PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31900900-0	2020	Correction to: Comparing the Neuroprotective Effects of Caffeic Acid in Rat Cortical Slices and Caenorhabditis elegans: Involvement of Nrf2 and SKN-1 Signaling Pathways.	Caffeic Acids	56-68	BZIP domain-containing protein;Protein skinhead-1	Caenorhabditis elegans	144-149
31757489-5	2020	The results showed that gallic acid, caffeic acid and ferulic acid had high inhibitory activity at concentration of 150 muM.	Caffeic Acids	37-49	latexin	Homo sapiens	120-123
31773385-6	2020	Quercetin and caffeic acid in old fibroblast cells showed higher clock gene expression than resveratrol, quercetin increased Sirt1 expression, and caffeic acid increased Sirt6 expression indicating the possibility of an anti-aging effect.	Caffeic Acids	14-26	sirtuin 6	Homo sapiens	170-175
31936160-9	2020	Results of molecular docking suggested that caffeic acid bound to P-gp through GLU74 and TRY117 residues.	Caffeic Acids	44-56	ATP binding cassette subfamily B member 1	Homo sapiens	66-70
31773385-6	2020	Quercetin and caffeic acid in old fibroblast cells showed higher clock gene expression than resveratrol, quercetin increased Sirt1 expression, and caffeic acid increased Sirt6 expression indicating the possibility of an anti-aging effect.	Caffeic Acids	147-159	sirtuin 6	Homo sapiens	170-175
31773385-7	2020	Also, quercetin and caffeic acid showed higher clock-controlled gene (Sirt1 and NR1D1) expression than resveratrol in young fibroblast cells.	Caffeic Acids	20-32	sirtuin 1	Homo sapiens	70-75
31773385-7	2020	Also, quercetin and caffeic acid showed higher clock-controlled gene (Sirt1 and NR1D1) expression than resveratrol in young fibroblast cells.	Caffeic Acids	20-32	nuclear receptor subfamily 1 group D member 1	Homo sapiens	80-85
31773385-8	2020	It appears that caffeic acid acts on NRF2 expression, and in turn to the actions of GRalpha, GDF11, Sirt1, and Sirt6.	Caffeic Acids	16-28	NFE2 like bZIP transcription factor 2	Homo sapiens	37-41
31773385-8	2020	It appears that caffeic acid acts on NRF2 expression, and in turn to the actions of GRalpha, GDF11, Sirt1, and Sirt6.	Caffeic Acids	16-28	growth differentiation factor 11	Homo sapiens	93-98
31773385-8	2020	It appears that caffeic acid acts on NRF2 expression, and in turn to the actions of GRalpha, GDF11, Sirt1, and Sirt6.	Caffeic Acids	16-28	sirtuin 1	Homo sapiens	100-105
31773385-8	2020	It appears that caffeic acid acts on NRF2 expression, and in turn to the actions of GRalpha, GDF11, Sirt1, and Sirt6.	Caffeic Acids	16-28	sirtuin 6	Homo sapiens	111-116
31773385-9	2020	Regarding the increased expression of Per1, the activation effect on NR1D1 was confirmed only for caffeic acid in young fibroblast cells.	Caffeic Acids	98-110	nuclear receptor subfamily 1 group D member 1	Homo sapiens	69-74
31936160-10	2020	The present study demonstrated that caffeic acid is a promising candidate for P-gp inhibition and cancer MDR attenuation.	Caffeic Acids	36-48	ATP binding cassette subfamily B member 1	Homo sapiens	78-82
32003651-6	2020	OBJECTIVE: In the present study the in vitro aggregation of human serum albumin (HSA) by using a reactive dicarbonyl glyoxal has been investigated, simultaneously an attempt has been done to inhibit the glyoxal (GO) induced aggregation of (HSA) by caffeic acid (CA).	Caffeic Acids	248-260	albumin	Homo sapiens	66-79
31766098-11	2020	DFSG and a mixture of caffeic acid, p-coumaric acid, and chlorogenic acid inhibited MUC5AC gene expression in A549 cells after stimulation with IL-1beta.	Caffeic Acids	22-34	interleukin 1 beta	Mus musculus	144-152
31936160-0	2020	Caffeic Acid Attenuates Multi-Drug Resistance in Cancer Cells by Inhibiting Efflux Function of Human P-glycoprotein.	Caffeic Acids	0-12	ATP binding cassette subfamily B member 1	Homo sapiens	101-115
31936160-3	2020	The aim of the present study was to investigate the modulating effects and mechanisms of caffeic acid on human P-gp, as well as the attenuating ability on cancer MDR.	Caffeic Acids	89-101	ATP binding cassette subfamily B member 1	Homo sapiens	111-115
31936160-7	2020	In terms of P-gp ATPase activity, caffeic acid exhibited stimulation in both basal and verapamil-stimulated activity.	Caffeic Acids	34-46	ATP binding cassette subfamily B member 1	Homo sapiens	12-16
31936160-8	2020	The combination of chemo drugs and caffeic acid resulted in decreased IC50 in ABCB1/Flp-InTM-293 and KB/VIN, indicating that the resistance was reversed.	Caffeic Acids	35-47	ATP binding cassette subfamily B member 1	Homo sapiens	78-83
31936160-8	2020	The combination of chemo drugs and caffeic acid resulted in decreased IC50 in ABCB1/Flp-InTM-293 and KB/VIN, indicating that the resistance was reversed.	Caffeic Acids	35-47	long intergenic non-protein coding RNA 1191	Homo sapiens	104-107
31766098-11	2020	DFSG and a mixture of caffeic acid, p-coumaric acid, and chlorogenic acid inhibited MUC5AC gene expression in A549 cells after stimulation with IL-1beta.	Caffeic Acids	22-34	mucin 5, subtypes A and C, tracheobronchial/gastric	Mus musculus	84-90
31566891-0	2019	Caffeic acid alkyl amide derivatives ameliorate oxidative stress and modulate ERK1/2 and Akt signaling pathways in a rat model of diabetic retinopathy.	Caffeic Acids	0-24	mitogen activated protein kinase 3	Rattus norvegicus	78-84
31566891-0	2019	Caffeic acid alkyl amide derivatives ameliorate oxidative stress and modulate ERK1/2 and Akt signaling pathways in a rat model of diabetic retinopathy.	Caffeic Acids	0-24	AKT serine/threonine kinase 1	Rattus norvegicus	89-92
31657577-8	2019	With the modified poly(caffeic acid) layer, SP-2 exhibited a different adsorption properties for Methylene Blue (MB, 180 mumol/g) to SP-1(~0 mumol/g), indicating that the tailorable structures of sponge can regulate their selectivity to guest molecules.	Caffeic Acids	18-36	Sp2 transcription factor	Homo sapiens	44-48
28718636-3	2017	We evaluated C4, C14, C16, and C18 alkyl esters of p-coumaric, ferulic, sinapic, and caffeic acids (19 compounds) for their cytotoxic activity against four human cancer cells and also examined their effect on cell cycle alteration and apoptosis induction.	Caffeic Acids	85-98	Bardet-Biedl syndrome 9	Homo sapiens	31-34
31691585-4	2021	trans-Caffeic acid 3, phenylpropanoid 4, and caffeoylquinic acid derivatives 5-9 could inhibit ROS generations induced in human keratinocyte HaCaT cells with IC50 values of 0.94-28.40 muM.	Caffeic Acids	0-18	latexin	Homo sapiens	184-187
31574257-8	2019	We then characterize three compounds, 3"-nitrophthalanilic acid, chlorogenic acid and caffeic acid that affect DPPI activity via kinetic mechanisms consistent with binding outside of the active site.	Caffeic Acids	86-98	cathepsin C	Homo sapiens	111-115
31550730-8	2019	Both BCA and CA decreased P-SQ-induced IL-1beta secretion in HaCaT cells.	Caffeic Acids	5-8	interleukin 1 beta	Homo sapiens	39-47
29270181-8	2017	Sedaxane also improved leaf phenylalanine ammonia-lyase (PAL) activity, which may be responsible for the increase in shoot antioxidant activity (phenolic acids), mainly represented by p-coumaric and caffeic acids.	Caffeic Acids	199-212	phenylalanine ammonia-lyase	Zea mays	57-60
28388092-0	2017	Spectrophotometric Characterization of the Action of Tyrosinase on p-Coumaric and Caffeic Acids: Characteristics of o-Caffeoquinone.	Caffeic Acids	82-95	tyrosinase	Homo sapiens	53-63
28230729-0	2017	Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells.	Caffeic Acids	137-150	protein kinase D1	Homo sapiens	82-85
28230729-0	2017	Catechol Groups Enable Reactive Oxygen Species Scavenging-Mediated Suppression of PKD-NFkappaB-IL-8 Signaling Pathway by Chlorogenic and Caffeic Acids in Human Intestinal Cells.	Caffeic Acids	137-150	C-X-C motif chemokine ligand 8	Homo sapiens	95-99