PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33994056-0	2021	The piperine derivative HJ105 inhibits Abeta1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.	piperine	4-12	kelch like ECH associated protein 1	Homo sapiens	104-109
3564048-2	1987	Piperine and safrole interacted with different forms of cytochrome P-450 as indicated by their in vivo effect on drug metabolising enzymes and mixed function oxidases and electrophoretic patterns.	piperine	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	56-72
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	piperine	93-101	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	piperine	281-289	acetylcholinesterase (Cartwright blood group)	Homo sapiens	155-159
33979725-3	2021	The steady-state emission spectrum results showed that presence of static quenching mode for piperine, tacrine, curcumin, silibinin molecules with BSA and AChE complexes separately and this excitation-emission matrix analysis suggest that formation of ground-state complex between piperine, tacrine, curcumin, silibinin drugs and both BSA, AChE protein molecules.	piperine	281-289	acetylcholinesterase (Cartwright blood group)	Homo sapiens	340-344
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	interleukin 1 beta	Mus musculus	76-93
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	interleukin 1 alpha	Mus musculus	95-103
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	lectin, galactose binding, soluble 3	Mus musculus	109-119
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	lectin, galactose binding, soluble 3	Mus musculus	121-126
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	integrin alpha X	Mus musculus	177-182
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	interleukin 1 alpha	Mus musculus	184-192
33667521-9	2021	Piperine dramatically reduced the serum levels of lipopolysaccharide (LPS), interleukin-1beta (IL-1beta) and Galectin-3 (Gal-3), suppressed the expression of M1-like cytokines (CD11c, IL-1beta and Gal-3) in epididymal adipose tissues and islets.	piperine	0-8	lectin, galactose binding, soluble 3	Mus musculus	197-202
33667521-10	2021	Furthermore, piperine partially reversed the down-regulation of Pdx1, inhibited the up-regulation of ALDH1A3 in beta-cell, and these effects were closely related to the mTOR/S6/4E-BP1 signal pathway.	piperine	13-21	pancreatic and duodenal homeobox 1	Mus musculus	64-68
33667521-10	2021	Furthermore, piperine partially reversed the down-regulation of Pdx1, inhibited the up-regulation of ALDH1A3 in beta-cell, and these effects were closely related to the mTOR/S6/4E-BP1 signal pathway.	piperine	13-21	aldehyde dehydrogenase family 1, subfamily A3	Mus musculus	101-108
33667521-10	2021	Furthermore, piperine partially reversed the down-regulation of Pdx1, inhibited the up-regulation of ALDH1A3 in beta-cell, and these effects were closely related to the mTOR/S6/4E-BP1 signal pathway.	piperine	13-21	mechanistic target of rapamycin kinase	Mus musculus	169-173
34012879-0	2021	Protective effects of piperine on the retina of mice with streptozotocin-induced diabetes by suppressing HIF-1/VEGFA pathway and promoting PEDF expression.	piperine	22-30	vascular endothelial growth factor A	Mus musculus	111-116
34012879-0	2021	Protective effects of piperine on the retina of mice with streptozotocin-induced diabetes by suppressing HIF-1/VEGFA pathway and promoting PEDF expression.	piperine	22-30	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	139-143
34012879-7	2021	RESULTS: In hypoxia, 1-100 micromol/L piperine significantly decreased the expression of VEGFA mRNA and increased the expression of PEDF mRNA without affecting HIF-1alpha mRNA.	piperine	38-46	vascular endothelial growth factor A	Homo sapiens	89-94
34012879-7	2021	RESULTS: In hypoxia, 1-100 micromol/L piperine significantly decreased the expression of VEGFA mRNA and increased the expression of PEDF mRNA without affecting HIF-1alpha mRNA.	piperine	38-46	serpin family F member 1	Homo sapiens	132-136
34012879-7	2021	RESULTS: In hypoxia, 1-100 micromol/L piperine significantly decreased the expression of VEGFA mRNA and increased the expression of PEDF mRNA without affecting HIF-1alpha mRNA.	piperine	38-46	hypoxia inducible factor 1, alpha subunit	Mus musculus	160-170
34012879-8	2021	Meanwhile, 100 micromol/L piperine substantially decreased the protein level of VEGFA and increased the protein level of PEDF.	piperine	26-34	vascular endothelial growth factor A	Homo sapiens	80-85
34012879-8	2021	Meanwhile, 100 micromol/L piperine substantially decreased the protein level of VEGFA and increased the protein level of PEDF.	piperine	26-34	serpin family F member 1	Homo sapiens	121-125
34012879-9	2021	The HIF-1alpha protein level was also hampered by piperine.	piperine	50-58	hypoxia inducible factor 1, alpha subunit	Mus musculus	4-14
34012879-12	2021	Further, the protein levels of HIF-1alpha and VEGFA were significantly reduced by piperine.	piperine	82-90	hypoxia inducible factor 1, alpha subunit	Mus musculus	31-41
34012879-12	2021	Further, the protein levels of HIF-1alpha and VEGFA were significantly reduced by piperine.	piperine	82-90	vascular endothelial growth factor A	Mus musculus	46-51
34012879-13	2021	Moreover, the level of the antiangiogenic factor of PEDF dramatically increased by piperine.	piperine	83-91	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	52-56
34012879-14	2021	CONCLUSION: Piperine may exert protective effects on the retina of mice with diabetes via regulating the pro-antiangiogenic homeostasis composed of HIF-1/VEGFA and PEDF.	piperine	12-20	vascular endothelial growth factor A	Mus musculus	154-159
34012879-14	2021	CONCLUSION: Piperine may exert protective effects on the retina of mice with diabetes via regulating the pro-antiangiogenic homeostasis composed of HIF-1/VEGFA and PEDF.	piperine	12-20	serine (or cysteine) peptidase inhibitor, clade F, member 1	Mus musculus	164-168
2783973-0	1989	Involvement of calcitonin gene-related peptide in the positive chronotropic and inotropic effects of piperine and development of cross-tachyphylaxis between piperine and capsaicin in the isolated rat atria.	piperine	101-109	calcitonin-related polypeptide alpha	Rattus norvegicus	15-46
2783973-0	1989	Involvement of calcitonin gene-related peptide in the positive chronotropic and inotropic effects of piperine and development of cross-tachyphylaxis between piperine and capsaicin in the isolated rat atria.	piperine	157-165	calcitonin-related polypeptide alpha	Rattus norvegicus	15-46
2783973-7	1989	CGRP-like immunoreactivity was depleted considerably by treatment of the tissue with piperine or capsaicin.	piperine	85-93	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2783973-8	1989	When endogenous CGRP was depleted, although the positive chronotropic and inotropic effects of piperine and capsaicin were abolished, the effects of CGRP and isoproterenol were not affected.	piperine	95-103	calcitonin-related polypeptide alpha	Rattus norvegicus	16-20
2783973-9	1989	These results indicate that both piperine and capsaicin cause positive chronotropic and inotropic responses by releasing CGRP from nonadrenergic noncholinergic nerves, and that the development of cross-tachyphylaxis between piperine and capsaicin is due to the depletion of endogenous CGRP.	piperine	33-41	calcitonin-related polypeptide alpha	Rattus norvegicus	121-125
2783973-9	1989	These results indicate that both piperine and capsaicin cause positive chronotropic and inotropic responses by releasing CGRP from nonadrenergic noncholinergic nerves, and that the development of cross-tachyphylaxis between piperine and capsaicin is due to the depletion of endogenous CGRP.	piperine	33-41	calcitonin-related polypeptide alpha	Rattus norvegicus	285-289
2783973-9	1989	These results indicate that both piperine and capsaicin cause positive chronotropic and inotropic responses by releasing CGRP from nonadrenergic noncholinergic nerves, and that the development of cross-tachyphylaxis between piperine and capsaicin is due to the depletion of endogenous CGRP.	piperine	224-232	calcitonin-related polypeptide alpha	Rattus norvegicus	285-289
3263589-3	1988	After exposure to piperine in vitro, endogenous calcitonin gene-related peptide (CGRP) was profoundly depleted from intracardiac nerves.	piperine	18-26	calcitonin-related polypeptide alpha	Rattus norvegicus	48-79
3263589-3	1988	After exposure to piperine in vitro, endogenous calcitonin gene-related peptide (CGRP) was profoundly depleted from intracardiac nerves.	piperine	18-26	calcitonin-related polypeptide alpha	Rattus norvegicus	81-85
3263589-4	1988	These results suggest that piperine releases endogenous CGRP from intracardiac non-adrenergic non-cholinergic nerves and that released CGRP exerts positive chronotropic and inotropic effects.	piperine	27-35	calcitonin-related polypeptide alpha	Rattus norvegicus	56-60
3917507-5	1985	Inhibition by piperine of arylhydrocarbon hydroxylase (AHH) from 3-methylcholanthrene-treated rats was comparable to that observed with 7,8-benzoflavone.	piperine	14-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	26-53
3917507-5	1985	Inhibition by piperine of arylhydrocarbon hydroxylase (AHH) from 3-methylcholanthrene-treated rats was comparable to that observed with 7,8-benzoflavone.	piperine	14-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	55-58
3917507-6	1985	Piperine caused noncompetitive inhibition of hepatic microsomal AHH from the untreated and 3-methylcholanthrene-treated rats with a Ki of 30 microM which was close to the apparent Km of AHH observed in the controls.	piperine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	64-67
3917507-6	1985	Piperine caused noncompetitive inhibition of hepatic microsomal AHH from the untreated and 3-methylcholanthrene-treated rats with a Ki of 30 microM which was close to the apparent Km of AHH observed in the controls.	piperine	0-8	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	186-189
3917507-9	1985	Oral administration of piperine in rats strongly inhibited the hepatic AHH and UDP-glucuronyltransferase activities.	piperine	23-31	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	71-74
33743225-3	2021	Since piperine is known as an effective molecule against metastasis, we thought to investigate the effect of piperine against CD44+/CD133+ CSCs.	piperine	109-117	CD44 molecule (Indian blood group)	Homo sapiens	126-130
33743225-3	2021	Since piperine is known as an effective molecule against metastasis, we thought to investigate the effect of piperine against CD44+/CD133+ CSCs.	piperine	109-117	prominin 1	Homo sapiens	132-137
33743225-8	2021	Piperine was found able to repress the epithelial marker (E-cadherin) but was unable to restore the level of Vimentin (mesenchymal marker) and SNAIL (EMT-inducing transcription factor).	piperine	0-8	cadherin 1	Homo sapiens	58-68
33921897-8	2021	We observed an increase in PTPRK expression correlated with decreased pTYR level after piperine treatment and downregulation of P-gp and BCRP expression.	piperine	87-95	protein tyrosine phosphatase receptor type K	Homo sapiens	27-32
33994056-0	2021	The piperine derivative HJ105 inhibits Abeta1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.	piperine	4-12	NFE2 like bZIP transcription factor 2	Homo sapiens	110-114
33994056-0	2021	The piperine derivative HJ105 inhibits Abeta1-42-induced neuroinflammation and oxidative damage via the Keap1-Nrf2-TXNIP axis.	piperine	4-12	thioredoxin interacting protein	Homo sapiens	115-120
33919582-1	2021	Piperine is an alkaloid that has extensive pharmacological activity and impacts other active substances bioavailability due to inhibition of CYP450 enzymes, stimulation of amino acid transporters and P-glycoprotein inhibition.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	200-214
33833371-1	2021	Its pungent perception is due to the interaction of its major compound, piperine (1-piperoyl-piperidine) with the human TRPV-1 or vanilloid receptor.	piperine	72-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-126
33919582-3	2021	The combination of piperine with 2-hydroxypropyl-beta-cyclodextrin (HP-beta-CD) causes a significant increase in its solubility and, consequently, an increase in permeability through gastrointestinal tract membranes and the blood-brain barrier.	piperine	19-27	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	71-78
33919582-4	2021	X-ray powder diffraction (XRPD), differential scanning calorimetry (DSC), Fourier-transform infrared spectroscopy (FT-IR), nuclear magnetic resonance (NMR) were used to characterize interactions between piperine and HP-beta-CD.	piperine	203-211	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	219-226
33919582-6	2021	Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase).	piperine	64-72	acetylcholinesterase (Cartwright blood group)	Homo sapiens	355-375
33919582-6	2021	Importantly, with an increase in solubility and permeability of piperine as a result of interaction with CD, it was proven to maintain its biological activity concerning the antioxidant potential (2,2-diphenyl-1-picryl-hydrazyl-hydrate assay), inhibition of enzymes essential for the inflammatory process and for neurodegenerative changes (hyaluronidase, acetylcholinesterase, butyrylcholinesterase).	piperine	64-72	butyrylcholinesterase	Homo sapiens	377-398
33833371-1	2021	Its pungent perception is due to the interaction of its major compound, piperine (1-piperoyl-piperidine) with the human TRPV-1 or vanilloid receptor.	piperine	82-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-126
33492139-0	2021	Natural Piperine Improves Lipid Metabolic Profile of High-Fat Diet-Fed Mice by Upregulating SR-B1 and ABCG8 Transporters.	piperine	8-16	scavenger receptor class B, member 1	Mus musculus	92-97
33578085-8	2021	The colloidal mercuric formulation upregulated the expression of TGF-beta, IL-6 and TNF-alpha, due to the presence of arsenic and other organic compounds such as piperine.	piperine	162-170	transforming growth factor alpha	Homo sapiens	65-73
33578085-8	2021	The colloidal mercuric formulation upregulated the expression of TGF-beta, IL-6 and TNF-alpha, due to the presence of arsenic and other organic compounds such as piperine.	piperine	162-170	interleukin 6	Homo sapiens	75-79
33578085-8	2021	The colloidal mercuric formulation upregulated the expression of TGF-beta, IL-6 and TNF-alpha, due to the presence of arsenic and other organic compounds such as piperine.	piperine	162-170	tumor necrosis factor	Homo sapiens	84-93
33667839-0	2021	Piperine and Celecoxib synergistically inhibit colon cancer cell proliferation via modulating Wnt/beta-catenin signaling pathway.	piperine	0-8	catenin beta 1	Homo sapiens	98-110
33737876-11	2020	The gene expression profile in brain tissue shows significantly reduced BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes in the piperine and sitagliptin (PC) treated groups compared to Diabetic (STZ) control.	piperine	129-137	beta-secretase 1	Rattus norvegicus	72-77
33737876-11	2020	The gene expression profile in brain tissue shows significantly reduced BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes in the piperine and sitagliptin (PC) treated groups compared to Diabetic (STZ) control.	piperine	129-137	presenilin 1	Rattus norvegicus	79-84
33737876-11	2020	The gene expression profile in brain tissue shows significantly reduced BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes in the piperine and sitagliptin (PC) treated groups compared to Diabetic (STZ) control.	piperine	129-137	apoptotic peptidase activating factor 1	Rattus norvegicus	86-91
33737876-11	2020	The gene expression profile in brain tissue shows significantly reduced BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes in the piperine and sitagliptin (PC) treated groups compared to Diabetic (STZ) control.	piperine	129-137	caspase 3	Rattus norvegicus	93-101
33737876-11	2020	The gene expression profile in brain tissue shows significantly reduced BACE1, PSEN1, APAF1, CASPASE3, and CATALASE genes in the piperine and sitagliptin (PC) treated groups compared to Diabetic (STZ) control.	piperine	129-137	catalase	Rattus norvegicus	107-115
31711686-0	2021	Corrigendum to "Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens".	piperine	26-34	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	95-102
33732347-0	2021	Piperine protects against myocardial ischemia/reperfusion injury by activating the PI3K/AKT signaling pathway.	piperine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	88-91
33732347-13	2021	Mechanistic studies concluded that the apoptosis-inhibitory contributions and cardio-favorable effects of PIP were caused partly by the activation of the PI3K/AKT signaling pathway, which was verified by LY294002 administration.	piperine	106-109	AKT serine/threonine kinase 1	Rattus norvegicus	159-162
33732347-14	2021	To conclude, PIP can reduce ERS-induced apoptosis by activating the PI3K/AKT signaling pathway during the process of H/R injury, which could be a potential therapeutic target for the treatment of myocardial ischemia/reperfusion injury.	piperine	13-16	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
33492139-0	2021	Natural Piperine Improves Lipid Metabolic Profile of High-Fat Diet-Fed Mice by Upregulating SR-B1 and ABCG8 Transporters.	piperine	8-16	ATP binding cassette subfamily G member 8	Mus musculus	102-107
33492139-5	2021	Mechanistically, piperine treatment caused a significant upregulation of hepatic scavenger receptor B1 (SR-B1) in the liver and transporter protein of ATP binding cassette SGM8 (ABCG8) in the small intestine.	piperine	17-25	scavenger receptor class B, member 1	Mus musculus	81-102
33492139-5	2021	Mechanistically, piperine treatment caused a significant upregulation of hepatic scavenger receptor B1 (SR-B1) in the liver and transporter protein of ATP binding cassette SGM8 (ABCG8) in the small intestine.	piperine	17-25	scavenger receptor class B, member 1	Mus musculus	104-109
33492139-5	2021	Mechanistically, piperine treatment caused a significant upregulation of hepatic scavenger receptor B1 (SR-B1) in the liver and transporter protein of ATP binding cassette SGM8 (ABCG8) in the small intestine.	piperine	17-25	ATP binding cassette subfamily G member 8	Mus musculus	178-183
33492139-6	2021	Taken together, our findings demonstrate the role of natural piperine in improving lipid metabolic profile that is involved in the reverse cholesterol transport (RCT)-mediated mechanism through upregulation of SR-B1 in the liver and ABCG8 in the small intestine.	piperine	61-69	scavenger receptor class B, member 1	Mus musculus	210-215
33492139-6	2021	Taken together, our findings demonstrate the role of natural piperine in improving lipid metabolic profile that is involved in the reverse cholesterol transport (RCT)-mediated mechanism through upregulation of SR-B1 in the liver and ABCG8 in the small intestine.	piperine	61-69	ATP binding cassette subfamily G member 8	Mus musculus	233-238
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	piperine	33-41	CREB regulated transcription coactivator 1	Mus musculus	78-84
33884168-8	2021	The anti-proliferative effect of both BP-M and PIP was also observed by trypan blue staining and was further confirmed by the downregulated expression of proliferating cell nuclear antigen (PCNA).	piperine	47-50	proliferating cell nuclear antigen	Homo sapiens	154-188
33884168-8	2021	The anti-proliferative effect of both BP-M and PIP was also observed by trypan blue staining and was further confirmed by the downregulated expression of proliferating cell nuclear antigen (PCNA).	piperine	47-50	proliferating cell nuclear antigen	Homo sapiens	190-194
33884168-9	2021	The molecular docking studies showed the binding of PIP with PCNA and Bcl-2 and supported the in vitro findings.	piperine	52-55	proliferating cell nuclear antigen	Homo sapiens	61-65
33884168-9	2021	The molecular docking studies showed the binding of PIP with PCNA and Bcl-2 and supported the in vitro findings.	piperine	52-55	BCL2 apoptosis regulator	Homo sapiens	70-75
33884168-10	2021	The docking studies also proposed the binding of PIP to ADP binding pocket of Apaf-1 protein.	piperine	49-52	apoptotic peptidase activating factor 1	Homo sapiens	78-84
33578817-3	2021	The aim of this study was to investigate the effect of piperine, a phytochemical from black pepper, on CS induction in CML MDR cells, and the mechanisms involved.	piperine	55-63	citrate synthase	Homo sapiens	103-105
33578817-4	2021	The results indicate that piperine induced CS, being more cytotoxic to K562-derived MDR cells (Lucena-1 and FEPS) than to K562, the parental CML cell.	piperine	26-34	citrate synthase	Homo sapiens	43-45
33578817-7	2021	To investigate a P-gp independent mechanism, we analyzed the possibility that poly (ADP-ribose) polymerase-1 (PARP-1) could be involved in piperine cytotoxic effects.	piperine	139-147	poly(ADP-ribose) polymerase 1	Homo sapiens	78-108
33578817-7	2021	To investigate a P-gp independent mechanism, we analyzed the possibility that poly (ADP-ribose) polymerase-1 (PARP-1) could be involved in piperine cytotoxic effects.	piperine	139-147	poly(ADP-ribose) polymerase 1	Homo sapiens	110-116
33578817-9	2021	In the present study, piperine was able to decrease the 24 kDa fragment of PARP-1 in MDR FEPS cells.	piperine	22-30	poly(ADP-ribose) polymerase 1	Homo sapiens	75-81
33578817-10	2021	We conclude that piperine targets selectively MDR cells, inducing CS, through a mechanism that might be dependent or not on P-gp.	piperine	17-25	citrate synthase	Homo sapiens	66-68
33578817-10	2021	We conclude that piperine targets selectively MDR cells, inducing CS, through a mechanism that might be dependent or not on P-gp.	piperine	17-25	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	piperine	33-41	CREB regulated transcription coactivator 1	Mus musculus	269-275
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	piperine	33-41	CREB regulated transcription coactivator 2	Mus musculus	285-291
33220404-4	2021	Curcumin or its combination with piperine, but not piperine alone, suppressed mTORC1 kinase activity, curtailed lipopolysaccharide-mediated inflammatory response of THP-1 macrophages, and repressed macrophage activation by inhibiting signaling pathways involved in M1 (mTORC1) and M2 (mTORC2, CREB) polarization.	piperine	33-41	cAMP responsive element binding protein 1	Homo sapiens	293-297
33501847-6	2021	Components of pepper, piperine and beta-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds.	piperine	22-30	apoptotic peptidase activating factor 1	Homo sapiens	115-153
33501847-6	2021	Components of pepper, piperine and beta-caryophyllene were found to interact with superoxide dismutase [Cu-Zn] and apoptotic protease-activating factor-1-caspase-9 through different amino acids via H-bonds.	piperine	22-30	caspase 9	Homo sapiens	154-163
33514009-1	2021	In this study, the amino acid arginine (ARG) and P-glycoprotein (P-gp) inhibitors verapamil hydrochloride (VER), piperine (PIP) and quercetin (QRT) were used as co-formers for co-amorphous mixtures of a Biopharmaceutics classification system (BCS) class IV drug, furosemide (FUR).	piperine	123-126	ATP binding cassette subfamily B member 1	Homo sapiens	65-69
33544523-9	2021	The modulatory and antioxidant berberine and piperine properties on these enzymes (AChE, BChE and MAO) could be possible underlying mechanisms in employing these compounds as a complementary therapy in neurodegenerative diseases (NDDs) management.	piperine	45-53	acetylcholinesterase (Cartwright blood group)	Homo sapiens	83-87
33544523-9	2021	The modulatory and antioxidant berberine and piperine properties on these enzymes (AChE, BChE and MAO) could be possible underlying mechanisms in employing these compounds as a complementary therapy in neurodegenerative diseases (NDDs) management.	piperine	45-53	butyrylcholinesterase	Homo sapiens	89-93
33353024-0	2020	Detailed Characterization of the Cooperative Binding of Piperine with Heat Shock Protein 70 by Molecular Biophysical Approaches.	piperine	56-64	heat shock protein family A (Hsp70) member 4	Homo sapiens	70-91
32633857-0	2021	Overcoming vincristine resistance in cancer: computational design and discovery of piperine inspired P-glycoprotein inhibitors.	piperine	83-91	ATP binding cassette subfamily B member 1	Homo sapiens	101-115
32633857-5	2021	In this study, two piperine analogs (3 and 4) having lower cross-reactivity with CYP3A4 drug metabolizing enzyme are identified as P-glycoprotein (P-gp) inhibitors through computational design, followed by synthesis and testing in MDR cancer cell lines overexpressing P-gp (KB ChR 8-5, SW480-VCR and HCT-15).	piperine	19-27	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
32633857-5	2021	In this study, two piperine analogs (3 and 4) having lower cross-reactivity with CYP3A4 drug metabolizing enzyme are identified as P-glycoprotein (P-gp) inhibitors through computational design, followed by synthesis and testing in MDR cancer cell lines overexpressing P-gp (KB ChR 8-5, SW480-VCR and HCT-15).	piperine	19-27	ATP binding cassette subfamily B member 1	Homo sapiens	131-145
32633857-5	2021	In this study, two piperine analogs (3 and 4) having lower cross-reactivity with CYP3A4 drug metabolizing enzyme are identified as P-glycoprotein (P-gp) inhibitors through computational design, followed by synthesis and testing in MDR cancer cell lines overexpressing P-gp (KB ChR 8-5, SW480-VCR and HCT-15).	piperine	19-27	ATP binding cassette subfamily B member 1	Homo sapiens	147-151
32633857-5	2021	In this study, two piperine analogs (3 and 4) having lower cross-reactivity with CYP3A4 drug metabolizing enzyme are identified as P-glycoprotein (P-gp) inhibitors through computational design, followed by synthesis and testing in MDR cancer cell lines overexpressing P-gp (KB ChR 8-5, SW480-VCR and HCT-15).	piperine	19-27	ATP binding cassette subfamily B member 1	Homo sapiens	268-272
33459225-8	2021	Regarding terpenoids and alkaloids, nimbin, withaferin A, andrographolide, zingiberene and, berberine, piperine and thebaine, respectively, showed binding affinity with molecular ACE-2 target in silico.	piperine	103-111	angiotensin converting enzyme 2	Homo sapiens	179-184
33219747-0	2021	Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR-383/RP105/AKT signalling pathway.	piperine	0-8	microRNA 383	Rattus norvegicus	98-105
33219747-0	2021	Piperine protects against pyroptosis in myocardial ischaemia/reperfusion injury by regulating the miR-383/RP105/AKT signalling pathway.	piperine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
33219747-3	2021	This study focuses on whether PIP protects MIRI from pyroptosis via miR-383-dependent pathway.	piperine	30-33	microRNA 383	Rattus norvegicus	68-75
33219747-12	2021	In mechanistic studies, MIRI-caused elevation of miR-383 and decrease of RP105/PI3K/AKT pathway were reverted by PIP treatment.	piperine	113-116	microRNA 383	Rattus norvegicus	49-56
33219747-12	2021	In mechanistic studies, MIRI-caused elevation of miR-383 and decrease of RP105/PI3K/AKT pathway were reverted by PIP treatment.	piperine	113-116	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
33219747-16	2021	Additionally, our present study further indicated the miR-383/RP105/AKT-dependent approach resulting from PIP administration against pyroptosis in MIRI.	piperine	106-109	microRNA 383	Rattus norvegicus	54-61
33219747-16	2021	Additionally, our present study further indicated the miR-383/RP105/AKT-dependent approach resulting from PIP administration against pyroptosis in MIRI.	piperine	106-109	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
33219747-17	2021	Therefore, PIP treatment attenuates MIRI and pyroptosis by regulating miR-383/RP105/AKT pathway, and it may provide a therapeutic manner for the treatment of MIRI.	piperine	11-14	microRNA 383	Rattus norvegicus	70-77
33219747-17	2021	Therefore, PIP treatment attenuates MIRI and pyroptosis by regulating miR-383/RP105/AKT pathway, and it may provide a therapeutic manner for the treatment of MIRI.	piperine	11-14	AKT serine/threonine kinase 1	Rattus norvegicus	84-87
33382670-8	2020	Piperine upregulated the protein expression of Bax, Bad, Cyto C, cleaved PARP, and cleaved caspase-3, but downregulated the protein expression of Bcl-2, Bcl-xl, pPI3k, and pAkt.	piperine	0-8	BCL2 apoptosis regulator	Homo sapiens	146-151
33382670-8	2020	Piperine upregulated the protein expression of Bax, Bad, Cyto C, cleaved PARP, and cleaved caspase-3, but downregulated the protein expression of Bcl-2, Bcl-xl, pPI3k, and pAkt.	piperine	0-8	BCL2 like 1	Homo sapiens	153-159
33382670-11	2020	Piperine enhanced cleaved caspase-3 expression but decreased Ki-67 expression in a dose-dependent manner.	piperine	0-8	caspase 3	Homo sapiens	26-35
33382670-13	2020	CONCLUSIONS Our findings suggest that piperine inhibits proliferation and induces apoptosis of human gastric cancer cells through inhibition of the PI3K/Akt signaling pathway.	piperine	38-46	AKT serine/threonine kinase 1	Homo sapiens	153-156
33279562-5	2021	Also, ME(INS)-PiP-Alb rendered higher protection to INS in presence of pepsin and trypsin than ME(INS)-PiP.	piperine	14-17	albumin	Homo sapiens	18-21
33279562-7	2021	Whereas, in permeability studies ME(INS)-PiP-Alb showed ~4 and ~1.5-fold enhanced permeation than free INS and ME(INS) without PiP groups respectively.	piperine	41-44	albumin	Homo sapiens	45-48
33370686-7	2021	Luna C18 column was used under isocratic conditions to separate curcumin, piperine, and emodin with baseline resolution, and with good separation from other sample components, in as little as 4 min.	piperine	74-82	Bardet-Biedl syndrome 9	Homo sapiens	5-8
33382670-0	2020	Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway.	piperine	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	107-136
33382670-0	2020	Piperine Inhibits Cell Proliferation and Induces Apoptosis of Human Gastric Cancer Cells by Downregulating Phosphatidylinositol 3-Kinase (PI3K)/Akt Pathway.	piperine	0-8	AKT serine/threonine kinase 1	Homo sapiens	144-147
33382670-5	2020	To further investigate the anti-tumor mechanism of piperine in SNU-16 cells, we used a small-molecule Akt activator SC79 in this study.	piperine	51-59	AKT serine/threonine kinase 1	Homo sapiens	102-105
33382670-8	2020	Piperine upregulated the protein expression of Bax, Bad, Cyto C, cleaved PARP, and cleaved caspase-3, but downregulated the protein expression of Bcl-2, Bcl-xl, pPI3k, and pAkt.	piperine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	47-50
33382670-8	2020	Piperine upregulated the protein expression of Bax, Bad, Cyto C, cleaved PARP, and cleaved caspase-3, but downregulated the protein expression of Bcl-2, Bcl-xl, pPI3k, and pAkt.	piperine	0-8	collagen type XI alpha 2 chain	Homo sapiens	73-77
33382670-8	2020	Piperine upregulated the protein expression of Bax, Bad, Cyto C, cleaved PARP, and cleaved caspase-3, but downregulated the protein expression of Bcl-2, Bcl-xl, pPI3k, and pAkt.	piperine	0-8	caspase 3	Homo sapiens	91-100
33353024-1	2020	In this work, for the first time, details of the complex formed by heat shock protein 70 (HSP70) independent nucleotide binding domain (NBD) and piperine were characterized through experimental and computational molecular biophysical methods.	piperine	145-153	heat shock protein family A (Hsp70) member 4	Homo sapiens	67-88
33353024-1	2020	In this work, for the first time, details of the complex formed by heat shock protein 70 (HSP70) independent nucleotide binding domain (NBD) and piperine were characterized through experimental and computational molecular biophysical methods.	piperine	145-153	heat shock protein family A (Hsp70) member 4	Homo sapiens	90-95
33091445-8	2020	Pretreatment with piperine suppressed the activation of phosphorylated p38, JNK, and AP-1 as well as the levels of COX-2/PGE2 and iNOS synthesis, while UV-B-irradiated cells triggered the induction of these signaling molecules.	piperine	18-26	mitogen-activated protein kinase 14	Homo sapiens	71-74
33091445-8	2020	Pretreatment with piperine suppressed the activation of phosphorylated p38, JNK, and AP-1 as well as the levels of COX-2/PGE2 and iNOS synthesis, while UV-B-irradiated cells triggered the induction of these signaling molecules.	piperine	18-26	mitogen-activated protein kinase 8	Homo sapiens	76-79
33091445-8	2020	Pretreatment with piperine suppressed the activation of phosphorylated p38, JNK, and AP-1 as well as the levels of COX-2/PGE2 and iNOS synthesis, while UV-B-irradiated cells triggered the induction of these signaling molecules.	piperine	18-26	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	85-89
33091445-8	2020	Pretreatment with piperine suppressed the activation of phosphorylated p38, JNK, and AP-1 as well as the levels of COX-2/PGE2 and iNOS synthesis, while UV-B-irradiated cells triggered the induction of these signaling molecules.	piperine	18-26	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
33091445-8	2020	Pretreatment with piperine suppressed the activation of phosphorylated p38, JNK, and AP-1 as well as the levels of COX-2/PGE2 and iNOS synthesis, while UV-B-irradiated cells triggered the induction of these signaling molecules.	piperine	18-26	inositol-3-phosphate synthase 1	Homo sapiens	130-134
32892714-7	2020	STZ-induced alteration in heart ANP, BNP, cTn-I, Bcl2, Bax/Bcl2, and caspase3 mRNA expression was significantly (p < 0.05) restored by piperine treatment.	piperine	135-143	natriuretic peptide B	Rattus norvegicus	37-40
32892714-7	2020	STZ-induced alteration in heart ANP, BNP, cTn-I, Bcl2, Bax/Bcl2, and caspase3 mRNA expression was significantly (p < 0.05) restored by piperine treatment.	piperine	135-143	troponin I3, cardiac type	Rattus norvegicus	42-47
32892714-7	2020	STZ-induced alteration in heart ANP, BNP, cTn-I, Bcl2, Bax/Bcl2, and caspase3 mRNA expression was significantly (p < 0.05) restored by piperine treatment.	piperine	135-143	BCL2, apoptosis regulator	Rattus norvegicus	49-53
32892714-7	2020	STZ-induced alteration in heart ANP, BNP, cTn-I, Bcl2, Bax/Bcl2, and caspase3 mRNA expression was significantly (p < 0.05) restored by piperine treatment.	piperine	135-143	BCL2 associated X, apoptosis regulator	Rattus norvegicus	55-58
32892714-7	2020	STZ-induced alteration in heart ANP, BNP, cTn-I, Bcl2, Bax/Bcl2, and caspase3 mRNA expression was significantly (p < 0.05) restored by piperine treatment.	piperine	135-143	BCL2, apoptosis regulator	Rattus norvegicus	59-63
32892714-7	2020	STZ-induced alteration in heart ANP, BNP, cTn-I, Bcl2, Bax/Bcl2, and caspase3 mRNA expression was significantly (p < 0.05) restored by piperine treatment.	piperine	135-143	caspase 3	Rattus norvegicus	69-77
32892714-9	2020	In conclusion, the present investigation suggests that piperine ameliorates STZ-induced diabetic cardiomyopathy via modulation of caspase-3, Bcl2, Bax/Bcl2 pathways.	piperine	55-63	caspase 3	Rattus norvegicus	130-139
32892714-9	2020	In conclusion, the present investigation suggests that piperine ameliorates STZ-induced diabetic cardiomyopathy via modulation of caspase-3, Bcl2, Bax/Bcl2 pathways.	piperine	55-63	BCL2, apoptosis regulator	Rattus norvegicus	141-145
32892714-9	2020	In conclusion, the present investigation suggests that piperine ameliorates STZ-induced diabetic cardiomyopathy via modulation of caspase-3, Bcl2, Bax/Bcl2 pathways.	piperine	55-63	BCL2 associated X, apoptosis regulator	Rattus norvegicus	147-150
32892714-9	2020	In conclusion, the present investigation suggests that piperine ameliorates STZ-induced diabetic cardiomyopathy via modulation of caspase-3, Bcl2, Bax/Bcl2 pathways.	piperine	55-63	BCL2, apoptosis regulator	Rattus norvegicus	151-155
32500474-0	2020	Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition.	piperine	0-8	signal transducer and activator of transcription 3	Homo sapiens	73-78
32892714-0	2020	Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways.	piperine	79-87	BCL2, apoptosis regulator	Rattus norvegicus	92-96
32892714-0	2020	Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways.	piperine	79-87	BCL2 associated X, apoptosis regulator	Rattus norvegicus	98-101
32892714-0	2020	Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways.	piperine	79-87	BCL2, apoptosis regulator	Rattus norvegicus	102-106
32892714-0	2020	Streptozotocin-induced diabetic cardiomyopathy in rats: ameliorative effect of PIPERINE via Bcl2, Bax/Bcl2, and caspase-3 pathways.	piperine	79-87	caspase 3	Rattus norvegicus	112-121
33363626-8	2020	The nanoparticles also enhanced in vitro cytotoxicity and downregulation of P-gp expression in MDA-MB 453 cells compared to the commercial inhibitor verapamil hydrochloride, thus promising a piece of exciting evidence for the development of BioPerine based nano-drug delivery system in combination with traditional therapies as a crucial approach to tackling multi-drug resistance in cancers.	piperine	241-250	ATP binding cassette subfamily B member 1	Homo sapiens	76-80
33089532-10	2020	Interestingly, the expression of ERbeta was increased in the cells treated with piperine.	piperine	80-88	estrogen receptor 1	Homo sapiens	33-39
33350241-14	2020	As compared with the 3 MA group, the number of activities, ChAT, TH, and p62 expression levels were significantly reduced in the low and medium dose piperine groups and rapamycin group(P<0.05); howe-ver, their first foot licking time was significantly prolonged, APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were increased significantly(P<0.05).	piperine	149-157	choline acetyltransferase	Mus musculus	59-63
33350241-14	2020	As compared with the 3 MA group, the number of activities, ChAT, TH, and p62 expression levels were significantly reduced in the low and medium dose piperine groups and rapamycin group(P<0.05); howe-ver, their first foot licking time was significantly prolonged, APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were increased significantly(P<0.05).	piperine	149-157	tyrosine hydroxylase	Mus musculus	65-67
33350241-14	2020	As compared with the 3 MA group, the number of activities, ChAT, TH, and p62 expression levels were significantly reduced in the low and medium dose piperine groups and rapamycin group(P<0.05); howe-ver, their first foot licking time was significantly prolonged, APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were increased significantly(P<0.05).	piperine	149-157	nucleoporin 62	Mus musculus	73-76
33350241-15	2020	As compared with the medopar group, the number of activities, ChAT, TH, and p62 expression levels were significantly reduced in low dose piperine group and rapamycin group(P<0.05), but their first foot licking time was significantly extended, and APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were significantly increased(P<0.05).	piperine	137-145	nucleoporin 62	Mus musculus	76-79
33178356-0	2020	Vicinal difluorination as a C=C surrogate: an analog of piperine with enhanced solubility, photostability, and acetylcholinesterase inhibitory activity.	piperine	56-64	acetylcholinesterase (Cartwright blood group)	Homo sapiens	111-131
33178356-4	2020	We show that this fluorinated analog of piperine has superior physicochemical properties, and it also has higher potency and selectivity towards one particular drug target, acetylcholinesterase.	piperine	40-48	acetylcholinesterase (Cartwright blood group)	Homo sapiens	173-193
33026807-0	2020	Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.	piperine	21-29	peroxiredoxin 5	Homo sapiens	43-47
33026807-0	2020	Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.	piperine	21-29	mitogen-activated protein kinase 14	Homo sapiens	103-106
33026807-0	2020	Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.	piperine	21-29	AKT serine/threonine kinase 1	Homo sapiens	111-114
33026807-0	2020	Piperlonguminine and Piperine Analogues as TrxR Inhibitors that Promote ROS and Autophagy and Regulate p38 and Akt/mTOR Signaling.	piperine	21-29	mechanistic target of rapamycin kinase	Homo sapiens	115-119
33028294-10	2020	Piperine markedly decreased the total and differential white blood cell (WBC) count, the serum levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines such as galectin-3 (Gal-3) and interleukin-1beta (IL-1beta).	piperine	0-8	lectin, galactose binding, soluble 3	Mus musculus	169-179
33028294-10	2020	Piperine markedly decreased the total and differential white blood cell (WBC) count, the serum levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines such as galectin-3 (Gal-3) and interleukin-1beta (IL-1beta).	piperine	0-8	lectin, galactose binding, soluble 3	Mus musculus	181-186
33028294-10	2020	Piperine markedly decreased the total and differential white blood cell (WBC) count, the serum levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines such as galectin-3 (Gal-3) and interleukin-1beta (IL-1beta).	piperine	0-8	interleukin 1 beta	Mus musculus	192-209
33028294-10	2020	Piperine markedly decreased the total and differential white blood cell (WBC) count, the serum levels of lipopolysaccharide (LPS) and pro-inflammatory cytokines such as galectin-3 (Gal-3) and interleukin-1beta (IL-1beta).	piperine	0-8	interleukin 1 alpha	Mus musculus	211-219
33028294-11	2020	Furthermore, piperine clearly down-regulated the mRNA levels of pro-inflammatory cytokines and the protein levels of M1-like polarization marker CD11c and Gal-3 in adipose tissues.	piperine	13-21	integrin alpha X	Mus musculus	145-150
33028294-11	2020	Furthermore, piperine clearly down-regulated the mRNA levels of pro-inflammatory cytokines and the protein levels of M1-like polarization marker CD11c and Gal-3 in adipose tissues.	piperine	13-21	lectin, galactose binding, soluble 3	Mus musculus	155-160
33364594-3	2021	Piperine is a small molecule that has been shown to destabilize the SRX in rabbit fast twitch fibers.	piperine	0-8	sulfiredoxin 1	Homo sapiens	68-71
33364594-7	2021	Addition of 100 muM piperine decreased the SRX population by 43 +- 7% in lean subjects and 36 +- 7% in obese subjects, with little change in lifetimes.	piperine	20-28	sulfiredoxin 1	Homo sapiens	43-46
33364594-9	2021	Conclusions: In human muscle the SRX and its responses to piperine are similar to those seen previously, with no significant differences between muscles from lean and obese subjects.	piperine	58-66	sulfiredoxin 1	Homo sapiens	33-36
33350241-12	2020	The results of this study showed that, as compared with the model group, the number of activities, the expression levels of ChAT, TH, and p62 were significantly increased in the 3 MA group, the various piperine dose groups, and the medopar group(P<0.05), and their first foot licking time was shortened; APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were significantly reduced(P<0.05).	piperine	202-210	choline acetyltransferase	Mus musculus	124-128
33350241-12	2020	The results of this study showed that, as compared with the model group, the number of activities, the expression levels of ChAT, TH, and p62 were significantly increased in the 3 MA group, the various piperine dose groups, and the medopar group(P<0.05), and their first foot licking time was shortened; APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were significantly reduced(P<0.05).	piperine	202-210	tyrosine hydroxylase	Mus musculus	130-132
33350241-12	2020	The results of this study showed that, as compared with the model group, the number of activities, the expression levels of ChAT, TH, and p62 were significantly increased in the 3 MA group, the various piperine dose groups, and the medopar group(P<0.05), and their first foot licking time was shortened; APP, p-tau, IL-6, TNF-alpha, alpha-syn, beclin-1, LC3 B and mmu-miR-99 a-5 p expression levels were significantly reduced(P<0.05).	piperine	202-210	nucleoporin 62	Mus musculus	138-141
32500474-0	2020	Piperine inhibits colorectal cancer migration and invasion by regulating STAT3/Snail-mediated epithelial-mesenchymal transition.	piperine	0-8	snail family transcriptional repressor 1	Homo sapiens	79-84
32500474-5	2020	Then, we found piperine reversed the biomarker expression of epithelial-to-mesenchymal transition (EMT), and suppressed the EMT regulator Snail.	piperine	15-23	snail family transcriptional repressor 1	Homo sapiens	138-143
32500474-6	2020	Furthermore, signal transducers and activators of transcription 3 (STAT3) was downregulated by piperine.	piperine	95-103	signal transducer and activator of transcription 3	Homo sapiens	13-65
32500474-6	2020	Furthermore, signal transducers and activators of transcription 3 (STAT3) was downregulated by piperine.	piperine	95-103	signal transducer and activator of transcription 3	Homo sapiens	67-72
32500474-8	2020	Collectively, piperine inhibits colorectal cancer migratory and invasive capacities through STAT3/Snail mediated EMT.	piperine	14-22	signal transducer and activator of transcription 3	Homo sapiens	92-97
32500474-8	2020	Collectively, piperine inhibits colorectal cancer migratory and invasive capacities through STAT3/Snail mediated EMT.	piperine	14-22	snail family transcriptional repressor 1	Homo sapiens	98-103
33090425-0	2020	Protective mechanisms of piperine against acetaminophen-induced hepatotoxicity may be mediated through TGFBRAP1.	piperine	25-33	transforming growth factor, beta receptor associated protein 1	Mus musculus	103-111
33090425-8	2020	Interestingly, piperine administration enhanced hepatic TGFBRAP1 expression compared to APAP alone.	piperine	15-23	transforming growth factor, beta receptor associated protein 1	Mus musculus	56-64
33090425-9	2020	CONCLUSIONS: The hepatoprotective effects of piperine against APAP are mediated via its antioxidant, anti-inflammatory, and anti-apoptotic effects, in addition to regulation of TGFBRAP1.	piperine	45-53	transforming growth factor, beta receptor associated protein 1	Mus musculus	177-185
33062432-0	2020	Explicating anti-amyloidogenic role of curcumin and piperine via amyloid beta (Abeta) explicit pathway: recovery and reversal paradigm effects.	piperine	52-60	amyloid beta precursor protein	Homo sapiens	65-77
32651226-3	2020	The TRPV1 agonists capsaicin and piperine have been shown to increase salivary flow when introduced into the oral cavity but the sialogogic properties of other TRP channel agonists have not been investigated.	piperine	33-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
32707496-5	2020	The results showed that the LPS-induced mammary histopathological changes and MPO activity were attenuated by piperine.	piperine	110-118	myeloperoxidase	Mus musculus	78-81
32707496-6	2020	LPS-induced inflammatory cytokines TNF-alpha andIL-1beta were also inhibited by piperine.	piperine	80-88	tumor necrosis factor	Mus musculus	35-56
32707496-7	2020	Furthermore, LPS-induced NF-kappaB activation was suppressed by the treatment with piperine.	piperine	83-91	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	25-34
32707496-8	2020	In addition, we found piperine dose-dependently increased the expression of PPARgamma.	piperine	22-30	peroxisome proliferator activated receptor gamma	Mus musculus	76-85
32707496-9	2020	All of these results suggested that piperine had protective effects against LPS-induced mastitis and that the mechanism may be mediated through the activation of PPARgamma.	piperine	36-44	peroxisome proliferator activated receptor gamma	Mus musculus	162-171
33062432-0	2020	Explicating anti-amyloidogenic role of curcumin and piperine via amyloid beta (Abeta) explicit pathway: recovery and reversal paradigm effects.	piperine	52-60	amyloid beta precursor protein	Homo sapiens	79-84
33062432-1	2020	Previously, we reported the synergistic effects of curcumin and piperine in cell cultures as potential anti-cholinesterase and anti-amyloidogenic agents.	piperine	64-72	butyrylcholinesterase	Homo sapiens	108-122
33062432-9	2020	We revealed that curcumin and piperine have displayed their actions against Abeta via the modulation of various mechanistic pathways.	piperine	30-38	amyloid beta precursor protein	Homo sapiens	76-81
33062432-10	2020	Alterations in expression profiles of genes in the neuronal cell model may explain Abeta pathology post-treatment and provide new insights for remedial approaches of a combined treatment using curcumin and piperine.	piperine	206-214	amyloid beta precursor protein	Homo sapiens	83-88
32967203-0	2020	Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats.	piperine	0-8	NFE2 like bZIP transcription factor 2	Rattus norvegicus	19-24
32967203-0	2020	Piperine Regulates Nrf-2/Keap-1 Signalling and Exhibits Anticancer Effect in Experimental Colon Carcinogenesis in Wistar Rats.	piperine	0-8	Kelch-like ECH-associated protein 1	Rattus norvegicus	25-31
32967203-12	2020	Our results indicate that piperine may be an effective molecule for the prophylactic treatment of colon carcinogenesis by targeting the NF-kappaB/Nrf-2/Keap-1/HO-1 pathway as a progressive strategy in the preclusion and effective treatment of colorectal cancer.	piperine	26-34	nuclear factor kappa B subunit 1	Homo sapiens	136-145
32967203-12	2020	Our results indicate that piperine may be an effective molecule for the prophylactic treatment of colon carcinogenesis by targeting the NF-kappaB/Nrf-2/Keap-1/HO-1 pathway as a progressive strategy in the preclusion and effective treatment of colorectal cancer.	piperine	26-34	NFE2 like bZIP transcription factor 2	Homo sapiens	146-151
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	nuclear factor kappa B subunit 1	Homo sapiens	33-42
32967203-12	2020	Our results indicate that piperine may be an effective molecule for the prophylactic treatment of colon carcinogenesis by targeting the NF-kappaB/Nrf-2/Keap-1/HO-1 pathway as a progressive strategy in the preclusion and effective treatment of colorectal cancer.	piperine	26-34	kelch like ECH associated protein 1	Homo sapiens	152-158
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	NFE2 like bZIP transcription factor 2	Homo sapiens	64-69
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	tumor necrosis factor	Homo sapiens	125-134
32967203-12	2020	Our results indicate that piperine may be an effective molecule for the prophylactic treatment of colon carcinogenesis by targeting the NF-kappaB/Nrf-2/Keap-1/HO-1 pathway as a progressive strategy in the preclusion and effective treatment of colorectal cancer.	piperine	26-34	heme oxygenase 1	Homo sapiens	159-163
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	interleukin 6	Homo sapiens	136-140
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	interleukin 1 alpha	Homo sapiens	142-150
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	152-157
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	inositol-3-phosphate synthase 1	Homo sapiens	166-170
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	myeloperoxidase	Homo sapiens	176-179
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	heme oxygenase 1	Homo sapiens	228-232
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	NAD(P)H quinone dehydrogenase 1	Homo sapiens	234-239
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	catalase	Homo sapiens	255-258
32967203-9	2020	We found that piperine inhibited NF-kappaB by the activation of Nrf-2, blocking downstream inflammatory mediators/cytokines (TNF-alpha, IL-6, IL-1beta, Cox-2, PGE-2, iNOS, NO, MPO), triggering an antioxidant response machinery (HO-1, NQO-1, GSH, GR, GPx, CAT, SOD), scavenging ROS, and decreasing lipid peroxidation.	piperine	14-22	superoxide dismutase 1	Homo sapiens	260-263
32335165-10	2020	Piperine inhibited iNOS expression concomitant with enhanced expression levels of Nrf2, HO1 and the total antioxidant capacity in the hippocampal tissue.	piperine	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	82-86
32962126-1	2020	The bioactive piperine, a compound found in some pepper species, has been widely studied because of its therapeutic properties that include the inhibition of an important inflammation pathway triggered by interleukin-1 beta (IL-1beta).	piperine	14-22	interleukin 1 beta	Homo sapiens	205-223
32962126-1	2020	The bioactive piperine, a compound found in some pepper species, has been widely studied because of its therapeutic properties that include the inhibition of an important inflammation pathway triggered by interleukin-1 beta (IL-1beta).	piperine	14-22	interleukin 1 alpha	Homo sapiens	225-233
32962126-2	2020	However, investigation into the molecular interactions between IL-1beta and piperine is not reported in the literature.	piperine	76-84	interleukin 1 alpha	Homo sapiens	63-71
32962126-3	2020	Here, we present for the first time the characterisation of the complex formed by IL-1beta and piperine through experimental and computational molecular biophysical analyses.	piperine	95-103	interleukin 1 alpha	Homo sapiens	82-90
32962126-4	2020	Fluorescence spectroscopy unveiled the presence of one binding site for piperine with an affinity constant of 14.3 x 104 M-1 at 298 K. The thermodynamic analysis indicated that the interaction with IL-1beta was spontaneous ( G = -25 kJ/mol) and, when split into enthalpic and entropic contributions, the latter was more significant.	piperine	72-80	interleukin 1 alpha	Homo sapiens	198-206
32402936-0	2020	Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson"s disease via the activation of Nrf2/keap1 pathway.	piperine	35-43	NFE2 like bZIP transcription factor 2	Rattus norvegicus	143-147
32402936-0	2020	Identification and optimization of piperine analogues as neuroprotective agents for the treatment of Parkinson"s disease via the activation of Nrf2/keap1 pathway.	piperine	35-43	Kelch-like ECH-associated protein 1	Rattus norvegicus	148-153
31183672-1	2020	A facile, multicomponent (MCR) atom-economic synthesis of novel spiro-oxindolo pyrrolizidine adducts of piperine has been achieved via an intermolecular 1,3-dipolar azomethine ylide cycloaddition reaction.	piperine	104-112	nuclear receptor subfamily 3 group C member 2	Homo sapiens	26-29
32851010-4	2020	Moreover, the piglets in the CUR + PIP and high-CUR groups had higher serum and intestinal mucosa activity of superoxide dismutase and glutathione peroxidase and lower malonaldehyde concentration than piglets in the CON group (all P < 0.05).	piperine	35-38	probable phospholipid hydroperoxide glutathione peroxidase	Glycine max	135-157
32721999-0	2020	Resveratrol, Curcumin and Piperine Alter Human Glyoxalase 1 in MCF-7 Breast Cancer Cells.	piperine	26-34	glyoxalase I	Homo sapiens	47-59
32721999-4	2020	In this scenario, the aim of this study was to investigate the effects of the bioactive compounds resveratrol, curcumin and piperine (R-C-P) on MCF-7 breast cancer cells and to associate them to Glyoxalase 1 (GLO1) activity.	piperine	124-132	glyoxalase I	Homo sapiens	195-207
32721999-4	2020	In this scenario, the aim of this study was to investigate the effects of the bioactive compounds resveratrol, curcumin and piperine (R-C-P) on MCF-7 breast cancer cells and to associate them to Glyoxalase 1 (GLO1) activity.	piperine	124-132	glyoxalase I	Homo sapiens	209-213
32938313-8	2022	We have found that though all the molecules bind actively with the SARS-CoV-2 RBD Spro and Mpro, but Piperine has the highest binding affinity among the 30 screened molecules.	piperine	101-109	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	91-95
32938313-10	2022	The interaction of Piperine with RBD Spro and Mpro is further validated by the molecular dynamics (MD) simulation studies.	piperine	19-27	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	46-50
32938313-11	2022	The free energy landscape and binding free energy results also, support for the stable complex formation of Piperine with RBD Spro and Mpro.	piperine	108-116	NEWENTRY	Severe acute respiratory syndrome-related coronavirus	135-139
32335165-10	2020	Piperine inhibited iNOS expression concomitant with enhanced expression levels of Nrf2, HO1 and the total antioxidant capacity in the hippocampal tissue.	piperine	0-8	inositol-3-phosphate synthase 1	Homo sapiens	19-23
32335165-10	2020	Piperine inhibited iNOS expression concomitant with enhanced expression levels of Nrf2, HO1 and the total antioxidant capacity in the hippocampal tissue.	piperine	0-8	heme oxygenase 1	Homo sapiens	88-91
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	tumor necrosis factor	Homo sapiens	70-79
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	interleukin 1 alpha	Homo sapiens	81-89
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	91-100
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	interleukin 10	Homo sapiens	171-176
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	forkhead box P3	Homo sapiens	178-183
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	brain derived neurotrophic factor	Homo sapiens	185-189
32335165-11	2020	Piperine treatment significantly reduced the gene expression level of TNF-alpha, IL1-beta, NF-kappaB, and glial activation in the injured area; however, the mRNA level of IL-10, Foxp3, BDNF and MBP were significantly increased.	piperine	0-8	myelin basic protein	Homo sapiens	194-197
32575582-0	2020	Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1beta and NF-kappaB Proteins.	piperine	40-48	interleukin 1 alpha	Homo sapiens	137-145
32614754-0	2021	Piperine from Black Pepper Decreased the Expression of Intercellular Adhesion Molecule-1 in Macrophages.	piperine	0-8	intercellular adhesion molecule 1	Mus musculus	55-88
32614754-4	2021	In current study, the possible anti-inflammatory effect of piperine on the expression of ICAM-1 on J774.1 murine macrophage cell line was investigated.	piperine	59-67	intercellular adhesion molecule 1	Mus musculus	89-95
32614754-6	2021	RESULTS: We found that piperine decreased ICAM-1 gene expression level from 2.4 +- 0.25 RFC (relative fold change) in LPS-only treated cells to 0.85 +- 0.525 RFC at 1mug/ml (p<0.05), 0.43 +- 0.27 RFC at 10mug/ml (p<0.01), and 0.26 +- 0.25 RFC at 20mug/ml (p<0.01).	piperine	23-31	intercellular adhesion molecule 1	Mus musculus	42-48
32614754-7	2021	In flow cytometry, piperine at all concentrations significantly decreased ICAM-1 surface expressions (P<0.05).	piperine	19-27	intercellular adhesion molecule 1	Mus musculus	74-80
32614754-9	2021	CONCLUSION: According to the results of this study, by decreasing the expression of ICAM-1, piperine is suggested as a candidate to reduce inflammation and has the potential for therapeutic benefits for immune-mediated diseases.	piperine	92-100	intercellular adhesion molecule 1	Mus musculus	84-90
32353424-0	2020	Natural Product Piperine Alleviates Experimental Allergic Encephalomyelitis in Mice by Targeting Dihydroorotate Dehydrogenase.	piperine	16-24	dihydroorotate dehydrogenase	Mus musculus	97-125
32353424-3	2020	Here we identify piperine, a bioactive constituent of black pepper, as a potent inhibitor of DHODH with an IC50 value of 0.88 muM.	piperine	17-25	dihydroorotate dehydrogenase	Mus musculus	93-98
32353424-4	2020	Isothermal titration calorimetry and thermofluor assay demonstrate the directly interaction between piperine and DHODH.	piperine	100-108	dihydroorotate dehydrogenase	Mus musculus	113-118
32353424-5	2020	The co-complex crystal structure of DHODH and piperine at 1.98 A resolution further reveal that Tyr356 residue of DHODH is crucial for piperine binding.	piperine	46-54	dihydroorotate dehydrogenase	Mus musculus	114-119
32353424-5	2020	The co-complex crystal structure of DHODH and piperine at 1.98 A resolution further reveal that Tyr356 residue of DHODH is crucial for piperine binding.	piperine	135-143	dihydroorotate dehydrogenase	Mus musculus	36-41
32353424-5	2020	The co-complex crystal structure of DHODH and piperine at 1.98 A resolution further reveal that Tyr356 residue of DHODH is crucial for piperine binding.	piperine	135-143	dihydroorotate dehydrogenase	Mus musculus	114-119
32353424-6	2020	Importantly, we show that piperine can inhibit T cell overactivation in a DHODH-dependent manner in concanavalin A-triggered T-cell assay and mixed lymphocyte reaction assay.	piperine	26-34	dihydroorotate dehydrogenase	Mus musculus	74-79
32353424-7	2020	Finally, piperine exhibits strong preventive and therapeutic effect in the MOG-induced experimental allergic encephalomyelitis (EAE), a useful model for studying potential treatments for MS, by restricting inflammatory cells infiltration into the CNS and preventing myelin destruction and blood-brain barrier (BBB) disruption.	piperine	9-17	myelin oligodendrocyte glycoprotein	Mus musculus	75-78
32884209-0	2020	Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9.	piperine	26-34	BCL2 associated X, apoptosis regulator	Homo sapiens	40-43
32884209-0	2020	Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9.	piperine	26-34	caspase 3	Homo sapiens	45-54
32884209-0	2020	Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9.	piperine	26-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
32884209-0	2020	Molecular docking data of piperine with Bax, Caspase 3, Cox 2 and Caspase 9.	piperine	26-34	caspase 9	Homo sapiens	66-75
32669593-0	2020	Piperine suppresses the Wnt/beta-catenin pathway and has anti-cancer effects on colorectal cancer cells.	piperine	0-8	catenin beta 1	Homo sapiens	28-40
32669593-5	2020	By using Wnt/beta-catenin pathway epistasis experiment we show that piperine inhibits the canonical Wnt pathway induced by overexpression of beta-catenin, beta-catenin S33A or dnTCF4 VP16, while also suppressing beta-catenin nuclear localization in HCT116 cell line.	piperine	68-76	catenin beta 1	Homo sapiens	13-25
32669593-5	2020	By using Wnt/beta-catenin pathway epistasis experiment we show that piperine inhibits the canonical Wnt pathway induced by overexpression of beta-catenin, beta-catenin S33A or dnTCF4 VP16, while also suppressing beta-catenin nuclear localization in HCT116 cell line.	piperine	68-76	catenin beta 1	Homo sapiens	141-153
32669593-5	2020	By using Wnt/beta-catenin pathway epistasis experiment we show that piperine inhibits the canonical Wnt pathway induced by overexpression of beta-catenin, beta-catenin S33A or dnTCF4 VP16, while also suppressing beta-catenin nuclear localization in HCT116 cell line.	piperine	68-76	catenin beta 1	Homo sapiens	141-153
32669593-5	2020	By using Wnt/beta-catenin pathway epistasis experiment we show that piperine inhibits the canonical Wnt pathway induced by overexpression of beta-catenin, beta-catenin S33A or dnTCF4 VP16, while also suppressing beta-catenin nuclear localization in HCT116 cell line.	piperine	68-76	catenin beta 1	Homo sapiens	141-153
32575582-0	2020	Synthesis and Spectroscopic Analysis of Piperine- and Piperlongumine-Inspired Natural Product Scaffolds and Their Molecular Docking with IL-1beta and NF-kappaB Proteins.	piperine	40-48	nuclear factor kappa B subunit 1	Homo sapiens	150-159
32655468-9	2020	Our data show that piperine treatment can reduce the degree of cerebral edema, down-regulate TNF-alpha, IL-1beta, and BDNF, decrease the reactivity of GFAP in the hippocampus, and inhibit TBI-induced seizures.	piperine	19-27	interleukin 1 alpha	Mus musculus	104-112
32551384-1	2020	Piperine-rich herbal mixture (PHM) used in this study is a traditional Thai medicine that contains 21 oriental herbs.	piperine	0-8	peptidylglycine alpha-amidating monooxygenase	Mus musculus	30-33
32551384-4	2020	It contains Piper nigrum fruits as a major constituent and also Piper retrofractum fruits, PHM thus has anti-inflammatory activities that mostly come from the bioactivities of piperine consisting of these pepper fruits.	piperine	176-184	peptidylglycine alpha-amidating monooxygenase	Mus musculus	91-94
32551384-13	2020	The release profile of piperine from PHM-E film followed a zero-kinetic model.	piperine	23-31	peptidylglycine alpha-amidating monooxygenase	Mus musculus	37-42
32655468-6	2020	The western blot results showed that the expression levels of inflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were reduced by piperine.	piperine	172-180	tumor necrosis factor	Mus musculus	83-110
32655468-9	2020	Our data show that piperine treatment can reduce the degree of cerebral edema, down-regulate TNF-alpha, IL-1beta, and BDNF, decrease the reactivity of GFAP in the hippocampus, and inhibit TBI-induced seizures.	piperine	19-27	brain derived neurotrophic factor	Mus musculus	118-122
32655468-6	2020	The western blot results showed that the expression levels of inflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were reduced by piperine.	piperine	172-180	tumor necrosis factor	Mus musculus	112-121
32655468-6	2020	The western blot results showed that the expression levels of inflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were reduced by piperine.	piperine	172-180	interleukin 1 beta	Mus musculus	127-144
32655468-9	2020	Our data show that piperine treatment can reduce the degree of cerebral edema, down-regulate TNF-alpha, IL-1beta, and BDNF, decrease the reactivity of GFAP in the hippocampus, and inhibit TBI-induced seizures.	piperine	19-27	glial fibrillary acidic protein	Mus musculus	151-155
32655468-6	2020	The western blot results showed that the expression levels of inflammatory factors tumor necrosis factor-alpha (TNF-alpha) and interleukin-1beta (IL-1beta) were reduced by piperine.	piperine	172-180	interleukin 1 alpha	Mus musculus	146-154
32193099-0	2020	HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.	piperine	28-36	Kelch-like ECH-associated protein 1	Rattus norvegicus	187-192
32655468-7	2020	The immunostaining results showed that the brain-derived neurotrophic factor (BDNF) was also reduced by piperine.	piperine	104-112	brain derived neurotrophic factor	Mus musculus	43-76
32655468-7	2020	The immunostaining results showed that the brain-derived neurotrophic factor (BDNF) was also reduced by piperine.	piperine	104-112	brain derived neurotrophic factor	Mus musculus	78-82
32655468-9	2020	Our data show that piperine treatment can reduce the degree of cerebral edema, down-regulate TNF-alpha, IL-1beta, and BDNF, decrease the reactivity of GFAP in the hippocampus, and inhibit TBI-induced seizures.	piperine	19-27	tumor necrosis factor	Mus musculus	93-102
32193099-0	2020	HJ22, a Novel derivative of piperine, Attenuates ibotenic acid-induced cognitive impairment, oxidativestress, apoptosis and inflammation via inhibiting the protein-protein interaction of Keap1-Nrf2.	piperine	28-36	NFE2 like bZIP transcription factor 2	Rattus norvegicus	193-197
32193099-2	2020	In this study, we found a novel piperine derivative (HJ22) synthesized by our group with great ability to bind to Keap-1 and activate Keap1-Nrf2-ARE signaling pathway in vitro, driving us to investigate the beneficial effects of HJ22 on ibotenic acid (IBO)-induced neurological disorders in rats and underlying mechanisms.	piperine	32-40	Kelch-like ECH-associated protein 1	Rattus norvegicus	114-120
32193099-2	2020	In this study, we found a novel piperine derivative (HJ22) synthesized by our group with great ability to bind to Keap-1 and activate Keap1-Nrf2-ARE signaling pathway in vitro, driving us to investigate the beneficial effects of HJ22 on ibotenic acid (IBO)-induced neurological disorders in rats and underlying mechanisms.	piperine	32-40	Kelch-like ECH-associated protein 1	Rattus norvegicus	134-139
32193099-2	2020	In this study, we found a novel piperine derivative (HJ22) synthesized by our group with great ability to bind to Keap-1 and activate Keap1-Nrf2-ARE signaling pathway in vitro, driving us to investigate the beneficial effects of HJ22 on ibotenic acid (IBO)-induced neurological disorders in rats and underlying mechanisms.	piperine	32-40	NFE2 like bZIP transcription factor 2	Rattus norvegicus	140-144
32392825-0	2020	Piperine Ameliorates Trimellitic Anhydride-Induced Atopic Dermatitis-Like Symptoms by Suppressing Th2-Mediated Immune Responses via Inhibition of STAT6 Phosphorylation.	piperine	0-8	signal transducer and activator of transcription 6	Mus musculus	146-151
32440910-2	2020	The combination of paclitaxel (PTX) and piperine (PIP) may improve the bioavailability of paclitaxel for cancer therapy.	piperine	40-48	prolactin induced protein	Homo sapiens	50-53
31989711-0	2020	The anti-anaphylactoid effects of Piperine through regulating MAS-related G protein-coupled receptor X2 activation.	piperine	34-42	MAS-related GPR, member X2	Mus musculus	62-103
31989711-11	2020	The results showed that Piperine suppressed mast cell intracellular Ca2+ mobilization, inhibited cytokines and chemokines release, and down-regulated the phosphorylation level of phospholipase Cgamma1, protein kinase C, inositol 1,4,5-triphate receptor, P38, protein kinase B, and ERK.	piperine	24-32	phospholipase C, gamma 1	Mus musculus	179-200
31989711-11	2020	The results showed that Piperine suppressed mast cell intracellular Ca2+ mobilization, inhibited cytokines and chemokines release, and down-regulated the phosphorylation level of phospholipase Cgamma1, protein kinase C, inositol 1,4,5-triphate receptor, P38, protein kinase B, and ERK.	piperine	24-32	mitogen-activated protein kinase 14	Mus musculus	254-257
31989711-11	2020	The results showed that Piperine suppressed mast cell intracellular Ca2+ mobilization, inhibited cytokines and chemokines release, and down-regulated the phosphorylation level of phospholipase Cgamma1, protein kinase C, inositol 1,4,5-triphate receptor, P38, protein kinase B, and ERK.	piperine	24-32	mitogen-activated protein kinase 1	Mus musculus	281-284
31989711-12	2020	Meanwhile, Piperine can bind to MRGPRX2 as a specific antagonist.	piperine	11-19	MAS-related GPR, member X2	Mus musculus	32-39
31989711-13	2020	Hence, Piperine can be served as a novel therapeutic drug candidate for MRGPRX2-mediated anaphylactoid reactions.	piperine	7-15	MAS-related GPR, member X2	Mus musculus	72-79
32656311-10	2020	Our study exhibited that curcumin, nimbin, withaferin A, piperine, mangiferin, thebaine, berberine, and andrographolide have significant binding affinity towards spike glycoprotein of SARS-CoV-2 and ACE2 receptor and may be useful as a therapeutic and/or prophylactic agent for restricting viral attachment to the host cells.	piperine	57-65	angiotensin converting enzyme 2	Homo sapiens	199-203
32546971-0	2020	Synthesis and Biological Activity of Piperine Derivatives as Potential PPARgamma Agonists.	piperine	37-45	peroxisome proliferator activated receptor gamma	Homo sapiens	71-80
32546971-3	2020	Materials and Methods: In the research, we synthesized a series of piperine derivatives and then used a fluorescence polarization-based PPARgamma ligand screening assay to evaluate the agonistic activity of PPARgamma.	piperine	67-75	peroxisome proliferator activated receptor gamma	Homo sapiens	207-216
32546971-10	2020	Molecular docking studies indicated that the piperine derivative 2a stably interacts with the amino acid residues of the PPARgamma complex active site, which is consistent with the results of the in vitro PPARgamma ligand screening assay.	piperine	45-53	peroxisome proliferator activated receptor gamma	Homo sapiens	121-130
32546971-10	2020	Molecular docking studies indicated that the piperine derivative 2a stably interacts with the amino acid residues of the PPARgamma complex active site, which is consistent with the results of the in vitro PPARgamma ligand screening assay.	piperine	45-53	peroxisome proliferator activated receptor gamma	Homo sapiens	205-214
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	140-148	C-C motif chemokine receptor 3	Homo sapiens	291-295
32392825-7	2020	These results demonstrate that piperine could ameliorate AD symptoms through suppression of Th2-mediated immune responses, including the STAT6/GATA3/IL-4 signaling pathway.	piperine	31-39	signal transducer and activator of transcription 6	Homo sapiens	137-142
32392825-7	2020	These results demonstrate that piperine could ameliorate AD symptoms through suppression of Th2-mediated immune responses, including the STAT6/GATA3/IL-4 signaling pathway.	piperine	31-39	GATA binding protein 3	Mus musculus	143-148
32392825-7	2020	These results demonstrate that piperine could ameliorate AD symptoms through suppression of Th2-mediated immune responses, including the STAT6/GATA3/IL-4 signaling pathway.	piperine	31-39	interleukin 4	Homo sapiens	149-153
32392825-8	2020	Therefore, we suggest that piperine is an excellent candidate as an inhibitor of STAT6 and may help to improve AD symptoms.	piperine	27-35	signal transducer and activator of transcription 6	Homo sapiens	81-86
32392825-4	2020	Furthermore, piperine inhibited pro-inflammatory cytokines such as TNF-alpha and IL-1beta in mouse ears, compared with the TMA-induced AD group.	piperine	13-21	tumor necrosis factor	Mus musculus	67-76
32392825-4	2020	Furthermore, piperine inhibited pro-inflammatory cytokines such as TNF-alpha and IL-1beta in mouse ears, compared with the TMA-induced AD group.	piperine	13-21	interleukin 1 alpha	Mus musculus	81-89
32392825-5	2020	In measuring allergic immune responses in draining lymph nodes (dLNs), we found that IL-4 secretion, GATA3 mRNA level, and STAT6 phosphorylation were suppressed by piperine treatment.	piperine	164-172	interleukin 4	Mus musculus	85-89
32392825-5	2020	In measuring allergic immune responses in draining lymph nodes (dLNs), we found that IL-4 secretion, GATA3 mRNA level, and STAT6 phosphorylation were suppressed by piperine treatment.	piperine	164-172	GATA binding protein 3	Mus musculus	101-106
32392825-5	2020	In measuring allergic immune responses in draining lymph nodes (dLNs), we found that IL-4 secretion, GATA3 mRNA level, and STAT6 phosphorylation were suppressed by piperine treatment.	piperine	164-172	signal transducer and activator of transcription 6	Mus musculus	123-128
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	21-29	signal transducer and activator of transcription 6	Mus musculus	68-73
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	21-29	CD4 antigen	Mus musculus	81-84
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	21-29	interleukin 4	Mus musculus	160-164
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	21-29	chemokine (C-C motif) ligand 26	Mus musculus	173-178
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	21-29	signal transducer and activator of transcription 6	Mus musculus	199-204
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	21-29	C-C motif chemokine receptor 3	Homo sapiens	291-295
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	140-148	interleukin 4	Mus musculus	160-164
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	140-148	chemokine (C-C motif) ligand 26	Mus musculus	173-178
32392825-6	2020	In an ex vivo study, piperine also inhibited the phosphorylation of STAT6 on the CD4+ T cells isolated from splenocytes of BALB/c mice, and piperine suppressed IL-4-induced CCL26 mRNA expression and STAT6 phosphorylation in human keratinocytes resulting in the inhibition of infiltration of CCR3+ cells into inflammatory lesions.	piperine	140-148	signal transducer and activator of transcription 6	Mus musculus	199-204
32357811-3	2020	In thecase of MAO-B the rhamnetin, quercetin, piperine, eugenol,and umbelliferone exhibited highest dock score -10.57, -9.938, -9.445, - 8.757and 7.821respectively.	piperine	46-54	monoamine oxidase B	Homo sapiens	14-19
32323765-0	2020	Wnt/beta-catenin signaling modulates piperine-mediated antitumor effects on human osteosarcoma cells.	piperine	37-45	catenin beta 1	Homo sapiens	4-16
32323765-9	2020	Therefore, the present study demonstrated the efficacy of piperine in osteosarcoma, and identified that the Wnt/beta-catenin signaling pathway may modulate the antitumor effects of piperine on human U2OS and 143B cells.	piperine	181-189	catenin beta 1	Homo sapiens	112-124
32323765-4	2020	Moreover, western blotting was used to measure the effects of piperine on the protein expression levels of the metastasis markers matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF).	piperine	62-70	matrix metallopeptidase 2	Homo sapiens	130-156
32323765-4	2020	Moreover, western blotting was used to measure the effects of piperine on the protein expression levels of the metastasis markers matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF).	piperine	62-70	matrix metallopeptidase 2	Homo sapiens	158-163
32323765-4	2020	Moreover, western blotting was used to measure the effects of piperine on the protein expression levels of the metastasis markers matrix metalloproteinase-2 (MMP-2) and vascular endothelial growth factor (VEGF).	piperine	62-70	vascular endothelial growth factor A	Homo sapiens	169-203
32323765-5	2020	In addition, the involvement of the Wnt/beta-catenin signaling pathway in modulating the effects of piperine was examined via western blot analysis.	piperine	100-108	catenin beta 1	Homo sapiens	40-52
30796508-2	2020	The present study aimed to explore the effect of phosphatidylserine- and piperine-containing curcumin phytosomes on a large number of metabolic parameters related to insulin resistance, in the context of a randomized double-blind placebo-controlled trial involving 80 overweight subjects with suboptimal fasting plasma glucose.	piperine	73-81	insulin	Homo sapiens	166-173
32276474-0	2020	Piperine Inhibits TGF-beta Signaling Pathways and Disrupts EMT-Related Events in Human Lung Adenocarcinoma Cells.	piperine	0-8	transforming growth factor alpha	Homo sapiens	18-26
32276474-10	2020	In order to investigate whether piperine would reverse the TGF-beta1 induced-EMT, the A549 cell line was pretreated with sublethal concentrations of the natural amide followed by the addition of TGF-beta1.	piperine	32-40	transforming growth factor beta 1	Homo sapiens	59-68
32276474-11	2020	Besides disrupting EMT-related events, piperine also inhibited both ERK 1/2 and SMAD 2 phosphorylation.	piperine	39-47	mitogen-activated protein kinase 3	Homo sapiens	68-75
31835924-0	2020	Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IkappaB-alpha/NF-kappaB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice.	piperine	0-8	claudin 1	Mus musculus	179-188
31835924-0	2020	Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IkappaB-alpha/NF-kappaB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice.	piperine	0-8	occludin	Mus musculus	190-198
31835924-0	2020	Piperine, a functional food alkaloid, exhibits inhibitory potential against TNBS-induced colitis via the inhibition of IkappaB-alpha/NF-kappaB and induces tight junction protein (claudin-1, occludin, and ZO-1) signaling pathway in experimental mice.	piperine	0-8	tight junction protein 1	Mus musculus	204-208
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	piperine	12-20	tumor necrosis factor	Rattus norvegicus	281-290
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	piperine	12-20	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	302-307
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	piperine	12-20	nitric oxide synthase 2	Rattus norvegicus	309-313
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	piperine	12-20	caspase 1	Rattus norvegicus	368-377
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	piperine	12-20	claudin 1	Rattus norvegicus	426-435
32276474-11	2020	Besides disrupting EMT-related events, piperine also inhibited both ERK 1/2 and SMAD 2 phosphorylation.	piperine	39-47	SMAD family member 2	Homo sapiens	80-86
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	piperine	12-20	occludin	Rattus norvegicus	437-445
31835924-14	2020	CONCLUSION: Piperine ameliorated the progression of TNBS-induced colitis by modulating the nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-alpha/nuclear factor-kappa B signaling pathway, thus inhibiting the overexpression of proinflammatory cytokines (TNF-alpha and IL"s), COX-2, iNOs, oxido-nitrosative stress, and proapoptotic proteins (caspase-1) that may improve the expression of TJ protein (claudin-1, occludin, and ZO-1).	piperine	12-20	tight junction protein 1	Rattus norvegicus	451-455
31732838-7	2020	The increased IFN-alpha, IL-6 and TNF-alpha was mitigated by low dose of resveratrol and piperine (RP-1).	piperine	89-97	interferon alpha	Mus musculus	14-23
31732838-7	2020	The increased IFN-alpha, IL-6 and TNF-alpha was mitigated by low dose of resveratrol and piperine (RP-1).	piperine	89-97	interleukin 6	Mus musculus	25-29
31732838-7	2020	The increased IFN-alpha, IL-6 and TNF-alpha was mitigated by low dose of resveratrol and piperine (RP-1).	piperine	89-97	tumor necrosis factor	Mus musculus	34-43
31748224-10	2020	It appears that both carbene and ortho-quinone intermediates were involved in the inactivation of CYP3A caused by PPR.	piperine	114-117	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-103
32093571-11	2022	In addition, astrocytes activation was observed by GFAP immunostaining.Results: Our results showed that 3-NP induced behavioral impairments are attenuated by PIP co-treatment.	piperine	158-161	glial fibrillary acidic protein	Rattus norvegicus	51-55
32099971-4	2020	In the current study we have prepared a series of compounds related to piperine and investigated them through monoamine oxidase A and B assay and evaluated the free radical scavenging activity.	piperine	71-79	monoamine oxidase A	Homo sapiens	110-129
31748224-0	2020	Piperine is a Mechanism-based inactivator of CYP3A.	piperine	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	45-50
31748224-13	2020	PPR revealed time- and concentration-, and NADPH-dependent inhibitory effect on CYP3A.	piperine	0-3	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	80-85
31748224-14	2020	Carbene and quinone metabolites were both involved in the observed CYP3A inactivation by PPR.	piperine	89-92	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	67-72
31748224-2	2020	Our rapid screening study found PPR caused time-dependent inhibition of cytochrome P450s (CYP) 3A and 2D6, and CYP3A was inactivated the most.	piperine	32-35	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	72-105
31748224-2	2020	Our rapid screening study found PPR caused time-dependent inhibition of cytochrome P450s (CYP) 3A and 2D6, and CYP3A was inactivated the most.	piperine	32-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	111-116
32277661-9	2020	Further, it was observed that the anticancer effects of piperine and curcumin were due to the induction of mitochondrial-mediated apoptosis which was also associated with enhancement of the Bax expression.	piperine	56-64	BCL2 associated X, apoptosis regulator	Homo sapiens	190-193
31748224-3	2020	Further study demonstrated PPR is a time-, concentration-, and NADPH-dependent inhibitor of CYP3A, and significant loss (49.5 &amp;plusmn 3.9%) of CYP3A activity was observed after 20 min incubations with 80 muM PPR at 37  C. The values of K I and k inact were 30.7 muM and 0.041 min-1, respectively.	piperine	27-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	92-97
31748224-3	2020	Further study demonstrated PPR is a time-, concentration-, and NADPH-dependent inhibitor of CYP3A, and significant loss (49.5 &amp;plusmn 3.9%) of CYP3A activity was observed after 20 min incubations with 80 muM PPR at 37  C. The values of K I and k inact were 30.7 muM and 0.041 min-1, respectively.	piperine	27-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	147-152
31748224-3	2020	Further study demonstrated PPR is a time-, concentration-, and NADPH-dependent inhibitor of CYP3A, and significant loss (49.5 &amp;plusmn 3.9%) of CYP3A activity was observed after 20 min incubations with 80 muM PPR at 37  C. The values of K I and k inact were 30.7 muM and 0.041 min-1, respectively.	piperine	212-215	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	92-97
31748224-3	2020	Further study demonstrated PPR is a time-, concentration-, and NADPH-dependent inhibitor of CYP3A, and significant loss (49.5 &amp;plusmn 3.9%) of CYP3A activity was observed after 20 min incubations with 80 muM PPR at 37  C. The values of K I and k inact were 30.7 muM and 0.041 min-1, respectively.	piperine	212-215	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	147-152
31748224-8	2020	An ortho-quinone intermediate was trapped by NAC in microsomal incubations with PPR.	piperine	80-83	synuclein alpha	Homo sapiens	45-48
31711793-0	2020	Design of novel monoamine oxidase-B inhibitors based on piperine scaffold: Structure-activity-toxicity, drug-likeness and efflux transport studies.	piperine	56-64	monoamine oxidase B	Homo sapiens	16-35
31711793-2	2020	Accordingly, we prepared a small library of piperine derivatives and screened the inhibitory activities towards human MAO isoforms (hMAO-A and hMAO-B).	piperine	44-52	monoamine oxidase B	Homo sapiens	143-149
31711793-6	2020	Compound 15 stands out as the most potent piperine-based hMAO-B inhibitor (IC50 = 47.4 nM), displaying favourable drug-like properties and a broad safety window.	piperine	42-50	monoamine oxidase B	Homo sapiens	57-63
31724938-10	2019	Subgroup analyses displayed that curcumin could significantly reduce MDA levels with or without use of piperine, however it could increase SOD level in presence of piperine.	piperine	164-172	superoxide dismutase 1	Homo sapiens	139-142
32657210-6	2020	The piperine at 300 microg mL-1 produced higher radial growth inhibition (89%) and aflatoxin production inhibition (69%).	piperine	4-12	L1 cell adhesion molecule	Mus musculus	27-31
31710934-0	2020	Piperine regulates glycogen synthase kinase-3beta-related signaling and attenuates cognitive decline in D-galactose-induced aging mouse model.	piperine	0-8	glycogen synthase kinase 3 beta	Mus musculus	19-49
31710934-11	2020	Moreover, piperine also reversed D-Gal-induced GSK-3beta activation through modulating PKC and PI3K/AKT pathways in senescent mouse hippocampus, suggesting GSK-3beta-related signaling might be involved in the benefits of piperine against D-Gal-induced cognitive decline in mice.	piperine	10-18	glycogen synthase kinase 3 beta	Mus musculus	47-56
31710934-11	2020	Moreover, piperine also reversed D-Gal-induced GSK-3beta activation through modulating PKC and PI3K/AKT pathways in senescent mouse hippocampus, suggesting GSK-3beta-related signaling might be involved in the benefits of piperine against D-Gal-induced cognitive decline in mice.	piperine	10-18	thymoma viral proto-oncogene 1	Mus musculus	100-103
31710934-11	2020	Moreover, piperine also reversed D-Gal-induced GSK-3beta activation through modulating PKC and PI3K/AKT pathways in senescent mouse hippocampus, suggesting GSK-3beta-related signaling might be involved in the benefits of piperine against D-Gal-induced cognitive decline in mice.	piperine	10-18	glycogen synthase kinase 3 beta	Mus musculus	156-165
31933619-0	2019	Piperine Alleviates Doxorubicin-Induced Cardiotoxicity via Activating PPAR-gamma in Mice.	piperine	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	70-80
31933619-10	2019	We also found that piperine activated peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and the protective effects of piperine were abolished by the treatment of the PPAR-gamma antagonist in vivo and in vitro.	piperine	19-27	peroxisome proliferator activated receptor gamma	Mus musculus	38-86
31933619-10	2019	We also found that piperine activated peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and the protective effects of piperine were abolished by the treatment of the PPAR-gamma antagonist in vivo and in vitro.	piperine	19-27	peroxisome proliferator activated receptor gamma	Mus musculus	88-98
31933619-10	2019	We also found that piperine activated peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and the protective effects of piperine were abolished by the treatment of the PPAR-gamma antagonist in vivo and in vitro.	piperine	19-27	peroxisome proliferator activated receptor gamma	Mus musculus	179-189
31933619-10	2019	We also found that piperine activated peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and the protective effects of piperine were abolished by the treatment of the PPAR-gamma antagonist in vivo and in vitro.	piperine	131-139	peroxisome proliferator activated receptor gamma	Mus musculus	179-189
31933619-11	2019	Conclusions: Piperine could suppress DOX-related cardiac injury via activation of PPAR-gamma in mice.	piperine	13-21	peroxisome proliferator activated receptor gamma	Mus musculus	82-92
31627104-1	2019	The present work aimed to accomplish a comparative and principled study on desolvation and self-assembly methods for synthesis of piperine-loaded human serum albumin nanoparticles (PIP-HSA-NPs).	piperine	130-138	prolactin induced protein	Homo sapiens	181-184
31368246-8	2019	Full scan MS followed by data-dependent MS2 (Full MS-ddMS2 ) mode was used to establish mass spectrometric fragmentation pathways of protonated piperine and its metabolites.	piperine	144-152	MS2	Homo sapiens	40-43
31983100-0	2019	Piperine alkaloid induces anticancer and apoptotic effects in cisplatin resistant ovarian carcinoma by inducing G2/M phase cell cycle arrest, caspase activation and inhibition of cell migration and PI3K/Akt/GSK3beta signalling pathway.	piperine	0-17	AKT serine/threonine kinase 1	Homo sapiens	203-206
31983100-0	2019	Piperine alkaloid induces anticancer and apoptotic effects in cisplatin resistant ovarian carcinoma by inducing G2/M phase cell cycle arrest, caspase activation and inhibition of cell migration and PI3K/Akt/GSK3beta signalling pathway.	piperine	0-17	glycogen synthase kinase 3 alpha	Homo sapiens	207-215
31983100-13	2019	Finally, Piperine also blocked the PI3K/Akt/GSK3beta signal transduction pathway in OVACAR-3 ovarian cancer cells.	piperine	9-17	AKT serine/threonine kinase 1	Homo sapiens	40-43
31983100-13	2019	Finally, Piperine also blocked the PI3K/Akt/GSK3beta signal transduction pathway in OVACAR-3 ovarian cancer cells.	piperine	9-17	glycogen synthase kinase 3 alpha	Homo sapiens	44-52
31425905-7	2019	Further, to understand the nature of interactions and the conformational flexibility of piperine in the active site of recombinant human acetylcholinesterase (rhAChE), molecular docking analysis has been performed.	piperine	88-96	acetylcholinesterase (Cartwright blood group)	Homo sapiens	137-157
31252023-0	2019	CDK2 and Bcl-xL inhibitory mechanisms by docking simulations and anti-tumor activity from piperine enriched supercritical extract.	piperine	90-98	cyclin-dependent kinase 2	Mus musculus	0-4
31252023-0	2019	CDK2 and Bcl-xL inhibitory mechanisms by docking simulations and anti-tumor activity from piperine enriched supercritical extract.	piperine	90-98	BCL2-like 1	Mus musculus	9-15
31252023-3	2019	In silico docking simulations predicted anti-tumor molecular mechanism and protein-piperine hydrophobic interactions, showing hydrogen bonds between piperine and residue Ser5 inside the ATP binding site in CDK2.	piperine	83-91	cyclin-dependent kinase 2	Mus musculus	206-210
31252023-3	2019	In silico docking simulations predicted anti-tumor molecular mechanism and protein-piperine hydrophobic interactions, showing hydrogen bonds between piperine and residue Ser5 inside the ATP binding site in CDK2.	piperine	149-157	cyclin-dependent kinase 2	Mus musculus	206-210
31252023-4	2019	Moreover, piperine interacts with peptide substrate residue Lys8 inside its binding site in Cyclin A molecule.	piperine	10-18	cyclin A2	Mus musculus	92-100
31252023-5	2019	Other predicted interaction showed piperine inside the hydrophobic groove of Bcl-xL.	piperine	35-43	BCL2-like 1	Mus musculus	77-83
31485676-0	2019	Piperine ameliorates the severity of fibrosis via inhibition of TGF-beta/SMAD signaling in a mouse model of chronic pancreatitis.	piperine	0-8	transforming growth factor, beta 1	Mus musculus	64-72
31485676-11	2019	In addition, piperine treatment reduced the expression of fibrotic mediators, such as alpha-smooth muscle actin (alpha-SMA), collagen, and fibronectin 1 in the pancreas and PSCs.	piperine	13-21	actin alpha 2, smooth muscle, aorta	Mus musculus	86-111
31485676-11	2019	In addition, piperine treatment reduced the expression of fibrotic mediators, such as alpha-smooth muscle actin (alpha-SMA), collagen, and fibronectin 1 in the pancreas and PSCs.	piperine	13-21	actin alpha 2, smooth muscle, aorta	Mus musculus	113-122
31485676-11	2019	In addition, piperine treatment reduced the expression of fibrotic mediators, such as alpha-smooth muscle actin (alpha-SMA), collagen, and fibronectin 1 in the pancreas and PSCs.	piperine	13-21	fibronectin 1	Mus musculus	139-152
31485676-12	2019	Moreover, piperine treatment reduced the production of transforming growth factor (TGF)-beta in the pancreas and PSCs.	piperine	10-18	transforming growth factor, beta 1	Mus musculus	83-92
31485676-13	2019	Furthermore, piperine treatment inhibited TGF-beta-induced pSMAD2/3 activation but not pSMAD1/5 in the PSCs.	piperine	13-21	transforming growth factor, beta 1	Mus musculus	42-50
31485676-14	2019	These findings suggest that piperine treatment ameliorates pancreatic fibrosis by inhibiting TGF-beta/SMAD2/3 signaling during CP.	piperine	28-36	transforming growth factor, beta 1	Mus musculus	93-101
31485676-14	2019	These findings suggest that piperine treatment ameliorates pancreatic fibrosis by inhibiting TGF-beta/SMAD2/3 signaling during CP.	piperine	28-36	SMAD family member 2	Mus musculus	102-109
31539794-0	2019	Effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in broiler chickens.	piperine	10-18	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	79-86
31539794-2	2019	Naturally available phyto chemicals like piperine and quercetin as well as some floroquinolones are known to inhibit MDR1 and CYP3A37 activity and increases bioavailability of co-administered drugs.	piperine	41-49	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	126-133
31539794-3	2019	This study was carried out to investigate the effect of piperine and quercetin alone or in combination with marbofloxacin on CYP3A37 and MDR1 mRNA expression levels in liver and intestine of broiler chicken.	piperine	56-64	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	125-132
31539794-6	2019	After piperine and quercetin combined treatment with marbofloxacin, CYP3A37 mRNA expression levels were significantly down regulated by 20.57 (p = .034) and 25.95 (p = .003) folds; and MDR1 mRNA expression levels were also significantly down regulated by 11.33 (p = .012) and 33.59 (p = .006) folds in liver and duodenum, respectively.	piperine	6-14	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	68-75
31539794-7	2019	Down regulation of CYP3A37 and MDR1 mRNA in liver and duodenum indicate the combined pretreatment of piperine and quercetin may be useful for improving the pharmacokinetics of orally administered drugs which are substrates for CYP3A37 and MDR1.	piperine	101-109	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	19-26
31539794-7	2019	Down regulation of CYP3A37 and MDR1 mRNA in liver and duodenum indicate the combined pretreatment of piperine and quercetin may be useful for improving the pharmacokinetics of orally administered drugs which are substrates for CYP3A37 and MDR1.	piperine	101-109	cytochrome P450 family 3 subfamily A member 5	Gallus gallus	227-234
31762997-9	2019	Western blotting analysis reveals that piperine administration inhibits Bax, while enhancing Bcl-2 expression.	piperine	39-47	BCL2 associated X, apoptosis regulator	Rattus norvegicus	72-75
31762997-9	2019	Western blotting analysis reveals that piperine administration inhibits Bax, while enhancing Bcl-2 expression.	piperine	39-47	BCL2, apoptosis regulator	Rattus norvegicus	93-98
31368246-8	2019	Full scan MS followed by data-dependent MS2 (Full MS-ddMS2 ) mode was used to establish mass spectrometric fragmentation pathways of protonated piperine and its metabolites.	piperine	144-152	MS2	Homo sapiens	50-58
31264835-8	2019	Moreover, piperine was also found to be effective for improving the r(CGG)exp associated splicing defects and RAN translation in a FXTAS cell model system.	piperine	10-18	RAN, member RAS oncogene family	Homo sapiens	110-113
31359554-1	2019	Previously, we reported that piperine, one of the major pungent components in black pepper, attenuates adipogenesis by repressing PPARgamma activity in 3T3-L1 preadipocytes.	piperine	29-37	peroxisome proliferator activated receptor gamma	Homo sapiens	130-139
31507403-7	2019	Of the four compounds screened, only curcumin (-9.6 kcal/mol) and piperine (-10.5 kcal/mol) showed favorable binding affinities and interactions towards AChE and were hence selected.	piperine	66-74	acetylcholinesterase (Cartwright blood group)	Homo sapiens	153-157
31507403-8	2019	In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml.	piperine	71-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	9-13
31507403-8	2019	In vitro AChE inhibition demonstrated that combination of curcumin and piperine showed greater AChE inhibition with an IC50 of 62.81 +- 0.01 mug/ml as compared to individual compounds, i.e., IC50 of curcumin at 134.5 +- 0.06 mug/ml and IC50 of piperine at 76.6 +- 0.08 mug/ml.	piperine	71-79	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
31392057-0	2019	A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study.	piperine	34-42	interleukin 10	Homo sapiens	89-94
31213294-0	2019	A distinct structural mechanism underlies TRPV1 activation by piperine.	piperine	62-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
31213294-1	2019	Piperine, the principle pungent compound in black peppers, is known to activate the capsaicin receptor TRPV1 ion channel.	piperine	0-8	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
31213294-8	2019	These findings help to explain why piperine is a weak agonist, and may guide future efforts to develop novel pharmaceutical reagents targeting TRPV1.	piperine	35-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-148
30498979-10	2019	RESULTS: Curcumin and piperine increased the TGF-beta level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-kB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair.	piperine	22-30	transforming growth factor alpha	Rattus norvegicus	45-53
30498979-10	2019	RESULTS: Curcumin and piperine increased the TGF-beta level, significantly improved the collagen repair, and decreased the cellularity and activation of NF-kB in the periodontal tissues, but only curcumin caused a significant increase in early bone repair.	piperine	22-30	RELA proto-oncogene, NF-kB subunit	Rattus norvegicus	153-158
31392057-0	2019	A combined treatment of curcumin, piperine, and taurine alters the circulating levels of IL-10 and miR-21 in hepatocellular carcinoma patients: a pilot study.	piperine	34-42	microRNA 21	Homo sapiens	99-105
31392057-3	2019	Thus, this study was designed to assess the effect of a combined treatment consisted of curcumin, piperine, and taurine on circulating levels of interleukin-10 (IL-10), and microRNAs miR-141 and miR-21.	piperine	98-106	interleukin 10	Homo sapiens	145-159
31392057-3	2019	Thus, this study was designed to assess the effect of a combined treatment consisted of curcumin, piperine, and taurine on circulating levels of interleukin-10 (IL-10), and microRNAs miR-141 and miR-21.	piperine	98-106	interleukin 10	Homo sapiens	161-166
31212743-0	2019	Experimental Approaches and Computational Modeling of Rat Serum Albumin and Its Interaction with Piperine.	piperine	97-105	albumin	Rattus norvegicus	58-71
31201588-7	2019	Meanwhile, piperine might have compromised the P-gp efflux mechanism, which can be ascribed to the enhanced retention of the drug at the target site.	piperine	11-19	phosphoglycolate phosphatase	Homo sapiens	47-51
31366578-8	2019	Injection of KEEC KW-2449 or piperine in Mecp2 mutant mice ameliorated disease-associated respiratory and locomotion phenotypes.	piperine	29-37	methyl CpG binding protein 2	Mus musculus	41-46
31365997-10	2019	Results: TGF-beta increased HUVECs proliferation (P&lt;0.05), which could be significantly inhibited by 10 and 20 mumol/L of piperine, but not by 1 and 5 mumol/L of piperine.	piperine	125-133	transforming growth factor beta 1	Homo sapiens	9-17
31365997-11	2019	Immunofluorescence results demonstrated that TGF-beta increased HUVECs transformation to fibroblasts as shown by downregulated expression of endothelial markers CD31, VE-cadherin, and upregulated expression of alpha-SMA and vimentin, again, these effects could be attenuated by 10 and 20 mumol/L piperine.	piperine	296-304	transforming growth factor beta 1	Homo sapiens	45-53
31365997-13	2019	The protein expression levels of snail and twist were significantly higher in TGF-beta group than in control group (both P&lt;0.05), which was significantly lower in TGF-beta+20 mumol/L piperine group than in TGF-beta group (both P&lt;0.05).	piperine	186-194	transforming growth factor beta 1	Homo sapiens	78-86
31365997-13	2019	The protein expression levels of snail and twist were significantly higher in TGF-beta group than in control group (both P&lt;0.05), which was significantly lower in TGF-beta+20 mumol/L piperine group than in TGF-beta group (both P&lt;0.05).	piperine	186-194	transforming growth factor beta 1	Homo sapiens	166-174
31365997-13	2019	The protein expression levels of snail and twist were significantly higher in TGF-beta group than in control group (both P&lt;0.05), which was significantly lower in TGF-beta+20 mumol/L piperine group than in TGF-beta group (both P&lt;0.05).	piperine	186-194	transforming growth factor beta 1	Homo sapiens	166-174
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	piperine	35-43	catenin beta 1	Homo sapiens	135-147
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	piperine	35-43	cyclin D1	Homo sapiens	149-157
30935902-6	2019	The inhibitory effect of curcumin, piperine and vitamin E on cell proliferation involves different markers, and in particular inhibits beta-catenin, cyclinD1 and p53, making them candidates for a possible use in alternative therapies although further studies are needed.	piperine	35-43	tumor protein p53	Homo sapiens	162-165
30611786-6	2019	Moreover, the effect of piperine on the xenobiotic receptor constitutive androstane receptor (CAR) was further accessed.	piperine	24-32	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	94-97
31033966-8	2019	The glutamate release-inhibiting effect of piperine was discovered to be prevented by the 5-HT1A receptor antagonist WAY100635 and the G protein betagamma subunit inhibitor gallein; however, it was unaffected by the adenylate cyclase inhibitor SQ22536 or the protein kinase A inhibitor PKI622.	piperine	43-51	5-hydroxytryptamine receptor 1A	Rattus norvegicus	90-96
31033966-9	2019	These results suggest that piperine inhibits glutamate release from rat hippocampal nerve terminals by reducing Ca2+ influx through N- and P/Q-type Ca2+ channels and that the activation of presynaptic 5-HT1A receptors and the G protein betagamma subunit is involved in this effect.	piperine	27-35	5-hydroxytryptamine receptor 1A	Rattus norvegicus	201-207
30952729-6	2019	Piperine increased the expression of BCL2-associated X, apoptosis regulator (BAX), cleaved poly(ADP-ribose)polymerase, cleaved caspase-9, phospho-c-Jun N-terminal kinase and phospho-p38, and reduced that of B-cell lymphoma 2 (BCL2), X-chromosome-linked inhibitor of apoptosis, and phospho-extracellular signal-regulated protein kinase (ERK1/2) in a concentration-dependent manner.	piperine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	37-81
30952729-6	2019	Piperine increased the expression of BCL2-associated X, apoptosis regulator (BAX), cleaved poly(ADP-ribose)polymerase, cleaved caspase-9, phospho-c-Jun N-terminal kinase and phospho-p38, and reduced that of B-cell lymphoma 2 (BCL2), X-chromosome-linked inhibitor of apoptosis, and phospho-extracellular signal-regulated protein kinase (ERK1/2) in a concentration-dependent manner.	piperine	0-8	caspase 9	Homo sapiens	127-136
30952729-6	2019	Piperine increased the expression of BCL2-associated X, apoptosis regulator (BAX), cleaved poly(ADP-ribose)polymerase, cleaved caspase-9, phospho-c-Jun N-terminal kinase and phospho-p38, and reduced that of B-cell lymphoma 2 (BCL2), X-chromosome-linked inhibitor of apoptosis, and phospho-extracellular signal-regulated protein kinase (ERK1/2) in a concentration-dependent manner.	piperine	0-8	BCL2 apoptosis regulator	Homo sapiens	207-224
30952729-6	2019	Piperine increased the expression of BCL2-associated X, apoptosis regulator (BAX), cleaved poly(ADP-ribose)polymerase, cleaved caspase-9, phospho-c-Jun N-terminal kinase and phospho-p38, and reduced that of B-cell lymphoma 2 (BCL2), X-chromosome-linked inhibitor of apoptosis, and phospho-extracellular signal-regulated protein kinase (ERK1/2) in a concentration-dependent manner.	piperine	0-8	BCL2 apoptosis regulator	Homo sapiens	37-41
30952729-6	2019	Piperine increased the expression of BCL2-associated X, apoptosis regulator (BAX), cleaved poly(ADP-ribose)polymerase, cleaved caspase-9, phospho-c-Jun N-terminal kinase and phospho-p38, and reduced that of B-cell lymphoma 2 (BCL2), X-chromosome-linked inhibitor of apoptosis, and phospho-extracellular signal-regulated protein kinase (ERK1/2) in a concentration-dependent manner.	piperine	0-8	mitogen-activated protein kinase 3	Homo sapiens	336-342
30952729-8	2019	Piperine increased the expression of apoptotic cells and cleaved-caspase-3 protein and reduced the expression of phospho-ERK1/2 protein in melanoma tumors.	piperine	0-8	mitogen-activated protein kinase 3	Homo sapiens	121-127
31217779-0	2019	Induction of apoptosis by piperine in human cervical adenocarcinoma via ROS mediated mitochondrial pathway and caspase-3 activation.	piperine	26-34	caspase 3	Homo sapiens	111-120
31217779-8	2019	In addition, piperine also encourages cell death by the loss of MMP, DNA fragmentation and the activation of caspase-3.	piperine	13-21	caspase 3	Homo sapiens	109-118
30343451-6	2019	Not only has piperine been evidenced to exhibit repressive effects on the maturation of dentritic cells, the proliferation, activation and function of T lymphocytes as well as the NF-kappaB signaling pathway, but also to suppress the overproduction of COX-2 and weaken the oxidative stress.	piperine	13-21	prostaglandin-endoperoxide synthase 2	Homo sapiens	252-257
30362574-3	2019	This was conducted both in the presence and absence of piperine as P-gp inhibitor.	piperine	55-63	ATP-dependent translocase ABCB1	Oryctolagus cuniculus	67-71
30579855-8	2019	Interestingly, piperine administration downregulated a number of critical factors in the complement and coagulation cascades, including complement component 3, fibrinogen gamma chain, alpha-2-macroglobulin, and serpin family A member 1.	piperine	15-23	complement C3	Rattus norvegicus	136-158
30579855-8	2019	Interestingly, piperine administration downregulated a number of critical factors in the complement and coagulation cascades, including complement component 3, fibrinogen gamma chain, alpha-2-macroglobulin, and serpin family A member 1.	piperine	15-23	fibrinogen gamma chain	Rattus norvegicus	160-182
30579855-8	2019	Interestingly, piperine administration downregulated a number of critical factors in the complement and coagulation cascades, including complement component 3, fibrinogen gamma chain, alpha-2-macroglobulin, and serpin family A member 1.	piperine	15-23	alpha-2-macroglobulin	Rattus norvegicus	184-205
30668388-0	2019	Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2.	piperine	0-8	BCR pseudogene 1	Homo sapiens	87-91
30668388-0	2019	Piperine enhances the bioavailability of silybin via inhibition of efflux transporters BCRP and MRP2.	piperine	0-8	ATP binding cassette subfamily C member 2	Rattus norvegicus	96-100
30668388-9	2019	The underlying mechanisms involved that piperine enhanced the absorption of silybin by inhibiting the efflux transporters including MRP2 and BCRP but not MDR1 in Caco-2 and transfected MDCKII cell lines.	piperine	40-48	ATP binding cassette subfamily C member 2	Homo sapiens	132-136
30668388-9	2019	The underlying mechanisms involved that piperine enhanced the absorption of silybin by inhibiting the efflux transporters including MRP2 and BCRP but not MDR1 in Caco-2 and transfected MDCKII cell lines.	piperine	40-48	BCR pseudogene 1	Homo sapiens	141-145
30611786-9	2019	Significant inhibition on rat liver microsomal activity, Cyp3a2 mRNA and protein expression, CAR mRNA were demonstrated with piperine at 35 mg/kg.	piperine	125-133	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	93-96
29714135-6	2019	RESULTS: In-vitro and in-vivo evidence supports the effect of berberine, trigonelline, piperine, oxymatrine, vindoneline, evodiamine and neferine on insulin-signaling and related cascades in beta-cells, myocytes, adipocytes, hepatocytes and other cells.	piperine	87-95	insulin	Homo sapiens	149-156
30439377-0	2018	Induction of functional erythropoietin and erythropoietin receptor gene expression by gamma-aminobutyric acid and piperine in kidney epithelial cells.	piperine	114-122	erythropoietin	Homo sapiens	24-38
30439377-0	2018	Induction of functional erythropoietin and erythropoietin receptor gene expression by gamma-aminobutyric acid and piperine in kidney epithelial cells.	piperine	114-122	erythropoietin	Homo sapiens	43-57
30439377-9	2018	SB203580 and SP600125 (p38 and JNK pathway inhibitors, respectively) attenuated GABA plus piperine-induced EPO and EPO-R expression.	piperine	90-98	mitogen-activated protein kinase 14	Homo sapiens	23-26
30439377-1	2018	AIMS: The aim of this study was to evaluate gamma-aminobutyric acid (GABA)- and piperine-induced erythropoietin (EPO) and EPO-receptor expression.	piperine	80-88	erythropoietin	Homo sapiens	97-111
30439377-9	2018	SB203580 and SP600125 (p38 and JNK pathway inhibitors, respectively) attenuated GABA plus piperine-induced EPO and EPO-R expression.	piperine	90-98	mitogen-activated protein kinase 8	Homo sapiens	31-34
30439377-1	2018	AIMS: The aim of this study was to evaluate gamma-aminobutyric acid (GABA)- and piperine-induced erythropoietin (EPO) and EPO-receptor expression.	piperine	80-88	erythropoietin	Homo sapiens	113-116
30439377-9	2018	SB203580 and SP600125 (p38 and JNK pathway inhibitors, respectively) attenuated GABA plus piperine-induced EPO and EPO-R expression.	piperine	90-98	erythropoietin	Homo sapiens	107-110
30439377-1	2018	AIMS: The aim of this study was to evaluate gamma-aminobutyric acid (GABA)- and piperine-induced erythropoietin (EPO) and EPO-receptor expression.	piperine	80-88	erythropoietin	Homo sapiens	122-125
30439377-3	2018	Expression levels of EPO and EPO-R mRNA and protein were evaluated in response to GABA and piperine treatments.	piperine	91-99	erythropoietin	Homo sapiens	21-24
30439377-9	2018	SB203580 and SP600125 (p38 and JNK pathway inhibitors, respectively) attenuated GABA plus piperine-induced EPO and EPO-R expression.	piperine	90-98	erythropoietin receptor	Homo sapiens	115-120
30439377-12	2018	SIGNIFICANCE: These findings demonstrate that GABA plus piperine-mediated p38 and JNK MAPK activation increases EPO and EPO-R expression, resulting in up-regulation of IL-10 and NF-kappaB.	piperine	56-64	mitogen-activated protein kinase 14	Homo sapiens	74-77
30439377-12	2018	SIGNIFICANCE: These findings demonstrate that GABA plus piperine-mediated p38 and JNK MAPK activation increases EPO and EPO-R expression, resulting in up-regulation of IL-10 and NF-kappaB.	piperine	56-64	mitogen-activated protein kinase 8	Homo sapiens	82-85
30439377-12	2018	SIGNIFICANCE: These findings demonstrate that GABA plus piperine-mediated p38 and JNK MAPK activation increases EPO and EPO-R expression, resulting in up-regulation of IL-10 and NF-kappaB.	piperine	56-64	mitogen-activated protein kinase 1	Homo sapiens	86-90
30439377-12	2018	SIGNIFICANCE: These findings demonstrate that GABA plus piperine-mediated p38 and JNK MAPK activation increases EPO and EPO-R expression, resulting in up-regulation of IL-10 and NF-kappaB.	piperine	56-64	erythropoietin	Homo sapiens	112-115
30439377-12	2018	SIGNIFICANCE: These findings demonstrate that GABA plus piperine-mediated p38 and JNK MAPK activation increases EPO and EPO-R expression, resulting in up-regulation of IL-10 and NF-kappaB.	piperine	56-64	erythropoietin receptor	Homo sapiens	120-125
30439377-12	2018	SIGNIFICANCE: These findings demonstrate that GABA plus piperine-mediated p38 and JNK MAPK activation increases EPO and EPO-R expression, resulting in up-regulation of IL-10 and NF-kappaB.	piperine	56-64	interleukin 10	Homo sapiens	168-173
30439377-3	2018	Expression levels of EPO and EPO-R mRNA and protein were evaluated in response to GABA and piperine treatments.	piperine	91-99	erythropoietin receptor	Homo sapiens	29-34
30439377-4	2018	GABA- and piperine-mediated activation of the mitogen-activated protein kinase (MAPK) signaling pathway was investigated.	piperine	10-18	mitogen-activated protein kinase 1	Homo sapiens	80-84
30439377-7	2018	KEY FINDINGS: Messenger RNA and protein expression levels of EPO and EPO-R significantly increased in response to treatment with GABA, piperine, or the combination of both, compared with control.	piperine	135-143	erythropoietin	Homo sapiens	61-64
30439377-7	2018	KEY FINDINGS: Messenger RNA and protein expression levels of EPO and EPO-R significantly increased in response to treatment with GABA, piperine, or the combination of both, compared with control.	piperine	135-143	erythropoietin receptor	Homo sapiens	69-74
30439377-8	2018	GABA plus piperine synergistically enhanced EPO and EPO-R expression through p38 and c-Jun N-terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal-regulated kinase (ERK) MAPK pathway.	piperine	10-18	erythropoietin	Homo sapiens	44-47
30439377-8	2018	GABA plus piperine synergistically enhanced EPO and EPO-R expression through p38 and c-Jun N-terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal-regulated kinase (ERK) MAPK pathway.	piperine	10-18	erythropoietin receptor	Homo sapiens	52-57
30439377-8	2018	GABA plus piperine synergistically enhanced EPO and EPO-R expression through p38 and c-Jun N-terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal-regulated kinase (ERK) MAPK pathway.	piperine	10-18	mitogen-activated protein kinase 14	Homo sapiens	77-80
30439377-8	2018	GABA plus piperine synergistically enhanced EPO and EPO-R expression through p38 and c-Jun N-terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal-regulated kinase (ERK) MAPK pathway.	piperine	10-18	mitogen-activated protein kinase 8	Homo sapiens	85-108
30439377-8	2018	GABA plus piperine synergistically enhanced EPO and EPO-R expression through p38 and c-Jun N-terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal-regulated kinase (ERK) MAPK pathway.	piperine	10-18	mitogen-activated protein kinase 8	Homo sapiens	110-113
30439377-8	2018	GABA plus piperine synergistically enhanced EPO and EPO-R expression through p38 and c-Jun N-terminal kinase (JNK) MAPK signaling pathways, but not through the extracellular signal-regulated kinase (ERK) MAPK pathway.	piperine	10-18	mitogen-activated protein kinase 1	Homo sapiens	115-119
29710511-0	2018	Piperine alleviates lipopolysaccharide-induced inflammatory injury by down-regulating microRNA-127 in murine chondrogenic ATDC5 cells.	piperine	0-8	microRNA 127	Mus musculus	86-98
29959624-0	2018	Combination Therapy with Curcumin Alone Plus Piperine Ameliorates Ovalbumin-Induced Chronic Asthma in Mice.	piperine	45-53	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	66-75
30388519-0	2018	Piperine ameliorated lupus nephritis by targeting AMPK-mediated activation of NLRP3 inflammasome.	piperine	0-8	NLR family, pyrin domain containing 3	Mus musculus	78-83
30388519-3	2018	Here we assessed the therapeutic potential of piperine, a bioactive compound known to target NLRP3 inflammasome, on LN development both in vivo and in vitro.	piperine	46-54	NLR family, pyrin domain containing 3	Mus musculus	93-98
30388519-5	2018	Upon treatment with increasing doses of piperine, we assessed renal lesions, measured serum levels of pro-inflammatory cytokines, and examined expressions of key components of NLRP3 inflammasome in kidney.	piperine	40-48	NLR family, pyrin domain containing 3	Mus musculus	176-181
30388519-8	2018	RESULTS: In pristane-injected mice, piperine significantly ameliorated LN development in a dose-dependent manner, which was associated with the inhibition of NLRP3 inflammasome and the reduction of serum IL-1beta, but not of IL-18 level.	piperine	36-44	NLR family, pyrin domain containing 3	Mus musculus	158-163
30388519-8	2018	RESULTS: In pristane-injected mice, piperine significantly ameliorated LN development in a dose-dependent manner, which was associated with the inhibition of NLRP3 inflammasome and the reduction of serum IL-1beta, but not of IL-18 level.	piperine	36-44	interleukin 1 beta	Mus musculus	204-212
30388519-8	2018	RESULTS: In pristane-injected mice, piperine significantly ameliorated LN development in a dose-dependent manner, which was associated with the inhibition of NLRP3 inflammasome and the reduction of serum IL-1beta, but not of IL-18 level.	piperine	36-44	interleukin 18	Mus musculus	225-230
30388519-9	2018	In HK-2 cells, piperine potently inhibited pyroptosis and the activation of NLRP3 inflammasome in response to LPS + ATP.	piperine	15-23	NLR family, pyrin domain containing 3	Mus musculus	76-81
30388519-11	2018	CONCLUSIONS: By targeting AMPK, piperine significantly suppressed the activation of NLRP3 inflammasome, inhibited the release of pro-inflammatory cytokines, blocked the pyroptosis of tubular epithelial cells, and thus suppressed the development of LN.	piperine	32-40	NLR family, pyrin domain containing 3	Mus musculus	84-89
30200386-0	2018	Th1-Biased Immunomodulation and In Vivo Antitumor Effect of a Novel Piperine Analogue.	piperine	68-76	negative elongation factor complex member C/D, Th1l	Mus musculus	0-3
30200386-13	2018	Our data provide evidence that the piperine analogue HE-02 present low toxicity, and its antitumor effect involves modulation of immune system to a cytotoxic Th1 profile.	piperine	35-43	negative elongation factor complex member C/D, Th1l	Mus musculus	158-161
29710511-5	2018	Piperine reduced the expression of miR-127 in ATDC5 cells.	piperine	0-8	microRNA 127	Mus musculus	35-42
29710511-11	2018	The anti-inflammatory properties of piperine are mediated by down-regulating miR-127 and MyD88 expression and then inhibiting NF-kappaB and p38MAPK signaling pathways activation.	piperine	36-44	microRNA 127	Mus musculus	77-84
29710511-11	2018	The anti-inflammatory properties of piperine are mediated by down-regulating miR-127 and MyD88 expression and then inhibiting NF-kappaB and p38MAPK signaling pathways activation.	piperine	36-44	myeloid differentiation primary response gene 88	Mus musculus	89-94
29710511-11	2018	The anti-inflammatory properties of piperine are mediated by down-regulating miR-127 and MyD88 expression and then inhibiting NF-kappaB and p38MAPK signaling pathways activation.	piperine	36-44	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	126-135
29710511-11	2018	The anti-inflammatory properties of piperine are mediated by down-regulating miR-127 and MyD88 expression and then inhibiting NF-kappaB and p38MAPK signaling pathways activation.	piperine	36-44	mitogen-activated protein kinase 14	Mus musculus	140-147
29800814-4	2018	The objective of the study was to determine whether curcumin and piperine have individual and combined effects in the setting of gut inflammation by regulating mTORC1 in human intestinal epithelial cells.	piperine	65-73	CREB regulated transcription coactivator 1	Mus musculus	160-166
29800814-6	2018	Piperine inhibited mTORC1 activity albeit at comparatively higher concentrations than curcumin.	piperine	0-8	CREB regulated transcription coactivator 1	Mus musculus	19-25
29800814-0	2018	Piperine potentiates curcumin-mediated repression of mTORC1 signaling in human intestinal epithelial cells: implications for the inhibition of protein synthesis and TNFalpha signaling.	piperine	0-8	CREB regulated transcription coactivator 1	Mus musculus	53-59
29800814-7	2018	The combination of curcumin + piperine further repressed mTORC1 signaling (P&lt;.02).	piperine	30-38	CREB regulated transcription coactivator 1	Mus musculus	57-63
29800814-10	2018	Curcumin, piperine and their combination inhibited TNFalpha gene expression at baseline but failed to do so under conditions of mTORC1 hyperactivation.	piperine	10-18	tumor necrosis factor	Homo sapiens	51-59
29800814-11	2018	TNF -induced cyclooxygenase-2 expression was repressed by curcumin or curcumin + piperine at baseline and high mTORC1 levels.	piperine	81-89	tumor necrosis factor	Homo sapiens	0-3
29800814-11	2018	TNF -induced cyclooxygenase-2 expression was repressed by curcumin or curcumin + piperine at baseline and high mTORC1 levels.	piperine	81-89	prostaglandin-endoperoxide synthase 2	Homo sapiens	13-29
29800814-12	2018	We conclude that curcumin and piperine, either alone or in combination, have the potential to down-regulate mTORC1 signaling in the intestinal epithelium with implications for tumorigenesis and inflammation.	piperine	30-38	CREB regulated transcription coactivator 1	Mus musculus	108-114
29683271-0	2018	Piperine Promotes Glucose Uptake through ROS-Dependent Activation of the CAMKK/AMPK Signaling Pathway in Skeletal Muscle.	piperine	0-8	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	73-78
30058545-8	2018	Similarly proinflammatory marker COX-2 expression was significantly inhibited in the presence of piperine when compared to untreated controls.	piperine	97-105	cytochrome c oxidase II, mitochondrial	Mus musculus	33-38
30058545-10	2018	Taken together, the capabilities of piperine to induce an apoptosis by decreasing the neurite outgrowth, proliferation rate and expression of TN-C and COX-2 in Neuro-2a cell line confirmed for its anticancerous and anti-inflammatory potential.	piperine	36-44	tenascin C	Mus musculus	142-146
30058545-10	2018	Taken together, the capabilities of piperine to induce an apoptosis by decreasing the neurite outgrowth, proliferation rate and expression of TN-C and COX-2 in Neuro-2a cell line confirmed for its anticancerous and anti-inflammatory potential.	piperine	36-44	cytochrome c oxidase II, mitochondrial	Mus musculus	151-156
29683271-7	2018	Treatment of myotubes with piperine induces the translocation of glucose transporter 4 (GLUT4) to the plasma membrane by phosphorylation of AMP-activated protein kinase (AMPK).	piperine	27-35	solute carrier family 2 member 4	Homo sapiens	65-86
29683271-7	2018	Treatment of myotubes with piperine induces the translocation of glucose transporter 4 (GLUT4) to the plasma membrane by phosphorylation of AMP-activated protein kinase (AMPK).	piperine	27-35	solute carrier family 2 member 4	Homo sapiens	88-93
29683271-8	2018	Piperine increases the intracellular Ca2+ level and reactive oxygen species (ROS) generation through transient receptor potential vanilloid channel 1 (TRPV1), followed by activation of Ca2+ /calmodulin-dependent protein kinase kinase-beta (CaMKKbeta) as the upstream events for AMPK phosphorylation.	piperine	0-8	transient receptor potential cation channel subfamily V member 1	Homo sapiens	101-149
29683271-8	2018	Piperine increases the intracellular Ca2+ level and reactive oxygen species (ROS) generation through transient receptor potential vanilloid channel 1 (TRPV1), followed by activation of Ca2+ /calmodulin-dependent protein kinase kinase-beta (CaMKKbeta) as the upstream events for AMPK phosphorylation.	piperine	0-8	transient receptor potential cation channel subfamily V member 1	Homo sapiens	151-156
29683271-8	2018	Piperine increases the intracellular Ca2+ level and reactive oxygen species (ROS) generation through transient receptor potential vanilloid channel 1 (TRPV1), followed by activation of Ca2+ /calmodulin-dependent protein kinase kinase-beta (CaMKKbeta) as the upstream events for AMPK phosphorylation.	piperine	0-8	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	240-249
29683271-9	2018	Furthermore, oral administration of piperine to Wistar rats at 0.01 and 0.1 mg kg-1 body weight decreases postprandial hyperglycemia accompanied by GLUT4 translocation and AMPK phosphorylation.	piperine	36-44	solute carrier family 2 member 4	Rattus norvegicus	148-153
29683271-10	2018	CONCLUSION: Piperine in pepper prevents hyperglycemia by GLUT4 translocation through CaMKKbeta/AMPK signaling via TRPV1-dependent increase in the intracellular Ca2+ level and ROS generation.	piperine	12-20	solute carrier family 2 member 4	Homo sapiens	57-62
29683271-10	2018	CONCLUSION: Piperine in pepper prevents hyperglycemia by GLUT4 translocation through CaMKKbeta/AMPK signaling via TRPV1-dependent increase in the intracellular Ca2+ level and ROS generation.	piperine	12-20	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	85-94
29683271-10	2018	CONCLUSION: Piperine in pepper prevents hyperglycemia by GLUT4 translocation through CaMKKbeta/AMPK signaling via TRPV1-dependent increase in the intracellular Ca2+ level and ROS generation.	piperine	12-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	114-119
29717031-7	2018	These results provide the first evidence for the anticancer potential of Piperine in ovarian cancer cells, partially via JNK/p38 MAPK-mediated intrinsic apoptotic pathway.	piperine	73-81	mitogen-activated protein kinase 14	Homo sapiens	125-128
29488612-0	2018	Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells.	piperine	0-8	AKT serine/threonine kinase 1	Homo sapiens	68-71
29717031-0	2018	Piperine functions as a tumor suppressor for human ovarian tumor growth via activation of JNK/p38 MAPK-mediated intrinsic apoptotic pathway.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	94-97
29717031-4	2018	Flow cytometric analysis revealed that Piperine suppressed cells proliferation via induction of apoptosis, which was followed by release of mitochondrial cytochrome c to cytosol, activation of caspase-3 and -9, as well as cleaved PARP.	piperine	39-47	cytochrome c, somatic	Homo sapiens	154-166
29717031-4	2018	Flow cytometric analysis revealed that Piperine suppressed cells proliferation via induction of apoptosis, which was followed by release of mitochondrial cytochrome c to cytosol, activation of caspase-3 and -9, as well as cleaved PARP.	piperine	39-47	caspase 3	Homo sapiens	193-209
29717031-4	2018	Flow cytometric analysis revealed that Piperine suppressed cells proliferation via induction of apoptosis, which was followed by release of mitochondrial cytochrome c to cytosol, activation of caspase-3 and -9, as well as cleaved PARP.	piperine	39-47	poly(ADP-ribose) polymerase 1	Homo sapiens	230-234
29717031-5	2018	Moreover, Western blot results confirmed that Piperine (8, 16, and 20 muM) decreased phosphorylation of JNK and p38 MAPK in A2780 cells.	piperine	46-54	latexin	Homo sapiens	70-73
29717031-5	2018	Moreover, Western blot results confirmed that Piperine (8, 16, and 20 muM) decreased phosphorylation of JNK and p38 MAPK in A2780 cells.	piperine	46-54	mitogen-activated protein kinase 14	Homo sapiens	112-115
29359345-5	2018	Competitive binding assay showed piperine, praeruptorin A, and schizandrin A acting on MrgprX2 and cinobufagin and osthole act on the IgE receptor.	piperine	33-41	MAS related GPR family member X2	Rattus norvegicus	87-94
29488612-0	2018	Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells.	piperine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	72-76
29488612-0	2018	Piperine depresses the migration progression via downregulating the Akt/mTOR/MMP-9 signaling pathway in DU145 cells.	piperine	0-8	matrix metallopeptidase 9	Homo sapiens	77-82
29488612-8	2018	Furthermore, piperine reduced the expression of p-Akt, MMP-9 and p-mTOR.	piperine	13-21	AKT serine/threonine kinase 1	Homo sapiens	50-53
29488612-8	2018	Furthermore, piperine reduced the expression of p-Akt, MMP-9 and p-mTOR.	piperine	13-21	matrix metallopeptidase 9	Homo sapiens	55-60
29488612-8	2018	Furthermore, piperine reduced the expression of p-Akt, MMP-9 and p-mTOR.	piperine	13-21	mechanistic target of rapamycin kinase	Homo sapiens	67-71
29643806-9	2018	Consistent with increase in serum T, piperine increased Leydig cell number, cell size, and multiple steroidogenic pathway proteins, including steroidogenic acute regulatory protein, cholesterol side-chain cleavage enzyme, 3beta-hydroxysteroid dehydrogenase 1, 17alpha-hydroxylase/20-lyase, and steroidogenic factor 1 expression levels.	piperine	37-45	nuclear receptor subfamily 5, group A, member 1	Rattus norvegicus	260-316
29643806-10	2018	Piperine significantly increased the ratio of phospho-AKT1 (pAKT1)/AKT1, phosphos-AKT2 (pAKT2)/AKT2, and phospho-ERK1/2 (pERK1/2)/ERK1/2 in the testis.	piperine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	54-58
29643806-10	2018	Piperine significantly increased the ratio of phospho-AKT1 (pAKT1)/AKT1, phosphos-AKT2 (pAKT2)/AKT2, and phospho-ERK1/2 (pERK1/2)/ERK1/2 in the testis.	piperine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	61-65
29643806-10	2018	Piperine significantly increased the ratio of phospho-AKT1 (pAKT1)/AKT1, phosphos-AKT2 (pAKT2)/AKT2, and phospho-ERK1/2 (pERK1/2)/ERK1/2 in the testis.	piperine	0-8	AKT serine/threonine kinase 2	Rattus norvegicus	82-86
29643806-10	2018	Piperine significantly increased the ratio of phospho-AKT1 (pAKT1)/AKT1, phosphos-AKT2 (pAKT2)/AKT2, and phospho-ERK1/2 (pERK1/2)/ERK1/2 in the testis.	piperine	0-8	AKT serine/threonine kinase 2	Rattus norvegicus	89-93
29643806-10	2018	Piperine significantly increased the ratio of phospho-AKT1 (pAKT1)/AKT1, phosphos-AKT2 (pAKT2)/AKT2, and phospho-ERK1/2 (pERK1/2)/ERK1/2 in the testis.	piperine	0-8	mitogen activated protein kinase 3	Rattus norvegicus	113-119
29643806-10	2018	Piperine significantly increased the ratio of phospho-AKT1 (pAKT1)/AKT1, phosphos-AKT2 (pAKT2)/AKT2, and phospho-ERK1/2 (pERK1/2)/ERK1/2 in the testis.	piperine	0-8	mitogen activated protein kinase 3	Rattus norvegicus	122-128
29643806-14	2018	ERK1/2 and AKT pathways may involve in the piperine-mediated stimulation of Leydig cell development.	piperine	43-51	mitogen activated protein kinase 3	Rattus norvegicus	0-6
29643806-14	2018	ERK1/2 and AKT pathways may involve in the piperine-mediated stimulation of Leydig cell development.	piperine	43-51	AKT serine/threonine kinase 1	Rattus norvegicus	11-14
29445415-0	2018	Curcumin and piperine supplementation of obese mice under caloric restriction modulates body fat and interleukin-1beta.	piperine	13-21	interleukin 1 beta	Mus musculus	101-118
29497610-12	2018	Piperine is a potent inhibitor of p-glycoprotein (P-gp) and has a significant effect on the drug metabolizing enzyme (DME) system.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	34-48
29497610-12	2018	Piperine is a potent inhibitor of p-glycoprotein (P-gp) and has a significant effect on the drug metabolizing enzyme (DME) system.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	50-54
29497610-13	2018	Because of its inhibitory influence on P-gp activity, piperine can reverse multidrug resistance (MDR) in cancer cells and acts as bioavailability enhancer for many chemotherapeutic agents.	piperine	54-62	ATP binding cassette subfamily B member 1	Homo sapiens	39-43
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	piperine	71-79	ATP binding cassette subfamily B member 1	Homo sapiens	236-250
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	piperine	71-79	ATP binding cassette subfamily B member 1	Homo sapiens	252-256
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	piperine	71-79	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	268-271
29498663-6	2018	Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines.	piperine	27-35	ATP binding cassette subfamily B member 1	Homo sapiens	96-110
29498663-6	2018	Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines.	piperine	27-35	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
29498663-7	2018	CONCLUSION: Our study has demonstrated that capsaicin and piperine are P-gp substrates and have potential chemosensitizing activity, which might be interesting for the development of novel modulators of multidrug resistance.	piperine	58-66	ATP binding cassette subfamily B member 1	Homo sapiens	71-75
29414892-4	2018	This study aimed to test the hypothesis that phytochemical P-gp inhibitors, i.e., piperine, capsaicin and [6]-gingerol, modulate the in vivo tissue distribution of doxorubicin, a representative P-gp substrate.	piperine	82-90	phosphoglycolate phosphatase	Mus musculus	59-63
29414892-4	2018	This study aimed to test the hypothesis that phytochemical P-gp inhibitors, i.e., piperine, capsaicin and [6]-gingerol, modulate the in vivo tissue distribution of doxorubicin, a representative P-gp substrate.	piperine	82-90	phosphoglycolate phosphatase	Mus musculus	194-198
29445415-8	2018	Results: Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1beta and KC/GRO.	piperine	86-89	interleukin 1 beta	Mus musculus	146-154
29445415-8	2018	Results: Compared to the other groups, obese mice who underwent CR and received Cur + Pip in their diet lost more fat and had significantly lower IL-1beta and KC/GRO.	piperine	86-89	chemokine (C-X-C motif) ligand 1	Mus musculus	162-165
29133241-3	2018	In vitro studies on doxorubicin (DOX)-resistant NCI/ADR-RES cells, known to express P-gp, showed that, dose-dependently, PIP significantly increased intracellular accumulation of rhodamine-123 and had cytotoxic effects accessed by MTT assay.	piperine	121-124	ATP binding cassette subfamily B member 1	Homo sapiens	84-88
29455730-4	2018	The inhibitory effect of piperine on P-gp and CYP3A4 was determined using a Caco-2 monolayer model and a recombinant CYP3A4 metabolic system, respectively.	piperine	25-33	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	37-41
29378605-7	2018	Of these inducers, piperine is an agent that potently induces the luciferase expression or MANF expression.	piperine	19-27	mesencephalic astrocyte-derived neurotrophic factor	Mus musculus	91-95
29378605-8	2018	RESULTS: Addition of piperine in both cellular and mouse models of SCA17 alleviated toxicity caused by mutant TBP.	piperine	21-29	TATA box binding protein	Mus musculus	110-113
29378605-11	2018	CONCLUSION: Our study established piperine as a MANF-based therapeutic agent for ER stress-related neuropathology in SCA17.	piperine	34-42	mesencephalic astrocyte-derived neurotrophic factor	Mus musculus	48-52
29133241-8	2018	In conclusion, both in silico and in vitro studies confirm that PIP is an inhibitor of P-gp mediated DOX efflux, suggesting PIP as a promising adjuvant to DOX cancer chemotherapy.	piperine	124-127	ATP binding cassette subfamily B member 1	Homo sapiens	87-91
28799699-5	2018	TRPV1/A1 stimulation with piperine reduced penetrations by 56.32%, LVC time by 25.55% and increased bolus velocity by 23.63%.	piperine	26-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
29133241-5	2018	P-gp ATPase assay showed that both DOX and PIP had dose-dependent inhibition of orthovandate-sensitive ATPase activity, indicating they are both P-gp inhibitors, with IC50 of 84+-1 and 37+-2muM, respectively.	piperine	43-46	ATP binding cassette subfamily B member 1	Homo sapiens	0-4
29133241-5	2018	P-gp ATPase assay showed that both DOX and PIP had dose-dependent inhibition of orthovandate-sensitive ATPase activity, indicating they are both P-gp inhibitors, with IC50 of 84+-1 and 37+-2muM, respectively.	piperine	43-46	ATP binding cassette subfamily B member 1	Homo sapiens	145-149
29133241-7	2018	Using DOX at concentration 33.33muM together with PIP (100muM), DOX-mediated P-gp ATPase activity was decreased to levels 4-folds lower than DOX alone.	piperine	50-53	ATP binding cassette subfamily B member 1	Homo sapiens	77-81
29133241-8	2018	In conclusion, both in silico and in vitro studies confirm that PIP is an inhibitor of P-gp mediated DOX efflux, suggesting PIP as a promising adjuvant to DOX cancer chemotherapy.	piperine	64-67	ATP binding cassette subfamily B member 1	Homo sapiens	87-91
29203239-0	2018	Piperine induces osteoblast differentiation through AMPK-dependent Runx2 expression.	piperine	0-8	runt related transcription factor 2	Mus musculus	67-72
29203239-5	2018	Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated using RT-PCR.	piperine	0-8	distal-less homeobox 5	Mus musculus	60-82
29203239-5	2018	Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated using RT-PCR.	piperine	0-8	distal-less homeobox 5	Mus musculus	84-88
29203239-5	2018	Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated using RT-PCR.	piperine	0-8	inhibitor of DNA binding 1, HLH protein	Mus musculus	91-117
29203239-5	2018	Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated using RT-PCR.	piperine	0-8	inhibitor of DNA binding 1, HLH protein	Mus musculus	119-122
29203239-5	2018	Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated using RT-PCR.	piperine	0-8	runt related transcription factor 2	Mus musculus	129-164
29203239-5	2018	Piperine-induced expression of the osteogenic genes such as distal-less homeobox 5 (Dlx5), inhibitor of DNA binding-1 (Id1), and runt-related transcription factor 2 (Runx2) was investigated using RT-PCR.	piperine	0-8	runt related transcription factor 2	Mus musculus	166-171
28165813-7	2018	Administration of piperine improved the morphological structure of tendon, increased glycosaminoglycans and hydroxyproline levels, and inhibited the expression and activities of MMP-2 and MMP-9.	piperine	18-26	matrix metallopeptidase 2	Rattus norvegicus	178-183
28165813-7	2018	Administration of piperine improved the morphological structure of tendon, increased glycosaminoglycans and hydroxyproline levels, and inhibited the expression and activities of MMP-2 and MMP-9.	piperine	18-26	matrix metallopeptidase 9	Rattus norvegicus	188-193
28165813-8	2018	Furthermore, piperine inhibited the activation of ERK and p38 signaling pathways in injured tendon.	piperine	13-21	mitogen activated protein kinase 14	Rattus norvegicus	58-61
29227934-2	2018	Given that piperine is also an activator of TRPV1 (transient receptor potential vanilloid type 1) receptors involved in pain signaling and thermoregulation, a series of piperine analogs were prepared in several cycles of structural optimization, with the aim of separating GABAA and TRPV1 activating properties.	piperine	11-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-49
28545378-7	2018	Interestingly, piperine has exhibited antimutagenic activity and also inhibited activity and expression of multidrug resistance transporters such as P-gp and MRP-1.	piperine	15-23	phosphoglycolate phosphatase	Homo sapiens	149-153
28545378-7	2018	Interestingly, piperine has exhibited antimutagenic activity and also inhibited activity and expression of multidrug resistance transporters such as P-gp and MRP-1.	piperine	15-23	ATP binding cassette subfamily C member 1	Homo sapiens	158-163
29779481-8	2018	The effect of piperine on the transport of the compounds that were identified to be P-gp substrates was also assessed.	piperine	14-22	phosphoglycolate phosphatase	Homo sapiens	84-88
29227934-2	2018	Given that piperine is also an activator of TRPV1 (transient receptor potential vanilloid type 1) receptors involved in pain signaling and thermoregulation, a series of piperine analogs were prepared in several cycles of structural optimization, with the aim of separating GABAA and TRPV1 activating properties.	piperine	11-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-96
29227934-2	2018	Given that piperine is also an activator of TRPV1 (transient receptor potential vanilloid type 1) receptors involved in pain signaling and thermoregulation, a series of piperine analogs were prepared in several cycles of structural optimization, with the aim of separating GABAA and TRPV1 activating properties.	piperine	11-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	283-288
29227934-2	2018	Given that piperine is also an activator of TRPV1 (transient receptor potential vanilloid type 1) receptors involved in pain signaling and thermoregulation, a series of piperine analogs were prepared in several cycles of structural optimization, with the aim of separating GABAA and TRPV1 activating properties.	piperine	169-177	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-49
29227934-8	2018	Piperine was exclusively metabolized by CYP1A2, whereas CYP2C9 contributed significantly in the oxidative metabolism of all analogs.	piperine	0-8	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	40-46
28948673-6	2017	Piperine (1-1000 muM) increased the free fraction (fu) of both albumin and alpha-acid glycoprotein bound drugs in a concentration-dependent manner (p &lt; 0.01).	piperine	0-8	latexin	Homo sapiens	17-20
29063362-0	2018	Piperine-like alkamides from Piper nigrum induce BDNF promoter and promote neurite outgrowth in Neuro-2a cells.	piperine	0-8	brain derived neurotrophic factor	Mus musculus	49-53
29423050-2	2018	Piperine (PIP) could enhance the bioavailability of other drugs via the inhibition of CYPs and P-gp activities.	piperine	0-8	phosphoglycolate phosphatase	Mus musculus	95-99
29423050-2	2018	Piperine (PIP) could enhance the bioavailability of other drugs via the inhibition of CYPs and P-gp activities.	piperine	10-13	phosphoglycolate phosphatase	Mus musculus	95-99
29423050-10	2018	Further microarray analysis revealed that PIP inhibited P-gp as well as CYP1B1 gene expression and induced a significant gene expression change relating to inflammatory response, angiogenesis, cell proliferation, or cell migration.	piperine	42-45	phosphoglycolate phosphatase	Mus musculus	56-60
29423050-10	2018	Further microarray analysis revealed that PIP inhibited P-gp as well as CYP1B1 gene expression and induced a significant gene expression change relating to inflammatory response, angiogenesis, cell proliferation, or cell migration.	piperine	42-45	cytochrome P450, family 1, subfamily b, polypeptide 1	Mus musculus	72-78
29423050-12	2018	Such effect appeared to be attributed to the inhibitory effect of PIP on CYPs and P-gp activity as well as gene expression changes relating to tumorigenesis and cellular responses.	piperine	66-69	phosphoglycolate phosphatase	Mus musculus	82-86
29169726-0	2017	Piperine (PP) enhanced mitomycin-C (MMC) therapy of human cervical cancer through suppressing Bcl-2 signaling pathway via inactivating STAT3/NF-kappaB.	piperine	0-8	BCL2 apoptosis regulator	Homo sapiens	94-99
29169726-0	2017	Piperine (PP) enhanced mitomycin-C (MMC) therapy of human cervical cancer through suppressing Bcl-2 signaling pathway via inactivating STAT3/NF-kappaB.	piperine	0-8	signal transducer and activator of transcription 3	Homo sapiens	135-140
29169726-0	2017	Piperine (PP) enhanced mitomycin-C (MMC) therapy of human cervical cancer through suppressing Bcl-2 signaling pathway via inactivating STAT3/NF-kappaB.	piperine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	141-150
28948673-7	2017	Moreover, piperine (10 muM) increased the uptake of 3 H-propranolol and 14 C-warfarin by BMECs (p &lt; 0.01).	piperine	10-18	latexin	Homo sapiens	23-26
28736128-13	2017	The extra augmentation in the absorption of CBD and THC by incorporating piperine into PNL is attributed to the inhibition of Phase I and phase II metabolism by piperine in addition to the Phase I metabolism and P-gp inhibition by PNL.	piperine	73-81	phosphoglycolate phosphatase	Rattus norvegicus	212-216
27670974-0	2017	Effect of piperine on CYP2E1 enzyme activity of chlorzoxazone in healthy volunteers.	piperine	10-18	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	22-28
27670974-2	2017	The purpose of the present study was to investigate the effect of piperine (PIP) on CYP2E1 enzyme activity and pharmacokinetics of chlorzoxazone (CHZ) in healthy volunteers.	piperine	66-74	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	84-90
27670974-2	2017	The purpose of the present study was to investigate the effect of piperine (PIP) on CYP2E1 enzyme activity and pharmacokinetics of chlorzoxazone (CHZ) in healthy volunteers.	piperine	76-79	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	84-90
27670974-13	2017	The results suggest that altered pharmacokinetics of CHZ might be attributed to PIP mediated inhibition of CYP2E1 enzyme, which indicate significant pharmacokinetic interaction present between PIP and CHZ.	piperine	80-83	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	107-113
27670974-13	2017	The results suggest that altered pharmacokinetics of CHZ might be attributed to PIP mediated inhibition of CYP2E1 enzyme, which indicate significant pharmacokinetic interaction present between PIP and CHZ.	piperine	193-196	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	107-113
27670974-14	2017	The inhibition of CYP2E1 by PIP may represent a novel therapeutic benefit for minimizing ethanol induced CYP2E1 enzyme activity and results in reduced hepatotoxicity of ethanol.	piperine	28-31	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	18-24
27670974-14	2017	The inhibition of CYP2E1 by PIP may represent a novel therapeutic benefit for minimizing ethanol induced CYP2E1 enzyme activity and results in reduced hepatotoxicity of ethanol.	piperine	28-31	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	105-111
28801675-0	2017	Targeting P-glycoprotein: Investigation of piperine analogs for overcoming drug resistance in cancer.	piperine	43-51	ATP binding cassette subfamily B member 1	Homo sapiens	10-24
29142409-11	2017	Piperine induced hormonal imbalance by altering the serum levels of follicle-stimulating hormone, luteinizing hormone, sex hormone binding globulin, serum, and testicular testosterone in groups ED and E4D.	piperine	0-8	sex hormone binding globulin	Rattus norvegicus	119-147
28801675-4	2017	In this study, two structurally simple, low molecular weight piperine analogs Pip1 and Pip2 were designed and found to better interact with P-gp than piperine in silico.	piperine	61-69	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-82
28801675-4	2017	In this study, two structurally simple, low molecular weight piperine analogs Pip1 and Pip2 were designed and found to better interact with P-gp than piperine in silico.	piperine	61-69	ATP binding cassette subfamily B member 1	Homo sapiens	140-144
28801675-4	2017	In this study, two structurally simple, low molecular weight piperine analogs Pip1 and Pip2 were designed and found to better interact with P-gp than piperine in silico.	piperine	150-158	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	78-82
28801675-8	2017	These investigations suggest that the natural product analog - Pip1 ((2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1 H)-yl)penta-2,4-dien-1-one) - is superior to piperine and could inhibit P-gp function.	piperine	195-203	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	63-67
28801675-8	2017	These investigations suggest that the natural product analog - Pip1 ((2E,4E)-5-(benzo[d][1,3]dioxol-5-yl)-1-(6,7-dimethoxy-3,4-dihydroisoquinolin-2(1 H)-yl)penta-2,4-dien-1-one) - is superior to piperine and could inhibit P-gp function.	piperine	195-203	ATP binding cassette subfamily B member 1	Homo sapiens	222-226
28680454-0	2017	Piperine enhances carbohydrate/fat metabolism in skeletal muscle during acute exercise in mice.	piperine	0-8	CD36 molecule	Mus musculus	31-34
28680454-10	2017	CONCLUSION: Our findings demonstrate that piperine promoted beneficial metabolism during exercise by regulating carbohydrate/fat metabolism and redox signals.	piperine	42-50	CD36 molecule	Mus musculus	125-128
28341137-5	2017	Further molecular studies evidenced the prooxidant property of piperine by inducing H2O2 driven mitochondria-mediated apoptosis in Hep G2 cells by inhibiting the peroxide detoxifying enzyme Catalase.	piperine	63-71	catalase	Homo sapiens	190-198
28694780-12	2017	These compounds were evaluated on Xenopus laevis oocytes expressing the human orthologues of KCNK3, KNCK9 and KCNK18, which we previously showed to be inhibited by piperine.	piperine	164-172	potassium two pore domain channel subfamily K member 3	Homo sapiens	93-98
28550736-0	2017	Piperine attenuates UV-R induced cell damage in human keratinocytes via NF-kB, Bax/Bcl-2 pathway: An application for photoprotection.	piperine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
28550736-0	2017	Piperine attenuates UV-R induced cell damage in human keratinocytes via NF-kB, Bax/Bcl-2 pathway: An application for photoprotection.	piperine	0-8	BCL2 apoptosis regulator	Homo sapiens	83-88
28550736-10	2017	Molecular docking studies suggest that PIP binds at the active site of NF-kappaB, and thus, preventing its translocation to nucleus.	piperine	39-42	nuclear factor kappa B subunit 1	Homo sapiens	71-80
28550736-12	2017	However, PIP induced expression of IkB-alpha suppress the NF-kappaB activity which resulted in suppression of apoptotic marker genes and proteins that involved in photoprotection.	piperine	9-12	NFKB inhibitor alpha	Homo sapiens	35-44
28550736-12	2017	However, PIP induced expression of IkB-alpha suppress the NF-kappaB activity which resulted in suppression of apoptotic marker genes and proteins that involved in photoprotection.	piperine	9-12	nuclear factor kappa B subunit 1	Homo sapiens	58-67
28426244-8	2017	Moreover, piperine stimulated cell death by inducing loss of MMP, and caspase-3 activation.	piperine	10-18	caspase 3	Homo sapiens	70-79
28426244-10	2017	Findings of this study suggest the efficacy of piperine in inducing cell death via the decrease in MMP and ROS liberation followed by caspase-3 activation and cell cycle arrest.	piperine	47-55	caspase 3	Homo sapiens	134-143
28694780-12	2017	These compounds were evaluated on Xenopus laevis oocytes expressing the human orthologues of KCNK3, KNCK9 and KCNK18, which we previously showed to be inhibited by piperine.	piperine	164-172	potassium two pore domain channel subfamily K member 18	Homo sapiens	110-116
33429588-0	2017	Uniform, Polycrystalline, and Thermostable Piperine-Coated Gold Nanoparticles to Target Insulin Fibril Assembly.	piperine	43-51	insulin	Homo sapiens	88-95
33429588-3	2017	In this work, we have synthesized uniform sized, thermostable gold nanoparticles (AuNPspiperine) surface-functionalized with piperine to target amyloid-prone residues of insulin.	piperine	87-95	insulin	Homo sapiens	170-177
33429588-6	2017	Fluorescence quenching data revealed binding of AuNPspiperine with insulin"s native structure which was further validated by docking studies that predicted viable H-bond and CH-pi interactions between piperine and key aggregation-prone residues of insulin"s B-chain.	piperine	53-61	insulin	Homo sapiens	67-74
28330809-11	2017	In conclusion, piperine attenuated cardiac fibrosis via the activation of PPAR-gamma and the resultant inhibition of AKT/GSK3beta.	piperine	15-23	peroxisome proliferator activated receptor gamma	Mus musculus	74-84
33429588-6	2017	Fluorescence quenching data revealed binding of AuNPspiperine with insulin"s native structure which was further validated by docking studies that predicted viable H-bond and CH-pi interactions between piperine and key aggregation-prone residues of insulin"s B-chain.	piperine	53-61	insulin	Homo sapiens	248-255
33429588-8	2017	Data obtained from both experimental and computational studies suggest that the retention of native structure of insulin and the ability of the piperine molecule to interact with the aggregation-prone residues of insulin are the key factors for the inhibition mechanism.	piperine	144-152	insulin	Homo sapiens	213-220
28397086-9	2017	Pre-treatment of cells with piperine and its cyclohexylamino analog decreased the tunicamycin-induced upregulation of GRP78 and CHOP and cell death.	piperine	28-36	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	118-123
28397086-9	2017	Pre-treatment of cells with piperine and its cyclohexylamino analog decreased the tunicamycin-induced upregulation of GRP78 and CHOP and cell death.	piperine	28-36	DNA-damage inducible transcript 3	Rattus norvegicus	128-132
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	19-27	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	79-84
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	19-27	DNA-damage inducible transcript 3	Rattus norvegicus	89-93
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	19-27	caspase 12	Rattus norvegicus	180-190
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	19-27	caspase 3	Rattus norvegicus	195-204
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	29-32	heat shock protein family A (Hsp70) member 5	Rattus norvegicus	79-84
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	29-32	DNA-damage inducible transcript 3	Rattus norvegicus	89-93
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	29-32	caspase 12	Rattus norvegicus	180-190
28397086-11	2017	Graphical Abstract Piperine (PIP) reduces the expression of ER stress markers (GRP78 and CHOP) induced by pathologic stimuli and consequently decreases the activation of apoptotic caspase-12 and caspase-3; all of which contributes to its chemical chaperone and cytoprotective properties to protect renal cells against ER stress and ER stress-induced cell death, and would ultimately prevent the development of chronic kidney disease.	piperine	29-32	caspase 3	Rattus norvegicus	195-204
28330809-0	2017	Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-gamma/AKT Pathways.	piperine	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	54-64
28330809-0	2017	Piperine Attenuates Pathological Cardiac Fibrosis Via PPAR-gamma/AKT Pathways.	piperine	0-8	thymoma viral proto-oncogene 1	Mus musculus	65-68
28330809-2	2017	Previous studies have demonstrated that piperine activates AMPKalpha and reduces the phosphorylation of extracellular signal-regulated kinase (ERK).	piperine	40-48	mitogen-activated protein kinase 1	Mus musculus	104-141
28330809-2	2017	Previous studies have demonstrated that piperine activates AMPKalpha and reduces the phosphorylation of extracellular signal-regulated kinase (ERK).	piperine	40-48	mitogen-activated protein kinase 1	Mus musculus	143-146
28330809-5	2017	Piperine inhibited the transformation of cardiac fibroblasts to myofibroblasts induced by transforming growth factor-beta (TGF-beta) or angiotensin II (Ang II) in vitro.	piperine	0-8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	136-150
28330809-5	2017	Piperine inhibited the transformation of cardiac fibroblasts to myofibroblasts induced by transforming growth factor-beta (TGF-beta) or angiotensin II (Ang II) in vitro.	piperine	0-8	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	152-158
28330809-7	2017	Piperine blocked activation of protein kinase B (AKT) and, downstream, glycogen synthase kinase 3beta (GSK3beta).	piperine	0-8	thymoma viral proto-oncogene 1	Mus musculus	49-52
28330809-7	2017	Piperine blocked activation of protein kinase B (AKT) and, downstream, glycogen synthase kinase 3beta (GSK3beta).	piperine	0-8	glycogen synthase kinase 3 beta	Mus musculus	71-101
28330809-7	2017	Piperine blocked activation of protein kinase B (AKT) and, downstream, glycogen synthase kinase 3beta (GSK3beta).	piperine	0-8	glycogen synthase kinase 3 beta	Mus musculus	103-111
28330809-8	2017	The overexpression of constitutively active AKT or the knockdown of GSK3beta completely abolished the piperine-mediated protection of cardiac fibroblasts.	piperine	102-110	thymoma viral proto-oncogene 1	Mus musculus	44-47
26970969-1	2016	The aim of the present study was to investigate the protective effects of curcumin alone and in combination with piperine against lipopolysaccharide (LPS)-induced neurobehavioral and neurochemical deficits in the mice hippocampus.	piperine	113-121	toll-like receptor 4	Mus musculus	150-153
28330809-8	2017	The overexpression of constitutively active AKT or the knockdown of GSK3beta completely abolished the piperine-mediated protection of cardiac fibroblasts.	piperine	102-110	glycogen synthase kinase 3 beta	Mus musculus	68-76
28330809-9	2017	The cardioprotective effects of piperine were blocked in mice with constitutively active AKT.	piperine	32-40	thymoma viral proto-oncogene 1	Mus musculus	89-92
28330809-10	2017	Pretreatment with GW9662, a specific inhibitor of peroxisome proliferator activated receptor-gamma (PPAR-gamma), reversed the effect elicited by piperine in vitro.	piperine	145-153	peroxisome proliferator activated receptor gamma	Mus musculus	100-110
28330809-11	2017	In conclusion, piperine attenuated cardiac fibrosis via the activation of PPAR-gamma and the resultant inhibition of AKT/GSK3beta.	piperine	15-23	thymoma viral proto-oncogene 1	Mus musculus	117-120
28330809-11	2017	In conclusion, piperine attenuated cardiac fibrosis via the activation of PPAR-gamma and the resultant inhibition of AKT/GSK3beta.	piperine	15-23	glycogen synthase kinase 3 beta	Mus musculus	121-129
27981349-1	2017	PURPOSE: Piperine (PIP) has been found to inhibit P-glycoprotein (P-gp) function in rats, suggesting that it may have the potential to modulate P-gp-mediated drug efflux in humans.	piperine	9-17	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	50-64
27981349-1	2017	PURPOSE: Piperine (PIP) has been found to inhibit P-glycoprotein (P-gp) function in rats, suggesting that it may have the potential to modulate P-gp-mediated drug efflux in humans.	piperine	9-17	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	66-70
27981349-1	2017	PURPOSE: Piperine (PIP) has been found to inhibit P-glycoprotein (P-gp) function in rats, suggesting that it may have the potential to modulate P-gp-mediated drug efflux in humans.	piperine	9-17	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	144-148
27981349-1	2017	PURPOSE: Piperine (PIP) has been found to inhibit P-glycoprotein (P-gp) function in rats, suggesting that it may have the potential to modulate P-gp-mediated drug efflux in humans.	piperine	19-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	50-64
27981349-1	2017	PURPOSE: Piperine (PIP) has been found to inhibit P-glycoprotein (P-gp) function in rats, suggesting that it may have the potential to modulate P-gp-mediated drug efflux in humans.	piperine	19-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	66-70
27981349-1	2017	PURPOSE: Piperine (PIP) has been found to inhibit P-glycoprotein (P-gp) function in rats, suggesting that it may have the potential to modulate P-gp-mediated drug efflux in humans.	piperine	19-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	144-148
27981349-10	2017	CONCLUSIONS: The results suggest that altered pharmacokinetics and enhanced bioavailability of FEX might be attributed to PIP-mediated inhibition of P-gp drug efflux.	piperine	122-125	ATP binding cassette subfamily B member 1	Homo sapiens	149-153
27981349-11	2017	Therefore, intake of PIP or dietary supplements containing PIP may potentially enhance the absorption or bioavailability of P-gp substrate drugs in addition to FEX.	piperine	21-24	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
27981349-11	2017	Therefore, intake of PIP or dietary supplements containing PIP may potentially enhance the absorption or bioavailability of P-gp substrate drugs in addition to FEX.	piperine	59-62	ATP binding cassette subfamily B member 1	Homo sapiens	124-128
28102026-4	2017	Piperine inhibited B cell proliferation by causing G0/G1 phase cell cycle arrest in association with reduced expression of cyclin D2 and D3.	piperine	0-8	cyclin D2	Mus musculus	123-132
28102026-5	2017	The inhibitory effect of piperine was not mediated through transient receptor potential vanilloid-1 ion channel (TRPV1) because piperine also inhibited the proliferation of B cells from TRPV1-deficient mice.	piperine	128-136	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	186-191
28102026-6	2017	Expression of class II major histocompatibility complex molecules and costimulatory CD40 and CD86 on B lymphocytes was reduced in the presence of piperine, as was B cell-mediated antigen presentation to syngeneic T cells.	piperine	146-154	CD40 antigen	Mus musculus	84-88
28102026-6	2017	Expression of class II major histocompatibility complex molecules and costimulatory CD40 and CD86 on B lymphocytes was reduced in the presence of piperine, as was B cell-mediated antigen presentation to syngeneic T cells.	piperine	146-154	CD86 antigen	Mus musculus	93-97
28102026-7	2017	In addition, piperine inhibited B cell synthesis of interleukin (IL)-6 and IL-10 cytokines, as well as IgM, IgG2b, and IgG3 immunoglobulins.	piperine	13-21	interleukin 6	Mus musculus	52-70
28102026-7	2017	In addition, piperine inhibited B cell synthesis of interleukin (IL)-6 and IL-10 cytokines, as well as IgM, IgG2b, and IgG3 immunoglobulins.	piperine	13-21	interleukin 10	Mus musculus	75-80
28102026-7	2017	In addition, piperine inhibited B cell synthesis of interleukin (IL)-6 and IL-10 cytokines, as well as IgM, IgG2b, and IgG3 immunoglobulins.	piperine	13-21	immunoglobulin heavy constant gamma 2B	Mus musculus	108-113
28352353-10	2017	The upregulated activity of caspase-3 and expression levels of Bax/Bcl-2 were suppressed following treatment with piperine in the rats with pilocarpine-induced epilepsy.	piperine	114-122	caspase 3	Rattus norvegicus	28-37
28352353-10	2017	The upregulated activity of caspase-3 and expression levels of Bax/Bcl-2 were suppressed following treatment with piperine in the rats with pilocarpine-induced epilepsy.	piperine	114-122	BCL2 associated X, apoptosis regulator	Rattus norvegicus	63-66
28352353-10	2017	The upregulated activity of caspase-3 and expression levels of Bax/Bcl-2 were suppressed following treatment with piperine in the rats with pilocarpine-induced epilepsy.	piperine	114-122	BCL2, apoptosis regulator	Rattus norvegicus	67-72
28952262-0	2017	[Piperine regulates glucose metabolism disorder in HepG2 cells of insulin resistance models via targeting upstream target of AMPK signaling pathway].	piperine	1-9	insulin	Homo sapiens	66-73
28952262-1	2017	To investigate the effect of piperine on the disorder of glucose metabolism in the cell model with insulin resistance (IR) and explore the molecules mechanism on intervening the upstream target of AMPK signaling pathway.	piperine	29-37	insulin	Homo sapiens	99-106
28952262-5	2017	The results showed that piperine, rosiglitazone and AMPK agonist AICAR could significantly elevate the glucose consumption in insulin resistance cell models, enhance the level of APN, promote APN mRNA transcripts and increase the protein expression of Adipo receptor.	piperine	24-32	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	Homo sapiens	65-70
28952262-5	2017	The results showed that piperine, rosiglitazone and AMPK agonist AICAR could significantly elevate the glucose consumption in insulin resistance cell models, enhance the level of APN, promote APN mRNA transcripts and increase the protein expression of Adipo receptor.	piperine	24-32	insulin	Homo sapiens	126-133
28952262-5	2017	The results showed that piperine, rosiglitazone and AMPK agonist AICAR could significantly elevate the glucose consumption in insulin resistance cell models, enhance the level of APN, promote APN mRNA transcripts and increase the protein expression of Adipo receptor.	piperine	24-32	alanyl aminopeptidase, membrane	Homo sapiens	179-182
28952262-5	2017	The results showed that piperine, rosiglitazone and AMPK agonist AICAR could significantly elevate the glucose consumption in insulin resistance cell models, enhance the level of APN, promote APN mRNA transcripts and increase the protein expression of Adipo receptor.	piperine	24-32	alanyl aminopeptidase, membrane	Homo sapiens	192-195
28952262-6	2017	Meanwhile,AMPKalpha mRNA and r-AMPKalpha protein expressions were also increased in piperine treated cells, but both LEP mRNA expression and LepR protein expressions were decreased in piperine treated group.	piperine	184-192	leptin	Homo sapiens	117-120
28952262-6	2017	Meanwhile,AMPKalpha mRNA and r-AMPKalpha protein expressions were also increased in piperine treated cells, but both LEP mRNA expression and LepR protein expressions were decreased in piperine treated group.	piperine	184-192	leptin receptor	Homo sapiens	141-145
28952262-7	2017	The results indicated that piperine could significantly ameliorate the glucose metabolism disorder in insulin resistance cell models through regulating upstream molecules (APN and LEP) of AMPK signaling pathway, and thus activate the AMPK signaling pathway.	piperine	27-35	insulin	Homo sapiens	102-109
28952262-7	2017	The results indicated that piperine could significantly ameliorate the glucose metabolism disorder in insulin resistance cell models through regulating upstream molecules (APN and LEP) of AMPK signaling pathway, and thus activate the AMPK signaling pathway.	piperine	27-35	alanyl aminopeptidase, membrane	Homo sapiens	172-175
28952262-7	2017	The results indicated that piperine could significantly ameliorate the glucose metabolism disorder in insulin resistance cell models through regulating upstream molecules (APN and LEP) of AMPK signaling pathway, and thus activate the AMPK signaling pathway.	piperine	27-35	leptin	Homo sapiens	180-183
28068976-0	2017	IL-1beta-induced modulation of gene expression profile in human dermal fibroblasts: the effects of Thai herbal Sahatsatara formula, piperine and gallic acid possessing antioxidant properties.	piperine	132-140	interleukin 1 beta	Homo sapiens	0-8
27882569-6	2017	Also observed was a time-dependent inhibition of the hepatic expression of UGT1A6, 1A8, SULT1A1, 1A3, and the colonic expression of UGT1A6 that occurred within 6 h of piperine pre-treatment but was reversed at 8 h, which correlated with the changes in curcumin exposure.	piperine	167-175	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	75-81
27882569-6	2017	Also observed was a time-dependent inhibition of the hepatic expression of UGT1A6, 1A8, SULT1A1, 1A3, and the colonic expression of UGT1A6 that occurred within 6 h of piperine pre-treatment but was reversed at 8 h, which correlated with the changes in curcumin exposure.	piperine	167-175	sulfotransferase family 1A member 1	Rattus norvegicus	88-95
27882569-6	2017	Also observed was a time-dependent inhibition of the hepatic expression of UGT1A6, 1A8, SULT1A1, 1A3, and the colonic expression of UGT1A6 that occurred within 6 h of piperine pre-treatment but was reversed at 8 h, which correlated with the changes in curcumin exposure.	piperine	167-175	UDP glucuronosyltransferase family 1 member A6	Rattus norvegicus	132-138
29032766-9	2017	Piperine showed inhibition of MDR1, Bcrp1, OATP1B1, OCT1 and OCT3.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	30-34
29032766-9	2017	Piperine showed inhibition of MDR1, Bcrp1, OATP1B1, OCT1 and OCT3.	piperine	0-8	BCR pseudogene 1	Homo sapiens	36-41
29032766-9	2017	Piperine showed inhibition of MDR1, Bcrp1, OATP1B1, OCT1 and OCT3.	piperine	0-8	solute carrier organic anion transporter family member 1B1	Homo sapiens	43-50
29032766-9	2017	Piperine showed inhibition of MDR1, Bcrp1, OATP1B1, OCT1 and OCT3.	piperine	0-8	solute carrier family 22 member 1	Homo sapiens	52-56
29032766-9	2017	Piperine showed inhibition of MDR1, Bcrp1, OATP1B1, OCT1 and OCT3.	piperine	0-8	POU class 5 homeobox 1	Homo sapiens	61-65
29032766-11	2017	However, SKF525A, menadione, raloxifene and piperine can inhibit the activities of ABC and/or SLC transporters.	piperine	44-52	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	83-86
27995955-6	2016	Piperine showed specificity for G-quadruplex DNA over double stranded DNA, with highest affinity for G-quadruplex structure formed at c-myc promoter region.	piperine	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	134-139
27812336-0	2016	Piperine Suppresses Pyroptosis and Interleukin-1beta Release upon ATP Triggering and Bacterial Infection.	piperine	0-8	interleukin 1 beta	Mus musculus	35-52
27812336-4	2016	The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1beta (IL-1beta) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A.1 cells.	piperine	24-32	interleukin 1 beta	Mus musculus	104-121
27812336-4	2016	The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1beta (IL-1beta) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A.1 cells.	piperine	24-32	interleukin 1 beta	Mus musculus	123-131
27812336-4	2016	The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1beta (IL-1beta) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A.1 cells.	piperine	24-32	high mobility group box 1	Mus musculus	136-161
27812336-4	2016	The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1beta (IL-1beta) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A.1 cells.	piperine	24-32	high mobility group box 1	Mus musculus	171-176
27812336-6	2016	Moreover, piperine administration greatly reduced both peritoneal and serum IL-1beta levels in the mouse model intraperitoneally infected with Escherichia coli, suggestive of suppressing systemic inflammation and pyroptosis.	piperine	10-18	interleukin 1 beta	Mus musculus	76-84
27812336-7	2016	Our data indicated that piperine could protect macrophages from pyroptosis and reduced IL-1beta and HMGB1 release by suppressing ATP-induced AMPK activation, suggesting that piperine may become a potential therapeutic agent against bacterial sepsis.	piperine	24-32	interleukin 1 beta	Mus musculus	87-95
27812336-7	2016	Our data indicated that piperine could protect macrophages from pyroptosis and reduced IL-1beta and HMGB1 release by suppressing ATP-induced AMPK activation, suggesting that piperine may become a potential therapeutic agent against bacterial sepsis.	piperine	24-32	high mobility group box 1	Mus musculus	100-105
27812336-7	2016	Our data indicated that piperine could protect macrophages from pyroptosis and reduced IL-1beta and HMGB1 release by suppressing ATP-induced AMPK activation, suggesting that piperine may become a potential therapeutic agent against bacterial sepsis.	piperine	174-182	interleukin 1 beta	Mus musculus	87-95
30640983-1	2016	Objective To observe changes of serum neuron specific enolase (NSE) level in children patients with epilepsy by additional use of ilepcimide (piperine derivative).	piperine	142-150	enolase 2	Homo sapiens	38-61
30640983-1	2016	Objective To observe changes of serum neuron specific enolase (NSE) level in children patients with epilepsy by additional use of ilepcimide (piperine derivative).	piperine	142-150	enolase 2	Homo sapiens	63-66
30640983-31	2016	Conclusion Adding ilepcimide (piperine derivative) for epilepsy children patients could lower serum NSE level and the frequency of seizures, and improve results of EEG.	piperine	30-38	enolase 2	Homo sapiens	100-103
27052193-12	2017	The results suggest that the altered pharmacokinetics of DIC might be attributed to PIP mediated inhibition of CYP2C9 enzyme, which indicates the clinically significant interaction present between DIC and PIP.	piperine	84-87	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	111-117
28117414-0	2017	Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells.	piperine	0-8	uncoupling protein 1	Homo sapiens	19-23
28117414-0	2017	Piperine regulates UCP1 through the AMPK pathway by generating intracellular lactate production in muscle cells.	piperine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	36-40
28117414-3	2017	Piperine also induced the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target, acetyl-CoA carboxylase (ACC), while additionally stimulating glucose uptake in an AMPK dependent manner.	piperine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	45-73
28117414-3	2017	Piperine also induced the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target, acetyl-CoA carboxylase (ACC), while additionally stimulating glucose uptake in an AMPK dependent manner.	piperine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	75-79
28117414-3	2017	Piperine also induced the phosphorylation of AMP-activated protein kinase (AMPK) and its downstream target, acetyl-CoA carboxylase (ACC), while additionally stimulating glucose uptake in an AMPK dependent manner.	piperine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	190-194
28117414-4	2017	Piperine also stimulates the p38 mitogen-activated protein kinase (p38 MAPK), an effect that was reversed by pretreatment with compound C, an AMPK inhibitor.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	29-65
28117414-4	2017	Piperine also stimulates the p38 mitogen-activated protein kinase (p38 MAPK), an effect that was reversed by pretreatment with compound C, an AMPK inhibitor.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	67-75
28117414-4	2017	Piperine also stimulates the p38 mitogen-activated protein kinase (p38 MAPK), an effect that was reversed by pretreatment with compound C, an AMPK inhibitor.	piperine	0-8	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
28117414-7	2017	Knock-down of AMPK blocked piperine-induced UCP1 up-regulation, demonstrating the required role of AMPK in this effect.	piperine	27-35	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	14-18
28117414-7	2017	Knock-down of AMPK blocked piperine-induced UCP1 up-regulation, demonstrating the required role of AMPK in this effect.	piperine	27-35	uncoupling protein 1	Homo sapiens	44-48
28117414-7	2017	Knock-down of AMPK blocked piperine-induced UCP1 up-regulation, demonstrating the required role of AMPK in this effect.	piperine	27-35	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	99-103
28117414-8	2017	Taken together, these results suggest that piperine leads to benign metabolic effects by activating the AMPK-p38 MAPK signaling pathway and UCP1 expression by activating intracellular lactate production in skeletal muscle.	piperine	43-51	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	104-108
28117414-8	2017	Taken together, these results suggest that piperine leads to benign metabolic effects by activating the AMPK-p38 MAPK signaling pathway and UCP1 expression by activating intracellular lactate production in skeletal muscle.	piperine	43-51	mitogen-activated protein kinase 14	Homo sapiens	109-117
28117414-8	2017	Taken together, these results suggest that piperine leads to benign metabolic effects by activating the AMPK-p38 MAPK signaling pathway and UCP1 expression by activating intracellular lactate production in skeletal muscle.	piperine	43-51	uncoupling protein 1	Homo sapiens	140-144
27821437-4	2017	SC-mediated inhibition of CYP3A4 was found to rank in the order of CAP (IC50 1.84 +- 0.71 microM) ~ PIP (2.12 +- 0.45 microM) &gt; CUR (11.93 +- 3.49 microM), while CYP2C9 inhibition was in the order of CAP (11.95 +- 4.24 microM) ~ CUR (14.58 +- 4.57 microM) &gt; PIP (89.62 +- 9.17 microM).	piperine	100-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	26-32
27821437-4	2017	SC-mediated inhibition of CYP3A4 was found to rank in the order of CAP (IC50 1.84 +- 0.71 microM) ~ PIP (2.12 +- 0.45 microM) &gt; CUR (11.93 +- 3.49 microM), while CYP2C9 inhibition was in the order of CAP (11.95 +- 4.24 microM) ~ CUR (14.58 +- 4.57 microM) &gt; PIP (89.62 +- 9.17 microM).	piperine	264-267	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	26-32
27821437-5	2017	CAP and PIP were significantly more potent inhibitors of CYP1A2 (IC50 2.14 +- 0.22 microM and 14.19 +- 4.15 microM, respectively) than CUR (IC50 &gt; 100 microM), while all three SCs exhibited weak activity toward CYP2D6 (IC50 95.42 +- 12.09 microM for CUR, 99.99 +- 5.88 microM for CAP, and 110.40 +- 3.23 microM for PIP).	piperine	8-11	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
27821437-5	2017	CAP and PIP were significantly more potent inhibitors of CYP1A2 (IC50 2.14 +- 0.22 microM and 14.19 +- 4.15 microM, respectively) than CUR (IC50 &gt; 100 microM), while all three SCs exhibited weak activity toward CYP2D6 (IC50 95.42 +- 12.09 microM for CUR, 99.99 +- 5.88 microM for CAP, and 110.40 +- 3.23 microM for PIP).	piperine	8-11	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	214-220
27875748-0	2017	Piperine attenuates lipopolysaccharide (LPS)-induced inflammatory responses in BV2 microglia.	piperine	0-8	toll-like receptor 4	Mus musculus	40-43
27875748-4	2017	The results showed that piperine significantly inhibited LPS-induced TNF-alpha, IL-6, IL-1beta, and PGE2 production in BV2 cells.	piperine	24-32	toll-like receptor 4	Mus musculus	57-60
27875748-4	2017	The results showed that piperine significantly inhibited LPS-induced TNF-alpha, IL-6, IL-1beta, and PGE2 production in BV2 cells.	piperine	24-32	tumor necrosis factor	Mus musculus	69-78
27875748-4	2017	The results showed that piperine significantly inhibited LPS-induced TNF-alpha, IL-6, IL-1beta, and PGE2 production in BV2 cells.	piperine	24-32	interleukin 6	Mus musculus	80-84
27875748-4	2017	The results showed that piperine significantly inhibited LPS-induced TNF-alpha, IL-6, IL-1beta, and PGE2 production in BV2 cells.	piperine	24-32	interleukin 1 beta	Mus musculus	86-94
27875748-5	2017	Western blot analysis showed that piperine dose-dependently inhibited LPS-induced NF-kappaB activation.	piperine	34-42	toll-like receptor 4	Mus musculus	70-73
27875748-6	2017	Furthermore, piperine was found to amplify the expression of Nrf2 and HO-1 up-regulated by LPS.	piperine	13-21	nuclear factor, erythroid derived 2, like 2	Mus musculus	61-65
27875748-6	2017	Furthermore, piperine was found to amplify the expression of Nrf2 and HO-1 up-regulated by LPS.	piperine	13-21	heme oxygenase 1	Mus musculus	70-74
27875748-6	2017	Furthermore, piperine was found to amplify the expression of Nrf2 and HO-1 up-regulated by LPS.	piperine	13-21	toll-like receptor 4	Mus musculus	91-94
27875748-7	2017	In addition, the inhibition of inflammatory mediators by piperine can be reversed by transfection with Nrf2 siRNA.	piperine	57-65	nuclear factor, erythroid derived 2, like 2	Mus musculus	103-107
27875748-8	2017	In conclusion, piperine inhibited LPS-induced inflammatory response by activating Nrf2 signaling pathway.	piperine	15-23	toll-like receptor 4	Mus musculus	34-37
27875748-8	2017	In conclusion, piperine inhibited LPS-induced inflammatory response by activating Nrf2 signaling pathway.	piperine	15-23	nuclear factor, erythroid derived 2, like 2	Mus musculus	82-86
28459658-3	2017	Piperine, the main alkaloid present in black pepper has been reported to show inhibitory effects on Cytochrome P-450 (CYP-450) enzymes and P-glycoprotein (P-gp).	piperine	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	100-116
28459658-3	2017	Piperine, the main alkaloid present in black pepper has been reported to show inhibitory effects on Cytochrome P-450 (CYP-450) enzymes and P-glycoprotein (P-gp).	piperine	0-8	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	118-125
28459658-3	2017	Piperine, the main alkaloid present in black pepper has been reported to show inhibitory effects on Cytochrome P-450 (CYP-450) enzymes and P-glycoprotein (P-gp).	piperine	0-8	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	139-153
28459658-3	2017	Piperine, the main alkaloid present in black pepper has been reported to show inhibitory effects on Cytochrome P-450 (CYP-450) enzymes and P-glycoprotein (P-gp).	piperine	0-8	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	155-159
28459658-11	2017	CONCLUSIONS: Piperine enhanced the oral bioavailability of domperidone by inhibiting CYP3A1 and P-gp in rats.	piperine	13-21	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	85-91
28459658-11	2017	CONCLUSIONS: Piperine enhanced the oral bioavailability of domperidone by inhibiting CYP3A1 and P-gp in rats.	piperine	13-21	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	96-100
28123572-0	2017	Solid lipid nanoparticles with TPGS and Brij 78: A co-delivery vehicle of curcumin and piperine for reversing P-glycoprotein-mediated multidrug resistance in vitro.	piperine	87-95	ATP binding cassette subfamily B member 1	Homo sapiens	110-124
27756602-0	2016	Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells.	piperine	22-30	BCL2 associated X, apoptosis regulator	Homo sapiens	70-73
27756602-0	2016	Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells.	piperine	22-30	BCL2 apoptosis regulator	Homo sapiens	74-79
27756602-0	2016	Synergistic effect of piperine and paclitaxel on cell fate via cyt-c, Bax/Bcl-2-caspase-3 pathway in ovarian adenocarcinomas SKOV-3 cells.	piperine	22-30	caspase 3	Homo sapiens	80-89
27812336-7	2016	Our data indicated that piperine could protect macrophages from pyroptosis and reduced IL-1beta and HMGB1 release by suppressing ATP-induced AMPK activation, suggesting that piperine may become a potential therapeutic agent against bacterial sepsis.	piperine	174-182	high mobility group box 1	Mus musculus	100-105
27572322-0	2016	Piperine induces autophagy by enhancing protein phosphotase 2A activity in a rotenone-induced Parkinson"s disease model.	piperine	0-8	protein phosphatase 2 phosphatase activator	Homo sapiens	48-62
27572322-8	2016	In addition, PIP induced autophagy by inhibiting mammalian target of rapamycin complex 1(mTORC1) via activation of protein phosphotase 2A (PP2A).	piperine	13-16	CREB regulated transcription coactivator 1	Mus musculus	89-95
27572322-8	2016	In addition, PIP induced autophagy by inhibiting mammalian target of rapamycin complex 1(mTORC1) via activation of protein phosphotase 2A (PP2A).	piperine	13-16	protein phosphatase 2 phosphatase activator	Homo sapiens	123-137
27572322-8	2016	In addition, PIP induced autophagy by inhibiting mammalian target of rapamycin complex 1(mTORC1) via activation of protein phosphotase 2A (PP2A).	piperine	13-16	protein phosphatase 2 phosphatase activator	Homo sapiens	139-143
27572322-9	2016	However, inhibiting PP2A activity with okadaic acid reduced these protective effects, suggesting that PP2A is a target of PIP.	piperine	122-125	protein phosphatase 2 phosphatase activator	Homo sapiens	20-24
27572322-9	2016	However, inhibiting PP2A activity with okadaic acid reduced these protective effects, suggesting that PP2A is a target of PIP.	piperine	122-125	protein phosphatase 2 phosphatase activator	Homo sapiens	102-106
27266851-9	2016	CEP, Pip or their combination significantly decreased TXNIP and NLRP3 expression in diabetic kidneys.	piperine	5-8	thioredoxin interacting protein	Rattus norvegicus	54-59
27266851-9	2016	CEP, Pip or their combination significantly decreased TXNIP and NLRP3 expression in diabetic kidneys.	piperine	5-8	NLR family, pyrin domain containing 3	Rattus norvegicus	64-69
27266851-11	2016	CEP, Pip or their combination showed significant inhibition of NF-kappaB together with decreased IL-1beta and TNF-alpha levels in diabetic rats.	piperine	5-8	interleukin 1 beta	Rattus norvegicus	97-105
27266851-11	2016	CEP, Pip or their combination showed significant inhibition of NF-kappaB together with decreased IL-1beta and TNF-alpha levels in diabetic rats.	piperine	5-8	tumor necrosis factor	Rattus norvegicus	110-119
26970969-11	2016	These results demonstrate that piperine enhanced the neuroprotective effect of curcumin against LPS-induced neurobehavioral and neurochemical deficits.	piperine	31-39	toll-like receptor 4	Mus musculus	96-99
25736698-12	2015	Piperine (100 mg/kg) significantly downregulated the expressions of IL-1beta, MMP-8 and MMP-13 in periodontitis, but not that of TNF-alpha.	piperine	0-8	interleukin 1 beta	Rattus norvegicus	68-76
26410851-5	2016	Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	piperine	30-38	myeloperoxidase	Homo sapiens	62-65
26410851-5	2016	Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	piperine	30-38	tumor necrosis factor	Homo sapiens	115-124
26410851-5	2016	Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	piperine	30-38	interleukin 6	Homo sapiens	126-130
28018704-5	2016	The highly selected imprinted polymer for Piperine was MIP 3 with a composition (molar ratio) of 0.5 : 3 : 8, template : monomer : cross-linker, respectively.	piperine	42-50	C-C motif chemokine ligand 23	Homo sapiens	55-60
29879347-8	2016	Dopamine, glutamine, piperine, berberine, nuciferine, lisinopril and fosinopril could inhibit ergothioneine or mildronate uptake by MDCK- hOCTN1/2.	piperine	21-29	solute carrier family 22 member 4	Homo sapiens	138-146
26640239-3	2016	In addition, piperine-treated DCs had reduced CCR7 expression and elevated CCR5 expression, as well as reduced expression of CD40 and class II major histocompatibility complex molecules and decreased nuclear accumulation of RelB.	piperine	13-21	chemokine (C-C motif) receptor 7	Mus musculus	46-50
26640239-3	2016	In addition, piperine-treated DCs had reduced CCR7 expression and elevated CCR5 expression, as well as reduced expression of CD40 and class II major histocompatibility complex molecules and decreased nuclear accumulation of RelB.	piperine	13-21	chemokine (C-C motif) receptor 5	Mus musculus	75-79
26640239-3	2016	In addition, piperine-treated DCs had reduced CCR7 expression and elevated CCR5 expression, as well as reduced expression of CD40 and class II major histocompatibility complex molecules and decreased nuclear accumulation of RelB.	piperine	13-21	CD40 antigen	Mus musculus	125-129
26640239-3	2016	In addition, piperine-treated DCs had reduced CCR7 expression and elevated CCR5 expression, as well as reduced expression of CD40 and class II major histocompatibility complex molecules and decreased nuclear accumulation of RelB.	piperine	13-21	avian reticuloendotheliosis viral (v-rel) oncogene related B	Mus musculus	224-228
26640239-4	2016	DC production of interleukin (IL)-6, tumor necrosis factor alpha, and monocyte chemoattractant protein-1 in response to lipopolysaccharide stimulation was also reduced following piperine treatment.	piperine	178-186	interleukin 6	Mus musculus	17-35
26640239-4	2016	DC production of interleukin (IL)-6, tumor necrosis factor alpha, and monocyte chemoattractant protein-1 in response to lipopolysaccharide stimulation was also reduced following piperine treatment.	piperine	178-186	tumor necrosis factor	Mus musculus	37-64
26640239-4	2016	DC production of interleukin (IL)-6, tumor necrosis factor alpha, and monocyte chemoattractant protein-1 in response to lipopolysaccharide stimulation was also reduced following piperine treatment.	piperine	178-186	chemokine (C-C motif) ligand 2	Mus musculus	70-104
26640239-5	2016	Exposure to piperine during maturation therefore caused DCs to retain an immature phenotype, which was associated with a reduced capacity to promote T cell activation since co-culture of ovalbumin (OVA323-339)-specific T cells with OVA323-339-pulsed DCs that were previously matured in the presence of piperine showed reduced interferon-gamma and IL-2 expression.	piperine	12-20	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	187-196
26640239-5	2016	Exposure to piperine during maturation therefore caused DCs to retain an immature phenotype, which was associated with a reduced capacity to promote T cell activation since co-culture of ovalbumin (OVA323-339)-specific T cells with OVA323-339-pulsed DCs that were previously matured in the presence of piperine showed reduced interferon-gamma and IL-2 expression.	piperine	12-20	interferon gamma	Mus musculus	326-342
26640239-5	2016	Exposure to piperine during maturation therefore caused DCs to retain an immature phenotype, which was associated with a reduced capacity to promote T cell activation since co-culture of ovalbumin (OVA323-339)-specific T cells with OVA323-339-pulsed DCs that were previously matured in the presence of piperine showed reduced interferon-gamma and IL-2 expression.	piperine	12-20	interleukin 2	Mus musculus	347-351
26410851-5	2016	Our results demonstrated that piperine attenuated LPS-induced MPO activity, lung edema, and inflammatory cytokines TNF-alpha, IL-6, and IL-1beta production.	piperine	30-38	interleukin 1 beta	Homo sapiens	136-144
25736698-12	2015	Piperine (100 mg/kg) significantly downregulated the expressions of IL-1beta, MMP-8 and MMP-13 in periodontitis, but not that of TNF-alpha.	piperine	0-8	matrix metallopeptidase 8	Rattus norvegicus	78-83
25736698-12	2015	Piperine (100 mg/kg) significantly downregulated the expressions of IL-1beta, MMP-8 and MMP-13 in periodontitis, but not that of TNF-alpha.	piperine	0-8	matrix metallopeptidase 13	Rattus norvegicus	88-94
26627060-8	2015	Concomitantly, expression of c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), the key transcription factors involved in osteoclastogenesis were remarkably inhibited by piperine.	piperine	190-198	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
26627060-0	2015	Piperine alleviates osteoclast formation through the p38/c-Fos/NFATc1 signaling axis.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	53-56
26627060-8	2015	Concomitantly, expression of c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), the key transcription factors involved in osteoclastogenesis were remarkably inhibited by piperine.	piperine	190-198	nuclear factor of activated T cells 1	Homo sapiens	39-89
26627060-0	2015	Piperine alleviates osteoclast formation through the p38/c-Fos/NFATc1 signaling axis.	piperine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
26627060-8	2015	Concomitantly, expression of c-Fos and nuclear factor of activated T-cells, cytoplasmic 1 (NFATc1), the key transcription factors involved in osteoclastogenesis were remarkably inhibited by piperine.	piperine	190-198	nuclear factor of activated T cells 1	Homo sapiens	91-97
26627060-0	2015	Piperine alleviates osteoclast formation through the p38/c-Fos/NFATc1 signaling axis.	piperine	0-8	nuclear factor of activated T cells 1	Homo sapiens	63-69
26627060-10	2015	Collectively, these results suggested that piperine inhibited osteoclast differentiation by suppressing the p38/NFATc1/c-Fos signaling axis..	piperine	43-51	mitogen-activated protein kinase 14	Homo sapiens	108-111
26627060-6	2015	Piperine inhibited tartrate-resistant acid phosphatase-positive multinucleated osteoclast formation in murine RAW264.7 macrophages and human CD14+ monocytes induced by RANKL and breast cancer cells.	piperine	0-8	CD14 molecule	Homo sapiens	141-145
26627060-10	2015	Collectively, these results suggested that piperine inhibited osteoclast differentiation by suppressing the p38/NFATc1/c-Fos signaling axis..	piperine	43-51	nuclear factor of activated T cells 1	Homo sapiens	112-118
26627060-6	2015	Piperine inhibited tartrate-resistant acid phosphatase-positive multinucleated osteoclast formation in murine RAW264.7 macrophages and human CD14+ monocytes induced by RANKL and breast cancer cells.	piperine	0-8	TNF superfamily member 11	Homo sapiens	168-173
26627060-10	2015	Collectively, these results suggested that piperine inhibited osteoclast differentiation by suppressing the p38/NFATc1/c-Fos signaling axis..	piperine	43-51	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	119-124
26627060-7	2015	Piperine attenuated the p38-mitogen activated protein kinase pathway activation, while the extracellular-signal-regulated kinase, c-Jun N-terminal kinase, or NF-kappabeta pathways downstream of RANKL remained unaffected.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	24-27
24819444-3	2015	Piperine inhibited HT-29 colon carcinoma cell proliferation by causing G1 phase cell cycle arrest that was associated with decreased expression of cyclins D1 and D3 and their activating partner cyclin-dependent kinases 4 and 6, as well as reduced phosphorylation of the retinoblastoma protein and up-regulation of p21/WAF1 and p27/KIP1 expression.	piperine	0-8	interferon alpha inducible protein 27	Homo sapiens	327-330
26648012-12	2015	Additionally, piperine reduced the number of activated microglia, expression of cytokine IL-1beta, and oxidative stress following MPTP treatment.	piperine	14-22	interleukin 1 alpha	Mus musculus	89-97
26648012-13	2015	An anti-apoptotic property of piperine was identified by maintaining the balance of Bcl-2/Bax.	piperine	30-38	B cell leukemia/lymphoma 2	Mus musculus	84-89
26648012-13	2015	An anti-apoptotic property of piperine was identified by maintaining the balance of Bcl-2/Bax.	piperine	30-38	BCL2-associated X protein	Mus musculus	90-93
26431033-8	2015	Finally, the knockdown of SREBPs completely abolished the piperine-meditated induction of LDLR gene expression in HepG2 cells, indicating that piperine stimulates the proteolytic activation of SREBP and subsequent induction of LDLR expression and activity.	piperine	143-151	low density lipoprotein receptor	Homo sapiens	227-231
26300429-8	2015	Although curcumin caused already significant effects, the combination with piperine completely suppressed the osteoclastogenesis by decreasing the TRAP activity and inhibiting the expression of the specific osteoclast markers TRAP, cathepsin K, and calcitonin receptor.	piperine	75-83	cathepsin K	Homo sapiens	232-243
25900378-4	2015	Piperine also suppressed T lymphocyte entry into the S and G2 /M phases of the cell cycle, and decreased expression of G1 -associated cyclin D3, CDK4, and CDK6.	piperine	0-8	cyclin D3	Mus musculus	134-143
25900378-4	2015	Piperine also suppressed T lymphocyte entry into the S and G2 /M phases of the cell cycle, and decreased expression of G1 -associated cyclin D3, CDK4, and CDK6.	piperine	0-8	cyclin-dependent kinase 4	Mus musculus	145-149
25900378-4	2015	Piperine also suppressed T lymphocyte entry into the S and G2 /M phases of the cell cycle, and decreased expression of G1 -associated cyclin D3, CDK4, and CDK6.	piperine	0-8	cyclin-dependent kinase 6	Mus musculus	155-159
25900378-5	2015	In addition, piperine inhibited CD25 expression, synthesis of interferon-gamma, interleukin (IL)-2, IL-4, and IL-17A, and the generation of cytotoxic effector cells.	piperine	13-21	interleukin 2 receptor, alpha chain	Mus musculus	32-36
25900378-5	2015	In addition, piperine inhibited CD25 expression, synthesis of interferon-gamma, interleukin (IL)-2, IL-4, and IL-17A, and the generation of cytotoxic effector cells.	piperine	13-21	interferon gamma	Mus musculus	62-78
25900378-5	2015	In addition, piperine inhibited CD25 expression, synthesis of interferon-gamma, interleukin (IL)-2, IL-4, and IL-17A, and the generation of cytotoxic effector cells.	piperine	13-21	interleukin 4	Mus musculus	100-104
25900378-5	2015	In addition, piperine inhibited CD25 expression, synthesis of interferon-gamma, interleukin (IL)-2, IL-4, and IL-17A, and the generation of cytotoxic effector cells.	piperine	13-21	interleukin 17A	Mus musculus	110-116
25900378-6	2015	The inhibitory effect of piperine on T lymphocytes was associated with hypophosphorylation of Akt, extracellular signal-regulated kinase, and inhibitor of kappaBalpha, but not ZAP-70.	piperine	25-33	thymoma viral proto-oncogene 1	Mus musculus	94-97
26439699-4	2015	Here we report that piperine robustly boosts mTORC1 activity by recruiting more system L1 amino acid transporter (SLC7A5/SLC3A2) to the cell membrane, thus promoting amino acid metabolism.	piperine	20-28	CREB regulated transcription coactivator 1	Mus musculus	45-51
26439699-4	2015	Here we report that piperine robustly boosts mTORC1 activity by recruiting more system L1 amino acid transporter (SLC7A5/SLC3A2) to the cell membrane, thus promoting amino acid metabolism.	piperine	20-28	solute carrier family 7 (cationic amino acid transporter, y+ system), member 5	Mus musculus	114-120
26439699-4	2015	Here we report that piperine robustly boosts mTORC1 activity by recruiting more system L1 amino acid transporter (SLC7A5/SLC3A2) to the cell membrane, thus promoting amino acid metabolism.	piperine	20-28	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	121-127
26439699-5	2015	Piperine-induced increase of mTORC1 activity in resident peritoneal macrophages (pMPhis) is correlated with enhanced production of IL-6 and TNF-alpha upon LPS stimulation.	piperine	0-8	CREB regulated transcription coactivator 1	Mus musculus	29-35
26439699-5	2015	Piperine-induced increase of mTORC1 activity in resident peritoneal macrophages (pMPhis) is correlated with enhanced production of IL-6 and TNF-alpha upon LPS stimulation.	piperine	0-8	interleukin 6	Mus musculus	131-135
26439699-5	2015	Piperine-induced increase of mTORC1 activity in resident peritoneal macrophages (pMPhis) is correlated with enhanced production of IL-6 and TNF-alpha upon LPS stimulation.	piperine	0-8	tumor necrosis factor	Mus musculus	140-149
26431033-0	2015	Piperine Induces Hepatic Low-Density Lipoprotein Receptor Expression through Proteolytic Activation of Sterol Regulatory Element-Binding Proteins.	piperine	0-8	low density lipoprotein receptor	Homo sapiens	25-57
26431033-4	2015	The treatment of HepG2 cells with piperine increased LDLR expression at mRNA and protein levels and stimulated LDL uptake.	piperine	34-42	low density lipoprotein receptor	Homo sapiens	53-57
26431033-5	2015	Subsequent luciferase reporter gene assays revealed that the mutation of sterol regulatory element-binding protein (SREBP)-binding element abolished the piperine-mediated induction of LDLR promoter activity.	piperine	153-161	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	73-114
26431033-5	2015	Subsequent luciferase reporter gene assays revealed that the mutation of sterol regulatory element-binding protein (SREBP)-binding element abolished the piperine-mediated induction of LDLR promoter activity.	piperine	153-161	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	116-121
26431033-5	2015	Subsequent luciferase reporter gene assays revealed that the mutation of sterol regulatory element-binding protein (SREBP)-binding element abolished the piperine-mediated induction of LDLR promoter activity.	piperine	153-161	low density lipoprotein receptor	Homo sapiens	184-188
26431033-6	2015	Further, piperine treatments increased mRNA levels of several SREBP targets and mature forms of SREBPs.	piperine	9-17	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	62-67
26431033-7	2015	However, the piperine-mediated induction of the mature forms of SREBPs was not observed in SRD-15 cells, which lack insulin-induced gene-1 (Insig-1) and Insig-2.	piperine	13-21	insulin induced gene 1	Homo sapiens	116-147
26431033-7	2015	However, the piperine-mediated induction of the mature forms of SREBPs was not observed in SRD-15 cells, which lack insulin-induced gene-1 (Insig-1) and Insig-2.	piperine	13-21	insulin induced gene 2	Homo sapiens	153-160
26431033-8	2015	Finally, the knockdown of SREBPs completely abolished the piperine-meditated induction of LDLR gene expression in HepG2 cells, indicating that piperine stimulates the proteolytic activation of SREBP and subsequent induction of LDLR expression and activity.	piperine	58-66	low density lipoprotein receptor	Homo sapiens	90-94
26431033-8	2015	Finally, the knockdown of SREBPs completely abolished the piperine-meditated induction of LDLR gene expression in HepG2 cells, indicating that piperine stimulates the proteolytic activation of SREBP and subsequent induction of LDLR expression and activity.	piperine	58-66	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	26-31
26431033-8	2015	Finally, the knockdown of SREBPs completely abolished the piperine-meditated induction of LDLR gene expression in HepG2 cells, indicating that piperine stimulates the proteolytic activation of SREBP and subsequent induction of LDLR expression and activity.	piperine	58-66	low density lipoprotein receptor	Homo sapiens	227-231
26431033-8	2015	Finally, the knockdown of SREBPs completely abolished the piperine-meditated induction of LDLR gene expression in HepG2 cells, indicating that piperine stimulates the proteolytic activation of SREBP and subsequent induction of LDLR expression and activity.	piperine	143-151	low density lipoprotein receptor	Homo sapiens	90-94
26431033-8	2015	Finally, the knockdown of SREBPs completely abolished the piperine-meditated induction of LDLR gene expression in HepG2 cells, indicating that piperine stimulates the proteolytic activation of SREBP and subsequent induction of LDLR expression and activity.	piperine	143-151	CCHC-type zinc finger nucleic acid binding protein	Homo sapiens	26-31
24819444-3	2015	Piperine inhibited HT-29 colon carcinoma cell proliferation by causing G1 phase cell cycle arrest that was associated with decreased expression of cyclins D1 and D3 and their activating partner cyclin-dependent kinases 4 and 6, as well as reduced phosphorylation of the retinoblastoma protein and up-regulation of p21/WAF1 and p27/KIP1 expression.	piperine	0-8	cyclin D1	Homo sapiens	147-226
24819444-3	2015	Piperine inhibited HT-29 colon carcinoma cell proliferation by causing G1 phase cell cycle arrest that was associated with decreased expression of cyclins D1 and D3 and their activating partner cyclin-dependent kinases 4 and 6, as well as reduced phosphorylation of the retinoblastoma protein and up-regulation of p21/WAF1 and p27/KIP1 expression.	piperine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	314-317
24819444-3	2015	Piperine inhibited HT-29 colon carcinoma cell proliferation by causing G1 phase cell cycle arrest that was associated with decreased expression of cyclins D1 and D3 and their activating partner cyclin-dependent kinases 4 and 6, as well as reduced phosphorylation of the retinoblastoma protein and up-regulation of p21/WAF1 and p27/KIP1 expression.	piperine	0-8	cyclin dependent kinase inhibitor 1A	Homo sapiens	318-322
24819444-3	2015	Piperine inhibited HT-29 colon carcinoma cell proliferation by causing G1 phase cell cycle arrest that was associated with decreased expression of cyclins D1 and D3 and their activating partner cyclin-dependent kinases 4 and 6, as well as reduced phosphorylation of the retinoblastoma protein and up-regulation of p21/WAF1 and p27/KIP1 expression.	piperine	0-8	cyclin dependent kinase inhibitor 1B	Homo sapiens	331-335
24819444-5	2015	Piperine-treated HT-29 cells showed loss of mitochondrial membrane integrity and cleavage of poly (ADP-ribose) polymerase-1, as well as caspase activation and reduced apoptosis in the presence of the pan-caspase inhibitor zVAD-FMK.	piperine	0-8	poly(ADP-ribose) polymerase 1	Homo sapiens	93-123
26297981-8	2015	The mechanisms of piperine-induced CFTR inhibition did not involve MRP4-mediated cAMP efflux, AMPK or TRPV1.	piperine	18-26	CF transmembrane conductance regulator	Homo sapiens	35-39
26297981-11	2015	Collectively, this study indicates that the anti-secretory effect of piperine involves the inhibition of CFTR, CaCC and cAMP-activated basolateral K+ channels.	piperine	69-77	CF transmembrane conductance regulator	Homo sapiens	105-109
26548081-4	2015	In the present study, we explored the binding interactions of antidiabetic drugs i.e., sulfonylurea drugs (glimepiride, glipizide, glyburide) and rapid acting insulin secretagogues viz., nateglinide, repaglinide and rosiglitazone; and Pgp inhibitors i.e., Generation I (verapamil and tamoxifen), III (tetradrine and tariquidar), and natural inhibitors (fumagillin and piperine) in mouse Pgp model.	piperine	368-376	insulin	Homo sapiens	159-166
26548081-6	2015	These observations elucidate the role of fumagillin and piperine as potential natural compounds which could intervene in the efflux action of Pgp in extruding the antidiabetic drugs and may have implications for increasing efficacy of oral antidiabetic therapy.	piperine	56-64	phosphoglycolate phosphatase	Mus musculus	142-145
25907981-0	2015	The protective effect of piperine on dextran sulfate sodium induced inflammatory bowel disease and its relation with pregnane X receptor activation.	piperine	25-33	nuclear receptor subfamily 1, group I, member 2	Mus musculus	117-136
26093789-2	2015	Piperine as a pungent alkaloid has been identified as the most potent adjuvant at enhancing the efficacy of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapies in triple-negative breast cancer (TNBC) cells in vitro and in vivo, which might be mediated through inhibition of Survivin.	piperine	0-8	TNF superfamily member 10	Homo sapiens	108-163
26093789-2	2015	Piperine as a pungent alkaloid has been identified as the most potent adjuvant at enhancing the efficacy of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-based therapies in triple-negative breast cancer (TNBC) cells in vitro and in vivo, which might be mediated through inhibition of Survivin.	piperine	0-8	TNF superfamily member 10	Homo sapiens	165-170
25907981-4	2015	In the present study, the effects of piperine on pregnane X receptor (PXR)-mediated CYP3A expression and its therapeutic role in IBD were investigated.	piperine	37-45	nuclear receptor subfamily 1, group I, member 2	Mus musculus	49-68
25907981-4	2015	In the present study, the effects of piperine on pregnane X receptor (PXR)-mediated CYP3A expression and its therapeutic role in IBD were investigated.	piperine	37-45	nuclear receptor subfamily 1, group I, member 2	Mus musculus	70-73
25907981-7	2015	RESULTS: Data indicated that treatment of LS174T cells with piperine markedly increased both CYP3A4 and PXR mRNA and protein.	piperine	60-68	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99
25907981-7	2015	RESULTS: Data indicated that treatment of LS174T cells with piperine markedly increased both CYP3A4 and PXR mRNA and protein.	piperine	60-68	nuclear receptor subfamily 1 group I member 2	Homo sapiens	104-107
25907981-8	2015	Transient transfection experiments indicated that transcriptional activation of the CYP3A4 gene via piperine was PXR-dependent.	piperine	100-108	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	84-90
25907981-8	2015	Transient transfection experiments indicated that transcriptional activation of the CYP3A4 gene via piperine was PXR-dependent.	piperine	100-108	nuclear receptor subfamily 1, group I, member 2	Mus musculus	113-116
25907981-9	2015	Data show that pre-administration of piperine decreased clinical hallmarks of colitis in DSS-treated PXR mice as measured by body weight loss and assessment of diarrhea, rectal bleeding, colon length, and histology.	piperine	37-45	nuclear receptor subfamily 1, group I, member 2	Mus musculus	101-104
25907981-10	2015	Inflammatory mediators (CCR2, ICAM-1, IL-1beta, IL-6, IL-10, iNOS, MCP-1, and TNFalpha) after DSS treatment were significantly decreased in mice pretreated with piperine but corresponding conditions did not occur in mice with down-regulation of PXR by small interfering RNA (siRNA).	piperine	161-169	intercellular adhesion molecule 1	Mus musculus	30-36
25907981-10	2015	Inflammatory mediators (CCR2, ICAM-1, IL-1beta, IL-6, IL-10, iNOS, MCP-1, and TNFalpha) after DSS treatment were significantly decreased in mice pretreated with piperine but corresponding conditions did not occur in mice with down-regulation of PXR by small interfering RNA (siRNA).	piperine	161-169	interleukin 1 beta	Mus musculus	38-46
25907981-10	2015	Inflammatory mediators (CCR2, ICAM-1, IL-1beta, IL-6, IL-10, iNOS, MCP-1, and TNFalpha) after DSS treatment were significantly decreased in mice pretreated with piperine but corresponding conditions did not occur in mice with down-regulation of PXR by small interfering RNA (siRNA).	piperine	161-169	nuclear receptor subfamily 1, group I, member 2	Mus musculus	245-248
25907981-11	2015	CONCLUSION: Piperine is a potential agonist of PXR and an inducer of PXR, which may induce CYP3A4 gene expression at the mRNA and protein levels.	piperine	12-20	nuclear receptor subfamily 1, group I, member 2	Mus musculus	47-50
25907981-11	2015	CONCLUSION: Piperine is a potential agonist of PXR and an inducer of PXR, which may induce CYP3A4 gene expression at the mRNA and protein levels.	piperine	12-20	nuclear receptor subfamily 1, group I, member 2	Mus musculus	69-72
25907981-11	2015	CONCLUSION: Piperine is a potential agonist of PXR and an inducer of PXR, which may induce CYP3A4 gene expression at the mRNA and protein levels.	piperine	12-20	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	91-97
26261497-9	2015	Western blot results showed that piperine inhibited the LPS-mediated phosphorylation of JNK and activation of NF-kappaB.	piperine	33-41	mitogen-activated protein kinase 8	Rattus norvegicus	88-91
26039262-0	2015	In Silico and In Vitro Investigation of the Piperine"s Male Contraceptive Effect: Docking and Molecular Dynamics Simulation Studies in Androgen-Binding Protein and Androgen Receptor.	piperine	44-52	androgen receptor	Homo sapiens	164-181
25683300-0	2015	Effect of piperine on inhibition of FFA induced TLR4 mediated inflammation and amelioration of acetic acid induced ulcerative colitis in mice.	piperine	10-18	toll-like receptor 4	Mus musculus	48-52
25683300-3	2015	Piperine exhibits antidepressant, hepatoprotective, anti-metastatic, anti-thyroid, immunomodulatory, antitumor and anti-inflammatory activities, However its therapeutic potential in amelioration of ulcerative colitis and the underlying mechanism for anti-inflammatory activity remains unknown.The objective of the present investigation was to unravel the therapeutic potential of piperine on amelioration of IBD using acetic acid induced experimental animal model for ulcerative colitis and to determine the role of TLR4 receptor in signalling pathway of inflammatory gene expression in ulcerative colitis.	piperine	0-8	toll-like receptor 4	Mus musculus	516-520
25683300-12	2015	Furthermore piperine inhibited abnormal secretion of pro-inflammatory mediators namely NO, cytokines TNF-alpha and reduces FFA induced TLR4 mediated inflammation.	piperine	12-20	tumor necrosis factor	Mus musculus	101-110
25683300-12	2015	Furthermore piperine inhibited abnormal secretion of pro-inflammatory mediators namely NO, cytokines TNF-alpha and reduces FFA induced TLR4 mediated inflammation.	piperine	12-20	toll-like receptor 4	Mus musculus	135-139
25683300-13	2015	CONCLUSION: These results suggest that piperine has an anti-inflammatory effect at colorectal sites that is due to down- regulations of the productions and expression of inflammatory mediators and it also reduces FFA induced TLR4 mediated inflammation.	piperine	39-47	toll-like receptor 4	Mus musculus	225-229
25655587-0	2015	Piperine blocks interleukin-2-driven cell cycle progression in CTLL-2 T lymphocytes by inhibiting multiple signal transduction pathways.	piperine	0-8	interleukin 2	Mus musculus	16-29
25655587-2	2015	Since the cytokine interleukin-2 (IL-2) is essential for the clonal expansion and differentiation of T lymphocytes, we investigated the effect of piperine on IL-2 signaling in IL-2-dependent mouse CTLL-2 T lymphocytes.	piperine	146-154	interleukin 2	Mus musculus	158-162
25655587-2	2015	Since the cytokine interleukin-2 (IL-2) is essential for the clonal expansion and differentiation of T lymphocytes, we investigated the effect of piperine on IL-2 signaling in IL-2-dependent mouse CTLL-2 T lymphocytes.	piperine	146-154	interleukin 2	Mus musculus	158-162
25655587-3	2015	Tritiated-thymidine incorporation assays and flow cytometric analysis of Oregon Green 488-stained cells showed that piperine inhibited IL-2-driven T lymphocyte proliferation; however, piperine did not cause T lymphocytes to die or decrease their expression of the high affinity IL-2 receptor, as determined by flow cytometry.	piperine	116-124	interleukin 2	Mus musculus	135-139
25655587-4	2015	Western blot analysis showed that piperine blocked the IL-2-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 and STAT5 without affecting the upstream phosphorylation of Janus kinase (JAK) 1 and JAK3.	piperine	34-42	interleukin 2	Mus musculus	55-59
25655587-4	2015	Western blot analysis showed that piperine blocked the IL-2-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 and STAT5 without affecting the upstream phosphorylation of Janus kinase (JAK) 1 and JAK3.	piperine	34-42	signal transducer and activator of transcription 3	Mus musculus	87-144
25655587-4	2015	Western blot analysis showed that piperine blocked the IL-2-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 and STAT5 without affecting the upstream phosphorylation of Janus kinase (JAK) 1 and JAK3.	piperine	34-42	signal transducer and activator of transcription 5A	Mus musculus	149-154
25655587-4	2015	Western blot analysis showed that piperine blocked the IL-2-induced phosphorylation of signal transducer and activator of transcription (STAT) 3 and STAT5 without affecting the upstream phosphorylation of Janus kinase (JAK) 1 and JAK3.	piperine	34-42	Janus kinase 3	Mus musculus	230-234
25655587-5	2015	In addition, piperine inhibited the IL-2-induced phosphorylation of extracellular signal-regulated kinase 1/2 and Akt, which are signaling molecules that regulate cell cycle progression.	piperine	13-21	interleukin 2	Mus musculus	36-40
25655587-5	2015	In addition, piperine inhibited the IL-2-induced phosphorylation of extracellular signal-regulated kinase 1/2 and Akt, which are signaling molecules that regulate cell cycle progression.	piperine	13-21	thymoma viral proto-oncogene 1	Mus musculus	68-117
25655587-6	2015	Piperine also suppressed the expression of cyclin-dependent kinase (Cdk) 1, Cdk4, Cdk6, cyclin B, cyclin D2, and Cdc25c protein phosphatase by IL-2-stimulated T lymphocytes, indicating G0/G1 and G2/M cell cycle arrest.	piperine	0-8	cyclin-dependent kinase 1	Mus musculus	43-74
25655587-6	2015	Piperine also suppressed the expression of cyclin-dependent kinase (Cdk) 1, Cdk4, Cdk6, cyclin B, cyclin D2, and Cdc25c protein phosphatase by IL-2-stimulated T lymphocytes, indicating G0/G1 and G2/M cell cycle arrest.	piperine	0-8	cyclin-dependent kinase 4	Mus musculus	76-80
25655587-6	2015	Piperine also suppressed the expression of cyclin-dependent kinase (Cdk) 1, Cdk4, Cdk6, cyclin B, cyclin D2, and Cdc25c protein phosphatase by IL-2-stimulated T lymphocytes, indicating G0/G1 and G2/M cell cycle arrest.	piperine	0-8	cyclin-dependent kinase 6	Mus musculus	82-86
25655587-6	2015	Piperine also suppressed the expression of cyclin-dependent kinase (Cdk) 1, Cdk4, Cdk6, cyclin B, cyclin D2, and Cdc25c protein phosphatase by IL-2-stimulated T lymphocytes, indicating G0/G1 and G2/M cell cycle arrest.	piperine	0-8	cyclin D2	Mus musculus	98-107
25655587-6	2015	Piperine also suppressed the expression of cyclin-dependent kinase (Cdk) 1, Cdk4, Cdk6, cyclin B, cyclin D2, and Cdc25c protein phosphatase by IL-2-stimulated T lymphocytes, indicating G0/G1 and G2/M cell cycle arrest.	piperine	0-8	cell division cycle 25C	Mus musculus	113-119
25655587-6	2015	Piperine also suppressed the expression of cyclin-dependent kinase (Cdk) 1, Cdk4, Cdk6, cyclin B, cyclin D2, and Cdc25c protein phosphatase by IL-2-stimulated T lymphocytes, indicating G0/G1 and G2/M cell cycle arrest.	piperine	0-8	interleukin 2	Mus musculus	143-147
25655587-7	2015	Piperine-mediated inhibition of IL-2 signaling and cell cycle progression in CTLL-2 T lymphocytes suggests that piperine should be further investigated in animal models as a possible natural source treatment for T lymphocyte-mediated transplant rejection and autoimmune disease.	piperine	0-8	interleukin 2	Mus musculus	32-36
25655587-7	2015	Piperine-mediated inhibition of IL-2 signaling and cell cycle progression in CTLL-2 T lymphocytes suggests that piperine should be further investigated in animal models as a possible natural source treatment for T lymphocyte-mediated transplant rejection and autoimmune disease.	piperine	112-120	interleukin 2	Mus musculus	32-36
25682002-6	2015	The docking results demonstrated that piperine has good binding affinity towards CD4 and CD8 receptors.	piperine	38-46	CD4 antigen	Mus musculus	81-84
25682002-8	2015	The early activated markers of apoptosis such as enhanced reactive oxygen species (ROS) and caspase-3 activation by DLM was significantly reduced by piperine treatment.	piperine	149-157	caspase 3	Mus musculus	92-101
25438036-0	2015	Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes.	piperine	11-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
25868812-3	2015	The docking results demonstrated that curcumin has good binding affinity towards CD28 and CD45 receptors as compared to piperine but in vitro studies revealed that piperine is more effective.	piperine	164-172	CD28 molecule	Homo sapiens	81-85
25444919-5	2015	In addition, G1- and G2-associated protein expression was decreased and p21(Waf1/Cip1) expression was increased in piperine-treated TNBC cells.	piperine	115-123	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	72-75
25444919-5	2015	In addition, G1- and G2-associated protein expression was decreased and p21(Waf1/Cip1) expression was increased in piperine-treated TNBC cells.	piperine	115-123	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	76-80
25444919-5	2015	In addition, G1- and G2-associated protein expression was decreased and p21(Waf1/Cip1) expression was increased in piperine-treated TNBC cells.	piperine	115-123	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	81-85
25444919-6	2015	Piperine also inhibited survival-promoting Akt activation in TNBC cells and caused caspase-dependent apoptosis via the mitochondrial pathway.	piperine	0-8	thymoma viral proto-oncogene 1	Mus musculus	43-46
25444919-8	2015	The in vitro migration of piperine-treated TNBC cells was impaired and expression of matrix metalloproteinase-2 and -9 mRNA was decreased, suggesting an antimetastatic effect by piperine.	piperine	178-186	matrix metallopeptidase 2	Mus musculus	85-118
25384161-6	2015	Our results showed that piperine significantly attenuated the proliferation of VSMCs by increasing the expression of p27(kip1), regulating the mRNA expression of cell cycle enzymes (cyclin D, cyclin E, and PCNA), and decreasing the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 in a noncytotoxic concentration-dependent manner (30-100 muM).	piperine	24-32	interferon alpha inducible protein 27	Homo sapiens	117-120
25384161-6	2015	Our results showed that piperine significantly attenuated the proliferation of VSMCs by increasing the expression of p27(kip1), regulating the mRNA expression of cell cycle enzymes (cyclin D, cyclin E, and PCNA), and decreasing the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 in a noncytotoxic concentration-dependent manner (30-100 muM).	piperine	24-32	cyclin dependent kinase inhibitor 1B	Homo sapiens	121-125
25384161-6	2015	Our results showed that piperine significantly attenuated the proliferation of VSMCs by increasing the expression of p27(kip1), regulating the mRNA expression of cell cycle enzymes (cyclin D, cyclin E, and PCNA), and decreasing the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 in a noncytotoxic concentration-dependent manner (30-100 muM).	piperine	24-32	proliferating cell nuclear antigen	Homo sapiens	206-210
25384161-6	2015	Our results showed that piperine significantly attenuated the proliferation of VSMCs by increasing the expression of p27(kip1), regulating the mRNA expression of cell cycle enzymes (cyclin D, cyclin E, and PCNA), and decreasing the phosphorylation of extracellular signal-regulated kinase (ERK)1/2 in a noncytotoxic concentration-dependent manner (30-100 muM).	piperine	24-32	mitogen-activated protein kinase 1	Homo sapiens	251-297
25384161-8	2015	Our results showed that 100 muM piperine decreased cell migration, the production of reactive oxygen species (ROS), and phosphorylation of the p38 mitogen-activated protein kinase (MAPK).	piperine	32-40	mitogen-activated protein kinase 14	Homo sapiens	143-179
25384161-8	2015	Our results showed that 100 muM piperine decreased cell migration, the production of reactive oxygen species (ROS), and phosphorylation of the p38 mitogen-activated protein kinase (MAPK).	piperine	32-40	mitogen-activated protein kinase 3	Homo sapiens	181-185
25384161-9	2015	Taken together, our results suggest that piperine inhibits PDGF-BB-induced proliferation and the migration of VSMCs by inducing cell cycle arrest and suppressing MAPK phosphorylation and ROS.	piperine	41-49	mitogen-activated protein kinase 3	Homo sapiens	162-166
25438036-0	2015	Developing piperine towards TRPV1 and GABAA receptor ligands--synthesis of piperine analogs via Heck-coupling of conjugated dienes.	piperine	75-83	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
25054206-0	2015	Cytotoxicity and comparative binding mechanism of piperine with human serum albumin and alpha-1-acid glycoprotein.	piperine	50-58	albumin	Mus musculus	76-83
25471891-0	2015	Piperine Suppresses the Expression of CXCL8 in Lipopolysaccharide-Activated SW480 and HT-29 Cells via Downregulating the Mitogen-Activated Protein Kinase Pathways.	piperine	0-8	C-X-C motif chemokine ligand 8	Homo sapiens	38-43
25471891-5	2015	Importantly, piperine dose-dependently suppressed LPS-induced secretion of CXCL8 and the expression of CXCL8 messenger RNA (mRNA).	piperine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	75-80
25471891-5	2015	Importantly, piperine dose-dependently suppressed LPS-induced secretion of CXCL8 and the expression of CXCL8 messenger RNA (mRNA).	piperine	13-21	C-X-C motif chemokine ligand 8	Homo sapiens	103-108
25471891-6	2015	Although piperine failed to affect the critical inflammatory nuclear factor-kappaB pathway, it attenuated the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signaling.	piperine	9-17	mitogen-activated protein kinase 8	Homo sapiens	110-133
25471891-6	2015	Although piperine failed to affect the critical inflammatory nuclear factor-kappaB pathway, it attenuated the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signaling.	piperine	9-17	mitogen-activated protein kinase 8	Homo sapiens	135-138
25471891-6	2015	Although piperine failed to affect the critical inflammatory nuclear factor-kappaB pathway, it attenuated the c-Jun N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (MAPK) signaling.	piperine	9-17	mitogen-activated protein kinase 14	Homo sapiens	144-147
25471891-8	2015	Collectively, our results indicated that piperine could attenuate the inflammatory response in epithelial cells via downregulating the MAPK signaling and thus the expression of CXCL8, suggesting its potential application in anti-inflammation therapy.	piperine	41-49	C-X-C motif chemokine ligand 8	Homo sapiens	177-182
25054206-3	2015	Further, the fluorescence maximum quenching of proteins were observed upon binding of piperine to HSA and AGP through a static quenching mechanism.	piperine	86-94	CD24a antigen	Mus musculus	98-101
25054206-4	2015	The binding constants obtained from fluorescence emission were found to be K(piperine) = 5.7 +- .2 x 10(5) M(-1) and K(piperine) = 9.3+- .25 x 10(4) M(-1) which correspond to the free energy of -7.8 and -6.71 kcal M(-1)at 25  C for HSA and AGP, respectively.	piperine	77-85	CD24a antigen	Mus musculus	232-235
25054206-4	2015	The binding constants obtained from fluorescence emission were found to be K(piperine) = 5.7 +- .2 x 10(5) M(-1) and K(piperine) = 9.3+- .25 x 10(4) M(-1) which correspond to the free energy of -7.8 and -6.71 kcal M(-1)at 25  C for HSA and AGP, respectively.	piperine	119-127	CD24a antigen	Mus musculus	232-235
25054206-6	2015	Consequently, inference drawn from the site-specific markers (phenylbutazone, site I marker) studies to identify the binding site of HSA noticed that piperine binds at site I (IIA), which was further authenticated by molecular docking and molecular dynamic (MD) studies.	piperine	150-158	CD24a antigen	Mus musculus	133-136
25054206-6	2015	Consequently, inference drawn from the site-specific markers (phenylbutazone, site I marker) studies to identify the binding site of HSA noticed that piperine binds at site I (IIA), which was further authenticated by molecular docking and molecular dynamic (MD) studies.	piperine	150-158	ATPase, class II, type 9A	Mus musculus	176-179
25054206-7	2015	The binding constants and free energy corresponding to experimental and computational analysis suggest that there are hydrophobic and hydrophilic interactions when piperine binds to HSA.	piperine	164-172	CD24a antigen	Mus musculus	182-185
26160506-1	2015	Piperine (P), a sensory stimulant in black pepper, is an agonist on TRPV1 receptors.	piperine	0-8	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	68-73
25479727-0	2015	Piperine inhibits proliferation of human osteosarcoma cells via G2/M phase arrest and metastasis by suppressing MMP-2/-9 expression.	piperine	0-8	matrix metallopeptidase 2	Homo sapiens	112-120
25479727-4	2015	Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2).	piperine	0-8	cyclin B1	Homo sapiens	131-140
25479727-4	2015	Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2).	piperine	0-8	cyclin dependent kinase 1	Homo sapiens	174-199
25479727-4	2015	Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2).	piperine	0-8	cyclin dependent kinase 1	Homo sapiens	200-204
25479727-4	2015	Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2).	piperine	0-8	checkpoint kinase 2	Homo sapiens	210-229
25479727-4	2015	Piperine inhibited osteosarcoma cell proliferation by causing G2/M phase cell cycle arrest associated with decreased expression of cyclin B1 and increased phosphorylation of Cyclin-dependent kinase-1(CDK1) and checkpoint kinase 2 (Chk2).	piperine	0-8	checkpoint kinase 2	Homo sapiens	231-235
25479727-5	2015	In addition, piperine treatment inhibited phosphorylation of Akt and activated phosphorylation of c-Jun N-terminal kinase (c-JNK) and p38 mitogen-activated protein kinase (MAPK) in HOS and U2OS cells.	piperine	13-21	AKT serine/threonine kinase 1	Homo sapiens	61-64
25479727-5	2015	In addition, piperine treatment inhibited phosphorylation of Akt and activated phosphorylation of c-Jun N-terminal kinase (c-JNK) and p38 mitogen-activated protein kinase (MAPK) in HOS and U2OS cells.	piperine	13-21	mitogen-activated protein kinase 14	Homo sapiens	134-170
25479727-8	2015	Moreover, gelatin zymography showed that piperine inhibited the activity of matrix metalloproteinase (MMP)-2/-9 and increased the expression of tissue inhibitor of metalloproteinase (TIMP)-1/-2.	piperine	41-49	matrix metallopeptidase 2	Homo sapiens	76-108
25479727-8	2015	Moreover, gelatin zymography showed that piperine inhibited the activity of matrix metalloproteinase (MMP)-2/-9 and increased the expression of tissue inhibitor of metalloproteinase (TIMP)-1/-2.	piperine	41-49	TIMP metallopeptidase inhibitor 1	Homo sapiens	144-190
25479727-9	2015	Taken together, our results indicate that piperine inhibits proliferation, by inducing G2/M cell cycle arrest, and the migration and invasion of HOS and U2OS cells, via increased expression of TIMP-1/-2 and down-regulation of MMP-2/-9.	piperine	42-50	TIMP metallopeptidase inhibitor 1	Homo sapiens	193-202
25479727-9	2015	Taken together, our results indicate that piperine inhibits proliferation, by inducing G2/M cell cycle arrest, and the migration and invasion of HOS and U2OS cells, via increased expression of TIMP-1/-2 and down-regulation of MMP-2/-9.	piperine	42-50	matrix metallopeptidase 2	Homo sapiens	226-234
26598901-9	2015	Piperine addition to diets diminished visceral fats and increased the uncoupling protein 1 (UCP1) in interscapular brown adipose tissue (IBAT), and black pepper extract showed stronger effects than piperine.	piperine	0-8	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	70-90
26598901-9	2015	Piperine addition to diets diminished visceral fats and increased the uncoupling protein 1 (UCP1) in interscapular brown adipose tissue (IBAT), and black pepper extract showed stronger effects than piperine.	piperine	0-8	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	92-96
25234193-0	2015	Piperine inhibits IL-1beta-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells.	piperine	0-8	interleukin 1 beta	Homo sapiens	18-26
25234193-0	2015	Piperine inhibits IL-1beta-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells.	piperine	0-8	interleukin 6	Homo sapiens	35-39
25234193-0	2015	Piperine inhibits IL-1beta-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	66-69
25234193-0	2015	Piperine inhibits IL-1beta-induced IL-6 expression by suppressing p38 MAPK and STAT3 activation in gastric cancer cells.	piperine	0-8	signal transducer and activator of transcription 3	Homo sapiens	79-84
25234193-3	2015	However, the effects of piperine on IL-6 expression in gastric cancer cells have not yet been well defined.	piperine	24-32	interleukin 6	Homo sapiens	36-40
25234193-5	2015	Our results showed that piperine inhibited interleukin-1beta (IL-1beta)-induced IL-6 expression in a dose-dependent manner.	piperine	24-32	interleukin 1 beta	Homo sapiens	43-60
25234193-5	2015	Our results showed that piperine inhibited interleukin-1beta (IL-1beta)-induced IL-6 expression in a dose-dependent manner.	piperine	24-32	interleukin 1 beta	Homo sapiens	62-70
25234193-5	2015	Our results showed that piperine inhibited interleukin-1beta (IL-1beta)-induced IL-6 expression in a dose-dependent manner.	piperine	24-32	interleukin 6	Homo sapiens	80-84
25234193-6	2015	In addition, piperine also inhibited IL-6 promoter activity.	piperine	13-21	interleukin 6	Homo sapiens	37-41
25234193-9	2015	Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression.	piperine	0-8	interleukin 1 beta	Homo sapiens	19-27
25234193-9	2015	Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	36-39
25234193-9	2015	Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression.	piperine	0-8	signal transducer and activator of transcription 3	Homo sapiens	49-54
25234193-9	2015	Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression.	piperine	0-8	interleukin 1 beta	Homo sapiens	92-100
25234193-9	2015	Piperine inhibited IL-1beta-induced p38 MAPK and STAT3 activation and, in turn, blocked the IL-1beta-induced IL-6 expression.	piperine	0-8	interleukin 6	Homo sapiens	109-113
25234193-10	2015	Furthermore, gastric cancer cells pretreated with IL-1beta showed markedly enhanced invasiveness, which was partially abrogated by treatment with IL-6 siRNA, piperine, and inhibitors of p38 MAPK and STAT3.	piperine	158-166	interleukin 1 beta	Homo sapiens	50-58
25234193-11	2015	These results suggest that piperine may exert at least part of its anti-cancer effect by controlling IL-6 expression through the suppression of p38 MAPK and STAT3.	piperine	27-35	interleukin 6	Homo sapiens	101-105
25234193-11	2015	These results suggest that piperine may exert at least part of its anti-cancer effect by controlling IL-6 expression through the suppression of p38 MAPK and STAT3.	piperine	27-35	mitogen-activated protein kinase 14	Homo sapiens	144-147
25234193-11	2015	These results suggest that piperine may exert at least part of its anti-cancer effect by controlling IL-6 expression through the suppression of p38 MAPK and STAT3.	piperine	27-35	signal transducer and activator of transcription 3	Homo sapiens	157-162
25868617-0	2015	Antiallergic effect of piperine on ovalbumin-induced allergic rhinitis in mice.	piperine	23-31	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	35-44
25868617-14	2015	PIP dose dependently reduced histamine, NO concentration (p &lt; 0.001), as well as reduced expression of IL-6, IL-1beta, and IgE (p &lt; 0.001) as compared with the control group.	piperine	0-3	interleukin 6	Mus musculus	106-110
25868617-14	2015	PIP dose dependently reduced histamine, NO concentration (p &lt; 0.001), as well as reduced expression of IL-6, IL-1beta, and IgE (p &lt; 0.001) as compared with the control group.	piperine	0-3	interleukin 1 beta	Mus musculus	112-120
26146123-9	2015	Piperine demonstrated inhibition of monoamine oxidase enzymes, elevation of brain 5-HT and BDNF levels, and modulation of the hypothalamus-pituitary-adrenal axis.	piperine	0-8	brain derived neurotrophic factor	Homo sapiens	91-95
25307563-0	2014	The inhibitory effect of piperine from Fructus piperis extract on the degranulation of RBL-2H3 cells.	piperine	25-33	RB transcriptional corepressor like 2	Rattus norvegicus	87-92
25307563-6	2014	Here, the rat basophilic leukemia cells by membrane chromatography (RBL-2H3/CMC) coupled to high performance liquid chromatography/mass spectrometry (HPLC/MS) to discover and identify piperine can bind to RBL-2H3 cell membranes.	piperine	184-192	RB transcriptional corepressor like 2	Rattus norvegicus	68-73
25307563-7	2014	Piperine inhibited the expression of cytokines, and the release of both beta-hexosaminidase and histamine, which could be stimulated by antigen in RBL-2H3 mast cells.	piperine	0-8	O-GlcNAcase	Rattus norvegicus	72-91
25307563-9	2014	Furthermore, RT-PCR showed that the mRNA expression levels of IL-4, IL-13, and TNF-alpha were significantly suppressed by piperine.	piperine	122-130	interleukin 4	Rattus norvegicus	62-66
25307563-9	2014	Furthermore, RT-PCR showed that the mRNA expression levels of IL-4, IL-13, and TNF-alpha were significantly suppressed by piperine.	piperine	122-130	interleukin 13	Rattus norvegicus	68-73
25307563-9	2014	Furthermore, RT-PCR showed that the mRNA expression levels of IL-4, IL-13, and TNF-alpha were significantly suppressed by piperine.	piperine	122-130	tumor necrosis factor	Rattus norvegicus	79-88
25307563-10	2014	The inhibitory effect of piperine on IgE-mediated degranulation and cytokine production by RBL-2H3 cells may be caused by the inhibition of IgE-mediated signaling pathways, including the phosphorylation of Lyn, p38, Erk, and Ras.	piperine	25-33	mitogen activated protein kinase 14	Rattus norvegicus	211-214
25307563-10	2014	The inhibitory effect of piperine on IgE-mediated degranulation and cytokine production by RBL-2H3 cells may be caused by the inhibition of IgE-mediated signaling pathways, including the phosphorylation of Lyn, p38, Erk, and Ras.	piperine	25-33	Eph receptor B1	Rattus norvegicus	216-219
25153972-0	2014	Piperine inhibits the activities of platelet cytosolic phospholipase A2 and thromboxane A2 synthase without affecting cyclooxygenase-1 activity: different mechanisms of action are involved in the inhibition of platelet aggregation and macrophage inflammatory response.	piperine	0-8	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	45-71
24326980-3	2014	The aim of this study was to explore the effect of piperine, a dual TRPV1/TRPA1 agonist, on the swallow response of dysphagic patients.	piperine	51-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
24326980-3	2014	The aim of this study was to explore the effect of piperine, a dual TRPV1/TRPA1 agonist, on the swallow response of dysphagic patients.	piperine	51-59	transient receptor potential cation channel subfamily A member 1	Homo sapiens	74-79
25685661-6	2015	Piperine also decreased the phosphorylation of CREB, which is up-regulated by eugenol.	piperine	0-8	cAMP responsive element binding protein 1	Mus musculus	47-51
25685661-7	2015	These results suggest that piperine inhibits the eugenol-induced signal transduction pathway through modulation of cAMP and calcium levels and phosphorylation of CREB in non-chemosensory cells.	piperine	27-35	cAMP responsive element binding protein 1	Mus musculus	162-166
25149996-10	2014	Pre-treatment with aminoguanidine (50mg/kg, ip), an inducible nitric oxide synthase (NOS) inhibitor, significantly potentiated the anxiolytic-like activity of piperine, as compared to piperine and aminoguanidine alone in stressed mice.	piperine	159-167	nitric oxide synthase 1, neuronal	Mus musculus	62-83
25153972-5	2014	These results suggest that piperine inhibits platelet aggregation by attenuating cPLA2 and TXA2 synthase activities, rather than through the inhibition of COX-1 activity.	piperine	27-35	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	81-86
25153972-6	2014	On the other hand, piperine significantly inhibited lipopolysaccharide-induced generation of prostaglandin (PG)E2 and PGD2 in RAW264.7 cells by suppressing the activity of COX-2, without effect on cPLA2; CONCLUSION: Our findings indicate that piperine inhibits platelet aggregation and macrophage inflammatory response by different mechanisms.	piperine	19-27	prostaglandin D2 synthase (brain)	Mus musculus	118-122
25153972-6	2014	On the other hand, piperine significantly inhibited lipopolysaccharide-induced generation of prostaglandin (PG)E2 and PGD2 in RAW264.7 cells by suppressing the activity of COX-2, without effect on cPLA2; CONCLUSION: Our findings indicate that piperine inhibits platelet aggregation and macrophage inflammatory response by different mechanisms.	piperine	19-27	cytochrome c oxidase II, mitochondrial	Mus musculus	172-177
25153972-6	2014	On the other hand, piperine significantly inhibited lipopolysaccharide-induced generation of prostaglandin (PG)E2 and PGD2 in RAW264.7 cells by suppressing the activity of COX-2, without effect on cPLA2; CONCLUSION: Our findings indicate that piperine inhibits platelet aggregation and macrophage inflammatory response by different mechanisms.	piperine	19-27	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	197-202
24671493-5	2014	Pretreatment of RBL-2H3 cells with piperine inhibited IgE-induced activation of type II PtdIns 4-kinase(s).	piperine	35-43	RB transcriptional corepressor like 2	Rattus norvegicus	16-21
24671493-7	2014	Concomitantly, pretreatment of RBL-2H3 cells with piperine also inhibited IgE-induced beta-hexosaminidase release in RBL-2H3 cells.	piperine	50-58	RB transcriptional corepressor like 2	Rattus norvegicus	31-36
24671493-7	2014	Concomitantly, pretreatment of RBL-2H3 cells with piperine also inhibited IgE-induced beta-hexosaminidase release in RBL-2H3 cells.	piperine	50-58	O-GlcNAcase	Rattus norvegicus	86-105
24671493-7	2014	Concomitantly, pretreatment of RBL-2H3 cells with piperine also inhibited IgE-induced beta-hexosaminidase release in RBL-2H3 cells.	piperine	50-58	RB transcriptional corepressor like 2	Rattus norvegicus	117-122
24905252-0	2014	Efficient modulation of gamma-aminobutyric acid type A receptors by piperine derivatives.	piperine	68-76	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	24-64
24905252-1	2014	Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates gamma-aminobutyric acid type A receptors (GABAAR).	piperine	0-8	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
24905252-1	2014	Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates gamma-aminobutyric acid type A receptors (GABAAR).	piperine	0-8	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	26-80
24905252-1	2014	Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates gamma-aminobutyric acid type A receptors (GABAAR).	piperine	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	106-146
24905252-1	2014	Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates gamma-aminobutyric acid type A receptors (GABAAR).	piperine	0-8	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	148-154
24905252-2	2014	We have synthesized a library of 76 piperine analogues and analyzed their effects on GABAAR by means of a two-microelectrode voltage-clamp technique.	piperine	36-44	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	85-91
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	apolipoprotein A1	Rattus norvegicus	180-197
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	apolipoprotein A1	Rattus norvegicus	199-204
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	low density lipoprotein receptor	Rattus norvegicus	330-334
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	lecithin cholesterol acyltransferase	Rattus norvegicus	207-243
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	piperine	79-87	apolipoprotein A1	Rattus norvegicus	194-199
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	lecithin cholesterol acyltransferase	Rattus norvegicus	245-249
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	piperine	79-87	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	201-207
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	252-282
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	piperine	79-87	lecithin cholesterol acyltransferase	Rattus norvegicus	209-213
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	284-290
24944632-6	2014	In conclusion, these results indicated that co-administration of curcumin plus piperine potentiates the hypocholesterolemic effects of curcumin by increasing the activity and gene expression of ApoAI, CYP7A1, LCAT and LDLR, providing a promising combination for the treatment of HLP.	piperine	79-87	low density lipoprotein receptor	Rattus norvegicus	218-222
24944632-5	2014	Furthermore, compared with administration of curcumin alone, administration of curcumin plus piperine resulted in a significant upregulation of the activity and gene expression of apolipoprotein AI (ApoAI), lecithin cholesterol acyltransferase (LCAT), cholesterol 7alpha-hydroxylase (CYP7A1) and low-density lipoprotein receptor (LDLR).	piperine	93-101	low density lipoprotein receptor	Rattus norvegicus	296-328
24816193-0	2014	Piperine reverses the effects of corticosterone on behavior and hippocampal BDNF expression in mice.	piperine	0-8	brain derived neurotrophic factor	Mus musculus	76-80
24816193-8	2014	The results suggest that piperine produces an antidepressant-like effect in corticosterone-treated mice, which is possibly mediated by increasing brain-derived neurotrophic factor expression in the hippocampus.	piperine	25-33	brain derived neurotrophic factor	Mus musculus	146-179
24786847-4	2014	A significant increase in the Peff when co-perfused with verapamil or piperine indicated that piperine effectively inhibited P-glycoprotein mediated efflux of linarin.	piperine	70-78	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	125-139
24880706-9	2014	The up-regulation of Th1 immunity by piperine can be synergistically combined with rifampicin to improve its therapeutic efficacy in immune-compromised TB patients.	piperine	37-45	negative elongation factor complex member C/D	Homo sapiens	21-24
24804719-0	2014	Piperine causes G1 phase cell cycle arrest and apoptosis in melanoma cells through checkpoint kinase-1 activation.	piperine	0-8	checkpoint kinase 1	Homo sapiens	83-102
24804719-4	2014	The G1 arrest by piperine correlated with the down-regulation of cyclin D1 and induction of p21.	piperine	17-25	cyclin D1	Homo sapiens	65-74
24804719-4	2014	The G1 arrest by piperine correlated with the down-regulation of cyclin D1 and induction of p21.	piperine	17-25	H3 histone pseudogene 16	Homo sapiens	92-95
24804719-5	2014	Furthermore, this growth arrest by piperine treatment was associated with DNA damage as indicated by phosphorylation of H2AX at Ser139, activation of ataxia telangiectasia and rad3-related protein (ATR) and checkpoint kinase 1 (Chk1).	piperine	35-43	H2A.X variant histone	Homo sapiens	120-124
24804719-5	2014	Furthermore, this growth arrest by piperine treatment was associated with DNA damage as indicated by phosphorylation of H2AX at Ser139, activation of ataxia telangiectasia and rad3-related protein (ATR) and checkpoint kinase 1 (Chk1).	piperine	35-43	ATR serine/threonine kinase	Homo sapiens	150-196
24804719-5	2014	Furthermore, this growth arrest by piperine treatment was associated with DNA damage as indicated by phosphorylation of H2AX at Ser139, activation of ataxia telangiectasia and rad3-related protein (ATR) and checkpoint kinase 1 (Chk1).	piperine	35-43	ATR serine/threonine kinase	Homo sapiens	198-201
24804719-5	2014	Furthermore, this growth arrest by piperine treatment was associated with DNA damage as indicated by phosphorylation of H2AX at Ser139, activation of ataxia telangiectasia and rad3-related protein (ATR) and checkpoint kinase 1 (Chk1).	piperine	35-43	checkpoint kinase 1	Homo sapiens	207-226
24804719-5	2014	Furthermore, this growth arrest by piperine treatment was associated with DNA damage as indicated by phosphorylation of H2AX at Ser139, activation of ataxia telangiectasia and rad3-related protein (ATR) and checkpoint kinase 1 (Chk1).	piperine	35-43	checkpoint kinase 1	Homo sapiens	228-232
24804719-6	2014	Pretreatment with AZD 7762, a Chk1 inhibitor not only abrogated the activation of Chk1 but also piperine mediated G1 arrest.	piperine	96-104	checkpoint kinase 1	Homo sapiens	30-34
24804719-7	2014	Similarly, transfection of cells with Chk1 siRNA completely protected the cells from G1 arrest induced by piperine.	piperine	106-114	checkpoint kinase 1	Homo sapiens	38-42
24804719-8	2014	Piperine treatment caused down-regulation of E2F1 and phosphorylation of retinoblastoma protein (Rb).	piperine	0-8	E2F transcription factor 1	Homo sapiens	45-49
24804719-9	2014	Apoptosis induced by piperine was associated with down-regulation of XIAP, Bid (full length) and cleavage of Caspase-3 and PARP.	piperine	21-29	X-linked inhibitor of apoptosis	Homo sapiens	69-73
24804719-9	2014	Apoptosis induced by piperine was associated with down-regulation of XIAP, Bid (full length) and cleavage of Caspase-3 and PARP.	piperine	21-29	BH3 interacting domain death agonist	Homo sapiens	75-78
24804719-9	2014	Apoptosis induced by piperine was associated with down-regulation of XIAP, Bid (full length) and cleavage of Caspase-3 and PARP.	piperine	21-29	caspase 3	Homo sapiens	109-118
24804719-9	2014	Apoptosis induced by piperine was associated with down-regulation of XIAP, Bid (full length) and cleavage of Caspase-3 and PARP.	piperine	21-29	poly(ADP-ribose) polymerase 1	Homo sapiens	123-127
24804719-12	2014	These results suggest that piperine mediated ROS played a critical role in inducing DNA damage and activation of Chk1 leading to G1 cell cycle arrest and apoptosis.	piperine	27-35	checkpoint kinase 1	Homo sapiens	113-117
24786847-4	2014	A significant increase in the Peff when co-perfused with verapamil or piperine indicated that piperine effectively inhibited P-glycoprotein mediated efflux of linarin.	piperine	94-102	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	125-139
24786847-6	2014	The results showed that piperine increased the plasma exposure (AUC) of linarin by 381% along with an increase in the Cmax by 346% and the Tmax from 0.05 h to 0.2 h. The present study revealed that piperine significantly enhanced the oral absorption of linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of linarin.	piperine	24-32	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	283-297
24786847-6	2014	The results showed that piperine increased the plasma exposure (AUC) of linarin by 381% along with an increase in the Cmax by 346% and the Tmax from 0.05 h to 0.2 h. The present study revealed that piperine significantly enhanced the oral absorption of linarin in rats by inhibiting P-glycoprotein mediated cellular efflux during the intestinal absorption and likely simultaneously by inhibiting the metabolism of linarin.	piperine	198-206	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	283-297
24688365-9	2014	CONCLUSION: TRPV1 receptor is successfully stimulated by capsaicin, piperine, and natural capsaicinoids.	piperine	68-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
24272201-0	2014	Piperine induces apoptosis of lung cancer A549 cells via p53-dependent mitochondrial signaling pathway.	piperine	0-8	tumor protein p53	Homo sapiens	57-60
24272201-4	2014	Besides, piperine had the ability to cause cell cycle arrest in G2/M phase and to activate caspase-3 and caspase-9 cascades in A549 cells.	piperine	9-17	caspase 3	Homo sapiens	91-100
24272201-4	2014	Besides, piperine had the ability to cause cell cycle arrest in G2/M phase and to activate caspase-3 and caspase-9 cascades in A549 cells.	piperine	9-17	caspase 9	Homo sapiens	105-114
24272201-6	2014	In addition, piperine treatment decreased Bcl-2 protein expression, but increased Bax protein expression in A549 cells, which were positively correlated with an elevated expression of p53 compared to control.	piperine	13-21	BCL2 apoptosis regulator	Homo sapiens	42-47
24272201-6	2014	In addition, piperine treatment decreased Bcl-2 protein expression, but increased Bax protein expression in A549 cells, which were positively correlated with an elevated expression of p53 compared to control.	piperine	13-21	BCL2 associated X, apoptosis regulator	Homo sapiens	82-85
24272201-6	2014	In addition, piperine treatment decreased Bcl-2 protein expression, but increased Bax protein expression in A549 cells, which were positively correlated with an elevated expression of p53 compared to control.	piperine	13-21	tumor protein p53	Homo sapiens	184-187
24272201-7	2014	Taken together, these results suggested that piperine could induce p53-mediated cell cycle arrest and apoptosis via activation of caspase-3 and caspase-9 cascades, as well as increasing the Bax/Bcl-2 ratio.	piperine	45-53	tumor protein p53	Homo sapiens	67-70
24361910-0	2014	Brain-derived neurotrophic factor signalling mediates the antidepressant-like effect of piperine in chronically stressed mice.	piperine	88-96	brain derived neurotrophic factor	Mus musculus	0-33
24361910-2	2014	This study aimed to investigate the role of brain-derived neurotrophic factor (BDNF) signalling in the antidepressant-like effect of piperine in mice exposed to chronic unpredictable mild stress (CUMS).	piperine	133-141	brain derived neurotrophic factor	Mus musculus	44-77
24361910-2	2014	This study aimed to investigate the role of brain-derived neurotrophic factor (BDNF) signalling in the antidepressant-like effect of piperine in mice exposed to chronic unpredictable mild stress (CUMS).	piperine	133-141	brain derived neurotrophic factor	Mus musculus	79-83
24361910-7	2014	In parallel, chronic piperine treatment significantly increased BDNF protein expression in the hippocampus and frontal cortex of both naive and CUMS-treated mice.	piperine	21-29	brain derived neurotrophic factor	Mus musculus	64-68
24361910-8	2014	In addition, inhibition of BDNF signalling by injection of K252a, an inhibitor of the BDNF receptor TrkB, significantly blocked the antidepressant-like effect of piperine in the sucrose preference test and forced swim test of CUMS-treated mice.	piperine	162-170	brain derived neurotrophic factor	Mus musculus	27-31
24361910-8	2014	In addition, inhibition of BDNF signalling by injection of K252a, an inhibitor of the BDNF receptor TrkB, significantly blocked the antidepressant-like effect of piperine in the sucrose preference test and forced swim test of CUMS-treated mice.	piperine	162-170	brain derived neurotrophic factor	Mus musculus	86-90
24361910-8	2014	In addition, inhibition of BDNF signalling by injection of K252a, an inhibitor of the BDNF receptor TrkB, significantly blocked the antidepressant-like effect of piperine in the sucrose preference test and forced swim test of CUMS-treated mice.	piperine	162-170	neurotrophic tyrosine kinase, receptor, type 2	Mus musculus	100-104
24361910-9	2014	Taken together, this study suggests that BDNF signalling is an essential mediator for the antidepressant-like effect of piperine.	piperine	120-128	brain derived neurotrophic factor	Mus musculus	41-45
24692724-0	2014	Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells.	piperine	0-8	TNF superfamily member 10	Homo sapiens	34-39
24692724-6	2014	RESULTS: After screening, we identified piperine as the most potent adjuvant at enhancing the efficacy of TRAIL-based therapies in TNBC cells in vitro and in vivo, which might be mediated through inhibition of survivin and p65 phosphorylation.	piperine	40-48	TNF superfamily member 10	Homo sapiens	106-111
24692724-6	2014	RESULTS: After screening, we identified piperine as the most potent adjuvant at enhancing the efficacy of TRAIL-based therapies in TNBC cells in vitro and in vivo, which might be mediated through inhibition of survivin and p65 phosphorylation.	piperine	40-48	RELA proto-oncogene, NF-kB subunit	Homo sapiens	223-226
24692724-7	2014	CONCLUSION: Piperine may enhance TRAIL-based therapeutics for TNBC.	piperine	12-20	TNF superfamily member 10	Homo sapiens	33-38
24401942-6	2014	The results suggest that piperine produces an antidepressant-like effect in CUMS-treated rats, which is possibly mediated by increasing 5-HT and BDNF contents in selective brain tissues.	piperine	25-33	brain-derived neurotrophic factor	Rattus norvegicus	145-149
24272201-7	2014	Taken together, these results suggested that piperine could induce p53-mediated cell cycle arrest and apoptosis via activation of caspase-3 and caspase-9 cascades, as well as increasing the Bax/Bcl-2 ratio.	piperine	45-53	caspase 3	Homo sapiens	130-139
24272201-7	2014	Taken together, these results suggested that piperine could induce p53-mediated cell cycle arrest and apoptosis via activation of caspase-3 and caspase-9 cascades, as well as increasing the Bax/Bcl-2 ratio.	piperine	45-53	caspase 9	Homo sapiens	144-153
24272201-7	2014	Taken together, these results suggested that piperine could induce p53-mediated cell cycle arrest and apoptosis via activation of caspase-3 and caspase-9 cascades, as well as increasing the Bax/Bcl-2 ratio.	piperine	45-53	BCL2 associated X, apoptosis regulator	Homo sapiens	190-193
24272201-7	2014	Taken together, these results suggested that piperine could induce p53-mediated cell cycle arrest and apoptosis via activation of caspase-3 and caspase-9 cascades, as well as increasing the Bax/Bcl-2 ratio.	piperine	45-53	BCL2 apoptosis regulator	Homo sapiens	194-199
23993530-2	2013	Administration of piperine (50 mg/kg body weight) to mice with HFD-induced hepatic steatosis resulted in a significant increase in plasma adiponectin levels.	piperine	18-26	adiponectin, C1Q and collagen domain containing	Mus musculus	138-149
24398010-0	2014	The effect of piperine on midazolam plasma concentration in healthy volunteers, a research on the CYP3A-involving metabolism.	piperine	14-22	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	98-103
23993530-7	2013	Piperine significantly decreased the phosphorylation of insulin receptor substrate-1 (IRS-1) compared with the HFD-fed mice.	piperine	0-8	insulin receptor substrate 1	Mus musculus	56-84
23993530-7	2013	Piperine significantly decreased the phosphorylation of insulin receptor substrate-1 (IRS-1) compared with the HFD-fed mice.	piperine	0-8	insulin receptor substrate 1	Mus musculus	86-91
23993530-8	2013	Administration of piperine appeared to reverse preexisting HFD-induced hepatic steatosis and insulin resistance, probably by activation of adiponectin-AMPK signalling in mice.	piperine	18-26	adiponectin, C1Q and collagen domain containing	Mus musculus	139-150
23870999-0	2013	Antitumor efficacy of piperine in the treatment of human HER2-overexpressing breast cancer cells.	piperine	22-30	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-61
23870999-2	2013	Here, the molecular mechanisms by which piperine exerts antitumor effects in HER2-overexpressing breast cancer cells was investigated.	piperine	40-48	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
23870999-3	2013	The results showed that piperine strongly inhibited proliferation and induced apoptosis through caspase-3 activation and PARP cleavage.	piperine	24-32	caspase 3	Homo sapiens	96-105
23870999-3	2013	The results showed that piperine strongly inhibited proliferation and induced apoptosis through caspase-3 activation and PARP cleavage.	piperine	24-32	collagen type XI alpha 2 chain	Homo sapiens	121-125
24689235-0	2013	[Effect of piperine on 5-HT and synaptophysin expression of rats with irritable bowel syndrome].	piperine	11-19	synaptophysin	Rattus norvegicus	32-45
23870999-4	2013	Furthermore, piperine inhibited HER2 gene expression at the transcriptional level.	piperine	13-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-36
23870999-5	2013	Blockade of ERK1/2 signaling by piperine significantly reduced SREBP-1 and FAS expression.	piperine	32-40	mitogen-activated protein kinase 3	Homo sapiens	12-18
23870999-5	2013	Blockade of ERK1/2 signaling by piperine significantly reduced SREBP-1 and FAS expression.	piperine	32-40	sterol regulatory element binding transcription factor 1	Homo sapiens	63-70
23870999-6	2013	Piperine strongly suppressed EGF-induced MMP-9 expression through inhibition of AP-1 and NF-kappaB activation by interfering with ERK1/2, p38 MAPK, and Akt signaling pathways resulting in a reduction in migration.	piperine	0-8	matrix metallopeptidase 9	Homo sapiens	41-46
23870999-6	2013	Piperine strongly suppressed EGF-induced MMP-9 expression through inhibition of AP-1 and NF-kappaB activation by interfering with ERK1/2, p38 MAPK, and Akt signaling pathways resulting in a reduction in migration.	piperine	0-8	mitogen-activated protein kinase 3	Homo sapiens	130-136
23870999-6	2013	Piperine strongly suppressed EGF-induced MMP-9 expression through inhibition of AP-1 and NF-kappaB activation by interfering with ERK1/2, p38 MAPK, and Akt signaling pathways resulting in a reduction in migration.	piperine	0-8	AKT serine/threonine kinase 1	Homo sapiens	152-155
23870999-7	2013	Finally, piperine pretreatment enhanced sensitization to paclitaxel killing in HER2-overexpressing breast cancer cells.	piperine	9-17	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
23870999-8	2013	Our findings suggest that piperine may be a potential agent for the prevention and treatment of human breast cancer with HER2 overexpression.	piperine	26-34	erb-b2 receptor tyrosine kinase 2	Homo sapiens	121-125
24689235-1	2013	This study is to explore the amelioration of piperine on chronic acute combining stress rat with depression-like behavior, visceral sensitivity, and its effect on the expression of serotonin (5-HT) and synaptophysin.	piperine	45-53	synaptophysin	Rattus norvegicus	202-215
24689235-8	2013	Piperine improved the behavior of IBS rats, and reversed the levels of 5-HT and 5-HIAA, and 5-HIAA/5-HT proportion in the hippocampus and colon (P&lt;0.05); besides, they significantly reverse the synaptophysin level in the hippocampus and colon (P&lt;0.05).	piperine	0-8	synaptophysin	Rattus norvegicus	197-210
24689235-10	2013	Piperine can ameliorate the changes of the behavior and regulation of serotonin and synaptophysin expression in IBS rat model.	piperine	0-8	synaptophysin	Rattus norvegicus	84-97
24071564-3	2013	Piperine significantly decreased LPS-stimulated gene expression and production of tumor necrosis factor-alpha (TNF&lt;alpha&gt;), inducible NO synthase (iNOS) and COX-2 in RAW264.7 cells.	piperine	0-8	nitric oxide synthase 2, inducible	Mus musculus	153-157
24302912-0	2013	The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK.	piperine	23-31	potassium two pore domain channel subfamily K member 18	Homo sapiens	142-147
24302912-4	2013	We investigated whether the pungent substances piperine, capsaicin, 6-gingerol and polygodial have an effect on human K2P channels.	piperine	47-55	keratin 76	Homo sapiens	118-121
24302912-10	2013	Our data contribute to the relatively sparse knowledge concerning the pharmacology of K2P channels and also raise the question of whether K2P channels could be involved in the pungency perception of piperine.	piperine	199-207	keratin 76	Homo sapiens	138-141
23838114-10	2013	We found that piperine inhibited the production of PGE2 and NO induced by IL-1beta.	piperine	14-22	interleukin 1 beta	Homo sapiens	74-82
23838114-11	2013	Piperine significantly decreased the IL-1beta-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes.	piperine	0-8	interleukin 1 beta	Homo sapiens	37-45
23838114-11	2013	Piperine significantly decreased the IL-1beta-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes.	piperine	0-8	matrix metallopeptidase 3	Homo sapiens	91-96
23838114-11	2013	Piperine significantly decreased the IL-1beta-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes.	piperine	0-8	matrix metallopeptidase 13	Homo sapiens	98-104
23838114-11	2013	Piperine significantly decreased the IL-1beta-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes.	piperine	0-8	nitric oxide synthase 2	Homo sapiens	106-110
23838114-11	2013	Piperine significantly decreased the IL-1beta-stimulated gene expression and production of MMP-3, MMP-13, iNOS and COX-2 in human OA chondrocytes.	piperine	0-8	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
23838114-12	2013	Piperine inhibited the IL-1beta-mediated activation of NF-kappaB by suppressing the degradation of its inhibitory protein IkappaBalpha in the cytoplasm.	piperine	0-8	interleukin 1 beta	Homo sapiens	23-31
23838114-12	2013	Piperine inhibited the IL-1beta-mediated activation of NF-kappaB by suppressing the degradation of its inhibitory protein IkappaBalpha in the cytoplasm.	piperine	0-8	NFKB inhibitor alpha	Homo sapiens	122-134
23838114-14	2013	Piperine can effectively abrogate the IL-1beta-induced over-expression of inflammatory mediators; suggesting that piperine may be a potential agent in the treatment of OA.	piperine	0-8	interleukin 1 beta	Homo sapiens	38-46
23838114-14	2013	Piperine can effectively abrogate the IL-1beta-induced over-expression of inflammatory mediators; suggesting that piperine may be a potential agent in the treatment of OA.	piperine	114-122	interleukin 1 beta	Homo sapiens	38-46
24071564-0	2013	Piperine inhibits LPS induced expression of inflammatory mediators in RAW 264.7 cells.	piperine	0-8	toll-like receptor 4	Mus musculus	18-21
24071564-1	2013	The aim of the present study was to investigate the effects of piperine on the inflammatory responses to lipopolysaccharide (LPS) in RAW264.7 cells and the signal transduction pathways involved.	piperine	63-71	toll-like receptor 4	Mus musculus	125-128
24071564-2	2013	RAW264.7 cells were pretreated with piperine at 10, 50 or 100 mug/ml and subsequently stimulated with LPS (1 mug/ml) for 24 h. We found that piperine inhibited the production of prostaglandin E2 (PGE2) and nitric oxide (NO) induced by LPS.	piperine	141-149	toll-like receptor 4	Mus musculus	102-105
23939040-4	2013	Cell cycle arrest at G0/G1 was induced and cyclin D1 and cyclin A were downregulated upon piperine treatment.	piperine	90-98	cyclin D1	Homo sapiens	43-52
23939040-4	2013	Cell cycle arrest at G0/G1 was induced and cyclin D1 and cyclin A were downregulated upon piperine treatment.	piperine	90-98	cyclin A2	Homo sapiens	57-65
23939040-5	2013	Notably, the level of p21(Cip1) and p27(Kip1) was increased dose-dependently by piperine treatment in both LNCaP and DU145 but not in PC-3 cells, in line with more robust cell cycle arrest in the former two cell lines than the latter one.	piperine	80-88	H3 histone pseudogene 16	Homo sapiens	22-25
23939040-5	2013	Notably, the level of p21(Cip1) and p27(Kip1) was increased dose-dependently by piperine treatment in both LNCaP and DU145 but not in PC-3 cells, in line with more robust cell cycle arrest in the former two cell lines than the latter one.	piperine	80-88	cyclin dependent kinase inhibitor 1A	Homo sapiens	26-30
23939040-5	2013	Notably, the level of p21(Cip1) and p27(Kip1) was increased dose-dependently by piperine treatment in both LNCaP and DU145 but not in PC-3 cells, in line with more robust cell cycle arrest in the former two cell lines than the latter one.	piperine	80-88	interferon alpha inducible protein 27	Homo sapiens	36-39
23939040-5	2013	Notably, the level of p21(Cip1) and p27(Kip1) was increased dose-dependently by piperine treatment in both LNCaP and DU145 but not in PC-3 cells, in line with more robust cell cycle arrest in the former two cell lines than the latter one.	piperine	80-88	cyclin dependent kinase inhibitor 1B	Homo sapiens	40-44
23939040-6	2013	Although piperine induced low levels of apoptosis, it promoted autophagy as evidenced by the increased level of LC3B-II and the formation of LC3B puncta in LNCaP and PC-3 cells.	piperine	9-17	microtubule associated protein 1 light chain 3 beta	Homo sapiens	112-116
23939040-6	2013	Although piperine induced low levels of apoptosis, it promoted autophagy as evidenced by the increased level of LC3B-II and the formation of LC3B puncta in LNCaP and PC-3 cells.	piperine	9-17	microtubule associated protein 1 light chain 3 beta	Homo sapiens	141-145
23939040-7	2013	The piperine-induced autophagic flux was further confirmed by assaying LC3-II accumulation and LC3B puncta formation in the presence of chloroquine, a well-known autophagy inhibitor.	piperine	4-12	microtubule associated protein 1 light chain 3 beta	Homo sapiens	95-99
23707768-0	2013	Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.	piperine	0-8	nuclear receptor subfamily 1 group I member 2	Homo sapiens	25-44
23707768-0	2013	Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.	piperine	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	73-92
23707768-0	2013	Piperine activates human pregnane X receptor to induce the expression of cytochrome P450 3A4 and multidrug resistance protein 1.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	97-127
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	26-34	nuclear receptor subfamily 1 group I member 2	Homo sapiens	130-133
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	26-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	157-176
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	26-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	178-184
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	26-34	ATP binding cassette subfamily B member 1	Homo sapiens	190-220
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	26-34	ATP binding cassette subfamily B member 1	Homo sapiens	222-226
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	36-39	nuclear receptor subfamily 1 group I member 2	Homo sapiens	130-133
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	36-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	157-176
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	36-39	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	178-184
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	36-39	ATP binding cassette subfamily B member 1	Homo sapiens	190-220
23707768-3	2013	Here, we studied, whether piperine (PIP), a major component extracted from the widely-used daily spice black pepper, could induce PXR-mediated expression of cytochrome P450 3A4 (CYP3A4) and multidrug resistance protein 1 (MDR1).	piperine	36-39	ATP binding cassette subfamily B member 1	Homo sapiens	222-226
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	24-27	nuclear receptor subfamily 1 group I member 2	Homo sapiens	44-47
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	24-27	nuclear receptor subfamily 1 group I member 2	Homo sapiens	49-53
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	24-27	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-70
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	24-27	ATP binding cassette subfamily B member 1	Homo sapiens	75-79
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	24-27	nuclear receptor subfamily 1 group I member 2	Homo sapiens	163-167
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	24-27	nuclear receptor coactivator 1	Mus musculus	198-203
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	24-27	nuclear receptor subfamily 1 group I member 2	Homo sapiens	163-167
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	44-47
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	49-53
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	163-167
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor coactivator 1	Mus musculus	198-203
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	163-167
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	44-47
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	49-53
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	163-167
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor coactivator 1	Mus musculus	198-203
23707768-4	2013	Our results showed that PIP activated human PXR (hPXR)-mediated CYP3A4 and MDR1 expression in human hepatocytes, intestine cells, and a mouse model; PIP activated hPXR by recruiting its coactivator SRC-1 in both cellular and cell-free systems; PIP bound to the hPXR ligand binding domain in a competitive ligand binding assay in vitro.	piperine	149-152	nuclear receptor subfamily 1 group I member 2	Homo sapiens	163-167
23707768-5	2013	The dichotomous effects of PIP on induction of CYP3A4 and MDR1 expression observed here and inhibition of their activity reported elsewhere challenges the potential use of PIP as a bioavailability enhancer and suggests that caution should be taken in PIP consumption during drug treatment in patients, particularly those who favor daily pepper spice or rely on certain pepper remedies.	piperine	27-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	47-53
23707768-5	2013	The dichotomous effects of PIP on induction of CYP3A4 and MDR1 expression observed here and inhibition of their activity reported elsewhere challenges the potential use of PIP as a bioavailability enhancer and suggests that caution should be taken in PIP consumption during drug treatment in patients, particularly those who favor daily pepper spice or rely on certain pepper remedies.	piperine	27-30	ATP binding cassette subfamily B member 1	Homo sapiens	58-62
24071564-2	2013	RAW264.7 cells were pretreated with piperine at 10, 50 or 100 mug/ml and subsequently stimulated with LPS (1 mug/ml) for 24 h. We found that piperine inhibited the production of prostaglandin E2 (PGE2) and nitric oxide (NO) induced by LPS.	piperine	141-149	toll-like receptor 4	Mus musculus	235-238
24071564-3	2013	Piperine significantly decreased LPS-stimulated gene expression and production of tumor necrosis factor-alpha (TNF&lt;alpha&gt;), inducible NO synthase (iNOS) and COX-2 in RAW264.7 cells.	piperine	0-8	toll-like receptor 4	Mus musculus	33-36
24071564-3	2013	Piperine significantly decreased LPS-stimulated gene expression and production of tumor necrosis factor-alpha (TNF&lt;alpha&gt;), inducible NO synthase (iNOS) and COX-2 in RAW264.7 cells.	piperine	0-8	tumor necrosis factor	Mus musculus	82-109
24071564-3	2013	Piperine significantly decreased LPS-stimulated gene expression and production of tumor necrosis factor-alpha (TNF&lt;alpha&gt;), inducible NO synthase (iNOS) and COX-2 in RAW264.7 cells.	piperine	0-8	tumor necrosis factor	Mus musculus	111-114
24071564-3	2013	Piperine significantly decreased LPS-stimulated gene expression and production of tumor necrosis factor-alpha (TNF&lt;alpha&gt;), inducible NO synthase (iNOS) and COX-2 in RAW264.7 cells.	piperine	0-8	nitric oxide synthase 2, inducible	Mus musculus	130-151
24071564-3	2013	Piperine significantly decreased LPS-stimulated gene expression and production of tumor necrosis factor-alpha (TNF&lt;alpha&gt;), inducible NO synthase (iNOS) and COX-2 in RAW264.7 cells.	piperine	0-8	cytochrome c oxidase II, mitochondrial	Mus musculus	163-168
24071564-4	2013	Piperine inhibited the LPS-mediated activation of nuclear factor-kappa B (NF-kappaB) by suppressing the degradation of inhibitor-kappaB proteins (IkappaB) and the translocations of p65 subunit of NF-kB from the cytosol to the nucleus.	piperine	0-8	toll-like receptor 4	Mus musculus	23-26
24071564-4	2013	Piperine inhibited the LPS-mediated activation of nuclear factor-kappa B (NF-kappaB) by suppressing the degradation of inhibitor-kappaB proteins (IkappaB) and the translocations of p65 subunit of NF-kB from the cytosol to the nucleus.	piperine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	50-72
24071564-4	2013	Piperine inhibited the LPS-mediated activation of nuclear factor-kappa B (NF-kappaB) by suppressing the degradation of inhibitor-kappaB proteins (IkappaB) and the translocations of p65 subunit of NF-kB from the cytosol to the nucleus.	piperine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	74-83
24046811-2	2013	The MS experiments on these compounds at concentration 5 ng/muL or above yielded dimeric ionic species [2 M + Na](+) which revealed that piperine and its analogues exhibit clustering of ions when the solutions of these compounds at concentrations 5 ng/muL or above were allowed to move through the electrospray interface of the mass spectrometer.	piperine	137-145	tripartite motif containing 37	Homo sapiens	60-63
24046811-2	2013	The MS experiments on these compounds at concentration 5 ng/muL or above yielded dimeric ionic species [2 M + Na](+) which revealed that piperine and its analogues exhibit clustering of ions when the solutions of these compounds at concentrations 5 ng/muL or above were allowed to move through the electrospray interface of the mass spectrometer.	piperine	137-145	tripartite motif containing 37	Homo sapiens	252-255
23911889-6	2013	Piperine also significantly reduced the incidence of MES-induced tonic hindlimb extension (THE) and PTZ-induced Fos immunoreactivity in the dentate gyrus.	piperine	0-8	FBJ osteosarcoma oncogene	Mus musculus	112-115
23911889-7	2013	The anti-seizure effects of piperine were blocked by a TRPV1-selective antagonist capsazepine.	piperine	28-36	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	55-60
23911889-0	2013	Piperine exerts anti-seizure effects via the TRPV1 receptor in mice.	piperine	0-8	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-50
23911889-8	2013	Taken together, these data support the further investigation of piperine as a TRPV1 agonist for anti-seizure therapy.	piperine	64-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
23911889-2	2013	Piperine could activate transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor, and the rapid activation of whole-cell currents is antagonized by the competitive TRPV1 antagonist capsazepine.	piperine	0-8	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	90-95
23921080-7	2013	RESULTS: Piperine was effective in bringing significant changes on all the parameters (articular elastase, MPO, LPO, GSH, Catalase, SOD and NO) studied.	piperine	9-17	lactoperoxidase	Rattus norvegicus	112-115
23911889-2	2013	Piperine could activate transient receptor potential cation channel subfamily V member 1 (TRPV1) receptor, and the rapid activation of whole-cell currents is antagonized by the competitive TRPV1 antagonist capsazepine.	piperine	0-8	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	189-194
23911889-3	2013	Interestingly, recent studies have reported that TRPV1 may be a novel anti-epileptogenic target which led us to hypothesize that the anti-seizure property of piperine involves the TRPV1 receptor.	piperine	158-166	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	49-54
23911889-3	2013	Interestingly, recent studies have reported that TRPV1 may be a novel anti-epileptogenic target which led us to hypothesize that the anti-seizure property of piperine involves the TRPV1 receptor.	piperine	158-166	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	180-185
23921080-7	2013	RESULTS: Piperine was effective in bringing significant changes on all the parameters (articular elastase, MPO, LPO, GSH, Catalase, SOD and NO) studied.	piperine	9-17	myeloperoxidase	Rattus norvegicus	107-110
23921080-7	2013	RESULTS: Piperine was effective in bringing significant changes on all the parameters (articular elastase, MPO, LPO, GSH, Catalase, SOD and NO) studied.	piperine	9-17	catalase	Rattus norvegicus	122-130
23921080-8	2013	Oral administration of piperine resulted in significantly reduced the levels of pro-inflammatory mediators (IL-1beta, TNF-alpha and PGE2) and increased level of IL-10.	piperine	23-31	interleukin 1 beta	Rattus norvegicus	108-116
23921080-8	2013	Oral administration of piperine resulted in significantly reduced the levels of pro-inflammatory mediators (IL-1beta, TNF-alpha and PGE2) and increased level of IL-10.	piperine	23-31	tumor necrosis factor	Rattus norvegicus	118-127
23921080-8	2013	Oral administration of piperine resulted in significantly reduced the levels of pro-inflammatory mediators (IL-1beta, TNF-alpha and PGE2) and increased level of IL-10.	piperine	23-31	interleukin 10	Rattus norvegicus	161-166
23824300-5	2013	Here, we show that piperine inhibited the proliferation of LNCaP, PC-3, 22RV1 and DU-145 prostate cancer cells in a dose dependent manner.	piperine	19-27	proprotein convertase subtilisin/kexin type 1	Homo sapiens	66-77
23648557-5	2013	Piperine was identified as the active compound acting on alpha1A receptors.	piperine	0-8	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	57-64
23648557-6	2013	A competitive binding assay and molecular docking assay were performed to investigate the binding sites and the affinity of piperine for the alpha1A receptor.	piperine	124-132	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	141-148
23824300-6	2013	Furthermore, Annexin-V staining demonstrated that piperine treatment induced apoptosis in hormone dependent prostate cancer cells (LNCaP).	piperine	50-58	annexin A5	Homo sapiens	13-22
23824300-8	2013	Further studies revealed that piperine treatment resulted in the activation of caspase-3 and cleavage of PARP-1 proteins in LNCaP, PC-3 and DU-145 prostate cancer cells.	piperine	30-38	caspase 3	Homo sapiens	79-88
23824300-8	2013	Further studies revealed that piperine treatment resulted in the activation of caspase-3 and cleavage of PARP-1 proteins in LNCaP, PC-3 and DU-145 prostate cancer cells.	piperine	30-38	poly(ADP-ribose) polymerase 1	Homo sapiens	105-111
23824300-9	2013	Piperine treatment also disrupted androgen receptor (AR) expression in LNCaP prostate cancer cells.	piperine	0-8	androgen receptor	Homo sapiens	34-51
23824300-9	2013	Piperine treatment also disrupted androgen receptor (AR) expression in LNCaP prostate cancer cells.	piperine	0-8	androgen receptor	Homo sapiens	53-55
23824300-10	2013	Our evaluations further show that there is a significant reduction of Prostate Specific Antigen (PSA) levels following piperine treatment in LNCaP cells.	piperine	119-127	kallikrein related peptidase 3	Homo sapiens	70-95
23824300-12	2013	Interestingly, treatment of LNCaP, PC-3 and DU-145 prostate cancer cells with piperine resulted in reduced expression of phosphorylated STAT-3 and Nuclear factor-kappaB (NF-kB) transcription factors.	piperine	78-86	signal transducer and activator of transcription 3	Homo sapiens	136-142
22902327-5	2013	Although piperine binds to and activates the cation channel transient receptor potential vanilloid 1 (TRPV1), its effects on endothelial cells did not involve TRPV1 since the antiproliferative effect of piperine was not affected by TRPV1-selective antagonists, nor did HUVECs express detectable TRPV1 mRNA.	piperine	9-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
22819561-4	2013	Furthermore, Piperine treatment diminished cytochrome-c release from mitochondria and reduced caspase-3 and caspase-9 activation induced by 6-OHDA.	piperine	13-21	caspase 3	Rattus norvegicus	94-103
22819561-4	2013	Furthermore, Piperine treatment diminished cytochrome-c release from mitochondria and reduced caspase-3 and caspase-9 activation induced by 6-OHDA.	piperine	13-21	caspase 9	Rattus norvegicus	108-117
22819561-5	2013	Treatment with Piperine markedly inhibited poly(ADP-ribose) polymerase activation, pro-apoptotic Bax levels and elevation of Bcl-2 levels.	piperine	15-23	poly (ADP-ribose) polymerase 1	Rattus norvegicus	43-70
22819561-5	2013	Treatment with Piperine markedly inhibited poly(ADP-ribose) polymerase activation, pro-apoptotic Bax levels and elevation of Bcl-2 levels.	piperine	15-23	BCL2 associated X, apoptosis regulator	Rattus norvegicus	97-100
22819561-5	2013	Treatment with Piperine markedly inhibited poly(ADP-ribose) polymerase activation, pro-apoptotic Bax levels and elevation of Bcl-2 levels.	piperine	15-23	BCL2, apoptosis regulator	Rattus norvegicus	125-130
22819561-8	2013	In addition Piperine depletes inflammatory markers, TNF-alpha and IL-1beta in 6-OHDA-induced Parkinson"s rats.	piperine	12-20	tumor necrosis factor	Rattus norvegicus	52-61
22819561-8	2013	In addition Piperine depletes inflammatory markers, TNF-alpha and IL-1beta in 6-OHDA-induced Parkinson"s rats.	piperine	12-20	interleukin 1 alpha	Rattus norvegicus	66-74
22725836-2	2013	Previous in vitro studies indicate that curcuminoids and piperine (a black pepper derivative that enhances curcuminoid bioavailability) could inhibit human CYP3A, CYP2C9, UGT and SULT dependent drug metabolism.	piperine	57-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	156-161
22725836-2	2013	Previous in vitro studies indicate that curcuminoids and piperine (a black pepper derivative that enhances curcuminoid bioavailability) could inhibit human CYP3A, CYP2C9, UGT and SULT dependent drug metabolism.	piperine	57-65	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	163-169
22725836-2	2013	Previous in vitro studies indicate that curcuminoids and piperine (a black pepper derivative that enhances curcuminoid bioavailability) could inhibit human CYP3A, CYP2C9, UGT and SULT dependent drug metabolism.	piperine	57-65	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	171-174
23063564-5	2013	Piperine also caused HRT-18 cells to die by apoptosis, as determined by Annexin-V-FLUOS staining and characteristic changes in cell morphology.	piperine	0-8	annexin A5	Homo sapiens	72-81
23426652-0	2013	Enhanced oral absorption of 20(S)-protopanaxadiol by self-assembled liquid crystalline nanoparticles containing piperine: in vitro and in vivo studies.	piperine	112-120	visual system homeobox 1	Homo sapiens	28-49
23426652-3	2013	METHODS: In this study, we used cubic nanoparticles containing piperine to improve the oral bioavailability of PPD and to enhance its absorption and inhibit its metabolism.	piperine	63-71	visual system homeobox 1	Homo sapiens	111-114
23426652-7	2013	PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3) increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively.	piperine	42-50	visual system homeobox 1	Homo sapiens	0-3
23426652-7	2013	PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3) increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively.	piperine	42-50	visual system homeobox 1	Homo sapiens	17-20
23426652-7	2013	PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3) increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively.	piperine	42-50	visual system homeobox 1	Homo sapiens	17-20
23426652-7	2013	PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3) increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively.	piperine	68-76	visual system homeobox 1	Homo sapiens	17-20
23426652-7	2013	PPD-cubosome and PPD-cubosome loaded with piperine (molar ratio PPD/piperine, 1:3) increased the apical to basolateral permeability values of PPD across the Caco-2 cell monolayer from 53% to 64%, respectively.	piperine	68-76	visual system homeobox 1	Homo sapiens	17-20
23426652-8	2013	In addition, the results of a pharmacokinetic study in rats showed that the relative bioavailabilities of PPD-cubosome [area under concentration-time curve (AUC)(0- )] and PPD-cubosome containing piperine (AUC(0- )) compared to that of raw PPD (AUC(0- )) were 166% and 248%, respectively.	piperine	196-204	visual system homeobox 1	Homo sapiens	172-175
23426652-8	2013	In addition, the results of a pharmacokinetic study in rats showed that the relative bioavailabilities of PPD-cubosome [area under concentration-time curve (AUC)(0- )] and PPD-cubosome containing piperine (AUC(0- )) compared to that of raw PPD (AUC(0- )) were 166% and 248%, respectively.	piperine	196-204	visual system homeobox 1	Homo sapiens	172-175
23426652-9	2013	CONCLUSION: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD.	piperine	70-78	visual system homeobox 1	Homo sapiens	45-48
23426652-9	2013	CONCLUSION: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD.	piperine	70-78	visual system homeobox 1	Homo sapiens	147-150
22864626-0	2013	A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors.	piperine	87-95	PGP	Canis lupus familiaris	56-60
22864626-0	2013	A plausible explanation for enhanced bioavailability of P-gp substrates in presence of piperine: simulation for next generation of P-gp inhibitors.	piperine	87-95	PGP	Canis lupus familiaris	131-135
22864626-2	2013	Piperine is known to enhance the bioavailability of curcumin, as a substrate of P-gp by at least 2000%.	piperine	0-8	PGP	Canis lupus familiaris	80-84
22864626-7	2013	Computational simulation for piperine and some first and second generation P-gp inhibitors has shown that these dock at the NBD site of P-gp.	piperine	29-37	PGP	Canis lupus familiaris	75-79
22864626-7	2013	Computational simulation for piperine and some first and second generation P-gp inhibitors has shown that these dock at the NBD site of P-gp.	piperine	29-37	PGP	Canis lupus familiaris	136-140
22864626-9	2013	Binding conformation of P-gp co-crystallized complexes with ADP, AMP-PNP (Adenylyl-imidodiphosphate), and ATP were compared with piperine.	piperine	129-137	PGP	Canis lupus familiaris	24-28
22864626-10	2013	The receptor based E-pharmacophore of docked piperine has been simulated to find common features amongst P-gp inhibitors.	piperine	45-53	PGP	Canis lupus familiaris	105-109
22864626-11	2013	Finally it has been concluded that piperine could be utilized as base molecule for design and development of safe non-toxic inhibitor of P-gp in order to enhance the bioavailability of most of its substrates.	piperine	35-43	PGP	Canis lupus familiaris	137-141
23537660-5	2013	A CAP inhibition was seen by hydroxy-alpha-sanshool (by 60% at 0.05 mM), which activates both TRPA1 and TRPV1 channels, a non-vanilloid TRPV1 agonist piperine (by 20% at 0.07 mM) and tetrahydrolavandulol (where the six-membered ring of menthol is opened; IC50=0.38 mM).	piperine	150-158	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-109
23537660-5	2013	A CAP inhibition was seen by hydroxy-alpha-sanshool (by 60% at 0.05 mM), which activates both TRPA1 and TRPV1 channels, a non-vanilloid TRPV1 agonist piperine (by 20% at 0.07 mM) and tetrahydrolavandulol (where the six-membered ring of menthol is opened; IC50=0.38 mM).	piperine	150-158	transient receptor potential cation channel subfamily V member 1	Homo sapiens	136-141
23313550-16	2013	Taken together, piperine anticonvulsant effects are the result of its anti-inflammatory and antioxidant actions, as well as TNF-alpha reduction.	piperine	16-24	tumor necrosis factor	Mus musculus	124-133
23426652-9	2013	CONCLUSION: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD.	piperine	70-78	visual system homeobox 1	Homo sapiens	147-150
23426652-9	2013	CONCLUSION: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD.	piperine	185-193	visual system homeobox 1	Homo sapiens	45-48
23426652-9	2013	CONCLUSION: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD.	piperine	185-193	visual system homeobox 1	Homo sapiens	147-150
23426652-9	2013	CONCLUSION: The increased bioavailability of PPD-cubosome loaded with piperine is due to an increase in absorption and inhibition of metabolism of PPD by cubic nanoparticles containing piperine rather than because of improved release of PPD.	piperine	185-193	visual system homeobox 1	Homo sapiens	147-150
22902327-6	2013	Importantly, piperine inhibited phosphorylation of Ser 473 and Thr 308 residues of Akt (protein kinase B), which is a key regulator of endothelial cell function and angiogenesis.	piperine	13-21	AKT serine/threonine kinase 1	Homo sapiens	83-86
22902327-7	2013	Consistent with Akt inhibition as the basis of piperine"s action on HUVECs, inhibition of the phosphoinositide-3 kinase/Akt signaling pathway with LY-294002 also inhibited HUVEC proliferation and collagen-induced angiogenesis.	piperine	47-55	AKT serine/threonine kinase 1	Homo sapiens	16-19
23000915-0	2012	Piperine, an LXRalpha antagonist, protects against hepatic steatosis and improves insulin signaling in mice fed a high-fat diet.	piperine	0-8	nuclear receptor subfamily 1, group H, member 3	Mus musculus	13-21
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	piperine	43-51	prohibitin 2	Mus musculus	77-80
23909733-5	2013	Pretreatment of curcumin and curcumin plus piperine before administration of BaP significantly decreased the activities of EROD, PROD, and the level of BaPDE-DNA adducts with consequent increase in QR activities.	piperine	43-51	crystallin, zeta	Mus musculus	198-200
23000915-3	2012	In the present study, piperine significantly reduced ligand-induced LXRalpha activity in a dose-dependent manner and gradually disrupted the interaction between ligand-bound LXRalpha and GST-CBP.	piperine	22-30	nuclear receptor subfamily 1, group H, member 3	Mus musculus	68-76
23156991-5	2012	The results revealed that a combination of glimepiride with piperine led to the enhancement of the bioavailability of glimepiride by inhibiting the CYP2C9 enzyme, which suggested that piperine might be beneficial as an adjuvant to glimepiride in a proper dose, in diabetic patients.	piperine	60-68	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	148-154
23000915-3	2012	In the present study, piperine significantly reduced ligand-induced LXRalpha activity in a dose-dependent manner and gradually disrupted the interaction between ligand-bound LXRalpha and GST-CBP.	piperine	22-30	nuclear receptor subfamily 1, group H, member 3	Mus musculus	174-182
23000915-3	2012	In the present study, piperine significantly reduced ligand-induced LXRalpha activity in a dose-dependent manner and gradually disrupted the interaction between ligand-bound LXRalpha and GST-CBP.	piperine	22-30	CREB binding protein	Mus musculus	191-194
23000915-5	2012	In agreement with our in vitro study, in mice fed an HFD, dietary piperine markedly decreased LXRalpha mRNA expression and its lipogenic target genes (i.e., SREBP1c, ChREBPalpha, FAS, and CD36).	piperine	66-74	nuclear receptor subfamily 1, group H, member 3	Mus musculus	94-102
23000915-5	2012	In agreement with our in vitro study, in mice fed an HFD, dietary piperine markedly decreased LXRalpha mRNA expression and its lipogenic target genes (i.e., SREBP1c, ChREBPalpha, FAS, and CD36).	piperine	66-74	sterol regulatory element binding transcription factor 1	Mus musculus	157-164
23000915-7	2012	In addition, piperine downregulated the expression of genes involved in ER stress, including GRP78, activating transcription factor 6, and eukaryotic translation initiation factor 2alpha, and upregulated GLUT2 translocation from the cytosol to the plasma membrane in the livers of PSD mice.	piperine	13-21	heat shock protein 5	Mus musculus	93-98
23000915-7	2012	In addition, piperine downregulated the expression of genes involved in ER stress, including GRP78, activating transcription factor 6, and eukaryotic translation initiation factor 2alpha, and upregulated GLUT2 translocation from the cytosol to the plasma membrane in the livers of PSD mice.	piperine	13-21	activating transcription factor 6	Mus musculus	100-133
23000915-7	2012	In addition, piperine downregulated the expression of genes involved in ER stress, including GRP78, activating transcription factor 6, and eukaryotic translation initiation factor 2alpha, and upregulated GLUT2 translocation from the cytosol to the plasma membrane in the livers of PSD mice.	piperine	13-21	eukaryotic translation initiation factor 2A	Mus musculus	139-186
23000915-7	2012	In addition, piperine downregulated the expression of genes involved in ER stress, including GRP78, activating transcription factor 6, and eukaryotic translation initiation factor 2alpha, and upregulated GLUT2 translocation from the cytosol to the plasma membrane in the livers of PSD mice.	piperine	13-21	solute carrier family 2 (facilitated glucose transporter), member 2	Mus musculus	204-209
23000915-8	2012	Piperine antagonized LXRalpha transcriptional activity by abolishing the interaction of ligand-bound LXRalpha with the co-activator CBP.	piperine	0-8	nuclear receptor subfamily 1, group H, member 3	Mus musculus	21-29
23000915-8	2012	Piperine antagonized LXRalpha transcriptional activity by abolishing the interaction of ligand-bound LXRalpha with the co-activator CBP.	piperine	0-8	nuclear receptor subfamily 1, group H, member 3	Mus musculus	101-109
23000915-8	2012	Piperine antagonized LXRalpha transcriptional activity by abolishing the interaction of ligand-bound LXRalpha with the co-activator CBP.	piperine	0-8	CREB binding protein	Mus musculus	132-135
23000915-9	2012	The effects of piperine on hepatic lipid accumulation were likely regulated via alterations in LXRalpha-mediated lipogenesis in mice fed an HFD.	piperine	15-23	nuclear receptor subfamily 1, group H, member 3	Mus musculus	95-103
22927137-0	2012	Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats.	piperine	19-27	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	55-69
22927137-0	2012	Repeated dosing of piperine induced gene expression of P-glycoprotein via stimulated pregnane-X-receptor activity and altered pharmacokinetics of diltiazem in rats.	piperine	19-27	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	85-104
22927137-1	2012	This study investigated the effect of piperine on the gene expression of P-glycoprotein (P-gp) as well as pregnane-X-receptor (PXR) activity and also its implication on the bioavailability of diltiazem, a P-gp substrate.	piperine	38-46	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	73-87
22927137-1	2012	This study investigated the effect of piperine on the gene expression of P-glycoprotein (P-gp) as well as pregnane-X-receptor (PXR) activity and also its implication on the bioavailability of diltiazem, a P-gp substrate.	piperine	38-46	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	89-93
22927137-7	2012	Immunoblot analysis indicated that the protein expression level of intestinal P-gp was significantly enhanced after the 2 week pretreatment with piperine in rats.	piperine	145-153	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	78-82
22927137-8	2012	In addition, piperine increased the PXR reporter activity in human hepatoma cells.	piperine	13-21	nuclear receptor subfamily 1 group I member 2	Homo sapiens	36-39
22927137-9	2012	Taken together, the 2 week pretreatment with piperine significantly induced intestinal P-gp expression in conjunction with stimulated PXR activity and decreased the oral exposure of diltiazem and desacetyldiltiazem in rats.	piperine	45-53	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	87-91
22927137-9	2012	Taken together, the 2 week pretreatment with piperine significantly induced intestinal P-gp expression in conjunction with stimulated PXR activity and decreased the oral exposure of diltiazem and desacetyldiltiazem in rats.	piperine	45-53	nuclear receptor subfamily 1, group I, member 2	Rattus norvegicus	134-137
23156991-5	2012	The results revealed that a combination of glimepiride with piperine led to the enhancement of the bioavailability of glimepiride by inhibiting the CYP2C9 enzyme, which suggested that piperine might be beneficial as an adjuvant to glimepiride in a proper dose, in diabetic patients.	piperine	184-192	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	148-154
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	piperine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	30-46
22669728-0	2012	Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-kappaB in middle cerebral artery occlusion rat model.	piperine	0-8	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	97-102
22669728-0	2012	Piperine suppresses cerebral ischemia-reperfusion-induced inflammation through the repression of COX-2, NOS-2, and NF-kappaB in middle cerebral artery occlusion rat model.	piperine	0-8	nitric oxide synthase 2	Rattus norvegicus	104-109
22669728-7	2012	Piperine successfully reduced the level of proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha, in ischemic group (p &lt; 0.01).	piperine	0-8	interleukin 1 beta	Rattus norvegicus	69-77
22669728-7	2012	Piperine successfully reduced the level of proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha, in ischemic group (p &lt; 0.01).	piperine	0-8	interleukin 6	Rattus norvegicus	79-83
22669728-7	2012	Piperine successfully reduced the level of proinflammatory cytokines IL-1beta, IL-6 and TNF-alpha, in ischemic group (p &lt; 0.01).	piperine	0-8	tumor necrosis factor	Rattus norvegicus	88-97
22669728-9	2012	Moreover, piperine also succeeded in lowering the expression of COX-2, NOS-2, and NF-kappaB (p &lt; 0.01).	piperine	10-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	64-69
22669728-9	2012	Moreover, piperine also succeeded in lowering the expression of COX-2, NOS-2, and NF-kappaB (p &lt; 0.01).	piperine	10-18	nitric oxide synthase 2	Rattus norvegicus	71-76
22542552-6	2012	In addition, piperine inhibited PMA-induced NF-kappaB, C/EBP and c-Jun nuclear translocation.	piperine	13-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
22542552-6	2012	In addition, piperine inhibited PMA-induced NF-kappaB, C/EBP and c-Jun nuclear translocation.	piperine	13-21	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	55-60
22542552-6	2012	In addition, piperine inhibited PMA-induced NF-kappaB, C/EBP and c-Jun nuclear translocation.	piperine	13-21	jun proto-oncogene	Mus musculus	65-70
22542552-7	2012	Furthermore, piperine significantly inhibited PMA-induced activation of the Akt and ERK.	piperine	13-21	thymoma viral proto-oncogene 1	Mus musculus	76-79
22542552-7	2012	Furthermore, piperine significantly inhibited PMA-induced activation of the Akt and ERK.	piperine	13-21	mitogen-activated protein kinase 1	Mus musculus	84-87
22542552-8	2012	These findings demonstrate that piperine effectively attenuates COX-2 production, and provide further insight into the signal transduction pathways involved in the anti-inflammatory effects of piperine.	piperine	32-40	prostaglandin-endoperoxide synthase 2	Mus musculus	64-69
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	piperine	0-8	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	piperine	0-8	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	92-97
22542552-0	2012	Piperine inhibits PMA-induced cyclooxygenase-2 expression through downregulating NF-kappaB, C/EBP and AP-1 signaling pathways in murine macrophages.	piperine	0-8	jun proto-oncogene	Mus musculus	102-106
22542552-3	2012	In the present study, we investigated the inhibitory effects of piperine on phorbol 12-myristate 13-acetate (PMA)-induced cyclooxygenase-2 (COX-2) gene expression and analyzed the molecular mechanism of its activity in murine RAW 264.7 macrophages.	piperine	64-72	prostaglandin-endoperoxide synthase 2	Mus musculus	122-138
22542552-3	2012	In the present study, we investigated the inhibitory effects of piperine on phorbol 12-myristate 13-acetate (PMA)-induced cyclooxygenase-2 (COX-2) gene expression and analyzed the molecular mechanism of its activity in murine RAW 264.7 macrophages.	piperine	64-72	prostaglandin-endoperoxide synthase 2	Mus musculus	140-145
22542552-4	2012	Piperine dose-dependently decreased PMA-induced COX-2 expression and PGE(2) production, as well as COX-2 promoter-driven luciferase activity.	piperine	0-8	prostaglandin-endoperoxide synthase 2	Mus musculus	48-53
22822540-10	2012	Piperin inhibited Pgp and MRP transporters and decreased the amount of glucuronide transported back into the intestine.	piperine	0-7	phosphoglycolate phosphatase	Homo sapiens	18-21
22822540-10	2012	Piperin inhibited Pgp and MRP transporters and decreased the amount of glucuronide transported back into the intestine.	piperine	0-7	ATP binding cassette subfamily C member 1	Homo sapiens	26-29
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	prohibitin 2	Mus musculus	95-98
22205277-7	2012	In addition, piperine (1 muM) co-treatment was found to reverse the decreased brain-derived neurotrophic factor (BDNF) mRNA level caused by corticosterone in PC12 cells.	piperine	13-21	brain-derived neurotrophic factor	Rattus norvegicus	78-111
22205277-7	2012	In addition, piperine (1 muM) co-treatment was found to reverse the decreased brain-derived neurotrophic factor (BDNF) mRNA level caused by corticosterone in PC12 cells.	piperine	13-21	brain-derived neurotrophic factor	Rattus norvegicus	113-117
22205277-8	2012	The results suggest that piperine exerts a neuroprotective effect on corticosterone-induced neurotoxicity in PC12 cells, at least in part, via the inhibition of oxidative stress and the upregulation of BDNF mRNA expression.	piperine	25-33	brain-derived neurotrophic factor	Rattus norvegicus	202-206
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	glutathione reductase	Mus musculus	231-233
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	catalase	Mus musculus	240-243
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	hematopoietic prostaglandin D synthase	Mus musculus	249-274
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	hematopoietic prostaglandin D synthase	Mus musculus	276-279
22027502-4	2012	Pretreatments with curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of LPO, PCC, and incidence of MNPCEs but elevated the level of GSH and enzyme activities of GPx, GR, SOD, CAT, and glutathione-S-transferase (GST) when compared to the BaP-treated group.	piperine	46-54	prohibitin 2	Mus musculus	302-305
22027502-5	2012	The effect of curcumin plus piperine is more pronounced as compared to curcumin in attenuating BaP-induced oxidative insult and clastogenicity.	piperine	28-36	prohibitin 2	Mus musculus	95-98
21612376-0	2012	Carbonic anhydrase I and II inhibition with natural products: caffeine and piperine.	piperine	75-83	carbonic anhydrase 1	Homo sapiens	0-27
22388073-8	2012	Treatment of 4T1 cells with piperine (70-280 mumol/L) dose-dependently induced apoptosis of 4T1 cells, accompanying activation of caspase 3.	piperine	28-36	caspase 3	Mus musculus	130-139
22388073-9	2012	The cells treated with piperine (140 and 280 mumol/L) significantly increased the percentage of cells in G(2)/M phase with a reduction in the expression of cyclin B1.	piperine	23-31	cyclin B1	Mus musculus	156-165
22388073-10	2012	Piperine (140 and 280 mumol/L) significantly decreased the expression of MMP-9 and MMP-13, and inhibited 4T1 cell migration in vitro.	piperine	0-8	matrix metallopeptidase 9	Mus musculus	73-78
22388073-10	2012	Piperine (140 and 280 mumol/L) significantly decreased the expression of MMP-9 and MMP-13, and inhibited 4T1 cell migration in vitro.	piperine	0-8	matrix metallopeptidase 13	Mus musculus	83-89
22535397-8	2012	Piperine inhibited IL-2 and IFN-gamma production in the PBMCs.	piperine	0-8	interleukin 2	Homo sapiens	19-23
22535397-8	2012	Piperine inhibited IL-2 and IFN-gamma production in the PBMCs.	piperine	0-8	interferon gamma	Homo sapiens	28-37
22535397-9	2012	RT-PCR data indicated that  IL-2 and IFN-gamma mRNA expression in PBMCs is suppressed by  piperine.	piperine	90-98	interleukin 2	Homo sapiens	28-32
22535397-9	2012	RT-PCR data indicated that  IL-2 and IFN-gamma mRNA expression in PBMCs is suppressed by  piperine.	piperine	90-98	interferon gamma	Homo sapiens	37-46
21796656-0	2012	Co-administration of piperine and docetaxel results in improved anti-tumor efficacy via inhibition of CYP3A4 activity.	piperine	21-29	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	102-108
21796656-3	2012	Piperine, a major plant alkaloid/amide, has been shown to inhibit the CYP3A4 enzymatic activity in a cell-free system.	piperine	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	70-76
22463744-0	2012	Piperine, a component of black pepper, inhibits adipogenesis by antagonizing PPARgamma activity in 3T3-L1 cells.	piperine	0-8	peroxisome proliferator activated receptor gamma	Mus musculus	77-86
22463744-6	2012	Finally, GST-pull down assays demonstrated that piperine disrupts the rosiglitazone-dependent interaction between PPARgamma and coactivator CBP.	piperine	48-56	peroxisome proliferator activated receptor gamma	Mus musculus	114-123
22463744-6	2012	Finally, GST-pull down assays demonstrated that piperine disrupts the rosiglitazone-dependent interaction between PPARgamma and coactivator CBP.	piperine	48-56	CREB binding protein	Mus musculus	140-143
22463744-8	2012	Overall, these results suggest that piperine, a major component of black pepper, attenuates fat cell differentiation by down-regulating PPARgamma activity as well as suppressing PPARgamma expression, thus leading to potential treatment for obesity-related diseases.	piperine	36-44	peroxisome proliferator activated receptor gamma	Homo sapiens	136-145
22463744-8	2012	Overall, these results suggest that piperine, a major component of black pepper, attenuates fat cell differentiation by down-regulating PPARgamma activity as well as suppressing PPARgamma expression, thus leading to potential treatment for obesity-related diseases.	piperine	36-44	peroxisome proliferator activated receptor gamma	Homo sapiens	178-187
21612376-4	2012	The IC(50) values of caffeine and piperine against hCA II were of 2 mM.	piperine	34-42	carbonic anhydrase 2	Homo sapiens	51-57
22195361-15	2011	The antidepressant activity of piperine in post-SE rats may be attributed to its MAO inhibitor activity and neuroprotective activity.	piperine	31-39	monoamine oxidase A	Rattus norvegicus	81-84
25205944-0	2011	Molecular interaction of Survivin and Piperine by computational docking analyses for neuroblastoma targeting.	piperine	38-46	baculoviral IAP repeat-containing 5	Mus musculus	25-33
21827816-1	2011	The present study was planned to investigate the antigenotoxic effects of curcumin and piperine separately and in combination against benzo(a)pyrene (BaP) induced DNA damage in lungs and livers of mice.	piperine	87-95	prohibitin 2	Mus musculus	150-153
21827816-4	2011	Pretreatments of curcumin and curcumin plus piperine before administration of single dose of BaP significantly decreased the levels of 8-oxo-dG content and % DNA in the comet tail in both the tissues.	piperine	44-52	prohibitin 2	Mus musculus	93-96
21827816-5	2011	Moreover, the genoprotective potential of curcumin plus piperine was significantly higher as compared to curcumin alone against BaP induced DNA damage.	piperine	56-64	prohibitin 2	Mus musculus	128-131
21964383-0	2011	Role of 5-HT(1A) and 5-HT(1B) receptors in the antidepressant-like effect of piperine in the forced swim test.	piperine	77-85	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	8-15
21964383-4	2011	On the other hand, a sub-effective dose of piperine (1mg/kg, intraperitoneally) produced a synergistic antidepressant-like effect with (+)-8-hydroxy-2-(di-n-propylamino)tetralin (a 5-HT(1A) receptor agonist, 1mg/kg, intraperitoneally) or anpirtoline (a 5-HT(1B) receptor agonist, 0.25mg/kg, intraperitoneally).	piperine	43-51	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	181-198
21964383-4	2011	On the other hand, a sub-effective dose of piperine (1mg/kg, intraperitoneally) produced a synergistic antidepressant-like effect with (+)-8-hydroxy-2-(di-n-propylamino)tetralin (a 5-HT(1A) receptor agonist, 1mg/kg, intraperitoneally) or anpirtoline (a 5-HT(1B) receptor agonist, 0.25mg/kg, intraperitoneally).	piperine	43-51	5-hydroxytryptamine (serotonin) receptor 1B	Mus musculus	253-270
21964383-5	2011	Taken together, these results suggest that the antidepressant-like effect of piperine in the mouse forced swim test may be mediated, at least in part, by the activation of 5-HT(1A) and 5-HT(1B) receptors.	piperine	77-85	5-hydroxytryptamine (serotonin) receptor 1A	Mus musculus	172-179
25205944-5	2011	In this study, a naturally occurring ligand - Piperine was assessed for its interaction with Survivin protein.	piperine	46-54	baculoviral IAP repeat-containing 5	Mus musculus	93-101
25205944-6	2011	PURPOSE: The study was undertaken in order to identify the experimental feasibility of Survivin inhibitor ligand Piperine as targeting treatment of NB.	piperine	113-121	baculoviral IAP repeat-containing 5	Mus musculus	87-95
25205944-12	2011	CONCLUSION: The molecular docking study for mice Survivin and Piperine shows good inhibitory interaction effect and can, therefore, be considered as a molecule against Survivin enhanced tumor condition including NB.	piperine	62-70	baculoviral IAP repeat-containing 5	Mus musculus	49-57
25205944-12	2011	CONCLUSION: The molecular docking study for mice Survivin and Piperine shows good inhibitory interaction effect and can, therefore, be considered as a molecule against Survivin enhanced tumor condition including NB.	piperine	62-70	baculoviral IAP repeat-containing 5	Mus musculus	168-176
21354279-7	2011	Furthermore, piperine strongly repressed the PMA-induced phosphorylation of ERK, which are dependent on the PKCalpha pathway.	piperine	13-21	protein kinase C alpha	Homo sapiens	108-116
21354279-0	2011	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression.	piperine	78-86	protein kinase C alpha	Homo sapiens	109-117
21703243-0	2011	TRPV1 agonist piperine but not olvanil enhances glutamatergic spontaneous excitatory transmission in rat spinal substantia gelatinosa neurons.	piperine	14-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
21703243-6	2011	The facilitatory effect of piperine was blocked by TRPV1 antagonist capsazepine.	piperine	27-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
21703243-7	2011	It is concluded that piperine but not olvanil activates TRPV1 channels in the central terminals of primary-afferent neurons, resulting in an increase in the spontaneous release of l-glutamate onto SG neurons.	piperine	21-29	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
21354279-8	2011	In conclusion, we demonstrated that the anti-invasive effects of piperine may occur through inhibition of PKCalpha and ERK phosphorylation and reduction of NF-kappaB and AP-1 activation, leading to down-regulation of MMP-9 expression.	piperine	65-73	protein kinase C alpha	Homo sapiens	106-114
21354279-0	2011	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression.	piperine	78-86	mitogen-activated protein kinase 3	Homo sapiens	118-124
21354279-0	2011	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by piperine via the inhibition of PKCalpha/ERK1/2-dependent matrix metalloproteinase-9 expression.	piperine	78-86	matrix metallopeptidase 9	Homo sapiens	135-161
21354279-4	2011	We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	piperine	14-22	matrix metallopeptidase 9	Homo sapiens	47-73
21354279-4	2011	We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	piperine	14-22	matrix metallopeptidase 9	Homo sapiens	75-80
21354279-4	2011	We found that piperine suppresses PMA-enhanced matrix metalloproteinase-9 (MMP-9) expression at the protein, mRNA, and transcriptional levels through the suppression of NF-kappaB and AP-1 activation without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1.	piperine	14-22	TIMP metallopeptidase inhibitor 1	Homo sapiens	229-275
21354279-5	2011	Piperine also inhibits PMA-enhanced membrane-type 1 MMP expression without changing the level of tissue inhibitor of metalloproteinase (TIMP)-1 and TIMP-2.	piperine	0-8	matrix metallopeptidase 9	Homo sapiens	52-55
21354279-8	2011	In conclusion, we demonstrated that the anti-invasive effects of piperine may occur through inhibition of PKCalpha and ERK phosphorylation and reduction of NF-kappaB and AP-1 activation, leading to down-regulation of MMP-9 expression.	piperine	65-73	mitogen-activated protein kinase 1	Homo sapiens	119-122
21354279-8	2011	In conclusion, we demonstrated that the anti-invasive effects of piperine may occur through inhibition of PKCalpha and ERK phosphorylation and reduction of NF-kappaB and AP-1 activation, leading to down-regulation of MMP-9 expression.	piperine	65-73	matrix metallopeptidase 9	Homo sapiens	217-222
21333639-0	2011	Involvement of P-glycoprotein and CYP 3A4 in the enhancement of etoposide bioavailability by a piperine analogue.	piperine	95-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	34-41
21354279-6	2011	Piperine inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion.	piperine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	45-50
21354279-6	2011	Piperine inhibited PMA-induced NF-kappaB and c-Jun nuclear translocation, which are upstream of PMA-induced MMP-9 expression and invasion.	piperine	0-8	matrix metallopeptidase 9	Homo sapiens	108-113
21354279-7	2011	Furthermore, piperine strongly repressed the PMA-induced phosphorylation of ERK, which are dependent on the PKCalpha pathway.	piperine	13-21	mitogen-activated protein kinase 1	Homo sapiens	76-79
20381363-0	2010	In vitro TRPV1 activity of piperine derived amides.	piperine	27-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-14
20621590-5	2010	Administration of piperine inhibited LPS-induced endotoxin shock, leukocyte accumulation and the production of tumor necrosis factor-alpha (TNF-alpha), but not of interleukin (IL)-1beta and IL-6.	piperine	18-26	tumor necrosis factor	Mus musculus	111-138
20621590-5	2010	Administration of piperine inhibited LPS-induced endotoxin shock, leukocyte accumulation and the production of tumor necrosis factor-alpha (TNF-alpha), but not of interleukin (IL)-1beta and IL-6.	piperine	18-26	tumor necrosis factor	Mus musculus	140-149
20621590-6	2010	In peritoneal macrophages, piperine inhibited LPS/poly (I:C)/CpG-ODN-induced TNF-alpha production.	piperine	27-35	tumor necrosis factor	Mus musculus	77-86
20621590-7	2010	Piperine also inhibited LPS-induced endotoxin shock in TNF-alpha knockout (KO) mice.	piperine	0-8	tumor necrosis factor	Mus musculus	55-64
20621590-10	2010	Piperine inhibited the levels of interferon regulatory factor (IRF)-1 and IRF-7 mRNA, and the phosphorylation and nuclear translocation of IRF-3.	piperine	0-8	interferon regulatory factor 1	Mus musculus	33-69
20621590-10	2010	Piperine inhibited the levels of interferon regulatory factor (IRF)-1 and IRF-7 mRNA, and the phosphorylation and nuclear translocation of IRF-3.	piperine	0-8	interferon regulatory factor 7	Mus musculus	74-79
20621590-10	2010	Piperine inhibited the levels of interferon regulatory factor (IRF)-1 and IRF-7 mRNA, and the phosphorylation and nuclear translocation of IRF-3.	piperine	0-8	interferon regulatory factor 3	Mus musculus	139-144
20621590-11	2010	Piperine also reduced activation of signal transducer and activator of transcription (STAT)-1.	piperine	0-8	signal transducer and activator of transcription 1	Mus musculus	36-93
20621590-12	2010	In addition, activation of STAT-1 was inhibited in IFN-alpha/beta-treated cells by piperine.	piperine	83-91	signal transducer and activator of transcription 1	Mus musculus	27-33
20621590-12	2010	In addition, activation of STAT-1 was inhibited in IFN-alpha/beta-treated cells by piperine.	piperine	83-91	interferon alpha	Mus musculus	51-60
20118549-1	2010	The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells).	piperine	151-159	ATP binding cassette subfamily B member 1	Homo sapiens	96-110
20176514-0	2010	Simultaneous determination of etoposide and a piperine analogue (PA-1) by UPLC-qTOF-MS: evidence that PA-1 enhances the oral bioavailability of etoposide in mice.	piperine	46-54	PAXIP1 associated glutamate rich protein 1A	Mus musculus	65-69
20176514-0	2010	Simultaneous determination of etoposide and a piperine analogue (PA-1) by UPLC-qTOF-MS: evidence that PA-1 enhances the oral bioavailability of etoposide in mice.	piperine	46-54	PAXIP1 associated glutamate rich protein 1A	Mus musculus	102-106
20176514-1	2010	In the present investigation, a UPLC-qTOF-MS/MS method has been developed for the simultaneous determination of etoposide and a piperine analogue, namely, 4-ethyl 5-(3,4-methylenedioxyphenyl)-2E,4E-pentadienoic acid piperidide (PA-1).	piperine	128-136	PAXIP1 associated glutamate rich protein 1A	Mus musculus	228-232
20118549-3	2010	These results suggest that the P-glycoprotein-mediated efflux is inhibited by piperine, capsaicin and sesamin and stimulated by daidzein and genistein.	piperine	78-86	ATP binding cassette subfamily B member 1	Homo sapiens	31-45
20118549-1	2010	The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells).	piperine	151-159	ATP binding cassette subfamily B member 1	Homo sapiens	112-117
20118549-4	2010	The concurrent addition of piperine and capsaicin seemed to inhibit synergistically the P-glycoprotein-mediated efflux.	piperine	27-35	ATP binding cassette subfamily B member 1	Homo sapiens	88-102
20460725-3	2010	Among these, piperine, isopiperine, isochavicine, piperanine, pipernonaline, dehydropipernonaline, retrofractamide C, piperolein A, and piperolein B relatively strongly activated TRPV1.	piperine	13-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	179-184
20118549-7	2010	Piperine, genistein and curcumin have been suggested to stimulate P-glycoprotein-mediated efflux without increasing P-glycoprotein expression.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	66-80
20118549-8	2010	In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.	piperine	172-180	ATP binding cassette subfamily C member 1	Homo sapiens	58-100
20118549-8	2010	In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.	piperine	172-180	ATP binding cassette subfamily C member 1	Homo sapiens	102-106
20118549-8	2010	In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.	piperine	172-180	ATP binding cassette subfamily C member 3	Homo sapiens	111-115
20118549-10	2010	Also, capsaicin, daidzein, piperine and sesamin increased significantly the mRNA expression of MRP1 or MRP3.	piperine	27-35	ATP binding cassette subfamily C member 1	Homo sapiens	95-99
20118549-10	2010	Also, capsaicin, daidzein, piperine and sesamin increased significantly the mRNA expression of MRP1 or MRP3.	piperine	27-35	ATP binding cassette subfamily C member 3	Homo sapiens	103-107
21033621-8	2010	Piperine decreased the blood pressure rise from the third week of treatment, synthesis of elastin and the percentual and absolute content of PTAH positive myofibrils, however, it did not affect other parameters.	piperine	0-8	elastin	Rattus norvegicus	90-97
20460725-3	2010	Among these, piperine, isopiperine, isochavicine, piperanine, pipernonaline, dehydropipernonaline, retrofractamide C, piperolein A, and piperolein B relatively strongly activated TRPV1.	piperine	23-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	179-184
20460725-3	2010	Among these, piperine, isopiperine, isochavicine, piperanine, pipernonaline, dehydropipernonaline, retrofractamide C, piperolein A, and piperolein B relatively strongly activated TRPV1.	piperine	36-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	179-184
20460725-7	2010	We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.	piperine	115-123	transient receptor potential cation channel subfamily V member 1	Homo sapiens	210-215
20460725-7	2010	We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.	piperine	115-123	transient receptor potential cation channel subfamily A member 1	Homo sapiens	220-225
20460725-7	2010	We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.	piperine	125-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	210-215
20460725-7	2010	We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.	piperine	125-136	transient receptor potential cation channel subfamily A member 1	Homo sapiens	220-225
20460725-7	2010	We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.	piperine	138-150	transient receptor potential cation channel subfamily V member 1	Homo sapiens	210-215
20460725-7	2010	We identified in this study new transient receptor potential (TRP) agonists present in black pepper and found that piperine, isopiperine, isochavicine, piperanine, piperolein A, and piperolein B activated both TRPV1 and TRPA1.	piperine	138-150	transient receptor potential cation channel subfamily A member 1	Homo sapiens	220-225
19110999-3	2008	A significant decrease in the activities of antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in the testis was observed at 10 and 100 mg of piperine administration when compared with the controls.	piperine	193-201	catalase	Rattus norvegicus	86-94
19703367-10	2009	KEY FINDINGS: P-gp inhibitory activity of the aqueous extract was comparable with that of pure piperine (P &gt; 0.05) and was significantly higher than the alcoholic extract (P &lt; 0.05).	piperine	95-103	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	14-18
19703367-11	2009	Pure piperine and the aqueous extract exhibited significant P-gp inhibitory activity compared with control, which was irrespective of oral pretreatment dose and duration levels.	piperine	5-13	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	60-64
19222908-0	2009	Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model.	piperine	0-8	heart and neural crest derivatives expressed 2	Mus musculus	108-111
19222908-0	2009	Piperine inhibits eosinophil infiltration and airway hyperresponsiveness by suppressing T cell activity and Th2 cytokine production in the ovalbumin-induced asthma model.	piperine	0-8	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	139-148
19222908-5	2009	KEY FINDINGS: Piperine-treated groups had suppressed eosinophil infiltration, allergic airway inflammation and airway hyperresponsiveness, and these occurred by suppression of the production of interleukin-4, interleukin-5, immunoglobulin E and histamine.	piperine	14-22	interleukin 4	Mus musculus	194-207
19222908-5	2009	KEY FINDINGS: Piperine-treated groups had suppressed eosinophil infiltration, allergic airway inflammation and airway hyperresponsiveness, and these occurred by suppression of the production of interleukin-4, interleukin-5, immunoglobulin E and histamine.	piperine	14-22	interleukin 5	Mus musculus	209-222
19327174-0	2009	Anti-inflammatory and antiarthritic effects of piperine in human interleukin 1beta-stimulated fibroblast-like synoviocytes and in rat arthritis models.	piperine	47-55	interleukin 1 beta	Homo sapiens	65-82
19327174-2	2009	METHODS: The in vitro anti-inflammatory activity of piperine was tested on interleukin 1beta (IL1beta)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis.	piperine	52-60	interleukin 1 beta	Homo sapiens	75-92
19327174-2	2009	METHODS: The in vitro anti-inflammatory activity of piperine was tested on interleukin 1beta (IL1beta)-stimulated fibroblast-like synoviocytes derived form patients with rheumatoid arthritis.	piperine	52-60	interleukin 1 beta	Homo sapiens	94-101
19327174-7	2009	RESULTS: Piperine inhibited the expression of IL6 and MMP13 and reduced the production of PGE2 in a dose dependant manner at concentrations of 10 to 100 microg/ml.	piperine	9-17	interleukin 6	Rattus norvegicus	46-49
19327174-7	2009	RESULTS: Piperine inhibited the expression of IL6 and MMP13 and reduced the production of PGE2 in a dose dependant manner at concentrations of 10 to 100 microg/ml.	piperine	9-17	matrix metallopeptidase 13	Rattus norvegicus	54-59
19327174-9	2009	Piperine inhibited the migration of activator protein 1 (AP-1), but not nuclear factor (NF)kappaB, into the nucleus in IL1beta-treated synoviocytes.	piperine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	36-55
19327174-9	2009	Piperine inhibited the migration of activator protein 1 (AP-1), but not nuclear factor (NF)kappaB, into the nucleus in IL1beta-treated synoviocytes.	piperine	0-8	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-61
19327174-9	2009	Piperine inhibited the migration of activator protein 1 (AP-1), but not nuclear factor (NF)kappaB, into the nucleus in IL1beta-treated synoviocytes.	piperine	0-8	interleukin 1 beta	Rattus norvegicus	119-126
19110999-3	2008	A significant decrease in the activities of antioxidant enzymes superoxide dismutase, catalase, glutathione peroxidase, and glutathione reductase in the testis was observed at 10 and 100 mg of piperine administration when compared with the controls.	piperine	193-201	glutathione-disulfide reductase	Rattus norvegicus	124-145
19110999-6	2008	Immunofluorescence studies demonstrated a dose-dependent increase in caspase 3 and Fas protein in testicular germ cells after piperine treatment.	piperine	126-134	caspase 3	Rattus norvegicus	69-78
18417181-0	2008	In vitro and in vivo evaluation of the effects of piperine on P-gp function and expression.	piperine	50-58	phosphoglycolate phosphatase	Homo sapiens	62-66
18480186-0	2008	Curcuminoids inhibit multiple human cytochromes P450, UDP-glucuronosyltransferase, and sulfotransferase enzymes, whereas piperine is a relatively selective CYP3A4 inhibitor.	piperine	121-129	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	156-162
18480186-5	2008	Piperine was a relatively selective noncompetitive inhibitor of CYP3A (IC(50) 5.5 +/- 0.7 microM, K(i) = 5.4 +/- 0.3 microM) with less effect on other enzymes evaluated (IC(50) &gt; 29 microM).	piperine	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-69
18480186-6	2008	Curcuminoid extract and piperine inhibited recombinant CYP3A4 much more potently (by &gt;5-fold) than CYP3A5.	piperine	24-32	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	55-61
18480186-10	2008	administered curcuminoid/piperine combination is most likely to inhibit CYP3A, CYP2C9, UGT, and SULT metabolism within the intestinal mucosa.	piperine	25-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	72-77
18480186-10	2008	administered curcuminoid/piperine combination is most likely to inhibit CYP3A, CYP2C9, UGT, and SULT metabolism within the intestinal mucosa.	piperine	25-33	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	79-85
18480186-10	2008	administered curcuminoid/piperine combination is most likely to inhibit CYP3A, CYP2C9, UGT, and SULT metabolism within the intestinal mucosa.	piperine	25-33	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	87-90
18417181-2	2008	The purpose of the present study was to evaluate the effects of acute and prolonged piperine exposure on cellular P-gp expression and function in vitro and in vivo.	piperine	84-92	phosphoglycolate phosphatase	Homo sapiens	114-118
18417181-3	2008	Piperine at concentrations ranging from 10 to 100 microM, determined by MTT assay to be non-cytotoxic, was observed to inhibit P-gp mediated efflux transport of [(3)H]-digoxin across L-MDR1 and Caco-2 cell monolayers.	piperine	0-8	phosphoglycolate phosphatase	Homo sapiens	127-131
18417181-3	2008	Piperine at concentrations ranging from 10 to 100 microM, determined by MTT assay to be non-cytotoxic, was observed to inhibit P-gp mediated efflux transport of [(3)H]-digoxin across L-MDR1 and Caco-2 cell monolayers.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	185-189
18417181-5	2008	In contrast, prolonged (48 and 72 h) co-incubation of Caco-2 cell monolayers with piperine (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.	piperine	82-90	phosphoglycolate phosphatase	Homo sapiens	121-125
18417181-5	2008	In contrast, prolonged (48 and 72 h) co-incubation of Caco-2 cell monolayers with piperine (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.	piperine	82-90	phosphoglycolate phosphatase	Homo sapiens	172-176
18417181-5	2008	In contrast, prolonged (48 and 72 h) co-incubation of Caco-2 cell monolayers with piperine (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.	piperine	82-90	ATP binding cassette subfamily B member 1	Homo sapiens	189-193
18417181-7	2008	Peroral administration of piperine at the dose of 112 microg/kg body weight/day to male Wistar rats for 14 consecutive days also led to increased intestinal P-gp levels.	piperine	26-34	phosphoglycolate phosphatase	Rattus norvegicus	157-161
18520030-4	2008	Furthermore, piperine was found to inhibit both ACAT1 and ACAT2 isozymes to a similar extent (IC50: 16, 18 microM, respectively) in cell-based assays using ACAT1- or ACAT2-expressing cells.	piperine	13-21	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	48-53
18563347-1	2008	We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities.	piperine	33-41	monoamine oxidase A	Mus musculus	126-131
18563347-1	2008	We have previously reported that piperine, a known piperidine alkaloid from Piper longum, competitively inhibited mouse brain MAO-A and MAO-B activities.	piperine	33-41	monoamine oxidase B	Mus musculus	136-141
18520030-4	2008	Furthermore, piperine was found to inhibit both ACAT1 and ACAT2 isozymes to a similar extent (IC50: 16, 18 microM, respectively) in cell-based assays using ACAT1- or ACAT2-expressing cells.	piperine	13-21	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	58-63
18520030-4	2008	Furthermore, piperine was found to inhibit both ACAT1 and ACAT2 isozymes to a similar extent (IC50: 16, 18 microM, respectively) in cell-based assays using ACAT1- or ACAT2-expressing cells.	piperine	13-21	acetyl-Coenzyme A acetyltransferase 1	Mus musculus	156-161
18520030-4	2008	Furthermore, piperine was found to inhibit both ACAT1 and ACAT2 isozymes to a similar extent (IC50: 16, 18 microM, respectively) in cell-based assays using ACAT1- or ACAT2-expressing cells.	piperine	13-21	acetyl-Coenzyme A acetyltransferase 2	Mus musculus	166-171
18520030-5	2008	Thus, it was suggested that piperine inhibited macrophage ACAT to decrease CE synthesis, leading to a reduction of lipid droplets.	piperine	28-36	sterol O-acyltransferase 2	Mus musculus	58-62
17346695-12	2007	Whereas, TRPV1 agonists, capsaicin and piperine, inhibited gastric lesions induced by ethanol, 1% ammonia, and aspirin, but had less of an effect on 0.6 M HCl-induced gastric lesions.	piperine	39-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-14
18289853-4	2008	Furthermore, a principal amide constituent, piperine, dose-dependently inhibited increase in serum GPT and GOT levels at doses of 2.5-10 mg/kg (p.o.)	piperine	44-52	glutamic pyruvic transaminase, soluble	Mus musculus	99-102
17706638-8	2007	The oxidative stress markers markedly alter prior to a decline in mitochondrial membrane potential, caspase-3 activation and DNA degradation The splenic cell population was observed to change only at 18 h and the release of two cytokines was affected at 72 h. Addition of piperine in various concentrations (1, 10 and 50 microg/ml) ameliorated the above events.	piperine	272-280	caspase 3	Mus musculus	100-109
17764673-0	2007	Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation.	piperine	0-8	tumor necrosis factor	Homo sapiens	18-27
17764673-0	2007	Piperine inhibits TNF-alpha induced adhesion of neutrophils to endothelial monolayer through suppression of NF-kappaB and IkappaB kinase activation.	piperine	0-8	nuclear factor kappa B subunit 1	Homo sapiens	108-117
17764673-4	2007	The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e. ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1) and E-selectin as analyzed by cell-ELISA and confirmed by flow cytometry.	piperine	58-66	tumor necrosis factor	Homo sapiens	102-129
17764673-4	2007	The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e. ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1) and E-selectin as analyzed by cell-ELISA and confirmed by flow cytometry.	piperine	58-66	tumor necrosis factor	Homo sapiens	131-140
17764673-4	2007	The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e. ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1) and E-selectin as analyzed by cell-ELISA and confirmed by flow cytometry.	piperine	58-66	intercellular adhesion molecule 1	Homo sapiens	193-199
17764673-4	2007	The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e. ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1) and E-selectin as analyzed by cell-ELISA and confirmed by flow cytometry.	piperine	58-66	intercellular adhesion molecule 1	Homo sapiens	201-234
17764673-4	2007	The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e. ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1) and E-selectin as analyzed by cell-ELISA and confirmed by flow cytometry.	piperine	58-66	vascular cell adhesion molecule 1	Homo sapiens	237-243
17764673-4	2007	The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e. ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1) and E-selectin as analyzed by cell-ELISA and confirmed by flow cytometry.	piperine	58-66	vascular cell adhesion molecule 1	Homo sapiens	245-278
17764673-4	2007	The inhibition of neutrophils to endothelial monolayer by piperine is due to its ability to block the tumor necrosis factor-alpha (TNF-alpha) induced expression of cell adhesion molecules i.e. ICAM-1 (intercellular adhesion molecule-1), VCAM-1 (vascular cell adhesion molecule-1) and E-selectin as analyzed by cell-ELISA and confirmed by flow cytometry.	piperine	58-66	selectin E	Homo sapiens	284-294
17764673-5	2007	Further, we demonstrate that inhibition of ICAM-1 by piperine is reversible.	piperine	53-61	intercellular adhesion molecule 1	Homo sapiens	43-49
17764673-6	2007	As nuclear factor-kappaB (NF-kappaB) is known to control the transcriptional regulation of cell adhesion molecules hence, we measured the effect of piperine on NF-kappaB in the cytoplasm and in the nucleus of endothelial cells.	piperine	148-156	nuclear factor kappa B subunit 1	Homo sapiens	3-24
17764673-6	2007	As nuclear factor-kappaB (NF-kappaB) is known to control the transcriptional regulation of cell adhesion molecules hence, we measured the effect of piperine on NF-kappaB in the cytoplasm and in the nucleus of endothelial cells.	piperine	148-156	nuclear factor kappa B subunit 1	Homo sapiens	26-35
17764673-6	2007	As nuclear factor-kappaB (NF-kappaB) is known to control the transcriptional regulation of cell adhesion molecules hence, we measured the effect of piperine on NF-kappaB in the cytoplasm and in the nucleus of endothelial cells.	piperine	148-156	nuclear factor kappa B subunit 1	Homo sapiens	160-169
17764673-7	2007	We observed that pretreatment of endothelial cells with piperine blocks the nuclear translocation and activation of NF-kappaB via blocking the phosphorylation and degradation of its inhibitory protein, IkappaBalpha.	piperine	56-64	nuclear factor kappa B subunit 1	Homo sapiens	116-125
17764673-7	2007	We observed that pretreatment of endothelial cells with piperine blocks the nuclear translocation and activation of NF-kappaB via blocking the phosphorylation and degradation of its inhibitory protein, IkappaBalpha.	piperine	56-64	NFKB inhibitor alpha	Homo sapiens	202-214
17764673-8	2007	Piperine blocks the phosphorylation and degradation of IkappaBalpha by attenuating TNF-alpha induced IkappaB kinase activity.	piperine	0-8	NFKB inhibitor alpha	Homo sapiens	55-67
17764673-8	2007	Piperine blocks the phosphorylation and degradation of IkappaBalpha by attenuating TNF-alpha induced IkappaB kinase activity.	piperine	0-8	tumor necrosis factor	Homo sapiens	83-92
17418561-0	2007	Piperine protects cisplatin-induced apoptosis via heme oxygenase-1 induction in auditory cells.	piperine	0-8	heme oxygenase 1	Homo sapiens	50-66
17418561-2	2007	In this study, we examined whether piperine could protect House Ear Institute-Organ of Corti 1 (HEI-OC1) cells against cisplatin-induced apoptosis through the induction of heme oxygenase (HO)-1 expression.	piperine	35-43	heme oxygenase 1	Homo sapiens	172-193
17418561-3	2007	Piperine (10-100 microM) induced the expression of HO-1 in dose- and time-dependent manners.	piperine	0-8	heme oxygenase 1	Homo sapiens	51-55
17418561-4	2007	Piperine also induced antioxidant response element-luciferase and translocated nuclear factor-E2-related factor-2 (Nrf2) to nucleus.	piperine	0-8	NFE2 like bZIP transcription factor 2	Homo sapiens	115-119
17418561-5	2007	Piperine activated the c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (MAPK) pathways, and the JNK pathway played an important role in piperine-induced HO-1 expression.	piperine	0-8	mitogen-activated protein kinase 8	Homo sapiens	23-46
17418561-5	2007	Piperine activated the c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (MAPK) pathways, and the JNK pathway played an important role in piperine-induced HO-1 expression.	piperine	0-8	mitogen-activated protein kinase 8	Homo sapiens	48-51
17418561-5	2007	Piperine activated the c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (MAPK) pathways, and the JNK pathway played an important role in piperine-induced HO-1 expression.	piperine	0-8	mitogen-activated protein kinase 14	Homo sapiens	96-132
17418561-5	2007	Piperine activated the c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (MAPK) pathways, and the JNK pathway played an important role in piperine-induced HO-1 expression.	piperine	0-8	heme oxygenase 1	Homo sapiens	215-219
17418561-5	2007	Piperine activated the c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (MAPK) pathways, and the JNK pathway played an important role in piperine-induced HO-1 expression.	piperine	198-206	mitogen-activated protein kinase 8	Homo sapiens	158-161
17418561-5	2007	Piperine activated the c-Jun N-terminal kinase (JNK), extracellular signal-regulated kinase and p38 mitogen-activated protein kinase (MAPK) pathways, and the JNK pathway played an important role in piperine-induced HO-1 expression.	piperine	198-206	heme oxygenase 1	Homo sapiens	215-219
17418561-7	2007	The protective effect of piperine was abrogated by zinc protoporphyrin IX, an HO inhibitor, and antisense oligodeoxynucleotides against HO-1 gene.	piperine	25-33	heme oxygenase 1	Homo sapiens	136-140
17418561-8	2007	These results demonstrate that the expression of HO-1 by piperine is mediated by both JNK pathway and Nrf2, and the expression inhibits cisplatin-induced apoptosis in HEI-OC1 cells.	piperine	57-65	heme oxygenase 1	Homo sapiens	49-53
17418561-8	2007	These results demonstrate that the expression of HO-1 by piperine is mediated by both JNK pathway and Nrf2, and the expression inhibits cisplatin-induced apoptosis in HEI-OC1 cells.	piperine	57-65	mitogen-activated protein kinase 8	Homo sapiens	86-89
17418561-8	2007	These results demonstrate that the expression of HO-1 by piperine is mediated by both JNK pathway and Nrf2, and the expression inhibits cisplatin-induced apoptosis in HEI-OC1 cells.	piperine	57-65	NFE2 like bZIP transcription factor 2	Homo sapiens	102-106
17156774-9	2007	Taken together, the results suggest that piperine inhibits the vagally mediated striated muscle contraction in the mouse esophagus through its action on a TRPV1-dependent pathway as well as a TRPV1-independent site.	piperine	41-49	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	155-160
17289085-3	2007	Furthermore, the decreased proliferation of hippocampal progenitor cells was ameliorated and the level of brain-derived neurotrophic factor (BDNF) in hippocampus of CMS stressed mice was up-regulated by piperine treatment in the same time course.	piperine	203-211	brain derived neurotrophic factor	Mus musculus	106-139
17289085-3	2007	Furthermore, the decreased proliferation of hippocampal progenitor cells was ameliorated and the level of brain-derived neurotrophic factor (BDNF) in hippocampus of CMS stressed mice was up-regulated by piperine treatment in the same time course.	piperine	203-211	brain derived neurotrophic factor	Mus musculus	141-145
17289085-6	2007	Treatment with piperine (6.25-25 microM) for 72 h reversed the CORT-induced reduction of BDNF mRNA expression in cultured hippocampal neurons.	piperine	15-23	brain derived neurotrophic factor	Mus musculus	89-93
17289085-7	2007	In summary, up-regulation of the progenitor cell proliferation of hippocampus and cytoprotective activity might be mechanisms involved in the antidepressant-like effect of piperine, which may be closely related to the elevation of hippocampal BDNF level.	piperine	172-180	brain derived neurotrophic factor	Mus musculus	243-247
17156774-2	2007	In a recent study, similar but also different effects of capsaicin and piperine on TRPV1 were demonstrated.	piperine	71-79	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	83-88
17156774-9	2007	Taken together, the results suggest that piperine inhibits the vagally mediated striated muscle contraction in the mouse esophagus through its action on a TRPV1-dependent pathway as well as a TRPV1-independent site.	piperine	41-49	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	192-197
16366712-0	2005	Binding of the pepper alkaloid piperine to bovine beta-lactoglobulin: circular dichroism spectroscopy and molecular modeling study.	piperine	31-39	beta-lactoglobulin	Bos taurus	50-68
16624279-6	2006	Piperine at low concentrations may reduce the MPP(+)-induced viability loss in PC12 cells by suppressing the changes in the mitochondrial membrane permeability, leading to the release of cytochrome c and subsequent activation of caspase-3.	piperine	0-8	caspase 3	Rattus norvegicus	229-238
17266134-0	2007	TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist.	piperine	106-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
17266134-0	2007	TRPV1 is involved in stretch-evoked contractile changes in the rat autonomous bladder model: a study with piperine, a new TRPV1 agonist.	piperine	106-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	122-127
17266134-3	2007	In this study, we looked at PIP-effects on autonomous bladder contractile activity, with particular interest for its selectivity for the transient receptor potential channel 1 (TRPV1) receptor.	piperine	28-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	177-182
17266134-14	2007	CONCLUSION: We found evidence for acute and prolonged effects of PIP on bladder contractility, which seem to be mediated through TRPV1.	piperine	65-68	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	129-134
16366712-4	2005	Induced CD spectra measured in pH 7.7 phosphate buffer at 37 degrees C demonstrated reversible, non-covalent association of piperine with bovine beta-lactoglobulin (BLG), the major whey protein in milk.	piperine	124-132	beta-lactoglobulin	Bos taurus	145-163
16366712-4	2005	Induced CD spectra measured in pH 7.7 phosphate buffer at 37 degrees C demonstrated reversible, non-covalent association of piperine with bovine beta-lactoglobulin (BLG), the major whey protein in milk.	piperine	124-132	beta-lactoglobulin	Bos taurus	165-168
16366712-8	2005	Molecular docking calculations showed that piperine can be efficiently accommodated within the calyx of BLG.	piperine	43-51	beta-lactoglobulin	Bos taurus	104-107
16366712-9	2005	Additional molecular modeling calculations indicated that the beta-barrel of human tear lipocalin, human serum retinol binding protein, and human neutrophil gelatinase associated lipocalin might also accommodate a piperine molecule.	piperine	214-222	lipocalin 2	Homo sapiens	146-188
16313198-3	2005	Both compounds 1 and 2 inhibited the TNF-alpha-induced expression of ICAM-1 in a dose- and time-dependent manner; however, the activity of ethyl 3",4",5"-trimethoxycinnamate (1) was approximately 1.3 times higher than that of piperine (2).	piperine	226-234	tumor necrosis factor	Homo sapiens	37-46
16043235-3	2005	A recent study shows that piperine, the irritant principle in black pepper, is more efficient than capsaicin in the desensitization of human TRPV1, which suggests that this pharmacological aspect of vanilloids can be dissociated from its potency.	piperine	26-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	141-146
16043235-4	2005	This finding raises the intriguing possibility that piperine can be used as a chemical template for the design of improved TRPV1 agonists.	piperine	52-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	123-128
15685214-0	2005	Effects of piperine, the pungent component of black pepper, at the human vanilloid receptor (TRPV1).	piperine	11-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-98
15685214-2	2005	We have characterised the effects of piperine, a pungent alkaloid found in black pepper, on the human vanilloid receptor TRPV1 using whole-cell patch-clamp electrophysiology.	piperine	37-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-126
15685214-4	2005	Piperine produced a clear agonist activity at the human TRPV1 receptor yielding rapidly activating whole-cell currents that were antagonised by the competitive TRPV1 antagonist capsazepine and the non-competitive TRPV1 blocker ruthenium red.	piperine	0-8	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
15685214-4	2005	Piperine produced a clear agonist activity at the human TRPV1 receptor yielding rapidly activating whole-cell currents that were antagonised by the competitive TRPV1 antagonist capsazepine and the non-competitive TRPV1 blocker ruthenium red.	piperine	0-8	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-165
15685214-4	2005	Piperine produced a clear agonist activity at the human TRPV1 receptor yielding rapidly activating whole-cell currents that were antagonised by the competitive TRPV1 antagonist capsazepine and the non-competitive TRPV1 blocker ruthenium red.	piperine	0-8	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-165
15685214-6	2005	The current-voltage relationship of piperine-activated currents showed pronounced outward rectification (25+/-4-fold between -70 and +70 mV) and a reversal potential of 0.0+/-0.4 mV, which was indistinguishable from that of the prototypical TRPV1 agonist capsaicin.	piperine	36-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	241-246
15685214-8	2005	Although piperine was a less potent agonist (EC50=37.9+/-1.9 microM) than capsaicin (EC50=0.29+/-0.05 microM), it demonstrated a much greater efficacy (approximately two-fold) at TRPV1.	piperine	9-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	179-184
15685214-14	2005	Overall, our data suggest that the effects of piperine at human TRPV1 are similar to those of capsaicin except for its propensity to induce greater receptor desensitisation and, rather remarkably, exhibit a greater efficacy than capsaicin itself.	piperine	46-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-69
15685214-15	2005	These results may provide insight into the TRPV1-mediated effects of piperine on gastrointestinal function.	piperine	69-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	piperine	24-32	ATP binding cassette subfamily B member 1	Homo sapiens	128-131
15531295-0	2004	Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells.	piperine	0-8	FBJ osteosarcoma oncogene	Mus musculus	69-74
15531295-0	2004	Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells.	piperine	0-8	cAMP responsive element binding protein 1	Mus musculus	76-80
15531295-0	2004	Piperine is a potent inhibitor of nuclear factor-kappaB (NF-kappaB), c-Fos, CREB, ATF-2 and proinflammatory cytokine gene expression in B16F-10 melanoma cells.	piperine	0-8	activating transcription factor 2	Mus musculus	82-87
15531295-4	2004	We also found that piperine could reduce the expression of IL-1beta, IL-6, TNF-alpha, GM-CSF and IL-12p40 genes.	piperine	19-27	interleukin 1 beta	Mus musculus	59-67
15531295-4	2004	We also found that piperine could reduce the expression of IL-1beta, IL-6, TNF-alpha, GM-CSF and IL-12p40 genes.	piperine	19-27	interleukin 6	Mus musculus	69-73
15531295-4	2004	We also found that piperine could reduce the expression of IL-1beta, IL-6, TNF-alpha, GM-CSF and IL-12p40 genes.	piperine	19-27	tumor necrosis factor	Mus musculus	75-84
15531295-4	2004	We also found that piperine could reduce the expression of IL-1beta, IL-6, TNF-alpha, GM-CSF and IL-12p40 genes.	piperine	19-27	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	86-92
15531295-4	2004	We also found that piperine could reduce the expression of IL-1beta, IL-6, TNF-alpha, GM-CSF and IL-12p40 genes.	piperine	19-27	interleukin 12b	Mus musculus	97-105
15531295-7	2004	We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine.	piperine	178-186	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	43-46
15531295-7	2004	We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine.	piperine	178-186	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	48-51
15531295-7	2004	We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine.	piperine	178-186	reticuloendotheliosis oncogene	Mus musculus	53-58
15531295-7	2004	We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine.	piperine	178-186	activating transcription factor 2	Mus musculus	121-126
15531295-7	2004	We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine.	piperine	178-186	FBJ osteosarcoma oncogene	Mus musculus	128-133
15531295-7	2004	We found that the nuclear translocation of p65, p50, c-Rel subunits of NF-kappaB and other transcription factors such as ATF-2, c-Fos and CREB were inhibited by the treatment of piperine.	piperine	178-186	cAMP responsive element binding protein 1	Mus musculus	138-142
15120460-2	2004	Among these compounds, piperine and paeonol were found to be inhibitory against MAO A in a dose-dependent manner with IC(50) values of 49.3 and 54.6 microM, respectively.	piperine	23-31	monoamine oxidase A	Rattus norvegicus	80-85
15120460-3	2004	Piperine, paeonol and emodin were shown to inhibit MAO B in a dose-dependent manner with the IC(50) data of 91.3, 42.5 and 35.4 microM, respectively.	piperine	0-8	monoamine oxidase B	Rattus norvegicus	51-56
15120460-4	2004	Lineweaver-Burk transformation of the inhibition data indicated that the inhibitory action of piperine on MAO A was of mixed type, and that of paeonol on the same type of the enzyme was of non-competitive type.	piperine	94-102	monoamine oxidase A	Rattus norvegicus	106-111
15120460-7	2004	The inhibition of piperine and paeonol on MAO B was of competitive type with K(i) values of 79.9 and 38.2 microM, respectively.	piperine	18-26	monoamine oxidase B	Rattus norvegicus	42-47
15120460-9	2004	The present investigation showed that the phytochemicals piperine, paeonol and emodin are potent MAO inhibitors whereas other compounds were inactive against any type of MAO at 100 microM in the present assay.	piperine	57-65	monoamine oxidase A	Rattus norvegicus	97-100
15881660-5	2005	Piperine supplementation to tumour-induced animals significantly lowered the phase-I enzymes (NADPH-C reductase, cyt-p450 and cyt-b5)) and there was a rise in glutathione-metabolizing enzymes (GPx, GR and G6PDH), which indicated an antitumour and anti-cancer effect.	piperine	0-8	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	113-121
15881660-5	2005	Piperine supplementation to tumour-induced animals significantly lowered the phase-I enzymes (NADPH-C reductase, cyt-p450 and cyt-b5)) and there was a rise in glutathione-metabolizing enzymes (GPx, GR and G6PDH), which indicated an antitumour and anti-cancer effect.	piperine	0-8	peroxiredoxin 6 pseudogene 2	Mus musculus	193-196
15881660-5	2005	Piperine supplementation to tumour-induced animals significantly lowered the phase-I enzymes (NADPH-C reductase, cyt-p450 and cyt-b5)) and there was a rise in glutathione-metabolizing enzymes (GPx, GR and G6PDH), which indicated an antitumour and anti-cancer effect.	piperine	0-8	glutathione reductase	Mus musculus	198-200
16292757-5	2005	Piperine showed slight down-regulation of the UGDH gene expression, whereas no effect was observed with acetaminophen treatment.	piperine	0-8	UDP-glucose 6-dehydrogenase	Homo sapiens	46-50
15183854-2	2004	To evaluate the effects of orally supplemented piperine on lung tumour initiation by B(a)p, its effects on ATPase enzymes were first evaluated.	piperine	47-55	dynein, axonemal, heavy chain 8	Mus musculus	107-113
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	piperine	24-32	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
15072439-5	2004	Curcumin, ginsenosides, piperine, some catechins from green tea, and silymarin from milk thistle were found to be inhibitors of Pgp, while some catechins from green tea increased Pgp-mediated drug transport by heterotropic allosteric mechanism, and St. John"s wort induced the intestinal expression of Pgp in vitro and in vivo.	piperine	24-32	ATP binding cassette subfamily B member 1	Homo sapiens	179-182
11083086-3	2000	Piperine treatment of normal rats enhanced hepatic GSSG concentration by 100% and decreased renal GSH concentration by 35% and renal glutathione reductase activity by 25% when compared to normal controls.	piperine	0-8	glutathione-disulfide reductase	Rattus norvegicus	133-154
15231065-5	2004	Simultaneous supplementation with black pepper or piperine lowered TBARS and CD levels and maintained SOD, CAT, GPx, GST, and GSH levels to near those of control rats.	piperine	50-58	catalase	Rattus norvegicus	107-110
15231065-5	2004	Simultaneous supplementation with black pepper or piperine lowered TBARS and CD levels and maintained SOD, CAT, GPx, GST, and GSH levels to near those of control rats.	piperine	50-58	hematopoietic prostaglandin D synthase	Rattus norvegicus	117-120
14646185-4	2003	Among them, flavones, flavonols, anthraquinones, piperine, coumestrol, brevifolincarboxylic acid, and resveratrol showed marked inhibitory effects on AhR-based bioassay activation by TCDD, and their effects were dose dependent.	piperine	49-57	aryl hydrocarbon receptor	Homo sapiens	150-153
12806184-6	2003	Preincubating GEC with CYP2B1 inhibitors (piperine and cimetidine) and H(2)O(2) scavenger (pyruvate) significantly reduced H(2)O(2 )generation, preserved CYP2B1 content, prevented the increase in catalytic iron and hydroxyl radical formation including PAN-induced cytotoxicity.	piperine	42-50	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	23-29
12806184-6	2003	Preincubating GEC with CYP2B1 inhibitors (piperine and cimetidine) and H(2)O(2) scavenger (pyruvate) significantly reduced H(2)O(2 )generation, preserved CYP2B1 content, prevented the increase in catalytic iron and hydroxyl radical formation including PAN-induced cytotoxicity.	piperine	42-50	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	154-160
12130727-0	2002	Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.	piperine	0-8	ATP binding cassette subfamily B member 1	Homo sapiens	62-76
12130727-0	2002	Piperine, a major constituent of black pepper, inhibits human P-glycoprotein and CYP3A4.	piperine	0-8	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	81-87
12130727-3	2002	Preliminary data indicate that piperine, a major component of black pepper, inhibits drug-metabolizing enzymes in rodents and increases plasma concentrations of several drugs, including P-glycoprotein substrates (phenytoin and rifampin) in humans.	piperine	31-39	ATP binding cassette subfamily B member 1	Homo sapiens	186-200
12130727-5	2002	We therefore investigated the influence of piperine on P-glycoprotein-mediated, polarized transport of digoxin and cyclosporine in monolayers of Caco-2 cells.	piperine	43-51	ATP binding cassette subfamily B member 1	Homo sapiens	55-69
12130727-6	2002	Moreover, by using human liver microsomes we determined the effect of piperine on CYP3A4-mediated formation of the verapamil metabolites D-617 and norverapamil.	piperine	70-78	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
12130727-9	2002	In summary, we showed that piperine inhibits both the drug transporter P-glycoprotein and the major drug-metabolizing enzyme CYP3A4.	piperine	27-35	ATP binding cassette subfamily B member 1	Homo sapiens	71-85
12130727-9	2002	In summary, we showed that piperine inhibits both the drug transporter P-glycoprotein and the major drug-metabolizing enzyme CYP3A4.	piperine	27-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	125-131
12130727-10	2002	Because both proteins are expressed in enterocytes and hepatocytes and contribute to a major extent to first-pass elimination of many drugs, our data indicate that dietary piperine could affect plasma concentrations of P-glycoprotein and CYP3A4 substrates in humans, in particular if these drugs are administered orally.	piperine	172-180	ATP binding cassette subfamily B member 1	Homo sapiens	219-233
12130727-10	2002	Because both proteins are expressed in enterocytes and hepatocytes and contribute to a major extent to first-pass elimination of many drugs, our data indicate that dietary piperine could affect plasma concentrations of P-glycoprotein and CYP3A4 substrates in humans, in particular if these drugs are administered orally.	piperine	172-180	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	238-244
11595435-6	2001	(2) VR-1 agonists (capsaicin, resiniferatoxin, piperine) protect against gastric ulcer of the rat parallel with their sensory stimulating potencies.	piperine	47-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-8
10968285-0	2000	Structure-activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities.	piperine	35-43	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	157-172
10968285-2	2000	We have reported earlier that piperine, a major alkaloid of black and long peppers inhibits both constitutive and inducible cytochrome P450 (CYP)-dependent drug metabolising enzymes.	piperine	30-38	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	124-139
10968285-2	2000	We have reported earlier that piperine, a major alkaloid of black and long peppers inhibits both constitutive and inducible cytochrome P450 (CYP)-dependent drug metabolising enzymes.	piperine	30-38	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	141-144
14971727-4	2004	Oral supplementation of piperine (50 mg/kg body weight) effectively suppressed lung carcinogenesis in B(a)p induced mice as revealed by the decrease in the extent of mitochondrial lipid peroxidation and concomitant increase in the activities of enzymatic antioxidants (superoxide dismutase, catalase and glutathione peroxidase) and non enzymatic antioxidant (reduced glutathione, vitamin E and vitamin C) levels when compared to lung carcinogenesis bearing animals.	piperine	24-32	catalase	Mus musculus	291-299
19180797-0	2003	Effect of piperine on the inhibition of nitric oxide (NO) and TNF-alpha production.	piperine	10-18	tumor necrosis factor	Mus musculus	62-71
19180797-1	2003	Effect of piperine which is an alkaloid present in plants such as Piper nigrum and Piper longum on the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-alpha) level was analyzed using in vitro as well as in vivo systems.	piperine	10-18	tumor necrosis factor	Mus musculus	168-177
19180797-4	2003	The drastically elevated levels of TNF-alpha in the lipopolysaccharide (LPS) stimulated animals (625.8 pg/mL) was lowered in the piperine treated animals (105.8 pg/mL).	piperine	129-137	tumor necrosis factor	Mus musculus	35-44
19180797-5	2003	Piperine also inhibited the Con-A induced TNF-alpha production.	piperine	0-8	tumor necrosis factor	Mus musculus	42-51
19180797-7	2003	In vitro L929 bioassay also revealed the inhibition of TNF-alpha production by the piperine treatment.	piperine	83-91	tumor necrosis factor	Mus musculus	55-64
12164868-9	2002	CYP2B1 inhibitors cimetidine and piperine significantly reduced H2O2 generation, and prevented the loss of CYP2B1 content and the increase in the catalytic iron.	piperine	33-41	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	0-6
12164868-9	2002	CYP2B1 inhibitors cimetidine and piperine significantly reduced H2O2 generation, and prevented the loss of CYP2B1 content and the increase in the catalytic iron.	piperine	33-41	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	107-113
11083086-5	2000	Treatment with piperine reversed the diabetic effects on GSSG concentration in brain, on renal glutathione peroxidase and superoxide dismutase activities, and on cardiac glutathione reductase activity and lipid peroxidation.	piperine	15-23	glutathione-disulfide reductase	Rattus norvegicus	170-191
8561796-1	1996	Modulation of benzo(a)pyrene (BP) metabolism and regulation of CYP1A1 gene expression by piperine in 5L cells in culture was studied.	piperine	89-97	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	63-69
8561796-3	1996	Exposure of cell cultures to piperine for 24 h indicated activation of CYP1A1 gene transcription.	piperine	29-37	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	71-77
8561796-5	1996	Combined treatment with BA plus piperine further increased CYP1A1mRNA contents by about 25%.	piperine	32-40	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	59-65
8561796-10	1996	The results, suggest that piperine mediated inhibition of the AHH activity and consequent suppression of the procarcinogen activation is the result of direct interaction of piperine with CYP1A1-protein and not because of down regulation of the CYP1A1 gene expression.	piperine	26-34	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	62-65
8561796-10	1996	The results, suggest that piperine mediated inhibition of the AHH activity and consequent suppression of the procarcinogen activation is the result of direct interaction of piperine with CYP1A1-protein and not because of down regulation of the CYP1A1 gene expression.	piperine	26-34	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	187-193
8561796-10	1996	The results, suggest that piperine mediated inhibition of the AHH activity and consequent suppression of the procarcinogen activation is the result of direct interaction of piperine with CYP1A1-protein and not because of down regulation of the CYP1A1 gene expression.	piperine	173-181	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	62-65
8561796-10	1996	The results, suggest that piperine mediated inhibition of the AHH activity and consequent suppression of the procarcinogen activation is the result of direct interaction of piperine with CYP1A1-protein and not because of down regulation of the CYP1A1 gene expression.	piperine	173-181	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	187-193
8347144-0	1993	Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine.	piperine	134-142	UDP-glucose 6-dehydrogenase	Rattus norvegicus	14-39
8586024-1	1995	The effect of piperine on CCl4-induced hepatotoxicity was investigated in rats.	piperine	14-22	C-C motif chemokine ligand 4	Rattus norvegicus	26-30
8586024-2	1995	Piperine pretreatment potentiated the hepatotoxicity of CCl4 in a dose-dependent manner.	piperine	0-8	C-C motif chemokine ligand 4	Rattus norvegicus	56-60
8586024-3	1995	The maximum potentiation occurred when piperine at a dose of 100 mg/kg BW was intragastrically administered 4 h prior to an intraperitoneal injection of CCl4, at which time the activities of plasma glutamic pyruvic transaminase (PGPT) and plasma glutamic oxaloacetic transaminase (PGOT) were elevated by 70-80%.	piperine	39-47	C-C motif chemokine ligand 4	Rattus norvegicus	153-157
8586024-5	1995	Piperine pretreatment also potentiated CCl4-induced lipid peroxidation in the liver.	piperine	0-8	C-C motif chemokine ligand 4	Rattus norvegicus	39-43
8586024-7	1995	In the in vitro system in which the tissue was preincubated with piperine and CCl4 was added into the incubation medium, piperine also exhibited a concentration dependent potentiation on CCl4-induced lipid peroxidation and on the activity of NADPH-cytochrome c-reductase.	piperine	65-73	C-C motif chemokine ligand 4	Rattus norvegicus	187-191
8586024-7	1995	In the in vitro system in which the tissue was preincubated with piperine and CCl4 was added into the incubation medium, piperine also exhibited a concentration dependent potentiation on CCl4-induced lipid peroxidation and on the activity of NADPH-cytochrome c-reductase.	piperine	121-129	C-C motif chemokine ligand 4	Rattus norvegicus	78-82
8586024-7	1995	In the in vitro system in which the tissue was preincubated with piperine and CCl4 was added into the incubation medium, piperine also exhibited a concentration dependent potentiation on CCl4-induced lipid peroxidation and on the activity of NADPH-cytochrome c-reductase.	piperine	121-129	C-C motif chemokine ligand 4	Rattus norvegicus	187-191
8586024-8	1995	The results indicated that piperine potentiated CCl4-induced hepatotoxicity by interacting with liver cells and increased the activity of NADPH-cytochrome c reductase.	piperine	27-35	C-C motif chemokine ligand 4	Rattus norvegicus	48-52
8347144-1	1993	The effects of piperine, a major ingredient of black pepper, on UDP-glucose dehydrogenase (UDP-GDH) and glucuronidation potentials of rat and guinea pig liver and intestine were studied.	piperine	15-23	UDP-glucose 6-dehydrogenase	Rattus norvegicus	64-89
8347144-1	1993	The effects of piperine, a major ingredient of black pepper, on UDP-glucose dehydrogenase (UDP-GDH) and glucuronidation potentials of rat and guinea pig liver and intestine were studied.	piperine	15-23	UDP-glucose 6-dehydrogenase	Rattus norvegicus	91-98
8347144-2	1993	Piperine caused a concentration-related strong inhibition of UDP-GDH (50% at 10 microM) reversibly and equipotently, in both tissues.	piperine	0-8	UDP-glucose 6-dehydrogenase	Rattus norvegicus	61-68
8347144-14	1993	In guinea pig small intestine, both these activities were inhibited significantly requiring less than 25 microM piperine to produce a more than 50% inhibition of UGT(s).	piperine	112-120	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	162-165
8347144-15	1993	The results suggested that (i) piperine is a potent inhibitor of UDP-GDH, (ii) inhibition is offered exclusively by the conjugated double bonds of the molecule, and (iii) piperine exerts stronger effects on intestinal glucuronidation than in rat liver.	piperine	31-39	UDP-glucose 6-dehydrogenase	Rattus norvegicus	65-72
1889831-2	1991	In vitro piperine caused concentration related inhibition (50% at 100 microM) of arylhydrocarbon hydroxylase (AHH) and 7-ethoxycourmarin deethylase (7ECDE) activities, which were comparable in control and 3-methylcholanthrene (3MC) treated rats.	piperine	9-17	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	110-113
1348936-3	1992	In vitro experiments showed that piperine (25-100 microM) significantly stimulated gamma-glutamyl transpeptidase (gamma-GT, EC 2.3.2.2.)	piperine	33-41	gamma-glutamyltransferase 1	Rattus norvegicus	83-112
1348936-3	1992	In vitro experiments showed that piperine (25-100 microM) significantly stimulated gamma-glutamyl transpeptidase (gamma-GT, EC 2.3.2.2.)	piperine	33-41	gamma-glutamyltransferase 1	Rattus norvegicus	114-122
1348936-5	1992	The kinetic behaviour of gamma-GT towards substrate and acceptor altered in the presence of piperine.	piperine	92-100	gamma-glutamyltransferase 1	Rattus norvegicus	25-33
1348936-6	1992	In the presence of benzyl alcohol, an enhanced gamma-GT activity due to piperine was maintained.	piperine	72-80	gamma-glutamyltransferase 1	Rattus norvegicus	47-55
1889831-7	1991	Similarly, upon daily treatment of piperine (15 mg/kg body wt) to rats for 7 days, 7ECDE was consistently inhibited, while AHH showed faster recovery.	piperine	35-43	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	123-126
33771600-6	2021	Further, BPME and piperine (the major bioactive alkaloid of black pepper) significantly downregulated hepcidin protein expression at 200 mug/ml and 100 muM concentrations, respectively.	piperine	18-26	hepcidin antimicrobial peptide	Homo sapiens	102-110
1889377-2	1991	administration of rats with piperine (100 mg/kg) and piperonyl butoxide (400 mg/kg) produced a significant decrease in hepatic cytochrome P-450, and activities of benzphetamine N-demethylase, aminopyrine N-demethylase and aniline hydroxylase 1 hr after the treatment.	piperine	28-36	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	127-143
1893751-2	1991	An intragastric dose of 100 mg/kg of piperine to adult, male Sprague-Dawley rats caused an increase in hepatic microsomal cytochrome P-450 and cytochrome b5, NADPH-cytochrome c reductase, benzphetamine N-demethylase, aminopyrine N-demethylase and aniline hydroxylase 24 h following treatment.	piperine	37-45	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	122-138
1893751-2	1991	An intragastric dose of 100 mg/kg of piperine to adult, male Sprague-Dawley rats caused an increase in hepatic microsomal cytochrome P-450 and cytochrome b5, NADPH-cytochrome c reductase, benzphetamine N-demethylase, aminopyrine N-demethylase and aniline hydroxylase 24 h following treatment.	piperine	37-45	cytochrome b5 type A	Rattus norvegicus	143-156
33771600-7	2021	In the next phase, BPME and piperine were found to significantly attenuate the BMP-6 and IL-6 induced hepcidin overexpression by downregulating the increased level of pSMAD1 and pSTAT3 proteins.	piperine	28-36	bone morphogenetic protein 6	Mus musculus	79-84
33771600-7	2021	In the next phase, BPME and piperine were found to significantly attenuate the BMP-6 and IL-6 induced hepcidin overexpression by downregulating the increased level of pSMAD1 and pSTAT3 proteins.	piperine	28-36	interleukin 6	Mus musculus	89-93
33771600-7	2021	In the next phase, BPME and piperine were found to significantly attenuate the BMP-6 and IL-6 induced hepcidin overexpression by downregulating the increased level of pSMAD1 and pSTAT3 proteins.	piperine	28-36	hepcidin antimicrobial peptide	Homo sapiens	102-110
33771600-9	2021	After that, the intraperitoneal administration of BPME and piperine at 70 and 25 mg/kg body weight, respectively, on alternate days for a period of another two weeks resulted in downregulation of hepcidin overexpression in diseased mice, as confirmed by RT-PCR and immunoblot analysis.	piperine	59-67	hepcidin antimicrobial peptide	Mus musculus	196-204
33771600-11	2021	The molecular docking-based interaction studies demonstrated the binding potential of piperine with SMAD1 and STAT3 proteins.	piperine	86-94	SMAD family member 1	Mus musculus	100-105
33771600-11	2021	The molecular docking-based interaction studies demonstrated the binding potential of piperine with SMAD1 and STAT3 proteins.	piperine	86-94	signal transducer and activator of transcription 3	Mus musculus	110-115
33682565-3	2021	Herein, using a high-throughput screening approach based on enzymic activity of CYP2J2, we rapidly and effectively identified a novel natural inhibitor (Piperine, 9a) with IC50 value of 0.44 muM from 108 common herbal medicines.	piperine	153-161	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	80-86
34751064-0	2021	Synergistic effect of ursolic acid and piperine in CCl4 induced hepatotoxicity.	piperine	39-47	C-C motif chemokine ligand 4	Rattus norvegicus	51-55
34905918-4	2021	Piperine treatment significantly inhibited leptin-induced breast cancer cell proliferation, colony formation, migration, and invasion.	piperine	0-8	leptin	Mus musculus	43-49
34905918-5	2021	We found that piperine downregulated the expression of PPARalpha, a predicted target of miR-181c-3p.	piperine	14-22	peroxisome proliferator activated receptor alpha	Mus musculus	55-64
34905918-6	2021	Mechanistically, piperine potentiates miR-181c-3p-mediated anticancer potential in leptin-induced breast cancer cells.	piperine	17-25	leptin	Mus musculus	83-89
34905918-8	2021	Further, oral administration of piperine inhibited breast tumor growth in diet-induced obese mice, accompanied by the upregulation of miR-181c-3p and downregulation of PPARalpha expression.	piperine	32-40	peroxisome proliferator activated receptor alpha	Mus musculus	168-177
33682565-4	2021	Next, a series of its derivatives were designed and synthesised based on the underlying interactions of Piperine with CYP2J2.	piperine	104-112	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	118-124
34633734-9	2021	Concentrations of 50 and 200 nM of piperine were 70 to 350 times below the human taste threshold, but TRPV1 desensitization through frequent exposure to sub-taste-threshold concentrations could contribute to an increased tolerance at a later age.	piperine	35-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
34591253-5	2021	In addition, piperine repaired the tight junction damage induced by obesity by downregulating jejunal tumor necrosis factor-alpha and reducing lipopolysaccharide-induced damage on intestinal cell proliferation, thus enhancing intestinal barrier function, which is beneficial in reducing chronic inflammation associated with obesity.	piperine	13-21	tumor necrosis factor	Homo sapiens	102-129
34779955-0	2021	Correction to: Piperine-Loaded Glycyrrhizic Acid- and PLGA-Based Nanoparticles Modified with Transferrin for Antitumor.	piperine	15-23	transferrin	Homo sapiens	93-104
34824301-0	2021	Piperine analogs arrest c-myc gene leading to downregulation of transcription for targeting cancer.	piperine	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	24-29
34824301-3	2021	Piperine shows anticancer properties by stabilizing the G4 motif present upstream of the c-myc gene.	piperine	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	89-94
34824301-10	2021	Biological evaluation assays such as TFP reporter assay, quantitative real-time PCR (qRT- PCR), and western blotting suggest that the Piperine analog-2 (PIP-2) stabilizes the G-quadruplex motif located at the promoter site of c-myc oncogene and downregulates its expression.	piperine	134-142	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	226-231
34824301-11	2021	In conclusion, Piperine analog PIP-2 may be used as anticancer therapeutics as it affects the c-myc oncogene expression via G-quadruplex mediated mechanism.	piperine	15-23	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	94-99
34787055-6	2021	Considering the OMgp as the target protein, two flavonoid libraries (curcumin and piperine) were screened against it to get potential inhibitors.	piperine	82-90	oligodendrocyte myelin glycoprotein	Homo sapiens	16-20
34776989-10	2021	The enhanced drug bioavailability caused by piperine is due to its potent inhibition of drug metabolism, being able to inhibit human P-glycoprotein and CYP3A4, while it interferes with UDP-glucose dehydrogenase and glucuronidation activities in liver.	piperine	44-52	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	152-158
34778375-0	2021	The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-beta/Smads Pathways.	piperine	31-39	microRNA 17	Mus musculus	113-119
34730139-0	2021	Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis.	piperine	0-8	chemokine (C-C motif) ligand 4	Mus musculus	112-116
34730139-0	2021	Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis.	piperine	0-8	nuclear factor, erythroid derived 2, like 2	Mus musculus	149-153
34730139-0	2021	Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis.	piperine	0-8	transforming growth factor, beta 1	Mus musculus	196-205
34730139-0	2021	Piperine inhibits AML-12 hepatocyte EMT and LX-2 HSC activation and alleviates mouse liver fibrosis provoked by CCl4: roles in the activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis.	piperine	0-8	SMAD family member 7	Mus musculus	206-210
34730139-4	2021	We found that PIP inhibited TGF-beta1-provoked AML-12 hepatocyte EMT and LX-2 HSC activation.	piperine	14-17	transforming growth factor, beta 1	Mus musculus	28-37
34730139-5	2021	Mechanistically, in AML-12 and LX-2 cells, PIP evoked Nrf2 nuclear translocation and increased transcriptions of Nrf2-responsive antioxidative genes.	piperine	43-46	NFE2 like bZIP transcription factor 2	Homo sapiens	54-58
34730139-5	2021	Mechanistically, in AML-12 and LX-2 cells, PIP evoked Nrf2 nuclear translocation and increased transcriptions of Nrf2-responsive antioxidative genes.	piperine	43-46	NFE2 like bZIP transcription factor 2	Homo sapiens	113-117
34730139-7	2021	Moreover, PIP increased the expression of Smad7, suppressed phosphorylation and nuclear translocation of Smad2/3, and decreased the transcriptions of Smad2/3-downstream genes.	piperine	10-13	SMAD family member 7	Mus musculus	42-47
34730139-7	2021	Moreover, PIP increased the expression of Smad7, suppressed phosphorylation and nuclear translocation of Smad2/3, and decreased the transcriptions of Smad2/3-downstream genes.	piperine	10-13	SMAD family member 2	Homo sapiens	105-112
34730139-7	2021	Moreover, PIP increased the expression of Smad7, suppressed phosphorylation and nuclear translocation of Smad2/3, and decreased the transcriptions of Smad2/3-downstream genes.	piperine	10-13	SMAD family member 2	Homo sapiens	150-157
34730139-8	2021	Knockdown of Nrf2 abrogated the protective activity of PIP against TGF-beta1.	piperine	55-58	NFE2 like bZIP transcription factor 2	Homo sapiens	13-17
34730139-8	2021	Knockdown of Nrf2 abrogated the protective activity of PIP against TGF-beta1.	piperine	55-58	transforming growth factor, beta 1	Mus musculus	67-76
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	22-25	transforming growth factor, beta 1	Mus musculus	33-42
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	22-25	SMAD family member 7	Mus musculus	43-47
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	22-25	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	22-25	transforming growth factor, beta 1	Mus musculus	174-183
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	22-25	SMAD family member 7	Mus musculus	184-188
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	167-170	transforming growth factor, beta 1	Mus musculus	33-42
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	167-170	SMAD family member 7	Mus musculus	43-47
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	167-170	NFE2 like bZIP transcription factor 2	Homo sapiens	111-115
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	167-170	transforming growth factor, beta 1	Mus musculus	174-183
34730139-9	2021	Modulatory effects of PIP on the TGF-beta1/Smad cascade were also crippled, which suggested that activation of Nrf2 played critical roles in the regulatory effects of PIP on TGF-beta1/Smad signaling.	piperine	167-170	SMAD family member 7	Mus musculus	184-188
34730139-10	2021	Experiments in vivo unveiled that PIP ameliorated mouse liver fibrosis provoked by CCl4.	piperine	34-37	chemokine (C-C motif) ligand 4	Mus musculus	83-87
34730139-14	2021	The activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis are implicated in the hepatoprotective activity of PIP.	piperine	140-143	nuclear factor, erythroid derived 2, like 2	Mus musculus	22-26
34730139-14	2021	The activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis are implicated in the hepatoprotective activity of PIP.	piperine	140-143	transforming growth factor, beta 1	Mus musculus	69-78
34730139-14	2021	The activation of the Nrf2 cascade and subsequent suppression of the TGF-beta1/Smad axis are implicated in the hepatoprotective activity of PIP.	piperine	140-143	SMAD family member 7	Mus musculus	79-83
34338970-7	2021	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-alpha, IL-1beta) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions.	piperine	59-67	tumor necrosis factor	Rattus norvegicus	129-138
34338970-7	2021	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-alpha, IL-1beta) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions.	piperine	59-67	interleukin 1 alpha	Rattus norvegicus	140-148
34338970-7	2021	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-alpha, IL-1beta) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions.	piperine	59-67	nitric oxide synthase 2	Rattus norvegicus	154-158
34338970-7	2021	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-alpha, IL-1beta) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions.	piperine	59-67	interleukin 10	Rattus norvegicus	172-177
34338970-7	2021	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-alpha, IL-1beta) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions.	piperine	59-67	NFE2 like bZIP transcription factor 2	Rattus norvegicus	179-183
34338970-7	2021	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-alpha, IL-1beta) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions.	piperine	59-67	heme oxygenase 1	Rattus norvegicus	185-189
34338970-7	2021	Gene expression analysis in lumbar spinal cord showed that piperine treatment decreased the level of pro-inflammatory cytokines (TNF-alpha, IL-1beta) and iNOS and enhanced IL-10, Nrf2, HO-1, and MBP expressions.	piperine	59-67	myelin basic protein	Rattus norvegicus	195-198
34338970-9	2021	Finally, we found that piperine has anti-apoptotic and neuroprotective effect in EAE through reducing caspase-3 (apoptosis marker) and enhancing BDNF and NeuN expressing cells.	piperine	23-31	caspase 3	Rattus norvegicus	102-111
34338970-9	2021	Finally, we found that piperine has anti-apoptotic and neuroprotective effect in EAE through reducing caspase-3 (apoptosis marker) and enhancing BDNF and NeuN expressing cells.	piperine	23-31	brain-derived neurotrophic factor	Rattus norvegicus	145-149
34338970-9	2021	Finally, we found that piperine has anti-apoptotic and neuroprotective effect in EAE through reducing caspase-3 (apoptosis marker) and enhancing BDNF and NeuN expressing cells.	piperine	23-31	RNA binding fox-1 homolog 3	Rattus norvegicus	154-158
34778375-9	2021	Piperine treatment resulted in a significant downregulation of miRNA-17 expression, leading to the restoration of smad-7 accompanied with marked inhibition of TGF-beta/smads signaling with further suppression of the activated HSCs and collagen deposition in the hepatocytes.	piperine	0-8	SMAD family member 7	Mus musculus	114-120
34778375-9	2021	Piperine treatment resulted in a significant downregulation of miRNA-17 expression, leading to the restoration of smad-7 accompanied with marked inhibition of TGF-beta/smads signaling with further suppression of the activated HSCs and collagen deposition in the hepatocytes.	piperine	0-8	transforming growth factor alpha	Mus musculus	159-167
34778375-10	2021	In conclusion, piperine has the potential to be a promising therapeutic drug for the treatment of liver fibrosis through inhibiting the TGF-beta/smads pathway.	piperine	15-23	transforming growth factor alpha	Mus musculus	136-144
34778375-0	2021	The Hepatoprotective Effect of Piperine Against Thioacetamide-Induced Liver Fibrosis in Mice: The Involvement of miR-17 and TGF-beta/Smads Pathways.	piperine	31-39	transforming growth factor alpha	Mus musculus	124-132
34778375-4	2021	Piperine has recently been studied as a promising anti-fibrotic agent against pancreatic fibrosis through altering the TGF-beta1/Smad pathway.	piperine	0-8	transforming growth factor, beta 1	Mus musculus	119-128
34778375-4	2021	Piperine has recently been studied as a promising anti-fibrotic agent against pancreatic fibrosis through altering the TGF-beta1/Smad pathway.	piperine	0-8	SMAD family member 7	Mus musculus	129-133
34778375-5	2021	Hence, the current study evaluated the beneficial effects of piperine in thioacetamide-induced liver fibrosis in mice through the modulation of miRNA-17 and TGF-beta/smads pathways.	piperine	61-69	transforming growth factor alpha	Mus musculus	157-165
34776989-10	2021	The enhanced drug bioavailability caused by piperine is due to its potent inhibition of drug metabolism, being able to inhibit human P-glycoprotein and CYP3A4, while it interferes with UDP-glucose dehydrogenase and glucuronidation activities in liver.	piperine	44-52	UDP-glucose 6-dehydrogenase	Homo sapiens	185-210
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	piperine	318-326	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
34829745-12	2021	Morphological studies further confirmed that the curcumin and piperine nanogels penetrate the cells via endocytic pathways and induce caspase-3-related apoptosis.	piperine	62-70	caspase 3	Homo sapiens	134-143
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	piperine	318-326	angiotensin converting enzyme 2	Homo sapiens	225-229
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	piperine	53-61	angiotensin converting enzyme 2	Homo sapiens	87-91
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	piperine	53-61	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	101-106
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	piperine	53-61	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	120-125
34481181-10	2021	RESULT: The docking results showed that curcumin and piperine were most potent to bind ACE2, mutated spike, and mutated spike-ACE2 complex, thereby restricting viral entry.	piperine	53-61	angiotensin converting enzyme 2	Homo sapiens	126-130
34481181-13	2021	CONCLUSION: This result provides a significant insight about the phytochemicals" role, namely curcumin and piperine, as the potential therapeutic entities against mutated spike protein of SARS-CoV-2.	piperine	107-115	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	171-176
34284077-8	2021	In addition, PIP pre-treatment suppressed the mitochondrial dysfunction and might have anti-apoptotic potential by preventing Cytochrome c (Cyt c) release from mitochondria to cytoplasm and caspase 3 activation.	piperine	13-16	caspase 3	Rattus norvegicus	190-199
34464498-6	2021	The mechanism of PIP was associated with ROS increase and mitochondrial damage, simultaneously, the expression of key proteins of apoptosis was affected, including Bcl-2, Bax, Cyt-c, Caspase-9 and Caspase-3.	piperine	17-20	BCL2 apoptosis regulator	Homo sapiens	164-169
34464498-6	2021	The mechanism of PIP was associated with ROS increase and mitochondrial damage, simultaneously, the expression of key proteins of apoptosis was affected, including Bcl-2, Bax, Cyt-c, Caspase-9 and Caspase-3.	piperine	17-20	BCL2 associated X, apoptosis regulator	Homo sapiens	171-174
34464498-6	2021	The mechanism of PIP was associated with ROS increase and mitochondrial damage, simultaneously, the expression of key proteins of apoptosis was affected, including Bcl-2, Bax, Cyt-c, Caspase-9 and Caspase-3.	piperine	17-20	caspase 9	Homo sapiens	183-192
34464498-6	2021	The mechanism of PIP was associated with ROS increase and mitochondrial damage, simultaneously, the expression of key proteins of apoptosis was affected, including Bcl-2, Bax, Cyt-c, Caspase-9 and Caspase-3.	piperine	17-20	caspase 3	Homo sapiens	197-206
34284077-10	2021	Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) results also showed that PIP reduced the expression of pro-inflammatory protein, interleukin-1 beta (IL-1beta) and enhanced cell survival by restoring the activity of brain derived neurotrophic factor (BDNF) and its transcription protein, cAMP response element binding protein (CREB).	piperine	96-99	interleukin 1 alpha	Rattus norvegicus	172-180
34284077-10	2021	Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) results also showed that PIP reduced the expression of pro-inflammatory protein, interleukin-1 beta (IL-1beta) and enhanced cell survival by restoring the activity of brain derived neurotrophic factor (BDNF) and its transcription protein, cAMP response element binding protein (CREB).	piperine	96-99	brain-derived neurotrophic factor	Rattus norvegicus	238-271
34284077-10	2021	Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) results also showed that PIP reduced the expression of pro-inflammatory protein, interleukin-1 beta (IL-1beta) and enhanced cell survival by restoring the activity of brain derived neurotrophic factor (BDNF) and its transcription protein, cAMP response element binding protein (CREB).	piperine	96-99	interleukin 1 beta	Rattus norvegicus	152-170
34284077-10	2021	Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) results also showed that PIP reduced the expression of pro-inflammatory protein, interleukin-1 beta (IL-1beta) and enhanced cell survival by restoring the activity of brain derived neurotrophic factor (BDNF) and its transcription protein, cAMP response element binding protein (CREB).	piperine	96-99	brain-derived neurotrophic factor	Rattus norvegicus	273-277
34284077-10	2021	Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) results also showed that PIP reduced the expression of pro-inflammatory protein, interleukin-1 beta (IL-1beta) and enhanced cell survival by restoring the activity of brain derived neurotrophic factor (BDNF) and its transcription protein, cAMP response element binding protein (CREB).	piperine	96-99	cAMP responsive element binding protein 1	Rattus norvegicus	310-347
34284077-10	2021	Quantitative Reverse transcription-polymerase chain reaction (qRT-PCR) results also showed that PIP reduced the expression of pro-inflammatory protein, interleukin-1 beta (IL-1beta) and enhanced cell survival by restoring the activity of brain derived neurotrophic factor (BDNF) and its transcription protein, cAMP response element binding protein (CREB).	piperine	96-99	cAMP responsive element binding protein 1	Rattus norvegicus	349-353
34092198-0	2022	Piperine promotes autophagy flux by P2RX4 activation in SNCA/alpha-synuclein-induced Parkinson disease model.	piperine	0-8	purinergic receptor P2X 4	Homo sapiens	36-41
34590204-0	2021	Piperine-Loaded Glycyrrhizic Acid- and PLGA-Based Nanoparticles Modified with Transferrin for Antitumor : Piperine-Loaded Glycyrrhizic Acid- and PLGA-Based Nanoparticles.	piperine	0-8	transferrin	Homo sapiens	78-89
34590204-1	2021	The purpose of this study was to enhance the antitumor effect of piperine by constructing the nanoparticles modified with transferrin (Tf-PIP-NPs) and evaluating their efficacy in vitro and in vivo.	piperine	65-73	transferrin	Homo sapiens	122-133
34364309-3	2021	Moreover, a visual high-throughput screening method was established using DAND, piperine was identified as a novel inhibitor of FAAH.	piperine	80-88	fatty acid amide hydrolase	Mus musculus	128-132
34364309-4	2021	Based on the interaction of piperine with FAAH, a more potent FAAH inhibitor (11f) was designed and synthesized which possessed an IC50 value of 0.65 muM.	piperine	28-36	fatty acid amide hydrolase	Mus musculus	42-46
34364309-4	2021	Based on the interaction of piperine with FAAH, a more potent FAAH inhibitor (11f) was designed and synthesized which possessed an IC50 value of 0.65 muM.	piperine	28-36	fatty acid amide hydrolase	Mus musculus	62-66
34092198-0	2022	Piperine promotes autophagy flux by P2RX4 activation in SNCA/alpha-synuclein-induced Parkinson disease model.	piperine	0-8	synuclein alpha	Homo sapiens	56-60
34092198-0	2022	Piperine promotes autophagy flux by P2RX4 activation in SNCA/alpha-synuclein-induced Parkinson disease model.	piperine	0-8	synuclein alpha	Homo sapiens	61-76
34092198-6	2022	We found that PIP oral administration (25, 50 and 100 mg/kg) for 6 weeks attenuated olfactory deficits and delayed motor deficits in Thy 1-SNCA transgenic mice overexpressing human SNCA.	piperine	14-17	thymus cell antigen 1, theta	Mus musculus	133-138
34092198-6	2022	We found that PIP oral administration (25, 50 and 100 mg/kg) for 6 weeks attenuated olfactory deficits and delayed motor deficits in Thy 1-SNCA transgenic mice overexpressing human SNCA.	piperine	14-17	synuclein, alpha	Mus musculus	139-143
34092198-6	2022	We found that PIP oral administration (25, 50 and 100 mg/kg) for 6 weeks attenuated olfactory deficits and delayed motor deficits in Thy 1-SNCA transgenic mice overexpressing human SNCA.	piperine	14-17	synuclein alpha	Homo sapiens	181-185
34092198-8	2022	In addition, PIP improved cell viability and promoted degradation of human SNCA in SK-N-SH cells.	piperine	13-16	synuclein alpha	Homo sapiens	75-79
34092198-10	2022	Furthermore, tandem mass tag proteomics analyses showed that P2RX4 plays an important role in PIP treatment-induced activation of autophagy flux.	piperine	94-97	purinergic receptor P2X 4	Homo sapiens	61-66
34092292-12	2021	MiR-520a can specifically and directly target P65, and piperine can promote the expression of miR-520a, then inhibit the expression of p65, down-regulate the pro-inflammatory factors IL-1beta and TNF-alpha, and up-regulate the effects of anti-inflammatory factors IL-10 and TGF-beta1, so as to treat sciatica.	piperine	55-63	interleukin 1 alpha	Rattus norvegicus	183-191
34092292-12	2021	MiR-520a can specifically and directly target P65, and piperine can promote the expression of miR-520a, then inhibit the expression of p65, down-regulate the pro-inflammatory factors IL-1beta and TNF-alpha, and up-regulate the effects of anti-inflammatory factors IL-10 and TGF-beta1, so as to treat sciatica.	piperine	55-63	tumor necrosis factor	Rattus norvegicus	196-205
34092292-0	2021	Piperine treating sciatica through regulating inflammation and MiR-520a/P65 pathway.	piperine	0-8	synaptotagmin 1	Rattus norvegicus	72-75
34092292-12	2021	MiR-520a can specifically and directly target P65, and piperine can promote the expression of miR-520a, then inhibit the expression of p65, down-regulate the pro-inflammatory factors IL-1beta and TNF-alpha, and up-regulate the effects of anti-inflammatory factors IL-10 and TGF-beta1, so as to treat sciatica.	piperine	55-63	interleukin 10	Rattus norvegicus	264-269
34092292-3	2021	The purpose of this study is to verify the regulatory relationship between miR-520a and p65 and to explore how miR-520a/P65 affects the level of cytokines under the action of piperine, so as to play a therapeutic role in sciatica.	piperine	175-183	synaptotagmin 1	Rattus norvegicus	88-91
34092292-3	2021	The purpose of this study is to verify the regulatory relationship between miR-520a and p65 and to explore how miR-520a/P65 affects the level of cytokines under the action of piperine, so as to play a therapeutic role in sciatica.	piperine	175-183	synaptotagmin 1	Rattus norvegicus	120-123
34092292-12	2021	MiR-520a can specifically and directly target P65, and piperine can promote the expression of miR-520a, then inhibit the expression of p65, down-regulate the pro-inflammatory factors IL-1beta and TNF-alpha, and up-regulate the effects of anti-inflammatory factors IL-10 and TGF-beta1, so as to treat sciatica.	piperine	55-63	transforming growth factor, beta 1	Rattus norvegicus	274-283
34092292-9	2021	Immunohistochemical analysis showed that the expression of p65 decreased after administration of piperine.	piperine	97-105	synaptotagmin 1	Rattus norvegicus	59-62
34183962-10	2021	Piperine (20 muM) and cisplatin (5 muM) for 24 h induce apoptosis strongly through reduction of Bcl-2 and increase of caspase 3, p53, caspase 9, and Bax.	piperine	0-8	BCL2 apoptosis regulator	Homo sapiens	96-101
34092292-12	2021	MiR-520a can specifically and directly target P65, and piperine can promote the expression of miR-520a, then inhibit the expression of p65, down-regulate the pro-inflammatory factors IL-1beta and TNF-alpha, and up-regulate the effects of anti-inflammatory factors IL-10 and TGF-beta1, so as to treat sciatica.	piperine	55-63	synaptotagmin 1	Rattus norvegicus	135-138
34183962-10	2021	Piperine (20 muM) and cisplatin (5 muM) for 24 h induce apoptosis strongly through reduction of Bcl-2 and increase of caspase 3, p53, caspase 9, and Bax.	piperine	0-8	caspase 3	Homo sapiens	118-127
34183962-10	2021	Piperine (20 muM) and cisplatin (5 muM) for 24 h induce apoptosis strongly through reduction of Bcl-2 and increase of caspase 3, p53, caspase 9, and Bax.	piperine	0-8	tumor protein p53	Homo sapiens	129-132
34183962-10	2021	Piperine (20 muM) and cisplatin (5 muM) for 24 h induce apoptosis strongly through reduction of Bcl-2 and increase of caspase 3, p53, caspase 9, and Bax.	piperine	0-8	caspase 9	Homo sapiens	134-143
34183962-10	2021	Piperine (20 muM) and cisplatin (5 muM) for 24 h induce apoptosis strongly through reduction of Bcl-2 and increase of caspase 3, p53, caspase 9, and Bax.	piperine	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	149-152
34183962-11	2021	Conclusion: Piperine in combination with cisplatin could trigger p53-mediated apoptosis more effective than cisplatin alone in MCF-7 breast cancer cells, reducing the toxic dose of cisplatin used in cancer chemotherapy.	piperine	12-20	tumor protein p53	Homo sapiens	65-68
35628429-0	2022	Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.	piperine	0-8	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	68-73
35597410-0	2022	Piperine ameliorates ischemic stroke-induced brain injury in rats by regulating the PI3K/AKT/mTOR pathway.	piperine	0-8	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
35597410-0	2022	Piperine ameliorates ischemic stroke-induced brain injury in rats by regulating the PI3K/AKT/mTOR pathway.	piperine	0-8	mechanistic target of rapamycin kinase	Rattus norvegicus	93-97
35597410-17	2022	The expression levels of p-mTOR, p-AKT, and p-PI3K in the hippocampus and cortex of the 30 mg/kg PIP and Nimo intervention groups decreased, whereas the expression level of PI3K increased (all p < 0.05).	piperine	97-100	mechanistic target of rapamycin kinase	Rattus norvegicus	27-31
35597410-17	2022	The expression levels of p-mTOR, p-AKT, and p-PI3K in the hippocampus and cortex of the 30 mg/kg PIP and Nimo intervention groups decreased, whereas the expression level of PI3K increased (all p < 0.05).	piperine	97-100	AKT serine/threonine kinase 1	Rattus norvegicus	35-38
35597410-18	2022	In addition, the expression level of autophagy-related proteins, namely, Beclin1 and LC3-II, in the 30 mg/kg PIP and Nimo intervention groups decreased (all p < 0.05).	piperine	109-112	beclin 1	Rattus norvegicus	73-80
35597410-18	2022	In addition, the expression level of autophagy-related proteins, namely, Beclin1 and LC3-II, in the 30 mg/kg PIP and Nimo intervention groups decreased (all p < 0.05).	piperine	109-112	annexin A3	Rattus norvegicus	85-88
35597410-20	2022	Western blot results showed that compared with the OGD group, the expression level of p-mTOR, p-AKT, and p-PI3K in the 30 and 40 mug/mL PIP intervention groups decreased, and the expression level of PI3K increased (all p < 0.05).	piperine	136-139	mechanistic target of rapamycin kinase	Rattus norvegicus	88-92
35597410-20	2022	Western blot results showed that compared with the OGD group, the expression level of p-mTOR, p-AKT, and p-PI3K in the 30 and 40 mug/mL PIP intervention groups decreased, and the expression level of PI3K increased (all p < 0.05).	piperine	136-139	AKT serine/threonine kinase 1	Rattus norvegicus	96-99
35597410-21	2022	Moreover, the expression level of autophagy-related proteins, namely, Beclin1 and LC3-II, in the 30 and 40 mug/mL PIP intervention groups decreased (all p < 0.05).	piperine	114-117	beclin 1	Rattus norvegicus	70-77
35597410-21	2022	Moreover, the expression level of autophagy-related proteins, namely, Beclin1 and LC3-II, in the 30 and 40 mug/mL PIP intervention groups decreased (all p < 0.05).	piperine	114-117	annexin A3	Rattus norvegicus	82-85
35597410-23	2022	PIP can inhibit the PI3K/AKT/mTOR pathway and autophagy.	piperine	0-3	AKT serine/threonine kinase 1	Rattus norvegicus	25-28
35597410-23	2022	PIP can inhibit the PI3K/AKT/mTOR pathway and autophagy.	piperine	0-3	mechanistic target of rapamycin kinase	Rattus norvegicus	29-33
35628429-0	2022	Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells.	piperine	0-8	clock circadian regulator	Homo sapiens	78-83
35628429-6	2022	The effect of PIP on redox status, mitochondrial functions, and circadian rhythms of core clock genes were evaluated.	piperine	14-17	clock circadian regulator	Homo sapiens	90-95
35628429-8	2022	A mechanism study showed that PIP could activate the SREBP-1c/PPARgamma and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells.	piperine	30-33	sterol regulatory element binding transcription factor 1	Homo sapiens	53-61
35628429-8	2022	A mechanism study showed that PIP could activate the SREBP-1c/PPARgamma and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells.	piperine	30-33	peroxisome proliferator activated receptor gamma	Homo sapiens	62-71
35628429-8	2022	A mechanism study showed that PIP could activate the SREBP-1c/PPARgamma and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells.	piperine	30-33	AKT serine/threonine kinase 1	Homo sapiens	81-84
35628429-8	2022	A mechanism study showed that PIP could activate the SREBP-1c/PPARgamma and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells.	piperine	30-33	mechanistic target of rapamycin kinase	Homo sapiens	85-89
35628429-8	2022	A mechanism study showed that PIP could activate the SREBP-1c/PPARgamma and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells.	piperine	30-33	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	114-119
35628429-8	2022	A mechanism study showed that PIP could activate the SREBP-1c/PPARgamma and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells.	piperine	30-33	clock circadian regulator	Homo sapiens	120-125
35628429-9	2022	These results indicated that Bmal1 and Clock played important roles in the regulating effect of PIP on hepatic lipid homeostasis.	piperine	96-99	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	29-34
35628429-9	2022	These results indicated that Bmal1 and Clock played important roles in the regulating effect of PIP on hepatic lipid homeostasis.	piperine	96-99	clock circadian regulator	Homo sapiens	39-44
35367582-3	2022	In this study, positively charged PIP-loaded nanostructured lipid carriers (PIP-NLCs) were prepared via melt-emulsification and ultra-sonication method followed by pectin coating to get novel pectin-coated NLCs (PIP-P-NLCs) targeting hepatocellular carcinoma.	piperine	34-37	inositol polyphosphate-5-phosphatase J	Homo sapiens	212-217
35367582-10	2022	Furthermore, PIP-P-NLCs improved in vivo anticancer effect of PIP as proved by histological examination of liver tissues, suppression of liver enzymes and oxidative stress environment in the liver, and alteration of cell cycle regulators.	piperine	62-65	inositol polyphosphate-5-phosphatase J	Homo sapiens	13-18
35367582-11	2022	To conclude, PIP-P-NLCs can act as a promising approach for targeted delivery of PIP to hepatocellular carcinoma.	piperine	81-84	inositol polyphosphate-5-phosphatase J	Homo sapiens	13-18
35565989-7	2022	In addition, piperine decreased the expression of the NGF precursor proNGF and NGF-degrading protease matrix metalloproteinase 9, whereas it increased the expression of proNGF processing enzyme matrix metalloproteinase 7, NGF, and NGF-activated receptor TrkA in the hippocampus of KA-treated rats.	piperine	13-21	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	254-258
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	piperine	322-330	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	piperine	322-330	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	159-164
35565989-8	2022	Furthermore, KA decreased phosphorylation of the protein kinase B (Akt) and glycogen synthase kinase 3beta (GSK3beta) in the hippocampus, and piperine reversed these changes.	piperine	142-150	AKT serine/threonine kinase 1	Rattus norvegicus	67-70
35565989-8	2022	Furthermore, KA decreased phosphorylation of the protein kinase B (Akt) and glycogen synthase kinase 3beta (GSK3beta) in the hippocampus, and piperine reversed these changes.	piperine	142-150	glycogen synthase kinase 3 beta	Rattus norvegicus	76-106
35565989-8	2022	Furthermore, KA decreased phosphorylation of the protein kinase B (Akt) and glycogen synthase kinase 3beta (GSK3beta) in the hippocampus, and piperine reversed these changes.	piperine	142-150	glycogen synthase kinase 3 alpha	Rattus norvegicus	108-116
35565989-9	2022	Our data suggest that piperine protects hippocampal neurons against KA-induced excitotoxicity by upregulating the NGF/TrkA/Akt/GSK3beta signalling pathways.	piperine	22-30	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	118-122
35565989-9	2022	Our data suggest that piperine protects hippocampal neurons against KA-induced excitotoxicity by upregulating the NGF/TrkA/Akt/GSK3beta signalling pathways.	piperine	22-30	AKT serine/threonine kinase 1	Rattus norvegicus	123-126
35565989-9	2022	Our data suggest that piperine protects hippocampal neurons against KA-induced excitotoxicity by upregulating the NGF/TrkA/Akt/GSK3beta signalling pathways.	piperine	22-30	glycogen synthase kinase 3 alpha	Rattus norvegicus	127-135
35400961-0	2022	Immunosuppression by piperine as a regulator of the NLRP3 inflammasome through MAPK/NF-kappaB in monosodium urate-induced rat gouty arthritis.	piperine	21-29	NLR family, pyrin domain containing 3	Rattus norvegicus	52-57
35382657-2	2022	To reduce the Abeta fibril toxicity multi-functional polyamidoamine (PAMAM) dendrimer was conjugated with tocopheryl polyethylene glycol succinate-1000 (TPGS) which acts as a carrier matrix for the delivery of neuroprotective molecule piperine (PIP).	piperine	235-243	amyloid beta precursor protein	Homo sapiens	14-19
35382657-2	2022	To reduce the Abeta fibril toxicity multi-functional polyamidoamine (PAMAM) dendrimer was conjugated with tocopheryl polyethylene glycol succinate-1000 (TPGS) which acts as a carrier matrix for the delivery of neuroprotective molecule piperine (PIP).	piperine	245-248	amyloid beta precursor protein	Homo sapiens	14-19
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	piperine	26-34	interleukin 2	Homo sapiens	188-192
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	piperine	26-34	tumor necrosis factor	Homo sapiens	194-203
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	piperine	26-34	cobalamin binding intrinsic factor	Homo sapiens	205-208
35453772-9	2022	CONCLUSIONS: curcumin and piperine supplementation had no effect on physical performance, immune cell counts, or muscle damage; however, the supplementation could modulate the kinetics of IL-2, TNF-alpha, INF, IL-6, and IL-10 1 h after the end of exercise.	piperine	26-34	interleukin 6	Homo sapiens	210-214
35620326-0	2022	Regulatory Effects of Apatinib in Combination with Piperine on MDM-2 Gene Expression, Glutathione Peroxidase Activity and Nitric Oxide level as Mechanisms of Cytotoxicity in Colorectal Cancer Cells.	piperine	51-59	MDM2 proto-oncogene	Homo sapiens	63-68
35620326-8	2022	When HCT-116 cells were treated with different concentrations of apatinibin combination with piperine, the synergistic effects were observed (combination index < 1).In HCT-116 cells treated with apatinib and piperine at the concentrations of 0.5xIC50 and0.2xIC50, the MDM-2 gene expression was downregulated and NO levels increased comparedto the untreated control cells and related single treatments.	piperine	93-101	MDM2 proto-oncogene	Homo sapiens	268-273
35156972-6	2022	The lower limit of quantification (LLOQ) of quercetin and piperine was obtained as 0.1 ng mL-1 in rat plasma, along with negligible matrix effect and acceptable stability.	piperine	58-66	L1 cell adhesion molecule	Mus musculus	90-94
34997607-4	2022	The effect of piperine, a P-glycoprotein (P-gp) inhibitor on daclatasvir absorption from jejunum and ileum was tested.	piperine	14-22	ATP binding cassette subfamily B member 1	Homo sapiens	26-40
35534255-1	2022	This study aims to establish a method for determination of paeonol(Pae), eugenol(Eug), and piperine(Pip) content in receptor liquid and research on the permeability and pharmacokinetics of Huoxue Zhitong gel patch and microemulsion gel.	piperine	91-99	prolactin induced protein	Homo sapiens	100-103
35168518-6	2022	PIP is known to inhibit drug transporter P-glycoprotein.	piperine	0-3	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	41-55
35400961-4	2022	In this study, we examined the effect of PIP in immunosuppression of gout inflammation through the regulation of the NLRP3 inflammasome.	piperine	41-44	NLR family, pyrin domain containing 3	Rattus norvegicus	117-122
35400961-5	2022	Materials and Methods: An in silico study was done by pharmacodynamic modeling of PIP in suppressing MSU-induced inflammation through disruption of the NLRP3 inflammasome.	piperine	82-85	NLR family, pyrin domain containing 3	Rattus norvegicus	152-157
35400961-7	2022	Results: In silico studies of molecular docking demonstrated the activity of PIP as a competitive inhibitor of the mitogen-activated protein kinases/nuclear factor-kappa B axis, upstream of the NLRP3 inflammasome.	piperine	77-80	NLR family, pyrin domain containing 3	Rattus norvegicus	194-199
35400961-8	2022	Analysis of gout models with curative and preventive protocols revealed the immunosuppression activity of PIP by reducing inflammatory symptoms, inhibiting tophus formation resulting from NETosis, reducing cartilage erosion, inhibiting leukocyte exudation, suppressing lipid peroxidation index, and inhibiting the production of C-reactive protein.	piperine	106-109	C-reactive protein	Rattus norvegicus	328-346
34996326-6	2022	The other important clinical applications of piperine are due to its bio enhancing effect on drugs, by modulating, absorption in the gastrointestinal tract, altering activities of transporters like p-glycoprotein substrates, and modulating drug metabolism by altering the expression of cytochrome P450 or UDP-glucuronosyltransferase enzymes.	piperine	45-53	ATP binding cassette subfamily B member 1	Homo sapiens	198-212
34931204-3	2022	When THP-1 monocytes were co-treated with the identified compounds (e.g., piperine) and CUR, cell viability significantly decreased, suggesting that the physiological activity of CUR was enhanced.	piperine	74-82	GLI family zinc finger 2	Homo sapiens	5-10
34996326-6	2022	The other important clinical applications of piperine are due to its bio enhancing effect on drugs, by modulating, absorption in the gastrointestinal tract, altering activities of transporters like p-glycoprotein substrates, and modulating drug metabolism by altering the expression of cytochrome P450 or UDP-glucuronosyltransferase enzymes.	piperine	45-53	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	286-301
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	AKT serine/threonine kinase 1	Homo sapiens	60-63
34881772-5	2022	Moreover, piperine and FA activated TAS2R14 signaling as evidenced by the increased mRNA and protein levels of TAS2R14, and the protein expression of its downstream key molecules including phospholipase C beta2 (PLCbeta2) and a transient receptor potential channel melastatin 5 (TRPM5).	piperine	10-18	phospholipase C beta 2	Homo sapiens	189-210
34881772-5	2022	Moreover, piperine and FA activated TAS2R14 signaling as evidenced by the increased mRNA and protein levels of TAS2R14, and the protein expression of its downstream key molecules including phospholipase C beta2 (PLCbeta2) and a transient receptor potential channel melastatin 5 (TRPM5).	piperine	10-18	interleukin 31 receptor A	Homo sapiens	212-220
34881772-5	2022	Moreover, piperine and FA activated TAS2R14 signaling as evidenced by the increased mRNA and protein levels of TAS2R14, and the protein expression of its downstream key molecules including phospholipase C beta2 (PLCbeta2) and a transient receptor potential channel melastatin 5 (TRPM5).	piperine	10-18	transient receptor potential cation channel subfamily M member 5	Homo sapiens	228-277
34881772-5	2022	Moreover, piperine and FA activated TAS2R14 signaling as evidenced by the increased mRNA and protein levels of TAS2R14, and the protein expression of its downstream key molecules including phospholipase C beta2 (PLCbeta2) and a transient receptor potential channel melastatin 5 (TRPM5).	piperine	10-18	transient receptor potential cation channel subfamily M member 5	Homo sapiens	279-284
34881772-6	2022	On the other hand, a G protein betagamma subunit inhibitor Gallein or a PLC inhibitor U73122 alleviated piperine-stimulated GLP-1 secretion in Caco-2 cells.	piperine	104-112	glucagon	Homo sapiens	124-129
34881772-7	2022	In the meantime, a flavanone hesperetin significantly attenuated piperine and FA induced the intracellular calcium mobilization and GLP-1 secretion.	piperine	65-73	glucagon	Homo sapiens	132-137
34881772-8	2022	Furthermore, TAS2R14 knockdown reversed the piperine-triggered up-regulation of PLCbeta2 and TRPM5 as well as increased the GLP-1 secretion in Caco-2 cells by TAS2R14 shRNA transfection.	piperine	44-52	interleukin 31 receptor A	Homo sapiens	80-88
34881772-8	2022	Furthermore, TAS2R14 knockdown reversed the piperine-triggered up-regulation of PLCbeta2 and TRPM5 as well as increased the GLP-1 secretion in Caco-2 cells by TAS2R14 shRNA transfection.	piperine	44-52	transient receptor potential cation channel subfamily M member 5	Homo sapiens	93-98
34881772-8	2022	Furthermore, TAS2R14 knockdown reversed the piperine-triggered up-regulation of PLCbeta2 and TRPM5 as well as increased the GLP-1 secretion in Caco-2 cells by TAS2R14 shRNA transfection.	piperine	44-52	glucagon	Homo sapiens	124-129
34881772-8	2022	Furthermore, TAS2R14 knockdown reversed the piperine-triggered up-regulation of PLCbeta2 and TRPM5 as well as increased the GLP-1 secretion in Caco-2 cells by TAS2R14 shRNA transfection.	piperine	44-52	taste 2 receptor member 14	Homo sapiens	159-166
34881772-9	2022	In summary, our findings demonstrated that piperine promoted the GLP-1 secretion from enteroendocrine cells through the activation of TAS2R14 signaling.	piperine	43-51	glucagon	Homo sapiens	65-70
34881772-9	2022	In summary, our findings demonstrated that piperine promoted the GLP-1 secretion from enteroendocrine cells through the activation of TAS2R14 signaling.	piperine	43-51	taste 2 receptor member 14	Homo sapiens	134-141
34881772-10	2022	Moreover, TAS2R14 was likely a target of piperine in the alleviation of metabolic diseases.	piperine	41-49	taste 2 receptor member 14	Homo sapiens	10-17
34881772-0	2022	Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2.	piperine	0-8	taste 2 receptor member 14	Homo sapiens	15-22
34881772-0	2022	Piperine, as a TAS2R14 agonist, stimulates the secretion of glucagon-like peptide-1 in the human enteroendocrine cell line Caco-2.	piperine	0-8	glucagon	Homo sapiens	60-83
34881772-4	2022	Piperine and flufenamic acid (FA, a known TAS2R14 agonist) markedly increased intracellular calcium mobilization and significantly enhanced the GLP-1 secretion, accompanied by elevated levels of proglucagon mRNA in Caco-2 cells compared with the control.	piperine	0-8	glucagon	Homo sapiens	144-149
34881772-5	2022	Moreover, piperine and FA activated TAS2R14 signaling as evidenced by the increased mRNA and protein levels of TAS2R14, and the protein expression of its downstream key molecules including phospholipase C beta2 (PLCbeta2) and a transient receptor potential channel melastatin 5 (TRPM5).	piperine	10-18	taste 2 receptor member 14	Homo sapiens	36-43
34881772-5	2022	Moreover, piperine and FA activated TAS2R14 signaling as evidenced by the increased mRNA and protein levels of TAS2R14, and the protein expression of its downstream key molecules including phospholipase C beta2 (PLCbeta2) and a transient receptor potential channel melastatin 5 (TRPM5).	piperine	10-18	taste 2 receptor member 14	Homo sapiens	111-118
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	mechanistic target of rapamycin kinase	Homo sapiens	64-68
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	matrix metallopeptidase 9	Homo sapiens	69-74
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	NLR family pyrin domain containing 3	Homo sapiens	118-154
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	protein kinase C alpha	Homo sapiens	195-210
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	222-226
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	matrix metallopeptidase 9	Homo sapiens	227-232
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	catenin beta 1	Homo sapiens	238-250
35127957-6	2022	Piperine also regulates multiple signaling pathways such as Akt/mTOR/MMP-9, 5"-AMP-activated protein kinase-activated NLR family pyrin domain containing-3 inflammasome, voltage-gated K+ current, PKCalpha/ERK1/2, NF-kappaB/AP-1/MMP-9, Wnt/beta-catenin, JNK/P38 MAPK, and gut microbiota.	piperine	0-8	mitogen-activated protein kinase 8	Homo sapiens	252-255