PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 2912573-1 1989 The potential for 4-aminobiphenyl (4-ABP) to be transferred from circulating blood into the milk of lactating Sprague-Dawley rats was determined. 4-biphenylamine 18-33 amine oxidase, copper containing 1 Rattus norvegicus 37-40 3390806-2 1988 Since this mutagen is structurally similar to the multipotent carcinogen, 4-aminobiphenyl (4-ABP), we compared their relative tumorigenic activity in the neonatal male B6C3F1 mouse. 4-biphenylamine 74-89 secretoglobin, family 1B, member 27 Mus musculus 93-96 2908851-0 1989 Metabolic oxidation of the carcinogens 4-aminobiphenyl and 4,4"-methylene-bis(2-chloroaniline) by human hepatic microsomes and by purified rat hepatic cytochrome P-450 monooxygenases. 4-biphenylamine 39-54 cytochrome P450 family 4 subfamily F member 3 Homo sapiens 151-167 33620775-2 2021 In bladder cancer, a unique distribution of mutations amongst several codons of TP53 has been hypothesised to be caused by environmental carcinogens including 4-aminobiphenyl (4-ABP). 4-biphenylamine 159-174 tumor protein p53 Homo sapiens 80-84 33847444-5 2021 Furthermore, we proved that inhibition of cytochrome P450 2E1 (CYP2E1) expression by propolis could contribute to the decreased oxidative DNA damage in the treated cells, as the conversion of 4-ABP into its metabolite, N-hydroxy-ABP (HOABP), was blocked; after all, HOABP showed more genotoxic than its parent chemical, 4-ABP. 4-biphenylamine 192-197 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 42-61 33847444-5 2021 Furthermore, we proved that inhibition of cytochrome P450 2E1 (CYP2E1) expression by propolis could contribute to the decreased oxidative DNA damage in the treated cells, as the conversion of 4-ABP into its metabolite, N-hydroxy-ABP (HOABP), was blocked; after all, HOABP showed more genotoxic than its parent chemical, 4-ABP. 4-biphenylamine 192-197 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 63-69 33847444-5 2021 Furthermore, we proved that inhibition of cytochrome P450 2E1 (CYP2E1) expression by propolis could contribute to the decreased oxidative DNA damage in the treated cells, as the conversion of 4-ABP into its metabolite, N-hydroxy-ABP (HOABP), was blocked; after all, HOABP showed more genotoxic than its parent chemical, 4-ABP. 4-biphenylamine 320-325 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 42-61 33847444-5 2021 Furthermore, we proved that inhibition of cytochrome P450 2E1 (CYP2E1) expression by propolis could contribute to the decreased oxidative DNA damage in the treated cells, as the conversion of 4-ABP into its metabolite, N-hydroxy-ABP (HOABP), was blocked; after all, HOABP showed more genotoxic than its parent chemical, 4-ABP. 4-biphenylamine 320-325 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 63-69 33847444-9 2021 In conclusion, propolis could antagonize 4-ABP-induced oxidative DNA damage though the removal of ROS and inhibition of CYP2E1 expression in the treated cells. 4-biphenylamine 41-46 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 120-126 3198197-1 1988 In a population-based study in Turin, Italy, smokers of blond tobacco showed 4-aminobiphenyl (4-ABP) adduct levels some three times higher than nonsmoking subjects, and smokers of black tobacco showed levels about five times greater than nonsmokers. 4-biphenylamine 77-92 auxin-binding protein T92 Nicotiana tabacum 96-99 3791245-1 1987 A quantitative method has been developed for the analysis of 4-aminobiphenyl (4-ABP) covalently bound as the sulfinic acid amide to the 93 beta cysteine of human hemoglobin. 4-biphenylamine 61-76 amine oxidase copper containing 1 Homo sapiens 80-83 6545277-1 1984 The feasibility of monitoring exposure to 4-aminobiphenyl (4-ABP) was determined by measuring the formation of covalent blood protein adducts in rats following administration of the amine. 4-biphenylamine 42-57 amine oxidase, copper containing 1 Rattus norvegicus 61-64 33620775-2 2021 In bladder cancer, a unique distribution of mutations amongst several codons of TP53 has been hypothesised to be caused by environmental carcinogens including 4-aminobiphenyl (4-ABP). 4-biphenylamine 176-181 tumor protein p53 Homo sapiens 80-84 33620775-12 2021 In conclusion, the observed difference in the N-OH-4-ABP-induced TP53 mutation spectrum to that observed in human bladder tumours do not support a role of 4-ABP in human bladder cancer development. 4-biphenylamine 51-56 tumor protein p53 Homo sapiens 65-69 33136180-6 2021 Benzidine, 3,4-DMA, and 2-AF were preferential human NAT1 substrates, while 3,5-DMA, 2,5-DMA, 3-EA, and ABP were preferential human NAT2 substrates. 4-biphenylamine 104-107 N-acetyltransferase 2 Homo sapiens 132-136 33399867-12 2020 Cyp1a1, 1a2 and 1b1 are required to metabolise PhIP and 4-ABP. 4-biphenylamine 56-61 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 0-6 32905825-4 2020 In addition, we found that miR-513a-5p-induced by 4-ABP could suppress p53 expression and HR repair activity. 4-biphenylamine 50-55 tumor protein p53 Homo sapiens 71-74 32905825-5 2020 On the other hand, the levels of p53, miR-513a-5p, and gammaH2AX were attenuated by 5 mM N-acetyl-l-cysteine (NAC) pretreatment, indicating that the reactive oxygen species (ROS)-dependent p53-miR-513a-5p was involved in DSB repair in 4-ABP-treated cells. 4-biphenylamine 235-240 tumor protein p53 Homo sapiens 33-36 32905825-6 2020 These findings indicated that the ROS/p53/miR-513a-5p/p53 loop axis plays a relevant role in regulating HR repair which may facilitate our understanding of molecular mechanisms regarding how miR-513a-5p impacts DSB repair in 4-ABP-treated cells. 4-biphenylamine 225-230 tumor protein p53 Homo sapiens 38-41 32905825-6 2020 These findings indicated that the ROS/p53/miR-513a-5p/p53 loop axis plays a relevant role in regulating HR repair which may facilitate our understanding of molecular mechanisms regarding how miR-513a-5p impacts DSB repair in 4-ABP-treated cells. 4-biphenylamine 225-230 tumor protein p53 Homo sapiens 54-57 31490564-4 2020 ABP and AF both caused significantly (P < 0.001) greater mutagenesis measured at the hypoxanthine phosphoribosyl transferase (hprt) locus in the UV5/CYP1A2/NAT2*4 acetylator cell line compared to the UV5, UV5/CYP1A2, and UV5/CYP1A2/NAT2*5B cell lines. 4-biphenylamine 0-3 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 85-124 32433928-1 2020 4-Aminobiphenyl (4-ABP), a well-known human carcinogen, has been shown to cause oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 microM-300 microM for 24 h. However, the underlying mechanism regarding the epigenetic regulation of miR-630 on DNA damage repair in liver cells is still not understood and needs to be investigated. 4-biphenylamine 0-15 microRNA 630 Homo sapiens 112-119 32433928-1 2020 4-Aminobiphenyl (4-ABP), a well-known human carcinogen, has been shown to cause oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 microM-300 microM for 24 h. However, the underlying mechanism regarding the epigenetic regulation of miR-630 on DNA damage repair in liver cells is still not understood and needs to be investigated. 4-biphenylamine 0-15 microRNA 630 Homo sapiens 266-273 32433928-1 2020 4-Aminobiphenyl (4-ABP), a well-known human carcinogen, has been shown to cause oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 microM-300 microM for 24 h. However, the underlying mechanism regarding the epigenetic regulation of miR-630 on DNA damage repair in liver cells is still not understood and needs to be investigated. 4-biphenylamine 17-22 microRNA 630 Homo sapiens 112-119 32433928-1 2020 4-Aminobiphenyl (4-ABP), a well-known human carcinogen, has been shown to cause oxidative DNA damage and induce miR-630 expression in HepG2 cells treated with 18.75 microM-300 microM for 24 h. However, the underlying mechanism regarding the epigenetic regulation of miR-630 on DNA damage repair in liver cells is still not understood and needs to be investigated. 4-biphenylamine 17-22 microRNA 630 Homo sapiens 266-273 31490564-4 2020 ABP and AF both caused significantly (P < 0.001) greater mutagenesis measured at the hypoxanthine phosphoribosyl transferase (hprt) locus in the UV5/CYP1A2/NAT2*4 acetylator cell line compared to the UV5, UV5/CYP1A2, and UV5/CYP1A2/NAT2*5B cell lines. 4-biphenylamine 0-3 hypoxanthine-guanine phosphoribosyltransferase Cricetulus griseus 126-130 31490564-4 2020 ABP and AF both caused significantly (P < 0.001) greater mutagenesis measured at the hypoxanthine phosphoribosyl transferase (hprt) locus in the UV5/CYP1A2/NAT2*4 acetylator cell line compared to the UV5, UV5/CYP1A2, and UV5/CYP1A2/NAT2*5B cell lines. 4-biphenylamine 0-3 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 149-155 31490564-4 2020 ABP and AF both caused significantly (P < 0.001) greater mutagenesis measured at the hypoxanthine phosphoribosyl transferase (hprt) locus in the UV5/CYP1A2/NAT2*4 acetylator cell line compared to the UV5, UV5/CYP1A2, and UV5/CYP1A2/NAT2*5B cell lines. 4-biphenylamine 0-3 N-acetyltransferase 2 Homo sapiens 156-160 31490564-4 2020 ABP and AF both caused significantly (P < 0.001) greater mutagenesis measured at the hypoxanthine phosphoribosyl transferase (hprt) locus in the UV5/CYP1A2/NAT2*4 acetylator cell line compared to the UV5, UV5/CYP1A2, and UV5/CYP1A2/NAT2*5B cell lines. 4-biphenylamine 0-3 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 209-215 31490564-4 2020 ABP and AF both caused significantly (P < 0.001) greater mutagenesis measured at the hypoxanthine phosphoribosyl transferase (hprt) locus in the UV5/CYP1A2/NAT2*4 acetylator cell line compared to the UV5, UV5/CYP1A2, and UV5/CYP1A2/NAT2*5B cell lines. 4-biphenylamine 0-3 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 209-215 31490564-4 2020 ABP and AF both caused significantly (P < 0.001) greater mutagenesis measured at the hypoxanthine phosphoribosyl transferase (hprt) locus in the UV5/CYP1A2/NAT2*4 acetylator cell line compared to the UV5, UV5/CYP1A2, and UV5/CYP1A2/NAT2*5B cell lines. 4-biphenylamine 0-3 N-acetyltransferase 2 Homo sapiens 232-236 31490564-5 2020 ABP- and AF-induced hprt mutant cDNAs were sequenced and over 80% of the single-base substitutions were at G:C base pairs. 4-biphenylamine 0-3 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 20-24 31490564-7 2020 DNA damage and adduct levels were dose-dependent, correlated highly with levels of hprt mutants, and were significantly (P < 0.0001) greater in the UV5/CYP1A2/NAT2*4 rapid acetylator cell line following treatment with ABP or AF as compared to all other cell lines. 4-biphenylamine 218-221 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 152-158 31490564-7 2020 DNA damage and adduct levels were dose-dependent, correlated highly with levels of hprt mutants, and were significantly (P < 0.0001) greater in the UV5/CYP1A2/NAT2*4 rapid acetylator cell line following treatment with ABP or AF as compared to all other cell lines. 4-biphenylamine 218-221 N-acetyltransferase 2 Homo sapiens 159-163 29709872-1 2018 4-Aminobiphenyl (4-ABP) which is primarily formed during tobacco combustion and overheated meat is a major carcinogen responsible for various cancers. 4-biphenylamine 0-15 auxin-binding protein T92 Nicotiana tabacum 19-22 31203411-0 2019 Bioactivation of the tobacco carcinogens 4-aminobiphenyl (4-ABP) and 2-amino-9H-pyrido[2,3-b]indole (AalphaC) in human bladder RT4 cells. 4-biphenylamine 41-56 auxin-binding protein T92 Nicotiana tabacum 60-63 30306738-13 2018 Because liver expression of both Sult1a1 and Sutl1d1 is suppressed by androgen in male mice, our results suggest that androgen renders bladder more exposed to ABP in male mice by suppressing Sult-mediated ABP metabolism in liver, which increases bladder delivery of carcinogenic metabolites. 4-biphenylamine 159-162 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 33-40 30306738-13 2018 Because liver expression of both Sult1a1 and Sutl1d1 is suppressed by androgen in male mice, our results suggest that androgen renders bladder more exposed to ABP in male mice by suppressing Sult-mediated ABP metabolism in liver, which increases bladder delivery of carcinogenic metabolites. 4-biphenylamine 205-208 sulfotransferase family 1A, phenol-preferring, member 1 Mus musculus 33-40 31695756-2 2019 KGN can be cleaved into 4-aminobiphenyl (4-ABP) and phthalic acid (PA) following enzymolysis of an amide bond. 4-biphenylamine 24-39 amine oxidase, copper-containing 1 Mus musculus 43-46 31203411-1 2019 Occupational and tobacco exposure to aromatic amines (AAs) including 4-aminobiphenyl (4-ABP) and 2-naphthylamine (2-NA) are associated with bladder cancer (BC) risk. 4-biphenylamine 69-84 auxin-binding protein T92 Nicotiana tabacum 88-91 28523442-9 2017 The apparent V max of the novel recombinant NAT2 allozymes NAT2 6C, NAT2 14C, NAT2 14D, and NAT2 14E towards AF, 4-aminobiphenyl (ABP), and 3,2"-dimethyl-4-aminobiphenyl (DMABP) were each significantly (p < 0.001) lower while their apparent K m values did not differ significantly (p > 0.05) from recombinant NAT2 4. 4-biphenylamine 130-133 N-acetyltransferase 2 Homo sapiens 44-48 29061807-11 2017 RESULTS: The present study reports the structural binding of ABP and BZ with LPO using in silico approaches. 4-biphenylamine 61-64 lactoperoxidase Homo sapiens 77-80 29061807-13 2017 CONCLUSION: Both ABP and BZ were placed in the substrate binding site present in the distal heme cavity of LPO with good affinity. 4-biphenylamine 17-20 lactoperoxidase Homo sapiens 107-110 29071010-9 2017 TLS efficiency and error-proneness are affected by the sequences surrounding the adduct, as demonstrated in our previous study on an ABP adduct, N-(2"-deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-ABP). 4-biphenylamine 133-136 FUS RNA binding protein Homo sapiens 0-3 28523442-9 2017 The apparent V max of the novel recombinant NAT2 allozymes NAT2 6C, NAT2 14C, NAT2 14D, and NAT2 14E towards AF, 4-aminobiphenyl (ABP), and 3,2"-dimethyl-4-aminobiphenyl (DMABP) were each significantly (p < 0.001) lower while their apparent K m values did not differ significantly (p > 0.05) from recombinant NAT2 4. 4-biphenylamine 130-133 N-acetyltransferase 2 Homo sapiens 59-63 28523442-9 2017 The apparent V max of the novel recombinant NAT2 allozymes NAT2 6C, NAT2 14C, NAT2 14D, and NAT2 14E towards AF, 4-aminobiphenyl (ABP), and 3,2"-dimethyl-4-aminobiphenyl (DMABP) were each significantly (p < 0.001) lower while their apparent K m values did not differ significantly (p > 0.05) from recombinant NAT2 4. 4-biphenylamine 130-133 N-acetyltransferase 2 Homo sapiens 59-63 28523442-9 2017 The apparent V max of the novel recombinant NAT2 allozymes NAT2 6C, NAT2 14C, NAT2 14D, and NAT2 14E towards AF, 4-aminobiphenyl (ABP), and 3,2"-dimethyl-4-aminobiphenyl (DMABP) were each significantly (p < 0.001) lower while their apparent K m values did not differ significantly (p > 0.05) from recombinant NAT2 4. 4-biphenylamine 130-133 N-acetyltransferase 2 Homo sapiens 59-63 28523442-9 2017 The apparent V max of the novel recombinant NAT2 allozymes NAT2 6C, NAT2 14C, NAT2 14D, and NAT2 14E towards AF, 4-aminobiphenyl (ABP), and 3,2"-dimethyl-4-aminobiphenyl (DMABP) were each significantly (p < 0.001) lower while their apparent K m values did not differ significantly (p > 0.05) from recombinant NAT2 4. 4-biphenylamine 130-133 N-acetyltransferase 2 Homo sapiens 59-63 28523442-9 2017 The apparent V max of the novel recombinant NAT2 allozymes NAT2 6C, NAT2 14C, NAT2 14D, and NAT2 14E towards AF, 4-aminobiphenyl (ABP), and 3,2"-dimethyl-4-aminobiphenyl (DMABP) were each significantly (p < 0.001) lower while their apparent K m values did not differ significantly (p > 0.05) from recombinant NAT2 4. 4-biphenylamine 130-133 N-acetyltransferase 2 Homo sapiens 59-63 28493705-3 2017 A novel nanoflow liquid chromatography/ion trap multistage mass spectrometry (nanoLC-IT/MS3) method was established to assess exposure to AalphaC and the tobacco-associated bladder carcinogen 4-aminobiphenyl (4-ABP) through their Hb sulfinamide adducts. 4-biphenylamine 192-207 TRAP Homo sapiens 43-47 27746196-6 2016 Exposure of adult mice to ABP, DEN or CCl4 produced a 2-fold greater acute elevation in serum levels of the hepatotoxicity biomarker alanine aminotransferase (ALT) in males than in females, while levels of the inflammatory biomarker interleukin-6 (IL-6) showed no sex difference. 4-biphenylamine 26-29 glutamic pyruvic transaminase, soluble Mus musculus 133-157 27746196-6 2016 Exposure of adult mice to ABP, DEN or CCl4 produced a 2-fold greater acute elevation in serum levels of the hepatotoxicity biomarker alanine aminotransferase (ALT) in males than in females, while levels of the inflammatory biomarker interleukin-6 (IL-6) showed no sex difference. 4-biphenylamine 26-29 glutamic pyruvic transaminase, soluble Mus musculus 159-162 27746196-6 2016 Exposure of adult mice to ABP, DEN or CCl4 produced a 2-fold greater acute elevation in serum levels of the hepatotoxicity biomarker alanine aminotransferase (ALT) in males than in females, while levels of the inflammatory biomarker interleukin-6 (IL-6) showed no sex difference. 4-biphenylamine 26-29 interleukin 6 Mus musculus 233-246 26840026-2 2016 Certain AAs, such as 4-aminobiphenyl (4-ABP), are human carcinogens that require enzymatic metabolic activation to reactive chemicals to form genotoxic DNA adducts. 4-biphenylamine 21-36 amine oxidase copper containing 1 Homo sapiens 40-43 27746196-6 2016 Exposure of adult mice to ABP, DEN or CCl4 produced a 2-fold greater acute elevation in serum levels of the hepatotoxicity biomarker alanine aminotransferase (ALT) in males than in females, while levels of the inflammatory biomarker interleukin-6 (IL-6) showed no sex difference. 4-biphenylamine 26-29 interleukin 6 Mus musculus 248-252 27746196-7 2016 However, treatment of immature mice with either ABP or DEN using standard tumor-inducing postnatal exposure protocols produced no increase in serum ALT or IL-6 levels in either males or females, while CCl4 produced a 40-fold ALT elevation but with no sex difference. 4-biphenylamine 48-51 glutamic pyruvic transaminase, soluble Mus musculus 225-228 25596734-7 2015 Indeed, liver expression of ABP-metabolizing human UGT1A3 transgene in mice increases bladder susceptibility to ABP. 4-biphenylamine 28-31 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 51-57 25922528-4 2015 However, Cyp1a2(-/-) mice still possess significant liver ABP N-hydroxylation activity, DNA damage, and incidence of ABP-induced liver tumors, and in vivo induction of CYP1A2 paradoxically reduces levels of ABP-induced DNA damage. 4-biphenylamine 58-61 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 9-15 25922528-4 2015 However, Cyp1a2(-/-) mice still possess significant liver ABP N-hydroxylation activity, DNA damage, and incidence of ABP-induced liver tumors, and in vivo induction of CYP1A2 paradoxically reduces levels of ABP-induced DNA damage. 4-biphenylamine 58-61 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 168-174 25922528-4 2015 However, Cyp1a2(-/-) mice still possess significant liver ABP N-hydroxylation activity, DNA damage, and incidence of ABP-induced liver tumors, and in vivo induction of CYP1A2 paradoxically reduces levels of ABP-induced DNA damage. 4-biphenylamine 117-120 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 9-15 25922528-4 2015 However, Cyp1a2(-/-) mice still possess significant liver ABP N-hydroxylation activity, DNA damage, and incidence of ABP-induced liver tumors, and in vivo induction of CYP1A2 paradoxically reduces levels of ABP-induced DNA damage. 4-biphenylamine 117-120 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 168-174 25922528-8 2015 In addition, recombinant mouse CYP1A2 and CYP2E1 were both able to N-hydroxylate ABP in mouse hepatoma cells. 4-biphenylamine 81-84 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 31-37 25922528-8 2015 In addition, recombinant mouse CYP1A2 and CYP2E1 were both able to N-hydroxylate ABP in mouse hepatoma cells. 4-biphenylamine 81-84 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 42-48 25922528-9 2015 However, the in vivo clearance of ABP was significantly reduced in Cyp1a2(-/-) but not in Cyp2e1(-/-) mice. 4-biphenylamine 34-37 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 67-73 25922528-10 2015 Our results support a significant role for CYP2E1 as a novel ABP N-oxidizing enzyme in adult mice, and suggest a more important contribution of CYP1A2 to the in vivo plasma clearance and thus detoxification of ABP. 4-biphenylamine 61-64 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 43-49 25601990-7 2015 Isozyme-selective inhibition experiments using liver microsomes from wild-type and genetically modified mice identified CYP2E1 as a major ABP N-hydroxylating enzyme. 4-biphenylamine 138-141 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 120-126 25601990-11 2015 Our results identify CYP2E1 as a novel ABP-N-oxidizing enzyme, and suggest that sex differences in CYP2E1-dependent oxidative stress and antioxidant responses to ABP may contribute to the observed sex difference in tumor incidence. 4-biphenylamine 39-42 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 21-27 25601990-11 2015 Our results identify CYP2E1 as a novel ABP-N-oxidizing enzyme, and suggest that sex differences in CYP2E1-dependent oxidative stress and antioxidant responses to ABP may contribute to the observed sex difference in tumor incidence. 4-biphenylamine 39-42 cytochrome P450, family 2, subfamily e, polypeptide 1 Mus musculus 99-105 25596734-7 2015 Indeed, liver expression of ABP-metabolizing human UGT1A3 transgene in mice increases bladder susceptibility to ABP. 4-biphenylamine 112-115 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 51-57 24857880-1 2014 We examined the role of miRNAs in DNA damage response in HepG2 cells following exposure to 4-aminobiphenyl (4-ABP). 4-biphenylamine 91-106 amine oxidase copper containing 1 Homo sapiens 110-113 24939871-2 2014 Two components in TS, 4-aminobiphenyl (4-ABP) and acrolein, which also are environmental contaminants, can cause bladder tumor in rat models. 4-biphenylamine 22-37 amine oxidase, copper containing 1 Rattus norvegicus 41-44 23382838-2 2013 4-Aminobiphenyl (4-ABP) and several other related arylamines have been shown to be causally involved in the induction of human urinary bladder cancers. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 19-22 23682735-8 2013 The N-hydroxylamines of 4-aminobiphenyl (4-ABP), 2-naphthylamine (2-NA), and 2-aminofluorene (2-AF) were synthesized and found to be reduced by P450 2S1 under both anaerobic and aerobic conditions. 4-biphenylamine 24-39 amine oxidase copper containing 1 Homo sapiens 43-46 22475078-5 2012 The calculations provided SAR-like information that was able guide the design of further examples of 4-aminobiphenyls that are not active in the Ames test. 4-biphenylamine 101-117 sarcosine dehydrogenase Homo sapiens 26-29 22508569-1 2012 One model for cancer initiation by 4-aminobiphenyl (ABP) involves N-oxidation by cytochrome P450 CYP1A2 followed by O-conjugation by N-acetyltransferase(s) NAT1 and/or NAT2 and decomposition to a DNA-binding nitrenium ion. 4-biphenylamine 35-50 N-acetyl transferase 1 Mus musculus 156-160 22508569-1 2012 One model for cancer initiation by 4-aminobiphenyl (ABP) involves N-oxidation by cytochrome P450 CYP1A2 followed by O-conjugation by N-acetyltransferase(s) NAT1 and/or NAT2 and decomposition to a DNA-binding nitrenium ion. 4-biphenylamine 35-50 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 168-172 22508569-1 2012 One model for cancer initiation by 4-aminobiphenyl (ABP) involves N-oxidation by cytochrome P450 CYP1A2 followed by O-conjugation by N-acetyltransferase(s) NAT1 and/or NAT2 and decomposition to a DNA-binding nitrenium ion. 4-biphenylamine 52-55 N-acetyl transferase 1 Mus musculus 156-160 22508569-1 2012 One model for cancer initiation by 4-aminobiphenyl (ABP) involves N-oxidation by cytochrome P450 CYP1A2 followed by O-conjugation by N-acetyltransferase(s) NAT1 and/or NAT2 and decomposition to a DNA-binding nitrenium ion. 4-biphenylamine 52-55 N-acetyltransferase 2 (arylamine N-acetyltransferase) Mus musculus 168-172 22508569-9 2012 These results suggest that observed sex- and NAT-dependent differences in ABP-induced liver tumor incidence in mice are not due to differences in either mutation rates or mutational spectra, and that mechanisms independent of carcinogen bioactivation, covalent DNA binding and mutation may be responsible for these differences. 4-biphenylamine 74-77 solute carrier family 38, member 3 Mus musculus 45-48 21837760-1 2012 N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). 4-biphenylamine 170-173 N-acetyltransferase 1 Homo sapiens 0-21 21837760-1 2012 N-acetyltransferase 1 (NAT1) is a phase II metabolic enzyme responsible for the biotransformation of aromatic and heterocyclic amine carcinogens such as 4-aminobiphenyl (ABP). 4-biphenylamine 170-173 N-acetyltransferase 1 Homo sapiens 23-27 21837760-8 2012 Consistent with NAT1 expression and activity, ABP-induced DNA adducts and hypoxanthine phosphoribosyl transferase mutants were significantly higher (P < 0.05) in NATb/NAT1*4 than in NATa/NAT1*4 transfected cells following exposure to ABP. 4-biphenylamine 46-49 N-acetyltransferase 1 Homo sapiens 16-20 21837760-8 2012 Consistent with NAT1 expression and activity, ABP-induced DNA adducts and hypoxanthine phosphoribosyl transferase mutants were significantly higher (P < 0.05) in NATb/NAT1*4 than in NATa/NAT1*4 transfected cells following exposure to ABP. 4-biphenylamine 46-49 N-acetyltransferase 1 Homo sapiens 170-174 21837760-8 2012 Consistent with NAT1 expression and activity, ABP-induced DNA adducts and hypoxanthine phosphoribosyl transferase mutants were significantly higher (P < 0.05) in NATb/NAT1*4 than in NATa/NAT1*4 transfected cells following exposure to ABP. 4-biphenylamine 46-49 N-acetyltransferase 1 Homo sapiens 170-174 21837760-8 2012 Consistent with NAT1 expression and activity, ABP-induced DNA adducts and hypoxanthine phosphoribosyl transferase mutants were significantly higher (P < 0.05) in NATb/NAT1*4 than in NATa/NAT1*4 transfected cells following exposure to ABP. 4-biphenylamine 237-240 N-acetyltransferase 1 Homo sapiens 170-174 21837760-8 2012 Consistent with NAT1 expression and activity, ABP-induced DNA adducts and hypoxanthine phosphoribosyl transferase mutants were significantly higher (P < 0.05) in NATb/NAT1*4 than in NATa/NAT1*4 transfected cells following exposure to ABP. 4-biphenylamine 237-240 N-acetyltransferase 1 Homo sapiens 170-174 22193722-3 2012 At an ABP exposure of 1200 nmol, male Nat1/2(-/-) mice had a liver tumor incidence of 36% compared to 69% in wild-type males, and at 600 nmol there was a complete absence of tumors compared to 60% in wild-type mice. 4-biphenylamine 6-9 N-acetyl transferase 1 Mus musculus 38-42 22072616-2 2012 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) is a heterocyclic aromatic amine that is formed in well-done cooked meat, and 4-aminobiphenyl (4-ABP) is an aromatic amine that arises in tobacco smoke and occurs as a contaminant in the atmosphere. 4-biphenylamine 133-148 amine oxidase copper containing 1 Homo sapiens 152-155 21117897-1 2011 BACKGROUND: 4-Aminobiphenyl (4-ABP) and o-toluidine are known human bladder carcinogens, but only 4-ABP-releasing DNA adducts are known. 4-biphenylamine 12-27 amine oxidase copper containing 1 Homo sapiens 31-34 21487034-2 2011 Here we show that Nrf2 faces a dilemma in defense against 4-aminobiphenyl (ABP), a major human bladder carcinogen from tobacco smoke and other environmental sources. 4-biphenylamine 58-73 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 21487034-2 2011 Here we show that Nrf2 faces a dilemma in defense against 4-aminobiphenyl (ABP), a major human bladder carcinogen from tobacco smoke and other environmental sources. 4-biphenylamine 75-78 NFE2 like bZIP transcription factor 2 Homo sapiens 18-22 21487034-3 2011 Although Nrf2 protected mouse liver against ABP (which is metabolically activated in liver), the bladder level of N-(deoxyguanosin-8-yl)-4-aminobiphenyl (dG-C8-ABP), the predominant ABP-DNA adduct formed in bladder cells and tissues, was markedly higher in Nrf2(+/+) mice than in Nrf2(-/-) mice after ABP exposure. 4-biphenylamine 44-47 nuclear factor, erythroid derived 2, like 2 Mus musculus 9-13 21487034-6 2011 Nrf2 promoted conjugation of ABP with glucuronic acid in the liver, increasing urinary excretion of the conjugate. 4-biphenylamine 29-32 nuclear factor, erythroid derived 2, like 2 Mus musculus 0-4 21487034-8 2011 Hence, although higher liver UGT activity may protect the liver against ABP, it increases bladder exposure to ABP. 4-biphenylamine 72-75 solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus 29-32 21487034-9 2011 These findings raise concerns of potential bladder toxicity when Nrf2-activating chemopreventive agents are used in humans exposed to ABP, especially in smokers. 4-biphenylamine 134-137 NFE2 like bZIP transcription factor 2 Homo sapiens 65-69 21487034-10 2011 We further show that 5,6-dihydrocyclopenta[c][1,2]-dithiole-3(4H)-thione (CPDT) significantly inhibits dG-C8-ABP formation in bladder cells and tissues but does not seem to significantly modulate ABP-catalyzing UGT in liver. 4-biphenylamine 109-112 solute carrier family 35 (UDP-galactose transporter), member A2 Mus musculus 211-214 21438718-1 2011 The aromatic amine 4-aminobiphenyl (4-ABP) is present in tobacco smoke. 4-biphenylamine 19-34 auxin-binding protein T92 Nicotiana tabacum 38-41 20810543-4 2010 Comparison between wild-type mice and mice without Nrf2 shows that Nrf2 activation is required by SF for inhibition of ABP-induced DNA damage. 4-biphenylamine 119-122 nuclear factor, erythroid derived 2, like 2 Mus musculus 67-71 19682468-9 2009 ABP-DNA adduct levels correlated very highly (r>0.96) with ABP-induced hprt mutant levels following each treatment. 4-biphenylamine 0-3 hypoxanthine phosphoribosyltransferase 1 Homo sapiens 74-78 20433335-2 2010 The arylamine, 4-aminobiphenyl (4-ABP), has been identified as a human carcinogen. 4-biphenylamine 15-30 amine oxidase copper containing 1 Homo sapiens 34-37 19932483-1 2010 Exposure to 4-aminobiphenyl (4-ABP), an environmental and tobacco smoke carcinogen that targets the bladder urothelium, leads to DNA adduct formation and cancer development [1]. 4-biphenylamine 12-27 auxin-binding protein T92 Nicotiana tabacum 31-34 19274671-1 2009 Metabolites of the human carcinogen 4-aminobiphenyl (4-ABP) form hemoglobin (Hb) adducts, which represent a useful biomarker for exposure. 4-biphenylamine 36-51 amine oxidase copper containing 1 Homo sapiens 55-58 12971805-3 2003 Moreover, a preliminary study linked frequent hair dye usage with elevated levels of DNA adducts of 4-aminobiphenyl (4-ABP) in human epithelial breast cells (Gorlewska, et al. 4-biphenylamine 100-115 amine oxidase copper containing 1 Homo sapiens 119-122 19336562-1 2009 OBJECTIVE: To quantify the relation between secondhand smoking (SHS) and levels of 4-aminobiphenyl (4-ABP; in urine or blood) and SHS and bladder cancer risk in nonsmokers. 4-biphenylamine 83-98 amine oxidase copper containing 1 Homo sapiens 102-105 19086795-3 2009 Five DNA adducts of the tobacco carcinogen 4-aminobiphenyl (4-ABP) were detected in human hepatocytes treated with 4-ABP, and three DNA adducts of the cooked-meat carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) were identified in the livers of rats exposed to MeIQx, by the CNL-MS3 scan mode. 4-biphenylamine 43-58 auxin-binding protein T92 Nicotiana tabacum 62-65 19086795-3 2009 Five DNA adducts of the tobacco carcinogen 4-aminobiphenyl (4-ABP) were detected in human hepatocytes treated with 4-ABP, and three DNA adducts of the cooked-meat carcinogen 2-amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) were identified in the livers of rats exposed to MeIQx, by the CNL-MS3 scan mode. 4-biphenylamine 43-58 amine oxidase copper containing 1 Homo sapiens 117-120 17671226-1 2007 Cigarette smoking is a major risk factor for bladder cancer and a prominent point source of 4-aminobiphenyl (4-ABP), a recognized human bladder carcinogen. 4-biphenylamine 92-107 amine oxidase copper containing 1 Homo sapiens 111-114 17477866-1 2007 BACKGROUND: The aromatic amine 4-aminobiphenyl (4-ABP) is an environmental and occupational contaminant known to be a major etiological agent of human bladder cancer. 4-biphenylamine 31-46 sex hormone binding globulin Homo sapiens 50-53 16988941-3 2006 Although it is generally accepted that ABP is metabolically activated via N-hydroxylation by CYP1A2 in human liver, previous studies using Cyp1a2-null mice indicated the involvement of other enzyme(s). 4-biphenylamine 39-42 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 93-99 16988941-3 2006 Although it is generally accepted that ABP is metabolically activated via N-hydroxylation by CYP1A2 in human liver, previous studies using Cyp1a2-null mice indicated the involvement of other enzyme(s). 4-biphenylamine 39-42 cytochrome P450 family 1 subfamily A member 2 Homo sapiens 139-145 16112689-1 2006 4-Aminobiphenyl (4-ABP) and its analogue, 2-aminobiphenyl (2-ABP), were examined for their ability to induce oxidative DNA damage in Hep G2 cells. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 19-22 16112689-1 2006 4-Aminobiphenyl (4-ABP) and its analogue, 2-aminobiphenyl (2-ABP), were examined for their ability to induce oxidative DNA damage in Hep G2 cells. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 61-64 16314341-4 2006 Groups of five or six neonatal male mice were treated with 0.3 micromol 4-aminobiphenyl (4-ABP) or the vehicle control, dimethylsulfoxide. 4-biphenylamine 72-87 amine oxidase, copper-containing 1 Mus musculus 91-94 16030125-2 2005 In this study, we developed and applied an assay using the luciferase (luc) reporter gene in a host-cell reactivation assay to measure DNA repair capacity for DNA damage induced by 4-aminobiphenyl (4-ABP), a well-studied aromatic amine and a known bladder carcinogen. 4-biphenylamine 181-196 amine oxidase copper containing 1 Homo sapiens 200-203 15746073-5 2005 Upon exposure to the carcinogen 4-aminobiphenyl (4-ABP), the untransformed HUC-PC undergoes malignant transformation whereas the transformed MC-T11 progresses from noninvasive to invasive tumor. 4-biphenylamine 32-47 sex hormone binding globulin Homo sapiens 51-54 15248958-1 2004 The fluorescence quenching of 4-aminodiphenyl (4ADP) with chloromethanes (CH2Cl2, CHCl3 and CCl4) have been studied in solvents of different polarity and viscosity. 4-biphenylamine 30-45 C-C motif chemokine ligand 4 Homo sapiens 92-96 15248958-1 2004 The fluorescence quenching of 4-aminodiphenyl (4ADP) with chloromethanes (CH2Cl2, CHCl3 and CCl4) have been studied in solvents of different polarity and viscosity. 4-biphenylamine 47-51 C-C motif chemokine ligand 4 Homo sapiens 92-96 19248797-3 2009 Arylamine N-acetyltransferases (NAT) are conjugating XMEs that play a key role in the biotransformation of aromatic amine pollutants such as the tobacco-smoke carcinogens 4-aminobiphenyl (4-ABP) and beta-naphthylamine (beta-NA). 4-biphenylamine 171-186 auxin-binding protein T92 Nicotiana tabacum 190-193 18989657-3 2008 In the present study, we analysed possible interactions between the aromatic amines 4-aminobiphenyl (4-ABP) as well as 2-naphthylamine (2-NA) and the polycyclic aromatic hydrocarbon benzo[a]pyrene (B[a]P). 4-biphenylamine 84-99 amine oxidase copper containing 1 Homo sapiens 103-106 17080401-1 2006 4-Aminobiphenyl (4-ABP) is an arylamine that has long been associated with human and animal urinary bladder cancer. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 19-22 16405939-2 2006 Hemoglobin (Hb) adducts of 3-aminobiphenyl (3-ABP) and 4-aminobiphenyl (4-ABP) have been used as biomarkers of exposure to aromatic amines from cigarette smoke. 4-biphenylamine 55-70 amine oxidase copper containing 1 Homo sapiens 74-77 12928348-9 2003 Overall, Cyp1a2(+/+) mice had fewer DNA adducts 24 hours after ABP treatment than similarly treated Cyp1a2(-/-) mice. 4-biphenylamine 63-66 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 9-15 12928348-12 2003 After 2 hours of ABP treatment, hepatic thiol levels underwent statistically significant declines of severalfold in Cyp1a2(+/+) and Cyp1a2(-/-) males and in Cyp1a2(-/-) females. 4-biphenylamine 17-20 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 116-122 12928348-2 2003 Results of in vitro and cell culture studies have suggested that cytochrome P450 1A2 (CYP1A2) is the major metabolic activator of ABP. 4-biphenylamine 130-133 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 65-84 12928348-12 2003 After 2 hours of ABP treatment, hepatic thiol levels underwent statistically significant declines of severalfold in Cyp1a2(+/+) and Cyp1a2(-/-) males and in Cyp1a2(-/-) females. 4-biphenylamine 17-20 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 132-138 12928348-2 2003 Results of in vitro and cell culture studies have suggested that cytochrome P450 1A2 (CYP1A2) is the major metabolic activator of ABP. 4-biphenylamine 130-133 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 86-92 12928348-12 2003 After 2 hours of ABP treatment, hepatic thiol levels underwent statistically significant declines of severalfold in Cyp1a2(+/+) and Cyp1a2(-/-) males and in Cyp1a2(-/-) females. 4-biphenylamine 17-20 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 132-138 12618593-7 2003 NAT1 and NAT2 in liver and prostate catalysed -acetylation of the arylamines above and O-acetylation of N-hydroxy derivatives of 2-aminofluorene, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 4-biphenylamine 146-161 N-acetyltransferase 1 Homo sapiens 0-4 12618593-7 2003 NAT1 and NAT2 in liver and prostate catalysed -acetylation of the arylamines above and O-acetylation of N-hydroxy derivatives of 2-aminofluorene, 4-aminobiphenyl and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine. 4-biphenylamine 146-161 N-acetyltransferase 2 Homo sapiens 9-13 12638701-1 2003 This article presents our work with HPLC-UV to determine hemoglobin adducts produced by adduction reaction among 4-aminobiphenyl (4-ABP) or/and 2-naphthylamine (2-NA) and human hemoglobin in vitro. 4-biphenylamine 113-128 amine oxidase copper containing 1 Homo sapiens 132-135 12009904-1 2002 4-Aminobiphenyl (4-ABP) is a major etiological agent for human bladder cancer. 4-biphenylamine 0-15 sex hormone binding globulin Homo sapiens 19-22 12376482-1 2002 4-aminobiphenyl (4-ABP) is a major etiological agent of human bladder cancer, and its metabolites are able to form DNA adducts that may induce mutation and initiate bladder carcinogenesis. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 19-22 11275476-2 2001 We investigated the ability of an aromatic amine, 4-aminobiphenyl (4-ABP) and its N-hydroxy metabolite (4-ABP(NHOH)) to cause oxidative DNA damage, using (32)P-labeled human DNA fragments from the p53 tumor suppressor gene and the c-Ha-ras-1 protooncogene. 4-biphenylamine 50-65 amine oxidase copper containing 1 Homo sapiens 69-72 12030840-5 2002 We therefore examined the role of CYP1A2 in causing methemoglobinemia in ABP-treated Cyp1a2(-/-) knockout mice. 4-biphenylamine 73-76 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 85-91 12030840-6 2002 Application of ABP (100 micromol/kg body wt) to the skin resulted in a marked depletion in the levels of the hepatic thiols (reduced glutathione and cysteine) after 2 h, which rebounded to basal levels 24 h later, and we found no differences between the Cyp1a2(-/-) and wild-type Cyp1a2(+/+) animals. 4-biphenylamine 15-18 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 254-260 12030840-6 2002 Application of ABP (100 micromol/kg body wt) to the skin resulted in a marked depletion in the levels of the hepatic thiols (reduced glutathione and cysteine) after 2 h, which rebounded to basal levels 24 h later, and we found no differences between the Cyp1a2(-/-) and wild-type Cyp1a2(+/+) animals. 4-biphenylamine 15-18 cytochrome P450, family 1, subfamily a, polypeptide 2 Mus musculus 280-286 12016161-1 2002 Exposure to 4-aminobiphenyl (4-ABP) is an important determinant of urinary bladder cancer in humans. 4-biphenylamine 12-27 amine oxidase copper containing 1 Homo sapiens 31-34 11697451-3 2001 Blood samples were routinely taken and analysed for aniline, 4-aminodiphenyl (4-ADP) and benzidine adducts of haemoglobin (Hb) and human serum albumin (HSA). 4-biphenylamine 78-83 albumin Homo sapiens 137-150 11563605-1 2001 OBJECTIVE: The influence of area of residence on haemoglobin (Hb) adducts of 4-aminobiphenyl (4-ABP), o-, m-, p-toluidine and o-anisidine was investigated in children from three different-sized Bavarian cities - Munich, Augsburg and Eichstatt, with 1,300,000, 250,000 and 13,000 inhabitants, respectively--and was compared with that of exposure to environmental tobacco smoke (ETS). 4-biphenylamine 77-92 amine oxidase copper containing 1 Homo sapiens 96-99 11355849-9 2001 In comparison, activities for the commonly used UGT substrates, 4-nitrophenol, 4-aminobiphenyl, and amitriptyline were 18.80, 3.23, and 0.23 nmol/min/mg protein, respectively. 4-biphenylamine 79-95 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 48-51 10915744-3 2000 Eight- and 6-fold increases in nuclear transcription factor kappaB (NF-kappaB), and 5- and 10-fold increases in activated protein (AP-1) transcription factor were observed with 24 hours AFB and BP treatments, respectively, whereas 4-ABP treatment resulted in an approximately 4-fold induction of both NF-kappaB and AP-1. 4-biphenylamine 231-236 nuclear factor kappa B subunit 1 Homo sapiens 301-310 10915744-4 2000 Moreover, 4-ABP gave the strongest NF-kappaB activation in 6 hours of treatment. 4-biphenylamine 10-15 nuclear factor kappa B subunit 1 Homo sapiens 35-44 10882891-1 2000 Tobacco smoke constituents, 4-aminobiphenyl (4-ABP) and polycyclic aromatic hydrocarbons (PAH) possess carcinogenic properties as their reactive metabolites form DNA adducts. 4-biphenylamine 28-43 auxin-binding protein T92 Nicotiana tabacum 47-50 10357788-1 1999 In this study, we developed a quantitative isotope dilution method for analysis of N-(deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-4-ABP), the principal nucleoside adduct derived from enzymatic hydrolysis of 4-aminobiphenyl (4-ABP)-modified DNA. 4-biphenylamine 107-122 amine oxidase, copper-containing 1 Mus musculus 132-135 23885982-6 2000 4-ABP-DNA adducts were higher in tissues with elevated levels of CYP1A1/2 (p = 0.02). 4-biphenylamine 0-5 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 65-73 23885982-10 2000 In HCC cases, 4-ABP-DNA adducts were higher in subjects with higher levels of CYP1A1/2, stratified by tissue type, but these differences were not significant. 4-biphenylamine 14-19 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 78-84 10650812-1 1999 BACKGROUND: Activated intermediates of 4-aminobiphenyl (4-ABP) are able to covalently interact with DNA to form adducts. 4-biphenylamine 39-54 amine oxidase copper containing 1 Homo sapiens 58-61 10469630-1 1999 4-Aminobiphenyl (4-ABP), a potent carcinogen in rodents (liver cancer) and human (bladder cancer), is found as an environmental contaminant and in tobacco smoke. 4-biphenylamine 0-15 amine oxidase, copper-containing 1 Mus musculus 19-22 10959793-1 2000 High levels of haemoglobin (Hb) adducts from 4-aminobiphenyl (4-ABP), a proven human carcinogen, have been reported in untreated animals from different laboratories fed various commercial standard diets. 4-biphenylamine 45-60 amine oxidase copper containing 1 Homo sapiens 64-67 10357788-1 1999 In this study, we developed a quantitative isotope dilution method for analysis of N-(deoxyguanosine-8-yl)-4-aminobiphenyl (dG-C8-4-ABP), the principal nucleoside adduct derived from enzymatic hydrolysis of 4-aminobiphenyl (4-ABP)-modified DNA. 4-biphenylamine 107-122 amine oxidase, copper-containing 1 Mus musculus 226-229 9194416-1 1997 While current human exposure to 4-aminobiphenyl (4-ABP) is mainly through inhalation, historically, occupational exposure occurred most often through the skin. 4-biphenylamine 32-47 amine oxidase copper containing 1 Homo sapiens 51-54 9616184-4 1998 We show that human UGT1A3, transiently expressed in human embryonic kidney 293 cells, also catalyzes the N-glucuronidation of primary, secondary, and tertiary amine substrates, such as 4-aminobiphenyl, diphenylamine, and cyproheptadine. 4-biphenylamine 185-201 UDP glucuronosyltransferase family 1 member A3 Homo sapiens 19-25 10064866-7 1999 Of the metabolic genotypes examined, the presence of ABP-DNA adducts was strongly associated with the putative slow NAT1*4/*4 genotype, suggesting a role for this pathway in ABP detoxification. 4-biphenylamine 53-56 N-acetyltransferase 1 Homo sapiens 116-120 9498288-1 1998 4-Aminobiphenyl (4-ABP)-DNA adducts and p53 overexpression were evaluated in laryngeal biopsies from 38 patients by immunohistochemical methods. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 19-22 9138663-2 1997 A monoclonal antibody that recognizes 4-aminobiphenyl (4-ABP)-DNA adducts was initially tested on liver tissues of BALB/c mice treated with 4-ABP, then applied to the detection of adducts in oral mucosa and exfoliated urothelial cells of smokers and nonsmokers. 4-biphenylamine 38-53 amine oxidase, copper-containing 1 Mus musculus 57-60 9138663-2 1997 A monoclonal antibody that recognizes 4-aminobiphenyl (4-ABP)-DNA adducts was initially tested on liver tissues of BALB/c mice treated with 4-ABP, then applied to the detection of adducts in oral mucosa and exfoliated urothelial cells of smokers and nonsmokers. 4-biphenylamine 38-53 amine oxidase, copper-containing 1 Mus musculus 142-145 7628292-5 1995 Carcinogenic primary amines (beta-naphthylamine, benzidine, and 4-aminobiphenyl) also reacted with the expressed UGT1.4 protein at rates approximately 10-fold higher than the rates for quaternary ammonium glucuronide formation. 4-biphenylamine 64-79 UDP glucuronosyltransferase family 1 member A4 Homo sapiens 113-119 8665480-1 1996 The tumorigenicity of 4-aminobiphenyl (4-ABP) and 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP) were studied in combination with caloric restriction in the male neonatal CD1 mouse bioassay. 4-biphenylamine 22-37 amine oxidase, copper-containing 1 Mus musculus 41-44 8640937-1 1996 An immunoperoxidase method, using a monoclonal antibody which recognizes 4-aminobiphenyl (4-ABP)-DNA adducts, was developed for the detection and quantitation of DNA damage in bladder tissue and applied to stored paraffin blocks of transurethral resection specimens of 46 patients with T1 bladder cancer. 4-biphenylamine 73-88 amine oxidase copper containing 1 Homo sapiens 92-95 8603464-1 1995 Recent studies have demonstrated the presence of DNA adducts from 4-aminobiphenyl (4-ABP) in the bladder cells of humans; however, the correlation between the concentration of these adducts and the tumorigenic response is not clear. 4-biphenylamine 66-81 amine oxidase, copper-containing 1 Mus musculus 85-88 8634658-1 1995 Cigarette smoking is the major cause of bladder cancer in men in the United States, and the arylamines contained in cigarettes smoke, including 4-amino-biphenyl (4-ABP), are believed to play an important role in the induction of bladder cancer among smokers. 4-biphenylamine 144-160 amine oxidase copper containing 1 Homo sapiens 164-167 9020311-1 1997 Benzidine and 4-aminobiphenyl (4-ABP) are promutagenic bicyclic aromatic amines that are activated into frameshift and base pair substitution mutagens by plant systems. 4-biphenylamine 14-29 auxin-binding protein T92 Nicotiana tabacum 33-36 7548758-1 1995 Two monoclonal antisera, 4C11 and 3C8, recognizing 4-aminobiphenyl (4-ABP)--DNA adducts were developed and characterized by competitive enzyme-linked immunosorbent assay (ELISA). 4-biphenylamine 51-66 amine oxidase, copper-containing 1 Mus musculus 70-73 8118934-1 1994 Carcinogenic aromatic amines such as 4-aminobiphenyl (4-ABP) are extensively metabolized by both oxidative and conjugation reactions. 4-biphenylamine 37-52 amine oxidase, copper containing 1 Rattus norvegicus 56-59 7923441-9 1994 Since haptoglobin functions to bind with free hemoglobin and facilitates its elimination from the blood stream, these results can be rationalized as a consequence of 4-ABP binding to hemoglobin in the erythrocyte, resulting in cell death and hemolysis. 4-biphenylamine 166-171 haptoglobin Canis lupus familiaris 6-17 7923441-10 1994 The 4-ABP modified hemoglobin then binds to haptoglobin and this tertiary complex is purged from the blood stream, resulting in the disappearance of free haptoglobin. 4-biphenylamine 4-9 haptoglobin Canis lupus familiaris 44-55 7923441-10 1994 The 4-ABP modified hemoglobin then binds to haptoglobin and this tertiary complex is purged from the blood stream, resulting in the disappearance of free haptoglobin. 4-biphenylamine 4-9 haptoglobin Canis lupus familiaris 154-165 7889831-2 1994 We have established a method for quantitation of 4-aminobiphenyl (4-ABP)-DNA adducts by alkaline hydrolysis and gas chromatography with negative ion chemical ionization mass spectrometry (GC-NICI-MS). 4-biphenylamine 49-64 amine oxidase copper containing 1 Homo sapiens 68-71 8118381-5 1994 NAT and OAT activities were determined using 4-aminobiphenyl (ABP) and [3H]N-hydroxy-4-aminobiphenyl (N-OH-ABP) as substrates, respectively. 4-biphenylamine 45-60 bromodomain containing 2 Homo sapiens 0-3 8118381-5 1994 NAT and OAT activities were determined using 4-aminobiphenyl (ABP) and [3H]N-hydroxy-4-aminobiphenyl (N-OH-ABP) as substrates, respectively. 4-biphenylamine 62-65 bromodomain containing 2 Homo sapiens 0-3 8319620-1 1993 Hemoglobin adducts of the common metabolite of the tobacco-specific nitrosamine (TSNA) 4-hydroxy-1-(3-pyridyl)-1-butanone (HPB) and of 4-aminobiphenyl (4-ABP) were quantified in blood samples from smokers and nonsmokers to test their suitability for biomonitoring tobacco smoke exposure. 4-biphenylamine 135-150 auxin-binding protein T92 Nicotiana tabacum 154-157 8445675-1 1993 BACKGROUND: A potent bladder carcinogen for workers in the dye industry, 4-aminobiphenyl (4-ABP), is present in environmental tobacco smoke and has been shown to bond covalently with hemoglobin. 4-biphenylamine 73-88 auxin-binding protein T92 Nicotiana tabacum 92-95 1362943-5 1992 A polyclonal antibody preparation raised in sheep against rabbit liver p-nitrophenol UGT was found to inhibit tripelennamine glucuronidation in solubilized human liver microsomes, but had no effect on p-nitrophenol, 4-methylumbelliferone, 4-aminobiphenyl, estriol, morphine, or naloxone glucuronidation. 4-biphenylamine 239-254 UDP glucuronosyltransferase family 1 member A complex locus Homo sapiens 85-88 1756515-1 1991 We determined the hemoglobin adduct levels of one aromatic amine of cigarette smoke, 4-aminobiphenyl (4-ABP), in smoking controls and in patients with transitional cell bladder carcinoma. 4-biphenylamine 85-100 amine oxidase copper containing 1 Homo sapiens 104-107 1423849-1 1992 4-Aminobiphenyl (4-ABP) is a human and mouse bladder carcinogen. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 19-22 34783865-6 2022 Compound 10 inhibited N-acetylation of the arylamine carcinogen 4-aminobiphenyl (ABP) both in vitro and in DNA repair-deficient Chinese hamster ovary (CHO) cells in situ stably expressing human NAT1 and CYP1A1. 4-biphenylamine 64-79 N-acetyltransferase 1 Homo sapiens 194-198 34474361-1 2022 4-Aminobiphenyl (4-ABP) is a human bladder cancer carcinogen found in the manufacture of azo dyes and the composition of cigarette smoke in the environment. 4-biphenylamine 0-15 amine oxidase copper containing 1 Homo sapiens 19-22 34783865-6 2022 Compound 10 inhibited N-acetylation of the arylamine carcinogen 4-aminobiphenyl (ABP) both in vitro and in DNA repair-deficient Chinese hamster ovary (CHO) cells in situ stably expressing human NAT1 and CYP1A1. 4-biphenylamine 64-79 cytochrome P450 family 1 subfamily A member 1 Homo sapiens 203-209 35273499-1 2022 Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). 4-biphenylamine 106-121 N-acetyltransferase 1 Homo sapiens 6-37 35273499-1 2022 Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). 4-biphenylamine 106-121 N-acetyltransferase 1 Homo sapiens 39-43 35273499-1 2022 Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). 4-biphenylamine 123-126 N-acetyltransferase 1 Homo sapiens 6-37 35273499-1 2022 Human arylamine N-acetyltransferase 1 (NAT1) catalyzes the N-acetylation of arylamine carcinogens such as 4-aminobiphenyl (ABP), and following N-hydroxylation, the O-acetylation of N-hydroxy-arylamine carcinogens such as N-hydroxy-ABP (N-OH-ABP). 4-biphenylamine 123-126 N-acetyltransferase 1 Homo sapiens 39-43 35273499-3 2022 The effects of individual single nucleotide polymorphisms (SNPs) in the NAT1 coding exon on Michaelis-Menten kinetic constants was assessed for ABP N-acetyltransferase and N-OH-ABP O-acetyltransferase activity following transfection of human NAT1 into COS-1 cells (SV40-transformed African green monkey kidney cells). 4-biphenylamine 144-147 N-acetyltransferase 1 Homo sapiens 72-76 35273499-4 2022 NAT1 coding region SNPs 97C > T (rs56318881) (R33stop), 190C > T (rs56379106) (R64W), 559C > T (rs5030839) (R187stop) and 752A > T (rs56172717) (D251V) reduced ABP N- acetyltransferase and N-OH-ABP O-acetyltransferase activity below detection. 4-biphenylamine 160-163 N-acetyltransferase 1 Homo sapiens 0-4