PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32036474-4	2020	Western blot analysis with an antibody to gammaH2AX showed that DS00329 induced DNA damage and flow cytometry and western blotting confirmed that it triggered a G1 cell cycle arrest which correlated with decreased levels in Cyclin A, Cyclin B, Cyclin D1 and cyclin dependent kinase 2 and an increase in levels of the cyclin dependent kinase inhibitor p21.	ds00329	64-71	cyclin A2	Homo sapiens	224-232
32036474-4	2020	Western blot analysis with an antibody to gammaH2AX showed that DS00329 induced DNA damage and flow cytometry and western blotting confirmed that it triggered a G1 cell cycle arrest which correlated with decreased levels in Cyclin A, Cyclin B, Cyclin D1 and cyclin dependent kinase 2 and an increase in levels of the cyclin dependent kinase inhibitor p21.	ds00329	64-71	cyclin D1	Homo sapiens	244-253
32036474-4	2020	Western blot analysis with an antibody to gammaH2AX showed that DS00329 induced DNA damage and flow cytometry and western blotting confirmed that it triggered a G1 cell cycle arrest which correlated with decreased levels in Cyclin A, Cyclin B, Cyclin D1 and cyclin dependent kinase 2 and an increase in levels of the cyclin dependent kinase inhibitor p21.	ds00329	64-71	cyclin dependent kinase 2	Homo sapiens	258-283
32036474-4	2020	Western blot analysis with an antibody to gammaH2AX showed that DS00329 induced DNA damage and flow cytometry and western blotting confirmed that it triggered a G1 cell cycle arrest which correlated with decreased levels in Cyclin A, Cyclin B, Cyclin D1 and cyclin dependent kinase 2 and an increase in levels of the cyclin dependent kinase inhibitor p21.	ds00329	64-71	cyclin dependent kinase inhibitor 1A	Homo sapiens	351-354
32036474-5	2020	DS00329 treated glioblastoma cells exhibited morphological and molecular markers typical of apoptotic cells such as membrane blebbing and cell shrinkage and an increase in levels of cleaved PARP.	ds00329	0-7	collagen type XI alpha 2 chain	Homo sapiens	190-194
32036474-6	2020	Flow cytometry with annexin V-FITC/propidium iodide staining confirmed that DS00329 induced apoptotic cell death in glioblastoma cells.	ds00329	76-83	annexin A5	Homo sapiens	20-29
32036474-8	2020	Furthermore, DS00329 treatment of glioblastoma cells inhibited the phosphatidylinositol 3"-kinase/Akt cell survival pathway.	ds00329	13-20	AKT serine/threonine kinase 1	Homo sapiens	98-101