PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25352195-6	2014	Compared with the CS group, the FTS group had significantly shorter duration to first flatus, time to regular diet, postoperative hospital days and hospital expense, less complications, lower white blood count (WBC) and serum of C-reactive protein (CRP) on postoperative day 5 and 7.	fts	32-35	C-reactive protein	Homo sapiens	229-247
32073997-0	2020	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	fts	4-7	transcription factor AP-4	Homo sapiens	47-51
32073997-0	2020	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	fts	4-7	transcription factor AP-4	Homo sapiens	91-95
32073997-0	2020	The FTS-Hook-FHIP (FHF) complex interacts with AP-4 to mediate perinuclear distribution of AP-4 and its cargo ATG9A.	fts	4-7	autophagy related 9A	Homo sapiens	110-115
32073997-5	2020	This approach resulted in the identification of the FTS-Hook-FHIP (FHF) complex as a novel AP-4 accessory factor.	fts	52-55	transcription factor AP-4	Homo sapiens	91-95
29578035-5	2018	Treating hippocampal slices with FTS (5 muM) for 2 h enhanced selectively NMDAr-dependent LTP without changing the synaptic properties.	fts	33-36	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	74-79
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	mitogen-activated protein kinase 1	Mus musculus	47-51
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	cAMP responsive element binding protein 1	Mus musculus	56-60
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	mitogen-activated protein kinase 1	Mus musculus	195-199
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	cAMP responsive element binding protein 1	Mus musculus	204-208
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	neuropeptide Y receptor Y6	Mus musculus	293-296
29578035-8	2018	In FTS-treated slices, basal levels of CaMKII, ERK2 and CREB phosphorylation did not differ significantly from those of controls; however, high-frequency stimulation-induced increases in CaMKII, ERK2 and CREB phosphorylation were more significant than in the controls, which were sensitive to PP2 and NMDAr antagonist MK801.	fts	3-6	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	301-306
29578035-9	2018	Furthermore, the phosphorylation of AMPA receptor GluR1 during LTP was higher in FTS-treated slices compared with the control, which depended on Src and ERK1/2 signaling.	fts	81-84	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	50-55
29578035-9	2018	Furthermore, the phosphorylation of AMPA receptor GluR1 during LTP was higher in FTS-treated slices compared with the control, which depended on Src and ERK1/2 signaling.	fts	81-84	Rous sarcoma oncogene	Mus musculus	145-148
29578035-9	2018	Furthermore, the phosphorylation of AMPA receptor GluR1 during LTP was higher in FTS-treated slices compared with the control, which depended on Src and ERK1/2 signaling.	fts	81-84	mitogen-activated protein kinase 3	Mus musculus	153-159
27517680-5	2016	RESULTS: The inflammatory mediators (CRP, IL-6, TNF-alpha) were lower in the FTS group than in the traditional group (P < 0.05) on postoperative day (POD) 1, POD 4, and POD 6, and the immunological indicators (IgG, IgA, C3, C4) of the FTS group were superior to those of the traditional group (P < 0.05) on POD 4 and POD 6.	fts	77-80	interleukin 6	Homo sapiens	42-46
27517680-5	2016	RESULTS: The inflammatory mediators (CRP, IL-6, TNF-alpha) were lower in the FTS group than in the traditional group (P < 0.05) on postoperative day (POD) 1, POD 4, and POD 6, and the immunological indicators (IgG, IgA, C3, C4) of the FTS group were superior to those of the traditional group (P < 0.05) on POD 4 and POD 6.	fts	77-80	tumor necrosis factor	Homo sapiens	48-57
30929573-13	2019	Conclusions: It is proposed that IF analysis of 53BP1 expression could be a novel diagnostic method to estimate the malignant potential of FTs.	fts	139-142	tumor protein p53 binding protein 1	Homo sapiens	48-53
30929573-15	2019	IF analysis of 53BP1 expression will not only be an auxiliary histologic technique to diagnose FTs accurately, but also a novel technique for preoperative diagnosis using fine-needle aspiration cytology.	fts	95-98	tumor protein p53 binding protein 1	Homo sapiens	15-20
25352195-6	2014	Compared with the CS group, the FTS group had significantly shorter duration to first flatus, time to regular diet, postoperative hospital days and hospital expense, less complications, lower white blood count (WBC) and serum of C-reactive protein (CRP) on postoperative day 5 and 7.	fts	32-35	C-reactive protein	Homo sapiens	249-252
21882255-9	2012	Moreover, FTS treatment shifted cell proliferation from transformed hepatocytes to apparently normal, GSTp negative hepatocytes.	fts	10-13	glutathione S-transferase pi 1	Rattus norvegicus	102-106
15255937-8	2004	Neuroprotection is inhibited by SN-50, a specific inhibitor of nuclear factor-kappa B (NF-kappaB) and by the Ras inhibitor S-trans, trans-farnesylthiosalicylic acid (FTS) implicating NF-kappaB and Ras in the neuroprotective signaling pathway activated by GW5074.	fts	166-169	nuclear factor kappa B subunit 1	Homo sapiens	183-192
22376253-4	2012	NRG-1 antibody added in conditional medium of BMSCs, si-ErbB3, and four Ras/Raf/MEK/ERK pathway inhibitors (FTS, Sulindac, U0126, and PD98059) were using to investigate the effect of AChRd levels.	fts	108-111	neuregulin 1	Mus musculus	0-5
23227266-7	2012	We show here that the beta-catenin inhibitors PKF115-584 and pyrvinium pamoate block beta-catenin-dependent transcriptional activity and synergize with the KRAS inhibitor S-trans, trans-farnesylthiosalicylic acid (FTS, salirasib) in colon cancer cells driven by Wnt and KRAS oncogenic signals, but not in cells carrying BRAF mutations.	fts	214-217	catenin beta 1	Homo sapiens	22-34
23227266-7	2012	We show here that the beta-catenin inhibitors PKF115-584 and pyrvinium pamoate block beta-catenin-dependent transcriptional activity and synergize with the KRAS inhibitor S-trans, trans-farnesylthiosalicylic acid (FTS, salirasib) in colon cancer cells driven by Wnt and KRAS oncogenic signals, but not in cells carrying BRAF mutations.	fts	214-217	catenin beta 1	Homo sapiens	85-97
23227266-7	2012	We show here that the beta-catenin inhibitors PKF115-584 and pyrvinium pamoate block beta-catenin-dependent transcriptional activity and synergize with the KRAS inhibitor S-trans, trans-farnesylthiosalicylic acid (FTS, salirasib) in colon cancer cells driven by Wnt and KRAS oncogenic signals, but not in cells carrying BRAF mutations.	fts	214-217	KRAS proto-oncogene, GTPase	Homo sapiens	156-160
17178866-4	2006	FTS, by down-regulating Ras activity in glioblastoma multiforme cells, inhibited phosphatidylinositol 3-kinase signaling, resulting in decreased activity of Rac-1.	fts	0-3	Rac family small GTPase 1	Homo sapiens	157-162
20682656-7	2010	FTS disrupted interactions between Gal-3 and K.Ras, strongly reduced K-Ras.GTP and phospho-extracellular signal-regulated kinase expression, and enhanced the expression of the cell cycle inhibitor p21 as well as of the thyroid transcription factor 1, which is involved in thyroid cell differentiation.	fts	0-3	lectin, galactose binding, soluble 3	Mus musculus	35-40
20682656-7	2010	FTS disrupted interactions between Gal-3 and K.Ras, strongly reduced K-Ras.GTP and phospho-extracellular signal-regulated kinase expression, and enhanced the expression of the cell cycle inhibitor p21 as well as of the thyroid transcription factor 1, which is involved in thyroid cell differentiation.	fts	0-3	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	45-50
20682656-7	2010	FTS disrupted interactions between Gal-3 and K.Ras, strongly reduced K-Ras.GTP and phospho-extracellular signal-regulated kinase expression, and enhanced the expression of the cell cycle inhibitor p21 as well as of the thyroid transcription factor 1, which is involved in thyroid cell differentiation.	fts	0-3	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	69-74
20682656-7	2010	FTS disrupted interactions between Gal-3 and K.Ras, strongly reduced K-Ras.GTP and phospho-extracellular signal-regulated kinase expression, and enhanced the expression of the cell cycle inhibitor p21 as well as of the thyroid transcription factor 1, which is involved in thyroid cell differentiation.	fts	0-3	transcription elongation factor A (SII)-like 1	Mus musculus	197-200
20682656-7	2010	FTS disrupted interactions between Gal-3 and K.Ras, strongly reduced K-Ras.GTP and phospho-extracellular signal-regulated kinase expression, and enhanced the expression of the cell cycle inhibitor p21 as well as of the thyroid transcription factor 1, which is involved in thyroid cell differentiation.	fts	0-3	NK2 homeobox 1	Mus musculus	219-249
18615637-5	2008	S-trans, trans-farnesylthiosalicylic (FTS), which inhibits Galectin-3/MAC-2 dependent activation of PI3K through Ras, inhibited phagocytosis.	fts	38-41	galectin 3	Homo sapiens	59-69
18615637-5	2008	S-trans, trans-farnesylthiosalicylic (FTS), which inhibits Galectin-3/MAC-2 dependent activation of PI3K through Ras, inhibited phagocytosis.	fts	38-41	galectin 3	Homo sapiens	70-75
18615637-6	2008	K-Ras-GTP levels and PI3K activity increased during normal phagocytosis and decreased during FTS-inhibited phagocytosis.	fts	93-96	KRAS proto-oncogene, GTPase	Homo sapiens	0-5
15705901-3	2005	FTS inhibited active Ras and attenuated Ras signaling to extracellular signal-regulated kinase, phosphatidylinositol-3-kinase, and Akt.	fts	0-3	AKT serine/threonine kinase 1	Homo sapiens	131-134
12796721-9	2003	Thus, FTS provided long-term neuroprotection after CHI, rescuing NMDAR binding in the contused hemisphere and profoundly reducing neurologic deficits.	fts	6-9	glutamate receptor, ionotropic, NMDA1 (zeta 1)	Mus musculus	65-70
11055588-7	2000	RESULTS: We demonstrate that FTS treatment alters the morphology and blocks the growth of SW480 and HT-29 colon cancer cells by both reducing the total amount of Ras and up-regulating the tumor suppressor p53.	fts	29-32	tumor protein p53	Homo sapiens	205-208
11055588-8	2000	Furthermore, FTS caused an upregulation of the cyclin-cyclin-dependent kinase (CDK) inhibitor p21(waf1/cip1) and blocked the cell cycle.	fts	13-16	cyclin dependent kinase inhibitor 1A	Homo sapiens	94-107
11055588-9	2000	p53 antisense oligonucleotides not only reduced the level of p53 proteins but correspondingly also blocked the expression of p21(waf1/cip1) in FTS-treated colon cancer cells.	fts	143-146	tumor protein p53	Homo sapiens	0-3
11055588-9	2000	p53 antisense oligonucleotides not only reduced the level of p53 proteins but correspondingly also blocked the expression of p21(waf1/cip1) in FTS-treated colon cancer cells.	fts	143-146	tumor protein p53	Homo sapiens	61-64
11055588-9	2000	p53 antisense oligonucleotides not only reduced the level of p53 proteins but correspondingly also blocked the expression of p21(waf1/cip1) in FTS-treated colon cancer cells.	fts	143-146	cyclin dependent kinase inhibitor 1A	Homo sapiens	125-138