PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 31989790-6 2020 To illustrate on-demand Bio-MOD production feasibility, histidine tagged G-CSF was manufactured daily under good manufacturing practice (GMP)-like conditions prior to administration over a 16-day period. Histidine 56-65 colony stimulating factor 3 (granulocyte) Mus musculus 73-78 31990367-0 2020 Histidine triad nucleotide-binding proteins HINT1 and HINT2 Share Similar Substrate Specificities and Little Affinity for the Signaling Dinucleotide Ap4A. Histidine 0-9 histidine triad nucleotide binding protein 1 Homo sapiens 44-49 31990367-0 2020 Histidine triad nucleotide-binding proteins HINT1 and HINT2 Share Similar Substrate Specificities and Little Affinity for the Signaling Dinucleotide Ap4A. Histidine 0-9 histidine triad nucleotide binding protein 2 Homo sapiens 54-59 31816046-0 2020 Histidine 131 in presenilin 1 is the pH-sensitive residue that causes the increase in Abeta42 level in acidic pH. Histidine 0-9 presenilin 1 Homo sapiens 17-29 31816046-8 2020 Among the histidines facing the luminal side of presenilin (PS) 1, which is the catalytic subunit of gamma-secretase, point mutations at H131 had no effect on the Abeta42 production ratio in an acidic environment. Histidine 10-20 presenilin 1 Homo sapiens 48-65 31816046-9 2020 We also observed an increase in Abeta42 ratio when histidine was introduced into N137 of PS2, which is the corresponding residue of H131 in PS1. Histidine 51-60 taste 2 receptor member 64 pseudogene Homo sapiens 89-92 31816046-9 2020 We also observed an increase in Abeta42 ratio when histidine was introduced into N137 of PS2, which is the corresponding residue of H131 in PS1. Histidine 51-60 presenilin 1 Homo sapiens 140-143 31583975-7 2020 Then, both histidine-tagged proteins p53 and ERK1 were immobilized by the Ni-Co layer in a microarray format for subsequent immunoassay and fluorescence detection. Histidine 11-20 tumor protein p53 Homo sapiens 37-40 31988244-4 2020 Here, using expression of two plant AMTs (AtAMT1;2 and AMT2) in budding yeast, we found that systematic replacements in the conserved twin-histidine motif, a hallmark of most AMTs/Meps/Rhs, alter substrate recognition, transport capacities, the nitrogen (N)-isotope selection and selectivity against K+ AMT-specific differences were found for histidine variants. Histidine 140-149 ammonium transporter 1;2 Arabidopsis thaliana 43-51 31988244-4 2020 Here, using expression of two plant AMTs (AtAMT1;2 and AMT2) in budding yeast, we found that systematic replacements in the conserved twin-histidine motif, a hallmark of most AMTs/Meps/Rhs, alter substrate recognition, transport capacities, the nitrogen (N)-isotope selection and selectivity against K+ AMT-specific differences were found for histidine variants. Histidine 344-353 ammonium transporter 1;2 Arabidopsis thaliana 43-51 31718975-7 2020 Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM. Histidine 73-82 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 17-20 31718975-7 2020 Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM. Histidine 73-82 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 167-170 31718975-7 2020 Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM. Histidine 84-87 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 17-20 31718975-7 2020 Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM. Histidine 84-87 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 167-170 31718975-7 2020 Furthermore, the PIM-Fe3+ ensemble can serve as a fluorescent sensor for histidine (His) detection via the removal of Fe3+ from the ensemble by His and the release of PIM. Histidine 144-147 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 17-20 31718975-8 2020 The sequential detection of Fe3+ and His exhibited on-off-on phenomenon, and the Fe3+ and His detection limits were 0.11 and 3.06 muM, respectively. Histidine 90-93 latexin Homo sapiens 130-133 32020293-7 2020 Cyt reduction was accompanied with rupture of ferro-Met 80 and occupation of this hem coordination site by a histidine His-33/26. Histidine 109-118 cytochrome c, somatic Homo sapiens 0-3 32031206-6 2020 The Eaf3 CD structure revealed an unexpected histidine residue in the aromatic cage essential for binding H3K4me and H3K36me. Histidine 45-54 Eaf3p Saccharomyces cerevisiae S288C 4-8 31752058-0 2020 Roles of Protein Histidine Phosphatase 1 (PHPT1) in Brown Adipocyte Differentiation. Histidine 17-26 phosphohistidine phosphatase 1 Homo sapiens 42-47 31752058-5 2020 In addition, the expression level of protein histidine phosphatase 1 (PHPT1), a major mammalian phosphohistidine phosphatase, is reduced rapidly at the early phase of differentiation and recovers at the later phase. Histidine 45-54 phosphohistidine phosphatase 1 Homo sapiens 55-68 31752058-5 2020 In addition, the expression level of protein histidine phosphatase 1 (PHPT1), a major mammalian phosphohistidine phosphatase, is reduced rapidly at the early phase of differentiation and recovers at the later phase. Histidine 45-54 phosphohistidine phosphatase 1 Homo sapiens 70-75 32068980-11 2020 Surprisingly, Zn2+ plus histidine resembles the kainate only control with more seizure severity in Cav2.3-competent than in deficient mice. Histidine 24-33 calcium channel, voltage-dependent, R type, alpha 1E subunit Mus musculus 99-105 31907281-7 2020 We found that five histidine residues in helices 5-8 of apoA-I are preferably cross-linked by oxPLs, forming stable pyrrole adducts with lysine residues in the helices 3-4 of another apoA-I or in the central domain of apoA-II. Histidine 19-28 apolipoprotein A1 Homo sapiens 56-62 31907281-7 2020 We found that five histidine residues in helices 5-8 of apoA-I are preferably cross-linked by oxPLs, forming stable pyrrole adducts with lysine residues in the helices 3-4 of another apoA-I or in the central domain of apoA-II. Histidine 19-28 apolipoprotein A1 Homo sapiens 183-189 31907281-7 2020 We found that five histidine residues in helices 5-8 of apoA-I are preferably cross-linked by oxPLs, forming stable pyrrole adducts with lysine residues in the helices 3-4 of another apoA-I or in the central domain of apoA-II. Histidine 19-28 apolipoprotein A2 Homo sapiens 218-225 32042016-1 2020 In several carcinomas, the SET Domain Containing 3, Actin Histidine Methyltransferase (SETD3) is associated with oncogenesis. Histidine 58-67 SET domain containing 3, actin histidine methyltransferase Homo sapiens 87-92 31593685-6 2020 Since DEPC, PGO, and DIDS are membrane impermeable reagents, we mutated to other residues individual histidine, arginine, and lysine residues located within the extracellular regions of hMCT1. Histidine 101-110 solute carrier family 16 member 1 Homo sapiens 186-191 31767724-2 2020 Our previous work reported a pneumococcal-specific chimeric lysin, ClyJ, which combines the CHAP (cysteine, histidine-dependent amidohydrolase/peptidase) enzymatically active domain (EAD) from the PlyC lysin and the cell-wall binding domain (CBD) from the phage SPSL1 lysin, which imparts choline binding specificity. Histidine 108-117 synaptopodin 2-like Mus musculus 92-96 31907206-1 2020 Morgana/CHORDC1/CHP1 is a highly conserved CHORD (Cysteine and Histidine Rich Domain) containing protein that has been proposed to function as an Hsp90 co-chaperone. Histidine 63-72 CHORD Drosophila melanogaster 0-7 31993215-0 2020 Molecular basis for histidine N3-specific methylation of actin H73 by SETD3. Histidine 20-29 SET domain containing 3, actin histidine methyltransferase Homo sapiens 70-75 31694953-14 2020 Different from the canonical NLS in other herpes viral homologs, BFLF2 contains a novel importin-dependent nuclear localization signal, including R47, K50, R52 and several neighboring discontinuous arginine and histidine residues. Histidine 211-220 nuclear egress lamina protein Human gammaherpesvirus 4 65-70 31851326-6 2020 The interaction between PQLC2 and the C9orf72 complex is negatively regulated by arginine, lysine, and histidine, the amino acids that PQLC2 transports across the membrane of lysosomes. Histidine 103-112 solute carrier family 66 member 1 Homo sapiens 24-29 31851326-6 2020 The interaction between PQLC2 and the C9orf72 complex is negatively regulated by arginine, lysine, and histidine, the amino acids that PQLC2 transports across the membrane of lysosomes. Histidine 103-112 C9orf72-SMCR8 complex subunit Homo sapiens 38-45 31851326-6 2020 The interaction between PQLC2 and the C9orf72 complex is negatively regulated by arginine, lysine, and histidine, the amino acids that PQLC2 transports across the membrane of lysosomes. Histidine 103-112 solute carrier family 66 member 1 Homo sapiens 135-140 32042934-5 2020 Mutational analysis of H123 position indicates that the missense mutation at first position of the codon CAC by G or T, result in aspartic acid or tyrosine instead of histidine and can have negative effect on the function of PTEN. Histidine 167-176 phosphatase and tensin homolog Homo sapiens 225-229 31918397-9 2020 It was shown that compounds 18-20 uniquely show interactions with histidine residues in the catalytic site of DNase I and 5-LO enzyme. Histidine 66-75 deoxyribonuclease 1 Bos taurus 110-123 31622711-1 2020 Here, we present a specific biosensor based on the detection of glycated hemoglobin (HbA1c) proteolytic digestion product, fructosyl valyl histidine (Fru-ValHis). Histidine 123-148 zinc finger and BTB domain containing 22 Homo sapiens 150-153 31739063-5 2020 Furthermore, biological pathways analysis demonstrated that histidine metabolism, nitrogen metabolism, tryptophan and part glycerophospholipids metabolism were notably modified by PSG treatment in ALI rats. Histidine 60-69 pregnancy-specific beta 1-glycoprotein Rattus norvegicus 180-183 31707649-3 2020 Here we describe a protocol for quick protein production and solubility screen using TissueLyser II system from Qiagen enabling simultaneous processing of 96 protein samples, with application to recombinant proteins encompassing two intracellular domains of ethylene-recognizing sensor histidine kinase ETHYLENE RESPONSE1 (ETR1) from Arabidopsis thaliana. Histidine 286-295 Signal transduction histidine kinase, hybrid-type, ethylene sensor Arabidopsis thaliana 323-327 31707652-2 2020 Here, we describe reliable procedures for affinity purification, cofactor-binding analysis and antibody-based detection of phosphohistidine (pHis), on the putative human His kinases NME1 (NDPK-A) and NME2 (NDPK-B) and the glycolytic phosphoglycerate mutase PGAM1. Histidine 170-173 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 182-186 31707652-2 2020 Here, we describe reliable procedures for affinity purification, cofactor-binding analysis and antibody-based detection of phosphohistidine (pHis), on the putative human His kinases NME1 (NDPK-A) and NME2 (NDPK-B) and the glycolytic phosphoglycerate mutase PGAM1. Histidine 170-173 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 188-194 31707653-2 2020 We describe a procedure for determining the stoichiometry of histidine phosphorylation on the human histidine kinases NME1 and NME2 by intact mass spectrometry under conditions that retain this acid-labile protein modification. Histidine 61-70 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 118-122 31707653-2 2020 We describe a procedure for determining the stoichiometry of histidine phosphorylation on the human histidine kinases NME1 and NME2 by intact mass spectrometry under conditions that retain this acid-labile protein modification. Histidine 61-70 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 127-131 31707653-2 2020 We describe a procedure for determining the stoichiometry of histidine phosphorylation on the human histidine kinases NME1 and NME2 by intact mass spectrometry under conditions that retain this acid-labile protein modification. Histidine 100-109 NME/NM23 nucleoside diphosphate kinase 1 Homo sapiens 118-122 31707653-2 2020 We describe a procedure for determining the stoichiometry of histidine phosphorylation on the human histidine kinases NME1 and NME2 by intact mass spectrometry under conditions that retain this acid-labile protein modification. Histidine 100-109 NME/NM23 nucleoside diphosphate kinase 2 Homo sapiens 127-131 32072885-4 2020 In addition, the coding sequence of TC-1+6 histidine (rTC-1) was inserted into the pET22b(+) vector and cloned and expressed by E.coli BL21 and finally purified through nickel affinity column. Histidine 43-52 Serum cholesterol level QTL 22 Rattus norvegicus 54-59 31983877-5 2019 The transgenic plants that overexpressed SYNC1 gene had increased asparagine and lysine contents in matured seeds, and increased aspartate, lysine, alanine and histidine contents in germinated seeds. Histidine 160-169 Class II aminoacyl-tRNA and biotin synthetases superfamily protein Arabidopsis thaliana 41-46 31860659-9 2019 The results indicated that the activity of IGPD and its histidine content decreased significantly under 1/2 MIC (40 mug/mL) ISL, and the expression of IGPD gene (hisB) and IGPD protein was significantly down-regulated. Histidine 56-65 imidazoleglycerol-phosphate dehydratase HisB Staphylococcus xylosus 43-47 31600036-1 2019 Histidine decarboxylase (HDC) catalyses the formation of histamine from L-histidine. Histidine 72-83 histidine decarboxylase Homo sapiens 0-23 31600036-1 2019 Histidine decarboxylase (HDC) catalyses the formation of histamine from L-histidine. Histidine 72-83 histidine decarboxylase Homo sapiens 25-28 31561000-6 2019 We show that the production of neurokinin B amyloid is dependent on the phosphate concentration, the pH and the presence of a histidine at position 3 in the primary sequence. Histidine 126-135 tachykinin precursor 3 Homo sapiens 31-43 31984197-4 2019 According to various nuclear magnetic resonance experiments for mutants of C113 and molecular dynamics (MD) simulation of wild-type Pin1, the protonation sate of Sgamma of C113 regulates the hydrogen-bonding network of the dual-histidine motif (H59, H157) whose dynamics may affect substrate binding ability. Histidine 228-237 peptidylprolyl cis/trans isomerase, NIMA-interacting 1 Homo sapiens 132-136 31685617-3 2019 Our data identified environmental changes surrounding residue histidine 266 of POT1 that were dependent on telomere ssDNA substrate length. Histidine 62-71 protection of telomeres 1 Homo sapiens 79-83 31697492-4 2019 Here we compare visible circular dichroism (CD) spectra of Cu2+ loaded on to full-length alphaSyn together with four peptides that model aspects of Cu2+ binding to the N-terminus and histidine50 of alphaSyn. Histidine 183-192 synuclein alpha Homo sapiens 198-206 31697492-6 2019 A similar affinity of 0.3 nM is determined for the tripeptide Met-Asp-Val(MDV) that mimics the N-terminus of alphaSyn, while the incorporation of a putative histidine side chain in the N-terminal complex facilitates the formation of a macrochelate with the histidine, which results in an increase in the affinity for Cu2+ to 0.03 nM at pH 7.4. Histidine 157-166 synuclein alpha Homo sapiens 109-117 31697492-6 2019 A similar affinity of 0.3 nM is determined for the tripeptide Met-Asp-Val(MDV) that mimics the N-terminus of alphaSyn, while the incorporation of a putative histidine side chain in the N-terminal complex facilitates the formation of a macrochelate with the histidine, which results in an increase in the affinity for Cu2+ to 0.03 nM at pH 7.4. Histidine 257-266 synuclein alpha Homo sapiens 109-117 31684160-10 2019 The muscle RING-finger protein-1 expression was decreased in tibialis and urinary 3-methyl-histidine to creatinine ratio slightly lower with the supply of NCP. Histidine 82-100 tripartite motif containing 63 Rattus norvegicus 4-32 31573804-1 2019 Coordination complexes have emerged as prominent modulators of amyloid aggregation via their interaction with the N-terminal histidine residues of amyloid-beta (Abeta). Histidine 125-134 amyloid beta precursor protein Homo sapiens 161-166 31636363-0 2019 A PQ-loop protein Ypq2 is involved in the exchange of arginine and histidine across the vacuolar membrane of Saccharomyces cerevisiae. Histidine 67-76 Ypq2p Saccharomyces cerevisiae S288C 18-22 31636363-3 2019 Here, we show that the uptake activity of arginine driven by an artificially imposed histidine gradient decreased significantly by the disruption of the gene encoding vacuolar PQ-loop protein Ypq2, but not by those of Ypq1 and Ypq3. Histidine 85-94 Ypq2p Saccharomyces cerevisiae S288C 192-196 31636363-6 2019 These results suggest that Ypq2 is responsible for the exchange activity of arginine and histidine across the vacuolar membrane, and the conserved proline residue in the PQ-loop motif is required for the activity. Histidine 89-98 Ypq2p Saccharomyces cerevisiae S288C 27-31 31624291-5 2019 Specifically, the intermediate of the histidine degradation pathway and a marker of folate deficiency, formiminoglutamate, was increased more than 15-fold in livers of Aldh1l1-/- mice. Histidine 38-47 aldehyde dehydrogenase 1 family, member L1 Mus musculus 168-175 31632029-12 2019 Real-time PCR confirmed this result, and showed gene expression increased significantly (OPN 1.84-fold, OCN 1.69-fold) when stem cells were cultured with His-betaCD-PH. Histidine 154-157 oligophrenin 1 Homo sapiens 89-94 31632029-12 2019 Real-time PCR confirmed this result, and showed gene expression increased significantly (OPN 1.84-fold, OCN 1.69-fold) when stem cells were cultured with His-betaCD-PH. Histidine 154-157 bone gamma-carboxyglutamate protein Homo sapiens 104-107 31632029-13 2019 Conclusion: The overall results indicated that His-betaCD-PH is a promising carrier for osteoinductive PH with possible penetration ability and sustained release that reduces BMP2 consumption for differentiation of mesenchymal stem cells to bone tissue. Histidine 47-50 bone morphogenetic protein 2 Homo sapiens 175-179 31656932-2 2019 In the 3" 5" decay pathway, mRNA is degraded by the exosome complex and the resulting cap dinucleotide or short-capped oligonucleotide is hydrolyzed mainly by a decapping scavenger enzyme (DcpS)-a member of the histidine triad family. Histidine 213-222 decapping enzyme, scavenger Homo sapiens 163-189 31656932-2 2019 In the 3" 5" decay pathway, mRNA is degraded by the exosome complex and the resulting cap dinucleotide or short-capped oligonucleotide is hydrolyzed mainly by a decapping scavenger enzyme (DcpS)-a member of the histidine triad family. Histidine 213-222 decapping enzyme, scavenger Homo sapiens 191-195 31645726-5 2019 Multiple histidine residues along the rim of the VISTA extracellular domain mediate binding to the adhesion and co-inhibitory receptor P-selectin glycoprotein ligand-1 (PSGL-1). Histidine 9-18 V-set immunoregulatory receptor Homo sapiens 49-54 31645726-5 2019 Multiple histidine residues along the rim of the VISTA extracellular domain mediate binding to the adhesion and co-inhibitory receptor P-selectin glycoprotein ligand-1 (PSGL-1). Histidine 9-18 selectin P ligand Homo sapiens 135-167 31645726-5 2019 Multiple histidine residues along the rim of the VISTA extracellular domain mediate binding to the adhesion and co-inhibitory receptor P-selectin glycoprotein ligand-1 (PSGL-1). Histidine 9-18 selectin P ligand Homo sapiens 169-175 31551334-4 2019 Php1 tyrosine phosphatase activity was attenuated by mutation of conserved histidine residues that are important for the coordination of metal ions and by mutation of a conserved arginine residue, a key residue for catalysis in other bacterial PHPs. Histidine 75-84 phospholipid phosphatase related 4 Homo sapiens 0-4 31592171-2 2019 Oncogenic mutation in the catalytic subunit p110alpha of PI3Kalpha at the 1047 position in the kinase domain substitutes the histidine with arginine. Histidine 125-134 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 44-53 31592171-2 2019 Oncogenic mutation in the catalytic subunit p110alpha of PI3Kalpha at the 1047 position in the kinase domain substitutes the histidine with arginine. Histidine 125-134 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 57-66