PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33585770-6 2021 Notably, the fog-harvesting efficiency of all VFMs increased by 30-80% after spraying with the mixed PU-SA solution to form a 3D geometric surface structure (3D PU-SA microbumps), which mimicked the desert beetle back surface. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 104-106 zinc finger protein, FOG family member 1 Homo sapiens 13-16 33585770-6 2021 Notably, the fog-harvesting efficiency of all VFMs increased by 30-80% after spraying with the mixed PU-SA solution to form a 3D geometric surface structure (3D PU-SA microbumps), which mimicked the desert beetle back surface. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 164-166 zinc finger protein, FOG family member 1 Homo sapiens 13-16 33633438-13 2021 Results: SA-2 upregulated cGMP levels (six- to ten-fold) with an half maximal effective concentration (EC50) of 20.3 microM in the hTM cells and simultaneously upregulated (40-fold) the SOD enzyme when compared with the vehicle-treated hTM cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 superoxide dismutase 1 Homo sapiens 186-189 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 174-176 hypoxia inducible factor 1 subunit alpha a Danio rerio 46-56 33125520-12 2021 In the whole population, subcutaneous adipose tissue SA-beta-gal activity was positively associated with serum leptin, markers of insulin resistance and increased trunk fat mass. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 53-55 leptin Homo sapiens 111-117 33125520-12 2021 In the whole population, subcutaneous adipose tissue SA-beta-gal activity was positively associated with serum leptin, markers of insulin resistance and increased trunk fat mass. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 53-55 insulin Homo sapiens 130-137 34053052-2 2021 Senescence of CD8+ T-cells has been described in all these conditions.The most important classical markers of T senescent cells are the cell cycle inhibitors p16ink4a, p21, and p53, together with positivity for SA-betagal expression and the acquirement of a peculiar IFNgamma -based secretory phenotype commonly defined SASP (Senescence Associated Secretory Phenotype). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 211-213 CD8a molecule Homo sapiens 14-17 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 174-176 caveolin 1 Danio rerio 124-129 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 174-176 hypoxia inducible factor 1 subunit alpha a Danio rerio 229-239 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 174-176 caveolin 1 Danio rerio 240-245 33381039-11 2020 In both mouse breast cancer xenograft and zebrafish xenotransplantation models, SA inhibited breast cancer growth and inhibited late-phase autophagy in vivo, which was accompanied by suppression of Hif-1alpha/Cav-1 signaling and the epithelial-mesenchymal transition. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 80-82 hypoxia inducible factor 1 subunit alpha a Danio rerio 198-208 33381039-11 2020 In both mouse breast cancer xenograft and zebrafish xenotransplantation models, SA inhibited breast cancer growth and inhibited late-phase autophagy in vivo, which was accompanied by suppression of Hif-1alpha/Cav-1 signaling and the epithelial-mesenchymal transition. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 80-82 caveolin 1 Danio rerio 209-214 33381039-12 2020 Overall, our findings not only indicate that SA acts as a novel late-phase autophagic inhibitor with anti-metastatic activities in triple-negative breast cancer, but also highlight Cav-1 as a regulator in controlling late-phase autophagic activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 45-47 caveolin 1 Danio rerio 181-186 33302398-7 2020 Variations in SA composition were correlated to the differential expression of several Arabidopsis 3-ketoacyl-CoAsynthase (KCS) genes, including KCS1, KCS5, KCS6, KCS8, and KCS12, a lipid transfer protein (LTPG1) and a lipase (LIP1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 3-ketoacyl-CoA synthase 1 Arabidopsis thaliana 145-149 33302398-7 2020 Variations in SA composition were correlated to the differential expression of several Arabidopsis 3-ketoacyl-CoAsynthase (KCS) genes, including KCS1, KCS5, KCS6, KCS8, and KCS12, a lipid transfer protein (LTPG1) and a lipase (LIP1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 3-ketoacyl-CoA synthase 5 Arabidopsis thaliana 151-155 33302398-7 2020 Variations in SA composition were correlated to the differential expression of several Arabidopsis 3-ketoacyl-CoAsynthase (KCS) genes, including KCS1, KCS5, KCS6, KCS8, and KCS12, a lipid transfer protein (LTPG1) and a lipase (LIP1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 3-ketoacyl-CoA synthase 6 Arabidopsis thaliana 157-161 33302398-7 2020 Variations in SA composition were correlated to the differential expression of several Arabidopsis 3-ketoacyl-CoAsynthase (KCS) genes, including KCS1, KCS5, KCS6, KCS8, and KCS12, a lipid transfer protein (LTPG1) and a lipase (LIP1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 3-ketoacyl-CoA synthase 8 Arabidopsis thaliana 163-167 33302398-7 2020 Variations in SA composition were correlated to the differential expression of several Arabidopsis 3-ketoacyl-CoAsynthase (KCS) genes, including KCS1, KCS5, KCS6, KCS8, and KCS12, a lipid transfer protein (LTPG1) and a lipase (LIP1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 glycosylphosphatidylinositol-anchored lipid protein transfer 1 Arabidopsis thaliana 206-211 33302398-7 2020 Variations in SA composition were correlated to the differential expression of several Arabidopsis 3-ketoacyl-CoAsynthase (KCS) genes, including KCS1, KCS5, KCS6, KCS8, and KCS12, a lipid transfer protein (LTPG1) and a lipase (LIP1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 Ras-related small GTP-binding family protein Arabidopsis thaliana 227-231 33069038-9 2020 Then, we observed that the expression of ICS1, a key gene in SA biosynthesis, was greatly suppressed in AtMYB109-OXs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 61-63 ADC synthase superfamily protein Arabidopsis thaliana 41-45 33069038-9 2020 Then, we observed that the expression of ICS1, a key gene in SA biosynthesis, was greatly suppressed in AtMYB109-OXs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 61-63 myb domain protein 109 Arabidopsis thaliana 104-112 33069038-13 2020 Taken together, we suggest the delayed stomatal closing and vulnerable phenotypes in the AtMYB109-OXs under osmotic stress are possibly directly or indirectly associated with a SA-mediated mechanism, and that AtMYB109 suppresses RABA4D that modulates pollen tube growth. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 177-179 myb domain protein 109 Arabidopsis thaliana 89-97 33069038-13 2020 Taken together, we suggest the delayed stomatal closing and vulnerable phenotypes in the AtMYB109-OXs under osmotic stress are possibly directly or indirectly associated with a SA-mediated mechanism, and that AtMYB109 suppresses RABA4D that modulates pollen tube growth. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 177-179 RAB GTPase homolog A4D Arabidopsis thaliana 229-235 32531350-6 2020 Results demonstrate that both cocrystals enhance SA by orders of magnitude (20 to 100 times for the SLC and over 300 times for the MLE cocrystal) in the pH range of 1.6 to 6.5. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 49-51 C-C motif chemokine ligand 21 Homo sapiens 100-103 33172992-4 2020 As a result, the pressurized ENRR activity of Rh SA/GDY at 55 atm exhibited a record-high NH3 formation rate of 74.15 mug h-1 cm-2, a Faraday efficiency of 20.36%, and a NH3 partial current of 0.35 mA cm-2 at -0.20 V versus reversible hydrogen electrode, which, respectively, displayed 7.3-, 4.9-, and 9.2-fold enhancements compared with those obtained under ambient conditions. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 49-51 H1.5 linker histone, cluster member Homo sapiens 122-130 32952639-5 2020 The results of the current study demonstrated that IGF-1 promoted cellular senescence in rat articular chondrocytes via activation of SA-beta-gal and the upregulation of p53 and p21 mRNA and protein levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 134-136 insulin-like growth factor 1 Rattus norvegicus 51-56 32954049-5 2021 In terms of in vitro tests, the Rb-SA/PAAm gels not only show nontoxicity to human keratinocyte cell line (Hacats) but also inhibits the activity against inflammatory NF-kappabeta signaling pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 35-37 nuclear factor kappa B subunit 1 Homo sapiens 167-179 32869029-9 2020 The availability of a conceptually simple MMGB/SA-based protocol for analysis of the SARS-CoV-2 /ACE2 binding may be beneficial in light of the need to move forward fast. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 angiotensin converting enzyme 2 Homo sapiens 97-101 33381039-6 2020 Network and biological analyses predicted that SA mainly targeted caveolin-1 (Cav-1) to induce anti-metastatic effects, and one of the core mechanisms was via regulation of autophagy. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 caveolin 1 Danio rerio 78-83 33381039-8 2020 Furthermore, the anti-autophagic and anti-metastatic activity of SA was Cav-1-dependent. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 65-67 caveolin 1 Danio rerio 72-77 33381039-9 2020 Specifically, Cav-1 knockdown significantly facilitated SA-mediated inhibition of autophagy and metastasis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 caveolin 1 Danio rerio 14-19 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 hypoxia inducible factor 1 subunit alpha a Danio rerio 46-56 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 caveolin 1 Danio rerio 124-129 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 hypoxia inducible factor 1 subunit alpha a Danio rerio 229-239 33381039-10 2020 Furthermore, hypoxia inducible factor-1alpha (Hif-1alpha) overexpression attenuated the SA-induced inhibitory activities on Cav-1, autophagy, and metastasis, indicating that SA may have inhibited autophagy-related metastasis via Hif-1alpha/Cav-1 signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 caveolin 1 Danio rerio 240-245 32828822-5 2020 In this study, we developed a new vaccine strain, O/SKR/Boeun/2017 isolate, belonging to the O/ME-SA/Ind-2001e sublineage as an outbreak of this sublineage occurred in 2017 in the Boeun county of the Republic of Korea (O/SKR/Boeun/2017). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 98-100 tachykinin receptor 2 Homo sapiens 52-55 32918374-10 2020 Overexpression of IMP1 reduced p21 and SA-beta-gal to inhibit the senescence of alveolar epithelial cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 39-41 insulin-like growth factor 2 mRNA binding protein 1 Rattus norvegicus 18-22 32412100-5 2020 KEY FINDINGS: Radiation reduced superoxide dismutase (SOD) activity and expressions of cyclin-dependent kinase (CDK2), CDK4, cyclin E and transcription factor E2F1 proteins, and increased expressions of p21, p16, cyclin D and retinoblastoma (RB) proteins, malondialdehyde (MDA) activity, SA-beta-gal-positive cells and cells stagnating in G1 phase. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 288-290 superoxide dismutase 1 Homo sapiens 54-57 32849736-11 2020 Expression of the CiLV-C P61 protein consistently triggered ROS burst, upregulated SA- and HR-related genes, increased SA levels, reduced JA levels, and caused cell death. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 83-85 p61 Citrus leprosis virus C 25-28 32849736-11 2020 Expression of the CiLV-C P61 protein consistently triggered ROS burst, upregulated SA- and HR-related genes, increased SA levels, reduced JA levels, and caused cell death. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 119-121 p61 Citrus leprosis virus C 25-28 32437790-6 2020 KEY FINDINGS: Rg1 played an anti-aging role in reversing d-galactose induced increase in senescence-associated SA-beta-gal staining and p53, p21 protein in hepatocytes of mice and sustained mitochondria homeostasis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 111-113 protein phosphatase 1, regulatory subunit 3A Mus musculus 14-17 32527091-2 2020 The gas-phase complex with Cl- was found to be a tailor-made for the macrocycle 1, while 1+SA- (SA- = salicylate anion) and 1+HSO4- were the weakest ones. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 PAXIP1 associated glutamate rich protein 1 Homo sapiens 4-7 32722183-5 2020 The current study hypothesizes that the cardioprotective effects of the synthetic EDP surrogates AS-27, SA-26 and AA-4 against IR injury involve activation of SIRT3. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 104-106 sirtuin 3 Mus musculus 159-164 32722183-8 2020 Assessment of cardiac mitochondria demonstrated SA-26 preserved SIRT3 activity and reduced acetylation of manganese superoxide dismutase (MnSOD) suggesting enhanced antioxidant capacity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-51 sirtuin 3 Mus musculus 64-69 32527091-2 2020 The gas-phase complex with Cl- was found to be a tailor-made for the macrocycle 1, while 1+SA- (SA- = salicylate anion) and 1+HSO4- were the weakest ones. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 96-98 PAXIP1 associated glutamate rich protein 1 Homo sapiens 4-7 32475548-7 2020 These results reveal the great potential of SA as a carrier for conjugating anti-tumor drugs and 1-SA1 for TAMs-targeted PDT. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 44-46 stromal antigen 1 Homo sapiens 99-102 32385404-8 2020 We found that Exl1 acts on the plant tissue, probably by remodelling of a cell wall component or altering the barrier properties of the cell wall inducing a plant defence response, which results in the production of ROS and the induction of marker genes of the JA, ET and SA signalling pathways in Arabidopsis thaliana. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 272-274 Phosphate-responsive 1 family protein Arabidopsis thaliana 14-18 32600760-3 2020 In the absence of DAN, the mAb-Bio-SA-Bio-GOx would be immobilized by combining with coated DAN-BSA and catalyzed glucose to generate H2O2. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 35-37 hydroxyacid oxidase 1 Homo sapiens 42-45 32493904-4 2020 Mechanistically, this LD accumulation during aging is not linked to NAD+ levels, but is anti-correlated with metabolites of the shikimate and aromatic amino acid biosynthesis (SA) pathways (upstream of BNA2), which produce tryptophan (the Bna2p substrate). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 176-178 dioxygenase BNA2 Saccharomyces cerevisiae S288C 202-206 32493904-5 2020 We provide evidence that over-expressed BNA2 skews glycolytic flux from LDs towards the SA-BNA pathways, effectively reducing LDs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 dioxygenase BNA2 Saccharomyces cerevisiae S288C 40-44 32508858-6 2020 This review highlights the role of AC2/C2 in affecting the jasmonic acid and salicylic acid (JA and SA) pathways, the ubiquitin/proteasome system (UPS), and RNA silencing pathways. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 100-102 adenylate cyclase 2 Homo sapiens 35-38 32195564-3 2020 Compared to pure PAM gel, the tensile strength and compressive strength of Zn-reinforced SA-PAM SE are significantly enhanced to be 674.28 kPa and 16.29 MPa, respectively, due to the strengthening mechanism of Zn2+ cross-linked SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 89-91 peptidylglycine alpha-amidating monooxygenase Homo sapiens 17-20 32092035-5 2020 A robust NF-kappaB activation was seen at E20-E40 of tumour development accompanied by a marked SA-beta-Gal co-reactivity in the tumour pituitary parenchyma. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 96-98 nuclear factor kappa B subunit 1 Homo sapiens 9-18 32388422-2 2020 Several SA-binding proteins, including SABP2 (salicylic acid-binding protein 2) has been identified and characterized for their role in plant disease resistance. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 8-10 salicylic acid-binding protein 2 Nicotiana tabacum 39-44 32388422-2 2020 Several SA-binding proteins, including SABP2 (salicylic acid-binding protein 2) has been identified and characterized for their role in plant disease resistance. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 8-10 salicylic acid-binding protein 2 Nicotiana tabacum 46-78 32388422-10 2020 SIP428 shows homology to Arabidopsis AtSRT2 (67% identity), which is implicated in SA-mediated basal defenses. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 83-85 sirtuin 2 Arabidopsis thaliana 37-43 32195564-3 2020 Compared to pure PAM gel, the tensile strength and compressive strength of Zn-reinforced SA-PAM SE are significantly enhanced to be 674.28 kPa and 16.29 MPa, respectively, due to the strengthening mechanism of Zn2+ cross-linked SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 89-91 peptidylglycine alpha-amidating monooxygenase Homo sapiens 92-95 32188324-6 2022 dNK cells from PE pregnancies not only killed first trimester trophoblasts but also inhibited their invasion and migration when compared to normal controls.Conclusion: Our results suggest that NK cells, in conjunction with EVTs, may play an important role in controlling uterine SA remodeling at the early stages of vessel remodeling, but they contribute to the pathogenesis of PE in late pregnancy. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 279-281 deoxyribonucleoside kinase Drosophila melanogaster 0-3 32778623-17 2020 This change results in electrophysiological remodeling of the heart, as seen in the VLP image on SA-ECG. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 97-99 VHL like Homo sapiens 84-87 32257630-12 2020 Results also explore that SA up to 0.2 mM SA applied on plant foliage improved LAI (5-13%), photosynthesis (4-27%), WUE (11-57%), dry weight (5-20%), SOD activity (4-20%) and finally fruit yield (4-20%) compared to untreated plants by ameliorating effect of 60 mM NaCl. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 superoxide dismutase 1 Homo sapiens 150-153 32257630-12 2020 Results also explore that SA up to 0.2 mM SA applied on plant foliage improved LAI (5-13%), photosynthesis (4-27%), WUE (11-57%), dry weight (5-20%), SOD activity (4-20%) and finally fruit yield (4-20%) compared to untreated plants by ameliorating effect of 60 mM NaCl. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 42-44 superoxide dismutase 1 Homo sapiens 150-153 32257630-13 2020 Foliar application of SA also caused significant increase in nutrient use efficiency due to significant variations in POD and SOD activities. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 22-24 superoxide dismutase 1 Homo sapiens 126-129 32257630-15 2020 Foliar application of SA upgraded SOD by lowering POD activity to improve NUE particularly K use efficiency at salinity stress of 60 mM NaCl. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 22-24 superoxide dismutase 1 Homo sapiens 34-37 32188324-6 2022 dNK cells from PE pregnancies not only killed first trimester trophoblasts but also inhibited their invasion and migration when compared to normal controls.Conclusion: Our results suggest that NK cells, in conjunction with EVTs, may play an important role in controlling uterine SA remodeling at the early stages of vessel remodeling, but they contribute to the pathogenesis of PE in late pregnancy. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 279-281 deoxyribonucleoside kinase Drosophila melanogaster 1-3 32258120-6 2020 Levels of oxidative stress markers, glutathione-peroxidase, superoxide dismutase, and catalase, in the cardiac tissue were significantly increased, whereas malondialdehyde levels decreased after SA treatment in DOX-administered rats. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 195-197 catalase Rattus norvegicus 86-94 32258120-8 2020 Daily administration of SA significantly repressed TNF-alpha, IL-1beta, ET-1, and NF-kappaB levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 tumor necrosis factor Rattus norvegicus 51-60 32258120-8 2020 Daily administration of SA significantly repressed TNF-alpha, IL-1beta, ET-1, and NF-kappaB levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 interleukin 1 alpha Rattus norvegicus 62-70 32258120-8 2020 Daily administration of SA significantly repressed TNF-alpha, IL-1beta, ET-1, and NF-kappaB levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 endothelin 1 Rattus norvegicus 72-76 32194589-6 2020 Defense marker gene expression profiling of mock- and virus-inoculated plants showed that med18 and med25 mutants exhibited an upregulated SA pathway upon virus infection at 2 dpi for all viruses tested. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 139-141 mediator of RNA polymerase II transcription subunit Arabidopsis thaliana 90-95 32194589-6 2020 Defense marker gene expression profiling of mock- and virus-inoculated plants showed that med18 and med25 mutants exhibited an upregulated SA pathway upon virus infection at 2 dpi for all viruses tested. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 139-141 phytochrome and flowering time regulatory protein (PFT1) Arabidopsis thaliana 100-105 32099739-7 2020 The expression of CHS7 and CHS8 by 10 muM SA at R7 level revealed maximum up-regulation of 0.51- and 1.01-fold in MAUS-2; 0.37- and 0.82-fold in JS-335, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 42-44 chalcone synthase 7 Glycine max 18-22 32099739-7 2020 The expression of CHS7 and CHS8 by 10 muM SA at R7 level revealed maximum up-regulation of 0.51- and 1.01-fold in MAUS-2; 0.37- and 0.82-fold in JS-335, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 42-44 chalcone synthase Glycine max 27-31 31535208-9 2020 (3) The expression of p38MAPK mRNA and protein was significantly decreased, while nephrin and podocin mRNA and protein were significantly higher in Group Sa than those in Group DM after 12 weeks. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 154-156 NPHS2 stomatin family member, podocin Rattus norvegicus 94-101 31535208-9 2020 (3) The expression of p38MAPK mRNA and protein was significantly decreased, while nephrin and podocin mRNA and protein were significantly higher in Group Sa than those in Group DM after 12 weeks. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 154-156 NPHS1 adhesion molecule, nephrin Rattus norvegicus 82-89 32019182-6 2020 When examining the relative contributions to sequence conservation of the globular head versus stalk domains of the RBP, we observe that, for the protein-using PMVs, the stalk domains exhibit higher conservation and find the opposite trend is true for SA-using PMVs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 252-254 retinol binding protein 4 Homo sapiens 116-119 31730896-7 2020 In vitro experiment confirmed that IL-10 could induce senescence of activated HSCs via inhibiting cell proliferation, inducing cell cycle arrest, increasing the SA-beta-Gal activity and enhancing expression of senescence marker protein p53 and p21. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 161-163 interleukin 10 Rattus norvegicus 35-40 31490429-12 2020 SA only led to an elevation (15%) in TES in POST. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 solute carrier family 35 member G1 Homo sapiens 44-48 31398611-4 2019 Batch experiments were carried out to explore the adsorption performance and the results displayed that the enhanced adsorption capacity was achieved by Al-MOF/SA-CS beads compared to the Al-MOF/SA ones. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 160-162 lysine acetyltransferase 8 Homo sapiens 156-159 32095048-9 2019 Results: Prothrombin time, partial thromboplastin time, and clotting time significantly increased only in groups treated with SAS, especially at the dosage of 1428 mg/kg compared with the positive control group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 126-129 coagulation factor II Mus musculus 9-20 31518626-5 2019 SA/CdS-2 (mass ratio SA: CdS = 1:2) exhibited the highest reduction efficiency of Cr (VI), which could reduce the concentration of Cr (VI) to 0 mg/L after 60 min illumination. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 CDP-diacylglycerol synthase 2 Homo sapiens 3-8 31518626-5 2019 SA/CdS-2 (mass ratio SA: CdS = 1:2) exhibited the highest reduction efficiency of Cr (VI), which could reduce the concentration of Cr (VI) to 0 mg/L after 60 min illumination. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 21-23 CDP-diacylglycerol synthase 2 Homo sapiens 3-8 31400580-7 2019 Moreover, the results showed that HM-7 cells, co-cultured with VA or SA from obese subjects, expressed higher levels of fatty acid binding protein 4; thus, the conditioned media obtained from the wells contained HM-7 cells and adipocytes from obese subjects was significantly more efficient in promoting invasion of HM-7 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 69-71 fatty acid binding protein 4 Homo sapiens 120-148 31311650-2 2019 Previous studies showed that WRKY30 expression was induced by oxidative stress treatment, fungal elicitor, SA and ABA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 WRKY DNA-binding protein 30 Arabidopsis thaliana 29-35 31484173-4 2019 As two model drugs, bovine serum albumin (BSA) and ibuprofen (IBU) were separately loaded in SA layer and MBG/SA layer, resulting in a relatively fast release of BSA and a sustained release of IBU. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 43-45 albumin Homo sapiens 27-40 31111491-3 2019 We found that SA acts as a signal molecule for BIR1 activation during infection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 potassium inwardly rectifying channel subfamily J member 6 Homo sapiens 47-51 30735289-5 2019 Vinculin staining demonstrated how the Sa value affected cellular attachment to the substrate. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 39-41 vinculin Mus musculus 0-8 30735289-7 2019 qRT-PCR revealed that Runx2 expression was highest on day 16 on surfaces with Sa of 0.6 mum and 1.1 mum. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 78-80 runt related transcription factor 2 Mus musculus 22-27 31214209-8 2019 Furthermore, our study revealed that enhanced transcription of some SA-dependent genes (NPR1, StWRKY1, and PR1) was not directly linked with DNA methylation changes in the promoter region of these genes, but was a consequence of methylation-dependent alterations in the transcriptional network. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 68-70 probable WRKY transcription factor 75-like Solanum tuberosum 94-101 31423217-6 2019 We established clones of uLMS cells (SKN cells) and uterine sarcoma cells (MES-SA cells) that overexpressed CBR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 79-81 carbonyl reductase 1 Homo sapiens 108-112 31128694-4 2019 We applied a reverse genetics approach to investigate the phenotypes of transgenic plants and mutant plants, and the results showed that the overexpression of AtSPX1 accelerated leaf senescence, suppressed Pi accumulation, promoted SA production and H2O2 levels in leaves, while the mutant lines of AtSPX1 showed slightly delayed leaf senescence. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 232-234 SPX domain-containing protein 1 Arabidopsis thaliana 159-165 31128694-6 2019 The 558 genes that were up-regulated in the overexpression plants 35S::AtSPX1/WT, were significantly enriched in the process of leaf senescence, Pi starvation responses and SA signaling pathways, as were the target genes of some transcription factors such as WRKYs and NACs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 173-175 SPX domain-containing protein 1 Arabidopsis thaliana 71-77 31128694-7 2019 In a word, we characterized AtSPX1 as a key regulator, which mediated the crosstalks among leaf senescence, Pi starvation and SA signaling pathways in Arabidopsis thaliana. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 126-128 SPX domain-containing protein 1 Arabidopsis thaliana 28-34 31460385-4 2019 The hydrogels were prepared by alkali-induced polymerization of DA followed by complexation with SA in PAM networks. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 97-99 peptidylglycine alpha-amidating monooxygenase Homo sapiens 103-106 30902393-10 2019 Aging markers (SA-beta-Gal staining and the protein levels of p16, p53, p21) were significantly changed in the hsp27 decreased group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 heat shock protein family B (small) member 1 Rattus norvegicus 111-116 31089436-8 2019 Furthermore, butyrate and propionate, but not acetate, inhibited Sa.LPP-induced activation of NF-kappaB, expression of IFN-beta, and phosphorylation of STAT1, which are essential for inducing transcription of iNOS in macrophages. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 65-67 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 94-103 31089436-8 2019 Furthermore, butyrate and propionate, but not acetate, inhibited Sa.LPP-induced activation of NF-kappaB, expression of IFN-beta, and phosphorylation of STAT1, which are essential for inducing transcription of iNOS in macrophages. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 65-67 interferon beta 1, fibroblast Mus musculus 119-127 31089436-8 2019 Furthermore, butyrate and propionate, but not acetate, inhibited Sa.LPP-induced activation of NF-kappaB, expression of IFN-beta, and phosphorylation of STAT1, which are essential for inducing transcription of iNOS in macrophages. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 65-67 signal transducer and activator of transcription 1 Mus musculus 152-157 30583016-9 2019 Treatment with diacerein by itself and diacerein in combination with SM/SA stimulation reduced phosphorylation of FAK and STAT3, which is more pronounced in OA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 protein tyrosine kinase 2 Homo sapiens 114-117 30583016-9 2019 Treatment with diacerein by itself and diacerein in combination with SM/SA stimulation reduced phosphorylation of FAK and STAT3, which is more pronounced in OA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 signal transducer and activator of transcription 3 Homo sapiens 122-127 30909287-4 2019 Furthermore, Snakin-1 silencing enhanced salicylic acid content in accordance with an increased expression of SA-inducible PRs genes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 110-112 STSN1 Solanum tuberosum 13-21 30934545-6 2019 Moreover, SA enhanced glycogen synthesis of liver but not muscle via increasing GCK and PEPCK gene expressions. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 glucokinase Mus musculus 80-83 30934545-6 2019 Moreover, SA enhanced glycogen synthesis of liver but not muscle via increasing GCK and PEPCK gene expressions. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 phosphoenolpyruvate carboxykinase 1, cytosolic Mus musculus 88-93 30624837-1 2019 Nanochitosan/sodium alginate (NCS/SA) beads were prepared using nanochitosan and alginate as a high-performance absorbent for Pb(II) removal from aqueous solution. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 submaxillary gland androgen regulated protein 3B Homo sapiens 126-132 31089436-6 2019 Butyrate and propionate inhibited Sa.LPP-induced expression of inducible NO synthase (iNOS). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 nitric oxide synthase 2, inducible Mus musculus 63-84 31089436-6 2019 Butyrate and propionate inhibited Sa.LPP-induced expression of inducible NO synthase (iNOS). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 nitric oxide synthase 2, inducible Mus musculus 86-90 30599309-7 2019 Particularly the pretreatment with 1 mM SA significantly improved the activity of GST and led to the upregulation of GST1, GST2, GST3, and P450 expression levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 glutathione S-transferase Solanum lycopersicum 82-85 30595379-9 2019 Results showed that insulin receded cellular senescence in different time and concentration, as indicated by decreased expression of p21, increased expression of cyclinE and down-regulated ratio of SA-beta-Gal stained cells in BEAS-2B and HSAEpiC under physiological or CSE exposure condition. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 198-200 insulin Homo sapiens 20-27 30711516-12 2019 Importantly, lysosomal pathway contributed to SA-49-mediated down-regulation of PD-L1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 CD274 antigen Mus musculus 80-85 30711516-16 2019 INTERPRETATION: Our data demonstrate that SA-49 can be used to regulate PD-L1 in cancer cells and trigger its degradation by activating lysosome function. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 42-44 CD274 antigen Mus musculus 72-77 30655875-3 2019 The results demonstrated that ginsenoside Rg3 led to cell proliferation arrest; ginsenoside Rg3 decreased the number of cells and increased the positive SA-beta-gal staining rate in PC3 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 153-155 chromobox 8 Homo sapiens 182-185 30187446-3 2018 The developed PEGylated SA lipoplexes (pegSA lipoplexes) showed a lower N/P ratio (1.5) for BMP-9 gene complexation while maintaining the SUV character with a unique shape (square and triangular lipoplexes). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 growth differentiation factor 2 Mus musculus 92-97 30240931-4 2018 Treatment of plants with SA, JA and SA+JA improved H+-ATPase activity and ATP content in root cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 25-27 plasma membrane ATPase 4 Glycine max 51-60 30240931-4 2018 Treatment of plants with SA, JA and SA+JA improved H+-ATPase activity and ATP content in root cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 plasma membrane ATPase 4 Glycine max 51-60 30465670-1 2018 Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-84 catalase Homo sapiens 128-136 30465670-1 2018 Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-84 catalase Homo sapiens 138-141 30465670-1 2018 Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-84 superoxide dismutase 1 Homo sapiens 147-167 30465670-1 2018 Atomically dispersed Fe-N4 sites anchored on N-doped porous carbon materials (Fe-SAs/NC) can mimic two antioxidative enzymes of catalase (CAT) and superoxide dismutase (SOD), and therefore serves as a bifunctional single-atom-based enzyme (SAzyme) for scavenging reactive oxygen species (ROS) to remove excess ROS generated during oxidative stress in cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-84 superoxide dismutase 1 Homo sapiens 169-172 30396118-1 2018 Arabidopsis AP2 FAMILY PROTEIN INVOLVED IN DISEASE DEFENSE (APD1) is a member of AP2/EREBP super-family that positively regulates SA biosynthesis and defense against virulent bacterial pathogens. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 12-15 30396118-1 2018 Arabidopsis AP2 FAMILY PROTEIN INVOLVED IN DISEASE DEFENSE (APD1) is a member of AP2/EREBP super-family that positively regulates SA biosynthesis and defense against virulent bacterial pathogens. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 RING/U-box superfamily protein Arabidopsis thaliana 60-64 30396118-1 2018 Arabidopsis AP2 FAMILY PROTEIN INVOLVED IN DISEASE DEFENSE (APD1) is a member of AP2/EREBP super-family that positively regulates SA biosynthesis and defense against virulent bacterial pathogens. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 81-84 30396118-1 2018 Arabidopsis AP2 FAMILY PROTEIN INVOLVED IN DISEASE DEFENSE (APD1) is a member of AP2/EREBP super-family that positively regulates SA biosynthesis and defense against virulent bacterial pathogens. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 ethylene-responsive element binding factor 13 Arabidopsis thaliana 85-90 30503524-5 2018 The incidence of ABMR was 3.6% (8 of 220) overall, and C3d-DSA-positive KTRs had a significantly higher incidence than SA-DSA-positive KTRs (63.3% vs 38.9%, P = .03). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 60-62 endogenous retrovirus group K member 13 Homo sapiens 55-58 30482886-6 2018 Furthermore, TGF-beta treatment leads to high positive ratio of SA-beta-gal, indicating B4G12 cells undergo cellular senescence. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 transforming growth factor alpha Homo sapiens 13-21 30457616-4 2018 In this work, on the basis of more recently solved X-ray crystallographic structure of hSERT in complex with escitalopram, 3 mus long all-atom MD simulations and binding free energy calculations via MM/GB(PB)SA, thermodynamic integration (TI) and MM/3D-RISM methods were performed to reproduce experimental free energies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 208-210 solute carrier family 6 member 4 Homo sapiens 87-92 30208656-3 2018 In Arabidopsis, AtWRKY11 and AtWRKY70 genes were involved in JA- and SA-induced resistance to pathogens, in rapeseed (Brassica napus L.), BnWRKY11 and BnWRKY70 genes were found to be differently expressed after inoculated with the pathogenic fungus, Sclerotinia sclerotiorum (Lib.) 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 69-71 WRKY DNA-binding protein 11 Arabidopsis thaliana 16-24 30009905-5 2018 Moreover, the catalytic activity of Pd@Hal-SA was higher than that of Pd@Hal + SA, implying that the use of hybrid system was more efficient that use of individual components in a separated form, due to the synergism between SA and Hal. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 43-45 histidine ammonia-lyase Homo sapiens 39-42 30616781-8 2019 Furthermore, CAFs co-cultured with SAS, a poorly differentiated OSCC cell line, or stimulated with IL-1beta exhibit increased CXCL1 secretion in an NF-kappaB-dependent manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 35-38 C-X-C motif chemokine ligand 1 Homo sapiens 126-131 29803744-3 2018 Oxidative stress has long been considered to be harmful to cells, nevertheless, in this study, we found that lower concentration of hydrogen peroxide (H2O2) decreased the number of SA-betagal-immunopositive cells, which was ameliorated by inhibition of SIRT1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 181-183 sirtuin 1 Homo sapiens 253-258 29636243-6 2018 RESULTS: Sa was 4.9+-0.9, 22.1+-4.2 and 44.2+-4.0mum in the Control, Soft and Hard groups, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 POC1 centriolar protein A Homo sapiens 69-73 30208656-3 2018 In Arabidopsis, AtWRKY11 and AtWRKY70 genes were involved in JA- and SA-induced resistance to pathogens, in rapeseed (Brassica napus L.), BnWRKY11 and BnWRKY70 genes were found to be differently expressed after inoculated with the pathogenic fungus, Sclerotinia sclerotiorum (Lib.) 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 69-71 WRKY DNA-binding protein 70 Arabidopsis thaliana 29-37 30208656-3 2018 In Arabidopsis, AtWRKY11 and AtWRKY70 genes were involved in JA- and SA-induced resistance to pathogens, in rapeseed (Brassica napus L.), BnWRKY11 and BnWRKY70 genes were found to be differently expressed after inoculated with the pathogenic fungus, Sclerotinia sclerotiorum (Lib.) 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 69-71 probable WRKY transcription factor 11 Brassica napus 138-146 30208656-3 2018 In Arabidopsis, AtWRKY11 and AtWRKY70 genes were involved in JA- and SA-induced resistance to pathogens, in rapeseed (Brassica napus L.), BnWRKY11 and BnWRKY70 genes were found to be differently expressed after inoculated with the pathogenic fungus, Sclerotinia sclerotiorum (Lib.) 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 69-71 probable WRKY transcription factor 70 Brassica napus 151-159 30166110-13 2018 ATE-Hex reduced the rhodamine efflux in MES-SA/Dx5 cells, indicating that ATE-Hex could reduce the expression of P-gp. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 44-46 hematopoietically expressed homeobox Homo sapiens 4-7 30166110-5 2018 PURPOSE: In this study we investigated the antitumor effects of the hexane fraction of the adlay testa ethanolic extracts (ATE-Hex) on the human uterine sarcoma cancer cell line MES-SA, as well as on the multidrug-resistant human uterine sarcoma cancer cell line MES-SA/Dx5. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 182-184 hematopoietically expressed homeobox Homo sapiens 127-130 30083177-0 2018 Corrigendum: Arabidopsis PCaP2 Functions as a Linker Between ABA and SA Signals in Plant Water Deficit Tolerance. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 69-71 microtubule-associated protein 18 Arabidopsis thaliana 25-30 30166110-13 2018 ATE-Hex reduced the rhodamine efflux in MES-SA/Dx5 cells, indicating that ATE-Hex could reduce the expression of P-gp. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 44-46 hematopoietically expressed homeobox Homo sapiens 78-81 30166110-13 2018 ATE-Hex reduced the rhodamine efflux in MES-SA/Dx5 cells, indicating that ATE-Hex could reduce the expression of P-gp. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 44-46 phosphoglycolate phosphatase Homo sapiens 113-117 28956310-2 2018 Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibroblasts and lens epithelial cells, resulting in chromosomal instability and increased expression of cell senescence markers. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 82-84 vimentin Mus musculus 16-24 28956310-2 2018 Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibroblasts and lens epithelial cells, resulting in chromosomal instability and increased expression of cell senescence markers. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 82-84 vimentin Mus musculus 78-81 28956310-2 2018 Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibroblasts and lens epithelial cells, resulting in chromosomal instability and increased expression of cell senescence markers. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 vimentin Mus musculus 16-24 28956310-2 2018 Mutation of the vimentin serine sites that are phosphorylated during mitosis (VIM SA/SA ) leads to cytokinetic failures in fibroblasts and lens epithelial cells, resulting in chromosomal instability and increased expression of cell senescence markers. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 vimentin Mus musculus 78-81 28956310-5 2018 Interestingly, we found a two- to fourfold increased neuronal differentiation of VIM SA/SA neurosphere cells, both in a standard 2D and in Bioactive3D cell culture systems, and determined that this effect was neurosphere cell autonomous and not dependent on cocultured astrocytes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 vimentin Mus musculus 81-84 28956310-5 2018 Interestingly, we found a two- to fourfold increased neuronal differentiation of VIM SA/SA neurosphere cells, both in a standard 2D and in Bioactive3D cell culture systems, and determined that this effect was neurosphere cell autonomous and not dependent on cocultured astrocytes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 vimentin Mus musculus 81-84 30381120-2 2018 Methods The C3d DNA was amplified using C3 cDNA as a template, and the C3d fragment was ligated with the vector plasmid pET-24a-6His-SA-IL15 after the digestion with a one-step cloning method to obtain the SA-C3d prokaryotic expression plasmid. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 133-135 endogenous retrovirus group K member 13 Homo sapiens 71-74 30381120-2 2018 Methods The C3d DNA was amplified using C3 cDNA as a template, and the C3d fragment was ligated with the vector plasmid pET-24a-6His-SA-IL15 after the digestion with a one-step cloning method to obtain the SA-C3d prokaryotic expression plasmid. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 133-135 interleukin 15 Homo sapiens 136-140 30381120-2 2018 Methods The C3d DNA was amplified using C3 cDNA as a template, and the C3d fragment was ligated with the vector plasmid pET-24a-6His-SA-IL15 after the digestion with a one-step cloning method to obtain the SA-C3d prokaryotic expression plasmid. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 133-135 endogenous retrovirus group K member 13 Homo sapiens 71-74 30002688-7 2018 Results: AngII induced an increase in SA-beta-Gal-positive cells and upregulation on expression of P21 and PAI-1 compared to the control group (p < 0.05), while apelin against this process (p < 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 38-40 angiotensinogen Homo sapiens 9-14 29677534-9 2018 Inhibition of NF-kappaB by pyrrolidine dithiocarbamate (PDTC), a selective inhibitor of NF-kappaB, partially reversed the cellular senescent phenotype induced by punicalagin in BCPAP cells as evidenced by the decreased fraction of SA-beta-Gal staining positive cells and blockage of SASP generation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 231-233 nuclear factor kappa B subunit 1 Homo sapiens 14-23 29713366-16 2018 SA and OPDA, but not JA, were higher in the PROSYS-overexpressing plants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 systemin Solanum lycopersicum 44-50 31458673-6 2018 This approach enabled us to rank tankyrase 2 inhibitor analogues, outperforming several MM-based methods, including rescoring by molecular docking and the MM-PB/SA method alone. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 161-163 tankyrase 2 Homo sapiens 33-44 29673160-9 2018 A1 overexpression or high glucose treatment increased SA &beta;-Gal activity in cultured ECs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 54-56 arginase, liver Mus musculus 0-2 29336559-3 2018 Based on the new ratio as the temperature-sensing parameter, the Sa and Sr of the BaTiO3: 0.01%Pr3+, 8%Yb3+ nanoparticles at 313 K reach as high as 0.1380 K-1 and 1.23% K-1, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 65-67 keratin 1 Homo sapiens 155-158 29336559-3 2018 Based on the new ratio as the temperature-sensing parameter, the Sa and Sr of the BaTiO3: 0.01%Pr3+, 8%Yb3+ nanoparticles at 313 K reach as high as 0.1380 K-1 and 1.23% K-1, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 65-67 keratin 1 Homo sapiens 169-172 29336559-4 2018 Similarly, the Sa and Sr of the BaTiO3: 1%Er3+, 3%Yb3+ nanoparticles at 313 K are as high as 0.0413 K-1 and 1.05% K-1, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 keratin 1 Homo sapiens 100-103 29336559-4 2018 Similarly, the Sa and Sr of the BaTiO3: 1%Er3+, 3%Yb3+ nanoparticles at 313 K are as high as 0.0413 K-1 and 1.05% K-1, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 keratin 1 Homo sapiens 114-117 28856846-8 2018 Sequence analysis revealed that the O/ME-SA/Ind-2001d isolates from Lao PDR and Vietnam were closely related to each other and similar to viruses previously circulating in India in 2013. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 interleukin 4 induced 1 Homo sapiens 68-71 28472685-2 2017 The proof of adsorption of Pb(II) ions onto NCS/SA/MC beads was identified from FT-IR and EDX-SEM Studies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-50 submaxillary gland androgen regulated protein 3B Homo sapiens 27-33 28676953-8 2018 Furthermore, AMPK activator AICAR significantly enhanced SA-beta-gal activity and antiproliferation induced by gallotannin, while AMPK inhibitor compound C did not in two HCC cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 57-59 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 13-17 29095612-7 2017 This, combined with the dependence of the electronic energy with theta, provides a methodology to extract JAB from DFT calculations that, in contrast to conventional energy differences based methods, does not require the use of ad hoc SA and SB values. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 235-237 suppressor of cytokine signaling 1 Homo sapiens 106-109 28838761-7 2017 Glutathione depletion with the glutathione synthetase inhibitor buthionine sulfoximine increased the cytotoxic effect of the photochemical treatment (PDT) most strongly in the SK-LMS-1 cells, and reduced PCIBLM-induced H2AX activation in the MES-SA cells, but not in the SK-LMS-1 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 246-248 glutathione synthetase Homo sapiens 31-53 28681467-7 2017 Vasoactive pathways such as ET-1, AT1-AA, and ROS were all reduced in RUPP+SA compared to RUPP. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 angiotensin II receptor, type 1a Rattus norvegicus 34-37 28472685-5 2017 The desorption studies reveals that the recovery of Pb(II) from NCS/SA/MC bead was found to be effective by using 0.1M HCl solution. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 68-70 submaxillary gland androgen regulated protein 3B Homo sapiens 52-58 28797844-0 2017 PD-1/PD-L1 blockade enhances the efficacy of SA-GM-CSF surface-modified tumor vaccine in prostate cancer. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 45-47 programmed cell death 1 Homo sapiens 0-4 28797844-0 2017 PD-1/PD-L1 blockade enhances the efficacy of SA-GM-CSF surface-modified tumor vaccine in prostate cancer. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 45-47 CD274 molecule Homo sapiens 5-10 28797844-0 2017 PD-1/PD-L1 blockade enhances the efficacy of SA-GM-CSF surface-modified tumor vaccine in prostate cancer. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 45-47 colony stimulating factor 2 Homo sapiens 48-54 28797844-7 2017 Taken together, PD-1/PD-L1 blockade combined with SA-GM-CSF-modified vaccine could effectively induce a strong specific antitumor immune response against prostate cancer. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 50-52 colony stimulating factor 2 Homo sapiens 53-59 27678152-7 2017 By using molecular modeling, molecular dynamics and MM-PB(GB)SA free energy estimation, we present the first computational study reporting the interaction mode of ClTx/AaCTx with MMP-2. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 61-63 matrix metallopeptidase 2 Homo sapiens 179-184 27351740-5 2017 Streptavidin-coated AgNP (SA-AgNP) facilitated distinct and specific detection of various antigens, such as CD8, CD244 and CD294 on peripheral blood leukocytes pre-incubated with respective biotinylated primary antibodies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 CD8a molecule Homo sapiens 108-111 30108713-4 2017 The inhibitory effects of the synthesized compounds against P-gp were assessed by flow cytometric determination of rhodamine 123 accumulation in P-gp over-expressing MES-SA/DX5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 170-172 ATP binding cassette subfamily B member 1 Homo sapiens 60-64 30108713-4 2017 The inhibitory effects of the synthesized compounds against P-gp were assessed by flow cytometric determination of rhodamine 123 accumulation in P-gp over-expressing MES-SA/DX5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 170-172 ATP binding cassette subfamily B member 1 Homo sapiens 145-149 28536075-9 2017 Overexpression of coilin phosphomutants increased SA-beta-gal fluorescence following treatments with cisplatin as compared to the wild type coilin transfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 50-52 coilin Homo sapiens 18-24 28548957-7 2017 Consequently, a serine 186 to alanine (SA) mutant of TTP was resistant to radiation-induced degradation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 39-41 ZFP36 ring finger protein Homo sapiens 53-56 28791835-13 2017 The IFN-gamma group increased SA-beta-gal-positive cells and reactive oxygen species (ROS) significantly after 15 days of IFN-gamma treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 interferon gamma Mus musculus 4-13 28848581-10 2017 After 2 days of treatment, free and conjugated SA levels were significantly increased in infected and mock control leaves of sweet11/sweet12 relative to all other genotypes, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 Nodulin MtN3 family protein Arabidopsis thaliana 125-132 28848581-10 2017 After 2 days of treatment, free and conjugated SA levels were significantly increased in infected and mock control leaves of sweet11/sweet12 relative to all other genotypes, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 bidirectional sugar transporter SWEET12-like protein Arabidopsis thaliana 133-140 28848581-11 2017 Induced genes in mock treated sweet11/sweet12 leaves were highly significantly enriched for several GO terms associated with SA signaling and response compared to mock treated wild-type leaves, indicating sugar-mediated priming of the SA pathway in the double mutant. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 125-127 Nodulin MtN3 family protein Arabidopsis thaliana 30-37 28848581-11 2017 Induced genes in mock treated sweet11/sweet12 leaves were highly significantly enriched for several GO terms associated with SA signaling and response compared to mock treated wild-type leaves, indicating sugar-mediated priming of the SA pathway in the double mutant. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 125-127 bidirectional sugar transporter SWEET12-like protein Arabidopsis thaliana 38-45 28848581-11 2017 Induced genes in mock treated sweet11/sweet12 leaves were highly significantly enriched for several GO terms associated with SA signaling and response compared to mock treated wild-type leaves, indicating sugar-mediated priming of the SA pathway in the double mutant. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 235-237 Nodulin MtN3 family protein Arabidopsis thaliana 30-37 28848581-11 2017 Induced genes in mock treated sweet11/sweet12 leaves were highly significantly enriched for several GO terms associated with SA signaling and response compared to mock treated wild-type leaves, indicating sugar-mediated priming of the SA pathway in the double mutant. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 235-237 bidirectional sugar transporter SWEET12-like protein Arabidopsis thaliana 38-45 28848581-12 2017 Infection assays with salicylic acid deficient sweet11/sweet12/sid2 triple mutants demonstrated that reduced susceptibility observed in sweet11/sweet12 was entirely dependent on the SA pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 182-184 Nodulin MtN3 family protein Arabidopsis thaliana 47-54 28848581-12 2017 Infection assays with salicylic acid deficient sweet11/sweet12/sid2 triple mutants demonstrated that reduced susceptibility observed in sweet11/sweet12 was entirely dependent on the SA pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 182-184 bidirectional sugar transporter SWEET12-like protein Arabidopsis thaliana 55-62 28848581-12 2017 Infection assays with salicylic acid deficient sweet11/sweet12/sid2 triple mutants demonstrated that reduced susceptibility observed in sweet11/sweet12 was entirely dependent on the SA pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 182-184 Nodulin MtN3 family protein Arabidopsis thaliana 136-143 28848581-12 2017 Infection assays with salicylic acid deficient sweet11/sweet12/sid2 triple mutants demonstrated that reduced susceptibility observed in sweet11/sweet12 was entirely dependent on the SA pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 182-184 bidirectional sugar transporter SWEET12-like protein Arabidopsis thaliana 144-151 28743869-5 2017 Since NMN-induced disease resistance was also observed in the SA-deficient sid2 mutant, an SA-independent signalling pathway also regulated the enhanced resistance induced by NMN. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 ADC synthase superfamily protein Arabidopsis thaliana 75-79 28743869-5 2017 Since NMN-induced disease resistance was also observed in the SA-deficient sid2 mutant, an SA-independent signalling pathway also regulated the enhanced resistance induced by NMN. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 ADC synthase superfamily protein Arabidopsis thaliana 75-79 28487714-0 2017 Both Light-Induced SA Accumulation and ETI Mediators Contribute to the Cell Death Regulated by BAK1 and BKK1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 19-21 BRI1-associated receptor kinase Arabidopsis thaliana 95-99 28487714-0 2017 Both Light-Induced SA Accumulation and ETI Mediators Contribute to the Cell Death Regulated by BAK1 and BKK1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 19-21 somatic embryogenesis receptor-like kinase 4 Arabidopsis thaliana 104-108 28487714-6 2017 Cell death suppressed in bak1 bkk1 by growing in dark condition recurred upon exogenously treated SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 98-100 BRI1-associated receptor kinase Arabidopsis thaliana 25-29 28487714-6 2017 Cell death suppressed in bak1 bkk1 by growing in dark condition recurred upon exogenously treated SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 98-100 somatic embryogenesis receptor-like kinase 4 Arabidopsis thaliana 30-34 28487714-7 2017 SA biosynthesis-related genes SID2 and EDS5, which encode chloroplast-localized proteins, were highly expressed in bak1-4 bkk1-1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 ADC synthase superfamily protein Arabidopsis thaliana 30-34 28487714-7 2017 SA biosynthesis-related genes SID2 and EDS5, which encode chloroplast-localized proteins, were highly expressed in bak1-4 bkk1-1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 MATE efflux family protein Arabidopsis thaliana 39-43 28487714-7 2017 SA biosynthesis-related genes SID2 and EDS5, which encode chloroplast-localized proteins, were highly expressed in bak1-4 bkk1-1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 BRI1-associated receptor kinase Arabidopsis thaliana 115-119 28487714-7 2017 SA biosynthesis-related genes SID2 and EDS5, which encode chloroplast-localized proteins, were highly expressed in bak1-4 bkk1-1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 somatic embryogenesis receptor-like kinase 4 Arabidopsis thaliana 122-126 28487714-9 2017 It suggested that overly produced SA is crucial for inducing cell death in bak1 bkk1 grown in light. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 BRI1-associated receptor kinase Arabidopsis thaliana 75-79 28487714-9 2017 It suggested that overly produced SA is crucial for inducing cell death in bak1 bkk1 grown in light. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 somatic embryogenesis receptor-like kinase 4 Arabidopsis thaliana 80-84 28487714-12 2017 In this study, we revealed that light-triggered SA accumulation plays major role in inducing the cell death in bak1 bkk1, mediated by ETI components. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-50 BRI1-associated receptor kinase Arabidopsis thaliana 111-115 28487714-12 2017 In this study, we revealed that light-triggered SA accumulation plays major role in inducing the cell death in bak1 bkk1, mediated by ETI components. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-50 somatic embryogenesis receptor-like kinase 4 Arabidopsis thaliana 116-120 28155114-1 2017 KEY MESSAGE: Over-expression of SlJA2 decreased the accumulation of SA, which resulted in significant physiological and gene expression changes in transgenic tobacco plants, leading to the decreased heat tolerance of transgenic tobacco. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 7-9 jasmonic acid 2 Solanum lycopersicum 32-37 28134375-4 2017 The red-NIR fluorescence probe TG-SA can be effectively used for staining HSA/SA in gel electrophoresis, quantification and validation of HSA in clinical urine samples and monitoring serum albumin in live cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 albumin Homo sapiens 183-196 28134375-4 2017 The red-NIR fluorescence probe TG-SA can be effectively used for staining HSA/SA in gel electrophoresis, quantification and validation of HSA in clinical urine samples and monitoring serum albumin in live cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 albumin Homo sapiens 183-196 27351740-5 2017 Streptavidin-coated AgNP (SA-AgNP) facilitated distinct and specific detection of various antigens, such as CD8, CD244 and CD294 on peripheral blood leukocytes pre-incubated with respective biotinylated primary antibodies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 CD244 molecule Homo sapiens 113-118 27351740-5 2017 Streptavidin-coated AgNP (SA-AgNP) facilitated distinct and specific detection of various antigens, such as CD8, CD244 and CD294 on peripheral blood leukocytes pre-incubated with respective biotinylated primary antibodies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 prostaglandin D2 receptor 2 Homo sapiens 123-128 27812882-2 2017 In Drosophila imaginal epithelia, clones of cells expressing oncogenic Ras (RasV12) show several markers of cellular senescence, such as elevation of SA-beta-gal activity, upregulation of the Cdk inhibitor Dacapo (Dap), and heterochromatinization. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 150-152 Ras oncogene at 85D Drosophila melanogaster 71-74 27812882-2 2017 In Drosophila imaginal epithelia, clones of cells expressing oncogenic Ras (RasV12) show several markers of cellular senescence, such as elevation of SA-beta-gal activity, upregulation of the Cdk inhibitor Dacapo (Dap), and heterochromatinization. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 150-152 Ras oncogene at 85D Drosophila melanogaster 76-82 27864509-6 2016 PKA expression was increased, and PKA sites Ser2808 in ryanodine receptor type-2, Ser16 in phospholamban, and Ser23/24 in troponin-I were hyperphosphorylated in SA mice, whereas phosphorylation of substrates for calcium/calmodulin-dependent protein kinase II was unchanged. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 161-163 ryanodine receptor 2, cardiac Mus musculus 55-80 27636505-8 2016 Agreement with official CoD registry was 94.6% (kappa=0.88) in the SA and 95.4% (kappa=0.91) in the CA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 67-69 small nuclear ribonucleoprotein polypeptides B and B1 Homo sapiens 24-27 26672612-4 2016 Increased SA-beta-gal activity and the upregulation of ACE and AT1R in senescent cells were prevented by antioxidants, an ACE inhibitor, and by an AT1 receptor blocker. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 angiotensin I converting enzyme Homo sapiens 122-125 32480529-10 2016 These results indicate that the SlBAH1-dependent activation of defence-related genes played a key role in the enhanced fungal resistance observed in the SlBAH1-silenced plants and may be related to the SA-dependent and JA-dependent signalling pathways. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 202-204 probable E3 ubiquitin-protein ligase BAH1-like 1 Solanum lycopersicum 32-38 32480529-10 2016 These results indicate that the SlBAH1-dependent activation of defence-related genes played a key role in the enhanced fungal resistance observed in the SlBAH1-silenced plants and may be related to the SA-dependent and JA-dependent signalling pathways. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 202-204 probable E3 ubiquitin-protein ligase BAH1-like 1 Solanum lycopersicum 153-159 27799936-7 2016 The transcript expression of SA biosynthetic gene ICS1 and antioxidative enzymes (CAT and SOD) showed upregulation during stress. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 29-31 isochorismate synthase, chloroplastic-like Nicotiana tabacum 50-54 27553048-3 2016 METHODS: An in vitro laboratory setup was used to model the cerebrospinal fluid (CSF) drainage conditions similar to a ventriculo-peritoneal shunt and to test the SA (resistance of +20 cmH2O in 90 ) and proSA (adjustable resistance of 0 to +40 cmH2O in 90 ). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 163-165 troponin T2, cardiac type Homo sapiens 185-189 27314515-8 2016 Also, the relative expression of these genes involved in salicylic acid/jasmonic acid (SA/JA) signaling pathways was analyzed at different stages after aphid-inoculation and the results demonstrated that there was significantly higher expression of JA-induced LOX gene in both transgenic and wild-type plants inoculated by aphid than the non-inoculated ones while no significant difference in the expression of SA-induced PR-1a gene among them was found, which indicated the JA-mediated resistance response was activated during aphid infestation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 87-89 probable linoleate 9S-lipoxygenase 5 Nicotiana tabacum 260-263 27314515-8 2016 Also, the relative expression of these genes involved in salicylic acid/jasmonic acid (SA/JA) signaling pathways was analyzed at different stages after aphid-inoculation and the results demonstrated that there was significantly higher expression of JA-induced LOX gene in both transgenic and wild-type plants inoculated by aphid than the non-inoculated ones while no significant difference in the expression of SA-induced PR-1a gene among them was found, which indicated the JA-mediated resistance response was activated during aphid infestation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 411-413 probable linoleate 9S-lipoxygenase 5 Nicotiana tabacum 260-263 27994710-4 2016 Both increased SA-beta-Gal activity and ROS release were mediated by TGF-beta1, the concentration of which in varicose serum was elevated and the activity of which in vitro was prevented using specific neutralizing antibody. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 transforming growth factor beta 1 Homo sapiens 69-78 27209521-3 2016 Here, we conducted a set of hydroponic assays with another SA-deficient mutant sid2 to examine the endogenous roles of SA in Cd tolerance, especially focusing on the glutathione (GSH) cycling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 59-61 ADC synthase superfamily protein Arabidopsis thaliana 79-83 27425415-7 2016 The level of NPY was significantly increased in AA group at 30 minutes and 2 hours compared to baseline and SA group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 108-110 neuropeptide Y Homo sapiens 13-16 29235339-4 2016 We have shown previously that calmodulin antagonists reduced the level of mitochondrial membrane polarization and induced increase of the ionized Sa concentration in both the mitochondrial matrix and cell cytoplasm. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 146-148 calmodulin 1 Homo sapiens 30-40 27362652-9 2016 Overexpression of miR-34a, miR-34b, or miR-34c in lung epithelial cells was associated with higher SA-betagal activity (27.8%, 35.1%, and 38.2%, respectively) relative to control treated cells (8.8%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 microRNA 34a Homo sapiens 18-25 27362652-9 2016 Overexpression of miR-34a, miR-34b, or miR-34c in lung epithelial cells was associated with higher SA-betagal activity (27.8%, 35.1%, and 38.2%, respectively) relative to control treated cells (8.8%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 microRNA 34b Homo sapiens 27-34 27362652-9 2016 Overexpression of miR-34a, miR-34b, or miR-34c in lung epithelial cells was associated with higher SA-betagal activity (27.8%, 35.1%, and 38.2%, respectively) relative to control treated cells (8.8%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 microRNA 34c Homo sapiens 39-46 26850364-7 2016 Using inhibitory analysis and selective antagonists, we now show that Ang II initiates periodic Sa(2+)-oscillations and transient responses by activating AT1 and AT2 receptors and involving branched signaling cascades: 1) Ang II Gq PLC IP3 IP3Rs Ca(2+) 2) Gbetagamma PI3Kgamma PKB 3) PKB eNOS NO PKG 4) CD38 cADPR RyRs Ca(2+) In these cascades, AT1 receptors play the leading role. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 96-98 angiotensinogen Homo sapiens 70-76 26909594-5 2016 Conversely, upregulation of GDF15-induced cellular senescence in HAECs, confirmed by G0/G1 cell cycle arrest, decreased during cell proliferation and increased SA-beta-gal staining. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 160-162 growth differentiation factor 15 Homo sapiens 28-33 26885980-7 2016 Treatment with both TRF and ATF was beneficial to senescent myoblasts in reclaiming the morphology of young cells, improved cell viability and decreased SA-beta-gal expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 153-155 glial cell derived neurotrophic factor Homo sapiens 28-31 29856587-11 2016 The in vivo antitumor efficacies of SA-modified Pix liposomes showed that the tumor inhibition effects were Pix-S18L(97.4% +- 2.1%) > Pix-S14L(73.1% +-21.1%) > Pix-S12L(53.9% +- 17.8%) > Pix-S16L(32.9%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 Rho guanine nucleotide exchange factor (GEF7) Mus musculus 48-51 29856587-11 2016 The in vivo antitumor efficacies of SA-modified Pix liposomes showed that the tumor inhibition effects were Pix-S18L(97.4% +- 2.1%) > Pix-S14L(73.1% +-21.1%) > Pix-S12L(53.9% +- 17.8%) > Pix-S16L(32.9%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 Rho guanine nucleotide exchange factor (GEF7) Mus musculus 108-111 29856587-11 2016 The in vivo antitumor efficacies of SA-modified Pix liposomes showed that the tumor inhibition effects were Pix-S18L(97.4% +- 2.1%) > Pix-S14L(73.1% +-21.1%) > Pix-S12L(53.9% +- 17.8%) > Pix-S16L(32.9%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 Rho guanine nucleotide exchange factor (GEF7) Mus musculus 108-111 29856587-11 2016 The in vivo antitumor efficacies of SA-modified Pix liposomes showed that the tumor inhibition effects were Pix-S18L(97.4% +- 2.1%) > Pix-S14L(73.1% +-21.1%) > Pix-S12L(53.9% +- 17.8%) > Pix-S16L(32.9%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 Rho guanine nucleotide exchange factor (GEF7) Mus musculus 108-111 29856587-11 2016 The in vivo antitumor efficacies of SA-modified Pix liposomes showed that the tumor inhibition effects were Pix-S18L(97.4% +- 2.1%) > Pix-S14L(73.1% +-21.1%) > Pix-S12L(53.9% +- 17.8%) > Pix-S16L(32.9%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 Rho guanine nucleotide exchange factor (GEF7) Mus musculus 108-111 26808317-8 2016 SA had lower SBP than EU(-4.57 mmHg, 95% CI -6.20 to -2.93; -2.97 mmHg, 95% CI -5.45 to -0.49) but similar DBP values. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 selenium binding protein 1 Homo sapiens 13-16 27307500-3 2016 In initial experiments, 10 mg/kg SA-57 fully substituted for CP55,940 ((-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol), a high-efficacy CB1 receptor agonist in C57BL/6J mice and for AEA in FAAH (-/-) mice. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 cannabinoid receptor 1 (brain) Mus musculus 178-181 27307500-3 2016 In initial experiments, 10 mg/kg SA-57 fully substituted for CP55,940 ((-)-cis-3-[2-hydroxy-4-(1,1-dimethylheptyl)phenyl]-trans-4-(3-hydroxypropyl)cyclohexanol), a high-efficacy CB1 receptor agonist in C57BL/6J mice and for AEA in FAAH (-/-) mice. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 fatty acid amide hydrolase Mus musculus 231-235 27307500-7 2016 In addition, the CB1 receptor antagonist rimonabant blocked the generalization of SA-57, as well as substitution of CP55,940, JZL195, MJN110, and JZL184. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 82-84 cannabinoid receptor 1 (brain) Mus musculus 17-20 26573928-4 2016 Growth hormone (GH) producing adenomas showed the strongest SA-beta-GAL, with densely granulated (DG)-GH adenomas more reactive than the sparsely granulated (SG). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 60-62 growth hormone 1 Homo sapiens 0-14 26573928-4 2016 Growth hormone (GH) producing adenomas showed the strongest SA-beta-GAL, with densely granulated (DG)-GH adenomas more reactive than the sparsely granulated (SG). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 60-62 growth hormone 1 Homo sapiens 16-18 26941721-12 2016 The results indicate that bacterial VOCs potentiate expression of PR1 and PDF1.2 but not ChiB, which stimulates SA- and JA-dependent signaling pathways in plant ISR and protects plants against pathogen colonization. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 112-114 pathogenesis-related protein 1 Arabidopsis thaliana 66-69 26941721-12 2016 The results indicate that bacterial VOCs potentiate expression of PR1 and PDF1.2 but not ChiB, which stimulates SA- and JA-dependent signaling pathways in plant ISR and protects plants against pathogen colonization. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 112-114 protodermal factor 1 Arabidopsis thaliana 74-78 26254613-7 2016 Positive TTF-1 and Napsin A expression was more common in SA, while they were both negative in IMA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 58-60 NK2 homeobox 1 Homo sapiens 9-14 26254613-7 2016 Positive TTF-1 and Napsin A expression was more common in SA, while they were both negative in IMA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 58-60 napsin A aspartic peptidase Homo sapiens 19-27 32263131-2 2015 SA-betaGal possesses the beta-galactopyranoside group to react with beta-galactosidase and releases the fluorescent salicylaldehyde azine with both aggregation induced emission (AIE) and excited-state intramolecular proton transfer (ESIPT) characteristics. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 galactosidase beta 1 Homo sapiens 68-86 26216888-10 2015 Production of the proinflammatory cytokine IFN-gamma, but not TNF-alpha or perforin, was essential to IL-15 SA-induced immunotoxicity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 108-110 interferon gamma Homo sapiens 43-52 26433201-9 2016 The target genes of the two transcription factors and epistasis analysis suggested that WRKY11 regulated AR156-triggered ISR through activating the JA signalling pathway, and WRKY70 regulated the ISR through activating the SA signalling pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 223-225 WRKY DNA-binding protein 11 Arabidopsis thaliana 88-94 26433201-9 2016 The target genes of the two transcription factors and epistasis analysis suggested that WRKY11 regulated AR156-triggered ISR through activating the JA signalling pathway, and WRKY70 regulated the ISR through activating the SA signalling pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 223-225 WRKY DNA-binding protein 70 Arabidopsis thaliana 175-181 26635826-5 2015 By contrast, ABA treatment to flc plants leads to a reduction of JA and SA contents. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 molybdenum cofactor sulfurase Solanum lycopersicum 30-33 26515041-2 2015 The results revealed that the compounds SA-1 to SA-9, SB-2, SB-3, SB-4, SB-7 and SC-2 showed a good range of IC50 values against THP-1, COLO-205, HCT-116 and PC-3 cell lines, while the other four cell lines among these were found to be almost resistant. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 GLI family zinc finger 2 Homo sapiens 129-134 26393439-8 2015 In an acute myocardial infarction model, Girdin(SA/SA) suppressed the accumulation and proliferation of cardiac myofibroblasts in the infarcted area. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-50 coiled coil domain containing 88A Mus musculus 41-47 26393439-8 2015 In an acute myocardial infarction model, Girdin(SA/SA) suppressed the accumulation and proliferation of cardiac myofibroblasts in the infarcted area. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 51-53 coiled coil domain containing 88A Mus musculus 41-47 27250680-8 2015 We conclude that CAF-1-mediated chromatin assembly prevents the establishment of a primed state that may under standard non-sterile growth conditions result in spurious activation of SA-dependent defence responses and consequential reduction of plant vigour. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 183-185 chromatin assembly factor 1 subunit A Homo sapiens 17-22 26105052-6 2015 In this study, we found that SAs on gB are essential for the association with MAG as well as for membrane fusion during VZV infection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 29-32 myelin associated glycoprotein Homo sapiens 78-81 26244551-9 2015 The upregulation of PGC-1alpha increased the levels of mRNA for antioxidant enzymes and stimulated mitochondrial biogenesis, decreased ROS levels, and reduced SA-beta-gal staining in H2O2-treated ARPE-19 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 159-161 PPARG coactivator 1 alpha Homo sapiens 20-30 25950931-2 2015 The streptavidin functionalized zirconium-porphyrin MOF (PCN-222@SA) was prepared as signal nanoprobe via covalent method and demonstrated high electrocatalysis for O2 reduction. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 65-67 lysine acetyltransferase 8 Homo sapiens 52-55 25863981-8 2015 Expression of RAR-related orphan receptor A (RORA), which has been linked to asthma in genome-wide association studies, was significantly upregulated in patients with SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 167-169 RAR related orphan receptor A Homo sapiens 14-43 25863981-8 2015 Expression of RAR-related orphan receptor A (RORA), which has been linked to asthma in genome-wide association studies, was significantly upregulated in patients with SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 167-169 RAR related orphan receptor A Homo sapiens 45-49 25863981-9 2015 Gene network modeling revealed decreased glucocorticoid receptor signaling and increased activity of the mitogen-activated protein kinase and Jun kinase cascades in patients with SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 179-181 mitogen-activated protein kinase 9 Homo sapiens 142-152 24788960-7 2015 With SA-beta-Gal staining, we show that Klf4(-/-) MEFs enter senescence earlier than Klf4(+/+) MEFs, and western blot shows accumulation of p21 and p53 with increasing passages. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 5-7 Kruppel-like factor 4 (gut) Mus musculus 40-44 26216888-10 2015 Production of the proinflammatory cytokine IFN-gamma, but not TNF-alpha or perforin, was essential to IL-15 SA-induced immunotoxicity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 108-110 interleukin 15 Homo sapiens 102-107 26155672-9 2015 PLC expression was found to be up-regulated by SA and down-regulated by wound in leaf tissues; however, there was no significant difference in the expression of PLC in plants subjected to high temperature and H2O2. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 phosphoinositide phospholipase C 2-like Vigna radiata 0-3 25766579-5 2015 In this study, the abilities for specific detection of CEA expressed by tumor cells with anti-CEA sdAbs biotinylated in vitro and in vivo, as well as with anti-CEA mAbs biotinylated in vitro, were compared using flow cytometry and the conjugates of streptavidin with QDs (SA-QDs). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 272-274 CEA cell adhesion molecule 3 Homo sapiens 55-58 25766579-7 2015 The data also show that simultaneous use of biotinylated sdAbs with highly fluorescent SA-QDs can considerably improve the sensitivity of detection of CEA on tumor cell surfaces. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 87-89 CEA cell adhesion molecule 3 Homo sapiens 151-154 25596698-7 2015 Of note, PGRMC1 overexpression led to the epithelial-mesenchymal transition (EMT) of the sensitive MES-SA cells, thus facilitating their migration and invasion. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 103-105 progesterone receptor membrane component 1 Homo sapiens 9-15 25842137-4 2015 In this paper, we report HAp nanorod crystal synthesized successfully by a biomimetic method using calcium chloride and ammonium dihydrogen phosphate as reagents in the presence of silk fibroin/sodium alginate (SF/SA) fibrous hydrogels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 214-216 reticulon 3 Homo sapiens 25-28 25847236-5 2015 Here, we analyze the ability to repair wounds in the skin of phosphovimentin-deficient (VIM(SA/SA)) mice. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 92-94 vimentin Mus musculus 88-91 25847236-7 2015 Accordingly, the mRNA level of p21 (a p53-responsive gene) was elevated in a VIM(SA/SA)-specific manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 31-34 25847236-7 2015 Accordingly, the mRNA level of p21 (a p53-responsive gene) was elevated in a VIM(SA/SA)-specific manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 transformation related protein 53, pseudogene Mus musculus 38-41 25847236-7 2015 Accordingly, the mRNA level of p21 (a p53-responsive gene) was elevated in a VIM(SA/SA)-specific manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 vimentin Mus musculus 77-80 25847236-7 2015 Accordingly, the mRNA level of p21 (a p53-responsive gene) was elevated in a VIM(SA/SA)-specific manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 84-86 cyclin-dependent kinase inhibitor 1A (P21) Mus musculus 31-34 25847236-7 2015 Accordingly, the mRNA level of p21 (a p53-responsive gene) was elevated in a VIM(SA/SA)-specific manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 84-86 transformation related protein 53, pseudogene Mus musculus 38-41 25847236-7 2015 Accordingly, the mRNA level of p21 (a p53-responsive gene) was elevated in a VIM(SA/SA)-specific manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 84-86 vimentin Mus musculus 77-80 25978330-9 2015 In addition, SA and SB also prevented UVB-induced cell apoptosis and the cleavage of caspase-3, caspase-8 and caspase-9. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 caspase 3 Homo sapiens 85-94 25978330-9 2015 In addition, SA and SB also prevented UVB-induced cell apoptosis and the cleavage of caspase-3, caspase-8 and caspase-9. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 caspase 8 Homo sapiens 96-105 25978330-9 2015 In addition, SA and SB also prevented UVB-induced cell apoptosis and the cleavage of caspase-3, caspase-8 and caspase-9. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 caspase 9 Homo sapiens 110-119 26122223-0 2015 ANTIPSYCHOTICS REVERSE P-GLYCOPROTEIN-MEDIATED DOXORUBICIN RESISTANCE IN HUMAN UTERINE SARCOMA MES-SA/Dx5 CELLS: A NOVEL APPROACH TO CANCER CHEMOTHERAPY. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 87-89 ATP binding cassette subfamily B member 1 Homo sapiens 47-69 25879533-10 2015 The small interfering RNA of p22phox undermined the increase in SA-beta-gal activity induced by intermittent high glucose. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 cytochrome b-245 alpha chain Homo sapiens 29-36 25616502-15 2015 In the pleurisy model, induced by carrageenan, treatment with SA inhibited important events involved in inflammatory responses, namely leukocyte influx, plasma leakage, and increased inflammatory mediators (TNF-alpha, IL-1beta, and chemokine CXCL1), in the pleural exudate. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 tumor necrosis factor Mus musculus 207-216 25616502-15 2015 In the pleurisy model, induced by carrageenan, treatment with SA inhibited important events involved in inflammatory responses, namely leukocyte influx, plasma leakage, and increased inflammatory mediators (TNF-alpha, IL-1beta, and chemokine CXCL1), in the pleural exudate. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 interleukin 1 beta Mus musculus 218-226 25616502-15 2015 In the pleurisy model, induced by carrageenan, treatment with SA inhibited important events involved in inflammatory responses, namely leukocyte influx, plasma leakage, and increased inflammatory mediators (TNF-alpha, IL-1beta, and chemokine CXCL1), in the pleural exudate. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 chemokine (C-X-C motif) ligand 1 Mus musculus 242-247 25552290-4 2015 SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 linoleate 9S-lipoxygenase-4 Glycine max 15-27 26084179-5 2015 RESULT: Compared with the senescence group, the Rg1 anti-senescence group and the Rg1-treated group showed lower percentage in SA-beta-Gal-stained positive cells, decreased cell proportion in G1 phase, increased number of CFU-Mix, up-regulated in SIRT6 mRNA and protein expression, down-regulation in NF-KB mRNA and protein expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 127-129 protein phosphatase 1 regulatory subunit 3A Homo sapiens 48-51 26084179-5 2015 RESULT: Compared with the senescence group, the Rg1 anti-senescence group and the Rg1-treated group showed lower percentage in SA-beta-Gal-stained positive cells, decreased cell proportion in G1 phase, increased number of CFU-Mix, up-regulated in SIRT6 mRNA and protein expression, down-regulation in NF-KB mRNA and protein expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 127-129 protein phosphatase 1 regulatory subunit 3A Homo sapiens 82-85 25552290-4 2015 SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 linoleate 9S-lipoxygenase-4 Glycine max 29-32 25552290-4 2015 SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 9-divinyl ether synthase-like Glycine max 38-57 25552290-4 2015 SA reduces the lipoxygenase (LOX) and hydroperoxide lyase (HPL) activity, which in turn resulted in reduction in the TBA number and carbonyl value in contrast to MJ. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 9-divinyl ether synthase-like Glycine max 59-62 25408353-1 2015 glycosyltransferase (GSL: GLTs) genes involved in SA-LeX and related GSLs biosynthesis in carcinoma cells by Biosimilar apoptotic agents: potential anticancer drugs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 50-52 cathepsin A Homo sapiens 21-24 25657597-7 2015 The risk of SA was also increased in pregnancies where the mother had ADHD but did not use MPH/ATX (aRR 1.56, 95% CI 1.11-2.20). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 12-14 arrestin beta 1 Homo sapiens 100-105 25488711-1 2015 AIM: To evaluate the prevalence and diagnostic significance of the autoantibody against citrullinated vimentin (anti-Sa) compared with the widely used anti-cyclic citrullinated peptide autoantibody (anti-CCP) in patients with rheumatoid arthritis (RA). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 117-119 vimentin Homo sapiens 102-110 24838830-6 2014 The chirodiastaltic energies amount to a total of 1.77 kJ mol(-1) for the Ra:Ra versus Ra:Sa (PH2-PH2 )2 dimers, 0.81 kJ mol(-1) for the RSa:RSa versus RSa:SRa (PH2-PHF)2 dimers, and 2.93 kJ mol(-1) for the RRa:RRa versus RRa:SSa (PH2-PHF)2 dimers. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 90-92 steroid receptor RNA activator 1 Homo sapiens 156-159 25897470-6 2015 In addition, the marker genes for the SA-mediated signaling pathways, PR-1, is promptly expressed with elicitor application. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 38-40 pathogenesis-related protein 1 Arabidopsis thaliana 70-74 25532105-11 2014 In addition, in rats that received the olfactogustatory cue and 500 ppm CS2 during SA, a social environment where the nicotine-associated olfactory cue is present, induced much stronger drug-seeking behavior compared to a social environment lacking the olfactogustatory cue. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 83-85 calsyntenin 2 Rattus norvegicus 72-75 25924578-5 2015 In both patients and controls, BAFF expression was significantly upregulated following LTA-SA and beta-1,3-glucan exposure (toll-like receptor-2 ligands), but not following LPS stimulation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 TNF superfamily member 13b Homo sapiens 31-35 24430726-8 2015 For SLA TI, the Sa results for TI_G1 and TI_G2 were 1.99 +- 0.5 and 3.37 +- 0.75 mum(2), respectively, and the Ra results were 1.78 +- 0.53 and 3.84 +- 0.63 mum, respectively (both p < .05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 16-18 retinoic acid receptor responder 1 Homo sapiens 31-36 24430726-8 2015 For SLA TI, the Sa results for TI_G1 and TI_G2 were 1.99 +- 0.5 and 3.37 +- 0.75 mum(2), respectively, and the Ra results were 1.78 +- 0.53 and 3.84 +- 0.63 mum, respectively (both p < .05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 16-18 retinoic acid receptor responder 2 Homo sapiens 41-46 25401518-5 2014 However, expression of Wnt target genes and CRE activities was downregulated in Wnt5A shRNA stably-transfected MES-SA/Dx5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 115-117 Wnt family member 5A Homo sapiens 23-26 25401518-5 2014 However, expression of Wnt target genes and CRE activities was downregulated in Wnt5A shRNA stably-transfected MES-SA/Dx5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 115-117 Wnt family member 5A Homo sapiens 80-85 25255196-3 2014 Here, we achieved selective delivery of recombinant human erythropoietin (rHuEPO) to bone marrow, via its encapsulation in liposomes with l-glutamic acid, N-(3-carboxy-1-oxopropyl)-, 1,5-dihexadecyl ester (SA) (liposome-EPO). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 206-208 erythropoietin Homo sapiens 58-72 25255196-5 2014 Also, we determined that liposome-EPO delivery to bone marrow depended on specific uptake by bone marrow macrophages because of the presence of SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 144-146 erythropoietin Homo sapiens 34-37 25087910-11 2014 The percentage of SA-beta-Gal-positive cells induced by H2 O2 treatment was decreased by glucosamine, accompanied by the decline of p70S6K phosphorylation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 ribosomal protein S6 kinase B1 Rattus norvegicus 132-138 25179857-3 2014 In the current study, we raised the rigorous quantum mechanics/molecular mechanics in combination with semi-empirical Poisson-Boltzmann/surface area (QM/MM-PB/SA) as an efficient strategy to characterize the intermolecular interaction between Akt kinase and its small-molecule ligands, although this hybrid approach is computationally expensive as compared to those empirical methods. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 159-161 AKT serine/threonine kinase 1 Homo sapiens 243-246 25179857-4 2014 In a round of experimental activity reproduction test based on a set of known Akt-inhibitor complexes, QM/MM-PB/SA has been shown to perform much better than two widely used scoring functions as well as the sophisticated MM-PB/SA analysis with or without improvement by molecular dynamics (MD) simulations. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 112-114 AKT serine/threonine kinase 1 Homo sapiens 78-81 25179857-4 2014 In a round of experimental activity reproduction test based on a set of known Akt-inhibitor complexes, QM/MM-PB/SA has been shown to perform much better than two widely used scoring functions as well as the sophisticated MM-PB/SA analysis with or without improvement by molecular dynamics (MD) simulations. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 227-229 AKT serine/threonine kinase 1 Homo sapiens 78-81 25179857-5 2014 Next, the QM/MM-PB/SA was employed to screen for strong Akt binders from an apigenin analogue set. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 19-21 AKT serine/threonine kinase 1 Homo sapiens 56-59 25045812-9 2014 Finally, a single vaccination with rF1-V adjuvanted with SA-4-1BBL+alum had better protective efficacy than vaccines containing individual adjuvants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 57-59 Renal disease susceptibility QTL 1 Rattus norvegicus 35-38 24850148-4 2014 Citrullinated vimentin is the target of anti-Sa antibodies, which are specific to rheumatoid arthritis, and play a critical role in the pathogenesis of the disease. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 45-47 vimentin Homo sapiens 14-22 24814288-11 2014 Taken together, our data demonstrate that FZD1 regulates PKCdelta, and the PKCdelta/AP-1 signalling transduction pathway plays an important role in drug resistance in MES-SA/Dx5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 171-173 frizzled class receptor 1 Homo sapiens 42-46 24814288-11 2014 Taken together, our data demonstrate that FZD1 regulates PKCdelta, and the PKCdelta/AP-1 signalling transduction pathway plays an important role in drug resistance in MES-SA/Dx5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 171-173 protein kinase C delta Homo sapiens 75-83 25410603-1 2014 Hearts of mice with reduction of function mutation in STAT3 (SA/SA) develop fibrotic collagen foci and reduced systolic function with hypertension. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 61-63 signal transducer and activator of transcription 3 Mus musculus 54-59 25410603-1 2014 Hearts of mice with reduction of function mutation in STAT3 (SA/SA) develop fibrotic collagen foci and reduced systolic function with hypertension. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 signal transducer and activator of transcription 3 Mus musculus 54-59 24977649-6 2014 By combining a physics-based scoring function with a knowledge-based structural filter, we improve the predictability and validate the practical use of MD-PB/SA in lead discovery by identifying novel inhibitors of p38 MAP kinase. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 158-160 mitogen-activated protein kinase 14 Homo sapiens 214-217 24786398-9 2014 Compared with control animals, CD28-SA-treated mice showed increased collagen de novo expression within the scar, correlating with decreased rates of left ventricular ruptures. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 CD28 antigen Mus musculus 31-35 24612849-4 2014 In this article, we report that At4g13040 (referred herein as Apetala 2 family protein involved in SA mediated disease defense 1 - APD1) is an important regulator for SA mediated plant defense. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 32-41 24612849-4 2014 In this article, we report that At4g13040 (referred herein as Apetala 2 family protein involved in SA mediated disease defense 1 - APD1) is an important regulator for SA mediated plant defense. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 Integrase-type DNA-binding superfamily protein Arabidopsis thaliana 62-71 24612849-4 2014 In this article, we report that At4g13040 (referred herein as Apetala 2 family protein involved in SA mediated disease defense 1 - APD1) is an important regulator for SA mediated plant defense. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 RING/U-box superfamily protein Arabidopsis thaliana 131-135 24612849-5 2014 The APD1 gene is upregulated upon pathogen inoculation, exogenous SA application and in the mutant that constitutively activates SA signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 66-68 RING/U-box superfamily protein Arabidopsis thaliana 4-8 24612849-5 2014 The APD1 gene is upregulated upon pathogen inoculation, exogenous SA application and in the mutant that constitutively activates SA signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 129-131 RING/U-box superfamily protein Arabidopsis thaliana 4-8 24612849-7 2014 Our results suggest that APD1 functions downstream of PAD4 in Arabidopsis and promotes pathogen-induced SA accumulation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 104-106 RING/U-box superfamily protein Arabidopsis thaliana 25-29 24612849-7 2014 Our results suggest that APD1 functions downstream of PAD4 in Arabidopsis and promotes pathogen-induced SA accumulation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 104-106 alpha/beta-Hydrolases superfamily protein Arabidopsis thaliana 54-58 24612849-8 2014 Exogenous SA application completely restores the loss-of-resistance phenotype of the apd1 mutant. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 RING/U-box superfamily protein Arabidopsis thaliana 85-89 24612849-9 2014 Thus, APD1 is a positive regulator of disease defense that functions upstream of SA accumulation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 RING/U-box superfamily protein Arabidopsis thaliana 6-10 24919709-1 2014 BACKGROUND: The nonexpressor of pathogenesis-related genes 1, NPR1 (also known as NIM1 and SAI1), is a key regulator of SA-mediated systemic acquired resistance (SAR) in Arabidopsis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 regulatory protein (NPR1) Arabidopsis thaliana 62-66 25063119-4 2014 Gene expressions of focal adhesion kinase, integrin-alpha6beta4, and laminin-5 (alpha3, beta3, gamma2) were significantly higher on SA-treated c.p.Ti than on c.p.Ti or AO c.p.Ti after 7 days (P<0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 132-134 eukaryotic translation elongation factor 1 beta 2 pseudogene 2 Homo sapiens 88-93 25063119-4 2014 Gene expressions of focal adhesion kinase, integrin-alpha6beta4, and laminin-5 (alpha3, beta3, gamma2) were significantly higher on SA-treated c.p.Ti than on c.p.Ti or AO c.p.Ti after 7 days (P<0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 132-134 tryptophanyl-tRNA synthetase 1 Homo sapiens 95-101 24820128-4 2014 Here, the expression stability of members of the soybean EF1alpha gene family (named EF1alpha 1a1, 1a2, 1b, 2a, 2b and 3) was evaluated in different tissues during plant development and stress exposure (SA and PEG). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 203-205 elongation factor 1-alpha Glycine max 57-65 24820128-4 2014 Here, the expression stability of members of the soybean EF1alpha gene family (named EF1alpha 1a1, 1a2, 1b, 2a, 2b and 3) was evaluated in different tissues during plant development and stress exposure (SA and PEG). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 203-205 elongation factor 1-alpha Glycine max 85-93 24820128-8 2014 Under stress conditions, no suitable combination including only EF1alpha genes was found; however, some genes were relatively stable in leaves (EF1alpha 1a2) and roots (EF1alpha 1a1) treated with SA as well as in roots treated with PEG (EF1alpha 2b). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 196-198 elongation factor 1-alpha Glycine max 144-152 24820128-8 2014 Under stress conditions, no suitable combination including only EF1alpha genes was found; however, some genes were relatively stable in leaves (EF1alpha 1a2) and roots (EF1alpha 1a1) treated with SA as well as in roots treated with PEG (EF1alpha 2b). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 196-198 elongation factor 1-alpha Glycine max 144-152 24820128-8 2014 Under stress conditions, no suitable combination including only EF1alpha genes was found; however, some genes were relatively stable in leaves (EF1alpha 1a2) and roots (EF1alpha 1a1) treated with SA as well as in roots treated with PEG (EF1alpha 2b). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 196-198 elongation factor 1-alpha Glycine max 144-152 24814288-5 2014 In this work, the PKCdelta inhibitor Rottlerin was found to reduce ABCB1 expression and to inhibit the MDR drug pumping ability in the MES-SA/Dx5 cells when compared with the doxorubicin-sensitive parental cell line, MES-SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 139-141 protein kinase C delta Homo sapiens 18-26 24969594-5 2014 ALP expression and activity showed a significant decrease at the 8th passage after inhibition (35.36 +- 2.55) U/g, compared with the negative control group[(49.76 +- 4.30) U/g] (t = 4.989, P = 0.008).SA-beta-Gal-positive cells could be seen as early as the 8th passage and more positive cells were evident at the 10th passage. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 200-202 alkaline phosphatase, placental Homo sapiens 0-3 24618889-7 2014 Apoptosis resistance was caused by reduced expression of caspase-8 and DR 4/TRAIL-R1 in ESS-1 and MES-SA cells, respectively, due to epigenetic silencing by DNA hypermethylation of gene promoter sequences. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 102-104 caspase 8 Homo sapiens 57-66 24618889-7 2014 Apoptosis resistance was caused by reduced expression of caspase-8 and DR 4/TRAIL-R1 in ESS-1 and MES-SA cells, respectively, due to epigenetic silencing by DNA hypermethylation of gene promoter sequences. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 102-104 TNF receptor superfamily member 10a Homo sapiens 71-75 24618889-7 2014 Apoptosis resistance was caused by reduced expression of caspase-8 and DR 4/TRAIL-R1 in ESS-1 and MES-SA cells, respectively, due to epigenetic silencing by DNA hypermethylation of gene promoter sequences. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 102-104 TNF receptor superfamily member 10a Homo sapiens 76-84 24210883-10 2014 Fluorescently labeled IVIg or SA-IVIg bound DCs and colocalized specifically to the C-type lectin DCIR. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 C-type lectin domain family 4, member a2 Mus musculus 98-102 24239835-3 2014 Such membrane-modulating properties attributed to the unimer form of copolymers increase in the order Pluronic L61<<TBC<TBC-SA and correlate with an ability of TBCs to promote the accumulation of P-glycoprotein substrates in lung cancer A549 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 133-135 ATP binding cassette subfamily B member 1 Homo sapiens 205-219 23857029-5 2014 We then used regression analysis to predict the potency with which drugs inhibited CYP2D6.1 based on MM-GB/SA scores. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 83-89 24211871-5 2014 Treatment with MDP enhanced Sa.LTA-induced COX-2 and prostaglandin E2 production. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 28-30 prostaglandin-endoperoxide synthase 2 Mus musculus 43-48 24076428-4 2013 ROS-induced p38 activation was, in addition, shown to be reduced to one-third of the signal of the parental MES-SA cells 2h after PDT, and addition of the p38 inhibitor SB203580 confirmed p38 activation as a death signal after PDT in the MES-SA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 112-114 mitogen-activated protein kinase 14 Homo sapiens 12-15 24211871-7 2014 In addition, MDP enhanced Sa.LTA-induced activation of the transcription factors NF-kappaB and CRE, which are known to modulate COX-2 gene transcription. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 prostaglandin-endoperoxide synthase 2 Mus musculus 128-133 24076428-8 2013 The PARP I activation was, however, stronger after PCI than after PDT in the MES-SA cells, but not in the MES-SA/Dx5 cells, and therefore cannot explain the strong PCI effect in the MES-SA/Dx5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 poly(ADP-ribose) polymerase 1 Homo sapiens 4-8 24382184-0 2013 Modulation of multidrug resistance P-glycoprotein activity by antiemetic compounds in human doxorubicin-resistant sarcoma cells (MES-SA/Dx-5): implications on cancer therapy. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 133-135 ATP binding cassette subfamily B member 1 Homo sapiens 35-49 23674129-4 2013 Cytotoxicity was tested on 4 human cancer cell lines, while MDR reversal capacity was examined on P-glycoprotein overexpressing doxorubicin resistant MES-SA-DX5 and compared with non-resistant MES-SA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 154-156 ATP binding cassette subfamily B member 1 Homo sapiens 98-112 23711368-5 2013 Our results demonstrate that light-dependent ROS accumulation stimulates the degradation of chloroplastic proteins and up-regulates PAL-mediated SA synthesis, thus promoting FB1-induced light-dependent cell death. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 145-147 peptidylglycine alpha-amidating monooxygenase Homo sapiens 132-135 23872946-3 2013 Following depletion of DPY30, cells show a severe proliferation defect and display a senescent phenotype, including a flattened and enlarged morphology, elevated level of reactive oxygen species (ROS), increased SA-beta-galactosidase activity, and formation of senescence-associated heterochromatin foci (SAHFs). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 212-214 dpy-30 histone methyltransferase complex regulatory subunit Homo sapiens 23-28 23758386-5 2013 Both the ambient and high-pressure phases of SA crystallize in Pbca symmetry with similar unit-cell dimensions. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 45-47 PBCA Homo sapiens 63-67 23364341-7 2013 In the left ventricle of both WT and SA/SA mice, ANG II induced fibrosis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 49-55 23890153-14 2013 Furthermore, our results provide evidence that PAP5 acts upstream of SA accumulation to regulate the expression of other defense responsive genes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 69-71 purple acid phosphatase 5 Arabidopsis thaliana 47-51 23603962-4 2013 In a recent study we showed that AtMYB44 transcription factor positively regulates SA-mediated defense expression and enhanced resistance to Pst DC3000. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 83-85 myb domain protein r1 Arabidopsis thaliana 33-40 23603962-8 2013 This result shows that AtMYB44 is an integrator of cross-talk between SA and JA in plant defense responses. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 70-72 myb domain protein r1 Arabidopsis thaliana 23-30 23769064-9 2013 The survival effect was SA-FasL specific, with all NOD mice transplanted with control streptavidin protein-engineered islet grafts and treated with SA-engineered splenocytes under transient cover of rapamycin rejecting their grafts with an MST of 39.8 +- 8.5 days (P < .01). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 Fas ligand (TNF superfamily, member 6) Mus musculus 27-31 23736500-4 2013 Even in a mixture with 1 muM bovine serum albumin as the contaminant, 100 zM SA is detected, meaning a selectivity of 10(13). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 77-79 latexin Homo sapiens 25-28 23736500-4 2013 Even in a mixture with 1 muM bovine serum albumin as the contaminant, 100 zM SA is detected, meaning a selectivity of 10(13). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 77-79 albumin Homo sapiens 36-49 23364341-5 2013 ANG II increased mean arterial and systolic pressure in SA/SA and WT mice, but cardiac levels of cytokines associated with heart failure were increased less in SA/SA mice. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 0-6 23364341-7 2013 In the left ventricle of both WT and SA/SA mice, ANG II induced fibrosis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 37-39 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 49-55 23364341-11 2013 In contrast, cardiac myocytes of SA/SA+ANG II mice showed a loss in myofibrils and myofibrillar mass density was decreased during ANG II infusion. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 39-45 23364341-11 2013 In contrast, cardiac myocytes of SA/SA+ANG II mice showed a loss in myofibrils and myofibrillar mass density was decreased during ANG II infusion. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 130-136 23364341-11 2013 In contrast, cardiac myocytes of SA/SA+ANG II mice showed a loss in myofibrils and myofibrillar mass density was decreased during ANG II infusion. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 130-136 23415882-11 2013 GE1 cell proliferation as well as the expression of integrin-alpha6beta4 and laminin-5 (alpha3, beta3, gamma2) mRNAs was significantly higher on SA-treated c.p.Ti than on c.p.Ti and AO c.p.Ti disks after 3 days (P<0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 145-147 calcium channel, voltage-dependent, beta 3 subunit Mus musculus 96-101 22264674-10 2012 FAK protein was localized along cellular extensions on SA-treated c.p.Ti and the expression of FAK mRNA was significantly higher on these disks than on c.p.Ti and AO c.p.Ti after 72h (P<0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 55-57 PTK2 protein tyrosine kinase 2 Mus musculus 0-3 23080539-6 2013 Furthermore, overexpression of the catalytic subunit of the human telomerase (TERT) or conditional immortalization with a doxycycline-inducible system (TERT and SV40-TAg) result in telomere extension, but do not prevent SA-DNAm. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 220-222 telomerase reverse transcriptase Homo sapiens 78-82 23080539-6 2013 Furthermore, overexpression of the catalytic subunit of the human telomerase (TERT) or conditional immortalization with a doxycycline-inducible system (TERT and SV40-TAg) result in telomere extension, but do not prevent SA-DNAm. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 220-222 telomerase reverse transcriptase Homo sapiens 152-156 22274733-11 2013 SA treatment significantly (p < 0.05) increased the mRNA expression of PPAR gamma, thereby establishing the antilipidemic effect of the drug. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 peroxisome proliferator-activated receptor gamma Rattus norvegicus 74-84 23086458-6 2013 Energy calculation and decomposition using MM-GB/SA suggests that the van der Waals term (DeltaE(VDW)) is the main driving force for the binding of the partial agonists to alpha7-nAChR. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 49-51 cholinergic receptor nicotinic alpha 4 subunit Homo sapiens 179-184 23289011-10 2013 Plasma BNP level showed statistically significant differences among LAA (n = 71), CE (n = 50), and SA (n = 20) groups (p <0.001), and the expression decreased in order of CE (253.8 +- 337.1 pg/mL), LAA (61.6 +- 78.8 pg/mL), and SA (25.3 +- 24.8 pg/mL). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 natriuretic peptide B Homo sapiens 7-10 23289011-10 2013 Plasma BNP level showed statistically significant differences among LAA (n = 71), CE (n = 50), and SA (n = 20) groups (p <0.001), and the expression decreased in order of CE (253.8 +- 337.1 pg/mL), LAA (61.6 +- 78.8 pg/mL), and SA (25.3 +- 24.8 pg/mL). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 231-233 natriuretic peptide B Homo sapiens 7-10 22983699-6 2013 Furthermore, the SA-responsive defense-related genes including non-expressor of pathogenesis-related genes 1 (NPR1), PR1, PR2 were up-regulated and activities of some antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) were increased after the alpha-MMC treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 catalase isozyme 1 Nicotiana tabacum 225-233 22983699-6 2013 Furthermore, the SA-responsive defense-related genes including non-expressor of pathogenesis-related genes 1 (NPR1), PR1, PR2 were up-regulated and activities of some antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) were increased after the alpha-MMC treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 catalase isozyme 1 Nicotiana tabacum 235-238 22983699-6 2013 Furthermore, the SA-responsive defense-related genes including non-expressor of pathogenesis-related genes 1 (NPR1), PR1, PR2 were up-regulated and activities of some antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) were increased after the alpha-MMC treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 peroxidase N1 Nicotiana tabacum 241-251 22983699-6 2013 Furthermore, the SA-responsive defense-related genes including non-expressor of pathogenesis-related genes 1 (NPR1), PR1, PR2 were up-regulated and activities of some antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), peroxidase (POD) were increased after the alpha-MMC treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 peroxidase N1 Nicotiana tabacum 253-256 22965746-7 2012 The LARP1c null mutant 1c-1 impaired ABA-, SA-, and MeJA-induced leaf senescence in detached leaves. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 43-45 winged-helix DNA-binding transcription factor family protein Arabidopsis thaliana 4-10 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 interleukin 6 Homo sapiens 72-76 22445541-3 2012 Here, we showed that staphylococcal LTA (Sa.LTA) substantially enhanced IL-6 expression at both the protein and the mRNA levels in the human basophil line, KU812, in the presence of a PKC activator (phorbol 12-myristrate 13-acetate; PMA), and a calcium ionophore (A23187), whereas Sa.LTA alone could not induce IL-6 expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 interleukin 6 Homo sapiens 311-315 22445541-4 2012 PMA/A23187 augmented the expression of CD14 and TLR2 on the surface of KU812 cells and concomitantly increased the binding of fluorochrome-labeled Sa.LTA to the cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 147-149 CD14 molecule Homo sapiens 39-43 22445541-8 2012 Collectively, these results suggest that Sa.LTA exacerbates allergic inflammation by potentiating IL-6 production from activated basophils. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 interleukin 6 Homo sapiens 98-102 23117066-4 2012 We observed an increased level of reactive oxygen species, cellular damage in testes of SA-intoxicated mice and further analysed expressions of apoptotic signal proteins and mRNA like Bax, Bcl2 and caspase3. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 BCL2-associated X protein Mus musculus 184-187 23117066-4 2012 We observed an increased level of reactive oxygen species, cellular damage in testes of SA-intoxicated mice and further analysed expressions of apoptotic signal proteins and mRNA like Bax, Bcl2 and caspase3. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 B cell leukemia/lymphoma 2 Mus musculus 189-193 23117066-4 2012 We observed an increased level of reactive oxygen species, cellular damage in testes of SA-intoxicated mice and further analysed expressions of apoptotic signal proteins and mRNA like Bax, Bcl2 and caspase3. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 caspase 3 Mus musculus 198-206 22306536-8 2012 Similarly to losartan, ASA, and its SA moiety suppressed Ang II-mediated AT1R transcription and fibroblast proliferation as well as expression of collagens and MMPs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 57-63 22580578-1 2012 A deletion in the high affinity nitrate trasporter NRT2.1 in Arabidopsis results in a reduced susceptibility to Pseudomonas syringae by two different mechanisms, the SA priming and an interference in the effector triggered susceptibility. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 166-168 nitrate transporter 2:1 Arabidopsis thaliana 51-55 22580578-3 2012 Despite the priming found in the SA-dependent pathway, the metabolic changes in nrt2 compared with wild-type plants are more remarkable prior infection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 nitrate transporter 2:1 Arabidopsis thaliana 80-84 22350182-5 2012 Compared with the 8-MOP/UVA treatment group, we found that the irradiated fibroblasts pretreated with ginsenoside Rg1 demonstrated a decrease in the expression of SA-beta-gal, a downregulation in the level of senescence-associated proteins, and a deceleration in telomere shortening. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 163-165 protein phosphatase 1 regulatory subunit 3A Homo sapiens 114-117 22905613-9 2012 And the percentage of SA-Pbetagal-positive NP cells in the p53 siRNA transfection group and p21 siRNA transfection group were significantly lower than that in control group (P < 0.001). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 22-24 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 59-62 21946941-6 2012 Only trace amounts of MMP-9 activity were detected in 4 of 10 patients with RA, whereas higher MMP-9 levels were evident in all samples from SA (P = 0.0241). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 141-143 matrix metallopeptidase 9 Homo sapiens 95-100 22883451-6 2012 RESULTS: The IL-4-SA fusion protein was durably anchored to the biotinylated mucosal surface of bladder wall for up to 5 days.On day 80 after the implantation of MB49 cells, all of PBS-treated mice died, and 8 out of 10 mice in the GFP-SA-treated group died from tumor burden.In contrast, 5 out of 10 mice in the IL-4-SA-treated group were tumor-free. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 interleukin 4 Mus musculus 13-17 22006107-9 2012 ZmMPK17-overexpressing plants displayed enhanced resistance to viral pathogens, and the expression of the pathogenesis-related gene PR1a was significantly increased, indicating that ZmMPK17 might be involved in SA-mediated pathogen defense-signaling pathways. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 211-213 Mitogen-activated protein kinase 13 Zea mays 0-7 22006107-9 2012 ZmMPK17-overexpressing plants displayed enhanced resistance to viral pathogens, and the expression of the pathogenesis-related gene PR1a was significantly increased, indicating that ZmMPK17 might be involved in SA-mediated pathogen defense-signaling pathways. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 211-213 Mitogen-activated protein kinase 13 Zea mays 182-189 22492810-3 2012 Reduction in 18:1 levels, via a genetic mutation in the 18:1-synthesizing gene SUPPRESSOR OF SA INSENSITIVITY OF npr1-5 (SSI2) or exogenous application of glycerol, induced NO accumulation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 93-95 regulatory protein (NPR1) Arabidopsis thaliana 113-119 22306536-8 2012 Similarly to losartan, ASA, and its SA moiety suppressed Ang II-mediated AT1R transcription and fibroblast proliferation as well as expression of collagens and MMPs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 angiotensin II, type I receptor-associated protein Mus musculus 73-77 22306536-13 2012 Since SA had similar effect as ASA on AT1R expression, we suggest that ASA"s effect is mediated by its SA moiety. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 angiotensin II, type I receptor-associated protein Mus musculus 38-42 22258659-4 2012 RESULTS: Serum levels of AMH in women with FSHRO were comparable with those in control women (2.76 +- 2.37 versus 3.77 +- 2.36 ng/ml) and significantly higher than in women with PA (0.05 +- 0.04 ng/ml; P < 0.001) or SA of unknown origin (0.12 +- 0.20 ng/ml; P < 0.001). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 219-221 anti-Mullerian hormone Homo sapiens 25-28 22276544-3 2012 Understanding the conditions under which SA polymorphism can exist at such pseudo-autosomal (or PAR) loci should increase understanding of the evolution of recombination between sex chromosome pairs, and can help predict when we may expect potentially empirically detectable allele frequency differences between the sexes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 jumping translocation breakpoint Homo sapiens 96-99 21658000-8 2012 Considering the ESR1 and FSHR gene polymorphisms in combination, the TC/SA combination presents the highest number of pregnancies in poor responders group (3/4 pregnancies carried this genotype), in good responders group (4/12 pregnancies carried this genotype) and in the total population (10/26 pregnancies carried this genotype). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 estrogen receptor 1 Homo sapiens 16-20 21658000-8 2012 Considering the ESR1 and FSHR gene polymorphisms in combination, the TC/SA combination presents the highest number of pregnancies in poor responders group (3/4 pregnancies carried this genotype), in good responders group (4/12 pregnancies carried this genotype) and in the total population (10/26 pregnancies carried this genotype). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 follicle stimulating hormone receptor Homo sapiens 25-29 21658000-14 2012 CONCLUSION: This study supports the hypothesis that a multigenic model, including the well studied ESR1 and FSHR genes is involved in the controlled ovarian stimulation outcome indicating that the CC/AA genotype presents the worst ovulation induction profile, while the TC/SA genotype presents the higher number of pregnancies in our population. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 273-275 estrogen receptor 1 Homo sapiens 99-103 21658000-14 2012 CONCLUSION: This study supports the hypothesis that a multigenic model, including the well studied ESR1 and FSHR genes is involved in the controlled ovarian stimulation outcome indicating that the CC/AA genotype presents the worst ovulation induction profile, while the TC/SA genotype presents the higher number of pregnancies in our population. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 273-275 follicle stimulating hormone receptor Homo sapiens 108-112 22276544-6 2012 We confirm the previous major conclusion that SA polymorphisms are generally maintained in a larger region of parameter space if the locus is in the PAR than if it is autosomal. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 jumping translocation breakpoint Homo sapiens 149-152 22281341-8 2012 In the Ph-SA group, increases in the mRNA expression of TLR2, TNF-alpha, IL-1beta, IL-6, IL-8, and lactoferrin were observed at 6 h postinfection, and an increase in TLR4 mRNA expression was observed at 24 h postinfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 toll like receptor 4 Bos taurus 166-170 22281341-10 2012 In conclusion, Ph-SA might promote the expression of mRNA for TLR2, TLR4, the pro-inflammatory cytokines IL-1, IL-6, and TNF-alpha, the chemotactic factor IL-8, and lactoferrin in Staph. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 toll like receptor 2 Bos taurus 62-66 22281341-8 2012 In the Ph-SA group, increases in the mRNA expression of TLR2, TNF-alpha, IL-1beta, IL-6, IL-8, and lactoferrin were observed at 6 h postinfection, and an increase in TLR4 mRNA expression was observed at 24 h postinfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 toll like receptor 2 Bos taurus 56-60 22281341-10 2012 In conclusion, Ph-SA might promote the expression of mRNA for TLR2, TLR4, the pro-inflammatory cytokines IL-1, IL-6, and TNF-alpha, the chemotactic factor IL-8, and lactoferrin in Staph. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 toll like receptor 4 Bos taurus 68-72 22281341-8 2012 In the Ph-SA group, increases in the mRNA expression of TLR2, TNF-alpha, IL-1beta, IL-6, IL-8, and lactoferrin were observed at 6 h postinfection, and an increase in TLR4 mRNA expression was observed at 24 h postinfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 tumor necrosis factor Bos taurus 62-71 22281341-10 2012 In conclusion, Ph-SA might promote the expression of mRNA for TLR2, TLR4, the pro-inflammatory cytokines IL-1, IL-6, and TNF-alpha, the chemotactic factor IL-8, and lactoferrin in Staph. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 interferon beta-2 Bos taurus 111-115 22281341-8 2012 In the Ph-SA group, increases in the mRNA expression of TLR2, TNF-alpha, IL-1beta, IL-6, IL-8, and lactoferrin were observed at 6 h postinfection, and an increase in TLR4 mRNA expression was observed at 24 h postinfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 interleukin 1 beta Bos taurus 73-81 22281341-8 2012 In the Ph-SA group, increases in the mRNA expression of TLR2, TNF-alpha, IL-1beta, IL-6, IL-8, and lactoferrin were observed at 6 h postinfection, and an increase in TLR4 mRNA expression was observed at 24 h postinfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 interferon beta-2 Bos taurus 83-87 22281341-8 2012 In the Ph-SA group, increases in the mRNA expression of TLR2, TNF-alpha, IL-1beta, IL-6, IL-8, and lactoferrin were observed at 6 h postinfection, and an increase in TLR4 mRNA expression was observed at 24 h postinfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 C-X-C motif chemokine ligand 8 Bos taurus 89-93 22281341-8 2012 In the Ph-SA group, increases in the mRNA expression of TLR2, TNF-alpha, IL-1beta, IL-6, IL-8, and lactoferrin were observed at 6 h postinfection, and an increase in TLR4 mRNA expression was observed at 24 h postinfection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 lactotransferrin Bos taurus 99-110 22281341-10 2012 In conclusion, Ph-SA might promote the expression of mRNA for TLR2, TLR4, the pro-inflammatory cytokines IL-1, IL-6, and TNF-alpha, the chemotactic factor IL-8, and lactoferrin in Staph. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 tumor necrosis factor Bos taurus 121-130 22281341-10 2012 In conclusion, Ph-SA might promote the expression of mRNA for TLR2, TLR4, the pro-inflammatory cytokines IL-1, IL-6, and TNF-alpha, the chemotactic factor IL-8, and lactoferrin in Staph. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 C-X-C motif chemokine ligand 8 Bos taurus 155-159 22281341-10 2012 In conclusion, Ph-SA might promote the expression of mRNA for TLR2, TLR4, the pro-inflammatory cytokines IL-1, IL-6, and TNF-alpha, the chemotactic factor IL-8, and lactoferrin in Staph. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 lactotransferrin Bos taurus 165-176 22072959-9 2011 However, only EDS1 is required for HRT-mediated HR to TCV, while only PAD4 is required for SA-dependent induction of HRT. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 peptidyl arginine deiminase 4 Homo sapiens 70-74 21681549-4 2012 Analysis of gene expression data with one-way ANOVA, geNorm and NormFinder identified HIST and YWHAZ as the least affected during the induction of apoptosis by the different treatments, and is the most suitable gene-pair for normalization during qPCR analysis in MCF-7 breast cancer cells undergoing apoptosis following treatment with SA and/or HS. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 335-337 tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta Homo sapiens 95-100 23366596-2 2012 We transiently transfected PGP labeled with enhanced green fluorescent protein (PGP-EGFP) into MES-SA cells and used single molecule tracking techniques to characterize the dynamics on the surface of live cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 phosphoglycolate phosphatase Homo sapiens 27-30 22988542-9 2012 Significant differences were observed in median serum-NGAL(ng/mL) between patients with SA (79.23 (IQR, 37.50-100.32)), when compared with UA (108.00 (68.34-177.59)), NSTEMI (166.49 (109.24-247.20)), and STEMI (178.63 (111.18-305.92)) patients and controls (50.31 (44.30-69.78)) with significant incremental value from SA to STEMI. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 lipocalin 2 Homo sapiens 54-58 21947138-9 2012 As shown by Western blot analysis and immunodetection, NM treatment resulted in a dose-dependent decrease in Pgp expression in the MES-SA/Dx5 cell line. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 159-161 ATP binding cassette subfamily B member 1 Homo sapiens 133-136 22927901-3 2012 R-HepG2 and MES-SA/Dx5 cells are doxorubicin induced P-gp over-expressed MDR sublines of human hepatocellular carcinoma HepG2 cells and human uterine carcinoma MES-SA cells respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 16-18 ATP binding cassette subfamily B member 1 Homo sapiens 53-57 22675523-5 2012 To better understand how DPP6 variants shape native neuronal I(SA), we focused on studying interactions between the two dominant variants, DPP6K and DPP6a. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 63-65 dipeptidyl peptidase like 6 Rattus norvegicus 25-29 22032700-10 2012 The positive rate of SA-beta-gal staining was increased; the telomere length was shortened; and the expressions of p16 and p21 were increased. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 21-23 cyclin dependent kinase inhibitor 2A Homo sapiens 115-118 22032700-10 2012 The positive rate of SA-beta-gal staining was increased; the telomere length was shortened; and the expressions of p16 and p21 were increased. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 21-23 H3 histone pseudogene 16 Homo sapiens 123-126 22268143-7 2012 Expression in wild-type and salicylic acid-deficient mutants suggests a common but not exclusive role for SA in induction of WRKY30, 53, 54, and 70 during senescence. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 106-108 WRKY DNA-binding protein 30 Arabidopsis thaliana 125-131 21605668-8 2011 In addition, A549 and MES-SA cells were shown to be good cell models for studying interactions of compounds with human MRP2. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 ATP binding cassette subfamily C member 2 Homo sapiens 119-123 21690381-5 2011 Anoxia increased endogenous slow phasic GABAergic activity, and both anoxia and GABA reversibly induced SA by increasing GABA(A)R-mediated postsynaptic activity and Cl(-) conductance, which eliminated the Cl(-) driving force by depolarizing membrane potential (~8 mV) to GABA receptor reversal potential (~-81 mV), and dampened excitatory potentials via shunting inhibition. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 104-106 GABA type A receptor-associated protein Homo sapiens 271-284 21605337-7 2011 We conclude that different SA subjects were observed to differentially associate with two novel GxEs involving exposures to PA with different life timing and SNPs located in opposite ends of CRHR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 27-29 corticotropin releasing hormone receptor 1 Homo sapiens 191-196 21472730-5 2011 The crystal forms of SA and SSU.MeOH were determined to be triclinic, (Pi), and monoclinic, (P2(1) /n), respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 21-23 cyclin dependent kinase inhibitor 1A Homo sapiens 93-98 20712342-5 2010 Here we describe the performance of a modified MM-PB/SA method on 222 Wee1 kinase inhibitors (48 pyridopyrimidine and 174 pyrrolocarbazole derivatives). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 53-55 WEE1 G2 checkpoint kinase Homo sapiens 70-74 21722410-1 2011 In Arabidopsis, non-expressor of pathogenesis related genes-1, NPR1 has been shown to be a positive regulator of the salicylic acid controlled systemic acquired resistance pathway and modulates the cross talk between SA and JA signaling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 217-219 regulatory protein (NPR1) Arabidopsis thaliana 63-67 21880209-9 2011 These results are consistent with the increase in Pgp expression levels in parental MES-SA cells treated with 3, 6 and 12 muM DEHP for 24 h and compared to untreated controls. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 ATP binding cassette subfamily B member 1 Homo sapiens 50-53 21880209-9 2011 These results are consistent with the increase in Pgp expression levels in parental MES-SA cells treated with 3, 6 and 12 muM DEHP for 24 h and compared to untreated controls. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 latexin Homo sapiens 122-125 21324654-8 2011 CHL, CHE and SA induced apoptosis, which was probably mediated by decreasing levels of anti-apoptotic proteins (Bcl-xL, Mcl-1, XIAP) and was accompanied by mitochondrial membrane potential decrease as well as caspase-3 and PARP cleavage. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 BCL2 like 1 Homo sapiens 112-118 21324654-8 2011 CHL, CHE and SA induced apoptosis, which was probably mediated by decreasing levels of anti-apoptotic proteins (Bcl-xL, Mcl-1, XIAP) and was accompanied by mitochondrial membrane potential decrease as well as caspase-3 and PARP cleavage. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 MCL1 apoptosis regulator, BCL2 family member Homo sapiens 120-125 21324654-8 2011 CHL, CHE and SA induced apoptosis, which was probably mediated by decreasing levels of anti-apoptotic proteins (Bcl-xL, Mcl-1, XIAP) and was accompanied by mitochondrial membrane potential decrease as well as caspase-3 and PARP cleavage. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 X-linked inhibitor of apoptosis Homo sapiens 127-131 21324654-8 2011 CHL, CHE and SA induced apoptosis, which was probably mediated by decreasing levels of anti-apoptotic proteins (Bcl-xL, Mcl-1, XIAP) and was accompanied by mitochondrial membrane potential decrease as well as caspase-3 and PARP cleavage. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 caspase 3 Homo sapiens 209-218 21324654-8 2011 CHL, CHE and SA induced apoptosis, which was probably mediated by decreasing levels of anti-apoptotic proteins (Bcl-xL, Mcl-1, XIAP) and was accompanied by mitochondrial membrane potential decrease as well as caspase-3 and PARP cleavage. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 collagen type XI alpha 2 chain Homo sapiens 223-227 22210962-1 2011 We report a Quantum mechanics/Molecular Mechanics-Poisson-Boltzmann/ Surface Area (QM/MM-PB/SA) method to calculate the binding free energy of c-Abl human tyrosine kinase by combining the QM and MM principles where the ligand is treated quantum mechanically and the rest of the receptor by classical molecular mechanics. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 92-94 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 143-148 21557685-4 2011 TF-activity of isolated mononuclear cells (MNC) was elevated in UA/NSTEMI (75 +- 27 pg/mL) in comparison to SA (47 +- 17 pg/mL, p = 0.001) as determined by chromogenic assay, and TF mRNA expression in isolated MNC was more frequent in UA/NSTEMI than in SA (50% vs. 18.2%; p = 0.017). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 253-255 coagulation factor III, tissue factor Homo sapiens 0-2 20658486-6 2010 RESULTS: Serum TNF-alpha was >150 pg/ml in nine SA versus 10 SP rats. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 51-53 tumor necrosis factor Rattus norvegicus 15-24 20658486-9 2010 Pleural TNF-alpha was similar in both groups (P = 0.92), but serum TNF-alpha was significantly higher in SA (P = 0.03). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 105-107 tumor necrosis factor Rattus norvegicus 67-76 21718946-7 2011 RESULTS: The transport of [(11)C]TPT to the extracellular side was determined in MES-SA/Dx5 cells exhibiting the expressions of Pgp and BCRP at high levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 phosphoglycolate phosphatase Homo sapiens 128-131 21718946-7 2011 RESULTS: The transport of [(11)C]TPT to the extracellular side was determined in MES-SA/Dx5 cells exhibiting the expressions of Pgp and BCRP at high levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 ATP binding cassette subfamily G member 2 (Junior blood group) Homo sapiens 136-140 21217075-8 2011 Both BNP and ET-1 correlated positively with mPAP and negatively with Sa(O(2)), whereas serum VEGF levels were inversely correlated with Sa(O(2)); eNOS correlated negatively with mPAP and positively with Sa(O(2)). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 70-72 natriuretic peptide B Homo sapiens 5-8 21217075-8 2011 Both BNP and ET-1 correlated positively with mPAP and negatively with Sa(O(2)), whereas serum VEGF levels were inversely correlated with Sa(O(2)); eNOS correlated negatively with mPAP and positively with Sa(O(2)). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 70-72 endothelin 1 Homo sapiens 13-17 21217075-8 2011 Both BNP and ET-1 correlated positively with mPAP and negatively with Sa(O(2)), whereas serum VEGF levels were inversely correlated with Sa(O(2)); eNOS correlated negatively with mPAP and positively with Sa(O(2)). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 137-139 vascular endothelial growth factor A Homo sapiens 94-98 21217075-8 2011 Both BNP and ET-1 correlated positively with mPAP and negatively with Sa(O(2)), whereas serum VEGF levels were inversely correlated with Sa(O(2)); eNOS correlated negatively with mPAP and positively with Sa(O(2)). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 137-139 vascular endothelial growth factor A Homo sapiens 94-98 21315683-1 2011 We have demonstrated that protein kinase Cdelta (PKCdelta) could be involved in macrophage apoptosis induced by cationic liposomes composed of stearylamine (SA-liposomes), but the detailed mechanism of how SA-liposomes activate PKCdelta has remained unclear. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 157-159 protein kinase C delta Homo sapiens 26-47 21315683-1 2011 We have demonstrated that protein kinase Cdelta (PKCdelta) could be involved in macrophage apoptosis induced by cationic liposomes composed of stearylamine (SA-liposomes), but the detailed mechanism of how SA-liposomes activate PKCdelta has remained unclear. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 157-159 protein kinase C delta Homo sapiens 49-57 21315683-1 2011 We have demonstrated that protein kinase Cdelta (PKCdelta) could be involved in macrophage apoptosis induced by cationic liposomes composed of stearylamine (SA-liposomes), but the detailed mechanism of how SA-liposomes activate PKCdelta has remained unclear. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 206-208 protein kinase C delta Homo sapiens 26-47 21315683-1 2011 We have demonstrated that protein kinase Cdelta (PKCdelta) could be involved in macrophage apoptosis induced by cationic liposomes composed of stearylamine (SA-liposomes), but the detailed mechanism of how SA-liposomes activate PKCdelta has remained unclear. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 206-208 protein kinase C delta Homo sapiens 49-57 21315683-2 2011 In this paper, we clarified whether lipid rafts are involved in the PKCdelta activation induced by SA-liposomes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 99-101 protein kinase C delta Homo sapiens 68-76 21315683-5 2011 Activation of PKCdelta and externalization of phosphatidylserine induced by SA-liposomes were also suppressed by DM-alpha-CD, which extracts sphingolipids and proteins from lipid rafts. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 76-78 protein kinase C delta Homo sapiens 14-22 20621639-1 2010 In this study five macrolide antibiotics (azithromycin, erythromycin, clarithromycin, roxithromycin and telithromycin) were compared based on their ability to interact with human MDR1 (ABCB1, P-glycoprotein), studied from two main aspects: by determining the influence of macrolide antibiotics on MDR1 function, as well as the influence of MDR1 on macrolide accumulation in MES-SA/Dx5 cells overexpressing human MDR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 378-380 ATP binding cassette subfamily B member 1 Homo sapiens 179-183 20621639-1 2010 In this study five macrolide antibiotics (azithromycin, erythromycin, clarithromycin, roxithromycin and telithromycin) were compared based on their ability to interact with human MDR1 (ABCB1, P-glycoprotein), studied from two main aspects: by determining the influence of macrolide antibiotics on MDR1 function, as well as the influence of MDR1 on macrolide accumulation in MES-SA/Dx5 cells overexpressing human MDR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 378-380 ATP binding cassette subfamily B member 1 Homo sapiens 185-190 20659700-4 2010 RESULTS: Notch4 overexpression in SA (n = 19/23; 82.6%) compared with UA (n = 1/22; 4.5%) or RA (n = 10/19; 52.6%) (P < .05) suggests positive correlation between Notch4 signaling and ameloblastomas with a solid/multicystic phenotype. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 notch receptor 4 Homo sapiens 9-15 19960428-1 2010 In this study, we evaluated whether euphorbiasteroid isolated from Euphorbia lathyris has the potential to reverse P-glycoprotein (P-gp)-mediated multi-drug resistance (MDR) by using the drug-sensitive human sarcoma cell line MES-SA and its MDR counterpart MES-SA/Dx5. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 230-232 ATP binding cassette subfamily B member 1 Homo sapiens 131-135 20235592-5 2010 In the former, replacing the GB/SA protein desolvation in the MM-GB/SA method by the free energy associated with displacing binding site waters upon ligand binding estimated by WaterMap provides the best results when ranking congeneric series of factor Xa and cyclin-dependent kinase 2 (CDK2) inhibitors. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 coagulation factor X Homo sapiens 246-255 20235592-5 2010 In the former, replacing the GB/SA protein desolvation in the MM-GB/SA method by the free energy associated with displacing binding site waters upon ligand binding estimated by WaterMap provides the best results when ranking congeneric series of factor Xa and cyclin-dependent kinase 2 (CDK2) inhibitors. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 68-70 coagulation factor X Homo sapiens 246-255 20461025-6 2010 The CECs/MNC ratio and FI-S100A12-CECs level in patients with SA-KD with CALs were significantly higher than in patients with SA-KD without CALs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 S100 calcium binding protein A12 Homo sapiens 26-33 20661301-5 2010 The phage-resistant strain A172 was isolated from the phage-sensitive strain A170 in the presence of the M(Sa) phage. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 sequestosome 1 Mus musculus 77-81 20590846-10 2010 At 12 months of age, SMP30-knockout mice had clearly visible deposits of lipofuscin and senescence-associated beta-galactosidase (SA-beta-GAL) in their renal tubular epithelia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 regucalcin Mus musculus 21-26 20483756-7 2010 Although a decrease in the clinical signs of arthritis was observed in Foxp3tg bone marrow-transferred and CD28 SA-treated hTNFtg mice, the bone-protective effect of Treg cells was independent of the suppression of inflammation, as demonstrated by the increased systemic bone density observed in wild-type mice treated with CD28 SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 112-114 CD28 antigen Mus musculus 107-111 20501361-9 2010 Five out of 9 tumor-free mice in SA-hTNF-alpha group showed resistance to a re-challenge with intravesical MB49. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 tumor necrosis factor Homo sapiens 36-46 20646556-5 2010 According to different therapeutic strategies, three groups were set up: SA-FasL group (n = 23), SA group (n = 20) and naive splenocytes only group (n = 8). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 73-75 Fas ligand Rattus norvegicus 76-80 20122929-3 2010 Tyrosine phosphorylation, nuclear localization, and cleavage of PKCdelta were observed following the treatment of cells with SA-liposomes, suggesting that SA-liposomes activate PKCdelta. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 125-127 protein kinase C, delta Mus musculus 64-72 20122929-3 2010 Tyrosine phosphorylation, nuclear localization, and cleavage of PKCdelta were observed following the treatment of cells with SA-liposomes, suggesting that SA-liposomes activate PKCdelta. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 125-127 protein kinase C, delta Mus musculus 177-185 20122929-3 2010 Tyrosine phosphorylation, nuclear localization, and cleavage of PKCdelta were observed following the treatment of cells with SA-liposomes, suggesting that SA-liposomes activate PKCdelta. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 155-157 protein kinase C, delta Mus musculus 64-72 20122929-3 2010 Tyrosine phosphorylation, nuclear localization, and cleavage of PKCdelta were observed following the treatment of cells with SA-liposomes, suggesting that SA-liposomes activate PKCdelta. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 155-157 protein kinase C, delta Mus musculus 177-185 20122929-5 2010 Cell surface proteoglycans may contribute to PKCdelta activation by SA-liposomes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 68-70 protein kinase C, delta Mus musculus 45-53 20122929-6 2010 These findings suggest that PKCdelta is strongly associated with apoptosis induced by SA-liposomes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 86-88 protein kinase C, delta Mus musculus 28-36 19914915-4 2010 The PE-labeled OS-9(MRH)-SA bound to HeLaS3 cells in a metal ion-independent manner through amino acid residues homologous to those participating in sugar binding of the cation-dependent mannose 6-phosphate receptor, and this binding was greatly increased by swainsonine, deoxymannojirimycin, or kifunensine treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 25-27 OS9 endoplasmic reticulum lectin Homo sapiens 15-19 19914915-4 2010 The PE-labeled OS-9(MRH)-SA bound to HeLaS3 cells in a metal ion-independent manner through amino acid residues homologous to those participating in sugar binding of the cation-dependent mannose 6-phosphate receptor, and this binding was greatly increased by swainsonine, deoxymannojirimycin, or kifunensine treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 25-27 OS9 endoplasmic reticulum lectin Homo sapiens 20-23 19914915-6 2010 OS-9(MRH)-SA binding to the cells was strongly inhibited by Manalpha1,6(Manalpha1,3)Manalpha1,6(Manalpha1,3)Man and Manalpha1,6Man. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 OS9 endoplasmic reticulum lectin Homo sapiens 0-4 19914915-4 2010 The PE-labeled OS-9(MRH)-SA bound to HeLaS3 cells in a metal ion-independent manner through amino acid residues homologous to those participating in sugar binding of the cation-dependent mannose 6-phosphate receptor, and this binding was greatly increased by swainsonine, deoxymannojirimycin, or kifunensine treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 25-27 mannose-6-phosphate receptor, cation dependent Homo sapiens 170-215 19914915-6 2010 OS-9(MRH)-SA binding to the cells was strongly inhibited by Manalpha1,6(Manalpha1,3)Manalpha1,6(Manalpha1,3)Man and Manalpha1,6Man. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 OS9 endoplasmic reticulum lectin Homo sapiens 5-8 21063092-7 2010 Ang II (10(-6) M) increased this parameter only in SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 51-53 angiogenin Cricetulus griseus 0-3 20044255-3 2010 The discrepancy in FFA concentrations between the two studies suggested that the in vivo target of the SA compounds might not be limited to PTP1B. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 103-105 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 140-145 20044255-6 2010 Inhibition of IKK-beta, in addition to inhibition of PTP1B, in mice treated with the SA compounds, could be a possible mechanism of the compound"s biological response including the resistance to diet-induced weight gain and improvement in blood parameters. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 inhibitor of kappaB kinase beta Mus musculus 14-22 20044255-6 2010 Inhibition of IKK-beta, in addition to inhibition of PTP1B, in mice treated with the SA compounds, could be a possible mechanism of the compound"s biological response including the resistance to diet-induced weight gain and improvement in blood parameters. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 protein tyrosine phosphatase, non-receptor type 1 Mus musculus 53-58 20230665-7 2010 They exhibited the bi-functionality: proliferation-promoting activity of mIL15 on mouse spleen lymphocytes with the specific activity of 1x10(6); IU/mg for SA-mIL15 or 2 x 10(5); IU/mg for mIL15-SA, and SA-mediated high-affinity binding to the biotinylated surfaces of RM-1 tumor cells with about 95% surface modification efficiency. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 156-158 interleukin 15 Mus musculus 73-78 20230665-7 2010 They exhibited the bi-functionality: proliferation-promoting activity of mIL15 on mouse spleen lymphocytes with the specific activity of 1x10(6); IU/mg for SA-mIL15 or 2 x 10(5); IU/mg for mIL15-SA, and SA-mediated high-affinity binding to the biotinylated surfaces of RM-1 tumor cells with about 95% surface modification efficiency. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 156-158 interleukin 15 Mus musculus 159-164 20230665-7 2010 They exhibited the bi-functionality: proliferation-promoting activity of mIL15 on mouse spleen lymphocytes with the specific activity of 1x10(6); IU/mg for SA-mIL15 or 2 x 10(5); IU/mg for mIL15-SA, and SA-mediated high-affinity binding to the biotinylated surfaces of RM-1 tumor cells with about 95% surface modification efficiency. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 156-158 interleukin 15 Mus musculus 159-164 20230665-7 2010 They exhibited the bi-functionality: proliferation-promoting activity of mIL15 on mouse spleen lymphocytes with the specific activity of 1x10(6); IU/mg for SA-mIL15 or 2 x 10(5); IU/mg for mIL15-SA, and SA-mediated high-affinity binding to the biotinylated surfaces of RM-1 tumor cells with about 95% surface modification efficiency. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 195-197 interleukin 15 Mus musculus 73-78 19427413-5 2010 The anti-Sa antibody has been identified a decade ago; however, recent studies confirmed that anti-Sa is directed against citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 vimentin Homo sapiens 136-144 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 WD repeat domain 6 Homo sapiens 107-111 20045976-7 2010 However, a new type of low-carbon-content and polar-endcapped C18 phase column was developed for better separation of SA from the matrix. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 118-120 Bardet-Biedl syndrome 9 Homo sapiens 62-65 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 DALR anticodon binding domain containing 3 Homo sapiens 113-119 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 NADH:ubiquinone oxidoreductase complex assembly factor 3 Homo sapiens 121-128 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 RNANC Homo sapiens 133-138 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 microRNA 425 Homo sapiens 151-158 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 microRNA 191 Homo sapiens 163-170 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 RNANC Homo sapiens 210-215 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 dicer 1, ribonuclease III Homo sapiens 245-251 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 basonuclin 2 Homo sapiens 256-268 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 microRNA 425 Homo sapiens 284-291 19906709-9 2010 Specifically, we revealed complex SA structural-functional gene module composing the protein-coding genes, WDR6, DALRD3, NDUFAF3 and ncRNA precursors, mir-425 and mir-191, which could provide downregulation of ncRNA pathway via direct targeting DICER1 and basonuclin 2 transcripts by mir-425 and mir-191 in normal spermatogenesis, but this mechanism is switched off in severe teratozoospermia. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 microRNA 191 Homo sapiens 296-303 19401579-4 2009 The SA method was significantly more efficient (mean processing time, 53 minutes vs 156 minutes for SA1 vs M1 and 53 minutes vs 118 minutes for SA2 vs M2; P < .001) and reproducible (mean volume overlap, 94.3% vs 87.8% for the SA method vs the M method; P < .001) than the M method. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 stromal antigen 1 Homo sapiens 100-103 19607808-16 2009 Transient coexpression of OsBWMK1 and OsWRKY33 in Arabidopsis protoplasts elevates SA-dependent expression of the GUS-reporter gene driven by the W-box element and the PR1 promoter. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 83-85 pathogenesis-related protein 1 Arabidopsis thaliana 168-171 19839340-6 2009 However, there was a decrease in the photosynthetic efficiency and even a stress of the cpr5 leaves with 100 and 300 micromol x L(-1) SA treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 134-136 CPR5 protein Arabidopsis thaliana 88-92 19318349-7 2009 These findings strongly suggest a new pathway to regulate senescence phenotypes by ROS via Sp1 phosphorylation between PKCalpha and SA-pErk1/2: employing GST-Sp1 mutants and MEK inhibitor analyses, we found that SA-pErk1/2 regulated Sp1 phosphorylation on the Ser(59) residue in vivo, but not threonine, in cellular senescence, which regulated transcription of p21(Sdi1) expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 132-134 mitogen-activated protein kinase kinase 7 Homo sapiens 174-177 19318349-7 2009 These findings strongly suggest a new pathway to regulate senescence phenotypes by ROS via Sp1 phosphorylation between PKCalpha and SA-pErk1/2: employing GST-Sp1 mutants and MEK inhibitor analyses, we found that SA-pErk1/2 regulated Sp1 phosphorylation on the Ser(59) residue in vivo, but not threonine, in cellular senescence, which regulated transcription of p21(Sdi1) expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 132-134 cyclin dependent kinase inhibitor 1A Homo sapiens 361-364 19318349-7 2009 These findings strongly suggest a new pathway to regulate senescence phenotypes by ROS via Sp1 phosphorylation between PKCalpha and SA-pErk1/2: employing GST-Sp1 mutants and MEK inhibitor analyses, we found that SA-pErk1/2 regulated Sp1 phosphorylation on the Ser(59) residue in vivo, but not threonine, in cellular senescence, which regulated transcription of p21(Sdi1) expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 132-134 cyclin dependent kinase inhibitor 1A Homo sapiens 365-369 19141611-8 2009 Mutation of the Ser (SA) or Thr (TA) residue to Ala in the motif markedly impaired its ability to interact with Axin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 21-23 axin 1 Homo sapiens 112-116 19721011-4 2009 This protection strongly relied on the presence of CD28-SA-activated CD4+ CD25+ Foxp3+ regulatory T cells in the donor T-cell inoculum. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 CD28 molecule Homo sapiens 51-55 19721011-4 2009 This protection strongly relied on the presence of CD28-SA-activated CD4+ CD25+ Foxp3+ regulatory T cells in the donor T-cell inoculum. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 CD4 molecule Homo sapiens 69-72 19721011-4 2009 This protection strongly relied on the presence of CD28-SA-activated CD4+ CD25+ Foxp3+ regulatory T cells in the donor T-cell inoculum. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 interleukin 2 receptor subunit alpha Homo sapiens 74-78 19721011-4 2009 This protection strongly relied on the presence of CD28-SA-activated CD4+ CD25+ Foxp3+ regulatory T cells in the donor T-cell inoculum. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 forkhead box P3 Homo sapiens 80-85 19809191-5 2009 Induction of PR-2 was dependent on SA signaling and ET signaling, and the elicitor in the IF was associated with molecules in the range of >100 kDa. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 35-37 beta-1,3-glucanase 2 Arabidopsis thaliana 13-17 19699120-2 2009 STUDY DESIGN: Immunohistochemical study was performed for Twist protein in 53 ameloblastomas (32 solid/multicystic [SA] and 21 unicystic [UA]). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 116-118 twist family bHLH transcription factor 1 Homo sapiens 58-63 19699120-3 2009 RESULTS: The salient finding was that expression of Twist was related to the histological subtype of tumors, as there was a higher expression in SA (14/32, 43.75%) as compared to UA (4/21, 19.05%) (P < .05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 145-147 twist family bHLH transcription factor 1 Homo sapiens 52-57 19555661-2 2009 The helical propensity of a peptide corresponding to beta2-strand of salivary SA cystatin analyzed by CD display high helical propensity in aqueous solution, whereas peptides matching the beta2-strand amino acid sequence of cystatins S and SN, display random coil conformation in aqueous solution but acquire alpha-helical conformation in the presence of trifluoroethanol (TFE). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 78-80 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 53-58 19657776-12 2009 Moreover, reactivities of anti-Sa on WB were inhibited by pre-incubating with recombinant LEDGF/p75, and eluted antibodies from the nitrocellulose membrane could react on the ELISA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 31-33 PC4 and SFRS1 interacting protein 1 Homo sapiens 90-99 19320460-0 2009 Interpretation of the binding affinities of PTP1B inhibitors with the MM-GB/SA method and the X-score scoring function. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 76-78 protein tyrosine phosphatase non-receptor type 1 Homo sapiens 44-49 19323449-2 2009 Here we study the effect of modifications of a p53 N-terminal fragment on its binding to MDM2, using implicit-solvent MD and MM-GB/SA calculations. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 131-133 tumor protein p53 Homo sapiens 47-50 19323449-2 2009 Here we study the effect of modifications of a p53 N-terminal fragment on its binding to MDM2, using implicit-solvent MD and MM-GB/SA calculations. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 131-133 MDM2 proto-oncogene Homo sapiens 89-93 19401579-4 2009 The SA method was significantly more efficient (mean processing time, 53 minutes vs 156 minutes for SA1 vs M1 and 53 minutes vs 118 minutes for SA2 vs M2; P < .001) and reproducible (mean volume overlap, 94.3% vs 87.8% for the SA method vs the M method; P < .001) than the M method. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 stromal antigen 2 Homo sapiens 144-147 18813811-0 2008 Reversal of P-glycoprotein-mediated multidrug resistance in human sarcoma MES-SA/Dx-5 cells by nonsteroidal anti-inflammatory drugs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 78-80 ATP binding cassette subfamily B member 1 Homo sapiens 12-26 19131332-2 2009 SABP2 is a methyl salicylate (MeSA) esterase that has high affinity for SA, which feedback inhibits its esterase activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 salicylic acid-binding protein 2 Nicotiana tabacum 11-44 19131332-4 2009 In this study, we examined the inhibitory interaction of SA with SABP2, and identified a synthetic SA analog, 2,2,2,2"-tetra-f luoroacetophenone (tetraFA) that, like SA, competitively inhibits the activity of SABP2 and targets esterases, which utilize MeSA as a substrate. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 57-59 salicylic acid-binding protein 2 Nicotiana tabacum 65-70 19302742-5 2009 RESULTS: In peripheral blood, the SA group had significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.01) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 chemokine (C-C motif) receptor 3 Mus musculus 67-71 19302742-5 2009 RESULTS: In peripheral blood, the SA group had significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.01) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 chemokine (C-C motif) receptor 5 Mus musculus 108-112 19302742-5 2009 RESULTS: In peripheral blood, the SA group had significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.01) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 chemokine (C-X-C motif) receptor 3 Mus musculus 117-122 19302742-5 2009 RESULTS: In peripheral blood, the SA group had significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.01) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 CD4 antigen Mus musculus 151-154 19302742-7 2009 In spleen, the SA group expressed significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.05) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 chemokine (C-C motif) receptor 3 Mus musculus 54-58 19302742-7 2009 In spleen, the SA group expressed significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.05) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 chemokine (C-C motif) receptor 5 Mus musculus 95-99 19302742-7 2009 In spleen, the SA group expressed significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.05) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 chemokine (C-X-C motif) receptor 3 Mus musculus 104-109 19302742-7 2009 In spleen, the SA group expressed significantly lower CCR3 expression (P < 0.01) and higher CCR5 and CXCR3 expression (P < 0.05) on CD4(+) T cells than did the NP group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 CD4 antigen Mus musculus 138-141 19302742-8 2009 When compared with the NNP group, the SA group had significantly higher CCR3 expression (P < 0.01), but was not statistically different with regards to the other two chemokines (P > 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 38-40 chemokine (C-C motif) receptor 3 Mus musculus 72-76 19302742-9 2009 In thymus, the SA group had significantly lower CCR3 expression (P < 0.05) and higher CXCR3 expression (P < 0.05) on CD4(+) T cells than the NP group, with no significant difference in CCR5 expression (P > 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 chemokine (C-C motif) receptor 3 Mus musculus 48-52 19302742-9 2009 In thymus, the SA group had significantly lower CCR3 expression (P < 0.05) and higher CXCR3 expression (P < 0.05) on CD4(+) T cells than the NP group, with no significant difference in CCR5 expression (P > 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 chemokine (C-X-C motif) receptor 3 Mus musculus 89-94 19302742-9 2009 In thymus, the SA group had significantly lower CCR3 expression (P < 0.05) and higher CXCR3 expression (P < 0.05) on CD4(+) T cells than the NP group, with no significant difference in CCR5 expression (P > 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 CD4 antigen Mus musculus 123-126 19302742-9 2009 In thymus, the SA group had significantly lower CCR3 expression (P < 0.05) and higher CXCR3 expression (P < 0.05) on CD4(+) T cells than the NP group, with no significant difference in CCR5 expression (P > 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 chemokine (C-C motif) receptor 5 Mus musculus 191-195 19302742-10 2009 Compared with the NNP group, the SA group had higher CCR3 expression (P < 0.01), but there was no statistical difference in CXCR3 and CCR5 expression (P > 0.05) between the two groups. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 chemokine (C-C motif) receptor 3 Mus musculus 53-57 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 tumor necrosis factor Homo sapiens 25-28 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 78-81 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 103-106 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 serum amyloid A1 cluster Homo sapiens 159-162 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 103-106 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 103-106 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 serum amyloid A1 cluster Homo sapiens 13-16 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 tumor necrosis factor Homo sapiens 25-28 18571179-10 2009 Importantly, SAA-induced TNF levels (ELISA) were much higher in patients with ACS than SA or controls (ACS 211+/-41, SA 108+/-16, controls 73+/-11 pg/mL, with SAA 250 ng/mL, P=0.001 ACS vs. controls or P=0.013 ACS vs. SA across the dose range). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 1-aminocyclopropane-1-carboxylate synthase homolog (inactive) Homo sapiens 78-81 19304509-6 2009 The purified hIL15-SA fusion protein exhibited a bifunctionality by promoting the proliferation of PBL cells activated by PHA and high-affinity binding to biotinylated cell surface mediated by SA, with a cell surface modification efficiency exceeding 95%. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 19-21 interleukin 15 Homo sapiens 13-18 18845169-7 2008 KB3-1 significantly enhanced the accumulation and retention of a P-gp substrate, rhodamine-123 in the P-gp-expressing MES-SA/DX5 uterine sarcoma cells but not in the P-gp-negative MES-SA cells at non-toxic concentrations of 1 microM and 3 microM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 122-124 ATP binding cassette subfamily B member 1 Homo sapiens 65-69 18845169-7 2008 KB3-1 significantly enhanced the accumulation and retention of a P-gp substrate, rhodamine-123 in the P-gp-expressing MES-SA/DX5 uterine sarcoma cells but not in the P-gp-negative MES-SA cells at non-toxic concentrations of 1 microM and 3 microM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 122-124 ATP binding cassette subfamily B member 1 Homo sapiens 102-106 18845169-7 2008 KB3-1 significantly enhanced the accumulation and retention of a P-gp substrate, rhodamine-123 in the P-gp-expressing MES-SA/DX5 uterine sarcoma cells but not in the P-gp-negative MES-SA cells at non-toxic concentrations of 1 microM and 3 microM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 122-124 ATP binding cassette subfamily B member 1 Homo sapiens 102-106 18727698-7 2008 We further demonstrated that adoptive transfer of CD4+CD25+ Treg cells, purified from CD28 SA-treated Lewis rats, significantly prolonged allograft survival and succeeded in inducing donor-specific tolerance. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 interleukin 2 receptor subunit alpha Homo sapiens 54-58 18727698-7 2008 We further demonstrated that adoptive transfer of CD4+CD25+ Treg cells, purified from CD28 SA-treated Lewis rats, significantly prolonged allograft survival and succeeded in inducing donor-specific tolerance. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 Cd28 molecule Rattus norvegicus 86-90 18727698-8 2008 In conclusion, CD28 SA treatment successfully induces donor-specific tolerance with the involvement of Treg cells, and thus the therapeutic value of this approach warrants further investigation and preclinical studies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 20-22 CD28 molecule Homo sapiens 15-19 18813811-8 2008 Our results demonstrate that Ibu, Cur and NS-398 below their therapeutic plasma concentrations were able to overcome P-gp-mediated MDR in MES-SA/Dx-5 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 142-144 ATP binding cassette subfamily B member 1 Homo sapiens 117-121 18088307-8 2008 Blocking SA accumulation in pmr4-1 restored basal resistance, but not BABA-IR against A. brassicicola. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 glucan synthase-like 5 Arabidopsis thaliana 28-32 18638486-5 2008 The Phe34 phenyl side chain situated at the tip of the relatively short sA-sB loop of TIMP-3 extends into a unique hydrophobic groove of the TACE surface, and two Leu residues in the adjacent sC-connector and sE-sF loops are tightly packed in the interface allowing favourable interactions, in agreement with predictions obtained by systematic mutations by Gillian Murphy"s group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 TIMP metallopeptidase inhibitor 3 Homo sapiens 86-92 18638486-5 2008 The Phe34 phenyl side chain situated at the tip of the relatively short sA-sB loop of TIMP-3 extends into a unique hydrophobic groove of the TACE surface, and two Leu residues in the adjacent sC-connector and sE-sF loops are tightly packed in the interface allowing favourable interactions, in agreement with predictions obtained by systematic mutations by Gillian Murphy"s group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 ADAM metallopeptidase domain 17 Homo sapiens 141-145 18625294-1 2008 The role of multi-drug resistance (MDR1) and its product, P-glycoprotein (P-gp) on 5-aminolevulinic acid hexyl ester (Hexyl-ALA) mediated phototoxicity was determined with human uterine sarcoma cells, MES-SA control and MDR1 expressing MES-SA-Dx5. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 205-207 ATP binding cassette subfamily B member 1 Homo sapiens 35-39 18625294-1 2008 The role of multi-drug resistance (MDR1) and its product, P-glycoprotein (P-gp) on 5-aminolevulinic acid hexyl ester (Hexyl-ALA) mediated phototoxicity was determined with human uterine sarcoma cells, MES-SA control and MDR1 expressing MES-SA-Dx5. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 205-207 ATP binding cassette subfamily B member 1 Homo sapiens 74-78 18207448-5 2008 The salient finding was that expression of syndecan-1 was related to the histological subtype of tumors, as there was a lower expression in SA (40.2%) as compared to UA (49.7%) (p<0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 140-142 syndecan 1 Homo sapiens 43-53 17706812-5 2008 MMP-9 (P=0.011), but not TIMP-1, expression was higher in debris samples from patients in the ACS-Group than in SA-Group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 112-114 matrix metallopeptidase 9 Homo sapiens 0-5 17706812-7 2008 Zymography data indicated that pro and active MMP-9 were higher in ACS than in SA-Group, while no difference in MMP-2 was found. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 79-81 matrix metallopeptidase 9 Homo sapiens 46-51 18645019-9 2008 Both drugs block anchorage-independent growth in high-grade human uterine cancer cells that overexpress HMGA1a (MES-SA cells). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 116-118 high mobility group AT-hook 1 Homo sapiens 104-110 17351819-8 2008 GhAOX1 was also found to be induced by a variety of stresses stimulation including cold, citrate, SA, KCN and antimycin A in cotton. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 98-100 ubiquinol oxidase 2, mitochondrial-like Gossypium hirsutum 0-6 18358458-10 2008 SA administration to leukemic animals resulted in clearance of the leukemic cells from the bone marrow and internal organs on histopathological examination and this was confirmed by RT-PCR for the p210 mRNA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 envoplakin Mus musculus 197-201 18439041-9 2008 Likewise, SOD2 activity was elevated in SA-NH mouse sarcoma cells 7.8- and 4.9-fold after daily exposure to WR1065 or exposure to WR1065 once every 48 h, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 superoxide dismutase 2, mitochondrial Mus musculus 10-14 17804168-6 2008 Results showed that SA pretreatment significantly increased expression of HSP70 in the small intestine. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 20-22 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 74-79 17804168-8 2008 Co-administration of quercetin with SA abolished the SA-induced HSP70 over-expression and the beneficial effects of SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 64-69 17804168-8 2008 Co-administration of quercetin with SA abolished the SA-induced HSP70 over-expression and the beneficial effects of SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 53-55 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 64-69 17804168-8 2008 Co-administration of quercetin with SA abolished the SA-induced HSP70 over-expression and the beneficial effects of SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 53-55 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 64-69 17804168-9 2008 Our findings suggest increasing expression of HSP70 induced by SA pretreatment attenuates burn-induced intestinal injury apparently by preventing apoptosis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 63-65 heat shock protein family A (Hsp70) member 1B Rattus norvegicus 46-51 19099974-6 2008 RESULT: The proportions of mDC precursors were significantly lower in UA group and AMI group (4.7% +/- 2.6%, 5.0% +/- 2.7%) than that in SA, CPS and control groups (11.0% +/- 6.4%, 12.0% +/- 3.9%, 12.3% +/- 3.3%, respectively, all P < 0.001). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 137-139 chemokine (C-C motif) ligand 22 Mus musculus 27-30 18270854-8 2008 The anti-Sa antibody has been identified a decade ago; however, recent studies confirmed that anti-Sa is directed against citrullinated vimentin, hence it is a new member of the family of ACPAs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 vimentin Homo sapiens 136-144 18479026-10 2008 The binding constants and sites of the interaction with SA were analyzed by the Scatchard"s equation, the results indicated that there was a strong interaction between the four metal complexes and serum albumin and the binding force was Co-GLUS > Zn-GLUS > Cu-GLUS > Cu-GLUS, and the binding site is only one. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 albumin Bos taurus 203-210 17929052-12 2008 SA-induced expression of AtPR1 and AtGST1, also was delayed in CaGLIP1-overexpressing plants by SA application. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 pathogenesis-related protein 1 Arabidopsis thaliana 25-30 17929052-12 2008 SA-induced expression of AtPR1 and AtGST1, also was delayed in CaGLIP1-overexpressing plants by SA application. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 glutathione S-transferase 6 Arabidopsis thaliana 35-41 17929052-12 2008 SA-induced expression of AtPR1 and AtGST1, also was delayed in CaGLIP1-overexpressing plants by SA application. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 96-98 pathogenesis-related protein 1 Arabidopsis thaliana 25-30 17929052-12 2008 SA-induced expression of AtPR1 and AtGST1, also was delayed in CaGLIP1-overexpressing plants by SA application. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 96-98 glutathione S-transferase 6 Arabidopsis thaliana 35-41 18535297-8 2008 ABA-responsive TFs were more induced in NOJ compared with SUL, including WRKY1, mediating a response in SA signalling that may give rise to increased ROS. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 104-106 probable WRKY transcription factor 75-like Solanum tuberosum 73-78 18163519-1 2008 OBJECTIVE: The Sa autoantigen can be found in inflamed synovium of patients with rheumatoid arthritis (RA), and at least part of the humoral RA-specific anti-Sa response is directed against citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 vimentin Homo sapiens 204-212 18052881-3 2008 By contrast, both RAR1 and SGT1b are required in a genetically additive manner for ssi4-induced disease resistance, SA accumulation, and lesion formation after pathogen infection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 116-118 cysteine and histidine-rich domain-containing protein RAR1 Arabidopsis thaliana 18-22 18052881-3 2008 By contrast, both RAR1 and SGT1b are required in a genetically additive manner for ssi4-induced disease resistance, SA accumulation, and lesion formation after pathogen infection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 116-118 phosphatase-like protein Arabidopsis thaliana 27-32 17205127-8 2006 Analysis of marker gene expression using these HIFs indicated a negative correlation between the induced amount of transcripts of SA-dependent genes PR1, ICS and PR5, and the in planta bacterial growth in the HIF segregating at PRP-Ps2 locus, suggesting an implication of PRP-Ps2 in the activation of SA dependent responses. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 pathogenesis-related protein 1 Arabidopsis thaliana 149-152 18050095-6 2007 Regarding SA-SIP30 categories, floor effect ranged from 15.2% (social interaction) to 49.4% (alertness behavior), whereas ceiling effect ranged from 2.5% (social interaction) to 26.6% (household management). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 ZW10 interacting kinetochore protein Homo sapiens 13-18 17916362-9 2007 Conversely, overexpression of Sirt1 prevented hydrogen peroxide-induced SA-beta-gal activity, morphological changes and deranged expression of PAI-1 and eNOS. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 sirtuin 1 Homo sapiens 30-35 17804819-6 2007 In addition, treatment with IGFBP-5 protein or up-regulation of IGFBP-5 in young cells accelerates cellular senescence, as confirmed by cell proliferation and SA-beta-gal staining. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 159-161 insulin like growth factor binding protein 5 Homo sapiens 28-35 17804819-6 2007 In addition, treatment with IGFBP-5 protein or up-regulation of IGFBP-5 in young cells accelerates cellular senescence, as confirmed by cell proliferation and SA-beta-gal staining. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 159-161 insulin like growth factor binding protein 5 Homo sapiens 64-71 17692467-0 2007 Distinct N-glycan glycosylation of P-glycoprotein isolated from the human uterine sarcoma cell line MES-SA/Dx5. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 104-106 ATP binding cassette subfamily B member 1 Homo sapiens 35-49 17545035-5 2007 RESULTS: The proportions of CD4(+)CD25(+) Treg were significantly lower in UA group (6.55-/+2.45%) than in SA (14.01-/+4.92%) and control groups (13.55-/+3.87%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 CD4 molecule Homo sapiens 28-31 17545035-6 2007 The proportions of CD4(+)CD28(-) T cells were significantly higher in UA group (10.55-/+4.76%) than in SA (2.64-/+1.33%) and control (2.75-/+1.55%) groups. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 103-105 CD4 molecule Homo sapiens 19-22 16896994-2 2007 Allelic variants of the NAT2 gene are determined by a pattern of single nucleotide polymorphisms (SNPs) resulting in slow (SA), intermediate (IA) or rapid acetylator (RA) phenotypes and causing the individual differences in the NAT2 metabolic capacity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 123-125 N-acetyltransferase 2 Homo sapiens 24-28 17202657-2 2007 The present study was conducted to examine protective effect of SA on liver injury induced by carbon tetrachloride (CCl4) and its possible mechanism in vivo. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 C-C motif chemokine ligand 4 Rattus norvegicus 116-120 17202657-8 2007 SA reversed the significant changes induced by CCl4. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 C-C motif chemokine ligand 4 Rattus norvegicus 47-51 17202657-9 2007 These results demonstrate that SA produces protective action on acute hepatic injury induced by CCl4 via an antioxidative mechanism. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 31-33 C-C motif chemokine ligand 4 Rattus norvegicus 96-100 17700709-6 2007 We showed that after intrasplenic immunization with T/SA-OVA cells, splenic class I(+) class II(+) CD11c(+) cells engulfed and presented in vivo the OVA class I-restricted peptide SIINFEKL. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 54-56 integrin subunit alpha X Homo sapiens 99-104 19090118-9 2007 Concentrations of 0.7, 1.5 ad 3 mM of SA decreased in (catalase, ascorbate peroxidase and glutathione reductase) activities, but concentrations of 6 and 9 Mm of SA increased enzyme activities. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 38-40 catalase Capsicum annuum 55-63 19090118-9 2007 Concentrations of 0.7, 1.5 ad 3 mM of SA decreased in (catalase, ascorbate peroxidase and glutathione reductase) activities, but concentrations of 6 and 9 Mm of SA increased enzyme activities. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 38-40 glutathione reductase, chloroplastic Capsicum annuum 90-111 19704670-3 2007 In our recent paper to which we write this Addendum, we show that loss of SIZ1, a SUMO E3 ligase, results in a highly increased SA-mediated defense signaling through a PAD4-dependent pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 128-130 peptidyl arginine deiminase 4 Homo sapiens 168-172 18637469-2 2007 Examples of reactions of mAb and eluted allosera with the class I, class II and MICA SA are also presented. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 MHC class I polypeptide-related sequence A Homo sapiens 80-84 17541908-9 2007 DQB1*02, DQA1*0501 (Ls) and DRB1*15 (Stage II) were more frequently present in SA than in TB, even after Bonferroni correction. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 79-81 major histocompatibility complex, class II, DQ beta 1 Homo sapiens 0-4 17541908-9 2007 DQB1*02, DQA1*0501 (Ls) and DRB1*15 (Stage II) were more frequently present in SA than in TB, even after Bonferroni correction. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 79-81 major histocompatibility complex, class II, DQ alpha 1 Homo sapiens 9-13 17541908-9 2007 DQB1*02, DQA1*0501 (Ls) and DRB1*15 (Stage II) were more frequently present in SA than in TB, even after Bonferroni correction. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 79-81 major histocompatibility complex, class II, DR beta 1 Homo sapiens 28-32 17109639-8 2006 Because ErbB1 or ErbB2 receptors form heterodimers with the ErbB3 receptor, and ErbB3 heterodimers have been shown to be the most potent activators of PI3K, these findings strongly suggest that the antiproliferative effects of gamma-tocotrienol in neoplastic +SA mouse mammary epithelial cells are mediated by a suppression in ErbB3-receptor tyrosine phosphorylation and subsequent reduction in PI3K/PDK-1/Akt mitogenic signalling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 260-262 erb-b2 receptor tyrosine kinase 2 Mus musculus 17-22 17109639-8 2006 Because ErbB1 or ErbB2 receptors form heterodimers with the ErbB3 receptor, and ErbB3 heterodimers have been shown to be the most potent activators of PI3K, these findings strongly suggest that the antiproliferative effects of gamma-tocotrienol in neoplastic +SA mouse mammary epithelial cells are mediated by a suppression in ErbB3-receptor tyrosine phosphorylation and subsequent reduction in PI3K/PDK-1/Akt mitogenic signalling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 260-262 erb-b2 receptor tyrosine kinase 3 Mus musculus 80-85 17109639-8 2006 Because ErbB1 or ErbB2 receptors form heterodimers with the ErbB3 receptor, and ErbB3 heterodimers have been shown to be the most potent activators of PI3K, these findings strongly suggest that the antiproliferative effects of gamma-tocotrienol in neoplastic +SA mouse mammary epithelial cells are mediated by a suppression in ErbB3-receptor tyrosine phosphorylation and subsequent reduction in PI3K/PDK-1/Akt mitogenic signalling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 260-262 erb-b2 receptor tyrosine kinase 3 Mus musculus 80-85 17030602-7 2006 Overexpression of beta-catenin (SA), which cannot be phosphorylated by GSK-3beta and targeted for ubiquitination, significantly increased migration in fully confluent cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 catenin beta 1 Homo sapiens 18-30 17030602-7 2006 Overexpression of beta-catenin (SA), which cannot be phosphorylated by GSK-3beta and targeted for ubiquitination, significantly increased migration in fully confluent cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 glycogen synthase kinase 3 beta Homo sapiens 71-80 16832635-11 2006 After injection of (111)In-DTPA-15D3, the high P-gp expressing MES-SA/Dx5 1977 tumours were clearly visualised at 3 days p.i. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 67-69 phosphoglycolate phosphatase Mus musculus 47-51 16832635-12 2006 The biodistribution data indicated that radioactivity concentration in the high P-gp expressing tumours was higher than in the tumours with low P-gp expression (20.78+/-1.42 %ID/g for MES-SA/Dx5 1977 tumours and 8.39+/-3.78 %ID/g for MES-SA 1976 tumours for (111)In-DTPA-15D3). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 188-190 phosphoglycolate phosphatase Mus musculus 80-84 17205127-8 2006 Analysis of marker gene expression using these HIFs indicated a negative correlation between the induced amount of transcripts of SA-dependent genes PR1, ICS and PR5, and the in planta bacterial growth in the HIF segregating at PRP-Ps2 locus, suggesting an implication of PRP-Ps2 in the activation of SA dependent responses. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 pathogenesis-related protein 5 Arabidopsis thaliana 162-165 17205127-8 2006 Analysis of marker gene expression using these HIFs indicated a negative correlation between the induced amount of transcripts of SA-dependent genes PR1, ICS and PR5, and the in planta bacterial growth in the HIF segregating at PRP-Ps2 locus, suggesting an implication of PRP-Ps2 in the activation of SA dependent responses. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 301-303 pathogenesis-related protein 1 Arabidopsis thaliana 149-152 17205127-8 2006 Analysis of marker gene expression using these HIFs indicated a negative correlation between the induced amount of transcripts of SA-dependent genes PR1, ICS and PR5, and the in planta bacterial growth in the HIF segregating at PRP-Ps2 locus, suggesting an implication of PRP-Ps2 in the activation of SA dependent responses. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 301-303 pathogenesis-related protein 5 Arabidopsis thaliana 162-165 17229373-7 2006 RESULTS: Sa, Ea and Ea/Aa were the lowest in children < 1 month of age [MA-L: Sa (4.8 +/- 0.7) cm/s, Ea (6.6 +/- 1.1) cm/s; MA-S: Sa (4.1 +/- 0.6) cm/s, Ea (5.0 +/- 0.8) cm/s; TA: Sa (6.2 +/- 1.2) cm/s, Ea (6.4 +/- 1.0) cm/s], and increased with age. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 mal, T cell differentiation protein Homo sapiens 75-79 17229373-7 2006 RESULTS: Sa, Ea and Ea/Aa were the lowest in children < 1 month of age [MA-L: Sa (4.8 +/- 0.7) cm/s, Ea (6.6 +/- 1.1) cm/s; MA-S: Sa (4.1 +/- 0.6) cm/s, Ea (5.0 +/- 0.8) cm/s; TA: Sa (6.2 +/- 1.2) cm/s, Ea (6.4 +/- 1.0) cm/s], and increased with age. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 mal, T cell differentiation protein Homo sapiens 75-79 17229373-8 2006 The increase was significant from 1 month- to 1 year-of age group 1 year-of age group: MA-L: Sa (8.5 +/- 2.0) cm/s, Ea (16.3 +/- 2.6) cm/s; MA-S: Sa (7.2 +/- 0.8) cm/s, Ea (12.2 +/- 1.6) cm/s; TA: Sa (12.6 +/- 2.3) cm/s, Ea (14.7 +/- 2.6) cm/s. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 93-95 mal, T cell differentiation protein Homo sapiens 87-91 17229373-8 2006 The increase was significant from 1 month- to 1 year-of age group 1 year-of age group: MA-L: Sa (8.5 +/- 2.0) cm/s, Ea (16.3 +/- 2.6) cm/s; MA-S: Sa (7.2 +/- 0.8) cm/s, Ea (12.2 +/- 1.6) cm/s; TA: Sa (12.6 +/- 2.3) cm/s, Ea (14.7 +/- 2.6) cm/s. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 146-148 mal, T cell differentiation protein Homo sapiens 87-91 17072036-8 2006 We found that the SA patients had the highest level of ET-1 (SA - 11.4 +/-3.6 fmol/ml; AA - 7.1 +/-2.7 fmol/ml; C - 5.6 +/-1.8 fmol/ml) in BALF. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 endothelin 1 Homo sapiens 55-59 16337339-2 2006 The individual differences in the NAT2 metabolic capacity are caused by allelic variants of the NAT2 gene which are determined by a pattern of single nucleotide polymorphisms (SNPs) resulting in slow (SA), intermediate (IA) or rapid acetylator (RA) phenotypes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 201-203 N-acetyltransferase 2 Homo sapiens 34-38 16337339-2 2006 The individual differences in the NAT2 metabolic capacity are caused by allelic variants of the NAT2 gene which are determined by a pattern of single nucleotide polymorphisms (SNPs) resulting in slow (SA), intermediate (IA) or rapid acetylator (RA) phenotypes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 201-203 N-acetyltransferase 2 Homo sapiens 96-100 16741000-11 2006 Plasma ET-1 concentration was significantly higher in SA compared with EA and SC (1.64 vs. 1.12 vs. 1.24 pg/ml, P < 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 54-56 endothelin 1 Homo sapiens 7-11 16838311-0 2006 A computational analysis of the binding affinities of FKBP12 inhibitors using the MM-PB/SA method. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 88-90 FKBP prolyl isomerase 1A pseudogene 4 Homo sapiens 54-60 16964757-4 2006 Compound 1 showed the most potent P-gp MDR inhibition activity with an ED50 value 0.03 microg/mL and 0.00010 microg/mL in the MES-SA/DX5 and HCT15 cells, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 130-132 phosphoglycolate phosphatase Homo sapiens 34-38 17064527-13 2006 CONCLUSION: Citrullinated vimentin is closely correlated with Sa antigen. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 vimentin Homo sapiens 26-34 16458937-7 2006 These results suggest that up-regulation of eNOS in response to cyclic stretch was mediated by two distinct pathways, [Ca(2+)](i) increases via the SA channel in an early phase (partially Akt/PKB), and PI3K-Akt/PKB pathways in a late phase. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 148-150 nitric oxide synthase 3 Bos taurus 44-48 16458937-7 2006 These results suggest that up-regulation of eNOS in response to cyclic stretch was mediated by two distinct pathways, [Ca(2+)](i) increases via the SA channel in an early phase (partially Akt/PKB), and PI3K-Akt/PKB pathways in a late phase. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 148-150 AKT serine/threonine kinase 1 Bos taurus 188-191 16458937-7 2006 These results suggest that up-regulation of eNOS in response to cyclic stretch was mediated by two distinct pathways, [Ca(2+)](i) increases via the SA channel in an early phase (partially Akt/PKB), and PI3K-Akt/PKB pathways in a late phase. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 148-150 AKT serine/threonine kinase 1 Bos taurus 192-195 16629790-8 2006 Levels of SP-B and SP-C in asthmatics correlated with the ratio of small to large surfactant aggregates (SA/LA ratio) and correlated negatively with BAL surface activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 105-107 surfactant protein B Homo sapiens 10-14 16629790-8 2006 Levels of SP-B and SP-C in asthmatics correlated with the ratio of small to large surfactant aggregates (SA/LA ratio) and correlated negatively with BAL surface activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 105-107 surfactant protein C Homo sapiens 19-23 16650666-13 2006 Pooling the data from post-PRK and control eyes, a significant correlation was found between near acuity and SA (right eyes, r = -0.535, P = 0.015; left eyes, r = -0.493, P = 0.027). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 109-111 polo like kinase 3 Homo sapiens 27-30 16635388-9 2006 HSP72 was expressed in SA group but not in control group and oppositely NF-kappaB was expressed in control group but not in DXR group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 23-25 heat shock protein family A (Hsp70) member 1A Rattus norvegicus 0-5 16513099-9 2006 Protective effect of SA was also observed by the decrease in the levels and expression of tumour necrosis factor alpha (TNF-alpha) as well as the histopathological and radiological observations. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 21-23 tumor necrosis factor Rattus norvegicus 120-129 17195622-3 2006 Clinical trials have recently shown the impressive efficacy of two anti-TNFalpha agents (infliximab and etanercept) in patients with NSAID-resistant SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 134-136 tumor necrosis factor Homo sapiens 72-80 16524605-1 2006 An anionic potato peroxidase (EC 1.11.1.7, APP) thought to be involved in suberization after wounding was isolated from slices of Solanum tuberosum in order to elucidate the first steps of dehydrogenative polymerization between pairs of different hydroxycinnamic acids (FA, CafA, CA and SA) present in wound-healing plant tissues. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 287-289 peroxidase N1 Solanum tuberosum 18-28 16275897-4 2006 N-acetylcysteine, a scavenger of reactive oxygen species (ROS), effectively inhibited the activation of p38 and cellular death, indicating that the activation induced by ROS is an initial step in the process of apoptosis triggered by SA-liposomes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 234-236 mitogen-activated protein kinase 14 Mus musculus 104-107 16275897-7 2006 Taken together, our results suggest that apoptosis of RAW264.7 by SA-liposomes was mediated by the MAPK p38 and a caspase-8-dependent Bid-cleavage pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 66-68 mitogen-activated protein kinase 14 Mus musculus 104-107 16275897-7 2006 Taken together, our results suggest that apoptosis of RAW264.7 by SA-liposomes was mediated by the MAPK p38 and a caspase-8-dependent Bid-cleavage pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 66-68 caspase 8 Mus musculus 114-123 16275897-7 2006 Taken together, our results suggest that apoptosis of RAW264.7 by SA-liposomes was mediated by the MAPK p38 and a caspase-8-dependent Bid-cleavage pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 66-68 BH3 interacting domain death agonist Mus musculus 134-137 16332129-12 2005 NaSA increased atrazine activity on npr1-2, an Arabidopsis mutant compromised in SA-induced disease resistance. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 2-4 regulatory protein (NPR1) Arabidopsis thaliana 36-42 16190382-6 2005 The plasma vWF level of the SA group were higher than that of the UA group (P = 0.012). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 28-30 von Willebrand factor Homo sapiens 11-14 16245273-5 2005 To overcome this drawback, INU-MA1 was derivatized with SA thus obtaining the INU-MA1-SA derivative designed to produce a hydrogel showing a low swelling and an increased chemical stability in acidic medium. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 PNMA family member 1 Homo sapiens 31-34 16245273-5 2005 To overcome this drawback, INU-MA1 was derivatized with SA thus obtaining the INU-MA1-SA derivative designed to produce a hydrogel showing a low swelling and an increased chemical stability in acidic medium. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 PNMA family member 1 Homo sapiens 82-85 16040169-5 2005 Diarrhea in SA-11 rotavirus challenged neonates suckling from STB::NSP4 immunized dams was significantly reduced in severity and duration in comparison with virus challenged neonates from unimmunized mice. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 12-14 protease, serine 57 Mus musculus 67-71 16230402-3 2005 In this study, we answer these fundamental questions through investigation of the genetic and epigenetic pathways that control the origin of ABCB1 (MDR1) gene activation with acquired multidrug resistance in drug-sensitive human sarcoma (MES-SA cells). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 242-244 ATP binding cassette subfamily B member 1 Homo sapiens 141-146 16230402-3 2005 In this study, we answer these fundamental questions through investigation of the genetic and epigenetic pathways that control the origin of ABCB1 (MDR1) gene activation with acquired multidrug resistance in drug-sensitive human sarcoma (MES-SA cells). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 242-244 ATP binding cassette subfamily B member 1 Homo sapiens 148-152 16230402-8 2005 Thus, our data provide evidence for a major genomic alteration that changes the chromatin structure of the ABCB1 upstream promoter via acetylation of histone H3 initiating ABCB1 activation, further elucidating the genetic and epigenetic bases that determine chemotherapeutic response in drug-resistant derivatives of MES-SA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 321-323 ATP binding cassette subfamily B member 1 Homo sapiens 107-112 16230402-8 2005 Thus, our data provide evidence for a major genomic alteration that changes the chromatin structure of the ABCB1 upstream promoter via acetylation of histone H3 initiating ABCB1 activation, further elucidating the genetic and epigenetic bases that determine chemotherapeutic response in drug-resistant derivatives of MES-SA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 321-323 ATP binding cassette subfamily B member 1 Homo sapiens 172-177 16275897-3 2006 Treatment with SA-liposomes caused the activation of mitogen-activated protein kinases (MAPKs), especially p38 and c-jun N-terminal kinase, and apoptosis was only inhibited upon the addition of a specific inhibitor for p38. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 mitogen-activated protein kinase 14 Mus musculus 107-110 16275897-3 2006 Treatment with SA-liposomes caused the activation of mitogen-activated protein kinases (MAPKs), especially p38 and c-jun N-terminal kinase, and apoptosis was only inhibited upon the addition of a specific inhibitor for p38. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 mitogen-activated protein kinase 14 Mus musculus 219-222 15983010-0 2005 Overexpression of SIPK in tobacco enhances ozone-induced ethylene formation and blocks ozone-induced SA accumulation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 101-103 mitogen-activated protein kinase homolog NTF4-like Nicotiana tabacum 18-22 15904640-12 2005 There were significant correlations between the increment in BNP and changes in Sa and peak dP/dt values (r = -0.67 and -0.53, p <0.01, respectively), and the severity of PR (r = 0.74, p <0.01). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 80-82 natriuretic peptide B Homo sapiens 61-64 15746970-4 2005 Exposure for 24 h to 0-20 micromol/L gamma-tocotrienol resulted in a dose-responsive increase in +SA cells undergoing apoptosis, as determined by flow cytometric analysis of Annexin V staining. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 98-100 annexin A5 Homo sapiens 174-183 15983172-5 2005 When compared with the control cells, WI-38 cells transfected with hNaDC3 cDNA showed significant suppression of growth rate (by 40%), increase of positive rate of SA-beta-gal staining, decrease of mitochondrial membrane potential, shortening of telomere length, and increase of P16 and P21 expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 164-166 solute carrier family 13 member 3 Homo sapiens 67-73 15820444-10 2005 The increment in CRP level and ESR observed in arthritic animals were found to be significantly restored in SA treated rats. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 108-110 C-reactive protein Rattus norvegicus 17-20 15721393-4 2005 After an appropriate formulation of SOD in SA-liposomes, the therapeutic effect is strongly increased, as indicated by a reduction of about 40% of inflammation edema compared with treatment with nonencapsulated enzyme. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 43-45 superoxide dismutase 1 Homo sapiens 36-39 15701871-6 2005 After TES restoration by Ad-TES transduction, T47D and MES-SA cell lines underwent apoptosis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 59-61 testin LIM domain protein Homo sapiens 6-9 15701871-6 2005 After TES restoration by Ad-TES transduction, T47D and MES-SA cell lines underwent apoptosis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 59-61 testin LIM domain protein Homo sapiens 28-31 15542325-3 2004 Then, in order to examine copper-ion distribution structure in the NIPA/SA gel dehydrated after absorption of copper-ion, an incident-X-ray energy-dependence of a small-angle X-ray scattering profile was observed, in which the anomalous dispersion effect was clearly perceived especially around a distinct SAXS-peak. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 72-74 zinc finger C3HC-type containing 1 Homo sapiens 67-71 15542325-4 2004 Because the SAXS-peak is thought to come from a dehydration-induced microphase separation between hydrophilic and hydrophobic network-polymers in the NIPA/SA gel, such a feature indicates that the copper-ions gather in the dehydration-induced hydrophilic domains. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 12-14 zinc finger C3HC-type containing 1 Homo sapiens 150-154 15876151-6 2005 We find out that SA-beta-Gal staining is detectable in irradiated ARO xenotransplants, but not in control tumors. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 cytochrome P450 family 19 subfamily A member 1 Homo sapiens 66-69 15516746-2 2004 Over the acidic pH range, the coordination of Cr(III) ion to SA and its derivatives in 1 : 1 mole ratio occurs, CrL(+) type complex is formed. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 61-63 interleukin 31 receptor A Homo sapiens 112-115 15516746-8 2004 The stabilities of SA complexes for V(IV), Cr(III) and Fe(III) ions that have similar ionic radii, increase in the order VOL<CrL(+)<FeL(+). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 19-21 interleukin 31 receptor A Homo sapiens 128-131 15024070-7 2004 Inhibition of CDK5 attenuates SA-beta-Gal expression and blocks actin polymerization. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 cyclin dependent kinase 5 Homo sapiens 14-18 15333929-0 2004 A redetermination of the structure of the triple mutant (K53,56,120M) of phospholipase A2 at 1.6 A resolution using sulfur-SAS at 1.54 A wavelength. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 123-126 LOC104974671 Bos taurus 73-89 14600834-9 2004 We found that the wound-induced expression of gammaVPE was reduced in two SA-deficient plants (pad4-1 and NahG), while the wound-induced expression of VSP increased in these mutants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 74-76 gamma vacuolar processing enzyme Arabidopsis thaliana 46-54 15077630-6 2004 Pre-treatment with 500 micromol/L SA for 24 h in the dark before Pq application increased the activities of the studied enzymes in both the chloroplasts (SOD activity) and the other compartments of the cell (POX, CAT activity). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 prx7 Hordeum vulgare 208-211 15077630-7 2004 The effect of SA pre-treatment was highly expressed on DHAR and POX activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 prx7 Hordeum vulgare 64-67 14742681-3 2004 SA 96, and particularly its metabolite SA 981, increased the levels of vascular endothelial growth factor (VEGF) mRNA and protein dose-dependently in dermal fibroblasts from patients with SSc and healthy control subjects without influencing cell viability. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 vascular endothelial growth factor A Homo sapiens 71-105 14742681-3 2004 SA 96, and particularly its metabolite SA 981, increased the levels of vascular endothelial growth factor (VEGF) mRNA and protein dose-dependently in dermal fibroblasts from patients with SSc and healthy control subjects without influencing cell viability. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 vascular endothelial growth factor A Homo sapiens 107-111 14742681-3 2004 SA 96, and particularly its metabolite SA 981, increased the levels of vascular endothelial growth factor (VEGF) mRNA and protein dose-dependently in dermal fibroblasts from patients with SSc and healthy control subjects without influencing cell viability. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 39-41 vascular endothelial growth factor A Homo sapiens 71-105 14742681-3 2004 SA 96, and particularly its metabolite SA 981, increased the levels of vascular endothelial growth factor (VEGF) mRNA and protein dose-dependently in dermal fibroblasts from patients with SSc and healthy control subjects without influencing cell viability. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 39-41 vascular endothelial growth factor A Homo sapiens 107-111 15059270-3 2004 It has recently been confirmed that anti-Sa antibodies are directed to citrullinated vimentin, thus placing them in the anti-citrulline family of autoantibodies. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 41-43 vimentin Homo sapiens 85-93 15059278-8 2004 Since antibodies to citrullinated proteins are known to be highly specific for RA, we investigated whether Sa is citrullinated and found that Sa indeed is citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 vimentin Homo sapiens 169-177 15059278-8 2004 Since antibodies to citrullinated proteins are known to be highly specific for RA, we investigated whether Sa is citrullinated and found that Sa indeed is citrullinated vimentin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 142-144 vimentin Homo sapiens 169-177 14600834-11 2004 These results suggest that endogenous SA enhances the wound-induced expression of gammaVPE and attenuates the wound-induced expression of VSP, although SA is not a wound-signal that directly activates these genes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 38-40 gamma vacuolar processing enzyme Arabidopsis thaliana 82-90 14617775-3 2003 We find that when using GB/SA: (i) A21 is predicted to be more helical than the Fs peptide at all temperatures; (ii) the native structure of the Fs peptide is predicted to be a helical bundle instead of a single helix; and (iii) the persistence length and most probable end-to-end distance are too large in the unfolded state when compared against the explicit solvent simulations. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 27-29 immunoglobulin kappa variable 2-26 (pseudogene) Homo sapiens 35-38 14529723-4 2003 After proteolytic cleavage of native SNAP-25 by botulinum neurotoxin E (BoNT/E), synaptic transmission was restored in a subset of transfected CA3 pyramidal cells with a toxin-resistant form of SNAP-25 containing unaltered S187 (Swt), S187 mutated to alanine (SA) or S187 mutated to glutamate (SE). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 260-262 synaptosome associated protein 25 Homo sapiens 37-44 14679790-6 2003 Moreover, we found that the serum TRX levels in patients with ACS were significantly higher than in SA, whereas no significant difference was found between patients with SA and control subjects. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 100-102 thioredoxin Homo sapiens 34-37 14580871-10 2003 With regard to the in vivo situation, in addition to cellular senescence, TGF-beta could contribute to the increased number of SA-beta-gal positive epithelial cells in BPH. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 127-129 transforming growth factor beta 1 Homo sapiens 74-82 12647051-4 2003 Southern-blot analysis indicated that there were several KR1-related sequences within the soybean genome, and two polymorphic loci were mapped onto linkage group L. KR1 was induced by SA treatment and soybean mosaic virus (SMV) infection in the resistant line (Kefeng 1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 184-186 resistance protein KR1 Glycine max 165-168 12928897-9 2003 Given that excessive chromosomal losses may confer a disadvantage for tumor growth or a benefit for a metaplastic transformation, these results suggest that the multidirectional differentiation of a SCC precursor is stimulated by extensive and divergent LOHs acquired at the initial or early stages, and a precursor burdened with excessive LOH either remains in CIS or expands as a SA component. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 382-384 serpin family B member 3 Homo sapiens 199-202 12842760-6 2003 In THP-1 cells, pretreatment with PTx, PP2 and LY 294002 inhibited TNFalpha production induced by LPS (84+/-3%, 59+/-12% and 84+/-4% inhibition, n=3, p<0.05, respectively) and SA (56+/-7%, 87+/-1% and 35+/-6% inhibition, n=3, p<0.05, respectively). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 179-181 toll-like receptor 4 Mus musculus 98-101 12853972-7 2003 AraC was able to induce protein phosphatases (PP) 2A and 2B-A, and phosphorylation of p65 subunit of NF-kappaB in the HuT-78 and SA-LPS/Jkt cells was downregulated by araC treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 129-131 RELA proto-oncogene, NF-kB subunit Homo sapiens 86-110 12767280-4 2003 The most potent compound toward human CYP 17 (testicular microsomes) was Sa 40 (IC(50) value of 24 nM), followed by Sa 41, CB 7598, BW 19, CB 7630 and ketoconazole. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 73-75 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 38-44 12767280-6 2003 No recovery of enzyme activity was observed after preincubation of CYP 17 with Sa 40 and subsequent charcoal treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 79-81 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 67-73 12767280-7 2003 In Escherichia coli cells coexpressing human CYP 17 and NADPH-P450 reductase, Sa 40 was more active than CB 7598 and BW 19, whereas the acetyl compounds were not active. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 78-80 cytochrome P450 family 17 subfamily A member 1 Homo sapiens 45-51 12640658-8 2003 By quantitative assay, SA-beta gal activity is correlated with both tissue levels of Il-1alpha and the severity of BPH. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 23-25 interleukin 1 alpha Homo sapiens 85-94 12728993-8 2003 Thus, NCI activates SAR, independently from ethylene and jasmonic acid, by stimulating the site between SA and NPR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 20-22 regulatory protein (NPR1) Arabidopsis thaliana 111-115 12778761-6 2003 RESULTS: SA liposome-mediated bFGF expressed at a high level in the cochlea of guinea pigs, and in the rescue group, a significant lower hearing thresholds was displayed. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 fibroblast growth factor 2 Cavia porcellus 30-34 12566319-5 2003 Using the Dx5 derivative of MES-SA cells in which P-gp is overexpressed, we show that the level of endogenous P-gp decreases with increased expression of exogenous LanCl-2 and that cells with reduced P-gp show increased sensitivity to Adriamycin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 ATP binding cassette subfamily B member 1 Homo sapiens 50-54 12566319-5 2003 Using the Dx5 derivative of MES-SA cells in which P-gp is overexpressed, we show that the level of endogenous P-gp decreases with increased expression of exogenous LanCl-2 and that cells with reduced P-gp show increased sensitivity to Adriamycin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 ATP binding cassette subfamily B member 1 Homo sapiens 110-114 12566319-5 2003 Using the Dx5 derivative of MES-SA cells in which P-gp is overexpressed, we show that the level of endogenous P-gp decreases with increased expression of exogenous LanCl-2 and that cells with reduced P-gp show increased sensitivity to Adriamycin. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 ATP binding cassette subfamily B member 1 Homo sapiens 110-114 12579585-4 2003 MM-GB/SA binding free energy calculations of DES in the ER-alpha and ERR-gamma structures suggest that DES exhibits a greater free energy of binding in the agonist bound conformation of ER-alpha, while the antagonist bound conformation is preferred for ERR-gamma. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 6-8 estrogen receptor 1 Homo sapiens 56-64 12579585-4 2003 MM-GB/SA binding free energy calculations of DES in the ER-alpha and ERR-gamma structures suggest that DES exhibits a greater free energy of binding in the agonist bound conformation of ER-alpha, while the antagonist bound conformation is preferred for ERR-gamma. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 6-8 estrogen related receptor gamma Homo sapiens 69-78 12579585-4 2003 MM-GB/SA binding free energy calculations of DES in the ER-alpha and ERR-gamma structures suggest that DES exhibits a greater free energy of binding in the agonist bound conformation of ER-alpha, while the antagonist bound conformation is preferred for ERR-gamma. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 6-8 estrogen receptor 1 Homo sapiens 186-194 12579585-4 2003 MM-GB/SA binding free energy calculations of DES in the ER-alpha and ERR-gamma structures suggest that DES exhibits a greater free energy of binding in the agonist bound conformation of ER-alpha, while the antagonist bound conformation is preferred for ERR-gamma. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 6-8 estrogen related receptor gamma Homo sapiens 253-262 12100485-2 2002 The induction of PR1 by SA and functional analogues has been found to strictly correlate with the activity of the signalling pathway controlled by both phyA and phyB photoreceptors. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 pathogenesis-related protein 1 Arabidopsis thaliana 17-20 12468816-8 2002 The higher B27 expression in the SA group was not due to higher cell activation as it was not correlated with CD69 and CD25 expression in PBMCs or with the level of IFN-gamma. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 melanocortin 2 receptor accessory protein Homo sapiens 11-14 12484505-3 2002 We investigated the possible associations between SA gene polymorphism and both hypertension and the prognosis of renal function in patients with immunoglobulin A nephropathy (IgAN). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 50-52 IGAN1 Homo sapiens 176-180 12153971-8 2002 However, Sa(O(2)) with ascent was significantly associated with the ACE genotype in the rapid ascent group (p = 0.01) with a relatively sustained Sa(O(2)) in the II subjects. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 9-11 angiotensin I converting enzyme Homo sapiens 68-71 12153971-8 2002 However, Sa(O(2)) with ascent was significantly associated with the ACE genotype in the rapid ascent group (p = 0.01) with a relatively sustained Sa(O(2)) in the II subjects. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 146-148 angiotensin I converting enzyme Homo sapiens 68-71 11488598-3 2001 Caspase-3 was also activated by SA-liposome treatment. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 caspase 3 Mus musculus 0-9 11773387-6 2002 Infection by SA-dependent or SA-independent rotavirus strains was 2- to 10-fold more productive in VLA-2-expressing CHO cells than in parental CHO cells, and the increased susceptibility to infection was blocked with anti-VLA-2 antibody. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 integrin subunit alpha 2 Homo sapiens 99-104 11773387-6 2002 Infection by SA-dependent or SA-independent rotavirus strains was 2- to 10-fold more productive in VLA-2-expressing CHO cells than in parental CHO cells, and the increased susceptibility to infection was blocked with anti-VLA-2 antibody. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 integrin subunit alpha 2 Homo sapiens 222-227 11773387-6 2002 Infection by SA-dependent or SA-independent rotavirus strains was 2- to 10-fold more productive in VLA-2-expressing CHO cells than in parental CHO cells, and the increased susceptibility to infection was blocked with anti-VLA-2 antibody. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 29-31 integrin subunit alpha 2 Homo sapiens 99-104 11773387-6 2002 Infection by SA-dependent or SA-independent rotavirus strains was 2- to 10-fold more productive in VLA-2-expressing CHO cells than in parental CHO cells, and the increased susceptibility to infection was blocked with anti-VLA-2 antibody. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 29-31 integrin subunit alpha 2 Homo sapiens 222-227 12060227-5 2002 Accumulation of alpha-DOX1 transcripts is impaired in SA-compromised plants and induced by SA and by chemicals generating nitric oxide (NO), intracellular superoxide or singlet oxygen, three signals mediating host cell death. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 54-56 Peroxidase superfamily protein Arabidopsis thaliana 22-26 12060227-5 2002 Accumulation of alpha-DOX1 transcripts is impaired in SA-compromised plants and induced by SA and by chemicals generating nitric oxide (NO), intracellular superoxide or singlet oxygen, three signals mediating host cell death. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 91-93 Peroxidase superfamily protein Arabidopsis thaliana 22-26 15080492-11 2002 RESULTS: Plasma levels of MCP-1 were significantly higher (261.5+/-40.7 pg/mL vs 73.3+/-3.05 pg/mL; p<0.0002) and also levels of PAI-1 were higher (79.36+/-5.8 ng/mL vs 35.88+/-1.38 ng/mL; p<0.0001) in patients with SA compared with the healthy control subjects. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 222-224 C-C motif chemokine ligand 2 Homo sapiens 26-31 14647800-9 2002 She was undernourished and the laboratory examinations showed urea (69 mg/dl), creatinine (2.2 mg/dl) and creatinine clearance (12.5 ml/min/1.73 m2 SA). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 148-150 CD59 molecule (CD59 blood group) Homo sapiens 136-141 11488598-4 2001 Pretreatment of cells with N-acetylcysteine, a scavenger of reactive oxygen species (ROS), conferred resistance to the induction of the membrane depolarization, cytochrome c release, and caspase-3 activation by SA-liposomes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 211-213 caspase 3 Mus musculus 187-196 10727524-3 2000 Expression of the mutant P-gp in multidrug-resistant variant cell line MES-SA/DxP (DxP) cells was associated with a 2-fold higher basal ATPase activity relative to multidrug-resistant cell line MES-SA/Dx5 (Dx5) cells with wild-type P-gp. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 ATP binding cassette subfamily B member 1 Homo sapiens 25-29 11353541-5 2001 The preponderance of the conjugate produced is 1:1 and 1:2 Ab:SA conjugate. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 IS1 Homo sapiens 44-56 11255012-11 2001 A maximum likelihood tree based upon the conserved regions showed that all sequences except the one from B. subtilis, belong to two basic groups: one the SA-like group including sequences from Archaeoglobus fulgidus and Streptomyces coelicolor, and second, the ACS group. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 154-156 acyl-CoA synthetase short chain family member 2 Homo sapiens 261-264 11197495-2 2001 Our main hypothesis is that the bioerodible copolymer poly(1,6-bis-p-carboxyphenoxyhexane-co-sebacic anhydride) (CPH : SA) undergoes micro-phase separation at certain copolymer compositions due to differences in relative hydrophobicity of the co-monomers, resulting in thermodynamic partitioning of drugs incorporated into these copolymers. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 119-121 carboxypeptidase E Homo sapiens 113-116 11197495-3 2001 We investigate the thermal properties, degree of crystallinity, and surface microstructure of several compositions of CPH : SA using differential scanning calorimetry (DSC), wide-angle X-ray diffraction (WAXD), and atomic force microscopy (AFM). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 124-126 carboxypeptidase E Homo sapiens 118-121 10849420-7 2000 Pulse-chase, Northern, and primer extension analysis of the rRNA biosynthetic pathway indicates that ebp2-1 mutants are defective in processing the 27 SA precursor into the 27 SB pre-rRNA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 151-153 Ebp2p Saccharomyces cerevisiae S288C 101-105 10848828-10 2000 Our present studies show SA as a characteristic feature of MDS and, importantly, demonstrate its link with an altered expression of E2F1 in some MDS patients. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 25-27 E2F transcription factor 1 Homo sapiens 132-136 10727524-3 2000 Expression of the mutant P-gp in multidrug-resistant variant cell line MES-SA/DxP (DxP) cells was associated with a 2-fold higher basal ATPase activity relative to multidrug-resistant cell line MES-SA/Dx5 (Dx5) cells with wild-type P-gp. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 dynein axonemal heavy chain 8 Homo sapiens 136-142 10727524-3 2000 Expression of the mutant P-gp in multidrug-resistant variant cell line MES-SA/DxP (DxP) cells was associated with a 2-fold higher basal ATPase activity relative to multidrug-resistant cell line MES-SA/Dx5 (Dx5) cells with wild-type P-gp. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 ATP binding cassette subfamily B member 1 Homo sapiens 232-236 10374415-3 1998 Anti-Sa antibody was tested in 40 normal people and 478 connective tissue disease (CTD) patients using Western Blotting (WB). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 5-7 CTD Homo sapiens 83-86 10737789-7 2000 Kinetic analysis of Gal3p+SA reveals that the K(m) for galactose is similar to that of Gal1p, but the K(m) for ATP is increased. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 transcriptional regulator GAL3 Saccharomyces cerevisiae S288C 20-25 10737789-7 2000 Kinetic analysis of Gal3p+SA reveals that the K(m) for galactose is similar to that of Gal1p, but the K(m) for ATP is increased. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 galactokinase Saccharomyces cerevisiae S288C 87-92 11094453-5 2000 Immunologically, Sa is a hapten-carrier antigen in which vimentin is the carrier and citrulline is the hapten. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 vimentin Homo sapiens 57-65 10533199-2 2000 SIPK was activated by SA, a CWD carbohydrate elicitor and two elicitins from Phytophthora spp, bacterial harpin, TMV, and Avr9 from Cladosporium fulvum. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 22-24 mitogen-activated protein kinase homolog NTF4-like Nicotiana tabacum 0-4 11812373-2 1999 METHODS: The p16, p21 and p53 genes mediated by Stearylamine/DOPE (SA liposome) were introduced alone and jointly into the non-small cell lung cancer (NSCLC) cell line A549 and small cell lung cancer (SCLC) SH77. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 67-69 cyclin dependent kinase inhibitor 2A Homo sapiens 13-16 11812373-2 1999 METHODS: The p16, p21 and p53 genes mediated by Stearylamine/DOPE (SA liposome) were introduced alone and jointly into the non-small cell lung cancer (NSCLC) cell line A549 and small cell lung cancer (SCLC) SH77. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 67-69 H3 histone pseudogene 16 Homo sapiens 18-21 11812373-2 1999 METHODS: The p16, p21 and p53 genes mediated by Stearylamine/DOPE (SA liposome) were introduced alone and jointly into the non-small cell lung cancer (NSCLC) cell line A549 and small cell lung cancer (SCLC) SH77. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 67-69 tumor protein p53 Homo sapiens 26-29 11812373-4 1999 RESULTS: The p16, p53 and p21 genes alone mediated by SA liposome can inhibit obviously the growth of NSCLC cell line A549 cells, while the genes were slightly effective on SCLC cell line SH77 cells at day 1, 3, 5 after transfecting the genes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 54-56 cyclin dependent kinase inhibitor 2A Homo sapiens 13-16 11812373-4 1999 RESULTS: The p16, p53 and p21 genes alone mediated by SA liposome can inhibit obviously the growth of NSCLC cell line A549 cells, while the genes were slightly effective on SCLC cell line SH77 cells at day 1, 3, 5 after transfecting the genes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 54-56 tumor protein p53 Homo sapiens 18-21 11812373-4 1999 RESULTS: The p16, p53 and p21 genes alone mediated by SA liposome can inhibit obviously the growth of NSCLC cell line A549 cells, while the genes were slightly effective on SCLC cell line SH77 cells at day 1, 3, 5 after transfecting the genes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 54-56 H3 histone pseudogene 16 Homo sapiens 26-29 9669657-3 1998 In this study, we evaluated a panel of morpholino antisense (M-AS) oligomers for their ability to inhibit tumor necrosis factor-alpha (TNF-alpha) production by primary murine alveolar macrophages (AMs) and compared them with the more commonly used phosphorothioate oligonucleotides (S-AS). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 283-287 tumor necrosis factor Mus musculus 135-144 10225814-12 1999 A significant correlation was demonstrated between IgGs to HSP 90 kDa and two other serological markers for RA, rheumatoid factor, and anti-Sa antibody; there were no correlations with antikeratin antibody, antiperinuclear factor, or anti-RA 33. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 140-142 heat shock protein 90 alpha family class A member 1 Homo sapiens 59-65 10227815-8 1999 Moreover, AUR as well as GST suppressed the expression of CD98 and CD71 on SA-stimulated B cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 solute carrier family 3 member 2 Homo sapiens 58-62 10227815-8 1999 Moreover, AUR as well as GST suppressed the expression of CD98 and CD71 on SA-stimulated B cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 transferrin receptor Homo sapiens 67-71 9918234-9 1999 In patients with long standing RA, statistically significant associations were found between the presence of anti-Sa and the following variables: RF (p<0.0001), AKA (p<0.0001), APF (p<0.00001), and HLA DRB1*04 or 01 (p<0.01). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 114-116 major histocompatibility complex, class II, DR beta 1 Homo sapiens 207-215 9852896-10 1998 Maximal and high-affinity binding sites for IGF-I receptor in the HOCM were greater (P < 0.01 and P < 0.05) than the levels in AS, SA, and TM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 137-139 insulin like growth factor 1 receptor Homo sapiens 44-58 9852896-11 1998 The maximal receptor binding sites for TGF-beta 1 in HOCM were greater (P < 0.05) than those for SA and TM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 100-102 transforming growth factor beta 1 Homo sapiens 39-49 9743600-1 1998 An earlier report indicated that a 26-amino-acid peptide (SA), comprised of the nuclear localization signal (NLS) of fibroblast growth factor-1 (FGF-1) and a membrane-permeable peptide, was able to stimulate DNA synthesis after it was taken up by NIH3T3 fibroblasts. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 58-60 fibroblast growth factor 1 Mus musculus 117-143 9743600-1 1998 An earlier report indicated that a 26-amino-acid peptide (SA), comprised of the nuclear localization signal (NLS) of fibroblast growth factor-1 (FGF-1) and a membrane-permeable peptide, was able to stimulate DNA synthesis after it was taken up by NIH3T3 fibroblasts. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 58-60 fibroblast growth factor 1 Mus musculus 145-150 9743600-2 1998 Here, we report that SA, but not a mutant with the NLS motif destroyed, induced DNA synthesis in BALB/c3T3 murine fibroblasts, human vascular endothelial (HUVE) cells, and primary cultured hepatocytes, although the activity was weaker than that of FGF-1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 21-23 fibroblast growth factor 1 Homo sapiens 248-253 9743600-5 1998 At high cell densities, SA-induced G1 cyclin expression and DNA synthesis were more strongly inhibited than those induced by FGF-1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 fibroblast growth factor 1 Mus musculus 125-130 9664144-6 1998 So and Sa only slightly potentiated the cytotoxic responses to TNF, C6-Cer or melphalan. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 7-9 tumor necrosis factor Homo sapiens 63-66 9659241-7 1998 The frequencies of the most common SA genotype (homozygous for the NAT2*5 allele) were higher in patients than in controls (27% v 15%, respectively). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 35-37 N-acetyltransferase 2 Homo sapiens 67-71 9368557-12 1997 We could demonstrate that the SA-SIP30 was able to distinguish patients with lacunar infarctions from patients with cortical or subcortical lesions. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 ZW10 interacting kinetochore protein Homo sapiens 33-38 9486497-3 1998 We report 14 patients who underwent HLA-identical sibling-matched alloBMT with marrow-enriched for CD34 cells using the Isolex 300 SA device. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 131-133 CD34 molecule Homo sapiens 99-103 9460529-12 1997 The % coefficients of variation (% CVs) of HH15 and LHL15 were improved in the order manual-inter observer (M-inter), manual-intra observer (M-intra) and semi-automated-inter observer (SA-inter); % CVs of HH15 were 2.26% for M-inter, 1.55% for M-intra and 0.07% for SA-inter, and % CVs of LHL15 were 2.29% for M-inter, 0.46% for M-intra and 0.07% for SA-inter. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 185-187 heparan sulfate 6-O-sulfotransferase 1 Homo sapiens 43-47 9460529-12 1997 The % coefficients of variation (% CVs) of HH15 and LHL15 were improved in the order manual-inter observer (M-inter), manual-intra observer (M-intra) and semi-automated-inter observer (SA-inter); % CVs of HH15 were 2.26% for M-inter, 1.55% for M-intra and 0.07% for SA-inter, and % CVs of LHL15 were 2.29% for M-inter, 0.46% for M-intra and 0.07% for SA-inter. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 266-268 heparan sulfate 6-O-sulfotransferase 1 Homo sapiens 43-47 9361093-6 1997 These data demonstrate that infusion of SA results in significant stimulation of PP secretion during high-G infusion, whereas IA has no effect. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 pancreatic polypeptide Rattus norvegicus 81-83 9038218-8 1997 Transfection of the mutant mdr1 gene into drug-sensitive MES-SA sarcoma cells confers resistance to both doxorubicin and PSC 833. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 61-63 ATP binding cassette subfamily B member 1 Homo sapiens 27-31 9199758-9 1997 Bovine serum albumin release from poly(TMA-Tyr:SA:CPP) microspheres is also pH sensitive, being enhanced at high pH and depressed under acidic conditions. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 albumin Homo sapiens 7-20 9034205-8 1997 To determine whether the increase in transcriptional activity of the LDL-R gene was secondary to changes in the cholesterol regulatory pool we performed experiments in which the cell cholesterol content was modified by the addition of either 25-hydroxycholesterol and mevalonate or inhibitors of ACAT activity (SA-58035 and progesterone). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 311-313 low density lipoprotein receptor Homo sapiens 69-74 7932409-7 1994 Antibodies to Sa were essentially found in sera from patients with RA (specificity 98.9%) being found only in 3 patients whose arthritides did not fulfill the ACR criteria. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 acrosin Homo sapiens 159-162 8831372-2 1996 Total root mean square amplitude of the QRS (RMSt) from 70 to 250 Hz was decreased in the 12 SA-ECGs accompanying rejection compared with the 65 SA-ECGs without rejection (26.0 +/- 13.2 mcV vs 37.7 +/- 13.6 mcV, p < 0.01), and the RMSt, terminal 40 msec root mean square voltage (RMS40), and the filtered QRS duration (QRSd) were all decreased for SA-ECGs with rejection compared with those without rejection when evaluated from 125 to 250 Hz (12.3 +/- 7.0 mcV vs 17.5 +/- 6.3 mcV, 10.4 +/- 5.1 mcV vs 14.9 +/- 7.4 mcV, and 78.8 +/- 6.0 msec vs 85.1 +/- 9.5 msec, respectively, p < 0.05 for all comparisons). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 93-95 rhabdomyosarcoma 2 associated transcript Homo sapiens 45-49 9389070-2 1996 The CA125 levels of the 40 canses of ovarian cancer were higher than those of cervical cancer and corpus cancer (P < 0.05); the SS, PLR and AC of CA125 in ovarian cancer were higher than those of LDH, SA and CR (P < 0.05); the SS of CA125 in ovarian cancer was higher than that of LDH isoenzyme (P < 0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 204-206 mucin 16, cell surface associated Homo sapiens 4-9 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 interleukin 10 Homo sapiens 9-14 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 Fc gamma receptor and transporter Homo sapiens 45-56 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 interleukin 2 Homo sapiens 60-64 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 107-109 interleukin 2 receptor subunit alpha Homo sapiens 76-80 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 119-121 interleukin 10 Homo sapiens 9-14 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 119-121 Fc gamma receptor and transporter Homo sapiens 45-56 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 119-121 interleukin 2 Homo sapiens 60-64 8069928-5 1994 In fact, IL-10 upregulated the expression of alpha-chain of IL-2 receptors (CD25) on B cells stimulated by SA alone or SA + IL-2 for 72 hr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 119-121 interleukin 2 receptor subunit alpha Homo sapiens 76-80 8811198-6 1996 These data suggest that SA-1042 exerts its antiviral effects by targeting the V3 loop as well as the CD4 binding site on gp120. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 CD4 molecule Homo sapiens 101-104 8811198-6 1996 These data suggest that SA-1042 exerts its antiviral effects by targeting the V3 loop as well as the CD4 binding site on gp120. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 inter-alpha-trypsin inhibitor heavy chain 4 Homo sapiens 121-126 8928730-0 1996 Doxorubicin selection for MDR1/P-glycoprotein reduces swelling-activated K+ and Cl- currents in MES-SA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 100-102 ATP binding cassette subfamily B member 1 Homo sapiens 26-30 8928730-0 1996 Doxorubicin selection for MDR1/P-glycoprotein reduces swelling-activated K+ and Cl- currents in MES-SA cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 100-102 ATP binding cassette subfamily B member 1 Homo sapiens 31-45 8874965-7 1996 Both of the class IV beta-tubulin isotype transcripts (human 5 beta and beta 2, Class IVa and IVb, respectively) were expressed in dividing K562 and MES-SA cells at twice the levels found in resting cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 153-155 tubulin beta 4B class IVb Homo sapiens 61-78 8589524-4 1995 Two of the other observed differences in the coding region (amino acid residue 12 Leu, Gpi1-sa CTC, Gpi1-sb CTG and amino acid residue 17 Arg, Gpi1-sa CGC, Gpi1-sb CGT) are silent and do not affect the predicted amino acid residues on translation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 92-94 glucose-6-phosphate isomerase 1 Mus musculus 87-91 8391872-10 1993 In addition, the proliferative response and cytotoxicity of the anergic CTL to Sa cells could be restored after the cells had been rested for 7 days to allow reexpression of TCR. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 79-81 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 174-177 1360777-1 1992 The duration of the incubation period for scrapie, a fatal transmissible neurodegenerative disorder of sheep and goats, is mainly determined by the Sip gene, which has 2 alleles (sA--susceptible and pA--resistant). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 179-181 major prion protein Ovis aries 148-151 8460888-11 1993 In the neuronal branch of the SA lineage, how is the acquisition of NGF-responsiveness and NGF-dependence controlled, and what is the relationship of these events to the expression of p140trk and p75? 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 Chromatin assembly factor 1, p105 subunit Drosophila melanogaster 196-199 1360777-9 1992 Results indicated that b+ and b- are markers for the Sip sA and pA alleles, respectively. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 57-59 major prion protein Ovis aries 53-56 1382611-2 1992 AFP or SA immobilized on nitrocellulose membranes (AFP-NC or SA-NC) were used as affinity matrices to purify cell membrane proteins with affinity for AFP (AFP-BP) and for SA (SA-BP) from membrane-enriched extracts of Raji cells (a B-lymphoma cell line), as well as for normal resting and activated peripheral blood lymphocytes (PBMC). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 7-9 alpha fetoprotein Homo sapiens 51-54 1382611-2 1992 AFP or SA immobilized on nitrocellulose membranes (AFP-NC or SA-NC) were used as affinity matrices to purify cell membrane proteins with affinity for AFP (AFP-BP) and for SA (SA-BP) from membrane-enriched extracts of Raji cells (a B-lymphoma cell line), as well as for normal resting and activated peripheral blood lymphocytes (PBMC). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 7-9 alpha fetoprotein Homo sapiens 51-54 1382611-2 1992 AFP or SA immobilized on nitrocellulose membranes (AFP-NC or SA-NC) were used as affinity matrices to purify cell membrane proteins with affinity for AFP (AFP-BP) and for SA (SA-BP) from membrane-enriched extracts of Raji cells (a B-lymphoma cell line), as well as for normal resting and activated peripheral blood lymphocytes (PBMC). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 61-63 alpha fetoprotein Homo sapiens 0-3 1325283-6 1992 The results show that TNF significantly decreases the correlation time, i.e. it increases the fluidity of SA-1 cell membranes. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 106-108 tumor necrosis factor Mus musculus 22-25 1321053-9 1992 Compared to untreated control HL-60 cells, cells exposed to SA for 48 h exhibited comparable to increased immunoreactive MPO in the ER, despite the absence of heme-dependent peroxidase reactivity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 60-62 myeloperoxidase Homo sapiens 121-124 1321053-10 1992 The data indicate that SA inhibits formation of enzymatically active MPO and that in the presence of SA, the ER contains a form(s) of MPO that lacks enzymatic reactivity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 23-25 myeloperoxidase Homo sapiens 69-72 1321053-10 1992 The data indicate that SA inhibits formation of enzymatically active MPO and that in the presence of SA, the ER contains a form(s) of MPO that lacks enzymatic reactivity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 23-25 myeloperoxidase Homo sapiens 134-137 1321053-10 1992 The data indicate that SA inhibits formation of enzymatically active MPO and that in the presence of SA, the ER contains a form(s) of MPO that lacks enzymatic reactivity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 101-103 myeloperoxidase Homo sapiens 134-137 1681027-6 1991 Val 112 appears to be linked to a short incubation period of experimentally induced scrapie in the Cheviot sheep and therefore with the Sip sA allele. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 140-142 major prion protein Ovis aries 136-139 33816432-2 2021 The synthesized SA/p(AAc)/o-MWCNTs HNC was used to remove methylene blue (MB) from aqueous solution. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 16-18 glycine-N-acyltransferase Homo sapiens 21-24 2141251-6 1990 Treatment of the T cell subsets with mitomycin C decreased or abrogated the helper function along with a decrease in IL2 production by the T cell subsets in SA stimulated cultures. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 157-159 interleukin 2 Homo sapiens 117-120 33825400-6 2021 Following TNF-alpha treatment, higher SA beta-Gal activity improved. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 38-40 tumor necrosis factor Homo sapiens 10-19 34861335-7 2022 The farther the horizontal sampling conducted from the Pa and Sa, the greater the structural similarity of the microbial community at the genus level, higher the catalase, acidic protease, and neutral phosphatase activities, and lower the alkaline phosphatase activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 62-64 catalase Homo sapiens 162-187 2009228-3 1991 SHB was highly correlated with SA (r = 0.75; P less than 0.001) but even more highly with SGC (r = 0.89; P greater than 0.001). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 31-33 SH2 domain containing adaptor protein B Homo sapiens 0-3 2009228-8 1991 We suggest that the fluctuations in SHB:SA ratio correspond to the relative rates of secretion of 18OHB and aldosterone and that this ratio is modulated either by ACTH or by cortisol. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 SH2 domain containing adaptor protein B Homo sapiens 36-39 33770168-7 2021 Finally, we show that cas-c1 mutation acts on SA-dependent response to pathogens by mechanisms other than the protein ubiquitination or the increase of monomerization and entry to the nucleus of the central regulator of the SA-mediated response NPR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 regulatory protein (NPR1) Arabidopsis thaliana 245-249 33770168-7 2021 Finally, we show that cas-c1 mutation acts on SA-dependent response to pathogens by mechanisms other than the protein ubiquitination or the increase of monomerization and entry to the nucleus of the central regulator of the SA-mediated response NPR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 224-226 regulatory protein (NPR1) Arabidopsis thaliana 245-249 25040736-4 2014 SIRT1 overexpression reversed the increased PAI-1 expression in senescent human umbilical vein endothelial cells (HUVECs) and aortas of old mice, accompanied by decreased SA-beta-gal activity in vitro and improved endothelial function and reduced arterial stiffness in vivo. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 171-173 sirtuin 1 Homo sapiens 0-5 34973379-3 2022 Melatonin and SA applied jointly or alone enhanced nitrogen metabolism by triggering the activities of glutamate synthase, glutamine synthetase, and nitrite reductases and nitrate. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 glutamate-ammonia ligase Homo sapiens 123-143 33816432-8 2021 The SA/p(AAc)/o-MWCNTs HNC exhibited a maximum adsorption capacity of 1596.0 mg/g at 25 C. This adsorbent showed excellent MB uptake and good regeneration ability. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 glycine-N-acyltransferase Homo sapiens 9-12 34910213-8 2022 Crossing fah1 fah2 loh2 with the SA synthesis mutant sid2-2, and with the SA signaling mutants enhanced disease susceptibility 1-2 (eds1-2) and phytoalexin deficient 4-1 (pad4-1), revealed that lesions are SA- and EDS1-dependent. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 ferulic acid 5-hydroxylase 1 Arabidopsis thaliana 9-13 34910213-8 2022 Crossing fah1 fah2 loh2 with the SA synthesis mutant sid2-2, and with the SA signaling mutants enhanced disease susceptibility 1-2 (eds1-2) and phytoalexin deficient 4-1 (pad4-1), revealed that lesions are SA- and EDS1-dependent. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 33-35 ADC synthase superfamily protein Arabidopsis thaliana 53-57 34596247-2 2021 Recent studies have suggested the role of MYC2 as a negative regulator of SA-mediated defense against bacterial pathogens. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 74-76 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 42-46 34596247-3 2021 By using myc2 mutant and constitutively MYC2-expressing plants, we further show that MYC2 also positively influences SA-mediated defense. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 117-119 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 85-89 34596247-5 2021 MYC2 promotes pathogen-induced callose deposition, SA biosynthesis, expression of PR1 gene, and SA-responsiveness. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 51-53 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 0-4 34596247-10 2021 Hyper-resistance of MYC2 over-expressing plants is largely light-dependent, which is in agreement with the role of MYC2 in SA biosynthesis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 123-125 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 115-119 34596247-11 2021 The results altogether demonstrate that MYC2 possesses dual regulatory roles in SA biosynthesis, SA signaling, PTI, and ETI in Arabidopsis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 80-82 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 40-44 34596247-11 2021 The results altogether demonstrate that MYC2 possesses dual regulatory roles in SA biosynthesis, SA signaling, PTI, and ETI in Arabidopsis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 97-99 Basic helix-loop-helix (bHLH) DNA-binding family protein Arabidopsis thaliana 40-44 34868098-10 2021 Our results proposed a novel mechanism of counter defense signaling pathways used by Agrobacterium, suggesting that VirE3 and JAZ8 may antagonistically modulate the salicylic acid/jasmonic acid (SA/JA)-mediated plant defense signaling response during Agrobacterium infection. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 195-197 hypothetical protein Agrobacterium tumefaciens 116-121 34912223-8 2021 Both glibenclamide and SA extract significantly decreased levels of TLR-4, MYD88, pro-inflammatory cytokines TNF-alpha, and TRAF-6 in pancreatic tissue homogenates, which correlated well with minimal pancreatic inflammatory cell infiltration. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 23-25 toll-like receptor 4 Rattus norvegicus 68-73 34492499-0 2021 LncRNA NONHSAT009968 inhibits the osteogenic differentiation of hBMMSCs in SA-induced inflammation via Wnt3a. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 75-77 Wnt family member 3A Homo sapiens 103-108 34492499-7 2021 In sum, the results suggested that lncNONHSAT009968 inhibited osteogenic differentiation of hBMMSCs in SA-induced inflammation through Wnt3a, which may have affected the occurrence and development of osteomyelitis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 103-105 Wnt family member 3A Homo sapiens 135-140 34639142-6 2021 The results indicate that there are considerable differences in the performance of the docking programs and that DOCK 6 with GB/SA rescoring performs better than the other programs. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 128-130 dedicator of cytokinesis 6 Homo sapiens 113-119 34770742-16 2021 PSMA binding affinities of AAZTA5.SA.KuE and DATA5m.SA.KuE were in the nanomolar range. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 52-54 folate hydrolase 1 Homo sapiens 0-4 34729155-11 2021 Furthermore, the administration of rST6GAL1 resulted in the enrichment of SA-IgG in a concentration-dependent manner. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 74-76 ST6 beta-galactoside alpha-2,6-sialyltransferase 1 Rattus norvegicus 35-43 34729155-12 2021 In addition, as compared to control, purified SA-IgG-treated PBMCs showed a significant decrease in the expression of IL-6 and TNF-alpha. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 interleukin 6 Homo sapiens 118-122 34729155-12 2021 In addition, as compared to control, purified SA-IgG-treated PBMCs showed a significant decrease in the expression of IL-6 and TNF-alpha. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 tumor necrosis factor Homo sapiens 127-136 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 serpin family A member 3 Homo sapiens 74-98 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 apolipoprotein E Homo sapiens 100-161 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 C-C motif chemokine ligand 23 Homo sapiens 163-196 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 interleukin 6 Homo sapiens 198-211 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 sphingomyelin phosphodiesterase 3 Homo sapiens 213-246 34737220-6 2022 Ten proteins were elevated in SA versus MMA in both U-BIOPRED and BIOAIR (alpha-1-antichymotrypsin, apolipoprotein-E, complement component 9, complement factor I, macrophage inflammatory protein-3, interleukin-6, sphingomyelin phosphodiesterase 3, RANK, TGF-beta1, and glutathione S-transferase). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 transforming growth factor beta 1 Homo sapiens 254-263 34620426-5 2021 Enhanced resistance in cipk14 mutants were accompanied by increased accumulation of SA and elevated expression of defense marker genes (PR1, EDS1, EDS5, ICS1). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 84-86 serine/threonine protein kinase 1 Arabidopsis thaliana 23-29 34745087-8 2021 p16 was upregulated in the SA-betagal positive cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 27-29 cyclin dependent kinase inhibitor 2A Homo sapiens 0-3 34696216-8 2021 This paper describes the use of the O3039 vaccine strain as an alternative, either alone or in combination with the O1 Manisa vaccine strain with virulent challenge by a O/ME-SA/Ind-2001d sub-lineage virus from Algeria (O/ALG/3/2014). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 175-177 ALG3 alpha-1,3- mannosyltransferase Bos taurus 222-227 34327762-5 2021 To investigate the roles of this serine residue, we made an antibody specific for S530-phosphorylated human GPNMB and a point mutant in which S530 is replaced by an alanine (A) residue, GPNMB(SA). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 192-194 glycoprotein nmb Homo sapiens 186-191 34327762-6 2021 Established GPNMB(SA) overexpressing cells showed a significant reduction in sphere formation in vitro and tumor growth in vivo, as a result of decreased stemness-related gene expression compared to that in GPNMB(WT) expressing cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 glycoprotein nmb Homo sapiens 12-17 34327762-7 2021 Additionally, GPNMB(SA) impaired GPNMB-mediated cellular migration. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 20-22 glycoprotein nmb Homo sapiens 14-19 34327762-7 2021 Additionally, GPNMB(SA) impaired GPNMB-mediated cellular migration. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 20-22 glycoprotein nmb Homo sapiens 33-38 34495872-9 2021 HSP90 interacts with and regulates SA-beta-Gal protein stabilization in senescent ARPE-19 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 35-37 heat shock protein 90 alpha family class A member 1 Homo sapiens 0-5 34659297-8 2021 Global transcriptome analysis indicates that agrobacteria induce various plant defense pathways, including reactive oxygen species (ROS) production, ethylene (ET), and salicylic acid- (SA-) mediated defense responses, and that MKK4/MKK5 is essential for the induction of these pathways. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 185-187 MAP kinase kinase 5 Arabidopsis thaliana 232-236 34284139-4 2021 IGFBP3 knockdown in MESCs committed to H2O2-induced senescence led to partial abrogation of p21/Rb axis, to elevated ERK phosphorylation and to increase in SA-beta-gal activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 156-158 insulin like growth factor binding protein 3 Homo sapiens 0-6 34130162-5 2021 With an adsorption ability superior to that of plain SA and GO/SA, the optimized GO@PAN-PPy-2(1)/SA exhibited good experimental maximum adsorption capacities for Cr(VI) (~133.7 mg/g) and Cu(II) (~87.2 mg/g) at pH 3.0, which were better than those of many other similar sorbents. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 53-55 pancreatic polypeptide 2, pseudogene Homo sapiens 88-93 34130162-5 2021 With an adsorption ability superior to that of plain SA and GO/SA, the optimized GO@PAN-PPy-2(1)/SA exhibited good experimental maximum adsorption capacities for Cr(VI) (~133.7 mg/g) and Cu(II) (~87.2 mg/g) at pH 3.0, which were better than those of many other similar sorbents. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 63-65 pancreatic polypeptide 2, pseudogene Homo sapiens 88-93 34130162-5 2021 With an adsorption ability superior to that of plain SA and GO/SA, the optimized GO@PAN-PPy-2(1)/SA exhibited good experimental maximum adsorption capacities for Cr(VI) (~133.7 mg/g) and Cu(II) (~87.2 mg/g) at pH 3.0, which were better than those of many other similar sorbents. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 97-99 pancreatic polypeptide 2, pseudogene Homo sapiens 88-93 34927885-6 2021 For OER, (Fe,Co)-SA/CS attained its anodic current density of 10 mA cm-2 at an overpotential of 360 mV. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 17-19 citrate synthase Homo sapiens 20-22 34312404-2 2021 The QDs/SA were first bound to biotinylated NS1 antibody (Ab) and the QDs/SA-Ab conjugates were then used to detect the NS1 antigen (Ag) in the Ag concentration range of 1 pM to 120 nM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 8-10 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 44-47 34312404-2 2021 The QDs/SA were first bound to biotinylated NS1 antibody (Ab) and the QDs/SA-Ab conjugates were then used to detect the NS1 antigen (Ag) in the Ag concentration range of 1 pM to 120 nM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 8-10 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 120-123 34312404-2 2021 The QDs/SA were first bound to biotinylated NS1 antibody (Ab) and the QDs/SA-Ab conjugates were then used to detect the NS1 antigen (Ag) in the Ag concentration range of 1 pM to 120 nM. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 74-76 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 120-123 34312404-4 2021 Fluorescence emission spectra of QDs/SA-Ab-Ag conjugates showed that the magnitude of fluorescence quenching was linearly proportional to the NS1 Ag concentration and it nicely followed the Stern-Volmer (SV) equation in phosphate buffer solution. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 37-39 protein tyrosine phosphatase non-receptor type 11 Homo sapiens 142-145 34257160-6 2021 The inhibition of Akt1 strongly reduced the percentage of SA-beta-Gal-positive cells in the alpha2beta1-depleted cell population, while the inhibition of Akt2 did not have a noticeable effect. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 58-60 AKT serine/threonine kinase 1 Homo sapiens 18-22 34101281-10 2021 Mechanistically, miR-26a, which is enriched in SA-Exo, improved angiogenesis both in SHED and HUVECs via regulating TGF-beta/SMAD2/3 signalling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 microRNA 26a-1 Homo sapiens 17-24 34101281-10 2021 Mechanistically, miR-26a, which is enriched in SA-Exo, improved angiogenesis both in SHED and HUVECs via regulating TGF-beta/SMAD2/3 signalling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 transforming growth factor alpha Homo sapiens 116-124 34101281-10 2021 Mechanistically, miR-26a, which is enriched in SA-Exo, improved angiogenesis both in SHED and HUVECs via regulating TGF-beta/SMAD2/3 signalling. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 SMAD family member 2 Homo sapiens 125-132 34101281-11 2021 CONCLUSIONS: In summary, these data reveal that SA-Exo shuttled miR-26a promotes angiogenesis via TGF-beta/SMAD2/3 signalling contributing to SHED aggregate-based pulp tissue regeneration. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-50 microRNA 26a-1 Homo sapiens 64-71 34063046-5 2021 The promoter of AtWAKL10 contains various defense and hormone responsive elements, and its expression could be significantly induced by exogenous ABA, JA and SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 158-160 WALL ASSOCIATED KINASE (WAK)-LIKE 10 Arabidopsis thaliana 16-24 34063608-10 2021 We further showed alteration in the; (i) tissue luminescence and fluorescence, (ii) mRNA and protein expressions of senescent markers and SASP genes, and (iii) SA-beta-gal activity in CS-exposed young and old p16-3MR mice as compared to their air controls. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 160-162 cyclin dependent kinase inhibitor 2A Mus musculus 209-212 34445714-8 2021 HY2 was then found to specifically mediate 215 differentially regulated proteins (DRPs), which, according to GO enrichment analysis, were mainly involved in ion homeostasis, flavonoid biosynthetic and metabolic pathways, hormone response (SA, JA, ABA, ethylene), the reactive oxygen species (ROS) metabolic pathway, photosynthesis, and detoxification pathways to respond to salt stress. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 239-241 phytochromobilin:ferredoxin oxidoreductase, chloroplast / phytochromobilin synthase (HY2) Arabidopsis thaliana 0-3 34101281-11 2021 CONCLUSIONS: In summary, these data reveal that SA-Exo shuttled miR-26a promotes angiogenesis via TGF-beta/SMAD2/3 signalling contributing to SHED aggregate-based pulp tissue regeneration. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-50 transforming growth factor alpha Homo sapiens 98-106 34101281-11 2021 CONCLUSIONS: In summary, these data reveal that SA-Exo shuttled miR-26a promotes angiogenesis via TGF-beta/SMAD2/3 signalling contributing to SHED aggregate-based pulp tissue regeneration. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 48-50 SMAD family member 2 Homo sapiens 107-114 34110666-10 2021 RESULTS: The depletion of PTN increased the ratio of SA-beta-gal positive cells, upregulated the expression of p16, and downregulated the expression of TERT and p-p38. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 53-55 pleiotrophin Homo sapiens 26-29 34110666-11 2021 Furthermore, 50 pg/ml of PTN recombinant protein rescued these changes the altered ratio of SA-beta-gal positive cells, decreased the expression of p16, enhanced TERT and p-p38 expression, as well as telomere activity, caused by PTN depletion and long-term culture. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 92-94 pleiotrophin Homo sapiens 25-28 34072612-4 2021 Here, we show that both BAG2 and BAG6 are expressed in various tissues and are upregulated by salt, mannitol, and heat treatments and by stress-related hormones including ABA, ethylene, and SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 190-192 BCL-2-associated athanogene 2 Arabidopsis thaliana 24-28 34072612-4 2021 Here, we show that both BAG2 and BAG6 are expressed in various tissues and are upregulated by salt, mannitol, and heat treatments and by stress-related hormones including ABA, ethylene, and SA. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 190-192 BCL-2-associated athanogene 6 Arabidopsis thaliana 33-37 34927885-7 2021 Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 66-68 citrate synthase Homo sapiens 69-71 34927885-7 2021 Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 66-68 citrate synthase Homo sapiens 186-188 34927885-7 2021 Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 183-185 citrate synthase Homo sapiens 69-71 34927885-7 2021 Interestingly, the oxygen electrode activity (DeltaE) for (Fe,Co)-SA/CS and commercial Pt/C-RuO2 is calculated to be 0.73 V, exhibiting the bifunctional catalytic activity of (Fe,Co)-SA/CS. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 183-185 citrate synthase Homo sapiens 186-188 35546754-13 2022 The results suggested that the relieving effect of MSCs against SA-AKI may be partially mediated by the induction of Tregs and inhibition of Th17 cells via the Gal-9/Tim-3 pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 lectin, galactose binding, soluble 9 Mus musculus 160-165 34122058-6 2021 SARS-CoV-2 recognizes O-acetylated neuraminic acids and also several membrane proteins, such as ACE2, as the result of evolutionary switches of O-Ac SA recognition specificities. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 149-151 angiotensin converting enzyme 2 Homo sapiens 96-100 35500311-7 2022 Ultimately, the quenching labels of streptavidin modified Pt nanoparticles functionalized polydopamine composites (SA-Pt@PDA) were introduced via biotin and streptavidin recognition, realizing ECL emission quenching of S2O82-/O2 system for "on-off" detection of BCR-ABL fusion gene. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 115-117 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 262-269 35421617-7 2022 Thus, injectable BG/sodium alginate (BG/SA) hydrogels loaded with MMP9-siNP can significantly accelerate the healing process of full-thickness excision wounds of diabetic rats by decreasing MMP-9 expression, improving collagen synthesis, and enhancing angiogenesis in the wounds, thereby demonstrating their great application potential in treating diabetic chronic wounds. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 matrix metallopeptidase 9 Rattus norvegicus 190-195 35421617-10 2022 In the present work, an injectable bioglass/sodium alginate (BG/SA) hydrogel loaded with MMP9-siNP was developed; this hydrogel significantly accelerated the healing process of full-thickness excision wounds of diabetic rats by decreasing MMP-9 expression, improving collagen accumulation, and enhancing angiogenesis in the wounds. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 matrix metallopeptidase 9 Rattus norvegicus 239-244 35238389-7 2022 We demonstrated that the deregulation in hydrogen peroxide and superoxide homeostasis, but not of singlet oxygen, was partially due to SA accumulation in siz1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 135-137 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 154-158 35119649-11 2022 Live/died staining showed that adult stem cells could stably survive in Gel/SA/CMCS hydrogels for at least 7 days. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 76-78 cerebral malaria susceptibility in CBA/N Mus musculus 79-83 35119649-14 2022 Therefore, Gel/SA/CMCS hydrogel is a strong candidate for biological tissue engineering materials. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 cerebral malaria susceptibility in CBA/N Mus musculus 18-22 35257727-1 2022 Sodium alginate/krill protein/polyacrylamide (SA/AKP/PAM) hydrogel with "covalent bond-ion complex-hydrogen bond" multi-network structure was prepared by covalent cross-linking and complexion ion crosslinking using SA, AKP, and acrylamide (AM) as raw materials. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 peptidylglycine alpha-amidating monooxygenase Homo sapiens 53-56 35257727-1 2022 Sodium alginate/krill protein/polyacrylamide (SA/AKP/PAM) hydrogel with "covalent bond-ion complex-hydrogen bond" multi-network structure was prepared by covalent cross-linking and complexion ion crosslinking using SA, AKP, and acrylamide (AM) as raw materials. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 215-217 peptidylglycine alpha-amidating monooxygenase Homo sapiens 53-56 35257727-9 2022 These excellent properties of ionic cross-linked SA/AKP/PAM hydrogels have broad applications prospects in flexible electronic devices, sensors, soft electronic skins, and tissue engineering. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 49-51 peptidylglycine alpha-amidating monooxygenase Homo sapiens 56-59 35546754-13 2022 The results suggested that the relieving effect of MSCs against SA-AKI may be partially mediated by the induction of Tregs and inhibition of Th17 cells via the Gal-9/Tim-3 pathway. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 hepatitis A virus cellular receptor 2 Mus musculus 166-171 35229599-4 2022 This work develops analytical gradient theory for spin-free SA-DSRG-MRPT2(c) with the density-fitting approximation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 60-62 spindlin 1 Homo sapiens 50-54 35234208-13 2022 CONCLUSIONS: The combination of plasma CCL3+KC can predict SA-AKI development in mice at 24-hours following CLP. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 59-61 chemokine (C-C motif) ligand 3 Mus musculus 39-43 35591203-7 2022 Among the seven participants who completed both blocks of training, the change in the SARA scores and SARAposture&gait sub-scores following training with vibrotactile SA was not significantly different from the change achieved following training without SA (p>0.05). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 167-169 zinc finger FYVE-type containing 9 Homo sapiens 86-90 35451190-9 2022 RESULTS: The number of times pain complaints were made per patient per day (NPPD) on postoperative days (POD) 1 and 2 was significantly lower in the SA group than in the ODA group (POD 1; 1.12 +- 1.21 vs 2.62 +- 1.89, p < 0.01; POD 2; 0.45 +- 0.86 vs. 1.31 +- 1.69, p < 0.01). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 149-151 coronin 7 Homo sapiens 85-117 35108500-10 2022 This effect of SA seems to be related to the higher number of c-Fos/TH+ neurons in the A1 and A2. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 15-17 Fos proto-oncogene, AP-1 transcription factor subunit Rattus norvegicus 62-67 35378512-5 2022 Downregulation of IGFBP5 via siRNA in P2 MEFs increased the number of SA-beta-GAL-positive cells, upregulated p16 and p19, and inhibited cell growth. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 70-72 insulin-like growth factor binding protein 5 Mus musculus 18-24 35390228-2 2022 Therefore, we conducted experiments to investigate whether GATA4 accumulation induces SA-PCH, and whether Bmi-1-RING1B promotes GATA4 ubiquitination and its selective autophagic degradation to prevent SA-PCH. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 201-203 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 106-111 35390228-2 2022 Therefore, we conducted experiments to investigate whether GATA4 accumulation induces SA-PCH, and whether Bmi-1-RING1B promotes GATA4 ubiquitination and its selective autophagic degradation to prevent SA-PCH. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 201-203 ring finger protein 2 Homo sapiens 112-118 35390228-12 2022 Downregulated GATA4 ameliorated SA-PCH and cardiac dysfunction by reducing GATA4-dependent hypertrophy and SASP-related molecules. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 GATA binding protein 4 Homo sapiens 14-19 35390228-12 2022 Downregulated GATA4 ameliorated SA-PCH and cardiac dysfunction by reducing GATA4-dependent hypertrophy and SASP-related molecules. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 GATA binding protein 4 Homo sapiens 75-80 35390228-15 2022 Adeno-associated viral vector serotype 9 (AAV9)-cytomegalovirus (CMV)-Bmi-1-RING1B treatment significantly attenuated GATA4-dependent SA-PCH through promoting GATA4 autophagic degradation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 134-136 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 70-75 35390228-15 2022 Adeno-associated viral vector serotype 9 (AAV9)-cytomegalovirus (CMV)-Bmi-1-RING1B treatment significantly attenuated GATA4-dependent SA-PCH through promoting GATA4 autophagic degradation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 134-136 ring finger protein 2 Homo sapiens 76-82 35390228-15 2022 Adeno-associated viral vector serotype 9 (AAV9)-cytomegalovirus (CMV)-Bmi-1-RING1B treatment significantly attenuated GATA4-dependent SA-PCH through promoting GATA4 autophagic degradation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 134-136 GATA binding protein 4 Homo sapiens 118-123 35390228-15 2022 Adeno-associated viral vector serotype 9 (AAV9)-cytomegalovirus (CMV)-Bmi-1-RING1B treatment significantly attenuated GATA4-dependent SA-PCH through promoting GATA4 autophagic degradation. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 134-136 GATA binding protein 4 Homo sapiens 159-164 35151436-5 2022 SUNA1 expression is highly induced by Pst DC3000 infection, which is impaired in SA biosynthesis-defective mutant sid2 and signaling mutant npr1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 ADC synthase superfamily protein Arabidopsis thaliana 114-118 35270019-8 2022 Induction of SA-beta-gal activity was prevented by the antioxidant N-acetyl cysteine in endothelial cells from DRG2 KO mice. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 13-15 developmentally regulated GTP binding protein 2 Mus musculus 111-115 35251476-7 2022 With knockdown of CBX4, SA-betagal activity and p16 protein expression increased, and EdU decreased. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 chromobox 4 Homo sapiens 18-22 35252714-7 2022 Furthermore, with increasing the LA/SA, the strength of the gas explosion was reduced significantly. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 gastrin Homo sapiens 60-63 35151436-5 2022 SUNA1 expression is highly induced by Pst DC3000 infection, which is impaired in SA biosynthesis-defective mutant sid2 and signaling mutant npr1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 81-83 regulatory protein (NPR1) Arabidopsis thaliana 140-144 35151436-6 2022 Consistently, SA triggers SUNA1 expression dependent on NPR1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 regulatory protein (NPR1) Arabidopsis thaliana 56-60 35160961-6 2022 Like Sa, we found the highest Sdr for implants subjected only to sandblasting. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 5-7 caveolae associated protein 2 Homo sapiens 30-33 35214088-4 2022 Partial least squares regression (PLS-R) was used to assess the influence of (i) drug physicochemical properties and (ii) age-related changes in simulated GI fluids, as well as (iii) their interactions, on the pediatrics-to-adult solubility ratio (Sp/Sa (%)). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 251-253 renin binding protein Homo sapiens 122-125 35016642-8 2022 In vitro, the results showed that the release of IgG-Gd-IgA1-IC was significantly decreased in peripheral blood mononuclear cells (PBMCs) cultured with SA-IgG from both IgAN patients and healthy controls. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 152-154 immunoglobulin heavy constant alpha 1 Homo sapiens 56-60 35016642-9 2022 The proliferation ability and the release of IL-6, TNF-alpha, and TGF-beta in human mesangial cells (HMCs) were measured after stimulating with SA-IgG-IgA1-IC and NSA-IgG-IgA1-IC. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 144-146 interleukin 6 Homo sapiens 45-49 35016642-9 2022 The proliferation ability and the release of IL-6, TNF-alpha, and TGF-beta in human mesangial cells (HMCs) were measured after stimulating with SA-IgG-IgA1-IC and NSA-IgG-IgA1-IC. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 144-146 tumor necrosis factor Homo sapiens 51-60 35016642-9 2022 The proliferation ability and the release of IL-6, TNF-alpha, and TGF-beta in human mesangial cells (HMCs) were measured after stimulating with SA-IgG-IgA1-IC and NSA-IgG-IgA1-IC. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 144-146 transforming growth factor alpha Homo sapiens 66-74 35016642-9 2022 The proliferation ability and the release of IL-6, TNF-alpha, and TGF-beta in human mesangial cells (HMCs) were measured after stimulating with SA-IgG-IgA1-IC and NSA-IgG-IgA1-IC. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 144-146 immunoglobulin heavy constant alpha 1 Homo sapiens 171-175 35012233-2 2022 In this study, we prepared PVA-CS/SA-Ca2+ core-shell hydrogels with bilayer space by cross-linking PVA and CS to form a core structure and chelating SA and Ca2+ to form a shell structure to achieve multiple substance loading and multifunctional expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 34-36 citrate synthase Homo sapiens 107-109 35012233-2 2022 In this study, we prepared PVA-CS/SA-Ca2+ core-shell hydrogels with bilayer space by cross-linking PVA and CS to form a core structure and chelating SA and Ca2+ to form a shell structure to achieve multiple substance loading and multifunctional expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 149-151 citrate synthase Homo sapiens 31-33 35012233-2 2022 In this study, we prepared PVA-CS/SA-Ca2+ core-shell hydrogels with bilayer space by cross-linking PVA and CS to form a core structure and chelating SA and Ca2+ to form a shell structure to achieve multiple substance loading and multifunctional expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 149-151 citrate synthase Homo sapiens 107-109 35012233-6 2022 The SA concentration and SA/Ca2+ cross-linking time show a positive correlation with the thickness of the shell structure; the PVA/CS mass ratio affects the structural characteristics of the core structure; and a higher CS content indicates the more obvious three-dimensional network structure of the hydrogel. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 25-27 citrate synthase Homo sapiens 220-222 35216293-7 2022 The qRT-PCR data revealed that AtSR1 contributed to increased temperatures-mediated susceptible immune response by regulating SA-related genes in atsr1, such as PR1, ICS1, NPR1, as well as EDS1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 126-128 signal responsive 1 Arabidopsis thaliana 31-36 35216293-7 2022 The qRT-PCR data revealed that AtSR1 contributed to increased temperatures-mediated susceptible immune response by regulating SA-related genes in atsr1, such as PR1, ICS1, NPR1, as well as EDS1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 126-128 signal responsive 1 Arabidopsis thaliana 146-151 35216293-7 2022 The qRT-PCR data revealed that AtSR1 contributed to increased temperatures-mediated susceptible immune response by regulating SA-related genes in atsr1, such as PR1, ICS1, NPR1, as well as EDS1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 126-128 transmembrane protein 37 Homo sapiens 161-164 35216293-7 2022 The qRT-PCR data revealed that AtSR1 contributed to increased temperatures-mediated susceptible immune response by regulating SA-related genes in atsr1, such as PR1, ICS1, NPR1, as well as EDS1. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 126-128 natriuretic peptide receptor 1 Homo sapiens 172-176 35087020-8 2022 In addition, the proper tuning of the immune secretory phenotype (IL1betalow, IL6low, IL10high) associated with a significant reduction in SA-beta Gal-positive area of aorta from AAV-LAV treated mice. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 139-141 interleukin 10 Mus musculus 86-90 35382461-4 2022 The galactose groups covered on MFMSN act as sialylation substrates to bind intracellular SAs competitively, which inhibits the SA expression on the tumor cell surface. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 90-93 acyl-CoA synthetase medium-chain family member 3 Mus musculus 128-130 3133373-3 1988 The mechanism(s) of inhibition of ODC induction by 7 retinobenzoic acids, Am 80, Am 81, Am 580, Am 590, Am 68, Sa 80, and Ch 55 was compared with those by all-trans-retinoic acid and the arotinoid compound 19. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 111-113 ornithine decarboxylase 1 Homo sapiens 34-37 2848688-6 1988 hPTHrP-(1-34) gave a dose-response between 0.2 and 5 ng/ml (5 X 10(-11) and 1.2 X 10(-9) M), was about 3 times more potent than Lilly bovine PTH standard (assuming a SA of 3000 U/mg; 100 U/ml), gave the same maximum response as hPTH-(1-34), and was 20-30% as potent as hPTH-(1-34). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 166-168 parathyroid hormone like hormone Homo sapiens 0-6 2848688-6 1988 hPTHrP-(1-34) gave a dose-response between 0.2 and 5 ng/ml (5 X 10(-11) and 1.2 X 10(-9) M), was about 3 times more potent than Lilly bovine PTH standard (assuming a SA of 3000 U/mg; 100 U/ml), gave the same maximum response as hPTH-(1-34), and was 20-30% as potent as hPTH-(1-34). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 166-168 parathyroid hormone Bos taurus 1-4 2848688-6 1988 hPTHrP-(1-34) gave a dose-response between 0.2 and 5 ng/ml (5 X 10(-11) and 1.2 X 10(-9) M), was about 3 times more potent than Lilly bovine PTH standard (assuming a SA of 3000 U/mg; 100 U/ml), gave the same maximum response as hPTH-(1-34), and was 20-30% as potent as hPTH-(1-34). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 166-168 parathyroid hormone Homo sapiens 0-4 2725819-6 1989 Results indicate that normal human CSF does not contain ChAT and all ACh-SA in CSF reflects non-enzymatic imidazole/histidine-like catalyzed synthesis. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 73-75 colony stimulating factor 2 Homo sapiens 79-82 3140468-3 1988 The Sip gene which controls the incubation periods of experimental scrapie in Cheviot sheep has two alleles; sA which shortens and pA which lengthens the incubation periods of most strains of scrapie after the first experimental injection in sheep (the A group of strains). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 109-111 major prion protein Ovis aries 4-7 6298717-2 1983 Alkali and RNase A treatments shortened sa-DNA by 100 nucleotides and we conclude that it contains covalently-linked ribonucleotides. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 40-42 ribonuclease A family member 1, pancreatic Homo sapiens 11-18 3038402-1 1987 Angiotensin converting enzyme inhibition by MK 421, SA 446 or captopril (6 mg/kg/day ip) for up to 6 days induced significant fall in systolic blood pressure and plasma angiotensin II concentration. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 52-54 angiotensinogen Rattus norvegicus 169-183 3027437-12 1986 SA-446 and kallidinogenase significantly inhibited the decrease in plasma renin activity and the increase in urinary aldosterone excretion. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 renin Rattus norvegicus 74-79 2993720-2 1985 Intrarenal infusion of the larger dose of SA-446 (0.1 mg/min) caused an increase in RBF, urine flow and renin release and caused a fall in blood pressure. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 42-44 renin Canis lupus familiaris 104-109 6086184-4 1984 The magnitude of falls in plasma angiotensin II and aldosterone concentration induced by MK 421, SA 446 and captopril was not significantly different between both regular and low sodium diets. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 97-99 angiotensinogen Rattus norvegicus 33-47 6228606-3 1983 Crude lipoteichoic acid extracts of Staphylococcus aureus (SA-LTA) or Bacillus glogigii (Bg-LTA) inhibited cytotoxic reactions when added at day 0 to human or murine mixed lymphocyte reactions (MLR). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 59-61 lymphotoxin alpha Homo sapiens 62-65 6228606-8 1983 The inhibition of human cytotoxic reaction by Sa-LTA derivatized stimulator was not associated with a significant reduction of thymidine incorporation in effector cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 46-48 lymphotoxin alpha Homo sapiens 49-52 3867809-9 1985 Homogeneous 20 alpha-HSD has an SA of 115 mIU/mg, and has been purified 14,000-fold with an overall 68% recovery. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 hydroxysteroid 17-beta dehydrogenase 1 Homo sapiens 12-24 2580127-3 1985 During the infusion of this dose of SA-446, the pressor response to angiotensin I was abolished and the depressor response to bradykinin was markedly potentiated. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 36-38 kininogen 1 Canis lupus familiaris 126-136 899892-2 1977 The use of the sequential gamma camera technique with evaluation of the stored information in the digital analyzing system to investigate CSF dynamics quantitatively has given interesting new information about the circulation in the epicortical SA space. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 245-247 colony stimulating factor 2 Homo sapiens 138-141 6193131-2 1983 SA inhibited heme synthesis in both control and erythropoietin-stimulated cells in a dose-dependent fashion; at 10(-3) M, inhibition was complete, whereas at 10(-7) M, there was no significant effect. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 erythropoietin Rattus norvegicus 48-62 6193131-5 1983 SA caused an almost complete suppression of globin formation in both erythropoietin-stimulated and unstimulated cells as early as five hours after the addition of the inhibitor. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 erythropoietin Rattus norvegicus 69-83 6766756-4 1980 Sa antibody activity was inhibited by sialyllactose NeuAc (alpha 2 leads to 3) (alpha 2 leads to 6) Gal (beta, 1 leads to 4) Glc like anti-Gd but in contrast to anti-Pr. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 galanin and GMAP prepropeptide Homo sapiens 80-141 153907-1 1979 V. The possible localization of Sa and other sulfhydryl groups in myosin rods. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 32-34 myosin heavy chain 14 Homo sapiens 66-72 153908-2 1979 A possible role of Sa in the myosin-actin interaction. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 19-21 myosin heavy chain 14 Homo sapiens 29-35 146708-5 1978 In addition, a space-filling model around Sa was built up by comparing Sa-peptide with the amino acid sequence around Cys 190 of alpha-tropomyosin, and the high reactivity of Sa with N-ethylmaleimide is considered based on this model. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 42-44 tropomyosin 1 Homo sapiens 129-146 146708-5 1978 In addition, a space-filling model around Sa was built up by comparing Sa-peptide with the amino acid sequence around Cys 190 of alpha-tropomyosin, and the high reactivity of Sa with N-ethylmaleimide is considered based on this model. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 71-73 tropomyosin 1 Homo sapiens 129-146 516653-3 1979 The results from those exminations reveal that HLA-B27 antigen investigations could aid making the diagnosis in cases, suspected of SA, together with the other diagnostic methods. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 132-134 major histocompatibility complex, class I, B Homo sapiens 47-54 33989128-6 2021 The level of nitrate reductase (NR) was almost the same in all genotypes (WT, siz1-3, ndr1, npr1, siz1-3 ndr1, and siz1-3 npr1), regardless of the ammonium treatment, suggesting that exogenous ammonium supply to ndr1 siz1-3 and npr1 siz1-3 double mutants does not have any effect on their growth and NR levels, but decreases the SA level. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 329-331 nitrate reductase 1 Arabidopsis thaliana 13-30 195936-3 1977 The effect of Sa modification with NEM, which activates Mg2+-ATPase through an enhancement of the association of actin and myosin, was investigated on the superprecipitation, clearing and Mg2+-ITPase of myosin B with reference to the effect of S1-blocking. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 myosin heavy chain 14 Homo sapiens 123-129 195936-3 1977 The effect of Sa modification with NEM, which activates Mg2+-ATPase through an enhancement of the association of actin and myosin, was investigated on the superprecipitation, clearing and Mg2+-ITPase of myosin B with reference to the effect of S1-blocking. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 14-16 myosin heavy chain 14 Homo sapiens 203-209 195936-5 1977 Superprecipitation induced by ATP was markedly enhanced by Sa-blocking even at high concentrations of Mg2+ and substrate; this may be due to an increase in the affinity of myosin and actin on blocking Sa. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 59-61 myosin heavy chain 14 Homo sapiens 172-178 195936-11 1977 Sa-blocked myosin B showed greater resistance to clearing by ATP, especially in the presence of Ca2+ ions, whereas in the clearing response of actomyosin gel to PPi no difference between Sa-blocked and unmodified myosins B was observed. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 myosin heavy chain 14 Homo sapiens 11-17 195936-13 1977 Based on the above results and preliminary data suggesting that Sa is located in LMM, the interaction of myosin filaments and actin filaments under physiological conditions is discussed. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 64-66 myosin heavy chain 14 Homo sapiens 105-111 125748-6 1975 These all indicate that the blocking by NEM of Sa, the sulfhydryl group related to the activation of Mg2+-ATPase of myosin B, brings about an increase in the association of myosin and actin in the myosin B system, resulting in an activation of Mg2+-ATPase activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 dynein axonemal heavy chain 8 Homo sapiens 106-112 125748-6 1975 These all indicate that the blocking by NEM of Sa, the sulfhydryl group related to the activation of Mg2+-ATPase of myosin B, brings about an increase in the association of myosin and actin in the myosin B system, resulting in an activation of Mg2+-ATPase activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 myosin heavy chain 14 Homo sapiens 116-122 125748-6 1975 These all indicate that the blocking by NEM of Sa, the sulfhydryl group related to the activation of Mg2+-ATPase of myosin B, brings about an increase in the association of myosin and actin in the myosin B system, resulting in an activation of Mg2+-ATPase activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 myosin heavy chain 14 Homo sapiens 173-179 125748-6 1975 These all indicate that the blocking by NEM of Sa, the sulfhydryl group related to the activation of Mg2+-ATPase of myosin B, brings about an increase in the association of myosin and actin in the myosin B system, resulting in an activation of Mg2+-ATPase activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 myosin heavy chain 14 Homo sapiens 173-179 125748-6 1975 These all indicate that the blocking by NEM of Sa, the sulfhydryl group related to the activation of Mg2+-ATPase of myosin B, brings about an increase in the association of myosin and actin in the myosin B system, resulting in an activation of Mg2+-ATPase activity. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 47-49 dynein axonemal heavy chain 8 Homo sapiens 249-255 33412169-5 2021 Biodistribution and cellular uptake study exhibited that PTX/NKSN mainly distributed in tumor site of A549-bearing mice, and coumarin-6(C6) loaded NLS-KALA-SA nanoparticle (C6/NKSN) was predominantly accumulated in the nucleus of A549 cells. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 155-158 complement component 6 Mus musculus 125-138 33786633-9 2021 The percentage of SA-beta-gal-positive cells in senescent PDL25 cells transfected with Lv-miR-216a was decreased 76% by Rb2 treatment compared with the Lv-miR-216a group without Rb2 treatment (P=0.01). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 RB transcriptional corepressor like 2 Homo sapiens 120-123 33989128-1 2021 The siz1 mutants exhibit high SA accumulation and consequently severe dwarfism. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 30-32 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 4-8 33989128-5 2021 The SA level was decreased by exogenous ammonium application in siz1-3 ndr1, siz1-3 npr1, and siz1-3 mutants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 64-70 33989128-5 2021 The SA level was decreased by exogenous ammonium application in siz1-3 ndr1, siz1-3 npr1, and siz1-3 mutants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Arabidopsis thaliana 71-75 33989128-5 2021 The SA level was decreased by exogenous ammonium application in siz1-3 ndr1, siz1-3 npr1, and siz1-3 mutants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 77-83 33989128-5 2021 The SA level was decreased by exogenous ammonium application in siz1-3 ndr1, siz1-3 npr1, and siz1-3 mutants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 regulatory protein (NPR1) Arabidopsis thaliana 84-88 33989128-5 2021 The SA level was decreased by exogenous ammonium application in siz1-3 ndr1, siz1-3 npr1, and siz1-3 mutants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 4-6 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 64-68 33989128-7 2021 Taken together, these results indicate that ammonium acts as a signaling molecule to regulate the SA amount, and NDR1 and NPR1 play a positive role in the ammonium-mediated growth recovery of siz1 mutants. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 98-100 DNA-binding protein with MIZ/SP-RING zinc finger, PHD-finger and SAP domain-containing protein Arabidopsis thaliana 192-196 33994367-9 2021 Down regulation of YAP1 expression reduced the senescence of AECs as determined by ss-galactosidase (SA-beta-gal) staining, which alleviated the clinical symptoms of IPF mice, as determined by body weight and lung index. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 101-103 yes-associated protein 1 Mus musculus 19-23 33939265-4 2021 The greatest age-associated increases were observed in CD8+ T-cell populations, in which the fraction of cells with high SA-betaGal activity reached average levels of 64% in donors in their 60s. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 121-123 CD8a molecule Homo sapiens 55-58 33271248-7 2021 Moreover, SA-FRE increased the phosphorylation of PKC and further stimulated the GLUT4 expression in WAT and skeletal muscle, thus increasing the glucose utilization in vivo. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 10-12 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 81-86 33585848-9 2021 CD28 SA treatment significantly downregulated the expression of MMP-9 on day 7 post stroke. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 5-7 CD28 antigen Mus musculus 0-4 33585848-9 2021 CD28 SA treatment significantly downregulated the expression of MMP-9 on day 7 post stroke. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 5-7 matrix metallopeptidase 9 Mus musculus 64-69 32898442-5 2021 When inhibiting the expression of SIRT1 by EX527, our results showed that TSG reversed the effect of EX527, by promoting the expression level of SIRT1, reducing the expression of SA-beta-gal positive cell and the expression level of p53 and PAI-1 proteins. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 179-181 sirtuin 1 Homo sapiens 34-39 33392891-8 2021 Overexpression of miR-217 promoted the increase of SA-beta-gal positive cells, and inhibited proliferation, migration and angiogenesis during endothelial cell growth. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 51-53 microRNA 217 Homo sapiens 18-25 33314719-15 2021 The expression of P21 and P53 significantly decreased in SNPC-exo-treated NPC after siRNA transfection (P < 0.05), followed by a higher growth rate (2 times higher on the 5th day and 1.5 times higher on the 7th day) and lower percentage of SA-beta-gal-positive NPC (22.5%). 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 240-242 H3 histone pseudogene 16 Homo sapiens 18-21 33585848-12 2021 CD28 SA treatment decreased the expression of MMP-9 and could be a promising therapeutic strategy for the treatment of diabetic stroke. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 5-7 CD28 antigen Mus musculus 0-4 33585848-12 2021 CD28 SA treatment decreased the expression of MMP-9 and could be a promising therapeutic strategy for the treatment of diabetic stroke. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 5-7 matrix metallopeptidase 9 Mus musculus 46-51 33099738-6 2021 According to the results, SA increased malondialdehyde (MDA) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels and decreased glutathione (reduced, GSH) level and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in both tissues. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 catalase Rattus norvegicus 188-196 33099738-6 2021 According to the results, SA increased malondialdehyde (MDA) and 8-hydroxy-2"-deoxyguanosine (8-OHdG) levels and decreased glutathione (reduced, GSH) level and superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities in both tissues. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 26-28 catalase Rattus norvegicus 198-201 33099738-8 2021 In addition, as a result of histopathological examination, it was determined that SA damaged tissue architecture, and as a result of immunohistochemical examination, it increased cardiac Bcl-2-associated X protein (Bax) and cerebral glial fibrillary acidic protein (GFAP) expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 82-84 BCL2 associated X, apoptosis regulator Rattus norvegicus 187-213 33099738-8 2021 In addition, as a result of histopathological examination, it was determined that SA damaged tissue architecture, and as a result of immunohistochemical examination, it increased cardiac Bcl-2-associated X protein (Bax) and cerebral glial fibrillary acidic protein (GFAP) expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 82-84 BCL2 associated X, apoptosis regulator Rattus norvegicus 215-218 33099738-8 2021 In addition, as a result of histopathological examination, it was determined that SA damaged tissue architecture, and as a result of immunohistochemical examination, it increased cardiac Bcl-2-associated X protein (Bax) and cerebral glial fibrillary acidic protein (GFAP) expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 82-84 glial fibrillary acidic protein Rattus norvegicus 233-264 33099738-8 2021 In addition, as a result of histopathological examination, it was determined that SA damaged tissue architecture, and as a result of immunohistochemical examination, it increased cardiac Bcl-2-associated X protein (Bax) and cerebral glial fibrillary acidic protein (GFAP) expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 82-84 glial fibrillary acidic protein Rattus norvegicus 266-270 33612663-10 2021 However, DPSCs on SA-treated c.p.Ti showed the greatest mRNA levels of osteopontin, osteocalcin, and bone sialoprotein, as well as increased Alizarin Red S staining. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 secreted phosphoprotein 1 Rattus norvegicus 71-82 33612663-10 2021 However, DPSCs on SA-treated c.p.Ti showed the greatest mRNA levels of osteopontin, osteocalcin, and bone sialoprotein, as well as increased Alizarin Red S staining. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 18-20 bone gamma-carboxyglutamate protein Rattus norvegicus 84-95 33461716-6 2021 When in the presence of the target visfatin, aptamer specifically combines with the visfatin, which induces the release of Mag-SA/S2 from the Mag-SA/S2/aptamer complex. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 127-129 nicotinamide phosphoribosyltransferase Homo sapiens 35-43 33461716-6 2021 When in the presence of the target visfatin, aptamer specifically combines with the visfatin, which induces the release of Mag-SA/S2 from the Mag-SA/S2/aptamer complex. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 127-129 nicotinamide phosphoribosyltransferase Homo sapiens 84-92 33530947-10 2021 Physiological analyses showed that the superoxide dismutase, peroxidase and catalase activities were lower in ERF2-silenced plants than in control plants, and the SA and JA contents were lower in ERF2-silenced plants than in control plants after inoculation with S. lycopersici. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 163-165 ethylene response factor 2 Solanum lycopersicum 196-200 33530947-15 2021 Interestingly, ERF2 played a key role in multiple SA, JA and ROS signaling pathways to confer resistance to invasion by S. lycopersici. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 50-52 ethylene response factor 2 Solanum lycopersicum 15-19 33271248-9 2021 SA-FRE treatment increased the GLUT4 expression at both gene and protein levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 0-2 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 31-36 33271248-10 2021 Furthermore, only Go6983, a PKC inhibitor, reversed the SA-FRE-induced GLUT4 translocation and expression at the gene and protein levels. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 56-58 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 71-76 33271248-11 2021 CONCLUSIONS: Generally, SA-FRE ameliorated hyperglycemia, dyslipidemia, and insulin resistance partly through activating PKC/GLUT4 pathway and regulating PPARalpha and PPARgamma expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 125-130 33271248-11 2021 CONCLUSIONS: Generally, SA-FRE ameliorated hyperglycemia, dyslipidemia, and insulin resistance partly through activating PKC/GLUT4 pathway and regulating PPARalpha and PPARgamma expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 peroxisome proliferator activated receptor alpha Mus musculus 154-163 33271248-11 2021 CONCLUSIONS: Generally, SA-FRE ameliorated hyperglycemia, dyslipidemia, and insulin resistance partly through activating PKC/GLUT4 pathway and regulating PPARalpha and PPARgamma expression. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 24-26 peroxisome proliferator activated receptor gamma Mus musculus 168-177 33302170-10 2021 15 wt % PLA was selected as the control group and among all concentrations of CS and SA, groups containing 3 wt% CS and 3 wt% SA showed significantly superior and favorable features in printing quality. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 85-87 citrate synthase Homo sapiens 113-115 33128213-5 2021 We observed increased percentage of cells with increased SA-beta-galactosidase activity, decreased cell viability/proliferation and increased level of p21 in both models. 2-chloro-10-(4'(N-beta-hydroxyethyl)piperazinyl-1')acetylphenothiazine 57-59 galactosidase beta 1 Homo sapiens 60-78