PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34955842-8	2021	Finally, it was proved that Trichomicin inhibited the Stat3 and NF-kappaB pathways and reduced the phosphorylation of Stat3 and p65 after LPS stimulation, thereby inhibiting the response of macrophages to pro-inflammatory stimuli.	trichomicin	28-39	signal transducer and activator of transcription 3	Homo sapiens	54-59
34955842-8	2021	Finally, it was proved that Trichomicin inhibited the Stat3 and NF-kappaB pathways and reduced the phosphorylation of Stat3 and p65 after LPS stimulation, thereby inhibiting the response of macrophages to pro-inflammatory stimuli.	trichomicin	28-39	nuclear factor kappa B subunit 1	Homo sapiens	64-73
34955842-8	2021	Finally, it was proved that Trichomicin inhibited the Stat3 and NF-kappaB pathways and reduced the phosphorylation of Stat3 and p65 after LPS stimulation, thereby inhibiting the response of macrophages to pro-inflammatory stimuli.	trichomicin	28-39	signal transducer and activator of transcription 3	Homo sapiens	118-123
34955842-8	2021	Finally, it was proved that Trichomicin inhibited the Stat3 and NF-kappaB pathways and reduced the phosphorylation of Stat3 and p65 after LPS stimulation, thereby inhibiting the response of macrophages to pro-inflammatory stimuli.	trichomicin	28-39	RELA proto-oncogene, NF-kB subunit	Homo sapiens	128-131
31707338-0	2020	A new compound Trichomicin exerts antitumor activity through STAT3 signaling inhibition.	trichomicin	15-26	signal transducer and activator of transcription 3	Homo sapiens	61-66
32317968-0	2020	Trichomicin Suppresses Colorectal Cancer via Comprehensive Regulation of IL-6 and TNFalpha in Tumor Cells, TAMs, and CAFs.	trichomicin	0-11	interleukin 6	Mus musculus	73-77
32317968-0	2020	Trichomicin Suppresses Colorectal Cancer via Comprehensive Regulation of IL-6 and TNFalpha in Tumor Cells, TAMs, and CAFs.	trichomicin	0-11	tumor necrosis factor	Mus musculus	82-90
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	94-105	interleukin 6	Mus musculus	25-29
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	94-105	tumor necrosis factor	Mus musculus	34-42
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	94-105	interleukin 6	Mus musculus	215-219
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	94-105	tumor necrosis factor	Mus musculus	224-232
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	174-185	interleukin 6	Mus musculus	25-29
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	174-185	tumor necrosis factor	Mus musculus	34-42
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	174-185	interleukin 6	Mus musculus	215-219
32317968-5	2020	The expression levels of IL-6 and TNFalpha were reduced in tumor tissues of mice treated with Trichomicin, which was consistent with results of in vitro experiments in which Trichomicin suppressed the expression of IL-6 and TNFalpha in tumor and stromal cells.	trichomicin	174-185	tumor necrosis factor	Mus musculus	224-232
32317968-6	2020	In addition, Trichomicin inhibited TNFalpha-induced activation of NF-kappaB and basal Stat3 signaling in vitro, which resulted in reduced expression of the immune checkpoint protein PD-L1 in tumor and stromal cells.	trichomicin	13-24	tumor necrosis factor	Mus musculus	35-43
32317968-6	2020	In addition, Trichomicin inhibited TNFalpha-induced activation of NF-kappaB and basal Stat3 signaling in vitro, which resulted in reduced expression of the immune checkpoint protein PD-L1 in tumor and stromal cells.	trichomicin	13-24	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
32317968-6	2020	In addition, Trichomicin inhibited TNFalpha-induced activation of NF-kappaB and basal Stat3 signaling in vitro, which resulted in reduced expression of the immune checkpoint protein PD-L1 in tumor and stromal cells.	trichomicin	13-24	signal transducer and activator of transcription 3	Mus musculus	86-91
32317968-6	2020	In addition, Trichomicin inhibited TNFalpha-induced activation of NF-kappaB and basal Stat3 signaling in vitro, which resulted in reduced expression of the immune checkpoint protein PD-L1 in tumor and stromal cells.	trichomicin	13-24	CD274 antigen	Mus musculus	182-187
32317968-7	2020	Conclusively, Trichomicin, a promising new drug candidate with antitumor activity, exerted antitumor effects against colon cancer through inhibition of the IL-6 and TNFalpha signaling pathways.	trichomicin	14-25	interleukin 6	Mus musculus	156-160
32317968-7	2020	Conclusively, Trichomicin, a promising new drug candidate with antitumor activity, exerted antitumor effects against colon cancer through inhibition of the IL-6 and TNFalpha signaling pathways.	trichomicin	14-25	tumor necrosis factor	Mus musculus	165-173
31707338-3	2020	Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment.	trichomicin	0-11	interleukin 6	Homo sapiens	71-75
31707338-3	2020	Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment.	trichomicin	0-11	signal transducer and activator of transcription 3	Homo sapiens	110-115
31707338-3	2020	Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment.	trichomicin	142-153	interleukin 6	Homo sapiens	71-75
31707338-3	2020	Trichomicin can significantly induce cancer cell apoptosis and reduced IL-6 expression and phosphorylation of STAT3 were found in response to Trichomicin treatment.	trichomicin	142-153	signal transducer and activator of transcription 3	Homo sapiens	110-115
31707338-4	2020	The blockade of IL-6 mediated JAK-STAT3 signaling pathway by Trichomicin was confirmed using reporter gene system.	trichomicin	61-72	interleukin 6	Homo sapiens	16-20
31707338-4	2020	The blockade of IL-6 mediated JAK-STAT3 signaling pathway by Trichomicin was confirmed using reporter gene system.	trichomicin	61-72	signal transducer and activator of transcription 3	Homo sapiens	34-39