PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 32057949-7 2020 The interaction between AL049437, miR-205-5p, and mitogen-activated protein kinase 1 (MAPK1) was evaluated using luciferase reporter and RNA pull-down assays. Ephrin-A5 24-32 mitogen-activated protein kinase 1 Homo sapiens 50-84 32057949-7 2020 The interaction between AL049437, miR-205-5p, and mitogen-activated protein kinase 1 (MAPK1) was evaluated using luciferase reporter and RNA pull-down assays. Ephrin-A5 24-32 mitogen-activated protein kinase 1 Homo sapiens 86-91 32057949-10 2020 Furthermore, silencing of AL049437 alleviated MPP+-induced neuroinflammation and oxidative stress, as indicated by the reduction in tumor necrosis factor-alpha and interleukin-6 levels and reactive oxygen species production. Ephrin-A5 26-34 tumor necrosis factor Homo sapiens 132-159 32057949-10 2020 Furthermore, silencing of AL049437 alleviated MPP+-induced neuroinflammation and oxidative stress, as indicated by the reduction in tumor necrosis factor-alpha and interleukin-6 levels and reactive oxygen species production. Ephrin-A5 26-34 interleukin 6 Homo sapiens 164-177 32057949-11 2020 In addition, AL049437 was predominantly localized in the cytoplasm of SH-SY5Y cells and functioned as an miR-205-5p sponge. Ephrin-A5 13-21 microRNA 205 Homo sapiens 105-112 32057949-13 2020 Remarkably, the impact of AL049437 silencing on MPP+-induced neuronal damage could be blocked by miR-205-5p inhibition or MAPK1 overexpression. Ephrin-A5 26-34 microRNA 205 Homo sapiens 97-104 32057949-13 2020 Remarkably, the impact of AL049437 silencing on MPP+-induced neuronal damage could be blocked by miR-205-5p inhibition or MAPK1 overexpression. Ephrin-A5 26-34 mitogen-activated protein kinase 1 Homo sapiens 122-127