PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
15451553-3	2004	Sub-chronic treatment of animals starting from the lowest dose of glyphosate induced the leakage of hepatic intracellular enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting irreversible damage in hepatocytes.	glyphosate	66-76	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	166-192
15519368-1	2004	Glyphosate [N-(phosphonomethyl)glycine] (GPS; H3G) is a widely used pesticide throughout the world.	glyphosate	0-10	H3.4 histone	Homo sapiens	46-49
15519368-1	2004	Glyphosate [N-(phosphonomethyl)glycine] (GPS; H3G) is a widely used pesticide throughout the world.	glyphosate	12-39	H3.4 histone	Homo sapiens	46-49
15451553-3	2004	Sub-chronic treatment of animals starting from the lowest dose of glyphosate induced the leakage of hepatic intracellular enzymes, alanine aminotransferase (ALT) and aspartate aminotransferase (AST), suggesting irreversible damage in hepatocytes.	glyphosate	66-76	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	194-197
12955571-1	2003	Glyphosate is a non-selective broad-spectrum herbicide that inhibits 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), a key enzyme in the aromatic amino acid biosynthetic pathway in microorganisms and plants.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	69-112
15106882-5	2004	In contrast, many other structurally related compounds (i.e., phosphonoacetic acid, 2-carboxyethyl phosphonic acid, N-phosphonomethyl glycine, N-phosphonomethyl iminodiacetic acid) inhibited AK activity.	glyphosate	116-141	adenosine kinase	Homo sapiens	191-193
12955571-0	2003	Expression of a bacterial aroA mutant, aroA-M1, encoding 5-enolpyruvylshikimate-3-phosphate synthase for the production of glyphosate-resistant tobacco plants.	glyphosate	123-133	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	57-100
12537443-1	2003	A competitive direct enzyme-linked immunosorbent assay (ELISA) and high-pressure liquid chromatographic (HPLC) methods were compared in terms of accuracy and precision for the detection and quantification of glyphosate-spiked Nanopure, tap, and river waters.	glyphosate	208-218	nuclear RNA export factor 1	Homo sapiens	236-239
11208018-0	2001	Plastid-expressed 5-enolpyruvylshikimate-3-phosphate synthase genes provide high level glyphosate tolerance in tobacco.	glyphosate	87-97	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	18-61
11896679-10	2002	In summary, Roundup affects cell cycle regulation by delaying activation of the CDK1/cyclin B complex, by synergic effect of glyphosate and formulation products.	glyphosate	125-135	cyclin dependent kinase 1	Homo sapiens	80-84
11896679-11	2002	Considering the universality among species of the CDK1/cyclin B regulator, our results question the safety of glyphosate and Roundup on human health.	glyphosate	110-120	cyclin dependent kinase 1	Homo sapiens	50-54
11208018-4	2001	We chose to test glyphosate resistance via over-expression in plastids of tolerant forms of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).	glyphosate	17-27	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	92-135
11208018-4	2001	We chose to test glyphosate resistance via over-expression in plastids of tolerant forms of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).	glyphosate	17-27	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	137-142
11208018-7	2001	Plastid-expressed EPSPS could provide very high levels of glyphosate resistance, although levels of resistance in vegetative and reproductive tissues differed depending on EPSPS accumulation levels, and correlated to the plastid abundance in these tissues.	glyphosate	58-68	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	18-23
1369090-6	1992	The glucose-6-phosphate dehydrogenase activity increased with all three treatments, but it decreased after glyphosate treatment, which does not stimulate the formation of peroxides.	glyphosate	107-117	glucose-6-phosphate 1-dehydrogenase, cytoplasmic isoform	Triticum aestivum	4-37
12425094-0	2001	Adjuvant influence on glyphosate efficacy in the presence of CA2+.	glyphosate	22-32	CA2	Hordeum vulgare	61-64
10903418-15	2000	In addition, GPF is a competitive inhibitor of ODC activity in vitro.	glyphosate	13-16	ornithine decarboxylase, structural 1	Mus musculus	47-50
24178424-0	1996	Stability and expression of amplified EPSPS genes in glyphosate resistant tobacco cells and plantlets.	glyphosate	53-63	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	38-43
24178424-1	1996	The stability and expression of amplified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) genes was examined in glyphosate resistant tobacco cells grown in glyphosate-free medium, and in plantlets regenerated from resistant cells.	glyphosate	116-126	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	42-85
24178424-1	1996	The stability and expression of amplified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) genes was examined in glyphosate resistant tobacco cells grown in glyphosate-free medium, and in plantlets regenerated from resistant cells.	glyphosate	116-126	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	87-92
24178424-1	1996	The stability and expression of amplified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) genes was examined in glyphosate resistant tobacco cells grown in glyphosate-free medium, and in plantlets regenerated from resistant cells.	glyphosate	160-170	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	42-85
24178424-1	1996	The stability and expression of amplified 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) genes was examined in glyphosate resistant tobacco cells grown in glyphosate-free medium, and in plantlets regenerated from resistant cells.	glyphosate	160-170	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	87-92
8611529-2	1996	The reaction is inhibited by N-(phosphonomethyl)glycine (Glp), which, in the presence of S3P, binds to EPSP synthase to form a stable ternary complex.	glyphosate	29-55	euchromatic histone lysine methyltransferase 1	Homo sapiens	57-60
2005670-1	1991	Between January, 1986 and September, 1988, the Taiwan National Poison Center recorded 97 telephone consultations (49 male, 48 female) on cases of ingestion of glyphosate-surfactant herbicide concentrate containing the isopropylamine salt of glyphosate (N-phosphonomethyl glycine, CAS 1071-83-6) and a non-ionic tallow amine surfactant.	glyphosate	159-169	BCAR1 scaffold protein, Cas family member	Homo sapiens	280-283
1932690-0	1991	Expression and stability of amplified genes encoding 5-enolpyruvylshikimate-3-phosphate synthase in glyphosate-tolerant tobacco cells.	glyphosate	100-110	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	53-96
1932690-1	1991	Two distinct cDNAs for 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) were obtained from a glyphosate-tolerant tobacco cell line.	glyphosate	96-106	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	23-66
1932690-1	1991	Two distinct cDNAs for 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) were obtained from a glyphosate-tolerant tobacco cell line.	glyphosate	96-106	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	68-73
1932690-4	1991	One cDNA clone, EPSPS-1, represented a gene that was amplified in glyphosate-tolerant cells, while the gene for EPSPS-2 was unaltered in these cells.	glyphosate	66-76	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	16-23
1932690-6	1991	Exposure of unselected cells and tobacco leaves to glyphosate produced a transient increase in EPSPS mRNA.	glyphosate	51-61	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	95-100
1932690-7	1991	However, glyphosate-tolerant cells containing amplified copies of EPSPS genes did not show a similar response following exposure to glyphosate.	glyphosate	9-19	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	66-71
1932690-8	1991	A significant proportion of the EPSPS gene amplification was maintained when tolerant cells were grown in the absence of glyphosate for eight months.	glyphosate	121-131	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	32-37
33825789-7	2021	Resistance monitoring based on plant responses to the application of discriminatory doses of glyphosate (960 g ha-1) or chlorimuron-ethyl (20 g ha-1).	glyphosate	93-103	Rho GTPase activating protein 45	Homo sapiens	111-115
33803994-4	2021	Gene profiling showed that glyphosate changed the expression of DNMT1, DMNT3A, and HDAC3, while AMPA changed the expression of DNMT1 and HDAC3.	glyphosate	27-37	DNA methyltransferase 1	Homo sapiens	64-69
33803994-4	2021	Gene profiling showed that glyphosate changed the expression of DNMT1, DMNT3A, and HDAC3, while AMPA changed the expression of DNMT1 and HDAC3.	glyphosate	27-37	histone deacetylase 3	Homo sapiens	83-88
34864054-6	2022	The decrease of Clusterin mRNAs suggested that glyphosate would target the integrity of Sertoli cells.	glyphosate	47-57	clusterin	Rattus norvegicus	16-25
33812014-7	2021	RESULTS: Five days of repeated exposure to the comintation of LPS and glyphosate resulted in higher neutrophil counts, myloperoxidase, TNF-alpha, IL-6, KC levels, and ICAM-1 and TLR-2 expression compared to the same length of treatment to LPS or glyphosate alone.	glyphosate	70-80	tumor necrosis factor	Mus musculus	135-144
33812014-7	2021	RESULTS: Five days of repeated exposure to the comintation of LPS and glyphosate resulted in higher neutrophil counts, myloperoxidase, TNF-alpha, IL-6, KC levels, and ICAM-1 and TLR-2 expression compared to the same length of treatment to LPS or glyphosate alone.	glyphosate	70-80	interleukin 6	Mus musculus	146-150
33812014-7	2021	RESULTS: Five days of repeated exposure to the comintation of LPS and glyphosate resulted in higher neutrophil counts, myloperoxidase, TNF-alpha, IL-6, KC levels, and ICAM-1 and TLR-2 expression compared to the same length of treatment to LPS or glyphosate alone.	glyphosate	70-80	intercellular adhesion molecule 1	Mus musculus	167-173
33812014-7	2021	RESULTS: Five days of repeated exposure to the comintation of LPS and glyphosate resulted in higher neutrophil counts, myloperoxidase, TNF-alpha, IL-6, KC levels, and ICAM-1 and TLR-2 expression compared to the same length of treatment to LPS or glyphosate alone.	glyphosate	70-80	toll-like receptor 2	Mus musculus	178-183
34543792-7	2022	Mechanistically, the pathological changes in GLY-exposed testis were accompanied by the increased interleukin (IL)-17A production, probably due to gut microbes-derived Th17 cell migration.	glyphosate	45-48	interleukin 17A	Rattus norvegicus	98-118
34543792-9	2022	Taken together, these findings uncover an underlying mechanistic scenario that gut microbiota dysbiosis-driven local IL-17A production is one reason responsible for male reproductive toxicity induced by GLY, which provides new insights into the male reproductive toxicity of GLY in mammals.	glyphosate	203-206	interleukin 17A	Rattus norvegicus	117-123
34543792-9	2022	Taken together, these findings uncover an underlying mechanistic scenario that gut microbiota dysbiosis-driven local IL-17A production is one reason responsible for male reproductive toxicity induced by GLY, which provides new insights into the male reproductive toxicity of GLY in mammals.	glyphosate	275-278	interleukin 17A	Rattus norvegicus	117-123
34906888-0	2022	Glyphosate damages blood-testis barrier via NOX1-triggered oxidative stress in rats: Long-term exposure as a potential risk for male reproductive health.	glyphosate	0-10	NADPH oxidase 1	Rattus norvegicus	44-48
34906888-7	2022	Intriguingly, we identified a marked upregulation of oxidative stress-related gene NOX1 in GLY-exposed testis based on transcriptome analysis.	glyphosate	91-94	NADPH oxidase 1	Rattus norvegicus	83-87
34906888-8	2022	NOX1 knockdown blocked the GLY-induced oxidative stress, as well as prevented BTB-related protein decrease in SCs.	glyphosate	27-30	NADPH oxidase 1	Rattus norvegicus	0-4
34906888-11	2022	Mechanistically, GLY directly interacted with ER-alpha at the site of Pro39 and Lys401 to promote ER-alpha activation, which boosted NOX1 expression to trigger ROS accumulation.	glyphosate	17-20	estrogen receptor 1	Rattus norvegicus	46-54
34906888-11	2022	Mechanistically, GLY directly interacted with ER-alpha at the site of Pro39 and Lys401 to promote ER-alpha activation, which boosted NOX1 expression to trigger ROS accumulation.	glyphosate	17-20	estrogen receptor 1	Rattus norvegicus	98-106
34906888-11	2022	Mechanistically, GLY directly interacted with ER-alpha at the site of Pro39 and Lys401 to promote ER-alpha activation, which boosted NOX1 expression to trigger ROS accumulation.	glyphosate	17-20	NADPH oxidase 1	Rattus norvegicus	133-137
34906888-12	2022	Collectively, these results demonstrate that long-term GLY exposure adversely affects BTB integrity, which disrupts spermatogenesis via activation of ER-alpha/NOX1 axis.	glyphosate	55-58	estrogen receptor 1	Rattus norvegicus	150-158
34906888-12	2022	Collectively, these results demonstrate that long-term GLY exposure adversely affects BTB integrity, which disrupts spermatogenesis via activation of ER-alpha/NOX1 axis.	glyphosate	55-58	NADPH oxidase 1	Rattus norvegicus	159-163
33345705-3	2021	However, the effects of glyphosate on horizontal transfer of conjugative plasmid carrying antibiotic resistance gene (ARG) are largely unknown.	glyphosate	24-34	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	118-121
33345705-4	2021	Here, we explored the ability and potential mechanism of glyphosate for accelerating horizontal transfer of conjugative plasmid-mediated ARG.	glyphosate	57-67	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	137-140
33345705-5	2021	The results showed that glyphosate can effectively boost horizontal transfer rate of conjugative plasmid carrying ARG.	glyphosate	24-34	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	114-117
33345705-7	2021	In conclusion, this study casts new understanding into the biological effects of glyphosate on ARG.	glyphosate	81-91	ABL proto-oncogene 2, non-receptor tyrosine kinase	Homo sapiens	95-98
34626244-6	2021	Repeated exposures to the combination of LPS and glyphosate resulted in robust infiltration of inflammatory cells in the perivascular, peribronchiolar, and alveolar regions, and increases of alveolar septal thicknesses and perivascular spaces in the lungs with intense intercellular adhesion molecule (ICAM) - 1 staining in the perivascular region, but minimal staining in the pulmonary artery endothelium.	glyphosate	49-59	intercellular adhesion molecule 1	Mus musculus	269-311
34151066-0	2021	Glyphosate Interaction with eEF1alpha1 Indicates Altered Protein Synthesis: Evidence for Reduced Spermatogenesis and Cytostatic Effect.	glyphosate	0-10	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	28-38
34833688-7	2021	Experimentally, the proposed phase-sensitive SPR sensor was successfully applied for the detection of small molecules of glyphosate, which is the most frequently used herbicide worldwide.	glyphosate	121-131	sepiapterin reductase	Homo sapiens	45-48
34718976-9	2022	Conversely, a statistically significant decrease was observed in the liver and gill MDA levels and AChE activity of the groups treated with propolis and propolis nanoparticles compared to the groups exposed to glyphosate and fed the basal diet.	glyphosate	210-220	acetylcholinesterase	Oreochromis niloticus	99-103
34438504-3	2021	In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish.	glyphosate	94-97	claudin 5a	Danio rerio	267-276
34438504-3	2021	In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish.	glyphosate	94-97	occludin a	Danio rerio	278-286
34438504-3	2021	In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish.	glyphosate	94-97	amine oxidase copper containing 1	Danio rerio	338-353
34438504-3	2021	In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish.	glyphosate	204-207	claudin 5a	Danio rerio	267-276
34438504-3	2021	In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish.	glyphosate	204-207	occludin a	Danio rerio	278-286
34438504-3	2021	In the current study, a subacute toxicity test of zebrafish exposed to MC-LR (35 mug L-1) and GLY (3.5 mg L-1), either alone or in combination was performed for 21 d. The results showed that MC-LR or/and GLY treatment reduced the mRNA levels of tight junction genes (claudin-5, occludin, and zonula occludens-1) and altered the levels of diamine oxidase and D-lactic, indicating increased intestinal permeability in zebrafish.	glyphosate	204-207	amine oxidase copper containing 1	Danio rerio	338-353
34438504-4	2021	Furthermore, MC-LR and/or GLY treatment remarkably increased the levels of intestinal IL-1beta and IL-8 but decreased the levels of IL-10 and TGF-beta, indicating that MC-LR and/or GLY exposure induced an inflammatory response in the fish gut.	glyphosate	26-29	chemokine (C-X-C motif) ligand 8a	Danio rerio	99-103
34438504-4	2021	Furthermore, MC-LR and/or GLY treatment remarkably increased the levels of intestinal IL-1beta and IL-8 but decreased the levels of IL-10 and TGF-beta, indicating that MC-LR and/or GLY exposure induced an inflammatory response in the fish gut.	glyphosate	26-29	interleukin 10	Danio rerio	132-137
34438504-4	2021	Furthermore, MC-LR and/or GLY treatment remarkably increased the levels of intestinal IL-1beta and IL-8 but decreased the levels of IL-10 and TGF-beta, indicating that MC-LR and/or GLY exposure induced an inflammatory response in the fish gut.	glyphosate	26-29	transforming growth factor, alpha	Danio rerio	142-150
34438504-4	2021	Furthermore, MC-LR and/or GLY treatment remarkably increased the levels of intestinal IL-1beta and IL-8 but decreased the levels of IL-10 and TGF-beta, indicating that MC-LR and/or GLY exposure induced an inflammatory response in the fish gut.	glyphosate	181-184	chemokine (C-X-C motif) ligand 8a	Danio rerio	99-103
34438504-4	2021	Furthermore, MC-LR and/or GLY treatment remarkably increased the levels of intestinal IL-1beta and IL-8 but decreased the levels of IL-10 and TGF-beta, indicating that MC-LR and/or GLY exposure induced an inflammatory response in the fish gut.	glyphosate	181-184	interleukin 10	Danio rerio	132-137
34438504-4	2021	Furthermore, MC-LR and/or GLY treatment remarkably increased the levels of intestinal IL-1beta and IL-8 but decreased the levels of IL-10 and TGF-beta, indicating that MC-LR and/or GLY exposure induced an inflammatory response in the fish gut.	glyphosate	181-184	transforming growth factor, alpha	Danio rerio	142-150
34438504-5	2021	MC-LR and/or GLY exposure also activated superoxide dismutase and catalase, generally upregulated the levels of p53, bax, bcl-2, caspase-3, and caspase-9, downregulated the levels of caspase-8 and caused notable histological injury in the fish gut.	glyphosate	13-16	catalase	Danio rerio	66-74
34438504-5	2021	MC-LR and/or GLY exposure also activated superoxide dismutase and catalase, generally upregulated the levels of p53, bax, bcl-2, caspase-3, and caspase-9, downregulated the levels of caspase-8 and caused notable histological injury in the fish gut.	glyphosate	13-16	tumor protein p53	Danio rerio	112-115
34438504-5	2021	MC-LR and/or GLY exposure also activated superoxide dismutase and catalase, generally upregulated the levels of p53, bax, bcl-2, caspase-3, and caspase-9, downregulated the levels of caspase-8 and caused notable histological injury in the fish gut.	glyphosate	13-16	BCL2 associated X, apoptosis regulator a	Danio rerio	117-120
34438504-5	2021	MC-LR and/or GLY exposure also activated superoxide dismutase and catalase, generally upregulated the levels of p53, bax, bcl-2, caspase-3, and caspase-9, downregulated the levels of caspase-8 and caused notable histological injury in the fish gut.	glyphosate	13-16	BCL2 apoptosis regulator a	Danio rerio	122-127
34438504-5	2021	MC-LR and/or GLY exposure also activated superoxide dismutase and catalase, generally upregulated the levels of p53, bax, bcl-2, caspase-3, and caspase-9, downregulated the levels of caspase-8 and caused notable histological injury in the fish gut.	glyphosate	13-16	caspase 3, apoptosis-related cysteine peptidase a	Danio rerio	129-138
34438504-5	2021	MC-LR and/or GLY exposure also activated superoxide dismutase and catalase, generally upregulated the levels of p53, bax, bcl-2, caspase-3, and caspase-9, downregulated the levels of caspase-8 and caused notable histological injury in the fish gut.	glyphosate	13-16	caspase 9, apoptosis-related cysteine peptidase	Danio rerio	144-153
34438504-5	2021	MC-LR and/or GLY exposure also activated superoxide dismutase and catalase, generally upregulated the levels of p53, bax, bcl-2, caspase-3, and caspase-9, downregulated the levels of caspase-8 and caused notable histological injury in the fish gut.	glyphosate	13-16	caspase 8, apoptosis-related cysteine peptidase	Danio rerio	183-192
34438504-6	2021	Moreover, MC-LR and/or GLY exposure also significantly altered the microbial community in the zebrafish gut and the expression of miRNAs (miR-146a, miR-155, miR-16, miR-21, and miR-223).	glyphosate	23-26	microRNA 146a	Danio rerio	138-146
34438504-6	2021	Moreover, MC-LR and/or GLY exposure also significantly altered the microbial community in the zebrafish gut and the expression of miRNAs (miR-146a, miR-155, miR-16, miR-21, and miR-223).	glyphosate	23-26	microRNA 155	Danio rerio	148-155
34438504-6	2021	Moreover, MC-LR and/or GLY exposure also significantly altered the microbial community in the zebrafish gut and the expression of miRNAs (miR-146a, miR-155, miR-16, miR-21, and miR-223).	glyphosate	23-26	microRNA 16b	Danio rerio	157-163
34438504-6	2021	Moreover, MC-LR and/or GLY exposure also significantly altered the microbial community in the zebrafish gut and the expression of miRNAs (miR-146a, miR-155, miR-16, miR-21, and miR-223).	glyphosate	23-26	microRNA 223	Danio rerio	177-184
34559349-2	2022	Glyphosate is a broad-spectrum herbicide that inactivates the 5-enolpyruvylshikimate 3-phosphate synthase (EPSPS) enzyme and causes plant death.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic	Brassica napus	62-105
34369487-4	2021	This methodology was applied to quantify glyphosate and its metabolite, aminomethylphosphonic acid, in surface water at 12.2 mug mL-1 limit of detection (LOD) via standard addition calibration.	glyphosate	41-51	L1 cell adhesion molecule	Mus musculus	129-133
34131613-7	2021	In the postnatal period, a two-fold increase in glyphosate applications was associated with more youth-reported depression (beta = 1.2, 95% credible intervals (CrI) = 0.2, 2.2), maternal-reported internalizing behaviors (beta = 1.23, 95% CrI = 0.2, 2.3), and anxiety (beta = 1.2, 95% CrI = 0.2, 2.3).	glyphosate	48-58	immunoglobulin kappa variable 2D-19 (pseudogene)	Homo sapiens	124-134
34131613-7	2021	In the postnatal period, a two-fold increase in glyphosate applications was associated with more youth-reported depression (beta = 1.2, 95% credible intervals (CrI) = 0.2, 2.2), maternal-reported internalizing behaviors (beta = 1.23, 95% CrI = 0.2, 2.3), and anxiety (beta = 1.2, 95% CrI = 0.2, 2.3).	glyphosate	48-58	immunoglobulin kappa variable 2D-19 (pseudogene)	Homo sapiens	268-278
35429611-8	2022	Glyphosate suppressed the expression of estrogen receptor 1 (Esr1) and vitellogenin (Vtg) and altered histidine metabolism in exposed hepatocytes.	glyphosate	0-10	estrogen receptor	Salmo salar	40-59
35429611-8	2022	Glyphosate suppressed the expression of estrogen receptor 1 (Esr1) and vitellogenin (Vtg) and altered histidine metabolism in exposed hepatocytes.	glyphosate	0-10	estrogen receptor	Salmo salar	61-65
35429611-8	2022	Glyphosate suppressed the expression of estrogen receptor 1 (Esr1) and vitellogenin (Vtg) and altered histidine metabolism in exposed hepatocytes.	glyphosate	0-10	vitellogenin	Salmo salar	71-83
35429611-8	2022	Glyphosate suppressed the expression of estrogen receptor 1 (Esr1) and vitellogenin (Vtg) and altered histidine metabolism in exposed hepatocytes.	glyphosate	0-10	vitellogenin	Salmo salar	85-88
35429611-9	2022	Increased levels of cholesterol and downregulation of clusterin (Clu) suggest that glyphosate treatment affected membrane stability in Atlantic salmon kidney cells.	glyphosate	83-93	clusterin	Salmo salar	54-63
35429611-9	2022	Increased levels of cholesterol and downregulation of clusterin (Clu) suggest that glyphosate treatment affected membrane stability in Atlantic salmon kidney cells.	glyphosate	83-93	clusterin	Salmo salar	65-68
34850229-8	2022	MON 52276 and glyphosate altered the expression of genes in liver reflecting TP53 activation by DNA damage and circadian rhythm regulation.	glyphosate	14-24	tumor protein p53	Homo sapiens	77-81
34160494-0	2021	A photoelectrochemical sensor based on an acetylcholinesterase-CdS/ZnO-modified extended-gate field-effect transistor for glyphosate detection.	glyphosate	122-132	CDP-diacylglycerol synthase 1	Homo sapiens	63-66
34160494-1	2021	A new photoelectrochemical enzyme biosensor based on an extended-gate field-effect transistor (EGFET) was constructed for the highly sensitive detection of glyphosate based on the inhibition of acetylcholinesterase (AChE) activity by glyphosate.	glyphosate	156-166	acetylcholinesterase (Cartwright blood group)	Homo sapiens	216-220
34160494-1	2021	A new photoelectrochemical enzyme biosensor based on an extended-gate field-effect transistor (EGFET) was constructed for the highly sensitive detection of glyphosate based on the inhibition of acetylcholinesterase (AChE) activity by glyphosate.	glyphosate	234-244	acetylcholinesterase (Cartwright blood group)	Homo sapiens	216-220
35227749-0	2022	Photocatalytic oxidation of glyphosate and reduction of Cr(VI) in water over ACF-supported CoNiWO4-gCN composite under batch and flow conditions.	glyphosate	28-38	ACF	Homo sapiens	77-80
35227749-3	2022	Here, we report an efficient removal of glyphosate (GLP) and Cr(VI) from water under batch as well as continuous flow conditions using the activated carbon fiber (ACF)-supported nanocomposite of CoNiWO4 (CNW) and g-C3N4 (gCN), as a photocatalyst.	glyphosate	40-50	ACF	Homo sapiens	163-166
34151066-5	2021	Cytostatic and antiproliferative effects of glyphosate in GC-1 and SUP-B15 cells were indicated.	glyphosate	44-54	olfactomedin 4	Homo sapiens	58-62
34151066-8	2021	Together, these findings indicate that glyphosate delays protein synthesis through an interaction with eEF1alpha1, thereby suppressing spermatogenesis and cell growth.	glyphosate	39-49	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	103-113
35239060-1	2022	An ultra-sensitive glyphosate nanosensor, based on carbon dots (CDs), was successfully developed with excellent long-wavelength emission (530 nm), a high quantum yield (41.3%), and an impressive detection limit (0.8 ng mL-1).	glyphosate	19-29	L1 cell adhesion molecule	Mus musculus	219-223
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	catalase	Danio rerio	56-59
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	eukaryotic translation initiation factor 2-alpha kinase 3	Danio rerio	218-222
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	eukaryotic translation initiation factor 2A	Danio rerio	224-233
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	activating transcription factor 4a	Danio rerio	243-247
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	X-box binding protein 1	Danio rerio	260-264
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	activating transcription factor 6	Danio rerio	266-270
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	heat shock protein 5	Danio rerio	272-277
35398647-4	2022	In addition, GLY exposure altered the levels of SOD and CAT, increased ROS, promoted malondialdehyde (MDA) content, and significantly altered the levels of endoplasmic reticulum (ER) stress signalling pathway factors (perk, eif2alpha, gadd34, atf4, ire1alpha, xbp1, atf6, hspa5, and chop), suggesting that GLY treatment induced oxidative injury and ER stress in the larvae.	glyphosate	13-16	DNA-damage-inducible transcript 3	Danio rerio	283-287
35398647-5	2022	Further research showed that treatment with a higher concentration of GLY upregulated the levels of iNOS, IL-1beta, and TNF-alpha while inhibiting the expression of IL-10 and TGF-beta, suggesting that GLY causes an inflammatory reaction in the larvae.	glyphosate	70-73	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	120-129
35398647-5	2022	Further research showed that treatment with a higher concentration of GLY upregulated the levels of iNOS, IL-1beta, and TNF-alpha while inhibiting the expression of IL-10 and TGF-beta, suggesting that GLY causes an inflammatory reaction in the larvae.	glyphosate	70-73	interleukin 10	Danio rerio	165-170
35398647-5	2022	Further research showed that treatment with a higher concentration of GLY upregulated the levels of iNOS, IL-1beta, and TNF-alpha while inhibiting the expression of IL-10 and TGF-beta, suggesting that GLY causes an inflammatory reaction in the larvae.	glyphosate	70-73	transforming growth factor, alpha	Danio rerio	175-183
35398647-5	2022	Further research showed that treatment with a higher concentration of GLY upregulated the levels of iNOS, IL-1beta, and TNF-alpha while inhibiting the expression of IL-10 and TGF-beta, suggesting that GLY causes an inflammatory reaction in the larvae.	glyphosate	201-204	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	120-129
35398647-5	2022	Further research showed that treatment with a higher concentration of GLY upregulated the levels of iNOS, IL-1beta, and TNF-alpha while inhibiting the expression of IL-10 and TGF-beta, suggesting that GLY causes an inflammatory reaction in the larvae.	glyphosate	201-204	interleukin 10	Danio rerio	165-170
35398647-5	2022	Further research showed that treatment with a higher concentration of GLY upregulated the levels of iNOS, IL-1beta, and TNF-alpha while inhibiting the expression of IL-10 and TGF-beta, suggesting that GLY causes an inflammatory reaction in the larvae.	glyphosate	201-204	transforming growth factor, alpha	Danio rerio	175-183
35398647-7	2022	Taken together, our results demonstrate that GLY exposure altered the T3/T4 ratio, disturbed the expression patterns of HPT and GH/IGF axis-related genes, and induced oxidative and ER stress, inflammatory reactions, and apoptosis in the zebrafish larvae.	glyphosate	45-48	growth hormone 1	Danio rerio	128-130
35193057-6	2022	Moreover, Atr decreased the mRNA expression and protein level of oxytocin receptor (OTR), while Gly increased OTR protein levels.	glyphosate	96-99	oxytocin receptor	Bos taurus	65-82
35193057-6	2022	Moreover, Atr decreased the mRNA expression and protein level of oxytocin receptor (OTR), while Gly increased OTR protein levels.	glyphosate	96-99	oxytocin receptor	Bos taurus	110-113
35377194-12	2022	Four regions, within the promoters of the MSH4, KCNA6, ABAT, and NDUFAF2/ERCC8 genes, were associated with glyphosate levels, along with an association between ESR1 promoter hypomethylation and AMPA.	glyphosate	107-117	mutS homolog 4	Homo sapiens	42-46
35377194-12	2022	Four regions, within the promoters of the MSH4, KCNA6, ABAT, and NDUFAF2/ERCC8 genes, were associated with glyphosate levels, along with an association between ESR1 promoter hypomethylation and AMPA.	glyphosate	107-117	potassium voltage-gated channel subfamily A member 6	Homo sapiens	48-53
35377194-12	2022	Four regions, within the promoters of the MSH4, KCNA6, ABAT, and NDUFAF2/ERCC8 genes, were associated with glyphosate levels, along with an association between ESR1 promoter hypomethylation and AMPA.	glyphosate	107-117	4-aminobutyrate aminotransferase	Homo sapiens	55-59
35377194-12	2022	Four regions, within the promoters of the MSH4, KCNA6, ABAT, and NDUFAF2/ERCC8 genes, were associated with glyphosate levels, along with an association between ESR1 promoter hypomethylation and AMPA.	glyphosate	107-117	NADH:ubiquinone oxidoreductase complex assembly factor 2	Homo sapiens	65-72
35377194-12	2022	Four regions, within the promoters of the MSH4, KCNA6, ABAT, and NDUFAF2/ERCC8 genes, were associated with glyphosate levels, along with an association between ESR1 promoter hypomethylation and AMPA.	glyphosate	107-117	ERCC excision repair 8, CSA ubiquitin ligase complex subunit	Homo sapiens	73-78
35284244-11	2022	The expression of the DNA methylation enzymes DNMT1, DNMT3A, and DNMT3B was measured in the small intestine, kidney, and liver of pigs exposed to glyphosate.	glyphosate	146-156	DNA methyltransferase 1	Sus scrofa	46-51
35284244-11	2022	The expression of the DNA methylation enzymes DNMT1, DNMT3A, and DNMT3B was measured in the small intestine, kidney, and liver of pigs exposed to glyphosate.	glyphosate	146-156	DNA methyltransferase 3 alpha	Sus scrofa	53-59
35284244-11	2022	The expression of the DNA methylation enzymes DNMT1, DNMT3A, and DNMT3B was measured in the small intestine, kidney, and liver of pigs exposed to glyphosate.	glyphosate	146-156	DNA methyltransferase 3 beta	Sus scrofa	65-71
35284244-13	2022	In contrast, a significant increase in expression of the enzyme TET3, responsible for demethylation, was observed in kidneys exposed to 200 ppm glyphosate.	glyphosate	144-154	tet methylcytosine dioxygenase 3	Sus scrofa	64-68
35239060-4	2022	Trace detection of glyphosate is possible with a wide detection range of 50-1300 ng mL-1 and spiked recoveries between 93.3 and 110.0%.	glyphosate	19-29	L1 cell adhesion molecule	Mus musculus	84-88
35269866-12	2022	The results demonstrated reduced sod1, sod2, and gpx1a in male following exposure to GLY, indicating an impaired oxidative stress response.	glyphosate	85-88	superoxide dismutase 1, soluble	Danio rerio	33-37
35269866-12	2022	The results demonstrated reduced sod1, sod2, and gpx1a in male following exposure to GLY, indicating an impaired oxidative stress response.	glyphosate	85-88	superoxide dismutase 2, mitochondrial	Danio rerio	39-43
35269866-12	2022	The results demonstrated reduced sod1, sod2, and gpx1a in male following exposure to GLY, indicating an impaired oxidative stress response.	glyphosate	85-88	glutathione peroxidase 1a	Danio rerio	49-54
6624478-5	1983	Glyphosate decreased the hepatic level of cytochrome P-450 and monooxygenase activities and the intestinal activity of aryl hydrocarbon hydroxylase.	glyphosate	0-10	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	119-147
35142761-0	2022	Fast, sensitive and selective simultaneous determination of paraquat and glyphosate herbicides in water samples using a compact electrochemical sensor.	glyphosate	73-83	Fas activated serine/threonine kinase	Homo sapiens	0-4
35193702-6	2022	We found that both glyphosate and tylosin decreased the expression of some antimicrobial peptides, such as apidaecin, defensin and hymenoptaecin, in exposed honey bees, but only glyphosate was able to inhibit melanization in the bee hemolymph.	glyphosate	19-29	hymenoptaecin	Apis mellifera	131-144
35204751-3	2022	To document the role of the ATM-dependent DSB repair and signaling after pesticide exposure, we applied six current pesticides of domestic and environmental interest (lindane, atrazine, glyphosate, permethrin, pentachlorophenol and thiabendazole) to human skin fibroblast and brain cells.	glyphosate	186-196	ATM serine/threonine kinase	Homo sapiens	28-31
24248252-6	1986	These results suggest that the glyphosate tolerance of the variant results from overaccumulation of a glyphosate-sensitive EPSP synthase.	glyphosate	31-41	3-phosphoshikimate 1-carboxyvinyltransferase, chloroplastic	Solanum lycopersicum	123-136
33837468-10	2021	Images revealed that Glyphosate treatment downregulates synapsin-1, PSD-95, and CaMKII expression, and also decreased PSD-95 clustering in hippocampus.	glyphosate	21-31	synapsin I	Rattus norvegicus	56-66
33837468-10	2021	Images revealed that Glyphosate treatment downregulates synapsin-1, PSD-95, and CaMKII expression, and also decreased PSD-95 clustering in hippocampus.	glyphosate	21-31	discs large MAGUK scaffold protein 4	Rattus norvegicus	68-74
33837468-10	2021	Images revealed that Glyphosate treatment downregulates synapsin-1, PSD-95, and CaMKII expression, and also decreased PSD-95 clustering in hippocampus.	glyphosate	21-31	discs large MAGUK scaffold protein 4	Rattus norvegicus	118-124
33503294-0	2021	Melatonin rescues the reproductive toxicity of low-dose glyphosate-based herbicide during mouse oocyte maturation via the GPER signaling pathway.	glyphosate	56-66	G protein-coupled estrogen receptor 1	Mus musculus	122-126
33853859-0	2021	An ABC transporter of the ABCC subfamily localized at the plasma membrane confers glyphosate resistance.	glyphosate	82-92	ATP binding cassette subfamily C member 1	Homo sapiens	26-30
33920750-7	2021	However, this response was not sufficient to maintain honey bee health, as glyphosate promoted the replication of DWV and decreased the expression of vitellogenin, which were accompanied by a reduced life span.	glyphosate	75-85	putative uncharacterized protein LOC400499	Homo sapiens	150-162
33957581-0	2021	Glyphosate exposure attenuates testosterone synthesis via NR1D1 inhibition of StAR expression in mouse Leydig cells.	glyphosate	0-10	nuclear receptor subfamily 1, group D, member 1	Mus musculus	58-63
33957581-0	2021	Glyphosate exposure attenuates testosterone synthesis via NR1D1 inhibition of StAR expression in mouse Leydig cells.	glyphosate	0-10	steroidogenic acute regulatory protein	Mus musculus	78-82
33957581-5	2021	However, whether NR1D1 is involved in the glyphosate-mediated inhibition of testosterone synthesis in LCs remains unclear.	glyphosate	42-52	nuclear receptor subfamily 1, group D, member 1	Mus musculus	17-22
33957581-6	2021	Here, the involvement of NR1D1 in glyphosate-mediated inhibition of testosterone synthesis was investigated both in vitro and in vivo.	glyphosate	34-44	nuclear receptor subfamily 1, group D, member 1	Mus musculus	25-30
33957581-7	2021	Glyphosate exposure of TM3 cells significantly increased Nr1d1 mRNA levels, but decreased Bmal1, Per2, StAR, Cyp11a1, and Cyp17a1 mRNA levels.	glyphosate	0-10	nuclear receptor subfamily 1, group D, member 1	Mus musculus	57-62
33957581-7	2021	Glyphosate exposure of TM3 cells significantly increased Nr1d1 mRNA levels, but decreased Bmal1, Per2, StAR, Cyp11a1, and Cyp17a1 mRNA levels.	glyphosate	0-10	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	90-95
33957581-7	2021	Glyphosate exposure of TM3 cells significantly increased Nr1d1 mRNA levels, but decreased Bmal1, Per2, StAR, Cyp11a1, and Cyp17a1 mRNA levels.	glyphosate	0-10	period circadian clock 2	Mus musculus	97-101
33957581-7	2021	Glyphosate exposure of TM3 cells significantly increased Nr1d1 mRNA levels, but decreased Bmal1, Per2, StAR, Cyp11a1, and Cyp17a1 mRNA levels.	glyphosate	0-10	steroidogenic acute regulatory protein	Mus musculus	103-107
33957581-7	2021	Glyphosate exposure of TM3 cells significantly increased Nr1d1 mRNA levels, but decreased Bmal1, Per2, StAR, Cyp11a1, and Cyp17a1 mRNA levels.	glyphosate	0-10	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	109-116
33957581-7	2021	Glyphosate exposure of TM3 cells significantly increased Nr1d1 mRNA levels, but decreased Bmal1, Per2, StAR, Cyp11a1, and Cyp17a1 mRNA levels.	glyphosate	0-10	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	122-129
33957581-8	2021	Western blotting confirmed elevated NR1D1 and reduced StAR protein levels following glyphosate exposure.	glyphosate	84-94	nuclear receptor subfamily 1, group D, member 1	Mus musculus	36-41
33957581-8	2021	Western blotting confirmed elevated NR1D1 and reduced StAR protein levels following glyphosate exposure.	glyphosate	84-94	steroidogenic acute regulatory protein	Mus musculus	54-58
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	nuclear receptor subfamily 1, group D, member 1	Mus musculus	53-58
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	aryl hydrocarbon receptor nuclear translocator-like	Mus musculus	127-132
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	period circadian clock 2	Mus musculus	137-141
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	steroidogenic acute regulatory protein	Mus musculus	168-172
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	174-181
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	cytochrome P450, family 11, subfamily a, polypeptide 1	Mus musculus	183-190
33957581-10	2021	In primary LCs, glyphosate exposure also upregulated Nr1d1 mRNA levels and downregulated the mRNA levels of other clock genes (Bmal1 and Per2) and steroidogenic genes (StAR, Cyp17a1, Cyp11a1, and Hsd3b2), and inhibited testosterone synthesis.	glyphosate	16-26	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Mus musculus	196-202
33957581-11	2021	Moreover, glyphosate exposure significantly reduced the amplitude and shortened the period of PER2::LUCIFERASE oscillations in primary LCs isolated from mPer2Luciferase knock-in mice.	glyphosate	10-20	period circadian clock 2	Mus musculus	94-98
33957581-11	2021	Moreover, glyphosate exposure significantly reduced the amplitude and shortened the period of PER2::LUCIFERASE oscillations in primary LCs isolated from mPer2Luciferase knock-in mice.	glyphosate	10-20	period circadian clock 2	Mus musculus	153-168
33957581-12	2021	Four weeks of oral glyphosate upregulated NR1D1 at both the mRNA and protein levels in mouse testes, and this was accompanied by a reduction in StAR expression.	glyphosate	19-29	nuclear receptor subfamily 1, group D, member 1	Mus musculus	42-47
33957581-12	2021	Four weeks of oral glyphosate upregulated NR1D1 at both the mRNA and protein levels in mouse testes, and this was accompanied by a reduction in StAR expression.	glyphosate	19-29	steroidogenic acute regulatory protein	Mus musculus	144-148
33957581-15	2021	Together, these data demonstrate that glyphosate perturbs testosterone synthesis via NR1D1 mediated inhibition of StAR expression in mouse LCs.	glyphosate	38-48	nuclear receptor subfamily 1, group D, member 1	Mus musculus	85-90
33957581-15	2021	Together, these data demonstrate that glyphosate perturbs testosterone synthesis via NR1D1 mediated inhibition of StAR expression in mouse LCs.	glyphosate	38-48	steroidogenic acute regulatory protein	Mus musculus	114-118
34052177-9	2021	A novel mechanism underlying the specificity of glyphosate for NHL, that is upregulation of the B-cell genome mutator enzyme activation-induced cytidine deaminase, has recently been demonstrated.	glyphosate	48-58	activation induced cytidine deaminase	Homo sapiens	125-162
33592801-9	2021	Assay on the 3D-muPAD can determine glyphosate by ImageJ detection, over an operating range of 0.005-50 mug mL-1 and with a detection limit of 0.002 mug mL-1.	glyphosate	36-46	L1 cell adhesion molecule	Mus musculus	108-112
33592801-9	2021	Assay on the 3D-muPAD can determine glyphosate by ImageJ detection, over an operating range of 0.005-50 mug mL-1 and with a detection limit of 0.002 mug mL-1.	glyphosate	36-46	L1 cell adhesion molecule	Mus musculus	153-157
31469339-5	2021	The degrading rate constant of glyphosate degradation was calculated to be kapp = 0.063 min-1.	glyphosate	31-41	CD59 molecule (CD59 blood group)	Homo sapiens	88-93
33848899-10	2021	Taken together, these results suggest that the combination of glyphosate and hard water, even at environmental exposure levels, enhances pyroptosis and ongoing tubulointerstitial inflammation through excessive Drp1-mediated mitochondrial fission.	glyphosate	62-72	dynamin 1-like	Mus musculus	210-214
33743019-3	2021	With the electroactive surface area is 1.7 times higher than that of bare SPAuE, the rGO/DWCNTs/Oct-Fe3O4/Cs/SPAuE for detection of GLY shows a low detection limit (LOD) of ~ 0.08 ppb in a large concentration range of 0.1-1000 ppb.	glyphosate	132-135	plexin A2	Homo sapiens	96-99
33245078-0	2021	Sensitive SERS assay for glyphosate based on the prevention of L-cysteine inhibition of a Au-Pt nanozyme.	glyphosate	25-35	seryl-tRNA synthetase 1	Homo sapiens	10-14
33346154-0	2021	Acetylcholinesterase (AChE) monoclonal antibody generation and validation for use as a biomarker of glyphosate-based herbicide exposure in commercial freshwater fish.	glyphosate	100-110	acetylcholinesterase	Oreochromis niloticus	22-26
33346154-1	2021	Monoclonal antibody specific to acetylcholinesterase (AChE) was extracted from the brain of hybrid catfish after exposure to glyphosate-based herbicide for 24 h. AChE was partially purified using hydroxyapatite and chromatography columns.	glyphosate	125-135	acetylcholinesterase	Mus musculus	54-58
33346154-10	2021	Moreover, AChE in Nile tilapia and climbing perch with glyphosate- based herbicide exposure gave a positive result with ACHE 33 as protein with molecular weight of 66 kDa.	glyphosate	55-65	acetylcholinesterase	Oreochromis niloticus	10-14
33346154-11	2021	Based on our results, the produced monoclonal antibody showed specificity and could be applied to test AChE expression to assess glyphosate-based herbicide contamination in hybrid catfish, Nile tilapia and climbing perch.	glyphosate	129-139	acetylcholinesterase	Mus musculus	103-107
33665035-13	2021	The surface runoff of dissolved Glyphosate was equal to 286 mg ha-1.	glyphosate	32-42	Rho GTPase activating protein 45	Homo sapiens	63-67
33245078-1	2021	Herein, an indirect SERS sensing assay was developed for the determination of glyphosate (Gly) in tap water.	glyphosate	78-88	seryl-tRNA synthetase 1	Homo sapiens	20-24
33245078-1	2021	Herein, an indirect SERS sensing assay was developed for the determination of glyphosate (Gly) in tap water.	glyphosate	90-93	seryl-tRNA synthetase 1	Homo sapiens	20-24
33245078-4	2021	Under optimal conditions, the SERS signal intensity of oxTMB (at 1605 cm-1) was proportional to the concentration of Gly.	glyphosate	117-120	seryl-tRNA synthetase 1	Homo sapiens	30-34
33245078-6	2021	The limit of detection and limit of quantitation of Gly were found to be 5 mug L-1 and 10 mug L-1, respectively.	glyphosate	52-55	L1 cell adhesion molecule	Homo sapiens	79-89
33245078-8	2021	This SERS assay can be used for detection of Gly in tap water that can meet the needs of practical detection.	glyphosate	45-48	seryl-tRNA synthetase 1	Homo sapiens	5-9
33348142-6	2021	Our results demonstrated that maximum permissible concentrations of glyphosate recognized by environmental protection authorities significantly reduced the cell migration and differentiation of NSCs as demonstrated by the downregulation of the expression levels of the neuronal ss-tubulin III and the astrocytic S100B genes.	glyphosate	68-78	S100 protein, beta polypeptide, neural	Mus musculus	312-317
32805371-0	2020	Exposure to glyphosate during pregnancy induces neurobehavioral alterations and downregulation of Wnt5a-CaMKII pathway.	glyphosate	12-22	Wnt family member 5A	Rattus norvegicus	98-103
32736223-4	2020	From the behavior of the modes corresponding to both internal modes and lattice modes it was possible to discovery two phase transitions undergone by glyphosate, one between 0.97 and 1.5 GPa and other in the pressure interval 4.29-4.63 GPa.	glyphosate	150-160	glycophorin A (MNS blood group)	Homo sapiens	187-190
32736223-4	2020	From the behavior of the modes corresponding to both internal modes and lattice modes it was possible to discovery two phase transitions undergone by glyphosate, one between 0.97 and 1.5 GPa and other in the pressure interval 4.29-4.63 GPa.	glyphosate	150-160	glycophorin A (MNS blood group)	Homo sapiens	236-239
33096666-1	2020	This article describes an optical method based on the association of surface plasmon resonance (SPR) with chitosan (CS) film and its nanocomposites, including zinc oxide (ZnO) or graphene oxide (GO) for glyphosate detection.	glyphosate	203-213	citrate synthase	Homo sapiens	116-118
33096666-5	2020	Results showed that the CS/ZnO thin-film composite provides the highest sensitivity for glyphosate sensing with a low detection limit of 8 nM and with high reproducibility.	glyphosate	88-98	citrate synthase	Homo sapiens	24-26
33159990-8	2021	Subsequently, our results showed that increased expression level of BAX protein, reduced expression of BCL-2 protein, ATG12 and LC3 protein expression increased in ovaries after Gly treatment.	glyphosate	178-181	BCL2-associated X protein	Mus musculus	68-71
33159990-8	2021	Subsequently, our results showed that increased expression level of BAX protein, reduced expression of BCL-2 protein, ATG12 and LC3 protein expression increased in ovaries after Gly treatment.	glyphosate	178-181	B cell leukemia/lymphoma 2	Mus musculus	103-108
33159990-8	2021	Subsequently, our results showed that increased expression level of BAX protein, reduced expression of BCL-2 protein, ATG12 and LC3 protein expression increased in ovaries after Gly treatment.	glyphosate	178-181	autophagy related 12	Mus musculus	118-123
33159990-8	2021	Subsequently, our results showed that increased expression level of BAX protein, reduced expression of BCL-2 protein, ATG12 and LC3 protein expression increased in ovaries after Gly treatment.	glyphosate	178-181	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	128-131
33569432-5	2021	Results: Administration of glyphosate in mice resulted in elevated levels of beta2-microglobulin (beta2-MG), albumin (ALB), and serum creatinine (SCr) compared to control mice.	glyphosate	27-37	beta-2 microglobulin	Mus musculus	77-96
33569432-5	2021	Results: Administration of glyphosate in mice resulted in elevated levels of beta2-microglobulin (beta2-MG), albumin (ALB), and serum creatinine (SCr) compared to control mice.	glyphosate	27-37	albumin	Mus musculus	109-116
33569432-5	2021	Results: Administration of glyphosate in mice resulted in elevated levels of beta2-microglobulin (beta2-MG), albumin (ALB), and serum creatinine (SCr) compared to control mice.	glyphosate	27-37	albumin	Mus musculus	118-121
33569432-9	2021	Immunofluorescence and western blot analyses showed that glyphosate and hard water had a coordinated effect on calcium ions (Ca2+)-activated phospholipase A2 and the activation may play a key role in inflammation and renal tubular injury.	glyphosate	57-67	phospholipase A2, group IB, pancreas	Mus musculus	141-157
33569432-10	2021	Exposure to glyphosate alone or glyphosate plus hard water increased the levels of oxidative stress markers and inflammatory biomarkers, namely, thromboxane A2 (TX-A2), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), nitric oxide synthase (NOS), and nitric oxide (NO).	glyphosate	12-22	nitric oxide synthase 1, neuronal	Mus musculus	217-238
33569432-10	2021	Exposure to glyphosate alone or glyphosate plus hard water increased the levels of oxidative stress markers and inflammatory biomarkers, namely, thromboxane A2 (TX-A2), leukotriene B4 (LTB4), prostaglandin E2 (PGE2), nitric oxide synthase (NOS), and nitric oxide (NO).	glyphosate	32-42	nitric oxide synthase 1, neuronal	Mus musculus	217-238
33569432-13	2021	Conclusions: These findings suggested that hard water combined with glyphosate can induce renal tubular injury in mice, and this may involve mitogen-activated protein kinases (MAPK)/cytosolic phospholipase A2 (cPLA2)/arachidonic acid (AA) and its downstream factors.	glyphosate	68-78	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	182-208
33569432-13	2021	Conclusions: These findings suggested that hard water combined with glyphosate can induce renal tubular injury in mice, and this may involve mitogen-activated protein kinases (MAPK)/cytosolic phospholipase A2 (cPLA2)/arachidonic acid (AA) and its downstream factors.	glyphosate	68-78	phospholipase A2, group IVA (cytosolic, calcium-dependent)	Mus musculus	210-215
32861895-5	2021	The results showed that treatments with higher Gly (4 and/16 mg/L) significantly increased the levels of TC, TG, AST, ALT, LDL-C and MDA, and apparently decreased the levels of SOD, GSH, CAT, HDL-C HK, G3PDH, FBPase and G6PD in serum, liver and/or gills.	glyphosate	47-50	superoxide dismutase [Mn], mitochondrial	Oreochromis niloticus	177-180
32861895-5	2021	The results showed that treatments with higher Gly (4 and/16 mg/L) significantly increased the levels of TC, TG, AST, ALT, LDL-C and MDA, and apparently decreased the levels of SOD, GSH, CAT, HDL-C HK, G3PDH, FBPase and G6PD in serum, liver and/or gills.	glyphosate	47-50	catalase	Oreochromis niloticus	187-190
32861895-6	2021	The gene expression data showed that the treatments with Gly adversely affected Nrf2 pathway in liver, gills and spleen, as shown by significant changes of nrf2, keap1, ho-1, nqo1 and gsta mRNA levels.	glyphosate	57-60	kelch-like ECH-associated protein 1	Oreochromis niloticus	162-167
32861895-6	2021	The gene expression data showed that the treatments with Gly adversely affected Nrf2 pathway in liver, gills and spleen, as shown by significant changes of nrf2, keap1, ho-1, nqo1 and gsta mRNA levels.	glyphosate	57-60	glutathione S-transferase	Oreochromis niloticus	184-188
32861895-8	2021	Moreover, the mRNA levels of cyp1a and cyp3a were upregulated in 16 or 0.2 mg/kg Gly group in liver.	glyphosate	81-84	cytochrome P450 1A	Oreochromis niloticus	29-34
32978654-6	2020	Under the optimum conditions, the fluorescence intensities of papain-AuNCs exhibited a good linear relationship with the concentration of Glyp in the range of 0.04-0.4 ng mL-1, and the limit of detection for Glyp was 0.035 ng mL-1.	glyphosate	138-142	L1 cell adhesion molecule	Mus musculus	171-175
32818823-7	2020	Histological studies and gene expression analyses examining markers of kidney development (pax2a) and kidney injury (kim1) showed novel metal and glyphosate-metal mixture specific effects on kidney development.	glyphosate	146-156	paired box 2a	Danio rerio	91-96
32818823-7	2020	Histological studies and gene expression analyses examining markers of kidney development (pax2a) and kidney injury (kim1) showed novel metal and glyphosate-metal mixture specific effects on kidney development.	glyphosate	146-156	hepatitis A virus cellular receptor 1	Danio rerio	117-121
32805371-8	2020	To go further, we evaluated whether prenatal exposure to glyphosate affected the Ca+2-mediated Wnt non-canonical signaling pathway.	glyphosate	57-67	carbonic anhydrase 2	Rattus norvegicus	81-85
32805371-8	2020	To go further, we evaluated whether prenatal exposure to glyphosate affected the Ca+2-mediated Wnt non-canonical signaling pathway.	glyphosate	57-67	Wnt family member 5A	Rattus norvegicus	95-98
32805371-10	2020	Taken together, these findings suggest that gestational exposure to glyphosate leads to a downregulation of Wnt/Ca+2 pathway that could induce a developmental neurotoxicity evidenced by deficits at behavioral and cognitive levels in rat pups.	glyphosate	68-78	Wnt family member 5A	Rattus norvegicus	108-111
32805371-10	2020	Taken together, these findings suggest that gestational exposure to glyphosate leads to a downregulation of Wnt/Ca+2 pathway that could induce a developmental neurotoxicity evidenced by deficits at behavioral and cognitive levels in rat pups.	glyphosate	68-78	carbonic anhydrase 2	Rattus norvegicus	112-116
32537734-3	2020	This observation formed the basis for the determination of glyphosate and glufosinate in the concentration ranges 0.34-8.45 mug mL-1 and 0.4-9.91 mug mL-1 respectively with correlation coefficient of 0.999.	glyphosate	59-69	L1 cell adhesion molecule	Mus musculus	128-132
32659957-5	2020	The electrochemical behavior of CoII@SiO2 is manifested by one oxidation and two reduction steps, which provide the basis for electrochemical response on glyphosate and HP(O)(OEt)2 with the LOD = 0.1 muM and the linearity within 0.1-80 muM.	glyphosate	154-164	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-36
32659957-6	2020	The Stober CoII@SiO2 are able to discriminate glyphosate from HP(O)(OEt)2, while the w/o nanoparticles are more efficient but nonselective sensors on the toxicants.	glyphosate	46-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	11-15
32733492-0	2020	Transgenic Cotton (Gossypium hirsutum L.) to Combat Weed Vagaries: Utility of an Apical Meristem-Targeted in planta Transformation Strategy to Introgress a Modified CP4-EPSPS Gene for Glyphosate Tolerance.	glyphosate	184-194	3-phosphoshikimate 1-carboxyvinyltransferase 2	Gossypium hirsutum	169-174
32733492-2	2020	Glyphosate [N-(phosphonomethyl)glycine] is a widely used broad spectrum non-selective herbicide that controls weeds by inhibiting 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme and interfering with the shikimate biosynthesis pathway.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 2	Gossypium hirsutum	175-180
32733492-2	2020	Glyphosate [N-(phosphonomethyl)glycine] is a widely used broad spectrum non-selective herbicide that controls weeds by inhibiting 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) enzyme and interfering with the shikimate biosynthesis pathway.	glyphosate	12-38	3-phosphoshikimate 1-carboxyvinyltransferase 2	Gossypium hirsutum	175-180
32537734-3	2020	This observation formed the basis for the determination of glyphosate and glufosinate in the concentration ranges 0.34-8.45 mug mL-1 and 0.4-9.91 mug mL-1 respectively with correlation coefficient of 0.999.	glyphosate	59-69	L1 cell adhesion molecule	Mus musculus	150-154
32387710-3	2020	In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (DAT) in the striatum and tyrosine hydroxylase (TH) in the substantial nigra (SNr) of mouse brain after repeated administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	glyphosate	51-61	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	90-110
32387710-3	2020	In this study, we examined whether the exposure of glyphosate can affect the reduction of dopamine transporter (DAT) in the striatum and tyrosine hydroxylase (TH) in the substantial nigra (SNr) of mouse brain after repeated administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).	glyphosate	51-61	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	112-115
32247958-5	2020	The highest glyphosate concentration prevented copepods from reaching the adult stage, inhibited the growth of the first copepodite stage and increased the GST and SOD activity in adult females.	glyphosate	12-22	glutathione S-transferase kappa 1	Homo sapiens	156-159
32247958-5	2020	The highest glyphosate concentration prevented copepods from reaching the adult stage, inhibited the growth of the first copepodite stage and increased the GST and SOD activity in adult females.	glyphosate	12-22	superoxide dismutase 1	Homo sapiens	164-167
32360565-0	2020	Glyphosate induces epithelial mesenchymal transition-related changes in human endometrial Ishikawa cells via estrogen receptor pathway.	glyphosate	0-10	estrogen receptor 1	Homo sapiens	109-126
32360565-5	2020	Moreover, a down regulation of E-cadherin mRNA expression was determined in response to Gly, similar to E2-effects.	glyphosate	88-91	cadherin 1	Homo sapiens	31-41
32360565-7	2020	When an ER antagonist (Fulvestrant: 10-7 M) was co-administrated with Gly, all changes were reversed, suggesting that Gly might promote EMT-related changes via ER-dependent pathway.	glyphosate	70-73	estrogen receptor 1	Homo sapiens	8-10
32360565-7	2020	When an ER antagonist (Fulvestrant: 10-7 M) was co-administrated with Gly, all changes were reversed, suggesting that Gly might promote EMT-related changes via ER-dependent pathway.	glyphosate	70-73	estrogen receptor 1	Homo sapiens	160-162
32360565-7	2020	When an ER antagonist (Fulvestrant: 10-7 M) was co-administrated with Gly, all changes were reversed, suggesting that Gly might promote EMT-related changes via ER-dependent pathway.	glyphosate	118-121	estrogen receptor 1	Homo sapiens	8-10
32360565-7	2020	When an ER antagonist (Fulvestrant: 10-7 M) was co-administrated with Gly, all changes were reversed, suggesting that Gly might promote EMT-related changes via ER-dependent pathway.	glyphosate	118-121	estrogen receptor 1	Homo sapiens	160-162
32360565-8	2020	Our results are interesting evidences of Gly effects on endometrial cancer progression via the ER-dependent pathway.	glyphosate	41-44	estrogen receptor 1	Homo sapiens	95-97
32398374-0	2020	Maternal glyphosate exposure causes autism-like behaviors in offspring through increased expression of soluble epoxide hydrolase.	glyphosate	9-19	epoxide hydrolase 2	Homo sapiens	103-128
32045792-8	2020	In addition, the mRNA expression levels of IL-1beta, IL-6, TNF-alpha, MAPK3, NF-kappaB, and Caspase-3 were increased after glyphosate exposure.	glyphosate	123-133	interleukin 1 alpha	Rattus norvegicus	43-51
32045792-8	2020	In addition, the mRNA expression levels of IL-1beta, IL-6, TNF-alpha, MAPK3, NF-kappaB, and Caspase-3 were increased after glyphosate exposure.	glyphosate	123-133	interleukin 6	Rattus norvegicus	53-57
32045792-8	2020	In addition, the mRNA expression levels of IL-1beta, IL-6, TNF-alpha, MAPK3, NF-kappaB, and Caspase-3 were increased after glyphosate exposure.	glyphosate	123-133	tumor necrosis factor	Rattus norvegicus	59-68
32045792-8	2020	In addition, the mRNA expression levels of IL-1beta, IL-6, TNF-alpha, MAPK3, NF-kappaB, and Caspase-3 were increased after glyphosate exposure.	glyphosate	123-133	mitogen activated protein kinase 3	Rattus norvegicus	70-75
32045792-8	2020	In addition, the mRNA expression levels of IL-1beta, IL-6, TNF-alpha, MAPK3, NF-kappaB, and Caspase-3 were increased after glyphosate exposure.	glyphosate	123-133	caspase 3	Rattus norvegicus	92-101
32315717-7	2020	Our work shows for the first time that glyphosate exposure impairs metaphase II mouse oocyte quality via two mechanisms: 1) disruption of the microtubule organizing center and chromosomes such as anomalous pericentrin formation, spindle fiber destruction and disappearance, and defective chromosomal alignment and 2) substantial depletion of intracellular zinc bioavailability and enhancement of reactive oxygen species accumulation.	glyphosate	39-49	pericentrin (kendrin)	Mus musculus	206-217
32398374-7	2020	Interestingly, oral administration of TPPU (an sEH inhibitor) to pregnant mothers from E5 to P21 prevented ASD-like behaviors such as social interaction deficits and increased grooming time in the juvenile offspring after maternal glyphosate exposure.	glyphosate	231-241	epoxide hydrolase 2	Homo sapiens	47-50
32398374-8	2020	These findings suggest that maternal exposure to high levels of glyphosate causes ASD-like behavioral abnormalities and abnormal composition of gut microbiota in juvenile offspring, and that increased activity of sEH might play a role in ASD-like behaviors in offspring after maternal glyphosate exposure.	glyphosate	285-295	epoxide hydrolase 2	Homo sapiens	213-216
32444888-7	2020	Under optimal conditions, the turn-on nanoprobe showed a linear relationship between fluorescent response and glyphosate concentrations in the range 0.1 to 1 mug mL-1.	glyphosate	110-120	L1 cell adhesion molecule	Mus musculus	162-166
31968290-9	2020	Treatment TM3 cells with glyphosate at 5 mg/L not only reduced the protein levels of testosterone synthase StAR and CYP17A1, inhibited testosterone secretion, but also increased the protein level of ER stress molecule Bip and promoted the phosphorylation of PERK and eIF2alpha.	glyphosate	25-35	steroidogenic acute regulatory protein	Mus musculus	107-111
31968290-9	2020	Treatment TM3 cells with glyphosate at 5 mg/L not only reduced the protein levels of testosterone synthase StAR and CYP17A1, inhibited testosterone secretion, but also increased the protein level of ER stress molecule Bip and promoted the phosphorylation of PERK and eIF2alpha.	glyphosate	25-35	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	116-123
31968290-9	2020	Treatment TM3 cells with glyphosate at 5 mg/L not only reduced the protein levels of testosterone synthase StAR and CYP17A1, inhibited testosterone secretion, but also increased the protein level of ER stress molecule Bip and promoted the phosphorylation of PERK and eIF2alpha.	glyphosate	25-35	heat shock protein 5	Mus musculus	218-221
31968290-9	2020	Treatment TM3 cells with glyphosate at 5 mg/L not only reduced the protein levels of testosterone synthase StAR and CYP17A1, inhibited testosterone secretion, but also increased the protein level of ER stress molecule Bip and promoted the phosphorylation of PERK and eIF2alpha.	glyphosate	25-35	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	258-262
31968290-9	2020	Treatment TM3 cells with glyphosate at 5 mg/L not only reduced the protein levels of testosterone synthase StAR and CYP17A1, inhibited testosterone secretion, but also increased the protein level of ER stress molecule Bip and promoted the phosphorylation of PERK and eIF2alpha.	glyphosate	25-35	eukaryotic translation initiation factor 2A	Mus musculus	267-276
31968290-10	2020	Pretreatment cells with PBA, an inhibitor of ER stress, alleviated glyphosate-induced increase in Bip, p-PERK and p-eIF2alpha protein levels, meanwhile rescuing glyphosate-induced testosterone synthesis disorders.	glyphosate	67-77	heat shock protein 5	Mus musculus	98-101
31968290-10	2020	Pretreatment cells with PBA, an inhibitor of ER stress, alleviated glyphosate-induced increase in Bip, p-PERK and p-eIF2alpha protein levels, meanwhile rescuing glyphosate-induced testosterone synthesis disorders.	glyphosate	67-77	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	105-109
31968290-10	2020	Pretreatment cells with PBA, an inhibitor of ER stress, alleviated glyphosate-induced increase in Bip, p-PERK and p-eIF2alpha protein levels, meanwhile rescuing glyphosate-induced testosterone synthesis disorders.	glyphosate	67-77	eukaryotic translation initiation factor 2A	Mus musculus	116-125
31968290-12	2020	Overall, our findings suggest that glyphosate can interfere with the expression of StAR and CYP17A1 and inhibit testosterone synthesis and secretion via ER stress-mediated the activation of PERK/eIF2alpha signaling pathway in Leydig cells.	glyphosate	35-45	steroidogenic acute regulatory protein	Mus musculus	83-87
31968290-12	2020	Overall, our findings suggest that glyphosate can interfere with the expression of StAR and CYP17A1 and inhibit testosterone synthesis and secretion via ER stress-mediated the activation of PERK/eIF2alpha signaling pathway in Leydig cells.	glyphosate	35-45	cytochrome P450, family 17, subfamily a, polypeptide 1	Mus musculus	92-99
31968290-12	2020	Overall, our findings suggest that glyphosate can interfere with the expression of StAR and CYP17A1 and inhibit testosterone synthesis and secretion via ER stress-mediated the activation of PERK/eIF2alpha signaling pathway in Leydig cells.	glyphosate	35-45	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	190-194
31968290-12	2020	Overall, our findings suggest that glyphosate can interfere with the expression of StAR and CYP17A1 and inhibit testosterone synthesis and secretion via ER stress-mediated the activation of PERK/eIF2alpha signaling pathway in Leydig cells.	glyphosate	35-45	eukaryotic translation initiation factor 2A	Mus musculus	195-204
32144705-9	2020	Furthermore, inhibition of CYP1A4 in the duodenum, CYP1A4, and MRP2 in the jejunum in embryos exposed to glyphosate or Roundup .	glyphosate	105-115	cytochrome P450 1A4	Gallus gallus	27-33
32144705-10	2020	In addition, glyphosate treatment caused an increase of CYP3A5, CYP1C1, and IFNY mRNA expression in the jejunum and CYP1A2 expression in the ileum, while IFN-Y gene increase in embryos treated with Roundup .	glyphosate	13-23	cytochrome P450, family 1, subfamily C, polypeptide 1	Gallus gallus	64-70
32144705-10	2020	In addition, glyphosate treatment caused an increase of CYP3A5, CYP1C1, and IFNY mRNA expression in the jejunum and CYP1A2 expression in the ileum, while IFN-Y gene increase in embryos treated with Roundup .	glyphosate	13-23	cytochrome P450 1A2	Gallus gallus	116-122
31968290-11	2020	When pretreatment with GSK2606414, a PERK inhibitor, the glyphosate-induced phosphorylation of PERK and eIF2alpha was blocked, and the glyphosate-inhibited testosterone synthesis and secretion was also restored.	glyphosate	57-67	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	37-41
31968290-11	2020	When pretreatment with GSK2606414, a PERK inhibitor, the glyphosate-induced phosphorylation of PERK and eIF2alpha was blocked, and the glyphosate-inhibited testosterone synthesis and secretion was also restored.	glyphosate	57-67	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	95-99
31968290-11	2020	When pretreatment with GSK2606414, a PERK inhibitor, the glyphosate-induced phosphorylation of PERK and eIF2alpha was blocked, and the glyphosate-inhibited testosterone synthesis and secretion was also restored.	glyphosate	57-67	eukaryotic translation initiation factor 2A	Mus musculus	104-113
31968290-11	2020	When pretreatment with GSK2606414, a PERK inhibitor, the glyphosate-induced phosphorylation of PERK and eIF2alpha was blocked, and the glyphosate-inhibited testosterone synthesis and secretion was also restored.	glyphosate	135-145	eukaryotic translation initiation factor 2 alpha kinase 3	Mus musculus	37-41
31776084-0	2020	Toxicity of glyphosate in feed for weanling piglets and the mechanism of glyphosate detoxification by the liver nuclear receptor CAR/PXR pathway.	glyphosate	73-83	CXADR pseudogene 1	Homo sapiens	129-132
31776084-0	2020	Toxicity of glyphosate in feed for weanling piglets and the mechanism of glyphosate detoxification by the liver nuclear receptor CAR/PXR pathway.	glyphosate	73-83	nuclear receptor subfamily 1 group I member 2	Homo sapiens	133-136
32050978-7	2020	The strongest evidence shows that glyphosate causes hemangiosarcomas, kidney tumors and malignant lymphomas in male CD-1 mice, hemangiomas and malignant lymphomas in female CD-1 mice, hemangiomas in female Swiss albino mice, kidney adenomas, liver adenomas, skin keratoacanthomas and skin basal cell tumors in male Sprague-Dawley rats, adrenal cortical carcinomas in female Sprague-Dawley rats and hepatocellular adenomas and skin keratocanthomas in male Wistar rats.	glyphosate	34-44	CD1 antigen complex	Mus musculus	116-120
31169038-1	2020	Context: During the re-approval process of glyphosate in Europe, it was mentioned that glyphosate-based products (GBF) were more toxic than glyphosate alone.	glyphosate	43-53	Kruppel like factor 6	Homo sapiens	114-117
31169038-1	2020	Context: During the re-approval process of glyphosate in Europe, it was mentioned that glyphosate-based products (GBF) were more toxic than glyphosate alone.	glyphosate	87-97	Kruppel like factor 6	Homo sapiens	114-117
31169038-1	2020	Context: During the re-approval process of glyphosate in Europe, it was mentioned that glyphosate-based products (GBF) were more toxic than glyphosate alone.	glyphosate	87-97	Kruppel like factor 6	Homo sapiens	114-117
31751608-7	2020	Glyphosate decreased expression of P16 and TP53 as well as an increase in the expression of BCl2, CCND1 and P21.	glyphosate	0-10	cyclin dependent kinase inhibitor 2A	Homo sapiens	35-38
31751608-7	2020	Glyphosate decreased expression of P16 and TP53 as well as an increase in the expression of BCl2, CCND1 and P21.	glyphosate	0-10	tumor protein p53	Homo sapiens	43-47
31751608-7	2020	Glyphosate decreased expression of P16 and TP53 as well as an increase in the expression of BCl2, CCND1 and P21.	glyphosate	0-10	BCL2 apoptosis regulator	Homo sapiens	92-96
31751608-7	2020	Glyphosate decreased expression of P16 and TP53 as well as an increase in the expression of BCl2, CCND1 and P21.	glyphosate	0-10	cyclin D1	Homo sapiens	98-103
31751608-7	2020	Glyphosate decreased expression of P16 and TP53 as well as an increase in the expression of BCl2, CCND1 and P21.	glyphosate	0-10	H3 histone pseudogene 16	Homo sapiens	108-111
32208468-9	2020	The fluorescence quenching property of carbon dots has been utilized to identify detection limit of 0.25, 0.5, and 2 ng ml-1 for diazinon, amicarbazone, and glyphosate, respectively.	glyphosate	157-167	interleukin 17F	Homo sapiens	120-124
31836050-0	2020	Correlation between CYP1A1 polymorphisms and susceptibility to glyphosate-induced reduction of serum cholinesterase: A case-control study of a Chinese population.	glyphosate	63-73	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	20-26
32014006-11	2020	Downregulation of miR-299-5p expression attenuated the inhibition of the proliferation and metastasis of non-small cell lung cancer cells by GPF treatment.	glyphosate	141-144	microRNA 299a	Mus musculus	18-25
31874349-8	2020	Glyphosate (5 mM) and AMPA (10 mM) induced a significant increase in MDA levels, NO and ROS production and caspase 3/7 activity.	glyphosate	0-10	caspase 3	Homo sapiens	107-116
31874349-9	2020	Glyphosate exposure induced up-regulation of Wnt3a, Wnt5a, Wnt7a, CAMK2A, CAMK2B and down-regulation of GAP43 and TUBB3 mRNA expression involved in normal neural cell development.	glyphosate	0-10	Wnt family member 3A	Homo sapiens	45-50
31874349-9	2020	Glyphosate exposure induced up-regulation of Wnt3a, Wnt5a, Wnt7a, CAMK2A, CAMK2B and down-regulation of GAP43 and TUBB3 mRNA expression involved in normal neural cell development.	glyphosate	0-10	Wnt family member 5A	Homo sapiens	52-57
31874349-9	2020	Glyphosate exposure induced up-regulation of Wnt3a, Wnt5a, Wnt7a, CAMK2A, CAMK2B and down-regulation of GAP43 and TUBB3 mRNA expression involved in normal neural cell development.	glyphosate	0-10	Wnt family member 7A	Homo sapiens	59-64
31874349-9	2020	Glyphosate exposure induced up-regulation of Wnt3a, Wnt5a, Wnt7a, CAMK2A, CAMK2B and down-regulation of GAP43 and TUBB3 mRNA expression involved in normal neural cell development.	glyphosate	0-10	calcium/calmodulin dependent protein kinase II alpha	Homo sapiens	66-72
31874349-9	2020	Glyphosate exposure induced up-regulation of Wnt3a, Wnt5a, Wnt7a, CAMK2A, CAMK2B and down-regulation of GAP43 and TUBB3 mRNA expression involved in normal neural cell development.	glyphosate	0-10	calcium/calmodulin dependent protein kinase II beta	Homo sapiens	74-80
31874349-9	2020	Glyphosate exposure induced up-regulation of Wnt3a, Wnt5a, Wnt7a, CAMK2A, CAMK2B and down-regulation of GAP43 and TUBB3 mRNA expression involved in normal neural cell development.	glyphosate	0-10	growth associated protein 43	Homo sapiens	104-109
31874349-9	2020	Glyphosate exposure induced up-regulation of Wnt3a, Wnt5a, Wnt7a, CAMK2A, CAMK2B and down-regulation of GAP43 and TUBB3 mRNA expression involved in normal neural cell development.	glyphosate	0-10	tubulin beta 3 class III	Homo sapiens	114-119
31874349-10	2020	In relation to gene expression profiling of cell death pathways, of the 84 genes examined in cells a greater than 2-fold change was observed for APAF1, BAX, BCL2, CASP3, CASP7, CASP9, SYCP2, TNF, TP53, CTSB, NFkappaB1, PIK3C3, SNCA, SQSTMT, HSPBAP1 and KCNIPI mRNA expression for glyphosate and AMPA exposures.	glyphosate	280-290	apoptotic peptidase activating factor 1	Homo sapiens	145-150
31874349-10	2020	In relation to gene expression profiling of cell death pathways, of the 84 genes examined in cells a greater than 2-fold change was observed for APAF1, BAX, BCL2, CASP3, CASP7, CASP9, SYCP2, TNF, TP53, CTSB, NFkappaB1, PIK3C3, SNCA, SQSTMT, HSPBAP1 and KCNIPI mRNA expression for glyphosate and AMPA exposures.	glyphosate	280-290	BCL2 associated X, apoptosis regulator	Homo sapiens	152-155
31874349-10	2020	In relation to gene expression profiling of cell death pathways, of the 84 genes examined in cells a greater than 2-fold change was observed for APAF1, BAX, BCL2, CASP3, CASP7, CASP9, SYCP2, TNF, TP53, CTSB, NFkappaB1, PIK3C3, SNCA, SQSTMT, HSPBAP1 and KCNIPI mRNA expression for glyphosate and AMPA exposures.	glyphosate	280-290	BCL2 apoptosis regulator	Homo sapiens	157-161
31874349-10	2020	In relation to gene expression profiling of cell death pathways, of the 84 genes examined in cells a greater than 2-fold change was observed for APAF1, BAX, BCL2, CASP3, CASP7, CASP9, SYCP2, TNF, TP53, CTSB, NFkappaB1, PIK3C3, SNCA, SQSTMT, HSPBAP1 and KCNIPI mRNA expression for glyphosate and AMPA exposures.	glyphosate	280-290	caspase 3	Homo sapiens	163-168
31874349-10	2020	In relation to gene expression profiling of cell death pathways, of the 84 genes examined in cells a greater than 2-fold change was observed for APAF1, BAX, BCL2, CASP3, CASP7, CASP9, SYCP2, TNF, TP53, CTSB, NFkappaB1, PIK3C3, SNCA, SQSTMT, HSPBAP1 and KCNIPI mRNA expression for glyphosate and AMPA exposures.	glyphosate	280-290	caspase 7	Homo sapiens	170-175
31874349-10	2020	In relation to gene expression profiling of cell death pathways, of the 84 genes examined in cells a greater than 2-fold change was observed for APAF1, BAX, BCL2, CASP3, CASP7, CASP9, SYCP2, TNF, TP53, CTSB, NFkappaB1, PIK3C3, SNCA, SQSTMT, HSPBAP1 and KCNIPI mRNA expression for glyphosate and AMPA exposures.	glyphosate	280-290	tumor necrosis factor	Homo sapiens	191-194
32019089-16	2020	Taking into account the variability of response among populations, it was established that the optimal dose of glyphosate to control Lolium spp.	glyphosate	111-121	histocompatibility minor 13	Homo sapiens	140-143
31677563-8	2020	In the duodenum, glyphosate remarkably increased the relative mRNA expression levels of Nrf2 (linear and quadratic, P < 0.05) and NQO1 (linear and quadratic, P < 0.05) and reduced the relative mRNA expression levels of GPx1, HO-1 and GCLM (linear and quadratic, P < 0.05).	glyphosate	17-27	NFE2 like bZIP transcription factor 2	Homo sapiens	88-92
31677563-8	2020	In the duodenum, glyphosate remarkably increased the relative mRNA expression levels of Nrf2 (linear and quadratic, P < 0.05) and NQO1 (linear and quadratic, P < 0.05) and reduced the relative mRNA expression levels of GPx1, HO-1 and GCLM (linear and quadratic, P < 0.05).	glyphosate	17-27	NAD(P)H quinone dehydrogenase 1	Homo sapiens	133-137
31677563-8	2020	In the duodenum, glyphosate remarkably increased the relative mRNA expression levels of Nrf2 (linear and quadratic, P < 0.05) and NQO1 (linear and quadratic, P < 0.05) and reduced the relative mRNA expression levels of GPx1, HO-1 and GCLM (linear and quadratic, P < 0.05).	glyphosate	17-27	glutathione peroxidase 1	Homo sapiens	225-229
31677563-8	2020	In the duodenum, glyphosate remarkably increased the relative mRNA expression levels of Nrf2 (linear and quadratic, P < 0.05) and NQO1 (linear and quadratic, P < 0.05) and reduced the relative mRNA expression levels of GPx1, HO-1 and GCLM (linear and quadratic, P < 0.05).	glyphosate	17-27	heme oxygenase 1	Homo sapiens	231-235
31677563-8	2020	In the duodenum, glyphosate remarkably increased the relative mRNA expression levels of Nrf2 (linear and quadratic, P < 0.05) and NQO1 (linear and quadratic, P < 0.05) and reduced the relative mRNA expression levels of GPx1, HO-1 and GCLM (linear and quadratic, P < 0.05).	glyphosate	17-27	glutamate-cysteine ligase modifier subunit	Homo sapiens	240-244
31677563-9	2020	In the jejunum, glyphosate remarkably increased the relative mRNA expression levels of Nrf2 (linear and quadratic, P < 0.05) and decreased the relative mRNA expression levels of GCLM (linear and quadratic, P < 0.05).	glyphosate	16-26	NFE2 like bZIP transcription factor 2	Homo sapiens	87-91
31677563-9	2020	In the jejunum, glyphosate remarkably increased the relative mRNA expression levels of Nrf2 (linear and quadratic, P < 0.05) and decreased the relative mRNA expression levels of GCLM (linear and quadratic, P < 0.05).	glyphosate	16-26	glutamate-cysteine ligase modifier subunit	Homo sapiens	181-185
31677563-12	2020	Additionally, the results demonstrated that glyphosate linearly decreased the ZO-1 mRNA expression levels in the jejunum and the mRNA expression of claudin-1 in the duodenum (P < 0.05).	glyphosate	44-54	tight junction protein 1	Homo sapiens	78-82
31677563-12	2020	Additionally, the results demonstrated that glyphosate linearly decreased the ZO-1 mRNA expression levels in the jejunum and the mRNA expression of claudin-1 in the duodenum (P < 0.05).	glyphosate	44-54	claudin 1	Homo sapiens	148-157
31677563-13	2020	In the duodenum, glyphosate increased the protein expression levels of Nrf2 (linear, P = 0.025).	glyphosate	17-27	NFE2 like bZIP transcription factor 2	Homo sapiens	71-75
32586204-5	2020	LOQs for AMPA, glyphosate and glufosinate were established at 0.5, 0.2 and 0.3 mug L-1, respectively.	glyphosate	15-25	TARBP2 subunit of RISC loading complex	Homo sapiens	0-4
31778134-0	2020	Thermal decomposition kinetics of glyphosate (GP) and its metabolite aminomethylphosphonic acid (AMPA).	glyphosate	34-44	ring finger protein 130	Homo sapiens	46-48
31778134-1	2020	Glyphosate (GP) is a widely used herbicide worldwide, yet accumulation of GP and its main byproduct, aminomethylphosphonic acid (AMPA), in soil and water has raised concerns about its potential effects on human health.	glyphosate	0-10	ring finger protein 130	Homo sapiens	12-14
31778134-1	2020	Glyphosate (GP) is a widely used herbicide worldwide, yet accumulation of GP and its main byproduct, aminomethylphosphonic acid (AMPA), in soil and water has raised concerns about its potential effects on human health.	glyphosate	0-10	ring finger protein 130	Homo sapiens	74-76
32107966-5	2020	The validation certified that the method was precise, accurate, linear, and selective, with a limit of quantification of 1.09 and 0.29 mug L-1 for glyphosate and AMPA, respectively.	glyphosate	147-157	immunoglobulin kappa variable 1-16	Homo sapiens	139-142
31836050-0	2020	Correlation between CYP1A1 polymorphisms and susceptibility to glyphosate-induced reduction of serum cholinesterase: A case-control study of a Chinese population.	glyphosate	63-73	butyrylcholinesterase	Homo sapiens	101-115
31836050-2	2020	The serum cholinesterase (ChE) may be affected when exposed to glyphosate.	glyphosate	63-73	butyrylcholinesterase	Homo sapiens	10-24
31836050-2	2020	The serum cholinesterase (ChE) may be affected when exposed to glyphosate.	glyphosate	63-73	butyrylcholinesterase	Homo sapiens	26-29
31556601-7	2019	Finally, the proposed chemosensor was subjected to glyphosate samples (commercial herbicide and tap water samples) and produced satisfactory results.	glyphosate	51-61	nuclear RNA export factor 1	Homo sapiens	96-99
31352102-5	2019	Reactive oxygen species (ROS) were found in mouse oocytes exposed to glyphosate, as shown by changes in the mRNA expression of related antioxidant enzyme genes (cat, sod2, gpx).	glyphosate	69-79	superoxide dismutase 2, mitochondrial	Mus musculus	166-170
31352102-5	2019	Reactive oxygen species (ROS) were found in mouse oocytes exposed to glyphosate, as shown by changes in the mRNA expression of related antioxidant enzyme genes (cat, sod2, gpx).	glyphosate	69-79	peroxiredoxin 6 pseudogene 2	Mus musculus	172-175
31352102-9	2019	Meanwhile, the expression levels of autophagy-related genes (lc3, atg14, mtor) and proteins (LC3, Atg12) were significantly decreased in the glyphosate treatment group compared with the control group.	glyphosate	141-151	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	61-64
31352102-9	2019	Meanwhile, the expression levels of autophagy-related genes (lc3, atg14, mtor) and proteins (LC3, Atg12) were significantly decreased in the glyphosate treatment group compared with the control group.	glyphosate	141-151	autophagy related 14	Mus musculus	66-71
31352102-9	2019	Meanwhile, the expression levels of autophagy-related genes (lc3, atg14, mtor) and proteins (LC3, Atg12) were significantly decreased in the glyphosate treatment group compared with the control group.	glyphosate	141-151	mechanistic target of rapamycin kinase	Mus musculus	73-77
31352102-9	2019	Meanwhile, the expression levels of autophagy-related genes (lc3, atg14, mtor) and proteins (LC3, Atg12) were significantly decreased in the glyphosate treatment group compared with the control group.	glyphosate	141-151	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	93-96
31352102-9	2019	Meanwhile, the expression levels of autophagy-related genes (lc3, atg14, mtor) and proteins (LC3, Atg12) were significantly decreased in the glyphosate treatment group compared with the control group.	glyphosate	141-151	autophagy related 12	Mus musculus	98-103
31338597-7	2019	maritima suggested that the enzyme showed powerful competitive binding capacity of PEP over glyphosate and high glyphosate tolerance.	glyphosate	92-102	RNA-binding KH domain-containing protein	Arabidopsis thaliana	83-86
31338597-7	2019	maritima suggested that the enzyme showed powerful competitive binding capacity of PEP over glyphosate and high glyphosate tolerance.	glyphosate	112-122	RNA-binding KH domain-containing protein	Arabidopsis thaliana	83-86
31453655-7	2019	Furthermore, oxidative stress was observed in the treated chicks, the glyphosate and Roundup  induced changes of the content of malondialdehyde in both the liver and kidney, moreover decrease of glutathione peroxidase, total superoxide dismutase and catalase activity in the kidney tissue and serum.	glyphosate	70-80	catalase	Gallus gallus	250-258
31485762-6	2019	The glyphosate associated with TSP in the rural zone presented levels between 0.002 and 0.144 mug/m3 (mean of 0.055 mug/m3) and the atmospheric TSP (gas phase) showed levels between 0.313 and 2.939 mug/m3 (average of 1.218 mug/m3).	glyphosate	4-14	thrombospondin 1	Homo sapiens	31-34
31611907-9	2019	Culture of primary cells from resected tumors revealed a luminal B (ER+/PR-/HER2-) phenotype in response to glyphosate-miR182-5p exposure with sensitivity to tamoxifen and invasive and migratory potentials.	glyphosate	108-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-80
31611907-11	2019	Looking for potential epigenetic marks of TET-mediated gene regulation under glyphosate exposure, we identified MTRNR2L2 and DUX4 genes, the hypomethylation of which was sustained even after stopping glyphosate exposure for 6 weeks.	glyphosate	77-87	MT-RNR2 like 2 (pseudogene)	Homo sapiens	112-120
31611907-11	2019	Looking for potential epigenetic marks of TET-mediated gene regulation under glyphosate exposure, we identified MTRNR2L2 and DUX4 genes, the hypomethylation of which was sustained even after stopping glyphosate exposure for 6 weeks.	glyphosate	77-87	double homeobox 4	Homo sapiens	125-129
31611907-11	2019	Looking for potential epigenetic marks of TET-mediated gene regulation under glyphosate exposure, we identified MTRNR2L2 and DUX4 genes, the hypomethylation of which was sustained even after stopping glyphosate exposure for 6 weeks.	glyphosate	200-210	MT-RNR2 like 2 (pseudogene)	Homo sapiens	112-120
31611907-11	2019	Looking for potential epigenetic marks of TET-mediated gene regulation under glyphosate exposure, we identified MTRNR2L2 and DUX4 genes, the hypomethylation of which was sustained even after stopping glyphosate exposure for 6 weeks.	glyphosate	200-210	double homeobox 4	Homo sapiens	125-129
31485762-7	2019	The glyphosate associated with TSP in the urban zone ranged from 0.009 to 2.576 mug/m3 (mean of 1.006 mug/m3).	glyphosate	4-14	thrombospondin 1	Homo sapiens	31-34
31066122-7	2019	In addition, the expression of synaptophysin was up-regulated by glyphosate in the dorsal and ventral dentate gyrus and CA3 regions of the hippocampus, and down-regulated in the cingulate gyrus.	glyphosate	65-75	synaptophysin	Rattus norvegicus	31-44
31395095-6	2019	Crucially, filtering of data to focus analysis on peptides potentially bearing glycine for glyphosate replacement revealed that the TMT reporter intensity pattern of all candidates showed conclusively that they are all false discoveries, with none displaying the expected TMT pattern for such a substitution.	glyphosate	91-101	tryptase gamma 1	Homo sapiens	132-135
31029961-4	2019	Through abcb4, abcc1, abcc2 and abcc4 gene expression, ABCB and ABCC2 protein expression and ABC pump activity in ZF-L cells exposed to glyphosate and Roundup .	glyphosate	136-146	ATP-binding cassette, sub-family B (MDR/TAP), member 4	Danio rerio	8-13
31029961-4	2019	Through abcb4, abcc1, abcc2 and abcc4 gene expression, ABCB and ABCC2 protein expression and ABC pump activity in ZF-L cells exposed to glyphosate and Roundup .	glyphosate	136-146	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	Danio rerio	15-20
31029961-4	2019	Through abcb4, abcc1, abcc2 and abcc4 gene expression, ABCB and ABCC2 protein expression and ABC pump activity in ZF-L cells exposed to glyphosate and Roundup .	glyphosate	136-146	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Danio rerio	22-27
31029961-4	2019	Through abcb4, abcc1, abcc2 and abcc4 gene expression, ABCB and ABCC2 protein expression and ABC pump activity in ZF-L cells exposed to glyphosate and Roundup .	glyphosate	136-146	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	Danio rerio	32-37
31029961-4	2019	Through abcb4, abcc1, abcc2 and abcc4 gene expression, ABCB and ABCC2 protein expression and ABC pump activity in ZF-L cells exposed to glyphosate and Roundup .	glyphosate	136-146	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Danio rerio	64-69
30981909-6	2019	Through molecular docking we have shown for the first time that the interactions of glucokinase and hexokinases 1 and 2 with glyphosate showed significant interactions in the active sites, corroborating the biochemical results of hexokinase activity in zebrafish exposed to the chemical.	glyphosate	125-135	glucokinase (hexokinase 4)	Danio rerio	84-119
30981909-7	2019	From the results of molecular docking interactions carried out on the Zfishglucok, ZfishHK1 and ZfishHK2 models with the glyphosate linker, it can be concluded that there are significant interactions between glyphosate and active sites of glucokinase and hexokinase 1 and 2 proteins.	glyphosate	121-131	glucokinase (hexokinase 4)	Danio rerio	239-250
30981909-7	2019	From the results of molecular docking interactions carried out on the Zfishglucok, ZfishHK1 and ZfishHK2 models with the glyphosate linker, it can be concluded that there are significant interactions between glyphosate and active sites of glucokinase and hexokinase 1 and 2 proteins.	glyphosate	121-131	hexokinase 1	Danio rerio	255-273
30981909-7	2019	From the results of molecular docking interactions carried out on the Zfishglucok, ZfishHK1 and ZfishHK2 models with the glyphosate linker, it can be concluded that there are significant interactions between glyphosate and active sites of glucokinase and hexokinase 1 and 2 proteins.	glyphosate	208-218	glucokinase (hexokinase 4)	Danio rerio	239-250
30981909-7	2019	From the results of molecular docking interactions carried out on the Zfishglucok, ZfishHK1 and ZfishHK2 models with the glyphosate linker, it can be concluded that there are significant interactions between glyphosate and active sites of glucokinase and hexokinase 1 and 2 proteins.	glyphosate	208-218	hexokinase 1	Danio rerio	255-273
31370256-10	2019	Glyphosate"s synergistic health effects in combination with exposure to other pollutants, in particular paraquat, and physical labor in the ubiquitous high temperatures of lowland tropical regions, could result in renal damage consistent with CKDu in Sri Lanka.	glyphosate	0-10	sorcin	Homo sapiens	251-254
31277689-7	2019	RESULTS: Vk*MYC mice under glyphosate exposure developed progressive hematological abnormalities and plasma cell neoplasms such as splenomegaly, anemia, and high serum IgG.	glyphosate	27-37	immunoglobulin heavy chain (V7183 family)	Mus musculus	168-171
31277689-9	2019	Glyphosate-treated wild-type mice developed benign monoclonal gammopathy with increased serum IgG, anemia, and plasma cell presence in the spleen and bone marrow.	glyphosate	0-10	immunoglobulin heavy chain (V7183 family)	Mus musculus	94-97
31277689-10	2019	Finally, glyphosate upregulated AID in the spleen and bone marrow of both wild-type and Vk*MYC mice.	glyphosate	9-19	activation-induced cytidine deaminase	Mus musculus	32-35
31130932-8	2019	Pathogenic and non-extended-spectrum beta-lactamase (non-ESBL) E. coli isolates each showed significantly higher MIC values compared to commensals and ESBL-producing E. coli in pure glyphosate, but not in the complete formulation.	glyphosate	182-192	EsbL	Escherichia coli	57-61
30907447-5	2019	We found that NMDAR1 expression, as well as intracellular Ca2+ ([Ca2+ ]i ) and reactive oxygen species (ROS) levels, increased after glyphosate treatment.	glyphosate	133-143	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	14-20
30907447-10	2019	These results strongly suggest that activation of the NMDAR1 pathway, together with its downstream [Ca2+ ]i and oxidative stress, is involved in glyphosate-induced renal proximal tubule epithelium apoptosis.	glyphosate	145-155	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	54-60
31010672-8	2019	Selective downregulation of Cacana1C (L-type calcium channel) and ryr2a (Ryanodine receptor) genes along with selective upregulation of hspb11 (heat shock protein) gene was observed upon exposure to glyphosate indicating alterations in the calcium signaling.	glyphosate	199-209	ryanodine receptor 2a (cardiac)	Danio rerio	66-71
31010672-8	2019	Selective downregulation of Cacana1C (L-type calcium channel) and ryr2a (Ryanodine receptor) genes along with selective upregulation of hspb11 (heat shock protein) gene was observed upon exposure to glyphosate indicating alterations in the calcium signaling.	glyphosate	199-209	heat shock protein, alpha-crystallin-related, b9-like	Danio rerio	136-142
30981933-5	2019	Glyphosate displayed variable levels (4-3,000 ng L-1), with higher concentrations in south tributaries (e.g., Nicolet and Yamaska).	glyphosate	0-10	immunoglobulin kappa variable 1-16	Homo sapiens	49-52
30875550-11	2019	In the testes, expression of Fshr and Aralpha was significantly reduced in medaka exposed to 0.5 mg/L Roundup and glyphosate, while the expression of Dmrt1 and Dnmt1 was reduced in medaka exposed to 0.5 mg/L glyphosate.	glyphosate	114-124	follicle stimulating hormone receptor	Oryzias latipes	29-33
30875550-11	2019	In the testes, expression of Fshr and Aralpha was significantly reduced in medaka exposed to 0.5 mg/L Roundup and glyphosate, while the expression of Dmrt1 and Dnmt1 was reduced in medaka exposed to 0.5 mg/L glyphosate.	glyphosate	114-124	androgen receptor beta	Oryzias latipes	38-45
30875550-11	2019	In the testes, expression of Fshr and Aralpha was significantly reduced in medaka exposed to 0.5 mg/L Roundup and glyphosate, while the expression of Dmrt1 and Dnmt1 was reduced in medaka exposed to 0.5 mg/L glyphosate.	glyphosate	208-218	follicle stimulating hormone receptor	Oryzias latipes	29-33
30875550-11	2019	In the testes, expression of Fshr and Aralpha was significantly reduced in medaka exposed to 0.5 mg/L Roundup and glyphosate, while the expression of Dmrt1 and Dnmt1 was reduced in medaka exposed to 0.5 mg/L glyphosate.	glyphosate	208-218	androgen receptor beta	Oryzias latipes	38-45
30875550-11	2019	In the testes, expression of Fshr and Aralpha was significantly reduced in medaka exposed to 0.5 mg/L Roundup and glyphosate, while the expression of Dmrt1 and Dnmt1 was reduced in medaka exposed to 0.5 mg/L glyphosate.	glyphosate	208-218	doublesex- and mab-3-related transcription factor 1Y	Oryzias latipes	150-155
30605748-4	2019	In this study, we investigated the effect of acute exposure to glyphosate (GPH) on the blood-brain barrier in vitro based on induced pluripotent stem cells (iPSCs) and compared to two chemical analogs: aminomethylphosphonic acid (AMPA) and glycine (GLY), for concentrations ranging from 0.1 muM to 1000 muM.	glyphosate	63-73	latexin	Homo sapiens	291-294
31275269-2	2019	In this study, the maize root-associated bacterial communities of 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) transgenic glyphosate-tolerant (GT) maize line CC-2 (CC2) and its recipient variety Zhengdan958 (Z958) were compared at the tasseling and flowering stages by high-throughput sequencing of V3-V4 hypervariable regions of 16S rRNA gene (16S rDNA) amplicons via Illumina MiSeq.	glyphosate	129-139	cystatin 2	Zea mays	171-174
30785197-12	2019	Moreover, the undifferentiated spermatogonia numbers were decreased by 60% in 5 mg/kg/day glyphosate group, which could be due to the alterations in the expression of genes involved in germ cell differentiation such as Sall4 and Nano3 and apoptosis as Bax and Bcl2.	glyphosate	90-100	spalt like transcription factor 4	Mus musculus	219-224
30785197-12	2019	Moreover, the undifferentiated spermatogonia numbers were decreased by 60% in 5 mg/kg/day glyphosate group, which could be due to the alterations in the expression of genes involved in germ cell differentiation such as Sall4 and Nano3 and apoptosis as Bax and Bcl2.	glyphosate	90-100	BCL2-associated X protein	Mus musculus	252-255
30785197-12	2019	Moreover, the undifferentiated spermatogonia numbers were decreased by 60% in 5 mg/kg/day glyphosate group, which could be due to the alterations in the expression of genes involved in germ cell differentiation such as Sall4 and Nano3 and apoptosis as Bax and Bcl2.	glyphosate	90-100	B cell leukemia/lymphoma 2	Mus musculus	260-264
29187069-5	2019	The equilibrium time for the adsorption of glyphosate when using GO-alpha-gamma-Fe2O3 was 2 hours and the maximum removal was 92% at 15 C, with a maximum adsorption capacity of 46.8 mg g-1.	glyphosate	43-53	tripartite motif containing 47	Homo sapiens	65-73
29187069-7	2019	The thermodynamic parameters showed that the adsorption of glyphosate on GO-alpha-gamma-Fe2O3 was spontaneous, exothermic and thermodynamically favorable at temperature of 15-45 C. Thus the adsorbent material GO-alpha-gamma-Fe2O3 proposed in this study is considered a good candidate to be used in the removal of glyphosate from aqueous solutions, presenting high adsorption capacity, low cost and magnetic properties that facilitate the separation of the adsorbent material.	glyphosate	59-69	tripartite motif containing 47	Homo sapiens	73-81
29187069-7	2019	The thermodynamic parameters showed that the adsorption of glyphosate on GO-alpha-gamma-Fe2O3 was spontaneous, exothermic and thermodynamically favorable at temperature of 15-45 C. Thus the adsorbent material GO-alpha-gamma-Fe2O3 proposed in this study is considered a good candidate to be used in the removal of glyphosate from aqueous solutions, presenting high adsorption capacity, low cost and magnetic properties that facilitate the separation of the adsorbent material.	glyphosate	59-69	tripartite motif containing 47	Homo sapiens	209-217
29187069-7	2019	The thermodynamic parameters showed that the adsorption of glyphosate on GO-alpha-gamma-Fe2O3 was spontaneous, exothermic and thermodynamically favorable at temperature of 15-45 C. Thus the adsorbent material GO-alpha-gamma-Fe2O3 proposed in this study is considered a good candidate to be used in the removal of glyphosate from aqueous solutions, presenting high adsorption capacity, low cost and magnetic properties that facilitate the separation of the adsorbent material.	glyphosate	313-323	tripartite motif containing 47	Homo sapiens	73-81
30685666-7	2019	The evaluation of the antioxidant system showed that GLY interfered with several antioxidant metabolites (proline, ascorbate and glutathione) and enzyme activities (superoxide dismutase - SOD; catalase - CAT; ascorbate peroxidase - APX), generally inducing a positive response of the defense mechanisms.	glyphosate	53-56	peroxidase	Solanum lycopersicum	219-229
30685666-7	2019	The evaluation of the antioxidant system showed that GLY interfered with several antioxidant metabolites (proline, ascorbate and glutathione) and enzyme activities (superoxide dismutase - SOD; catalase - CAT; ascorbate peroxidase - APX), generally inducing a positive response of the defense mechanisms.	glyphosate	53-56	cytosolic ascorbate peroxidase 2	Solanum lycopersicum	232-235
30605748-4	2019	In this study, we investigated the effect of acute exposure to glyphosate (GPH) on the blood-brain barrier in vitro based on induced pluripotent stem cells (iPSCs) and compared to two chemical analogs: aminomethylphosphonic acid (AMPA) and glycine (GLY), for concentrations ranging from 0.1 muM to 1000 muM.	glyphosate	63-73	latexin	Homo sapiens	303-306
30605748-5	2019	GPH treatment (1 and 10 muM) for 24 h showed an increase BBB permeability to fluorescein, with similar outcomes for AMPA.	glyphosate	0-3	latexin	Homo sapiens	24-27
30605748-7	2019	Although no detrimental effects were observed on neuron differentiation at high doses, we noted changes in neuronal cell metabolic activity and glucose uptake in brain microvascular endothelial cells (BMECs) following treatment with 100 muM GPH or AMPA.	glyphosate	241-244	latexin	Homo sapiens	237-240
29691751-2	2018	Consequently, a significant amount of PMG, its metabolites (sarcosine, SAR, and aminomethylphosphonic acid, AMPA) and the degradation product, methylphosphonic acid (MPA), reaches the soil, which acts as final sink.	glyphosate	38-41	sarcosine dehydrogenase	Homo sapiens	71-74
30821249-0	2019	Glyphosate disrupts redox status and up-regulates metallothionein I and II genes expression in the liver of adult rats.	glyphosate	0-10	metallothionein 1	Rattus norvegicus	50-67
30821249-6	2019	Glyphosate-induced hepatic oxidative stress was evidenced by the increased levels of malondialdehyde, hydrogen peroxide, advanced oxidation protein products and protein carbonyls with a significant decrease in enzymatic (superoxide dismutase, catalase, glutathione peroxidase) and non-enzymatic (non-protein thiols, glutathione, vitamin C) antioxidants.	glyphosate	0-10	catalase	Rattus norvegicus	243-251
30821249-8	2019	Moreover, glyphosate induced DNA damage, up-regulated metallothionein (MT I and MT II) genes expression and provoked histopathological changes in rats" liver.	glyphosate	10-20	metallothionein 1	Rattus norvegicus	71-85
30266436-8	2019	Fungicide iprodione, possibly acting as a progestin mimic, promoted hCG-induced GVBD at the lowest concentration of 20 muM, while the weed killer glyphosate inhibited hCG-induced GVBD starting at the 50 muM concentration.	glyphosate	146-156	hypertrichosis 2 (generalised, congenital)	Homo sapiens	167-170
30640360-1	2019	The purpose of this study was to determine the effect of PO on the sorption and transport of glyphosate [-(phosphonomethyl) glycine, GPS] in soils.	glyphosate	93-103	neurobeachin like 2	Homo sapiens	133-136
30411421-6	2019	GLP exposure also led to a significant decline in the antioxidant enzymes" activity, namely, SOD, catalase, and GST along with enhanced lipid peroxidation and reduced FRAP activity in a dose- and time-dependent manner.	glyphosate	0-3	superoxide dismutase 1	Homo sapiens	93-96
30411421-6	2019	GLP exposure also led to a significant decline in the antioxidant enzymes" activity, namely, SOD, catalase, and GST along with enhanced lipid peroxidation and reduced FRAP activity in a dose- and time-dependent manner.	glyphosate	0-3	catalase	Homo sapiens	98-106
30411421-6	2019	GLP exposure also led to a significant decline in the antioxidant enzymes" activity, namely, SOD, catalase, and GST along with enhanced lipid peroxidation and reduced FRAP activity in a dose- and time-dependent manner.	glyphosate	0-3	mechanistic target of rapamycin kinase	Homo sapiens	167-171
30247042-1	2018	A molecular theory has been applied to study the equilibrium conditions of glyphosate and aminomethylphosphonic acid (AMPA) adsorption from aqueous solutions to hydrogel films of cross-linked polyallylamine (PAH).	glyphosate	75-85	phenylalanine hydroxylase	Homo sapiens	208-211
30247042-9	2018	Thus, PAH hydrogel films can be considered as functional materials that combine glyphosate sequestration and in situ degradation.	glyphosate	80-90	phenylalanine hydroxylase	Homo sapiens	6-9
30682438-0	2019	Learning and memory impairments associated to acetylcholinesterase inhibition and oxidative stress following glyphosate based-herbicide exposure in mice.	glyphosate	109-119	acetylcholinesterase	Mus musculus	46-66
30425098-0	2019	Desensitizing plant EPSP synthase to glyphosate: Optimized global sequence context accommodates a glycine-to-alanine change in the active site.	glyphosate	37-47	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	20-33
30425098-1	2019	5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) catalyzes the transfer of a carboxyvinyl group from phosphoenolpyruvate (PEP) to shikimate-3-phosphate and in plants is the target of the herbicide glyphosate.	glyphosate	200-210	phosphoenolpyruvate carboxylase 2	Zea mays	125-128
30425098-6	2019	A large portion of the reduction in Km was conferred by two down-sizing substitutions (L97C and V332A) within 8 A of glyphosate, which together reduced Km for PEP to 43 mum Although the original optimization was conducted with maize EPSPS, contextually homologous substitutions conferred similar properties to the EPSPSs of other crops.	glyphosate	117-127	phosphoenolpyruvate carboxylase 2	Zea mays	159-162
30425098-7	2019	We also discovered a variant having the known glyphosate-desensitizing substitution P106L plus three additional ones that reduced the Km for PEP from 47 mum, observed with P106L alone, to 10.3 mum The improvements obtained with both Ala101 and Leu106 have implications regarding glyphosate-tolerant crops and weeds.	glyphosate	46-56	phosphoenolpyruvate carboxylase 2	Zea mays	141-144
30425098-7	2019	We also discovered a variant having the known glyphosate-desensitizing substitution P106L plus three additional ones that reduced the Km for PEP from 47 mum, observed with P106L alone, to 10.3 mum The improvements obtained with both Ala101 and Leu106 have implications regarding glyphosate-tolerant crops and weeds.	glyphosate	279-289	phosphoenolpyruvate carboxylase 2	Zea mays	141-144
30535527-5	2019	The limit of detection for glyphosate and AMPA was 0.25 mug L-1 and the limit of quantification was 0.5 mug L-1with a 20-muL injection.	glyphosate	27-37	immunoglobulin kappa variable 1-16	Homo sapiens	60-63
30535527-8	2019	However, glyphosate was detected above the limit of quantification in 33% of the wetland samples (n = 12), with concentrations ranging from 1.95 to 2.96 mug L-1.	glyphosate	9-19	immunoglobulin kappa variable 1-16	Homo sapiens	157-160
29948720-7	2018	The average concentrations (all samples) were 0.17, 0.18, and 0.10 mug L-1 for glyphosate, AMPA, and glufosinate ammonium, respectively.	glyphosate	79-89	immunoglobulin kappa variable 1-16	Homo sapiens	71-74
29890199-0	2018	Glyphosate induces growth of estrogen receptor alpha positive cholangiocarcinoma cells via non-genomic estrogen receptor/ERK1/2 signaling pathway.	glyphosate	0-10	estrogen receptor 1	Homo sapiens	29-52
29890199-0	2018	Glyphosate induces growth of estrogen receptor alpha positive cholangiocarcinoma cells via non-genomic estrogen receptor/ERK1/2 signaling pathway.	glyphosate	0-10	estrogen receptor 1	Homo sapiens	29-46
29890199-0	2018	Glyphosate induces growth of estrogen receptor alpha positive cholangiocarcinoma cells via non-genomic estrogen receptor/ERK1/2 signaling pathway.	glyphosate	0-10	mitogen-activated protein kinase 3	Homo sapiens	121-127
29890199-11	2018	These effects of glyphosate and E2 were abolished by the ER antagonist, 4-hydroxytamoxifen and U0126, a MEK inhibitor.	glyphosate	17-27	mitogen-activated protein kinase kinase 7	Homo sapiens	104-107
29890199-12	2018	The data from this study indicate that glyphosate can induce cell growth in ERalpha positive CCA cells through non-genomic estrogen receptor/ERK1/2 signaling pathway.	glyphosate	39-49	estrogen receptor 1	Homo sapiens	76-83
29890199-12	2018	The data from this study indicate that glyphosate can induce cell growth in ERalpha positive CCA cells through non-genomic estrogen receptor/ERK1/2 signaling pathway.	glyphosate	39-49	estrogen receptor 1	Homo sapiens	123-140
29890199-12	2018	The data from this study indicate that glyphosate can induce cell growth in ERalpha positive CCA cells through non-genomic estrogen receptor/ERK1/2 signaling pathway.	glyphosate	39-49	mitogen-activated protein kinase 3	Homo sapiens	141-147
28111921-3	2018	RESULTS: Glyphosate (1 mg L-1 ) sorption on biochars increased with pyrolysis temperature and was highest on 900  C biochars; however, total sorption was low on a mass basis (<0.1 mg g-1 ).	glyphosate	9-19	immunoglobulin kappa variable 1-16	Homo sapiens	26-29
30814880-1	2018	Glyphosate is a widely used herbicide that inhibits the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS)-encoding aroA gene in the shikimate pathway.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	56-99
29467848-12	2018	Nr4a2 and Wnt7b were downregulated, while Dkk1, Dixdc1, Runx1, Shh, Lef-1 and Axin2 were upregulated in the PFC of mice offspring following glyphosate exposure during pregnancy and lactation.	glyphosate	140-150	runt related transcription factor 1	Mus musculus	56-61
29284371-3	2018	The results suggest that pasta is a very important foodstuff for dietary glyphosate residue intake in Switzerland.	glyphosate	73-83	solute carrier family 45 member 1	Homo sapiens	25-30
29649228-0	2018	An intragenic approach to confer glyphosate resistance in chile (Capsicum annuum) by introducing an in vitro mutagenized chile EPSPS gene encoding for a glyphosate resistant EPSPS protein.	glyphosate	33-43	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	127-132
29649228-0	2018	An intragenic approach to confer glyphosate resistance in chile (Capsicum annuum) by introducing an in vitro mutagenized chile EPSPS gene encoding for a glyphosate resistant EPSPS protein.	glyphosate	33-43	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	174-179
29649228-0	2018	An intragenic approach to confer glyphosate resistance in chile (Capsicum annuum) by introducing an in vitro mutagenized chile EPSPS gene encoding for a glyphosate resistant EPSPS protein.	glyphosate	153-163	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	127-132
29649228-0	2018	An intragenic approach to confer glyphosate resistance in chile (Capsicum annuum) by introducing an in vitro mutagenized chile EPSPS gene encoding for a glyphosate resistant EPSPS protein.	glyphosate	153-163	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	174-179
29649228-3	2018	Glyphosate inactivates the enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS), a key enzyme in the synthesis of aromatic amino acids.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	79-84
29649228-4	2018	A transgenic approach towards making glyphosate resistant plants, entails introducing copies of a gene encoding for glyphosate-resistant EPSPS enzyme into the plant.	glyphosate	37-47	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	137-142
29649228-4	2018	A transgenic approach towards making glyphosate resistant plants, entails introducing copies of a gene encoding for glyphosate-resistant EPSPS enzyme into the plant.	glyphosate	116-126	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	137-142
29649228-7	2018	An EPSPS gene was isolated from chile and mutagenized to introduce substitutions that are known to make the encoded enzyme resistant to glyphosate.	glyphosate	136-146	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	3-8
29649228-14	2018	However, we need a stronger chile promoter and a mutated chile gene that encodes for a more glyphosate resistant EPSPS protein.	glyphosate	92-102	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Capsicum annuum	113-118
29375605-0	2017	Overlapping Residual Herbicides for Control of Photosystem (PS) II- and 4-Hydroxyphenylpyruvate Dioxygenase (HPPD)-Inhibitor-Resistant Palmer amaranth (Amaranthus palmeri S. Watson) in Glyphosate-Resistant Maize.	glyphosate	185-195	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	72-107
29100121-6	2018	The highest glyphosate concentrations (500 and 1000 mug l-1) affected the shikimate content, the lipid peroxidation and the activity of antioxidant enzymes (superoxide dismutase, catalase and ascorbate peroxidase).	glyphosate	12-22	catalase	Homo sapiens	179-187
29375605-0	2017	Overlapping Residual Herbicides for Control of Photosystem (PS) II- and 4-Hydroxyphenylpyruvate Dioxygenase (HPPD)-Inhibitor-Resistant Palmer amaranth (Amaranthus palmeri S. Watson) in Glyphosate-Resistant Maize.	glyphosate	185-195	4-hydroxyphenylpyruvate dioxygenase 1	Zea mays	109-113
29018930-4	2017	Under the optimal experimental conditions, the DPV peak currents of hexacyanoferrate/hexacyanoferrite changed linearly with Gly concentration in the range from 5 to 800 ng mL-1, with a detection limit of 0.27 ng mL-1 (S/N = 3).	glyphosate	124-127	L1 cell adhesion molecule	Mus musculus	172-176
29883246-0	2018	Glyphosate and AMPA of agricultural soil, surface water, groundwater and sediments in areas prevalent with chronic kidney disease of unknown etiology, Sri Lanka.	glyphosate	0-10	sorcin	Homo sapiens	151-154
29883246-1	2018	Glyphosate, which is commercially available as Roundup , was the widely used herbicide in Sri Lanka until 2015 and is suspected to be one of the causal factors for Chronic Kidney Disease of unknown etiology (CKDu).	glyphosate	0-10	sorcin	Homo sapiens	90-93
29680783-4	2018	In this study, we show that, although both ILA and GCN2 genes are necessary to mediate eIF2alpha phosphorylation upon treatments with the aromatic amino acid biosynthesis inhibitor glyphosate, their mutants develop distinct root and chloroplast phenotypes.	glyphosate	181-191	ILITYHIA	Arabidopsis thaliana	43-46
29680783-4	2018	In this study, we show that, although both ILA and GCN2 genes are necessary to mediate eIF2alpha phosphorylation upon treatments with the aromatic amino acid biosynthesis inhibitor glyphosate, their mutants develop distinct root and chloroplast phenotypes.	glyphosate	181-191	protein kinase family protein	Arabidopsis thaliana	51-55
29680783-4	2018	In this study, we show that, although both ILA and GCN2 genes are necessary to mediate eIF2alpha phosphorylation upon treatments with the aromatic amino acid biosynthesis inhibitor glyphosate, their mutants develop distinct root and chloroplast phenotypes.	glyphosate	181-191	eukaryotic translation initiation factor 2 alpha subunit	Arabidopsis thaliana	87-96
29018930-4	2017	Under the optimal experimental conditions, the DPV peak currents of hexacyanoferrate/hexacyanoferrite changed linearly with Gly concentration in the range from 5 to 800 ng mL-1, with a detection limit of 0.27 ng mL-1 (S/N = 3).	glyphosate	124-127	L1 cell adhesion molecule	Mus musculus	212-216
28112035-7	2017	Glyphosate concentration (C0 = 16.9 mg L-1) decreased up to 0.6 mg L-1 when the optimal conditions were imposed (current intensity of 4.77 A and treatment time of 173 min).	glyphosate	0-10	L1 cell adhesion molecule	Homo sapiens	39-42
28112035-7	2017	Glyphosate concentration (C0 = 16.9 mg L-1) decreased up to 0.6 mg L-1 when the optimal conditions were imposed (current intensity of 4.77 A and treatment time of 173 min).	glyphosate	0-10	L1 cell adhesion molecule	Homo sapiens	67-70
28407950-2	2017	Glyphosate was converted into dithiocarbamic acid with CS2, followed by copper in the presence of ammonia to promote complex formation.	glyphosate	0-10	chorionic somatomammotropin hormone 2	Homo sapiens	55-58
29155836-0	2017	Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.	glyphosate	100-110	Dip5p	Saccharomyces cerevisiae S288C	21-25
29155836-0	2017	Genetic variation in Dip5, an amino acid permease, and Pdr5, a multiple drug transporter, regulates glyphosate resistance in S. cerevisiae.	glyphosate	100-110	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	55-59
29155836-8	2017	Sequence comparison between the target proteins, i.e., the plant EPSPS and the yeast orthologous protein Aro1, predicted that yeast would be resistant to glyphosate.	glyphosate	154-164	pentafunctional protein ARO1p	Saccharomyces cerevisiae S288C	105-109
29110107-3	2017	Average percent recoveries of glyphosate and AMPA from distilled, tap, and ground water ranged from 87.5 to 94.9, 87.3 to 93.7, and 80.6 to 92.0, respectively, with relative standard deviation less than 10%.	glyphosate	30-40	nuclear RNA export factor 1	Homo sapiens	66-69
29110107-4	2017	The limit of detection and limit of quantification of glyphosate and AMPA from different water matrices ranged from 0.001 to 0.03 mug mL-1 and 0.003 to 0.01 mug mL-1, respectively.	glyphosate	54-64	L1 cell adhesion molecule	Mus musculus	134-138
29110107-4	2017	The limit of detection and limit of quantification of glyphosate and AMPA from different water matrices ranged from 0.001 to 0.03 mug mL-1 and 0.003 to 0.01 mug mL-1, respectively.	glyphosate	54-64	L1 cell adhesion molecule	Mus musculus	161-165
28888161-7	2017	In this study, we provide new evidence on the participation of G6PDH and 6PGDH in the response to oxidative stress induced by glyphosate in Arabidopsis, in which peroxisomal enzymes, such as catalase and glycolate oxidase, are positively affected.	glyphosate	126-136	catalase 2	Arabidopsis thaliana	191-199
28888161-8	2017	We suggest that the NADPH provided by the oxidative phase of the pentose phosphate pathway (OxPPP) should serve to maintain glutathione reductase (GR) activity, thus preserving and regenerating the intracellular GSH pool under glyphosate-induced stress.	glyphosate	227-237	glutathione reductase	Arabidopsis thaliana	124-145
28888161-8	2017	We suggest that the NADPH provided by the oxidative phase of the pentose phosphate pathway (OxPPP) should serve to maintain glutathione reductase (GR) activity, thus preserving and regenerating the intracellular GSH pool under glyphosate-induced stress.	glyphosate	227-237	glutathione reductase	Arabidopsis thaliana	147-149
28577236-1	2017	KEY MESSAGE: Triticum durum Glutathione S-transferase Z1 is specifically responsive to glyphosate.	glyphosate	87-97	glutathione S-transferase	Nicotiana tabacum	28-53
28711546-0	2017	Evaluation of estrogen receptor alpha activation by glyphosate-based herbicide constituents.	glyphosate	52-62	estrogen receptor 1	Homo sapiens	14-37
28711546-7	2017	Calculation of glyphosate binding energy to ERalpha predicts a weak and unstable interaction (-4.10 kcal mol-1) compared to estradiol (-25.79 kcal mol-1), which suggests that activation of this receptor by glyphosate is via a ligand-independent mechanism.	glyphosate	15-25	estrogen receptor 1	Homo sapiens	44-51
28711546-7	2017	Calculation of glyphosate binding energy to ERalpha predicts a weak and unstable interaction (-4.10 kcal mol-1) compared to estradiol (-25.79 kcal mol-1), which suggests that activation of this receptor by glyphosate is via a ligand-independent mechanism.	glyphosate	206-216	estrogen receptor 1	Homo sapiens	44-51
28711546-9	2017	Our study reveals that glyphosate, but not other components present in GBHs, can activate ERalpha in vitro, albeit at relatively high concentrations.	glyphosate	23-33	estrogen receptor 1	Homo sapiens	90-97
28351773-6	2017	Glyphosate at 0.25 mM and 0.5 mM increased p53 promoter methylation, while it did not induce statistically significant changes in methylation of p16 promoter.	glyphosate	0-10	tumor protein p53	Homo sapiens	43-46
28448908-5	2017	The expression of ntl (no tail) shortened and krox20 (also known as Egr2b, early growth response 2b) changed as the glyphosate concentration increased, but there was no change in the expression of shh (sonic hedgehog).	glyphosate	116-126	early growth response 2b	Danio rerio	46-52
28448908-5	2017	The expression of ntl (no tail) shortened and krox20 (also known as Egr2b, early growth response 2b) changed as the glyphosate concentration increased, but there was no change in the expression of shh (sonic hedgehog).	glyphosate	116-126	early growth response 2b	Danio rerio	68-73
28301275-0	2017	Serum S100 protein could predict altered consciousness in glyphosate or glufosinate poisoning patients.	glyphosate	58-68	S100 calcium binding protein B	Homo sapiens	6-10
28301275-2	2017	The aim of this study was to assess the possible role of serum S100B protein as a biochemical marker of CNS complications associated with glyphosate or glufosinate poisoning.	glyphosate	138-148	S100 calcium binding protein B	Homo sapiens	63-68
28301275-7	2017	Univariate analysis of measured patient raw parameters using a ROC curve showed that S100B was a significant predictor of neurologic features in glyphosate and glufosinate poisoning.	glyphosate	145-155	S100 calcium binding protein B	Homo sapiens	85-90
28301275-9	2017	When S100B was set at 0.0965, its sensitivity and specificity for predicting neurologic features in glyphosate and glufosinate poisoning were 92% and 82%, respectively.	glyphosate	100-110	S100 calcium binding protein B	Homo sapiens	5-10
28301275-10	2017	CONCLUSIONS: In our pilot study, S100B was a significant predictor of neurologic complications in patients with glyphosate and glufosinate poisoning.	glyphosate	112-122	S100 calcium binding protein B	Homo sapiens	33-38
28357792-8	2017	The same concentration factor and analytical method were applied to 100 ng L-1 spiked sea water with recoveries of 96% for GLY and 121% for AMPA.	glyphosate	123-126	immunoglobulin kappa variable 1-16	Homo sapiens	75-78
28552945-4	2017	We observed that, after immediate application (1 day), the highest dose of glyphosate (100FR) negatively affected the alkaline phosphatase (AlP) activity in soils without N fertilization history and decreased the cation exchange capacity (CEC) in N0 compared to CK and FR treatments with N+.	glyphosate	75-85	alkaline phosphatase, placental	Homo sapiens	118-138
28552945-4	2017	We observed that, after immediate application (1 day), the highest dose of glyphosate (100FR) negatively affected the alkaline phosphatase (AlP) activity in soils without N fertilization history and decreased the cation exchange capacity (CEC) in N0 compared to CK and FR treatments with N+.	glyphosate	75-85	alkaline phosphatase, placental	Homo sapiens	140-143
28224177-0	2017	Joint Toxicity of Arsenic, Copper and Glyphosate on Behavior, Reproduction and Heat Shock Protein Response in Caenorhabditis elegans.	glyphosate	38-48	Heat shock protein 110	Caenorhabditis elegans	79-97
28357792-4	2017	This protocol was first applied to mineral water spiked by GLY and AMPA at environmental concentration levels (25-750 ng L-1).	glyphosate	59-62	immunoglobulin kappa variable 1-16	Homo sapiens	121-124
26350405-9	2015	The proline content and peroxidase activity showed that glyphosate could induce proline accumulation and produce reactive oxygen species.	glyphosate	56-66	peroxidase	Arabidopsis thaliana	24-34
28461732-0	2017	Genetically transformed tobacco plants expressing synthetic EPSPS gene confer tolerance against glyphosate herbicide.	glyphosate	96-106	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	60-65
28461732-1	2017	Glyphosate quashes the synthesis of 5-enolpyruvylshikimate-3- phosphate synthase (EPSPS) enzyme which intercedes the functioning of shikimate pathway for the production of aromatic amino acids.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	36-80
28461732-1	2017	Glyphosate quashes the synthesis of 5-enolpyruvylshikimate-3- phosphate synthase (EPSPS) enzyme which intercedes the functioning of shikimate pathway for the production of aromatic amino acids.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	82-87
28461732-4	2017	Intentions behind this study were to design and characterize the synthetic herbicide resistant CP4-EPSPS gene in a model plant system and check the effectiveness of transformed tobacco against application of glyphosate.	glyphosate	208-218	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	99-104
28461732-9	2017	This codon optimized synthetic CP4-EPSPS gene is functionally equivalent to the gene for glyphosate resistance available in the commercial crops and hence we recommend this gene for transformation into commercial crops.	glyphosate	89-99	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	35-40
28185844-5	2017	Several glyphosate concentrations were assessed, ranging from 15 mM to 0.1 muM.	glyphosate	8-18	latexin	Homo sapiens	75-78
27906609-0	2017	Glyphosate Adversely Affects Danio rerio Males: Acetylcholinesterase Modulation and Oxidative Stress.	glyphosate	0-10	acetylcholinesterase	Danio rerio	48-68
27044015-0	2016	Glyphosate Inhibits PPAR Gamma Induction and Differentiation of Preadipocytes and is able to Induce Oxidative Stress.	glyphosate	0-10	peroxisome proliferator activated receptor gamma	Mus musculus	20-30
26688330-0	2016	Neuronal development and axon growth are altered by glyphosate through a WNT non-canonical signaling pathway.	glyphosate	52-62	Wnt family member 5A	Homo sapiens	73-76
26688330-10	2016	Biochemical approaches revealed that glyphosate led to a decrease in Wnt5a level, a key factor for the initial neurite development and maturation, as well as inducing a down-regulation of CaMKII activity.	glyphosate	37-47	Wnt family member 5A	Homo sapiens	69-74
26688330-10	2016	Biochemical approaches revealed that glyphosate led to a decrease in Wnt5a level, a key factor for the initial neurite development and maturation, as well as inducing a down-regulation of CaMKII activity.	glyphosate	37-47	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	188-194
26688330-11	2016	This data suggests that the morphological defects would likely be a consequence of the decrease in both Wnt5a expression and CaMKII activity induced by glyphosate.	glyphosate	152-162	Wnt family member 5A	Homo sapiens	104-109
26688330-11	2016	This data suggests that the morphological defects would likely be a consequence of the decrease in both Wnt5a expression and CaMKII activity induced by glyphosate.	glyphosate	152-162	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	125-131
26767332-5	2015	The Ag2S/Ag2Mo3O10 nanoheterostructure enhances the photocatalytic activity on the degradations of Rhodamine B and glyphosate under visible light.	glyphosate	115-125	angiotensin II receptor type 1	Homo sapiens	4-8
26568409-1	2015	A straightforward analytical method based on derivatization with fluorenylmethyloxycarbonyl chloride and liquid chromatography-mass spectrometry has been developed for the analysis of residues of glyphosate and aminomethylphosphonic acid (AMPA) in a suite of nutritional ingredients derived from soybean, corn, and sugar beet and also in cow"s milk and human breast milk.	glyphosate	196-206	Weaning weight-maternal milk	Bos taurus	344-348
26568409-1	2015	A straightforward analytical method based on derivatization with fluorenylmethyloxycarbonyl chloride and liquid chromatography-mass spectrometry has been developed for the analysis of residues of glyphosate and aminomethylphosphonic acid (AMPA) in a suite of nutritional ingredients derived from soybean, corn, and sugar beet and also in cow"s milk and human breast milk.	glyphosate	196-206	Weaning weight-maternal milk	Bos taurus	366-370
27906609-5	2017	Although glyphosate concentrations did not alter AChE activity, this study demonstrated for the first time that this molecule affects ache expression in male zebrafish D. rerio.	glyphosate	9-19	acetylcholinesterase	Danio rerio	134-138
32231912-1	2016	The Food Safety Commission of Japan (FSCJ) conducted a risk assessment of glyphosate (CAS No.	glyphosate	74-84	BCAR1 scaffold protein, Cas family member	Rattus norvegicus	86-89
27258137-0	2016	The herbicide glyphosate is a weak inhibitor of acetylcholinesterase in rats.	glyphosate	14-24	acetylcholinesterase	Rattus norvegicus	48-68
27258137-1	2016	The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues.	glyphosate	67-77	acetylcholinesterase	Rattus norvegicus	87-107
27258137-1	2016	The current work evaluated the inhibitory potency of the herbicide glyphosate (GLP) on acetylcholinesterase (AChE) activity in male and female rat tissues.	glyphosate	67-77	acetylcholinesterase	Rattus norvegicus	109-113
26701683-8	2016	The uptake was shown to be ATP and Na(+) independent, and glyphosate permeability could be significantly reduced by the inclusion of competitive amino acids or specific LAT1/LAT2 transporter inhibitors.	glyphosate	58-68	solute carrier family 7 member 5	Homo sapiens	169-173
26701683-8	2016	The uptake was shown to be ATP and Na(+) independent, and glyphosate permeability could be significantly reduced by the inclusion of competitive amino acids or specific LAT1/LAT2 transporter inhibitors.	glyphosate	58-68	linker for activation of T cells family member 2	Homo sapiens	174-178
26701683-9	2016	The pattern of inhibition of glyphosate permeability across Caco-2 and nasal mucosal tissues suggests that LAT1/2 play major roles in the transport of this amino-acid-like herbicide.	glyphosate	29-39	solute carrier family 7 member 5	Homo sapiens	107-113
26342388-0	2015	Glyphosate and AMPA in the estuaries of the Baltic Sea method optimization and field study.	glyphosate	0-10	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	51-54
26342388-6	2015	The data obtained in this study clearly depict the transport of glyphosate and AMPA to the Baltic Sea.	glyphosate	64-74	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	98-101
26197584-5	2015	No obvious influence of glyphosate (0-100 mg   L(-1)) on the recovery rates of GA3 was observed, but the presence of glyphosate could cause slight determination precision decrease of GA3.	glyphosate	117-127	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	183-186
26492960-1	2015	BACKGROUND: 5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the sixth and penultimate enzyme in the shikimate biosynthesis pathway, and is the target of the herbicide glyphosate.	glyphosate	174-184	3-phosphoshikimate 1-carboxyvinyltransferase 2	Triticum aestivum	12-55
26492960-1	2015	BACKGROUND: 5-Enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the sixth and penultimate enzyme in the shikimate biosynthesis pathway, and is the target of the herbicide glyphosate.	glyphosate	174-184	3-phosphoshikimate 1-carboxyvinyltransferase 2	Triticum aestivum	57-62
26465136-1	2015	OBJECTIVE: To provide essential information for peptide inhibitor design, the interactions of Eps15 homology domain of Eps15 homology domain-containing protein 1 (EHD1 EH domain) with three peptides containing NPF (asparagine-proline-phenylalanine), DPF (aspartic acid-proline-phenylalanine), and GPF (glycine-proline-phenylalanine) motifs were deciphered at the atomic level.	glyphosate	297-300	epidermal growth factor receptor pathway substrate 15	Homo sapiens	94-99
26465136-1	2015	OBJECTIVE: To provide essential information for peptide inhibitor design, the interactions of Eps15 homology domain of Eps15 homology domain-containing protein 1 (EHD1 EH domain) with three peptides containing NPF (asparagine-proline-phenylalanine), DPF (aspartic acid-proline-phenylalanine), and GPF (glycine-proline-phenylalanine) motifs were deciphered at the atomic level.	glyphosate	297-300	epidermal growth factor receptor pathway substrate 15	Homo sapiens	119-124
26465136-1	2015	OBJECTIVE: To provide essential information for peptide inhibitor design, the interactions of Eps15 homology domain of Eps15 homology domain-containing protein 1 (EHD1 EH domain) with three peptides containing NPF (asparagine-proline-phenylalanine), DPF (aspartic acid-proline-phenylalanine), and GPF (glycine-proline-phenylalanine) motifs were deciphered at the atomic level.	glyphosate	297-300	EH domain containing 1	Homo sapiens	163-167
25455786-7	2015	The levels of gene expression significantly increased in oysters exposed to the highest glyphosate concentration (GST and metallothioneins) or to all concentrations (multi-xenobiotic resistance).	glyphosate	88-98	Glutathione S-transferase	Crassostrea gigas	114-117
25629880-1	2015	Glyphosate (N-(phosphonomethyl)glycine) (Gph) is a herbicide that is broadly used in several countries.	glyphosate	0-10	gephyrin	Homo sapiens	41-44
25629880-1	2015	Glyphosate (N-(phosphonomethyl)glycine) (Gph) is a herbicide that is broadly used in several countries.	glyphosate	12-39	gephyrin	Homo sapiens	41-44
26197584-6	2015	Meanwhile, adding 2 mg   L(-1) GA3 can increase the recovery rate of glyphosate.	glyphosate	69-79	succinyl-CoA:glutarate-CoA transferase	Homo sapiens	31-34
25763302-11	2015	Glyphosate the most widely used pesticide in Sri Lanka contains average of 1.9 mg/kg arsenic.	glyphosate	0-10	sorcin	Homo sapiens	45-48
25587790-3	2015	Glyphosate soluble powder and aqueous solution were applied at 3000 and 5040 g active ingredient/hm2, respectively, in citrus orchard soils, and periodically drawn soil samples were analyzed by high performance liquid chromatography.	glyphosate	0-10	cholinergic receptor muscarinic 2	Homo sapiens	97-100
25079171-12	2014	Moreover, a negative correlation between IgM antibodies against L. corymbifera, L. ramosa, and Rhizopus relative to glyphosate concentration in urine was observed.	glyphosate	116-126	IgM	Bos taurus	41-44
25603772-0	2015	Protein kinase GCN2 mediates responses to glyphosate in Arabidopsis.	glyphosate	42-52	protein kinase family protein	Arabidopsis thaliana	15-19
25603772-3	2015	RESULTS: In this study, we identify the protein kinase GCN2 as a cellular component that fosters the action of glyphosate in the model plant Arabidopsis thaliana.	glyphosate	111-121	protein kinase family protein	Arabidopsis thaliana	55-59
25603772-5	2015	Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate.	glyphosate	178-188	protein kinase family protein	Arabidopsis thaliana	10-14
25603772-5	2015	Moreover, gcn2 adult plants show a lower inhibition of photosynthesis, and both seedlings and adult gcn2 plants accumulate less shikimic acid than wild-type after treatment with glyphosate.	glyphosate	178-188	protein kinase family protein	Arabidopsis thaliana	100-104
25603772-6	2015	CONCLUSIONS: These results points to an unknown GCN2-dependent factor involved in the cascade of events triggered by glyphosate in plants.	glyphosate	117-127	protein kinase family protein	Arabidopsis thaliana	48-52
26582285-0	2015	Bioremediation potential of glyphosate-degrading Pseudomonas spp.	glyphosate	28-38	histocompatibility minor 13	Homo sapiens	61-64
25079171-13	2014	LBP also was significantly decreased in animals with higher concentrations of glyphosate in their urine.	glyphosate	78-88	lipopolysaccharide binding protein	Bos taurus	0-3
25172162-0	2014	Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation.	glyphosate	0-10	interleukin 33	Mus musculus	35-40
25172162-0	2014	Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation.	glyphosate	0-10	thymic stromal lymphopoietin	Mus musculus	42-46
25172162-0	2014	Glyphosate-rich air samples induce IL-33, TSLP and generate IL-13 dependent airway inflammation.	glyphosate	0-10	interleukin 13	Mus musculus	60-65
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	12-22	interleukin 33	Mus musculus	169-174
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	12-22	thymic stromal lymphopoietin	Mus musculus	176-180
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	12-22	interleukin 13	Mus musculus	182-187
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	12-22	interleukin 5	Mus musculus	193-197
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	51-61	interleukin 33	Mus musculus	169-174
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	51-61	thymic stromal lymphopoietin	Mus musculus	176-180
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	51-61	interleukin 13	Mus musculus	182-187
25172162-7	2014	Exposure to glyphosate-rich air samples as well as glyphosate alone to the lungs increased: eosinophil and neutrophil counts, mast cell degranulation, and production of IL-33, TSLP, IL-13, and IL-5.	glyphosate	51-61	interleukin 5	Mus musculus	193-197
25172162-11	2014	Glyphosate-rich farm air samples as well as glyphosate alone were found to induce pulmonary IL-13-dependent inflammation and promote Th2 type cytokines, but not IL-4 for glyphosate alone.	glyphosate	0-10	interleukin 13	Mus musculus	92-97
25172162-11	2014	Glyphosate-rich farm air samples as well as glyphosate alone were found to induce pulmonary IL-13-dependent inflammation and promote Th2 type cytokines, but not IL-4 for glyphosate alone.	glyphosate	0-10	heart and neural crest derivatives expressed 2	Mus musculus	133-136
25172162-11	2014	Glyphosate-rich farm air samples as well as glyphosate alone were found to induce pulmonary IL-13-dependent inflammation and promote Th2 type cytokines, but not IL-4 for glyphosate alone.	glyphosate	0-10	interleukin 4	Mus musculus	161-165
25172162-11	2014	Glyphosate-rich farm air samples as well as glyphosate alone were found to induce pulmonary IL-13-dependent inflammation and promote Th2 type cytokines, but not IL-4 for glyphosate alone.	glyphosate	44-54	interleukin 13	Mus musculus	92-97
25172162-11	2014	Glyphosate-rich farm air samples as well as glyphosate alone were found to induce pulmonary IL-13-dependent inflammation and promote Th2 type cytokines, but not IL-4 for glyphosate alone.	glyphosate	44-54	heart and neural crest derivatives expressed 2	Mus musculus	133-136
24780534-0	2014	The effect of glyphosate, its metabolites and impurities on erythrocyte acetylcholinesterase activity.	glyphosate	14-24	acetylcholinesterase (Cartwright blood group)	Homo sapiens	72-92
24654847-2	2014	A glyphosate-resistant Arabidopsis mutant (gre1) was isolated and genetic analyses indicated that a dysfunctional red (R) and far-red (FR) light receptor, phytochrome B (phyB), caused this phenotype.	glyphosate	2-12	phytochrome B	Arabidopsis thaliana	155-168
24704689-6	2014	The modified sensor observed wide linear ranges (3.98-176.23 ng mL(-1) and 0.54-3.96 ng mL(-1)) of simultaneous analysis with detection limits as low as 0.35 and 0.19 ng mL(-1) (S/N=3) for glyphosate and glufosinate, respectively, in aqueous samples.	glyphosate	189-199	L1 cell adhesion molecule	Mus musculus	64-70
24704689-6	2014	The modified sensor observed wide linear ranges (3.98-176.23 ng mL(-1) and 0.54-3.96 ng mL(-1)) of simultaneous analysis with detection limits as low as 0.35 and 0.19 ng mL(-1) (S/N=3) for glyphosate and glufosinate, respectively, in aqueous samples.	glyphosate	189-199	L1 cell adhesion molecule	Mus musculus	88-94
24704689-6	2014	The modified sensor observed wide linear ranges (3.98-176.23 ng mL(-1) and 0.54-3.96 ng mL(-1)) of simultaneous analysis with detection limits as low as 0.35 and 0.19 ng mL(-1) (S/N=3) for glyphosate and glufosinate, respectively, in aqueous samples.	glyphosate	189-199	L1 cell adhesion molecule	Mus musculus	88-94
24780534-4	2014	That is why, we have investigated the effect of the most commonly used pesticide: glyphosate, its metabolites and impurities on acetylcholinesterase (AChE) activity (in vitro) in human erythrocytes, which is biochemically similar to acetylcholinesterase present in neural synapses.	glyphosate	82-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	128-148
24780534-4	2014	That is why, we have investigated the effect of the most commonly used pesticide: glyphosate, its metabolites and impurities on acetylcholinesterase (AChE) activity (in vitro) in human erythrocytes, which is biochemically similar to acetylcholinesterase present in neural synapses.	glyphosate	82-92	acetylcholinesterase (Cartwright blood group)	Homo sapiens	150-154
24688297-6	2014	In O. niloticus erythrocytes, significant (p < 0.001) genotoxicity was observed at >= 7 muM, whereas in vitro, glyphosphate was genotoxic in human lymphocytes and Tradescantia hairs at >= 0.7 muM.	glyphosate	117-129	latexin	Homo sapiens	201-204
24688297-7	2014	These results indicate that glyphosate is genotoxic in the cells and organisms studied at concentrations of 0.7-7 muM.	glyphosate	28-38	latexin	Homo sapiens	114-117
24361898-9	2014	Urinary KIM-1 was the best early biomarker of kidney injury in this glyphosate-induced nephrotoxicity model.	glyphosate	68-78	hepatitis A virus cellular receptor 1	Rattus norvegicus	8-13
24324711-6	2013	In this method, an RNAi cassette for suppressing the expression of the nicosulfuron detoxifying enzyme CYP81A9 and an expression cassette for the glyphosate tolerant 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) gene G10 were constructed and transformed into corn via Agrobacterium-mediated transformation.	glyphosate	146-156	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	166-209
24364672-8	2014	Transcript profiling of the gonads revealed 10 mg/L Roundup and glyphosate induced changes in the expression of cyp19a1 and esr1 in the ovary and hsd3b2, cat, and sod1 in the testis.	glyphosate	64-74	cytochrome P450, family 19, subfamily A, polypeptide 1a	Danio rerio	112-119
24364672-8	2014	Transcript profiling of the gonads revealed 10 mg/L Roundup and glyphosate induced changes in the expression of cyp19a1 and esr1 in the ovary and hsd3b2, cat, and sod1 in the testis.	glyphosate	64-74	estrogen receptor 1	Danio rerio	124-128
24364672-8	2014	Transcript profiling of the gonads revealed 10 mg/L Roundup and glyphosate induced changes in the expression of cyp19a1 and esr1 in the ovary and hsd3b2, cat, and sod1 in the testis.	glyphosate	64-74	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2	Danio rerio	146-152
24364672-8	2014	Transcript profiling of the gonads revealed 10 mg/L Roundup and glyphosate induced changes in the expression of cyp19a1 and esr1 in the ovary and hsd3b2, cat, and sod1 in the testis.	glyphosate	64-74	superoxide dismutase 1, soluble	Danio rerio	163-167
24617544-0	2014	Changes in ultrastructure and expression of steroidogenic factor-1 in ovaries of zebrafish Danio rerio exposed to glyphosate.	glyphosate	114-124	nuclear receptor subfamily 5, group A, member 2	Danio rerio	44-66
24617544-9	2014	After glyphosate exposure, immunohistochemistry and immunoblotting revealed greater expression of SF-1 in the oocytes, which suggests a relationship between oocyte growth and SF-1 expression.	glyphosate	6-16	nuclear receptor subfamily 5, group A, member 2	Danio rerio	98-102
23820267-8	2013	Also, exposure to glyphosate-Roundup stimulated the activity of glutathione peroxidase, glutathione reductase, glutathione S-transferase, gamma-glutamyltransferase, catalase, superoxide dismutase, and glucose-6-phosphate dehydrogenase, supporting downregulated GSH levels.	glyphosate	18-28	glutathione-disulfide reductase	Rattus norvegicus	88-109
23820267-8	2013	Also, exposure to glyphosate-Roundup stimulated the activity of glutathione peroxidase, glutathione reductase, glutathione S-transferase, gamma-glutamyltransferase, catalase, superoxide dismutase, and glucose-6-phosphate dehydrogenase, supporting downregulated GSH levels.	glyphosate	18-28	hematopoietic prostaglandin D synthase	Rattus norvegicus	111-136
23820267-8	2013	Also, exposure to glyphosate-Roundup stimulated the activity of glutathione peroxidase, glutathione reductase, glutathione S-transferase, gamma-glutamyltransferase, catalase, superoxide dismutase, and glucose-6-phosphate dehydrogenase, supporting downregulated GSH levels.	glyphosate	18-28	catalase	Rattus norvegicus	165-173
23820267-8	2013	Also, exposure to glyphosate-Roundup stimulated the activity of glutathione peroxidase, glutathione reductase, glutathione S-transferase, gamma-glutamyltransferase, catalase, superoxide dismutase, and glucose-6-phosphate dehydrogenase, supporting downregulated GSH levels.	glyphosate	18-28	glucose-6-phosphate dehydrogenase	Rattus norvegicus	201-234
23831689-9	2013	The levels of increases of GST and AChE were determined to be 111% and 31% for P. ridibundus, 13% and 51% for P. viridis, and 15% and 36% for X. laevis after 3.2mg AI/L glyphosate exposure, respectively.	glyphosate	169-179	hematopoietic prostaglandin D synthase S homeolog	Xenopus laevis	27-30
24273285-0	2013	[Effects of glyphosate on apoptosis and expressions of androgen-binding protein and vimentin mRNA in mouse Sertoli cells].	glyphosate	12-22	secretoglobin, family 1B, member 29	Mus musculus	55-79
24273285-0	2013	[Effects of glyphosate on apoptosis and expressions of androgen-binding protein and vimentin mRNA in mouse Sertoli cells].	glyphosate	12-22	vimentin	Mus musculus	84-92
24273285-1	2013	OBJECTIVE: To investigate the effect of different doses of glyphosate on apoptosis and expressions of androgen-binding protein (ABP) and vimentin mRNA in mouse Sertoli cells.	glyphosate	59-69	secretoglobin, family 1B, member 29	Mus musculus	102-126
24273285-1	2013	OBJECTIVE: To investigate the effect of different doses of glyphosate on apoptosis and expressions of androgen-binding protein (ABP) and vimentin mRNA in mouse Sertoli cells.	glyphosate	59-69	secretoglobin, family 1B, member 29	Mus musculus	128-131
24273285-1	2013	OBJECTIVE: To investigate the effect of different doses of glyphosate on apoptosis and expressions of androgen-binding protein (ABP) and vimentin mRNA in mouse Sertoli cells.	glyphosate	59-69	vimentin	Mus musculus	137-145
23756170-6	2013	Furthermore, glyphosate also altered both ERalpha and beta expression.	glyphosate	13-23	estrogen receptor 1	Homo sapiens	42-49
24073338-6	2013	Additionally, glyphosate also triggers S100A6/S100A9 expression and decreases IP3R1 and SOD 1 expressions in HaCaT cells.	glyphosate	14-24	S100 calcium binding protein A6	Homo sapiens	39-45
24073338-6	2013	Additionally, glyphosate also triggers S100A6/S100A9 expression and decreases IP3R1 and SOD 1 expressions in HaCaT cells.	glyphosate	14-24	S100 calcium binding protein A9	Homo sapiens	46-52
24073338-6	2013	Additionally, glyphosate also triggers S100A6/S100A9 expression and decreases IP3R1 and SOD 1 expressions in HaCaT cells.	glyphosate	14-24	inositol 1,4,5-trisphosphate receptor type 1	Homo sapiens	78-83
24073338-6	2013	Additionally, glyphosate also triggers S100A6/S100A9 expression and decreases IP3R1 and SOD 1 expressions in HaCaT cells.	glyphosate	14-24	superoxide dismutase 1	Homo sapiens	88-93
23535362-3	2013	Our objective was to precisely assess changes in alpha-syn levels in human neuroblastoma (SH-SY5Y) and melanoma (SK-MEL-2) cell lines following acute exposure to pesticides (rotenone, paraquat, maneb, and glyphosate) using Western blot and flow cytometry.	glyphosate	205-215	synuclein alpha	Homo sapiens	49-58
23443944-0	2013	Acetylcholinesterase in honey bees (Apis mellifera) exposed to neonicotinoids, atrazine and glyphosate: laboratory and field experiments.	glyphosate	92-102	acetylcholinesterase	Apis mellifera	0-20
23675691-3	2013	This oligopeptide shows high binding specificity for glyphosate (KD = 8.6 muM), probably because of the presence of R and D in the oligopeptide.	glyphosate	53-63	latexin	Homo sapiens	74-77
22827807-6	2012	Glyphosate stimulated rhizobacterial growth while having no influence on saprotrophic fungi, suggesting a greater abundance of glyphosate-tolerant 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) in bacteria than in fungi.	glyphosate	127-137	3-phosphoshikimate 1-carboxyvinyltransferase 2	Triticum aestivum	147-190
23099315-5	2013	Bcl-1 intensity decreased while Bax intensity increased with exposure to increasing TN-20 and/or glyphosate concentrations.	glyphosate	97-107	BCL2 associated X, apoptosis regulator	Rattus norvegicus	32-35
24502134-7	2013	Presenting adverse effects of glyphosate and its formulations we focused on the role of glyphosate formulations in hormonal disorders by impeding the expression of steroidogenic acute regulatory protein and the inhibition of aromatase activity.	glyphosate	88-98	steroidogenic acute regulatory protein	Homo sapiens	164-202
22715408-0	2012	A novel 5-enolpyruvylshikimate-3-phosphate synthase shows high glyphosate tolerance in Escherichia coli and tobacco plants.	glyphosate	63-73	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	8-51
22504123-5	2012	Interestingly, deactivation of Beclin-1 gene attenuated both apoptosis and autophagy in glyphosate treated differentiated PC12 cells, suggesting that Beclin-1 gene is involved in the crosstalk between the two mechanisms.	glyphosate	88-98	beclin 1	Rattus norvegicus	31-39
22504123-5	2012	Interestingly, deactivation of Beclin-1 gene attenuated both apoptosis and autophagy in glyphosate treated differentiated PC12 cells, suggesting that Beclin-1 gene is involved in the crosstalk between the two mechanisms.	glyphosate	88-98	beclin 1	Rattus norvegicus	150-158
22715408-1	2012	A key enzyme in the shikimate pathway, 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the primary target of the broad-spectrum herbicide glyphosate.	glyphosate	145-155	3-phosphoshikimate 1-carboxyvinyltransferase 1, chloroplastic	Nicotiana tabacum	39-82
20180575-0	2010	Glyphosate effect on shikimate, nitrate reductase activity, yield, and seed composition in corn.	glyphosate	0-10	nitrate reductase [NADH] 1	Zea mays	32-49
20433928-6	2010	The hLF expression cassette was constructed into a T-DNA containing the RNA interference cassette suppressing the expression of the rice gene CYP81A6 which detoxifies herbicide bentazon, and the 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) cassette which confers to glyphosate tolerance.	glyphosate	273-283	HLF transcription factor, PAR bZIP family member	Homo sapiens	4-7
21859351-5	2011	The results indicated that serum AST, ALT, BUN, and creatinine levels significantly increased in mice treated with glyphosate alone compared with the other groups (P<.05).	glyphosate	115-125	solute carrier family 17 (anion/sugar transporter), member 5	Mus musculus	33-36
21859351-5	2011	The results indicated that serum AST, ALT, BUN, and creatinine levels significantly increased in mice treated with glyphosate alone compared with the other groups (P<.05).	glyphosate	115-125	glutamic pyruvic transaminase, soluble	Mus musculus	38-41
21338087-3	2011	This paper compares an HPLC and two spectrophotometric methods (Spec 1 and Spec 2) and assesses the effectiveness in the detection of shikimic acid in the tissues of glyphosate-treated plants.	glyphosate	166-176	CDC42 small effector 1	Homo sapiens	64-70
21338087-3	2011	This paper compares an HPLC and two spectrophotometric methods (Spec 1 and Spec 2) and assesses the effectiveness in the detection of shikimic acid in the tissues of glyphosate-treated plants.	glyphosate	166-176	CDC42 small effector 2	Homo sapiens	75-81
21338087-7	2011	All three methods were specific to shikimic acid and detected the compound in the tissues of glyphosate-susceptible crops, increasing exponentially in concentration within 24 h of glyphosate application and plateauing at approximately 72 h. Spec 1 estimated more shikimic acid in identical plant extract samples compared to Spec 2 and, likewise, HPLC detection was more effective than spectrophotometric determinations.	glyphosate	93-103	CDC42 small effector 1	Homo sapiens	241-247
20180575-11	2010	Yet, nitrate reductase activity was reduced 5-19% with glyphosate at 840 + 840 g/ha rate and 8-42% with glyphosate at 1260 + 1260 g/ha rate in both GR and GR stacked corn.	glyphosate	55-65	nitrate reductase [NADH] 1	Zea mays	5-22
20180575-11	2010	Yet, nitrate reductase activity was reduced 5-19% with glyphosate at 840 + 840 g/ha rate and 8-42% with glyphosate at 1260 + 1260 g/ha rate in both GR and GR stacked corn.	glyphosate	104-114	nitrate reductase [NADH] 1	Zea mays	5-22
19211556-0	2009	Structural basis of glyphosate resistance resulting from the double mutation Thr97 -> Ile and Pro101 -> Ser in 5-enolpyruvylshikimate-3-phosphate synthase from Escherichia coli.	glyphosate	20-30	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	117-160
21784030-6	2009	The second aim of this study to investigate how glyphosate alone or included in herbicide Roundup affected hepatic reduced glutathione (GSH) and lipid peroxidation (LPO) levels of animals as an index of antioxidant status and oxidative stress, respectively, as well as the serum nitric oxide (NO) and alpha tumour necrosis factor (TNF-alpha) were measured.	glyphosate	48-58	tumor necrosis factor	Rattus norvegicus	331-340
19211556-1	2009	The shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the target of the broad spectrum herbicide glyphosate.	glyphosate	127-137	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	29-72
19211556-1	2009	The shikimate pathway enzyme 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS) is the target of the broad spectrum herbicide glyphosate.	glyphosate	127-137	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	74-79
19211556-2	2009	The genetic engineering of EPSPS led to the introduction of glyphosate-resistant crops worldwide.	glyphosate	60-70	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	27-32
19211556-4	2009	CP4 EPSPS, expressed in NK603 corn and transgenic soybean, cotton, and canola, belongs to class II EPSPS, glyphosate-insensitive variants of this enzyme isolated from certain Gram-positive bacteria.	glyphosate	106-116	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	4-9
19211556-4	2009	CP4 EPSPS, expressed in NK603 corn and transgenic soybean, cotton, and canola, belongs to class II EPSPS, glyphosate-insensitive variants of this enzyme isolated from certain Gram-positive bacteria.	glyphosate	106-116	3-phosphoshikimate 1-carboxyvinyltransferase 2	Gossypium hirsutum	99-104
19211556-5	2009	GA21 corn, on the other hand, was created by point mutations of class I EPSPS, such as the enzymes from Zea mays or Escherichia coli, which are sensitive to low glyphosate concentrations.	glyphosate	161-171	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	72-77
19211556-9	2009	The crystal structure at 1.7-A resolution revealed that the dual mutation causes a shift of residue Gly(96) toward the glyphosate binding site, impairing efficient binding of glyphosate, while the side chain of Ile(97) points away from the substrate binding site, facilitating PEP utilization.	glyphosate	119-129	phosphoenolpyruvate carboxylase 2	Zea mays	277-280
19211556-9	2009	The crystal structure at 1.7-A resolution revealed that the dual mutation causes a shift of residue Gly(96) toward the glyphosate binding site, impairing efficient binding of glyphosate, while the side chain of Ile(97) points away from the substrate binding site, facilitating PEP utilization.	glyphosate	175-185	phosphoenolpyruvate carboxylase 2	Zea mays	277-280
19211556-10	2009	The single site T97I mutation renders the enzyme sensitive to glyphosate and causes a substantial decrease in the affinity for PEP.	glyphosate	62-72	phosphoenolpyruvate carboxylase 2	Zea mays	127-130
19211556-11	2009	Thus, only the concomitant mutations of Thr(97) and Pro(101) induce the conformational changes necessary to produce catalytically efficient, glyphosate-resistant class I EPSPS.	glyphosate	141-151	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	170-175
16766672-8	2006	A similar reorientation of microtubules was also observed in Arabidopsis (Arabidopsis thaliana) seedlings expressing green fluorescent protein tubulin (tubulin alpha 6) following glyphosate treatment.	glyphosate	179-189	Tubulin/FtsZ family protein	Arabidopsis thaliana	152-167
18363356-4	2008	However, there were significant effects of glyphosate application on nitrogen assimilation, as measured by in vivo nitrate reductase activity (NRA) in leaves, roots, and nodules, especially at high rate.	glyphosate	43-53	inducible nitrate reductase [NADH] 1	Glycine max	115-132
18172892-2	2008	RESULTS: A gene encoding a glyphosate-tolerant EPSP synthase (aroA(1398)) from bacterial strain ATX1398 was cloned and characterized.	glyphosate	27-37	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	47-60
18172892-5	2008	The full-length enzyme is 800-fold more resistant to glyphosate than the maize EPSP synthase while retaining high affinity for the substrate phosphoenol pyruvate.	glyphosate	53-63	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	79-92
18035550-0	2008	In vitro study on the binding of herbicide glyphosate to human serum albumin by optical spectroscopy and molecular modeling.	glyphosate	43-53	albumin	Homo sapiens	63-76
18035550-1	2008	In this study, the interaction mechanism of herbicide glyphosate and human serum albumin (HSA) has been characterized by fluorescence, UV, Fourier transform infrared (FT-IR), Circular dichroism (CD) spectroscopic and molecular modeling methods.	glyphosate	54-64	albumin	Homo sapiens	75-88
21783682-2	2006	Our results showed that glyphosate alone or included in Roundup 3 plus( ), induced significant changes in cellular antioxidant status as a glutathione depletion, enzymatic (catalase, glutathione-peroxidase and superoxide dismutase) disorders, and increased lipid peroxidation.	glyphosate	24-34	catalase	Homo sapiens	173-181
16569053-7	2006	On the basis of the role of shikimic acid and PCA in the regulation of PEPC, as potent competitive inhibitors, this additional effect provoked by glyphosate on 5-enolpyruvylshikimic-3-phosphate synthase enzyme (EPSPS; EC 2.5.1.19) inhibition would divert most PEP into the shikimate pathway, depriving energy substrates to bacteroids to maintain nitrogen fixation.	glyphosate	146-156	phosphoenolpyruvate carboxykinase 1	Homo sapiens	71-75
16569053-7	2006	On the basis of the role of shikimic acid and PCA in the regulation of PEPC, as potent competitive inhibitors, this additional effect provoked by glyphosate on 5-enolpyruvylshikimic-3-phosphate synthase enzyme (EPSPS; EC 2.5.1.19) inhibition would divert most PEP into the shikimate pathway, depriving energy substrates to bacteroids to maintain nitrogen fixation.	glyphosate	146-156	progestagen associated endometrial protein	Homo sapiens	71-74
16547651-2	2006	Glyphosate affects aromatic amino acid biosynthesis by inhibiting 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	66-109
16547651-2	2006	Glyphosate affects aromatic amino acid biosynthesis by inhibiting 5-enolpyruvylshikimate-3-phosphate synthase (EPSPS).	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	111-116
16547651-9	2006	Glyphosate-tolerant crops with EPSPS transgene alone or both EPSPS and gox transgenes have been commercialized.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	31-36
16547651-9	2006	Glyphosate-tolerant crops with EPSPS transgene alone or both EPSPS and gox transgenes have been commercialized.	glyphosate	0-10	3-phosphoshikimate 1-carboxyvinyltransferase 2	Zea mays	61-66