PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31907205-11	2020	In conclusion, the protective effect of HDL to counter ER stress and beta-cell death involves the transport, generation and mobilization of oxysterols for activation of the hedgehog signalling receptor Smo.	arthrofactin	140-150	smoothened, frizzled class receptor	Homo sapiens	202-205
32023146-1	2020	OSBPL1 encodes the full-length oxysterol binding protein-related protein ORP1L, which transports LDL-derived cholesterol at membrane contacts between the late endosomes/lysosomes (LEL) and endoplasmic reticulum (ER).	arthrofactin	31-40	oxysterol binding protein 2	Homo sapiens	0-6
31980500-1	2020	Liver X receptors (LXRs), LXRalpha and LXRbeta, are nuclear receptors that regulate the metabolism of cholesterol and bile acids and are activated by oxysterols.	arthrofactin	150-160	nuclear receptor subfamily 1, group H, member 3	Mus musculus	26-34
31980500-1	2020	Liver X receptors (LXRs), LXRalpha and LXRbeta, are nuclear receptors that regulate the metabolism of cholesterol and bile acids and are activated by oxysterols.	arthrofactin	150-160	nuclear receptor subfamily 1, group H, member 2	Mus musculus	39-46
31928972-4	2020	pH biosensing by TGN PI4P in response to nutrient availability governs protein sorting at the TGN, likely by regulating sterol transfer to the TGN by Osh1, a member of the conserved oxysterol-binding protein (OSBP) family of lipid transfer proteins.	arthrofactin	182-191	oxysterol-binding protein related protein SWH1	Saccharomyces cerevisiae S288C	150-154
31882567-1	2020	Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as Diabetic Peripheral Neuropathy (DPN).This work highlights the role of the oxysterol/LXR signaling pathway and the crosstalk with the reactive oxygen species (ROS) producing enzyme, NADPH oxidase-4 (Nox4) in the pathogenesis of DPN.Herein, we assess behavioral, molecular and physio-pathological changes in cultured Schwann cells as well as in the sciatic nerve of a type 1 diabetic (T1DM) murine model, and skin biopsies from type 2 diabetic (T2DM) patients.T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by a defective peripheral myelin genes expression in MPZ and PMP22.	arthrofactin	187-196	nuclear receptor subfamily 1, group H, member 3	Mus musculus	197-200
31882567-1	2020	Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as Diabetic Peripheral Neuropathy (DPN).This work highlights the role of the oxysterol/LXR signaling pathway and the crosstalk with the reactive oxygen species (ROS) producing enzyme, NADPH oxidase-4 (Nox4) in the pathogenesis of DPN.Herein, we assess behavioral, molecular and physio-pathological changes in cultured Schwann cells as well as in the sciatic nerve of a type 1 diabetic (T1DM) murine model, and skin biopsies from type 2 diabetic (T2DM) patients.T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by a defective peripheral myelin genes expression in MPZ and PMP22.	arthrofactin	187-196	NADPH oxidase 4	Mus musculus	294-309
31882567-1	2020	Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as Diabetic Peripheral Neuropathy (DPN).This work highlights the role of the oxysterol/LXR signaling pathway and the crosstalk with the reactive oxygen species (ROS) producing enzyme, NADPH oxidase-4 (Nox4) in the pathogenesis of DPN.Herein, we assess behavioral, molecular and physio-pathological changes in cultured Schwann cells as well as in the sciatic nerve of a type 1 diabetic (T1DM) murine model, and skin biopsies from type 2 diabetic (T2DM) patients.T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by a defective peripheral myelin genes expression in MPZ and PMP22.	arthrofactin	187-196	NADPH oxidase 4	Mus musculus	311-315
31882567-1	2020	Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as Diabetic Peripheral Neuropathy (DPN).This work highlights the role of the oxysterol/LXR signaling pathway and the crosstalk with the reactive oxygen species (ROS) producing enzyme, NADPH oxidase-4 (Nox4) in the pathogenesis of DPN.Herein, we assess behavioral, molecular and physio-pathological changes in cultured Schwann cells as well as in the sciatic nerve of a type 1 diabetic (T1DM) murine model, and skin biopsies from type 2 diabetic (T2DM) patients.T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by a defective peripheral myelin genes expression in MPZ and PMP22.	arthrofactin	187-196	myelin protein zero	Homo sapiens	714-717
31882567-1	2020	Diabetes triggers peripheral nerve alterations at a structural and functional level, collectively referred to as Diabetic Peripheral Neuropathy (DPN).This work highlights the role of the oxysterol/LXR signaling pathway and the crosstalk with the reactive oxygen species (ROS) producing enzyme, NADPH oxidase-4 (Nox4) in the pathogenesis of DPN.Herein, we assess behavioral, molecular and physio-pathological changes in cultured Schwann cells as well as in the sciatic nerve of a type 1 diabetic (T1DM) murine model, and skin biopsies from type 2 diabetic (T2DM) patients.T1DM animals exhibit neurophysiological defects and sensorimotor abnormalities paralleled by a defective peripheral myelin genes expression in MPZ and PMP22.	arthrofactin	187-196	peripheral myelin protein 22	Homo sapiens	722-727
31852219-10	2020	CONCLUSIONS: Our data demonstrate silencing miR-144 has sex-specific effects and that treatment with antisense oligonucleotides to target miR-144 might result in enhancements in reverse cholesterol transport and oxysterol metabolism in patients with cardiovascular disease.	arthrofactin	212-221	microRNA 144	Homo sapiens	138-145
31852219-8	2020	As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice.	arthrofactin	42-51	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	72-78
31652618-0	2019	Inhibition of Non-Small Cell Lung Cancer Cells by Oxy210, an Oxysterol-Derivative that Antagonizes TGFbeta and Hedgehog Signaling.	arthrofactin	61-70	transforming growth factor, beta 1	Mus musculus	99-106
31852219-8	2020	As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice.	arthrofactin	42-51	cytochrome P450, family 7, subfamily b, polypeptide 1	Mus musculus	80-106
31852219-8	2020	As a molecular mechanism, we identify the oxysterol metabolizing enzyme CYP7B1 (cytochrome P450 enzyme 7B1) as a miR-144 regulated gene in male, but not female mice.	arthrofactin	42-51	microRNA 144	Mus musculus	113-120
31648575-1	2019	Oxysterol-binding protein-related protein (ORP) 4L acts as a scaffold protein assembling CD3-epsilon, G-alphaq/11, and PLC-beta3 into a complex at the plasma membrane that mediates inositol (1,4,5)-trisphosphate (IP3)-induced endoplasmic reticulum (ER) Ca2+ release and oxidative phosphorylation in T-cell acute lymphoblastic leukemia cells.	arthrofactin	0-9	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	89-100
31648575-1	2019	Oxysterol-binding protein-related protein (ORP) 4L acts as a scaffold protein assembling CD3-epsilon, G-alphaq/11, and PLC-beta3 into a complex at the plasma membrane that mediates inositol (1,4,5)-trisphosphate (IP3)-induced endoplasmic reticulum (ER) Ca2+ release and oxidative phosphorylation in T-cell acute lymphoblastic leukemia cells.	arthrofactin	0-9	phospholipase C beta 3	Homo sapiens	119-128
31757214-3	2019	Oxysterols provided from food or cholesterol oxidation in the gastric epithelium may be further sulfated by hydroxysteroid sulfotransferase 2B1 (SULT2B1), which is highly abundant in the gastric epithelium.	arthrofactin	0-10	sulfotransferase family, cytosolic, 2B, member 1	Mus musculus	145-152
31828178-2	2019	Lack of CYP7B1 leads to an accumulation of its oxysterol substrates, in particular 25-hydroxycholesterol and 27-hydroxycholesterol that are able to cross the blood-brain barrier and have neurotoxic properties.	arthrofactin	47-56	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	8-14
31828178-5	2019	A single-dose injection of either mouse or human CYP7B1 mRNA led to a pronounced degradation of oxysterols in liver and serum within 2 days of treatment.	arthrofactin	96-106	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	49-55
31828178-6	2019	Pharmacokinetics indicate a single injection of human CYP7B1 mRNA to be effective in reducing oxysterols for at least 5 days.	arthrofactin	94-104	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	54-60
31756018-2	2020	We reported that large-conductance Ca2+ - and voltage-activated K+ (slo1 BK) channels are suppressed by this oxysterol, which is presumably intercalated into cell membrane to access the outer surface of the channel.	arthrofactin	109-118	carbonic anhydrase 2	Homo sapiens	35-75
31652618-5	2019	In the current study, we report on the biological and pharmacological evaluation of Oxy210, an oxysterol-based dual inhibitor of TGFbeta and Hh signaling.	arthrofactin	95-104	transforming growth factor, beta 1	Mus musculus	129-136
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	arthrofactin	166-176	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	39-60
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	arthrofactin	166-176	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	62-69
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	arthrofactin	166-176	steroidogenic acute regulatory protein	Homo sapiens	114-120
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	arthrofactin	166-176	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	180-208
32015930-5	2019	Cholesterol transport to mitochondrial sterol 27-hydroxylase (CYP27A1) by steroidogenic acute regulatory protein (StarD1), and the subsequent 7alpha-hydroxylation of oxysterols by oxysterol 7alpha-hydroxylase (CYP7B1) are the key regulatory steps of the pathway.	arthrofactin	166-176	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	210-216
32015930-6	2019	Recent observations suggest CYP7B1 to be the ultimate controller of cellular oxysterol levels.	arthrofactin	77-86	cytochrome P450 family 7 subfamily B member 1	Homo sapiens	28-34
31805226-7	2019	XOR, activated after modification of the redox environment by either RBC-NOX or RBC-NOS activity, concurred to the overall oxidative/nitrosative stress by either oxysterols.	arthrofactin	162-172	xanthine dehydrogenase	Homo sapiens	0-3