PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32897441-10	2021	Presence of nodal metastases (HR 3.87; 95%CI 1.17-12.8; p = 0.027) and positive margins (HR 12.3; 95%CI 3.54-42.9; p < 0.001) also independently predicted poor DSS.	dss	160-163	nodal growth differentiation factor	Homo sapiens	12-17
34020310-5	2021	SETD2 expression became decreased in IBD patients and dextran sodium sulfate (DSS)-induced colitic mice.	dss	78-81	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	0-5
33845143-17	2021	Subsequent animal-based in vivo experiments revealed that JQP ameliorated symptoms and histological changes in DSS colitis by significantly impairing DSS"s ability to induce high expression levels of NF-kappaB/p65, IL-1beta, IL-6, and TNF-alpha.	dss	150-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	200-213
33845143-17	2021	Subsequent animal-based in vivo experiments revealed that JQP ameliorated symptoms and histological changes in DSS colitis by significantly impairing DSS"s ability to induce high expression levels of NF-kappaB/p65, IL-1beta, IL-6, and TNF-alpha.	dss	150-153	interleukin 1 alpha	Mus musculus	215-223
33845143-17	2021	Subsequent animal-based in vivo experiments revealed that JQP ameliorated symptoms and histological changes in DSS colitis by significantly impairing DSS"s ability to induce high expression levels of NF-kappaB/p65, IL-1beta, IL-6, and TNF-alpha.	dss	150-153	interleukin 6	Mus musculus	225-229
33845143-17	2021	Subsequent animal-based in vivo experiments revealed that JQP ameliorated symptoms and histological changes in DSS colitis by significantly impairing DSS"s ability to induce high expression levels of NF-kappaB/p65, IL-1beta, IL-6, and TNF-alpha.	dss	150-153	tumor necrosis factor	Mus musculus	235-244
33845143-18	2021	JQP also reduced the the levels of COX-2, CCL2, CXCL2, HIF-1alpha, MMP3 and MMP9 and regulated the Th17/Treg cell balance in DSS-induced mice.	dss	125-128	matrix metallopeptidase 9	Mus musculus	76-80
33722746-3	2021	We show that Spink7 (serine peptidase inhibitor, kazal type 7), the ortholog of human SPINK7, is significantly upregulated in dextran sodium sulfate (DSS)-induced murine colitis model.	dss	150-153	serine peptidase inhibitor Kazal type 7	Homo sapiens	13-19
33722746-3	2021	We show that Spink7 (serine peptidase inhibitor, kazal type 7), the ortholog of human SPINK7, is significantly upregulated in dextran sodium sulfate (DSS)-induced murine colitis model.	dss	150-153	serine peptidase inhibitor Kazal type 7	Homo sapiens	86-92
33934543-7	2021	The Kaplan-Meier survival curve confirmed that higher BAI1 expression was significantly associated with poor DSS (p = 0.034) in the nonsmoking group.	dss	109-112	adhesion G protein-coupled receptor B1	Homo sapiens	54-58
33705946-6	2021	The in vivo experiments showed that gma-miR159a and soybean RNA (total RNA extracted from soybean) significantly reduced tumor growth in AOM/DSS-induced colon cancer mice by gavage.	dss	141-144	MIR159A	Glycine max	36-47
33029672-11	2021	Moreover, the expression of beta-catenin increased in the colonic tissues during the recovery phase of DSS-induced colitis but decreased during the inflammation phase of DSS-induced colitis.	dss	103-106	catenin (cadherin associated protein), beta 1	Mus musculus	28-40
33029672-11	2021	Moreover, the expression of beta-catenin increased in the colonic tissues during the recovery phase of DSS-induced colitis but decreased during the inflammation phase of DSS-induced colitis.	dss	170-173	catenin (cadherin associated protein), beta 1	Mus musculus	28-40
34014550-9	2021	Elevated NOP58 expression had poor disease-specific survival (DSS; P < 0.001), progression-free interval (P = 0.006), and overall survival (OS; P < 0.001).	dss	62-65	NOP58 ribonucleoprotein	Homo sapiens	9-14
34043102-7	2021	Furthermore, in multivariate analysis, high FRMD3 immunoexpression remained independently predictive of inferior DSS (p = 0.002), LRFS (p = 0.005), and MeFS (p = 0.015).	dss	113-116	FERM domain containing 3	Homo sapiens	44-49
34017102-8	2021	Moreover, Trim26 deficiency attenuates the severity of dextran sodium sulfate (DSS)-induced colitis.	dss	79-82	tripartite motif-containing 26	Mus musculus	10-16
34043319-3	2021	First, starch acetoacetate (SAA) with different degrees of substitution (DSs) was synthesized by transesterification.	dss	73-76	serum amyloid A1 cluster	Homo sapiens	28-31
34043319-5	2021	Notably, SAA with different DSs exhibited various glass transition temperatures (109-140  C), and SAA with high DS (>0.84) was insoluble even after boiling in water for 1 h. Also, the maximum fracture strength of SAA film up to 15.5 MPa and a maximum elongation at break up to 30% were reached .	dss	28-31	serum amyloid A1 cluster	Homo sapiens	9-12
33962939-2	2021	We show that dendritic cell (DC)-specific deficiency of casitas B-lineage lymphoma (c-Cbl) renders mice susceptible to dextran sodium sulfate (DSS)-induced colitis.	dss	143-146	Casitas B-lineage lymphoma	Mus musculus	56-89
33991018-6	2021	3% dextran sodium sulfate (DSS) induced colitis murine model injection with SETD8 inhibitor was used in our study to investigate whether SETD8 inhibition can affect the progress of IBD.	dss	27-30	lysine methyltransferase 5A	Mus musculus	76-81
33991018-14	2021	Finally, SETD8 pharmacological inhibitor (UNC0379) aggravated the disease progression in DSS-induced murine colitis.	dss	89-92	lysine methyltransferase 5A	Mus musculus	9-14
34026335-8	2021	After AOM/DSS induction, tumor burden and volume were increased, characterized by enhanced proliferation and activation of Wnt/beta-catenin signaling pathway.	dss	10-13	catenin (cadherin associated protein), beta 1	Mus musculus	127-139
33984358-3	2021	In this study we found that the expression of miR-145 was downregulated in the colonic tissues of rats with Dextran sodium sulfate (DSS)-induced UC.	dss	132-135	microRNA 145	Rattus norvegicus	46-53
33962939-4	2021	Thus, c-Cbl deficiency in DCs promotes alpha-mannan-induced activation of RelB, which suppresses p65-mediated transcription of an anti-inflammatory cytokine gene, il10, thereby aggravating DSS-induced colitis.	dss	189-192	Casitas B-lineage lymphoma	Mus musculus	6-11
33962939-4	2021	Thus, c-Cbl deficiency in DCs promotes alpha-mannan-induced activation of RelB, which suppresses p65-mediated transcription of an anti-inflammatory cytokine gene, il10, thereby aggravating DSS-induced colitis.	dss	189-192	avian reticuloendotheliosis viral (v-rel) oncogene related B	Mus musculus	74-78
32160108-4	2021	Interestingly, we found that nrbf2-/- mice and macrophages displayed impaired apoptotic cell clearance capability, while adoptive transfer of nrbf2+/+ macrophages to nrbf2-/- mice alleviated DSS-induced colitis lesions.	dss	191-194	nuclear receptor binding factor 2	Mus musculus	142-147
34012911-8	2021	We demonstrated that SMAD4 is positively correlated with decreased disease specific survival (DSS) in RCC patients and clear cell RCC (ccRCC) subtype and associates with poor DSS in patients with RCC, especially in ccRCC as the most metastatic RCC subtype.	dss	94-97	SMAD family member 4	Homo sapiens	21-26
32160108-4	2021	Interestingly, we found that nrbf2-/- mice and macrophages displayed impaired apoptotic cell clearance capability, while adoptive transfer of nrbf2+/+ macrophages to nrbf2-/- mice alleviated DSS-induced colitis lesions.	dss	191-194	nuclear receptor binding factor 2	Mus musculus	142-147
33727168-7	2021	In multivariate analysis, worse DSS was correlated with budding score Bd2/Bd3 (hazard ratio [HR] 2.6687, 95% confidence interval [CI] 1.585-5.217, P=0.001) and with nodal disease (HR 2.876, 95% CI 1.585-5.217, P=0.001).	dss	32-35	defensin beta 103B	Homo sapiens	74-77
33727168-7	2021	In multivariate analysis, worse DSS was correlated with budding score Bd2/Bd3 (hazard ratio [HR] 2.6687, 95% confidence interval [CI] 1.585-5.217, P=0.001) and with nodal disease (HR 2.876, 95% CI 1.585-5.217, P=0.001).	dss	32-35	defensin beta 4A	Homo sapiens	70-73
33920268-7	2021	The knockout of Usp22 increased inflammation-associated symptoms after DSS treatment locally and systemically.	dss	71-74	ubiquitin specific peptidase 22	Homo sapiens	16-21
33932348-9	2021	RESULTS: Compared with wild-type counterparts, TRAIL-/- mice developed more severe colitis after DSS treatment.	dss	97-100	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	47-52
33901495-9	2021	Although MondoA-deficient Tregs were less immune suppressive and selectively promoted Th1 responses in a subcutaneous MC38 tumor model, Treg-specific MondoA knockout mice were more susceptible to AOM-DSS-induced colorectal cancer.	dss	200-203	MLX interacting protein	Homo sapiens	150-156
33877484-0	2021	An immuno-blocking agent targeting IL-1beta and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice.	dss	77-80	interleukin 1 alpha	Mus musculus	35-43
33877484-0	2021	An immuno-blocking agent targeting IL-1beta and IL-17A reduces the lesion of DSS-induced ulcerative colitis in mice.	dss	77-80	interleukin 17A	Mus musculus	48-54
33877484-9	2021	We conclude that the blocking of IL-1beta and IL-17A can inhibit DSS-induced ulcerative colitis and FL-BsAb1/17 may have potential to become a new dual-target candidate for colitis treatment.	dss	65-68	interleukin 1 alpha	Mus musculus	33-41
33877484-9	2021	We conclude that the blocking of IL-1beta and IL-17A can inhibit DSS-induced ulcerative colitis and FL-BsAb1/17 may have potential to become a new dual-target candidate for colitis treatment.	dss	65-68	interleukin 17A	Mus musculus	46-52
33986741-9	2021	Moreover, LST1-deficient mice show significant level of resistance to dextran sodium sulphate (DSS) induced acute colitis, a model of inflammatory bowel disease.	dss	95-98	leukocyte specific transcript 1	Mus musculus	10-14
33836047-6	2021	RESULTS: DSS administration increased colonic permeability through modulation of TJ proteins and also increased MMP-12 expression in the colonic mucosa of WT mice.	dss	9-12	matrix metallopeptidase 12	Mus musculus	112-118
33832153-8	2021	However, Further analysis revealed that high AKR1B10 expression indicated poor OS in oral squamous cell carcinomas (OSCC) (HR: 2.92, 95% CI: 1.86-4.58) and favorable DSS in hepatocellular carcinoma (HCC) (HR: 0.71, 95% CI: 0.52-0.97).	dss	166-169	aldo-keto reductase family 1 member B10	Homo sapiens	45-52
33830241-4	2021	OBJECTIVES: The aim was to test the hypothesis that in a DSS model, rats select a protein-to-energy (PE) ratio to maintain the protein-to-carbohydrate (PC) ratio constant and that fibroblast growth factor 21 (FGF21) is involved in this response.	dss	57-60	prolyl endopeptidase	Rattus norvegicus	101-103
33830241-7	2021	The second was to test whether the PE ratio was defended with a modified DSS model.	dss	73-76	prolyl endopeptidase	Rattus norvegicus	35-37
33917884-4	2021	An association between dyslipidemia, LDL oxidation, CD36 expression, ROS generation, thioredoxin-interacting protein (TXNIP) upregulation, and NLRP3 inflammasome activation was demonstrated by DSS exposure in HFD-fed rats.	dss	193-196	thioredoxin interacting protein	Rattus norvegicus	118-123
33917884-4	2021	An association between dyslipidemia, LDL oxidation, CD36 expression, ROS generation, thioredoxin-interacting protein (TXNIP) upregulation, and NLRP3 inflammasome activation was demonstrated by DSS exposure in HFD-fed rats.	dss	193-196	NLR family, pyrin domain containing 3	Rattus norvegicus	143-148
33917884-5	2021	We demonstrated that rosuvastatin/Lactobacillus significantly suppressed the DSS/HFD-induced increase in colon weight/length ratio, DAI, MDI, and myeloperoxidase, as well as corrected dysbiosis and improved histological characteristics.	dss	77-80	myeloperoxidase	Rattus norvegicus	146-161
33836047-7	2021	The acute as well as chronic DSS-induced increase in colonic TJ permeability and the severity of DSS colitis was found to be markedly attenuated in MMP-12 -/- mice.	dss	29-32	matrix metallopeptidase 12	Mus musculus	148-154
33836047-7	2021	The acute as well as chronic DSS-induced increase in colonic TJ permeability and the severity of DSS colitis was found to be markedly attenuated in MMP-12 -/- mice.	dss	97-100	matrix metallopeptidase 12	Mus musculus	148-154
33861936-0	2021	Shinan Sea Salt Intake Ameliorates Colorectal Cancer in AOM/DSS with High Fat Diet-Induced C57BL/6N Mice.	dss	60-63	sepia	Mus musculus	7-10
33917356-6	2021	We also demonstrated, via univariable and multivariable analyses, that the low CLDN12 expression represents a significant prognostic factor for the DSS of cervical cancer patients (HR 3.412, p = 0.002 and HR 2.615, p = 0.029, respectively).	dss	148-151	claudin 12	Homo sapiens	79-85
33512049-11	2021	Similar improvements were seen in animals in the low dose DSS group, who received FUS only once daily for 12 days.	dss	58-61	Fus RNA binding protein	Rattus norvegicus	82-85
33512049-12	2021	Moreover, animals in the high dose DSS group receiving FUS twice daily maintained colon length (17.7 +- 2.5 cm), while rats drinking DSS without FUS exhibited marked damage and shortening of the colon (13.8 +- 0.6 cm) as expected.	dss	35-38	Fus RNA binding protein	Rattus norvegicus	55-58
33512049-13	2021	Inflammatory cytokines such as IL-1beta, IL-6, IL-17, TNF-alpha and IFN-gamma were reduced with DSS but coincided with control levels after FUS, which is plausibly due to a loss of colon crypt presence in the former and healthier crypt in the latter.	dss	96-99	interleukin 1 alpha	Rattus norvegicus	31-39
33512049-13	2021	Inflammatory cytokines such as IL-1beta, IL-6, IL-17, TNF-alpha and IFN-gamma were reduced with DSS but coincided with control levels after FUS, which is plausibly due to a loss of colon crypt presence in the former and healthier crypt in the latter.	dss	96-99	interleukin 6	Rattus norvegicus	41-45
33512049-13	2021	Inflammatory cytokines such as IL-1beta, IL-6, IL-17, TNF-alpha and IFN-gamma were reduced with DSS but coincided with control levels after FUS, which is plausibly due to a loss of colon crypt presence in the former and healthier crypt in the latter.	dss	96-99	interleukin 17A	Rattus norvegicus	47-52
33512049-13	2021	Inflammatory cytokines such as IL-1beta, IL-6, IL-17, TNF-alpha and IFN-gamma were reduced with DSS but coincided with control levels after FUS, which is plausibly due to a loss of colon crypt presence in the former and healthier crypt in the latter.	dss	96-99	tumor necrosis factor	Rattus norvegicus	54-63
33512049-13	2021	Inflammatory cytokines such as IL-1beta, IL-6, IL-17, TNF-alpha and IFN-gamma were reduced with DSS but coincided with control levels after FUS, which is plausibly due to a loss of colon crypt presence in the former and healthier crypt in the latter.	dss	96-99	interferon gamma	Rattus norvegicus	68-77
33512049-13	2021	Inflammatory cytokines such as IL-1beta, IL-6, IL-17, TNF-alpha and IFN-gamma were reduced with DSS but coincided with control levels after FUS, which is plausibly due to a loss of colon crypt presence in the former and healthier crypt in the latter.	dss	96-99	Fus RNA binding protein	Rattus norvegicus	140-143
33015735-0	2021	Luteolin Relieved DSS-Induced Colitis in Mice via HMGB1-TLR-NF-kappaB Signaling Pathway.	dss	18-21	high mobility group box 1	Mus musculus	50-55
33015735-0	2021	Luteolin Relieved DSS-Induced Colitis in Mice via HMGB1-TLR-NF-kappaB Signaling Pathway.	dss	18-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	60-69
33015735-15	2021	In conclusion, Lu significantly reduced and alleviated DSS-induced colitis in mice, and the mechanism was related to the regulation of intestinal HMGB1-TLR-NF-kappaB signaling pathway in mice.	dss	55-58	high mobility group box 1	Mus musculus	146-151
33015735-15	2021	In conclusion, Lu significantly reduced and alleviated DSS-induced colitis in mice, and the mechanism was related to the regulation of intestinal HMGB1-TLR-NF-kappaB signaling pathway in mice.	dss	55-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	156-165
33967779-2	2021	In a dextran sulfate sodium sulfate (DSS)-induced UC model in female mice, we found that the levels of cyclic guanosine monophosphate (cGMP) are reduced, while the expression of phosphodiesterase 9A (PDE9A) is highest among all phosphodiesterase (PDEs).	dss	37-40	phosphodiesterase 9A	Mus musculus	178-198
33967779-2	2021	In a dextran sulfate sodium sulfate (DSS)-induced UC model in female mice, we found that the levels of cyclic guanosine monophosphate (cGMP) are reduced, while the expression of phosphodiesterase 9A (PDE9A) is highest among all phosphodiesterase (PDEs).	dss	37-40	phosphodiesterase 9A	Mus musculus	200-205
33967779-2	2021	In a dextran sulfate sodium sulfate (DSS)-induced UC model in female mice, we found that the levels of cyclic guanosine monophosphate (cGMP) are reduced, while the expression of phosphodiesterase 9A (PDE9A) is highest among all phosphodiesterase (PDEs).	dss	37-40	phosphodiesterase 9A	Mus musculus	178-195
33967779-9	2021	PF treatment also reduced the DSS-induced inflammation by suppressing oxidative stress, NF-kappaB, STAT3, and inflammasome activation, by upregulating nuclear factor erythroid 2-related factor 2 (Nrf-2) and its downstream proteins via extracellular signal-regulated kinase (ERK) phosphorylation.	dss	30-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	88-97
33967779-9	2021	PF treatment also reduced the DSS-induced inflammation by suppressing oxidative stress, NF-kappaB, STAT3, and inflammasome activation, by upregulating nuclear factor erythroid 2-related factor 2 (Nrf-2) and its downstream proteins via extracellular signal-regulated kinase (ERK) phosphorylation.	dss	30-33	signal transducer and activator of transcription 3	Mus musculus	99-104
33861936-1	2021	The anticancer effects of Shinan (Shinan-South Korea) sea salts on azoxymethane (AOM)/dextran sodium sulfate (DSS) with high fat diet (HFD)-induced colon cancer and obesity in C57BL/6N mice were studied.	dss	110-113	sepia	Mus musculus	54-57
33796452-8	2021	While in the same stratum of Neo-Bioscore scores 2 and 3, the HER2-positive patients without trastuzumab therapy had much poorer DSS (P = 0.013 and P values < 0.01, respectively) as compared to HER2-positive patients with trastuzumab therapy and HER2-negative patients.	dss	129-132	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-66
33758177-5	2021	Our results demonstrated that the mice with macrophage-specific deletion of QKI induced with dextran sodium sulfate (DSS) are more susceptible to IBD development, exhibited a severe leaky gut barrier phenotype and higher intense oxidative stress, which are rescued by treating with butylated hydroxyanisole (BHA), an agonist of NRF2.	dss	117-120	quaking, KH domain containing RNA binding	Mus musculus	76-79
33758177-5	2021	Our results demonstrated that the mice with macrophage-specific deletion of QKI induced with dextran sodium sulfate (DSS) are more susceptible to IBD development, exhibited a severe leaky gut barrier phenotype and higher intense oxidative stress, which are rescued by treating with butylated hydroxyanisole (BHA), an agonist of NRF2.	dss	117-120	nuclear factor, erythroid derived 2, like 2	Mus musculus	328-332
33758177-7	2021	In addition, mice models of fecal microbiota transplant (FMT) and the co-culturing of mice epithelia cells with feces derived from the DSS-treated QKI-deficit mice revealed consistently aggravated colitis along with a severe oxidative stress; 16S sequencing analysis substantiated the altered compositions of commensal bacteria too.	dss	135-138	quaking, KH domain containing RNA binding	Mus musculus	147-150
33482271-3	2021	Carbon monoxide (CO) is an important gaseous molecule with versatile functions including anti-oxidation and anti-inflammation, and we previous reported the therapeutic potential of a nano-designed CO donor SMA/CORM2 in a dextran sulphate sodium (DSS) induced mouse colitis model.	dss	246-249	immunoglobulin mu binding protein 2	Mus musculus	206-209
33839039-7	2021	DSS rates in patients with positive and negative expression of SETD2 were 90.2% and 58.4%, respectively (P < .001).	dss	0-3	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	63-68
33839039-9	2021	In a multivariate Cox analysis, low SETD2 expression was an independent predictor of DSS (hazard ratio [HR], 1.690; 95% confidence interval [CI], 1.0582.700; P = .031) and OS (HR, 1.641; 95% CI, 1.039-2.593; P = .037).	dss	85-88	SET domain containing 2, histone lysine methyltransferase	Homo sapiens	36-41
32860065-3	2021	METHODS: We analyzed TRIM21 expression in tumor tissues from patients with colorectal cancer (CRC) and ulcerative colitis (UC)-associated cancer by immunohistochemistry and real-time polymerase chain reaction and established a CAC model in TRIM21-/- and wild type mice by azoxymethane (AOM) and dextran sodium sulfate (DSS).	dss	319-322	tripartite motif containing 21	Homo sapiens	21-27
32860065-5	2021	RESULTS: Expression of TRIM21 was found to be decreased in tumor tissues from patients with CRC and UC-associated cancer than that in controls, and TRIM21-/- deficiency promoted AOM/DSS-induced CAC, characterized by more weight loss and multiple, large colon tumors in TRIM21-/- mice.	dss	182-185	tripartite motif containing 21	Homo sapiens	148-154
32860065-5	2021	RESULTS: Expression of TRIM21 was found to be decreased in tumor tissues from patients with CRC and UC-associated cancer than that in controls, and TRIM21-/- deficiency promoted AOM/DSS-induced CAC, characterized by more weight loss and multiple, large colon tumors in TRIM21-/- mice.	dss	182-185	tripartite motif containing 21	Homo sapiens	148-154
33713543-5	2021	It was observed that the mucus layer was affected in P2ry6 knockout mice suffering from dextran sodium sulfate (DSS)-induced colitis.	dss	112-115	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	53-58
33713543-6	2021	P2ry6-/- mice were more sensitive to DSS-induced colitis, resulting in larger ulcers and increased disease activity index.	dss	37-40	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	0-5
33487121-10	2021	Conclusions In this large European population of DTC patients, when employing the histopathological criteria of the TNM system (8th edition), the optimal age cutoff to predict DSS is 50 years rather than the 55 years currently in use.	dss	176-179	teneurin transmembrane protein 1	Homo sapiens	116-119
33674694-5	2021	This DSS-induced colitis-associated lipid metabolic dysfunction was due to overall disruption of metabolic processes including fatty acid oxidation, lipogenesis, lipolysis, reverse cholesterol transport, bile acid synthesis, and white adipose tissue browning and brown adipose tissue thermogenesis, most of which are mediated by key regulators of energy homeostasis such as FGF21, adiponectin, and irisin, via SIRT1/PGC-1alpha- and LXRalpha-dependent pathways.	dss	5-8	fibroblast growth factor 21	Mus musculus	374-379
33674694-5	2021	This DSS-induced colitis-associated lipid metabolic dysfunction was due to overall disruption of metabolic processes including fatty acid oxidation, lipogenesis, lipolysis, reverse cholesterol transport, bile acid synthesis, and white adipose tissue browning and brown adipose tissue thermogenesis, most of which are mediated by key regulators of energy homeostasis such as FGF21, adiponectin, and irisin, via SIRT1/PGC-1alpha- and LXRalpha-dependent pathways.	dss	5-8	adiponectin, C1Q and collagen domain containing	Mus musculus	381-392
33674694-5	2021	This DSS-induced colitis-associated lipid metabolic dysfunction was due to overall disruption of metabolic processes including fatty acid oxidation, lipogenesis, lipolysis, reverse cholesterol transport, bile acid synthesis, and white adipose tissue browning and brown adipose tissue thermogenesis, most of which are mediated by key regulators of energy homeostasis such as FGF21, adiponectin, and irisin, via SIRT1/PGC-1alpha- and LXRalpha-dependent pathways.	dss	5-8	sirtuin 1	Mus musculus	410-415
33674694-5	2021	This DSS-induced colitis-associated lipid metabolic dysfunction was due to overall disruption of metabolic processes including fatty acid oxidation, lipogenesis, lipolysis, reverse cholesterol transport, bile acid synthesis, and white adipose tissue browning and brown adipose tissue thermogenesis, most of which are mediated by key regulators of energy homeostasis such as FGF21, adiponectin, and irisin, via SIRT1/PGC-1alpha- and LXRalpha-dependent pathways.	dss	5-8	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	416-426
33674694-5	2021	This DSS-induced colitis-associated lipid metabolic dysfunction was due to overall disruption of metabolic processes including fatty acid oxidation, lipogenesis, lipolysis, reverse cholesterol transport, bile acid synthesis, and white adipose tissue browning and brown adipose tissue thermogenesis, most of which are mediated by key regulators of energy homeostasis such as FGF21, adiponectin, and irisin, via SIRT1/PGC-1alpha- and LXRalpha-dependent pathways.	dss	5-8	nuclear receptor subfamily 1, group H, member 3	Mus musculus	432-440
33747901-8	2021	In p16 positivity patients, the 3-year DFS rates were 41% and 17% in patients with 0-2 and >=3 positive lymph nodes, respectively, the difference was significant; the 3-year DSS rates were 84 and 46% in patients with 0-2 and >=3 positive lymph nodes, the difference was significant.	dss	174-177	cyclin dependent kinase inhibitor 2A	Homo sapiens	3-6
33332758-3	2021	In this study, we attempted to determine the role of miR-223 in dextran sodium sulfate (DSS)-induced colitis and explore the involvement of the IL-6/STAT3 pathway in the development of intestinal mucosal inflammation.	dss	88-91	microRNA 223	Mus musculus	53-60
33332758-7	2021	RESULTS: miR-223 expression in the terminal ileum and colon was increased in the DSS group compared with the WT group.	dss	81-84	microRNA 223	Mus musculus	9-16
33332758-8	2021	Colitis symptoms were significantly alleviated in the DSS + A group and exacerbated in the DSS + AN group after administration of the miR-223 agomir and antagomir, respectively.	dss	91-94	microRNA 223	Mus musculus	134-141
33332758-9	2021	MPO, tumor necrosis factor-alpha, IL-6, and IL-17 were decreased and IL-10 was increased in the DSS + A group, but these changes were reversed in the DSS + AN group.	dss	96-99	interleukin 10	Mus musculus	69-74
33332758-11	2021	CONCLUSIONS: The upregulation of miR-223 by agomir administration alleviated colonic inflammation in a DSS-induced colitis model, which was likely mediated by inhibiting the production of pro-inflammatory cytokines via the IL-6/STAT3 signaling pathway.	dss	103-106	microRNA 223	Mus musculus	33-40
33332758-11	2021	CONCLUSIONS: The upregulation of miR-223 by agomir administration alleviated colonic inflammation in a DSS-induced colitis model, which was likely mediated by inhibiting the production of pro-inflammatory cytokines via the IL-6/STAT3 signaling pathway.	dss	103-106	interleukin 6	Mus musculus	223-227
33332758-11	2021	CONCLUSIONS: The upregulation of miR-223 by agomir administration alleviated colonic inflammation in a DSS-induced colitis model, which was likely mediated by inhibiting the production of pro-inflammatory cytokines via the IL-6/STAT3 signaling pathway.	dss	103-106	signal transducer and activator of transcription 3	Mus musculus	228-233
33879967-2	2021	We investigated the role of a core autophagy factor, Atg5, in the development of dextran sodium sulfate (DSS)-induced colitis.	dss	105-108	autophagy related 5	Mus musculus	53-57
33338506-9	2021	ER and PR expression were independent markers for DSS at cut-off values of 10% and 80%.	dss	50-53	estrogen receptor 1	Homo sapiens	0-2
33338506-9	2021	ER and PR expression were independent markers for DSS at cut-off values of 10% and 80%.	dss	50-53	progesterone receptor	Homo sapiens	7-9
33737336-8	2021	Patients with low IGJ had a 7.2-fold (p<0.001) increase in risk of disease-specific death with a median DSS of 13 months.	dss	104-107	joining chain of multimeric IgA and IgM	Homo sapiens	18-21
33737336-9	2021	Low IGJ showed an area under curve (AUC) of 0.89 with 91.0% sensitivity and 87.6% specificity to identify early disease-specific mortality (defined as DSS <=12 months).	dss	151-154	joining chain of multimeric IgA and IgM	Homo sapiens	4-7
33491282-7	2021	Conditional ITGB6 transgene expression exacerbated experimental colitis in mouse models of acute and chronic dextran sulphate sodium (DSS)-induced colitis.	dss	134-137	integrin beta 6	Mus musculus	12-17
33491282-8	2021	Survival analyses revealed that ITGB6 transgene expression correlated with poor prognosis in DSS-induced colitis.	dss	93-96	integrin beta 6	Mus musculus	32-37
33879967-9	2021	Apoptotic IECs were more abundant in DSS-treated Atg5 DeltaIEC mice.	dss	37-40	autophagy related 5	Mus musculus	49-53
33879967-7	2021	Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1alpha (IRE1alpha), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1alpha, were significantly enhanced in IECs in DSS-treated Atg5 DeltaIEC mice.	dss	236-239	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	79-88
33879967-7	2021	Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1alpha (IRE1alpha), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1alpha, were significantly enhanced in IECs in DSS-treated Atg5 DeltaIEC mice.	dss	236-239	endoplasmic reticulum (ER) to nucleus signalling 1	Mus musculus	186-195
32759976-7	2021	SLN positivity was associated with lower DSS, OS, and RFS rates at T1, T1a, and T1b stages.	dss	41-44	sarcolipin	Homo sapiens	0-3
33734413-16	2021	Conclusions and Relevance: This cohort study found that among patients with NF1, those who developed undifferentiated pleomorphic sarcoma, HGG, MPNST, ovarian carcinoma, or melanoma had significantly lower DSS rates compared with those who developed other neoplasms.	dss	206-209	neurofibromin 1	Homo sapiens	76-79
33485878-8	2021	In a western blot analysis, the DSS rats exhibited a significant decrease in GSK-3alpha/beta and an increase in the pGSK-3beta/GSK-3beta ratio, whereas AKT was not changed.	dss	32-35	glycogen synthase kinase 3 alpha	Rattus norvegicus	77-92
33485878-8	2021	In a western blot analysis, the DSS rats exhibited a significant decrease in GSK-3alpha/beta and an increase in the pGSK-3beta/GSK-3beta ratio, whereas AKT was not changed.	dss	32-35	glycogen synthase kinase 3 alpha	Rattus norvegicus	117-126
32588101-8	2021	Multivariate analysis showed significant prognostic influence for all tested CSC markers, with high BMI-1 and CD44 decreasing survival (BMI-1: OS, DFS, DSS; CD44: OS, DFS) and high ALDH1 and BCL11B showing a beneficial effect on survival (ALDH1: OS, DFS; BCL11B: OS, DSS).	dss	152-155	CD44 molecule (Indian blood group)	Homo sapiens	110-114
33555543-7	2021	RESULTS: Elevated baseline LDH and S100B correlated with impaired DSS.	dss	66-69	S100 calcium binding protein B	Homo sapiens	35-40
33485878-9	2021	CONCLUSIONS: Our results indicated that the DSS rats had hypofunction of the basal dopamine release and AKT/GSK-3 signaling even at 7 days after the antipsychotic was discontinued.	dss	44-47	AKT serine/threonine kinase 1	Rattus norvegicus	104-107
33485878-9	2021	CONCLUSIONS: Our results indicated that the DSS rats had hypofunction of the basal dopamine release and AKT/GSK-3 signaling even at 7 days after the antipsychotic was discontinued.	dss	44-47	glycogen synthase kinase 3 beta	Mus musculus	108-113
32940671-12	2021	Myeloperoxidase (acute inflammation) and FITC-dextran levels (intestinal permeability) were increased in AOM/DSS controls (p<0.05).	dss	109-112	myeloperoxidase	Mus musculus	0-15
33555543-10	2021	Patients with elevated S100B (P = 0.00062) but not with elevated LDH (P = 0.067) at the time point of radiologically confirmed PD showed significantly impaired DSS after PD.	dss	160-163	S100 calcium binding protein B	Homo sapiens	23-28
33555543-11	2021	Interestingly, DSS after PD differed significantly according to S100B levels determined as early as 8 weeks (median) before PD (P = 0.0024).	dss	15-18	S100 calcium binding protein B	Homo sapiens	64-69
33680927-8	2020	High VMA21 expression in tumors was also an independent predictor of DSS (hazard ratio, 0.345; 95% confidence interval, 0.123-0.976), with covariates included TNM stage and differentiation grade.	dss	69-72	vacuolar ATPase assembly factor VMA21	Homo sapiens	5-10
33668818-0	2021	Indol-3-Carbinol and Quercetin Ameliorate Chronic DSS-Induced Colitis in C57BL/6 Mice by AhR-Mediated Anti-Inflammatory Mechanisms.	dss	50-53	aryl-hydrocarbon receptor	Mus musculus	89-92
33632097-9	2021	DSS was shorter in patients with high expression levels of COL5A2 (p = 0.033) and CK14 (p = 0.042).	dss	0-3	collagen type V alpha 2 chain	Homo sapiens	59-65
33632097-9	2021	DSS was shorter in patients with high expression levels of COL5A2 (p = 0.033) and CK14 (p = 0.042).	dss	0-3	keratin 14	Homo sapiens	82-86
33249075-7	2021	DMH+DSS group showed a significant (P < 0.05) increase in the levels of AREG (2386+-18 vs 1377+-10 pg/ml), CXCL1 (18+-0.9 vs 6+-0.83 <mu>g/ml), MMP-9 (1355+-88 vs 452+-7 pg/ml) compared to normal rats.	dss	4-7	amphiregulin	Rattus norvegicus	72-76
33665583-3	2021	Here, we found that Elf4 -/- mice developed colon tumors with 3 cycles of dextran sulfate sodium salt (DSS) treatment alone.	dss	103-106	E74-like factor 4 (ets domain transcription factor)	Mus musculus	20-24
33665583-4	2021	We further showed that ELF4 suppression was prevalent in both patients with UC and DSS-induced mice models, and this suppression was caused by promoter region methylation.	dss	83-86	E74 like ETS transcription factor 4	Homo sapiens	23-27
33546179-5	2021	Submandibular gland ACCs had the worst prognosis (adjusted DSS HR = 1.48; 95% CI = 0.99-2.20, compared to parotid), and this difference was more pronounced among patients with advanced-stage tumors (adjusted DSS HR = 1.93; 95% CI = 1.13-3.30).	dss	59-62	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	20-24
33546179-5	2021	Submandibular gland ACCs had the worst prognosis (adjusted DSS HR = 1.48; 95% CI = 0.99-2.20, compared to parotid), and this difference was more pronounced among patients with advanced-stage tumors (adjusted DSS HR = 1.93; 95% CI = 1.13-3.30).	dss	208-211	1-aminocyclopropane-1-carboxylate synthase homolog (inactive)	Homo sapiens	20-24
33584100-13	2021	Conclusion: EA at ST36 with a special set of parameters has no effect on reduced rectal compliance but relieves visceral hypersensitivity via the mast cells-triggered NGF/TrkA/TRPV1 peripheral afferent pathway in DSS-treated post-inflammation rats.	dss	213-216	nerve growth factor	Rattus norvegicus	167-170
33249075-7	2021	DMH+DSS group showed a significant (P < 0.05) increase in the levels of AREG (2386+-18 vs 1377+-10 pg/ml), CXCL1 (18+-0.9 vs 6+-0.83 <mu>g/ml), MMP-9 (1355+-88 vs 452+-7 pg/ml) compared to normal rats.	dss	4-7	C-X-C motif chemokine ligand 1	Rattus norvegicus	107-112
33249075-7	2021	DMH+DSS group showed a significant (P < 0.05) increase in the levels of AREG (2386+-18 vs 1377+-10 pg/ml), CXCL1 (18+-0.9 vs 6+-0.83 <mu>g/ml), MMP-9 (1355+-88 vs 452+-7 pg/ml) compared to normal rats.	dss	4-7	matrix metallopeptidase 9	Rattus norvegicus	144-149
32350653-1	2021	PURPOSE: The study aimed to investigate the discrepancy and potential mechanisms of different CLA-producing B. breve on dextran sulphate sodium (DSS)-induced colitis.	dss	145-148	clasper	Mus musculus	94-97
33535045-5	2021	Myofibroblast MyD88-deficient mice are resistant to azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced tumorigenesis, as evidenced by the decrease in the number and sizes of tumors.	dss	95-98	myeloid differentiation primary response gene 88	Mus musculus	14-19
33535045-6	2021	MyD88 deficiency in myofibroblasts attenuates intestinal epithelial cell (IEC) proliferation after acute DSS-induced colitis.	dss	105-108	myeloid differentiation primary response gene 88	Mus musculus	0-5
33341450-5	2021	RESULTS: Low levels of CDX2 protein expression in stage II and III colon cancer as determined by immunohistochemistry was associated with poor DSS (hazard ratio [HR] = 1.97 (95% confidence interval [CI]: 1.26-3.06); p = 0.002).	dss	143-146	caudal type homeobox 2	Homo sapiens	23-27
32350653-10	2021	CONCLUSIONS: Bifidobacterium breve M1 and B. breve M2 alleviated DSS-induced colitis by producing CLA, inhibiting the inflammatory cytokines, maintaining of the intestinal epithelial barrier and regulating the gut microbiota.	dss	65-68	clasper	Mus musculus	98-101
33510215-0	2021	Protective effects of growth hormone-releasing hormone analogs in DSS-induced colitis in mice.	dss	66-69	growth hormone releasing hormone	Mus musculus	22-54
33516524-8	2021	51 patients with M1/CT>1, showed a lower median DSS (35.4 months vs 55.8; p=0.002) and DFS (14.2 months vs 29.3; p=0.025) compared to 470 with M1/CT<=1.	dss	48-51	cholinergic receptor muscarinic 1	Homo sapiens	17-24
33510215-9	2021	Furthermore, MIA-690 decreased serum insulin-like growth factor (IGF)-1 levels in mice DSS-treated, respect to MR-409.	dss	87-90	insulin-like growth factor 1	Mus musculus	37-71
33481184-5	2021	Log-rank test showed that podoplanin-positive status in CAFs correlated with shorter disease-free survival (DFS) (p = 0.007) and disease-specific survival (DSS) (p < 0.001).	dss	156-159	podoplanin	Homo sapiens	26-36
33508876-4	2021	DSS-treated rats showed mucosal damage, colonic inflammation, and elevated myeloperoxidase activity compared with the healthy controls.	dss	0-3	myeloperoxidase	Rattus norvegicus	75-90
33508876-7	2021	The miR-330 overexpression reduced DSS-induced colonic injury and the production of proinflammatory cytokines.	dss	35-38	microRNA 330	Rattus norvegicus	4-11
33508876-9	2021	IRAK1 overexpression abolished the protective effect of miR-330 on DSS-induced colonic inflammation and mucosal injury in rats.	dss	67-70	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	0-5
33508876-9	2021	IRAK1 overexpression abolished the protective effect of miR-330 on DSS-induced colonic inflammation and mucosal injury in rats.	dss	67-70	microRNA 330	Rattus norvegicus	56-63
33508876-10	2021	In conclusion, we clarify the role of miR-330 in pathogenesis of UC, suggesting miR-330 alleviated DSS-induced colitis by downregulating IRAK1, shedding lights on miR-330 as a therapeutic candidate for UC treatment.	dss	99-102	microRNA 330	Rattus norvegicus	38-45
33508876-10	2021	In conclusion, we clarify the role of miR-330 in pathogenesis of UC, suggesting miR-330 alleviated DSS-induced colitis by downregulating IRAK1, shedding lights on miR-330 as a therapeutic candidate for UC treatment.	dss	99-102	microRNA 330	Rattus norvegicus	80-87
33508876-10	2021	In conclusion, we clarify the role of miR-330 in pathogenesis of UC, suggesting miR-330 alleviated DSS-induced colitis by downregulating IRAK1, shedding lights on miR-330 as a therapeutic candidate for UC treatment.	dss	99-102	interleukin-1 receptor-associated kinase 1	Rattus norvegicus	137-142
33508876-10	2021	In conclusion, we clarify the role of miR-330 in pathogenesis of UC, suggesting miR-330 alleviated DSS-induced colitis by downregulating IRAK1, shedding lights on miR-330 as a therapeutic candidate for UC treatment.	dss	99-102	microRNA 330	Rattus norvegicus	80-87
33483420-6	2021	Moreover, mice with Paneth cell-specific depletion of Dhx15 (Dhx15 f/f Defensinalpha6-cre, Dhx15DeltaPaneth) are more susceptible to DSS (dextran sodium sulfate)-induced colitis, which phenocopy Dhx15DeltaIEC mice, due to the dysbiosis of the intestinal microbiota.	dss	133-136	DEAH (Asp-Glu-Ala-His) box polypeptide 15	Mus musculus	54-59
33483420-6	2021	Moreover, mice with Paneth cell-specific depletion of Dhx15 (Dhx15 f/f Defensinalpha6-cre, Dhx15DeltaPaneth) are more susceptible to DSS (dextran sodium sulfate)-induced colitis, which phenocopy Dhx15DeltaIEC mice, due to the dysbiosis of the intestinal microbiota.	dss	133-136	DEAH (Asp-Glu-Ala-His) box polypeptide 15	Mus musculus	61-66
33481184-7	2021	According to Cox multivariate analysis, podoplanin-positive status in CAFs had the most significant effect on shorter DSS (HR = 37.759; p = 0.003) followed by high Ki67LI (HR = 27.664; p = 0.007).	dss	118-121	podoplanin	Homo sapiens	40-50
33452178-9	2022	Compared with wild-type (WT) control mice, the colon of Entpd8 -/- mice treated with DSS displayed significantly more histological damage, immune cell infiltration, apoptosis and increased expression of several proinflammatory cytokines.	dss	85-88	ectonucleoside triphosphate diphosphohydrolase 8	Mus musculus	56-62
33452178-11	2022	Irradiated P2ry6 -/- mice transplanted with WT bone marrow were fully protected from DSS-induced intestinal inflammation.	dss	85-88	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	11-16
33452178-12	2022	In agreement, the daily intrarectal injection of a P2Y6 antagonist protected mice from DSS-induced intestinal inflammation in a dose-dependent manner.	dss	87-90	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	51-55
33422110-9	2021	The DSS also increased the impact of LPS plus paraquat upon microglial morphology, along with circulating lipocalin-2 (neutrophil marker) and IL-6.	dss	4-7	lipocalin 2	Mus musculus	106-117
33422110-9	2021	The DSS also increased the impact of LPS plus paraquat upon microglial morphology, along with circulating lipocalin-2 (neutrophil marker) and IL-6.	dss	4-7	interleukin 6	Mus musculus	142-146
33221281-9	2021	And Ts-EVs prevented the increase in the expression of TNF-alpha, IFN-gamma, IL-17A and IL-1beta observed in the colon of DSS-treated mice.	dss	122-125	tumor necrosis factor	Mus musculus	55-64
33413675-0	2021	Dental pulp stem cells overexpressing hepatocyte growth factor facilitate the repair of DSS-induced ulcerative colitis.	dss	88-91	hepatocyte growth factor	Rattus norvegicus	38-62
33221281-9	2021	And Ts-EVs prevented the increase in the expression of TNF-alpha, IFN-gamma, IL-17A and IL-1beta observed in the colon of DSS-treated mice.	dss	122-125	interferon gamma	Mus musculus	66-75
33221281-9	2021	And Ts-EVs prevented the increase in the expression of TNF-alpha, IFN-gamma, IL-17A and IL-1beta observed in the colon of DSS-treated mice.	dss	122-125	interleukin 17A	Mus musculus	77-83
33221281-9	2021	And Ts-EVs prevented the increase in the expression of TNF-alpha, IFN-gamma, IL-17A and IL-1beta observed in the colon of DSS-treated mice.	dss	122-125	interleukin 1 alpha	Mus musculus	88-96
33221281-12	2021	The expression of CD206 (M2 marker) in the mesenteric lymph nodes (MLN) of mice with colitis increased in Ts-EVs+DSS group.	dss	113-116	mannose receptor, C type 1	Mus musculus	18-23
33075564-3	2021	METHOD: Fibrinogen level was measured in dextran sulphate sodium (DSS)-induced colitis and patients with ulcerative colitis.	dss	66-69	fibrinogen beta chain	Homo sapiens	8-18
32659381-7	2021	Antibiotics treatment rendered Muc2+/+ but not Muc2-/- littermates highly susceptibility to DSS-induced colitis that was ILC3 dependent.	dss	92-95	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	31-35
32659381-8	2021	Muc2-/- microbiota was colitogenic to Muc2+/+ as it worsened DSS-induced colitis.	dss	61-64	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	0-4
32659381-8	2021	Muc2-/- microbiota was colitogenic to Muc2+/+ as it worsened DSS-induced colitis.	dss	61-64	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	38-42
33075564-6	2021	RESULTS: Through Tandem Mass Tag (TMT)-based quantitative proteomics, fibrinogen (Fg) was found to be upregulated in the colon of DSS-treated mice, which was consistent with increased Fg level in colon sample of patients with ulcerative colitis.	dss	130-133	fibrinogen beta chain	Homo sapiens	70-80
33075564-10	2021	Moreover, activation of AKT was found in vessels of DSS-treated mice.	dss	52-55	thymoma viral proto-oncogene 1	Mus musculus	24-27
33240413-7	2021	In the parts of colon tumors from AOM/DSS mice, particularly in mice at 30 weeks, the positive signal of E-cadherin was clearly reduced in the cell membranes.	dss	38-41	cadherin 1	Mus musculus	105-115
33047284-10	2021	Further animal experiments showed that TUG1 overexpression attenuated UC progression in the DSS-induced UC in mice.	dss	92-95	taurine upregulated gene 1	Mus musculus	39-43
33110234-9	2021	We further demonstrated that Gal2-KO mice developed significantly larger tumors than WT mice using Azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced colorectal cancer model.	dss	142-145	lectin, galactose-binding, soluble 2	Mus musculus	29-33
33296813-6	2021	STUDY DESIGN: We used the dextran sodium sulphate (DSS)-induced UC model in mice, TNF-alpha-damaged NCM460 colonic epithelial cells, macrophage cells THP-M stimulated with lipopolysaccharide (LPS) / adenosine triphosphate (ATP) and compound C (an AMPK inhibitor) to confirm the key role of AMPK (AMP-activated protein kinase) activation.	dss	51-54	tumor necrosis factor	Mus musculus	82-91
33240413-8	2021	The percentage of Ki67-positive tumor cells in mucosal areas of AOM/DSS mice was higher than that in the sites of submucosal infiltration.	dss	68-71	antigen identified by monoclonal antibody Ki 67	Mus musculus	18-22
33240413-11	2021	In colon tumors from AOM/DSS mice at 30 weeks, the percentage of pSmad2/3L-Thr-positive cells among the nuclear beta-catenin-positive tumor cells was higher than that among the cytoplasmic beta-catenin-positive tumor cells.	dss	25-28	catenin (cadherin associated protein), beta 1	Mus musculus	112-124
33240413-11	2021	In colon tumors from AOM/DSS mice at 30 weeks, the percentage of pSmad2/3L-Thr-positive cells among the nuclear beta-catenin-positive tumor cells was higher than that among the cytoplasmic beta-catenin-positive tumor cells.	dss	25-28	catenin (cadherin associated protein), beta 1	Mus musculus	189-201
33425760-11	2020	Multivariate survival analysis showed that HTRA3 was an independent prognostic marker for PFI (HR: 1.456; CI: 1.021-2.078; P = 0.038), DSS (HR: 1.650; CI: 1.079-2.522; P = 0.021) and OS [hazard ratio (HR): 1.590; 95% confidence interval (CI):1.140-2.219; P = 0.006].	dss	135-138	HtrA serine peptidase 3	Homo sapiens	43-48
33519451-5	2020	Experimental colitis was evoked by 2% dextran sodium sulfate (DSS) in AnxA1 knockout (AnxA1-/-) or wild type (WT) C57BL/6 mice.	dss	62-65	annexin A1	Mus musculus	70-75
33172329-3	2021	Esrra-deficient mice presented with increased susceptibility to dextran sodium sulfate (DSS)-induced colitis with upregulation of intestinal inflammation.	dss	88-91	estrogen related receptor, alpha	Mus musculus	0-5
33172329-6	2021	Cohousing or fecal microbiota transplantation from WT mice to Esrra-deficient mice ameliorated DSS-induced colitis severity.	dss	95-98	estrogen related receptor, alpha	Mus musculus	62-67
32942916-8	2020	Plasma levels of TNF-alpha and IL-6 in DSS-treated mice was higher than that of control.	dss	39-42	tumor necrosis factor	Mus musculus	17-26
33409321-9	2020	Conclusion: It can be concluded that neem leaf extract decreased the expression of TNF-alpha and IL-6 in DSS-induced colitis.	dss	105-108	interleukin 6	Rattus norvegicus	97-101
32805281-5	2020	CCAT2 transgene and control mice were given azoxymethane and dextran sulphate sodium (DSS) to induce colon tumors.	dss	86-89	colon cancer associated transcript 2	Homo sapiens	0-5
33409321-1	2020	Objective: We aimed to determine the neem leaf extract"s effect on Tumor Necrosis Factor-alpha (TNF-alpha) and Interleukin-6 (IL-6) expressions in dextran sodium sulfate (DSS)-induced colitis rats.	dss	171-174	tumor necrosis factor	Rattus norvegicus	96-105
33409321-1	2020	Objective: We aimed to determine the neem leaf extract"s effect on Tumor Necrosis Factor-alpha (TNF-alpha) and Interleukin-6 (IL-6) expressions in dextran sodium sulfate (DSS)-induced colitis rats.	dss	171-174	interleukin 6	Rattus norvegicus	126-130
33409321-9	2020	Conclusion: It can be concluded that neem leaf extract decreased the expression of TNF-alpha and IL-6 in DSS-induced colitis.	dss	105-108	tumor necrosis factor	Rattus norvegicus	83-92
32942916-8	2020	Plasma levels of TNF-alpha and IL-6 in DSS-treated mice was higher than that of control.	dss	39-42	interleukin 6	Mus musculus	31-35
32942916-11	2020	The distribution of aquaporin-5 expressed in the lacrimal gland of DSS-treated mice was decreased compared to that in the control group.Conclusions: These findings suggest that a decrease in the tear volume in UC was associated with a functional decline in the inflamed lacrimal gland.	dss	67-70	aquaporin 5	Mus musculus	20-31
32781075-13	2020	SIGNIFICANCE: TL1A exacerbated DSS-induced chronic experimental colitis, probably through activation and migration of dendritic cells, and therefore increasing the secretion of proinflammatory cytokines.	dss	31-34	tumor necrosis factor (ligand) superfamily, member 15	Mus musculus	14-18
32581195-8	2020	AOM/DSS-treated Pierce1 TG mice were comparable with respect to colon lengths, the number of polyps, and tumor sizes to those of the control mice.	dss	4-7	piercer of microtubule wall 1	Mus musculus	16-23
33255617-7	2020	High density of LLT1-positive tumor-infiltrating lymphocytes (TIL) was also frequently detected in 160 (73%) OPSCC samples, and significantly associated with better DSS and OS (p < 0.001 and p = 0.007, respectively).	dss	165-168	C-type lectin domain family 2 member D	Homo sapiens	16-20
33255617-8	2020	Multivariate Cox analysis further revealed that tumoral LLT1 expression and infiltration of LLT1-positive TIL were independent prognostic factors for DSS and OS.	dss	150-153	C-type lectin domain family 2 member D	Homo sapiens	56-60
33255617-8	2020	Multivariate Cox analysis further revealed that tumoral LLT1 expression and infiltration of LLT1-positive TIL were independent prognostic factors for DSS and OS.	dss	150-153	C-type lectin domain family 2 member D	Homo sapiens	92-96
32892075-11	2020	In conclusion, DHA could protect DSS-induced colitis via suppressing the activation of NLRP3 inflammasome and p38 MAPK signaling.	dss	33-36	NLR family pyrin domain containing 3	Homo sapiens	87-92
33202783-5	2020	(3) Results: A conditional knockout of myeloid Hif-1a ameliorated whereas the knockout of Hif-2a aggravated murine DSS colitis by increased recruitment of neutrophils to deeper layers of the colon.	dss	115-118	endothelial PAS domain protein 1	Mus musculus	90-96
33160389-8	2020	Furthermore, treatment with neutralizing anti-HMGB1 antibodies decreased the numbers and sizes of tumors, ERK1/2 activation and proliferating cell nuclear antigen (PCNA) expression in AOM/DSS-challenged WT mice.	dss	188-191	high mobility group box 1	Mus musculus	46-51
33160389-8	2020	Furthermore, treatment with neutralizing anti-HMGB1 antibodies decreased the numbers and sizes of tumors, ERK1/2 activation and proliferating cell nuclear antigen (PCNA) expression in AOM/DSS-challenged WT mice.	dss	188-191	proliferating cell nuclear antigen	Mus musculus	164-168
32945118-4	2020	Intriguingly, DSC specifically down-regulated DSS-induced colonic NADPH oxidase 4 (Nox4) expression, accompanied by a balanced redox status, suppressed nuclear factor-kappaB (NF-kappaB) and NLRP3 inflammasome activation and up-regulated nuclear factor (erythroid-derived 2)-like 2 and haeme oxygenase-1 expression.	dss	46-49	NADPH oxidase 4	Homo sapiens	66-81
32945118-4	2020	Intriguingly, DSC specifically down-regulated DSS-induced colonic NADPH oxidase 4 (Nox4) expression, accompanied by a balanced redox status, suppressed nuclear factor-kappaB (NF-kappaB) and NLRP3 inflammasome activation and up-regulated nuclear factor (erythroid-derived 2)-like 2 and haeme oxygenase-1 expression.	dss	46-49	NADPH oxidase 4	Homo sapiens	83-87
32945118-4	2020	Intriguingly, DSC specifically down-regulated DSS-induced colonic NADPH oxidase 4 (Nox4) expression, accompanied by a balanced redox status, suppressed nuclear factor-kappaB (NF-kappaB) and NLRP3 inflammasome activation and up-regulated nuclear factor (erythroid-derived 2)-like 2 and haeme oxygenase-1 expression.	dss	46-49	nuclear factor kappa B subunit 1	Homo sapiens	152-173
32945118-4	2020	Intriguingly, DSC specifically down-regulated DSS-induced colonic NADPH oxidase 4 (Nox4) expression, accompanied by a balanced redox status, suppressed nuclear factor-kappaB (NF-kappaB) and NLRP3 inflammasome activation and up-regulated nuclear factor (erythroid-derived 2)-like 2 and haeme oxygenase-1 expression.	dss	46-49	nuclear factor kappa B subunit 1	Homo sapiens	175-184
32945118-4	2020	Intriguingly, DSC specifically down-regulated DSS-induced colonic NADPH oxidase 4 (Nox4) expression, accompanied by a balanced redox status, suppressed nuclear factor-kappaB (NF-kappaB) and NLRP3 inflammasome activation and up-regulated nuclear factor (erythroid-derived 2)-like 2 and haeme oxygenase-1 expression.	dss	46-49	NLR family pyrin domain containing 3	Homo sapiens	190-195
32963603-12	2020	Furthermore, tumor size, TNM stage and GPC1 expression were independent predictive factors for RFS and DSS in patients with HCC.	dss	103-106	glypican 1	Homo sapiens	39-43
32932170-8	2020	Moreover, triple-positive cases (NOTCH1+/HES1+/p21+) exhibited significantly improved DSS (P < 0.001) and OS (P = 0.004), thus reinforcing the association of NOTCH pathway activation with a better prognosis in HNSCC.	dss	86-89	notch receptor 1	Homo sapiens	33-39
32932170-8	2020	Moreover, triple-positive cases (NOTCH1+/HES1+/p21+) exhibited significantly improved DSS (P < 0.001) and OS (P = 0.004), thus reinforcing the association of NOTCH pathway activation with a better prognosis in HNSCC.	dss	86-89	hes family bHLH transcription factor 1	Homo sapiens	41-45
32932170-8	2020	Moreover, triple-positive cases (NOTCH1+/HES1+/p21+) exhibited significantly improved DSS (P < 0.001) and OS (P = 0.004), thus reinforcing the association of NOTCH pathway activation with a better prognosis in HNSCC.	dss	86-89	cyclin dependent kinase inhibitor 1A	Homo sapiens	47-50
32932170-9	2020	Multivariate analysis further revealed membranous NOTCH1 expression as a robust independent predictor of better DSS (HR = 0.554; 95% IC 0.412-0.745; P < 0.001) and better OS (HR = 0.640; 95% CI 0.491-0.835; P = 0.001).	dss	112-115	notch receptor 1	Homo sapiens	50-56
33194662-11	2020	Kaplan-Meier analysis demonstrated associations of high FBLN2 expression with worse DSS (p < 0.001) and MFS (p < 0.001).	dss	84-87	fibulin 2	Homo sapiens	56-61
32424768-8	2020	Among patients with local Dukes B disease, a strong TLR4 immunoactivity associated with a worse disease-specific survival (DSS; p = 0.017).	dss	123-126	toll like receptor 4	Homo sapiens	52-56
33194662-12	2020	Furthermore, multivariate analysis identified high FBLN2 expression as an independent predictive risk factor for DSS [hazard ratio (HR) in UBUC, 2.306, p = 0.014; in UTUC, 2.561, p = 0.012] and MFS (HR in UBUC, 2.493, p = 0.001; in UTUC, 2.837, p = 0.001).	dss	113-116	fibulin 2	Homo sapiens	51-56
33121008-12	2020	Chga-/- M2-conditioned supernatant protected caco-2 cells from DSS and oxidative stress injuries by improving caco-2 cells functions (proliferation, viability, wound healing) and by decreasing the release of IL-8 and IL-18 and by maintaining the levels of TJ proteins, and when compared with Chga+/+ M2-conditioned supernatant.	dss	63-66	chromogranin A	Homo sapiens	0-4
33108032-7	2020	Animal experiments showed that Treg-Exo administration alleviated the DSS-induced IBD in mice.	dss	70-73	5'-3' exoribonuclease 1	Mus musculus	36-39
33108032-10	2020	In conclusion, Treg-Exo alleviated the DSS-induced IBD through transferring miR-195a-3p.	dss	39-42	5'-3' exoribonuclease 1	Mus musculus	20-23
33087357-3	2020	Mice with macrophage-specific CD1d1 deficiency (LymCD1d1-/- ) acquire resistance to dextran sodium sulfate (DSS)-induced colitis, attributing to the transcriptional inhibition of NLRP3 inflammasome components.	dss	108-111	CD1d1 antigen	Mus musculus	30-35
33106498-6	2020	A "modified" staging schema discarding strap muscle invasion as a T stage criterion showed better 10-year DSS distinction between T stages.	dss	106-109	serine/threonine kinase receptor associated protein	Homo sapiens	39-44
33087357-3	2020	Mice with macrophage-specific CD1d1 deficiency (LymCD1d1-/- ) acquire resistance to dextran sodium sulfate (DSS)-induced colitis, attributing to the transcriptional inhibition of NLRP3 inflammasome components.	dss	108-111	NLR family, pyrin domain containing 3	Mus musculus	179-184
33087357-6	2020	Therefore, the counterbalancing role of CD1d1 in macrophages appears to determine severity of DSS-mediated colitis in mice.	dss	94-97	CD1d1 antigen	Mus musculus	40-45
33082414-7	2020	In addition, a significant difference was achieved (p = 0.039) in 5-year survival rates of DSS: 65% for low, 72% for moderate, and 88% for high Talin1 protein expression.	dss	91-94	talin 1	Homo sapiens	144-150
33082414-8	2020	Observations showed that lower expression of Talin1 at both the gene and protein level may drive the disparity of CRC patients" outcomes via worse DSS and provide new insights into the development of progression indicators because of its correlation with increased tumor aggressiveness.	dss	147-150	talin 1	Homo sapiens	45-51
33052885-3	2020	APPROACH: To address this, we implemented a dynamic stopping strategy (DSS) to maintain the P300 speller LRA when performing multiple tasks simultaneously.	dss	71-74	E1A binding protein p300	Homo sapiens	92-96
33052885-6	2020	MAIN RESULTS: Online experimental results showed that the P300 speller with DSS could achieve a high LRA (96.9%) under dual-task, which was similar to single-task (98.7%, p = 0.126).	dss	76-79	E1A binding protein p300	Homo sapiens	58-62
33052885-8	2020	Therefore, DSS can increase the repeated sequences to compensate for the reduction of P300 speller signal-to-noise ratio caused by parallel thinking activities.	dss	11-14	E1A binding protein p300	Homo sapiens	86-90
33050010-16	2020	The presence of macrophages in survivin-positive or ERBB2-positive tumors was associated with worse DSS.	dss	100-103	erb-b2 receptor tyrosine kinase 2	Homo sapiens	52-57
33023507-8	2020	Significant differences in DSS were found according to age, race, tumour type, AJCC/TNM stage, surgery, radiotherapy, chemotherapy and different treatment modalities (P < 0.05).	dss	27-30	teneurin transmembrane protein 1	Homo sapiens	84-87
33162890-4	2020	Colitis was induced in CD1 mice by 4% w/v DSS in drinking water for five consecutive days followed by normal drinking water.	dss	42-45	CD1 antigen complex	Mus musculus	23-26
32640308-10	2020	RESULTS: CHL1 expression was upregulated in DSS-induced IBD mice.	dss	44-47	cell adhesion molecule L1-like	Mus musculus	9-13
32640308-13	2020	Number of neutrophils, macrophages and T cells, and expression of TNF-alpha, IL-6, IL-17A, IL-21 and IL-23 were decreased in DSS-CHLl-KO mice, while IL-10 expression was increased.	dss	125-128	tumor necrosis factor	Mus musculus	66-75
32640308-13	2020	Number of neutrophils, macrophages and T cells, and expression of TNF-alpha, IL-6, IL-17A, IL-21 and IL-23 were decreased in DSS-CHLl-KO mice, while IL-10 expression was increased.	dss	125-128	interleukin 6	Mus musculus	77-81
32640308-13	2020	Number of neutrophils, macrophages and T cells, and expression of TNF-alpha, IL-6, IL-17A, IL-21 and IL-23 were decreased in DSS-CHLl-KO mice, while IL-10 expression was increased.	dss	125-128	interleukin 17A	Mus musculus	83-89
32640308-13	2020	Number of neutrophils, macrophages and T cells, and expression of TNF-alpha, IL-6, IL-17A, IL-21 and IL-23 were decreased in DSS-CHLl-KO mice, while IL-10 expression was increased.	dss	125-128	interleukin 21	Mus musculus	91-96
32640308-13	2020	Number of neutrophils, macrophages and T cells, and expression of TNF-alpha, IL-6, IL-17A, IL-21 and IL-23 were decreased in DSS-CHLl-KO mice, while IL-10 expression was increased.	dss	125-128	interleukin 23, alpha subunit p19	Mus musculus	101-106
32640308-13	2020	Number of neutrophils, macrophages and T cells, and expression of TNF-alpha, IL-6, IL-17A, IL-21 and IL-23 were decreased in DSS-CHLl-KO mice, while IL-10 expression was increased.	dss	125-128	interleukin 10	Mus musculus	149-154
32448984-9	2020	However, in multivariate analysis, only high density of CD8+ TIL was associated with a better DSS (P = 0.002).	dss	94-97	CD8a molecule	Homo sapiens	56-59
33117347-0	2020	Excretory/Secretory Products From Trichinella spiralis Adult Worms Attenuated DSS-Induced Colitis in Mice by Driving PD-1-Mediated M2 Macrophage Polarization.	dss	78-81	programmed cell death 1	Mus musculus	117-121
33117347-14	2020	In conclusion, the protective effects of T. spiralis AES on DSS-induced colitis were found to associate with PD-1 upregulation and M2 macrophage polarization.	dss	60-63	programmed cell death 1	Mus musculus	109-113
32448984-9	2020	However, in multivariate analysis, only high density of CD8+ TIL was associated with a better DSS (P = 0.002).	dss	94-97	toll like receptor 1	Homo sapiens	61-64
32893621-5	2020	In addition, DSS-induced inflammatory responses were inhibited by sesamol supplementation via the NF-kappaB signaling pathway in mice colon.	dss	13-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	98-107
32227170-7	2020	Investigating the role of Reg3B as a protective factor in colitis, we found that Reg3B-KO mice display increased inflammation and less crypt proliferation in the DSS colitis model.	dss	162-165	regenerating islet-derived 3 beta	Mus musculus	81-86
32227170-9	2020	Treatment of organoids exposed to DSS with Reg3B or propionate reversed the chemical injury with a loss of expression of the stem-cell marker Lgr5 and Olfm4.	dss	34-37	regenerating islet-derived 3 beta	Mus musculus	43-48
32227170-9	2020	Treatment of organoids exposed to DSS with Reg3B or propionate reversed the chemical injury with a loss of expression of the stem-cell marker Lgr5 and Olfm4.	dss	34-37	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	142-146
32227170-9	2020	Treatment of organoids exposed to DSS with Reg3B or propionate reversed the chemical injury with a loss of expression of the stem-cell marker Lgr5 and Olfm4.	dss	34-37	olfactomedin 4	Mus musculus	151-156
32589883-9	2020	RESULTS: Mice with IEC-specific loss of MHCII (I-AbDeltaIEC mice) developed less severe DSS- or T-cell transfer-induced colitis than control mice.	dss	88-91	histocompatibility-2, MHC	Mus musculus	40-45
32589883-14	2020	CONCLUSIONS: In mice with DSS or T cell-induced colitis, loss of MHCII from IECs reduces but does not eliminate mucosal inflammation.	dss	26-29	histocompatibility-2, MHC	Mus musculus	65-70
32591441-8	2020	In further experiments, we found that the levels of IL-10 were elevated in the serum of Azoxymethane (AOM)/Dextran Sodium Sulfate (DSS)-treated AURKAflox/+;VillinCre+ mice.	dss	131-134	interleukin 10	Mus musculus	52-57
32768945-9	2020	Colonic CD19+ CD1dhi and CD19+ TIM-1+ cells were also increased in astilbin-treated mice with DSS-induced colitis.	dss	94-97	CD19 antigen	Mus musculus	8-12
33003392-6	2020	Lower CXCL9 mRNA was observed in multivariate Cox"s regression analysis to be an independent prognostic parameter for reduced OS (relative risk; RR = 2.08; p = 0.049), DSS (RR = 4.49; p = 0.006) and RFS (RR = 2.69; p = 0.005).	dss	168-171	C-X-C motif chemokine ligand 9	Homo sapiens	6-11
33003392-7	2020	In addition, PD-L1 mRNA was an independent prognostic factor for DSS (RR = 5.02; p = 0.042) and RFS (RR = 2.07; p = 0.044).	dss	65-68	CD274 molecule	Homo sapiens	13-18
32559625-9	2020	OEA restored mRNA transcription of PPAR-alpha, of tight junctions and protective factors of colon integrity disrupted by DSS.	dss	121-124	peroxisome proliferator activated receptor alpha	Mus musculus	35-45
32768945-9	2020	Colonic CD19+ CD1dhi and CD19+ TIM-1+ cells were also increased in astilbin-treated mice with DSS-induced colitis.	dss	94-97	CD1 antigen complex	Mus musculus	8-11
32768945-9	2020	Colonic CD19+ CD1dhi and CD19+ TIM-1+ cells were also increased in astilbin-treated mice with DSS-induced colitis.	dss	94-97	CD19 antigen	Mus musculus	25-29
32768945-9	2020	Colonic CD19+ CD1dhi and CD19+ TIM-1+ cells were also increased in astilbin-treated mice with DSS-induced colitis.	dss	94-97	thymoma insertional mutation	Mus musculus	31-36
32768945-10	2020	The adoptive transfer of CD19+ TIM-1+ cells pre-induced by astilbin/LPS directly suppressed the progression of DSS-induced colitis.	dss	111-114	CD19 antigen	Mus musculus	25-29
32768945-10	2020	The adoptive transfer of CD19+ TIM-1+ cells pre-induced by astilbin/LPS directly suppressed the progression of DSS-induced colitis.	dss	111-114	thymoma insertional mutation	Mus musculus	31-36
32553747-1	2020	BACKGROUND: This study aimed to investigate the role of Clostridium butyricum (C. butyricum) in conjunction with the Toll-like receptor2 (TLR2) signaling pathway and T helper 17 (Th17) cells in dextran sodium sulfate (DSS)-induced colitis in mice.	dss	218-221	toll-like receptor 2	Mus musculus	138-142
32963733-0	2020	Glutamine relieves oxidative stress through PI3K/Akt signaling pathway in DSS-induced ulcerative colitis mice.	dss	74-77	thymoma viral proto-oncogene 1	Mus musculus	49-52
32563803-8	2020	Our study demonstrated that the protective therapeutic action of SIFs on DSS-induced colitis depended on inhibition of ERalpha and subsequent NLRP3 inflammasome activation, and SIFs are promising therapeutic agents for the treatment of colitis.	dss	73-76	estrogen receptor 1 (alpha)	Mus musculus	119-126
32563803-8	2020	Our study demonstrated that the protective therapeutic action of SIFs on DSS-induced colitis depended on inhibition of ERalpha and subsequent NLRP3 inflammasome activation, and SIFs are promising therapeutic agents for the treatment of colitis.	dss	73-76	NLR family, pyrin domain containing 3	Mus musculus	142-147
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	tumor necrosis factor	Homo sapiens	249-258
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	interleukin 1 alpha	Homo sapiens	260-269
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	C-C motif chemokine ligand 4	Homo sapiens	271-275
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	C-C motif chemokine ligand 8	Homo sapiens	277-281
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	C-C motif chemokine ligand 11	Homo sapiens	283-288
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	C-X-C motif chemokine ligand 5	Homo sapiens	290-295
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	C-X-C motif chemokine ligand 9	Homo sapiens	297-302
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	C-X-C motif chemokine ligand 10	Homo sapiens	304-310
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	selectin L	Homo sapiens	312-316
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	selectin E	Homo sapiens	318-322
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	epithelial cell adhesion molecule	Homo sapiens	324-329
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	neutrophil cytosolic factor 2	Homo sapiens	337-341
32779098-4	2021	Our results demonstrated that DSS administration can alter the epithelial barrier created in vitro by PIE cells and induce a potent inflammatory response, characterized by increases in the expression levels of several inflammatory factors including TNF-alpha, IL-1alpha, CCL4, CCL8, CCL11, CXCL5, CXCL9, CXCL10, SELL, SELE, EPCAM, VCAM, NCF2, and SAA2.	dss	30-33	serum amyloid A2	Homo sapiens	347-351
32563803-7	2020	Furthermore, ERalpha blockade ameliorated DSS-induced inflammatory responses in the intestine, and SIFs markedly suppressed the expression of ERalpha in a dose-dependent manner.	dss	42-45	estrogen receptor 1 (alpha)	Mus musculus	13-20
32817263-6	2020	Knocking out DDX5 in epithelial cells protected mice from intestinal tumorigenesis and dextran sodium sulfate (DSS)-induced colitis.	dss	111-114	DEAD box helicase 5	Mus musculus	13-17
32447215-0	2020	Prostaglandin E receptor EP4 stimulates lymphangiogenesis to promote mucosal healing during DSS-induced colitis.	dss	92-95	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	25-28
32447215-11	2020	These results suggest that EP4 stimulation aids in mucosal repair from DSS-induced acute colitis by promoting lymphangiogenesis.	dss	71-74	prostaglandin E receptor 4	Homo sapiens	27-30
32696223-6	2020	We confirmed that the absence of intestinal epithelial HIF-1alpha changed the composition of the intestinal microbes and increased the susceptibility of mice to dextran sodium sulfate (DSS)-induced colitis.	dss	185-188	hypoxia inducible factor 1, alpha subunit	Mus musculus	55-65
32165095-3	2020	Using a cohort of 58 patients from two phase 2 trials, our group previously reported that mutations in the ATM, RB1, and FANCC genes correlate with complete response to cisplatin-based NAC, and consequently improve OS and disease-specific survival (DSS).	dss	249-252	ATM serine/threonine kinase	Homo sapiens	107-110
32165095-3	2020	Using a cohort of 58 patients from two phase 2 trials, our group previously reported that mutations in the ATM, RB1, and FANCC genes correlate with complete response to cisplatin-based NAC, and consequently improve OS and disease-specific survival (DSS).	dss	249-252	RB transcriptional corepressor 1	Homo sapiens	112-115
32165095-3	2020	Using a cohort of 58 patients from two phase 2 trials, our group previously reported that mutations in the ATM, RB1, and FANCC genes correlate with complete response to cisplatin-based NAC, and consequently improve OS and disease-specific survival (DSS).	dss	249-252	FA complementation group C	Homo sapiens	121-126
32165095-5	2020	Updated long-term follow-up (median 74 mo) shows that significantly greater OS and DSS was maintained for patients with ATM, RB1, or FANCC mutations.	dss	83-86	ATM serine/threonine kinase	Homo sapiens	120-123
32165095-5	2020	Updated long-term follow-up (median 74 mo) shows that significantly greater OS and DSS was maintained for patients with ATM, RB1, or FANCC mutations.	dss	83-86	RB transcriptional corepressor 1	Homo sapiens	125-128
32165095-5	2020	Updated long-term follow-up (median 74 mo) shows that significantly greater OS and DSS was maintained for patients with ATM, RB1, or FANCC mutations.	dss	83-86	FA complementation group C	Homo sapiens	133-138
32442901-9	2020	Further, NF-kappaB activation was also blocked by attenuating the phosphorylation of IkB kinase (IKK alpha/beta) in DSS-induced colitis tissues.	dss	116-119	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	9-18
32442901-9	2020	Further, NF-kappaB activation was also blocked by attenuating the phosphorylation of IkB kinase (IKK alpha/beta) in DSS-induced colitis tissues.	dss	116-119	conserved helix-loop-helix ubiquitous kinase	Mus musculus	97-111
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	tumor necrosis factor	Mus musculus	137-164
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	tumor necrosis factor	Mus musculus	166-175
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	interleukin 6	Mus musculus	178-191
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	interleukin 6	Mus musculus	193-197
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	254-257
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	caspase 3	Mus musculus	284-293
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	tight junction protein 1	Mus musculus	360-377
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	tight junction protein 1	Mus musculus	379-383
32281710-5	2020	Furthermore, increased inflammation and apoptosis were observed in the tissues of DSS-induced colitis mice, with increased expression of tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), phosphorylation of nuclear factor kappa B (NF-kappaB)-p65 (p-NF-kB-p65) and cleaved caspase-3, and decreased expression of tight junction (TJ) proteins such as zonula occluden-1 (ZO-1) and occludin.	dss	82-85	occludin	Mus musculus	389-397
32696223-12	2020	Butyrate can alleviate DSS-induced colitis by regulating autophagy via HIF-1alpha.	dss	23-26	hypoxia inducible factor 1, alpha subunit	Mus musculus	71-81
32696223-15	2020	The absence of intestinal epithelial HIF-1alpha exacerbates DSS-induced colitis.	dss	60-63	hypoxia inducible factor 1, alpha subunit	Mus musculus	37-47
32696223-16	2020	Short-chain fatty acids (SCFAs) can alleviate DSS-induced colitis by regulating autophagy via HIF-1alpha.	dss	46-49	hypoxia inducible factor 1, alpha subunit	Mus musculus	94-104
32640223-2	2020	Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.	dss	195-198	colony stimulating factor 2	Homo sapiens	18-66
32329325-7	2020	Results The expressions of IL-6, TNF-alpha, and IL-10, and HCIS in DSS-induced colitis mice were increased compared with control.	dss	67-70	interleukin 6	Mus musculus	27-31
32329325-7	2020	Results The expressions of IL-6, TNF-alpha, and IL-10, and HCIS in DSS-induced colitis mice were increased compared with control.	dss	67-70	tumor necrosis factor	Mus musculus	33-42
32329325-7	2020	Results The expressions of IL-6, TNF-alpha, and IL-10, and HCIS in DSS-induced colitis mice were increased compared with control.	dss	67-70	interleukin 10	Mus musculus	48-53
32684846-7	2020	Increased mRNA expression of ATP1A3 was significantly associated with shorter overall survival (OS) and disease-specific survival (DSS) in patients with OSC, whereas higher expression of ATP1A4 was associated with favorable OS and DSS.	dss	131-134	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	29-35
32684846-8	2020	Multivariate analysis showed that primary therapy outcome, residual tumor, and mRNA expressions of ATP1A3 and ATP1A4 were independent prognostic factors for both OS and DSS in patients with OSC.	dss	169-172	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	99-105
32684846-8	2020	Multivariate analysis showed that primary therapy outcome, residual tumor, and mRNA expressions of ATP1A3 and ATP1A4 were independent prognostic factors for both OS and DSS in patients with OSC.	dss	169-172	ATPase Na+/K+ transporting subunit alpha 4	Homo sapiens	110-116
32684846-10	2020	A high expression of ATP1A3 was significantly correlated with poor OS and DSS in the subgroup of patients aged >= 60 years and with FIGO stage III, histological grade G3, and TP53 mutation.	dss	74-77	ATPase Na+/K+ transporting subunit alpha 3	Homo sapiens	21-27
32650602-9	2020	The increase in content of the proinflammatory enzymes, COX-2 and iNOS induced by DSS were also significantly inhibited by NED along with tissue nitrate levels.	dss	82-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	56-61
32650602-9	2020	The increase in content of the proinflammatory enzymes, COX-2 and iNOS induced by DSS were also significantly inhibited by NED along with tissue nitrate levels.	dss	82-85	inositol-3-phosphate synthase 1	Homo sapiens	66-70
32640223-2	2020	Here, we identify granulocyte-macrophage colony stimulating factor (GM-CSF) as a critical regulator of intestinal macrophage activation in patients with IBD and mice with dextran sodium sulfate (DSS)-induced colitis.	dss	195-198	colony stimulating factor 2	Homo sapiens	68-74
32428800-8	2020	The 5-year DSS of Mt/Wt patients was 95.7 %/95.4 % for stage IA2 (p = 0.684) and 93.2 %/77.5 % for stage IB (p = 0.016).	dss	11-14	protein tyrosine phosphatase receptor type N	Homo sapiens	61-64
32428800-11	2020	CONCLUSION: EGFR mutation had no effect on the prognosis of stage 0-IA NSCLC but significantly affected the OS and DSS of stage IB NSCLC.	dss	115-118	epidermal growth factor receptor	Homo sapiens	12-16
32385106-5	2020	Moreover, the IGF2BP1 deletion aggravated dextran sodium sulfate (DSS)-induced colitis.	dss	66-69	insulin-like growth factor 2 mRNA binding protein 1	Mus musculus	14-21
32386234-11	2020	Trp regulated the DSS-induced immune response partly through attenuating the activation of toll-like receptor 4 (TLR4)-STAT3 signaling and nucleus p-65.	dss	18-21	toll-like receptor 4	Mus musculus	91-111
32386234-11	2020	Trp regulated the DSS-induced immune response partly through attenuating the activation of toll-like receptor 4 (TLR4)-STAT3 signaling and nucleus p-65.	dss	18-21	toll-like receptor 4	Mus musculus	113-117
32386234-11	2020	Trp regulated the DSS-induced immune response partly through attenuating the activation of toll-like receptor 4 (TLR4)-STAT3 signaling and nucleus p-65.	dss	18-21	signal transducer and activator of transcription 3	Mus musculus	119-124
32567429-8	2020	RESULTS: DSS mice showed a significant down-regulation of occludin and claudin-1 compared with controls.	dss	9-12	occludin	Mus musculus	58-66
32517784-0	2020	Modified Pulsatillae decoction inhibits DSS-induced ulcerative colitis in vitro and in vivo via IL-6/STAT3 pathway.	dss	40-43	interleukin 6	Homo sapiens	96-100
32517784-0	2020	Modified Pulsatillae decoction inhibits DSS-induced ulcerative colitis in vitro and in vivo via IL-6/STAT3 pathway.	dss	40-43	signal transducer and activator of transcription 3	Homo sapiens	101-106
32526927-4	2020	Resveratrol treatment in the azoxymethane (AOM) and dextran sodium sulphate (DSS) CRC murine model caused an increase in anti-inflammatory CD4 + FOXP3 + (Tregs) and CD4 + IL10 + cells, a decrease in proinflammatory Th1 and Th17 cells, and attenuated CRC development.	dss	77-80	CD4 antigen	Mus musculus	139-142
32526927-4	2020	Resveratrol treatment in the azoxymethane (AOM) and dextran sodium sulphate (DSS) CRC murine model caused an increase in anti-inflammatory CD4 + FOXP3 + (Tregs) and CD4 + IL10 + cells, a decrease in proinflammatory Th1 and Th17 cells, and attenuated CRC development.	dss	77-80	forkhead box P3	Mus musculus	145-150
32143173-7	2020	Moreover tumors with cytoplasmic expression of B7-H3 tended to have a worse prognosis for disease-specific survival (DSS) than those with membranous expression.	dss	117-120	CD276 molecule	Homo sapiens	47-52
32567429-8	2020	RESULTS: DSS mice showed a significant down-regulation of occludin and claudin-1 compared with controls.	dss	9-12	claudin 1	Mus musculus	71-80
32429318-8	2020	In contrast, positive CCL2 staining in the ICs was associated with longer OS, DSS, and RFS (p = 0.032, p = 0.001, and p = 0.001; log rank test) and appeared to be an independent prognostic factor for DSS (RR = 1.77; p = 0.031; multivariate Cox"s regression analysis).	dss	78-81	C-C motif chemokine ligand 2	Homo sapiens	22-26
32194081-16	2020	EZH2 expression was up-regulated but ANGPTL4 and CREB1 expression were down-regulated in DSS-treated mice.	dss	89-92	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	0-4
32194081-16	2020	EZH2 expression was up-regulated but ANGPTL4 and CREB1 expression were down-regulated in DSS-treated mice.	dss	89-92	angiopoietin-like 4	Mus musculus	37-44
32194081-16	2020	EZH2 expression was up-regulated but ANGPTL4 and CREB1 expression were down-regulated in DSS-treated mice.	dss	89-92	cAMP responsive element binding protein 1	Mus musculus	49-54
32382338-6	2020	Furthermore, higher ID-1 expression levels were associated with a shorter DSS time.	dss	74-77	inhibitor of DNA binding 1, HLH protein	Homo sapiens	20-24
32382338-7	2020	Taken together, the results of the present study suggest that ID-1 may serve as an independent prognostic factor to predict DSS time in patients with OSCC.	dss	124-127	inhibitor of DNA binding 1, HLH protein	Homo sapiens	62-66
32485960-5	2020	In the AOM/DSS-induced colitis-associated cancer model, the intraperitoneal transplantation of TRAIL-expressing ASCs significantly suppressed colon cancer development.	dss	11-14	TNF superfamily member 10	Homo sapiens	95-100
32485960-6	2020	Moreover, immunohistochemical staining revealed a low CD133 expression in tumors from the AOM/DSS + ASCs group when compared with tumors from the untreated group.	dss	94-97	prominin 1	Homo sapiens	54-59
32429425-6	2020	The basal DSS group had reduced growth, higher pathology score and an increased expression of MMP1, IL13 and IL23 compared with the controls (p < 0.05); these parameters were similar between the DSS-challenged groups (p > 0.05).	dss	10-13	interstitial collagenase	Sus scrofa	94-98
32429425-6	2020	The basal DSS group had reduced growth, higher pathology score and an increased expression of MMP1, IL13 and IL23 compared with the controls (p < 0.05); these parameters were similar between the DSS-challenged groups (p > 0.05).	dss	10-13	interleukin 13	Sus scrofa	100-104
32429425-6	2020	The basal DSS group had reduced growth, higher pathology score and an increased expression of MMP1, IL13 and IL23 compared with the controls (p < 0.05); these parameters were similar between the DSS-challenged groups (p > 0.05).	dss	10-13	IL-23	Sus scrofa	109-113
32331643-9	2020	At the end of treatments, among the DSS-induced groups, G3 exhibited the lowest BW losses (11.5%), MPO activity (10.4%) and beta-GLUC (8.6%).	dss	36-39	myeloperoxidase	Mus musculus	99-102
32331643-15	2020	In conclusion, CBS consumption decreased the inflammatory state and reduced the expression of the IL-1 receptor, TLR, and TNF-alpha-associated pathways in DSS-induced UC in CD-1 mice.	dss	155-158	tumor necrosis factor	Mus musculus	122-131
32331643-15	2020	In conclusion, CBS consumption decreased the inflammatory state and reduced the expression of the IL-1 receptor, TLR, and TNF-alpha-associated pathways in DSS-induced UC in CD-1 mice.	dss	155-158	CD1 antigen complex	Mus musculus	173-177
32486441-5	2020	Additionally, DHA:EPA (1:2, 10 microM) combination decreased the apoptotic caspase-3/7 activity around twofold after 24 h LPS and DSS challenge (p < 0.05).	dss	130-133	caspase 3	Sus scrofa	75-86
32523538-10	2020	DSS animals benefited from treatment with the sGC activator, as Fpassive, titin phosphorylation, PKG and the hypertrophic pathway kinases, pro-inflammatory cytokines, and oxidative stress markers all significantly improved to the level observed in controls.	dss	0-3	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	46-49
32523538-10	2020	DSS animals benefited from treatment with the sGC activator, as Fpassive, titin phosphorylation, PKG and the hypertrophic pathway kinases, pro-inflammatory cytokines, and oxidative stress markers all significantly improved to the level observed in controls.	dss	0-3	titin	Homo sapiens	74-79
32523538-10	2020	DSS animals benefited from treatment with the sGC activator, as Fpassive, titin phosphorylation, PKG and the hypertrophic pathway kinases, pro-inflammatory cytokines, and oxidative stress markers all significantly improved to the level observed in controls.	dss	0-3	protein kinase cGMP-dependent 1	Homo sapiens	97-100
32523538-11	2020	Immunohistochemistry and electron microscopy revealed a translocation of sGC protein toward the intercalated disc and t-tubuli following treatment in both control and DSS samples.	dss	167-170	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	73-76
32523538-13	2020	DSS rats showed a disrupted connexin 43 pattern, and sGC activator was able to partially reduce disruption and increase expression of connexin 43.	dss	0-3	gap junction protein, alpha 1	Rattus norvegicus	28-39
32523538-13	2020	DSS rats showed a disrupted connexin 43 pattern, and sGC activator was able to partially reduce disruption and increase expression of connexin 43.	dss	0-3	gap junction protein, alpha 1	Rattus norvegicus	134-145
32429318-8	2020	In contrast, positive CCL2 staining in the ICs was associated with longer OS, DSS, and RFS (p = 0.032, p = 0.001, and p = 0.001; log rank test) and appeared to be an independent prognostic factor for DSS (RR = 1.77; p = 0.031; multivariate Cox"s regression analysis).	dss	200-203	C-C motif chemokine ligand 2	Homo sapiens	22-26
32477115-4	2020	We further revealed that vidofludimus exerts in vivo therapeutic effects on dextran sodium sulfate (DSS)-induced colitis in an FXR-dependent manner.	dss	100-103	nuclear receptor subfamily 1 group H member 4	Homo sapiens	127-130
32386518-10	2020	CONCLUSION: miR-330-3p is upregulated by DSS in both HT-29 cells and mice and promoted ulcerative colitis and cell apoptosis by targeting of 3"-UTR of XBP1, which is a key component of ER stress.	dss	41-44	X-box binding protein 1	Mus musculus	151-155
32934875-8	2020	MMP2 (p = .001) and extra-nodal extension (ENE) (p = .006) were independent biomarkers of disease-specific survival (DSS) in multivariate analysis and defined prognostic groups with 5-year DSS ranging from 36% (MMP2highENE+) to 88% (MMP2lowENE-).	dss	117-120	matrix metallopeptidase 2	Homo sapiens	0-4
32316726-7	2020	HPSB significantly reduced the levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) induced by HFD+DSS in mice.	dss	124-127	interleukin 6	Mus musculus	41-54
32316726-7	2020	HPSB significantly reduced the levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) induced by HFD+DSS in mice.	dss	124-127	interleukin 6	Mus musculus	56-60
32316726-7	2020	HPSB significantly reduced the levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) induced by HFD+DSS in mice.	dss	124-127	chemokine (C-C motif) ligand 2	Mus musculus	66-100
32316726-7	2020	HPSB significantly reduced the levels of interleukin-6 (IL-6) and monocyte chemoattractant protein-1 (MCP-1) induced by HFD+DSS in mice.	dss	124-127	chemokine (C-C motif) ligand 2	Mus musculus	102-107
32386518-11	2020	Inhibition of miR-330-3p prevent DSS-induced ulcerative colitis and cell apoptosis mediated by upregulation of XBP1 expression.	dss	33-36	microRNA 330	Mus musculus	14-21
32386518-0	2020	Suppression of miR-330-3p alleviates DSS-induced ulcerative colitis and apoptosis by upregulating the endoplasmic reticulum stress components XBP1.	dss	37-40	microRNA 330	Mus musculus	15-22
32386518-0	2020	Suppression of miR-330-3p alleviates DSS-induced ulcerative colitis and apoptosis by upregulating the endoplasmic reticulum stress components XBP1.	dss	37-40	X-box binding protein 1	Mus musculus	142-146
32411291-0	2020	Huanglian Jiedu Decoction ameliorates DSS-induced colitis in mice via the JAK2/STAT3 signalling pathway.	dss	38-41	Janus kinase 2	Mus musculus	74-78
32411291-0	2020	Huanglian Jiedu Decoction ameliorates DSS-induced colitis in mice via the JAK2/STAT3 signalling pathway.	dss	38-41	signal transducer and activator of transcription 3	Mus musculus	79-84
32411291-2	2020	In this paper, the effect of Huanglian Jiedu Decoction (HJD), a well-known traditional Chinese medicine with significant anti-inflammatory effect, on dextran sulphate sodium (DSS)-induced UC in mice and inhibition of JAK2/STAT3 pathway were investigated.	dss	175-178	Janus kinase 2	Mus musculus	217-221
32411291-2	2020	In this paper, the effect of Huanglian Jiedu Decoction (HJD), a well-known traditional Chinese medicine with significant anti-inflammatory effect, on dextran sulphate sodium (DSS)-induced UC in mice and inhibition of JAK2/STAT3 pathway were investigated.	dss	175-178	signal transducer and activator of transcription 3	Mus musculus	222-227
32477332-3	2020	While CSR to IgG1 is abolished in mice lacking an Igamma1 exon donor splice site (dss), many questions remain regarding the importance of I exon dss recognition in CSR.	dss	82-85	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	13-17
32477332-9	2020	Altogether, this study reveals that the recognition of I exon dss first supports RNA pol II pausing and the opening of chromatin in targeted S regions and that GLT splicing events using constitutive I exon dss appear mandatory for the later steps of CSR, most likely by guiding AID to S regions.	dss	62-65	activation-induced cytidine deaminase	Mus musculus	278-281
32477332-9	2020	Altogether, this study reveals that the recognition of I exon dss first supports RNA pol II pausing and the opening of chromatin in targeted S regions and that GLT splicing events using constitutive I exon dss appear mandatory for the later steps of CSR, most likely by guiding AID to S regions.	dss	206-209	activation-induced cytidine deaminase	Mus musculus	278-281
32386518-11	2020	Inhibition of miR-330-3p prevent DSS-induced ulcerative colitis and cell apoptosis mediated by upregulation of XBP1 expression.	dss	33-36	X-box binding protein 1	Mus musculus	111-115
32398956-0	2020	Slit2/Robo1 Mitigates DSS-induced Ulcerative Colitis by Activating Autophagy in Intestinal Stem Cell.	dss	22-25	slit guidance ligand 2	Mus musculus	0-5
32058214-10	2020	Moreover, SH administration alleviated the oxidative stress in the colon of DSS-induced colitis mice, evidenced by the decrease of myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, and increase of ROS level.	dss	76-79	myeloperoxidase	Mus musculus	131-146
32058214-10	2020	Moreover, SH administration alleviated the oxidative stress in the colon of DSS-induced colitis mice, evidenced by the decrease of myeloperoxidase (MPO) activity and malondialdehyde (MDA) level, and increase of ROS level.	dss	76-79	myeloperoxidase	Mus musculus	148-151
32232697-6	2020	The significance of MAI > 12/Her2negative seems to be limited to women <= 55 years for both DMFS and DSS.	dss	101-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-33
32232697-9	2020	CONCLUSION: The MAI > 12/Her2negative combination seems to be a strong prognosticator for DMFS and DSS, particularly for women <= 55 years.	dss	99-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-29
30251569-7	2020	More women randomized to GPC reported composite positive peer support on the DSS (52.5 versus 26.3%; p < .02).	dss	77-80	glycophorin C (Gerbich blood group)	Homo sapiens	25-28
32029576-6	2020	Bone marrow-chimeric mice with genetic depletion of the H4R in nonhematopoietic cells exhibited less severe DSS-induced acute colitis symptoms compared with WT mice, indicating a functional proinflammatory expression of H4R in nonimmune cells of the colon.	dss	108-111	histamine receptor H4	Mus musculus	56-59
32029576-9	2020	Thus, we conclude that the H4R is functionally expressed in mouse colon epithelial cells, potentially modulating mucosal barrier integrity and intestinal inflammatory reactions, as was demonstrated in the DSS-induced colitis model, in which presence of the H4R on nonhematopoietic cells aggravated the inflammatory phenotype.	dss	205-208	histamine receptor H4	Mus musculus	27-30
32366032-7	2020	A lack of dietary AhR ligands caused enhanced susceptibility to dextran sodium sulfate (DSS)-induced colitis and correlated with the expansion of Enterobacteriaceae, whereas Clostridiales, Muribaculaceae, and Rikenellaceae were strongly reduced.	dss	88-91	aryl-hydrocarbon receptor	Mus musculus	18-21
32432037-14	2020	In multivariate analyses, TLE1 expression was independently associated with DSS in all patients and four patient subgroups.	dss	76-79	TLE family member 1, transcriptional corepressor	Homo sapiens	26-30
32010961-4	2020	We find that variant burden in ABCC1 is a strong predictor of DSS in BRCA patients, whereas candidate polymorphisms are not associated with DSS.	dss	62-65	ATP binding cassette subfamily C member 1	Homo sapiens	31-36
32087149-3	2020	Compared to MSCs without treatment, MSCs infected with a lentivirus (LV) encoding CX3CR1 and IL-25 (CX3CR1&amp;IL-25-LV-MSCs) exhibited enhanced targeting to the inflamed colon and could further move into extravascular space of the colon tissues via trans-endothelial migration in dextran sodium sulfate (DSS)-challenged mice after MSC intravenous injection.	dss	305-308	chemokine (C-X3-C motif) receptor 1	Mus musculus	82-88
32087149-3	2020	Compared to MSCs without treatment, MSCs infected with a lentivirus (LV) encoding CX3CR1 and IL-25 (CX3CR1&amp;IL-25-LV-MSCs) exhibited enhanced targeting to the inflamed colon and could further move into extravascular space of the colon tissues via trans-endothelial migration in dextran sodium sulfate (DSS)-challenged mice after MSC intravenous injection.	dss	305-308	interleukin 25	Mus musculus	93-98
32087149-3	2020	Compared to MSCs without treatment, MSCs infected with a lentivirus (LV) encoding CX3CR1 and IL-25 (CX3CR1&amp;IL-25-LV-MSCs) exhibited enhanced targeting to the inflamed colon and could further move into extravascular space of the colon tissues via trans-endothelial migration in dextran sodium sulfate (DSS)-challenged mice after MSC intravenous injection.	dss	305-308	chemokine (C-X3-C motif) receptor 1	Mus musculus	100-106
32087149-3	2020	Compared to MSCs without treatment, MSCs infected with a lentivirus (LV) encoding CX3CR1 and IL-25 (CX3CR1&amp;IL-25-LV-MSCs) exhibited enhanced targeting to the inflamed colon and could further move into extravascular space of the colon tissues via trans-endothelial migration in dextran sodium sulfate (DSS)-challenged mice after MSC intravenous injection.	dss	305-308	interleukin 25	Mus musculus	111-116
32398956-0	2020	Slit2/Robo1 Mitigates DSS-induced Ulcerative Colitis by Activating Autophagy in Intestinal Stem Cell.	dss	22-25	roundabout guidance receptor 1	Mus musculus	6-11
32398956-7	2020	Slit2-Tg DSS mice showed less body weight loss, less blood in the stool, and less viscous stool compared to those of WTSlit DSS mice.	dss	9-12	slit guidance ligand 2	Mus musculus	0-5
32398956-7	2020	Slit2-Tg DSS mice showed less body weight loss, less blood in the stool, and less viscous stool compared to those of WTSlit DSS mice.	dss	124-127	slit guidance ligand 2	Mus musculus	0-5
32398956-8	2020	Robo1/2+/- DSS mice displayed a heavier degree of blood in the stool and a more apparent viscosity of the stool compared to those of WTRobo1/2 DSS mice.	dss	11-14	roundabout guidance receptor 1	Mus musculus	0-7
32398956-9	2020	Slit2 overexpression maintained Lgr5+ stem cell proliferation in the crypt after DSS treatment, significantly increased the LC3II/I ratio, and slightly stimulated p62 expression in the crypt compared to those of DSS-induced WTSlit mice.	dss	81-84	slit guidance ligand 2	Mus musculus	0-5
32398956-10	2020	Robo1/2 partial knockout reduced the number of Lgr5+ stem cells, decreased the LC3II/I ratio, and markedly increased p62 expression in the crypt compare to those of DSS-treated WTRobo1/2 mice.	dss	165-168	roundabout guidance receptor 1	Mus musculus	0-7
32276475-4	2020	Here, we analyzed whether H4R is involved in the pathogenesis of AOM/DSS-induced CRC in mice.	dss	69-72	histamine receptor H4	Mus musculus	26-29
32398956-11	2020	Our findings suggest that Slit2/Robo1 mediates DSS-induced UC probably by activating the autophagy of Lgr5+ stem cells.	dss	47-50	slit guidance ligand 2	Mus musculus	26-31
32276475-5	2020	As compared to wild type (WT) mice, AOM/DSS-treated mice lacking H4R expression (TM) demonstrate ameliorated signs of CRC, i.e., significantly reduced loss of body weight, stiffer stool consistency, and less severe perianal bleeding.	dss	40-43	histamine receptor H4	Mus musculus	65-68
32398956-11	2020	Our findings suggest that Slit2/Robo1 mediates DSS-induced UC probably by activating the autophagy of Lgr5+ stem cells.	dss	47-50	roundabout guidance receptor 1	Mus musculus	32-37
32398956-11	2020	Our findings suggest that Slit2/Robo1 mediates DSS-induced UC probably by activating the autophagy of Lgr5+ stem cells.	dss	47-50	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	102-106
32218552-0	2020	Dairy Propionibacterium freudenreichii ameliorates acute colitis by stimulating MUC2 expression in intestinal goblet cell in a DSS-induced colitis rat model.	dss	127-130	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	80-84
32218552-8	2020	The SPFC and LPF treatments increased the gene and protein expression levels of MUC2 in the rats with DSS-induced colitis compared with the expression levels in the negative control rats, and immunohistochemistry (IHC) showed an increase of the intestinal MUC2 level.	dss	102-105	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	80-84
32218552-8	2020	The SPFC and LPF treatments increased the gene and protein expression levels of MUC2 in the rats with DSS-induced colitis compared with the expression levels in the negative control rats, and immunohistochemistry (IHC) showed an increase of the intestinal MUC2 level.	dss	102-105	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	256-260
32184453-4	2020	The nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 (NLRP3) inflammasome was more strongly upregulated in colon tissues of Slco2a-/- mice administered DSS and in macrophages isolated from Slco2a1-/- mice than in the WT counterparts.	dss	196-199	interferon activated gene 208	Mus musculus	71-96
32184453-4	2020	The nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 (NLRP3) inflammasome was more strongly upregulated in colon tissues of Slco2a-/- mice administered DSS and in macrophages isolated from Slco2a1-/- mice than in the WT counterparts.	dss	196-199	NLR family, pyrin domain containing 3	Mus musculus	98-103
32184453-4	2020	The nucleotide-binding domain, leucine-rich repeats containing family, pyrin domain-containing-3 (NLRP3) inflammasome was more strongly upregulated in colon tissues of Slco2a-/- mice administered DSS and in macrophages isolated from Slco2a1-/- mice than in the WT counterparts.	dss	196-199	solute carrier organic anion transporter family, member 2a1	Mus musculus	233-240
32184453-5	2020	Slco2a1DeltaMP, but not Slco2a1DeltaIEC mice, were more susceptible to DSS-induced colitis than WT mice, partly phenocopying Slco2a-/- mice.	dss	71-74	solute carrier organic anion transporter family, member 2a1	Mus musculus	0-7
32214798-6	2020	Results: We found that miR-370-3p significantly improved the body weights and survival rates and inhibited the tumorigenesis of UC-CRC in AOM/DSS mice.	dss	142-145	microRNA 370	Mus musculus	23-30
32214798-8	2020	miR-370-3p decreased the expression of tumor-associated proteins, including p53, beta-catenin, and ki67 in AOM/DSS-treated mice.	dss	111-114	transformation related protein 53, pseudogene	Mus musculus	76-79
32214798-8	2020	miR-370-3p decreased the expression of tumor-associated proteins, including p53, beta-catenin, and ki67 in AOM/DSS-treated mice.	dss	111-114	catenin (cadherin associated protein), beta 1	Mus musculus	81-93
31987131-7	2020	We generated recombinant MMP1 protein and anti-peptide antibodies against MMP1, which were used to optimize the procedures of the entire workflow, including DSS sampling, on-paper protein digestion and elution, KingFisher magnetic particle processor-assisted immuno-enrichment and MALDI-TOF MS analysis.	dss	157-160	matrix metallopeptidase 1	Homo sapiens	25-29
31913697-5	2020	Considering this possibility, we first explored if colitis regulated Olfr-78 expression in the gut, where we observed a significant reduction in the expression of Olfr-78 transcript in mouse models of dextran sodium sulfate (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis.	dss	225-228	olfactory receptor family 51 subfamily E member 2	Mus musculus	69-76
31987131-7	2020	We generated recombinant MMP1 protein and anti-peptide antibodies against MMP1, which were used to optimize the procedures of the entire workflow, including DSS sampling, on-paper protein digestion and elution, KingFisher magnetic particle processor-assisted immuno-enrichment and MALDI-TOF MS analysis.	dss	157-160	matrix metallopeptidase 1	Homo sapiens	74-78
31913697-5	2020	Considering this possibility, we first explored if colitis regulated Olfr-78 expression in the gut, where we observed a significant reduction in the expression of Olfr-78 transcript in mouse models of dextran sodium sulfate (DSS)- and 2,4,6-trinitrobenzenesulfonic acid (TNBS)-induced colitis.	dss	225-228	olfactory receptor family 51 subfamily E member 2	Mus musculus	163-170
31987131-8	2020	The established workflow was applied to measure salivary MMP1 levels in DSS samples from 5 healthy donors and 9 OSCC cases.	dss	72-75	matrix metallopeptidase 1	Homo sapiens	57-61
31913697-6	2020	To more directly test this, mice deficient in Olfr-78 were administered with DSS in water for 7 days and were found to have increased expression of IL-1beta and inflammatory signs in colon compared with control mice.	dss	77-80	olfactory receptor family 51 subfamily E member 2	Mus musculus	46-53
31913697-6	2020	To more directly test this, mice deficient in Olfr-78 were administered with DSS in water for 7 days and were found to have increased expression of IL-1beta and inflammatory signs in colon compared with control mice.	dss	77-80	interleukin 1 alpha	Mus musculus	148-156
31987131-9	2020	The newly developed workflow showed good precision (intra-day and inter-day variations <10%) and accuracy (80-100%) in quantification of MMP1 in DSS samples, with the limit of quantification at 3.07 ng/ml.	dss	145-148	matrix metallopeptidase 1	Homo sapiens	137-141
31913697-9	2020	Collectively, our findings show that Olfr-78 is highly expressed in colon and downregulated in DSS- and TNBS-induced colitis, and DSS-treated Olfr-78 null mice had increased colonic expression of cytokine RNA levels, suggesting a potential role for this receptor in intestinal inflammation.	dss	95-98	olfactory receptor family 51 subfamily E member 2	Mus musculus	37-44
31931369-6	2020	Avertin upregulated MPO production and induced the accumulation of neutrophils and macrophages in intestinal mucosa of both WT and DSS-treated mice; the altered MPO might indicate a change in respiratory burst.	dss	131-134	myeloperoxidase	Mus musculus	161-164
31913697-9	2020	Collectively, our findings show that Olfr-78 is highly expressed in colon and downregulated in DSS- and TNBS-induced colitis, and DSS-treated Olfr-78 null mice had increased colonic expression of cytokine RNA levels, suggesting a potential role for this receptor in intestinal inflammation.	dss	130-133	olfactory receptor family 51 subfamily E member 2	Mus musculus	142-149
32207275-9	2020	DSS curves between stages on TNM-8 (P<0.001) and modified-TNM (P<0.001) differed significantly, but the modified-TNM discriminated better than TNM-8.	dss	0-3	teneurin transmembrane protein 1	Homo sapiens	29-32
32207275-11	2020	CONCLUSION: Modification of the TNM staging system focusing on ETE and N1b could improve the prediction of DSS in patients with DTC.	dss	107-110	teneurin transmembrane protein 1	Homo sapiens	32-35
31535245-7	2020	Importantly, the CUL4A status was identified as an independent prognostic factor for DSS (P = 0.045).	dss	85-88	cullin 4A	Homo sapiens	17-22
32207275-7	2020	The 10-year disease-specific survival (DSS) rates in patients classified as stages I, II, III, and IV by TNM-8 were 99.8%, 95.9%, 81.0%, and 41.6%, respectively.	dss	39-42	teneurin transmembrane protein 1	Homo sapiens	105-108
32207275-8	2020	The DSS rates of patients classified as stages I, IIA, IIB, III, and IV according to the modified-TNM were 99.8%, 96.4%, 93.3%, 81.0%, and 41.6%, respectively.	dss	4-7	teneurin transmembrane protein 1	Homo sapiens	98-101
31535245-6	2020	The disease-specific survival (DSS) rate in patients with tumors that showed high CUL4A expression levels was significantly lower than that in patients whose tumors showed low CUL4A expression levels (P = 0.001).	dss	31-34	cullin 4A	Homo sapiens	82-87
31077407-13	2020	The presence of nodal and distant metastases at diagnosis are negative prognostic factors in OS and DSS.	dss	100-103	nodal growth differentiation factor	Homo sapiens	16-21
32185195-5	2020	The high TXLNA expression was significantly correlated with superior overall survival (OS), disease-free interval (DFI), disease specific survival (DSS), and progression-free interval (PFI) for PAAD patients.	dss	148-151	taxilin alpha	Homo sapiens	9-14
31614203-8	2020	Furthermore, pharmacological inhibition of PXR was further evaluated by examining PA protection against DSS-induced colitis.	dss	104-107	nuclear receptor subfamily 1 group I member 2	Homo sapiens	43-46
32185195-6	2020	In summary, high TXLNA expression could predict favourable OS, DFI, DSS, and PFI for PAAD patients, and it might be as potential prognostic biomarkers and targets for PAAD.	dss	68-71	taxilin alpha	Homo sapiens	17-22
31614203-12	2020	PA prevented DSS-induced inflammation by regulating PXR/NF-kappaB signalling, whereas pharmacological PXR inhibition abated PA-mediated suppressive effects on NF-kappaB inflammation signalling.	dss	13-16	nuclear receptor subfamily 1 group I member 2	Homo sapiens	52-55
31916636-4	2020	We intrarectally or intraperitoneally delivered Gstt1 gene to mice with dextran sodium sulfate (DSS)-induced colitis and noted attenuation of colitis through gene transfer of Gstt1 via an IL-22 dependent pathway.	dss	96-99	glutathione S-transferase, theta 1	Mus musculus	48-53
31964918-5	2020	DSS and gut-microbiota alteration induced high serum anti-dsDNA immunoglobulin (Ig) as early as 30 days post-DSS only in FcGRIIb-/- mice.	dss	0-3	Fc receptor, IgG, low affinity IIb	Mus musculus	121-128
32082998-10	2020	Moreover, pooled analysis illustrated that elevated NLR and CRP represents poor DSS, with HRs of 1.46 and 2.06, respectively.	dss	80-83	C-reactive protein	Homo sapiens	60-63
31825438-0	2020	FSGHF3 and peptides, prepared from fish skin gelatin, exert a protective effect on DSS-induced colitis via the Nrf2 pathway.	dss	83-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	111-115
31964918-8	2020	However, DSS induced spleen apoptosis in FcGRIIb-/- and WT mice at 30 and 60 days post-DSS, respectively, suggesting the higher impact of gut-leakage against spleen of lupus mice.	dss	9-12	Fc receptor, IgG, low affinity IIb	Mus musculus	41-48
31643033-5	2020	RESULTS: DSS challenge damaged the murine colonic architecture, reduced the MUC2 mucin and the tight-junction protein ZO-1.	dss	9-12	mucin 2	Mus musculus	76-80
31980634-6	2020	Additionally, Erdr1 accelerates scratch-wound closure in vitro, increases Lgr5+ intestinal stem cell regeneration following radiation-induced injury in vivo, and enhances recovery from dextran sodium sulfate (DSS)-induced colonic damage.	dss	209-212	erythroid differentiation regulator 1	Mus musculus	14-19
32115503-12	2020	In conclusions, resveratrol alleviates DSS-induced IBD by modulating SUMO1 through Wnt/beta-catenin pathway.	dss	39-42	small ubiquitin like modifier 1	Homo sapiens	69-74
32115503-12	2020	In conclusions, resveratrol alleviates DSS-induced IBD by modulating SUMO1 through Wnt/beta-catenin pathway.	dss	39-42	catenin beta 1	Homo sapiens	87-99
31968666-4	2020	In the present study, an SPG-antisense TNF-alpha complex was prepared, and its therapeutic efficacy was examined using a dextran sodium sulfate (DSS)-induced colitis model.	dss	145-148	tumor necrosis factor	Homo sapiens	39-48
31968666-5	2020	The TNF-alpha production in CD11b+ macrophages significantly increased in the colon of DSS-treated mice.	dss	87-90	tumor necrosis factor	Mus musculus	4-13
31968666-5	2020	The TNF-alpha production in CD11b+ macrophages significantly increased in the colon of DSS-treated mice.	dss	87-90	integrin alpha M	Mus musculus	28-33
31968666-7	2020	The expression of dectin-1 by CD11b+ macrophages significantly increased in DSS-treated mice.	dss	76-79	C-type lectin domain family 7, member a	Mus musculus	18-26
31968666-7	2020	The expression of dectin-1 by CD11b+ macrophages significantly increased in DSS-treated mice.	dss	76-79	integrin alpha M	Mus musculus	30-35
32298841-6	2020	RESULTS: Analysis of colonic tissue from mice with DSS-colitis revealed increased mRNA for molecules associated with mitochondrial fission (i.e. Drp1, Fis1) and fusion (optic atrophy factor 1), and increased phospho-Drp1 compared to control.	dss	51-54	dynamin 1-like	Mus musculus	145-149
32298841-6	2020	RESULTS: Analysis of colonic tissue from mice with DSS-colitis revealed increased mRNA for molecules associated with mitochondrial fission (i.e. Drp1, Fis1) and fusion (optic atrophy factor 1), and increased phospho-Drp1 compared to control.	dss	51-54	fission, mitochondrial 1	Mus musculus	151-155
32298841-6	2020	RESULTS: Analysis of colonic tissue from mice with DSS-colitis revealed increased mRNA for molecules associated with mitochondrial fission (i.e. Drp1, Fis1) and fusion (optic atrophy factor 1), and increased phospho-Drp1 compared to control.	dss	51-54	dynamin 1-like	Mus musculus	216-220
31643033-5	2020	RESULTS: DSS challenge damaged the murine colonic architecture, reduced the MUC2 mucin and the tight-junction protein ZO-1.	dss	9-12	tight junction protein 1	Mus musculus	118-122
31628426-5	2020	In mouse models of colitis based on Interleukin-10 deficiency or dextran sodium sulfate (DSS) exposure, we found that IEC-intrinsic RABGEF1 deficiency exacerbated development of intestinal pathology and dysregulated IEC innate pathways and chemokine expression.	dss	89-92	RAB guanine nucleotide exchange factor (GEF) 1	Mus musculus	132-139
31414270-12	2020	CONCLUSIONS: TNM-8 staged a significant number of Chinese patients into lower stages and improved the accuracy of predicting DSS compared with TNM-7.	dss	125-128	teneurin transmembrane protein 1	Homo sapiens	13-16
31448510-9	2020	Platelet P-selectin expression and regulated on activation, normal T-cell expressed and secreted (RANTES) plasma levels were lower in DSS-treated P2X1-deficient mice as compared to wild-type mice, indicative of a platelet secretion defect.	dss	134-137	selectin, platelet	Mus musculus	9-19
31448510-9	2020	Platelet P-selectin expression and regulated on activation, normal T-cell expressed and secreted (RANTES) plasma levels were lower in DSS-treated P2X1-deficient mice as compared to wild-type mice, indicative of a platelet secretion defect.	dss	134-137	chemokine (C-C motif) ligand 5	Mus musculus	98-104
32408308-8	2020	In the survival analysis, high EREG expression was significantly associated with better DSS (p < 0.0001), LRFS (p = 0.0004), and MeFS (p < 0.0001).	dss	88-91	epiregulin	Homo sapiens	31-35
32810863-6	2020	A worse DSS was found in patients who had preoperative CRP >0.5 mg/dL (p = 0.002) and in those with NLR >3.5 (p < 0.001).	dss	8-11	C-reactive protein	Homo sapiens	55-58
32810863-7	2020	In multivariate analysis, tumor size and grade as well as preoperative CRP values and NLR were confirmed to be prognostic factors in terms of DSS.	dss	142-145	C-reactive protein	Homo sapiens	71-74
32408308-9	2020	In the multivariate analysis, high EREG expression remained prognostically significant for better DSS (p = 0.003; hazard ratio: 5.599).	dss	98-101	epiregulin	Homo sapiens	35-39
33132270-8	2020	Furthermore, nitration of src homology protein tyrosine phosphatase 2 in macrophages might be involved in the activation of Toll-like receptor 4 and NF-kappaB, inducing infiltration of activated neutrophils into colonic mucosa to produce ROS in DSS-induced colitis mice.	dss	245-248	Rous sarcoma oncogene	Mus musculus	26-29
33132270-8	2020	Furthermore, nitration of src homology protein tyrosine phosphatase 2 in macrophages might be involved in the activation of Toll-like receptor 4 and NF-kappaB, inducing infiltration of activated neutrophils into colonic mucosa to produce ROS in DSS-induced colitis mice.	dss	245-248	toll-like receptor 4	Mus musculus	124-144
33132270-8	2020	Furthermore, nitration of src homology protein tyrosine phosphatase 2 in macrophages might be involved in the activation of Toll-like receptor 4 and NF-kappaB, inducing infiltration of activated neutrophils into colonic mucosa to produce ROS in DSS-induced colitis mice.	dss	245-248	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	149-158
31472940-9	2019	Regarding DSS, pooled HR were 5.052 and 2.133 for p53mt group, 1.965 and 1.068 for MSI group, and 0.552 and 0.325 for POLEmt group at univariable and multivariable analyses, respectively.	dss	10-13	tumor protein p53	Homo sapiens	50-53
31335355-13	2019	Abnormal p53 status was associated with advanced Federation of Gynecology and Obstetrics stage, lymph node metastases, DFS and DSS (P<0.05, Fisher exact test).	dss	127-130	tumor protein p53	Homo sapiens	9-12
31756977-4	2019	We found that weekly oral administration of CTB-KDEL, dosed before or after the onset of chronic colitis, induced by repeated dextran sodium sulfate (DSS) exposure, could significantly reduce disease activity index scores, intestinal permeability, inflammation, and histological signs of chronicity.	dss	150-153	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	44-47
31773687-11	2019	Notably, SHMT2 expression was an independent prognostic factor for RFS and DSS in GC, ESCC, and CC (p<0.05).	dss	75-78	serine hydroxymethyltransferase 2	Homo sapiens	9-14
30019121-8	2020	Elevated Robo1 nuclear staining was associated with better disease-specific survival (DSS) (p = 0.045).	dss	86-89	roundabout guidance receptor 1	Homo sapiens	9-14
30019121-9	2020	Similarly, stronger Robo4 nuclear staining tended to be associated with longer DSS (p = 0.061).	dss	79-82	roundabout guidance receptor 4	Homo sapiens	20-25
30019121-11	2020	High Slit2 gene expression was correlated with significantly shorter DSS (p &lt; 0.005), while Robo1 and Robo4 gene expressions were not associated with patients" prognosis.	dss	69-72	slit guidance ligand 2	Homo sapiens	5-10
31795962-10	2019	In addition, CAIX expression was associated with DFS and DSS (p = 0.005 and p = 0.012, respectively).	dss	57-60	carbonic anhydrase 9	Homo sapiens	13-17
31795962-11	2019	CONCLUSIONS: CAIX expression was a predictor of pCR and was associated with higher DFS and DSS in locally advanced breast cancer patients subjected to NAC.	dss	91-94	carbonic anhydrase 9	Homo sapiens	13-17
32257220-11	2020	Results: The expression of MGP was significantly increased in colonic tissues from UC patients and DSS-induced colitis models, and was positively correlated with disease severity.	dss	99-102	matrix Gla protein	Homo sapiens	27-30
32239858-11	2019	(2) Compared with normal control group, the expression of miR-31 in colonic tissue of DSS group was increased significantly(P<0.01), compared with DSS group, the expression of miR-31 was decreased after treatment with NC(P< 0.05).	dss	86-89	microRNA 31	Mus musculus	58-64
32239858-11	2019	(2) Compared with normal control group, the expression of miR-31 in colonic tissue of DSS group was increased significantly(P<0.01), compared with DSS group, the expression of miR-31 was decreased after treatment with NC(P< 0.05).	dss	86-89	microRNA 31	Mus musculus	176-182
32239858-11	2019	(2) Compared with normal control group, the expression of miR-31 in colonic tissue of DSS group was increased significantly(P<0.01), compared with DSS group, the expression of miR-31 was decreased after treatment with NC(P< 0.05).	dss	147-150	microRNA 31	Mus musculus	176-182
32239858-12	2019	(3) Compared with DSS group, the levels of inflammatory protein NF-kappaB and COX-2 in DSS + NC group was decreased significantly (P<0.05).	dss	18-21	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
32239858-12	2019	(3) Compared with DSS group, the levels of inflammatory protein NF-kappaB and COX-2 in DSS + NC group was decreased significantly (P<0.05).	dss	18-21	cytochrome c oxidase II, mitochondrial	Mus musculus	78-83
32239858-12	2019	(3) Compared with DSS group, the levels of inflammatory protein NF-kappaB and COX-2 in DSS + NC group was decreased significantly (P<0.05).	dss	87-90	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	64-73
32239858-12	2019	(3) Compared with DSS group, the levels of inflammatory protein NF-kappaB and COX-2 in DSS + NC group was decreased significantly (P<0.05).	dss	87-90	cytochrome c oxidase II, mitochondrial	Mus musculus	78-83
31671695-9	2019	Patients with AF1q-positive EC relapsed and died earlier compared to patients with AF1q-negative EC (disease-free survival (DFS), p = 0.0005; disease-specific survival (DSS), p = 0.003); in the multivariable Cox regression model, AF1q proved to be an independent prognostic marker (DFS, p = 0.01; DSS, p = 0.03).	dss	169-172	MLLT11 transcription factor 7 cofactor	Homo sapiens	14-18
31671695-10	2019	AF1q is associated with WNT and STAT signaling; it impairs and independently predicts DFS and DSS in patients with resectable EC.	dss	94-97	MLLT11 transcription factor 7 cofactor	Homo sapiens	0-4
32257220-15	2020	Conclusions: Up-regulated expression of MGP was found in UC patients and DSS-induced colitis.	dss	73-76	matrix Gla protein	Homo sapiens	40-43
31582793-4	2019	DSS was administered to Tmem173gt (STING-mutant) mice and to wild-type mice co-treated with DSS and a STING agonist.	dss	0-3	stimulator of interferon response cGAMP interactor 1	Mus musculus	24-31
31687082-3	2019	However, the effect of AL-1 on DSS-induced murine colitis and the underlying mechanisms are yet unknown.	dss	31-34	ephrin A5	Mus musculus	23-27
31687082-4	2019	In the present study, we aimed to investigate the therapeutic potential of AL-1 against DSS-induced UC in mice and to define its mechanisms of action.	dss	88-91	ephrin A5	Mus musculus	75-79
31687082-7	2019	Moreover, AL-1 reversed DSS-altered expression of inflammatory cytokines in DSS-induced colitis mice.	dss	24-27	ephrin A5	Mus musculus	10-14
31687082-7	2019	Moreover, AL-1 reversed DSS-altered expression of inflammatory cytokines in DSS-induced colitis mice.	dss	76-79	ephrin A5	Mus musculus	10-14
31687082-11	2019	In conclusion, AL-1 alleviated DSS-induced murine colitis by inhibiting activation of the NF-kappaB and MAPK signaling pathways.	dss	31-34	ephrin A5	Mus musculus	15-19
31687082-11	2019	In conclusion, AL-1 alleviated DSS-induced murine colitis by inhibiting activation of the NF-kappaB and MAPK signaling pathways.	dss	31-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
31488881-8	2019	T stage, vascular/lymphatic invasion and CD4 + T-cell density were independent prognostic indicators for DSS.	dss	105-108	CD4 molecule	Homo sapiens	41-44
31264118-8	2019	In pT3-4 disease, a tumor &gt; 4 cm/DOI &gt; 10 mm was an independent adverse prognosticator for 5-year DSS rate, DOI &gt; 20 mm was an independent adverse prognosticator for 5-year DSS and OS rates, whereas through cortex/skin invasion independently predicted 5-year OS rates.	dss	104-107	zinc finger protein 135	Homo sapiens	3-6
31264118-8	2019	In pT3-4 disease, a tumor &gt; 4 cm/DOI &gt; 10 mm was an independent adverse prognosticator for 5-year DSS rate, DOI &gt; 20 mm was an independent adverse prognosticator for 5-year DSS and OS rates, whereas through cortex/skin invasion independently predicted 5-year OS rates.	dss	182-185	zinc finger protein 135	Homo sapiens	3-6
31271845-6	2019	In disagreement with our hypothesis, P2Y6 deficient mice were more susceptible to inflammation induced by DSS than WT mice.	dss	106-109	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	37-41
31271845-7	2019	DSS treated-P2ry6-/- mice showed increased histological damage and increased neutrophil and macrophage infiltration that correlated with increased mRNA levels of the chemokines KC and MCP-1.	dss	0-3	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	12-17
31271845-7	2019	DSS treated-P2ry6-/- mice showed increased histological damage and increased neutrophil and macrophage infiltration that correlated with increased mRNA levels of the chemokines KC and MCP-1.	dss	0-3	mast cell protease 1	Mus musculus	184-189
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	12-17
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interferon gamma	Mus musculus	136-145
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interleukin 17A	Mus musculus	150-156
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interferon gamma	Mus musculus	205-214
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interleukin 17A	Mus musculus	216-222
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interleukin 6	Mus musculus	224-228
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interleukin 23, alpha subunit p19	Mus musculus	230-235
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	interleukin 1 beta	Mus musculus	240-248
31271845-8	2019	DSS treated-P2ry6-/- mice exhibited also higher levels of Th17/Th1 lymphocytes in their colon which correlated with increased levels of IFN-gamma and IL-17A in the sera as well as increased mRNA levels of IFN-gamma, IL-17A, IL-6, IL-23 and IL-1beta in P2ry6-/- colons.	dss	0-3	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	252-257
31271845-10	2019	Importantly, injection of anti-IL-17 intraperitoneally partially protected P2ry6-/- mice from DSS-induced colitis.	dss	94-97	interleukin 17A	Mus musculus	31-36
31271845-10	2019	Importantly, injection of anti-IL-17 intraperitoneally partially protected P2ry6-/- mice from DSS-induced colitis.	dss	94-97	pyrimidinergic receptor P2Y, G-protein coupled, 6	Mus musculus	75-80
31500429-11	2019	Compared to wt-KRAS, m-KRAS was associated with a reduced DSS.	dss	58-61	KRAS proto-oncogene, GTPase	Homo sapiens	15-19
31500429-11	2019	Compared to wt-KRAS, m-KRAS was associated with a reduced DSS.	dss	58-61	KRAS proto-oncogene, GTPase	Homo sapiens	23-27
31429085-0	2019	Upregulation of PD-1 follows tumour development in the AOM/DSS model of inflammation-induced colorectal cancer in mice.	dss	59-62	programmed cell death 1	Mus musculus	16-20
31104313-9	2019	Finally, mice treated with MD-1 AS-ODN exhibited increased messenger RNA levels of TLR4 and MyD88 after DSS exposure and showed enhanced nuclear factor (NF)-kappaB activation compared with the control.	dss	104-107	toll-like receptor 4	Mus musculus	83-87
31104313-9	2019	Finally, mice treated with MD-1 AS-ODN exhibited increased messenger RNA levels of TLR4 and MyD88 after DSS exposure and showed enhanced nuclear factor (NF)-kappaB activation compared with the control.	dss	104-107	myeloid differentiation primary response gene 88	Mus musculus	92-97
31104313-10	2019	Taken together, specifically suppression of MD-1 in colon tissues with AS-ODN exacerbates DSS-induced experimental colitis in mice, which is possibly related to activation of TLR4/NF-kappaB signaling.	dss	90-93	toll-like receptor 4	Mus musculus	175-179
31301405-9	2019	Moreover DSS treatment increased PGE2 and 8-iso-PGF2alpha levels, along with COX-2 and TNF-alpha gene expression more markedly in colon specimens of -/- mice compared to controls.	dss	9-12	cytochrome c oxidase II, mitochondrial	Mus musculus	77-82
31194881-6	2019	In line with previous reports, DSS-induced acute and chronic colitis was exacerbated in IL-10-/- mice compared to wild-type (WT) controls.	dss	31-34	interleukin 10	Mus musculus	88-93
30270604-4	2019	Secondly, the probiotic candidates were rescreened by examining the induction ability of IL-10 (anti-inflammatory factor) production in dextran sodium sulfate (DSS)- induced colitis mice, and Lactobacillus sakei 07 (L07) was identified and selected as the probiotic P. In the end, fourteen bifidobacterium strains isolated from healthy man stools were examined for their antimicrobial activity.	dss	160-163	interleukin 10	Mus musculus	89-94
30270604-6	2019	Moreover, the colonic IL-6 and TNF-alpha expression of the DSS- induced colitis mice treated with L. sakei 07 (L07) - B. bifidum B10 combination (PB) significantly decreased and the IL-10 expression were up-regulated by PB compared to the DSS group.	dss	59-62	interleukin 6	Mus musculus	22-26
30270604-6	2019	Moreover, the colonic IL-6 and TNF-alpha expression of the DSS- induced colitis mice treated with L. sakei 07 (L07) - B. bifidum B10 combination (PB) significantly decreased and the IL-10 expression were up-regulated by PB compared to the DSS group.	dss	59-62	tumor necrosis factor	Mus musculus	31-40
30270604-6	2019	Moreover, the colonic IL-6 and TNF-alpha expression of the DSS- induced colitis mice treated with L. sakei 07 (L07) - B. bifidum B10 combination (PB) significantly decreased and the IL-10 expression were up-regulated by PB compared to the DSS group.	dss	59-62	interleukin 10	Mus musculus	182-187
31132297-4	2019	In an initial series of studies focused on trinitrobenzene sulfonic acid (TNBS)-colitis and dextran sodium sulfate (DSS)-colitis we showed that down-regulation of intestinal RICK expression in NOD2-intact mice by intra-rectal administration of a plasmid expressing RICK-specific siRNA was accompanied by down-regulation of pro-inflammatory cytokine responses in the colon and protection of the mice from experimental colitis.	dss	116-119	receptor (TNFRSF)-interacting serine-threonine kinase 2	Mus musculus	174-178
31555304-4	2019	We found that PHLPP-/- mice were protected from dextran sodium sulfate (DSS)-induced septic colitis characterized by minimal body weight-loss, alleviated colon tissue destruction and reduced clinical symptoms.	dss	72-75	PH domain and leucine rich repeat protein phosphatase 1	Mus musculus	14-19
31555304-6	2019	Further, adoptive transfer of PHLPP deficient neutrophils to WT mice is sufficient to potently alleviate the severity of DSS-induced colitis.	dss	121-124	PH domain and leucine rich repeat protein phosphatase 1	Mus musculus	30-35
31177914-7	2019	We also found that IRGM suppresses NLRP3-mediated exacerbated outcomes of dextran sodium sulfate (DSS)-induced colitis in a mouse model.	dss	98-101	predicted gene, 46612	Mus musculus	19-23
31177914-7	2019	We also found that IRGM suppresses NLRP3-mediated exacerbated outcomes of dextran sodium sulfate (DSS)-induced colitis in a mouse model.	dss	98-101	NLR family, pyrin domain containing 3	Mus musculus	35-40
31297554-10	2019	In addition, both the AR:ERalpha ratio and PDEF:ERalpha ratio were independent predictors of DFS (both P &lt; 0.0001) and DSS (P = 0.001 and P &lt; 0.0001, respectively).	dss	122-125	estrogen receptor 1	Homo sapiens	25-32
31297554-10	2019	In addition, both the AR:ERalpha ratio and PDEF:ERalpha ratio were independent predictors of DFS (both P &lt; 0.0001) and DSS (P = 0.001 and P &lt; 0.0001, respectively).	dss	122-125	SAM pointed domain containing ETS transcription factor	Homo sapiens	43-47
31297554-10	2019	In addition, both the AR:ERalpha ratio and PDEF:ERalpha ratio were independent predictors of DFS (both P &lt; 0.0001) and DSS (P = 0.001 and P &lt; 0.0001, respectively).	dss	122-125	estrogen receptor 1	Homo sapiens	48-55
31454000-1	2019	In this study, we aimed at investigating the antiinflammatory activity of the freeze-dried fruit powder of Actinidia arguta (FAA) on dextran sulphate sodium (DSS)-induced ulcerative colitis (UC) in mice and the effect of its extract on lipopolysaccharide (LPS)-stimulated RAW 264.7 macrophages.	dss	158-161	fumarylacetoacetate hydrolase	Mus musculus	125-128
31429085-9	2019	We also observed an upregulation of PD-L1 and PD-L2 mRNA expression throughout the AOM/DSS regime.	dss	87-90	CD274 antigen	Mus musculus	36-41
31429085-9	2019	We also observed an upregulation of PD-L1 and PD-L2 mRNA expression throughout the AOM/DSS regime.	dss	87-90	programmed cell death 1 ligand 2	Mus musculus	46-51
31429085-10	2019	Blocking PD-1 signalling with an anti-PD1 antibody did not affect the tumour burden in the AOM/DSS-treated mice, but did potentiate the weight loss in the third DSS cycle, indicating possible immune-mediated toxicity.	dss	161-164	programmed cell death 1	Mus musculus	9-13
31079293-7	2019	Levels of total and phosphorylated alpha-synuclein were elevated in enteric and brain neurons in DSS-treated PD mice, suggesting that mild gut inflammation accelerates alpha-synuclein pathology.	dss	97-100	synuclein, alpha	Mus musculus	35-50
31215020-2	2019	Using wild-type strains that differ in their IgA response but harbor a diverse gut microbiome, we found that the IgA-high strain CBA/CaJ (CBA) is resistant to acute colitis induced with dextran sodium sulfate (DSS), unlike the IgA-low strain C57BL/6 (B6).	dss	210-213	immunoglobulin heavy constant alpha	Mus musculus	113-116
31215020-2	2019	Using wild-type strains that differ in their IgA response but harbor a diverse gut microbiome, we found that the IgA-high strain CBA/CaJ (CBA) is resistant to acute colitis induced with dextran sodium sulfate (DSS), unlike the IgA-low strain C57BL/6 (B6).	dss	210-213	immunoglobulin heavy constant alpha	Mus musculus	113-116
31248980-6	2019	We found that the specific deletion of COX-1 in platelets, which recapitulated the human pharmacodynamics of low-dose aspirin, that is, suppression of platelet thromboxane (TX)A2 production associated with substantial sparing of the systemic production of prostacyclin, resulted in milder symptoms of colitis, in the acute phase, and almost complete recovery from the disease after DSS withdrawal.	dss	382-385	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	39-44
31308480-6	2019	Il13ra2-/- mice were modestly protected from induction of dextran sodium sulfate (DSS)-induced colitis.	dss	82-85	interleukin 13 receptor, alpha 2	Mus musculus	0-7
31233664-4	2019	Here, we found that C/EBPdelta knockout mice showed enhanced susceptibility to dextran sodium sulfate (DSS)-induced colitis, a mouse model of IBD, which was associated with severe colonic inflammation and mucosal damage with increased IEC apoptosis.	dss	103-106	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	20-30
31233664-5	2019	Additionally, DSS stimulation induced increased expression of pro-apoptotic BH3-only protein Bim in the colon of C/EBPdelta knockout mice.	dss	14-17	BCL2-like 11 (apoptosis facilitator)	Mus musculus	93-96
31233664-5	2019	Additionally, DSS stimulation induced increased expression of pro-apoptotic BH3-only protein Bim in the colon of C/EBPdelta knockout mice.	dss	14-17	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	113-123
31233664-6	2019	Collectively, our findings demonstrate that C/EBPdelta plays an essential role in suppressing DSS-induced colitis, likely by attenuating IEC apoptosis.	dss	94-97	CCAAT/enhancer binding protein (C/EBP), delta	Mus musculus	44-54
31328454-12	2019	Low-grade EC patients with elevated CA-125 revealed a DFS of 80.6% and DSS of 87.1%, compared to 92.1% and 97.2% in low-grade EC patients with normal CA-125.	dss	71-74	mucin 16, cell surface associated	Homo sapiens	36-42
31328454-13	2019	CONCLUSION: Preoperative elevated CA-125 was associated with poor prognostic features and independently associated with DFS and DSS.	dss	128-131	mucin 16, cell surface associated	Homo sapiens	34-40
31470289-4	2019	DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) alpha, interleukin (IL) 6, and IL-17a.	dss	89-92	F11 receptor	Mus musculus	256-286
31470289-4	2019	DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) alpha, interleukin (IL) 6, and IL-17a.	dss	89-92	occludin	Mus musculus	288-296
31470289-4	2019	DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) alpha, interleukin (IL) 6, and IL-17a.	dss	89-92	tumor necrosis factor	Mus musculus	372-405
31470289-4	2019	DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) alpha, interleukin (IL) 6, and IL-17a.	dss	89-92	interleukin 6	Mus musculus	407-425
31470289-4	2019	DSS administration induced acute colitis in mice, whereas the propolis extract mitigated DSS-induced weight loss; colon shortening; increased plasma levels of lipopolysaccharide-binding protein; reduced expression of TJ proteins, such as zonula occludens, junctional adhesion molecule-A, occludin, and claudins; and increased expression of inflammatory cytokines, such as tumor necrosis factor (TNF) alpha, interleukin (IL) 6, and IL-17a.	dss	89-92	interleukin 17A	Mus musculus	431-437
31386886-7	2019	Indeed, concomitant treatment with CNT ameliorated DSS-induced colitis symptoms, tissue damage, inflammatory cell infiltration, and proinflammatory cytokine production in the colon, and also reversed the activation of NF-kappaB and suppression of PPARgamma.	dss	51-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	218-227
31386886-7	2019	Indeed, concomitant treatment with CNT ameliorated DSS-induced colitis symptoms, tissue damage, inflammatory cell infiltration, and proinflammatory cytokine production in the colon, and also reversed the activation of NF-kappaB and suppression of PPARgamma.	dss	51-54	peroxisome proliferator activated receptor gamma	Mus musculus	247-256
31079293-7	2019	Levels of total and phosphorylated alpha-synuclein were elevated in enteric and brain neurons in DSS-treated PD mice, suggesting that mild gut inflammation accelerates alpha-synuclein pathology.	dss	97-100	synuclein, alpha	Mus musculus	168-183
31079293-8	2019	Markers of inflammation in the colon and brain, but not in the blood, were elevated in DSS-treated PD mice, consistent with retrograde transneuronal propagation of alpha-synuclein pathology and neuroinflammation from the gut to the brain.	dss	87-90	synuclein, alpha	Mus musculus	164-179
32259068-6	2019	Biodistribution studies of radiolabeled F8-VEGFC revealed a specific accumulation of the antibody in the colon of DSS-administered mice, as compared to an untargeted VEGFC fusion protein (KSF-VEGFC) (binding the irrelevant hen egg lysozyme antigen).	dss	114-117	vascular endothelial growth factor C	Mus musculus	43-48
31094420-10	2019	Faecal microbiota transplantation [FMT] with NOD2-/-CD1d-/- mice faeces into wild-type mice aggravated DSS-induced colitis, while FMT with wild-type mice faeces into NOD2-/-CD1d-/- mice alleviated DSS-induced colitis.	dss	103-106	nucleotide-binding oligomerization domain containing 2	Mus musculus	45-49
31094420-10	2019	Faecal microbiota transplantation [FMT] with NOD2-/-CD1d-/- mice faeces into wild-type mice aggravated DSS-induced colitis, while FMT with wild-type mice faeces into NOD2-/-CD1d-/- mice alleviated DSS-induced colitis.	dss	103-106	CD1d1 antigen	Mus musculus	52-56
31262973-0	2019	Protective effects of oxymatrine against DSS-induced acute intestinal inflammation in mice via blocking the RhoA/ROCK signaling pathway.	dss	41-44	ras homolog family member A	Mus musculus	108-112
31382637-5	2019	MMI-0100 suppressed DSS-induced activation of CD11b+ and F4/80 positive cell, and dramatically decreased the expression of a series of pro-inflammatory cytokines such as TNF-alpha, IL-6, IL-1beta, TGF- beta, IFN-gamma, IL-17A, COX-2 and iNOS.	dss	20-23	integrin subunit alpha M	Homo sapiens	46-51
31382637-8	2019	The anti-inflammatory effects of MMI-0100 on DSS-induced colitis were achieved by down-regulating the phosphorylation level of MK2, IkappaBalpha and p65 protein.	dss	45-48	MAP kinase-activated protein kinase 2	Mus musculus	127-130
31382637-8	2019	The anti-inflammatory effects of MMI-0100 on DSS-induced colitis were achieved by down-regulating the phosphorylation level of MK2, IkappaBalpha and p65 protein.	dss	45-48	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	132-144
31382637-8	2019	The anti-inflammatory effects of MMI-0100 on DSS-induced colitis were achieved by down-regulating the phosphorylation level of MK2, IkappaBalpha and p65 protein.	dss	45-48	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	149-152
31373851-10	2019	Both univariate analyses and further multivariate analyses revealed the close association between ficolin-3 levels and EAC (For OS and DSS, all p < 0.05).	dss	135-138	ficolin 3	Homo sapiens	98-107
31373851-12	2019	When dividing the ficolin-3 levels into quartiles, patients with higher serum ficolin-3 levels showed a trend toward longer OS and DSS no matter whether they were diagnosed as ESCC or EAC (HR 0.21-0.55, all p < 0.05).	dss	131-134	ficolin 3	Homo sapiens	78-87
31373851-13	2019	Conclusions: Serum ficolin-3 levels were identified as an independent prognostic biomarker for DSS and OS in Chinese patients with EC, especially EAC.	dss	95-98	ficolin 3	Homo sapiens	19-28
31296924-5	2019	Numbers of Tregs and IFN-gamma+, IL-13+ and IL-17A+ CD4+ T helper (Th) cells in mesenteric lymph nodes increased during chronic DSS administration and mRNA for IFN-gamma and IL-17 in the inflamed colon tissue was upregulated.	dss	128-131	interferon gamma	Mus musculus	21-30
31308463-0	2019	Therapeutic effect of gold nanoparticles on DSS-induced ulcerative colitis in mice with reference to interleukin-17 expression.	dss	44-47	interleukin 17A	Mus musculus	101-115
31296924-5	2019	Numbers of Tregs and IFN-gamma+, IL-13+ and IL-17A+ CD4+ T helper (Th) cells in mesenteric lymph nodes increased during chronic DSS administration and mRNA for IFN-gamma and IL-17 in the inflamed colon tissue was upregulated.	dss	128-131	interleukin 13	Mus musculus	33-38
31296924-5	2019	Numbers of Tregs and IFN-gamma+, IL-13+ and IL-17A+ CD4+ T helper (Th) cells in mesenteric lymph nodes increased during chronic DSS administration and mRNA for IFN-gamma and IL-17 in the inflamed colon tissue was upregulated.	dss	128-131	interleukin 17A	Mus musculus	44-50
31296924-5	2019	Numbers of Tregs and IFN-gamma+, IL-13+ and IL-17A+ CD4+ T helper (Th) cells in mesenteric lymph nodes increased during chronic DSS administration and mRNA for IFN-gamma and IL-17 in the inflamed colon tissue was upregulated.	dss	128-131	CD4 antigen	Mus musculus	52-55
31296924-5	2019	Numbers of Tregs and IFN-gamma+, IL-13+ and IL-17A+ CD4+ T helper (Th) cells in mesenteric lymph nodes increased during chronic DSS administration and mRNA for IFN-gamma and IL-17 in the inflamed colon tissue was upregulated.	dss	128-131	interferon gamma	Mus musculus	160-169
31296924-5	2019	Numbers of Tregs and IFN-gamma+, IL-13+ and IL-17A+ CD4+ T helper (Th) cells in mesenteric lymph nodes increased during chronic DSS administration and mRNA for IFN-gamma and IL-17 in the inflamed colon tissue was upregulated.	dss	128-131	interleukin 17A	Mus musculus	44-49
30972812-9	2019	High expression level of COL5A1 was also correlated with poor disease-specific survival (DSS, P = 0.001) and disease-free survival (DFS, P = 0.003) in TSCC patients.	dss	89-92	collagen type V alpha 1 chain	Homo sapiens	25-31
31076664-5	2019	We demonstrated herein that TRAIL significantly suppressed gut inflammation and reduced the severity of colitis in a dextran sodium sulfate (DSS)-induced colitis model.	dss	141-144	TNF superfamily member 10	Homo sapiens	28-33
30790702-6	2019	Socially defeated mice with KA treatment displayed enhanced vulnerability to subsequent dextran sulphate sodium (DSS)-induced colonic injury and inflammatory disturbance, and this effect was reversed by autophagic inhibition that blocked the NLRP3-suppressive effect of KA.	dss	113-116	NLR family, pyrin domain containing 3	Mus musculus	242-247
30972812-11	2019	Moreover, co-expression level of high (COL5A1)2 /low (COL5A2) heterotrimer was correlated with worse DSS (P = 0.004) and DFS (P = 0.004).	dss	101-104	collagen type V alpha 1 chain	Homo sapiens	39-47
30972812-11	2019	Moreover, co-expression level of high (COL5A1)2 /low (COL5A2) heterotrimer was correlated with worse DSS (P = 0.004) and DFS (P = 0.004).	dss	101-104	collagen type V alpha 2 chain	Homo sapiens	54-60
31260491-9	2019	The random effects model showed that elevated CRP level was significantly correlated with poor DSS (HR = 2.08; 95% CI: 1.33-3.24; p &lt; 0.001).	dss	95-98	C-reactive protein	Homo sapiens	46-49
31260491-10	2019	After excluding the heterogeneous study, the fixed effects model showed that elevated CRP level was firmly correlated with poor DSS (HR = 2.36; 95% CI: 1.84-3.03; p &lt; 0.001).	dss	128-131	C-reactive protein	Homo sapiens	86-89
31260491-12	2019	CONCLUSION: The results of this meta-analysis suggest that elevated pretreatment serum CRP level could serve as an independent risk factor for poor DSS and DFS/RFS in STS patents.	dss	148-151	C-reactive protein	Homo sapiens	87-90
31249571-5	2019	Mechanistically, our data showed that F. nucleatum aggravated dextran sodium sulfate (DSS)-induced colitis in the production of Th1-related cytokines IFN-gamma through the AKT2 signaling pathway in vitro and in vivo.	dss	86-89	interferon gamma	Homo sapiens	150-159
31242213-3	2019	Dextran sodium sulfate (DSS)-administration promoted colonic tumor development in CDX2P-Cre; Apc+/flox mice, and these tumors were associated with loss of Apc heterozygosity, as confirmed by observation of well-differentiated adenocarcinomas with beta-catenin accumulation in tumor cell cytoplasm.	dss	24-27	caudal type homeobox 2	Mus musculus	82-86
31242213-3	2019	Dextran sodium sulfate (DSS)-administration promoted colonic tumor development in CDX2P-Cre; Apc+/flox mice, and these tumors were associated with loss of Apc heterozygosity, as confirmed by observation of well-differentiated adenocarcinomas with beta-catenin accumulation in tumor cell cytoplasm.	dss	24-27	APC, WNT signaling pathway regulator	Mus musculus	93-96
31242213-3	2019	Dextran sodium sulfate (DSS)-administration promoted colonic tumor development in CDX2P-Cre; Apc+/flox mice, and these tumors were associated with loss of Apc heterozygosity, as confirmed by observation of well-differentiated adenocarcinomas with beta-catenin accumulation in tumor cell cytoplasm.	dss	24-27	APC, WNT signaling pathway regulator	Mus musculus	155-158
31242213-3	2019	Dextran sodium sulfate (DSS)-administration promoted colonic tumor development in CDX2P-Cre; Apc+/flox mice, and these tumors were associated with loss of Apc heterozygosity, as confirmed by observation of well-differentiated adenocarcinomas with beta-catenin accumulation in tumor cell cytoplasm.	dss	24-27	catenin (cadherin associated protein), beta 1	Mus musculus	247-259
31242213-7	2019	Synbiotics-treatment suppressed DSS-induced expression of IL-6, STAT-3, COX-2, and TNF-alpha gene transcripts in normal colonic epithelium, indicating the possibility of suppressing tumor development.	dss	32-35	interleukin 6	Mus musculus	58-62
31242213-7	2019	Synbiotics-treatment suppressed DSS-induced expression of IL-6, STAT-3, COX-2, and TNF-alpha gene transcripts in normal colonic epithelium, indicating the possibility of suppressing tumor development.	dss	32-35	signal transducer and activator of transcription 3	Mus musculus	64-70
31242213-7	2019	Synbiotics-treatment suppressed DSS-induced expression of IL-6, STAT-3, COX-2, and TNF-alpha gene transcripts in normal colonic epithelium, indicating the possibility of suppressing tumor development.	dss	32-35	cytochrome c oxidase II, mitochondrial	Mus musculus	72-77
31242213-7	2019	Synbiotics-treatment suppressed DSS-induced expression of IL-6, STAT-3, COX-2, and TNF-alpha gene transcripts in normal colonic epithelium, indicating the possibility of suppressing tumor development.	dss	32-35	tumor necrosis factor	Mus musculus	83-92
31189465-0	2019	TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells.	dss	86-89	triggering receptor expressed on myeloid cells 1	Mus musculus	0-6
31189465-0	2019	TREM-1-dependent M1 macrophage polarization restores intestinal epithelium damaged by DSS-induced colitis by activating IL-22-producing innate lymphoid cells.	dss	86-89	interleukin 22	Mus musculus	120-125
31189465-9	2019	Accordingly, DSS-mediated damage was ameliorated by supplying exogenous IL-22 and TREM-1-expressing macrophages to TREM-1-deficient mice.	dss	13-16	interleukin 22	Mus musculus	72-77
31189465-9	2019	Accordingly, DSS-mediated damage was ameliorated by supplying exogenous IL-22 and TREM-1-expressing macrophages to TREM-1-deficient mice.	dss	13-16	triggering receptor expressed on myeloid cells 1	Mus musculus	82-88
31189465-10	2019	CONCLUSIONS: TREM-1 plays a crucial role in regulating IL-22 production by ILC3 through modulating M1-macrophage polarization during DSS-induced acute colitis.	dss	133-136	triggering receptor expressed on myeloid cells 1	Mus musculus	13-19
31189465-10	2019	CONCLUSIONS: TREM-1 plays a crucial role in regulating IL-22 production by ILC3 through modulating M1-macrophage polarization during DSS-induced acute colitis.	dss	133-136	interleukin 22	Mus musculus	55-60
31061170-5	2019	We demonstrate that Imp1 Delta IEC mice exhibit enhanced recovery following dextran sodium sulfate (DSS)-mediated colonic injury.	dss	100-103	imprintor 1	Mus musculus	20-24
31097594-2	2019	In an ongoing forward genetic screen for N-ethyl-N-nitrosourea (ENU)-induced mutations that increase susceptibility to dextran sodium sulfate (DSS)-induced colitis in mice, we identified two nonsense mutations in Lrba Although Treg cells have been a main focus in LRBA research to date, we found that dendritic cells (DCs) contribute significantly to DSS-induced intestinal inflammation in LRBA-deficient mice.	dss	143-146	LPS-responsive beige-like anchor	Mus musculus	213-217
31097594-2	2019	In an ongoing forward genetic screen for N-ethyl-N-nitrosourea (ENU)-induced mutations that increase susceptibility to dextran sodium sulfate (DSS)-induced colitis in mice, we identified two nonsense mutations in Lrba Although Treg cells have been a main focus in LRBA research to date, we found that dendritic cells (DCs) contribute significantly to DSS-induced intestinal inflammation in LRBA-deficient mice.	dss	143-146	LPS-responsive beige-like anchor	Mus musculus	264-268
31097594-2	2019	In an ongoing forward genetic screen for N-ethyl-N-nitrosourea (ENU)-induced mutations that increase susceptibility to dextran sodium sulfate (DSS)-induced colitis in mice, we identified two nonsense mutations in Lrba Although Treg cells have been a main focus in LRBA research to date, we found that dendritic cells (DCs) contribute significantly to DSS-induced intestinal inflammation in LRBA-deficient mice.	dss	143-146	LPS-responsive beige-like anchor	Mus musculus	390-394
31097594-2	2019	In an ongoing forward genetic screen for N-ethyl-N-nitrosourea (ENU)-induced mutations that increase susceptibility to dextran sodium sulfate (DSS)-induced colitis in mice, we identified two nonsense mutations in Lrba Although Treg cells have been a main focus in LRBA research to date, we found that dendritic cells (DCs) contribute significantly to DSS-induced intestinal inflammation in LRBA-deficient mice.	dss	351-354	LPS-responsive beige-like anchor	Mus musculus	213-217
31097594-4	2019	Substantial reductions in cytokine expression and sensitivity to DSS in LRBA-deficient mice were caused by knockout of Unc93b1, a chaperone necessary for trafficking of TLR3, TLR7, and TLR9 to endosomes.	dss	65-68	LPS-responsive beige-like anchor	Mus musculus	72-76
31097594-4	2019	Substantial reductions in cytokine expression and sensitivity to DSS in LRBA-deficient mice were caused by knockout of Unc93b1, a chaperone necessary for trafficking of TLR3, TLR7, and TLR9 to endosomes.	dss	65-68	unc-93 homolog B1, TLR signaling regulator	Mus musculus	119-126
31097594-4	2019	Substantial reductions in cytokine expression and sensitivity to DSS in LRBA-deficient mice were caused by knockout of Unc93b1, a chaperone necessary for trafficking of TLR3, TLR7, and TLR9 to endosomes.	dss	65-68	toll-like receptor 3	Mus musculus	169-173
31097594-4	2019	Substantial reductions in cytokine expression and sensitivity to DSS in LRBA-deficient mice were caused by knockout of Unc93b1, a chaperone necessary for trafficking of TLR3, TLR7, and TLR9 to endosomes.	dss	65-68	toll-like receptor 9	Mus musculus	185-189
30587856-7	2019	The urinary ((total AGT-intact AGT)/intact AGT) ratio, an indicator of intrarenal renin activity, was significantly suppressed in HS-treated DSS rats.	dss	141-144	angiotensinogen	Rattus norvegicus	31-34
30706580-8	2019	Chemotherapy improved overall survival (OS) and disease-specific survival (DSS) in patients with CFOS who had tumors in the maxilla, positive resection margins, or high-grade tumors.	dss	75-78	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	97-101
31028726-9	2019	Moreover, the expression of DCLK1 was found to be an independent marker of poor prognosis for disease- specific survival (DSS) (P = .048) in bladder carcinomas.	dss	122-125	doublecortin like kinase 1	Homo sapiens	28-33
31028726-10	2019	Our observations showed that DCLK1 expression was associated with more aggressive tumor behavior, more advanced disease, and poorer DSS in patients with bladder carcinomas.	dss	132-135	doublecortin like kinase 1	Homo sapiens	29-34
30587856-5	2019	HS-treated DSS rats developed hypertension, albuminuria, and glomerular injury, which were associated with increased glomerular desmin staining and reduced mRNA levels of glomerular podocin and nephrin.	dss	11-14	NPHS2 stomatin family member, podocin	Rattus norvegicus	182-189
30771347-7	2019	Further comparisons and bioinformatics analysis demonstrated that among the identified DEPs, 26, including Hist2h2be, Tubb3, and five immunoglobulins, were oppositely regulated by DSS and DSS plus berberine treatments.	dss	180-183	H2B clustered histone 21	Mus musculus	107-116
30587856-5	2019	HS-treated DSS rats developed hypertension, albuminuria, and glomerular injury, which were associated with increased glomerular desmin staining and reduced mRNA levels of glomerular podocin and nephrin.	dss	11-14	NPHS1 adhesion molecule, nephrin	Rattus norvegicus	194-201
30587856-7	2019	The urinary ((total AGT-intact AGT)/intact AGT) ratio, an indicator of intrarenal renin activity, was significantly suppressed in HS-treated DSS rats.	dss	141-144	angiotensinogen	Rattus norvegicus	20-23
30587856-7	2019	The urinary ((total AGT-intact AGT)/intact AGT) ratio, an indicator of intrarenal renin activity, was significantly suppressed in HS-treated DSS rats.	dss	141-144	angiotensinogen	Rattus norvegicus	31-34
30807536-6	2019	CONCLUSIONS: DSS samples could be a useful alternative for DPD activity screening, particularly in locations with limited access to highly equipped laboratories.	dss	13-16	dihydropyrimidine dehydrogenase	Homo sapiens	59-62
30771347-7	2019	Further comparisons and bioinformatics analysis demonstrated that among the identified DEPs, 26, including Hist2h2be, Tubb3, and five immunoglobulins, were oppositely regulated by DSS and DSS plus berberine treatments.	dss	180-183	tubulin, beta 3 class III	Mus musculus	118-123
30771347-7	2019	Further comparisons and bioinformatics analysis demonstrated that among the identified DEPs, 26, including Hist2h2be, Tubb3, and five immunoglobulins, were oppositely regulated by DSS and DSS plus berberine treatments.	dss	188-191	H2B clustered histone 21	Mus musculus	107-116
30771347-7	2019	Further comparisons and bioinformatics analysis demonstrated that among the identified DEPs, 26, including Hist2h2be, Tubb3, and five immunoglobulins, were oppositely regulated by DSS and DSS plus berberine treatments.	dss	188-191	tubulin, beta 3 class III	Mus musculus	118-123
30623320-12	2019	Consistent with previous work, genetic ablation of TGR5 increased the severity of DSS-induced colitis.	dss	82-85	G protein-coupled bile acid receptor 1	Mus musculus	51-55
30615266-6	2019	MAIN OUTCOME MEASURES: Impact of TNM classification, grading, sex, age, gender, type of therapy, response to therapy and p16 status on disease-specific (DSS) and disease-free survival (DFS).	dss	153-156	teneurin transmembrane protein 1	Homo sapiens	33-36
31060167-8	2019	After the DSS administration, TRAIL(-/-) group developed more severe colitis than WT group, mainly manifesting higher disease activity index, reduction of colon length and increased infiltration of inflammatory cells.	dss	10-13	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	30-35
30982243-2	2019	This study is designed to investigate the role of ICC and the ANO1 channel in colonic transit disorder in dextran sodium sulfate (DSS)-treated colitis mice.	dss	130-133	anoctamin 1, calcium activated chloride channel	Mus musculus	62-66
30660494-9	2019	Kaplan-Meier survival analysis revealed that patients with high CHI3L1 expression had shorter DSS and MFS in both UTUC and UBUC (all P &lt; 0.05).	dss	94-97	chitinase 3 like 1	Homo sapiens	64-70
30660494-10	2019	In multivariate survival analyses, high expression of CHI3L1 acted as an independent prognostic factor for worse DSS (P &lt; 0.001 in UTUC and P = 0.036 in UBUC) and MFS (P = 0.002 in UTUC and P = 0.003 in UBUC) in both UTUC and UBUC groups.	dss	113-116	chitinase 3 like 1	Homo sapiens	54-60
31060167-10	2019	Conclusions: TRAIL deficiency not only promots the number and activity of Th17 cells in PBMC and in MLN, but also aggravats DSS-induced colitis in mice.	dss	124-127	tumor necrosis factor (ligand) superfamily, member 10	Mus musculus	13-18
30647081-8	2019	Univariable Cox regression reveals that a high-risk MIP score correlates with DSS (P = 0.015; HR = 3.2).	dss	78-81	cytochrome c oxidase subunit 8A	Homo sapiens	12-15
30670493-9	2019	HLA-A expression correlated with favorable DSS in PD-L1-negative tumors (P = 0.02).	dss	43-46	major histocompatibility complex, class I, A	Homo sapiens	0-5
30670493-6	2019	In contrast, high peritumoral CD4+ cell and TAM infiltration was associated with a worse DFS and DSS.	dss	97-100	CD4 molecule	Homo sapiens	30-33
30607536-14	2019	RESULTS: MOG-Ab titres were higher in Caucasians than in those with other ethnicities, and in patients with a more severe VA (VA &lt;= 20/100) or motor disability (DSS &gt;= 3.0) at onset (p = 0.006, 0.034, and 0.058, respectively).	dss	164-167	myelin oligodendrocyte glycoprotein	Homo sapiens	9-12
31097961-8	2019	Multivariable regression analysis showed that the revised TNM system, but not the 7th and 8th editions, was an independent factor for disease-specific survival (DSS) in the third step of the analysis.	dss	161-164	teneurin transmembrane protein 1	Homo sapiens	58-61
31097961-10	2019	Conclusion: The 8th edition of the AJCC TNM staging system is superior to the 7th edition for predicting the DSS rates of gastric cancer patients.	dss	109-112	teneurin transmembrane protein 1	Homo sapiens	40-43
31106136-13	2019	Stepwise Cox regression showed the two predictors for DSS were pTNM stage (P&lt;0.0001, odds ratio=19.633) and presence of metastatic lymph nodes (P=0.0004, odds ratio=0.1039).	dss	54-57	cytochrome c oxidase subunit 8A	Homo sapiens	9-12
30802726-4	2019	Moreover, protein expression of two tight junction proteins, claudin-3 and junctional adhesion molecule-A, was higher in DSS-administered mice that were fed naringenin than in the mice that did not receive naringenin.	dss	121-124	claudin 3	Mus musculus	61-105
30421387-22	2019	Association between DSS, sex and grade persisted both at univariate (p = 0.008 and p = 0.022, respectively) and multivariate Cox regression (CR) analysis (p = 0.014 and p = 0.038).	dss	20-23	cytochrome c oxidase subunit 8A	Homo sapiens	125-128
30538296-4	2019	Here, we show that Casp11-/- mice are highly susceptible to the azoxymethane (AOM)-DSS model of colitis-associated cancer (CAC), compared to their wild type (WT) littermates.	dss	83-86	caspase 4, apoptosis-related cysteine peptidase	Mus musculus	19-25
30452920-12	2019	Atf4DeltaIEC mice developed spontaneous enterocolitis and colitis of greater severity than control mice after administration of DSS.	dss	128-131	activating transcription factor 4	Mus musculus	0-4
30445446-6	2019	Strikingly, MTC-miR146b mimic oral administration protected miR-146b-deficient mice from dextran sodium sulphate [DSS] injury and the colitis-associated cancer process.	dss	114-117	microRNA 146b	Mus musculus	16-23
30445446-6	2019	Strikingly, MTC-miR146b mimic oral administration protected miR-146b-deficient mice from dextran sodium sulphate [DSS] injury and the colitis-associated cancer process.	dss	114-117	microRNA 146b	Mus musculus	60-68
30872783-5	2019	Kaplan-Meier curves revealed that low C6orf141 expression was significantly associated with shorter disease-specific survival (DSS) in patients with OSCC (log-rank P = 0.007).	dss	127-130	chromosome 6 open reading frame 141	Homo sapiens	38-46
30872783-6	2019	Multivariate analysis indicated that low C6orf141 expression was an independent prognostic biomarker for DSS (adjusted hazard ratio = 1.34; 95% confidence interval = 1.10-1.81; P = 0.05).	dss	105-108	chromosome 6 open reading frame 141	Homo sapiens	41-49
30930725-9	2019	DSS restored the neuronal OGD-mediated phosphorylation decrease in protein kinase alpha (PKA), extracellular signal-regulated protein kinases 1/2 (ERK1/2) and cAMP response element binding protein (CREB), in vitro.	dss	0-3	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	67-87
30930725-9	2019	DSS restored the neuronal OGD-mediated phosphorylation decrease in protein kinase alpha (PKA), extracellular signal-regulated protein kinases 1/2 (ERK1/2) and cAMP response element binding protein (CREB), in vitro.	dss	0-3	mitogen activated protein kinase 3	Rattus norvegicus	147-153
30930725-9	2019	DSS restored the neuronal OGD-mediated phosphorylation decrease in protein kinase alpha (PKA), extracellular signal-regulated protein kinases 1/2 (ERK1/2) and cAMP response element binding protein (CREB), in vitro.	dss	0-3	cAMP responsive element binding protein 1	Rattus norvegicus	159-196
30930725-9	2019	DSS restored the neuronal OGD-mediated phosphorylation decrease in protein kinase alpha (PKA), extracellular signal-regulated protein kinases 1/2 (ERK1/2) and cAMP response element binding protein (CREB), in vitro.	dss	0-3	cAMP responsive element binding protein 1	Rattus norvegicus	198-202
30930725-10	2019	PKA and ERK1/2 inhibition blocked the DSS-mediated effects on neuronal apoptosis and OGD-induced Arc downregulation.	dss	38-41	mitogen activated protein kinase 3	Rattus norvegicus	8-14
30930725-11	2019	In conclusion, DSS protects against CCH-mediated cognitive impairment and hippocampal damage via Arc upregulation, which is activated by the PKA/CREB and ERK/CREB signaling pathways.	dss	15-18	cAMP responsive element binding protein 1	Rattus norvegicus	145-149
30930725-11	2019	In conclusion, DSS protects against CCH-mediated cognitive impairment and hippocampal damage via Arc upregulation, which is activated by the PKA/CREB and ERK/CREB signaling pathways.	dss	15-18	Eph receptor B1	Rattus norvegicus	154-157
30930725-11	2019	In conclusion, DSS protects against CCH-mediated cognitive impairment and hippocampal damage via Arc upregulation, which is activated by the PKA/CREB and ERK/CREB signaling pathways.	dss	15-18	cAMP responsive element binding protein 1	Rattus norvegicus	158-162
30085020-7	2019	Both univariate and multivariate analyses for disease-specific survival (DSS) revealed that the PD-L1 status of carcinoma cells in metastatic lymph nodes and a higher FOXP3/CD8 ratio in the primary tumor were both significantly correlated with an eventual adverse clinical outcome of the patients (P = 0.0178, P = 0.0463, respectively).	dss	73-76	CD274 molecule	Homo sapiens	96-101
30085020-7	2019	Both univariate and multivariate analyses for disease-specific survival (DSS) revealed that the PD-L1 status of carcinoma cells in metastatic lymph nodes and a higher FOXP3/CD8 ratio in the primary tumor were both significantly correlated with an eventual adverse clinical outcome of the patients (P = 0.0178, P = 0.0463, respectively).	dss	73-76	forkhead box P3	Homo sapiens	167-172
30085020-7	2019	Both univariate and multivariate analyses for disease-specific survival (DSS) revealed that the PD-L1 status of carcinoma cells in metastatic lymph nodes and a higher FOXP3/CD8 ratio in the primary tumor were both significantly correlated with an eventual adverse clinical outcome of the patients (P = 0.0178, P = 0.0463, respectively).	dss	73-76	CD8a molecule	Homo sapiens	173-176
30930725-4	2019	The hippocampal expression of the activity-regulated cytoskeleton associated protein (Arc) following DSS administration was detected in vivo and in vitro and behavioral testing was used to investigate the role of Arc in the DSS-mediated rescue of CCH-induced neurotoxicity.	dss	101-104	activity-regulated cytoskeleton-associated protein	Rattus norvegicus	34-84
30701287-0	2019	ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation.	dss	82-85	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	17-22
30701287-0	2019	ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation.	dss	82-85	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	27-32
30701287-0	2019	ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation.	dss	82-85	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	34-38
30701287-0	2019	ABC transporters Mdr1a/1b, Bcrp1, Mrp2 and Mrp3 determine the sensitivity to PhIP/DSS-induced colon carcinogenesis and inflammation.	dss	82-85	prolactin family 2, subfamily c, member 4	Mus musculus	43-47
30452920-15	2019	Injections of DEFA1 reduced the severity of spontaneous enteritis and DSS-induced colitis in Atf4DeltaIEC mice.	dss	70-73	defensin, alpha 1	Mus musculus	14-19
30452920-15	2019	Injections of DEFA1 reduced the severity of spontaneous enteritis and DSS-induced colitis in Atf4DeltaIEC mice.	dss	70-73	activating transcription factor 4	Mus musculus	93-97
30846173-5	2019	PD-L2 expression was associated with reduced disease-specific survival (DSS) and disease-free survival (DFS) (P = 0.0266 and P = 0.0209, respectively).	dss	72-75	programmed cell death 1 ligand 2	Homo sapiens	0-5
30615542-8	2019	In this study, we elucidate the potential of LB-9, a novel probiotic LAB, to protect against colitis development using a dextran sodium sulfate (DSS)-induced mouse model of UC.	dss	145-148	coatomer protein complex, subunit gamma 2, opposite strand 2	Mus musculus	45-49
30615542-12	2019	Our study demonstrates that the LB-9 probiotic exhibits therapeutic potential for UC through suppression of TNF-alpha-mediated IEC apoptosis in a murine DSS-induced colitis model, with important biological implications for treatment of IBD in humans.	dss	153-156	coatomer protein complex, subunit gamma 2, opposite strand 2	Mus musculus	32-36
30615542-12	2019	Our study demonstrates that the LB-9 probiotic exhibits therapeutic potential for UC through suppression of TNF-alpha-mediated IEC apoptosis in a murine DSS-induced colitis model, with important biological implications for treatment of IBD in humans.	dss	153-156	tumor necrosis factor	Mus musculus	108-117
30823588-5	2019	The five-year overall survival (OS) and disease-specific survival (DSS) in pN1-3 OSCC patients were 62% and 71%, respectively.	dss	67-70	serpin family E member 2	Homo sapiens	75-78
30683736-3	2019	Among subjects with PIK3CA mutations or amplification, regular NSAID use (&gt;=6 mo) conferred markedly prolonged disease-specific survival (DSS; hazard ratio 0.23, P = 0.0032, 95% CI 0.09-0.62) and overall survival (OS; hazard ratio 0.31, P = 0.0043, 95% CI 0.14-0.69) compared with nonregular NSAID users.	dss	141-144	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	20-26
30683736-4	2019	For PIK3CA-altered HNSCC, predicted 5-yr DSS was 72% for NSAID users and 25% for nonusers; predicted 5-yr OS was 78% for regular NSAID users and 45% for nonregular users.	dss	41-44	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	4-10
30554117-4	2019	The results indicated that treatment with EVO ameliorated DSS-induced UC mice body weight loss, disease activity index (DAI), colon length shortening, colonic pathological damage, and myeloperoxidase (MPO) activity.	dss	58-61	myeloperoxidase	Mus musculus	184-199
30146676-4	2019	METHODS: We evaluated clinical signs and histopathology of acute colitis induced by dextran sodium sulfate (DSS) in OPN knockout and wild-type (WT) mice in vivo.	dss	108-111	secreted phosphoprotein 1	Mus musculus	116-119
30882084-6	2019	In the inflammatory study, IL-6 (interleukin 6) was decreased and IL-4 and IL-10 increased significantly in DSS group with yogurt fermented at general temperature (DYG) and that with yogurt fermented at low temperature (DYL) compared to that in DSS-induced colitic mice (DC), especially DYL had higher concentration of cytokines IL-4, and IL-10 than DYG.	dss	108-111	interleukin 6	Mus musculus	27-31
30882084-6	2019	In the inflammatory study, IL-6 (interleukin 6) was decreased and IL-4 and IL-10 increased significantly in DSS group with yogurt fermented at general temperature (DYG) and that with yogurt fermented at low temperature (DYL) compared to that in DSS-induced colitic mice (DC), especially DYL had higher concentration of cytokines IL-4, and IL-10 than DYG.	dss	108-111	interleukin 4	Mus musculus	66-70
30882084-6	2019	In the inflammatory study, IL-6 (interleukin 6) was decreased and IL-4 and IL-10 increased significantly in DSS group with yogurt fermented at general temperature (DYG) and that with yogurt fermented at low temperature (DYL) compared to that in DSS-induced colitic mice (DC), especially DYL had higher concentration of cytokines IL-4, and IL-10 than DYG.	dss	108-111	interleukin 10	Mus musculus	75-80
30882084-6	2019	In the inflammatory study, IL-6 (interleukin 6) was decreased and IL-4 and IL-10 increased significantly in DSS group with yogurt fermented at general temperature (DYG) and that with yogurt fermented at low temperature (DYL) compared to that in DSS-induced colitic mice (DC), especially DYL had higher concentration of cytokines IL-4, and IL-10 than DYG.	dss	108-111	interleukin 4	Mus musculus	329-333
30882084-6	2019	In the inflammatory study, IL-6 (interleukin 6) was decreased and IL-4 and IL-10 increased significantly in DSS group with yogurt fermented at general temperature (DYG) and that with yogurt fermented at low temperature (DYL) compared to that in DSS-induced colitic mice (DC), especially DYL had higher concentration of cytokines IL-4, and IL-10 than DYG.	dss	108-111	interleukin 10	Mus musculus	339-344
30132862-8	2019	These results indicate that mTOR inhibitor INK128 attenuates DSS-induced colitis via Treg expansion promoted by MDSCs.	dss	61-64	mechanistic target of rapamycin kinase	Mus musculus	28-32
30414942-7	2019	Worsening DSS with increasing TNM status and stage was demonstrated across both typical and atypical carcinoids, with overlaps between adjacent subcategories.	dss	10-13	teneurin transmembrane protein 1	Homo sapiens	30-33
30675212-10	2019	In univariate analysis, EGFR-N overexpression was significantly associated with poorer DSS (P=0.0005), MeFS (P=0.0182), and LRFS (P=0.0014).	dss	87-90	epidermal growth factor receptor	Homo sapiens	24-28
30630536-8	2019	A Cox proportional hazard model of DSS showed smoking status and eGFR expression to be dependent of each other on predicting 5-year DSS.	dss	35-38	epidermal growth factor receptor	Homo sapiens	65-69
30630536-8	2019	A Cox proportional hazard model of DSS showed smoking status and eGFR expression to be dependent of each other on predicting 5-year DSS.	dss	132-135	epidermal growth factor receptor	Homo sapiens	65-69
30630536-10	2019	CONCLUSIONS: Total EGFR tumor levels are predictive of 5-year DSS.	dss	62-65	epidermal growth factor receptor	Homo sapiens	19-23
31155592-5	2019	Blood levels of interleukin-6, tumor necrosis factor-alpha, hydrogen peroxide (H2O2), and iron were elevated in DSS-treated mice but lowered by high-dose vitamin C administration.	dss	112-115	interleukin 6	Mus musculus	16-58
30600646-5	2019	High parenchymal CD8+ T-cell density at the invading tumor edge was associated with improved overall survival (OS) and disease-specific survival (DSS; P &lt; 0.01 and P &lt; 0.01, respectively).	dss	146-149	CD8a molecule	Homo sapiens	17-20
30215718-8	2019	Recombinant PLP partially recapitulated the effect of the whole strain in a rat DSS model.	dss	80-83	parathyroid hormone-like hormone	Rattus norvegicus	12-15
30219846-12	2019	In DSS-induced colitis, systemic delivery of pSin-EF2-ELMO1-Pur attenuated colonic inflammation and promoted recovery from colonic injury.	dss	3-6	engulfment and cell motility 1	Mus musculus	54-59
30219846-14	2019	Conclusions: ELMO1 protects against DSS-induced colonic injury in mice through its effect on epithelial migration via Rac1 activation.	dss	36-39	engulfment and cell motility 1	Mus musculus	13-18
30219846-14	2019	Conclusions: ELMO1 protects against DSS-induced colonic injury in mice through its effect on epithelial migration via Rac1 activation.	dss	36-39	Rac family small GTPase 1	Mus musculus	118-122
30108164-5	2019	Upon AOM and DSS treatment, KLF4 expression was progressively lost in colonic tissues of Klf4fl/fl mice during tumor development.	dss	13-16	Kruppel-like factor 4 (gut)	Mus musculus	28-32
31527366-7	2019	DSS treatment upregulated TRPV4 expression in vascular endothelia of colonic mucosa and submucosa.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	26-31
31527366-8	2019	DSS treatment increased vascular permeability, which was abolished in TRPV4KO mice.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	70-75
30466948-8	2019	Additionally, expression of hTERT was found to be a significant predictor of worse DSS (p = 0.012) in the univariate analysis.	dss	83-86	telomerase reverse transcriptase	Homo sapiens	28-33
30466948-12	2019	Also, hTERT may be a novel poor prognostic indicator of DSS, if the patients are followed for more prolonged time periods.	dss	56-59	telomerase reverse transcriptase	Homo sapiens	6-11
30697362-14	2018	Lunasin dose 20 mg/kg BW and 40 mg/kg BW were able to inhibit inflammation and decrease the expression of COX-2 in colon induced by DSS.	dss	132-135	cytochrome c oxidase II, mitochondrial	Mus musculus	106-111
30619339-5	2018	Results: After induction of DSS colitis, IL13RA2 KO mice had similar disease severity, but recovered more rapidly than WT animals.	dss	28-31	interleukin 13 receptor, alpha 2	Mus musculus	41-48
30547767-8	2018	Kaplan-Meier survival analysis confirmed negative PR result was significantly associated with poorer disease-free survival (DFS) and disease-specific survival (DSS) (both P &lt; 0.001).	dss	160-163	progesterone receptor	Homo sapiens	50-52
30547767-10	2018	After multivariable cox analysis, negative PR result remained an independent prognostic factor for SPNP (DFS HR: 14.50, 95% CI: 1.98-106.05, P = 0.008; DSS HR: 9.15, 95% CI: 1.89-44.17, P = 0.006).	dss	152-155	progesterone receptor	Homo sapiens	43-45
30527251-5	2018	In patients with PTC, the 10-year DSS rates of stages I, II, III, and IV disease in TNM-8 were 99.6%, 95.7%, 81.5%, and 54.8%, respectively; the corresponding rates in TNM-7 were 99.6%, 98.4%, 98.4%, and 90.1%, respectively.	dss	34-37	teneurin transmembrane protein 1	Homo sapiens	84-87
30527251-5	2018	In patients with PTC, the 10-year DSS rates of stages I, II, III, and IV disease in TNM-8 were 99.6%, 95.7%, 81.5%, and 54.8%, respectively; the corresponding rates in TNM-7 were 99.6%, 98.4%, 98.4%, and 90.1%, respectively.	dss	34-37	teneurin transmembrane protein 1	Homo sapiens	168-171
30527251-6	2018	In patients with FTC, the 10-year DSS rates of stages I, II, III, and IV disease in TNM-8 were 97.2%, 69.8%, 50.0%, and 45.5%, respectively; the corresponding rates in TNM-7 were 98.3%, 90.0%, 92.3%, and 42.1%, respectively.	dss	34-37	teneurin transmembrane protein 1	Homo sapiens	84-87
30527251-6	2018	In patients with FTC, the 10-year DSS rates of stages I, II, III, and IV disease in TNM-8 were 97.2%, 69.8%, 50.0%, and 45.5%, respectively; the corresponding rates in TNM-7 were 98.3%, 90.0%, 92.3%, and 42.1%, respectively.	dss	34-37	teneurin transmembrane protein 1	Homo sapiens	168-171
30527251-8	2018	CONCLUSION: Our study suggests that the changes in TNM-8 have improved the clinical usefulness of the TNM staging system in terms of predicting DSS in patients with PTC but not FTC.	dss	144-147	teneurin transmembrane protein 1	Homo sapiens	51-54
30527251-8	2018	CONCLUSION: Our study suggests that the changes in TNM-8 have improved the clinical usefulness of the TNM staging system in terms of predicting DSS in patients with PTC but not FTC.	dss	144-147	teneurin transmembrane protein 1	Homo sapiens	102-105
30466215-9	2018	In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS.	dss	99-102	prostaglandin-endoperoxide synthase 2	Mus musculus	20-25
30466215-9	2018	In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS.	dss	99-102	glial fibrillary acidic protein	Mus musculus	32-36
30466215-9	2018	In the hippocampus, COX-2 mRNA, GFAP mRNA, and GFAP expression were upregulated during exposure to DSS.	dss	99-102	glial fibrillary acidic protein	Mus musculus	47-51
30466215-12	2018	CRP and corticosterone expression increased with DSS treatment at day 7.	dss	49-52	C-reactive protein, pentraxin-related	Mus musculus	0-3
30466215-14	2018	Stress-related hormones and serum inflammatory markers, such as CRP, were upregulated from the third day of DSS treatment.	dss	108-111	C-reactive protein, pentraxin-related	Mus musculus	64-67
30477228-8	2018	The coexpression of higher MAP1LC3B and SQSTM1 demonstrated a significantly worse disease-specific survival (DSS) and disease-free survival (DFS) in patients with BMSCC and LSCC, but not TSCC.	dss	109-112	microtubule associated protein 1 light chain 3 beta	Homo sapiens	27-35
30477228-8	2018	The coexpression of higher MAP1LC3B and SQSTM1 demonstrated a significantly worse disease-specific survival (DSS) and disease-free survival (DFS) in patients with BMSCC and LSCC, but not TSCC.	dss	109-112	sequestosome 1	Homo sapiens	40-46
30195028-7	2018	Consequently, Adrb2-/- animals were more susceptible to L. monocytogenes infection and to intestinal inflammation in a dextran sodium sulfate (DSS) model of colitis.	dss	143-146	adrenoceptor beta 2	Homo sapiens	14-19
29969845-4	2018	This study, based on the dextran sulphate sodium (DSS)-induced colitis model, revealed that Treg cells are significantly increased in PPs, along with CD11b+ B-cell induction.	dss	50-53	integrin subunit alpha M	Homo sapiens	150-155
30105513-11	2018	In multivariable analysis, cases with high LSD1 expression displayed significantly better DSS and DFS (HR 0.477, 95% confidence interval: 0.247-0.923) adjusted for pathological TNM stage.	dss	90-93	lysine demethylase 1A	Homo sapiens	43-47
29726012-9	2018	Nevertheless, multivariate analysis revealed that RAD50 pathogenic mutations were an independent unfavourable predictor of recurrence-free survival (RFS) [adjusted hazard ratio (HR) 2.66; 95% CI, 1.18-5.98; p = 0.018] and disease-specific survival (DSS; adjusted HR 4.36; 95% CI, 1.58-12.03; p = 0.004) in the entire study cohort.	dss	249-252	RAD50 double strand break repair protein	Homo sapiens	50-55
30171165-4	2018	Depletion of neutrophils resulted in more severe colitis in mice because of decreased AREG production by IECs upon dextran sodium sulfate (DSS) insult.	dss	139-142	amphiregulin	Mus musculus	86-90
30287880-6	2018	In multivariate analysis, TP53 mutations in L3 and loop-sheet helix (LSH) associated with a risk ratio (RR) of disease-specific survival (DSS) of 8.779 (p = 0.022) and a RR of disease-free survival (DFS) of 10.498 (p = 0.011).	dss	138-141	tumor protein p53	Homo sapiens	26-30
30287880-7	2018	In IHC analysis BCL-2 overexpression was associated with inferior DFS (p = 0.002) and DSS (p = 0.002).	dss	86-89	BCL2 apoptosis regulator	Homo sapiens	16-21
30287880-8	2018	DLBCL with BCL-2 and MYC overexpression conferred inferior survival in all patients (DSS, p = 0.038 and DFS, p = 0.011) and in patients with non-GC phenotype (DSS (p = 0.013) and DFS (p = 0.010).	dss	85-88	BCL2 apoptosis regulator	Homo sapiens	11-16
30287880-8	2018	DLBCL with BCL-2 and MYC overexpression conferred inferior survival in all patients (DSS, p = 0.038 and DFS, p = 0.011) and in patients with non-GC phenotype (DSS (p = 0.013) and DFS (p = 0.010).	dss	85-88	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	21-24
30287880-8	2018	DLBCL with BCL-2 and MYC overexpression conferred inferior survival in all patients (DSS, p = 0.038 and DFS, p = 0.011) and in patients with non-GC phenotype (DSS (p = 0.013) and DFS (p = 0.010).	dss	159-162	BCL2 apoptosis regulator	Homo sapiens	11-16
30287880-8	2018	DLBCL with BCL-2 and MYC overexpression conferred inferior survival in all patients (DSS, p = 0.038 and DFS, p = 0.011) and in patients with non-GC phenotype (DSS (p = 0.013) and DFS (p = 0.010).	dss	159-162	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	21-24
30044532-6	2018	Moreover, OTUB1-isoform2 served as an independent negative prognostic predictor for disease-free survival (DFS) and disease-specific survival (DSS).	dss	143-146	OTU deubiquitinase, ubiquitin aldehyde binding 1	Homo sapiens	10-15
29992488-4	2018	AhR activation by 6-formylindolo (3,2-b) carbazole (FICZ) represses the abnormal expression of the Par complex in a mouse model of dextran sulphate sodium (DSS)-induced colitis.	dss	156-159	aryl-hydrocarbon receptor	Mus musculus	0-3
30279225-3	2018	We found and validated mutations in Myo1d as a cause of increased susceptibility to DSS-induced colitis.	dss	84-87	myosin ID	Mus musculus	36-41
30279225-6	2018	These findings demonstrate that MYO1D is needed to maintain epithelial integrity and protect against DSS-induced colitis.	dss	101-104	myosin ID	Mus musculus	32-37
30173891-3	2018	Here we show that IEC-specific COOH-terminal Src kinase (Csk)-deficient mice (Csk CKO mice) manifested the increased susceptibility to dextran sodium sulfate (DSS)-induced colitis, a model of inflammatory bowel disease.	dss	159-162	c-src tyrosine kinase	Mus musculus	57-60
30173891-3	2018	Here we show that IEC-specific COOH-terminal Src kinase (Csk)-deficient mice (Csk CKO mice) manifested the increased susceptibility to dextran sodium sulfate (DSS)-induced colitis, a model of inflammatory bowel disease.	dss	159-162	c-src tyrosine kinase	Mus musculus	78-81
30173891-4	2018	DSS-treated Csk CKO mice also exhibited the significantly elevated intestinal permeability.	dss	0-3	c-src tyrosine kinase	Mus musculus	12-15
30173891-5	2018	Following DSS treatment, Csk CKO mice exhibited the higher proliferative activity of colonic epithelial cells and the increased number of apoptotic cells in the colon compared with that apparent for control mice.	dss	10-13	c-src tyrosine kinase	Mus musculus	25-28
30173891-6	2018	Moreover, the abundance of the tight junction protein occludin, which regulates cell-cell adhesion as well as epithelial permeability, was markedly reduced in the colon of DSS-treated Csk CKO mice.	dss	172-175	c-src tyrosine kinase	Mus musculus	184-187
29901779-0	2018	Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice.	dss	38-41	coiled-coil domain containing 80	Mus musculus	0-4
29901779-0	2018	Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice.	dss	38-41	coiled-coil domain containing 80	Mus musculus	5-11
29901779-0	2018	Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice.	dss	102-105	coiled-coil domain containing 80	Mus musculus	0-4
29901779-0	2018	Dro1/Ccdc80 inactivation promotes AOM/DSS-induced colorectal carcinogenesis and aggravates colitis by DSS in mice.	dss	102-105	coiled-coil domain containing 80	Mus musculus	5-11
29901779-7	2018	Moreover, Dro1 inactivation aggravates histological signs of acute and chronic DSS-induced colitis, strongly enlarges the size of ulcerative lesions in the intestinal lining, and exacerbates clinical signs and morbidity by DSS.	dss	79-82	coiled-coil domain containing 80	Mus musculus	10-14
29901779-7	2018	Moreover, Dro1 inactivation aggravates histological signs of acute and chronic DSS-induced colitis, strongly enlarges the size of ulcerative lesions in the intestinal lining, and exacerbates clinical signs and morbidity by DSS.	dss	223-226	coiled-coil domain containing 80	Mus musculus	10-14
30237580-4	2018	It is found that knockout of PAR2 severely aggravates the mucosal damage induced by dextran sodium sulfate (DSS) in mouse, which correlated with notable repression of YAP protein in colonic epithelial cells.	dss	108-111	coagulation factor II (thrombin) receptor-like 1	Mus musculus	29-33
30237580-5	2018	Although the cytokine expression is reduced, the damage of colonic crypt is more severe after DSS-induced colitis in PAR2-/- mouse.	dss	94-97	coagulation factor II (thrombin) receptor-like 1	Mus musculus	117-121
30235866-5	2018	Following CAC induction, STAT1-/- mice displayed an accelerated appearance of inflammation and tumor formation, and increased damage and scores on the disease activity index (DAI) as early as 20 days after AOM-DSS exposure compared to their WT counterparts.	dss	210-213	signal transducer and activator of transcription 1	Mus musculus	25-30
29945292-12	2018	IMP ameliorated DSS-induced colitis by PXR/NF-kappaB signalling.	dss	16-19	nuclear receptor subfamily 1, group I, member 2	Mus musculus	39-42
29945292-12	2018	IMP ameliorated DSS-induced colitis by PXR/NF-kappaB signalling.	dss	16-19	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	43-52
29945292-13	2018	CONCLUSIONS AND IMPLICATIONS: IMP acts as a PXR agonist to attenuate DSS-induced colitis by suppression of the NF-kappaB-mediated pro-inflammatory response in a PXR/NF-kappaB-dependent manner.	dss	69-72	nuclear receptor subfamily 1, group I, member 2	Mus musculus	44-47
29907869-7	2018	Similarly, dextran sodium sulfate (DSS) treatment resulted in greater histologic injury in Bves-/- mice.	dss	35-38	blood vessel epicardial substance	Mus musculus	91-95
30127116-9	2018	Results showed that DSS treatment greatly improved the learning and memory deficits of rats with CCH, reduced apoptosis of neurons in the hippocampal CA1, CA3 regions and dentate gyrus, and increased the phosphorylation of PKA, ERK1/2, and CREB in the hippocampus.	dss	20-23	carbonic anhydrase 1	Rattus norvegicus	150-153
30127116-9	2018	Results showed that DSS treatment greatly improved the learning and memory deficits of rats with CCH, reduced apoptosis of neurons in the hippocampal CA1, CA3 regions and dentate gyrus, and increased the phosphorylation of PKA, ERK1/2, and CREB in the hippocampus.	dss	20-23	carbonic anhydrase 3	Rattus norvegicus	155-158
30127116-9	2018	Results showed that DSS treatment greatly improved the learning and memory deficits of rats with CCH, reduced apoptosis of neurons in the hippocampal CA1, CA3 regions and dentate gyrus, and increased the phosphorylation of PKA, ERK1/2, and CREB in the hippocampus.	dss	20-23	mitogen activated protein kinase 3	Rattus norvegicus	228-234
30047999-4	2018	Compared with littermate controls, the miR-15a/16-/- mice exhibited retarded tumour growth and increased sensibility to DSS-induced colitis.	dss	120-123	microRNA 15a	Mus musculus	39-46
29511870-12	2018	The 5-year disease-specific survival rate (DSS) in the stromal PDGFR-beta-positive group was also significantly worse than in the negative group (43 vs. 70%, p = 0.01).	dss	43-46	platelet derived growth factor receptor beta	Homo sapiens	63-73
29511870-14	2018	CONCLUSIONS: Stromal PDGFR-beta expression is negatively associated with DFS and DSS in patients with NSCLC undergoing preoperative chemo- or chemoradiotherapy.	dss	81-84	platelet derived growth factor receptor beta	Homo sapiens	21-31
30134604-7	2018	p62high expression regardless of LC3B, however, showed an even stronger association with shorter DSS (p = 0.015) and was also an independent negative prognostic factor in multivariate analysis (HR = 2.99; 95% CI 1.38-6.52; p = 0.006).	dss	97-100	nucleoporin 62	Homo sapiens	0-3
30061089-4	2018	In this study, we found that increased expression of Mkp-1, Nrf2, and heme oxygenase 1 (Ho-1) was correlated in colonic tissues in patients with ulcerative colitis and Crohn"s disease, as well as wild-type mice with colitis induced by dextran sodium sulfate (DSS).	dss	259-262	dual specificity phosphatase 1	Homo sapiens	53-58
30061089-4	2018	In this study, we found that increased expression of Mkp-1, Nrf2, and heme oxygenase 1 (Ho-1) was correlated in colonic tissues in patients with ulcerative colitis and Crohn"s disease, as well as wild-type mice with colitis induced by dextran sodium sulfate (DSS).	dss	259-262	NFE2 like bZIP transcription factor 2	Homo sapiens	60-64
30061089-4	2018	In this study, we found that increased expression of Mkp-1, Nrf2, and heme oxygenase 1 (Ho-1) was correlated in colonic tissues in patients with ulcerative colitis and Crohn"s disease, as well as wild-type mice with colitis induced by dextran sodium sulfate (DSS).	dss	259-262	heme oxygenase 1	Homo sapiens	70-86
30061089-4	2018	In this study, we found that increased expression of Mkp-1, Nrf2, and heme oxygenase 1 (Ho-1) was correlated in colonic tissues in patients with ulcerative colitis and Crohn"s disease, as well as wild-type mice with colitis induced by dextran sodium sulfate (DSS).	dss	259-262	heme oxygenase 1	Homo sapiens	88-92
30061089-5	2018	Mkp-1-/- mice were more susceptible to DSS-induced colitis with more severe crypt injury and inflammation.	dss	39-42	dual specificity phosphatase 1	Mus musculus	0-5
30126158-7	2018	In the mouse model, oral administration of KM1608 significantly improved DSS-induced colitis symptoms, such as disease activity index (DAI), colon length, and colon weight, as well as suppressed the expression of IL-6, TNF-alpha, and myeloperoxidase (MPO) in the DSS-induced colitis tissues.	dss	73-76	interleukin 6	Mus musculus	213-217
29395019-5	2018	High expression of TLR3 correlated with favorable 5-year overall survival (OS) and disease specific survival (DSS) among patients with ESCC after esophagectomy (p &lt; 0.01).	dss	110-113	toll like receptor 3	Homo sapiens	19-23
29979618-5	2018	DSS consisted of a combination of automated insulin titration, bolus calculation, and CHO treatment advice.	dss	0-3	insulin	Homo sapiens	44-51
29766204-0	2018	Adiponectin administration alleviates DSS-induced colonic inflammation in Caco-2 cells and mice.	dss	38-41	adiponectin, C1Q and collagen domain containing	Homo sapiens	0-11
29766204-2	2018	This study was investigated the effects of adiponectin on dextran sodium sulfate (DSS)-colonic injury, inflammation, apoptosis, and intestinal barrier dysfunction in Caco-2 cell and mice.	dss	82-85	adiponectin, C1Q and collagen domain containing	Homo sapiens	43-54
29766204-5	2018	Meanwhile, adiponectin downregulated colonic IL-1beta and TNF-alpha expressions and regulated apoptosis relative genes to attenuate DSS-induced colonic inflammation and apoptosis.	dss	132-135	adiponectin, C1Q and collagen domain containing	Homo sapiens	11-22
29766204-7	2018	The in vitro data further demonstrated that adiponectin alleviated DSS-induced proinflammatory cytokines production and the increased permeability in Caco-2 cells.	dss	67-70	adiponectin, C1Q and collagen domain containing	Homo sapiens	44-55
29766204-8	2018	CONCLUSION: Adiponectin plays a beneficial role in DSS-induced inflammation via alleviating apoptosis and improving intestinal barrier integrity.	dss	51-54	adiponectin, C1Q and collagen domain containing	Homo sapiens	12-23
29967068-4	2018	By feeding 5% dextran sodium sulfate (DSS) to hMRP8 von Hippel Lindau (Vhl) KO mice, in which HIF-1alpha and HIF-2alpha are constitutively activated in myeloid cells, we found that these mice were highly susceptible to DSS-induced colitis, demonstrating greater body weight loss, increased mortality, faster onset of rectal bleeding, shortened colon length, and increased CD11b- or Gr-1-positive myeloid cells in the colon compared with wild-type (WT) mice.	dss	38-41	ATP binding cassette subfamily C member 11	Homo sapiens	46-51
30097122-12	2018	CONCLUSION: The study successfully demonstrated that Eup ameliorated DSS-induced mice colitis by suppressing inflammation and maintaining the integrity of the intestinal epithelial barrier via AMPK activation.	dss	69-72	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	193-197
29741702-13	2018	Conclusions: To our knowledge this is the first study to derive estimated pooled OS and DSS of mGCT based on a large dataset.	dss	88-91	granulosa cell tumorigenesis 1	Mus musculus	95-99
29845272-6	2018	However, in the DSS model, the STAT4 transcription in CECs, which are the target cells of activated T cells in the gut, was downregulated by baicalin, suggesting that baicalein and baicalin mediated similar STAT expression in different cell types in autoimmune diseases.	dss	16-19	signal transducer and activator of transcription 4	Mus musculus	31-36
30013440-6	2018	The relationships between CDKN3 expression status and clinicopathological parameters, disease-specific survival (DSS), distant metastasis-free survival (DMeFS), and local recurrence-free survival (LRFS) were statistically analyzed.	dss	113-116	cyclin dependent kinase inhibitor 3	Homo sapiens	26-31
30013440-8	2018	In univariate analysis, high expression of CDKN3 predicted worse DSS (P&lt;0.0001), DMeFS (P&lt;0.0001), and LRFS (P&lt;0.0001).	dss	65-68	cyclin dependent kinase inhibitor 3	Homo sapiens	43-48
29871674-8	2018	NS1-BP downregulation was associated with chemoradiotherapeutic resistance and shorter disease-specific survival (DSS) in both the training and validation cohorts.	dss	114-117	influenza virus NS1A binding protein	Homo sapiens	0-6
29871674-12	2018	In ESCC tissues, c-Myc expression was inversely correlated with NS1-BP levels, and was associated with a shorter DSS.	dss	113-116	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	17-22
29989105-8	2018	These results suggest that the UVB eye irradiation-mediated exacerbation of DSS-induced ulcerative colitis depends on IL-17 produced in response to alterations in clock genes.	dss	76-79	interleukin 17A	Mus musculus	118-123
30956748-4	2018	The DSS aims to aid water treatment operation via source water impact analysis.	dss	4-7	activation induced cytidine deaminase	Homo sapiens	16-19
29570431-3	2018	Therefore, we hypothesized that ablation of GRK2 would protect mice from dextran sodium sulfate (DSS)-induced acute colitis.	dss	97-100	G protein-coupled receptor kinase 2	Mus musculus	44-48
29570431-9	2018	However, expression of inflammatory genes was significantly decreased in DSS-treated GRK2+/- mice compared with GRK2+/+.	dss	73-76	G protein-coupled receptor kinase 2	Mus musculus	85-89
29570431-9	2018	However, expression of inflammatory genes was significantly decreased in DSS-treated GRK2+/- mice compared with GRK2+/+.	dss	73-76	G protein-coupled receptor kinase 2	Mus musculus	112-116
29570431-11	2018	Similar to whole body GRK2 heterozygous knockout mice, myeloid-specific knockout of GRK2 was sufficient for the protection from DSS-induced colitis.	dss	128-131	G protein-coupled receptor kinase 2	Mus musculus	84-88
29570431-12	2018	Together our results indicate that deficiency of GRK2 protects mice from DSS-induced colitis and further suggests that the mechanism of this effect is likely via GRK2 regulation of inflammatory genes in the myeloid cells.	dss	73-76	G protein-coupled receptor kinase 2	Mus musculus	49-53
29570431-12	2018	Together our results indicate that deficiency of GRK2 protects mice from DSS-induced colitis and further suggests that the mechanism of this effect is likely via GRK2 regulation of inflammatory genes in the myeloid cells.	dss	73-76	G protein-coupled receptor kinase 2	Mus musculus	162-166
29776391-10	2018	Similarly, the poor prognosis group of 5-gene score showed shorter DSS (p = 0.045) and early RFS (p = 0.023) as well as a significant association with microvascular invasion, tumor size (&gt; 5 cm), elevated AFP levels, and RB1 mutations.	dss	67-70	alpha fetoprotein	Homo sapiens	208-211
29776391-10	2018	Similarly, the poor prognosis group of 5-gene score showed shorter DSS (p = 0.045) and early RFS (p = 0.023) as well as a significant association with microvascular invasion, tumor size (&gt; 5 cm), elevated AFP levels, and RB1 mutations.	dss	67-70	RB transcriptional corepressor 1	Homo sapiens	224-227
29766049-9	2018	This study shows a strong and novel correlation between IL-1alpha expression, microbiota composition, and clinical outcomes of DSS-induced colitis.	dss	127-130	interleukin 1 alpha	Mus musculus	56-65
29766049-10	2018	IMPORTANCE Here, we show a connection between IL-1alpha expression, microbiota composition, and clinical outcomes of DSS-induced colitis.	dss	117-120	interleukin 1 alpha	Mus musculus	46-55
29766049-11	2018	Specifically, we show that the mild colitis symptoms seen in IL-1alpha-deficient mice following administration of DSS are correlated with the unique gut microbiota compositions of the mice.	dss	114-117	interleukin 1 alpha	Mus musculus	61-70
29356044-9	2018	High expression levels of HMGB1 as total (P = 0.0011) and cytoplasmic score (P = 0.0462) were related to a worse disease-specific survival (DSS) in the entire cohort and in the clinicopathological subgroups.	dss	140-143	high mobility group box 1	Homo sapiens	26-31
29068000-2	2018	Recently, we showed that Clec7a-/- mice are resistant against dextran sodium sulfate (DSS)-induced colitis because of regulatory T-cell population expansion in the colon.	dss	86-89	C-type lectin domain family 7, member a	Mus musculus	25-31
29366768-3	2018	AIM OF THE STUDY: This study aimed to verify the interactions by examining the impact of GP on oral pharmacokinetics of ginsenoside Rb1 (Rb1), the dominant protopanoxadiol (PPD)-type ginsenoside in Ginseng, on a dextran sulphate sodium (DSS) induced experimental colitis model which was characterized by gut dysbiosis, and to delineate the underlying mechanisms in vitro.	dss	237-240	RB transcriptional corepressor 1	Homo sapiens	137-140
29661250-7	2018	A low expression level of IDH1 in breast cancer significantly correlated with advanced stage (p = 0.012), lymph node metastasis (p = 0.018), and poor disease-specific survival (DSS) (adjusted hazard ratio (AHR), 1.57, 95% confidence interval (CI), 1.08-2.30; p = 0.02).	dss	177-180	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	26-30
29661250-10	2018	Multivariate Cox regression analysis revealed that the combination of low IDH1 and high snail expression could be an independent risk factor for shorter DSS (AHR, 2.34; 95% CI, 1.32-4.16; p = 0.004) and shorter disease-free survival (AHR, 2.50; 95% CI, 1.39-4.50; p = 0.002) in patients with breast cancer.	dss	153-156	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	74-78
29661250-10	2018	Multivariate Cox regression analysis revealed that the combination of low IDH1 and high snail expression could be an independent risk factor for shorter DSS (AHR, 2.34; 95% CI, 1.32-4.16; p = 0.004) and shorter disease-free survival (AHR, 2.50; 95% CI, 1.39-4.50; p = 0.002) in patients with breast cancer.	dss	153-156	snail family transcriptional repressor 1	Homo sapiens	88-93
29725255-8	2018	Patients with high expression level of AMACR had significantly worse disease-specific survival (DSS), distant metastasis-free survival (DMFS) and local recurrence-free survival (LRFS) (all P&lt;0.0001).	dss	96-99	alpha-methylacyl-CoA racemase	Homo sapiens	39-44
29262695-10	2018	Expression of the inflammatory cytokines interleukin-1Beta, tumour necrosis factor alpha and interleukin-10 in the serum significantly increased with DSS treatment.	dss	150-153	interleukin 1, beta	Gallus gallus	41-58
29262695-10	2018	Expression of the inflammatory cytokines interleukin-1Beta, tumour necrosis factor alpha and interleukin-10 in the serum significantly increased with DSS treatment.	dss	150-153	interleukin 10	Gallus gallus	93-107
29496522-12	2018	In summary, DHT alleviated DSS-induced UC in mice by suppressing pro-inflammatory mediators and regulating RIPs-MLKL-caspase-8 axis.	dss	27-30	mixed lineage kinase domain-like	Mus musculus	112-116
29496522-12	2018	In summary, DHT alleviated DSS-induced UC in mice by suppressing pro-inflammatory mediators and regulating RIPs-MLKL-caspase-8 axis.	dss	27-30	caspase 8	Mus musculus	117-126
29529198-2	2018	A novel PPARgamma agonist (AS002) developed for local action was evaluated ex vivo in biopsies from UC patients and in vivo in mice with low-grade dextran sodium sulfate (DSS)- and trinitrobenzene sulfonic acid (TNBS)-induced colitis.	dss	171-174	peroxisome proliferator activated receptor gamma	Homo sapiens	8-17
29576961-11	2018	With respect to oncological outcomes, preoperative serum albumin level is a significant independent prognostic factor for overall survival (OS), disease-specific survival (DSS) and disease-free survival (DFS).	dss	172-175	albumin	Homo sapiens	57-64
29253460-8	2018	miR-31-3p expression was increased in both TNBS- and DSS-induced colitis and human colonic biopsies from ulcerative colitis, compared with controls.	dss	53-56	microRNA 31	Homo sapiens	0-6
29253460-9	2018	Intracolonic administration of a miR-31-3p chemical inhibitor exacerbated TNBS- and DSS-induced colitis and increased colonic TNF-alpha, CXCL10, and chemokine (C-C motif) ligand 2 (CCL2) mRNA expression.	dss	84-87	microRNA 31	Homo sapiens	33-39
29253460-10	2018	Conversely, overexpression of miR-31-3p ameliorated the severity of DSS-induced colitis.	dss	68-71	microRNA 31	Homo sapiens	30-36
29133078-12	2018	RESULTS: The fecal microbiota of mice that express hREG3A had a significant shift in composition, compared with control mice, with enrichment of Clostridiales (Ruminococcaceae, Lachnospiraceae) and depletion of Bacteroidetes (Prevotellaceae); the TG mice developed less-severe colitis following administration of DSS than control mice, associated with preserved gut barrier integrity and reduced bacterial translocation, epithelial inflammation, and oxidative damage.	dss	313-316	regenerating family member 3 alpha	Homo sapiens	51-57
29133078-13	2018	A similar shift in the composition of the fecal microbiota occurred after a few months in TG mice heterozygous for REG3A that harbored a wild-type maternal microbiota at birth; these mice developed less-severe forms of colitis following DSS administration.	dss	237-240	regenerating islet-derived 3 alpha	Mus musculus	115-120
29133078-14	2018	Cohoused and germ-free mice fed feces from REG3A-TG mice and given DSS developed less-severe forms of colitis and had reduced lipopolysaccharide activation of the toll-like receptor 4 and increased survival times compared with mice not fed feces from REG3A-TG mice.	dss	67-70	toll-like receptor 4	Mus musculus	163-183
29133078-14	2018	Cohoused and germ-free mice fed feces from REG3A-TG mice and given DSS developed less-severe forms of colitis and had reduced lipopolysaccharide activation of the toll-like receptor 4 and increased survival times compared with mice not fed feces from REG3A-TG mice.	dss	67-70	regenerating islet-derived 3 alpha	Mus musculus	251-256
29133078-17	2018	Fecal samples from REG3A-TG mice had lower levels of ROS than feces from control mice during DSS administration.	dss	93-96	regenerating islet-derived 3 alpha	Mus musculus	19-24
29203393-13	2018	Mefv-/- mice had increased epithelial permeability following administration of DSS than control mice, and loss of the tight junction proteins occludin and claudin-2 from intercellular junctions.	dss	79-82	Mediterranean fever	Mus musculus	0-4
29203393-16	2018	CONCLUSIONS: In studies with DSS-induced colitis, we found that pyrin (MEFV) is required for inflammasome activation and IL18 maturation, which promote intestinal barrier integrity and prevent colon inflammation and tumorigenesis.	dss	29-32	Mediterranean fever	Mus musculus	64-69
29203393-16	2018	CONCLUSIONS: In studies with DSS-induced colitis, we found that pyrin (MEFV) is required for inflammasome activation and IL18 maturation, which promote intestinal barrier integrity and prevent colon inflammation and tumorigenesis.	dss	29-32	Mediterranean fever	Mus musculus	71-75
29203393-16	2018	CONCLUSIONS: In studies with DSS-induced colitis, we found that pyrin (MEFV) is required for inflammasome activation and IL18 maturation, which promote intestinal barrier integrity and prevent colon inflammation and tumorigenesis.	dss	29-32	interleukin 18	Mus musculus	121-125
29352002-3	2018	IEC-specific deletion of LKB1 (LKB1DeltaIEC) resulted in an increased susceptibility to dextran sodium sulfate (DSS)-induced colitis and a definitive shift in the composition of the microbial population in the mouse intestine.	dss	112-115	serine/threonine kinase 11	Mus musculus	25-29
29352002-3	2018	IEC-specific deletion of LKB1 (LKB1DeltaIEC) resulted in an increased susceptibility to dextran sodium sulfate (DSS)-induced colitis and a definitive shift in the composition of the microbial population in the mouse intestine.	dss	112-115	serine/threonine kinase 11	Mus musculus	31-43
29352002-4	2018	Importantly, transfer of the microbiota from LKB1DeltaIEC mice was sufficient to confer increased susceptibility to DSS-induced colitis in wild-type recipient mice.	dss	116-119	serine/threonine kinase 11	Mus musculus	45-57
29352002-7	2018	Administration of exogenous IL-18 restored the expression of antimicrobial peptides, corrected the outgrowth of several bacterial genera, and rescued the LKB1DeltaIEC mice from increased sensitivity to DSS challenge.	dss	202-205	interleukin 18	Mus musculus	28-33
29352002-7	2018	Administration of exogenous IL-18 restored the expression of antimicrobial peptides, corrected the outgrowth of several bacterial genera, and rescued the LKB1DeltaIEC mice from increased sensitivity to DSS challenge.	dss	202-205	serine/threonine kinase 11	Mus musculus	154-166
29121459-9	2018	CONCLUSIONS: We demonstrated the prognostic effect of ePNI for DSS in surgically resected pT3-pT4 gastric cancer patients.	dss	63-66	zinc finger protein 135	Homo sapiens	90-93
29433875-9	2018	On univariate analysis, there was a trend for increased CD44 score to predict both worse DSS and OS (hazard ratio = 1.01, 95% confidence interval 1-1.02, P = 0.056), whereas ALDH and EGFR scores did not.	dss	89-92	CD44 molecule (Indian blood group)	Homo sapiens	56-60
29433875-10	2018	Analysis of 74 TCGA STS cases with complete clinical and genomic data revealed that CD44 copy number alterations predicted worse DSS (9.89 months versus 72.5 months, P = 0.007) and a trend for worse OS (14.03 months versus 38.6 months, P = 0.12), whereas ALDH1 and EGFR copy number alteration did not.	dss	129-132	CD44 molecule (Indian blood group)	Homo sapiens	84-88
29433875-11	2018	Multivariate analysis of the combined data sets was consistent with worse DSS among patients with higher CD44 expression.	dss	74-77	CD44 molecule (Indian blood group)	Homo sapiens	105-109
29487008-9	2018	Combining TB and PDC grades into single grading system (high-grade: Bd3 + G2, Bd2 + G3, Bd3 + G3; low-grade: other combinations) was found to have strong correlation with both 5-year DSS and OS (both p &lt; 0.001).	dss	183-186	defensin beta 103B	Homo sapiens	68-71
29487008-9	2018	Combining TB and PDC grades into single grading system (high-grade: Bd3 + G2, Bd2 + G3, Bd3 + G3; low-grade: other combinations) was found to have strong correlation with both 5-year DSS and OS (both p &lt; 0.001).	dss	183-186	defensin beta 4A	Homo sapiens	78-81
29487008-9	2018	Combining TB and PDC grades into single grading system (high-grade: Bd3 + G2, Bd2 + G3, Bd3 + G3; low-grade: other combinations) was found to have strong correlation with both 5-year DSS and OS (both p &lt; 0.001).	dss	183-186	defensin beta 103B	Homo sapiens	88-91
29305856-3	2018	Using a dextran sodium sulfate (DSS)-induced colitis mouse model, we found that DSS down regulated Pht1 gene expression and up regulated Pht2 gene expression in colonic tissue and immune cells.	dss	32-35	solute carrier family 15, member 4	Mus musculus	99-103
29305856-3	2018	Using a dextran sodium sulfate (DSS)-induced colitis mouse model, we found that DSS down regulated Pht1 gene expression and up regulated Pht2 gene expression in colonic tissue and immune cells.	dss	80-83	solute carrier family 15, member 4	Mus musculus	99-103
29305856-4	2018	In contrast, PEPT1 protein was absent from the colonic tissue and immune cells of normal and DSS-treated mice.	dss	93-96	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	13-18
29374263-0	2018	Ceramide Synthase 6 Deficiency Enhances Inflammation in the DSS model of Colitis.	dss	60-63	ceramide synthase 6	Mus musculus	0-19
29374263-4	2018	While CerS6-deficient mice are protected from T cell mediated colitis, in the T cell independent DSS model lack of CerS6 resulted in a more rapid onset of disease symptoms.	dss	97-100	ceramide synthase 6	Mus musculus	115-120
29374263-5	2018	CerS6-deficient mice maintained low levels of C16-ceramide after DSS treatment, but the inflammatory lipid sphingosine-1-phosphate was significantly increased in colon tissue.	dss	65-68	ceramide synthase 6	Mus musculus	0-5
29343614-0	2018	Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.	dss	86-89	suppressor of cytokine signaling 2	Mus musculus	0-34
29343614-0	2018	Suppressor of cytokine signaling 2 (Socs2) deletion protects bone health of mice with DSS-induced inflammatory bowel disease.	dss	86-89	suppressor of cytokine signaling 2	Mus musculus	36-41
29343614-6	2018	Using the dextran sodium sulfate (DSS) model of colitis, we reveal that endogenously elevated GH function in the Socs2-/- mouse protects the skeleton from osteopenia.	dss	34-37	growth hormone	Mus musculus	94-96
29343614-6	2018	Using the dextran sodium sulfate (DSS) model of colitis, we reveal that endogenously elevated GH function in the Socs2-/- mouse protects the skeleton from osteopenia.	dss	34-37	suppressor of cytokine signaling 2	Mus musculus	113-118
29343614-9	2018	In comparison, the trabecular bone of Socs2-deficient mice was partially protected from the adverse effects of DSS.	dss	111-114	suppressor of cytokine signaling 2	Mus musculus	38-43
29343614-11	2018	This protected phenotype was unlikely to be a consequence of improved mucosal health in the DSS-treated Socs2-/- mice but rather a result of unregulated GH signaling directly on bone.	dss	92-95	suppressor of cytokine signaling 2	Mus musculus	104-109
29483826-5	2018	We found that AhR activation by FICZ attenuated the decreased TJ protein expression in the colonic mucosa of the DSS-induced mice.	dss	113-116	aryl-hydrocarbon receptor	Mus musculus	14-17
29483826-6	2018	Further, the increase of both MLC phosphorylation and MLCK expression in the mice with DSS-induced colitis was also significantly inhibited by FICZ induced AhR activation.	dss	87-90	myosin light chain kinase 3	Mus musculus	54-58
29483826-6	2018	Further, the increase of both MLC phosphorylation and MLCK expression in the mice with DSS-induced colitis was also significantly inhibited by FICZ induced AhR activation.	dss	87-90	aryl-hydrocarbon receptor	Mus musculus	156-159
29310604-3	2018	The Nomo-staging system was established via three nomograms based on 1-year, 2-year and 3-year disease specific survival (DSS) Logistic regression analysis of the training set.	dss	122-125	NODAL modulator 1	Homo sapiens	4-8
29310604-9	2018	Kaplan-Meier survival curves of OS and DSS in testing set showed Nomo-staging system performed better in discrimination and gradient monotonicity, and the external validation in SAHZU database also showed distinctly better discrimination.	dss	39-42	NODAL modulator 1	Homo sapiens	65-69
29709917-6	2018	The depletion of CerK enhanced DSS-induced lethal responses without affecting the onset of these responses.	dss	31-34	ceramide kinase	Mus musculus	17-21
29709917-7	2018	In colons from mice treated with 2.5% DSS for 10 d, epithelial damage was significantly enhanced by the depletion of CerK by day 5, whereas decreases in occluding and E-cadherin levels were similar in both mice.	dss	38-41	ceramide kinase	Mus musculus	117-121
29709917-7	2018	In colons from mice treated with 2.5% DSS for 10 d, epithelial damage was significantly enhanced by the depletion of CerK by day 5, whereas decreases in occluding and E-cadherin levels were similar in both mice.	dss	38-41	cadherin 1	Mus musculus	167-177
29709917-8	2018	On day 5, the DSS treatment increased spleen weights and colonic levels of cyclooxygenase-2, but not cytosolic phospholipase A2alpha, and induced a contractile dysfunction in the colons of both mice.	dss	14-17	prostaglandin-endoperoxide synthase 2	Mus musculus	75-91
29709917-9	2018	The DSS-induced increase in the damage activity index score between days 5 and 10 was slightly enhanced and the decrease in this score from day 10 was slower in CerK(-/-) mice than in WT mice.	dss	4-7	ceramide kinase	Mus musculus	161-165
29709917-10	2018	On day 7 after the DSS treatment, spleen weights slightly decreased and increased in WT and CerK(-/-) mice, respectively.	dss	19-22	ceramide kinase	Mus musculus	92-96
29709917-11	2018	These results indicate that the depletion of CerK enhances the pathology of colitis and lethal responses in DSS-treated mice.	dss	108-111	ceramide kinase	Mus musculus	45-49
29053877-2	2018	The present study aimed to elucidate the function and expression of TRPV4 channels in colonic vascular endothelial cells during dextran sulphate sodium (DSS)-induced colitis.	dss	153-156	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	68-73
29053877-3	2018	EXPERIMENTAL APPROACH: The role of TRPV4 channels in the progression of colonic inflammation was examined in a murine DSS-induced colitis model using immunohistochemical analysis, Western blotting and Evans blue dye extrusion assay.	dss	118-121	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	35-40
29053877-4	2018	KEY RESULTS: DSS-induced colitis was significantly attenuated in TRPV4-deficient (TRPV4 KO) as compared to wild-type mice.	dss	13-16	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	65-70
29053877-4	2018	KEY RESULTS: DSS-induced colitis was significantly attenuated in TRPV4-deficient (TRPV4 KO) as compared to wild-type mice.	dss	13-16	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	82-87
29053877-5	2018	Repeated intrarectal administration of GSK1016790A, a TRPV4 agonist, exacerbated the severity of DSS-induced colitis.	dss	97-100	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	54-59
29053877-6	2018	Bone marrow transfer experiments demonstrated the important role of TRPV4 in non-haematopoietic cells for DSS-induced colitis.	dss	106-109	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	68-73
29053877-7	2018	DSS treatment up-regulated TRPV4 expression in the vascular endothelia of colonic mucosa and submucosa.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	27-32
29053877-8	2018	DSS treatment increased vascular permeability, which was abolished in TRPV4 KO mice.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	70-75
29039120-9	2018	After 1998, HER2-positive disease was associated with better DSS (HzR = 0.72, 95% CI 0.56, 0.93).	dss	61-64	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-16
30021192-10	2018	Moreover, HIF-2alpha expression was linked to a good survival benefit in some cancers (B-cell lymphoma and lung adenocarcinoma: OS, multiple myeloma: DSS, breast cancer: distant metastasis-free survival, liposarcoma: distant recurrence-free survival) (all HRs &lt; 1, Ps &lt; 0.05).	dss	150-153	endothelial PAS domain protein 1	Homo sapiens	10-20
30045015-9	2018	RESULTS: The intestinal mucosal barrier damage in S1PR2-/- mice was more severe than in the WT mice, and there were more CD4+T-cells in the colon tissue of DSS-treated S1PR2-/- mice.	dss	156-159	sphingosine-1-phosphate receptor 2	Mus musculus	50-55
30045015-9	2018	RESULTS: The intestinal mucosal barrier damage in S1PR2-/- mice was more severe than in the WT mice, and there were more CD4+T-cells in the colon tissue of DSS-treated S1PR2-/- mice.	dss	156-159	sphingosine-1-phosphate receptor 2	Mus musculus	168-173
30045015-13	2018	In addition, the IFN-gamma that was secreted by CD4+T-cells increased DSS-induced damage of intestinal epithelial cell barrier function.	dss	70-73	interferon gamma	Mus musculus	17-26
30453297-8	2018	Superoxide dismutase, catalase, and glutathione peroxidase activities in the DSS-induced colitis model were significantly enhanced (P &lt; 0.05) in the presence of dietary IRW and IQW.	dss	77-80	catalase	Mus musculus	22-30
30476915-3	2018	This study firstly attempted to investigate the hypothesis that miR-135a alleviates dextran sodium sulfate (DSS)-induced inflammation in colonic cells and potential mechanisms are also studied.	dss	108-111	membrane associated ring-CH-type finger 8	Homo sapiens	64-67
30476915-8	2018	RESULTS: The results showed that DSS markedly downregulated miR-135a expression (P&lt; 0.05) and induced inflammatory response in Caco-2 and HT-29 cells evidenced by the up regulations and productions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) (P&lt; 0.05).	dss	33-36	membrane associated ring-CH-type finger 8	Homo sapiens	60-63
30476915-8	2018	RESULTS: The results showed that DSS markedly downregulated miR-135a expression (P&lt; 0.05) and induced inflammatory response in Caco-2 and HT-29 cells evidenced by the up regulations and productions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) (P&lt; 0.05).	dss	33-36	interleukin 1 beta	Homo sapiens	204-221
30476915-8	2018	RESULTS: The results showed that DSS markedly downregulated miR-135a expression (P&lt; 0.05) and induced inflammatory response in Caco-2 and HT-29 cells evidenced by the up regulations and productions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) (P&lt; 0.05).	dss	33-36	interleukin 1 beta	Homo sapiens	223-231
30476915-8	2018	RESULTS: The results showed that DSS markedly downregulated miR-135a expression (P&lt; 0.05) and induced inflammatory response in Caco-2 and HT-29 cells evidenced by the up regulations and productions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) (P&lt; 0.05).	dss	33-36	tumor necrosis factor	Homo sapiens	237-264
30476915-8	2018	RESULTS: The results showed that DSS markedly downregulated miR-135a expression (P&lt; 0.05) and induced inflammatory response in Caco-2 and HT-29 cells evidenced by the up regulations and productions of interleukin-1beta (IL-1beta) and tumor necrosis factor-alpha (TNF-alpha) (P&lt; 0.05).	dss	33-36	tumor necrosis factor	Homo sapiens	266-275
30476915-9	2018	Transfection with miR-135a mimic significantly alleviated DSS-induced upregulation and productions of IL-1beta and TNF-alpha in Caco-2 and HT-29 cells (P&lt; 0.05).	dss	58-61	membrane associated ring-CH-type finger 8	Homo sapiens	18-21
30476915-9	2018	Transfection with miR-135a mimic significantly alleviated DSS-induced upregulation and productions of IL-1beta and TNF-alpha in Caco-2 and HT-29 cells (P&lt; 0.05).	dss	58-61	interleukin 1 beta	Homo sapiens	102-110
30476915-9	2018	Transfection with miR-135a mimic significantly alleviated DSS-induced upregulation and productions of IL-1beta and TNF-alpha in Caco-2 and HT-29 cells (P&lt; 0.05).	dss	58-61	tumor necrosis factor	Homo sapiens	115-124
30476915-10	2018	STATs were analyzed and miR-135a mimic treatment reversed STAT3 downregulation in DSS-challenged Caco-2 and HT-29 cells compared with the mimic control (P&lt; 0.05).	dss	82-85	membrane associated ring-CH-type finger 8	Homo sapiens	24-27
30476915-10	2018	STATs were analyzed and miR-135a mimic treatment reversed STAT3 downregulation in DSS-challenged Caco-2 and HT-29 cells compared with the mimic control (P&lt; 0.05).	dss	82-85	signal transducer and activator of transcription 3	Homo sapiens	58-63
30476915-11	2018	Also, STAT3 phosphorylation was inhibited in DSS-challenged Caco-2 cells and miR-135a mimic activated STAT3 signal (P&lt; 0.05).	dss	45-48	signal transducer and activator of transcription 3	Homo sapiens	6-11
30476915-11	2018	Also, STAT3 phosphorylation was inhibited in DSS-challenged Caco-2 cells and miR-135a mimic activated STAT3 signal (P&lt; 0.05).	dss	45-48	signal transducer and activator of transcription 3	Homo sapiens	102-107
30476915-13	2018	CONCLUSION: Our results indicated that miR-135a alleviated DSS-induced inflammation and activated STAT3 signal in colonic cells.	dss	59-62	membrane associated ring-CH-type finger 8	Homo sapiens	39-42
30476915-13	2018	CONCLUSION: Our results indicated that miR-135a alleviated DSS-induced inflammation and activated STAT3 signal in colonic cells.	dss	59-62	signal transducer and activator of transcription 3	Homo sapiens	98-103
29423390-11	2018	In contrast, HPD increased DSS-induced colon mucosal hyperplasia, colonocyte proliferation, COX-2 expression, and plasma nitric oxide compared to ND group.	dss	27-30	prostaglandin-endoperoxide synthase 2	Mus musculus	92-97
29038964-12	2018	Cox"s regression showed that CME (p = 0.0012), the number of lymph nodes (p = 0.029), and TNM stage (p &lt; 0.001) were significant independent predictors of DSS at 3 years.	dss	158-161	teneurin transmembrane protein 1	Homo sapiens	90-93
29148173-4	2018	We showed that metformin alleviated dextran sodium sulphate (DSS)-induced decreases in transepithelial electrical resistance, FITC-dextran hyperpermeability, loss of the tight junction (TJ) proteins occludin and ZO-1 and bacterial translocation in Caco-2 cell monolayers or in colitis mice models.	dss	61-64	occludin	Homo sapiens	199-207
29148173-4	2018	We showed that metformin alleviated dextran sodium sulphate (DSS)-induced decreases in transepithelial electrical resistance, FITC-dextran hyperpermeability, loss of the tight junction (TJ) proteins occludin and ZO-1 and bacterial translocation in Caco-2 cell monolayers or in colitis mice models.	dss	61-64	tight junction protein 1	Homo sapiens	212-216
29148173-7	2018	In addition, metformin suppressed DSS-induced JNK activation, an effect dependent on AMP-activated protein kinase alpha1 (AMPKalpha1) activation.	dss	34-37	mitogen-activated protein kinase 8	Homo sapiens	46-49
29148173-7	2018	In addition, metformin suppressed DSS-induced JNK activation, an effect dependent on AMP-activated protein kinase alpha1 (AMPKalpha1) activation.	dss	34-37	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	85-120
29148173-7	2018	In addition, metformin suppressed DSS-induced JNK activation, an effect dependent on AMP-activated protein kinase alpha1 (AMPKalpha1) activation.	dss	34-37	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	122-132
29393221-4	2018	Gut leakage induced by dextran sulfate solution (DSS) or endotoxin administration together with BG or endotoxin alone, but not BG alone, enhanced the severity of cecal ligation and puncture (CLP) sepsis more prominently in 8-week-old FcGRIIb-/- mice.	dss	49-52	hyaluronan and proteoglycan link protein 1	Mus musculus	191-194
29393221-4	2018	Gut leakage induced by dextran sulfate solution (DSS) or endotoxin administration together with BG or endotoxin alone, but not BG alone, enhanced the severity of cecal ligation and puncture (CLP) sepsis more prominently in 8-week-old FcGRIIb-/- mice.	dss	49-52	Fc receptor, IgG, low affinity IIb	Mus musculus	234-241
29115460-3	2018	The aim of the present study was to investigate the function of CRF receptor 1 (CRF-R1) in the development of mucosal inflammation induced by dextran sulphate sodium (DSS) and the underlying mechanism.	dss	167-170	corticotropin releasing hormone receptor 1	Mus musculus	64-78
29115460-3	2018	The aim of the present study was to investigate the function of CRF receptor 1 (CRF-R1) in the development of mucosal inflammation induced by dextran sulphate sodium (DSS) and the underlying mechanism.	dss	167-170	corticotropin releasing hormone receptor 1	Mus musculus	80-86
29115460-4	2018	Consecutive administration of CRF or CP154526 was used to activate or block the CRF-R1 in DSS-treated mice.	dss	90-93	corticotropin releasing hormone receptor 1	Mus musculus	80-86
29115460-9	2018	Thus, CRF-R1 expression was proportional to the severity of DSS-induced colitis.	dss	60-63	corticotropin releasing hormone receptor 1	Mus musculus	6-12
29115460-10	2018	Activation of CRF-R1 increased the DAI and histological scores of the colons from DSS-treated mice by promoting M1 macrophage polarization, demonstrated as increased NF-kappaB activation, and TNF-alpha and IL-6 release.	dss	82-85	corticotropin releasing hormone receptor 1	Mus musculus	14-20
29115460-10	2018	Activation of CRF-R1 increased the DAI and histological scores of the colons from DSS-treated mice by promoting M1 macrophage polarization, demonstrated as increased NF-kappaB activation, and TNF-alpha and IL-6 release.	dss	82-85	tumor necrosis factor	Mus musculus	192-201
29115460-10	2018	Activation of CRF-R1 increased the DAI and histological scores of the colons from DSS-treated mice by promoting M1 macrophage polarization, demonstrated as increased NF-kappaB activation, and TNF-alpha and IL-6 release.	dss	82-85	interleukin 6	Mus musculus	206-210
29115460-11	2018	These results provide evidence of the pro-inflammatory role of CRF-R1 in a DSS-induced ulcerative colitis (UC) model and a possible underlying mechanism, which may facilitate the elucidation of potential treatment approaches for UC.	dss	75-78	corticotropin releasing hormone receptor 1	Mus musculus	63-69
30445455-8	2019	Moreover, in the dextran sodium sulphate (DSS)-induced murine colitis model, the mice grafted with Fut8-/- bone marrow cells exhibited higher resistance to inflammation than those grafted with Fut8+/+ bone marrow cells.	dss	42-45	fucosyltransferase 8	Mus musculus	99-103
30445455-9	2019	These findings indicate that core fucose is essential for CD14-dependent TLR4 and TLR2 signalling in murine macrophage activity, leading to DSS-induced experimental colitis.	dss	140-143	CD14 antigen	Mus musculus	58-62
30445455-9	2019	These findings indicate that core fucose is essential for CD14-dependent TLR4 and TLR2 signalling in murine macrophage activity, leading to DSS-induced experimental colitis.	dss	140-143	toll-like receptor 4	Mus musculus	73-77
30445455-9	2019	These findings indicate that core fucose is essential for CD14-dependent TLR4 and TLR2 signalling in murine macrophage activity, leading to DSS-induced experimental colitis.	dss	140-143	toll-like receptor 2	Mus musculus	82-86
30873029-4	2019	The aim of the present study was to examine the potential protective effects of recombinant PG-1 in a mouse dextran sodium sulfate (DSS)-induced colitis inflammation model.	dss	132-135	protegrin-1	Sus scrofa	92-96
30873029-5	2019	This is the first report showing the protective effects of PG-1 in its various forms (pro-, cathelin-, and mature-forms) in attenuating significant body weight loss associated with DSS-induced colitis (p &lt; 0.05).	dss	181-184	protegrin-1	Sus scrofa	59-63
30881446-13	2019	Conclusion: EA and MB were able to regulate the concentration of CRH in serum and protein expression in the peripheral and central at different levels and promote the recovery of the HPA axis that may be the basis for EA and MB to improve colonic pathology and alleviate anxiety behavior in DSS-induced colitis.	dss	291-294	corticotropin releasing hormone	Mus musculus	65-68
30361882-5	2019	RESULTS: High tumor CD103+ TIL content was associated with significantly improved OS, DSS, and DFS and was a stronger predictor of survival in recurrent/persistent LSCC than either high CD8+ or CD4+ TIL content.	dss	86-89	integrin subunit alpha E	Homo sapiens	20-25
30774010-0	2019	The NLRP3 inflammasome mediates DSS-induced intestinal inflammation in Nod2 knockout mice.	dss	32-35	NLR family, pyrin domain containing 3	Mus musculus	4-9
30774010-0	2019	The NLRP3 inflammasome mediates DSS-induced intestinal inflammation in Nod2 knockout mice.	dss	32-35	nucleotide-binding oligomerization domain containing 2	Mus musculus	71-75
30774010-4	2019	In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice.	dss	150-153	NLR family, pyrin domain containing 3	Mus musculus	69-106
30774010-4	2019	In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice.	dss	150-153	NLR family, pyrin domain containing 3	Mus musculus	108-113
30774010-4	2019	In the present study, MCC950, a specific small molecule inhibitor of NLR pyrin domain-containing protein 3 (NLRP3), abrogated dextran sodium sulfate (DSS)-induced intestinal inflammation in Nod2-/- mice.	dss	150-153	nucleotide-binding oligomerization domain containing 2	Mus musculus	190-194
30774010-5	2019	NLRP3 inflammasome formation was observed at a higher rate in NOD2-deficient small intestinal lamina propria cells after insult by DSS.	dss	131-134	NLR family, pyrin domain containing 3	Mus musculus	0-5
30774010-5	2019	NLRP3 inflammasome formation was observed at a higher rate in NOD2-deficient small intestinal lamina propria cells after insult by DSS.	dss	131-134	nucleotide-binding oligomerization domain containing 2	Mus musculus	62-66
30535144-9	2019	Increased numbers of infiltrating MPhis and neutrophils, but not CD3+ T cells, were observed in DSS-treated TDAG8-/- mice.	dss	96-99	G-protein coupled receptor 65	Mus musculus	108-113
30483954-7	2019	In univariate analysis, high expression levels of AR were associated with reduced RFS (HR 2.8, p = 0.015) and DSS (HR 2.8, p = 0.010).	dss	110-113	androgen receptor	Homo sapiens	50-52
30483954-8	2019	High AR mRNA expression and a positive lymph node status were independent predictors for reduced RFS (HR 2.5, p = 0.0049) and DSS (HR 3.4, p = 0.009).	dss	126-129	androgen receptor	Homo sapiens	5-7
30483954-9	2019	In patients with low AR mRNA expression, an increased ESR1 and PGR mRNA expression were associated with reduced RFS and DSS.	dss	120-123	androgen receptor	Homo sapiens	21-23
30483954-9	2019	In patients with low AR mRNA expression, an increased ESR1 and PGR mRNA expression were associated with reduced RFS and DSS.	dss	120-123	estrogen receptor 1	Homo sapiens	54-58
30483954-9	2019	In patients with low AR mRNA expression, an increased ESR1 and PGR mRNA expression were associated with reduced RFS and DSS.	dss	120-123	progesterone receptor	Homo sapiens	63-66
30483954-11	2019	ESR1 and PGR expression status can further stratify patients with low AR expression into subgroups with significantly reduced RFS and DSS.	dss	134-137	estrogen receptor 1	Homo sapiens	0-4
30483954-11	2019	ESR1 and PGR expression status can further stratify patients with low AR expression into subgroups with significantly reduced RFS and DSS.	dss	134-137	progesterone receptor	Homo sapiens	9-12
30483954-11	2019	ESR1 and PGR expression status can further stratify patients with low AR expression into subgroups with significantly reduced RFS and DSS.	dss	134-137	androgen receptor	Homo sapiens	70-72
31012674-3	2019	We show that each piece of DSS carries a half-integer topological charge, which for systems containing two pieces of DSS yield a net Chern number C=-1.	dss	27-30	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	146-150
31012674-3	2019	We show that each piece of DSS carries a half-integer topological charge, which for systems containing two pieces of DSS yield a net Chern number C=-1.	dss	117-120	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	146-150
31645121-10	2019	In dextran sulfated sodium (DSS)-induced colitis mice model, RSBE restored body weight, colon length, and the levels of pro-inflammatory cytokines, such as TNF-alpha, IL-6, interleukin-1beta (IL-1beta), and interferon-gamma (IFN-gamma).	dss	28-31	interleukin 1 beta	Mus musculus	173-190
31366877-5	2019	The arthritis/DSS-treated mice did not demonstrate changes in hind foot volumes or in the concentration of matrix metalloproteinase-3 (MMP-3) in the plasma; however, plasma levels of interleukin-6 (IL-6) and tumor necrosis factor (TNF)-alpha were increased.	dss	14-17	interleukin 6	Mus musculus	183-196
30144315-16	2019	In conclusion, PP significantly ameliorated murine DSS-induced UC model, via regulation of MAPKs and NF-kappaB pathways in DCs.	dss	51-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	101-110
30219846-0	2019	Engulfment and Cell Motility Protein 1 Protects Against DSS-induced Colonic Injury in Mice via Rac1 Activation.	dss	56-59	engulfment and cell motility 1	Mus musculus	0-38
30219846-0	2019	Engulfment and Cell Motility Protein 1 Protects Against DSS-induced Colonic Injury in Mice via Rac1 Activation.	dss	56-59	Rac family small GTPase 1	Mus musculus	95-99
31527366-2	2019	The present study aimed to elucidate the expression of TRPV4 in the gastrointestinal tract and the pathogenic roles of TRPV4 in dextran sulphate sodium (DSS)-induced colitis.	dss	153-156	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	55-60
31527366-2	2019	The present study aimed to elucidate the expression of TRPV4 in the gastrointestinal tract and the pathogenic roles of TRPV4 in dextran sulphate sodium (DSS)-induced colitis.	dss	153-156	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	119-124
31527366-6	2019	DSS-induced colitis was significantly attenuated in TRPV4-knockout (TRPV4KO) mice when compared to wild-type mice.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	52-57
30523270-8	2018	Piwi-like 2 positivity was associated with DSS (P = 0.008) and recurrence-free survival (RFS; P = 0.040), and in multivariate Cox"s analysis, Piwi-like 2 positivity was an independent prognostic factor for DSS (RR = 2.46; P = 0.004) and RFS (RR = 3.0; P = 0.003).	dss	43-46	piwi like RNA-mediated gene silencing 2	Homo sapiens	0-11
30523270-8	2018	Piwi-like 2 positivity was associated with DSS (P = 0.008) and recurrence-free survival (RFS; P = 0.040), and in multivariate Cox"s analysis, Piwi-like 2 positivity was an independent prognostic factor for DSS (RR = 2.46; P = 0.004) and RFS (RR = 3.0; P = 0.003).	dss	206-209	piwi like RNA-mediated gene silencing 2	Homo sapiens	142-153
30523270-9	2018	Most interestingly, in the basal type patient subgroup (CK5+/GATA3-), Piwi-like 2 positivity was associated with poorer DSS, OS and RFS (P &lt; 0.001, P = 0.004 and P = 0.05; log rank test).	dss	120-123	piwi like RNA-mediated gene silencing 2	Homo sapiens	70-81
30523270-10	2018	In multivariate analysis, Piwi-like 2 positivity was an independent prognostic factor for DSS (RR = 12.70; P = 0.001), OS (RR = 6.62;  = 0.008) and RFS (RR=13.0; P = 0.040).	dss	90-93	piwi like RNA-mediated gene silencing 2	Homo sapiens	26-37
30188752-7	2018	Thus, our research shows that GDF11 alleviates DSS-induced colitis by inhibiting NLRP3 inflammasome activation, providing some basis for its potential use in the treatment of UC.	dss	47-50	NLR family, pyrin domain containing 3	Mus musculus	81-86
30372880-7	2018	The administration of AJE also inhibits DSS-induced pro-inflammatory cytokines expression, including interleukin (IL)-1beta, IL-6, tumor necrosis factor (TNF)-alpha, and cyclooxygenase (COX)-2.	dss	40-43	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	170-192
30225764-5	2018	We also found significant activation of microglial cells and reduction in occludin and claudin-5 expression in the brain tissue after DSS-induced colitis.	dss	134-137	occludin	Mus musculus	74-82
30225764-5	2018	We also found significant activation of microglial cells and reduction in occludin and claudin-5 expression in the brain tissue after DSS-induced colitis.	dss	134-137	claudin 5	Mus musculus	87-96
30270609-9	2018	lactis strain BB12 could protect against the development of colitis in a DSS-induced mouse model of UC.	dss	73-76	B.burgdorferi-associated arthritis 12	Mus musculus	14-18
30270609-10	2018	In the present study, oral administration of BB12 markedly ameliorated DSS-induced colitis, accompanied by reduced tumor necrosis factor-alpha-mediated IEC apoptosis.	dss	71-74	B.burgdorferi-associated arthritis 12	Mus musculus	45-49
30270609-11	2018	These findings indicate that the probiotic strain BB12 can alleviate DSS-induced colitis and suggest a novel mechanism of communication between probiotic microorganisms and intestinal epithelia, which increases intestinal cell survival by modulating pro-apoptotic cytokine expression.	dss	69-72	B.burgdorferi-associated arthritis 12	Mus musculus	50-54
30662599-1	2018	In a previous study using a rat model of focal cerebral ischemia/reperfusion (I/R) injury, we found that 3"-Daidzein sulfonate sodium (DSS), a derivative of daidzein, exerts neuroprotective effects by alleviating brain edema and reducing levels of interleukin (IL)-6.	dss	135-138	interleukin 6	Rattus norvegicus	248-266
30662599-4	2018	Moreover, treatment with DSS significantly reduced the levels of IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in serum and in the ischemic penumbra.	dss	25-28	interleukin 1 beta	Rattus norvegicus	65-73
30662599-4	2018	Moreover, treatment with DSS significantly reduced the levels of IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in serum and in the ischemic penumbra.	dss	25-28	interleukin 6	Rattus norvegicus	75-79
30662599-4	2018	Moreover, treatment with DSS significantly reduced the levels of IL-1beta, IL-6, and tumor necrosis factor (TNF)-alpha in serum and in the ischemic penumbra.	dss	25-28	tumor necrosis factor	Rattus norvegicus	85-118
30400733-9	2018	In addition, the mRNA expression levels of intestinal barrier-related molecules (i.e., MUC2, ZO-1, OCLN, and CLDN4) were decreased by AOM/DSS-treatment; furthermore, this inhibition was rescued by E2 supplementation.	dss	138-141	mucin 2	Mus musculus	87-91
30400733-9	2018	In addition, the mRNA expression levels of intestinal barrier-related molecules (i.e., MUC2, ZO-1, OCLN, and CLDN4) were decreased by AOM/DSS-treatment; furthermore, this inhibition was rescued by E2 supplementation.	dss	138-141	tight junction protein 1	Mus musculus	93-97
30400733-9	2018	In addition, the mRNA expression levels of intestinal barrier-related molecules (i.e., MUC2, ZO-1, OCLN, and CLDN4) were decreased by AOM/DSS-treatment; furthermore, this inhibition was rescued by E2 supplementation.	dss	138-141	occludin	Mus musculus	99-103
30400733-9	2018	In addition, the mRNA expression levels of intestinal barrier-related molecules (i.e., MUC2, ZO-1, OCLN, and CLDN4) were decreased by AOM/DSS-treatment; furthermore, this inhibition was rescued by E2 supplementation.	dss	138-141	claudin 4	Mus musculus	109-114
30400733-10	2018	The mRNA and protein expression of inflammation-related genes (i.e., KLF4, NF-kappaB, iNOS, and COX-2) was increased by AOM/DSS-treatment and ameliorated by E2.	dss	124-127	Kruppel-like factor 4 (gut)	Mus musculus	69-73
30400733-10	2018	The mRNA and protein expression of inflammation-related genes (i.e., KLF4, NF-kappaB, iNOS, and COX-2) was increased by AOM/DSS-treatment and ameliorated by E2.	dss	124-127	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
30400733-10	2018	The mRNA and protein expression of inflammation-related genes (i.e., KLF4, NF-kappaB, iNOS, and COX-2) was increased by AOM/DSS-treatment and ameliorated by E2.	dss	124-127	nitric oxide synthase 2, inducible	Mus musculus	86-90
30400733-10	2018	The mRNA and protein expression of inflammation-related genes (i.e., KLF4, NF-kappaB, iNOS, and COX-2) was increased by AOM/DSS-treatment and ameliorated by E2.	dss	124-127	cytochrome c oxidase II, mitochondrial	Mus musculus	96-101
30419851-6	2018	RESULTS: In the entire cohort, 5y Disease Specific Survival (DSS) was 97.1 and 84% for AC and SCC respectively (p = 0.150).	dss	61-64	serpin family B member 3	Homo sapiens	94-97
30419851-7	2018	In the NA-CRT group 5y DSS was 100 and 75.5% for AC and SCC respectively (p = 0.059).	dss	23-26	serpin family B member 3	Homo sapiens	56-59
29917067-12	2018	In addition, E-cadherin deletion in CD11c+ cells attenuated colitis in both CD11c-cre Tgfbr2fl/fl and DSS-treated mice.	dss	102-105	cadherin 1	Homo sapiens	13-23
29917067-12	2018	In addition, E-cadherin deletion in CD11c+ cells attenuated colitis in both CD11c-cre Tgfbr2fl/fl and DSS-treated mice.	dss	102-105	integrin subunit alpha X	Homo sapiens	36-41
30218243-10	2018	TNM stage was the only independent predictor of DSS for both cohorts.	dss	48-51	teneurin transmembrane protein 1	Homo sapiens	0-3
30218243-11	2018	CONCLUSIONS: Patients &gt;= 80 years of age selected for gastrectomy for GC at MSKCC and FMUUH had acceptable morbidity and mortality, and DSS was primarily dependent on TNM stage.	dss	139-142	teneurin transmembrane protein 1	Homo sapiens	170-173
30159726-7	2018	Survival analysis demonstrated that patients with pN0 to pN1 had better OS (P = 0.02), disease-specific survival (DSS) (P = 0.003), DFS (P = 0.02) and metastases free survival (MFS) (P = 0.002) compared to patients with pN2 to pN3.	dss	114-117	serpin family E member 2	Homo sapiens	57-60
30303590-6	2018	Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P &lt; .05 each).	dss	123-126	solute carrier family 7 member 11	Homo sapiens	56-59
30303590-6	2018	Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P &lt; .05 each).	dss	123-126	solute carrier family 7 member 11	Homo sapiens	69-72
30303590-6	2018	Multivariate analysis indicated that high expression of xCT and both xCT and CD44 were independent predictors of poor RFS, DSS, and OS (P &lt; .05 each).	dss	123-126	CD44 molecule (Indian blood group)	Homo sapiens	77-81
30047135-10	2018	The loss of cadherin-17 resulted in increased permeability and susceptibility to DSS-induced colitis.	dss	81-84	cadherin 17	Mus musculus	12-23
30047135-11	2018	The AOM/DSS model demonstrated that Cdh17 KO enhanced tumour formation and progression in the intestine.	dss	8-11	cadherin 17	Mus musculus	36-41
30402236-8	2018	Factors associated with DSS were cN positive (HR=4.55, P&lt;0.01), pN positive (HR=3.40, P&lt;0.05), higher preoperative serum carcinoembryonic antigen (CEA) (HR=3.04, P&lt;0.05), and hormone receptor negative (HR=2.32, P&lt;0.05).	dss	24-27	CEA cell adhesion molecule 3	Homo sapiens	127-151
30402236-8	2018	Factors associated with DSS were cN positive (HR=4.55, P&lt;0.01), pN positive (HR=3.40, P&lt;0.05), higher preoperative serum carcinoembryonic antigen (CEA) (HR=3.04, P&lt;0.05), and hormone receptor negative (HR=2.32, P&lt;0.05).	dss	24-27	CEA cell adhesion molecule 3	Homo sapiens	153-156
30402236-9	2018	In the hormone receptor positive HER2 negative, cN-positive/pN-positive breast cancer group, RFS and DSS were poorer compared with the other groups.	dss	101-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	33-37
30409319-7	2018	When the modified-TNM was applied, DSS curves between stage groups significantly differed (p < 0.001), and the relative risk of DSS in stage IIB patients was 2.3 times higher than in stage IIA patients (p < 0.001).	dss	35-38	teneurin transmembrane protein 1	Homo sapiens	18-21
30409319-7	2018	When the modified-TNM was applied, DSS curves between stage groups significantly differed (p < 0.001), and the relative risk of DSS in stage IIB patients was 2.3 times higher than in stage IIA patients (p < 0.001).	dss	128-131	teneurin transmembrane protein 1	Homo sapiens	18-21
30277770-3	2018	The whole powder ameliorated the DSS-induced body weight loss (body weight changes on day 9, Control 108 +- 2, DSS 91 +- 4, DSS+whole peel powder 106 +- 1%, p &lt; 0.05), colon shortening (colon length, Control 5.0 +- 0.1, DSS 3.9 +- 0.1, DSS+whole peel powder 4.7 +- 0.1 cm, p &lt; 0.05), increased expression of pro-inflammatory cytokines (e.g., TNF-alpha, Control 1.0 +- 0.1, DSS 22.2 +- 5.8, DSS+whole peel powder 4.3 +- 1.5 arbitrary unit, p &lt; 0.05), and decreased expression of colonic tight junctions (TJs) (e.g., occludin, Control 1.00 +- 0.07, DSS 0.21 +- 0.07, DSS+whole peel powder 0.70 +- 0.06 arbitrary unit, p &lt; 0.05).	dss	33-36	tumor necrosis factor	Mus musculus	348-357
30312415-2	2018	The noncanonical inflammasome activator caspase-11 (Casp11) reportedly attenuates acute dextran sodium sulfate (DSS) colitis in mice.	dss	112-115	caspase 4, apoptosis-related cysteine peptidase	Mus musculus	40-50
30312415-2	2018	The noncanonical inflammasome activator caspase-11 (Casp11) reportedly attenuates acute dextran sodium sulfate (DSS) colitis in mice.	dss	112-115	caspase 4, apoptosis-related cysteine peptidase	Mus musculus	52-58
30312415-13	2018	Conclusions: Casp11 does not impact chronic experimental colitis, and its effects on acute DSS colitis vary with environmental factors including the microbiota, particularly Clostridiales.	dss	91-94	caspase 4, apoptosis-related cysteine peptidase	Mus musculus	13-19
30392254-6	2018	The 5-years disease-specific survival (DSS) in down HMGCS2 expression group (14 months) was poorer than those in normal expression group (20 months; P=0.002).	dss	39-42	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	52-58
30392254-7	2018	In addition, multivariate Cox regression analysis showed that HMGCS2 expression (Wald=7.136, P=0.008) was an independent risk factor for DSS.	dss	137-140	3-hydroxy-3-methylglutaryl-CoA synthase 2	Homo sapiens	62-68
30224451-4	2018	Unlike those previously published studies, we focused on the functional role of IL-33/ST2 during an extended (2-wk) recovery period after initial challenge in dextran sodium sulfate (DSS)-induced colitic mice.	dss	183-186	interleukin 33	Mus musculus	80-85
30224451-6	2018	Mechanistically, we show that IL-33 stimulates the expression of a network of microRNAs (miRs) in the Caco2 colonic intestinal epithelial cell (IEC) line, especially miR-320, which is increased by &gt;16-fold in IECs isolated from IL-33-treated vs. vehicle-treated DSS colitic mice.	dss	265-268	interleukin 33	Homo sapiens	30-35
30224451-6	2018	Mechanistically, we show that IL-33 stimulates the expression of a network of microRNAs (miRs) in the Caco2 colonic intestinal epithelial cell (IEC) line, especially miR-320, which is increased by &gt;16-fold in IECs isolated from IL-33-treated vs. vehicle-treated DSS colitic mice.	dss	265-268	microRNA 320	Mus musculus	166-173
29987099-8	2018	In conclusion, men with HPV or p16-positive penile cancer have a significantly more favorable DSS compared with men with HPV or p16-negative penile cancer.	dss	94-97	cyclin dependent kinase inhibitor 2A	Homo sapiens	31-34
29633104-4	2018	As expected, the DSS ingestion damaged the colonic tissue, lowered the body weight, decreased the mucin levels, increased MPO activity, reduced SOD activity and GSH amount.	dss	17-20	myeloperoxidase	Mus musculus	122-125
30006753-10	2018	E-cadherin-low PCa patients displayed worse disease-specific survival (DSS), although not reaching statistical significance (HR 2.65, 95%CI 0.81-7.88).	dss	71-74	cadherin 1	Homo sapiens	0-10
30006753-11	2018	However, considering the pT3b group only, those with low E-cadherin immunoexpression displayed significantly worse overall-survival (OS) and DSS (HR 3.69, 95%CI 1.18-11.50; HR 5.90, 95%CI 1.40-24.81).	dss	141-144	cadherin 1	Homo sapiens	57-67
30338217-5	2018	Histopathological analysis showed extensive damage to the colon mucosa in DSS-treated CD11c-Cre+Rab32f/f mice, including more severe damage to the epithelial layer and crypts, as well as more inflammatory cell infiltration.	dss	74-77	integrin alpha X	Mus musculus	86-91
30338217-8	2018	The present data demonstrate that Rab32 knockout in CD11c+ cells aggravates the development of DSS-induced colitis and suggest that the Rab32-related antimicrobial pathway is involved in the pathogenesis of IBD.	dss	95-98	RAB32, member RAS oncogene family	Homo sapiens	34-39
30338217-8	2018	The present data demonstrate that Rab32 knockout in CD11c+ cells aggravates the development of DSS-induced colitis and suggest that the Rab32-related antimicrobial pathway is involved in the pathogenesis of IBD.	dss	95-98	integrin subunit alpha X	Homo sapiens	52-57
30338217-8	2018	The present data demonstrate that Rab32 knockout in CD11c+ cells aggravates the development of DSS-induced colitis and suggest that the Rab32-related antimicrobial pathway is involved in the pathogenesis of IBD.	dss	95-98	RAB32, member RAS oncogene family	Homo sapiens	136-141
30232010-4	2018	Rnf5-/- mice exhibit severe acute colitis following dextran sodium sulfate (DSS) treatment.	dss	76-79	ring finger protein 5	Mus musculus	0-4
30232010-7	2018	Administration of S100A8-neutralizing antibodies to DSS-treated Rnf5-/- mice attenuates acute colitis development and increases survival.	dss	52-55	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	18-24
30232010-7	2018	Administration of S100A8-neutralizing antibodies to DSS-treated Rnf5-/- mice attenuates acute colitis development and increases survival.	dss	52-55	ring finger protein 5	Mus musculus	64-68
30233214-4	2018	Based on Cox models, a nomogram was constructed to predict the probabilities of OS and DSS for an individual patient.	dss	87-90	cytochrome c oxidase subunit 8A	Homo sapiens	9-12
29971670-5	2018	RESULTS: Preoperative CEA/CA19-9 levels were identified as an independent predictor of overall survival (OS) and disease-specific survival (DSS) (both p &lt; 0.05) in the development group.	dss	140-143	CEA cell adhesion molecule 3	Homo sapiens	22-25
29971670-10	2018	CONCLUSION: Preoperative CEA/CA19-9 levels are an independent predictor of OS and DSS in stage III GC patients.	dss	82-85	CEA cell adhesion molecule 3	Homo sapiens	25-28
29885403-5	2018	Using stromal TIL score as a stepwise discrete variable, increasing survival was seen with rising TIL level: disease-specific survival (DSS; P = .008), overall survival (P = .036) and disease-free survival (P = .006).	dss	136-139	toll like receptor 1	Homo sapiens	98-101
30395870-7	2018	We subjected mice with dextran sodium sulfate (DSS)-induced colitis to gene therapy using a vector that overexpressed Ro60 threefold.	dss	47-50	Ro60, Y RNA binding protein	Homo sapiens	118-122
30395870-11	2018	The anti-inflammatory and anti-fibrotic activities of Ro60 ameliorated the severity of DSS-induced colitis in mice by repressing inflammation, fibrosis, angiogenesis, and the production of reactive oxygen species.	dss	87-90	Ro60, Y RNA binding protein	Homo sapiens	54-58
29901822-6	2018	We found that Malt1 deficiency exacerbates DSS-induced colitis in mice, accompanied by higher levels of IL-1beta, and that macrophages and IL-1 signaling contribute to pathology in Malt1-/- mice.	dss	43-46	MALT1 paracaspase	Mus musculus	14-19
29901822-9	2018	Taken together, these data support the hypothesis that Malt1-/- macrophages contribute to increased susceptibility of Malt1-/- mice to DSS-induced colitis, which is dependent on IL-1 signaling.	dss	135-138	MALT1 paracaspase	Mus musculus	55-60
29901822-9	2018	Taken together, these data support the hypothesis that Malt1-/- macrophages contribute to increased susceptibility of Malt1-/- mice to DSS-induced colitis, which is dependent on IL-1 signaling.	dss	135-138	MALT1 paracaspase	Mus musculus	118-123
29901822-9	2018	Taken together, these data support the hypothesis that Malt1-/- macrophages contribute to increased susceptibility of Malt1-/- mice to DSS-induced colitis, which is dependent on IL-1 signaling.	dss	135-138	interleukin 1 complex	Mus musculus	178-182
30127116-9	2018	Results showed that DSS treatment greatly improved the learning and memory deficits of rats with CCH, reduced apoptosis of neurons in the hippocampal CA1, CA3 regions and dentate gyrus, and increased the phosphorylation of PKA, ERK1/2, and CREB in the hippocampus.	dss	20-23	cAMP responsive element binding protein 1	Rattus norvegicus	240-244
30127116-10	2018	These findings suggest that DSS protects against CCH-induced memory impairment and hippocampal damage possibly through activating the PKA/ERK1/2/CREB signaling pathway.	dss	28-31	mitogen activated protein kinase 3	Rattus norvegicus	138-144
30127116-10	2018	These findings suggest that DSS protects against CCH-induced memory impairment and hippocampal damage possibly through activating the PKA/ERK1/2/CREB signaling pathway.	dss	28-31	cAMP responsive element binding protein 1	Rattus norvegicus	145-149
30159037-6	2018	Increased IDO activity and attenuated capacity for antigen presentation and production of inflammatory cytokines, observed in BALB/c DCs, was followed by a significantly lower number of inflammatory T helper 1 (Th1) and Th17 cells and a notably increased number of Tregs in the colons of DSS-treated BALB/c mice.	dss	288-291	indoleamine 2,3-dioxygenase 1	Mus musculus	10-13
30127455-4	2018	We also confirmed the presence of spontaneous intestinal dysbiosis and increased susceptibility to Dextran Sodium Sulfate (DSS)-induced colitis in ERAP1-/- mice, however the transfer of healthy microbiota from wild type mice via cross-fostering experiments did not resolve the skeletal phenotypes of ERAP1-/- mice.	dss	123-126	endoplasmic reticulum aminopeptidase 1	Mus musculus	147-152
28779026-7	2018	RESULTS: Nr2f6-deficient mice were highly susceptible to DSS-induced colitis characterised by enhanced weight loss, increased colonic tissue destruction and immune cell infiltration together with enhanced intestinal permeability and reduced Muc2 expression.	dss	57-60	nuclear receptor subfamily 2, group F, member 6	Mus musculus	9-14
28779026-7	2018	RESULTS: Nr2f6-deficient mice were highly susceptible to DSS-induced colitis characterised by enhanced weight loss, increased colonic tissue destruction and immune cell infiltration together with enhanced intestinal permeability and reduced Muc2 expression.	dss	57-60	mucin 2	Mus musculus	241-245
30415241-2	2018	In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (Tnf-alpha) genes.	dss	195-198	interleukin 1 beta	Mus musculus	353-370
30415241-2	2018	In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (Tnf-alpha) genes.	dss	195-198	interleukin 1 beta	Mus musculus	372-380
30415241-2	2018	In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (Tnf-alpha) genes.	dss	195-198	tumor necrosis factor	Mus musculus	386-413
30415241-2	2018	In this study, we compared the benefits of an angiotensin-converting enzyme (ACE) inhibitor, enalapril, an angiotensin receptor blocker, losartan and their combination in dextran sodium sulfate (DSS)-induced colitis in mice by assessing the histopathological and macroscopic changes in the colon, and by measuring the expression of the pro-inflammatory interleukin 1beta (IL-1beta) and tumor necrosis factor alpha (Tnf-alpha) genes.	dss	195-198	tumor necrosis factor	Mus musculus	415-424
30064196-6	2018	Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR.	dss	26-29	actin alpha 2, smooth muscle, aorta	Mus musculus	165-174
30064196-6	2018	Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR.	dss	26-29	sphingosine kinase 1	Mus musculus	192-197
30064196-6	2018	Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR.	dss	26-29	ras homolog family member A	Mus musculus	199-203
30064196-6	2018	Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR.	dss	26-29	thymoma viral proto-oncogene 1	Mus musculus	211-214
30064196-6	2018	Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR.	dss	26-29	thymoma viral proto-oncogene 1	Mus musculus	218-221
30064196-6	2018	Compared to control mice, DSS-induced chronic colitis mice developed a marked intestinal fibrosis associated with a concomitant overexpression of TGF-beta, p-Smad3, alpha-SMA, collagen I-III, SPHK1, RhoA, PI3K, Akt, p-Akt, p-mTOR.	dss	26-29	mechanistic target of rapamycin kinase	Mus musculus	225-229
29967068-6	2018	hMRP8 Hif-2a KO mice, on the other hand, exhibited a similar degree of DSS-induced colitis to that of WT mice.	dss	71-74	ATP binding cassette subfamily C member 11	Homo sapiens	0-5
29967068-7	2018	Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 Hif-1a KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1alpha in myeloid cells is dispensable for tumorigenesis.	dss	13-16	ATP binding cassette subfamily C member 11	Homo sapiens	106-111
29967068-7	2018	Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 Hif-1a KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1alpha in myeloid cells is dispensable for tumorigenesis.	dss	13-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	112-118
29967068-7	2018	Lastly, when DSS was given together with azoxymethane to induce tumorigenesis in the colon, we found that hMRP8 Hif-1a KO mice exhibited comparable levels of colorectal tumors to those of WT mice, indicating that HIF-1alpha in myeloid cells is dispensable for tumorigenesis.	dss	13-16	hypoxia inducible factor 1, alpha subunit	Mus musculus	213-223
30123054-9	2018	In survival evaluations, high expression of CLCA1 was significantly correlated with worse local recurrence-free survival (LRFS; P=0.0012), metastasis-free survival (MeFS; P =0.0114), and disease-specific survival (DSS; P=0.0041).	dss	214-217	chloride channel accessory 1	Homo sapiens	44-49
30123054-10	2018	Furthermore, high expression of CLCA1 remained an independent prognosticator of shorter LRFS (P=0.029, hazard ratio=2.555), MeFS (P=0.044, hazard ratio=2.125) and DSS (P=0.044, hazard ratio=2.172).	dss	163-166	chloride channel accessory 1	Homo sapiens	32-37
30079348-3	2018	Therefore, we conducted a meta-analysis to determine whether PINX1 expression is associated with overall survival (OS), disease-specific survival (DSS), disease-free survival (DFS), recurrence-free survival (RFS), and clinicopathological characteristics in patients with malignant tumors.	dss	147-150	PIN2 (TERF1) interacting telomerase inhibitor 1	Homo sapiens	61-66
30079348-10	2018	Low PINX1 expression was associated with poor OS (HR: 1.51, 95.0% CI: 1.03-2.20; P = 0.035) and DFS/RFS (HR: 1.78, 95.0% CI: 1.28-2.47; P = 0.001) but not DSS (HR: 0.80, 95.0% CI: 0.38-1.67; P = 0.548).	dss	155-158	PIN2 (TERF1) interacting telomerase inhibitor 1	Homo sapiens	4-9
29995811-4	2018	The subgroup analyses revealed that the expression of WT1 predicted the poor DSS (metaHR = 1.82, 95% CI = 1.42-2.73), and DFS/RFS/PFS (metaHR = 2.51, 95% CI = 1.81-3.48) in patients with ovarian cancer.	dss	77-80	WT1 transcription factor	Homo sapiens	54-57
29608690-8	2018	Results: miR-21-/- mice have reduced susceptibility to DSS-induced colitis compared with WT mice.	dss	55-58	microRNA 21a	Mus musculus	9-15
29608690-9	2018	Co-housing conferred some protection to WT mice, while GF mice colonized with fecal homogenate from miR-21-/- were protected from DSS colitis compared with those colonized with WT homogenate.	dss	130-133	microRNA 21a	Mus musculus	100-106
29921812-7	2018	Moreover, a high dosage of SAA protected against DSS-induced damage to tight junctions (TJ) in the rats&amp;rsquo; colons, by increasing TJ-related gene expression (ZO-1 and occuldin).	dss	49-52	tight junction protein 1	Rattus norvegicus	165-182
29942303-13	2018	In the multivariable regression model, diffuse PD-L1 expression remained significantly unfavorable for DSS (HR 5.0, p &lt; 0.01).	dss	103-106	CD274 molecule	Homo sapiens	47-52
29875204-3	2018	To investigate the immunological consequences of this increased LRRK2 expression, we conducted studies in transgenic mice overexpressing Lrrk2 and showed that these mice exhibited more severe colitis induced by dextran sodium sulfate (DSS) than did littermate control animals.	dss	235-238	leucine-rich repeat kinase 2	Mus musculus	64-69
29875204-8	2018	We then showed that LRRK2 inhibitors decreased Dectin-1-induced TNF-alpha production by mouse DCs and ameliorated DSS-induced colitis, both in control and Lrrk2 transgenic animals.	dss	114-117	leucine-rich repeat kinase 2	Mus musculus	20-25
29867125-7	2018	In our cohort, stromal miR-143 (S-miR-143) and miR-145 (S-miR-145) expression in primary tumor tissue were independent prognosticators of improved disease-specific survival (DSS) in female (S-miR-143, HR: 0.53, p = 0.019) and male patients (S-miR-145, HR: 0.58, p = 0.021), respectively.	dss	174-177	microRNA 143	Homo sapiens	23-30
29867125-7	2018	In our cohort, stromal miR-143 (S-miR-143) and miR-145 (S-miR-145) expression in primary tumor tissue were independent prognosticators of improved disease-specific survival (DSS) in female (S-miR-143, HR: 0.53, p = 0.019) and male patients (S-miR-145, HR: 0.58, p = 0.021), respectively.	dss	174-177	microRNA 145	Homo sapiens	47-54
29867125-7	2018	In our cohort, stromal miR-143 (S-miR-143) and miR-145 (S-miR-145) expression in primary tumor tissue were independent prognosticators of improved disease-specific survival (DSS) in female (S-miR-143, HR: 0.53, p = 0.019) and male patients (S-miR-145, HR: 0.58, p = 0.021), respectively.	dss	174-177	microRNA 145	Homo sapiens	56-65
29625079-12	2018	This study also demonstrated the applicability of DSS as alternative sampling for evaluating DPD activity.	dss	50-53	dihydropyrimidine dehydrogenase	Homo sapiens	93-96
29937187-6	2018	Moreover, high Snail expression had direct impacts on poor disease specific survival (DSS) and disease-free survival (DFS) in breast IDC patients with human epidermal growth factor receptor 2 (HER2)-positive and human epidermal growth factor receptor (EGFR)-positive statuses as well as the HER2 intrinsic subtype.	dss	86-89	snail family transcriptional repressor 1	Homo sapiens	15-20
29937187-7	2018	Additionally, breast IDC patients with a combination of three prognostic factors, including high Snail expression and HER2-positive and EGFR-positive statuses, had much poor DSS and DFS with a statistically significant linear trend.	dss	174-177	erb-b2 receptor tyrosine kinase 2	Homo sapiens	118-122
29721609-6	2018	In the HPV-positive subgroup, patients with moderate, high, or very high MMP-7 expression had significantly worse 5-year disease-specific survival (DSS) (56.6%) than patients with absent, or low MMP-7 expression (77.2%), and MMP-7 expression appeared as a prognostic factor in the multivariate analysis.	dss	148-151	matrix metallopeptidase 7	Homo sapiens	73-78
29721609-8	2018	Our results suggest that among HPV-positive OPSCC patients, high MMP-7 expression is related to worse 5-year DSS and increased rate of distant recurrences.	dss	109-112	matrix metallopeptidase 7	Homo sapiens	65-70
29881294-6	2018	The results indicated that POSTN expression was correlated with the clinicopathologic features, disease-specific survival (DSS), distant metastasis-free survival (DMFS), and local recurrence-free survival (LRFS) of NPC.	dss	123-126	periostin	Homo sapiens	27-32
29881294-9	2018	In univariate analysis, high POSTN expression served as a significant prognostic factor for worse DSS (p=0.0002), DMFS (p=0.0138), and LRFS (p=0.0028).	dss	98-101	periostin	Homo sapiens	29-34
29680209-4	2018	Our data show that AhR activation by FICZ ameliorated colonic inflammation, decreased IL-6 and claudin-2 expression, and maintained intestinal barrier function in a mouse model of dextran sulphate sodium (DSS)-induced colitis.	dss	205-208	aryl-hydrocarbon receptor	Mus musculus	19-22
29572384-7	2018	Compared with mice treated with DSS, mice also treated with exogenous CT-1 showed lower colon damage, DAI, plasma levels of TNFalpha, colon expression of TNF-alpha, INFgamma, IL-17, iNOS and cleaved caspase 3, higher NFkappaB and signal transducer and activator of transcription 3 (STAT3) pathways activation, and absence of bacterial translocation.	dss	32-35	cardiotrophin 1	Mus musculus	70-74
29766049-3	2018	In a previous study, we showed that interleukin 1alpha (IL-1alpha) deficiency in IL-1alpha knockout (KO) mice results in moderate dextran sodium sulfate (DSS)-induced colitis compared to that of wild-type (WT) mice, characterized by reduced inflammation and complete healing, as shown by parameters of weight loss, disease activity index (DAI) score, histology, and cytokine expression.	dss	154-157	interleukin 1 alpha	Mus musculus	36-54
29766049-3	2018	In a previous study, we showed that interleukin 1alpha (IL-1alpha) deficiency in IL-1alpha knockout (KO) mice results in moderate dextran sodium sulfate (DSS)-induced colitis compared to that of wild-type (WT) mice, characterized by reduced inflammation and complete healing, as shown by parameters of weight loss, disease activity index (DAI) score, histology, and cytokine expression.	dss	154-157	interleukin 1 alpha	Mus musculus	56-65
29766049-3	2018	In a previous study, we showed that interleukin 1alpha (IL-1alpha) deficiency in IL-1alpha knockout (KO) mice results in moderate dextran sodium sulfate (DSS)-induced colitis compared to that of wild-type (WT) mice, characterized by reduced inflammation and complete healing, as shown by parameters of weight loss, disease activity index (DAI) score, histology, and cytokine expression.	dss	154-157	interleukin 1 alpha	Mus musculus	81-90
29766049-4	2018	In this study, we tested whether the protective effects of IL-1alpha deficiency on DSS-induced colitis correlate with changes in the gut microbiota and whether manipulation of the microbiota by cohousing can alter patterns of colon inflammation.	dss	83-86	interleukin 1 alpha	Mus musculus	59-68
29766049-7	2018	We demonstrate that host-derived IL-1alpha has a clear influence on gut microbiota composition, as well as on severity of DSS-induced acute colon inflammation.	dss	122-125	interleukin 1 alpha	Mus musculus	33-42
29401402-4	2018	Compared with the model group, the general relative indices results showed L. plantarum ZDY2013 and B. bifidum WBIN03 have a significant effect on DSS-induced UC in mice, by downregulating the pro-inflammatory cytokines (e.g., TNF-alpha) and upregulating antioxidant factors (e.g., SOD1, SOD2, GPX2) at the transcriptional level.	dss	147-150	tumor necrosis factor	Mus musculus	227-236
29401402-4	2018	Compared with the model group, the general relative indices results showed L. plantarum ZDY2013 and B. bifidum WBIN03 have a significant effect on DSS-induced UC in mice, by downregulating the pro-inflammatory cytokines (e.g., TNF-alpha) and upregulating antioxidant factors (e.g., SOD1, SOD2, GPX2) at the transcriptional level.	dss	147-150	superoxide dismutase 1, soluble	Mus musculus	282-286
29401402-4	2018	Compared with the model group, the general relative indices results showed L. plantarum ZDY2013 and B. bifidum WBIN03 have a significant effect on DSS-induced UC in mice, by downregulating the pro-inflammatory cytokines (e.g., TNF-alpha) and upregulating antioxidant factors (e.g., SOD1, SOD2, GPX2) at the transcriptional level.	dss	147-150	superoxide dismutase 2, mitochondrial	Mus musculus	288-292
29401402-4	2018	Compared with the model group, the general relative indices results showed L. plantarum ZDY2013 and B. bifidum WBIN03 have a significant effect on DSS-induced UC in mice, by downregulating the pro-inflammatory cytokines (e.g., TNF-alpha) and upregulating antioxidant factors (e.g., SOD1, SOD2, GPX2) at the transcriptional level.	dss	147-150	glutathione peroxidase 2	Mus musculus	294-298
29396238-5	2018	RESULTS: On univariate analysis, LAG-3+ TILs in the intraepithelial and stromal compartments of primary tumors and in the intraepithelial and extraepithelial compartments of metastatic lymph nodes were associated with improved disease-specific survival (DSS).	dss	254-257	lymphocyte activating 3	Homo sapiens	33-38
29396238-6	2018	On multivariate analysis, stromal LAG-3+ TILs were a significant independent predictor of improved DSS (hazard ratio [HR], 0.59; 95% confidence interval [CI], 0.43-0.82; P = .002).	dss	99-102	lymphocyte activating 3	Homo sapiens	34-39
29555332-9	2018	The DSS, DFS and OS were significantly better in HPV-related than in non HPV-related vulvar SCC patients.	dss	4-7	serpin family B member 3	Homo sapiens	92-95
29121394-10	2018	Echinococcus multilocularis infection markedly reduced the severity of DSS-induced gut inflammation upon down-regulation of Th1/Th17 cytokine expression and attenuation of CD11b+ cell activation.	dss	71-74	integrin subunit alpha M	Homo sapiens	172-177
29796176-2	2018	We aimed to validate the association of tumor AGR2 mRNA expression with disease-specific survival (DSS) and identify differentially expressed signaling pathways between high and low AGR2 expression tumor groups.	dss	99-102	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	46-50
29796176-3	2018	Methods: Primary tumor mRNA expression data from the METABRIC study was used to evaluate AGR2 expression as a prognostic factor for DSS while adjusting for survival-determining confounders using Cox proportional-hazards regression.	dss	132-135	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	89-93
29796176-5	2018	Results: Increased tumor AGR2 mRNA expression was associated with decreased DSS among 1,341 women (per each standard deviation increase of AGR2 expression: HR 1.14, 95% CI: 1.01-1.29, P = 0.03).	dss	76-79	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	25-29
29796176-8	2018	Conclusion: Increased primary tumor AGR2 expression was associated with decreased DSS.	dss	82-85	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	36-40
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	interleukin 1 beta	Mus musculus	46-63
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	interleukin 1 beta	Mus musculus	65-73
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	interleukin 6	Mus musculus	76-89
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	interleukin 6	Mus musculus	91-95
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	tumor necrosis factor	Mus musculus	102-129
29983966-4	2018	Gelatin prevented the DSS-induced increase in interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor-alpha (TNF-alpha) in the colon, rather than in peripheral blood.	dss	22-25	tumor necrosis factor	Mus musculus	131-140
29983966-5	2018	Glycine and Pro-Hyp attenuated the DSS-induced rise in colonic IL-6 and TNF-alpha, as well as peripheral IL-1beta, IL-6, and TNF-alpha.	dss	35-38	interleukin 6	Mus musculus	63-67
29983966-5	2018	Glycine and Pro-Hyp attenuated the DSS-induced rise in colonic IL-6 and TNF-alpha, as well as peripheral IL-1beta, IL-6, and TNF-alpha.	dss	35-38	tumor necrosis factor	Mus musculus	72-81
29550488-7	2018	We demonstrate that deletion of Fbw7 in the mouse intestinal epithelium aggravates DSS-induced colitis, showing inflammatory response and reduced survival rate.	dss	83-86	F-box and WD-40 domain protein 7	Mus musculus	32-36
29471245-8	2018	Taken together, these results indicate that MSCs achieved their beneficial effects in DSS-induced colitis by suppressing inflammatory phenotype of DCs in Gal-3 dependent manner.	dss	86-89	lectin, galactose binding, soluble 3	Mus musculus	154-159
29352742-10	2018	KEY RESULTS: Cambogin attenuated diarrhoea, colon shortening and colon histological injury and IL-6, IFN-gamma and TNF-alpha production in DSS-treated mice.	dss	139-142	interleukin 6	Mus musculus	95-99
29352742-10	2018	KEY RESULTS: Cambogin attenuated diarrhoea, colon shortening and colon histological injury and IL-6, IFN-gamma and TNF-alpha production in DSS-treated mice.	dss	139-142	interferon gamma	Mus musculus	101-110
29352742-10	2018	KEY RESULTS: Cambogin attenuated diarrhoea, colon shortening and colon histological injury and IL-6, IFN-gamma and TNF-alpha production in DSS-treated mice.	dss	139-142	tumor necrosis factor	Mus musculus	115-124
28287113-4	2018	Intestinal epithelial cell (IEC)-specific deletion of TC-PTP was achieved in a mouse model at steady state and in the context of dextran sulphate sodium (DSS)-induced colitis.	dss	154-157	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	54-60
28287113-6	2018	However, upon DSS treatment, IEC-specific TC-PTP KO mice displayed a more severe colitis phenotype with a corresponding increase in the immune response and inflammatory cytokine profile.	dss	14-17	protein tyrosine phosphatase, non-receptor type 2	Mus musculus	42-48
29475099-10	2018	In conclusion, CX-10 treatment attenuated DSS-induced UC in mice through inhibiting the activation of NF-kappaB and MAPK pathways and reducing TNF-alpha and IL-6 levels, suggesting that CX-10 is a potential therapeutic drug for UC.	dss	42-45	mitogen-activated protein kinase 1	Mus musculus	116-120
29475099-10	2018	In conclusion, CX-10 treatment attenuated DSS-induced UC in mice through inhibiting the activation of NF-kappaB and MAPK pathways and reducing TNF-alpha and IL-6 levels, suggesting that CX-10 is a potential therapeutic drug for UC.	dss	42-45	interleukin 6	Mus musculus	157-161
29517632-8	2018	In multivariate analysis, only TN-C expression was a significant prognostic factor for DSS.	dss	87-90	tenascin C	Homo sapiens	31-35
29573252-11	2018	In line with this data, the severity of DSS-induced mouse colitis was greatly ameliorated by the treatment of IGFBP-3 expressing adenoviral particles characterized with less weight loss and preserved colon length compared with the mice treated with DSS alone.	dss	40-43	insulin-like growth factor binding protein 3	Mus musculus	110-117
29573252-12	2018	The histopathology of the colon showed the reducing signs of colitis in Ad/IGFBP-3 treated DSS-mice group.	dss	91-94	insulin-like growth factor binding protein 3	Mus musculus	75-82
29317503-9	2018	Systemic delivery of the DAPK1 inhibitor DAPK6 increased bacterial translocation in DSS- or DNP-treated mice.	dss	84-87	death associated protein kinase 1	Mus musculus	25-30
29351397-7	2018	Specifically, a deficit in CD103+ DCs observed during acute DSS in the lamina propria was reversed and further enhanced during recovery.	dss	60-63	integrin alpha E, epithelial-associated	Mus musculus	27-32
29205321-5	2018	Three-year conditional DSS (CDS3 ) of patients who had already survived for x years was estimated as CDS3 = DSS(x + 3)/DSS(x).	dss	23-26	motile sperm domain containing 3	Homo sapiens	28-32
29205321-5	2018	Three-year conditional DSS (CDS3 ) of patients who had already survived for x years was estimated as CDS3 = DSS(x + 3)/DSS(x).	dss	23-26	motile sperm domain containing 3	Homo sapiens	101-105
29205321-5	2018	Three-year conditional DSS (CDS3 ) of patients who had already survived for x years was estimated as CDS3 = DSS(x + 3)/DSS(x).	dss	108-111	motile sperm domain containing 3	Homo sapiens	28-32
29205321-5	2018	Three-year conditional DSS (CDS3 ) of patients who had already survived for x years was estimated as CDS3 = DSS(x + 3)/DSS(x).	dss	108-111	motile sperm domain containing 3	Homo sapiens	101-105
29205321-5	2018	Three-year conditional DSS (CDS3 ) of patients who had already survived for x years was estimated as CDS3 = DSS(x + 3)/DSS(x).	dss	108-111	motile sperm domain containing 3	Homo sapiens	28-32
29205321-5	2018	Three-year conditional DSS (CDS3 ) of patients who had already survived for x years was estimated as CDS3 = DSS(x + 3)/DSS(x).	dss	108-111	motile sperm domain containing 3	Homo sapiens	101-105
29386247-8	2018	Multivariate analysis confirmed that patients with AR/ER&gt;=2 had worse disease-free interval (DFI) and disease-specific survival (DSS) (hazard ratios (HR) = 4.96 for DFI and HR = 8.69 for DSS, both P &lt;= 0.004).	dss	132-135	androgen receptor	Homo sapiens	51-53
29386247-8	2018	Multivariate analysis confirmed that patients with AR/ER&gt;=2 had worse disease-free interval (DFI) and disease-specific survival (DSS) (hazard ratios (HR) = 4.96 for DFI and HR = 8.69 for DSS, both P &lt;= 0.004).	dss	190-193	androgen receptor	Homo sapiens	51-53
29331766-7	2018	Rof also suppressed the inflammatory response induced in DSS colitis group by decreasing colon concentration of TNF-alpha, NO and MPO activity and down- regulation of iNOS gene expression.	dss	57-60	tumor necrosis factor	Rattus norvegicus	112-121
29331766-7	2018	Rof also suppressed the inflammatory response induced in DSS colitis group by decreasing colon concentration of TNF-alpha, NO and MPO activity and down- regulation of iNOS gene expression.	dss	57-60	myeloperoxidase	Rattus norvegicus	130-133
29331766-7	2018	Rof also suppressed the inflammatory response induced in DSS colitis group by decreasing colon concentration of TNF-alpha, NO and MPO activity and down- regulation of iNOS gene expression.	dss	57-60	nitric oxide synthase 2	Rattus norvegicus	167-171
29286110-2	2018	Our previous study demonstrated that DRA deficiency is associated with severely reduced colonic HCO3- secretion, a loss of colonic fluid absorption, a lack of a firmly adherent mucus layer and a severely reduced colonic mucosal resistance to dextran sodium sulfate (DSS) damage.	dss	266-269	solute carrier family 26 member 3	Homo sapiens	37-40
29286110-6	2018	The present study identified that the expression level of DRA was reduced in active UC patients and DSS-induced colitis mice with high expression levels of TNF-alpha identified in the peripheral blood serum.	dss	100-103	solute carrier family 26 member 3	Homo sapiens	58-61
29286110-6	2018	The present study identified that the expression level of DRA was reduced in active UC patients and DSS-induced colitis mice with high expression levels of TNF-alpha identified in the peripheral blood serum.	dss	100-103	tumor necrosis factor	Mus musculus	156-165
28983662-10	2018	The estimated post-RFA DSS of patients with wild-type and mutant SMAD4 was 22 and 12 months, respectively (log-rank p &lt; 0.05).	dss	23-26	SMAD family member 4	Homo sapiens	65-70
29355546-7	2018	Magnolol also enhanced the expression of ZO-1 and occludin in DSS-induced mice colonic tissues.	dss	62-65	tight junction protein 1	Mus musculus	41-45
29355546-7	2018	Magnolol also enhanced the expression of ZO-1 and occludin in DSS-induced mice colonic tissues.	dss	62-65	occludin	Mus musculus	50-58
29401168-10	2018	CONCLUSIONS: There were excellent outcomes for most GEP-NET patients, with a 20-year DSS of greater than 75% across all sites and stages.	dss	85-88	granulin precursor	Homo sapiens	52-55
29511373-9	2018	SERPINB5 overexpression was not only negatively associated with disease-specific survival (DSS), local recurrence-free survival (LRFS) and metastasis-free survival (MeFS) rates in univariate analyses but also was an independent prognostic factor for DSS and MeFS in rectal cancer patients (all P &lt;= 0.043).	dss	91-94	serpin family B member 5	Homo sapiens	0-8
29511373-9	2018	SERPINB5 overexpression was not only negatively associated with disease-specific survival (DSS), local recurrence-free survival (LRFS) and metastasis-free survival (MeFS) rates in univariate analyses but also was an independent prognostic factor for DSS and MeFS in rectal cancer patients (all P &lt;= 0.043).	dss	250-253	serpin family B member 5	Homo sapiens	0-8
29051186-3	2018	Here, the role of Hsp70-mediated intestinal epithelial protection and immune regulation in experimental colitis was examined by using a villin promoter-driven Hsp70 transgene in the 2,4,6-trinitrobenzene sulfonic acid (TNBS) and dextran sodium sulfate (DSS) models and in IL-10/Hsp70 double knockout (IL10-/-/Hsp70-/-) mice.	dss	253-256	heat shock protein 1B	Mus musculus	18-23
29051186-5	2018	We found that the epithelial-specific expression of Hsp70 transgene attenuated DSS-induced colitis in Hsp70-/- mice by protecting tight junctions (TJ) and their interaction with the TJ-associated protein ZO-1.	dss	79-82	heat shock protein 1B	Mus musculus	52-57
29051186-5	2018	We found that the epithelial-specific expression of Hsp70 transgene attenuated DSS-induced colitis in Hsp70-/- mice by protecting tight junctions (TJ) and their interaction with the TJ-associated protein ZO-1.	dss	79-82	heat shock protein 1B	Mus musculus	102-107
29207040-0	2018	Aryl hydrocarbon receptor inhibits inflammation in DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	51-54	aryl-hydrocarbon receptor	Mus musculus	0-25
29207040-0	2018	Aryl hydrocarbon receptor inhibits inflammation in DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	51-54	MAP kinase-activated protein kinase 2	Mus musculus	79-82
29207040-0	2018	Aryl hydrocarbon receptor inhibits inflammation in DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	51-54	MAP kinase-activated protein kinase 2	Mus musculus	85-88
29207040-0	2018	Aryl hydrocarbon receptor inhibits inflammation in DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	51-54	zinc finger protein 36	Mus musculus	89-92
29207040-10	2018	In addition, mice in the AhR-knockout + DSS group exhibited elevated inflammatory cytokine production and developed more severe colitis.	dss	40-43	aryl-hydrocarbon receptor	Mus musculus	25-28
29207040-13	2018	These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	144-147	aryl-hydrocarbon receptor	Mus musculus	115-118
29207040-13	2018	These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	144-147	MAP kinase-activated protein kinase 2	Mus musculus	172-175
29207040-13	2018	These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	144-147	MAP kinase-activated protein kinase 2	Mus musculus	178-181
29207040-13	2018	These results suggested that AhR deficiency resulted in increased susceptibility to colitis, whereas activation of AhR by FICZ could ameliorate DSS-induced colitis via the MK2/p-MK2/TTP pathway.	dss	144-147	zinc finger protein 36	Mus musculus	182-185
29076924-2	2018	The aim of this study was to investigate whether that association is manifested at the DCP1A expression and whether an altered DCP1A expression can predict disease-specific survival (DSS) of MM patients.	dss	183-186	decapping mRNA 1A	Homo sapiens	127-132
29076924-8	2018	Higher DCP1A expression was significantly correlated with shorter DSS time in patients with MM (P&lt;0.05).	dss	66-69	decapping mRNA 1A	Homo sapiens	7-12
29076924-9	2018	The multivariate Cox regression analysis revealed that DCP1A expression was an independent prognostic factor for DSS (hazard ratio=1.648, P=0.021).	dss	113-116	decapping mRNA 1A	Homo sapiens	55-60
30298837-2	2018	The present study aimed to elucidate the function and expression of TRPV4 in colonic vascular endothelial cells during dextran sulphate sodium (DSS)-induced colitis.	dss	144-147	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	68-73
30846173-6	2019	Simultaneous PD-L1 and PD-L2 overexpression was detected in 13.3% of cases, and was correlated with reduced DSS (P = 0.0113).	dss	108-111	CD274 molecule	Homo sapiens	13-18
30846173-6	2019	Simultaneous PD-L1 and PD-L2 overexpression was detected in 13.3% of cases, and was correlated with reduced DSS (P = 0.0113).	dss	108-111	programmed cell death 1 ligand 2	Homo sapiens	23-28
29949801-8	2018	High YKL-40 levels were associated with shorter OS (p = 0.037) and DSS (p = 0.017) in patients who received DOC in the first-line setting.	dss	67-70	chitinase 3 like 1	Homo sapiens	5-11
29949801-9	2018	In multivariable analysis, ECOG performance status (p = 0.009), presence of any metastases (p = 0.016) and high PSA levels (p = 0.005) remained independent predictors for DSS.	dss	171-174	kallikrein related peptidase 3	Homo sapiens	112-115
29949801-11	2018	In accordance, high pre-treatment YKL-40 serum levels were associated with shorter OS and DSS in patients who received DOC as first-line therapy.	dss	90-93	chitinase 3 like 1	Homo sapiens	34-40
29282038-10	2017	The TP53 mutation group displayed significantly worse DSS and overall survival rates than the wild-type group (P = 0.01 and P = 0.007, respectively).	dss	54-57	tumor protein p53	Homo sapiens	4-8
29317577-13	2017	:  Conclusion: Anti-CXCL1 Ab relieves the progression of DSS-induced acute ulcerative colitis by suppressing proinflammatory expression and neutrophil infiltration.	dss	57-60	chemokine (C-X-C motif) ligand 1	Mus musculus	20-25
29492198-4	2018	Results: High expression of UBASH3B is negatively correlated with distant metastasis free survival (DMFS, P = 0.01, P = 0.045, P = 0.04 in 2 independent datasets and a merged dataset, respectively), disease specific survival (DSS, P = 0.028) and disease free survival (DFS, P = 0.0052, P = 0.011, P = 0.016 in 3 independent datasets, respectively) in ER+ breast cancer patients.	dss	226-229	ubiquitin associated and SH3 domain containing B	Homo sapiens	28-35
28937245-8	2017	BDNF level was increased in DSS-induced colitis in longitudinal SMCs.	dss	28-31	brain-derived neurotrophic factor	Rattus norvegicus	0-4
28937245-9	2017	NGF, NT-3 and NT-4 levels were downregulated in longitudinal SMCs of DSS-induced colitis rats" colon.	dss	69-72	nerve growth factor	Rattus norvegicus	0-3
28937245-9	2017	NGF, NT-3 and NT-4 levels were downregulated in longitudinal SMCs of DSS-induced colitis rats" colon.	dss	69-72	neurotrophin 3	Rattus norvegicus	5-18
29272487-4	2017	We aimed to discover the organization of Duox2, Duoxa2, and Lpo expression in colonic crypts of Lieberkuhn (intestinal glands) of mice and how distributions respond to dextran sodium sulfate (DSS)-induced colitis and subsequent mucosal regeneration.	dss	192-195	lactoperoxidase	Mus musculus	60-63
29272487-8	2017	Duox2 and Duoxa2 mRNA were increased during the induction and resolution of DSS colitis, while Lpo expression did not increase during the acute phase.	dss	76-79	dual oxidase 2	Homo sapiens	0-5
29272487-8	2017	Duox2 and Duoxa2 mRNA were increased during the induction and resolution of DSS colitis, while Lpo expression did not increase during the acute phase.	dss	76-79	dual oxidase maturation factor 2	Homo sapiens	10-16
29312336-7	2017	CD9-/- mice showed less severe colitis than wild-type counterparts upon exposure to DSS (2% solution) and enhanced survival in response to a lethal DSS dose (4%).	dss	84-87	CD9 antigen	Mus musculus	0-3
29312336-7	2017	CD9-/- mice showed less severe colitis than wild-type counterparts upon exposure to DSS (2% solution) and enhanced survival in response to a lethal DSS dose (4%).	dss	148-151	CD9 antigen	Mus musculus	0-3
29107070-4	2017	Interestingly, upon DSS treatment, we noticed an overexpression of Runx1/2/3 transcription factors in both wild-type and uPA-deficient mice.	dss	20-23	runt related transcription factor 1	Mus musculus	67-76
29107070-4	2017	Interestingly, upon DSS treatment, we noticed an overexpression of Runx1/2/3 transcription factors in both wild-type and uPA-deficient mice.	dss	20-23	plasminogen activator, urokinase	Mus musculus	121-124
29107070-5	2017	Moreover, Runx1 and Runx2 expression levels exhibited an even higher increase in DSS-treated/uPA-deficient mice as compared to DSS-treated/wild-type animals.	dss	81-84	runt related transcription factor 1	Mus musculus	10-15
29107070-5	2017	Moreover, Runx1 and Runx2 expression levels exhibited an even higher increase in DSS-treated/uPA-deficient mice as compared to DSS-treated/wild-type animals.	dss	81-84	runt related transcription factor 2	Mus musculus	20-25
29107070-5	2017	Moreover, Runx1 and Runx2 expression levels exhibited an even higher increase in DSS-treated/uPA-deficient mice as compared to DSS-treated/wild-type animals.	dss	81-84	plasminogen activator, urokinase	Mus musculus	93-96
29107070-5	2017	Moreover, Runx1 and Runx2 expression levels exhibited an even higher increase in DSS-treated/uPA-deficient mice as compared to DSS-treated/wild-type animals.	dss	127-130	runt related transcription factor 1	Mus musculus	10-15
29107070-5	2017	Moreover, Runx1 and Runx2 expression levels exhibited an even higher increase in DSS-treated/uPA-deficient mice as compared to DSS-treated/wild-type animals.	dss	127-130	runt related transcription factor 2	Mus musculus	20-25
29107070-6	2017	In all experimental conditions, in situ investigation of Runx-expressing cell types, revealed detection of all three Runx in the immune cells, yet in the DSS-treated/uPA-deficient mice Runx1 and Runx2 were also identified in the preneoplastic epithelium of advanced high-grade dysplasia and carcinoma in-situ colonic lesions.	dss	154-157	plasminogen activator, urokinase	Mus musculus	166-169
29107070-6	2017	In all experimental conditions, in situ investigation of Runx-expressing cell types, revealed detection of all three Runx in the immune cells, yet in the DSS-treated/uPA-deficient mice Runx1 and Runx2 were also identified in the preneoplastic epithelium of advanced high-grade dysplasia and carcinoma in-situ colonic lesions.	dss	154-157	runt related transcription factor 1	Mus musculus	185-190
29107070-6	2017	In all experimental conditions, in situ investigation of Runx-expressing cell types, revealed detection of all three Runx in the immune cells, yet in the DSS-treated/uPA-deficient mice Runx1 and Runx2 were also identified in the preneoplastic epithelium of advanced high-grade dysplasia and carcinoma in-situ colonic lesions.	dss	154-157	runt related transcription factor 2	Mus musculus	195-200
28641187-3	2017	The main objective of this study is to present the developed framework of a multi-criteria Decision Support System (DSS) that integrates within a dynamic platform the main groundwater engineering parameters associated with MAR applications together with the general geographical features which determine the effectiveness of such a project.	dss	116-119	interferon regulatory factor 1	Homo sapiens	223-226
28641187-4	2017	The proposed system will provide an advanced coupled DSS-GIS tool capable of handling local MAR-related issues -such as hydrogeology, topography, soil, climate etc., and spatially distributed variables -such as societal, economic, administrative, legislative etc., with special reference to Soil-Aquifer-Treatment technologies.	dss	53-56	interferon regulatory factor 1	Homo sapiens	92-95
29242509-7	2017	Based on Cox regression analysis, patients with high levels of SHP2 and low levels of nuclear STAT3 had longer disease-specific survival (DSS) (HR, 0.362; 95% CI, 0.165-0.794) and disease-free survival (DFS) (HR, 0.447; 95% CI, 0.227-0.877).	dss	138-141	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	63-67
29242509-7	2017	Based on Cox regression analysis, patients with high levels of SHP2 and low levels of nuclear STAT3 had longer disease-specific survival (DSS) (HR, 0.362; 95% CI, 0.165-0.794) and disease-free survival (DFS) (HR, 0.447; 95% CI, 0.227-0.877).	dss	138-141	signal transducer and activator of transcription 3	Homo sapiens	94-99
28929336-4	2017	Melatonin stifled the expression of colonic IL-17 in mice with DSS-induced colitis.	dss	63-66	interleukin 17A	Mus musculus	44-49
29153098-6	2017	Using cut point analysis and comparison of Kaplan-Meier survival curves by log rank tests, high amplification levels of MDM2 (&gt;38 copies) and CDK4 (&gt;30 copies) correlated with decreased disease free survival (DFS) (P = .0168 and 0.0169 respectively) and disease specific survival (DSS) (P = .0082 and 0.0140 respectively).	dss	287-290	MDM2 proto-oncogene	Homo sapiens	120-124
29153098-6	2017	Using cut point analysis and comparison of Kaplan-Meier survival curves by log rank tests, high amplification levels of MDM2 (&gt;38 copies) and CDK4 (&gt;30 copies) correlated with decreased disease free survival (DFS) (P = .0168 and 0.0169 respectively) and disease specific survival (DSS) (P = .0082 and 0.0140 respectively).	dss	287-290	cyclin dependent kinase 4	Homo sapiens	145-149
28624320-13	2017	DSS was greater in patients without VHL methylation (P = .012), with &gt; 10% HIF1-alpha expression (P = .037), or with ERK5 protein underexpression.	dss	0-3	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
28624320-13	2017	DSS was greater in patients without VHL methylation (P = .012), with &gt; 10% HIF1-alpha expression (P = .037), or with ERK5 protein underexpression.	dss	0-3	mitogen-activated protein kinase 7	Homo sapiens	120-124
28166396-6	2017	MAIN OUTCOME MEASURE: Overall survival, disease-specific survival (DSS) and disease-free survival (DFS) rates RESULTS: Positive ELMO3 expression was found in 23% of the patients and was correlated with poor DSS and DFS (P&lt;.05).	dss	207-210	engulfment and cell motility 3	Homo sapiens	128-133
28929221-12	2017	In conclusion, our results showed a high level of overall DSS (96%) for patients affected by T1b glottic SCC.	dss	58-61	serpin family B member 3	Homo sapiens	105-108
30334016-8	2017	Immunohistochemical EPO expression affected overall survival (OS) and disease-specific survival (DSS) rates.	dss	97-100	erythropoietin	Homo sapiens	20-23
30334016-9	2017	The DSS rates of the patients whose tissue was positive and negative for EPO expression were 85.3% and 76.1%, respectively (p = 0.044).	dss	4-7	erythropoietin	Homo sapiens	73-76
30334016-10	2017	In a multivariate analysis, the absence of EPO expression proved to be a bad prognostic factor and negatively affected the OS (p &lt; 0.001) and DSS (p &lt; 0.001) rates.	dss	145-148	erythropoietin	Homo sapiens	43-46
29127353-9	2017	Importantly, Kaplan-Meier survival analysis showed that the disease-specific survival (DSS) and recurrence-free survival (RFS) were lower in CL with high PKM2 expression than in NCL with high PKM2 expression (P = 0.003 and P = 0.003, respectively).	dss	87-90	pyruvate kinase M1/2	Homo sapiens	154-158
29185927-8	2017	Therefore, increased Hsp25 levels and modification of colonic ECM contribute to the observed psyllium-mediated protection against DSS-induced colitis.	dss	130-133	heat shock protein 1	Mus musculus	21-26
28707078-5	2017	CTLA-4 expression in neither tumor epithelial cells (T-CTLA-4) nor stromal cells (S-CTLA-4) of primary tumors was significantly associated with disease-specific survival (DSS) in all patients.	dss	171-174	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	0-6
28707078-6	2017	However, high S-CTLA-4 expression independently predicted significantly improved DSS in the squamous cell carcinoma subgroup (HR 0.62, 95% CI 0.41-0.93, P = 0.021).	dss	81-84	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	16-22
28782304-7	2017	Surgically treated p16-negative patients had improved 5-year disease-specific survival (DSS) and overall survival (OS) compared with nonsurgical patients.	dss	88-91	cyclin dependent kinase inhibitor 2A	Homo sapiens	19-22
28923419-8	2017	In survival analyses, cases with combined high CD163 counts and BVI showed a significantly reduced recurrence-free survival (RFS) and disease-specific survival (DSS) (P &lt; .001 for both) compared with all other cases.	dss	161-164	CD163 molecule	Homo sapiens	47-52
29017096-4	2017	METHODS: 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) or 3,3"-diindolylmethane (DIM) were used to activate aryl hydrocarbon receptor (Ahr) in azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced CAC in mice.	dss	183-186	aryl-hydrocarbon receptor	Mus musculus	105-130
28560787-9	2017	An antibody that neutralized IL-17A blocked the ability of DSS-induced colitis and Crohn"s disease supernatants to induce axon extension.	dss	59-62	interleukin 17A	Mus musculus	29-35
29098033-2	2017	Carbonic anhydrase IX (CAIX) and Ki-67 have been associated with reduced disease-specific survival (DSS) in patients with OSCC.	dss	100-103	carbonic anhydrase 9	Homo sapiens	0-21
29098033-2	2017	Carbonic anhydrase IX (CAIX) and Ki-67 have been associated with reduced disease-specific survival (DSS) in patients with OSCC.	dss	100-103	carbonic anhydrase 9	Homo sapiens	23-27
29098033-15	2017	However, the association between DSS and tCAIX and sCAIX supports a role for CAIX in OSCC clinical outcomes.	dss	33-36	carbonic anhydrase 9	Homo sapiens	42-46
29113196-0	2017	Inhibition of DMH-DSS-induced colorectal cancer by liposomal bovine lactoferrin in rats.	dss	18-21	lactotransferrin	Bos taurus	68-79
29074847-6	2017	In pN1 patients, those with LODDS 4 had the worst 5-year DSS (41.2%) and OS (31.6%) than patients with pN1 and LODDS 2-3.	dss	57-60	serpin family E member 2	Homo sapiens	3-6
29074847-7	2017	In pN2 patients, those with LODDS4 had the worst 5-year DSS (34.5%) and OS (27.4%) than patients with pN2 and LODDS 2-3.	dss	56-59	amyloid beta precursor protein	Homo sapiens	3-6
29066772-7	2017	Upon environmental epithelial injury using dextran sodium sulfate (DSS), Tfeb DeltaIEC mice exhibited exaggerated colitis.	dss	67-70	transcription factor EB	Mus musculus	73-77
29057966-1	2017	Mice deficient in the megakaryoblastic leukaemia 1 (Mkl1) gene experience less severe dextran sulphate sodium (DSS)-induced colitis, implying that Mkl1 plays a pathological role in inflammatory bowel disease (IBD).	dss	111-114	myocardin related transcription factor A	Mus musculus	22-50
29057966-1	2017	Mice deficient in the megakaryoblastic leukaemia 1 (Mkl1) gene experience less severe dextran sulphate sodium (DSS)-induced colitis, implying that Mkl1 plays a pathological role in inflammatory bowel disease (IBD).	dss	111-114	myocardin related transcription factor A	Mus musculus	52-56
29057966-1	2017	Mice deficient in the megakaryoblastic leukaemia 1 (Mkl1) gene experience less severe dextran sulphate sodium (DSS)-induced colitis, implying that Mkl1 plays a pathological role in inflammatory bowel disease (IBD).	dss	111-114	myocardin related transcription factor A	Mus musculus	147-151
29057966-3	2017	The expression of Mkl1 is higher in the colonic lamina propria macrophages (LPMac) of DSS-treated mice than in those of control mice.	dss	86-89	myocardin related transcription factor A	Mus musculus	18-22
29057966-7	2017	In addition, MKL1-Tg mice had higher susceptibility to DSS-induced colitis than their littermate controls.	dss	55-58	myocardin related transcription factor A	Mus musculus	13-17
29026145-7	2017	Correspondingly, DSS-exposed mice treated with cibinetide or EPO displayed preserved tissue integrity due to reduced infiltration of myeloid cells and diminished production of pro-inflammatory disease mediators including cytokines, chemokines and nitric oxide synthase-2.	dss	17-20	erythropoietin	Mus musculus	61-64
28535907-3	2017	In this study, we determined the role of A-kinase anchor protein 13 (AKAP13) in mice with dextran sulphate sodium (DSS)-induced colitis upon mucosal injury and restitution, and investigated whether inhibition of Rho-associated coiled-coil containing protein kinase (ROCK), downstream effector of AKAP13, affects these mucosal responses.	dss	115-118	A kinase (PRKA) anchor protein 13	Mus musculus	69-75
28535907-6	2017	In immunohistochemistry, AKAP13 was highly expressed in the mucosal epithelium prior to DSS-induced mucosal injury, and also expressed in ulcer-covering non-proliferative epithelium, which corresponded to restituted epithelial cells.	dss	88-91	A kinase (PRKA) anchor protein 13	Mus musculus	25-31
28535907-9	2017	These results suggested that AKAP13 and ROCK are involved in mucosal response at early injury and restitution during healing in DSS-induced colitis in mice.	dss	128-131	A kinase (PRKA) anchor protein 13	Mus musculus	29-35
28750357-5	2017	Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1beta release in colons treated with DSS.	dss	177-180	NLR family, pyrin domain containing 3	Mus musculus	65-70
28750357-5	2017	Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1beta release in colons treated with DSS.	dss	177-180	caspase 1	Mus musculus	99-108
28750357-5	2017	Further study revealed that WEL treatment dramatically inhibited NLRP3 inflammasome activation and caspase-1 phosphorylation to decrease IL-1beta release in colons treated with DSS.	dss	177-180	interleukin 1 beta	Mus musculus	137-145
27374794-7	2017	As expected, the disease activity index (DAI) value was significantly increased in the BRD7-/- mice after DSS treatment for 1-5 days, which was demonstrated by the presence of a significantly shorter colon, splenomegaly and tissue damage.	dss	106-109	bromodomain containing 7	Mus musculus	87-91
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	interleukin 6	Mus musculus	38-42
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	tumor necrosis factor	Mus musculus	44-53
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	55-58
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	chemokine (C-X-C motif) ligand 1	Mus musculus	60-66
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	nitric oxide synthase 2, inducible	Mus musculus	71-75
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	114-117
27374794-8	2017	Moreover, higher expression levels of IL-6, TNF-alpha, p65, CXCL-1 and iNOS, and an increased level of NF-kappaB (p65) nuclear translocation were also found in the DSS-treated BRD7-/- mice.	dss	164-167	bromodomain containing 7	Mus musculus	176-180
28691255-4	2017	RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03).	dss	73-76	serpin family B member 3	Homo sapiens	148-151
28691255-4	2017	RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) rates after surgery alone were higher in HPV-associated oropharyngeal SCC (OS 80% vs 62%; P = .01; DSS 92% vs 76%; P = .03).	dss	177-180	serpin family B member 3	Homo sapiens	148-151
28483799-8	2017	CONCLUSIONS: Duplication of the DSS region containing the MAGEB and NR0B1 genes has been implicated in testis repression and sex reversal.	dss	32-35	nuclear receptor subfamily 0 group B member 1	Homo sapiens	68-73
28608623-3	2017	METHODS AND RESULTS: Administration of dextran sodium sulfate (DSS) increased myeloperoxidase activity and CXC motif chemokine ligand2 (an IL-8 homolog) expression in the small intestines of mice, while supplemental GG reduced these increases.	dss	63-66	myeloperoxidase	Mus musculus	78-93
28608623-3	2017	METHODS AND RESULTS: Administration of dextran sodium sulfate (DSS) increased myeloperoxidase activity and CXC motif chemokine ligand2 (an IL-8 homolog) expression in the small intestines of mice, while supplemental GG reduced these increases.	dss	63-66	chemokine (C-X-C motif) ligand 15	Mus musculus	139-143
28608623-8	2017	Finally, supplemental GG increased SOCS-1 expression in the small intestines of both DSS-administered and normal mice.	dss	85-88	suppressor of cytokine signaling 1	Mus musculus	35-41
28987717-10	2017	It can be concluded that Nrf2 activation by higher RA amount contained in En is, at least in part, responsible for the improved protection associated with En intake against DSS-induced colitis.	dss	173-176	nuclear factor, erythroid derived 2, like 2	Mus musculus	25-29
28554049-5	2017	We observed that DSS-induced colitis in IDH2-/- mice was more severe than that in wild-type IDH2+/+ mice.	dss	17-20	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	40-44
28554049-7	2017	In addition, DSS-induced colitis is ameliorated by an antioxidant N-acetylcysteine (NAC) through attenuation of oxidative stress, resulting from deficiency of the IDH2 gene.	dss	13-16	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	163-167
28554049-8	2017	In conclusion, deficiency of IDH2 leads to increased mitochondrial ROS levels, which inhibits HDAC activity, and the activation of NF-kappaB via acetylation is enhanced by attenuated HDAC activity, which causes PUMA-mediated apoptosis of IEC in DSS-induced colitis.	dss	245-248	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	29-33
28926599-5	2017	Collagen-induced arthritis (CIA) was induced at day 0 in DBA1 mice exposed or not to Dextran Sodium Sulfate (DSS) to induce colitis between day 14 and day 21.	dss	109-112	nuclear receptor coactivator 5	Mus musculus	0-32
28955241-5	2017	Four histamine receptors are currently known of which the histamine H4-receptor (H4R) has been shown to possess a pro-inflammatory function in several experimental models of inflammatory diseases, including dextran sodium sulfate (DSS)-induced colitis in mice.	dss	231-234	histamine receptor H4	Mus musculus	58-79
28887507-8	2017	CA inhibited DSS-induced NLRP3 inflammasome activation by reducing caspase 1 activity.	dss	13-16	NLR family pyrin domain containing 3	Homo sapiens	25-30
28887507-8	2017	CA inhibited DSS-induced NLRP3 inflammasome activation by reducing caspase 1 activity.	dss	13-16	caspase 1	Homo sapiens	67-76
29276753-9	2018	Animals with epithelium-specific deletion of Ihh or lacking the Hedgehog receptor Smoothened from Hedgehog target cells were more sensitive to DSS colitis.	dss	143-146	Indian hedgehog signaling molecule	Homo sapiens	45-48
28572005-1	2017	We previously reported that reelin, an extracellular matrix protein first known for its key role in neuronal migration, reduces the susceptibility to dextran sulphate sodium (DSS)-colitis.	dss	175-178	reelin	Mus musculus	28-34
28522594-3	2017	We investigated the effect of SMS2 deficiency on dextran sodium sulfate (DSS)-induced murine colitis and found inhibition of DSS-induced inflammation in SMS2-deficient (SMS2-/-) mice.	dss	73-76	sphingomyelin synthase 2	Mus musculus	30-34
28522594-4	2017	DSS treatment induced a significant increase in ceramide levels, with a decrease of SM levels in SMS2-/- colon tissue, and demonstrated attenuation of the elevation of both inflammation-related gene expression and proinflammatory cytokines and chemokines, leukocyte infiltration, and MAPK and signal transducer and activator of transcription 3 activation.	dss	0-3	sphingomyelin synthase 2	Mus musculus	97-101
28522594-4	2017	DSS treatment induced a significant increase in ceramide levels, with a decrease of SM levels in SMS2-/- colon tissue, and demonstrated attenuation of the elevation of both inflammation-related gene expression and proinflammatory cytokines and chemokines, leukocyte infiltration, and MAPK and signal transducer and activator of transcription 3 activation.	dss	0-3	signal transducer and activator of transcription 3	Mus musculus	293-343
28605639-0	2017	Ginsenoside Rg1 attenuates the inflammatory response in DSS-induced mice colitis.	dss	56-59	protein phosphatase 1, regulatory subunit 3A	Mus musculus	12-15
28472257-8	2017	When compared with wild type, DSS-induced colitis was exacerbated in Entpd2, and to a lesser extent, Entpd3 null mice as measured by disease activity score and histology, and marked anaemia was seen in both.	dss	30-33	ectonucleoside triphosphate diphosphohydrolase 2	Mus musculus	69-75
28472257-8	2017	When compared with wild type, DSS-induced colitis was exacerbated in Entpd2, and to a lesser extent, Entpd3 null mice as measured by disease activity score and histology, and marked anaemia was seen in both.	dss	30-33	ectonucleoside triphosphate diphosphohydrolase 3	Mus musculus	101-107
28648739-4	2017	GPR35 function was examined in a wound healing model, using young adult mouse colon epithelium (YAMC) cells, and in a dextran sulphate sodium (DSS)-induced mouse model of colitis.	dss	143-146	G protein-coupled receptor 35	Mus musculus	0-5
28648739-8	2017	Furthermore, the severity of DSS-induced colitis was significantly reduced by daily injections of pamoic acid via upregulation of fibronectin and integrin alpha5 in the colonic epithelium.	dss	29-32	fibronectin 1	Mus musculus	130-141
28648739-8	2017	Furthermore, the severity of DSS-induced colitis was significantly reduced by daily injections of pamoic acid via upregulation of fibronectin and integrin alpha5 in the colonic epithelium.	dss	29-32	integrin alpha 5 (fibronectin receptor alpha)	Mus musculus	146-161
28928864-8	2017	Furthermore, DUOX2 high expression was significantly associated with inferior DSS, LRFS and MeFS in univariate analysis (P &lt;= 0.0097) and also served as an independent prognosticator indicating shorter DSS and LRFS interval in multivariate analysis (hazard ratio (HR) = 3.413, 95% confidence interval (CI): 1.349-8.633; HR = 4.533, 95% CI: 1.499-13.708, respectively).	dss	78-81	dual oxidase 2	Homo sapiens	13-18
28928864-8	2017	Furthermore, DUOX2 high expression was significantly associated with inferior DSS, LRFS and MeFS in univariate analysis (P &lt;= 0.0097) and also served as an independent prognosticator indicating shorter DSS and LRFS interval in multivariate analysis (hazard ratio (HR) = 3.413, 95% confidence interval (CI): 1.349-8.633; HR = 4.533, 95% CI: 1.499-13.708, respectively).	dss	205-208	dual oxidase 2	Homo sapiens	13-18
28955789-10	2017	After third DSS treatment, only the expressions of Tlr3 and Tlr4 were significantly enhanced.	dss	12-15	toll-like receptor 3	Mus musculus	51-55
28955789-10	2017	After third DSS treatment, only the expressions of Tlr3 and Tlr4 were significantly enhanced.	dss	12-15	toll-like receptor 4	Mus musculus	60-64
28883695-10	2017	Endoplasmic reticulum (ER) stress and the nuclear factor-kappa B (NF-kappaB) pathway were reduced in mice infected with S. japonicum cercariae and treated with DSS, along with ameliorated celluar apoptosis, in contrast to mice treated with DSS alone.	dss	160-163	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	42-64
28883695-10	2017	Endoplasmic reticulum (ER) stress and the nuclear factor-kappa B (NF-kappaB) pathway were reduced in mice infected with S. japonicum cercariae and treated with DSS, along with ameliorated celluar apoptosis, in contrast to mice treated with DSS alone.	dss	160-163	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
28883695-10	2017	Endoplasmic reticulum (ER) stress and the nuclear factor-kappa B (NF-kappaB) pathway were reduced in mice infected with S. japonicum cercariae and treated with DSS, along with ameliorated celluar apoptosis, in contrast to mice treated with DSS alone.	dss	240-243	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	66-75
28817583-10	2017	RESULTS: Adult mice treated with DSS exhibited colonic inflammation with significantly increased Cxcl2 mRNA expression.	dss	33-36	chemokine (C-X-C motif) ligand 2	Mus musculus	97-102
28817583-12	2017	Comparative analysis of neonatal mice revealed a significantly increased lesion size and intestinal Cxcl2 mRNA expression after DSS exposure.	dss	128-131	chemokine (C-X-C motif) ligand 2	Mus musculus	100-105
28978000-8	2017	PD-L1 expression on TCs in primary tumors (IC2/3 vs. IC0, median: 3.2 vs. 13.8 months, p=0.019) and metastatic sites (IC2/3 vs. IC0, median: 6.1 vs. 21.8 months, p=0.014) was associated with poor chemo-response, represented by significant shortened DSS.	dss	249-252	CD274 molecule	Homo sapiens	0-5
28405720-0	2017	Ceramide synthase 2 deficiency aggravates AOM-DSS-induced colitis in mice: role of colon barrier integrity.	dss	46-49	ceramide synthase 2	Mus musculus	0-19
28405720-4	2017	CerS2-/- mice developed more severe disease than CerS2+/+ mice in acute DSS and chronic AOM/DSS colitis.	dss	72-75	ceramide synthase 2	Mus musculus	0-5
28560813-7	2017	Among p16-negative patients, positive margins and dysplasia at margins predicted significantly worse DSS.	dss	101-104	cyclin dependent kinase inhibitor 2A	Homo sapiens	6-9
28601023-4	2017	Also histologic disturbances and changes of NF-kappaB and MAPK pathways including phosphorylation of IkappaB kinase, ERK1/2, SAPK/JNK and p38 were observed in the colon of the DSS mice.	dss	176-179	mitogen-activated protein kinase 3	Mus musculus	117-123
28719542-3	2017	We found that Cideb was upregulated in the colonic mucosa of both UC patients and dextran sodium sulfate (DSS)-induced mouse colitis, but its roles in the pathogenesis of UC are still ill-defined.	dss	106-109	cell death inducing DFFA like effector b	Homo sapiens	14-19
28719542-6	2017	RESULTS: Our present data indicated that Cideb-null mice were more susceptible to DSS-induced colitis, and consumption of a high-fat diet exacerbated the deterioration of DSS-induced colitis in Cideb-null mice.	dss	82-85	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	Mus musculus	41-46
28719542-6	2017	RESULTS: Our present data indicated that Cideb-null mice were more susceptible to DSS-induced colitis, and consumption of a high-fat diet exacerbated the deterioration of DSS-induced colitis in Cideb-null mice.	dss	171-174	cell death-inducing DNA fragmentation factor, alpha subunit-like effector B	Mus musculus	194-199
28532068-2	2017	In particular, the statherin phosphopeptide DpSpSEEKFLR (DSS) was found to adsorb to enamel-like hydroxyapatite and inhibit plaque-related crystal formation.	dss	57-60	statherin	Homo sapiens	19-28
28656210-0	2017	Pretreatment with bacterial components promotes DSS-injured colonic epithelial repair through the activation of STAT-3.	dss	48-51	signal transducer and activator of transcription 3	Homo sapiens	112-118
28765647-2	2017	We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis.	dss	122-125	fibroblast growth factor 2	Mus musculus	31-35
28765647-2	2017	We have recently reported that FGF2 cooperates with IL-17 to protect intestinal epithelium during dextran sodium sulfate (DSS)-induced colitis.	dss	122-125	interleukin 17A	Mus musculus	52-57
28770104-8	2017	For IS0, IS1, IS2, IS3 and IS4, respectively, the 5-year disease-free survival (DFS) rates were 59, 68, 78, 83 and 94% (p &lt; 0.001); 5-year disease-specific survival (DSS) rates were 47, 55, 75, 80, and 89% (p &lt; 0.001); and 5-year overall survival (OS) rates were 40, 44, 66, 61, and 76% (p &lt; 0.001).	dss	169-172	IS4	Homo sapiens	27-30
28562346-8	2017	We found that DSS reduced daily weight gain, suppressed antioxidant enzyme expression, increased histopathology scores and activated NF-kappaB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling.	dss	14-17	nuclear factor, erythroid derived 2, like 2	Mus musculus	228-232
28562346-8	2017	We found that DSS reduced daily weight gain, suppressed antioxidant enzyme expression, increased histopathology scores and activated NF-kappaB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling.	dss	14-17	kelch-like ECH-associated protein 1	Mus musculus	233-238
28672019-7	2017	The low PTEN expression in RCC was significantly associated with unfavorable DSS (HR = 1.568, 95% CI 1.015-2.242) in a random-effects model but not with OS (HR = 1.046, 95% CI 0.93-1.176) and PFS (HR = 1.244, 95% CI 0.907-1.704).	dss	77-80	phosphatase and tensin homolog	Homo sapiens	8-12
28672019-9	2017	This meta-analysis suggests that PTEN expression is of limited value in predicting the prognosis of patients with RCC for OS and PFS via immunohistochemistry staining analysis; and that for DSS, low PTEN expression is significantly associated with an unfavorable outcome.	dss	190-193	phosphatase and tensin homolog	Homo sapiens	199-203
28400195-13	2017	Mice with deletion of EGFR from myeloid cells formed significantly fewer and smaller tumors than the respective EGFR-expressing controls in an ApcMin/+ background as well as after administration of AOM and DSS.	dss	206-209	epidermal growth factor receptor	Mus musculus	22-26
28400195-15	2017	Furthermore, tamoxifen-induced deletion of EGFR from epithelial cells of established intestinal tumors in mice given AOM and DSS did not reduce tumor size.	dss	125-128	epidermal growth factor receptor	Mus musculus	43-47
28400195-17	2017	Mice with deletion of EGFR from myeloid cells developed more severe colitis after DSS administration, characterized by increased intestinal inflammation and intestinal barrier disruption, than control mice or mice with deletion of EGFR from intestinal epithelial cells.	dss	82-85	epidermal growth factor receptor	Mus musculus	22-26
28400195-18	2017	EGFR-deficient myeloid cells in the colon of DSS-treated LysM-Cre; Egfrf/f mice had reduced expression of interleukin 6 (IL6), and epithelial STAT3 activation was reduced compared with controls.	dss	45-48	epidermal growth factor receptor	Mus musculus	0-4
28400195-18	2017	EGFR-deficient myeloid cells in the colon of DSS-treated LysM-Cre; Egfrf/f mice had reduced expression of interleukin 6 (IL6), and epithelial STAT3 activation was reduced compared with controls.	dss	45-48	lysozyme 2	Mus musculus	57-61
28400195-18	2017	EGFR-deficient myeloid cells in the colon of DSS-treated LysM-Cre; Egfrf/f mice had reduced expression of interleukin 6 (IL6), and epithelial STAT3 activation was reduced compared with controls.	dss	45-48	interleukin 6	Mus musculus	106-119
28400195-18	2017	EGFR-deficient myeloid cells in the colon of DSS-treated LysM-Cre; Egfrf/f mice had reduced expression of interleukin 6 (IL6), and epithelial STAT3 activation was reduced compared with controls.	dss	45-48	interleukin 6	Mus musculus	121-124
28400195-18	2017	EGFR-deficient myeloid cells in the colon of DSS-treated LysM-Cre; Egfrf/f mice had reduced expression of interleukin 6 (IL6), and epithelial STAT3 activation was reduced compared with controls.	dss	45-48	signal transducer and activator of transcription 3	Mus musculus	142-147
28400195-19	2017	Administration of recombinant IL6 to LysM-Cre; Egfrf/f mice given DSS protected them from weight loss and restored epithelial proliferation and STAT3 activation, compared with administration of DSS alone to these mice.	dss	66-69	interleukin 6	Mus musculus	30-33
28400195-19	2017	Administration of recombinant IL6 to LysM-Cre; Egfrf/f mice given DSS protected them from weight loss and restored epithelial proliferation and STAT3 activation, compared with administration of DSS alone to these mice.	dss	66-69	lysozyme 2	Mus musculus	37-41
28400195-19	2017	Administration of recombinant IL6 to LysM-Cre; Egfrf/f mice given DSS protected them from weight loss and restored epithelial proliferation and STAT3 activation, compared with administration of DSS alone to these mice.	dss	66-69	signal transducer and activator of transcription 3	Mus musculus	144-149
28400195-19	2017	Administration of recombinant IL6 to LysM-Cre; Egfrf/f mice given DSS protected them from weight loss and restored epithelial proliferation and STAT3 activation, compared with administration of DSS alone to these mice.	dss	194-197	interleukin 6	Mus musculus	30-33
28199527-3	2017	We here studied the role of PRDX6 in acute and chronic dextran sodium sulphate [DSS]-induced colitis.	dss	80-83	peroxiredoxin 6	Mus musculus	28-33
28199527-9	2017	Results: Prdx6-/- mice exposed to acute and chronic DSS showed a significant decrease in the clinical parameters and in colonic expression of pro-inflammatory cytokines compared with WT mice.	dss	52-55	peroxiredoxin 6	Mus musculus	9-14
28199527-10	2017	mRNA expression of antioxidant enzymes in colon samples was significantly increased in Prdx6-/- compared with WT mice exposed to acute and chronic DSS.	dss	147-150	peroxiredoxin 6	Mus musculus	87-92
28199527-11	2017	In addition, total GSH levels were increased in Prdx6-/- mice treated with DSS in comparison with WT.	dss	75-78	peroxiredoxin 6	Mus musculus	48-53
27805617-7	2017	In a dextran sodium sulfate (DSS) acute colitis mouse model, oral administration of CTBp protected against colon mucosal damage as manifested by mitigated body weight loss, decreased histopathological scores, and blunted escalation of inflammatory cytokine levels while inducing wound healing-related genes.	dss	29-32	phosphate cytidylyltransferase 1, choline, beta isoform	Mus musculus	84-88
27805617-8	2017	Furthermore, biweekly oral administration of CTBp significantly reduced disease severity and tumorigenesis in the azoxymethane/DSS model of ulcerative colitis and colon cancer.	dss	127-130	phosphate cytidylyltransferase 1B, choline	Homo sapiens	45-49
27848951-4	2017	Remarkably, Nod2 deletion improved both chronic cobblestone ileitis (by 50% assessed, as the % of abnormal mucosa at 24 wks of age), as well as acute dextran sodium sulfate (DSS) colitis.	dss	174-177	nucleotide-binding oligomerization domain containing 2	Mus musculus	12-16
28012116-8	2017	In accordance, high CGA levels were correlated with poor DSS.	dss	57-60	chromogranin A	Homo sapiens	20-23
28012116-9	2017	In clinically localized cases, CGA levels alone were not prognostic, but its dichotomized combinations with PSA or MMP7 were independently associated with DSS (HR: 4.88, 95% CI: 1.35-17.71, p = 0.016, HR: 7.46, 1.65-33.63, p = 0.009, respectively).	dss	155-158	chromogranin A	Homo sapiens	31-34
28012116-9	2017	In clinically localized cases, CGA levels alone were not prognostic, but its dichotomized combinations with PSA or MMP7 were independently associated with DSS (HR: 4.88, 95% CI: 1.35-17.71, p = 0.016, HR: 7.46, 1.65-33.63, p = 0.009, respectively).	dss	155-158	aminopeptidase puromycin sensitive	Homo sapiens	108-111
28012116-9	2017	In clinically localized cases, CGA levels alone were not prognostic, but its dichotomized combinations with PSA or MMP7 were independently associated with DSS (HR: 4.88, 95% CI: 1.35-17.71, p = 0.016, HR: 7.46, 1.65-33.63, p = 0.009, respectively).	dss	155-158	matrix metallopeptidase 7	Homo sapiens	115-119
28938655-5	2017	Overall, low expression of TUSC7 was associated with significantly unfavorable overall survival (OS) (HR = 2.90, 95% CI: 2.12-3.98, P &lt; 0.001), disease free survival (DFS) (HR = 2.00, 95% CI: 1.49-2.68, P &lt; 0.001) and disease-specific survival (DSS) (HR = 2.57, 95% CI: 1.23-5.39, P = 0.012) in tumors patients.	dss	251-254	tumor suppressor candidate 7	Homo sapiens	27-32
28775784-9	2017	In multivariate analyses, HOXC6 expression still remained prognostically independent to portend worse DSS (p=0.015, hazard ratio=1.988) and MeFS (p=0.036, hazard ratio=1.899), together with stage III-IV (p=0.024, DSS; p=0.043, MeFS).	dss	102-105	homeobox C6	Homo sapiens	26-31
28775784-9	2017	In multivariate analyses, HOXC6 expression still remained prognostically independent to portend worse DSS (p=0.015, hazard ratio=1.988) and MeFS (p=0.036, hazard ratio=1.899), together with stage III-IV (p=0.024, DSS; p=0.043, MeFS).	dss	213-216	homeobox C6	Homo sapiens	26-31
28423466-0	2017	Zonulin transgenic mice show altered gut permeability and increased morbidity/mortality in the DSS colitis model.	dss	95-98	haptoglobin	Mus musculus	0-7
27569289-3	2017	RESULTS: Disease-specific survival (DSS) for the CAI group was 70.1% (PS) and 38.4% (CRT), and 76.6% and 46% for the STI group, respectively.	dss	36-39	carbonic anhydrase 1	Homo sapiens	49-52
28320072-4	2017	EXPERIMENTAL APPROACH: CAR expression was assessed in intestinal mucosal biopsies obtained from CD and UC patients, and in C57/Bl6 mice exposed to dextran sulphate sodium (DSS; 3.5% w/v in drinking water) to evoke intestinal inflammation and tissue damage.	dss	172-175	nuclear receptor subfamily 1 group I member 3	Homo sapiens	23-26
28320072-5	2017	CAR-deficient mice were exposed to DSS and mucosal healing assessed.	dss	35-38	nuclear receptor subfamily 1, group I, member 3	Mus musculus	0-3
28320072-9	2017	This was reproduced in our DSS studies, where CAR expression was reduced in colitic mice.	dss	27-30	nuclear receptor subfamily 1, group I, member 3	Mus musculus	46-49
28320072-10	2017	CAR-deficient mice exhibited reduced healing following DSS exposure.	dss	55-58	nuclear receptor subfamily 1, group I, member 3	Mus musculus	0-3
28449192-0	2017	Anti-Inflammatory Effects of PEGylated Human Adrenomedullin in a Mouse DSS-Induced Colitis Model.	dss	71-74	adrenomedullin	Homo sapiens	45-59
28558958-10	2017	Multivariate analysis of loss of Ep-CAM expression correlated with a poor prognosis in disease-free survival (DFS), disease-specific survival (DSS), and overall survival (OS).	dss	143-146	epithelial cell adhesion molecule	Homo sapiens	33-39
28570699-5	2017	Patients with low E-cadherin expression had poor disease-specific survival (DSS).	dss	76-79	cadherin 1	Homo sapiens	18-28
28570699-6	2017	Conversely, positive N-cadherin and higher Vimentin expression levels were associated with poor DSS and disease-free survival.	dss	96-99	cadherin 2	Homo sapiens	21-31
28570699-6	2017	Conversely, positive N-cadherin and higher Vimentin expression levels were associated with poor DSS and disease-free survival.	dss	96-99	vimentin	Homo sapiens	43-51
28570699-7	2017	Notably, our multivariate Cox regression model indicated that high Vimentin expression was an adverse prognostic factor for DSS in TSCC patients, even after the adjustment for cell differentiation, pathological stage, and expression levels of Snail, Twist, E-cadherin, and N-cadherin.	dss	124-127	vimentin	Homo sapiens	67-75
28561062-3	2017	We find similar colonic gene expression profiles in wild type and MMP-9 knockout mice in control and acute DSS conditions with the exception of eleven genes involved in antimicrobial response during colitis.	dss	107-110	matrix metallopeptidase 9	Mus musculus	66-71
28881666-10	2017	High CK2alpha expression was with significantly poorer DSS compared with low expression one (P&lt;0.001).	dss	55-58	casein kinase 2 alpha 2	Homo sapiens	5-13
28638446-8	2017	Expression levels of TCN1 were further correlated with clinicopathologic features, therapeutic response, tumor regression grade (TRG) and survivals including metastasis-free survival (MeFS), disease-specific survival (DSS) and recurrent-free survival (LRFS).	dss	218-221	transcobalamin 1	Homo sapiens	21-25
28638446-10	2017	In survival analyses, TCN1 overexpression was significantly associated with shorter DSS (p&lt;0.0001), MeFS (p=0.0002) and LRFS (p=0.0001).	dss	84-87	transcobalamin 1	Homo sapiens	22-26
28484281-0	2017	Intestinal Epithelial Cell-Specific Deletion of PLD2 Alleviates DSS-Induced Colitis by Regulating Occludin.	dss	64-67	phospholipase D2	Mus musculus	48-52
28484281-7	2017	We show that the knockout of Pld2 confers protection against dextran sodium sulphate (DSS)-induced colitis in mice.	dss	86-89	phospholipase D2	Mus musculus	29-33
28484281-8	2017	Treatment with DSS induced the expression of PLD2 and downregulated occludin in colon epithelial cells.	dss	15-18	phospholipase D2	Mus musculus	45-49
28484281-8	2017	Treatment with DSS induced the expression of PLD2 and downregulated occludin in colon epithelial cells.	dss	15-18	occludin	Mus musculus	68-76
28484281-10	2017	Additionally, we have shown that treatment with an inhibitor of PLD2 can rescue mice from DSS-induced colitis.	dss	90-93	phospholipase D2	Mus musculus	64-68
28213783-6	2017	Among patients without distant metastases (n = 282), a high pretreatment PTEN mRNA level was associated with inferior relapse-free (RFS; p = 0.001) and disease-specific survival (DSS; p = 0.003).	dss	179-182	phosphatase and tensin homolog	Homo sapiens	73-77
28213783-7	2017	Notably, this association was limited to patients harboring TP53 wild-type tumors (RFS; p = 0.003, DSS; p = 0.009).	dss	99-102	tumor protein p53	Homo sapiens	60-64
28389570-10	2017	As seen in human patients, Bves was underexpressed in experimental inflammatory carcinogenesis, and Bves-/- mice had increased tumour multiplicity and degree of dysplasia after AOM/DSS administration.	dss	181-184	blood vessel epicardial substance	Homo sapiens	100-104
28282584-9	2017	These results suggest that pomegranate polyphenols attenuated DSS-induced colitis by modulating the miR-145/p70S6K/HIF1alpha axis, indicating potential use in therapeutic treatment of ulcerative colitis.	dss	62-65	microRNA 145	Homo sapiens	100-107
27856382-15	2017	The median OS and DSS for EWS were 3.9 and 4.3 years, respectively.	dss	18-21	EWS RNA binding protein 1	Homo sapiens	26-29
28522908-10	2017	In acute DSS-induced murine colitis, CEUS targeted against MAdCAM-1 detected and differentiated stages of mild, moderate and severe colitis via calculation of mean pixel contrast intensity in decibel (9.6 dB +- 1.6 vs 12.9 dB +- 1.4 vs 18 dB +- 3.33, P &lt; 0.05).	dss	9-12	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	59-67
28522908-11	2017	Employing the AOM/DSS-induced carcinogenesis model, tumor development was monitored by CEUS targeted against VEGF and detected a significantly increased echogenicity in tumors as compared to adjacent healthy mucosa (healthy mucosa, 1.6 dB +- 1.4 vs 42 d, 18.2 dB +- 3.3 vs 84 d, 18.6 dB +- 4.9, P &lt; 0.01).	dss	18-21	vascular endothelial growth factor A	Mus musculus	109-113
28447576-7	2017	In patients with RCC, elevated serum VEGF level was not associated with OS (pooled hazard ratio [HR] = 1.16; 95% confidence interval [CI]: 0.52 to 2.60; p = 0.716), but was associated with poor DSS (pooled HR = 4.22; 95% CI: 2.02 to 8.79; p &lt; 0.001) and PFS (pooled HR = 1.50; 95% CI: 1.22 to 1.85; p &lt; 0.001).	dss	194-197	vascular endothelial growth factor A	Homo sapiens	37-41
28447576-9	2017	Tumor VEGF expression was not associated with OS (pooled HR = 1.48; 95% CI: 0.74 to 2.95; p = 0.263), but was associated with worse DSS (pooled HR = 1.83; 95% CI: 1.24 to 2.71; p = 0.003).	dss	132-135	vascular endothelial growth factor A	Homo sapiens	6-10
28447576-10	2017	CONCLUSION: In patients with RCC, elevated serum VEGF level is associated with worse OS, DSS, and PFS, while tumor expression is only associated with worse DSS.	dss	89-92	vascular endothelial growth factor A	Homo sapiens	49-53
28383063-0	2017	Rosmarinic acid suppresses colonic inflammation in dextran sulphate sodium (DSS)-induced mice via dual inhibition of NF-kappaB and STAT3 activation.	dss	76-79	signal transducer and activator of transcription 3	Mus musculus	131-136
28383063-7	2017	In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis.	dss	166-169	interleukin 6	Mus musculus	89-93
28383063-7	2017	In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis.	dss	166-169	interleukin 1 beta	Mus musculus	95-103
28383063-7	2017	In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis.	dss	166-169	interleukin 22	Mus musculus	109-114
28383063-7	2017	In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis.	dss	166-169	cytochrome c oxidase II, mitochondrial	Mus musculus	138-143
28383063-7	2017	In addition, RA resulted in the reduction of the inflammatory-related cytokines, such as IL-6, IL-1beta, and IL-22, and protein levels of COX-2 and iNOS in mice with DSS-induced colitis.	dss	166-169	nitric oxide synthase 2, inducible	Mus musculus	148-152
28638741-0	2017	Innate gammadeltaT17 cells play a protective role in DSS-induced colitis via recruitment of Gr-1+CD11b+ myeloid suppressor cells.	dss	53-56	integrin subunit alpha M	Homo sapiens	97-102
28638741-6	2017	In the current study, we found that TCR delta-deficient mice had a more severe dextran sodium sulfate (DSS)-induced colitis that was reduced upon reconstitution of gammadeltaT17 cells but not IFNgamma-producing gammadelta T cells.	dss	103-106	T cell receptor delta chain	Mus musculus	36-45
28638741-7	2017	Immunophenotyping of the cellular infiltrate upon DSS-induced colitis showed a reduced infiltration of Gr-1+CD11b+ myeloid cells into the sites of inflammation in mice lacking gammadeltaT17 cells.	dss	50-53	integrin subunit alpha M	Homo sapiens	108-113
28638741-10	2017	Depletion of Gr-1+CD11b+ myeloid cells resulted in an increase severity of DSS-induced colitis.	dss	75-78	integrin subunit alpha M	Homo sapiens	18-23
28079248-7	2017	KEY RESULTS: The dinitrate-barbiturate inhibited the induction and activity of MMP-9 during DSS colitis in the rat.	dss	92-95	matrix metallopeptidase 9	Rattus norvegicus	79-84
26833290-7	2017	RESULTS: DSS induced significant body weight loss, morphological changes in the colon, increased myeloperoxidase (MPO) activity and up-regulated colonic mRNA expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-12 and monocyte chemoattractant protein (MCP)-1, as well as associated histological changes.	dss	9-12	myeloperoxidase	Mus musculus	97-112
26833290-7	2017	RESULTS: DSS induced significant body weight loss, morphological changes in the colon, increased myeloperoxidase (MPO) activity and up-regulated colonic mRNA expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-12 and monocyte chemoattractant protein (MCP)-1, as well as associated histological changes.	dss	9-12	myeloperoxidase	Mus musculus	114-117
26833290-7	2017	RESULTS: DSS induced significant body weight loss, morphological changes in the colon, increased myeloperoxidase (MPO) activity and up-regulated colonic mRNA expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-12 and monocyte chemoattractant protein (MCP)-1, as well as associated histological changes.	dss	9-12	tumor necrosis factor	Mus musculus	172-205
26833290-7	2017	RESULTS: DSS induced significant body weight loss, morphological changes in the colon, increased myeloperoxidase (MPO) activity and up-regulated colonic mRNA expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-12 and monocyte chemoattractant protein (MCP)-1, as well as associated histological changes.	dss	9-12	interleukin 6	Mus musculus	207-225
26833290-7	2017	RESULTS: DSS induced significant body weight loss, morphological changes in the colon, increased myeloperoxidase (MPO) activity and up-regulated colonic mRNA expression of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-12 and monocyte chemoattractant protein (MCP)-1, as well as associated histological changes.	dss	9-12	chemokine (C-C motif) ligand 2	Mus musculus	237-277
27960043-9	2017	Incorporation of LODDS into the prognostic model based on the seventh edition of the TNM classification significantly improved discriminative performance for 5-year DSS with a lower AIC (1883 versus 1897), and higher prediction accuracy (Harrell"s c-statistic: 0.768 versus 0.764).	dss	165-168	teneurin transmembrane protein 1	Homo sapiens	85-88
28219937-8	2017	TERT promoter mutation was significantly associated with unfavorable DSS (HR = 7.64; 95% CI = 4.00-14.61) and DFS (HR = 2.98; 95% CI = 2.27-3.92).	dss	69-72	telomerase reverse transcriptase	Homo sapiens	0-4
28290606-12	2017	The immunohistochemistry results revealed that DSS significantly enhanced the expression of Bcl-2, and inhibited the expression of Bax and caspase-3 in the brain in comparison to the model group.	dss	47-50	BCL2, apoptosis regulator	Rattus norvegicus	92-97
28290606-12	2017	The immunohistochemistry results revealed that DSS significantly enhanced the expression of Bcl-2, and inhibited the expression of Bax and caspase-3 in the brain in comparison to the model group.	dss	47-50	BCL2 associated X, apoptosis regulator	Rattus norvegicus	131-134
28290606-12	2017	The immunohistochemistry results revealed that DSS significantly enhanced the expression of Bcl-2, and inhibited the expression of Bax and caspase-3 in the brain in comparison to the model group.	dss	47-50	caspase 3	Rattus norvegicus	139-148
27513455-7	2017	RESULTS: The severity of inflammation in DSS-induced colitis increased markedly in CGRP8-37 -treated mice and RAMP1-/- mice compared with WT mice.	dss	41-44	receptor (calcitonin) activity modifying protein 1	Mus musculus	110-115
27513455-13	2017	CONCLUSIONS: The findings of this study suggest that RAMP1 exerted mucosal protection in DSS-induced colitis via attenuation of recruitment of inflammatory cells and of pro-inflammatory cytokines.	dss	89-92	receptor (calcitonin) activity modifying protein 1	Mus musculus	53-58
28351587-7	2017	The 5-year DSS and OS rates of buccal SCC patients were slightly higher than those of tongue SCC (78% vs. 77%, p=0.0297; and 71% vs. 69%, p=0.0231, respectively).	dss	11-14	serpin family B member 3	Homo sapiens	38-41
28295446-9	2017	Also, IL-10 and TGF-B gene overexpression was observed in rAl-CPI-treated group compared to DSS-exposed control and healthy mice.	dss	92-95	interleukin 10	Mus musculus	6-11
28295446-9	2017	Also, IL-10 and TGF-B gene overexpression was observed in rAl-CPI-treated group compared to DSS-exposed control and healthy mice.	dss	92-95	transforming growth factor, beta 1	Mus musculus	16-21
27782738-7	2017	The DSS group had higher concentrations and mRNA abundances (p&lt;0.05) of TNF-alpha and IL-6 in the jejunal and colonic tissues compared with the control group.	dss	4-7	tumor necrosis factor	Sus scrofa	75-84
27782738-7	2017	The DSS group had higher concentrations and mRNA abundances (p&lt;0.05) of TNF-alpha and IL-6 in the jejunal and colonic tissues compared with the control group.	dss	4-7	interleukin 6	Sus scrofa	89-93
27782738-8	2017	Colonic concentration and mRNA abundance of IL-10 were reduced (p&lt;0.05), however, jejunal IL-10 mRNA abundance was increased (p&lt;0.05) in the DSS group compared with the control group.	dss	147-150	IL10	Sus scrofa	44-49
27782738-8	2017	Colonic concentration and mRNA abundance of IL-10 were reduced (p&lt;0.05), however, jejunal IL-10 mRNA abundance was increased (p&lt;0.05) in the DSS group compared with the control group.	dss	147-150	IL10	Sus scrofa	93-98
27782738-9	2017	In conclusion, administration of DSS at 1.25 g/kg BW for 10 days respectively induced acute inflammation in the jejunum and chronic inflammation and ulcerative colitis in the colon with substantially decreased colonic concentration and mRNA abundance of IL-10 in the young pigs, mimicking the IL-10 expression pattern in humans Associated with chronic bowel inflammation.	dss	33-36	IL10	Sus scrofa	254-259
27782738-9	2017	In conclusion, administration of DSS at 1.25 g/kg BW for 10 days respectively induced acute inflammation in the jejunum and chronic inflammation and ulcerative colitis in the colon with substantially decreased colonic concentration and mRNA abundance of IL-10 in the young pigs, mimicking the IL-10 expression pattern in humans Associated with chronic bowel inflammation.	dss	33-36	IL10	Sus scrofa	293-298
28350804-6	2017	Utilizing a mouse model of colitis-related colon carcinoma induced by the carcinogen azoxymethane (AOM), followed by the inflammatory agent dextran sodium sulfate (DSS), we found that Sdc1 deficiency results in increased susceptibility to colitis-associated tumorigenesis.	dss	164-167	syndecan 1	Mus musculus	184-188
28273458-6	2017	Consequently, deletion of the RIPK3 RHIM in CD11c+ cells alone was sufficient to impair dextran sodium sulfate (DSS)-induced interleukin (IL)-23 and IL-1beta expression, leading to severe intestinal inflammation.	dss	112-115	receptor interacting serine/threonine kinase 3	Homo sapiens	30-35
28273458-6	2017	Consequently, deletion of the RIPK3 RHIM in CD11c+ cells alone was sufficient to impair dextran sodium sulfate (DSS)-induced interleukin (IL)-23 and IL-1beta expression, leading to severe intestinal inflammation.	dss	112-115	integrin subunit alpha X	Homo sapiens	44-49
28273458-6	2017	Consequently, deletion of the RIPK3 RHIM in CD11c+ cells alone was sufficient to impair dextran sodium sulfate (DSS)-induced interleukin (IL)-23 and IL-1beta expression, leading to severe intestinal inflammation.	dss	112-115	interleukin 1 beta	Homo sapiens	149-157
28259136-5	2017	RESULTS: Compared with the control treatment, DSS treatment significantly (p &lt; 0.05) decreased body weight change, colonic length, duodenal villus height and expression of zonula occludens-1, whereas significantly (p &lt; 0.05) increased colonic damage score and expression of claudin-1, interleukin (IL)-1, IL-7, IL-10, interferon-gamma and tumour necrosis factor (TNF)-alpha in colon.	dss	46-49	claudin 1	Rattus norvegicus	280-289
28259136-5	2017	RESULTS: Compared with the control treatment, DSS treatment significantly (p &lt; 0.05) decreased body weight change, colonic length, duodenal villus height and expression of zonula occludens-1, whereas significantly (p &lt; 0.05) increased colonic damage score and expression of claudin-1, interleukin (IL)-1, IL-7, IL-10, interferon-gamma and tumour necrosis factor (TNF)-alpha in colon.	dss	46-49	interleukin 7	Rattus norvegicus	311-315
28259136-5	2017	RESULTS: Compared with the control treatment, DSS treatment significantly (p &lt; 0.05) decreased body weight change, colonic length, duodenal villus height and expression of zonula occludens-1, whereas significantly (p &lt; 0.05) increased colonic damage score and expression of claudin-1, interleukin (IL)-1, IL-7, IL-10, interferon-gamma and tumour necrosis factor (TNF)-alpha in colon.	dss	46-49	interleukin 10	Rattus norvegicus	317-322
28259136-5	2017	RESULTS: Compared with the control treatment, DSS treatment significantly (p &lt; 0.05) decreased body weight change, colonic length, duodenal villus height and expression of zonula occludens-1, whereas significantly (p &lt; 0.05) increased colonic damage score and expression of claudin-1, interleukin (IL)-1, IL-7, IL-10, interferon-gamma and tumour necrosis factor (TNF)-alpha in colon.	dss	46-49	interferon gamma	Rattus norvegicus	324-340
28259136-5	2017	RESULTS: Compared with the control treatment, DSS treatment significantly (p &lt; 0.05) decreased body weight change, colonic length, duodenal villus height and expression of zonula occludens-1, whereas significantly (p &lt; 0.05) increased colonic damage score and expression of claudin-1, interleukin (IL)-1, IL-7, IL-10, interferon-gamma and tumour necrosis factor (TNF)-alpha in colon.	dss	46-49	tumor necrosis factor	Rattus norvegicus	345-379
27921309-4	2017	We report here that the expression of HIF-1alpha and IL-33 was increased significantly in the inflamed mucosa of IBD patients as well as mice with colitis induced by dextran sulphate sodium (DSS).	dss	191-194	hypoxia inducible factor 1 subunit alpha	Homo sapiens	38-48
27921309-4	2017	We report here that the expression of HIF-1alpha and IL-33 was increased significantly in the inflamed mucosa of IBD patients as well as mice with colitis induced by dextran sulphate sodium (DSS).	dss	191-194	interleukin 33	Homo sapiens	53-58
27816392-7	2017	A combined low S-PD-L1 and T-PD-1 was associated with poor survival in all patients (DSS: hazard ratio [HR], 1.81; 95% confidence interval [CI], 1.37-2.40; P &lt; .001) at both centers and for all pathologic stages.	dss	85-88	CD274 molecule	Homo sapiens	17-22
27816392-7	2017	A combined low S-PD-L1 and T-PD-1 was associated with poor survival in all patients (DSS: hazard ratio [HR], 1.81; 95% confidence interval [CI], 1.37-2.40; P &lt; .001) at both centers and for all pathologic stages.	dss	85-88	programmed cell death 1	Homo sapiens	29-33
28103562-5	2017	For these reasons this manuscript presents a DSS detecting the onset of worrisome events in COPD subjects.	dss	45-48	COPD	Homo sapiens	92-96
27942903-8	2017	RESULTS: CX3CR1 was upregulated in DSS colitis and LPS-induced sepsis.	dss	35-38	chemokine (C-X3-C motif) receptor 1	Mus musculus	9-15
29259703-6	2017	Main body of abstract: Among each PG receptor subtype examined, prostaglandin E receptor 2 (EP2) signaling specifically contributes to colorectal cancer formation and inflammation in lesions of AOM-DSS model.	dss	198-201	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	92-95
29259703-13	2017	Indeed, in AOM-DSS model, a selective EP2 antagonist, PF-04418948, potently suppresses colorectal tumor formation.	dss	15-18	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	38-41
27981571-4	2017	Here, we demonstrated that Phd1 deletion in endothelial and haematopoietic cells (Phd1f/f Tie2:cre) protected mice from dextran sulphate sodium (DSS)-induced colitis, with reduced epithelial erosions, immune cell infiltration, and colonic microvascular dysfunction, whereas the response of Phd2f/+ Tie2:cre and Phd3f/f Tie2:cre mice to DSS was similar to that of their littermate controls.	dss	145-148	egl-9 family hypoxia-inducible factor 2	Mus musculus	27-31
27981571-4	2017	Here, we demonstrated that Phd1 deletion in endothelial and haematopoietic cells (Phd1f/f Tie2:cre) protected mice from dextran sulphate sodium (DSS)-induced colitis, with reduced epithelial erosions, immune cell infiltration, and colonic microvascular dysfunction, whereas the response of Phd2f/+ Tie2:cre and Phd3f/f Tie2:cre mice to DSS was similar to that of their littermate controls.	dss	145-148	TEK receptor tyrosine kinase	Mus musculus	90-94
27981571-4	2017	Here, we demonstrated that Phd1 deletion in endothelial and haematopoietic cells (Phd1f/f Tie2:cre) protected mice from dextran sulphate sodium (DSS)-induced colitis, with reduced epithelial erosions, immune cell infiltration, and colonic microvascular dysfunction, whereas the response of Phd2f/+ Tie2:cre and Phd3f/f Tie2:cre mice to DSS was similar to that of their littermate controls.	dss	336-339	egl-9 family hypoxia-inducible factor 2	Mus musculus	27-31
27981571-4	2017	Here, we demonstrated that Phd1 deletion in endothelial and haematopoietic cells (Phd1f/f Tie2:cre) protected mice from dextran sulphate sodium (DSS)-induced colitis, with reduced epithelial erosions, immune cell infiltration, and colonic microvascular dysfunction, whereas the response of Phd2f/+ Tie2:cre and Phd3f/f Tie2:cre mice to DSS was similar to that of their littermate controls.	dss	336-339	TEK receptor tyrosine kinase	Mus musculus	90-94
27636117-6	2017	C-Met overexpression was significantly associated with shorter OS (HR: 2.04, 95% CI: 1.66-2.52, P&lt;0.001) and DSS (HR: 3.03, 95% CI: 2.04-4.48, P&lt;0.001) in patients with EC.	dss	112-115	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
28039905-5	2017	The levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in the blood were increased in AOM + DSS-treated mice; however, those levels were reduced by UVA eye irradiation.	dss	108-111	interleukin 6	Mus musculus	14-32
28039905-5	2017	The levels of interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in the blood were increased in AOM + DSS-treated mice; however, those levels were reduced by UVA eye irradiation.	dss	108-111	tumor necrosis factor	Mus musculus	37-70
28039905-6	2017	The expression of beta-endorphin, methionine-enkephalin (OGF), mu-opioid receptor, and opioid growth factor receptor (OGFR) of the colon was increased in the AOM + DSS-treated mice, and these levels were increased further following UVA eye irradiation.	dss	164-167	pro-opiomelanocortin-alpha	Mus musculus	18-32
28039905-6	2017	The expression of beta-endorphin, methionine-enkephalin (OGF), mu-opioid receptor, and opioid growth factor receptor (OGFR) of the colon was increased in the AOM + DSS-treated mice, and these levels were increased further following UVA eye irradiation.	dss	164-167	opioid growth factor receptor	Mus musculus	87-116
28039905-6	2017	The expression of beta-endorphin, methionine-enkephalin (OGF), mu-opioid receptor, and opioid growth factor receptor (OGFR) of the colon was increased in the AOM + DSS-treated mice, and these levels were increased further following UVA eye irradiation.	dss	164-167	opioid growth factor receptor	Mus musculus	118-122
28069814-11	2017	In dextran sodium sulfate (DSS)-induced colitis in Muc2+/+ mice, which depletes the mucus barrier and goblet cell mucin, Cramp expression was significantly enhanced during restitution.	dss	27-30	mucin 2	Mus musculus	51-55
28069814-11	2017	In dextran sodium sulfate (DSS)-induced colitis in Muc2+/+ mice, which depletes the mucus barrier and goblet cell mucin, Cramp expression was significantly enhanced during restitution.	dss	27-30	cathelicidin antimicrobial peptide	Mus musculus	121-126
28069814-12	2017	These studies demonstrate regulatory mechanisms between MUC2 and cathelicidins in the colonic mucosa where an intact mucus barrier is essential for expression and secretion of cathelicidins in response to E. histolytica- and DSS-induced colitis.	dss	225-228	mucin 2	Mus musculus	56-60
28137860-9	2017	In addition, Gatmc/c colonocytes showed increased metabolic stress in response to DSS with higher levels of phospho-AMPK and lower levels of phosphorylation of mammalian target of rapamycin (phospho-mTOR).	dss	82-85	mechanistic target of rapamycin kinase	Homo sapiens	199-203
27856419-6	2017	DSS-WT mice exhibited enhanced intestinal inflammation, polyp size, and polyp number (7.5 +- 0.8) compared with DSS-NPY-/- mice (4 +- 0.5, P &lt; 0.01).	dss	112-115	neuropeptide Y	Mus musculus	116-119
27856419-7	2017	Accordingly, DSS-WT mice also showed increased colonic epithelial proliferation (PCNA, Ki67) and reduced apoptosis (TUNEL) compared with DSS-NPY-/- mice.	dss	13-16	proliferating cell nuclear antigen	Mus musculus	81-85
27856419-7	2017	Accordingly, DSS-WT mice also showed increased colonic epithelial proliferation (PCNA, Ki67) and reduced apoptosis (TUNEL) compared with DSS-NPY-/- mice.	dss	13-16	antigen identified by monoclonal antibody Ki 67	Mus musculus	87-91
27856419-7	2017	Accordingly, DSS-WT mice also showed increased colonic epithelial proliferation (PCNA, Ki67) and reduced apoptosis (TUNEL) compared with DSS-NPY-/- mice.	dss	137-140	neuropeptide Y	Mus musculus	141-144
27856419-8	2017	The apoptosis regulating microRNA, miR-375, was significantly downregulated in the colon of DSS-WT (2-fold, P &lt; 0.01) compared with DSS-NPY-/--mice.	dss	92-95	microRNA 375	Mus musculus	35-42
27856419-8	2017	The apoptosis regulating microRNA, miR-375, was significantly downregulated in the colon of DSS-WT (2-fold, P &lt; 0.01) compared with DSS-NPY-/--mice.	dss	92-95	neuropeptide Y	Mus musculus	139-142
27856419-8	2017	The apoptosis regulating microRNA, miR-375, was significantly downregulated in the colon of DSS-WT (2-fold, P &lt; 0.01) compared with DSS-NPY-/--mice.	dss	135-138	microRNA 375	Mus musculus	35-42
27915032-3	2017	Here we determined in mice colon, by real time-PCR and immunological assays, the expression of the reelin signalling system; its response to dextran sulphate sodium (DSS) and the response of wild-type and reeler mice to DSS-treatment.	dss	166-169	reelin	Mus musculus	99-105
27915032-3	2017	Here we determined in mice colon, by real time-PCR and immunological assays, the expression of the reelin signalling system; its response to dextran sulphate sodium (DSS) and the response of wild-type and reeler mice to DSS-treatment.	dss	220-223	reelin	Mus musculus	99-105
27915032-7	2017	DSS-treatment reduces reelin expression in the muscle but it is activated in the mucosa.	dss	0-3	reelin	Mus musculus	22-28
27915032-9	2017	This indicates that the DSS-induced reelin up-regulation results from changes in the reelin gene expression rather than from myofibroblasts proliferation.	dss	24-27	reelin	Mus musculus	36-42
27915032-9	2017	This indicates that the DSS-induced reelin up-regulation results from changes in the reelin gene expression rather than from myofibroblasts proliferation.	dss	24-27	reelin	Mus musculus	85-91
27915032-10	2017	DSS-treatment does not modify Sp1 or Tbr1 mRNA abundance, but increases that of TGF-beta1 and ApoER2, decreases that of CASK and DNMT1 and it also decreases the reelin promoter methylation.	dss	0-3	transforming growth factor, beta 1	Mus musculus	80-89
27915032-10	2017	DSS-treatment does not modify Sp1 or Tbr1 mRNA abundance, but increases that of TGF-beta1 and ApoER2, decreases that of CASK and DNMT1 and it also decreases the reelin promoter methylation.	dss	0-3	low density lipoprotein receptor-related protein 8, apolipoprotein e receptor	Mus musculus	94-100
27915032-10	2017	DSS-treatment does not modify Sp1 or Tbr1 mRNA abundance, but increases that of TGF-beta1 and ApoER2, decreases that of CASK and DNMT1 and it also decreases the reelin promoter methylation.	dss	0-3	calcium/calmodulin-dependent serine protein kinase (MAGUK family)	Mus musculus	120-124
27915032-10	2017	DSS-treatment does not modify Sp1 or Tbr1 mRNA abundance, but increases that of TGF-beta1 and ApoER2, decreases that of CASK and DNMT1 and it also decreases the reelin promoter methylation.	dss	0-3	DNA methyltransferase (cytosine-5) 1	Mus musculus	129-134
27915032-10	2017	DSS-treatment does not modify Sp1 or Tbr1 mRNA abundance, but increases that of TGF-beta1 and ApoER2, decreases that of CASK and DNMT1 and it also decreases the reelin promoter methylation.	dss	0-3	reelin	Mus musculus	161-167
27750083-10	2017	Collectively, our data indicate that SP can promote the regeneration of tissue following damage by DSS treatment, possibly by modulating immune response.	dss	99-102	tachykinin 1	Mus musculus	37-39
27864128-13	2017	However, YAP-knockout mice did not regenerate colon tissues and died soon after administration of DSS.	dss	98-101	yes-associated protein 1	Mus musculus	9-12
27864128-14	2017	15-PGDH-knockout mice regenerated colon tissues more rapidly than control mice after withdrawal of DSS, and had faster recovery of body weight, colon length, and colitis histology scores.	dss	99-102	hydroxyprostaglandin dehydrogenase 15 (NAD)	Mus musculus	3-7
27707514-4	2017	In this study we investigated mice proficient or deficient for the expression of the CX3CR1 receptor in a model of dextran sulphate sodium (DSS) induced acute colitis.	dss	140-143	chemokine (C-X3-C motif) receptor 1	Mus musculus	85-91
28039805-6	2017	The highest concentrations of tissue TNFalpha were observed in groups without DSS colitis that were treated either with TNFalpha-binding L. lactis or infliximab.	dss	78-81	tumor necrosis factor	Mus musculus	37-45
27491729-7	2017	Lymph node metastasis (P = 0.037) and D-INV (P = 0.008) were independent predictors of shorter disease-specific survival (DSS).	dss	122-125	inversin	Homo sapiens	40-43
30298837-4	2018	DSS-induced colitis was significantly attenuated in TRPV4-deficient (TRPV4 KO) mice when compared to wild-type mice.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	52-57
30298837-4	2018	DSS-induced colitis was significantly attenuated in TRPV4-deficient (TRPV4 KO) mice when compared to wild-type mice.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	69-74
29064787-7	2018	Specifically, we develop a probabilistic decomposed slab-and-spike (DSS) model to perform the inference by applying a pair of decomposed spike-and-slab variables for the model coefficients, where the first variable is used to estimate the causal relationship and the second one captures the lag information among different temporal variables.	dss	68-71	stathmin 1	Homo sapiens	291-294
30298837-5	2018	Repeated intrarectal administration of GSK1016790A, a TRPV4 agonist, exacerbated the severity of DSS-induced colitis.	dss	97-100	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	54-59
28045548-9	2017	After AOM/DSS treatment, decreased plasma 25(OH)D3 levels and downregulation of vD target genes Cyp24 and Vdr were observed in both mice strains (vD-deficient or vD-supplemented diet), compared to saline-treated controls on the vD-deficient diet.	dss	10-13	cytochrome P450, family 24, subfamily a, polypeptide 1	Mus musculus	96-101
30298837-6	2018	Bone marrow transfer experiments demonstrated a dominant role of TRPV4 in non-haematopoietic cells for DSS-induced colitis.	dss	103-106	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	65-70
30298837-7	2018	DSS treatment upregulated TRPV4 expression in the vascular endothelia of colonic mucosa and submucosa.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	26-31
27920257-5	2017	Moreover, we demonstrate that the PKR inhibitor C16 ameliorates both iNOS amplification and disease-induced phenotypic breakdown of the intestinal epithelial barrier caused by an increase in extracellular osmolarity induced by dextran sodium sulfate (DSS) in vivo Collectively, these findings indicate that PKR activation is an essential part of the molecular switch from adaptation to inflammation in response to hyperosmotic stress.	dss	251-254	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	34-37
28045548-9	2017	After AOM/DSS treatment, decreased plasma 25(OH)D3 levels and downregulation of vD target genes Cyp24 and Vdr were observed in both mice strains (vD-deficient or vD-supplemented diet), compared to saline-treated controls on the vD-deficient diet.	dss	10-13	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	106-109
27888708-8	2017	A cutoff value equal to 70% could be taken as a threshold for TIL assessment, with a TIL level higher than 70% associated with a better prognosis (DFS rate: 51.9%, P = .018; DSS rate: 59.3%, P = .049).	dss	174-177	toll like receptor 1	Homo sapiens	85-88
27553076-4	2017	The current study was aimed at testing the efficacy of this GLP-1 nanomedicine in alleviating colonic inflammation and associated diarrhea in dextran sodium sulfate (DSS) induced mouse colitis model.	dss	166-169	glucagon	Mus musculus	60-65
30298837-8	2018	DSS treatment increased vascular permeability, which was abolished in TRPV4 KO mice.	dss	0-3	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	70-75
28143614-10	2017	Moreover, higher miR-129-2 independently predicted for shorter DSS and miR-34b/c methylation levels independently predicted for shorter DFS and DSS.	dss	63-66	microRNA 1292	Homo sapiens	17-26
30298837-9	2018	The DSS-induced increase in vascular permeability was further enhanced by intravenous administration of GSK1016790A, which was abrogated by a TRPV4 antagonist RN1734.	dss	4-7	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	142-147
28143614-10	2017	Moreover, higher miR-129-2 independently predicted for shorter DSS and miR-34b/c methylation levels independently predicted for shorter DFS and DSS.	dss	144-147	microRNA 34b	Homo sapiens	71-78
28056982-7	2017	Patients with high expression of FGFR1, FGFR2, or FGFR4 had significantly poorer disease-specific survival (DSS) (p = 0.009, p = 0.001, and p = 0.023, respectively).	dss	108-111	fibroblast growth factor receptor 2	Homo sapiens	40-45
27407094-11	2017	CONCLUSIONS: ALT and DAXX/ATRX loss in PanNETs was associated with shorter DFS and DSS and likely plays a significant role in driving metastatic disease.	dss	83-86	death domain associated protein	Homo sapiens	21-25
27407094-11	2017	CONCLUSIONS: ALT and DAXX/ATRX loss in PanNETs was associated with shorter DFS and DSS and likely plays a significant role in driving metastatic disease.	dss	83-86	ATRX chromatin remodeler	Homo sapiens	26-30
28056982-7	2017	Patients with high expression of FGFR1, FGFR2, or FGFR4 had significantly poorer disease-specific survival (DSS) (p = 0.009, p = 0.001, and p = 0.023, respectively).	dss	108-111	fibroblast growth factor receptor 1	Homo sapiens	33-38
28056982-7	2017	Patients with high expression of FGFR1, FGFR2, or FGFR4 had significantly poorer disease-specific survival (DSS) (p = 0.009, p = 0.001, and p = 0.023, respectively).	dss	108-111	fibroblast growth factor receptor 4	Homo sapiens	50-55
28056982-8	2017	In IGC, only FGFR4 expression was significantly associated with factors relative to tumor progression and with shorter DSS (p = 0.012).	dss	119-122	fibroblast growth factor receptor 4	Homo sapiens	13-18
28011493-6	2017	RESULTS: Podoplanin-positive status in tumor cells (n=54) was correlated with a lower incidence of lymphatic invasion (p=0.031) but there were no significant differences in disease-free survival (DFS) and disease-specific survival (DSS) by the log-rank test.	dss	232-235	podoplanin	Homo sapiens	9-19
27856416-8	2017	DSS caused injury and inflammation leading to reduced expression of BMP-4 and of BMPR1A mRNAs, and to decreased BMP signaling.	dss	0-3	bone morphogenetic protein 4	Mus musculus	68-73
27856416-8	2017	DSS caused injury and inflammation leading to reduced expression of BMP-4 and of BMPR1A mRNAs, and to decreased BMP signaling.	dss	0-3	bone morphogenetic protein receptor, type 1A	Mus musculus	81-87
27856416-10	2017	Administration of anti-TNF-alpha antibodies to DSS-treated mice ameliorated colonic inflammation and increased the expression of BMP-4 and BMPR1A mRNAs.	dss	47-50	tumor necrosis factor	Mus musculus	23-32
27856416-10	2017	Administration of anti-TNF-alpha antibodies to DSS-treated mice ameliorated colonic inflammation and increased the expression of BMP-4 and BMPR1A mRNAs.	dss	47-50	bone morphogenetic protein 4	Mus musculus	129-134
27856416-10	2017	Administration of anti-TNF-alpha antibodies to DSS-treated mice ameliorated colonic inflammation and increased the expression of BMP-4 and BMPR1A mRNAs.	dss	47-50	bone morphogenetic protein receptor, type 1A	Mus musculus	139-145
28011493-7	2017	Podoplanin-positive status in CAFs (n=41) was correlated with more advanced stage (p=0.008), higher frequency of pleural invasion (p=0.002) and both shorter DFS (p=0.006) and DSS (p=0.006).	dss	175-178	podoplanin	Homo sapiens	0-10
28011493-8	2017	In Cox"s multivariate analysis, podoplanin-positive status in CAFs was an independent negative prognostic factor for DFS (p=0.027) and DSS (p=0.027).	dss	135-138	podoplanin	Homo sapiens	32-42
28968599-9	2017	The same association was also observed between PVT1 expression with outcomes, including disease free survival (DFS), disease specific survival (DSS) and relapse free survival (RFS).	dss	144-147	Pvt1 oncogene	Homo sapiens	47-51
27510419-7	2017	Four-day treatment with dextran sulphate sodium (DSS) triggered colon inflammation, as evidenced by an increase in local IL6 and mKC mRNA levels, but did not affect the gross architecture of colonic epithelium.	dss	49-52	interleukin 6	Homo sapiens	121-124
27327245-3	2017	Here we examined the effects of an FAAH inhibitor (FAAH-II), on dextran sodium sulphate (DSS)-induced experimental colitis in mice.	dss	89-92	fatty acid amide hydrolase	Mus musculus	35-39
27327245-3	2017	Here we examined the effects of an FAAH inhibitor (FAAH-II), on dextran sodium sulphate (DSS)-induced experimental colitis in mice.	dss	89-92	fatty acid amide hydrolase	Mus musculus	51-55
28456797-11	2017	Additionally, increased ZMIZ1 and TL1A levels were detected in intestinal samples obtained from both IBD patients and DSS-treated mice.	dss	118-121	zinc finger MIZ-type containing 1	Homo sapiens	24-29
28456797-11	2017	Additionally, increased ZMIZ1 and TL1A levels were detected in intestinal samples obtained from both IBD patients and DSS-treated mice.	dss	118-121	TNF superfamily member 15	Homo sapiens	34-38
28456797-13	2017	Consistent with previous studies, TL1A expression levels were higher in Chinese Han IBD patients and DSS-treated mice.	dss	101-104	TNF superfamily member 15	Homo sapiens	34-38
27253188-5	2017	IGFBP-3 knockout mice also exhibited increased colon epithelial cell proliferation (P &lt; 0.0001) following DSS exposure.	dss	109-112	insulin-like growth factor binding protein 3	Mus musculus	0-7
29062163-6	2017	Additionally, loss of KLF4 expression was also related to a worse disease-special survival (DSS) yielding a pooled HR of 1.73 (95% CI: 1.08-2.77, P = 0.022).	dss	92-95	Kruppel like factor 4	Homo sapiens	22-26
27930969-4	2017	Moreover, rhapontin prevented DSS-induced impairment in the colon epithelium barrier by increasing the expression of tight junction proteins, such as zonula occludens-1(ZO-1) and occludin, and reduced apoptosis-associated protein (cyt-c, the ratio of bcl-2/bax and cleaved-capase9) expression in the colon.	dss	30-33	BCL2 apoptosis regulator	Homo sapiens	251-256
27930969-4	2017	Moreover, rhapontin prevented DSS-induced impairment in the colon epithelium barrier by increasing the expression of tight junction proteins, such as zonula occludens-1(ZO-1) and occludin, and reduced apoptosis-associated protein (cyt-c, the ratio of bcl-2/bax and cleaved-capase9) expression in the colon.	dss	30-33	BCL2 associated X, apoptosis regulator	Homo sapiens	257-260
27035165-8	2017	Five-year DSS was lower in NF1-associated and radiation-associated MPNST than in sporadic MPNST (52%, 47%, and 67%, respectively, p = 0.140).	dss	10-13	neurofibromin 1	Homo sapiens	27-30
27827303-0	2017	An HDAC6 Inhibitor Confers Protection and Selectively Inhibits B-Cell Infiltration in DSS-Induced Colitis in Mice.	dss	86-89	histone deacetylase 6	Mus musculus	3-8
27253188-6	2017	Semi-quantitative immunohistochemistry showed greater IGF-1 receptor activation in colon epithelial cells of IGFBP-3 knockout mice compared with control mice following DSS exposure.	dss	168-171	insulin-like growth factor 1	Mus musculus	54-59
27253188-6	2017	Semi-quantitative immunohistochemistry showed greater IGF-1 receptor activation in colon epithelial cells of IGFBP-3 knockout mice compared with control mice following DSS exposure.	dss	168-171	insulin-like growth factor binding protein 3	Mus musculus	109-116
27253188-7	2017	CONCLUSION: Our data demonstrate that IGFBP-3 influences severity of DSS-induced colitis.	dss	69-72	insulin-like growth factor binding protein 3	Mus musculus	38-45
29056830-0	2017	Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression.	dss	32-35	protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform	Mus musculus	55-59
29056830-0	2017	Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression.	dss	32-35	thymoma viral proto-oncogene 1	Mus musculus	74-77
29056830-0	2017	Aloperine Protects Mice against DSS-Induced Colitis by PP2A-Mediated PI3K/Akt/mTOR Signaling Suppression.	dss	32-35	mechanistic target of rapamycin kinase	Mus musculus	78-82
29056830-5	2017	Aloperine also effectively attenuated DSS-induced intestinal inflammation based on the pathological score and myeloperoxidase expression and activity in colon tissues.	dss	38-41	myeloperoxidase	Mus musculus	110-125
29056830-6	2017	In addition, aloperine regulated T-cell proportions and promoted Foxp3 expression in the spleens and mesenteric lymph nodes of DSS-induced colitis mice and in the spleens of the Foxp3GFP mice.	dss	127-130	forkhead box P3	Mus musculus	65-70
27959399-6	2017	The densities of chromogranin A, serotonin, peptide YY and oxyntomodulin cells were significantly higher, and those of pancreatic peptide and somatostatin cells were lower in rats with DSS-induced colitis than in the controls.	dss	185-188	chromogranin A	Rattus norvegicus	17-31
27959399-6	2017	The densities of chromogranin A, serotonin, peptide YY and oxyntomodulin cells were significantly higher, and those of pancreatic peptide and somatostatin cells were lower in rats with DSS-induced colitis than in the controls.	dss	185-188	peptide YY	Rattus norvegicus	44-54
28053542-5	2017	AZGP1 downregulation was significantly associated with lymph node metastasis (P=0.035), advanced clinical stage (P=0.018), poor prognosis for 5-year disease-specific survival (DSS; P&lt;0.001), local recurrence-free survival (LRFS; P=0.016), and metastasis-free survival (MeFS; P=0.014).	dss	176-179	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	0-5
27664423-6	2017	Molecular analysis of the early time-points (ie, days 1, 3, 7, 11, 14, and 21 after DSS exposure) indicates Ctnnb1/beta-catenin mutations and beta-catenin nuclear accumulation in the high-grade dysplastic lesions, but not low-grade dysplastic lesions or adjacent normal tissues.	dss	84-87	catenin (cadherin associated protein), beta 1	Mus musculus	108-114
27664423-8	2017	Overall, the findings suggest that PhIP/DSS-induced colon carcinogenesis is likely initiated by dominant active Ctnnb1/beta-catenin mutation in residual epithelial cells, which when promoted by colitis, developed into high-grade dysplasia and adenocarcinoma.	dss	40-43	catenin (cadherin associated protein), beta 1	Mus musculus	112-118
27664423-8	2017	Overall, the findings suggest that PhIP/DSS-induced colon carcinogenesis is likely initiated by dominant active Ctnnb1/beta-catenin mutation in residual epithelial cells, which when promoted by colitis, developed into high-grade dysplasia and adenocarcinoma.	dss	40-43	catenin (cadherin associated protein), beta 1	Mus musculus	119-131
28053542-6	2017	In addition, Cox multivariate analysis revealed that AZGP1 downregulation remained to be an independent prognosticator for shorter DSS (P=0.001), LRFS (P=0.011), and MeFS (P=0.004).	dss	131-134	alpha-2-glycoprotein 1, zinc-binding	Homo sapiens	53-58
27476063-3	2016	The aim of this study was to identify relationship between IL-6 -174G/C gene polymorphisms and clinical features, disease severity score (DSS) and proteinuria in children diagnosed with FMF.	dss	138-141	interleukin 6	Homo sapiens	59-63
28881743-8	2017	And the results also showed that high PODXL expression was obviously related to shorter DSS (HR=2.47, 95%CI=1.53-3.99, p=0.0002; I2=66%, p=0.03) and DFS (HR=2.12, 95%CI=1.58-2.85, p&lt;0.00001; I2=19%, p=0.29).	dss	88-91	podocalyxin like	Homo sapiens	38-43
28881743-9	2017	In conclusion, it was revealed that high PODXL expression is an unfavorable predictor of OS, DSS and DFS in patients with cancers, and high PODXL expression is a promising prognostic biomarker for cancers, especially for patients in European.	dss	93-96	podocalyxin like	Homo sapiens	41-46
27929086-7	2016	Furthermore, TRIM31 deficiency attenuates the severity of dextran sodium sulfate (DSS)-induced colitis, an inflammatory bowel diseases model in which NLRP3 possesses protective roles.	dss	82-85	tripartite motif containing 31	Homo sapiens	13-19
27929086-7	2016	Furthermore, TRIM31 deficiency attenuates the severity of dextran sodium sulfate (DSS)-induced colitis, an inflammatory bowel diseases model in which NLRP3 possesses protective roles.	dss	82-85	NLR family pyrin domain containing 3	Homo sapiens	150-155
27755216-0	2016	Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.	dss	87-90	serine protease 8	Rattus norvegicus	8-17
27000932-4	2016	DSS-induced decrease in liver and serum PON activities were completely recovered by prophylactic administration of curcumin.	dss	0-3	paraoxonase 1	Mus musculus	40-43
27755216-0	2016	Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.	dss	87-90	cyclase associated actin cytoskeleton regulatory protein 1	Rattus norvegicus	19-23
27755216-0	2016	Altered Prostasin (CAP1/Prss8) Expression Favors Inflammation and Tissue Remodeling in DSS-induced Colitis.	dss	87-90	serine protease 8	Rattus norvegicus	24-29
27755216-2	2016	We aimed to investigate whether mutated prostasin and thus, reduced colonic epithelial sodium channel activity predisposes to develop an experimentally dextran sodium sulfate (DSS)-induced colitis.	dss	176-179	serine protease 8	Rattus norvegicus	40-49
27166398-8	2016	Higher CD8+ T-cell density at the tumor periphery associated with improved DSS (P = 0.049).	dss	75-78	CD8a molecule	Homo sapiens	7-10
27832256-14	2016	Kaplan-Meier survival analysis showed that SCC of the upper and lower lip had similar overall survival (163.6 months vs 163.8 months) and DSS (418.6 months vs 423.6 months).	dss	138-141	serpin family B member 3	Homo sapiens	43-46
27832256-14	2016	Kaplan-Meier survival analysis showed that SCC of the upper and lower lip had similar overall survival (163.6 months vs 163.8 months) and DSS (418.6 months vs 423.6 months).	dss	138-141	SMG1 nonsense mediated mRNA decay associated PI3K related kinase	Homo sapiens	70-73
27832256-15	2016	In contrast, SCC of the oral commissure had significantly lower overall survival (128.5 months) and DSS (286.7 months).	dss	100-103	serpin family B member 3	Homo sapiens	13-16
27799307-5	2016	In this study, we show that CD1d-deficient mice, which lack all NKT cells, harbor an altered intestinal microbiota that is associated with exacerbated intestinal inflammation at steady-state and following DSS treatment.	dss	205-208	CD1d1 antigen	Mus musculus	28-32
27634763-7	2016	Fn14-/- mice had enhanced susceptibility to colitis compared with Fn14+/+ controls as assessed by endoscopic and histologic inflammatory scores, daily weight loss, and mortality rates during recovery after DSS administration.	dss	206-209	tumor necrosis factor receptor superfamily, member 12a	Mus musculus	0-4
27634763-10	2016	AOM/DSS administration enhanced susceptibility to tumorigenesis in Fn14-/- mice.	dss	4-7	tumor necrosis factor receptor superfamily, member 12a	Mus musculus	67-71
27764819-5	2016	RESULTS: Expression of CK19 in squamous cell carcinoma of the tongue was identified as a negative predictor for overall survival (OS; p&lt;0.000) and disease specific survival (DSS; p=0.001).	dss	177-180	keratin 19	Homo sapiens	23-27
27895918-13	2016	However, in the SCC group, samples showing loss of HLA-A or loss of total classical HLA but positive for HLA-G were linked to poor patient survival (DSS P = 0.001 and P = 0.01; DFS P = 0.003 and P = 0.01, for HLA-A and total classical HLA, respectively).	dss	149-152	serpin family B member 3	Homo sapiens	16-19
27780919-5	2016	Only a high expression level of MCM10 predicted worse disease-specific survival (DSS) and inferior metastasis-free survival (MeFS) for both UTUC and UBUC.	dss	81-84	minichromosome maintenance 10 replication initiation factor	Homo sapiens	32-37
27780919-8	2016	In multivariate Cox regression analyses, adjusted for standard clinicopathological features, MCM10 overexpression was independently associated with DSS (UTUC hazard ratio [HR]=2.401, P = 0.013; UBUC HR=4.323, P=0.001) and with MeFS (UTUC HR=3.294, P&lt;0.001; UBUC HR=1.972, P=0.015).	dss	148-151	minichromosome maintenance 10 replication initiation factor	Homo sapiens	93-98
27895918-13	2016	However, in the SCC group, samples showing loss of HLA-A or loss of total classical HLA but positive for HLA-G were linked to poor patient survival (DSS P = 0.001 and P = 0.01; DFS P = 0.003 and P = 0.01, for HLA-A and total classical HLA, respectively).	dss	149-152	major histocompatibility complex, class I, G	Homo sapiens	105-110
27747357-7	2016	In the DSS-induced colitis model and the LPS-stimulated RAW264.7 cell model, betaGs inhibited the expression of pro-inflammatory factors and blocked the phosphorylation of JNK/ERK1/2 and p38; betaGs also suppress the phosphorylation of Elk-1 at Ser84 and the phosphorylation of PPARgamma at Ser112.	dss	7-10	mitogen-activated protein kinase 8	Mus musculus	172-175
27846218-8	2016	In univariable analyses, positive MUC1 staining was significantly associated with a worse recurrence free survival (RFS) (HR: 1.24, CI 1.03-1.49, P = 0.02), although not with disease specific survival (DSS, P&gt;0.5).	dss	202-205	mucin 1, cell surface associated	Homo sapiens	34-38
27747357-0	2016	Oral administration of Lentinus edodes beta-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARgamma pathways.	dss	64-67	ELK1, member of ETS oncogene family	Mus musculus	112-117
27747357-0	2016	Oral administration of Lentinus edodes beta-glucans ameliorates DSS-induced ulcerative colitis in mice via MAPK-Elk-1 and MAPK-PPARgamma pathways.	dss	64-67	peroxisome proliferator activated receptor gamma	Mus musculus	127-136
27194531-6	2016	RESULTS: Compared with WT mice, TIMP-1 KO mice had higher inflammatory parameters after acute DSS administration and developed less fibrosis after chronic DSS administration.	dss	94-97	tissue inhibitor of metalloproteinase 1	Mus musculus	32-38
29441964-5	2016	A significant increase in IL-10 secretion and decrease in IL-12 production from LPS-stimulated macrophages were observed upon exposure to dextran sodium sulfate (DSS).	dss	162-165	interleukin 10	Mus musculus	26-31
29441964-6	2016	TNF-alpha production was enhanced significantly by exposure to DSS and LPS.	dss	63-66	tumor necrosis factor	Mus musculus	0-9
29441964-8	2016	Expression of sphingosine kinase-1 and LIGHT (both of which are specific biomarkers of M2b macrophages) was observed in macrophages upon DSS exposure.	dss	137-140	sphingosine kinase 1	Mus musculus	14-44
27194531-6	2016	RESULTS: Compared with WT mice, TIMP-1 KO mice had higher inflammatory parameters after acute DSS administration and developed less fibrosis after chronic DSS administration.	dss	155-158	tissue inhibitor of metalloproteinase 1	Mus musculus	32-38
27194531-9	2016	In response to DSS, the gene expression pattern was significantly different between young TIMP-1 KO and WT mice, whereas it was similar in older TIMP-1 KO and WT mice.	dss	15-18	tissue inhibitor of metalloproteinase 1	Mus musculus	90-96
27007678-2	2016	Here we show that, upon dextran sodium sulfate (DSS)-induced colitis, CD45-/- mice have equivalent intestinal pathology and T-cell numbers in their colon as C57BL/6 mice and show enhanced weight loss.	dss	48-51	protein tyrosine phosphatase, receptor type, C	Mus musculus	70-74
27007678-4	2016	In DSS-induced colitis in CD45RAG-/- mice lacking an adaptive immune system, CD45 was required for optimal granulocyte-macrophage colony-stimulating factor (GM-CSF) and retinoic acid (RA) production by innate immune cells.	dss	3-6	protein tyrosine phosphatase, receptor type, C	Mus musculus	26-30
27007678-4	2016	In DSS-induced colitis in CD45RAG-/- mice lacking an adaptive immune system, CD45 was required for optimal granulocyte-macrophage colony-stimulating factor (GM-CSF) and retinoic acid (RA) production by innate immune cells.	dss	3-6	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	107-155
27007678-4	2016	In DSS-induced colitis in CD45RAG-/- mice lacking an adaptive immune system, CD45 was required for optimal granulocyte-macrophage colony-stimulating factor (GM-CSF) and retinoic acid (RA) production by innate immune cells.	dss	3-6	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	157-163
27007678-5	2016	Addition of CD45+/+ T cells led to greater weight loss in the RAG-/- mice compared with CD45RAG-/- mice that correlated with reduced alpha4beta7+ T cells and lower recruitment to the colon of CD45RAG-/- mice in DSS-induced colitis.	dss	211-214	protein tyrosine phosphatase, receptor type, C	Mus musculus	12-16
27994654-11	2016	Low expression of RNF128 was an adverse prognosticator for DSS (UTUC, p&lt;0.0001; UBUC, p&lt;0.0001) and MeFS (UTUC, p&lt;0.0001; UBUC, p=0.0002).	dss	59-62	ring finger protein 128	Homo sapiens	18-24
27877005-13	2016	CONCLUSIONS: A CBC-based prognostic score model was revalidated to be accurate and superior to TNM stage on predicting 5-year DSS of NPC.	dss	126-129	teneurin transmembrane protein 1	Homo sapiens	95-98
27830030-8	2016	In addition, VNN1 overexpression was linked to adverse DSS, LRFS and MeFS in univariate analysis and served as an independent prognosticator indicating worse DSS and LRFS in multivariate analysis (all P &lt;= .019).	dss	55-58	vanin 1	Homo sapiens	13-17
27830030-8	2016	In addition, VNN1 overexpression was linked to adverse DSS, LRFS and MeFS in univariate analysis and served as an independent prognosticator indicating worse DSS and LRFS in multivariate analysis (all P &lt;= .019).	dss	158-161	vanin 1	Homo sapiens	13-17
27556502-4	2016	Survival analyses indicated that patients with higher CHKA expression had a significantly shorter disease-free survival (DFS) and disease-specific survival (DSS) than those with lower CHKA expression.	dss	157-160	choline kinase alpha	Homo sapiens	54-58
27729740-13	2016	Expression of Myc and Ccl5 was increased by DSS treatment in Winnie only.	dss	44-47	myelocytomatosis oncogene	Mus musculus	14-17
27729740-13	2016	Expression of Myc and Ccl5 was increased by DSS treatment in Winnie only.	dss	44-47	chemokine (C-C motif) ligand 5	Mus musculus	22-26
27605405-12	2016	The DSS+10% GG and PHGG groups showed ~110%, 60%, 120%, and 110% greater (P &lt; 0.05) expression of occludin and claudin 3, 4, and 7, respectively, in the colon than did the DSS group.	dss	4-7	occludin	Mus musculus	101-109
27605405-12	2016	The DSS+10% GG and PHGG groups showed ~110%, 60%, 120%, and 110% greater (P &lt; 0.05) expression of occludin and claudin 3, 4, and 7, respectively, in the colon than did the DSS group.	dss	4-7	claudin 3	Mus musculus	114-123
27605405-12	2016	The DSS+10% GG and PHGG groups showed ~110%, 60%, 120%, and 110% greater (P &lt; 0.05) expression of occludin and claudin 3, 4, and 7, respectively, in the colon than did the DSS group.	dss	175-178	occludin	Mus musculus	101-109
27643881-6	2016	The expression of PARP1, gammaH2AX, and BRCA2 were significantly associated with shorter disease-specific survival (DSS) and event-free survival (EFS) by univariate analysis.	dss	116-119	poly(ADP-ribose) polymerase 1	Homo sapiens	18-23
27658624-7	2016	Some of the protective effects of MOS were likely be mediated directly through local macrophages because MOS dose-dependently inhibited IL-1b and G-CSF induction following in vitro DSS challenge and IL1a, IL1b, G-SCF-, and IL6 increases after LPS treatment in mouse macrophage cell line RAW264.7.	dss	181-184	interleukin 1 beta	Mus musculus	136-141
27658624-7	2016	Some of the protective effects of MOS were likely be mediated directly through local macrophages because MOS dose-dependently inhibited IL-1b and G-CSF induction following in vitro DSS challenge and IL1a, IL1b, G-SCF-, and IL6 increases after LPS treatment in mouse macrophage cell line RAW264.7.	dss	181-184	colony stimulating factor 3 (granulocyte)	Mus musculus	146-151
27643881-6	2016	The expression of PARP1, gammaH2AX, and BRCA2 were significantly associated with shorter disease-specific survival (DSS) and event-free survival (EFS) by univariate analysis.	dss	116-119	BRCA2 DNA repair associated	Homo sapiens	40-45
27643881-7	2016	BRCA1 expression was associated with shorter DSS.	dss	45-48	BRCA1 DNA repair associated	Homo sapiens	0-5
27643881-8	2016	Multivariate analysis revealed the expression of PARP1 and gammaH2AX to be independent indicators of poor prognosis of DSS and EFS.	dss	119-122	poly(ADP-ribose) polymerase 1	Homo sapiens	49-54
27643881-9	2016	BRCA2 expression was an independent indicator of poor prognosis of DSS.	dss	67-70	BRCA2 DNA repair associated	Homo sapiens	0-5
27643881-10	2016	In addition, the combined expressional patterns of PARP1, gammaH2AX, BRCA1, and BRCA2 (CSddrm) were independent prognostic predictors of DSS (P &lt; 0.001) and EFS (P = 0.016).	dss	137-140	poly(ADP-ribose) polymerase 1	Homo sapiens	51-56
27643881-10	2016	In addition, the combined expressional patterns of PARP1, gammaH2AX, BRCA1, and BRCA2 (CSddrm) were independent prognostic predictors of DSS (P &lt; 0.001) and EFS (P = 0.016).	dss	137-140	BRCA1 DNA repair associated	Homo sapiens	69-74
27643881-10	2016	In addition, the combined expressional patterns of PARP1, gammaH2AX, BRCA1, and BRCA2 (CSddrm) were independent prognostic predictors of DSS (P &lt; 0.001) and EFS (P = 0.016).	dss	137-140	BRCA2 DNA repair associated	Homo sapiens	80-85
27626448-5	2016	Dextran sulphate sodium (DSS)-colitis was used as a model for intestinal inflammatory stress, which elicited a strong upregulation and widened crypt distribution of K7 and K20.	dss	25-28	keratin 20	Homo sapiens	172-175
27450811-5	2016	Here we show that Dok-1/-2 double knockout (DKO) mice were highly susceptible to dextran sodium sulfate (DSS)-induced colitis compared with Dok-1 or Dok-2 single KO and wild type (WT) mice.	dss	105-108	docking protein 1	Mus musculus	18-23
27450811-6	2016	Furthermore, DSS-treated Dok-1/-2 DKO mice exhibited increased colonic tissue damage accompanied by reduced proliferation of the epithelial cells relative to WT controls, suggesting that Dok-1/-2 DKO mice have defects in the repair of intestinal epithelial lesions.	dss	13-16	docking protein 1	Mus musculus	25-30
27450811-6	2016	Furthermore, DSS-treated Dok-1/-2 DKO mice exhibited increased colonic tissue damage accompanied by reduced proliferation of the epithelial cells relative to WT controls, suggesting that Dok-1/-2 DKO mice have defects in the repair of intestinal epithelial lesions.	dss	13-16	docking protein 1	Mus musculus	187-192
27450811-7	2016	In addition, the levels of the Th17 cytokines IL-17A and IL-22, which have protective roles in DSS-induced colitis, were reduced in DSS-treated Dok-1/-2 DKO mice compared with WT mice.	dss	95-98	interleukin 17A	Mus musculus	46-52
27630332-9	2016	BRAF mutant status was a strong independent predictor of both worse OS/DSS and RFS in 7 and 4 studies, respectively.	dss	71-74	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
27450811-7	2016	In addition, the levels of the Th17 cytokines IL-17A and IL-22, which have protective roles in DSS-induced colitis, were reduced in DSS-treated Dok-1/-2 DKO mice compared with WT mice.	dss	95-98	interleukin 22	Mus musculus	57-62
27450811-7	2016	In addition, the levels of the Th17 cytokines IL-17A and IL-22, which have protective roles in DSS-induced colitis, were reduced in DSS-treated Dok-1/-2 DKO mice compared with WT mice.	dss	95-98	docking protein 1	Mus musculus	144-149
27450811-7	2016	In addition, the levels of the Th17 cytokines IL-17A and IL-22, which have protective roles in DSS-induced colitis, were reduced in DSS-treated Dok-1/-2 DKO mice compared with WT mice.	dss	132-135	interleukin 17A	Mus musculus	46-52
27450811-7	2016	In addition, the levels of the Th17 cytokines IL-17A and IL-22, which have protective roles in DSS-induced colitis, were reduced in DSS-treated Dok-1/-2 DKO mice compared with WT mice.	dss	132-135	interleukin 22	Mus musculus	57-62
27450811-7	2016	In addition, the levels of the Th17 cytokines IL-17A and IL-22, which have protective roles in DSS-induced colitis, were reduced in DSS-treated Dok-1/-2 DKO mice compared with WT mice.	dss	132-135	docking protein 1	Mus musculus	144-149
27627702-5	2016	As a result, the CPAE counteracted DSS-induced increase of MPO activity, lipoperoxidation, and the activity of antioxidant enzymes, such as superoxide dismutase and catalase (CAT).	dss	35-38	myeloperoxidase	Rattus norvegicus	59-62
27721874-10	2016	BCL2-positive expression was also associated with favorable 5-year RFS (p=0.008, 91.4%) and DSS (p=0.036, 95.6%) in all the patients.	dss	92-95	BCL2 apoptosis regulator	Homo sapiens	0-4
27721874-11	2016	BCL2-positive expression in luminal A breast cancer resulted in significantly favorable 5-year RFS and DSS (p=0.023 and p=0.041, respectively).	dss	103-106	BCL2 apoptosis regulator	Homo sapiens	0-4
27425846-8	2016	Increased susceptibility to DSS-induced inflammation was noted in apoA-I(-/-) mice.	dss	28-31	apolipoprotein A-I	Mus musculus	66-72
27627702-5	2016	As a result, the CPAE counteracted DSS-induced increase of MPO activity, lipoperoxidation, and the activity of antioxidant enzymes, such as superoxide dismutase and catalase (CAT).	dss	35-38	catalase	Rattus norvegicus	165-173
27627702-5	2016	As a result, the CPAE counteracted DSS-induced increase of MPO activity, lipoperoxidation, and the activity of antioxidant enzymes, such as superoxide dismutase and catalase (CAT).	dss	35-38	catalase	Rattus norvegicus	175-178
27428018-7	2016	In contrast, the beta-endorphin level in the blood of the UVA/DSS-treated mice increased and the levels of urocortin 2, tumor necrosis factor (TNF)-alpha and histamine decreased.	dss	62-65	pro-opiomelanocortin-alpha	Mus musculus	17-31
27539446-11	2016	VEGF and TNF-alpha concentrations in pulmonary tissues were significantly increased in both the TNBS colitis and DSS colitis groups compared to their own control groups (p = 0.002 and p = 0.004, respectively; and p = 0.002 and p = 0.002, respectively).	dss	113-116	vascular endothelial growth factor A	Rattus norvegicus	0-4
27539446-11	2016	VEGF and TNF-alpha concentrations in pulmonary tissues were significantly increased in both the TNBS colitis and DSS colitis groups compared to their own control groups (p = 0.002 and p = 0.004, respectively; and p = 0.002 and p = 0.002, respectively).	dss	113-116	tumor necrosis factor	Rattus norvegicus	9-18
27428018-8	2016	Furthermore, in the colon, the expression of melanocortin-2 receptors (MC2R) increased in the UVB/DSS-treated mice, while the expression of mu-opioid receptors increased in the UVA/DSS-treated mice.	dss	98-101	melanocortin 2 receptor	Mus musculus	45-69
27428018-8	2016	Furthermore, in the colon, the expression of melanocortin-2 receptors (MC2R) increased in the UVB/DSS-treated mice, while the expression of mu-opioid receptors increased in the UVA/DSS-treated mice.	dss	98-101	melanocortin 2 receptor	Mus musculus	71-75
27428018-9	2016	When an ACTH inhibitor was administered, UVB eye irradiation caused the deterioration of DSS-treated ulcerative colitis, while the effect of UV eye irradiation disappeared with a mu-opioid receptor antagonist.	dss	89-92	pro-opiomelanocortin-alpha	Mus musculus	8-12
27165976-6	2016	MUC1 status was correlated with various tumor features and biochemical recurrence-free (bRFS), disease-specific survival (DSS) and overall survival (OS).	dss	122-125	mucin 1, cell surface associated	Homo sapiens	0-4
27377730-3	2016	Moreover, ZnR/GPR39 is essential for epithelial barrier recovery in the dextran sodium sulfate (DSS) ulcerative colitis model.	dss	96-99	G protein-coupled receptor 39	Mus musculus	14-19
27506357-4	2016	DSS samples were prepared by spotting 15 muL of liquid saliva onto regular Whatman FTA  DMPK-C cards and verified with a UV lamp (at lambda 254 nm or 365 nm) during DSS punching.	dss	0-3	DM1 protein kinase	Homo sapiens	88-92
27602128-11	2016	Univariate Cox regression analysis showed that overexpression of c-met was associated neither with progression-free survival (PFS) nor with disease-specific survival (DSS) (P=0.835 and P=0.414, respectively).	dss	167-170	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	65-70
28174748-15	2016	Wnt/beta-catenin signaling was reduced significantly in the crypt base in Galphaq/G11-deficient mice, resulting in the defective maturation of Paneth cells, induction of differentiation toward goblet cells, and susceptibility to DSS colitis.	dss	229-232	catenin (cadherin associated protein), beta 1	Mus musculus	4-16
28174748-15	2016	Wnt/beta-catenin signaling was reduced significantly in the crypt base in Galphaq/G11-deficient mice, resulting in the defective maturation of Paneth cells, induction of differentiation toward goblet cells, and susceptibility to DSS colitis.	dss	229-232	guanine nucleotide binding protein, alpha q polypeptide	Mus musculus	74-81
27538787-6	2016	Offspring of F0(DSS) males exhibited aberrant methylation and expression patterns of multiple genes, including Igf1r and Nr4a2, which are involved in energy metabolism.	dss	16-19	insulin-like growth factor I receptor	Mus musculus	111-116
27538787-6	2016	Offspring of F0(DSS) males exhibited aberrant methylation and expression patterns of multiple genes, including Igf1r and Nr4a2, which are involved in energy metabolism.	dss	16-19	nuclear receptor subfamily 4, group A, member 2	Mus musculus	121-126
27377730-9	2016	Our results support a direct role for ZnR/GPR39 in promoting epithelial renewal and barrier function following DSS treatment, thereby affecting the severity of the disease.	dss	111-114	G protein-coupled receptor 39	Mus musculus	42-47
27377730-4	2016	Loss of ZnR/GPR39 results in increased susceptibility to DSS-induced inflammation, owing to low expression of the tight junction protein occludin and impaired epithelial barrier.	dss	57-60	G protein-coupled receptor 39	Mus musculus	12-17
27377730-4	2016	Loss of ZnR/GPR39 results in increased susceptibility to DSS-induced inflammation, owing to low expression of the tight junction protein occludin and impaired epithelial barrier.	dss	57-60	occludin	Mus musculus	137-145
27377730-6	2016	Enhanced recovery of the epithelial layer and increased crypt regeneration were observed in WT mice compared with ZnR/GPR39 KO, suggesting that ZnR/GPR39 is promoting epithelial barrier integrity following DSS insult.	dss	206-209	G protein-coupled receptor 39	Mus musculus	148-153
27377730-7	2016	Indeed, cell proliferation and apical expression of occludin, following the DSS-induced epithelial erosion, were increased in WT tissue but not in ZnR/GPR39 KO tissue.	dss	76-79	occludin	Mus musculus	52-60
27536732-5	2016	In the dextran sodium sulfate (DSS) colitis model, 2-PMPA inhibited the GCPII activity in the colonic mucosa by over 90% and substantially reduced the disease activity.	dss	31-34	folate hydrolase 1	Homo sapiens	72-77
27536732-6	2016	The significance of the target was confirmed in FOLH1-/- mice who exhibited resistance to DSS treatment.	dss	90-93	folate hydrolase 1	Mus musculus	48-53
27096537-6	2016	The inflammation markers MPO, IL-1beta, IL-6 and mKC (mouse keratinocyte chemoattractant) were increased by DSS and significantly reduced by the L. reuteri strains.	dss	108-111	myeloperoxidase	Mus musculus	25-28
26573952-6	2016	Moreover, the influence of CRP and SCC-Ag levels on DSS (P = 0.033, hazard ratio 3.390, 95% confidence interval 1.104-10.411) remained after adjusting for smoking history, phimosis, tumour status, tumour cell differentiation and nodal status.	dss	52-55	C-reactive protein	Homo sapiens	27-30
26573952-7	2016	CONCLUSIONS: The present study shows that the combined measurement of preoperative CRP and SCC-Ag levels may serve as an independent biomarker for LNM, advanced tumour stage and DSS in patients with penile SCC.	dss	178-181	C-reactive protein	Homo sapiens	83-86
27096537-6	2016	The inflammation markers MPO, IL-1beta, IL-6 and mKC (mouse keratinocyte chemoattractant) were increased by DSS and significantly reduced by the L. reuteri strains.	dss	108-111	interleukin 6	Mus musculus	40-44
27130484-3	2016	Deletion of Sgpp2, which is mainly expressed in the gastrointestinal tract, significantly reduced dextran sodium sulfate (DSS)-induced colitis severity, whereas deletion of ubiquitously expressed Sgpp1 slightly worsened colitis.	dss	122-125	sphingosine-1-phosphate phosphatase 2	Mus musculus	12-17
26991344-4	2016	KRAS and BRAF mutations also predicted a reduced median disease-specific survival (DSS) (29 vs. 51 and 16 vs. 49 months; p &lt;0.001 and 0.008, respectively).	dss	83-86	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
26991344-4	2016	KRAS and BRAF mutations also predicted a reduced median disease-specific survival (DSS) (29 vs. 51 and 16 vs. 49 months; p &lt;0.001 and 0.008, respectively).	dss	83-86	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	9-13
26991344-9	2016	In multivariate analyses, KRAS or BRAF mutations consistently predicted poor TRR and DSS.	dss	85-88	KRAS proto-oncogene, GTPase	Homo sapiens	26-30
26991344-9	2016	In multivariate analyses, KRAS or BRAF mutations consistently predicted poor TRR and DSS.	dss	85-88	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	34-38
27130484-6	2016	Of interest, Sgpp2 deficiency suppressed DSS-induced intestinal epithelial cell apoptosis and improved mucosal barrier integrity.	dss	41-44	sphingosine-1-phosphate phosphatase 2	Mus musculus	13-18
27471570-7	2016	Moreover, statistical analyses were performed to correlate the association between THBS2 expression and clinicopathological parameters with two survival indexes: disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	189-192	thrombospondin 2	Homo sapiens	83-88
27283772-3	2016	Here, we demonstrate that the carriage of missense mutations in the TP53 DNA binding domain (DBD missense mutations) is associated with decreased disease-specific survival (DSS) compared with wild-type TP53 (P=0.002) in a cohort of 345 OSCC patients.	dss	173-176	tumor protein p53	Homo sapiens	68-72
27283772-6	2016	When analyzed in combination with traditional clinicopathological factors, TP53 DBD missense mutations were an independent prognostic factor for shorter DSS (P=0.014) alongside with advanced AJCC T- and N-classifications and the presence of extracapsular spread.	dss	153-156	tumor protein p53	Homo sapiens	75-79
27698909-8	2016	Results: GAD1 overexpression was significantly associated with an increase in the primary tumor status (p &lt; 0.001) and American Joint Committee on Cancer (AJCC) stages III-IV (p = 0.002) and was a univariate predictor of adverse outcomes of DSS (p = 0.002), DMeFS (p &lt; 0.0001), and LRFS (p = 0.001).	dss	244-247	glutamate decarboxylase 1	Homo sapiens	9-13
27698909-9	2016	In the multivariate comparison, in addition to advanced AJCC stages III-IV, GAD1 overexpression remained an independent prognosticator of short DSS (p = 0.004, hazard ratio = 2.234), DMeFS (p &lt; 0.001, hazard ratio = 4.218), and LRFS (p = 0.013, hazard ratio = 2.441) rates.	dss	144-147	glutamate decarboxylase 1	Homo sapiens	76-80
27500193-4	2016	Neutralization of Lcn2 in WT mice resulted in exacerbated DSS-induced colitis.	dss	58-61	lipocalin 2	Mus musculus	18-22
26957503-8	2016	Five-year DSS was 87 % for a 1 cm margin and 85 % for a 2 cm margin (p = not significant).	dss	10-13	BCL2 related protein A1	Homo sapiens	27-30
27471570-9	2016	In addition, THBS2 overexpression was linked to adverse DSS and MeFS in univariate analyses and served as an independent prognosticator indicating poor outcomes in both groups in multivariate analyses.	dss	56-59	thrombospondin 2	Homo sapiens	13-18
26614788-8	2016	High PAK4 expression was significantly associated with poorer disease-specific survival (DSS) (p&lt;0.001) and relapse-free survival (RFS) (p&lt;0.001).	dss	89-92	p21 (RAC1) activated kinase 4	Homo sapiens	5-9
27297724-8	2016	Multivariate analysis revealed that the status of maspin was the only independent prognostic factor for DFS and DSS (P = 0.017, P = 0.047, respectively).	dss	112-115	serpin family B member 5	Homo sapiens	50-56
27138790-9	2016	Inhibition of GSK-3beta and loss of nuclear NF-kappaB activity were also observed in vivo in AOM/DSS-treated mice fed a diet supplemented with 85 ppm DADS.	dss	97-100	glycogen synthase kinase 3 beta	Mus musculus	14-23
26879675-6	2016	After controlling for prognostic factors, higher CD4 levels predicted improved OS and disease-specific survival (DSS; p = .003 and p = .004, respectively).	dss	113-116	CD4 molecule	Homo sapiens	49-52
26614788-9	2016	On multivariable analysis, PAK4 was an independent prognostic factor for DSS (HR 2.5 (95% CI 1.4 to 4.7), p=0.003) and RFS (HR 2.8 (95% CI 1.4 to 5.6), p=0.004).	dss	73-76	p21 (RAC1) activated kinase 4	Homo sapiens	27-31
26980915-10	2016	Patients positive for cMet (P = .007), cyclin D1 (P = .019), and p16 (P = .004) had worse DSS.	dss	90-93	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	22-26
26888626-8	2016	Three-year disease specific survival (DSS) was significantly lower (p = 0.007) at 63.2% for patients who showed &lt;12% increase in CD3zeta-chain level as compared to 96.2% for patients who had &gt;=12% increase.	dss	38-41	CD247 molecule	Homo sapiens	132-145
27196434-13	2016	Adverse predictors of DSS were p16-negative status (HR, 16.8; 95% CI, 3.9-71.2) and ECS (HR, 8.3; 95% CI, 2.0-35.3).	dss	22-25	cyclin dependent kinase inhibitor 2A	Homo sapiens	31-34
27196434-14	2016	Among p16-negative patients, ECS was significantly associated with worse RFS (HR, 9.7; 95% CI, 1.3-72.3) and DSS (HR, 8.7; 95% CI, 1.1-62.7).	dss	109-112	cyclin dependent kinase inhibitor 2A	Homo sapiens	6-9
26818658-9	2016	We investigated MIR429 that is down-regulated in DSS-induced colitis, and identified 41 target genes of MIR429.	dss	49-52	microRNA 429	Mus musculus	16-22
26818658-11	2016	MARCKS mRNA and protein expression levels are down-regulated by MIR429, and MIR429 regulates the expression of MARCKS and MARCKS-mediated mucin secretion in colorectal cells and DSS-induced colitis.	dss	178-181	myristoylated alanine rich protein kinase C substrate	Mus musculus	0-6
26818658-11	2016	MARCKS mRNA and protein expression levels are down-regulated by MIR429, and MIR429 regulates the expression of MARCKS and MARCKS-mediated mucin secretion in colorectal cells and DSS-induced colitis.	dss	178-181	microRNA 429	Mus musculus	64-70
26818658-11	2016	MARCKS mRNA and protein expression levels are down-regulated by MIR429, and MIR429 regulates the expression of MARCKS and MARCKS-mediated mucin secretion in colorectal cells and DSS-induced colitis.	dss	178-181	microRNA 429	Mus musculus	76-82
26818658-11	2016	MARCKS mRNA and protein expression levels are down-regulated by MIR429, and MIR429 regulates the expression of MARCKS and MARCKS-mediated mucin secretion in colorectal cells and DSS-induced colitis.	dss	178-181	myristoylated alanine rich protein kinase C substrate	Mus musculus	111-117
26818658-11	2016	MARCKS mRNA and protein expression levels are down-regulated by MIR429, and MIR429 regulates the expression of MARCKS and MARCKS-mediated mucin secretion in colorectal cells and DSS-induced colitis.	dss	178-181	myristoylated alanine rich protein kinase C substrate	Mus musculus	111-117
26818658-11	2016	MARCKS mRNA and protein expression levels are down-regulated by MIR429, and MIR429 regulates the expression of MARCKS and MARCKS-mediated mucin secretion in colorectal cells and DSS-induced colitis.	dss	178-181	LOC100508689	Homo sapiens	138-143
26980915-10	2016	Patients positive for cMet (P = .007), cyclin D1 (P = .019), and p16 (P = .004) had worse DSS.	dss	90-93	cyclin D1	Homo sapiens	39-48
26980915-10	2016	Patients positive for cMet (P = .007), cyclin D1 (P = .019), and p16 (P = .004) had worse DSS.	dss	90-93	cyclin dependent kinase inhibitor 2A	Homo sapiens	65-68
26980915-13	2016	CONCLUSION: cMet, cyclin D1, and p16 are predictive tumor biomarkers for risk of recurrence and worse DSS in patients with SpSCC.	dss	102-105	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	12-16
26980915-13	2016	CONCLUSION: cMet, cyclin D1, and p16 are predictive tumor biomarkers for risk of recurrence and worse DSS in patients with SpSCC.	dss	102-105	cyclin dependent kinase inhibitor 2A	Homo sapiens	33-36
27007712-6	2016	Herein, we also show a negative association between serum Lcn2 and CI in the murine model of dextran sodium sulfate (DSS)-induced colitis.	dss	117-120	lipocalin 2	Mus musculus	58-62
27209086-7	2016	Finally, lamina propria dendritic cells (LPDCs) from the colon of MD-1(-/-) mice after DSS exposure not only decreased in number but also significantly down-regulated the expression of surface maturation co-stimulatory molecules MHC-II, CD40 and CD86 compared with those from WT mice.	dss	87-90	histocompatibility-2, MHC	Mus musculus	229-235
27209086-7	2016	Finally, lamina propria dendritic cells (LPDCs) from the colon of MD-1(-/-) mice after DSS exposure not only decreased in number but also significantly down-regulated the expression of surface maturation co-stimulatory molecules MHC-II, CD40 and CD86 compared with those from WT mice.	dss	87-90	CD40 antigen	Mus musculus	237-241
27209086-7	2016	Finally, lamina propria dendritic cells (LPDCs) from the colon of MD-1(-/-) mice after DSS exposure not only decreased in number but also significantly down-regulated the expression of surface maturation co-stimulatory molecules MHC-II, CD40 and CD86 compared with those from WT mice.	dss	87-90	CD86 antigen	Mus musculus	246-250
26990520-7	2016	DSS increased the number of colonic nerve fibres that were double positive for 5-HT3 receptors and SP but not of those that were double positive for 5-HT3 receptors and vesicular ACh transporter.	dss	0-3	tachykinin 1	Mus musculus	99-101
26990520-8	2016	DSS increased colonic SP levels and SP-positive nerve fibres; these responses were attenuated by ramosetron.	dss	0-3	tachykinin 1	Mus musculus	22-24
26990520-8	2016	DSS increased colonic SP levels and SP-positive nerve fibres; these responses were attenuated by ramosetron.	dss	0-3	tachykinin 1	Mus musculus	36-38
26990520-9	2016	DSS-induced colitis and up-regulation of inflammatory mediators were attenuated by aprepitant, an NK1 antagonist.	dss	0-3	tachykinin 1	Mus musculus	98-101
26990520-10	2016	Immunohistochemical studies further revealed that DSS treatment markedly increased NK1 receptor expression in CD11b-positive cells.	dss	50-53	tachykinin receptor 1	Homo sapiens	83-95
26990520-10	2016	Immunohistochemical studies further revealed that DSS treatment markedly increased NK1 receptor expression in CD11b-positive cells.	dss	50-53	integrin subunit alpha M	Homo sapiens	110-115
27208127-5	2016	It is further demonstrated that intestinal lipids and CL are less effective at neutralizing more potent Enterobacteriaceae-type LPS, which is enriched in feces obtained from mice with dextran sodium sulfate (DSS)-treated inflammatory bowel disease.	dss	208-211	toll-like receptor 4	Mus musculus	128-131
27016409-6	2016	The multivariate analysis identified that patient"s age at diagnosis, race, tumor location, grade, depth of invasion, metastatic lymph node stage (mLNS) and total number of examined lymph node (TLN) were associated with patient"s DSS.	dss	230-233	intercellular adhesion molecule 5	Homo sapiens	194-197
27280399-2	2016	Here we found that mice deficient in Dectin-3 (Clec4d-/-), a C-type lectin receptor that senses fungal infection, were more susceptible to dextran sodium sulfate (DSS)-induced colitis compared with wild-type mice.	dss	163-166	C-type lectin domain family 4, member d	Mus musculus	47-53
26925602-6	2016	Furthermore, K65 inhibited TNF-alpha, cyclo-oxygenase 2, forkhead box P3, and Toll-like receptor 4 mRNA expression in the colonic tissue of DSS-induced UC mice.	dss	140-143	toll-like receptor 4	Mus musculus	78-98
25761602-0	2016	TLR-independent anti-inflammatory function of intestinal epithelial TRAF6 signalling prevents DSS-induced colitis in mice.	dss	94-97	TNF receptor-associated factor 6	Mus musculus	68-73
26459250-10	2016	High expression of TrkA or TrkC was significantly associated with poorer disease-specific survival (DSS) in univariate analysis (p &lt; 0.001 and p = 0.008).	dss	100-103	neurotrophic receptor tyrosine kinase 1	Homo sapiens	19-23
26459250-10	2016	High expression of TrkA or TrkC was significantly associated with poorer disease-specific survival (DSS) in univariate analysis (p &lt; 0.001 and p = 0.008).	dss	100-103	neurotrophic receptor tyrosine kinase 3	Homo sapiens	27-31
25761602-4	2016	RESULTS: Mice lacking TRAF6 in IECs showed exacerbated DSS-induced inflammatory responses that ensued in the development of chronic colon inflammation.	dss	55-58	TNF receptor-associated factor 6	Mus musculus	22-27
25761602-5	2016	Antibiotic pretreatment abolished the increased DSS susceptibility of these mice, showing that epithelial TRAF6 signalling pathways prevent the gut microbiota from driving excessive colitis.	dss	48-51	TNF receptor-associated factor 6	Mus musculus	106-111
26950306-4	2016	In the present study, we found that Wip1 knockout (KO) mice were more susceptible to colitis induced by dextran sulphate sodium (DSS) than wild-type mice as substantiated by the lower mouse survival ratio, rapid bodyweight loss, increased disease activity index, shorter colon length, and more severe pathology of colons in Wip1KO mice.	dss	129-132	protein phosphatase 1D magnesium-dependent, delta isoform	Mus musculus	36-40
25761602-8	2016	CONCLUSIONS: Intestinal epithelial TRAF6-dependent but MyD88/TRIF-independent and, thus, TLR-independent signalling pathways are critical for preventing propagation of DSS-induced colon inflammation by the gut microbiota.	dss	168-171	TNF receptor-associated factor 6	Mus musculus	35-40
26950306-7	2016	Neutrophils of DSS-treated wild-type and Wip1KO mice expressed significantly higher IL-17.	dss	15-18	interleukin 17A	Mus musculus	84-89
25761602-8	2016	CONCLUSIONS: Intestinal epithelial TRAF6-dependent but MyD88/TRIF-independent and, thus, TLR-independent signalling pathways are critical for preventing propagation of DSS-induced colon inflammation by the gut microbiota.	dss	168-171	myeloid differentiation primary response gene 88	Mus musculus	55-60
25761602-8	2016	CONCLUSIONS: Intestinal epithelial TRAF6-dependent but MyD88/TRIF-independent and, thus, TLR-independent signalling pathways are critical for preventing propagation of DSS-induced colon inflammation by the gut microbiota.	dss	168-171	toll-like receptor adaptor molecule 1	Mus musculus	61-65
27215610-5	2016	Our study clearly demonstrated that CPUY192018 had a cytoprotective effect against DSS in both NCM460 cells and mouse colon via the activation of Nrf2 signaling.	dss	83-86	nuclear factor, erythroid derived 2, like 2	Mus musculus	146-150
26969166-6	2016	The SIRT1 agonist SRT1720 was used to enhance PGC1alpha activation in wild-type mice during DSS exposure.	dss	92-95	sirtuin 1	Mus musculus	4-9
27326252-9	2016	High PSAT1 expression also correlated with an aggressive clinical course, with significantly shorter DSS (HR= 2.856, 95% CI 1.599 to 5.101), DMFS (HR= 3.305, 95% CI 1.720 to 6.347), LRFS (HR= 2.834, 95% CI 1.376 to 5.835), and OS HR= 2.935, 95% CI 1.646-5.234) in multivariate analyses.	dss	101-104	phosphoserine aminotransferase 1	Homo sapiens	5-10
26364605-6	2016	Muc4(-/-) mice displayed increased resistance to DSS-induced colitis compared with wild-type (WT) littermates that was evaluated by survival rate, body weight loss, diarrhea and fecal blood score, and histological score.	dss	49-52	mucin 4	Mus musculus	0-4
26364605-8	2016	Compensatory upregulation of Muc2 and Muc3 mucins under basal and DSS treatment conditions partly explains the resistance observed in Muc4(-/-) mice.	dss	66-69	mucin 2	Mus musculus	29-33
26364605-8	2016	Compensatory upregulation of Muc2 and Muc3 mucins under basal and DSS treatment conditions partly explains the resistance observed in Muc4(-/-) mice.	dss	66-69	mucin 3, intestinal	Mus musculus	38-42
26364605-8	2016	Compensatory upregulation of Muc2 and Muc3 mucins under basal and DSS treatment conditions partly explains the resistance observed in Muc4(-/-) mice.	dss	66-69	mucin 4	Mus musculus	134-138
26364605-9	2016	Accordingly, Muc4(-/-) mice exhibited significantly reduced tumor burden compared with WT mice assessed in a colitis-induced tumor model using AOM/DSS.	dss	147-150	mucin 4	Mus musculus	13-17
26671993-9	2016	In the JBR.10 trial, improved 5-year DSS was noted only in patients with low SMARCA4 expression when treated with adjuvant cisplatin/vinorelbine [HR, 0.1; 95% CI, 0.0-0.5, P = 0.002 (low); HR, 1.0; 95% CI, 0.5-2.3, P = 0.92 (high)].	dss	37-40	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Homo sapiens	77-84
26969166-6	2016	The SIRT1 agonist SRT1720 was used to enhance PGC1alpha activation in wild-type mice during DSS exposure.	dss	92-95	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	46-55
26969166-7	2016	Mice lacking PGC1alpha within the intestinal epithelium were more susceptible to DSS colitis than their wild-type littermates.	dss	81-84	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	13-22
26479868-2	2016	We recently demonstrated that beta-arrestin1 (beta-arr1) deficiency strikingly attenuates dextran sodium sulfate (DSS)-induced colitis in mice.	dss	114-117	arrestin, beta 1	Mus musculus	30-44
27186569-7	2016	According to mSE findings (+/-), the 5-year disease-specific survival (DSS) rate differed significantly in patients with pT2 (+; 74.2% vs. -; 92.0%), pT3 (+; 76.7% vs. -; 91.8%) and pT4a (+; 51.3% vs. -; 72.8%) (P &lt; 0.001 each), but not in patients with T1 tumor.	dss	71-74	enolase 3, beta muscle	Mus musculus	13-16
27186569-7	2016	According to mSE findings (+/-), the 5-year disease-specific survival (DSS) rate differed significantly in patients with pT2 (+; 74.2% vs. -; 92.0%), pT3 (+; 76.7% vs. -; 91.8%) and pT4a (+; 51.3% vs. -; 72.8%) (P &lt; 0.001 each), but not in patients with T1 tumor.	dss	71-74	zinc finger protein 135	Homo sapiens	150-153
25673319-9	2016	The severity of DSS-induced colitis was assessed in mice given either an Fc fusion protein containing an extracellular domain of LMIR3, and anticeramide antibody, or ceramide liposomes.	dss	16-19	CD300 molecule like family member F	Mus musculus	129-134
25673319-10	2016	RESULTS: LMIR3 deficiency exacerbated DSS-induced colitis in mice.	dss	38-41	CD300 molecule like family member F	Mus musculus	9-14
25673319-13	2016	DSS-induced colitis was aggravated by disrupting the ceramide-LMIR3 interaction, whereas it was suppressed by treating with ceramide liposomes.	dss	0-3	CD300 molecule like family member F	Mus musculus	62-67
25673319-14	2016	CONCLUSIONS: LMIR3-deficient colonic mast cells were pivotal in the exacerbation of DSS-induced colitis in LMIR3(-/-) mice.	dss	84-87	CD300 molecule like family member F	Mus musculus	13-18
25673319-14	2016	CONCLUSIONS: LMIR3-deficient colonic mast cells were pivotal in the exacerbation of DSS-induced colitis in LMIR3(-/-) mice.	dss	84-87	CD300 molecule like family member F	Mus musculus	107-112
25673319-15	2016	Ceramide liposomes attenuated DSS-induced colitis by inhibiting ATP-mediated activation of colonic mast cells through ceraimide-LMIR3 binding.	dss	30-33	CD300 molecule like family member F	Mus musculus	128-133
26861489-5	2016	In a retrospective study, MMP-11 expression was correlated with clinicopathologic features and with disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	127-130	matrix metallopeptidase 11	Homo sapiens	26-32
26279300-5	2016	We show that ApoA-I is expressed at higher levels in the proximal compared with the distal part of the colon and its ablation in mice results in exaggerated DSS-induced colitis and disruption of epithelial architecture in larger areas of the large intestine.	dss	157-160	apolipoprotein A-I	Mus musculus	13-19
26279300-7	2016	Genetic interference with ApoA-I levels in vivo impacted on the number, size and distribution of AOM/DSS-induced colon tumors.	dss	101-104	apolipoprotein A-I	Mus musculus	26-32
26479868-2	2016	We recently demonstrated that beta-arrestin1 (beta-arr1) deficiency strikingly attenuates dextran sodium sulfate (DSS)-induced colitis in mice.	dss	114-117	arrestin, beta 1	Mus musculus	46-55
27376145-8	2016	pT3 patients in Toronto had an improved 10 year DSS (43% vs. 22%, p = 0.025).	dss	48-51	zinc finger protein 135	Homo sapiens	0-3
26786981-6	2016	RESULTS: Genetic deletion or pharmacological inhibition of Gal-3 significantly attenuate DSS-induced colitis.	dss	89-92	lectin, galactose binding, soluble 3	Mus musculus	59-64
26786981-8	2016	Peritoneal macrophages isolated from untreated Gal-3(-/-) mice and treated in vitro with bacterial lipopolysaccharide or DSS produce lower amounts of tumour necrosis factor alpha [TNF-alpha] and interleukin beta [IL-1beta] when compared with wild type [WT] cells.	dss	121-124	lectin, galactose binding, soluble 3	Mus musculus	47-52
26786981-8	2016	Peritoneal macrophages isolated from untreated Gal-3(-/-) mice and treated in vitro with bacterial lipopolysaccharide or DSS produce lower amounts of tumour necrosis factor alpha [TNF-alpha] and interleukin beta [IL-1beta] when compared with wild type [WT] cells.	dss	121-124	tumor necrosis factor	Mus musculus	180-189
26786981-8	2016	Peritoneal macrophages isolated from untreated Gal-3(-/-) mice and treated in vitro with bacterial lipopolysaccharide or DSS produce lower amounts of tumour necrosis factor alpha [TNF-alpha] and interleukin beta [IL-1beta] when compared with wild type [WT] cells.	dss	121-124	interleukin 1 beta	Mus musculus	213-221
26786981-10	2016	However, the total number of CD11c+ CD80+ DCs which produce pro-inflammatory cytokines, as well as TNF-alpha and IL-1beta producing CD45+ CD11c- Ly6G+ neutrophils were significantly lower in colons of Gal-3(-/-) DSS-treated mice.	dss	212-215	integrin alpha X	Mus musculus	29-34
26786981-10	2016	However, the total number of CD11c+ CD80+ DCs which produce pro-inflammatory cytokines, as well as TNF-alpha and IL-1beta producing CD45+ CD11c- Ly6G+ neutrophils were significantly lower in colons of Gal-3(-/-) DSS-treated mice.	dss	212-215	CD80 antigen	Mus musculus	36-40
26786981-12	2016	CONCLUSIONS: Gal-3 expression promotes acute DSS-induced colitis and plays an important pro-inflammatory role in the induction phase of colitis by promoting the activation of NLRP3 inflammasome and production of IL-1beta in macrophages.	dss	45-48	lectin, galactose binding, soluble 3	Mus musculus	13-18
26994916-7	2016	cT1 gastric cancer was finally diagnosed as pathological stages IA to III, and the 5-year DSS was 99.7 % in pathological stage IA, 96.9 % in pathological stage IB, and 81 % in pathological stage II/III.	dss	90-93	cardiotrophin 1	Homo sapiens	0-3
26983700-6	2016	When all Prx expression intensities were grouped as a single variable, we discovered that high total Prx intensity correlated with favourable DSS (p = 0.024) and OS (p = 0.035) but not with PFS.	dss	142-145	periaxin	Homo sapiens	101-104
27053333-3	2016	The five-year disease-specific survival (DSS) rates were significantly better in IPC than in IDC (97.5% vs. 93%, respectively; P &lt; 0.001).	dss	41-44	lamin A/C	Homo sapiens	93-96
27162541-5	2016	RESULTS: Patients with FOXM1-overexpressing angiosarcoma had significantly shorter survival (both for disease-specific survival [DSS] and event-free survival [EFS]) than other patients (5-year DSS, 23.5% vs. 47.1%, P = 0.013; and 5-year EFS, 5.5% vs. 28.7%, P = 0.004).	dss	129-132	forkhead box M1	Homo sapiens	23-28
27162541-5	2016	RESULTS: Patients with FOXM1-overexpressing angiosarcoma had significantly shorter survival (both for disease-specific survival [DSS] and event-free survival [EFS]) than other patients (5-year DSS, 23.5% vs. 47.1%, P = 0.013; and 5-year EFS, 5.5% vs. 28.7%, P = 0.004).	dss	193-196	forkhead box M1	Homo sapiens	23-28
27162541-6	2016	FOXM1 overexpression was also an independent prognostic factor for both DSS and EFS in Cox multivariate analyses (hazard ratio [HR] 2.84, 95% confidence interval [CI] 1.10-5.81, P = 0.039; and HR 4.16, 95%CI 2.03-8.67, P = 0.0001, respectively).	dss	72-75	forkhead box M1	Homo sapiens	0-5
27050089-7	2016	In addition, AOM/DSS treatment greatly induced the infiltration of Gr-1(high)/CD11b(high) neutrophils to the colon, which led to the production of tumor necrosis factor alpha and inducible nitric oxide synthase.	dss	17-20	integrin alpha M	Mus musculus	78-83
26910375-7	2016	Moreover, GEN-27 inhibited AOM/DSS-induced p65 and beta-catenin nuclear translocation, while promoted the expression of CDX2, APC, and AXIN2.	dss	31-34	RELA proto-oncogene, NF-kB subunit	Homo sapiens	43-46
27050089-7	2016	In addition, AOM/DSS treatment greatly induced the infiltration of Gr-1(high)/CD11b(high) neutrophils to the colon, which led to the production of tumor necrosis factor alpha and inducible nitric oxide synthase.	dss	17-20	tumor necrosis factor	Mus musculus	147-174
27050089-7	2016	In addition, AOM/DSS treatment greatly induced the infiltration of Gr-1(high)/CD11b(high) neutrophils to the colon, which led to the production of tumor necrosis factor alpha and inducible nitric oxide synthase.	dss	17-20	nitric oxide synthase 2, inducible	Mus musculus	179-210
26910375-7	2016	Moreover, GEN-27 inhibited AOM/DSS-induced p65 and beta-catenin nuclear translocation, while promoted the expression of CDX2, APC, and AXIN2.	dss	31-34	catenin beta 1	Homo sapiens	51-63
27058552-5	2016	The administration of GB to DSS-treated mice also reduced the numbers and inhibited the activation of colon-infiltrating T cells, neutrophils, intestinal CD103(-)CD11c+ dendritic cells (cDCs), and macrophages.	dss	28-31	integrin alpha X	Mus musculus	154-167
27046199-8	2016	R-spondin expression was found to be highly dynamic and differentially regulated during C. rodentium infection and dextran sodium sulfate (DSS) colitis, with notably high levels of Rspo3 expression during DSS colitis, and high levels of Rspo2 expression during C. rodentium infection, specifically in susceptible mice.	dss	139-142	R-spondin 1	Mus musculus	0-9
27046199-8	2016	R-spondin expression was found to be highly dynamic and differentially regulated during C. rodentium infection and dextran sodium sulfate (DSS) colitis, with notably high levels of Rspo3 expression during DSS colitis, and high levels of Rspo2 expression during C. rodentium infection, specifically in susceptible mice.	dss	205-208	R-spondin 1	Mus musculus	0-9
27058552-6	2016	In addition, GB treatment promoted the migration of CD103+CD11c+ cDCs and expansion of Foxp3+ regulatory T cells in the colons of DSS-treated mice.	dss	130-133	forkhead box P3	Mus musculus	87-92
25782372-5	2016	Patients who had p16-negative cancers had the highest DSS when treated with surgery + adjuvant therapy (S+RT)/CRT.	dss	54-57	cyclin dependent kinase inhibitor 2A	Homo sapiens	17-20
27076853-9	2016	After correlating protein expression status with key clinicopathological features, the prognostic significance of CSF2 protein expression was determined for disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	184-187	colony stimulating factor 2	Homo sapiens	114-118
26349931-11	2016	RESULTS: DSS-induced colitis and colitis induced by trinitrobenzene sulfonic acid were markedly exacerbated in GnT-V transgenic mice compared with wild-type mice.	dss	9-12	mannoside acetylglucosaminyltransferase 5	Mus musculus	111-116
26511677-9	2016	Cytoplasmic beta-catenin overexpression was independently associated with a longer DSS (P = .0007), and E-cadherin overexpression was found to be an independent risk factor for poor OS (P = .030).	dss	83-86	catenin beta 1	Homo sapiens	12-24
27023252-10	2016	In the whole section study, palladin positivity was significantly lower (p = 0.0037) in the CF group (5/19) with a significantly better DSS (p = 0.0144) than in the SF group (16/22), suggesting that stromal palladin expression is a surrogate indicator of the treatment effect after chemoradiation therapy.	dss	136-139	palladin, cytoskeletal associated protein	Homo sapiens	28-36
27110358-7	2016	The FUC + DSS group (P &lt; 0 001), LAM + DSS group (P &lt; 0 05) and LAMFUC + DSS group (P &lt; 0 001) had lower IL-6 mRNA abundance relative to the DSS group.	dss	10-13	interleukin 6	Sus scrofa	114-118
27110358-7	2016	The FUC + DSS group (P &lt; 0 001), LAM + DSS group (P &lt; 0 05) and LAMFUC + DSS group (P &lt; 0 001) had lower IL-6 mRNA abundance relative to the DSS group.	dss	42-45	interleukin 6	Sus scrofa	114-118
27110358-7	2016	The FUC + DSS group (P &lt; 0 001), LAM + DSS group (P &lt; 0 05) and LAMFUC + DSS group (P &lt; 0 001) had lower IL-6 mRNA abundance relative to the DSS group.	dss	42-45	interleukin 6	Sus scrofa	114-118
27076853-12	2016	Univariate analysis found a close correlation between CSF2 overexpression and unfavorable prognosis for both DSS (UTUC, p=0.0001; UBUC, p&lt;0.0001) and MeFS (UTUC, p=0.0001; UBUC, p=0.0002).	dss	109-112	colony stimulating factor 2	Homo sapiens	54-58
27110358-7	2016	The FUC + DSS group (P &lt; 0 001), LAM + DSS group (P &lt; 0 05) and LAMFUC + DSS group (P &lt; 0 001) had lower IL-6 mRNA abundance relative to the DSS group.	dss	42-45	interleukin 6	Sus scrofa	114-118
27076853-13	2016	High expression of CSF2 still remained prognostically for DSS (UTUC, p=0.015; UBUC, p=0.004) and MeFS (UTUC, p=0.008; UBUC, p=0.027) in multivariate comparison.	dss	58-61	colony stimulating factor 2	Homo sapiens	19-23
26847386-7	2016	Tumor necrosis factor-alpha, interleukin-1beta and interferon gamma mRNA expression levels were significantly downregulated in the colon tissue of DSS mice treated with 5-FU compared with the untreated DSS mice (P&lt;0.05).	dss	147-150	tumor necrosis factor	Mus musculus	0-27
26846574-6	2016	The densities of CgA-, serotonin-, PYY- and enteroglucagon-producing cells were significantly higher, and those of PP- and somatostatin-producing cells were significantly lower in the DSS-G, DSS-Q and control groups than in the DSS group.	dss	184-187	chromogranin A	Rattus norvegicus	17-20
26846574-6	2016	The densities of CgA-, serotonin-, PYY- and enteroglucagon-producing cells were significantly higher, and those of PP- and somatostatin-producing cells were significantly lower in the DSS-G, DSS-Q and control groups than in the DSS group.	dss	184-187	pancreatic polypeptide	Rattus norvegicus	115-117
26174764-3	2016	We show that Clec9A-diphtheria toxin receptor (DTR) mice after depletion of CD103(+)CD11b(-) DCs developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack of CD103(+)CD11b(+) DCs in Clec4a4-DTR mice did not exacerbate intestinal inflammation.	dss	148-151	heparin-binding EGF-like growth factor	Mus musculus	13-45
26174764-3	2016	We show that Clec9A-diphtheria toxin receptor (DTR) mice after depletion of CD103(+)CD11b(-) DCs developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack of CD103(+)CD11b(+) DCs in Clec4a4-DTR mice did not exacerbate intestinal inflammation.	dss	148-151	heparin-binding EGF-like growth factor	Mus musculus	47-50
26174764-3	2016	We show that Clec9A-diphtheria toxin receptor (DTR) mice after depletion of CD103(+)CD11b(-) DCs developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack of CD103(+)CD11b(+) DCs in Clec4a4-DTR mice did not exacerbate intestinal inflammation.	dss	148-151	integrin alpha E, epithelial-associated	Mus musculus	190-195
26174764-3	2016	We show that Clec9A-diphtheria toxin receptor (DTR) mice after depletion of CD103(+)CD11b(-) DCs developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack of CD103(+)CD11b(+) DCs in Clec4a4-DTR mice did not exacerbate intestinal inflammation.	dss	148-151	integrin alpha M	Mus musculus	198-203
26174764-3	2016	We show that Clec9A-diphtheria toxin receptor (DTR) mice after depletion of CD103(+)CD11b(-) DCs developed severe, low-dose dextran sodium sulfate (DSS)-induced colitis, whereas the lack of CD103(+)CD11b(+) DCs in Clec4a4-DTR mice did not exacerbate intestinal inflammation.	dss	148-151	heparin-binding EGF-like growth factor	Mus musculus	222-225
26220168-6	2016	Wild-type and dendritic cell-specific HIF-1alpha knockout mice were treated with 3% DSS for 7 days.	dss	84-87	hypoxia inducible factor 1, alpha subunit	Mus musculus	38-48
26220168-7	2016	Knockout of HIF-1alpha in DCs led to a significantly larger loss of body weight in mice with DSS-induced colitis than in control mice.	dss	93-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	12-22
26349655-4	2016	We demonstrate that beta7-integrin deficiency protects recombination-activating gene-2 (RAG-2)-deficient mice from dextran sodium sulfate (DSS)-induced colitis and coincides with decreased numbers of colonic effector monocytes.	dss	139-142	recombination activating gene 2	Mus musculus	55-86
26349655-4	2016	We demonstrate that beta7-integrin deficiency protects recombination-activating gene-2 (RAG-2)-deficient mice from dextran sodium sulfate (DSS)-induced colitis and coincides with decreased numbers of colonic effector monocytes.	dss	139-142	recombination activating gene 2	Mus musculus	88-93
26349655-6	2016	Importantly, adoptive transfer of CD115(+) wild-type (WT) monocytes partially restored the susceptibility of RAG-2/beta7-integrin double-deficient mice to DSS-induced colitis, thereby demonstrating the functional importance of beta7-integrin-expressing monocytes for the development of DSS colitis.	dss	155-158	recombination activating gene 2	Mus musculus	109-114
26575331-5	2016	In the replication, two of these 18 SNPs showed nominal significance: the VDBP rs12512631 T &gt; C was associated with a better DSS [combined hazards ratio (HR) = 0.66]; and the same for RXRA rs7850212 C &gt; A (combined HR = 0.38), which were further confirmed by the Fine and Gray competing-risks regression model.	dss	128-131	GC vitamin D binding protein	Homo sapiens	74-78
26575331-5	2016	In the replication, two of these 18 SNPs showed nominal significance: the VDBP rs12512631 T &gt; C was associated with a better DSS [combined hazards ratio (HR) = 0.66]; and the same for RXRA rs7850212 C &gt; A (combined HR = 0.38), which were further confirmed by the Fine and Gray competing-risks regression model.	dss	128-131	retinoid X receptor alpha	Homo sapiens	187-191
26847386-7	2016	Tumor necrosis factor-alpha, interleukin-1beta and interferon gamma mRNA expression levels were significantly downregulated in the colon tissue of DSS mice treated with 5-FU compared with the untreated DSS mice (P&lt;0.05).	dss	147-150	interleukin 1 beta	Mus musculus	29-46
26847386-7	2016	Tumor necrosis factor-alpha, interleukin-1beta and interferon gamma mRNA expression levels were significantly downregulated in the colon tissue of DSS mice treated with 5-FU compared with the untreated DSS mice (P&lt;0.05).	dss	147-150	interferon gamma	Mus musculus	51-67
26847386-7	2016	Tumor necrosis factor-alpha, interleukin-1beta and interferon gamma mRNA expression levels were significantly downregulated in the colon tissue of DSS mice treated with 5-FU compared with the untreated DSS mice (P&lt;0.05).	dss	202-205	interferon gamma	Mus musculus	51-67
26847386-9	2016	Furthermore, 5-FU treatment significantly reduced p-NF-kappaB-p56 protein expression levels in the colon tissue of DSS-treated mice (P&lt;0.05).	dss	115-118	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	52-61
26847386-9	2016	Furthermore, 5-FU treatment significantly reduced p-NF-kappaB-p56 protein expression levels in the colon tissue of DSS-treated mice (P&lt;0.05).	dss	115-118	interferon-induced protein with tetratricopeptide repeats 1	Mus musculus	62-65
26691887-7	2016	Immunohistochemical analysis showed that PCA significantly inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression in the colon of DSS-treated rats.	dss	172-175	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	69-85
26721217-10	2016	The administration of RWE at dose of 100mg/kg also suppressed the TNBS- or DSS-stimulated expression of TNF-alpha, IL-1beta, monocyte chemotactic protein-1, inducible nitric oxide, and intercellular adhesion molecule-1.	dss	75-78	tumor necrosis factor	Rattus norvegicus	104-113
26721217-10	2016	The administration of RWE at dose of 100mg/kg also suppressed the TNBS- or DSS-stimulated expression of TNF-alpha, IL-1beta, monocyte chemotactic protein-1, inducible nitric oxide, and intercellular adhesion molecule-1.	dss	75-78	interleukin 1 beta	Rattus norvegicus	115-123
26721217-10	2016	The administration of RWE at dose of 100mg/kg also suppressed the TNBS- or DSS-stimulated expression of TNF-alpha, IL-1beta, monocyte chemotactic protein-1, inducible nitric oxide, and intercellular adhesion molecule-1.	dss	75-78	C-C motif chemokine ligand 2	Rattus norvegicus	125-155
26721217-10	2016	The administration of RWE at dose of 100mg/kg also suppressed the TNBS- or DSS-stimulated expression of TNF-alpha, IL-1beta, monocyte chemotactic protein-1, inducible nitric oxide, and intercellular adhesion molecule-1.	dss	75-78	intercellular adhesion molecule 1	Rattus norvegicus	185-218
26841120-8	2016	In contrast, CD200tg mice showed less sensitivity to DSS compared with WT mice, with attenuation of all of the features seen in other groups.	dss	53-56	CD200 antigen	Mus musculus	13-18
26841120-10	2016	CONCLUSIONS: The CD200:CD200R axis plays an immunoregulatory role in control of DSS induced colitis in mice.	dss	80-83	CD200 antigen	Mus musculus	17-22
26841120-10	2016	CONCLUSIONS: The CD200:CD200R axis plays an immunoregulatory role in control of DSS induced colitis in mice.	dss	80-83	CD200 receptor 1	Mus musculus	23-29
26320084-4	2016	AIMS: We investigated whether delivery of the GSK3beta inhibitor, lithium chloride (LiCl), during the recovery period from acute DSS-induced colitis in mice promoted colonic regeneration and ameliorated disease symptoms.	dss	129-132	glycogen synthase kinase 3 beta	Mus musculus	46-54
26320084-11	2016	RESULTS: Lithium treatments promoted recovery from acute DSS-induced damage by increasing expression of Myc transcripts, MYC proteins, and expression of a subset of Wnt/MYC target genes in the colonic epithelium.	dss	57-60	myelocytomatosis oncogene	Mus musculus	104-107
26320084-11	2016	RESULTS: Lithium treatments promoted recovery from acute DSS-induced damage by increasing expression of Myc transcripts, MYC proteins, and expression of a subset of Wnt/MYC target genes in the colonic epithelium.	dss	57-60	myelocytomatosis oncogene	Mus musculus	121-124
26320084-11	2016	RESULTS: Lithium treatments promoted recovery from acute DSS-induced damage by increasing expression of Myc transcripts, MYC proteins, and expression of a subset of Wnt/MYC target genes in the colonic epithelium.	dss	57-60	myelocytomatosis oncogene	Mus musculus	169-172
26710992-9	2016	Multivariate analysis showed that old-old age and TNM stage &gt;= II were major independent risk factors for the DSS rate.	dss	113-116	teneurin transmembrane protein 1	Homo sapiens	50-53
26691887-7	2016	Immunohistochemical analysis showed that PCA significantly inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression in the colon of DSS-treated rats.	dss	172-175	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	87-92
26691887-7	2016	Immunohistochemical analysis showed that PCA significantly inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression in the colon of DSS-treated rats.	dss	172-175	nitric oxide synthase 2	Rattus norvegicus	98-129
26691887-7	2016	Immunohistochemical analysis showed that PCA significantly inhibited cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) protein expression in the colon of DSS-treated rats.	dss	172-175	nitric oxide synthase 2	Rattus norvegicus	131-135
26311121-11	2016	Multivariate analysis identified the Ang"s profile, EGFR and ZSNU as independent predictors of both DSS and OS.	dss	100-103	angiogenin	Homo sapiens	37-40
26311121-11	2016	Multivariate analysis identified the Ang"s profile, EGFR and ZSNU as independent predictors of both DSS and OS.	dss	100-103	epidermal growth factor receptor	Homo sapiens	52-56
26311121-12	2016	Using RPA, the three risk factors were used to devise a prognostic scoring system that successfully predicted DSS in both p16-positive and -negative cases.	dss	110-113	cyclin dependent kinase inhibitor 2A	Homo sapiens	122-125
26089223-9	2016	Immunoneutralization of CCL5 but not CXCL4 reduces tissue damage, CXC chemokine expression, and neutrophil recruitment in DSS-treated animals.	dss	122-125	chemokine (C-C motif) ligand 5	Mus musculus	24-28
26878795-6	2016	Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice.	dss	272-275	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	67-76
26878795-6	2016	Further studies revealed that fisetin suppressed the activation of NF-kappaB (p65) by inhibiting IkappaBalpha phosphorylation and NF-kappaB (p65)-DNA binding activity and attenuated the phosphorylation of Akt and the p38, but not ERK and JNK MAPKs in the colon tissues of DSS-exposed mice.	dss	272-275	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	78-81
26878795-9	2016	These results suggest that fisetin exerts anti-inflammatory activity via inhibition of Akt, p38 MAPK and NF-kappaB signaling in the colon tissues of DSS-exposed mice.	dss	149-152	thymoma viral proto-oncogene 1	Mus musculus	87-90
26878795-9	2016	These results suggest that fisetin exerts anti-inflammatory activity via inhibition of Akt, p38 MAPK and NF-kappaB signaling in the colon tissues of DSS-exposed mice.	dss	149-152	mitogen-activated protein kinase 14	Mus musculus	92-100
26878795-9	2016	These results suggest that fisetin exerts anti-inflammatory activity via inhibition of Akt, p38 MAPK and NF-kappaB signaling in the colon tissues of DSS-exposed mice.	dss	149-152	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	105-114
26918061-8	2016	Further evaluations of the prognostic significance of SPOCK1 for disease-specific survival (DSS) and metastasis-free survival (MeFS) were analyzed.	dss	92-95	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	54-60
26358253-5	2016	In DSS-treated wild-type mice, the preneoplastic lesions which did not eventually evolve to adenomas resided in a colitic microenvironment characterized by a balanced upregulation of both BMP ligands, i.e., Bmp4/7 and BMP inhibitors, such as chordin, noggin, and gremlin-1.	dss	3-6	bone morphogenetic protein 4	Mus musculus	207-211
26358253-5	2016	In DSS-treated wild-type mice, the preneoplastic lesions which did not eventually evolve to adenomas resided in a colitic microenvironment characterized by a balanced upregulation of both BMP ligands, i.e., Bmp4/7 and BMP inhibitors, such as chordin, noggin, and gremlin-1.	dss	3-6	chordin	Mus musculus	242-249
26358253-5	2016	In DSS-treated wild-type mice, the preneoplastic lesions which did not eventually evolve to adenomas resided in a colitic microenvironment characterized by a balanced upregulation of both BMP ligands, i.e., Bmp4/7 and BMP inhibitors, such as chordin, noggin, and gremlin-1.	dss	3-6	noggin	Mus musculus	251-257
26358253-5	2016	In DSS-treated wild-type mice, the preneoplastic lesions which did not eventually evolve to adenomas resided in a colitic microenvironment characterized by a balanced upregulation of both BMP ligands, i.e., Bmp4/7 and BMP inhibitors, such as chordin, noggin, and gremlin-1.	dss	3-6	gremlin 1, DAN family BMP antagonist	Mus musculus	263-272
26358253-7	2016	By contrast to DSS-treated wild-type controls, the inflammation-associated Bmp4 upregulation was abolished, and the BMP signaling suppression was further enhanced by a particularly high increase of gremlin-1 expression.	dss	15-18	gremlin 1, DAN family BMP antagonist	Mus musculus	198-207
26818094-9	2016	However, stratified survival analysis based on the gender showed that in mRNA cohort, downregulation of TRPV6 was associated with an unfavorable 3-year DSS in patients with male (47.3 % vs 63.6 %, P = 0.027) and with favorable 3-year DSS in patients with female (66.7 % vs 43.0 %, P = 0.031).	dss	152-155	transient receptor potential cation channel subfamily V member 6	Homo sapiens	104-109
26818094-9	2016	However, stratified survival analysis based on the gender showed that in mRNA cohort, downregulation of TRPV6 was associated with an unfavorable 3-year DSS in patients with male (47.3 % vs 63.6 %, P = 0.027) and with favorable 3-year DSS in patients with female (66.7 % vs 43.0 %, P = 0.031).	dss	234-237	transient receptor potential cation channel subfamily V member 6	Homo sapiens	104-109
26818094-11	2016	Male patients with downregulation of TRPV6 had a poor 3-year DSS (20.0 % vs 57.1 %,P &lt; 0.001) while female counterparts showed an enhanced 3-year DSS (56.1 % vs 28.6 %, P = 0.005).	dss	61-64	transient receptor potential cation channel subfamily V member 6	Homo sapiens	37-42
26793111-6	2015	Mechanically, celastrol treatment significantly prevented AOM/DSS-induced up-regulation of expression levels of oncologic markers including mutated p53 and phospho-p53, beta-catenin and proliferating cell nuclear antigen (PCNA).	dss	62-65	transformation related protein 53, pseudogene	Mus musculus	148-151
26793111-6	2015	Mechanically, celastrol treatment significantly prevented AOM/DSS-induced up-regulation of expression levels of oncologic markers including mutated p53 and phospho-p53, beta-catenin and proliferating cell nuclear antigen (PCNA).	dss	62-65	transformation related protein 53, pseudogene	Mus musculus	164-167
26793111-6	2015	Mechanically, celastrol treatment significantly prevented AOM/DSS-induced up-regulation of expression levels of oncologic markers including mutated p53 and phospho-p53, beta-catenin and proliferating cell nuclear antigen (PCNA).	dss	62-65	proliferating cell nuclear antigen	Mus musculus	222-226
26682925-3	2016	Moreover, in a dextran sodium sulfate (DSS)-induced colitis model in mice, a high-fat diet increases portal LPS level and promotes hepatic inflammation and fibrosis.	dss	39-42	toll-like receptor 4	Mus musculus	108-111
26682925-9	2016	In the DSS group, portal LPS levels were elevated at 4 weeks, and the proportions of Clostridium cluster XI in the fecal microbiota were elevated.	dss	7-10	toll-like receptor 4	Mus musculus	25-28
26682925-10	2016	In addition, levels of serum transaminase, number of lobular inflammatory cells, F4/80 staining-positive area, and levels of inflammatory cytokines were all elevated in the DSS group.	dss	173-176	adhesion G protein-coupled receptor E1	Mus musculus	81-86
25772234-4	2016	Here, we showed that DUSP10 knockout (KO) mice had increased intestinal epithelial cell (IEC) proliferation and migration and developed less severe colitis than wild-type (WT) mice in response to dextran sodium sulphate (DSS) treatment, which is associated with increased ERK1/2 activation and Kruppel-like factor 5 (KLF5) expression in IEC.	dss	221-224	dual specificity phosphatase 10	Mus musculus	21-27
25772234-5	2016	In line with increased IEC proliferation, DUSP10 KO mice developed more colon tumours with increased severity compared with WT mice in response to administration of DSS and azoxymethane (AOM).	dss	165-168	dual specificity phosphatase 10	Mus musculus	42-48
26918044-9	2016	NDN expression was further correlated with clinicopathological features and disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	103-106	necdin, MAGE family member	Homo sapiens	0-3
26918044-12	2016	In univariate analysis, NDN overexpression not only predicted worse DSS and MeFS in both the UTUC and UBUC groups, it also served as an independent prognostic factor for DSS and MeFS in multivariate analysis (all P&lt;0.05).	dss	68-71	necdin, MAGE family member	Homo sapiens	24-27
26918044-12	2016	In univariate analysis, NDN overexpression not only predicted worse DSS and MeFS in both the UTUC and UBUC groups, it also served as an independent prognostic factor for DSS and MeFS in multivariate analysis (all P&lt;0.05).	dss	170-173	necdin, MAGE family member	Homo sapiens	24-27
26918061-11	2016	The prognosis of SPOCK1 of UC showed high SPOCK1 expression had significantly worse DSS and MeFS.	dss	84-87	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	17-23
26918061-11	2016	The prognosis of SPOCK1 of UC showed high SPOCK1 expression had significantly worse DSS and MeFS.	dss	84-87	SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1	Homo sapiens	42-48
26597886-10	2016	Compared with controls, Crhr2(-/-) mice showed increased mortality in the DSS healing protocol.	dss	74-77	corticotropin releasing hormone receptor 2	Mus musculus	24-29
26645352-8	2016	The worsening of the faecal condition was accompanied by a reduced number of neutrophils and increased expression of interferon-gamma in the colons of DSS-treated mice.	dss	151-154	interferon gamma	Mus musculus	117-133
26645352-9	2016	Furthermore, an increased expression of TLR2, TLR6 and pro-inflammatory markers including chemokine (C-C motif) ligand 2, interleukin (IL)-1beta, tumour necrosis factor alpha and IL-6 was found in DSS-treated mice with L. rhamnosus supplementation.	dss	197-200	toll-like receptor 2	Mus musculus	40-44
27074165-9	2016	Additionally, the expression of VEGFR-3 mRNA was significantly upregulated in VEGF-C156S mice compared to DSS-treated mice after induction of colitis (42.0+-1.4 vs 3.5+-0.4, P&lt;0.001).	dss	106-109	FMS-like tyrosine kinase 4	Mus musculus	32-39
26645352-9	2016	Furthermore, an increased expression of TLR2, TLR6 and pro-inflammatory markers including chemokine (C-C motif) ligand 2, interleukin (IL)-1beta, tumour necrosis factor alpha and IL-6 was found in DSS-treated mice with L. rhamnosus supplementation.	dss	197-200	chemokine (C-C motif) ligand 2	Mus musculus	90-120
26645352-9	2016	Furthermore, an increased expression of TLR2, TLR6 and pro-inflammatory markers including chemokine (C-C motif) ligand 2, interleukin (IL)-1beta, tumour necrosis factor alpha and IL-6 was found in DSS-treated mice with L. rhamnosus supplementation.	dss	197-200	interleukin 1 beta	Mus musculus	122-144
26645352-9	2016	Furthermore, an increased expression of TLR2, TLR6 and pro-inflammatory markers including chemokine (C-C motif) ligand 2, interleukin (IL)-1beta, tumour necrosis factor alpha and IL-6 was found in DSS-treated mice with L. rhamnosus supplementation.	dss	197-200	interleukin 6	Mus musculus	179-183
24996171-5	2016	Five-year disease-specific survival (DSS) for T1a, T1b, T2, T3, and T4 glottic SCC was 100%, 95%, 78%, 79%, and 53%, respectively.	dss	37-40	serpin family B member 3	Homo sapiens	79-82
27387244-2	2016	The loss of SHOX gene functionality is assumed to be responsible for the Leri-Weill syndrome formation and the disproportionate short stature (DSS).	dss	143-146	short stature homeobox	Homo sapiens	12-16
26386585-4	2015	The results showed that DSS decreased daily weight gain, induced colonic inflammation, suppressed the expression of antioxidant enzymes and tight junctions, and activated NF-kappaB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathways.	dss	24-27	kelch like ECH associated protein 1	Homo sapiens	271-276
26590314-6	2016	Defective recovery of Il1rl2(-/-) mice could be rescued by an aryl hydrocarbon receptor agonist, which was sufficient to restore IL-22 expression and promote full recovery from DSS-induced damage.	dss	177-180	interleukin 1 receptor-like 2	Mus musculus	22-28
26590314-6	2016	Defective recovery of Il1rl2(-/-) mice could be rescued by an aryl hydrocarbon receptor agonist, which was sufficient to restore IL-22 expression and promote full recovery from DSS-induced damage.	dss	177-180	aryl-hydrocarbon receptor	Mus musculus	62-87
27610005-5	2016	Colitis was induced in wild-type (WT) and Nlrp3-/- mice by treatment with dextran sulphate sodium (DSS).	dss	99-102	NLR family, pyrin domain containing 3	Mus musculus	42-47
27610005-7	2016	DSS-treated Nlrp3-/- mice exhibited increased numbers of colonic foxp3+ T cells that expressed significantly lower levels of IL-10 but increased IL-17.	dss	0-3	NLR family, pyrin domain containing 3	Mus musculus	12-17
27610005-7	2016	DSS-treated Nlrp3-/- mice exhibited increased numbers of colonic foxp3+ T cells that expressed significantly lower levels of IL-10 but increased IL-17.	dss	0-3	forkhead box P3	Mus musculus	65-70
27610005-7	2016	DSS-treated Nlrp3-/- mice exhibited increased numbers of colonic foxp3+ T cells that expressed significantly lower levels of IL-10 but increased IL-17.	dss	0-3	interleukin 10	Mus musculus	125-130
27610005-7	2016	DSS-treated Nlrp3-/- mice exhibited increased numbers of colonic foxp3+ T cells that expressed significantly lower levels of IL-10 but increased IL-17.	dss	0-3	interleukin 17A	Mus musculus	145-150
26699544-6	2015	Kaplan-Meier analysis of the complete study cohort revealed that patients with high-NETO2 tumors had a significantly shorter disease-specific survival (DSS) than those with low-NETO2 tumors (p &lt; 0.001).	dss	152-155	neuropilin and tolloid like 2	Homo sapiens	84-89
26699544-7	2015	Importantly, high levels of NETO2 protein predicted poor DSS for patients with early stage tumors (p = 0.027) and for those with advanced stage tumors (p = 0.020).	dss	57-60	neuropilin and tolloid like 2	Homo sapiens	28-33
26514773-0	2015	Matrix metalloproteinase 9-induced increase in intestinal epithelial tight junction permeability contributes to the severity of experimental DSS colitis.	dss	141-144	matrix metallopeptidase 9	Mus musculus	0-26
26514773-6	2015	The DSS-induced increase in the colonic permeability was accompanied by an increase in intestinal epithelial cell MMP-9 expression in WT mice.	dss	4-7	matrix metallopeptidase 9	Mus musculus	114-119
26514773-7	2015	The DSS-induced increase in intestinal permeability and the severity of DSS colitis was found to be attenuated in MMP-9(-/-) mice.	dss	4-7	matrix metallopeptidase 9	Mus musculus	114-119
26514773-8	2015	The colonic protein expression of myosin light chain kinase (MLCK) and phospho-MLC was found to be significantly increased after DSS administration in WT mice but not in MMP-9(-/-) mice.	dss	129-132	myosin light chain kinase 3	Mus musculus	34-59
26514773-8	2015	The colonic protein expression of myosin light chain kinase (MLCK) and phospho-MLC was found to be significantly increased after DSS administration in WT mice but not in MMP-9(-/-) mice.	dss	129-132	myosin light chain kinase 3	Mus musculus	61-65
26514773-8	2015	The colonic protein expression of myosin light chain kinase (MLCK) and phospho-MLC was found to be significantly increased after DSS administration in WT mice but not in MMP-9(-/-) mice.	dss	129-132	megalencephalic leukoencephalopathy with subcortical cysts 1 homolog (human)	Mus musculus	61-64
26514773-9	2015	The DSS-induced increase in colonic permeability and colonic inflammation was attenuated in MLCK(-/-) mice and MLCK inhibitor ML-7-treated WT mice.	dss	4-7	myosin light chain kinase 3	Mus musculus	92-96
26514773-9	2015	The DSS-induced increase in colonic permeability and colonic inflammation was attenuated in MLCK(-/-) mice and MLCK inhibitor ML-7-treated WT mice.	dss	4-7	myosin light chain kinase 3	Mus musculus	111-115
26514773-10	2015	The DSS-induced increase in colonic surface epithelial cell MLCK mRNA was abolished in MMP-9(-/-) mice.	dss	4-7	myosin light chain kinase 3	Mus musculus	60-64
26514773-10	2015	The DSS-induced increase in colonic surface epithelial cell MLCK mRNA was abolished in MMP-9(-/-) mice.	dss	4-7	matrix metallopeptidase 9	Mus musculus	87-92
26588227-9	2015	The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration.	dss	154-157	tumor necrosis factor	Mus musculus	71-80
26588227-9	2015	The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration.	dss	154-157	interleukin 6	Mus musculus	82-86
26588227-9	2015	The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration.	dss	154-157	interleukin 17A	Mus musculus	88-104
26588227-9	2015	The pro-inflammatory cytokine expression in the mouse colon, including TNF-alpha, IL-6, INF-gamma, IL-17, and IL-1beta, was significantly up-regulated by DSS treatment, but was inhibited upon PL administration.	dss	154-157	interleukin 1 beta	Mus musculus	110-118
26505975-5	2015	NHE8(-/-) mice are also susceptible to DSS treatment.	dss	39-42	solute carrier family 9 (sodium/hydrogen exchanger), member 8	Mus musculus	0-4
26505975-6	2015	Real-time PCR detected a remarkable increase in the expression of IL-1beta, IL-6, TNF-alpha, and IL-4 in DSS-treated NHE8(-/-) mice compared with DSS-treated wild-type littermates.	dss	105-108	interleukin 1 beta	Mus musculus	66-74
26505975-6	2015	Real-time PCR detected a remarkable increase in the expression of IL-1beta, IL-6, TNF-alpha, and IL-4 in DSS-treated NHE8(-/-) mice compared with DSS-treated wild-type littermates.	dss	105-108	interleukin 6	Mus musculus	76-80
26505975-6	2015	Real-time PCR detected a remarkable increase in the expression of IL-1beta, IL-6, TNF-alpha, and IL-4 in DSS-treated NHE8(-/-) mice compared with DSS-treated wild-type littermates.	dss	105-108	tumor necrosis factor	Mus musculus	82-91
26505975-6	2015	Real-time PCR detected a remarkable increase in the expression of IL-1beta, IL-6, TNF-alpha, and IL-4 in DSS-treated NHE8(-/-) mice compared with DSS-treated wild-type littermates.	dss	105-108	interleukin 4	Mus musculus	97-101
26505975-6	2015	Real-time PCR detected a remarkable increase in the expression of IL-1beta, IL-6, TNF-alpha, and IL-4 in DSS-treated NHE8(-/-) mice compared with DSS-treated wild-type littermates.	dss	105-108	solute carrier family 9 (sodium/hydrogen exchanger), member 8	Mus musculus	117-121
26590314-4	2016	Surprisingly, IL-36R-deficient (Il1rl2(-/-)) mice exhibited defective recovery following DSS-induced damage and impaired closure of colonic mucosal biopsy wounds, which coincided with impaired neutrophil accumulation in the wound bed.	dss	89-92	interleukin 1 receptor-like 2	Mus musculus	32-38
26503474-6	2015	ApoA-I &gt;= 1.025 g/L was an independent prognostic factor for superior DSS, DMFS, and LRFS in multivariate analysis.	dss	73-76	apolipoprotein A1	Homo sapiens	0-6
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	dss	126-129	glutathione peroxidase 1	Homo sapiens	92-96
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	dss	126-129	glutathione peroxidase 4	Homo sapiens	98-102
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	dss	126-129	occludin	Homo sapiens	104-112
26386585-0	2015	Pyrrolidine Dithiocarbamate Inhibits NF-KappaB Activation and Upregulates the Expression of Gpx1, Gpx4, Occludin, and ZO-1 in DSS-Induced Colitis.	dss	126-129	tight junction protein 1	Homo sapiens	118-122
26386585-4	2015	The results showed that DSS decreased daily weight gain, induced colonic inflammation, suppressed the expression of antioxidant enzymes and tight junctions, and activated NF-kappaB and nuclear factor erythroid 2-related factor 2/Kelch-like ECH-associated protein 1 (Nrf2/Keap1) signaling pathways.	dss	24-27	NFE2 like bZIP transcription factor 2	Homo sapiens	266-270
26386585-5	2015	PDTC significantly upregulated (P &lt; 0.05) Gpx1, Gpx4, occludin, and ZO-1 expressions in the DSS-induced colitis model.	dss	95-98	occludin	Homo sapiens	57-65
26386585-5	2015	PDTC significantly upregulated (P &lt; 0.05) Gpx1, Gpx4, occludin, and ZO-1 expressions in the DSS-induced colitis model.	dss	95-98	tight junction protein 1	Homo sapiens	71-75
26135313-6	2015	Expressions of ANLN were analysed to identify correlations with various clinicopathological parameters, disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	131-134	anillin, actin binding protein	Homo sapiens	15-19
26466602-6	2015	Moreover, the xenogeneic TNF-alpha protein vaccine could protect mice from acute and chronic colitis induced by dextran sodium sulfate (DSS).	dss	136-139	tumor necrosis factor	Mus musculus	25-34
25410748-7	2015	RESULTS: DSS ingestion induced a more marked colitis in animals receiving the purified diet, as reflected by higher histological score and increased MPO activity.	dss	9-12	myeloperoxidase	Rattus norvegicus	149-152
25410748-9	2015	Also, in these animals, administration of DSS induced a significant increase in interleukin (IL)-1alpha, IL-1beta and IL-6.	dss	42-45	interleukin 1 alpha	Rattus norvegicus	80-103
25410748-9	2015	Also, in these animals, administration of DSS induced a significant increase in interleukin (IL)-1alpha, IL-1beta and IL-6.	dss	42-45	interleukin 1 beta	Rattus norvegicus	105-113
25410748-9	2015	Also, in these animals, administration of DSS induced a significant increase in interleukin (IL)-1alpha, IL-1beta and IL-6.	dss	42-45	interleukin 6	Rattus norvegicus	118-122
26514300-4	2015	Oral administration of OA significantly inhibited DSS-induced colon shortening, macroscopic score, and myeloperoxidase activity.	dss	50-53	myeloperoxidase	Mus musculus	103-118
26514300-6	2015	OA treatment increased the DSS-suppressed expression of tight junction proteins such as ZO-1, occludin, and claudin-1 in the colon.	dss	27-30	occludin	Mus musculus	94-102
26514300-6	2015	OA treatment increased the DSS-suppressed expression of tight junction proteins such as ZO-1, occludin, and claudin-1 in the colon.	dss	27-30	claudin 1	Mus musculus	108-117
26514300-7	2015	Moreover, OA treatment inhibited DSS-induced expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17, the activation of NF-kappaB and mitogen-activated protein kinases, and increased IL-10 expression.	dss	33-36	tumor necrosis factor	Mus musculus	59-86
26514300-7	2015	Moreover, OA treatment inhibited DSS-induced expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17, the activation of NF-kappaB and mitogen-activated protein kinases, and increased IL-10 expression.	dss	33-36	interleukin 1 beta	Mus musculus	88-110
26514300-7	2015	Moreover, OA treatment inhibited DSS-induced expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17, the activation of NF-kappaB and mitogen-activated protein kinases, and increased IL-10 expression.	dss	33-36	interleukin 17A	Mus musculus	116-121
26514300-7	2015	Moreover, OA treatment inhibited DSS-induced expression of tumor necrosis factor-alpha, interleukin (IL)-1beta, and IL-17, the activation of NF-kappaB and mitogen-activated protein kinases, and increased IL-10 expression.	dss	33-36	interleukin 10	Mus musculus	204-209
26734588-12	2015	The level of IL-1beta in DSS mice was much higher than control group (P &lt; 0.01), but there was no difference among several DSS groups.	dss	25-28	interleukin 1 beta	Mus musculus	13-21
26135313-9	2015	Notably, univariable analysis showed that overexpression of ANLN in the nucleus was significantly associated with a poor DSS (p=0.006) and MeFS (p=0.010), and multivariable analysis showed that it was an independent predictor of adverse DSS outcome (p=0.031, relative risk 1.535).	dss	121-124	anillin, actin binding protein	Homo sapiens	60-64
26135313-9	2015	Notably, univariable analysis showed that overexpression of ANLN in the nucleus was significantly associated with a poor DSS (p=0.006) and MeFS (p=0.010), and multivariable analysis showed that it was an independent predictor of adverse DSS outcome (p=0.031, relative risk 1.535).	dss	237-240	anillin, actin binding protein	Homo sapiens	60-64
26135313-10	2015	Low expression of ANLN in the cytoplasm was strongly associated with a poor DSS (p=0.045) and MeFS (p=0.041) in univariable analysis but not in Cox regression analysis.	dss	76-79	anillin, actin binding protein	Homo sapiens	18-22
26135313-12	2015	Since high nuclear expression of ANLN is also an independent predictor of poor DSS, it is a useful prognostic marker of UCUT.	dss	79-82	anillin, actin binding protein	Homo sapiens	33-37
26491118-12	2015	Furthermore, mice fed cellulose+DSS exhibited 1.42, 11.5, 8.48, and 35.5 times greater (P &lt; 0.05) colon mRNA expression of tumor necrosis factor alpha (Tnfa) and interleukin (Il) 1b, Il6, and Il17a, respectively, and 7.10 times greater (P &lt; 0.05) expression of C-X-C motif ligand 1 (Cxc1) compared with mice fed PF+DSS.	dss	32-35	tumor necrosis factor	Mus musculus	126-153
26491118-12	2015	Furthermore, mice fed cellulose+DSS exhibited 1.42, 11.5, 8.48, and 35.5 times greater (P &lt; 0.05) colon mRNA expression of tumor necrosis factor alpha (Tnfa) and interleukin (Il) 1b, Il6, and Il17a, respectively, and 7.10 times greater (P &lt; 0.05) expression of C-X-C motif ligand 1 (Cxc1) compared with mice fed PF+DSS.	dss	32-35	tumor necrosis factor	Mus musculus	155-159
26491118-12	2015	Furthermore, mice fed cellulose+DSS exhibited 1.42, 11.5, 8.48, and 35.5 times greater (P &lt; 0.05) colon mRNA expression of tumor necrosis factor alpha (Tnfa) and interleukin (Il) 1b, Il6, and Il17a, respectively, and 7.10 times greater (P &lt; 0.05) expression of C-X-C motif ligand 1 (Cxc1) compared with mice fed PF+DSS.	dss	32-35	interleukin 1 beta	Mus musculus	165-184
26491118-12	2015	Furthermore, mice fed cellulose+DSS exhibited 1.42, 11.5, 8.48, and 35.5 times greater (P &lt; 0.05) colon mRNA expression of tumor necrosis factor alpha (Tnfa) and interleukin (Il) 1b, Il6, and Il17a, respectively, and 7.10 times greater (P &lt; 0.05) expression of C-X-C motif ligand 1 (Cxc1) compared with mice fed PF+DSS.	dss	32-35	interleukin 6	Mus musculus	186-189
26491118-12	2015	Furthermore, mice fed cellulose+DSS exhibited 1.42, 11.5, 8.48, and 35.5 times greater (P &lt; 0.05) colon mRNA expression of tumor necrosis factor alpha (Tnfa) and interleukin (Il) 1b, Il6, and Il17a, respectively, and 7.10 times greater (P &lt; 0.05) expression of C-X-C motif ligand 1 (Cxc1) compared with mice fed PF+DSS.	dss	32-35	interleukin 17A	Mus musculus	195-200
26656376-10	2015	Homozygous deletion or promoter methylation of MTAP gene were identified to be significantly associated with MTAP protein deficiency (P &lt; 0.001).MTAP deficiency was correlated with an aggressive phenotype and independently predictive of worse DSS and DMFS, suggesting its role in disease progression and as an independent prognostic biomarker of NPC, which potentially offers new strategy of targeted treatment for patients lacking MTAP expression.	dss	246-249	methylthioadenosine phosphorylase	Homo sapiens	47-51
25717051-8	2015	The expression of pore-forming claudin 2 was upregulated and claudin 7 was downregulated in DSS-induced colitis.	dss	92-95	claudin 2	Rattus norvegicus	31-40
26713054-6	2015	On univariate analysis, CRP, ESR, and NLR were significantly associated with DFS and DSS.	dss	85-88	C-reactive protein	Homo sapiens	24-27
26713054-7	2015	On multivariate analysis, CRP and NLR were independently significant prognostic variables for DSS and DFS respectively (P=0.013, P=0.021).	dss	94-97	C-reactive protein	Homo sapiens	26-29
26713054-8	2015	When PIS was constructed with combination of CRP and NLR, it was independently and significantly associated with both DFS and DSS (P=0.006, P=0.010).	dss	126-129	C-reactive protein	Homo sapiens	45-48
26096696-6	2015	Significantly, Kaplan-Meier analysis revealed that SOX4 nuclear overexpression (SOX4-N) was associated with poorer progression-free survival (PFS) and disease-specific survival (DSS) in diffusely infiltrating astrocytoma patients (P &lt; 0.05).	dss	178-181	SRY-box transcription factor 4	Homo sapiens	51-55
26096696-6	2015	Significantly, Kaplan-Meier analysis revealed that SOX4 nuclear overexpression (SOX4-N) was associated with poorer progression-free survival (PFS) and disease-specific survival (DSS) in diffusely infiltrating astrocytoma patients (P &lt; 0.05).	dss	178-181	SRY-box transcription factor 4	Homo sapiens	80-84
25717051-8	2015	The expression of pore-forming claudin 2 was upregulated and claudin 7 was downregulated in DSS-induced colitis.	dss	92-95	claudin 7	Rattus norvegicus	61-70
25743327-11	2015	The 5-year disease-specific survival (DSS) was 52.2 % for patients identified with RA-UPS/MFH (n = 55) compared with 76.4 % for patients with unmatched sporadic UPS/MFH (n = 1,013; p &lt; 0.001).	dss	38-41	forkhead box P1	Homo sapiens	83-93
26431797-5	2015	In this study, we have discovered that CPT-11 promotes macrophage infiltration into intestinal tissues and activates the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, resulting in a robust IL-1beta response and colonic inflammation similar to DSS (dextran sodium sulfate) induced experimental colitis.	dss	271-274	NLR family pyrin domain containing 3	Homo sapiens	174-179
26431797-5	2015	In this study, we have discovered that CPT-11 promotes macrophage infiltration into intestinal tissues and activates the NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome, resulting in a robust IL-1beta response and colonic inflammation similar to DSS (dextran sodium sulfate) induced experimental colitis.	dss	271-274	interleukin 1 beta	Homo sapiens	217-225
26716076-4	2015	This review will detail the role of ClC-2 in intestinal barrier function during intestinal disorders, including experimental ischemia/reperfusion injury and dextran sodium sulfate (DSS)-induced inflammatory bowel disease.	dss	181-184	chloride voltage-gated channel 2	Homo sapiens	36-41
26431492-5	2015	Here we demonstrate that CHI3L1 (aka Brp39) knockout (KO) mice treated with azoxymethane (AOM)/dextran sulphate sodium (DSS) developed severe colitis but lesser incidence of CAC as compared to that in wild-type (WT) mice.	dss	120-123	chitinase-like 1	Mus musculus	25-31
26431492-5	2015	Here we demonstrate that CHI3L1 (aka Brp39) knockout (KO) mice treated with azoxymethane (AOM)/dextran sulphate sodium (DSS) developed severe colitis but lesser incidence of CAC as compared to that in wild-type (WT) mice.	dss	120-123	chitinase-like 1	Mus musculus	37-42
26304465-12	2015	5-ASA treatment and PAK1 deletion impeded tumor multiplicity and dysplastic lesions in AOM/DSS mice.	dss	91-94	p21 (RAC1) activated kinase 1	Mus musculus	20-24
25902372-12	2015	For p16-positive patients, Kaplan-Meier estimates of OS, DSS, and DFS were significantly higher for surgically treated patients than for the nonsurgical group (chi(2)(1) = 7.335 for log-rank P = .007, chi(2)(1) = 8.607 for log-rank P = .003, and chi(2)(1) = 7.763 for log-rank P = .005, respectively).	dss	57-60	cyclin dependent kinase inhibitor 2A	Homo sapiens	4-7
26381705-0	2015	Bilirubin prevents acute DSS-induced colitis by inhibiting leukocyte infiltration and suppressing upregulation of inducible nitric oxide synthase.	dss	25-28	nitric oxide synthase 2, inducible	Mus musculus	114-145
26381705-10	2015	In conclusion, bilirubin prevents DSS-induced colitis by inhibiting the migration of leukocytes across the vascular endothelium and by suppressing iNOS expression.	dss	34-37	nitric oxide synthase 2, inducible	Mus musculus	147-151
25743327-11	2015	The 5-year disease-specific survival (DSS) was 52.2 % for patients identified with RA-UPS/MFH (n = 55) compared with 76.4 % for patients with unmatched sporadic UPS/MFH (n = 1,013; p &lt; 0.001).	dss	38-41	forkhead box P1	Homo sapiens	90-93
25743327-12	2015	A matched-cohort analysis also demonstrated that the 5-year DSS was significantly worse for RA-UPS/MFH (52.2 vs 73.4 %; p = 0.002).	dss	60-63	forkhead box P1	Homo sapiens	92-102
25807183-3	2015	Ccn1(dm/dm) mice exhibited high mortality, impaired mucosal healing, and diminished interleukin-6 (IL-6) expression during the repair phase of DSS-induced colitis compared with wild-type mice, despite having comparable severity of initial inflammation and tissue injury.	dss	143-146	cellular communication network factor 1	Mus musculus	0-4
25131582-2	2015	Our previous study demonstrated that PhIP, combined with the dextrin sulfate sodium (DSS)-induced colitis, induces colon carcinogenesis in hCYP1A mice.	dss	85-88	cytochrome P450 family 27 subfamily B member 1	Homo sapiens	139-144
25131582-8	2015	Since mutations that activate Wnt signal is a major driving force for human colorectal cancers, we conclude that the mutated beta-catenin is the driver in PhIP/DSS-induced colon carcinogenesis.	dss	160-163	catenin beta 1	Homo sapiens	125-137
25807183-5	2015	Administration of purified CCN1 protein fully rescued Ccn1(dm/dm) mice from DSS-induced mortality, restored IEC proliferation and enhanced mucosal healing, whereas delivery of IL-6 partially rectified these defects.	dss	76-79	cellular communication network factor 1	Mus musculus	27-31
25807183-6	2015	CCN1 therapy accelerated mucosal healing and recovery from DSS-induced colitis even in wild-type mice.	dss	59-62	cellular communication network factor 1	Mus musculus	0-4
26497661-7	2015	RESULTS: In contrast to wild type (WT) mice, Dcir1 (-/-) mice exhibited mild body weight loss during the course of DSS colitis accompanied by reduced colonic inflammation.	dss	115-118	C-type lectin domain family 4, member a2	Mus musculus	45-50
26497661-13	2015	CONCLUSION: Dcir1 enhances the pathogenesis of DSS colitis by altering neutrophil recruitment and their functions.	dss	47-50	C-type lectin domain family 4, member a2	Mus musculus	12-17
26469707-9	2015	RESULTS: Low expression of lamin A associated with lymph node positivity (p&lt;0.01) but not with other clinicopathological variables and low expression had a borderline independent significant association with DSS (HR = 0.4; 95% CI 0.2-1.0; p = 0.052).	dss	211-214	lamin A/C	Homo sapiens	27-32
26469707-12	2015	Low expression of lamin B2 correlated with lymph node positivity (p&lt;0.01) and predicted unfavorable DSS (HR = 0.4; 95% CI 0.2-1.0; p = 0.047).	dss	103-106	lamin B2	Homo sapiens	18-26
26461935-9	2015	When the area containing tumors was compared with the entire colonic area of each mouse, the tumor burden was decreased in AOM/DSS-treated TSP-1-/- versus wild type (WT) mice.	dss	127-130	thrombospondin 1	Mus musculus	139-144
26461935-11	2015	AOM-DSS treatment of TSP-1-/- mice resulted in significant deregulation of genes involved in transcription, canonical Wnt signaling, transport, defense response, regulation of epithelial cell proliferation and metabolism.	dss	4-7	thrombospondin 1	Mus musculus	21-26
25418110-9	2015	High MTDH expression was associated with recurrence-free survival (RFS) and disease-specific survival rate (DSS) (P = 0 014, P = 0 001, respectively).	dss	108-111	metadherin	Homo sapiens	5-9
26346586-8	2015	RESULTS: Univariable analysis revealed a significant association between an elevated plasma fibrinogen level and DSS (hazard ratio (HR) 1.70, 95% CI 1.07-2.76, p = 0.026) that remained significant in multivariable analysis (HR 1.71, 95% CI 1.02-2.85; p = 0.042).	dss	113-116	fibrinogen beta chain	Homo sapiens	92-102
26346586-10	2015	In patients with ER/PR+, HER2- tumors, plasma fibrinogen was associated with DSS in univariable (HR 2.65, 95% CI 1.15-6.14, p = 0.023) and multivariable analysis (HR 3.63, 95% CI 1.37-9.64, p = 0.010).	dss	77-80	fibrinogen beta chain	Homo sapiens	46-56
26346586-11	2015	Furthermore, in those patients, the estimated c-index of the multivariable model for DSS was 0.755 without fibrinogen and 0.785 when fibrinogen was added.	dss	85-88	fibrinogen beta chain	Homo sapiens	107-117
26346586-11	2015	Furthermore, in those patients, the estimated c-index of the multivariable model for DSS was 0.755 without fibrinogen and 0.785 when fibrinogen was added.	dss	85-88	fibrinogen beta chain	Homo sapiens	133-143
26439841-4	2015	In mice, EPRAP deficiency exacerbated colitis induced by dextran sodium sulfate (DSS) treatment.	dss	81-84	fem-1 homolog A	Homo sapiens	9-14
26439841-5	2015	Wild-type (WT) or EPRAP-deficient recipients transplanted with EPRAP-deficient bone marrow developed more severe DSS-induced colitis than WT or EPRAP-deficient recipients of WT bone marrow.	dss	113-116	fem-1 homolog A	Homo sapiens	18-23
26439841-5	2015	Wild-type (WT) or EPRAP-deficient recipients transplanted with EPRAP-deficient bone marrow developed more severe DSS-induced colitis than WT or EPRAP-deficient recipients of WT bone marrow.	dss	113-116	fem-1 homolog A	Homo sapiens	63-68
26439841-6	2015	In the context of colitis-associated tumorigenesis, both systemic EPRAP null mutation and EPRAP-deficiency in the bone marrow enhanced intestinal polyp formation induced by azoxymethane (AOM)/DSS treatment.	dss	192-195	fem-1 homolog A	Homo sapiens	66-71
26439841-6	2015	In the context of colitis-associated tumorigenesis, both systemic EPRAP null mutation and EPRAP-deficiency in the bone marrow enhanced intestinal polyp formation induced by azoxymethane (AOM)/DSS treatment.	dss	192-195	fem-1 homolog A	Homo sapiens	90-95
26439841-7	2015	Administration of an EP4-selective agonist, ONO-AE1-329, ameliorated DSS-induced colitis in WT, but not in EPRAP-deficient mice.	dss	69-72	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	21-24
26439841-8	2015	EPRAP deficiency increased the levels of the phosphorylated forms of p105, MEK, and ERK, resulting in activation of stromal macrophages in DSS-induced colitis.	dss	139-142	fem-1 homolog A	Homo sapiens	0-5
26439841-8	2015	EPRAP deficiency increased the levels of the phosphorylated forms of p105, MEK, and ERK, resulting in activation of stromal macrophages in DSS-induced colitis.	dss	139-142	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	69-73
26439841-9	2015	Macrophages of DSS-treated EPRAP-deficient mice exhibited a marked increase in the expression of pro-inflammatory genes, relative to WT mice.	dss	15-18	fem-1 homolog A	Homo sapiens	27-32
26439841-10	2015	By contrast, forced expression of EPRAP in macrophages ameliorated DSS-induced colitis and AOM/DSS-induced intestinal polyp formation.	dss	67-70	fem-1 homolog A	Homo sapiens	34-39
26439841-10	2015	By contrast, forced expression of EPRAP in macrophages ameliorated DSS-induced colitis and AOM/DSS-induced intestinal polyp formation.	dss	95-98	fem-1 homolog A	Homo sapiens	34-39
25418110-10	2015	Cox regression analysis showed that high MTDH expression was independent prognostic indicators for RFS and DSS in patients with PTC (P = 0 023 and P = 0 035, respectively).	dss	107-110	metadherin	Homo sapiens	41-45
26055138-9	2015	A miR214 chemical inhibitor blocked this circuit and reduced the severity of DSS-induced colitis in mice, as well as the number and size of tumors that formed in mice given azoxymethane and DSS.	dss	77-80	microRNA 214	Mus musculus	2-8
26014805-5	2015	Tumor necrosis factor-alpha (TNF-alpha), interleukin 6 and NO2-/NO3- levels were also upregulated in the plasma, and a decrease in body weight and colon length was observed in DSS-treated mice.	dss	176-179	tumor necrosis factor	Mus musculus	0-27
26014805-5	2015	Tumor necrosis factor-alpha (TNF-alpha), interleukin 6 and NO2-/NO3- levels were also upregulated in the plasma, and a decrease in body weight and colon length was observed in DSS-treated mice.	dss	176-179	tumor necrosis factor	Mus musculus	29-38
26263169-12	2015	In addition, 6-gingerol suppressed DSS-elevated production of proinflammatory cytokines (IL-1beta, TNFalpha, and IL-12).	dss	35-38	interleukin 1 beta	Mus musculus	89-97
26263169-12	2015	In addition, 6-gingerol suppressed DSS-elevated production of proinflammatory cytokines (IL-1beta, TNFalpha, and IL-12).	dss	35-38	tumor necrosis factor	Mus musculus	99-107
26055138-9	2015	A miR214 chemical inhibitor blocked this circuit and reduced the severity of DSS-induced colitis in mice, as well as the number and size of tumors that formed in mice given azoxymethane and DSS.	dss	190-193	microRNA 214	Mus musculus	2-8
26134251-6	2015	CD11b(+) macrophages infiltrating the lamina propria were, however, reduced in DSS-treated mice reconstituted with CHOP KO bone marrow.	dss	79-82	integrin alpha M	Mus musculus	0-5
26609032-6	2015	RESULTS: SMAR1 transgenic mice were resistant to dextran sodium sulphate (DSS) induced colitis with decreased expression of Th1 and Th17 specific cytokines.	dss	74-77	BTG3 associated nuclear protein	Mus musculus	9-14
26031185-2	2015	We hypothesized that prior voluntary exercise would attenuate colonic inflammation and ameliorate clinical symptoms in dextran sulphate sodium (DSS)-induced ulcerative colitis by increasing glucocorticoid production and up-regulating PPAR-gamma activity in the colon.	dss	144-147	peroxisome proliferator activated receptor gamma	Mus musculus	234-244
26401072-11	2015	Large intestine ACE shedding was increased in 5% DSS group (41.5 +- 9.0 ng/mL vs 20.9 +- 5.2 ng/mL, P = 0.034).	dss	49-52	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	16-19
26401072-13	2015	CONCLUSION: Intestinal ACE shedding is increased by DSS-induced intestinal inflammation and parallels local corticosterone production.	dss	52-55	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	23-26
26212544-8	2015	Therefore, we used the widely applied NLRP3 inflammasome-related models of dextran sodium sulfate (DSS)-induced colitis and LPS-induced endotoxin shock to confirm the novel pharmacological effect of levornidazole in vivo.	dss	99-102	NLR family pyrin domain containing 3	Homo sapiens	38-43
26722606-6	2015	Morphology observation, HE staining, and p53 and beta-catenin expression detection confirmed that drinking 3% DSS and 3% DSS combined with AOM intraperitoneal injection can successfully establish colitis and colitis associated colorectal cancer models.	dss	110-113	tumor protein p53	Homo sapiens	41-44
26722606-6	2015	Morphology observation, HE staining, and p53 and beta-catenin expression detection confirmed that drinking 3% DSS and 3% DSS combined with AOM intraperitoneal injection can successfully establish colitis and colitis associated colorectal cancer models.	dss	110-113	catenin beta 1	Homo sapiens	49-61
26722606-6	2015	Morphology observation, HE staining, and p53 and beta-catenin expression detection confirmed that drinking 3% DSS and 3% DSS combined with AOM intraperitoneal injection can successfully establish colitis and colitis associated colorectal cancer models.	dss	121-124	tumor protein p53	Homo sapiens	41-44
26722606-6	2015	Morphology observation, HE staining, and p53 and beta-catenin expression detection confirmed that drinking 3% DSS and 3% DSS combined with AOM intraperitoneal injection can successfully establish colitis and colitis associated colorectal cancer models.	dss	121-124	catenin beta 1	Homo sapiens	49-61
26094822-9	2015	In AOM/DSS-treated mice, administration of ghrelin significantly suppressed tumor formation in the colon.	dss	7-10	ghrelin	Mus musculus	43-50
26071411-10	2015	RESULTS: The rats of the HHcy + DSS group had significantly higher myeloperoxidase [MPO] activity, DAI score, and histological score.	dss	32-35	myeloperoxidase	Rattus norvegicus	67-82
26071411-10	2015	RESULTS: The rats of the HHcy + DSS group had significantly higher myeloperoxidase [MPO] activity, DAI score, and histological score.	dss	32-35	myeloperoxidase	Rattus norvegicus	84-87
26071411-14	2015	CONCLUSIONS: HHcy aggravated DSS-induced colitis by stimulating IL-17 expression via the p38/cPLA2/COX2/PGE2 signalling pathway.	dss	29-32	interleukin 17A	Rattus norvegicus	64-69
26071411-14	2015	CONCLUSIONS: HHcy aggravated DSS-induced colitis by stimulating IL-17 expression via the p38/cPLA2/COX2/PGE2 signalling pathway.	dss	29-32	mitogen activated protein kinase 14	Rattus norvegicus	89-92
26071411-14	2015	CONCLUSIONS: HHcy aggravated DSS-induced colitis by stimulating IL-17 expression via the p38/cPLA2/COX2/PGE2 signalling pathway.	dss	29-32	phospholipase A2 group IVA	Rattus norvegicus	93-98
26071411-14	2015	CONCLUSIONS: HHcy aggravated DSS-induced colitis by stimulating IL-17 expression via the p38/cPLA2/COX2/PGE2 signalling pathway.	dss	29-32	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	99-103
26347659-6	2015	Additionally, failure to up-regulate PVN Galphai2 proteins during high salt-intake contributes to the pathophysiology of Dahl salt-sensitive (DSS) hypertension.	dss	142-145	G protein subunit alpha i2	Rattus norvegicus	41-49
26622660-8	2015	The expression level of PPAR-gamma in the intestinal tissue was also increased in the AOM/DSS/5-ASA group compared with AOM/DSS group (P&lt;0.001).	dss	90-93	peroxisome proliferator activated receptor gamma	Homo sapiens	24-34
26622660-8	2015	The expression level of PPAR-gamma in the intestinal tissue was also increased in the AOM/DSS/5-ASA group compared with AOM/DSS group (P&lt;0.001).	dss	124-127	peroxisome proliferator activated receptor gamma	Homo sapiens	24-34
26287771-7	2015	Results showed that high CD44 expression in RCC was a poor prognostic marker for five-year OS (RR = 0.69, 95% CI 0.60-0.78) in a fixed-effects model and for five-year DSS (RR = 0.46, 95% CI 0.27-0.80) and five-year DFS (RR = 0.63, 95% CI 0.43-0.93) in a random-effects model.	dss	167-170	CD44 molecule (Indian blood group)	Homo sapiens	25-29
26035389-9	2015	Gpa33(-/-) mice also exhibited rapid onset and reduced resolution of DSS-induced colitis, and a striking increase in the number of colitis-associated tumours produced by treatment with the colon-specific mutagen azoxymethane (AOM) followed by two cycles of DSS.	dss	69-72	glycoprotein A33 (transmembrane)	Mus musculus	0-5
26269954-2	2015	We found that Dectin-1-deficient (Clec7a(-/-)) mice were refractory to both dextran sodium sulfate (DSS)- and CD45RB(high)CD4(+) T cell-induced colitis, and that this resistance was associated with an increase in regulatory T (Treg) cells.	dss	100-103	C-type lectin domain family 7, member a	Mus musculus	14-22
24764155-6	2015	SLPI expression correlates with OS (hazard ratio [HR] = 0.61) and DSS (HR = 0.47) in multivariate analysis.	dss	66-69	secretory leukocyte peptidase inhibitor	Homo sapiens	0-4
26196182-7	2015	Moreover, dextran sodium sulfate (DSS)-induced inflammatory responses were downregulated by GADD34 deficiency.	dss	34-37	protein phosphatase 1, regulatory subunit 15A	Mus musculus	92-98
26196182-11	2015	CONCLUSIONS: These results indicated that GADD34 upregulated pro-inflammatory mediator production leading to a higher tumour burden following azoxymethane (AOM)/DSS treatment.	dss	161-164	protein phosphatase 1, regulatory subunit 15A	Mus musculus	42-48
26241646-8	2015	A higher neutrophil influx and enhanced IL-6, MCP-1 and KC production was observed in Nur77-deficient colons after DSS-treatment.	dss	115-118	interleukin 6	Mus musculus	40-44
26241646-8	2015	A higher neutrophil influx and enhanced IL-6, MCP-1 and KC production was observed in Nur77-deficient colons after DSS-treatment.	dss	115-118	mast cell protease 1	Mus musculus	46-51
25914165-10	2015	Multivariable Cox-regression analysis of the cohort of individuals aged &gt;= 70 years revealed that stage, age, comorbidity, and sex remained independent variables (P &lt; 0.05) predicting DSS.	dss	190-193	cytochrome c oxidase subunit 8A	Homo sapiens	14-17
26035389-9	2015	Gpa33(-/-) mice also exhibited rapid onset and reduced resolution of DSS-induced colitis, and a striking increase in the number of colitis-associated tumours produced by treatment with the colon-specific mutagen azoxymethane (AOM) followed by two cycles of DSS.	dss	257-260	glycoprotein A33 (transmembrane)	Mus musculus	0-5
26265756-0	2015	Local chemerin levels are positively associated with DSS-induced colitis but constitutive loss of CMKLR1 does not protect against development of colitis.	dss	53-56	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	6-14
25596854-3	2015	METHODS: Experimental colitis was induced in MFG-E8 knockout (KO) and wild-type (WT) mice by dextran sodium sulfate (DSS) administration.	dss	117-120	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	45-51
26265756-3	2015	In the current study, we demonstrate that expression, secretion, and processing of chemerin, a potent chemoattractant for cells expressing chemokine-like receptor 1 (CMKLR1), increased in the cecum and colon along a gradient positively associated with the severity of inflammation in dextran sodium sulfate (DSS)-induced colitis.	dss	308-311	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	83-91
26265756-4	2015	We also show that levels of circulating bioactive chemerin increased following DSS treatment.	dss	79-82	retinoic acid receptor responder (tazarotene induced) 2	Mus musculus	50-58
26265756-5	2015	At both 6-8 and 14-16 weeks of age, CMKLR1 knockout mice developed signs of clinical illness more slowly than wild type and had changes in circulating cytokine levels, increased spleen weight, and increased local chemerin secretion following DSS treatment.	dss	242-245	chemokine-like receptor 1	Mus musculus	36-42
26034351-2	2015	METHODS: The dextran sodium sulfate (DSS) was used for the induction of colitis in both TSP-1 deficient (TSP-1(-/-)) and wild type (WT) mice during 7 d. While mice were receiving the DSS dissolved in the drinking water, the ABT-898 peptide was dissolved in sterile 5% glucose solution and delivered using mini pumps subcutaneously implanted.	dss	37-40	tumor suppressor region 1	Mus musculus	88-93
25802070-9	2015	DHCA also showed therapeutic effects in the mouse DSS-induced colitis model by suppressing the production of TNF-alpha and IL-1beta and thus preventing weight loss and colon shrinkage.	dss	50-53	tumor necrosis factor	Mus musculus	109-118
25802070-9	2015	DHCA also showed therapeutic effects in the mouse DSS-induced colitis model by suppressing the production of TNF-alpha and IL-1beta and thus preventing weight loss and colon shrinkage.	dss	50-53	interleukin 1 beta	Mus musculus	123-131
25112884-9	2015	MiR-133alpha levels were increased in TNBS (2 day) and DSS (5 day) colitis, while NTR1 deficient DSS-exposed mice had reduced miR-133alpha levels, compared to wild-type colitic mice.	dss	97-100	neurotensin receptor 1	Mus musculus	82-86
25934334-4	2015	HAS3 protein expression statuses were further correlated with clinicopathological parameters and evaluated the prognostic significance for disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	166-169	hyaluronan synthase 3	Homo sapiens	0-4
25934334-6	2015	HAS3 underexpression not only predicted poorer DSS and MeFS with univariate analysis, but also indicated dismal DSS and MeFS in multivariate analysis.	dss	47-50	hyaluronan synthase 3	Homo sapiens	0-4
25934334-6	2015	HAS3 underexpression not only predicted poorer DSS and MeFS with univariate analysis, but also indicated dismal DSS and MeFS in multivariate analysis.	dss	112-115	hyaluronan synthase 3	Homo sapiens	0-4
26003890-5	2015	On the other hand, expression of octn1 gene product and ERGO concentration in intestinal tissues of DSS-treated mice were higher than in controls.	dss	100-103	solute carrier family 22 (organic cation transporter), member 4	Mus musculus	33-38
26003890-6	2015	Interestingly, lamina propria mononuclear cells (LPMCs) isolated from DSS-treated mice contained ERGO and showed [(3)H]ERGO uptake and Octn1 expression, whereas ERGO was undetectable in LPMCs of control mice.	dss	70-73	solute carrier family 22 (organic cation transporter), member 4	Mus musculus	135-140
25877924-5	2015	Fyn KO mice consistently displayed significantly worse DSS-induced disease than WT, correlating with decreased IL-10 and increased IL-17 in splenocytes and the gut; Fyn KO mice failed to thrive after removal of the DSS water.	dss	55-58	Fyn proto-oncogene	Mus musculus	0-3
25877924-5	2015	Fyn KO mice consistently displayed significantly worse DSS-induced disease than WT, correlating with decreased IL-10 and increased IL-17 in splenocytes and the gut; Fyn KO mice failed to thrive after removal of the DSS water.	dss	215-218	Fyn proto-oncogene	Mus musculus	0-3
25877924-5	2015	Fyn KO mice consistently displayed significantly worse DSS-induced disease than WT, correlating with decreased IL-10 and increased IL-17 in splenocytes and the gut; Fyn KO mice failed to thrive after removal of the DSS water.	dss	215-218	Fyn proto-oncogene	Mus musculus	165-168
25877924-6	2015	Analysis of chimeric mice indicated that the increased sensitivity to DSS was due to the lack of Fyn kinase in hematopoietic, but not stromal, cells, in accordance with Fyn(+) T cell increases in WT mice exposed to DSS and Fyn KO mice having a reduced number of CD4(+)Foxp3(+) cells in baseline or colitic conditions and a reduced capacity to induce Foxp3 expression in vitro.	dss	70-73	CD4 antigen	Mus musculus	262-265
25877924-6	2015	Analysis of chimeric mice indicated that the increased sensitivity to DSS was due to the lack of Fyn kinase in hematopoietic, but not stromal, cells, in accordance with Fyn(+) T cell increases in WT mice exposed to DSS and Fyn KO mice having a reduced number of CD4(+)Foxp3(+) cells in baseline or colitic conditions and a reduced capacity to induce Foxp3 expression in vitro.	dss	70-73	forkhead box P3	Mus musculus	268-273
25877924-6	2015	Analysis of chimeric mice indicated that the increased sensitivity to DSS was due to the lack of Fyn kinase in hematopoietic, but not stromal, cells, in accordance with Fyn(+) T cell increases in WT mice exposed to DSS and Fyn KO mice having a reduced number of CD4(+)Foxp3(+) cells in baseline or colitic conditions and a reduced capacity to induce Foxp3 expression in vitro.	dss	70-73	forkhead box P3	Mus musculus	350-355
25877924-8	2015	Contrary to our expectation, the absence of Fyn kinase resulted in greater DSS-induced disease, and analysis of chimeric mice indicated that leukocyte Fyn kinase is beneficial in limiting colitis.	dss	75-78	Fyn proto-oncogene	Mus musculus	44-47
26030277-3	2015	Removing Wnt5a or Ror2 in adult mice suppressed dextran sodium sulfate (DSS)-induced colitis.	dss	72-75	wingless-type MMTV integration site family, member 5A	Mus musculus	9-14
26030277-3	2015	Removing Wnt5a or Ror2 in adult mice suppressed dextran sodium sulfate (DSS)-induced colitis.	dss	72-75	receptor tyrosine kinase-like orphan receptor 2	Mus musculus	18-22
26030277-4	2015	It also attenuated the DSS-dependent increase in inflammatory cytokine production and decreased interferon-gamma (IFN-gamma)-producing CD4(+) Th1 cell numbers in the colon.	dss	23-26	interferon gamma	Mus musculus	96-112
26030277-4	2015	It also attenuated the DSS-dependent increase in inflammatory cytokine production and decreased interferon-gamma (IFN-gamma)-producing CD4(+) Th1 cell numbers in the colon.	dss	23-26	interferon gamma	Mus musculus	114-123
26030277-4	2015	It also attenuated the DSS-dependent increase in inflammatory cytokine production and decreased interferon-gamma (IFN-gamma)-producing CD4(+) Th1 cell numbers in the colon.	dss	23-26	CD4 antigen	Mus musculus	135-138
26030277-5	2015	Wnt5a was highly expressed in stromal fibroblasts in ulcerative lesions in the DSS-treated mice and inflammatory bowel disease patients.	dss	79-82	wingless-type MMTV integration site family, member 5A	Mus musculus	0-5
25942394-7	2015	RESULTS: According to the 7th edition of the pathological N classification, the 3-year disease-specific survival (DSS) rates for patients with pN1, pN2, and pN3 disease are 89.6%, 65.9%, and 33.6%, respectively (P(N1-N2)=0.030, P(N2-N3)&lt;0.001, P&lt;0.001).	dss	114-117	serpin family E member 2	Homo sapiens	143-146
25942394-7	2015	RESULTS: According to the 7th edition of the pathological N classification, the 3-year disease-specific survival (DSS) rates for patients with pN1, pN2, and pN3 disease are 89.6%, 65.9%, and 33.6%, respectively (P(N1-N2)=0.030, P(N2-N3)&lt;0.001, P&lt;0.001).	dss	114-117	amyloid beta precursor protein	Homo sapiens	148-151
25942394-7	2015	RESULTS: According to the 7th edition of the pathological N classification, the 3-year disease-specific survival (DSS) rates for patients with pN1, pN2, and pN3 disease are 89.6%, 65.9%, and 33.6%, respectively (P(N1-N2)=0.030, P(N2-N3)&lt;0.001, P&lt;0.001).	dss	114-117	sodium voltage-gated channel alpha subunit 10	Homo sapiens	157-160
25942394-8	2015	Under the modified pathological N category criteria, the 3-year DSS rates for pN1, pN2, and pN3 patients were 90.7%, 60.5%, and 31.4%, respectively (P(N1-N2)=0.005, P(N2-N3)=0.004, P&lt;0.001).	dss	64-67	serpin family E member 2	Homo sapiens	78-81
25942394-8	2015	Under the modified pathological N category criteria, the 3-year DSS rates for pN1, pN2, and pN3 patients were 90.7%, 60.5%, and 31.4%, respectively (P(N1-N2)=0.005, P(N2-N3)=0.004, P&lt;0.001).	dss	64-67	amyloid beta precursor protein	Homo sapiens	83-86
25942394-8	2015	Under the modified pathological N category criteria, the 3-year DSS rates for pN1, pN2, and pN3 patients were 90.7%, 60.5%, and 31.4%, respectively (P(N1-N2)=0.005, P(N2-N3)=0.004, P&lt;0.001).	dss	64-67	sodium voltage-gated channel alpha subunit 10	Homo sapiens	92-95
25918247-2	2015	Here, we show in a murine model of dextran sodium sulfate (DSS)-induced colitis that IRF9 deficiency protects animals, whereas the combined loss of IFN-I and IFN-III receptors worsens their condition.	dss	59-62	interferon regulatory factor 9	Mus musculus	85-89
25926411-7	2015	Consistently, mRNA levels of chemokine (C-C motif) ligand 5 in the colon were reduced in both P-SYN and T-SYN mice compared with the DSS group (51%, P &lt; 0.05 and 72%, P &lt; 0.001, respectively).	dss	133-136	chemokine (C-C motif) ligand 5	Mus musculus	29-59
25915426-7	2015	OGA(+/-) mice have higher susceptibility to DSS-induced colitis than OGA(+/+) mice.	dss	44-47	O-GlcNAcase	Mus musculus	0-3
26175852-6	2015	The result of RAP2A expression was further correlated with clinicopathological variables, disease-specific survival (DSS), distant metastasis-free survival (DMeFS), and local recurrence-free survival (LRFS).	dss	117-120	RAP2A, member of RAS oncogene family	Homo sapiens	14-19
26175852-8	2015	In univariate analysis, high expression of RAP2A served as a significant prognostic factor for inferior DSS (P &lt; 0.0001), DMeFS (P &lt; 0.0001), and LRFS (P &lt; 0.0001).	dss	104-107	RAP2A, member of RAS oncogene family	Homo sapiens	43-48
26175852-9	2015	In multivariate analysis, RAP2A overexpression still independently predicted worse DSS (hazard ratio [HR] = 2.976, P &lt; 0.001), DMeFS (HR = 4.233, P &lt; 0.001), and LRFS (HR = 4.156, P &lt; 0.001).	dss	83-86	RAP2A, member of RAS oncogene family	Homo sapiens	26-31
25998509-5	2015	The association between Piwil 2 expression and disease-specific (DSS) or progression-free survival (PFS) was calculated using Kaplan Meier analyses and univariate/multivariate Cox"s regression hazard models.In a multivariate Cox"s regression, Piwil 2 expression, either in the cytoplasm or the nucleus, was significantly associated with DSS and PFS.	dss	65-68	piwi like RNA-mediated gene silencing 2	Homo sapiens	24-31
25968904-2	2015	Here we report that the non-muscle-myosin-II (NMII) heavy chain Myh9 accumulates at epithelial injury sites in mice distal colon treated with dextran sulphate sodium (DSS).	dss	167-170	myosin, heavy polypeptide 9, non-muscle	Mus musculus	64-68
25968904-3	2015	Gut-epithelium-specific Myh9 monoallelic deletion alleviates DSS-induced colonic crypt damage and acute colitis.	dss	61-64	myosin, heavy polypeptide 9, non-muscle	Mus musculus	24-28
25998509-5	2015	The association between Piwil 2 expression and disease-specific (DSS) or progression-free survival (PFS) was calculated using Kaplan Meier analyses and univariate/multivariate Cox"s regression hazard models.In a multivariate Cox"s regression, Piwil 2 expression, either in the cytoplasm or the nucleus, was significantly associated with DSS and PFS.	dss	337-340	piwi like RNA-mediated gene silencing 2	Homo sapiens	24-31
25998509-7	2015	Likewise,, absent nuclear Piwil 2 immunoreactivity was associated with poor DSS and tumor progression (RR=2.3; P=0.023 and RR=2.2; P=0.022).	dss	76-79	piwi like RNA-mediated gene silencing 2	Homo sapiens	26-33
25998509-10	2015	In summary, a combination of weak cytoplasmic and absent nuclear expression of Piwil 2 is significantly associated with an increased risk of DSS and tumor progression.	dss	141-144	piwi like RNA-mediated gene silencing 2	Homo sapiens	79-86
25412653-7	2015	Negative SIP1 immunoreactivity correlated significantly with better disease-specific survival (DSS) and better overall survival (OS) (p=0.012 and p=0.003 for epithelial reactivity, p=0.018 and p=0.003 for stromal reactivity, respectively).	dss	95-98	zinc finger E-box binding homeobox 2	Homo sapiens	9-13
25412653-9	2015	Co-expression of SNAI1, TWIST, and SIP1 in tumor epithelium predicted even shorter DSS than SIP1 expression alone (p&lt;0.001) in the present study cohort.	dss	83-86	snail family transcriptional repressor 1	Homo sapiens	17-22
25412653-9	2015	Co-expression of SNAI1, TWIST, and SIP1 in tumor epithelium predicted even shorter DSS than SIP1 expression alone (p&lt;0.001) in the present study cohort.	dss	83-86	twist family bHLH transcription factor 1	Homo sapiens	24-29
25412653-9	2015	Co-expression of SNAI1, TWIST, and SIP1 in tumor epithelium predicted even shorter DSS than SIP1 expression alone (p&lt;0.001) in the present study cohort.	dss	83-86	zinc finger E-box binding homeobox 2	Homo sapiens	35-39
25751740-0	2015	Recombinant human MFG-E8 ameliorates colon damage in DSS- and TNBS-induced colitis in mice.	dss	53-56	milk fat globule EGF and factor V/VIII domain containing	Homo sapiens	18-24
25269705-3	2015	We found that Trpm8(-/-) mice were hypersusceptible to dextran sodium sulfate (DSS)-induced colitis, and that Trpm8(-/-) CD11c+ DCs (dendritic cells) showed hyperinflammatory responses to toll-like receptor (TLR) stimulation.	dss	79-82	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	14-19
25269705-5	2015	The DSS phenotype of CGRP receptor-deficient mice could be adoptively transferred to wild-type (WT) mice, suggesting that CGRP suppresses the colitogenic activity of bone marrow-derived cells.	dss	4-7	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	21-25
25269705-5	2015	The DSS phenotype of CGRP receptor-deficient mice could be adoptively transferred to wild-type (WT) mice, suggesting that CGRP suppresses the colitogenic activity of bone marrow-derived cells.	dss	4-7	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	122-126
25269705-7	2015	Furthermore, neuronal CGRP contents were increased in colons from naive and DSS-treated Trpm8(-/-) mice, suggesting deficient CGRP release in the absence of TRPM8 triggering.	dss	76-79	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	22-26
25269705-7	2015	Furthermore, neuronal CGRP contents were increased in colons from naive and DSS-treated Trpm8(-/-) mice, suggesting deficient CGRP release in the absence of TRPM8 triggering.	dss	76-79	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	88-93
25269705-7	2015	Furthermore, neuronal CGRP contents were increased in colons from naive and DSS-treated Trpm8(-/-) mice, suggesting deficient CGRP release in the absence of TRPM8 triggering.	dss	76-79	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	126-130
26064439-6	2015	CDCA5 expression was further correlated with clinicopathological features and disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	105-108	cell division cycle associated 5	Homo sapiens	0-5
25897964-4	2015	This study was to evaluate the effects of SBS on azoxymethane (AOM) and dextran sodium sulfate (DSS) induced colitis associated CRC (caCRC) and to analyze the underlying mechanism of SBS in preventing CRC.	dss	96-99	cation channel, sperm associated 3	Mus musculus	133-138
26064439-8	2015	CDCA5 overexpression was predictive for worse DSS and MeFS in univariate and multivariate analysis.	dss	46-49	cell division cycle associated 5	Homo sapiens	0-5
25884558-7	2015	Kaplan-Meier analysis indicated that patients with high intratumoral STYK1 expression had a significantly shorter disease-specific survival (DSS) than those with low expression (p &lt; 0.001).	dss	141-144	serine/threonine/tyrosine kinase 1	Homo sapiens	69-74
25884558-8	2015	Importantly, high levels of STYK1 protein predicted poor DSS for both stage II (p &lt; 0.001) and stage III (p = 0.004) patients.	dss	57-60	serine/threonine/tyrosine kinase 1	Homo sapiens	28-33
25889852-12	2015	In addition, the number of proliferating precursors of neuronal lineage assessed by double Ki67 and DCX staining was significantly diminished in the hippocampus of DSS-treated animals, indicating decreased production of new neurons.	dss	164-167	antigen identified by monoclonal antibody Ki 67	Mus musculus	91-95
25889852-12	2015	In addition, the number of proliferating precursors of neuronal lineage assessed by double Ki67 and DCX staining was significantly diminished in the hippocampus of DSS-treated animals, indicating decreased production of new neurons.	dss	164-167	doublecortin	Mus musculus	100-103
25889852-14	2015	As p21 arrests early neuronal progenitor proliferation, it is likely that p21 induction during acute phase of inflammation resulted in the reduction of hippocampal neurogenesis observed later, on day 29, after the beginning of DSS treatment.	dss	227-230	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	74-77
25885898-9	2015	Survival analysis indicated that patients with lower CA7 expression had a significantly shorter disease-specific survival (DSS) than those with higher CA7 expression.	dss	123-126	carbonic anhydrase 7	Homo sapiens	53-56
25885898-10	2015	Importantly, further stage-based analyses revealed that decreased CA7 expression significantly predicted poor DSS and was an independent adverse prognostic indicator for patients with early stage tumors in both cohorts.	dss	110-113	carbonic anhydrase 7	Homo sapiens	66-69
25619559-9	2015	In p16 positive OPSCC, the 2-year DSS for APF-C was 100% and for TPF-C was 74.6% (CI: 47.4%, 94.6%) (P = 0.0019) and the 2-year OS for APF-C was 94.1% (CI: 65.0%, 99.2%) and for TPF-C was 74.6% (CI: 39.8%, 91.1%) (P = 0.013).	dss	34-37	cyclin dependent kinase inhibitor 2A	Homo sapiens	3-6
25619559-10	2015	In p16 negative HNSCC, the 2-year DSS for APF-C was 91.7% (CI: 67.6%, 99.6%) and for TPF-C was 82.6% (CI: 64.4%, 94.8%) (P = 0.092).	dss	34-37	cyclin dependent kinase inhibitor 2A	Homo sapiens	3-6
25634675-7	2015	RESULTS: E-cadherin deficiency in the adult mouse intestinal epithelium aggravates the clinical and histological features of DSS-induced colitis.	dss	125-128	cadherin 1	Mus musculus	9-19
25634675-8	2015	Upon DSS treatment, mice deficient in E-cadherin lost more weight, were more severely dehydrated, and showed more frequently blood in the feces.	dss	5-8	cadherin 1	Mus musculus	38-48
25638604-3	2015	The aim of this study is to assess the disease specific survival (DSS) in patients with clitoral SCC compared to patients with SCC without clitoral involvement.	dss	66-69	serpin family B member 3	Homo sapiens	97-100
26118126-7	2015	The DSS damaged the colonic tissue, increased MPO activity, lipid peroxidation and NOx levels, reduced the antioxidant enzymes and glutathione and lowered the body weight.	dss	4-7	myeloperoxidase	Mus musculus	46-49
26118126-8	2015	PSE significantly reduced the inflammation of colon and reversed the increase in MPO activity induced by DSS.	dss	105-108	myeloperoxidase	Mus musculus	81-84
25488970-8	2015	Estrogen receptor (ER) status and grade significantly stratified patients with stage I disease with respect to RFS, DSS, and OS.	dss	116-119	estrogen receptor 1	Homo sapiens	0-17
25488970-8	2015	Estrogen receptor (ER) status and grade significantly stratified patients with stage I disease with respect to RFS, DSS, and OS.	dss	116-119	estrogen receptor 1	Homo sapiens	19-21
25690069-7	2015	KEY RESULTS: DSS induced acute colitis with elevated DAI, tissue damage, apoptosis and increased MPO, cytokines, muOR mRNA, and NF-kB.	dss	13-16	myeloperoxidase	Mus musculus	97-100
25638604-8	2015	Kaplan-Meier survival analyses showed worse DSS in patients with a clitoral SCC compared to patients without clitoral involvement.	dss	44-47	serpin family B member 3	Homo sapiens	76-79
25690069-7	2015	KEY RESULTS: DSS induced acute colitis with elevated DAI, tissue damage, apoptosis and increased MPO, cytokines, muOR mRNA, and NF-kB.	dss	13-16	opioid receptor, mu 1	Mus musculus	113-117
25690069-10	2015	CONCLUSIONS &amp; INFERENCES: muOR activation ameliorated the acute but not the delayed phase of DSS colitis by reducing cytokines, likely through activation of the antiapoptotic factor, Bcl-xL, and suppression of NF-kB, a potentiator of inflammation.	dss	97-100	opioid receptor, mu 1	Mus musculus	30-34
25687406-5	2015	We thus treated simple Tgfbr2(DeltaIEC) mice with dextran sodium sulfate (DSS) that causes ulcerative colitis.	dss	74-77	transforming growth factor, beta receptor II	Mus musculus	23-29
25631463-6	2015	Moreover, 6-gingerol significantly suppressed the circulating concentrations of interleukin-1beta and tumor necrosis factor alpha and restored the colonic nitric oxide concentration and myeloperoxidase activity to normal in DSS-treated mice.	dss	224-227	myeloperoxidase	Mus musculus	186-201
25881076-11	2015	The ratio of malignant/tumor in NPC1L1(-/-) mice was significantly lower than in wild-type 20 weeks after AOM-DSS treatment.	dss	110-113	NPC1 like intracellular cholesterol transporter 1	Mus musculus	32-38
25826676-3	2015	Dextran sodium sulfate (DSS)-exposed Blimp-1(cko) mice with a deletion of Blimp-1 in CD103(+) DCs and CD11c(hi) macrophages exhibited severe inflammatory symptoms, pronounced weight loss, high mortality, robust infiltration of neutrophils in epithelial regions of the colon, an increased expression of proinflammatory cytokines and a significant decrease in CD103(+) DCs in the colon compared with DSS exposed wild-type (WT) mice.	dss	24-27	PR domain containing 1, with ZNF domain	Mus musculus	37-44
25826676-3	2015	Dextran sodium sulfate (DSS)-exposed Blimp-1(cko) mice with a deletion of Blimp-1 in CD103(+) DCs and CD11c(hi) macrophages exhibited severe inflammatory symptoms, pronounced weight loss, high mortality, robust infiltration of neutrophils in epithelial regions of the colon, an increased expression of proinflammatory cytokines and a significant decrease in CD103(+) DCs in the colon compared with DSS exposed wild-type (WT) mice.	dss	24-27	PR domain containing 1, with ZNF domain	Mus musculus	74-81
25826676-3	2015	Dextran sodium sulfate (DSS)-exposed Blimp-1(cko) mice with a deletion of Blimp-1 in CD103(+) DCs and CD11c(hi) macrophages exhibited severe inflammatory symptoms, pronounced weight loss, high mortality, robust infiltration of neutrophils in epithelial regions of the colon, an increased expression of proinflammatory cytokines and a significant decrease in CD103(+) DCs in the colon compared with DSS exposed wild-type (WT) mice.	dss	24-27	integrin alpha X	Mus musculus	102-107
25826676-3	2015	Dextran sodium sulfate (DSS)-exposed Blimp-1(cko) mice with a deletion of Blimp-1 in CD103(+) DCs and CD11c(hi) macrophages exhibited severe inflammatory symptoms, pronounced weight loss, high mortality, robust infiltration of neutrophils in epithelial regions of the colon, an increased expression of proinflammatory cytokines and a significant decrease in CD103(+) DCs in the colon compared with DSS exposed wild-type (WT) mice.	dss	398-401	PR domain containing 1, with ZNF domain	Mus musculus	74-81
25825652-4	2015	METHODS: The temporal expression of GHSR/ghrelin was determined in dextran sulphate sodium (DSS) induced colitis in Wt mice.	dss	92-95	growth hormone secretagogue receptor	Mus musculus	36-40
25825652-4	2015	METHODS: The temporal expression of GHSR/ghrelin was determined in dextran sulphate sodium (DSS) induced colitis in Wt mice.	dss	92-95	ghrelin	Mus musculus	41-48
25825652-5	2015	The severity of DSS induced colitis from GHSR(-/-) and WT mice was compared at clinical/pathological levels.	dss	16-19	growth hormone secretagogue receptor	Mus musculus	41-45
25825652-8	2015	This is consistent with the observation of less colonic macrophage infiltration and TLRs expression from DSS-treated GHSR(-/-) mice compared to WT mice (P &lt; 0.05).	dss	105-108	growth hormone secretagogue receptor	Mus musculus	117-121
25825652-11	2015	CONCLUSIONS: GHSR contributes to development of acute DSS-induced colitis, likely via elevated pro-inflammatory cytokines and activation of macrophages.	dss	54-57	growth hormone secretagogue receptor	Mus musculus	13-17
25488476-7	2015	INHBA expression was correlated with clinicopathological features and disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	97-100	inhibin subunit beta A	Homo sapiens	0-5
25488476-10	2015	INHBA overexpression significantly implied inferior DSS (UTUC, P = 0.002; UBUC, P = 0.005) and MeFS (UTUC and UBUC, both P &lt; 0.001) in multivariate analysis.	dss	52-55	inhibin subunit beta A	Homo sapiens	0-5
25293413-2	2015	Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis.	dss	268-271	mannose-binding lectin (protein C) 2	Mus musculus	24-50
25293413-2	2015	Using mice deficient in C1q/mannose-binding lectin (MBL) or C3, we demonstrated an important role for these opsonins and/or the classical pathway C3 convertase in providing protection against mucosal injury and infection in a model of chronic dextran sulphate sodium (DSS)-induced colitis.	dss	268-271	mannose-binding lectin (protein C) 2	Mus musculus	52-55
25214146-8	2015	Kaplan-Meier analysis showed that patients with higher levels of miR-10b had significantly poorer survival than those with lower expression of this miRNA in patients, with a 5-year DSS of 29.5 and 63.8 %, respectively (p = 0.003).	dss	181-184	microRNA 10b	Homo sapiens	65-72
25554966-14	2015	In subgroup analysis, nonkeratinization was associated with improved DSS in those with nonbasaloid and p16-negative tumors and in patients who were smokers.	dss	69-72	cyclin dependent kinase inhibitor 2A	Homo sapiens	103-106
25554966-15	2015	When stratifying patients based on keratinization, p16-status, and smoking status, patients with p16-negative keratinizing tumors who were smokers had the lowest 5-year DSS (26.7%).	dss	169-172	cyclin dependent kinase inhibitor 2A	Homo sapiens	97-100
25631716-10	2015	Aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, and lactate dehydrogenase were significantly lower in DSS-treated rats when watermelon was consumed (P&lt; .05).	dss	130-133	glutamic-oxaloacetic transaminase 2	Rattus norvegicus	0-26
25733301-16	2015	High CD8 density was associated with favorable OS (P = .02) and DSS (P = .02).	dss	64-67	CD8a molecule	Homo sapiens	5-8
25733301-19	2015	CONCLUSION: High intratumoral CD8+ T cell density is associated with better OS and DSS in invasive urothelial carcinoma of the bladder.	dss	83-86	CD8a molecule	Homo sapiens	30-33
25687406-10	2015	We further found that regeneration was impaired in Tgfbr2(DeltaIEC) mice for intestinal mucosa damaged by DSS treatment or X-ray irradiation, resulting in the expansion of undifferentiated epithelial cell population.	dss	106-109	transforming growth factor, beta receptor II	Mus musculus	51-57
25601921-3	2015	The purpose of this study was to investigate the protective effects of pBD2 on mucosal injury and the disruption of the epithelial barrier during the pathological process of dextran sodium sulfate (DSS)-induced colitis.	dss	198-201	peak bone density 2	Mus musculus	71-75
25601921-4	2015	The effects and mechanism of pBD2 were evaluated both using a DSS-induced C57BL/6 mouse model and, in vitro, using Caco-2 and RAW264.7 cells.	dss	62-65	peak bone density 2	Mus musculus	29-33
25601921-5	2015	DSS-induced colitis was characterized by higher disease activity index, shortened colon length, elevated activities of myeloperoxidase and eosinophil peroxidase, histologic evidence of inflammation, and increased expression levels of TNF-alpha, IL-6, and IL-8.	dss	0-3	myeloperoxidase	Mus musculus	119-134
25601921-5	2015	DSS-induced colitis was characterized by higher disease activity index, shortened colon length, elevated activities of myeloperoxidase and eosinophil peroxidase, histologic evidence of inflammation, and increased expression levels of TNF-alpha, IL-6, and IL-8.	dss	0-3	eosinophil peroxidase	Mus musculus	139-160
25601921-5	2015	DSS-induced colitis was characterized by higher disease activity index, shortened colon length, elevated activities of myeloperoxidase and eosinophil peroxidase, histologic evidence of inflammation, and increased expression levels of TNF-alpha, IL-6, and IL-8.	dss	0-3	tumor necrosis factor	Mus musculus	234-243
25601921-5	2015	DSS-induced colitis was characterized by higher disease activity index, shortened colon length, elevated activities of myeloperoxidase and eosinophil peroxidase, histologic evidence of inflammation, and increased expression levels of TNF-alpha, IL-6, and IL-8.	dss	0-3	interleukin 6	Mus musculus	245-249
25601921-5	2015	DSS-induced colitis was characterized by higher disease activity index, shortened colon length, elevated activities of myeloperoxidase and eosinophil peroxidase, histologic evidence of inflammation, and increased expression levels of TNF-alpha, IL-6, and IL-8.	dss	0-3	chemokine (C-X-C motif) ligand 15	Mus musculus	255-259
25601921-6	2015	pBD2 increased the expression of zonula occludens-1, zonula occludens-2, claudin-1, mucin-1, and mucin-2 mRNA and proteins, and it decreased permeability to FITC-D, as well as apoptosis, in DSS-treated mice.	dss	190-193	peak bone density 2	Mus musculus	0-4
25601921-9	2015	The effects of pBD2 appeared to be through upregulation of the expression of genes associated with tight junctions and mucins, and by suppressing DSS-induced increases in inflammation, inducible NO synthase, cyclooxygenase-2, and apoptosis.	dss	146-149	peak bone density 2	Mus musculus	15-19
25601921-10	2015	These results show that pBD2 improves DSS-induced changes in mucosal lesions and paracellular permeability, possibly by affecting the activation of NF-kappaB signaling.	dss	38-41	peak bone density 2	Mus musculus	24-28
25377781-6	2015	DSS induced a rapid activation of c-Jun N-terminal kinase (JNK), and the inhibition or knockdown of JNK2 attenuated DSS-induced tight junction disruption and barrier dysfunction.	dss	0-3	mitogen-activated protein kinase 8	Homo sapiens	34-57
25377781-6	2015	DSS induced a rapid activation of c-Jun N-terminal kinase (JNK), and the inhibition or knockdown of JNK2 attenuated DSS-induced tight junction disruption and barrier dysfunction.	dss	0-3	mitogen-activated protein kinase 8	Homo sapiens	59-62
25377781-6	2015	DSS induced a rapid activation of c-Jun N-terminal kinase (JNK), and the inhibition or knockdown of JNK2 attenuated DSS-induced tight junction disruption and barrier dysfunction.	dss	0-3	mitogen-activated protein kinase 9	Homo sapiens	100-104
25377781-6	2015	DSS induced a rapid activation of c-Jun N-terminal kinase (JNK), and the inhibition or knockdown of JNK2 attenuated DSS-induced tight junction disruption and barrier dysfunction.	dss	116-119	mitogen-activated protein kinase 8	Homo sapiens	34-57
25377781-6	2015	DSS induced a rapid activation of c-Jun N-terminal kinase (JNK), and the inhibition or knockdown of JNK2 attenuated DSS-induced tight junction disruption and barrier dysfunction.	dss	116-119	mitogen-activated protein kinase 8	Homo sapiens	59-62
25377781-6	2015	DSS induced a rapid activation of c-Jun N-terminal kinase (JNK), and the inhibition or knockdown of JNK2 attenuated DSS-induced tight junction disruption and barrier dysfunction.	dss	116-119	mitogen-activated protein kinase 9	Homo sapiens	100-104
25377781-7	2015	In mice, DSS administration for 4 days caused redistribution of tight junction and adherens junction proteins from the epithelial junctions, which was blocked by JNK inhibitor.	dss	9-12	mitogen-activated protein kinase 8	Mus musculus	162-165
25377781-8	2015	In Caco-2 cell monolayers, DSS increased intracellular Ca(2+) concentration, and depletion of intracellular Ca(2+) by 1,2-bis-(o-aminophenoxy)ethane-N,N,N",N"-tetra-acetic acid tetrakis(acetoxymethyl ester) (BAPTA/AM) or thapsigargin attenuated DSS-induced JNK activation, tight junction disruption and barrier dysfunction.	dss	27-30	mitogen-activated protein kinase 8	Homo sapiens	257-260
25377781-9	2015	Knockdown of apoptosis signal-regulated kinase 1 (Ask1) or MKK7 blocked DSS-induced tight junction disruption and barrier dysfunction.	dss	72-75	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	13-48
25377781-9	2015	Knockdown of apoptosis signal-regulated kinase 1 (Ask1) or MKK7 blocked DSS-induced tight junction disruption and barrier dysfunction.	dss	72-75	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	50-54
25377781-9	2015	Knockdown of apoptosis signal-regulated kinase 1 (Ask1) or MKK7 blocked DSS-induced tight junction disruption and barrier dysfunction.	dss	72-75	mitogen-activated protein kinase kinase 7	Homo sapiens	59-63
25377781-10	2015	DSS activated c-Src by a Ca2+ and JNK-dependent mechanism.	dss	0-3	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	14-19
25377781-10	2015	DSS activated c-Src by a Ca2+ and JNK-dependent mechanism.	dss	0-3	mitogen-activated protein kinase 8	Homo sapiens	34-37
25377781-11	2015	Inhibition of Src kinase activity or knockdown of c-Src blocked DSS-induced tight junction disruption and barrier dysfunction.	dss	64-67	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	50-55
25377781-12	2015	DSS increased tyrosine phosphorylation of occludin, zonula occludens-1 (ZO-1), E-cadherin and beta-catenin.	dss	0-3	occludin	Homo sapiens	42-50
25377781-12	2015	DSS increased tyrosine phosphorylation of occludin, zonula occludens-1 (ZO-1), E-cadherin and beta-catenin.	dss	0-3	tight junction protein 1	Homo sapiens	52-70
25377781-12	2015	DSS increased tyrosine phosphorylation of occludin, zonula occludens-1 (ZO-1), E-cadherin and beta-catenin.	dss	0-3	tight junction protein 1	Homo sapiens	72-76
25377781-12	2015	DSS increased tyrosine phosphorylation of occludin, zonula occludens-1 (ZO-1), E-cadherin and beta-catenin.	dss	0-3	cadherin 1	Homo sapiens	79-89
25377781-12	2015	DSS increased tyrosine phosphorylation of occludin, zonula occludens-1 (ZO-1), E-cadherin and beta-catenin.	dss	0-3	catenin beta 1	Homo sapiens	94-106
25377781-15	2015	The present study demonstrates that Ca(2+)/Ask1/MKK7/JNK2/cSrc signalling cascade mediates DSS-induced tight junction disruption and barrier dysfunction.	dss	91-94	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	43-47
25377781-15	2015	The present study demonstrates that Ca(2+)/Ask1/MKK7/JNK2/cSrc signalling cascade mediates DSS-induced tight junction disruption and barrier dysfunction.	dss	91-94	mitogen-activated protein kinase kinase 7	Homo sapiens	48-52
25377781-15	2015	The present study demonstrates that Ca(2+)/Ask1/MKK7/JNK2/cSrc signalling cascade mediates DSS-induced tight junction disruption and barrier dysfunction.	dss	91-94	mitogen-activated protein kinase 9	Homo sapiens	53-57
25377781-15	2015	The present study demonstrates that Ca(2+)/Ask1/MKK7/JNK2/cSrc signalling cascade mediates DSS-induced tight junction disruption and barrier dysfunction.	dss	91-94	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	58-62
25172696-6	2015	Furthermore, increases in the mRNA expression of colonic macrophage inflammatory protein 2 and IL-1beta, which were induced by DSS, were significantly suppressed by CHA supplementation.	dss	127-130	interleukin 1 beta	Homo sapiens	95-103
25371082-4	2015	High Tfh cell counts and levels of IL-21 were observed in UC patients and WT mice with DSS-induced colitis.	dss	87-90	interleukin 21	Homo sapiens	35-40
25371082-7	2015	In addition, neutralization of IL-21 in DSS-administered WT mice using anti-IL-21 reduced the number of Tfh cells and the level of mucosal damage.	dss	40-43	interleukin 21	Mus musculus	31-36
25371082-7	2015	In addition, neutralization of IL-21 in DSS-administered WT mice using anti-IL-21 reduced the number of Tfh cells and the level of mucosal damage.	dss	40-43	interleukin 21	Mus musculus	76-81
25574091-12	2015	Similarly, in the DSS-induced colitis mouse model, IECs showed upregulated expression of DC-SIGN, CD80, CD86 and MHC, and DC-SIGN expression was positively correlated with disease activity (r = 0.62: P &lt; 0.01).	dss	18-21	CD209a antigen	Mus musculus	89-96
25714809-8	2015	Our univariate and multivariate analysis also showed that higher ULK1 expression predicted inferior disease-specific survival (DSS) (P&lt;0.05).	dss	127-130	unc-51 like autophagy activating kinase 1	Homo sapiens	65-69
25714809-9	2015	Consequently, a new clinicopathologic prognostic model with 3 poor prognostic factors (ie, ULK1 expression, overall clinical stage and therapeutic response) could significantly stratify risk (low, intermediate and high) for DSS in NPC patients (P&lt;0.001).	dss	224-227	unc-51 like autophagy activating kinase 1	Homo sapiens	91-95
25964862-11	2014	Tumors with a high expression of IL-6R displayed low mature myeloid cell infiltration and a longer disease-specific survival (DSS), especially in late stage tumors.	dss	126-129	interleukin 6 receptor	Homo sapiens	33-38
25964862-13	2014	In contrast, tumors with high epithelial IL-6 expression displayed a dense infiltration of mature myeloid cells and were correlated with a shorter DSS.	dss	147-150	interleukin 6	Homo sapiens	41-45
25574091-12	2015	Similarly, in the DSS-induced colitis mouse model, IECs showed upregulated expression of DC-SIGN, CD80, CD86 and MHC, and DC-SIGN expression was positively correlated with disease activity (r = 0.62: P &lt; 0.01).	dss	18-21	CD80 antigen	Mus musculus	98-102
25574091-12	2015	Similarly, in the DSS-induced colitis mouse model, IECs showed upregulated expression of DC-SIGN, CD80, CD86 and MHC, and DC-SIGN expression was positively correlated with disease activity (r = 0.62: P &lt; 0.01).	dss	18-21	CD86 antigen	Mus musculus	104-108
25574091-12	2015	Similarly, in the DSS-induced colitis mouse model, IECs showed upregulated expression of DC-SIGN, CD80, CD86 and MHC, and DC-SIGN expression was positively correlated with disease activity (r = 0.62: P &lt; 0.01).	dss	18-21	CD209a antigen	Mus musculus	122-129
25574091-15	2015	However, DC-SIGN expression and T cell differentiation were suppressed following treatment of mice with DSS-induced colitis with PsL-EGFmAb.	dss	104-107	CD209a antigen	Mus musculus	9-16
25574091-16	2015	The proliferation cycles of CD4(+) T cells from mice with DSS-induced colitis appeared as five cycles, which was more than in the control and treated groups.	dss	58-61	CD4 antigen	Mus musculus	28-31
25871810-9	2015	In addition, LC3 immunostaining remained an independent factor impacting OS (p = 0.028) and DSS (p = 0.020) after multivariate analysis.	dss	92-95	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	13-16
25557837-3	2015	The expression of LBH in biopsies of 40 consecutive NPC patients devoid of initial distant metastasis and treated according to consistent guidelines was also analyzed, and we found the LBH expression level was correlated with some of clinicopathological features, disease-specific survival (DSS), distant metastasis-free survival (DMFS).	dss	291-294	LBH regulator of WNT signaling pathway	Homo sapiens	185-188
26481465-6	2015	The Cox proportional hazards model was used to assess the correlation of miR-21 and miR-375 with disease-specific survival (DSS) and overall survival (OS).	dss	124-127	microRNA 21	Homo sapiens	73-79
26481465-8	2015	RESULTS: In ESCC, patients with miR-21 expression levels above median showed a trend towards poorer DSS and OS.	dss	100-103	microRNA 21	Homo sapiens	32-38
26481465-9	2015	When dividing miR-21 expression by tertiles, high levels of miR-21 significantly correlated with shortened DSS [HR 1.76 (95% CI 1.05-2.97) but not OS.	dss	107-110	microRNA 21	Homo sapiens	60-66
26481465-10	2015	Similarly for EAC, a significant association between miR-21 expression above median and DSS was observed [HR 3.37 (95% CI 1.41-8.05)], in addition to a trend towards poorer OS for patients with miR-21 expression above median.	dss	88-91	microRNA 21	Homo sapiens	53-59
26481465-11	2015	Multivariate analyses identified miR-21 as an independent prognostic marker for DSS in EAC [HR 3.52 (95% CI 1.06-11.69)].	dss	80-83	microRNA 21	Homo sapiens	33-39
26481465-14	2015	CONCLUSION: In this study, miR-21 was identified as an independent prognostic biomarker for DSS in patients with EAC whereas miR-21 failed to show independent prognostic significance in ESCC.	dss	92-95	microRNA 21	Homo sapiens	27-33
25388059-7	2015	RESULTS: Multivariate analyses confirmed a better prognosis for SLN-negative patients compared with patients in the observation group (DSS hazard ratio [HR] 0.62, p = 0.03; DFI HR 0.47, p &lt; 0.001).	dss	135-138	sarcolipin	Homo sapiens	64-67
26202676-3	2015	We, therefore, investigated the impact of gal-3 on dextran sodium sulfate (DSS)-induced colitis in a mouse model.	dss	75-78	lectin, galactose binding, soluble 3	Mus musculus	42-47
26202676-5	2015	Acute and chronic DSS colitis was induced by 3% DSS in drinking water in female Balb/c mice weighing 20-22 g. Recombinant gal-3 was expressed by the pET vector system and used for a 5-day treatment in different concentrations intraperitoneally.	dss	18-21	lectin, galactose binding, soluble 3	Mus musculus	122-127
26202676-9	2015	Acute DSS-induced colitis was ameliorated by gal-3 treatment as indicated by increased colonic length and reduced weight loss compared to that of controls.	dss	6-9	lectin, galactose binding, soluble 3	Mus musculus	45-50
25312437-7	2015	In DSS rats, Galphai2 downregulation exacerbated salt-sensitive hypertension via a renal nerve-dependent mechanism.	dss	3-6	G protein subunit alpha i2	Rattus norvegicus	13-21
25312437-8	2015	Congenic-8 DSS rats exhibited sodium-evoked paraventricular nucleus-specific Galphai2-protein upregulation and attenuated hypertension, sodium retention, and global sympathoexcitation compared with DSS rats.	dss	11-14	G protein subunit alpha i2	Rattus norvegicus	77-85
26448758-0	2015	Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model.	dss	99-102	hyaluronan synthase 3	Mus musculus	0-21
24283746-4	2015	RESULTS: mRNA of hBD2 was significantly reduced in irradiated 3% NaCl, 30% NaCl and 30% DSS soaked PEM when compared with non-irradiated PEM.	dss	88-91	defensin beta 4A	Homo sapiens	17-21
24283746-5	2015	ELISA for hBD2 revealed significantly reduced protein expression in irradiated 3% NaCl, 30% NaCl and 30% DSS soaked PEM when compared with non-irradiated PEM.	dss	105-108	defensin beta 4A	Homo sapiens	10-14
24283746-6	2015	Compared with irradiated controls and 3% NaCl soaked and irradiated PEM, BPT using 30% NaCl and 30% DSS revealed significantly decreased hBD2 protein levels.	dss	100-103	defensin beta 4A	Homo sapiens	137-141
25381265-14	2015	PAF levels in feces were significantly higher in the KO mice after AOM/DSS treatment.	dss	71-74	patchy fur	Mus musculus	0-3
25460828-10	2015	DSS administration caused a reduction in the number of intestinal polyps only in Apc(Min/+):mPGES-1(-/-) mice.	dss	0-3	prostaglandin E synthase	Mus musculus	92-99
25842951-5	2015	RESULTS: Under the effect of DSS, expression of adhesion molecules CD162 and CD11b, as well as phospho-p38 MAPK changed, IL-6 and IL-8 secretion induction took place.	dss	29-32	selectin P ligand	Homo sapiens	67-72
25411361-9	2015	DSS inflammation upregulated the mRNA levels of transient receptor potential ankyrin 1 and TRPV1 channels and downregulated that of Kv1.1 and Kv1.4 channels.	dss	0-3	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
25411361-9	2015	DSS inflammation upregulated the mRNA levels of transient receptor potential ankyrin 1 and TRPV1 channels and downregulated that of Kv1.1 and Kv1.4 channels.	dss	0-3	potassium voltage-gated channel subfamily A member 1	Rattus norvegicus	132-137
25411361-9	2015	DSS inflammation upregulated the mRNA levels of transient receptor potential ankyrin 1 and TRPV1 channels and downregulated that of Kv1.1 and Kv1.4 channels.	dss	0-3	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	142-147
28247863-5	2015	Mucosal damage from colitis induced by dextran sodium sulphate (DSS) and 2,4,6-trinitrobenzenesulfonic acid (TNBS) was scored by colonoscopy and histology in apoA-I transgenic (Tg) and apoA-I knockout (KO) and wild-type (WT) mice.	dss	64-67	apolipoprotein A-I	Mus musculus	158-164
28247863-9	2015	DSS/TNBS-treated apoA-I KO mice displayed increased mucosal damage upon both colonoscopy and histology, increased intestinal MPO activity and mRNA expression of TNF and ICAM as compared with WT and apoA-I Tg mice.	dss	0-3	apolipoprotein A-I	Mus musculus	17-23
28247863-9	2015	DSS/TNBS-treated apoA-I KO mice displayed increased mucosal damage upon both colonoscopy and histology, increased intestinal MPO activity and mRNA expression of TNF and ICAM as compared with WT and apoA-I Tg mice.	dss	0-3	myeloperoxidase	Mus musculus	125-128
28247863-9	2015	DSS/TNBS-treated apoA-I KO mice displayed increased mucosal damage upon both colonoscopy and histology, increased intestinal MPO activity and mRNA expression of TNF and ICAM as compared with WT and apoA-I Tg mice.	dss	0-3	tumor necrosis factor	Mus musculus	161-164
28247863-9	2015	DSS/TNBS-treated apoA-I KO mice displayed increased mucosal damage upon both colonoscopy and histology, increased intestinal MPO activity and mRNA expression of TNF and ICAM as compared with WT and apoA-I Tg mice.	dss	0-3	apolipoprotein A-I	Mus musculus	198-204
28247863-10	2015	In contrast, apoA-I Tg mice showed less severe symptoms monitored by colonoscopy and MPO activity in both the DSS and TNBS colitis models.	dss	110-113	apolipoprotein A-I	Mus musculus	13-19
25519168-9	2014	When using median antigen levels as cut-off points, all three uPA system factors were significant predictors for disease-specific survival (DSS) in univariate Cox"s regression analyses.	dss	140-143	plasminogen activator, urokinase	Homo sapiens	62-65
25519168-10	2014	High levels of uPA and uPAR remained independent predictors for DSS with HR=2.86 (95% CI 1.07-7.67, P=0.037) and HR=4.70 (95% CI 1.51-14.6, P=0.008), respectively, in multivariate Cox"s regression analyses.	dss	64-67	plasminogen activator, urokinase	Homo sapiens	15-18
25519168-10	2014	High levels of uPA and uPAR remained independent predictors for DSS with HR=2.86 (95% CI 1.07-7.67, P=0.037) and HR=4.70 (95% CI 1.51-14.6, P=0.008), respectively, in multivariate Cox"s regression analyses.	dss	64-67	plasminogen activator, urokinase receptor	Homo sapiens	23-27
25519168-11	2014	A combination of high antigen levels of uPA and/or uPAR further improved the prediction of DSS in multivariate analysis (HR=14.5, 95% CI 1.88-111.1, P=0.010).	dss	91-94	plasminogen activator, urokinase	Homo sapiens	40-43
25519168-11	2014	A combination of high antigen levels of uPA and/or uPAR further improved the prediction of DSS in multivariate analysis (HR=14.5, 95% CI 1.88-111.1, P=0.010).	dss	91-94	plasminogen activator, urokinase receptor	Homo sapiens	51-55
25519168-13	2014	CONCLUSIONS: High levels of uPA and uPAR in tumour tissue extracts are associated with a significantly shorter DSS of ccRCC patients without distant metastases.	dss	111-114	plasminogen activator, urokinase	Homo sapiens	28-31
25519168-13	2014	CONCLUSIONS: High levels of uPA and uPAR in tumour tissue extracts are associated with a significantly shorter DSS of ccRCC patients without distant metastases.	dss	111-114	plasminogen activator, urokinase receptor	Homo sapiens	36-40
25842951-5	2015	RESULTS: Under the effect of DSS, expression of adhesion molecules CD162 and CD11b, as well as phospho-p38 MAPK changed, IL-6 and IL-8 secretion induction took place.	dss	29-32	integrin subunit alpha M	Homo sapiens	77-82
25842951-5	2015	RESULTS: Under the effect of DSS, expression of adhesion molecules CD162 and CD11b, as well as phospho-p38 MAPK changed, IL-6 and IL-8 secretion induction took place.	dss	29-32	interleukin 6	Homo sapiens	121-125
25628935-10	2015	Higher expression of BCL6 led to a significantly poorer DSS and DFS and multivariate analysis revealed that BCL6 was an independent risk factor of DSS and DFS.	dss	56-59	BCL6 transcription repressor	Homo sapiens	21-25
25628935-10	2015	Higher expression of BCL6 led to a significantly poorer DSS and DFS and multivariate analysis revealed that BCL6 was an independent risk factor of DSS and DFS.	dss	147-150	BCL6 transcription repressor	Homo sapiens	21-25
25628935-10	2015	Higher expression of BCL6 led to a significantly poorer DSS and DFS and multivariate analysis revealed that BCL6 was an independent risk factor of DSS and DFS.	dss	147-150	BCL6 transcription repressor	Homo sapiens	108-112
25525410-11	2014	Drosha/miR-126 co-expression had a significant negative impact on the disease-specific survival (DSS) rate (P &lt; 0.001).	dss	97-100	drosha ribonuclease III	Homo sapiens	0-6
25525410-11	2014	Drosha/miR-126 co-expression had a significant negative impact on the disease-specific survival (DSS) rate (P &lt; 0.001).	dss	97-100	microRNA 126	Homo sapiens	7-14
25271212-8	2014	In survival analyses, high expression of FGFR2 was significantly associated with shorter local recurrence-free survival (p=0.0001), metastasis-free survival (MeFS; p=0.0003) and disease-specific survival (DSS; p&lt;0.0001).	dss	205-208	fibroblast growth factor receptor 2	Homo sapiens	41-46
25392527-8	2014	CD73(-/-) mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice were, and transfer of CD73(+) B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis.	dss	69-72	5' nucleotidase, ecto	Mus musculus	0-4
25392527-8	2014	CD73(-/-) mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice were, and transfer of CD73(+) B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis.	dss	69-72	5' nucleotidase, ecto	Mus musculus	137-141
25392527-8	2014	CD73(-/-) mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice were, and transfer of CD73(+) B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis.	dss	69-72	5' nucleotidase, ecto	Mus musculus	137-141
25392527-8	2014	CD73(-/-) mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice were, and transfer of CD73(+) B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis.	dss	246-249	5' nucleotidase, ecto	Mus musculus	0-4
25392527-8	2014	CD73(-/-) mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice were, and transfer of CD73(+) B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis.	dss	246-249	5' nucleotidase, ecto	Mus musculus	137-141
25392527-8	2014	CD73(-/-) mice were more susceptible to dextran sulfate sodium salt (DSS)-induced colitis than wild type (WT) mice were, and transfer of CD73(+) B cells ameliorated the severity of colitis, suggesting that B cell CD73/CD39/adenosine can modulate DSS-induced colitis.	dss	246-249	5' nucleotidase, ecto	Mus musculus	137-141
25098704-8	2014	Also, the number of PCNA-positive cells within intact colonic crypts decreased significantly in RPE-fed, DSS-exposed mice compared to control diet-fed, DSS-exposed mice.	dss	105-108	proliferating cell nuclear antigen	Mus musculus	20-24
25098704-8	2014	Also, the number of PCNA-positive cells within intact colonic crypts decreased significantly in RPE-fed, DSS-exposed mice compared to control diet-fed, DSS-exposed mice.	dss	152-155	proliferating cell nuclear antigen	Mus musculus	20-24
25674218-6	2014	METHODS: The expression of miR-29a and Mcl-1, an anti-apoptotic BCL-2 family member, was evaluated in both UC patients and UC mice model induced by dextran sodium sulfate (DSS).	dss	172-175	microRNA 29a	Homo sapiens	27-34
25674218-6	2014	METHODS: The expression of miR-29a and Mcl-1, an anti-apoptotic BCL-2 family member, was evaluated in both UC patients and UC mice model induced by dextran sodium sulfate (DSS).	dss	172-175	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	39-44
25674218-8	2014	RESULTS: In UC patients and DSS-induced UC in mice, the expression of miR-29a and Mcl-1, were up-regulated and down-regulated, respectively.	dss	28-31	microRNA 29a	Mus musculus	70-77
25674218-8	2014	RESULTS: In UC patients and DSS-induced UC in mice, the expression of miR-29a and Mcl-1, were up-regulated and down-regulated, respectively.	dss	28-31	myeloid cell leukemia sequence 1	Mus musculus	82-87
24356810-4	2014	METHODS: Expressions of GRAIL mRNA and protein in CD4+ T cells were investigated in the peripheral blood and mucosal tissues of patients with CD, mice with dextran sodium salt (DSS)-induced colitis, and Il-10-deficient mice.	dss	177-180	ring finger protein 128	Homo sapiens	24-29
24356810-6	2014	GRAIL-overexpressing T cells were intravenously injected in mice with DSS-induced colitis.	dss	70-73	ring finger protein 128	Mus musculus	0-5
24356810-10	2014	GRAIL-expressing T cells expressed regulatory T cell markers and showed suppressive effects in murine DSS-induced colitis.	dss	102-105	ring finger protein 128	Mus musculus	0-5
25271212-9	2014	Notably, high expression of FGFR2 was independently predictive of worse outcomes for MeFS (p=0.002, HR=5.387) and DSS (p=0.004, HR=4.997).	dss	114-117	fibroblast growth factor receptor 2	Homo sapiens	28-33
25155043-7	2014	Of note, high expression of REG4 emerged as an adverse prognosticator for DSS (P = 0.0004), LRFS (P = 0.0009), and MeFS (P = 0.0254).	dss	74-77	regenerating family member 4	Homo sapiens	28-32
25526476-10	2014	Kaplan-Meier analysis indicated that gastric cancer (GC) and colorectal cancer (CRC) patients with higher LSINCT5 expression levels have worse disease-free survival (DFS) and disease-specific survival (DSS) rates.	dss	202-205	long stress-induced non-coding transcript 5	Homo sapiens	106-113
25393577-17	2014	Radiation therapy is associated with improved DSS in SCC but not in ACC.	dss	46-49	serpin family B member 3	Homo sapiens	53-56
25526476-11	2014	Moreover, multivariate analysis revealed that increased expression of LSINCT5 is an independent predictor of DFS and DSS rates in GC patients.	dss	117-120	long stress-induced non-coding transcript 5	Homo sapiens	70-77
25379804-8	2014	Surprisingly, DSS/Candida-treated Btk-/- animals had higher levels of certain pro-inflammatory cytokines and levels of the anti-inflammatory cytokine TGF-beta were reduced compared to wild type.	dss	14-17	Bruton agammaglobulinemia tyrosine kinase	Mus musculus	34-37
24803164-0	2014	The oxysterol receptor LXRbeta protects against DSS- and TNBS-induced colitis in mice.	dss	48-51	nuclear receptor subfamily 1, group H, member 2	Mus musculus	23-30
25124254-2	2014	In this study, we demonstrate that mice deficient in the p110delta catalytic subunit activity of class I phosphatidylinositol 3-kinase (PI3Kp110delta) have increased clinical disease activity and histological damage during dextran sodium sulfate (DSS) induced colitis.	dss	247-250	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Mus musculus	57-66
25124254-5	2014	Importantly, adoptive transfer of IL-4-treated macrophages derived from WT mice, but not those from PI3Kp110delta-deficient mice, protects mice during DSS-induced colitis.	dss	151-154	interleukin 4	Mus musculus	34-38
25124254-7	2014	Taken together, our data demonstrate that arginase I activity is required for M2 macrophages mediated protection during DSS-induced colitis in PI3Kp110delta-deficient mice.	dss	120-123	arginase, liver	Mus musculus	42-52
25193776-6	2014	Furthermore, oral administration of TTTTGCCG ameliorated dextran sodium sulfate (DSS)-induced murine colitis and DSS-induced increased expression of inflammatory factor mRNAs, such as macrophage inflammatory protein (MIP)-2 (CXCL2), iNOS, and COX-2.	dss	113-116	chemokine (C-X-C motif) ligand 2	Mus musculus	184-223
25193776-6	2014	Furthermore, oral administration of TTTTGCCG ameliorated dextran sodium sulfate (DSS)-induced murine colitis and DSS-induced increased expression of inflammatory factor mRNAs, such as macrophage inflammatory protein (MIP)-2 (CXCL2), iNOS, and COX-2.	dss	113-116	chemokine (C-X-C motif) ligand 2	Mus musculus	225-230
25193776-6	2014	Furthermore, oral administration of TTTTGCCG ameliorated dextran sodium sulfate (DSS)-induced murine colitis and DSS-induced increased expression of inflammatory factor mRNAs, such as macrophage inflammatory protein (MIP)-2 (CXCL2), iNOS, and COX-2.	dss	113-116	nitric oxide synthase 2, inducible	Mus musculus	233-237
25193776-6	2014	Furthermore, oral administration of TTTTGCCG ameliorated dextran sodium sulfate (DSS)-induced murine colitis and DSS-induced increased expression of inflammatory factor mRNAs, such as macrophage inflammatory protein (MIP)-2 (CXCL2), iNOS, and COX-2.	dss	113-116	cytochrome c oxidase II, mitochondrial	Mus musculus	243-248
25270284-5	2014	Moreover, patients with low-miR-215 expression showed shorter 5-year disease-specific survival (DSS) than the high-miR-215 expression group (p = 0.007).	dss	96-99	microRNA 215	Homo sapiens	28-35
25270284-6	2014	Multivariate analysis results revealed that miR-215 downexpression was an unfavorable prognostic factor for DSS in addition to tumor size, ER, and lymph node metastasis.	dss	108-111	microRNA 215	Homo sapiens	44-51
24850428-6	2014	Chop overexpression increased the susceptibility toward dextran sodium sulfate (DSS)-induced intestinal inflammation and mucosal tissue injury.	dss	80-83	DNA-damage inducible transcript 3	Mus musculus	0-4
24850431-10	2014	Moreover, DSS-induced inflammasome activation relied on caspase-1, but not caspase-11.	dss	10-13	caspase 1	Mus musculus	56-65
25156814-7	2014	ERG amplitudes were significantly decreased in DSS mice compared to controls, with the amplitudes demonstrating a positive correlation with hematocrit, that is, the lowest ERG amplitudes were found with the most severe cases of anemia.	dss	47-50	ETS transcription factor	Mus musculus	0-3
25156814-7	2014	ERG amplitudes were significantly decreased in DSS mice compared to controls, with the amplitudes demonstrating a positive correlation with hematocrit, that is, the lowest ERG amplitudes were found with the most severe cases of anemia.	dss	47-50	ETS transcription factor	Mus musculus	172-175
25156814-9	2014	Despite the association between anemia and ERG signals in DSS-induced colitis, acute RBC infusion may only partially attenuate the associated retinal dysfunction.	dss	58-61	ETS transcription factor	Mus musculus	43-46
25070294-8	2014	The only prognostically significant mutations occurred in BRAF: median recurrence-free (RFS) and disease-specific survival (DSS) for BRAF mutation patients was 7 months and 16 months, versus 19 months and not reached for BRAF wild-type patients, respectively.	dss	124-127	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	58-62
25099619-8	2014	In survival analyses, CPS1 overexpression was significantly associated with shorter disease-specific survival (DSS) and metastasis-free survival (MeFS).	dss	111-114	carbamoyl-phosphate synthase 1	Homo sapiens	22-26
25367573-5	2014	This DC-specific function of RIPK3 was critical for injury-induced inflammation and tissue repair in response to dextran sodium sulfate (DSS).	dss	137-140	receptor-interacting serine-threonine kinase 3	Mus musculus	29-34
25070294-8	2014	The only prognostically significant mutations occurred in BRAF: median recurrence-free (RFS) and disease-specific survival (DSS) for BRAF mutation patients was 7 months and 16 months, versus 19 months and not reached for BRAF wild-type patients, respectively.	dss	124-127	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	133-137
25070294-8	2014	The only prognostically significant mutations occurred in BRAF: median recurrence-free (RFS) and disease-specific survival (DSS) for BRAF mutation patients was 7 months and 16 months, versus 19 months and not reached for BRAF wild-type patients, respectively.	dss	124-127	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	133-137
25070294-9	2014	Multivariate analysis identified BRAF mutant status and number of positive lymph nodes as the only independent prognostic factors for RFS and DSS.	dss	142-145	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	33-37
25034383-5	2014	A primer set for a DSS group-specific 16S rRNA gene was used to construct another clone library, analysis of which revealed that the uncultured group of sulfate-reducing bacteria, SEEP SRB-1, accounted for nearly half of the obtained sequences.	dss	19-22	scavenger receptor class B member 1	Homo sapiens	185-190
24077781-7	2014	However, after the treatment of DSS, PIR-A/B(high) cDCs appeared and gradually increased from day 5 to day 7, at which time the DSS-induced colitis was terminated.	dss	32-35	paired Ig-like receptor B	Mus musculus	37-44
24077781-7	2014	However, after the treatment of DSS, PIR-A/B(high) cDCs appeared and gradually increased from day 5 to day 7, at which time the DSS-induced colitis was terminated.	dss	128-131	paired Ig-like receptor B	Mus musculus	37-44
24077781-10	2014	The immunoregulatory role of PIR-A/B(high) cDCs was confirmed by the in vivo transfer experiment, showing their therapeutic effect on DSS-induced colitis.	dss	134-137	paired Ig-like receptor B	Mus musculus	29-36
25183423-4	2014	Dextran sulphate sodium (DSS)-induced colitis leads to accumulation of bile acids in inflamed colon tissues via activation of the intestinal peroxisome PPARalpha-UGTs pathway.	dss	25-28	peroxisome proliferator activated receptor alpha	Homo sapiens	152-161
25183423-7	2014	Both knockout of PPARalpha and treatment with recombinant FGF19 markedly attenuate DSS-induced colitis.	dss	83-86	peroxisome proliferator activated receptor alpha	Homo sapiens	17-26
25183423-7	2014	Both knockout of PPARalpha and treatment with recombinant FGF19 markedly attenuate DSS-induced colitis.	dss	83-86	fibroblast growth factor 19	Homo sapiens	58-63
24993179-6	2014	Our results, in agreement with those of previous reports, demonstrated that IL-6 mAbs slightly attenuated DSS-induced colitis during the regeneration phase.	dss	106-109	interleukin 6	Mus musculus	76-80
25225794-5	2014	RESULTS: In univariate analyses;   MCT1 (P = 0.021) and   MCT4 (P = 0.027) expression in cancer cells, and   MCT1 (P = 0.003),   MCT2 (P = 0.006),   MCT3 (P = 0.020) expression in stromal cells correlated significantly with a poor DSS.	dss	231-234	solute carrier family 16 member 1	Homo sapiens	35-39
25225794-5	2014	RESULTS: In univariate analyses;   MCT1 (P = 0.021) and   MCT4 (P = 0.027) expression in cancer cells, and   MCT1 (P = 0.003),   MCT2 (P = 0.006),   MCT3 (P = 0.020) expression in stromal cells correlated significantly with a poor DSS.	dss	231-234	solute carrier family 16 member 3	Homo sapiens	58-62
24814373-10	2014	Moreover, those diets remarkably restored DSS-down-regulated expressions of heme oxygenase-1 and HSP70 in livers and kidneys.	dss	42-45	heme oxygenase 1	Mus musculus	76-92
24814373-10	2014	Moreover, those diets remarkably restored DSS-down-regulated expressions of heme oxygenase-1 and HSP70 in livers and kidneys.	dss	42-45	heat shock protein 1B	Mus musculus	97-102
24992835-6	2014	In this study, we investigated the involvement of NO production in activation of the TLR4/NF-kappaB signaling pathway in mice with DSS-induced colitis.	dss	131-134	toll-like receptor 4	Mus musculus	85-89
24992835-6	2014	In this study, we investigated the involvement of NO production in activation of the TLR4/NF-kappaB signaling pathway in mice with DSS-induced colitis.	dss	131-134	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
24992835-7	2014	The addition of 5% DSS to the drinking water of male ICR mice resulted in increases in TLR4 protein in colon tissue and NF-kappaB p65 subunit in the nuclear fraction on day 3, increases in colonic tumor necrosis factor-alpha on day 4, and increases in P-selectin, intercellular adhesion molecule-1, NO2(-)/NO3(-), and nitrotyrosine in colonic mucosa on day 5.	dss	19-22	toll-like receptor 4	Mus musculus	87-91
24992835-7	2014	The addition of 5% DSS to the drinking water of male ICR mice resulted in increases in TLR4 protein in colon tissue and NF-kappaB p65 subunit in the nuclear fraction on day 3, increases in colonic tumor necrosis factor-alpha on day 4, and increases in P-selectin, intercellular adhesion molecule-1, NO2(-)/NO3(-), and nitrotyrosine in colonic mucosa on day 5.	dss	19-22	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	123-129
24992835-7	2014	The addition of 5% DSS to the drinking water of male ICR mice resulted in increases in TLR4 protein in colon tissue and NF-kappaB p65 subunit in the nuclear fraction on day 3, increases in colonic tumor necrosis factor-alpha on day 4, and increases in P-selectin, intercellular adhesion molecule-1, NO2(-)/NO3(-), and nitrotyrosine in colonic mucosa on day 5.	dss	19-22	NBL1, DAN family BMP antagonist	Mus musculus	306-309
24992835-9	2014	Conversely, a NO-releasing compound, NOC-18, increased TLR4 levels and nuclear translocation of NF-kappaB p65 and exacerbated mucosal damage induced by DSS challenge.	dss	152-155	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-105
24992835-10	2014	These data suggest that increases in TLR4 expression induced by drinking DSS-treated water might be directly or indirectly associated with NO overproduction.	dss	73-76	toll-like receptor 4	Mus musculus	37-41
24993179-7	2014	Il-6r-deficient mice and mice with tissue-specific deletion of the Il-6r in the myeloid cell lineage (LysMCre) with acute and chronic DSS-induced colitis were, however, indistinguishable from wild-type mice.	dss	134-137	interleukin 6 receptor, alpha	Mus musculus	67-72
25146101-5	2014	The results showed that GdCl3 had no macrophage depletion effect in colonic mucosa, but significantly suppressed TNBS and DSS-induced TNFalpha, IL-1beta and IL-6 secretions.	dss	122-125	tumor necrosis factor	Mus musculus	134-142
25146101-5	2014	The results showed that GdCl3 had no macrophage depletion effect in colonic mucosa, but significantly suppressed TNBS and DSS-induced TNFalpha, IL-1beta and IL-6 secretions.	dss	122-125	interleukin 1 beta	Mus musculus	144-152
25146101-5	2014	The results showed that GdCl3 had no macrophage depletion effect in colonic mucosa, but significantly suppressed TNBS and DSS-induced TNFalpha, IL-1beta and IL-6 secretions.	dss	122-125	interleukin 6	Mus musculus	157-161
24876225-6	2014	We found the BAG-1 isoform BAG-1M upregulated threefold in human Caco-2 cells following stimulation with tumor necrosis factor receptor alpha (TNFalpha) to induce a pro-inflammatory response, and up to sixfold in mouse enterocytes following treatment with dextran sodium sulfate (DSS) to induce colitis.	dss	280-283	BAG cochaperone 1	Homo sapiens	13-18
25411629-9	2014	Increased baseline levels of hs-CRP, TNF-alpha and IL-6 were associated with renal impairment and cognitive function, especially DSS tests, respectively.	dss	129-132	tumor necrosis factor	Homo sapiens	37-46
25411629-9	2014	Increased baseline levels of hs-CRP, TNF-alpha and IL-6 were associated with renal impairment and cognitive function, especially DSS tests, respectively.	dss	129-132	interleukin 6	Homo sapiens	51-55
25106058-5	2014	RESULTS: Results obtained showed that not only delivery of the pValac:il-10 plasmid by the invasive strain L. lactis MG1363 FnBPA+, but also by the wild-type strain L. lactis MG1363, was effective at diminishing intestinal inflammation (lower inflammation scores and higher IL-10 levels in the intestinal tissues, accompanied by decrease of IL-6) in the DSS-induced IBD mouse model.	dss	354-357	interleukin 10	Mus musculus	70-75
24894865-9	2014	Moreover, colons from DSS-treated Apc(mNLS/mNLS) mice showed fewer goblet cells and reduced Muc2 expression.	dss	22-25	mucin 2	Mus musculus	92-96
25096552-8	2014	Finally, CD137-deficient mice showed increased intestinal permeability upon dextran sodium sulfate (DSS) treatment as compared to control mice.	dss	100-103	tumor necrosis factor receptor superfamily, member 9	Mus musculus	9-14
25015995-7	2014	We found that the expression of CRHR1 and its endogenous ligands: urocortin and CRH were enhanced in the colon of Crhr1(+/+) mice during treatment with AOM and DSS.	dss	160-163	urocortin	Mus musculus	66-75
25015995-7	2014	We found that the expression of CRHR1 and its endogenous ligands: urocortin and CRH were enhanced in the colon of Crhr1(+/+) mice during treatment with AOM and DSS.	dss	160-163	corticotropin releasing hormone receptor 1	Mus musculus	32-37
25015995-7	2014	We found that the expression of CRHR1 and its endogenous ligands: urocortin and CRH were enhanced in the colon of Crhr1(+/+) mice during treatment with AOM and DSS.	dss	160-163	corticotropin releasing hormone	Mus musculus	32-35
25015995-7	2014	We found that the expression of CRHR1 and its endogenous ligands: urocortin and CRH were enhanced in the colon of Crhr1(+/+) mice during treatment with AOM and DSS.	dss	160-163	corticotropin releasing hormone receptor 1	Mus musculus	114-119
24970616-6	2014	The relationship of each drusen feature and the DSS with CFH rs1061170, ABCA1 rs1883025, and ARMS2 rs10490924 at baseline and after 2.6 years was analyzed using multivariate logistic regression models.	dss	48-51	complement factor H	Homo sapiens	57-60
24970616-10	2014	The progression from low to higher DSS was inversely associated with ABCA1 (OR = 0.54), and the progression from intermediate to high DSS was positively related to CFH rs1061170 (OR = 2.3; p &lt; 0.05 for each).	dss	35-38	ATP binding cassette subfamily A member 1	Homo sapiens	69-74
24970616-10	2014	The progression from low to higher DSS was inversely associated with ABCA1 (OR = 0.54), and the progression from intermediate to high DSS was positively related to CFH rs1061170 (OR = 2.3; p &lt; 0.05 for each).	dss	134-137	complement factor H	Homo sapiens	164-167
24973456-3	2014	We report in this article that a member of the TNF-alpha-induced protein 8 (TNFAIP8) family called TIPE2 (TNFAIP8-like 2) plays a crucial role in regulating commensal bacteria dissemination and inflammatory cell function in experimental colitis induced by dextran sodium sulfate (DSS).	dss	280-283	tumor necrosis factor, alpha-induced protein 8	Mus musculus	47-74
24973456-3	2014	We report in this article that a member of the TNF-alpha-induced protein 8 (TNFAIP8) family called TIPE2 (TNFAIP8-like 2) plays a crucial role in regulating commensal bacteria dissemination and inflammatory cell function in experimental colitis induced by dextran sodium sulfate (DSS).	dss	280-283	tumor necrosis factor, alpha-induced protein 8	Mus musculus	76-83
24973456-3	2014	We report in this article that a member of the TNF-alpha-induced protein 8 (TNFAIP8) family called TIPE2 (TNFAIP8-like 2) plays a crucial role in regulating commensal bacteria dissemination and inflammatory cell function in experimental colitis induced by dextran sodium sulfate (DSS).	dss	280-283	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	99-104
24973456-3	2014	We report in this article that a member of the TNF-alpha-induced protein 8 (TNFAIP8) family called TIPE2 (TNFAIP8-like 2) plays a crucial role in regulating commensal bacteria dissemination and inflammatory cell function in experimental colitis induced by dextran sodium sulfate (DSS).	dss	280-283	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	106-120
24973456-7	2014	Importantly, the ameliorated DSS-induced colitis in TIPE2(-/-) mice also was associated with reduced local dissemination of commensal bacteria and a weaker systemic inflammatory response.	dss	29-32	tumor necrosis factor, alpha-induced protein 8-like 2	Mus musculus	52-57
25177159-7	2014	DSS-induced colitis model also induces changes in Th-1/Th-2 cytokine profile.	dss	0-3	negative elongation factor complex member C/D	Homo sapiens	50-54
24832648-8	2014	TRPM8 immunoreactivity markedly increased in the distal colon mucosa of DSS-induced colitis mice compared with control mice.	dss	72-75	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	0-5
24832648-9	2014	The number of TRPM8 nerve fibers in mucosa of DSS- or 2,4,6-trinitrobenzene sulfonic acid-induced colitis model mice drastically increased compared with control mice.	dss	46-49	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	14-19
24810927-10	2014	In addition, high expression of ANXA1 emerged as an adverse prognosticator for DSS (p &lt; 0.0001), LRFS (p = 0.0001) and MeFS (p = 0.0004).	dss	79-82	annexin A1	Homo sapiens	32-37
24810927-11	2014	Moreover, high expression of ANXA1 also remained independently prognostic of worse DSS (hazard ratio [HR] = 3.998; p = 0.007), LRFS (HR = 3.206; p = 0.028) and MeFS (HR = 3.075; p = 0.017).	dss	83-86	annexin A1	Homo sapiens	29-34
24833092-8	2014	AMACR overexpression was significantly associated with increment of primary tumor status (P = 0.009) and univariately predictive of adverse outcomes for DSS, DMFS, and LRFS.	dss	153-156	alpha-methylacyl-CoA racemase	Homo sapiens	0-5
24833092-9	2014	In the multivariate comparison, AMACR overexpression still remained prognostically independent to portend worse DSS (P = 0.006, hazard ratio = 2.129), DMFS (P = 0.001, hazard ratio = 2.795), and LRFS (P = 0.041, hazard ratio = 2.009), together with advanced American Joint of Cancer Committee (AJCC) stages III-IV.	dss	112-115	alpha-methylacyl-CoA racemase	Homo sapiens	32-37
24916695-5	2014	RESULTS: A three-protein panel including CLIC4, ERp29, and Smac/DIABLO, which was generated from multivariate analysis by excluding clinicopathologic characteristics from the training cohort, distinguished patients with colorectal cancer into very low-, low-, middle-, and high-risk groups with significant differences in five-year DSS probability (88.6%, 63.3%, 30.4%, 11.4%; P &lt; 0.001).	dss	332-335	diablo IAP-binding mitochondrial protein	Homo sapiens	59-63
24720832-0	2014	UNC5B receptor deletion exacerbates DSS-induced colitis in mice by increasing epithelial cell apoptosis.	dss	36-39	unc-5 netrin receptor B	Mus musculus	0-5
24720832-3	2014	We tested the hypothesis that UNC5B receptor is a critical mediator of protective function of netrin-1 in dextran sodium sulfate (DSS)-induced colitis using mice with partial deletion of UNC5B receptor.	dss	130-133	unc-5 netrin receptor B	Mus musculus	30-35
24720832-3	2014	We tested the hypothesis that UNC5B receptor is a critical mediator of protective function of netrin-1 in dextran sodium sulfate (DSS)-induced colitis using mice with partial deletion of UNC5B receptor.	dss	130-133	netrin 1	Mus musculus	94-102
24720832-7	2014	These changes were exacerbated in heterozygous UNC5B knockout mice treated with DSS.	dss	80-83	unc-5 netrin receptor B	Mus musculus	47-52
24720832-10	2014	Overexpression of UNC5B human colon epithelial cells suppressed DSS-induced apoptosis and caspase-3 activity.	dss	64-67	unc-5 netrin receptor B	Homo sapiens	18-23
24720832-11	2014	Moreover, DSS induced large amount of netrin-1 and shRNA mediated knockdown of netrin-1 induction exacerbated DSS-induced epithelial cell apoptosis.	dss	10-13	netrin 1	Mus musculus	38-46
24720832-11	2014	Moreover, DSS induced large amount of netrin-1 and shRNA mediated knockdown of netrin-1 induction exacerbated DSS-induced epithelial cell apoptosis.	dss	10-13	netrin 1	Mus musculus	79-87
24720832-11	2014	Moreover, DSS induced large amount of netrin-1 and shRNA mediated knockdown of netrin-1 induction exacerbated DSS-induced epithelial cell apoptosis.	dss	110-113	netrin 1	Mus musculus	79-87
24817032-6	2014	Resveratrol treatment dramatically reversed the effects of DSS on the numbers of specific inflammatory CD4(+) T cells, CD8(+) T cells, B cells, natural killer T cells, and myeloid-derived suppressor cells in mesenteric lymph nodes.	dss	59-62	CD4 antigen	Mus musculus	103-106
24793451-8	2014	BALB/c mice exhibited higher angiogenic gene expression in control and DSS groups compared with other strains, specifically platelet-derived growth factor, angiopoietin-1, angiopoietin-1 (Ang-2), vascular endothelial growth factor receptor, and PDGF receptor.	dss	71-74	angiopoietin 1	Mus musculus	156-170
24728493-5	2014	RESULTS: Univariable Cox regression analysis showed that overexpression of EpCAM is associated with favorable prognosis in terms of progression-free survival (PFS) (p = 0.011) and disease-specific survival (DSS) (p = 0.003).	dss	207-210	epithelial cell adhesion molecule	Homo sapiens	75-80
24793451-8	2014	BALB/c mice exhibited higher angiogenic gene expression in control and DSS groups compared with other strains, specifically platelet-derived growth factor, angiopoietin-1, angiopoietin-1 (Ang-2), vascular endothelial growth factor receptor, and PDGF receptor.	dss	71-74	angiopoietin 1	Mus musculus	172-186
24301657-0	2014	IL-10 modulates DSS-induced colitis through a macrophage-ROS-NO axis.	dss	16-19	interleukin 10	Mus musculus	0-5
24301657-4	2014	Mice with a macrophage-selective deletion of IL-10Ralpha (IL-10Ralpha(Mdel)) developed markedly enhanced dextran sodium sulfate (DSS)-induced colitis that did not significantly differ from disease in IL-10(-/-) or IL-10Ralpha(-/-) mice; no impact of IL-10Ralpha deficiency in other lineages was observed.	dss	129-132	interleukin 10 receptor, alpha	Mus musculus	45-56
24301657-4	2014	Mice with a macrophage-selective deletion of IL-10Ralpha (IL-10Ralpha(Mdel)) developed markedly enhanced dextran sodium sulfate (DSS)-induced colitis that did not significantly differ from disease in IL-10(-/-) or IL-10Ralpha(-/-) mice; no impact of IL-10Ralpha deficiency in other lineages was observed.	dss	129-132	interleukin 10 receptor, alpha	Mus musculus	58-69
24301657-4	2014	Mice with a macrophage-selective deletion of IL-10Ralpha (IL-10Ralpha(Mdel)) developed markedly enhanced dextran sodium sulfate (DSS)-induced colitis that did not significantly differ from disease in IL-10(-/-) or IL-10Ralpha(-/-) mice; no impact of IL-10Ralpha deficiency in other lineages was observed.	dss	129-132	interleukin 10	Mus musculus	45-50
24301657-4	2014	Mice with a macrophage-selective deletion of IL-10Ralpha (IL-10Ralpha(Mdel)) developed markedly enhanced dextran sodium sulfate (DSS)-induced colitis that did not significantly differ from disease in IL-10(-/-) or IL-10Ralpha(-/-) mice; no impact of IL-10Ralpha deficiency in other lineages was observed.	dss	129-132	interleukin 10 receptor, alpha	Mus musculus	58-69
24301657-10	2014	Therefore, the palliative actions of IL-10 in DSS-induced colitis predominantly results from its macrophage-specific effects.	dss	46-49	interleukin 10	Mus musculus	37-42
24940486-7	2014	Patients exhibiting overexpression of FGFR1, FGFR2 or FGFR4 had a significantly poorer disease-specific survival (DSS; P&lt;0.001, P=0.008 and P&lt;0.001, respectively).	dss	114-117	fibroblast growth factor receptor 1	Homo sapiens	38-43
24731292-2	2014	We demonstrated previously that Epimorphin(-/-)(Epim(-/-)) mice are protected, in part, from dextran sodium sulfate (DSS)-induced colitis.	dss	117-120	syntaxin 2	Mus musculus	32-42
24731292-2	2014	We demonstrated previously that Epimorphin(-/-)(Epim(-/-)) mice are protected, in part, from dextran sodium sulfate (DSS)-induced colitis.	dss	117-120	syntaxin 2	Mus musculus	32-36
24731292-9	2014	Epim deletion abrogates IL-6 secretion from colonic myofibroblasts treated with IL-1beta and decreases IL-6 secretion from peritoneal macrophages in a subset of DSS-treated mice.	dss	161-164	syntaxin 2	Mus musculus	0-4
24731292-11	2014	Distribution of Stat3 activation is altered in DSS-treated Epim(-/-) mice.	dss	47-50	signal transducer and activator of transcription 3	Mus musculus	16-21
24731292-11	2014	Distribution of Stat3 activation is altered in DSS-treated Epim(-/-) mice.	dss	47-50	syntaxin 2	Mus musculus	59-63
24731292-12	2014	Our findings support the notion that myofibroblasts modulate IL-6/p-Stat3 signaling in DSS-treated Epim(-/-) mice.	dss	87-90	interleukin 6	Mus musculus	61-65
24731292-12	2014	Our findings support the notion that myofibroblasts modulate IL-6/p-Stat3 signaling in DSS-treated Epim(-/-) mice.	dss	87-90	signal transducer and activator of transcription 3	Mus musculus	68-73
24731292-12	2014	Our findings support the notion that myofibroblasts modulate IL-6/p-Stat3 signaling in DSS-treated Epim(-/-) mice.	dss	87-90	syntaxin 2	Mus musculus	99-103
24940486-7	2014	Patients exhibiting overexpression of FGFR1, FGFR2 or FGFR4 had a significantly poorer disease-specific survival (DSS; P&lt;0.001, P=0.008 and P&lt;0.001, respectively).	dss	114-117	fibroblast growth factor receptor 2	Homo sapiens	45-50
24940486-7	2014	Patients exhibiting overexpression of FGFR1, FGFR2 or FGFR4 had a significantly poorer disease-specific survival (DSS; P&lt;0.001, P=0.008 and P&lt;0.001, respectively).	dss	114-117	fibroblast growth factor receptor 4	Homo sapiens	54-59
24771220-10	2014	Multivariate analysis suggested high CDK4 expression was an independent prognostic indicator of worse DMeFS (p = 0.001, hazard ratio (HR) = 3.226) and DSS (p = 0.037, HR = 1.838).	dss	151-154	cyclin dependent kinase 4	Homo sapiens	37-41
24879442-2	2014	Here, we show that Git2-deficient mice were more susceptible to dextran sodium sulfate (DSS)-induced colitis, Escherichia coli, or endotoxin-shock challenge, and a dramatic increase in proinflammatory cytokines was observed in Git2 knockout mice and macrophages.	dss	88-91	GIT ArfGAP 2	Mus musculus	19-23
28234324-8	2014	In particular, the expression of interferon gamma receptor 2 (Ifngr2) and guanylate-binding proteins (GBPs) was increased by DSS treatment and decreased in LWPC-fed mice.	dss	125-128	interferon gamma receptor 2	Mus musculus	33-60
28234324-8	2014	In particular, the expression of interferon gamma receptor 2 (Ifngr2) and guanylate-binding proteins (GBPs) was increased by DSS treatment and decreased in LWPC-fed mice.	dss	125-128	interferon gamma receptor 2	Mus musculus	62-68
24495471-6	2014	The PBR (200, 500mg/kg/day) was applied into the mouse model of dextran sodium sulfate (DSS)-induced colitis and lipopolysaccharide (LPS)-stimulated mouse macrophage RAW264.7 cells.	dss	88-91	resistance to Paracoccidioides brasiliensis	Mus musculus	4-7
24495471-9	2014	RESULTS: In the mouse model of DSS-induced colitis, PBR ameliorated the pathological characteristics of colitis such as shortening of colon length and improved the disease activity index score.	dss	31-34	resistance to Paracoccidioides brasiliensis	Mus musculus	52-55
24495471-12	2014	Further, PBR treatment reduced the expression of mitogen-activated protein kinases (MAPKs) (e.g., extracellular signal-regulated protein kinase (ERK) and p38) in the mouse model of DSS-induced colitis.	dss	181-184	resistance to Paracoccidioides brasiliensis	Mus musculus	9-12
24495471-12	2014	Further, PBR treatment reduced the expression of mitogen-activated protein kinases (MAPKs) (e.g., extracellular signal-regulated protein kinase (ERK) and p38) in the mouse model of DSS-induced colitis.	dss	181-184	mitogen-activated protein kinase 14	Mus musculus	154-157
24821878-8	2014	In univariable survival analysis, HPV positivity was significantly correlated with improved OS (74% v 52%; P=.036) and DSS (84% v 52%; P=.002), and p16 positivity was significantly correlated with improved OS (76% v 30%; P&lt;.001) and DSS (85% v 30%; P&lt;.001).	dss	236-239	cyclin dependent kinase inhibitor 2A	Homo sapiens	148-151
24821878-9	2014	In multivariable COX analysis that included HPV status, p16 status, sex, T stage, N stage, and treatment, p16 positivity remained an independent prognostic factor for OS (hazard ratio [HR], 0.07; 95% CI, 0.01 to 0.61; P=.016) and DSS (HR, 0.07; 95% CI, 0.01 to 0.53; P=.011).	dss	230-233	cyclin dependent kinase inhibitor 2A	Homo sapiens	106-109
24821878-10	2014	CONCLUSION: p16 positivity is an independent prognostic factor for OS and DSS in patients with AJCC stages I to III carcinoma of the anal canal.	dss	74-77	cyclin dependent kinase inhibitor 2A	Homo sapiens	12-15
24828351-10	2014	Five-year DSS with HPV-positive tumor was 77% compared with 53% with an HPV-negative tumor (p &lt; 0.001), also valid with adjustment for age, gender, and TNM stage, but primarily determined with patients with the specific tumor sites tonsils and base of the tongue with TNM stages T3 or N2.	dss	10-13	teneurin transmembrane protein 1	Homo sapiens	155-158
24687970-12	2014	High-level expression of GATA4 also predicted shorter DSS (HR 3.96, 95% CI 1.45-12.57, P = 0.006).	dss	54-57	GATA binding protein 4	Homo sapiens	25-30
24807684-7	2014	Univariate Cox regression models with respect to OS and DSS showed a significant difference between buccal cancer and nonbuccal cancer.	dss	56-59	cytochrome c oxidase subunit 8A	Homo sapiens	11-14
24845399-9	2014	mPer2(m/m) mice were more resistant to the colonic injury induced by DSS than wild-type mice.	dss	69-72	period circadian clock 2	Mus musculus	0-5
24486481-11	2014	Treating mice with a rodent specific PXR agonist, pregnenolone 16alpha-carbonitrile (PCN), attenuated the intestinal barrier dysfunction observed in the dextran sulphate sodium (DSS) model of experimental colitis, an effect that occurred independent of the known anti-inflammatory effects of PCN.	dss	178-181	nuclear receptor subfamily 1, group I, member 2	Mus musculus	37-40
24885195-8	2014	Moreover, reduced ezrin expression was associated with a significantly reduced 5-year OS in both cohorts (HR = 3.09 95% CI 1.71-5.58 and HR = 2.15(1.51-3.06), and with DSS in cohort II (HR = 2.77, 95% CI 1.78-4.31).	dss	168-171	ezrin	Homo sapiens	18-23
24885002-8	2014	In addition, CNTNAP2 and S100A8 protein expression were correlated with DSS and OS, respectively.	dss	72-75	contactin associated protein 2	Homo sapiens	13-20
24885002-8	2014	In addition, CNTNAP2 and S100A8 protein expression were correlated with DSS and OS, respectively.	dss	72-75	S100 calcium binding protein A8	Homo sapiens	25-31
24646142-6	2014	RESULTS: Patients with NPC who overexpressed galectin-1 in cytoplasm showed more aggressive tumor growth and significantly shorter disease-specific survival (DSS) (p = 0.0037) and distant metastasis-free survival (DMFS) (p = 0.0006) than patients with NPC who did not overexpress galectin-1.	dss	158-161	galectin 1	Homo sapiens	45-55
24833908-4	2014	In the cohort of patients with advanced localized or metastasized ccRCC, high staining of Ki67, p53 and nS predicted shorter DSS (Ki67: HR 1.07, 95% CI 1.02-1.11; p53: HR 1.05, 95% CI 1.01-1.09; nS: HR 1.08, 95% CI 1.02-1.14).	dss	125-128	tumor protein p53	Homo sapiens	96-99
24833908-5	2014	In organ-confined ccRCC, patients with high p21-staining had a longer DSS (HR 0.96, 95% CI 0.92-0.99).	dss	70-73	cyclin dependent kinase inhibitor 1A	Homo sapiens	44-47
24833908-6	2014	In a multivariate model with stepwise backward elimination, tumor size and p21-staining showed a significant association with DSS in patients with "organ-confined" ccRCCs.	dss	126-129	cyclin dependent kinase inhibitor 1A	Homo sapiens	75-78
24373192-9	2014	Slc26a3(-/-) mice were highly susceptible to DSS damage.	dss	45-48	solute carrier family 26, member 3	Mus musculus	0-7
24373192-10	2014	CONCLUSIONS: Deletion of DRA results in severely reduced colonic HCO3 (-) secretory rate, a loss of colonic fluid absorption, a lack of a firmly adherent mucus layer and a severely reduced colonic mucosal resistance to DSS damage.	dss	219-222	solute carrier family 26, member 3	Mus musculus	25-28
24603458-7	2014	In the DSS model of colon epithelial injury, Mal(-/-) mice developed increased inflammation and severity of colitis relative to WT mice.	dss	7-10	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	45-48
24603458-9	2014	Furthermore, in the AOM/DSS model, Mal(-/-) mice had greater incidence of tumors.	dss	24-27	myelin and lymphocyte protein, T cell differentiation protein	Mus musculus	35-38
24715114-4	2014	Acute and chronic treatment with DSS significantly increased SP immunoreactivity in thoracic and lumbosacral spinal cord segments.	dss	33-36	tachykinin 1	Mus musculus	61-63
24646142-7	2014	Multivariate analysis showed that galectin-1 overexpression remained prognostically independent for DSS (p = 0.031, hazard ratio = 1.821), and DMFS (p = 0.005, hazard ratio = 2.417), together with the advanced III-IV stages.	dss	100-103	galectin 1	Homo sapiens	34-44
24108656-8	2014	SCC grading correlated significantly with recurrence rate (P = 0.005), DFS (P = 0.004), and DSS (P = 0.0036).	dss	92-95	serpin family B member 3	Homo sapiens	0-3
24604303-5	2014	In this study, we examined the therapeutic effect of injecting an adenoviral vector encoding the human HGF gene (Ad.HGF) into the hindlimbs of mice with dextran sodium sulfate (DSS)-induced colitis.	dss	177-180	hepatocyte growth factor	Homo sapiens	103-106
24604303-5	2014	In this study, we examined the therapeutic effect of injecting an adenoviral vector encoding the human HGF gene (Ad.HGF) into the hindlimbs of mice with dextran sodium sulfate (DSS)-induced colitis.	dss	177-180	hepatocyte growth factor	Homo sapiens	116-119
24604303-11	2014	Thus, systemically circulating hHGF protein, produced by an adenovirally transduced hHGF gene introduced at distal sites in the limbs, significantly ameliorated DSS-induced colitis by promoting cell proliferation (i.e., regeneration), preventing apoptosis, and immunomodulation.	dss	161-164	hepatocyte growth factor	Homo sapiens	31-35
24604303-11	2014	Thus, systemically circulating hHGF protein, produced by an adenovirally transduced hHGF gene introduced at distal sites in the limbs, significantly ameliorated DSS-induced colitis by promoting cell proliferation (i.e., regeneration), preventing apoptosis, and immunomodulation.	dss	161-164	hepatocyte growth factor	Homo sapiens	84-88
24430661-1	2014	We evaluated the anti-inflammatory activity of mannanase-hydrolyzed copra meal (MNB), including beta-1,4-mannobiose (67.8%), in a dextran sodium sulfate (DSS)-induced porcine model of intestinal inflammation.	dss	154-157	mannosidase beta	Homo sapiens	47-56
24430661-1	2014	We evaluated the anti-inflammatory activity of mannanase-hydrolyzed copra meal (MNB), including beta-1,4-mannobiose (67.8%), in a dextran sodium sulfate (DSS)-induced porcine model of intestinal inflammation.	dss	154-157	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	80-83
24430661-2	2014	In the DSS-positive control (POS) and MNB treatment (MCM) groups, DSS was first administered to piglets via intragastric catheter for 5 days, followed by 5 days administration of saline or MCM.	dss	66-69	dual specificity tyrosine phosphorylation regulated kinase 1A	Homo sapiens	38-41
24966911-3	2014	We aimed to investigate the expression and the role of FBP1 in dextran sodium sulphate (DSS)-induced experimental colitis.	dss	88-91	fructose bisphosphatase 1	Mus musculus	55-59
24766737-9	2014	RESULTS: AOM/DSS-induced caCRC phenotypically resembled human caCRC.	dss	13-16	cation channel sperm associated 3	Homo sapiens	25-30
24766737-9	2014	RESULTS: AOM/DSS-induced caCRC phenotypically resembled human caCRC.	dss	13-16	cation channel sperm associated 3	Homo sapiens	62-67
24262069-12	2014	Ten-year disease-specific survival (DSS) was lower in TCV (96%) and PTC TCF (91%) than in classical PTC (100%; p&lt;0.001).	dss	36-39	hepatocyte nuclear factor 4 alpha	Homo sapiens	72-75
24743300-5	2014	The results showed that DSS-induced colitis was attenuated and Tregs were hyperfunctional in GPx1-/- x Cat-/- mice.	dss	24-27	glutathione peroxidase 1	Mus musculus	93-97
24503767-4	2014	Increased susceptibility of TCRdelta(-/-) mice to dextran sodium sulfate (DSS)-induced colitis is associated with a reduced number of goblet cells.	dss	74-77	T cell receptor delta chain	Mus musculus	28-36
23793223-2	2014	DESIGN: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1alpha or IL-1beta, and in wild-type mice, or in mice with conditional deletion of IL-1alpha in intestinal epithelial cells (IECs).	dss	32-35	interleukin 1 alpha	Mus musculus	94-103
23793223-2	2014	DESIGN: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1alpha or IL-1beta, and in wild-type mice, or in mice with conditional deletion of IL-1alpha in intestinal epithelial cells (IECs).	dss	32-35	interleukin 1 beta	Mus musculus	107-115
23793223-2	2014	DESIGN: Dextran sodium sulfate (DSS) colitis was induced in mice globally deficient in either IL-1alpha or IL-1beta, and in wild-type mice, or in mice with conditional deletion of IL-1alpha in intestinal epithelial cells (IECs).	dss	32-35	interleukin 1 alpha	Mus musculus	180-189
23793223-8	2014	CONCLUSIONS: The role of IL-1alpha and IL-1beta differs in DSS-induced colitis in that IL-1alpha, mainly of colon epithelial cells is inflammatory, whereas IL-1beta, mainly of myeloid cell origin, promotes healing and repair.	dss	59-62	interleukin 1 alpha	Mus musculus	25-34
23793223-8	2014	CONCLUSIONS: The role of IL-1alpha and IL-1beta differs in DSS-induced colitis in that IL-1alpha, mainly of colon epithelial cells is inflammatory, whereas IL-1beta, mainly of myeloid cell origin, promotes healing and repair.	dss	59-62	interleukin 1 beta	Mus musculus	39-47
23793223-8	2014	CONCLUSIONS: The role of IL-1alpha and IL-1beta differs in DSS-induced colitis in that IL-1alpha, mainly of colon epithelial cells is inflammatory, whereas IL-1beta, mainly of myeloid cell origin, promotes healing and repair.	dss	59-62	interleukin 1 alpha	Mus musculus	87-96
23793223-8	2014	CONCLUSIONS: The role of IL-1alpha and IL-1beta differs in DSS-induced colitis in that IL-1alpha, mainly of colon epithelial cells is inflammatory, whereas IL-1beta, mainly of myeloid cell origin, promotes healing and repair.	dss	59-62	interleukin 1 beta	Mus musculus	156-164
24262069-17	2014	PTC TCF and TCV have similar DSS and distant RFS but poorer outcomes than classical PTC.	dss	29-32	hepatocyte nuclear factor 4 alpha	Homo sapiens	4-7
24913672-2	2014	The present study aimed to investigate the effect of uPA deficiency on the long-term outcome of early life episodes of dextran sodium sulfate (DSS)-induced colitis in mice.	dss	143-146	plasminogen activator, urokinase	Mus musculus	53-56
23546544-8	2014	In the multivariate analysis, high grade tumor, positive lymph node involvement and INF &gt;=b were independent predictors for DSS (p &lt; 0.05).	dss	127-130	cobalamin binding intrinsic factor	Homo sapiens	84-87
24229607-6	2014	The results indicated that DSS treatment resulted in a lower percentage of small-intestinal IEL gammadelta-T cells and higher mRNA expressions of interferon-gamma, TNF-alpha, IL-17, complement 5a receptor and keratinocyte growth factor in IEL gammadelta-T cells.	dss	27-30	interferon gamma	Mus musculus	146-162
24229607-6	2014	The results indicated that DSS treatment resulted in a lower percentage of small-intestinal IEL gammadelta-T cells and higher mRNA expressions of interferon-gamma, TNF-alpha, IL-17, complement 5a receptor and keratinocyte growth factor in IEL gammadelta-T cells.	dss	27-30	tumor necrosis factor	Mus musculus	164-173
24229607-6	2014	The results indicated that DSS treatment resulted in a lower percentage of small-intestinal IEL gammadelta-T cells and higher mRNA expressions of interferon-gamma, TNF-alpha, IL-17, complement 5a receptor and keratinocyte growth factor in IEL gammadelta-T cells.	dss	27-30	interleukin 17A	Mus musculus	175-204
24229607-8	2014	The histological findings indicated that the immunoreactive intensity of the tight junction protein ZO-1 in the small-intestinal mucosa was higher in the DSS-G group than in the DSS-C group.	dss	154-157	tight junction protein 1	Mus musculus	100-104
24229607-8	2014	The histological findings indicated that the immunoreactive intensity of the tight junction protein ZO-1 in the small-intestinal mucosa was higher in the DSS-G group than in the DSS-C group.	dss	178-181	tight junction protein 1	Mus musculus	100-104
24913672-7	2014	One week after DSS treatment, there were typical DSS-induced colitis lesions in both WT and uPA(-/-) mice.	dss	15-18	plasminogen activator, urokinase	Mus musculus	92-95
24913672-7	2014	One week after DSS treatment, there were typical DSS-induced colitis lesions in both WT and uPA(-/-) mice.	dss	49-52	plasminogen activator, urokinase	Mus musculus	92-95
24913675-5	2014	High expression of MMP9 and VEGFA in endothelium and mesothelium and CD in mesothelium was positively associated with poor disease-specific survival (DSS).	dss	150-153	matrix metallopeptidase 9	Homo sapiens	19-23
24913675-5	2014	High expression of MMP9 and VEGFA in endothelium and mesothelium and CD in mesothelium was positively associated with poor disease-specific survival (DSS).	dss	150-153	vascular endothelial growth factor A	Homo sapiens	28-33
24913675-5	2014	High expression of MMP9 and VEGFA in endothelium and mesothelium and CD in mesothelium was positively associated with poor disease-specific survival (DSS).	dss	150-153	cathepsin D	Homo sapiens	69-71
24913675-6	2014	High MMP9 expression in either endothelium or mesothelium and presence of ascites prospectively showed the greatest risk of shorter DSS [hazard ratio (HR)= 6.16, 95% confidence interval (CI) = 1.76-21.6, P = .0045; HR = 11.42, 95% CI = 2.59-50.35, P = .0013; and HR = 6.35, 95% CI = 2.01-20.1, P = .002, respectively].	dss	132-135	matrix metallopeptidase 9	Homo sapiens	5-9
24913675-7	2014	High endothelial MMP9 expression and ascites were independent predictors of reduced DSS and overall survival, together resulting in worst patient prognosis.	dss	84-87	matrix metallopeptidase 9	Homo sapiens	17-21
24650297-10	2014	Survival, however, was only influenced in advanced carcinomas, where loss of MTUS1 was associated with adverse OS and DSS.	dss	118-121	microtubule associated scaffold protein 1	Homo sapiens	77-82
24548858-8	2014	RAD21 expression was associated with shorter DSS in patients with KRAS mutant tumours (HR:2.6, 95% CI:1.4-4.3, P=0.001) and in patients receiving adjuvant chemoradiotherapy (HR:1.9, 95% CI:1.2-3.0, P=0.008).	dss	45-48	RAD21 cohesin complex component	Homo sapiens	0-5
24686517-5	2014	The levels of TNF-alpha and IFN-gamma increased, but IL-6, IL-17A and IL-4 decreased in lamina propria (LP) of colon in immune milk-fed mice with DSS-induced colitis.	dss	146-149	interleukin 6	Mus musculus	53-57
24686517-5	2014	The levels of TNF-alpha and IFN-gamma increased, but IL-6, IL-17A and IL-4 decreased in lamina propria (LP) of colon in immune milk-fed mice with DSS-induced colitis.	dss	146-149	interleukin 17A	Mus musculus	59-65
24686517-5	2014	The levels of TNF-alpha and IFN-gamma increased, but IL-6, IL-17A and IL-4 decreased in lamina propria (LP) of colon in immune milk-fed mice with DSS-induced colitis.	dss	146-149	interleukin 4	Mus musculus	70-74
24548858-8	2014	RAD21 expression was associated with shorter DSS in patients with KRAS mutant tumours (HR:2.6, 95% CI:1.4-4.3, P=0.001) and in patients receiving adjuvant chemoradiotherapy (HR:1.9, 95% CI:1.2-3.0, P=0.008).	dss	45-48	KRAS proto-oncogene, GTPase	Homo sapiens	66-70
24270408-10	2014	The ability of cGMP signaling to inhibit JNK-induced apoptosis in vivo was demonstrated using dextran sodium sulfate (DSS) to stress the colon epithelium.	dss	118-121	mitogen-activated protein kinase 8	Mus musculus	41-44
23860725-6	2014	Patients with an elevated-CEA level or a CD44v6-negative tumor had a worse disease-specific survival (DSS) than those with a normal-CEA level or CD44v6-positive tumor (P = 0.024, P = 0.012, respectively).	dss	102-105	CEA cell adhesion molecule 3	Homo sapiens	26-29
24744797-2	2014	In this study, we examined the relationship between cyclin D1 overexpression and disease-specific survival (DSS).	dss	108-111	cyclin D1	Homo sapiens	52-61
24744797-7	2014	Cyclin D1 overexpression was significantly associated with longer DSS (5-year DSS, 89.9% in patients without cyclin D1 overexpression vs. 98.9% in patients with cyclin D1 overexpression; p=0.008).	dss	66-69	cyclin D1	Homo sapiens	0-9
24744797-7	2014	Cyclin D1 overexpression was significantly associated with longer DSS (5-year DSS, 89.9% in patients without cyclin D1 overexpression vs. 98.9% in patients with cyclin D1 overexpression; p=0.008).	dss	78-81	cyclin D1	Homo sapiens	0-9
24744797-11	2014	CONCLUSION: Cyclin D1 overexpression is associated with longer DSS, but not recurrence-free survival, in patients with breast cancer.	dss	63-66	cyclin D1	Homo sapiens	12-21
24005052-4	2014	Elevated PHIP copy number was associated with significantly reduced distant metastasis-free survival (DMFS; P=0.01) and disease-specific survival (DSS; P=0.009) by Kaplan-Meier analyses.	dss	147-150	pleckstrin homology domain interacting protein	Homo sapiens	9-13
24005052-5	2014	PHIP FISH scores were independently predictive of DMFS (P=0.03) and DSS (P=0.03).	dss	68-71	pleckstrin homology domain interacting protein	Homo sapiens	0-4
24449194-5	2014	The Kaplan-Meier analysis demonstrated that patients with pN2 and pN1 had a significantly worse DSS compared with patients with pN0 tumors (respectively, 17.273 +- 1.020 and 27.145 +- 1.715 vs. 34.992 +- 2.143 months; P &lt; 0.001).	dss	96-99	amyloid beta precursor protein	Homo sapiens	58-61
24449194-5	2014	The Kaplan-Meier analysis demonstrated that patients with pN2 and pN1 had a significantly worse DSS compared with patients with pN0 tumors (respectively, 17.273 +- 1.020 and 27.145 +- 1.715 vs. 34.992 +- 2.143 months; P &lt; 0.001).	dss	96-99	serpin family E member 2	Homo sapiens	66-69
25204186-9	2014	Compared with the cont group, the DSS group showed significantly higher DAI and colonic mucosal lesions, remarkable increase in NF-kappaB p65, IL-8, TNF-alpha expression in colonic tissues, and notable decrease in IL-10 expression (P &lt; 0.05).	dss	34-37	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	138-141
25204186-9	2014	Compared with the cont group, the DSS group showed significantly higher DAI and colonic mucosal lesions, remarkable increase in NF-kappaB p65, IL-8, TNF-alpha expression in colonic tissues, and notable decrease in IL-10 expression (P &lt; 0.05).	dss	34-37	chemokine (C-X-C motif) ligand 15	Mus musculus	143-147
25204186-9	2014	Compared with the cont group, the DSS group showed significantly higher DAI and colonic mucosal lesions, remarkable increase in NF-kappaB p65, IL-8, TNF-alpha expression in colonic tissues, and notable decrease in IL-10 expression (P &lt; 0.05).	dss	34-37	tumor necrosis factor	Mus musculus	149-158
25204186-9	2014	Compared with the cont group, the DSS group showed significantly higher DAI and colonic mucosal lesions, remarkable increase in NF-kappaB p65, IL-8, TNF-alpha expression in colonic tissues, and notable decrease in IL-10 expression (P &lt; 0.05).	dss	34-37	interleukin 10	Mus musculus	214-219
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	chemokine (C-X-C motif) ligand 15	Mus musculus	141-145
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	tumor necrosis factor	Mus musculus	147-156
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	171-174
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	interleukin 10	Mus musculus	208-213
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	chemokine (C-X-C motif) ligand 15	Mus musculus	141-145
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	tumor necrosis factor	Mus musculus	147-156
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	171-174
25204186-12	2014	Compared with the DSS group, the DSS + FOD-H group and the DSS + FOD-M group showed reduction in colonic mucosal lesions, down-regulation in IL-8, TNF-alpha and NF-kappaB p65 expressions and up-regulation in IL-10 expression (P &lt; 0.05).	dss	33-36	interleukin 10	Mus musculus	208-213
24274692-6	2014	Patients whose tumours showed high GPD1L protein expression had a significantly better prognosis than those whose tumours showed low expression (61.3% versus 21.4%, P &lt; 0.001 for DFS; 68% versus 39.3%, P = 0.001 for DSS).	dss	219-222	glycerol-3-phosphate dehydrogenase 1 like	Homo sapiens	35-40
23408349-9	2014	E2-treated animals showed increased clinical symptoms and Il-6 production upon DSS-induced colitis and enhanced epithelial proliferation.	dss	79-82	interleukin 6	Mus musculus	58-62
25668612-8	2015	In a multivariate analysis, positive PR expression in the tumor stroma (P=0.007) was an independent prognostic factor for improved disease-specific survival (DSS).	dss	158-161	progesterone receptor	Homo sapiens	37-39
25668612-9	2015	Positive PR expression in tumor epithelial cells emerged as an independent prognostic factor in female patients (P=0.001) for poor DSS.	dss	131-134	progesterone receptor	Homo sapiens	9-11
25668612-10	2015	CONCLUSIONS: We show that PR expression in tumor-surrounding stromal cells is associated with improved DSS for both male and female patients.	dss	103-106	progesterone receptor	Homo sapiens	26-28
25668612-11	2015	Additionally, we reveal that positive PR expression in tumor epithelial cells is an independent, unfavorable prognosticator for DSS in female patients, making PR expression a potential marker for prognostic stratification in NSCLC.	dss	128-131	progesterone receptor	Homo sapiens	38-40
24374874-2	2014	We hypothesized that NIRF probes activatable by cathepsins or metalloproteinases will detect and quantify dextran sulphate sodium (DSS)-induced acute colonic inflammation in wild type mice or chronic colitis in interleukin-10 (IL-10)-null mice ex vivo or in vivo.	dss	131-134	interleukin 10	Mus musculus	211-225
24374874-2	2014	We hypothesized that NIRF probes activatable by cathepsins or metalloproteinases will detect and quantify dextran sulphate sodium (DSS)-induced acute colonic inflammation in wild type mice or chronic colitis in interleukin-10 (IL-10)-null mice ex vivo or in vivo.	dss	131-134	interleukin 10	Mus musculus	227-232
24390064-6	2014	The number of immature and mature platelets, activated platelets, and platelet-leukocyte aggregates were measured in wild-type and IL-6 mice with dextran sodium sulfate (DSS)-induced colonic inflammation.	dss	170-173	interleukin 6	Mus musculus	131-135
24305009-5	2014	RESULTS: In univariate analyses, high cancer cell (p=0.039) and high stromal cell expression (p=0.008) of miR-210 were both significantly associated with an improved disease-spesific survival (DSS).	dss	193-196	microRNA 210	Homo sapiens	106-113
24305009-6	2014	High co-expression of miR-210 in cancer and stromal cells was also a positive prognostic factor for DSS (p=0.010).	dss	100-103	microRNA 210	Homo sapiens	22-29
24305009-7	2014	In multivariate analysis, miR-210 in stromal cells (p=0.011), and miR-210 co-expressed in cancer and stromal cells was an independent prognosticator for DSS (p=0.011).	dss	153-156	microRNA 210	Homo sapiens	66-73
24081675-7	2014	Fibronectin overexpression was significantly associated with American Joint Committee on Cancer (AJCC) stages III-IV (p = 0.019) and LMP1 expression (p = 0.004), and univariately predictive of adverse outcomes for DSS, DMFS, and LRFS (all p &lt; 0.0001).	dss	214-217	fibronectin 1	Homo sapiens	0-11
24081675-8	2014	In the multivariate comparison, fibronectin overexpression still remained prognostically independent to portend worse DSS (p &lt; 0.01, hazard ratio = 5.958), DMFS (p &lt; 0.01, hazard ratio = 5.728), and LRFS (p &lt; 0.01, hazard ratio = 5.411) together with a vanced AJCC stages III-IV.	dss	118-121	fibronectin 1	Homo sapiens	32-43
24114011-10	2014	Importantly, BCL6 overexpression in GBC was strongly associated with worse DSS (p &lt; 0.0001) and DFS (p &lt; 0.0001) in the univariate analysis, and remained independently predictive of adverse outcomes (p = 0.001, hazard ratio (H.R.)	dss	75-78	BCL6 transcription repressor	Homo sapiens	13-17
24114011-13	2014	Low p19(ARF) expression was correlated with a poor DSS (p = 0.0144) and DFS (p = 0.0032) in the univariate analysis but was not prognosticatory in the multivariate analysis.	dss	51-54	cyclin dependent kinase inhibitor 2A	Homo sapiens	4-7
24114011-15	2014	BCL6 overexpression also independently predicts worse DSS and DFS, suggesting it has a role in tumorigenesis or carcinogenesis and could be a potential prognostic indicator in GBC.	dss	54-57	BCL6 transcription repressor	Homo sapiens	0-4
24444363-12	2014	FGFR-1 was an independent positive prognosticator for DSS (HR = 0.243, 95% CI = 0.095-0.618, P = 0.003) in the VR group.	dss	54-57	fibroblast growth factor receptor 1	Homo sapiens	0-6
24306512-10	2014	C75 protected colon tissues from DSS-induced apoptosis by inhibiting caspase-3 activity.	dss	33-36	caspase 3	Mus musculus	69-78
24864233-10	2014	Nodal status, tumor grade, recurrence, and CD8+/Tregs ratio were identified as factors influencing DSS.	dss	99-102	CD8a molecule	Homo sapiens	43-46
25036966-4	2014	Dietary treatment with alpha-lactalbumin decreased fecal occult blood score at 3 days after DSS intake.	dss	92-95	lactalbumin, alpha	Mus musculus	23-40
24116743-6	2014	KEY RESULTS: DSS-induced colitis in mice markedly increased TnC in the damaged mucosal areas and up-regulated mRNA for TnC, pro-inflammatory cytokines and growth factors (PDGF-B and TGF-beta1).	dss	13-16	tenascin C	Mus musculus	60-63
24116743-6	2014	KEY RESULTS: DSS-induced colitis in mice markedly increased TnC in the damaged mucosal areas and up-regulated mRNA for TnC, pro-inflammatory cytokines and growth factors (PDGF-B and TGF-beta1).	dss	13-16	tenascin C	Mus musculus	119-122
24116743-6	2014	KEY RESULTS: DSS-induced colitis in mice markedly increased TnC in the damaged mucosal areas and up-regulated mRNA for TnC, pro-inflammatory cytokines and growth factors (PDGF-B and TGF-beta1).	dss	13-16	platelet derived growth factor, B polypeptide	Mus musculus	171-177
24116743-6	2014	KEY RESULTS: DSS-induced colitis in mice markedly increased TnC in the damaged mucosal areas and up-regulated mRNA for TnC, pro-inflammatory cytokines and growth factors (PDGF-B and TGF-beta1).	dss	13-16	transforming growth factor, beta 1	Mus musculus	182-191
24116743-11	2014	Knock-down of TnC gene increased susceptibility to DSS-induced colitis, compared with TnC(+/+) littermates.	dss	51-54	tenascin C	Mus musculus	14-17
25551582-11	2014	In ovarian tumors, elafin-positive cells were correlated with reduced RFS, OS and disease-specific survival (DSS) only in stage I/II patients and not in stage III/IV patients.	dss	109-112	peptidase inhibitor 3	Homo sapiens	19-25
24591754-7	2014	MicroRNA-210 was also a significant predictor for overall survival (OS), metastasis free survival or distant relapse free survival (MFS/DRFS), and disease specific survival (DSS).	dss	174-177	microRNA 210	Homo sapiens	0-12
24395090-0	2014	Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice.	dss	100-103	vasoactive intestinal polypeptide	Mus musculus	14-47
24395090-0	2014	Inhibition of vasoactive intestinal polypeptide (VIP) induces resistance to dextran sodium sulfate (DSS)-induced colitis in mice.	dss	100-103	vasoactive intestinal polypeptide	Mus musculus	49-52
24395090-3	2014	Our aim was to determine the participation of VIP on dextran sodium sulfate (DSS)-induced colonic mucosal inflammation using VIP(-/-) and WT mice treated with VIP antagonists.	dss	77-80	vasoactive intestinal polypeptide	Mus musculus	46-49
24395090-5	2014	DSS-treated WT mice were injected daily with VIP antagonists, VIPHyb (n = 22), PG 97-269 (n = 9), or vehicle (n = 31).	dss	0-3	vasoactive intestinal polypeptide	Mus musculus	45-48
24395090-7	2014	VIP(-/-) mice were remarkably resistant to DSS-induced colitis compared to WT.	dss	43-46	vasoactive intestinal polypeptide	Mus musculus	0-3
24492412-4	2014	Up to day 7, inflammatory markers were significantly increased in the livers of DSS-treated mice, accompanied by decreased CYP3A.	dss	80-83	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	123-128
24492412-6	2014	Both CYP3A and P-gp were significantly decreased in the upper small intestine of DSS-treated mice on day 7.	dss	81-84	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	5-10
24492412-6	2014	Both CYP3A and P-gp were significantly decreased in the upper small intestine of DSS-treated mice on day 7.	dss	81-84	phosphoglycolate phosphatase	Mus musculus	15-19
24492412-8	2014	On day 7 of DSS treatment, the concentrations of cyclosporine A (CsA), a substrate of both CYP3A and P-gp, were significantly higher than controls.	dss	12-15	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	91-96
24492412-8	2014	On day 7 of DSS treatment, the concentrations of cyclosporine A (CsA), a substrate of both CYP3A and P-gp, were significantly higher than controls.	dss	12-15	phosphoglycolate phosphatase	Mus musculus	101-105
24211084-9	2014	The 3-year post-DM disease-specific survival (DSS) estimate in the p16-positive patients was 16% (95% CI: 7-18%) while all p16-negative patients died within 34 months (p&lt;0.001).	dss	46-49	cyclin dependent kinase inhibitor 2A	Homo sapiens	67-70
24211084-10	2014	p16-negativity, loco-regional disease, and no/palliative versus curative intent treatment were all associated with reduced post-DM DSS in multivariate analysis.	dss	131-134	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
23897555-7	2014	ASS1 protein deficiency was identified in 64 of 124 cases (51.6%), significantly related to T3-T4 status (p = 0.006), and univariately associated with inferior local recurrence-free survival (p = 0.0427), distant metastasis-free survival (DMFS; p = 0.0036), and disease-specific survival (DSS; p = 0.0069).	dss	289-292	argininosuccinate synthase 1	Homo sapiens	0-4
23897555-8	2014	Together with advanced AJCC stages III-IV, ASS1 protein deficiency was also independently predictive of worse outcomes for the DFMS (p = 0.010, hazard ratio = 2.241) and DSS (p = 0.020, hazard ratio = 1.900).	dss	170-173	argininosuccinate synthase 1	Homo sapiens	43-47
23897556-7	2014	TOP2A overexpression was significantly associated with American Joint of Cancer Committee (AJCC) stages III-IV (p = 0.019) and univariately predictive of adverse outcomes for DSS (p = 0.0078) and DMFS (p = 0.0003).	dss	175-178	DNA topoisomerase II alpha	Homo sapiens	0-5
23897556-8	2014	In the multivariate comparison, TOP2A overexpression remained prognostically independent to portend worse DSS (p = 0.047, hazard ratio = 1.732) and DMFS (p = 0.003, hazard ratio = 2.569), together with advanced AJCC stages III-IV.	dss	106-109	DNA topoisomerase II alpha	Homo sapiens	32-37
24360666-7	2014	On univariable analysis, a higher pT stage, pN+, the presence of lymphovascular invasion (LVI) and vascular invasion (VI) (all P&lt;0.001), and overexpressions of VEGF-D (P = 0.049) and VEGFR-3 (P = 0.032) were significantly associated with reduced DSS.	dss	249-252	vascular endothelial growth factor D	Homo sapiens	163-169
24360666-9	2014	In a subgroup of patients without lymph node metastasis (pN0; n = 75), pT stage (P = 0.043) and VEGFR-3 overexpression (P = 0.008) were independent predictors of reduced DSS.	dss	170-173	fms related receptor tyrosine kinase 4	Homo sapiens	96-103
25138778-4	2014	CRP was analyzed as a categorical and continuous variable for the prediction of recurrence-free survival (RFS), disease-specific survival (DSS) and all-cause survival (ACS) using uni- and multivariate Cox regression analyses.	dss	139-142	C-reactive protein	Homo sapiens	0-3
25138778-7	2014	In a multivariable Cox regression model adjusted for features significant in univariable analysis, categorized and continuous CRP levels were both independent predictors for RFS [hazard ratio (HR) 1.18, p = 0.050; HR 1.03, p = 0.012] and DSS (HR 1.61, p = 0.026; HR 1.06, p = 0.001).	dss	238-241	C-reactive protein	Homo sapiens	126-129
24350944-14	2013	The 5 year disease specific survival (DSS) was 73% for p16 positive tumors and 35% for p16 negative tumors (p &lt; 0.001).	dss	38-41	cyclin dependent kinase inhibitor 2A	Homo sapiens	55-58
24350944-14	2013	The 5 year disease specific survival (DSS) was 73% for p16 positive tumors and 35% for p16 negative tumors (p &lt; 0.001).	dss	38-41	cyclin dependent kinase inhibitor 2A	Homo sapiens	87-90
24350944-16	2013	Patients with p16 positive and basaloid differentiated tumors had the best survival outcomes with a 5 year DSS of 80%.	dss	107-110	cyclin dependent kinase inhibitor 2A	Homo sapiens	14-17
24339954-4	2013	The genes associated with disease-specific survival (DSS) and liver-recurrence-free survival (LRFS) were identified by Cox-regression and selected to construct a molecular risk score (MRS) using the supervised principle component method on the training set.	dss	53-56	cytochrome c oxidase subunit 8A	Homo sapiens	119-122
24028683-8	2013	Moreover, IL-17A mRNA levels were elevated significantly by the TFA diet, with or without DSS treatment.	dss	90-93	interleukin 17A	Mus musculus	10-16
23172891-7	2013	In two experimental models of IBD, genetic ablation of ST2 significantly improved signs of colitis, while a sustained epithelial expression of the cyto-protective factor connexin-43 was observed in DSS-treated St2-deficient mice.	dss	198-201	gap junction protein, alpha 1	Mus musculus	170-181
23172891-7	2013	In two experimental models of IBD, genetic ablation of ST2 significantly improved signs of colitis, while a sustained epithelial expression of the cyto-protective factor connexin-43 was observed in DSS-treated St2-deficient mice.	dss	198-201	interleukin 1 receptor-like 1	Mus musculus	210-213
23172891-9	2013	Consistently, specific inhibition of endogenous ST2-mediated signalling by treatment with neutralising antibody improved DSS-induced colitis.	dss	121-124	interleukin 1 receptor-like 1	Mus musculus	48-51
23468305-5	2013	The univariate analysis showed a significant difference in DSS between pT1 and pT2 oropharyngeal carcinoma (DSS, 94.0% vs 81.2%; p = .008) and patients with tumor depth greater than 5 mm (DSS, 94.5% vs 78.9%; p = .031).	dss	59-62	zinc finger protein 77	Homo sapiens	71-74
23643871-11	2013	In multivariate analysis adjusting for age, stage, and tumor diameter, galectin-7 expression remained a significant predictor of DMFS (hazard ratio [HR]=0.43, p=0.03), DSS (HR=0.34, p=0.001), and OS (HR=0.34, p=0.001).	dss	168-171	galectin 7	Homo sapiens	71-81
24065141-3	2013	The expression levels of REG family genes were evaluated by real-time RT-PCR in surgically resected lung cancers, and disease-specific survival (DSS) curves were generated.	dss	145-148	regenerating family member 1 alpha	Homo sapiens	25-28
23838801-10	2013	High expression of NNMT correlated significantly with a more aggressive clinical course and a significantly shorter DSS.	dss	116-119	nicotinamide N-methyltransferase	Homo sapiens	19-23
23783813-6	2013	Compared with the control, mice receiving DSS alone had increased diarrhea and mucosa histological scores (P &lt; 0.05), as well as lipid peroxidation (P &lt; 0.05), myeloperoxidase (P &lt; 0.05), and active NF-kappaB in colonic tissue (P &lt; 0.05).	dss	42-45	myeloperoxidase	Mus musculus	166-181
23986515-10	2013	Our results suggest that KC/IL-8 and its receptor CXCR2 are critical and major mediators of organ cross talk in DSS colitis and neutralization of CXCR2 will help to reduce the incidence of acute kidney injury due to ulcerative colitis and Crohn"s disease in humans.	dss	112-115	C-X-C motif chemokine receptor 2	Homo sapiens	50-55
24244446-6	2013	DSS-induced disease in Smad3(-/-) mice may be a useful animal model to study not only inflammation-driven MAC but other human diseases such as colitis cystica profunda (CCP) and pseudomyxomatous peritonei (PMP).	dss	0-3	SMAD family member 3	Mus musculus	23-28
24223168-10	2013	Intratumoral IL-6 and IL-11 expression increased in DSS-treated mice and IL-6, and possibly IL-11, were enhanced by dietary iron.	dss	52-55	interleukin 6	Mus musculus	13-17
24223168-10	2013	Intratumoral IL-6 and IL-11 expression increased in DSS-treated mice and IL-6, and possibly IL-11, were enhanced by dietary iron.	dss	52-55	interleukin 11	Mus musculus	22-27
24102179-10	2013	CRP levels were found to be a strong prognostic factor for DSS in CC.	dss	59-62	C-reactive protein	Homo sapiens	0-3
23910226-1	2013	AIMS: To improve prediction efficiency by incorporating complete blood count (CBC) into the TNM system on 5 year disease-specific survival (DSS) for patients with nasopharyngeal carcinoma (NPC).	dss	140-143	teneurin transmembrane protein 1	Homo sapiens	92-95
23809767-10	2013	In multivariate Cox regression analyses, high NR4A2 expression in cancer nuclei (immunoreactive score &gt;= 4) significantly predicted a shorter disease-specific survival (DSS) of CRC patients (hazard ratio [HR]=1.88, P=0.024).	dss	172-175	nuclear receptor subfamily 4 group A member 2	Homo sapiens	46-51
23809767-11	2013	High NR4A2 expression specifically predicted a shorter DSS of colon cancer patients (dichotomisation, HR=2.55, log-rank test P=0.011), especially for those who received postoperative 5-fluorouracil/leucovorin plus oxaliplatin (FOLFOX) chemotherapy (3-score range, HR=1.86, log-rank test P=0.020).	dss	55-58	nuclear receptor subfamily 4 group A member 2	Homo sapiens	5-10
24146755-2	2013	Here we report that RASSF1A is a novel regulator of intestinal inflammation as Rassf1a(+/-) , Rassf1a(-/-) and an intestinal epithelial cell specific knockout mouse (Rassf1a (IEC-KO) ) rapidly became sick following dextran sulphate sodium (DSS) administration, a chemical inducer of colitis.	dss	240-243	Ras association (RalGDS/AF-6) domain family member 1	Mus musculus	20-27
24146755-4	2013	Furthermore, epithelial restitution/repair was inhibited in DSS-treated Rassf1a(-/-) mice with reduction of several makers of proliferation including Yes associated protein (YAP)-driven proliferation.	dss	60-63	Ras association (RalGDS/AF-6) domain family member 1	Mus musculus	72-79
24146755-4	2013	Furthermore, epithelial restitution/repair was inhibited in DSS-treated Rassf1a(-/-) mice with reduction of several makers of proliferation including Yes associated protein (YAP)-driven proliferation.	dss	60-63	yes-associated protein 1	Mus musculus	150-172
24146755-4	2013	Furthermore, epithelial restitution/repair was inhibited in DSS-treated Rassf1a(-/-) mice with reduction of several makers of proliferation including Yes associated protein (YAP)-driven proliferation.	dss	60-63	yes-associated protein 1	Mus musculus	174-177
24146755-5	2013	Surprisingly, tyrosine phosphorylation of YAP was detected which coincided with increased nuclear p73 association, Bax-driven epithelial cell death and p53 accumulation resulting in enhanced apoptosis and poor survival of DSS-treated Rassf1a knockout mice.	dss	222-225	yes-associated protein 1	Mus musculus	42-45
24146755-5	2013	Surprisingly, tyrosine phosphorylation of YAP was detected which coincided with increased nuclear p73 association, Bax-driven epithelial cell death and p53 accumulation resulting in enhanced apoptosis and poor survival of DSS-treated Rassf1a knockout mice.	dss	222-225	Ras association (RalGDS/AF-6) domain family member 1	Mus musculus	234-241
24146755-6	2013	We can inhibit these events and promote the survival of DSS-treated Rassf1a knockout mice with intraperitoneal injection of the c-Abl and c-Abl related protein tyrosine kinase inhibitor, imatinib/gleevec.	dss	56-59	Ras association (RalGDS/AF-6) domain family member 1	Mus musculus	68-75
24146755-6	2013	We can inhibit these events and promote the survival of DSS-treated Rassf1a knockout mice with intraperitoneal injection of the c-Abl and c-Abl related protein tyrosine kinase inhibitor, imatinib/gleevec.	dss	56-59	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	128-133
24146755-6	2013	We can inhibit these events and promote the survival of DSS-treated Rassf1a knockout mice with intraperitoneal injection of the c-Abl and c-Abl related protein tyrosine kinase inhibitor, imatinib/gleevec.	dss	56-59	c-abl oncogene 1, non-receptor tyrosine kinase	Mus musculus	138-143
24146755-8	2013	These observations suggest that tyrosine phosphorylation of YAP (to drive p73 association and up-regulation of pro-apoptotic genes such as Bax) and accumulation of p53 are consequences of inflammation-induced injury in DSS-treated Rassf1a(-/-) mice.	dss	219-222	yes-associated protein 1	Mus musculus	60-63
24146755-8	2013	These observations suggest that tyrosine phosphorylation of YAP (to drive p73 association and up-regulation of pro-apoptotic genes such as Bax) and accumulation of p53 are consequences of inflammation-induced injury in DSS-treated Rassf1a(-/-) mice.	dss	219-222	transformation related protein 73	Mus musculus	74-77
24146755-8	2013	These observations suggest that tyrosine phosphorylation of YAP (to drive p73 association and up-regulation of pro-apoptotic genes such as Bax) and accumulation of p53 are consequences of inflammation-induced injury in DSS-treated Rassf1a(-/-) mice.	dss	219-222	BCL2-associated X protein	Mus musculus	139-142
24146755-8	2013	These observations suggest that tyrosine phosphorylation of YAP (to drive p73 association and up-regulation of pro-apoptotic genes such as Bax) and accumulation of p53 are consequences of inflammation-induced injury in DSS-treated Rassf1a(-/-) mice.	dss	219-222	transformation related protein 53, pseudogene	Mus musculus	164-167
24146755-8	2013	These observations suggest that tyrosine phosphorylation of YAP (to drive p73 association and up-regulation of pro-apoptotic genes such as Bax) and accumulation of p53 are consequences of inflammation-induced injury in DSS-treated Rassf1a(-/-) mice.	dss	219-222	Ras association (RalGDS/AF-6) domain family member 1	Mus musculus	231-238
24228112-7	2013	The 5-year disease-specific survival (DSS) in high expression of BGN group is poorer than that in low level expression group (36.8% VS 57.4%, P = 0.006).	dss	38-41	biglycan	Homo sapiens	65-68
23720072-10	2013	CONCLUSIONS: This study emphasizes the 3-cm size, and possibly the 6-cm size, as informative predictive thresholds when ablating HCC, because variability of DSS occurred specifically at these tumor sizes.	dss	157-160	HCC	Homo sapiens	129-132
23807662-7	2013	A Kaplan-Meier analysis of the bladder cancer patients with negative SNAI1 expression showed significantly reduced disease-specific survival (DSS) and progression-free survival (PFS) compared to the patients with positive expression (p = 0.010 and 0.013).	dss	142-145	snail family transcriptional repressor 1	Homo sapiens	69-74
23807662-8	2013	A multivariate Cox regression analysis (adjusted for gender, age, tumor stage, tumor grade, lymph node metastasis, chemotherapy, and histologic subtype) again showed a significant correlation between patients lacking SNAI1 expression and DSS (p = 0.005; relative risk 2.31; 95 % confidence interval 1.28-4.17) or PFS (p = 0.004; relative risk 2.20; 95 % confidence interval 1.29-3.78) compared to patients with positive SNAI1 staining.	dss	238-241	snail family transcriptional repressor 1	Homo sapiens	217-222
23807662-9	2013	CONCLUSIONS: Loss of SNAI1 protein expression is an independent prognosticator for PFS and DSS in bladder cancer patients treated by radical cystectomy and adjuvant chemotherapy.	dss	91-94	snail family transcriptional repressor 1	Homo sapiens	21-26
23707215-11	2013	FTR (in the absence of DSS) increased gene expression of the chemokine and antibacterial protein CCL6 suggesting that FTR altered gut homeostasis that may be related to the exaggerated response to DSS.	dss	197-200	chemokine (C-C motif) ligand 6	Mus musculus	97-101
23640071-4	2013	When damaged by dextran sodium sulfate (DSS), the increased proliferative capacity of Myc 3" WRE(-/-) colonocytes resulted in a more rapid recovery compared with wild-type (WT) mice.	dss	40-43	myelocytomatosis oncogene	Mus musculus	86-89
23640071-6	2013	PURPOSE: To characterize the innate immune response in Myc 3" WRE(-/-) and WT mice during and after DSS-induced colonic injury.	dss	100-103	myelocytomatosis oncogene	Mus musculus	55-58
23640071-10	2013	RESULTS: In comparison with WT mice, there was enhanced leukocyte infiltration into the colonic mucosal and submucosal layers of Myc 3" WRE(-/-) mice after DSS damage.	dss	156-159	myelocytomatosis oncogene	Mus musculus	129-132
23640071-12	2013	CONCLUSION: The Myc 3" WRE regulates neutrophil infiltration into DSS-damaged colons.	dss	66-69	myelocytomatosis oncogene	Mus musculus	16-19
22833394-6	2013	Mtg16(-/-) mice developed increased weight loss, diarrhoea, mortality and histological colitis and there were increased innate (Gr1(+), F4/80(+), CD11c(+) and MHCII(+); CD11c(+)) and Th1 adaptive (CD4) immune cells in Mtg16(-/-) colons after DSS treatment.	dss	242-245	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	0-5
22833394-8	2013	Compared with wild-type mice, Mtg16(-/-) mice exhibited increased colonic CD4;IFN-gamma cells in vehicle-treated and DSS-treated mice.	dss	117-120	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	30-35
22833394-10	2013	Isolated colonic epithelial cells from DSS-treated Mtg16(-/-) mice exhibited increased KC (Cxcl1) mRNA expression when compared with wild-type mice.	dss	39-42	CBFA2/RUNX1 partner transcriptional co-repressor 3	Homo sapiens	51-56
22833394-10	2013	Isolated colonic epithelial cells from DSS-treated Mtg16(-/-) mice exhibited increased KC (Cxcl1) mRNA expression when compared with wild-type mice.	dss	39-42	chemokine (C-X-C motif) ligand 1	Mus musculus	91-96
23782400-8	2013	On multivariate analysis, independent predictors of DSS for 3-year survivors were recurrence within the first 3 years after a liver resection, a pre-operative carcinoembryonic antigen (CEA) &gt;200 ng/ml and disease-free interval &lt;12 months prior to the diagnosis of liver metastasis.	dss	52-55	CEA cell adhesion molecule 3	Homo sapiens	159-183
23782400-8	2013	On multivariate analysis, independent predictors of DSS for 3-year survivors were recurrence within the first 3 years after a liver resection, a pre-operative carcinoembryonic antigen (CEA) &gt;200 ng/ml and disease-free interval &lt;12 months prior to the diagnosis of liver metastasis.	dss	52-55	CEA cell adhesion molecule 3	Homo sapiens	185-188
23942946-1	2013	The aim of this study was to determine the therapeutic efficacy of lactoferrin (Lf) on dextran sulphate sodium (DSS)-induced experimental colitis in BALB/c mice.	dss	112-115	lactotransferrin	Mus musculus	67-78
23942946-1	2013	The aim of this study was to determine the therapeutic efficacy of lactoferrin (Lf) on dextran sulphate sodium (DSS)-induced experimental colitis in BALB/c mice.	dss	112-115	lactotransferrin	Mus musculus	80-82
24065530-5	2013	The down-regulation of Apc expression in left colon, detectable in animals treated with DSS-AOM and sacrificed 1 month after the end of treatment, represents most early marker of the experimental colorectal carcinogenesis.	dss	88-91	APC regulator of WNT signaling pathway	Rattus norvegicus	23-26
24065530-6	2013	Significantly reduced gene expressions were also found in 5 out of 7 studied MMR genes (Mlh1, Mlh3, Msh3 Pms1, Pms2), regarding the sequential administration of DSS-AOM at 4 months since the treatment.	dss	161-164	mutL homolog 1	Rattus norvegicus	88-92
24065530-6	2013	Significantly reduced gene expressions were also found in 5 out of 7 studied MMR genes (Mlh1, Mlh3, Msh3 Pms1, Pms2), regarding the sequential administration of DSS-AOM at 4 months since the treatment.	dss	161-164	mutL homolog 3	Rattus norvegicus	94-98
24065530-6	2013	Significantly reduced gene expressions were also found in 5 out of 7 studied MMR genes (Mlh1, Mlh3, Msh3 Pms1, Pms2), regarding the sequential administration of DSS-AOM at 4 months since the treatment.	dss	161-164	mutS homolog 3	Rattus norvegicus	100-104
24065530-6	2013	Significantly reduced gene expressions were also found in 5 out of 7 studied MMR genes (Mlh1, Mlh3, Msh3 Pms1, Pms2), regarding the sequential administration of DSS-AOM at 4 months since the treatment.	dss	161-164	PMS1 homolog 1, mismatch repair system component	Rattus norvegicus	105-109
24065530-6	2013	Significantly reduced gene expressions were also found in 5 out of 7 studied MMR genes (Mlh1, Mlh3, Msh3 Pms1, Pms2), regarding the sequential administration of DSS-AOM at 4 months since the treatment.	dss	161-164	PMS1 homolog 2, mismatch repair system component	Rattus norvegicus	111-115
23971882-17	2013	Western blots showed a trend to increased claudin-1 and claudin-2 expressions in DSS mice.	dss	81-84	claudin 1	Mus musculus	42-51
23971882-17	2013	Western blots showed a trend to increased claudin-1 and claudin-2 expressions in DSS mice.	dss	81-84	claudin 2	Mus musculus	56-65
23722602-6	2013	The results of HuR expression were correlated with various clinicopathological factors, disease-specific survival (DSS), and disease-free survival (DFS) in 161 patients with follow-up data.	dss	115-118	ELAV like RNA binding protein 1	Homo sapiens	15-18
23722602-10	2013	HuR-N overexpression correlated with poor DFS (p = 0.0348) in univariate analysis, but HuR-C overexpression strongly correlated with a worse DSS and DFS in both univariate (both p &lt; 0.0001) and multivariate (DSS, p = 0.006; DFS, p = 0.001) analyses.	dss	141-144	ELAV like RNA binding protein 1	Homo sapiens	87-90
23722602-12	2013	Besides, HuR-C overexpression is an independent prognostic factor for dismal DSS and DFS, suggesting its roles in tumorigenesis or carcinogenesis and as a potential prognostic marker of GBC.	dss	77-80	ELAV like RNA binding protein 1	Homo sapiens	9-12
22544338-7	2013	Five-year disease-specific survival (DSS) rates were 57.5 % in UC and 39.1 % in SCC group (p = 0.011).	dss	37-40	serpin family B member 3	Homo sapiens	80-83
22544338-8	2013	Five-year DSS rates were 81.2 % in UC and 75.0 % in SCC group in organ-confined disease (p = 0.534) and 28.2 % in UC and 40.9 % in SCC group in extravesical disease (p = 0.845).	dss	10-13	serpin family B member 3	Homo sapiens	52-55
22544338-9	2013	In lymph node-positive patients, DSS time was 20.9 +- 2.85 months in UC and 12.8 +- 2.07 months in SCC patients (p = 0.182).	dss	33-36	serpin family B member 3	Homo sapiens	99-102
23806714-5	2013	DSS upregulated Nav1.8 mRNA in colon-responsive dorsal root ganglion (DRG) neurons, TRPV1 in colonic muscularis externae (ME) and BDNF in spinal cord without affecting the spike frequency in spinal afferents or VMR to CRD.	dss	0-3	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	16-22
23806714-5	2013	DSS upregulated Nav1.8 mRNA in colon-responsive dorsal root ganglion (DRG) neurons, TRPV1 in colonic muscularis externae (ME) and BDNF in spinal cord without affecting the spike frequency in spinal afferents or VMR to CRD.	dss	0-3	brain-derived neurotrophic factor	Rattus norvegicus	130-134
23797868-3	2013	METHODS: Disease-specific survival (DSS) was assessed among SCC patients with cervical lymph node metastases (n = 347, including 133 patients with OPC and 214 patients with OCC).	dss	36-39	serpin family B member 3	Homo sapiens	60-63
24023849-0	2013	CD137 facilitates the resolution of acute DSS-induced colonic inflammation in mice.	dss	42-45	tumor necrosis factor receptor superfamily, member 9	Mus musculus	0-5
24023849-4	2013	METHODS: We induced acute large bowel inflammation (colitis) via DSS administration in CD137(-/-) and wild-type (WT) mice.	dss	65-68	tumor necrosis factor receptor superfamily, member 9	Mus musculus	87-92
24023849-8	2013	RESULTS: We found that both CD137(-/-) and WT mice demonstrated a similar degree of inflammation after 5 days of DSS exposure.	dss	113-116	tumor necrosis factor receptor superfamily, member 9	Mus musculus	28-33
24023849-12	2013	CONCLUSION: We conclude that CD137 plays an essential role in the resolution of acute DSS-induced intestinal inflammation in mice.	dss	86-89	tumor necrosis factor receptor superfamily, member 9	Mus musculus	29-34
23645481-10	2013	Univariate and multivariate analyses showed REG1A expression status to be a significant prognostic factor affecting 5-year DSS, comparable to lymph node metastatic status.	dss	123-126	regenerating family member 1 alpha	Homo sapiens	44-49
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	dss	27-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	49-54
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	dss	27-30	catenin beta 1	Homo sapiens	70-82
23824743-5	2013	Isorhamnetin inhibited AOM/DSS-induced oncogenic c-Src activation and beta-catenin nuclear translocation, while promoting the expression of C-terminal Src kinase (CSK), a negative regulator of Src family of tyrosine kinases.	dss	27-30	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	51-54
23668821-3	2013	Chronic colitis was induced in Bim-deficient mice (Bim(-/-) ) with dextran sulphate sodium (DSS).	dss	92-95	BCL2-like 11 (apoptosis facilitator)	Mus musculus	31-34
23668821-6	2013	Upon chronic dextran sulphate sodium (DSS)-induced colitis, Bim(-/-) animals exhibited an increased infiltrate of lymphocytes into the mucosa compared to wild-type mice.	dss	38-41	BCL2-like 11 (apoptosis facilitator)	Mus musculus	60-63
23668821-8	2013	Impaired removal of autoreactive lymphocytes in Bim(-/-) mice upon chronic DSS-induced colitis may therefore contribute to aggravated mucosal inflammation.	dss	75-78	BCL2-like 11 (apoptosis facilitator)	Mus musculus	48-51
23582173-3	2013	Significantly, we demonstrate here that IL33 and ST2 are the primary early genes induced in the inflamed colon of BALB/c mice following dextran sulphate sodium (DSS)-induced experimental ulcerative colitis.	dss	161-164	interleukin 33	Mus musculus	40-44
23582173-3	2013	Significantly, we demonstrate here that IL33 and ST2 are the primary early genes induced in the inflamed colon of BALB/c mice following dextran sulphate sodium (DSS)-induced experimental ulcerative colitis.	dss	161-164	interleukin 1 receptor-like 1	Mus musculus	49-52
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	interleukin 1 receptor-like 1	Mus musculus	74-77
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	interleukin 33	Mus musculus	169-174
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	chemokine (C-X-C motif) ligand 9	Mus musculus	252-257
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	chemokine (C-X-C motif) ligand 10	Mus musculus	262-268
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	interleukin 4	Mus musculus	289-293
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	interleukin 13	Mus musculus	295-300
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	interleukin 1 complex	Mus musculus	295-299
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	interleukin 6	Mus musculus	308-312
23582173-4	2013	Accordingly diarrhoea and DSS-induced colon inflammation were impaired in ST2(-/-) BALB/c mice and exacerbated in wild-type mice by treatment with exogenous recombinant IL-33, associated respectively with reduced and enhanced expression of chemokines (CXCL9 and CXCL10), and inflammatory (IL-4, IL-13, IL-1, IL-6, IL-17) and angiogenic (vascular endothelial growth factor) cytokines in vivo.	dss	26-29	interleukin 17A	Mus musculus	314-319
23582173-5	2013	The exacerbation effect of treatment with recombinant IL-33 on DSS-induced acute colitis was abolished in IL-4(-/-) BALB/c mice.	dss	63-66	interleukin 33	Mus musculus	54-59
23582173-5	2013	The exacerbation effect of treatment with recombinant IL-33 on DSS-induced acute colitis was abolished in IL-4(-/-) BALB/c mice.	dss	63-66	interleukin 4	Mus musculus	106-110
23340823-0	2013	Natural killer cells protect mice from DSS-induced colitis by regulating neutrophil function via the NKG2A receptor.	dss	39-42	killer cell lectin-like receptor subfamily C, member 1	Mus musculus	101-106
23340823-6	2013	Our results indicate an immunoregulatory mechanism of action of NK cells attenuating DSS-induced colitis neutrophil-mediated inflammation and tissue injury via NKG2A-dependent mechanisms.	dss	85-88	killer cell lectin-like receptor subfamily C, member 1	Mus musculus	160-165
23512078-9	2013	For DSS, the preoperative S-100B level was the strongest independent predictor (HR 2.81, P = 0.01).	dss	4-7	S100 calcium binding protein B	Homo sapiens	26-32
24156026-9	2013	Ten-year DSS improved from 85.4% to 95.6%, and was adversely influenced by anaplastic histology (hazard ratio [HR] = 8.7; P &lt; 0.001), male gender (HR = 1.8; P = 0.001), TNM stage IV (HR = 8.4; P = 0.001), incomplete surgical resection (HR = 2.4; P = 0.002), and age at diagnosis (HR = 1.05 per year; P &lt; 0.001).	dss	9-12	teneurin transmembrane protein 1	Homo sapiens	172-175
23607276-5	2013	We found that Bcl-3(-/-) mice were less sensitive to DSS-induced colitis compared to wild-type controls and demonstrated no significant weight loss following treatment.	dss	53-56	B cell leukemia/lymphoma 3	Mus musculus	14-19
23607276-6	2013	Histological analysis revealed similar levels of oedema and leucocyte infiltration between DSS-treated wild-type and Bcl-3(-/-) mice, but showed that Bcl-3(-/-) mice retained colonic tissue architecture which was absent in wild-type mice following DSS treatment.	dss	91-94	B cell leukemia/lymphoma 3	Mus musculus	117-122
23607276-6	2013	Histological analysis revealed similar levels of oedema and leucocyte infiltration between DSS-treated wild-type and Bcl-3(-/-) mice, but showed that Bcl-3(-/-) mice retained colonic tissue architecture which was absent in wild-type mice following DSS treatment.	dss	248-251	B cell leukemia/lymphoma 3	Mus musculus	150-155
23607276-9	2013	Our results reveal that Bcl-3 has an important role in regulating intestinal epithelial cell proliferation and sensitivity to DSS-induced colitis which is distinct from its role as a negative regulator of inflammation.	dss	126-129	B cell leukemia/lymphoma 3	Mus musculus	24-29
22907805-5	2013	In patients with oropharyngeal SCC, p16 expression was associated with improved disease-specific survival (DSS), overall survival (OS), and time to recurrence (TTR) (p &lt; .01, &lt; .01, and &lt;.01, respectively).	dss	107-110	cyclin dependent kinase inhibitor 2A	Homo sapiens	36-39
22907805-6	2013	EGFR expression was associated with poorer DSS, OS, and TTR (p &lt; .01, = .01, and &lt; .01, respectively).	dss	43-46	epidermal growth factor receptor	Homo sapiens	0-4
22907805-7	2013	For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS (p p16 = .01; p EGFR = .01).	dss	173-176	serpin family B member 3	Homo sapiens	18-21
22907805-7	2013	For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS (p p16 = .01; p EGFR = .01).	dss	173-176	cyclin dependent kinase inhibitor 2A	Homo sapiens	96-99
22907805-7	2013	For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS (p p16 = .01; p EGFR = .01).	dss	173-176	epidermal growth factor receptor	Homo sapiens	128-132
22907805-7	2013	For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS (p p16 = .01; p EGFR = .01).	dss	173-176	cyclin dependent kinase inhibitor 2A	Homo sapiens	96-99
22907805-7	2013	For oropharyngeal SCC, when examining both p16 and EGFR expression as combined biomarkers, high p16 expression coupled with low EGFR expression was associated with improved DSS (p p16 = .01; p EGFR = .01).	dss	173-176	epidermal growth factor receptor	Homo sapiens	128-132
23797361-3	2013	DSS treatment caused less severe body weight loss, diminished rectal bleeding, and less diarrhea in PepT1-KO mice than in wild-type (WT) animals.	dss	0-3	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	100-105
23797361-4	2013	A histological examination of colonic sections revealed that the colonic architecture was less disrupted and the extent of immune cell infiltration into the mucosa and submucosa following DSS treatment was reduced in PepT1-KO mice compared with WT animals.	dss	188-191	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	217-222
23797361-5	2013	Consistent with these results, the DSS-induced colitis increase in colonic myeloperoxidase activity was significantly less in PepT1-KO mice than in WT littermates.	dss	35-38	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	126-131
23797361-6	2013	The colonic levels of mRNAs encoding the inflammatory cytokines CXCL1, interleukin (IL)-6, monocyte chemotactic protein-1, IL-12, and interferon-gamma were significantly lower in DSS-treated PepT1-KO mice than in DSS-treated WT animals.	dss	179-182	chemokine (C-X-C motif) ligand 1	Mus musculus	64-69
23797361-6	2013	The colonic levels of mRNAs encoding the inflammatory cytokines CXCL1, interleukin (IL)-6, monocyte chemotactic protein-1, IL-12, and interferon-gamma were significantly lower in DSS-treated PepT1-KO mice than in DSS-treated WT animals.	dss	179-182	interleukin 6	Mus musculus	71-89
23797361-6	2013	The colonic levels of mRNAs encoding the inflammatory cytokines CXCL1, interleukin (IL)-6, monocyte chemotactic protein-1, IL-12, and interferon-gamma were significantly lower in DSS-treated PepT1-KO mice than in DSS-treated WT animals.	dss	179-182	chemokine (C-C motif) ligand 2	Mus musculus	91-121
23797361-6	2013	The colonic levels of mRNAs encoding the inflammatory cytokines CXCL1, interleukin (IL)-6, monocyte chemotactic protein-1, IL-12, and interferon-gamma were significantly lower in DSS-treated PepT1-KO mice than in DSS-treated WT animals.	dss	179-182	interferon gamma	Mus musculus	134-150
23797361-6	2013	The colonic levels of mRNAs encoding the inflammatory cytokines CXCL1, interleukin (IL)-6, monocyte chemotactic protein-1, IL-12, and interferon-gamma were significantly lower in DSS-treated PepT1-KO mice than in DSS-treated WT animals.	dss	179-182	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	191-196
23922772-7	2013	Furthermore, FJX1 null mice develop significantly fewer colonic polyps than wild-type littermates after combined dextran sodium sulfate (DSS) and azoxymethane (AOM) treatment.	dss	137-140	four jointed box 1	Mus musculus	13-17
23936123-6	2013	While OVA-directed, CD4+ Foxp3+ regulatory T cells could be detected in the spleens of both OVA-treated control and DSS mice, OVA-reactive, CD4+ Foxp3-T cells were only found in the OVA and DSS-treated mice.	dss	116-119	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	6-9
23936123-6	2013	While OVA-directed, CD4+ Foxp3+ regulatory T cells could be detected in the spleens of both OVA-treated control and DSS mice, OVA-reactive, CD4+ Foxp3-T cells were only found in the OVA and DSS-treated mice.	dss	116-119	CD4 antigen	Mus musculus	20-23
23673000-6	2013	DSS treatment also enhanced the platelet aggregation response to thrombin and accelerated thrombus development in WT mice, but not in IL-6(-/-) mice.	dss	0-3	coagulation factor II	Mus musculus	65-73
23334251-13	2013	Survivin and beta-catenin expression were associated with intraperitoneal recurrence; high bcl-2 expression predicted longer DSS.	dss	125-128	BCL2 apoptosis regulator	Homo sapiens	91-96
23336970-6	2013	Kolaviron suppressed the DSS-mediated increase in colonic nitric oxide concentration and myeloperoxidase activity and significantly prevented the increase in inflammatory mediators, interleukin-1beta and tumour necrosis factor alpha, in the colon of DSS-treated rats.	dss	250-253	interleukin 1 beta	Rattus norvegicus	182-232
23336970-7	2013	The significant depletion in colonic antioxidant status in rats exposed to DSS alone was evident by marked reduction in colonic catalase and glutathione S-transferase activities as well as glutathione content, leading to elevated hydrogen peroxide and lipid peroxidation levels.	dss	75-78	hematopoietic prostaglandin D synthase	Rattus norvegicus	141-166
23430954-6	2013	Compared with Gas6(+/+) mice, Gas6(-/-) mice exhibited enhanced azoxymethane/dextran sulfate sodium (DSS)-induced tumorigenesis and had a shorter survival.	dss	101-104	growth arrest specific 6	Mus musculus	30-34
23430954-7	2013	Gas6(-/-) mice also exhibited more severe DSS-induced colitis.	dss	42-45	growth arrest specific 6	Mus musculus	0-4
23430954-8	2013	DSS-treated Gas6(-/-) mice showed attenuated Socs1/3 messenger RNA expression and enhanced nuclear factor-kappaB activation in the colonic stroma, suggesting that the target of Gas6 is stromal cells.	dss	0-3	growth arrest specific 6	Mus musculus	12-16
23430954-8	2013	DSS-treated Gas6(-/-) mice showed attenuated Socs1/3 messenger RNA expression and enhanced nuclear factor-kappaB activation in the colonic stroma, suggesting that the target of Gas6 is stromal cells.	dss	0-3	growth arrest specific 6	Mus musculus	177-181
22840351-13	2013	PSA before SC and time to recurrence were also predictive of DSS (p=0.003 and p=0.01, respectively).	dss	61-64	kallikrein related peptidase 3	Homo sapiens	0-3
22840351-14	2013	In multivariate analyses, only PSA nadir after SC was predictive of recurrence and DSS (p&lt;0.001 and p=0.012, respectively).	dss	83-86	kallikrein related peptidase 3	Homo sapiens	31-34
23337347-8	2013	However, in DSS-treated and EVOO+PE-fed mice, DAI and cell proliferation were significantly reduced, as well as MCP-1, TNF-alpha, COX-2 and iNOS expression levels.	dss	12-15	chemokine (C-C motif) ligand 2	Mus musculus	112-117
23337347-8	2013	However, in DSS-treated and EVOO+PE-fed mice, DAI and cell proliferation were significantly reduced, as well as MCP-1, TNF-alpha, COX-2 and iNOS expression levels.	dss	12-15	tumor necrosis factor	Mus musculus	119-128
23337347-8	2013	However, in DSS-treated and EVOO+PE-fed mice, DAI and cell proliferation were significantly reduced, as well as MCP-1, TNF-alpha, COX-2 and iNOS expression levels.	dss	12-15	cytochrome c oxidase II, mitochondrial	Mus musculus	130-135
23337347-8	2013	However, in DSS-treated and EVOO+PE-fed mice, DAI and cell proliferation were significantly reduced, as well as MCP-1, TNF-alpha, COX-2 and iNOS expression levels.	dss	12-15	nitric oxide synthase 2, inducible	Mus musculus	140-144
23000190-1	2013	The vitamin D system plays a critical role in inflammatory bowel disease as evidenced by the finding that both vitamin D deficient mice and vitamin D receptor knockout mice are extremely sensitive to dextran sodium sulfate (DSS)-induced colitis.	dss	224-227	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	140-158
23752130-10	2013	Our novel findings suggest that butyric acid has significant anti-inflammatory effects partly via MFG-E8 on DSS-induced murine experimental colitis.	dss	108-111	milk fat globule EGF and factor V/VIII domain containing	Mus musculus	98-104
23795660-6	2013	Moreover, this observation of miR-19a and TNF-alpha was also occurred in DSS-treated mice colitis.	dss	73-76	microRNA 19a	Mus musculus	30-37
23795660-6	2013	Moreover, this observation of miR-19a and TNF-alpha was also occurred in DSS-treated mice colitis.	dss	73-76	tumor necrosis factor	Mus musculus	42-51
23795660-9	2013	CONCLUSION: Taken together, this study determines the levels of miR-19a and TNF-alpha in both DSS-induced experimental murine colitis and human UC and further demonstrates that miR-19a might directly regulate TNF-alpha.	dss	94-97	microRNA 19a	Mus musculus	64-71
23795660-9	2013	CONCLUSION: Taken together, this study determines the levels of miR-19a and TNF-alpha in both DSS-induced experimental murine colitis and human UC and further demonstrates that miR-19a might directly regulate TNF-alpha.	dss	94-97	tumor necrosis factor	Mus musculus	76-85
23795660-9	2013	CONCLUSION: Taken together, this study determines the levels of miR-19a and TNF-alpha in both DSS-induced experimental murine colitis and human UC and further demonstrates that miR-19a might directly regulate TNF-alpha.	dss	94-97	microRNA 19a	Homo sapiens	177-184
23795660-9	2013	CONCLUSION: Taken together, this study determines the levels of miR-19a and TNF-alpha in both DSS-induced experimental murine colitis and human UC and further demonstrates that miR-19a might directly regulate TNF-alpha.	dss	94-97	tumor necrosis factor	Homo sapiens	209-218
23826144-0	2013	MicroRNA-21 knockout improve the survival rate in DSS induced fatal colitis through protecting against inflammation and tissue injury.	dss	50-53	microRNA 21a	Mus musculus	0-11
23826144-12	2013	CONCLUSION: Our results suggest that miR-21 is overexpressed in intestinal inflammation and tissue injury, while knockout of miR-21 in mice improve the survival rate in DSS-induced fatal colitis through protecting against inflammation and tissue injury.	dss	169-172	microRNA 21a	Mus musculus	125-131
22894650-6	2013	High expression of XRCC1, FEN1, and SMUG1 correlated with poor disease-specific survival (DSS) (p-values: 0.001, 0.006, and 0.05, respectively) and poor disease-free survival (DFS) (p-values: 0.001, 0.001, and 0.02, respectively).	dss	90-93	X-ray repair cross complementing 1	Homo sapiens	19-24
22894650-6	2013	High expression of XRCC1, FEN1, and SMUG1 correlated with poor disease-specific survival (DSS) (p-values: 0.001, 0.006, and 0.05, respectively) and poor disease-free survival (DFS) (p-values: 0.001, 0.001, and 0.02, respectively).	dss	90-93	flap structure-specific endonuclease 1	Homo sapiens	26-30
22894650-6	2013	High expression of XRCC1, FEN1, and SMUG1 correlated with poor disease-specific survival (DSS) (p-values: 0.001, 0.006, and 0.05, respectively) and poor disease-free survival (DFS) (p-values: 0.001, 0.001, and 0.02, respectively).	dss	90-93	single-strand-selective monofunctional uracil-DNA glycosylase 1	Homo sapiens	36-41
22894650-7	2013	Low expression of ATM correlated to lymph node positivity (p=0.03), vascular invasion (p=0.05), and perineural invasion (p=0.005) and poor DFS (p=0.001) and poor DSS (p=0.003).	dss	162-165	ATM serine/threonine kinase	Homo sapiens	18-21
23805328-6	2013	DSS treatment increased colonic mRNA expression of IL-1beta and IL-17A as well as inflammasome expression in both genotypes, but the abundance of TNFalpha was selectively increased in DSS treated Mttp-IKO mice.	dss	0-3	interleukin 1 beta	Mus musculus	51-59
23805328-6	2013	DSS treatment increased colonic mRNA expression of IL-1beta and IL-17A as well as inflammasome expression in both genotypes, but the abundance of TNFalpha was selectively increased in DSS treated Mttp-IKO mice.	dss	0-3	interleukin 17A	Mus musculus	64-70
23805328-6	2013	DSS treatment increased colonic mRNA expression of IL-1beta and IL-17A as well as inflammasome expression in both genotypes, but the abundance of TNFalpha was selectively increased in DSS treated Mttp-IKO mice.	dss	184-187	tumor necrosis factor	Mus musculus	146-154
23840500-10	2013	Finally, HMGB1, abundantly present in the feces of mice with DSS-induced colitis, is strongly reduced by DPG.	dss	61-64	high mobility group box 1	Mus musculus	9-14
23785429-5	2013	CD69(+) cells infiltrated extensively into the inflamed mucosa of the colon in WT mice after DSS treatment.	dss	93-96	CD69 antigen	Mus musculus	0-4
23785429-7	2013	The administration of an anti-CD69 antibody also inhibited the induction of the DSS-induced colitis.	dss	80-83	CD69 antigen	Mus musculus	30-34
23785429-8	2013	These results indicate that CD69 expressed on CD4 T cells plays an important role in the pathogenesis of DSS-induced acute and chronic colitis, and that CD69 could be a possible therapeutic target for colitis.	dss	105-108	CD69 antigen	Mus musculus	28-32
23785429-8	2013	These results indicate that CD69 expressed on CD4 T cells plays an important role in the pathogenesis of DSS-induced acute and chronic colitis, and that CD69 could be a possible therapeutic target for colitis.	dss	105-108	CD69 antigen	Mus musculus	153-157
23652315-5	2013	RESULTS: Membranous PODXL expression was significantly associated with more advanced tumour (T) stage and high-grade tumours in both cohorts, and a significantly reduced 5-year OS (unadjusted HR=2.25 in Cohort I and 3.10 in Cohort II, adjusted HR=2.05 in Cohort I and 2.18 in Cohort II) and DSS (unadjusted HR=4.36, adjusted HR=2.70).	dss	291-294	podocalyxin like	Homo sapiens	20-25
23652315-6	2013	In patients with Ta and T1 tumours, membranous PODXL expression was an independent predictor of a reduced 2-year PFS (unadjusted HR=6.19, adjusted HR=4.60) and DSS (unadjusted HR=8.34, adjusted HR=7.16).	dss	160-163	podocalyxin like	Homo sapiens	47-52
23776480-6	2013	In vivo CD69(-/-) CD4 T cells accumulate in the intestine in higher numbers than B6 CD4 T cells as observed in competitive homing assay, dextran sodium sulphate (DSS)-induced colitis and antigen-specific transfer colitis.	dss	162-165	CD69 antigen	Mus musculus	8-12
23776480-8	2013	Furthermore, treatment of DSS-administrated CD69(-/-) mice with the mixture of CCL-1, CXCL-10 and CCL-19 neutralizing Abs significantly decreased the histopathological signs of colitis.	dss	26-29	CD69 antigen	Mus musculus	44-48
23776480-8	2013	Furthermore, treatment of DSS-administrated CD69(-/-) mice with the mixture of CCL-1, CXCL-10 and CCL-19 neutralizing Abs significantly decreased the histopathological signs of colitis.	dss	26-29	chemokine (C-C motif) ligand 1	Mus musculus	79-84
23776480-8	2013	Furthermore, treatment of DSS-administrated CD69(-/-) mice with the mixture of CCL-1, CXCL-10 and CCL-19 neutralizing Abs significantly decreased the histopathological signs of colitis.	dss	26-29	chemokine (C-X-C motif) ligand 10	Mus musculus	86-93
23776480-8	2013	Furthermore, treatment of DSS-administrated CD69(-/-) mice with the mixture of CCL-1, CXCL-10 and CCL-19 neutralizing Abs significantly decreased the histopathological signs of colitis.	dss	26-29	chemokine (C-C motif) ligand 19	Mus musculus	98-104
23738943-5	2013	High expressions of EphA2, EphA4, and ephrinA1 were significantly associated with poorer disease-specific survival (DSS; p &lt; 0.001, p &lt; 0.001, p = 0.026).	dss	116-119	EPH receptor A2	Homo sapiens	20-25
23738943-5	2013	High expressions of EphA2, EphA4, and ephrinA1 were significantly associated with poorer disease-specific survival (DSS; p &lt; 0.001, p &lt; 0.001, p = 0.026).	dss	116-119	EPH receptor A4	Homo sapiens	27-32
23738943-5	2013	High expressions of EphA2, EphA4, and ephrinA1 were significantly associated with poorer disease-specific survival (DSS; p &lt; 0.001, p &lt; 0.001, p = 0.026).	dss	116-119	ephrin A1	Homo sapiens	38-46
23738943-6	2013	On multivariate analysis, EphA4 was an independent prognostic factor of DSS (hazard ratio [HR], 2.3; 95% confidence interval [CI], 1.1-4.8; p = 0.028), and EphA2 tended to be a prognostic factor (HR, 2.4; 95% CI, 1.0-5.8; p = 0.050).	dss	72-75	EPH receptor A4	Homo sapiens	26-31
23406733-6	2013	In contrast, in 675 non-triple-negative breast cancer patients who received adjuvant chemotherapy, BRCA1 methylation was an unfavorable predictor of DFS and DSS in univariate analysis (DFS: HR = 1.56; 95% CI 1.16-2.12; P = 0.003; DSS: HR = 1.53; 95% CI = 1.05-2.21; P = 0.026).	dss	157-160	BRCA1 DNA repair associated	Homo sapiens	99-104
23406733-6	2013	In contrast, in 675 non-triple-negative breast cancer patients who received adjuvant chemotherapy, BRCA1 methylation was an unfavorable predictor of DFS and DSS in univariate analysis (DFS: HR = 1.56; 95% CI 1.16-2.12; P = 0.003; DSS: HR = 1.53; 95% CI = 1.05-2.21; P = 0.026).	dss	230-233	BRCA1 DNA repair associated	Homo sapiens	99-104
23306855-5	2013	Moreover, in claudin-2 (-/-) mice, colitis was induced by the administration of dextran sodium sulfate (DSS).	dss	104-107	claudin 2	Mus musculus	13-22
23306855-9	2013	DSS-induced colitis was more severe in the claudin-2 (-/-) mice than in the claudin-2 (+/-) mice.	dss	0-3	claudin 2	Mus musculus	43-52
23361573-10	2013	In DSS-induced mice, OPN expression in plasma and colonic tissues increased significantly, and this increase was significantly reduced after the mice were treated with SASP and infliximab.	dss	3-6	secreted phosphoprotein 1	Mus musculus	21-24
23371012-8	2013	RESULTS: After 7 days, DSS-induced loss of body weight, increase of colitis score, shortening of colon length, pathological changes and elevated levels of TNF-alpha, IL-1beta, MDA, and MPO in colon lesions, were significantly suppressed by oral lactulose administration and intraperitoneally injected H2-rich saline.	dss	23-26	tumor necrosis factor	Mus musculus	155-164
23371012-8	2013	RESULTS: After 7 days, DSS-induced loss of body weight, increase of colitis score, shortening of colon length, pathological changes and elevated levels of TNF-alpha, IL-1beta, MDA, and MPO in colon lesions, were significantly suppressed by oral lactulose administration and intraperitoneally injected H2-rich saline.	dss	23-26	interleukin 1 beta	Mus musculus	166-174
23371012-8	2013	RESULTS: After 7 days, DSS-induced loss of body weight, increase of colitis score, shortening of colon length, pathological changes and elevated levels of TNF-alpha, IL-1beta, MDA, and MPO in colon lesions, were significantly suppressed by oral lactulose administration and intraperitoneally injected H2-rich saline.	dss	23-26	myeloperoxidase	Mus musculus	185-188
23813877-7	2013	RESULTS: The overexpression of miR-146b activated the NF-kappaB pathway, improved epithelial barrier function, relieved intestinal inflammation in the DSS-induced colitis mice, and improved the survival rate of mice with lethal colitis.	dss	151-154	microRNA 146b	Mus musculus	31-39
22751125-4	2013	In mice, SMAC deficiency significantly increased the incidence and size of colon tumors induced by azoxymethane (AOM)/dextran sulfate sodium salt (DSS), and highly enriched beta-catenin hot spot mutations.	dss	147-150	diablo, IAP-binding mitochondrial protein	Mus musculus	9-13
23546531-5	2013	The 5-year disease-specific survival (DSS) was worse for pN1 patients than for pN0 patients (46 vs. 77 %; P &lt; 0.0001).	dss	38-41	serpin family E member 2	Homo sapiens	57-60
23546531-9	2013	Among pN1 patients, a LN count &gt;12 was associated with a significantly better 5-year DSS (59 vs. 22 %; P = 0.027).	dss	88-91	serpin family E member 2	Homo sapiens	6-9
23494124-3	2013	Our previous study showed that genetic restoration of colonic epithelial PHB expression [villin-PHB transgenic (PHB Tg) mice] attenuated dextran sodium sulfate (DSS)-induced colitis/oxidative stress and sustained expression of colonic nuclear factor erythroid 2-related factor 2 (Nrf2), a cytoprotective transcription factor.	dss	161-164	prohibitin	Mus musculus	73-76
23494124-3	2013	Our previous study showed that genetic restoration of colonic epithelial PHB expression [villin-PHB transgenic (PHB Tg) mice] attenuated dextran sodium sulfate (DSS)-induced colitis/oxidative stress and sustained expression of colonic nuclear factor erythroid 2-related factor 2 (Nrf2), a cytoprotective transcription factor.	dss	161-164	prohibitin	Mus musculus	96-99
23494124-8	2013	PHB Tg/Nrf2(-/-) mice mimicked PHB Tg mice, with attenuated DSS- or TNBS-induced colitis and induction of colonic HO-1 and NQO-1 expression, despite deletion of Nrf2.	dss	60-63	prohibitin	Mus musculus	0-3
23494124-8	2013	PHB Tg/Nrf2(-/-) mice mimicked PHB Tg mice, with attenuated DSS- or TNBS-induced colitis and induction of colonic HO-1 and NQO-1 expression, despite deletion of Nrf2.	dss	60-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	7-11
23344392-12	2013	DSS was better in node-positive patients with high IDO expression.	dss	0-3	indoleamine 2,3-dioxygenase 1	Homo sapiens	51-54
23376423-6	2013	Expression of Spdef also was induced transiently by administration of tetracycline to Spdef(dox-intestine) mice with established tumors, induced by the combination of AOM and DSS or by breeding with Apc(Min/+) mice.	dss	175-178	SAM pointed domain containing ets transcription factor	Mus musculus	14-19
22980419-8	2013	A multivariate analysis showed that gender, age, and TNM stage were independent prognostic factors for the 5-year OS and DSS of NPC patients.	dss	121-124	teneurin transmembrane protein 1	Homo sapiens	53-56
23360694-6	2013	However, the presence of galectin-4, but not galectin-6, in the lamina propria of the DSS-damaged colon, its association with luminal colonic bacteria, and differences in subcellular localization of these proteins suggest that they also have distinct roles in the normal and the damaged mouse digestive tract.	dss	86-89	lectin, galactose binding, soluble 4	Mus musculus	25-35
23376423-11	2013	Likewise, Spdef(-/-) mice developed approximately 3-fold more colon tumors than Spdef(+/+) mice after administration of AOM and DSS.	dss	128-131	SAM pointed domain containing ets transcription factor	Mus musculus	10-15
23376423-12	2013	After administration of 1,2-dimethylhydrazine and DSS, invasive carcinomas were observed exclusively in Spdef(-/-) mice.	dss	50-53	SAM pointed domain containing ets transcription factor	Mus musculus	104-109
23376423-13	2013	Conversely, expression of SPDEF was sufficient to promote cell-cycle exit in cells of established adenomas from Spdef(dox-intestine); Apc(Min/+) mice and in Spdef(dox-intestine) mice after administration of AOM + DSS.	dss	213-216	SAM pointed domain containing ets transcription factor	Mus musculus	26-31
23516311-3	2013	The aim of this study was to evaluate the translational potential of noninvasive (18)F-FDG PET/CT for the assessment of mucosal damage in murine dextran sodium sulfate (DSS) colitis and human IBD.	dss	169-172	thyroid stimulating hormone receptor	Mus musculus	91-94
23384671-5	2013	RESULTS: In univariate analysis, high co-expression of CD4+ and CD8+ T lymphocytes as well as high expression of CD1a+ dendritic cells in the tumor stroma correlated with improved disease-specific survival (DSS).	dss	207-210	CD1a molecule	Homo sapiens	113-117
23684440-9	2013	In DSS-treated mice, mushroom-supplemented diets increased IL-6 and IL-23 levels (P &lt; .05).	dss	3-6	interleukin 23, alpha subunit p19	Mus musculus	68-73
23577872-2	2013	However, the precise source of IL-1beta producing cells in DSS colitis is currently not known.	dss	59-62	interleukin 1 beta	Mus musculus	31-39
23399699-10	2013	SIGNIFICANCE: 6-TG and CsA are suitable reference compounds in the DSS mouse model.	dss	67-70	excision repaiross-complementing rodent repair deficiency, complementation group 8	Mus musculus	23-26
23565664-7	2013	Negative RBM3 expression was associated with a significantly shorter DSS (HR=2.55; 95% CI 1.68-3.86)) and 5-year OS (HR=2.10; 95% CI 1.56-2.82), also in multivariable analysis (HR=1.65; 95% CI 1.07-2.53 for DSS and HR=1.54; 95% CI 1.13-2.10 for 5-year OS).	dss	69-72	RNA binding motif protein 3	Homo sapiens	9-13
23565664-7	2013	Negative RBM3 expression was associated with a significantly shorter DSS (HR=2.55; 95% CI 1.68-3.86)) and 5-year OS (HR=2.10; 95% CI 1.56-2.82), also in multivariable analysis (HR=1.65; 95% CI 1.07-2.53 for DSS and HR=1.54; 95% CI 1.13-2.10 for 5-year OS).	dss	207-210	RNA binding motif protein 3	Homo sapiens	9-13
23369702-5	2013	We compared the DSS between LDLR-negative and LDLR-positive patients.	dss	16-19	low density lipoprotein receptor	Homo sapiens	28-32
23596210-7	2013	In comparison with wild-type mice, Dextran Sodium Sulfate (DSS)-treated TRPM8 knockout mice showed elevated colonic levels of the inflammatory neuropeptide calcitonin-gene-related peptide, although inflammatory indices were equivalent for both groups.	dss	59-62	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	72-77
23359049-8	2013	The DSS benefit with BCT compared with mastectomy was greater among women age &gt;= 50 with HR-positive disease (hazard ratio = 0.86, 95% CI = 0.82-0.91) than among women age &lt; 50 with HR-negative disease (hazard ratio = 0.88, 95% CI = 0.79-0.98); however, this trend was seen among all subgroups analyzed.	dss	4-7	nuclear receptor subfamily 4 group A member 1	Homo sapiens	92-94
23369702-7	2013	RESULTS: The median DSS was higher in LDLR-negative than in LDLR-positive patients (4 (1-7) and 2 (0-5); P = 0.017).	dss	20-23	low density lipoprotein receptor	Homo sapiens	38-42
23369702-7	2013	RESULTS: The median DSS was higher in LDLR-negative than in LDLR-positive patients (4 (1-7) and 2 (0-5); P = 0.017).	dss	20-23	low density lipoprotein receptor	Homo sapiens	60-64
23369702-8	2013	After adjustment for risk factors, LDLR-negative mutational status remained an independent predictor of the DSS (B = 1.09; P = 0.047).	dss	108-111	low density lipoprotein receptor	Homo sapiens	35-39
23369702-9	2013	The DSS in the LDLR-positive group was similar for patients with identified and patients with unidentified mutational status.	dss	4-7	low density lipoprotein receptor	Homo sapiens	15-19
22442160-6	2013	Furthermore, DSS-exposed Ctsk(-/-) mice were treated by rectal administration of recombinant cathepsin K.	dss	13-16	cathepsin K	Mus musculus	25-29
22442160-6	2013	Furthermore, DSS-exposed Ctsk(-/-) mice were treated by rectal administration of recombinant cathepsin K.	dss	13-16	cathepsin K	Mus musculus	93-104
22442160-11	2013	Rectal administration of recombinant cathepsin K in DSS-treated Ctsk(-/-) mice ameliorates the severity of intestinal inflammation.	dss	52-55	cathepsin K	Mus musculus	37-48
22442160-11	2013	Rectal administration of recombinant cathepsin K in DSS-treated Ctsk(-/-) mice ameliorates the severity of intestinal inflammation.	dss	52-55	cathepsin K	Mus musculus	64-68
23341363-9	2013	High expression of Pinx1 correlated positively with ESCC"s resistance to CRT, and was a strong and independent predictor for short disease-specific survival (DSS) of ESCC patients.	dss	158-161	PIN2 (TERF1) interacting telomerase inhibitor 1	Homo sapiens	19-24
23667372-8	2013	Based on univariate analyses, BCL9 expression showed an unfavorable influence on both disease-free survival (DFS, p=0.012) and disease-specific survival (DSS, p=0.032).	dss	154-157	BCL9 transcription coactivator	Homo sapiens	30-34
23667374-9	2013	Furthermore, pRb-inactivated cases showed better DSS (p=0.023), and p53-positive cases showed worse DSS (p=0.001).	dss	49-52	RB transcriptional corepressor 1	Homo sapiens	13-16
23667374-9	2013	Furthermore, pRb-inactivated cases showed better DSS (p=0.023), and p53-positive cases showed worse DSS (p=0.001).	dss	100-103	tumor protein p53	Homo sapiens	68-71
23179399-8	2013	In univariate (Kaplan-Meier) survival analysis, positive MUC2 significantly predicted longer disease-free survival (DFS) and disease-specific survival (DSS) as well.	dss	152-155	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	57-61
23179399-9	2013	However, in multivariate (Cox) survival analysis, MUC2 lost its power as an independent predictor of DFS and DSS.	dss	109-112	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	50-54
23414694-12	2013	Kaplan-Meier analysis of DSS and OS demonstrated significant improvement in group 2 (+CRN) vs group 1 vs group 2 (no-CRN; P &lt;.001), which remained significant on multivariate regression.	dss	25-28	crooked neck pre-mRNA splicing factor 1	Homo sapiens	86-89
23414694-15	2013	Responders to primary sunitinib who underwent CRN had better DSS and OS than patients who underwent primary CRN, followed by sunitinib.	dss	61-64	crooked neck pre-mRNA splicing factor 1	Homo sapiens	46-49
23531103-11	2013	Univariate Kaplan-Meier analysis indicated increased expression of BDNF or decreased expression of BMPR1A was associated with decreased disease specific survival (DSS) rates.	dss	163-166	brain derived neurotrophic factor	Homo sapiens	67-71
23531103-11	2013	Univariate Kaplan-Meier analysis indicated increased expression of BDNF or decreased expression of BMPR1A was associated with decreased disease specific survival (DSS) rates.	dss	163-166	bone morphogenetic protein receptor type 1A	Homo sapiens	99-105
23531103-12	2013	Similarly, multivariate Cox regression analysis showed increased expression of BDNF or decreased expression of BMPR1A are independent predictors of poor DSS rates in gallbladder adenocarcinoma.	dss	153-156	brain derived neurotrophic factor	Homo sapiens	79-83
23531103-12	2013	Similarly, multivariate Cox regression analysis showed increased expression of BDNF or decreased expression of BMPR1A are independent predictors of poor DSS rates in gallbladder adenocarcinoma.	dss	153-156	bone morphogenetic protein receptor type 1A	Homo sapiens	111-117
23497154-8	2013	RESULTS: In univariate analyses, high tumor expression of Skp2 correlated (p = 0.050) with reduced disease-specific survival (DSS).	dss	126-129	S-phase kinase associated protein 2	Homo sapiens	58-62
23497154-9	2013	In subgroup analyses expression of PGR in males (p = 0.010) and in patients older than 60 years (p = 0.043) were negative prognostic factors for DSS.	dss	145-148	progesterone receptor	Homo sapiens	35-38
23497154-10	2013	Expression of ER in females was a positive prognostic factor for DSS (p = 0.041).	dss	65-68	estrogen receptor 1	Homo sapiens	14-16
23497154-11	2013	In co-expression analyses in the whole cohort, low expression of Skp2 in combination with low expression of ER was positive for DSS (p = 0.049).	dss	128-131	S-phase kinase associated protein 2	Homo sapiens	65-69
23497154-11	2013	In co-expression analyses in the whole cohort, low expression of Skp2 in combination with low expression of ER was positive for DSS (p = 0.049).	dss	128-131	estrogen receptor 1	Homo sapiens	108-110
23497154-14	2013	In females expression of Skp2 (p = 0.006) was associated with shorter DSS.	dss	70-73	S-phase kinase associated protein 2	Homo sapiens	25-29
23497154-16	2013	In men, but not women, ER positive / PGR negative co-expression profile was an independent negative prognostic factor for DSS.	dss	122-125	estrogen receptor 1	Homo sapiens	23-25
23497154-16	2013	In men, but not women, ER positive / PGR negative co-expression profile was an independent negative prognostic factor for DSS.	dss	122-125	progesterone receptor	Homo sapiens	37-40
23497154-17	2013	In women, but not men, high expression of Skp2 was associated with reduced DSS.	dss	75-78	S-phase kinase associated protein 2	Homo sapiens	42-46
23278407-7	2013	Normalization of blood pressure by nifedipine attenuated the increase in nNOS activity in the brain stem of DSS rats.	dss	108-111	nitric oxide synthase 1	Rattus norvegicus	73-77
23278407-1	2013	The aims of the present study were to determine the mechanism underlying enhanced neuronal nitric oxide synthase (nNOS) activity in the brain of hypertensive Dahl salt-sensitive (DSS) rats and the consequences of enhanced nNOS activity.	dss	179-182	nitric oxide synthase 1	Rattus norvegicus	114-118
23278407-10	2013	Feeding of a high-salt diet increased nNOS-positive neurons in the lateral parabrachial nucleus, rostral ventrolateral medulla and nucleus tractus solitarius of DSS compared with Sprague-Dawley rats, whereas nNOS-positive neurons in the paraventricular nucleus remained downregulated in DSS rats.	dss	161-164	nitric oxide synthase 1	Rattus norvegicus	38-42
23278407-11	2013	The results of the present study suggest that hypertension, rather than a high-salt diet, increases central nNOS activity in hypertensive DSS rats to buffer high blood pressure.	dss	138-141	nitric oxide synthase 1	Rattus norvegicus	108-112
23429443-1	2013	BACKGROUND: Intestinal epithelial cell (IEC) STAT3 is required for wound healing following acute dextran sodium sulfate (DSS) injury.	dss	121-124	signal transducer and activator of transcription 3	Mus musculus	45-50
23180017-4	2013	RESULTS: Among the 5 polymorphisms, PPP1R13L rs1970764 was significantly associated with relapse-free (RFS) and disease-specific survival (DSS) in a recessive model.	dss	139-142	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	36-44
23180017-6	2013	In the multivariate analysis, the GG genotype of PPP1R13L rs1970764 was identified as an independent prognostic factor for poor RFS and DSS (HR = 1.743 and 1.734; P = 0.003 and 0.010, respectively) when compared with the combine AA/AG genotype adjusted to clinicopathologic variables.	dss	136-139	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	49-57
23180017-7	2013	In particular, the prognostic impact of PPP1R13L rs1970764 was persistent only in patients with rectal cancer (HR = 3.307 and 3.180; both P &lt; 0.001 for RFS and DSS, respectively).	dss	163-166	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	40-48
23381627-3	2013	This study was to explore the roles of WIN55 and p38/Mk2 signaling pathway in dextran sodium sulfate (DSS)-induced mouse colitis and ascertain their anti-inflammatory mechanisms.	dss	102-105	mitogen-activated protein kinase 14	Mus musculus	49-52
23381627-3	2013	This study was to explore the roles of WIN55 and p38/Mk2 signaling pathway in dextran sodium sulfate (DSS)-induced mouse colitis and ascertain their anti-inflammatory mechanisms.	dss	102-105	MAP kinase-activated protein kinase 2	Mus musculus	53-56
23381627-9	2013	The results indicate that the Mk2 homozygous deletion in mice impedes the induction of experimental colitis by DSS, confirming the notion that p38/Mk2 is involved in this inflammatory response.	dss	111-114	MAP kinase-activated protein kinase 2	Mus musculus	30-33
23381627-9	2013	The results indicate that the Mk2 homozygous deletion in mice impedes the induction of experimental colitis by DSS, confirming the notion that p38/Mk2 is involved in this inflammatory response.	dss	111-114	mitogen-activated protein kinase 14	Mus musculus	143-146
23429443-11	2013	CONCLUSIONS: Loss of intestinal epithelial STAT3 leads to more severe chronic inflammation following acute injury, which is not accounted for by a sustained defect in epithelial proliferation or apoptosis 7 or 21 days after 1 cycle of DSS but rather defective REG3 expression and expansion of pSTAT3* lymphocytes and IL-17A expression.	dss	235-238	signal transducer and activator of transcription 3	Mus musculus	43-48
23374458-9	2013	Tumoral GGH protein expression was significantly correlated with shorter DSS and RFS.	dss	73-76	gamma-glutamyl hydrolase	Homo sapiens	8-11
23374458-11	2013	Multivariate regression analysis showed that only GGH protein expression independently predicts DSS.	dss	96-99	gamma-glutamyl hydrolase	Homo sapiens	50-53
23282137-11	2013	Multivariate Cox regression analysis specified that CCNB2 protein expression is an independent prognostic marker of DSS in breast cancer.	dss	116-119	cyclin B2	Homo sapiens	52-57
22878618-16	2013	NF1-associated and sporadic MPNSTs may be associated with improved DSS compared with RT-induced tumors.	dss	67-70	neurofibromin 1	Homo sapiens	0-3
22924972-9	2013	CONCLUSIONS AND IMPLICATIONS: Pharmacological inhibition of C5a activity by PMX205 is efficacious in preventing DSS-induced colitis, providing further evidence that targeting CD88 in IBD patients could be a valuable therapeutic option.	dss	112-115	complement C5a receptor 1	Homo sapiens	60-63
23089881-2	2013	In this study, we investigated the effects of cell deformability and fibrinogen concentration on disaggregating shear stress (DSS).	dss	126-129	fibrinogen beta chain	Homo sapiens	69-79
23325885-4	2013	Dextran sodium sulfate (DSS), at doses that resulted in little epithelial damage and mucosal ulceration in wild type mice, caused marked colon ulceration and delayed ulcer healing in GM-CSF(-/-) mice.	dss	24-27	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	183-189
23325885-5	2013	Colon crypt epithelial cell proliferation in vivo was significantly decreased in GM-CSF(-/-) mice at early times after DSS injury.	dss	119-122	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	81-87
23325885-8	2013	Nonhematopoietic cells, and not myeloid cells, produced the GM-CSF important for colon epithelial proliferation after DSS-induced injury, as revealed by bone marrow chimera and dendritic cell-depletion experiments, with colon epithelial cells being the cellular source of GM-CSF.	dss	118-121	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	60-66
23089881-6	2013	The effect of cell deformability on DSS was significantly increased with an increase in fibrinogen concentration (2~6 g/L).	dss	36-39	fibrinogen beta chain	Homo sapiens	88-98
23089881-7	2013	These results imply that reduced cell deformability and increased fibrinogen levels play a synergistic role in increasing DSS, which could be used as a novel independent hemorheological index to characterize microcirculatory diseases, such as diabetic complications with high sensitivity.	dss	122-125	fibrinogen beta chain	Homo sapiens	66-76
23041326-8	2013	IL-8 was strongly up-regulated on systemic or local inflammatory stimulation, increasing mobilization of immature CD11b(+)Gr-1(+) myeloid cells (IMCs) with thioglycolate-induced peritonitis, DSS-induced colitis, and H. felis-induced gastritis.	dss	191-194	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
23259573-9	2012	Importantly, HuR cytoplasmic expression was strongly associated with a worse DSS (p &lt; 0.0001), MeFS (p &lt; 0.0001), and UBRFS (p = 0.0370) in the univariate analysis, and the first two results remained independently predictive of adverse outcomes (p = 0.038, relative risk [RR] = 1.996 for DSS; p = 0.027, RR = 1.880 for MeFS).	dss	77-80	ELAV like RNA binding protein 1	Homo sapiens	13-16
23304436-4	2013	In acute colitis induced by dextran sodium sulfate (DSS), Vim KO mice develop significantly less gut inflammation than do WT mice.	dss	52-55	vimentin	Mus musculus	58-61
23304436-5	2013	Further, Vim KO mice have markedly decreased bacterial extravasation in the setting of DSS-induced acute colitis, consistent with decreased intestinal disease.	dss	87-90	vimentin	Mus musculus	9-12
23259573-9	2012	Importantly, HuR cytoplasmic expression was strongly associated with a worse DSS (p &lt; 0.0001), MeFS (p &lt; 0.0001), and UBRFS (p = 0.0370) in the univariate analysis, and the first two results remained independently predictive of adverse outcomes (p = 0.038, relative risk [RR] = 1.996 for DSS; p = 0.027, RR = 1.880 for MeFS).	dss	294-297	ELAV like RNA binding protein 1	Homo sapiens	13-16
23259573-10	2012	Cyclin A nuclear expression was associated with a poor DSS (p = 0.0035) and MeFS (p = 0.0015) in the univariate analysis but was not prognosticatory in the multivariate analyses.	dss	55-58	cyclin A2	Homo sapiens	0-8
23259573-11	2012	High-risk patients (pT3 or pT4 with/without nodal metastasis) with high HuR cytoplasmic expression had better DSS if adjuvant chemotherapy was performed (p = 0.015).	dss	110-113	ELAV like RNA binding protein 1	Homo sapiens	72-75
23259573-12	2012	CONCLUSIONS: HuR cytoplasmic expression was correlated with adverse phenotypes and cyclin A overexpression and also independently predictive of worse DSS and MeFS, suggesting its roles in tumorigenesis or carcinogenesis and potentiality as a prognostic marker of UTUC.	dss	150-153	ELAV like RNA binding protein 1	Homo sapiens	13-16
23000912-4	2012	The induction phases with DSS were characterized by severe disease activity with massive colonic polymorphonuclear infiltration and increased levels of tumor necrosis factor-alpha (TNF-alpha), keratinocyte-derived chemokine (CXCL1/KC), interleukin (IL)-17 and vascular adhesion molecule-1 (VCAM-1).	dss	26-29	tumor necrosis factor	Mus musculus	152-179
23227960-4	2012	RESULTS: Median biochemical recurrence free (BRFS), disease specific (DSS) and overall survival (OS) for patients with PSA progression during primary HT was found to be only 21, 54 and 53 months, respectively, with a 6-year BRFS, DSS and OS of 19%, 41% and 26%.	dss	70-73	kallikrein related peptidase 3	Homo sapiens	119-122
23227960-4	2012	RESULTS: Median biochemical recurrence free (BRFS), disease specific (DSS) and overall survival (OS) for patients with PSA progression during primary HT was found to be only 21, 54 and 53 months, respectively, with a 6-year BRFS, DSS and OS of 19%, 41% and 26%.	dss	230-233	kallikrein related peptidase 3	Homo sapiens	119-122
23000912-4	2012	The induction phases with DSS were characterized by severe disease activity with massive colonic polymorphonuclear infiltration and increased levels of tumor necrosis factor-alpha (TNF-alpha), keratinocyte-derived chemokine (CXCL1/KC), interleukin (IL)-17 and vascular adhesion molecule-1 (VCAM-1).	dss	26-29	tumor necrosis factor	Mus musculus	181-190
23000912-4	2012	The induction phases with DSS were characterized by severe disease activity with massive colonic polymorphonuclear infiltration and increased levels of tumor necrosis factor-alpha (TNF-alpha), keratinocyte-derived chemokine (CXCL1/KC), interleukin (IL)-17 and vascular adhesion molecule-1 (VCAM-1).	dss	26-29	chemokine (C-X-C motif) ligand 1	Mus musculus	225-230
23000912-4	2012	The induction phases with DSS were characterized by severe disease activity with massive colonic polymorphonuclear infiltration and increased levels of tumor necrosis factor-alpha (TNF-alpha), keratinocyte-derived chemokine (CXCL1/KC), interleukin (IL)-17 and vascular adhesion molecule-1 (VCAM-1).	dss	26-29	interleukin 17A	Mus musculus	236-255
23000912-4	2012	The induction phases with DSS were characterized by severe disease activity with massive colonic polymorphonuclear infiltration and increased levels of tumor necrosis factor-alpha (TNF-alpha), keratinocyte-derived chemokine (CXCL1/KC), interleukin (IL)-17 and vascular adhesion molecule-1 (VCAM-1).	dss	26-29	vascular cell adhesion molecule 1	Mus musculus	260-288
23000912-4	2012	The induction phases with DSS were characterized by severe disease activity with massive colonic polymorphonuclear infiltration and increased levels of tumor necrosis factor-alpha (TNF-alpha), keratinocyte-derived chemokine (CXCL1/KC), interleukin (IL)-17 and vascular adhesion molecule-1 (VCAM-1).	dss	26-29	vascular cell adhesion molecule 1	Mus musculus	290-296
23046361-6	2012	Here we use a large cohort of patients receiving radiotherapy to successfully validate the importance of MRE11 as a predictive marker of disease-specific survival (DSS).	dss	164-167	MRE11 homolog, double strand break repair nuclease	Homo sapiens	105-110
23046361-7	2012	Furthermore, using two independent patient cohorts we show for the first time that TIP60 is a predictive marker of DSS after cystectomy.	dss	115-118	lysine acetyltransferase 5	Homo sapiens	83-88
23046361-12	2012	RESULTS:   TIP60 was significantly correlated with DSS in both cystectomy cohorts (hazard ratio [HR] 0.42, 95% confidence interval [CI] 0.26-0.68, P &lt; 0.001 and HR 0.45, 95% CI 0.28-0.72, P = 0.001).	dss	51-54	lysine acetyltransferase 5	Homo sapiens	11-16
23046361-13	2012	MRE11 was significantly correlated with DSS in the cohort receiving radiotherapy (HR 0.64, 95% CI 0.47-0.86, P = 0.005).	dss	40-43	MRE11 homolog, double strand break repair nuclease	Homo sapiens	0-5
23046361-14	2012	P16 was significantly correlated with DSS in all three cohorts (HR 0.46, 95% CI 0.30-0.75, P = 0.032; HR 0.60, 95% CI 0.37-0.97, P = 0.032; HR 0.52, 95% CI 0.28-0.96, P = 0.001).	dss	38-41	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
23046361-17	2012	CONCLUSIONS:   TIP60 protein expression was a predictive marker for DSS after cystectomy in two independent cohorts.	dss	68-71	lysine acetyltransferase 5	Homo sapiens	15-20
23046361-19	2012	MRE11 was shown to be a predictive marker for DSS after radiotherapy.	dss	46-49	MRE11 homolog, double strand break repair nuclease	Homo sapiens	0-5
22488198-8	2012	These results demonstrate for the first time that ERbeta provides protection in the AOM/DSS-induced CAC model in mice, suggesting a preventive and/or therapeutic potential for the use of ERbeta-selective agonists in IBD.	dss	88-91	estrogen receptor 2 (beta)	Mus musculus	50-56
23117395-2	2012	Here we found that T-cell Ig mucin-3 (Tim-3) and its ligand, galectin 9 (Gal-9), were significantly decreased in UC patients and in mice with dextran sodium sulfate (DSS)-induced colitis compared to controls.	dss	166-169	hepatitis A virus cellular receptor 2	Homo sapiens	19-36
23117395-2	2012	Here we found that T-cell Ig mucin-3 (Tim-3) and its ligand, galectin 9 (Gal-9), were significantly decreased in UC patients and in mice with dextran sodium sulfate (DSS)-induced colitis compared to controls.	dss	166-169	hepatitis A virus cellular receptor 2	Homo sapiens	38-43
23117395-2	2012	Here we found that T-cell Ig mucin-3 (Tim-3) and its ligand, galectin 9 (Gal-9), were significantly decreased in UC patients and in mice with dextran sodium sulfate (DSS)-induced colitis compared to controls.	dss	166-169	galectin 9	Homo sapiens	61-71
23117395-2	2012	Here we found that T-cell Ig mucin-3 (Tim-3) and its ligand, galectin 9 (Gal-9), were significantly decreased in UC patients and in mice with dextran sodium sulfate (DSS)-induced colitis compared to controls.	dss	166-169	galectin 9	Homo sapiens	73-78
23117395-5	2012	Finally, administration of a putative antagonistic anti-Tim-3 antibody or of recombinant Gal-9 significantly exacerbated or attenuated DSS-induced colitis by altering the balance between different Th cell subsets.	dss	135-138	hepatitis A virus cellular receptor 2	Mus musculus	56-61
23117395-5	2012	Finally, administration of a putative antagonistic anti-Tim-3 antibody or of recombinant Gal-9 significantly exacerbated or attenuated DSS-induced colitis by altering the balance between different Th cell subsets.	dss	135-138	lectin, galactose binding, soluble 9	Mus musculus	89-94
23365358-7	2012	Expressed as percentage of the CON, DSS treatment decreased (P &lt; 0.05) the maximal specific activities of IAP (53%), lactase (78%), maltase (56%), SI (72%), MGA (29%), and APN (22%) as well as the target hydrolase protein abundances of IAP (39%), lactase (35%), SI (36%), and APN (54%), respectively.	dss	36-39	alkaline phosphatase, intestinal	Homo sapiens	109-112
23365358-7	2012	Expressed as percentage of the CON, DSS treatment decreased (P &lt; 0.05) the maximal specific activities of IAP (53%), lactase (78%), maltase (56%), SI (72%), MGA (29%), and APN (22%) as well as the target hydrolase protein abundances of IAP (39%), lactase (35%), SI (36%), and APN (54%), respectively.	dss	36-39	lactase	Homo sapiens	120-127
23365358-7	2012	Expressed as percentage of the CON, DSS treatment decreased (P &lt; 0.05) the maximal specific activities of IAP (53%), lactase (78%), maltase (56%), SI (72%), MGA (29%), and APN (22%) as well as the target hydrolase protein abundances of IAP (39%), lactase (35%), SI (36%), and APN (54%), respectively.	dss	36-39	maltase-glucoamylase	Homo sapiens	160-163
23365358-7	2012	Expressed as percentage of the CON, DSS treatment decreased (P &lt; 0.05) the maximal specific activities of IAP (53%), lactase (78%), maltase (56%), SI (72%), MGA (29%), and APN (22%) as well as the target hydrolase protein abundances of IAP (39%), lactase (35%), SI (36%), and APN (54%), respectively.	dss	36-39	alanyl aminopeptidase, membrane	Homo sapiens	175-178
23365358-7	2012	Expressed as percentage of the CON, DSS treatment decreased (P &lt; 0.05) the maximal specific activities of IAP (53%), lactase (78%), maltase (56%), SI (72%), MGA (29%), and APN (22%) as well as the target hydrolase protein abundances of IAP (39%), lactase (35%), SI (36%), and APN (54%), respectively.	dss	36-39	alkaline phosphatase, intestinal	Homo sapiens	239-242
23365358-7	2012	Expressed as percentage of the CON, DSS treatment decreased (P &lt; 0.05) the maximal specific activities of IAP (53%), lactase (78%), maltase (56%), SI (72%), MGA (29%), and APN (22%) as well as the target hydrolase protein abundances of IAP (39%), lactase (35%), SI (36%), and APN (54%), respectively.	dss	36-39	lactase	Homo sapiens	250-257
23365358-7	2012	Expressed as percentage of the CON, DSS treatment decreased (P &lt; 0.05) the maximal specific activities of IAP (53%), lactase (78%), maltase (56%), SI (72%), MGA (29%), and APN (22%) as well as the target hydrolase protein abundances of IAP (39%), lactase (35%), SI (36%), and APN (54%), respectively.	dss	36-39	alanyl aminopeptidase, membrane	Homo sapiens	279-282
23365358-8	2012	Decreases (P &lt; 0.05) in the mRNA abundances (% of the CON) for lactase (25%), SI (52%), MGA (75%), and APN (39%) were observed in the DSS group.	dss	137-140	lactase	Homo sapiens	66-73
23365358-8	2012	Decreases (P &lt; 0.05) in the mRNA abundances (% of the CON) for lactase (25%), SI (52%), MGA (75%), and APN (39%) were observed in the DSS group.	dss	137-140	maltase-glucoamylase	Homo sapiens	91-94
23365358-8	2012	Decreases (P &lt; 0.05) in the mRNA abundances (% of the CON) for lactase (25%), SI (52%), MGA (75%), and APN (39%) were observed in the DSS group.	dss	137-140	alanyl aminopeptidase, membrane	Homo sapiens	106-109
23365358-9	2012	However, DSS treatment increased (P &lt; 0.05) the jejunal IAP mRNA abundance by 3.5 fold.	dss	9-12	alkaline phosphatase, intestinal	Homo sapiens	59-62
22987085-10	2012	In multivariable models that included number of metastatic lymph nodes, grade, tumor stage, and polysomy 17, only HER2 heterogeneity and node number were prognostic among HER2-amplified tumors, with heterogeneity showing worse DSS (hazard ratio, 2.04; 95% CI, 1.09 to 3.79; P = .025) and OS (P = .026).	dss	227-230	erb-b2 receptor tyrosine kinase 2	Homo sapiens	171-175
22948780-7	2012	Significantly higher serum TK1 levels were found in patients with advanced disease (p &lt; 0.0001) and TK1 levels also correlated with disease-specific survival (DSS, p &lt; 0.07).	dss	162-165	thymidine kinase 1	Homo sapiens	103-106
22572638-2	2012	Here, we report that dextran sodium sulfate (DSS)-induced colitis is accompanied by major shifts in the composition and function of the intestinal microbiota of STAT1(-/-) and wild-type mice, as determined by 454 pyrosequencing of bacterial 16S rRNA (gene) amplicons, metatranscriptomics and quantitative fluorescence in situ hybridization of selected phylotypes.	dss	45-48	signal transducer and activator of transcription 1	Mus musculus	161-166
23022186-3	2012	We here showed that RORgammat(+)IL-22(+) ILC22 cells were localized in Thy-1(high)SCA-1(high) and/or Thy-1(high)SCA-1(low) subpopulations of the intestine in normal and dextran sodium sulfate (DSS)-induced colitic RORgammat-sufficient Rag-2(-/-) mice.	dss	193-196	interleukin 22	Mus musculus	32-37
23022186-4	2012	RORgammat-deficient Rag-2(-/-) mice developed more severe DSS-induced colitis accompanied with lower expression of REG3beta and REG3gamma in the colon, but with a lower ratio and absolute number of IFN-gamma-producing ILC1 cells as compared to control RORgammat-sufficient Rag-2(-/-) mice.	dss	58-61	recombination activating gene 2	Mus musculus	20-25
22374925-9	2012	Serum LRG levels were increased in IL-6-deficient mice with LPS-mediated acute inflammation and DSS-induced colitis.	dss	96-99	leucine-rich alpha-2-glycoprotein 1	Mus musculus	6-9
22374925-9	2012	Serum LRG levels were increased in IL-6-deficient mice with LPS-mediated acute inflammation and DSS-induced colitis.	dss	96-99	interleukin 6	Mus musculus	35-39
22572638-2	2012	Here, we report that dextran sodium sulfate (DSS)-induced colitis is accompanied by major shifts in the composition and function of the intestinal microbiota of STAT1(-/-) and wild-type mice, as determined by 454 pyrosequencing of bacterial 16S rRNA (gene) amplicons, metatranscriptomics and quantitative fluorescence in situ hybridization of selected phylotypes.	dss	45-48	DNA segment, 16S	Mus musculus	241-244
22572638-4	2012	Comparative 16S rRNA sequence analysis at maximum possible phylogenetic resolution identified several indicator phylotypes for DSS treatment, including the putative mucin degraders Akkermansia and Mucispirillum.	dss	127-130	DNA segment, 16S	Mus musculus	12-15
23012474-6	2012	Conversely, the early lineages of B and T cells declined in the marrow and thymus with particularly large losses observed among pre-B and pre-T cells with heightened levels of apoptosis noted among CD4(+)CD8(+) thymocytes from DSS-treated mice.	dss	227-230	CD4 antigen	Mus musculus	198-201
23070952-5	2012	METHODS: We analyzed the expression of RelA, A20, pIgR, tumor necrosis factor (TNF), and macrophage inflammatory protein (MIP)-2 in CEC of mice with dextran sodium sulfate (DSS) acute colitis or T-cell-mediated chronic colitis.	dss	173-176	chemokine (C-X-C motif) ligand 2	Mus musculus	89-128
23070952-9	2012	Disease severity was correlated with elevated PC2 scores in DSS colitis and reduced PC1 scores in T-cell transfer colitis.	dss	60-63	minisatellite 6 hypermutable 3	Mus musculus	46-49
23174583-7	2012	The expression of miR-19a was lowered following DSS treatment, and Baitouweng Decoction treatment caused an increased miR-19a expression in DSS-treated mice.	dss	48-51	microRNA 19a	Mus musculus	18-25
23174583-7	2012	The expression of miR-19a was lowered following DSS treatment, and Baitouweng Decoction treatment caused an increased miR-19a expression in DSS-treated mice.	dss	140-143	microRNA 19a	Mus musculus	18-25
23174583-7	2012	The expression of miR-19a was lowered following DSS treatment, and Baitouweng Decoction treatment caused an increased miR-19a expression in DSS-treated mice.	dss	140-143	microRNA 19a	Mus musculus	118-125
23174583-8	2012	CONCLUSION: Baitouweng Decoction has therapeutic effects on DSS-induced ulcerative colitis in mice, and this effect is probably mediated by enhancement of miR-19a expression in the intestines.	dss	60-63	microRNA 19a	Mus musculus	155-162
22419609-4	2012	The effect of HIP/PAP on dextran sodium sulfate (DSS)-induced colitis was assessed by disease activity index (DAI), macroscopic, and histological evaluations.	dss	49-52	regenerating family member 3 beta	Rattus norvegicus	14-21
22419609-9	2012	RESULTS: The protective effect of HIP/PAP against DSS-induced colitis in rats was confirmed.	dss	50-53	regenerating family member 3 beta	Rattus norvegicus	34-41
22419609-12	2012	CONCLUSIONS: HIP/PAP has a protective effect against DSS-induced colitis in rats via inhibiting inflammation, alleviating oxidative damage, and promoting colonic epithelium regeneration.	dss	53-56	regenerating family member 3 beta	Rattus norvegicus	13-20
22508383-6	2012	Animals were treated with IL-33 between the DSS cycles (intermediate treatment) or after onset of chronic disease (posttreatment).	dss	44-47	interleukin 33	Mus musculus	26-31
22508383-11	2012	CONCLUSIONS: In summary, IL-33 has extenuating effects in chronic DSS-induced colitis: Excessive Th1-directed cytokine responses are shifted toward Th2-like immune reactions and general inflammation parameters are reduced.	dss	66-69	interleukin 33	Mus musculus	25-30
22508383-11	2012	CONCLUSIONS: In summary, IL-33 has extenuating effects in chronic DSS-induced colitis: Excessive Th1-directed cytokine responses are shifted toward Th2-like immune reactions and general inflammation parameters are reduced.	dss	66-69	negative elongation factor complex member C/D, Th1l	Mus musculus	97-100
22213390-4	2012	Deletion polymorphism of GSTM1 gene was significantly associated with DSS.	dss	70-73	glutathione S-transferase mu 1	Homo sapiens	25-30
22722030-1	2012	In the current study, we investigated the effect of the activation of the alpha-7 nicotinic acetylcholine receptor (alpha7 nAchR) on dextran sulphate sodium (DSS)-induced colitis and referred mechanical hyperalgesia in mice.	dss	158-161	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	74-114
22722030-1	2012	In the current study, we investigated the effect of the activation of the alpha-7 nicotinic acetylcholine receptor (alpha7 nAchR) on dextran sulphate sodium (DSS)-induced colitis and referred mechanical hyperalgesia in mice.	dss	158-161	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	116-128
22722030-2	2012	Colitis was induced in CD1 male mice through the intake of 4% DSS in tap water for 7 days.	dss	62-65	CD1 antigen complex	Mus musculus	23-26
22836084-0	2012	Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa.	dss	33-36	interleukin 17A	Homo sapiens	68-74
22836084-6	2012	Our results demonstrate that IL-12p40 delivery ameliorates DSS-induced colitis by suppressing IL-17A production and inflammation in the intestinal mucosa, providing an effective new therapeutic strategy for IBDs.	dss	59-62	interleukin 17A	Homo sapiens	94-100
21997551-6	2012	Dextran sodium sulphate (DSS) was administered to PKR (double-stranded-RNA-activated protein kinase) knockout mice to induce IEC stress in vivo and to test for their susceptibility to DSS-induced colitis.	dss	25-28	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	50-53
21997551-10	2012	Pkr(-/-) mice failed to induce CPN60 in IECs upon DSS treatment at early time points and subsequently showed an almost complete resistance to DSS-induced colitis.	dss	142-145	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	0-3
23342897-17	2012	In a univariate analysis a significantly shorter disease free survival (DFS) and disease specific survival (DSS) was noted in patients with metastases to the lymph nodes (p = 0.003 and p = 0.0006), over the age of 50 years old ((p = 0.02 and p = 0.04) and clearly statistically significant in patients with a high expression of BCRP (p = 0.00044 and p = 0.00005).	dss	108-111	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	328-332
23342897-19	2012	A multivariate analysis allowed to reveal that only higher expression of BCRP and metastases to lymph nodes were typical for cases of DFS (p = 0.,028 and p = 0.00015), DSS (p = 0.00052 and 0.000017) and OS (p = 0.0018 and p = 0.000007) time.	dss	168-171	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-77
22275310-6	2012	RESULTS: PKR(-/-) mice displayed more severe clinical and histological manifestations upon DSS colitis compared with their PKR(+/+,+/-) littermates.	dss	91-94	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	9-12
22275310-7	2012	In response to DSS colitis, the colonic epithelial cells of PKR(-/-) mice exhibited impaired activation of the unfolded protein response (UPR) signaling, including eIF2alpha phosphorylation, endoplasmic reticulum (ER) chaperone response, and ER-associated degradation (ERAD) components, as well as antioxidative stress response.	dss	15-18	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	60-63
22275310-7	2012	In response to DSS colitis, the colonic epithelial cells of PKR(-/-) mice exhibited impaired activation of the unfolded protein response (UPR) signaling, including eIF2alpha phosphorylation, endoplasmic reticulum (ER) chaperone response, and ER-associated degradation (ERAD) components, as well as antioxidative stress response.	dss	15-18	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	164-173
22791769-6	2012	In multivariate analyses, low CDK2AP1 expression emerged as an independent prognosticator for worse disease-specific survival (DSS; p=0.037) and local recurrence-free survival (LRFS; p=0.042), along with AJCC stage III-IV (p=0.034, DSS; p=0.029, LRFS).	dss	127-130	cyclin dependent kinase 2 associated protein 1	Homo sapiens	30-37
22791769-6	2012	In multivariate analyses, low CDK2AP1 expression emerged as an independent prognosticator for worse disease-specific survival (DSS; p=0.037) and local recurrence-free survival (LRFS; p=0.042), along with AJCC stage III-IV (p=0.034, DSS; p=0.029, LRFS).	dss	232-235	cyclin dependent kinase 2 associated protein 1	Homo sapiens	30-37
22909126-7	2012	However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-alpha, IL-1beta and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p &lt; 0.05).	dss	38-41	signal transducer and activator of transcription 3	Mus musculus	185-190
22909126-7	2012	However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-alpha, IL-1beta and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p &lt; 0.05).	dss	38-41	interleukin 6	Mus musculus	210-214
22909126-7	2012	However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-alpha, IL-1beta and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p &lt; 0.05).	dss	38-41	tumor necrosis factor	Mus musculus	216-225
22909126-7	2012	However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-alpha, IL-1beta and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p &lt; 0.05).	dss	38-41	interleukin 1 beta	Mus musculus	227-235
22909126-7	2012	However, the clinical symptoms of the DSS-treated APNKO mice were worse than WT mice treated with DSS and had increased susceptibility to intestinal inflammation due to increased local STAT3 activation, higher IL-6, TNF-alpha, IL-1beta and IL-10 levels, and as a result had increased intestinal epithelial cell proliferation (p &lt; 0.05).	dss	38-41	interleukin 10	Mus musculus	240-245
22909126-9	2012	Exercise was also found to significantly decrease the phosphorylation expression of STAT3 in both WT and APNKO mice in DSS + EX group when compared to DSS + SED.	dss	119-122	signal transducer and activator of transcription 3	Mus musculus	84-89
22476749-5	2012	Gene status and protein expression of CDK6 were correlated with each other, clinicopathological variables, metastasis-free survival (MFS), and disease-specific survival (DSS).	dss	170-173	cyclin dependent kinase 6	Homo sapiens	38-42
22750333-4	2012	DSS treatment resulted in the ablation of Lgr5(+) stem cells in the distal colon, concurrent with the loss of distal crypt structure and proliferating cells.	dss	0-3	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	42-46
22750333-6	2012	Lgr5(+) stem cells reappeared at day 5 of DSS recovery, with normal levels attained by day 6 of recovery.	dss	42-45	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	0-4
22750333-10	2012	These results indicate that rapidly cycling Lgr5(+) stem cells residing at position 1 in the colon epithelium are highly susceptible to DSS-induced damage and that dietary cues can impact stem cell regulatory networks.	dss	136-139	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	44-48
22476749-8	2012	Importantly, CDK6 protein overexpression (MFS, p = .0002; DSS, p = .0015) and gene amplification (MFS, p = .0001; DSS, p = .0083) were both univariately associated with worse outcomes.	dss	58-61	cyclin dependent kinase 6	Homo sapiens	13-17
22476749-8	2012	Importantly, CDK6 protein overexpression (MFS, p = .0002; DSS, p = .0015) and gene amplification (MFS, p = .0001; DSS, p = .0083) were both univariately associated with worse outcomes.	dss	114-117	cyclin dependent kinase 6	Homo sapiens	13-17
21969131-10	2012	It was observed that the 5-year DSS for patients who provided specimens with high and low expression of CD133 was 90 and 71%, respectively (P = 0.003).	dss	32-35	prominin 1	Homo sapiens	104-109
22852863-12	2012	Only Bax expression associated with disease-specific survival (DSS), with 5-year survival estimates of 85.7% for high Bax versus 50.3% for low Bax (p = 0.006), in univariate analysis.	dss	63-66	BCL2 associated X, apoptosis regulator	Homo sapiens	5-8
22852863-12	2012	Only Bax expression associated with disease-specific survival (DSS), with 5-year survival estimates of 85.7% for high Bax versus 50.3% for low Bax (p = 0.006), in univariate analysis.	dss	63-66	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
22852863-12	2012	Only Bax expression associated with disease-specific survival (DSS), with 5-year survival estimates of 85.7% for high Bax versus 50.3% for low Bax (p = 0.006), in univariate analysis.	dss	63-66	BCL2 associated X, apoptosis regulator	Homo sapiens	118-121
22852863-14	2012	In multivariate analyses, Bax protein expression remained an independent predictor of DSS in OSCC [HR 0.241 (0.078-0.745), p = 0.013].	dss	86-89	BCL2 associated X, apoptosis regulator	Homo sapiens	26-29
22297864-8	2012	The histological score of intestinal inflammation in 2% dextran sodium sulfate (DSS)-treated mice with the administration of 10 nM CSF was significantly lower than that of control mice.	dss	80-83	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	131-134
22297864-9	2012	CSF also improved the survival rate of mice treated with a lethal concentration of DSS.	dss	83-86	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	0-3
22595989-0	2012	Expression of TNFAIP3 in intestinal epithelial cells protects from DSS- but not TNBS-induced colitis.	dss	67-70	tumor necrosis factor, alpha-induced protein 3	Mus musculus	14-21
22595989-6	2012	Villin-TNFAIP3 Tg mice were protected from DSS-induced colitis and displayed reduced production of NF-kappaB-dependent inflammatory cytokines.	dss	43-46	tumor necrosis factor, alpha-induced protein 3	Mus musculus	7-14
22595989-7	2012	Villin-TNFAIP3 Tg mice were also protected from DSS-induced increases in intestinal permeability and induction of IEC death.	dss	48-51	tumor necrosis factor, alpha-induced protein 3	Mus musculus	7-14
22595989-9	2012	These results indicate that TNFAIP3 expression in IEC prevents colitis involving DSS-induced IEC death, but not colitis driven by T cell-mediated inflammation.	dss	81-84	tumor necrosis factor, alpha-induced protein 3	Mus musculus	28-35
22273853-6	2012	When comparing different TNM categories between well-differentiated PTC and FTC, no statistically significant differences were found but PDTCs, had a significantly worse DSS.	dss	170-173	teneurin transmembrane protein 1	Homo sapiens	25-28
22716209-11	2012	A sub-group analysis revealed that E-cadherin expression also predicts DFS (p &lt; 0.01) and DSS (p &lt; 0.04) in stage II CRC.	dss	93-96	cadherin 1	Homo sapiens	35-45
22716210-7	2012	Patients who exhibited c-Src expression demonstrated poor progression-free survival (PFS) (p = 0.044) and disease-specific survival (DSS) (p = 0.017).	dss	133-136	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	23-28
22716210-8	2012	Subgroup analysis demonstrated that c-Src positive patients exhibited significantly worse bone metastasis-free survival (p = 0.027) and DSS (p = 0.024), whereas in patients with non-bone metastasis no significant difference was observed in PFS (p = 0.819) and DSS (p = 0.381).	dss	136-139	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-41
22716210-8	2012	Subgroup analysis demonstrated that c-Src positive patients exhibited significantly worse bone metastasis-free survival (p = 0.027) and DSS (p = 0.024), whereas in patients with non-bone metastasis no significant difference was observed in PFS (p = 0.819) and DSS (p = 0.381).	dss	260-263	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	36-41
22716210-9	2012	Multivariate analysis demonstrated that c-Src expression was an independent predictor of DSS for patients with bone metastasis.	dss	89-92	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	40-45
22273853-7	2012	CONCLUSIONS: The current TNM system is a sufficient tool for predicting DSS in well-differentiated PTC.	dss	72-75	teneurin transmembrane protein 1	Homo sapiens	25-28
22419056-7	2012	RESULTS: Co-administration of NO during DSS exposure inhibited the induction of an increasing colonic MPO-activity.	dss	40-43	myeloperoxidase	Mus musculus	102-105
21637966-10	2012	Neither p27 nor p21 did predict disease-specific survival (DSS) in Kaplan-Meier analysis, but DSS time was much shorter for p27-positive tumors.	dss	94-97	interferon alpha inducible protein 27	Homo sapiens	124-127
22081509-4	2012	Matriptase function was investigated by subjecting St14 hypomorphic and control littermates to dextran sodium sulfate (DSS)-induced colitis and by siRNA silencing in cultured monolayers.	dss	119-122	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	0-10
22081509-7	2012	Matriptase-deficient St14 hypomorphic mice administered DSS for 7 days followed by water without DSS for 3 days develop a severe colitis, with only 30% of the St14 hypomorphic mice surviving to day 14, compared with 100% of control littermates.	dss	56-59	suppression of tumorigenicity 14 (colon carcinoma)	Mus musculus	21-25
22700475-12	2012	Enema with AAV-BMP-7 significantly ameliorated DSS-induced colitis as indicated by reduced DAI, decreased macroscopic and histological scores and declined MPO activity compared to the controls.	dss	47-50	bone morphogenetic protein 7	Rattus norvegicus	11-20
22700475-14	2012	AAV-BMP-7 significantly prevented oxidant damage and attenuated complementary mucosal cell proliferation in the DSS-treated rat colons.	dss	112-115	bone morphogenetic protein 7	Rattus norvegicus	0-9
22700475-16	2012	administration of AAV-BMP-7 efficiently mediates the ectopic BMP-7 expression in rat colon and further ameliorates DSS-induced UC in rats, suggesting that i.c.	dss	115-118	bone morphogenetic protein 7	Rattus norvegicus	18-27
22700475-16	2012	administration of AAV-BMP-7 efficiently mediates the ectopic BMP-7 expression in rat colon and further ameliorates DSS-induced UC in rats, suggesting that i.c.	dss	115-118	bone morphogenetic protein 7	Rattus norvegicus	22-27
22326557-4	2012	METHODS: Expression of CDX2 and MEP1A was investigated in colonic biopsies of ulcerative colitis (UC) patients and in dextran sodium sulfate (DSS)-induced colitis.	dss	142-145	caudal type homeobox 2	Homo sapiens	23-27
22326557-4	2012	METHODS: Expression of CDX2 and MEP1A was investigated in colonic biopsies of ulcerative colitis (UC) patients and in dextran sodium sulfate (DSS)-induced colitis.	dss	142-145	meprin A subunit alpha	Homo sapiens	32-37
22322660-6	2012	DSS-treated mice received either TNF-alpha ab or Control ab on days 4 and 8 of colitis, while non-colitic Control mice received injections of TNF-alpha ab (Control + TNF-alpha ab).	dss	0-3	tumor necrosis factor	Mus musculus	33-42
22550081-2	2012	The present study shows reduced inflammatory responses and colorectal cancer in IEX-1 knockout (KO) mice treated with azoxymethane/dextran sulfate sodium (DSS).	dss	155-158	immediate early response 3	Mus musculus	80-85
22550081-3	2012	However, DSS induced worse colitis in RAG(-/-)IEX-1(-/-) double KO mice than in RAG and IEX-1 single KO mice, underscoring an importance of T cells in IEX-1 deficiency-induced protection against colon inflammation.	dss	9-12	immediate early response 3	Mus musculus	46-51
22550081-5	2012	In accordance with this, T-helper 17 (T(H)17) cell differentiation was compromised in the absence of Galphai2, and deletion of Galphai2 in T cells alone aggravated colon inflammation and colorectal cancer development after azoxymethane/DSS treatment.	dss	236-239	guanine nucleotide binding protein (G protein), alpha inhibiting 2	Mus musculus	127-135
22471242-10	2012	Combined positivity for BRAF and extra-nodal extension was much stronger in predicting disease specific survival (DSS) (p=0.004) than the single analysis of BRAF (p=0.12) or extra-nodal extension (p=0.02).	dss	114-117	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	24-28
22471242-12	2012	(ii) Combined positivity for BRAF and extra-nodal extension has additive prognostic value in predicting DSS.	dss	104-107	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	29-33
22554285-7	2012	RESULTS: In univariate analyses increased expression of M-CSF (P = 0.034), Ki67 (P &lt; 0.001) and TGF-beta (P = 0.003) in tumor correlated with shorter disease-specific survival (DSS).	dss	180-183	colony stimulating factor 1	Homo sapiens	56-61
22323434-6	2012	RESULTS: Patients with tumors that were strongly positive for cyclin D1 and FADD had reduced overall (OS; P = .003 and P &lt; .001), disease-specific (DSS; P = .039 and P &lt; .001), and disease-free (DFS; P = .026 and P &lt; .001) survival, respectively.	dss	151-154	cyclin D1	Homo sapiens	62-71
22323434-6	2012	RESULTS: Patients with tumors that were strongly positive for cyclin D1 and FADD had reduced overall (OS; P = .003 and P &lt; .001), disease-specific (DSS; P = .039 and P &lt; .001), and disease-free (DFS; P = .026 and P &lt; .001) survival, respectively.	dss	151-154	Fas associated via death domain	Homo sapiens	76-80
22323434-9	2012	Using Cox regression analysis, FADD and N stage were significant independent predictors of DSS and DFS, whereas cyclin D1, FADD, and N stage were independently significant for OS.	dss	91-94	Fas associated via death domain	Homo sapiens	31-35
22421620-4	2012	Serpin B1 mRNA expression was determined by real-time PCR in the mouse dextran sodium sulfate (DSS)-induced colitis model.	dss	95-98	serpin family B member 1	Homo sapiens	0-9
22421620-11	2012	Serpin B1 mRNA expression was also increased in colonic mucosa of mouse DSS-induced colitis.	dss	72-75	serpin family B member 1	Homo sapiens	0-9
22422705-7	2012	Those treated with DSS developed watery diarrhea and bloody stools, and showed body weight loss, spleen hypertrophy, and shortening of the colon, as well as deteriorations in survival rate, liver function, colon mucosal interleukin-1beta level and expression of phase II detoxification enzyme mRNA.	dss	19-22	interleukin 1 beta	Mus musculus	220-237
22554285-7	2012	RESULTS: In univariate analyses increased expression of M-CSF (P = 0.034), Ki67 (P &lt; 0.001) and TGF-beta (P = 0.003) in tumor correlated with shorter disease-specific survival (DSS).	dss	180-183	transforming growth factor beta 1	Homo sapiens	99-107
22969974-10	2012	CD44 expression remained an independent prognostic factor for DSS (P=0.002).	dss	62-65	CD44 molecule (Indian blood group)	Homo sapiens	0-4
21953855-12	2012	CONCLUSIONS: Imiquimod induces type I IFN and AMP to ameliorate DSS-induced acute colitis and prevents Salmonella survival.	dss	64-67	interferon alpha 1	Homo sapiens	38-41
22337474-2	2012	We aimed to compare the efficacy of Dead Sea salt (DSS) irrigations and DSS nasal spray vs saline irrigations and topical nasal steroid spray in the treatment of symptoms of CRS.	dss	51-54	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	41-44
22246420-10	2012	CONCLUSIONS: The protective effects of SI-IELs in DSS-induced colitis were partly accomplished by gammadelta T cells and could be mediated by TGF-beta but were not associated with IFN-gamma.	dss	50-53	transforming growth factor, beta 1	Mus musculus	142-150
21658926-7	2012	In the small intestine, although mucosa histology was similar among groups, DSS treatment reduced duodenal transforming growth factor-beta, increased interleukin-10 concentrations and increased memory T lymphocytes and dendritic cells in Peyer"s patches.	dss	76-79	interleukin 10	Mus musculus	150-164
22323126-7	2012	AOM-DSS mice treated with vehicle or hGly(2)GLP-2 had high-grade dysplasia/colon cancer incidences of 56 and 64%, respectively, compared with 46% in hGLP-2(3-33)-treated AOM-DSS animals (P &lt; 0.05).	dss	4-7	glucagon-like peptide 2 receptor	Mus musculus	44-49
22323126-7	2012	AOM-DSS mice treated with vehicle or hGly(2)GLP-2 had high-grade dysplasia/colon cancer incidences of 56 and 64%, respectively, compared with 46% in hGLP-2(3-33)-treated AOM-DSS animals (P &lt; 0.05).	dss	174-177	glucagon-like peptide 2 receptor	Mus musculus	44-49
22529697-8	2012	CD44s positivity and PTEN LIs &gt;= 50% correlated with higher DSS in gastric GIST.	dss	63-66	CD44 molecule (Indian blood group)	Homo sapiens	0-4
22529697-8	2012	CD44s positivity and PTEN LIs &gt;= 50% correlated with higher DSS in gastric GIST.	dss	63-66	phosphatase and tensin homolog	Homo sapiens	21-25
22492389-8	2012	In multivariate analyses, loss of EMP2 expression emerged as an independent prognosticator for worse disease-specific survival (DSS; p=0.015) and local recurrence-free survival (LRFS; p=0.030), along with the American Joint Committee on Cancer stages III-IV (p=0.034, DSS; p=0.023, LRFS).	dss	128-131	epithelial membrane protein 2	Homo sapiens	34-38
22492389-8	2012	In multivariate analyses, loss of EMP2 expression emerged as an independent prognosticator for worse disease-specific survival (DSS; p=0.015) and local recurrence-free survival (LRFS; p=0.030), along with the American Joint Committee on Cancer stages III-IV (p=0.034, DSS; p=0.023, LRFS).	dss	268-271	epithelial membrane protein 2	Homo sapiens	34-38
22322146-3	2012	With 0.2gbeta-CDg(-1) dried solids (DSs), the increment rate for VFAs peaked at 4200gg(-1)DSsg(-1) beta-CD, with acetate and propionate as the predominant VFAs.	dss	36-39	phosphomannomutase 2	Homo sapiens	14-20
22293630-7	2012	Furthermore, terminal deoxynucleotidyl transferase-mediated dUTP nick end labeling (TUNEL) labeling of inflammatory cells within the colonic mesenteric lymph nodes was elevated in mice consuming DSS + the hexane fraction of American ginseng.	dss	195-198	deoxynucleotidyltransferase, terminal	Mus musculus	13-50
21602260-1	2012	BACKGROUND: A recent study demonstrated that an increased number of CD68+ macrophages were correlated with primary treatment failure, shortened progression-free survival (PFS) and disease-specific survival (DSS) in patients with classical Hodgkin"s lymphoma (cHL).	dss	207-210	CD68 molecule	Homo sapiens	68-72
21861229-11	2012	Tumor size &gt;= 5 cm, high tumor grade, tumor location, presence of neurofibromatosis type 1, local recurrence, and adjuvant chemotherapy were all associated with DSS.	dss	164-167	neurofibromin 1	Homo sapiens	69-93
22081787-8	2012	In multivariate analyses, Rsf-1 overexpression not only emerged as the sole independent adverse prognosticator for LRFS (p=0.0002, RR 5.287) but also independently predicted worse DMFS (p=0.0011, RR 3.185) and DSS (p&lt;0.0001, RR 4.442), along with T(3,4) (p=0.0454) and N(2,3) (p=0.0319), respectively.	dss	210-213	remodeling and spacing factor 1	Homo sapiens	26-31
22120983-6	2012	PN7d/DSS mice showed increased intestinal permeability and elevated portal vein LPS levels, evidence of hepatocyte injury and cholestasis (serum aspartate aminotransferase, alanine aminotransferase, bile acids, total bilirubin), and increased KC expression of interleukin-6 (Il6), tumor necrosis factor alpha (Tnfalpha), and transforming growth factor beta (Tgfbeta).	dss	5-8	interleukin 6	Mus musculus	260-273
22120983-6	2012	PN7d/DSS mice showed increased intestinal permeability and elevated portal vein LPS levels, evidence of hepatocyte injury and cholestasis (serum aspartate aminotransferase, alanine aminotransferase, bile acids, total bilirubin), and increased KC expression of interleukin-6 (Il6), tumor necrosis factor alpha (Tnfalpha), and transforming growth factor beta (Tgfbeta).	dss	5-8	interleukin 6	Mus musculus	275-278
22120983-6	2012	PN7d/DSS mice showed increased intestinal permeability and elevated portal vein LPS levels, evidence of hepatocyte injury and cholestasis (serum aspartate aminotransferase, alanine aminotransferase, bile acids, total bilirubin), and increased KC expression of interleukin-6 (Il6), tumor necrosis factor alpha (Tnfalpha), and transforming growth factor beta (Tgfbeta).	dss	5-8	tumor necrosis factor	Mus musculus	281-308
22120983-6	2012	PN7d/DSS mice showed increased intestinal permeability and elevated portal vein LPS levels, evidence of hepatocyte injury and cholestasis (serum aspartate aminotransferase, alanine aminotransferase, bile acids, total bilirubin), and increased KC expression of interleukin-6 (Il6), tumor necrosis factor alpha (Tnfalpha), and transforming growth factor beta (Tgfbeta).	dss	5-8	tumor necrosis factor	Mus musculus	310-318
22120983-6	2012	PN7d/DSS mice showed increased intestinal permeability and elevated portal vein LPS levels, evidence of hepatocyte injury and cholestasis (serum aspartate aminotransferase, alanine aminotransferase, bile acids, total bilirubin), and increased KC expression of interleukin-6 (Il6), tumor necrosis factor alpha (Tnfalpha), and transforming growth factor beta (Tgfbeta).	dss	5-8	transforming growth factor, beta 1	Mus musculus	358-365
22120983-9	2012	Suppression of the intestinal microbiota with broad spectrum antibiotics or ablation of TLR4 signaling in Tlr4 mutant mice resulted in significantly reduced KC activation and markedly attenuated liver injury in PN7d/DSS mice.	dss	216-219	toll-like receptor 4	Mus musculus	88-92
22120983-9	2012	Suppression of the intestinal microbiota with broad spectrum antibiotics or ablation of TLR4 signaling in Tlr4 mutant mice resulted in significantly reduced KC activation and markedly attenuated liver injury in PN7d/DSS mice.	dss	216-219	toll-like receptor 4	Mus musculus	106-110
22080974-11	2012	In contrast to WT and CGRP(-/-) mice, SP(-/-) and RTX-desensitized mice showed amelioration of DSS colitis accompanied by a loss of the proximodistal gradient of inflammation.	dss	95-98	tachykinin 1	Mus musculus	38-40
21871020-7	2012	RESULTS: Compared with wild-type littermates, UCP-2(-/-) mice treated with DSS developed more severe diarrhea, body weight loss (P &lt; 0.01), significantly short colon length, and more inflammatory cell infiltration into the mucosa and submucosa.	dss	75-78	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	46-51
21871020-8	2012	The level of malondialdehyde in colonic mucosa increased in UCP-2(-/-) mice treated with DSS compared with the wild-type littermates (P &lt; 0.001).	dss	89-92	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	60-65
22466883-2	2012	In the present study, we observed a decrease in pIgR in colon lysate from mice with dextran sodium sulfate (DSS) colitis.	dss	108-111	polymeric immunoglobulin receptor	Mus musculus	48-52
22466883-8	2012	Furthermore, we found that expressions of IFN-gamma and TNF-alpha were higher in DSS colitis.	dss	81-84	interferon gamma	Mus musculus	42-51
22466883-8	2012	Furthermore, we found that expressions of IFN-gamma and TNF-alpha were higher in DSS colitis.	dss	81-84	tumor necrosis factor	Mus musculus	56-65
22466883-10	2012	In sum, our findings show that pIgR levels vary according to the severity of DSS colitis and that these changes might be useful as a biomarker of the severity of inflammatory bowel disease.	dss	77-80	polymeric immunoglobulin receptor	Mus musculus	31-35
21932407-6	2012	RESULT: The 5-year disease specific survival (DSS) rate of patients with high p-4E-BP1 expression was significantly lower than that of patients with lower p-4E-BP1 expression (5 year DSS: 58% vs. 8.6%, P = 0.00064).	dss	46-49	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	80-86
21932407-7	2012	Furthermore, in a multivariate analysis by Cox regression model, high p-4E-BP1 expression was confirmed to be an independent prognostic factor (HR: 2.269; unfavorable, P = 0.024) for DSS, while lymph node (HR: 3.016; unfavorable, P = 0.005) was also significant prognostic factor.	dss	183-186	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	72-78
26781733-7	2012	DSS-induced colitis appeared to induce significant increase in MPO activity, levels of TNF-alpha, IL-6 and IFN-gamma.	dss	0-3	myeloperoxidase	Mus musculus	63-66
22740953-6	2012	However, patients with the PIK3CA mutation and/or high methylation (2 or 3 methylated genes) had significantly poorer outcomes in disease-specific survival (DSS) compared with those with wild-type PIK3CA and 0 or 1 methylated genes (P=0.0059).	dss	157-160	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	27-33
22740953-7	2012	Additionally, multivariate analysis revealed that the PIK3CA mutation and/or a high level of methylation predicts a poor DSS independently of clinicopathological characteristics.	dss	121-124	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	54-60
26781733-7	2012	DSS-induced colitis appeared to induce significant increase in MPO activity, levels of TNF-alpha, IL-6 and IFN-gamma.	dss	0-3	tumor necrosis factor	Mus musculus	87-96
26781733-7	2012	DSS-induced colitis appeared to induce significant increase in MPO activity, levels of TNF-alpha, IL-6 and IFN-gamma.	dss	0-3	interleukin 6	Mus musculus	98-102
26781733-7	2012	DSS-induced colitis appeared to induce significant increase in MPO activity, levels of TNF-alpha, IL-6 and IFN-gamma.	dss	0-3	interferon gamma	Mus musculus	107-116
22138299-5	2012	In the dextran sodium sulfate (DSS) and adoptive T-cell transfer models, there was proximal migration of colonic inflammation, worsened patchy intestinal inflammation, and long gross intestinal strictures in Tl1a transgenic compared to wild-type littermates.	dss	31-34	tumor necrosis factor (ligand) superfamily, member 15	Mus musculus	208-212
22160616-4	2012	Multivariate analysis of the total group showed that CD30 negativity, folliculotropic MF, extent of skin lesions and extracutaneous transformation were associated with reduced disease-specific survival (DSS) and, except for CD30 negativity and folliculotropic MF, also overall survival.	dss	203-206	TNF receptor superfamily member 8	Homo sapiens	53-57
22160616-5	2012	In a multivariate analysis of 75 patients with only skin lesions at the time of LCT, CD30 negativity, folliculotropic MF and extent of skin lesions were independent parameters for both DSS and overall survival.	dss	185-188	TNF receptor superfamily member 8	Homo sapiens	85-89
22138299-6	2012	In the DSS model, myeloid- and T-cell-expressing Tl1a transgenic mice had increased T-cell activation markers and interleukin-17 expression compared to wild-type mice.	dss	7-10	tumor necrosis factor (ligand) superfamily, member 15	Mus musculus	49-53
21901260-4	2012	Epithelial cell lines were used to assess the levels of poly (ADP-ribose) polymerase (PARP) in the presence of 2.0% DSS in vitro.	dss	116-119	poly (ADP-ribose) polymerase family, member 1	Mus musculus	56-84
21901260-4	2012	Epithelial cell lines were used to assess the levels of poly (ADP-ribose) polymerase (PARP) in the presence of 2.0% DSS in vitro.	dss	116-119	poly (ADP-ribose) polymerase family, member 1	Mus musculus	86-90
21901260-6	2012	RESULTS: In vitro experiments using CaCo-2 and CMT-93 cells revealed decreased PARP levels from all DSS preparations.	dss	100-103	poly (ADP-ribose) polymerase family, member 1	Mus musculus	79-83
21901260-7	2012	Notably, the PARP level was significantly decreased in CaCo-2 cells treated with DSS from USB as compared to The Lab Mice treated with The Lab DSS had significantly decreased body weight losses on day 7 as compared to mice receiving DSS from MP Bio and USB.	dss	81-84	poly(ADP-ribose) polymerase 1	Homo sapiens	13-17
21901260-7	2012	Notably, the PARP level was significantly decreased in CaCo-2 cells treated with DSS from USB as compared to The Lab Mice treated with The Lab DSS had significantly decreased body weight losses on day 7 as compared to mice receiving DSS from MP Bio and USB.	dss	143-146	poly(ADP-ribose) polymerase 1	Homo sapiens	13-17
21901260-7	2012	Notably, the PARP level was significantly decreased in CaCo-2 cells treated with DSS from USB as compared to The Lab Mice treated with The Lab DSS had significantly decreased body weight losses on day 7 as compared to mice receiving DSS from MP Bio and USB.	dss	143-146	poly(ADP-ribose) polymerase 1	Homo sapiens	13-17
21300475-5	2012	EZH2 immunolabeling was assessable for 89 primary NPC biopsy samples and correlated with clinicopathological variables, disease-specific survival (DSS), and overall survival (OS).	dss	147-150	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	0-4
22009715-0	2012	P-selectin glycoprotein ligand-1 is needed for sequential recruitment of T-helper 1 (Th1) and local generation of Th17 T cells in dextran sodium sulfate (DSS) colitis.	dss	154-157	selectin, platelet (p-selectin) ligand	Mus musculus	0-32
22009715-9	2012	RESULTS: DSS colitis increases CD4+ T cells in colonic tissue and induces Th1 (interferon gamma [IFN-gamma], tumor necrosis factor [TNF]) and Th17 (interleukin [IL]-17, IL-22) cytokines.	dss	9-12	CD4 antigen	Mus musculus	31-34
22009715-9	2012	RESULTS: DSS colitis increases CD4+ T cells in colonic tissue and induces Th1 (interferon gamma [IFN-gamma], tumor necrosis factor [TNF]) and Th17 (interleukin [IL]-17, IL-22) cytokines.	dss	9-12	interleukin 22	Mus musculus	169-174
21300475-8	2012	As a continuous variable, higher EZH2 expression preferentially occurred in NPCs of T3 to T4 stages (p = 0.03) and significantly predicted inferior DSS (p = 0.0010) and OS (p = 0.004).	dss	148-151	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	33-37
21300475-9	2012	The prognostic implications for DSS (p = 0.010) and OS (p = 0.006) still remained valid when using the median (&gt;= 60%) of EZH2 immunolabeling index to dichotomize the cohort.	dss	32-35	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	125-129
21300475-10	2012	In the multivariate model, higher EZH2 expression was an independent adverse factor of both DSS (p = 0.012) and OS (p = 0.011), along with American Joint Committee on Cancer Stages III to IV (p = 0.024 for DSS, p = 0.017 for OS).	dss	92-95	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-38
21300475-10	2012	In the multivariate model, higher EZH2 expression was an independent adverse factor of both DSS (p = 0.012) and OS (p = 0.011), along with American Joint Committee on Cancer Stages III to IV (p = 0.024 for DSS, p = 0.017 for OS).	dss	206-209	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	34-38
22044934-0	2012	Functionally enhanced siRNA targeting TNFalpha attenuates DSS-induced colitis and TLR-mediated immunostimulation in mice.	dss	58-61	tumor necrosis factor	Mus musculus	38-46
22252257-11	2012	In EACs with BE, HER2 positivity was significantly associated with improved DSS [HR = 0.54 (95% CI: 0.35-0.84), P = 0.0065] and overall survival (P = 0.0022) independent of pathologic features, but was not prognostic among EACs without BE.	dss	76-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
22740938-12	2012	Univariate analyses revealed that Fuhrman nuclear grade and a high IL-32 expression were significant prognostic factors for predicting RFS, DSS and OS in CCRCC, whereas multivariate analyses indicated that Fuhrman nuclear grade and high IL-32 expression were still independent risk factors.	dss	140-143	interleukin 32	Homo sapiens	67-72
22740938-13	2012	In conclusion, IL-32 overexpression was associated with high recurrence rates and low RFS, DSS and OS, indicating that it may be a novel prognostic factor for predicting outcomes in patients with CCRCC.	dss	91-94	interleukin 32	Homo sapiens	15-20
22252257-10	2012	Among all cases, HER2 positivity was significantly associated with disease-specific survival (DSS) in a manner that differed by the presence or absence of BE (P(interaction) = 0.0047).	dss	94-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
23075517-8	2012	The 5-year DSS rate for patients with a p53 mutation was 84.4%, compared with 97.1% for patients without.	dss	11-14	tumor protein p53	Homo sapiens	40-43
23075874-3	2012	Previously, we reported that the uptake of dextran sodium sulfate (DSS) by macrophages activates the Nlrp3 inflammasome and that Nlrp3(-/-) mice are protected in the acute DSS colitis model.	dss	67-70	NLR family, pyrin domain containing 3	Mus musculus	101-106
23075874-3	2012	Previously, we reported that the uptake of dextran sodium sulfate (DSS) by macrophages activates the Nlrp3 inflammasome and that Nlrp3(-/-) mice are protected in the acute DSS colitis model.	dss	172-175	NLR family, pyrin domain containing 3	Mus musculus	129-134
23075874-4	2012	Of note, other groups have reported opposing effects in regards to DSS susceptibility in Nlrp3(-/-) mice.	dss	67-70	NLR family, pyrin domain containing 3	Mus musculus	89-94
23075874-8	2012	RESULTS: Nlrp3(-/-) mice treated with either DSS or TNBS exhibited attenuated colitis and lower mortality.	dss	45-48	NLR family, pyrin domain containing 3	Mus musculus	9-14
22093175-11	2012	The CPI-17 phosphorylation was equally suppressed in both normal and DSS conditions by Go6976 and chelerythrine, but only for the phasic component of contraction.	dss	69-72	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	4-10
22192184-10	2012	Production of proinflammatory cytokines was decreased and that of the antiinflammatory cytokine IL-10 was increased in the DSS-treated mice given Lb.	dss	123-126	interleukin 10	Mus musculus	96-101
23118901-12	2012	GLT treatment also significantly down-regulated PhIP/DSS-dependent expression of cyclin D1, COX-2, CYP1A2 and CYP3A4 in colon tissue.	dss	53-56	cyclin D1	Mus musculus	81-90
22183632-10	2012	Even after adjusting for HPV status, we found that CD8, FoxP3, and total T cells were significantly associated with DSS (P=.0236, P=.0040, and P=.0197, respectively) and OS (P=.0137, P=.0158, and P=.0115, respectively).	dss	116-119	CD8a molecule	Homo sapiens	51-54
22183632-10	2012	Even after adjusting for HPV status, we found that CD8, FoxP3, and total T cells were significantly associated with DSS (P=.0236, P=.0040, and P=.0197, respectively) and OS (P=.0137, P=.0158, and P=.0115, respectively).	dss	116-119	forkhead box P3	Homo sapiens	56-61
23118901-12	2012	GLT treatment also significantly down-regulated PhIP/DSS-dependent expression of cyclin D1, COX-2, CYP1A2 and CYP3A4 in colon tissue.	dss	53-56	cytochrome c oxidase II, mitochondrial	Mus musculus	92-97
23118901-12	2012	GLT treatment also significantly down-regulated PhIP/DSS-dependent expression of cyclin D1, COX-2, CYP1A2 and CYP3A4 in colon tissue.	dss	53-56	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	99-105
23071715-6	2012	RESULTS: In univariate analyses, high tumor expression of Ki67 (P = 0.007) and Skp2 (P = 0.050) correlated with shorter disease-specific survival (DSS).	dss	147-150	S-phase kinase associated protein 2	Homo sapiens	79-83
23071715-7	2012	In subgroup analysis, a correlation between Skp2 and DSS was seen in patients with malignancy grade 1 or 2 (P = 0.027), tumor size &gt;5 cm (P = 0.018), no radiotherapy given (P = 0.029) and no chemotherapy given (P = 0.017).	dss	53-56	S-phase kinase associated protein 2	Homo sapiens	44-48
23071715-10	2012	In multivariate analyses, Skp2 was an independent negative prognostic factor for DSS in women (P = 0.009) and in patients without administered chemotherapy or radiotherapy (P = 0.026).	dss	81-84	S-phase kinase associated protein 2	Homo sapiens	26-30
22675442-3	2012	METHODOLOGY/PRINCIPAL FINDINGS: Hepcidin expression was evaluated in two types of intestinal inflammation caused by innate immune activation-dextran sulfate sodium (DSS)-induced colitis in wild-type mice and the spontaneous colitis occurring in T-bet/Rag2-deficient (TRUC) mice.	dss	165-168	hepcidin antimicrobial peptide	Mus musculus	32-40
22848392-11	2012	In a comparative analysis we observed the PDZK1 downregulation also in the DSS (dextran sulphate sodium) model of colitis.	dss	75-78	PDZ domain containing 1	Mus musculus	42-47
22675442-6	2012	Hepcidin expression progressively decreased with time during DSS colitis, correlating with changes in systemic iron distribution.	dss	61-64	hepcidin antimicrobial peptide	Mus musculus	0-8
22675442-7	2012	TNFalpha inhibited hepcidin expression in cultured hepatocytes and non-colitic mice, while TNFalpha neutralization during DSS colitis increased it.	dss	122-125	tumor necrosis factor	Mus musculus	91-99
22675454-7	2012	However, when Villin-Klf5 mice were treated with dextran sodium sulfate (DSS) to induce colitis, they developed less colonic injury and significantly reduced disease activity scores than littermate controls.	dss	73-76	Kruppel-like factor 5	Mus musculus	21-25
22675454-8	2012	The mechanism for this decreased injury may come via JAK-STAT signaling, the activation of which was increased in colonic mucosa of DSS treated Villin-Klf5 mice compared to controls.	dss	132-135	Kruppel-like factor 5	Mus musculus	151-155
21815907-13	2012	The secretion of IL-13 was increased in the colon of KO mice after AOM/DSS.	dss	71-74	interleukin 13	Mus musculus	17-22
22454562-7	2012	In univariate analyses, GLUT-1 (P &lt; 0.001) and HIF-2alpha (P = 0.032) expression correlated significantly with a poor disease-specific survival (DSS).	dss	148-151	solute carrier family 2 member 1	Homo sapiens	24-30
22454562-7	2012	In univariate analyses, GLUT-1 (P &lt; 0.001) and HIF-2alpha (P = 0.032) expression correlated significantly with a poor disease-specific survival (DSS).	dss	148-151	endothelial PAS domain protein 1	Homo sapiens	50-60
22454562-8	2012	In the multivariate analysis, however, only high expression of GLUT-1 (HR 1.7, CI 95% 1.1-2.7, P = 0.021) was a significant independent prognostic indicator of poor DSS.	dss	165-168	solute carrier family 2 member 1	Homo sapiens	63-69
21773953-9	2012	Multivariate analysis showed that VEGF expression, vascular invasion, T stage (serosal invasion), and tumor size were significant independent prognostic factors for tumor recurrence, DSS, and OS in patients with pN0 gastric cancer with the exception that T stage was not for DSS.	dss	183-186	vascular endothelial growth factor A	Homo sapiens	34-38
22095225-2	2011	The primary aim of this study was to analyse Y-box-binding protein-1 (YB-1) protein expression in different grading groups of HNSCC patients, and to correlate these findings with the disease-specific survival (DSS).	dss	210-213	Y-box binding protein 1	Homo sapiens	70-74
21773953-7	2012	Univariate analysis showed that VEGF, MMP-9 expression, vascular invasion, T stage, and tumor size were associated with tumor recurrence as well as the disease-specific (DSS) and overall (OS) survival rates.	dss	170-173	vascular endothelial growth factor A	Homo sapiens	32-36
21773953-8	2012	Patients with positive VEGF expression showed significantly higher recurrence and poorer DSS and OS rates compared with those with negative VEGF expression.	dss	89-92	vascular endothelial growth factor A	Homo sapiens	23-27
22095225-3	2011	METHODS: We investigated the expression and cellular localisation of the oncogenic transcription/translation factor YB-1 by immunohistochemistry on tissue micro arrays in a total of 365 HNSCC specimens and correlated expression data with clinico-pathological parameters including DSS.	dss	280-283	Y-box binding protein 1	Homo sapiens	116-120
22095225-5	2011	By univariate survival data analysis, HNSCC patients with elevated YB-1 protein expression had a significantly (P&lt;0.01) decreased DSS.	dss	133-136	Y-box binding protein 1	Homo sapiens	67-71
22095225-6	2011	By multivariate Cox regression analysis, high YB-1 expression and nuclear localisation retained its significance as a statistically independent (P&lt;0.002) prognostic marker for DSS.	dss	179-182	Y-box binding protein 1	Homo sapiens	46-50
22095225-7	2011	Within grade 2 group of HNSCC patients, a subgroup defined by high nuclear and cytoplasmic YB-1 levels (co-expression pattern) in the cells of the tumour invasion front had a significantly poorer 5-year DSS rate of only 38% compared with overall 55% for grade 2 patients.	dss	203-206	Y-box binding protein 1	Homo sapiens	91-95
22095225-8	2011	Vice versa, the DSS rate was markedly increased to 74% for grade 2 cancer patients with low YB-1 protein expression at the same localisation.	dss	16-19	Y-box binding protein 1	Homo sapiens	92-96
22199327-7	2011	However, HIF-1alpha (p=0.024), ezrin (p=0.034), F1 (p=0.011), and F3 (p=0.001) were significant independent predictors of DSS.	dss	122-125	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
22199327-9	2011	However, CAIX (p=0.028), and F1 (p= 0.017) were significantly associated with DSS.	dss	78-81	carbonic anhydrase 9	Homo sapiens	9-13
21636645-9	2011	In response to DSS challenge, Muc13(-/-) mice developed more severe acute colitis, as reflected by increased weight loss, rectal bleeding, diarrhoea and histological colitis scores compared with wild-type mice.	dss	15-18	mucin 13, epithelial transmembrane	Mus musculus	30-35
21636645-11	2011	Muc13(-/-) mice had significantly increased intestinal epithelial cell apoptosis within 3 days of DSS exposure.	dss	98-101	mucin 13, epithelial transmembrane	Mus musculus	0-5
21636645-12	2011	LS513 cells were more susceptible to DSS, actinomycin-D, ultraviolet irradiation and TRAIL-induced apoptosis when MUC13 was knocked down by siRNA.	dss	37-40	mucin 13, cell surface associated	Homo sapiens	114-119
22025164-8	2011	In multivariate analysis adjusted for age, TNM stage, and histologic subtype, the NPC-SVM classifier was an independent predictor of 5-year DSS in the evaluated patients (hazard ratio, 4.9; 95% CI, 3.0 to 7.9) in the validation cohort.	dss	140-143	teneurin transmembrane protein 1	Homo sapiens	43-46
21590770-3	2011	We found that miR-150 was strongly elevated, whereas c-Myb, a transcription factor and a target gene of miR-150, was significantly reduced in colon tissue after DSS treatment.	dss	161-164	microRNA 150	Homo sapiens	14-21
21590770-3	2011	We found that miR-150 was strongly elevated, whereas c-Myb, a transcription factor and a target gene of miR-150, was significantly reduced in colon tissue after DSS treatment.	dss	161-164	MYB proto-oncogene, transcription factor	Homo sapiens	53-58
21590770-3	2011	We found that miR-150 was strongly elevated, whereas c-Myb, a transcription factor and a target gene of miR-150, was significantly reduced in colon tissue after DSS treatment.	dss	161-164	microRNA 150	Homo sapiens	104-111
21590770-5	2011	Supporting the observation of DSS treatment inducing colonic cell apoptosis, Bcl-2, an anti-apoptotic protein known to be regulated by c-Myb, was reduced in colon tissue of DSS-treated mice.	dss	30-33	B cell leukemia/lymphoma 2	Mus musculus	77-82
21590770-5	2011	Supporting the observation of DSS treatment inducing colonic cell apoptosis, Bcl-2, an anti-apoptotic protein known to be regulated by c-Myb, was reduced in colon tissue of DSS-treated mice.	dss	30-33	myeloblastosis oncogene	Mus musculus	135-140
21590770-5	2011	Supporting the observation of DSS treatment inducing colonic cell apoptosis, Bcl-2, an anti-apoptotic protein known to be regulated by c-Myb, was reduced in colon tissue of DSS-treated mice.	dss	173-176	B cell leukemia/lymphoma 2	Mus musculus	77-82
21590770-5	2011	Supporting the observation of DSS treatment inducing colonic cell apoptosis, Bcl-2, an anti-apoptotic protein known to be regulated by c-Myb, was reduced in colon tissue of DSS-treated mice.	dss	173-176	myeloblastosis oncogene	Mus musculus	135-140
21590770-7	2011	Together, the present study presents the first evidence that miR-150 and its targeting of c-Myb may serve as a new mechanism underlying the colonic epithelial disruption in DSS-induced murine experimental colitis and in active human IBD.	dss	173-176	microRNA 150	Mus musculus	61-68
21590770-7	2011	Together, the present study presents the first evidence that miR-150 and its targeting of c-Myb may serve as a new mechanism underlying the colonic epithelial disruption in DSS-induced murine experimental colitis and in active human IBD.	dss	173-176	myeloblastosis oncogene	Mus musculus	90-95
22027740-6	2011	At the univariate level, low LDH-B expression is one of many parameters which significantly predicted both disease-specific survival (DSS) (p = 0.0001) and metastasis-free survival (MeFS) (p = 0.0024).	dss	134-137	lactate dehydrogenase B	Homo sapiens	29-34
22027740-7	2011	In Cox multivariate regression model, higher pT status was the strongest independent prognosticator for both DSS (p = 0.0006) and MeFS (p = 0.0067) while low LDH-B expression remained prognostically significant for DSS (p = 0.0401).	dss	215-218	lactate dehydrogenase B	Homo sapiens	158-163
22023115-11	2011	In multivariate Cox analysis, high securin expression after long-course (chemo)RT was an independent predictor of shorter DSS (p = 0.036) together with patient age (p = 0.043) and disease recurrence (local or distant; p = 0.009), whereas no similar appearance was seen in other treatment groups.	dss	122-125	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	35-42
21924230-7	2011	In contrast, DSS-treated Prnp(-/-) mice exhibited increased BAD protein expression and a cytokine expression profile predicted to favor inflammation and differentiation.	dss	13-16	prion protein	Mus musculus	25-29
21924230-8	2011	PrP(C) expression from both the endogenous Prnp locus or the Tga20 transgene was increased in the colons of DSS-treated mice.	dss	108-111	prion protein	Mus musculus	0-6
21924230-8	2011	PrP(C) expression from both the endogenous Prnp locus or the Tga20 transgene was increased in the colons of DSS-treated mice.	dss	108-111	prion protein	Mus musculus	43-47
21321580-7	2011	Thus we treated WT and gp91(phox-/-) mice with 2.5% DSS for 7 days.	dss	52-55	paired Ig-like receptor B	Mus musculus	23-27
22199291-4	2011	MATERIALS AND METHODS: CD133 was evaluated by immunohistochemistry in a mouse model of colitis-related colon tumorigenesis induced by a combined treatment with azoxymethane (AOM) and dextran sodium sulphate (DSS).	dss	208-211	prominin 1	Mus musculus	23-28
21321580-8	2011	The gp91(phox-/-) mice developed less severe colitis than WT mice following DSS treatment, reflected by a smaller body weight loss, less rectal bleeding and fewer histopathological changes.	dss	76-79	paired Ig-like receptor B	Mus musculus	4-8
21321580-9	2011	Less colonic myeloperoxidase was observed in gp91(phox-/-), compared with WT mice, following DSS challenge, correlating with interleukin (IL)-6 production.	dss	93-96	paired Ig-like receptor B	Mus musculus	45-49
21321580-10	2011	IL-10 was upregulated in both gp91(phox-/-) and WT mice, but was significantly higher in the latter, following 7 days DSS challenge.	dss	118-121	interleukin 10	Mus musculus	0-5
21321580-11	2011	These results suggest that gp91(phox-/-) mice are less susceptible to acute DSS-induced colitis, possibly because of a reduced oxidative burst in the intestine and, consequently, less tissue damage.	dss	76-79	paired Ig-like receptor B	Mus musculus	27-31
21199330-7	2011	The DSS-induced colitis was dramatically more severe in the D DSS(+) group compared with each other group, with no change in superoxide dismutase and glutathione peroxidase activity, but decreased expression of caspase-3 and Bax, and increased Bcl-2 levels.	dss	4-7	caspase 3	Rattus norvegicus	211-220
21987296-4	2011	METHODS: TNF-alpha concentration was measured in plasma, colon, and skeletal muscle of control mice and in mice with dextran sodium sulfate (DSS)-induced colitis.	dss	141-144	tumor necrosis factor	Mus musculus	9-18
21987296-7	2011	DSS-enhanced thrombus formation was evaluated in wildtype (WT) mice treated with an anti-TNF-alpha antibody (+-an anti-IL-1beta antibody) and in TNF-alpha receptor-deficient (TNFr(-/-) ) mice.	dss	0-3	tumor necrosis factor	Mus musculus	89-98
21987296-7	2011	DSS-enhanced thrombus formation was evaluated in wildtype (WT) mice treated with an anti-TNF-alpha antibody (+-an anti-IL-1beta antibody) and in TNF-alpha receptor-deficient (TNFr(-/-) ) mice.	dss	0-3	interleukin 1 beta	Mus musculus	119-127
21987296-7	2011	DSS-enhanced thrombus formation was evaluated in wildtype (WT) mice treated with an anti-TNF-alpha antibody (+-an anti-IL-1beta antibody) and in TNF-alpha receptor-deficient (TNFr(-/-) ) mice.	dss	0-3	tumor necrosis factor	Mus musculus	145-154
21987296-7	2011	DSS-enhanced thrombus formation was evaluated in wildtype (WT) mice treated with an anti-TNF-alpha antibody (+-an anti-IL-1beta antibody) and in TNF-alpha receptor-deficient (TNFr(-/-) ) mice.	dss	0-3	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	175-184
21987296-11	2011	Immunoblockade of TNF-alpha or genetic deficiency of the TNF-alpha receptor blunted the thrombotic response of arterioles to DSS colitis.	dss	125-128	tumor necrosis factor	Mus musculus	18-27
21987296-11	2011	Immunoblockade of TNF-alpha or genetic deficiency of the TNF-alpha receptor blunted the thrombotic response of arterioles to DSS colitis.	dss	125-128	tumor necrosis factor	Mus musculus	57-66
21199330-7	2011	The DSS-induced colitis was dramatically more severe in the D DSS(+) group compared with each other group, with no change in superoxide dismutase and glutathione peroxidase activity, but decreased expression of caspase-3 and Bax, and increased Bcl-2 levels.	dss	4-7	BCL2 associated X, apoptosis regulator	Rattus norvegicus	225-228
21199330-7	2011	The DSS-induced colitis was dramatically more severe in the D DSS(+) group compared with each other group, with no change in superoxide dismutase and glutathione peroxidase activity, but decreased expression of caspase-3 and Bax, and increased Bcl-2 levels.	dss	4-7	BCL2, apoptosis regulator	Rattus norvegicus	244-249
21199330-7	2011	The DSS-induced colitis was dramatically more severe in the D DSS(+) group compared with each other group, with no change in superoxide dismutase and glutathione peroxidase activity, but decreased expression of caspase-3 and Bax, and increased Bcl-2 levels.	dss	62-65	caspase 3	Rattus norvegicus	211-220
21199330-8	2011	The mRNA levels of tumour necrosis factor (TNF)-alpha and protein levels of p38, cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS(+) pups and were accompanied by a decrease in the protein level of tissue inhibitor of metalloproteinases (TIMP)3, a negative regulator of TNF-alpha.	dss	166-169	tumor necrosis factor	Rattus norvegicus	19-53
21199330-8	2011	The mRNA levels of tumour necrosis factor (TNF)-alpha and protein levels of p38, cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS(+) pups and were accompanied by a decrease in the protein level of tissue inhibitor of metalloproteinases (TIMP)3, a negative regulator of TNF-alpha.	dss	166-169	mitogen activated protein kinase 14	Rattus norvegicus	76-79
21199330-8	2011	The mRNA levels of tumour necrosis factor (TNF)-alpha and protein levels of p38, cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS(+) pups and were accompanied by a decrease in the protein level of tissue inhibitor of metalloproteinases (TIMP)3, a negative regulator of TNF-alpha.	dss	166-169	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	81-127
21199330-8	2011	The mRNA levels of tumour necrosis factor (TNF)-alpha and protein levels of p38, cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS(+) pups and were accompanied by a decrease in the protein level of tissue inhibitor of metalloproteinases (TIMP)3, a negative regulator of TNF-alpha.	dss	166-169	TIMP metallopeptidase inhibitor 3	Rattus norvegicus	237-283
21199330-8	2011	The mRNA levels of tumour necrosis factor (TNF)-alpha and protein levels of p38, cytosolic phospolipase A2 and cyclooxygenase 2 were significantly increased in the D DSS(+) pups and were accompanied by a decrease in the protein level of tissue inhibitor of metalloproteinases (TIMP)3, a negative regulator of TNF-alpha.	dss	166-169	tumor necrosis factor	Rattus norvegicus	309-318
21958077-9	2011	These data suggest that in the AOM/DSS model of carcinogenesis, adiponectin functions to promote early lesion development whereas sex and diet are important regulators of advanced lesion development through pathways involved in inflammation and insulin signaling.	dss	35-38	adiponectin, C1Q and collagen domain containing	Mus musculus	64-75
21803737-7	2011	In the mutation assays, DMH plus DSS enhanced the gpt mutant frequency (MF) in the colon, and the silymarin treatments reduced the MFs by 20%.	dss	33-36	glutamic--pyruvic transaminase	Rattus norvegicus	50-53
21992474-12	2011	In multivariate analysis, GP96-overexpression was also an independent predictor of LRC, DSS and OS (p = 0.018, p = 0.011 and p = 0.012).	dss	88-91	heat shock protein 90 beta family member 1	Homo sapiens	26-30
21762661-5	2011	RESULTS: TNBS and DSS induced more severe levels of inflammation in beta-actin-hPepT1 transgenic mice than wild-type littermates.	dss	18-21	actin, beta	Mus musculus	68-78
21762661-5	2011	RESULTS: TNBS and DSS induced more severe levels of inflammation in beta-actin-hPepT1 transgenic mice than wild-type littermates.	dss	18-21	solute carrier family 15 member 1	Homo sapiens	79-85
21712022-4	2011	METHODS: Dextran sodium sulfate (DSS) was used to induce colitis in C57BL/6J-Cftrtm1Unc (Cftr-KO) mice and their wild-type littermates.	dss	33-36	cystic fibrosis transmembrane conductance regulator	Mus musculus	77-81
21762661-6	2011	Intestinal epithelial cell-specific hPepT1 overexpression in villin-hPepT1 transgenic mice increased the severity of inflammation induced by DSS, but not TNBS.	dss	141-144	solute carrier family 15 member 1	Homo sapiens	36-42
21712022-9	2011	RESULTS: DSS-induced colitis caused biliary damage and portal inflammation only in Cftr-KO mice.	dss	9-12	cystic fibrosis transmembrane conductance regulator	Mus musculus	83-87
21762661-8	2011	Antibiotics abolished the effect of hPepT1 overexpression on the inflammatory response in DSS-induced colitis in beta-actin-hPepT1 and villin-hPepT1 transgenic mice, indicating that commensal bacteria are required to aggravate intestinal inflammation.	dss	90-93	solute carrier family 15 member 1	Homo sapiens	36-42
21762661-8	2011	Antibiotics abolished the effect of hPepT1 overexpression on the inflammatory response in DSS-induced colitis in beta-actin-hPepT1 and villin-hPepT1 transgenic mice, indicating that commensal bacteria are required to aggravate intestinal inflammation.	dss	90-93	actin, beta	Mus musculus	113-123
21762661-8	2011	Antibiotics abolished the effect of hPepT1 overexpression on the inflammatory response in DSS-induced colitis in beta-actin-hPepT1 and villin-hPepT1 transgenic mice, indicating that commensal bacteria are required to aggravate intestinal inflammation.	dss	90-93	solute carrier family 15 member 1	Homo sapiens	124-130
21762661-8	2011	Antibiotics abolished the effect of hPepT1 overexpression on the inflammatory response in DSS-induced colitis in beta-actin-hPepT1 and villin-hPepT1 transgenic mice, indicating that commensal bacteria are required to aggravate intestinal inflammation.	dss	90-93	solute carrier family 15 member 1	Homo sapiens	124-130
21762661-10	2011	CONCLUSIONS: The PepT1-NOD2 signaling pathway is involved in aggravation of DSS-induced colitis in mice.	dss	76-79	solute carrier family 15 (oligopeptide transporter), member 1	Mus musculus	17-22
21762661-10	2011	CONCLUSIONS: The PepT1-NOD2 signaling pathway is involved in aggravation of DSS-induced colitis in mice.	dss	76-79	nucleotide-binding oligomerization domain containing 2	Mus musculus	23-27
21870335-0	2011	Increased migration of IgA lymphocytes to VIP nerve fibers after DSS-induced colitis.	dss	65-68	vasoactive intestinal polypeptide	Mus musculus	42-45
21870335-6	2011	In the colon, the number and percentage of IgA(+) lymphocytes close to the basement membrane and the VIP(+) nerve fibers in the lamina propria increased after DSS administration, in parallel with the pathologic progress in the inflamed tissue.	dss	159-162	vasoactive intestinal polypeptide	Mus musculus	101-104
21321579-3	2011	Because several strains of probiotic lactic acid bacteria have been reported to inhibit DSS-induced colitis by unidentified mechanisms, we hypothesized that particular strains of lactic acid bacterium might have the potential to activate the AhR pathway, thereby inhibiting DSS-induced colitis.	dss	274-277	aryl-hydrocarbon receptor	Mus musculus	242-245
21321579-2	2011	Most recently, we have shown that the activation of the AhR pathway by a potent AhR agonist inhibits the development of dextran sodium sulfate (DSS)-induced colitis, a model of human ulcerative colitis, by the induction of prostaglandin E2 (PGE2) in the large intestine.	dss	144-147	aryl hydrocarbon receptor	Homo sapiens	56-59
21321579-2	2011	Most recently, we have shown that the activation of the AhR pathway by a potent AhR agonist inhibits the development of dextran sodium sulfate (DSS)-induced colitis, a model of human ulcerative colitis, by the induction of prostaglandin E2 (PGE2) in the large intestine.	dss	144-147	aryl hydrocarbon receptor	Homo sapiens	80-83
21321579-3	2011	Because several strains of probiotic lactic acid bacteria have been reported to inhibit DSS-induced colitis by unidentified mechanisms, we hypothesized that particular strains of lactic acid bacterium might have the potential to activate the AhR pathway, thereby inhibiting DSS-induced colitis.	dss	88-91	aryl-hydrocarbon receptor	Mus musculus	242-245
21321579-4	2011	This study investigated whether there are specific lactic acid bacterial strains that can activate the AhR pathway, and if so, whether this AhR-activating potential is associated with suppression of DSS-induced colitis.	dss	199-202	aryl-hydrocarbon receptor	Mus musculus	140-143
21898680-5	2011	To this end, we pretreated MSCs with IFN-gamma and assessed their therapeutic effects in dextran sodium sulfate (DSS)- and trinitrobenzene sulfonate (TNBS)-induced colitis in mice.	dss	113-116	interferon gamma	Mus musculus	37-46
22039323-1	2011	AIM: To evaluate whether combination therapy with anti-tumour necrosis factor alpha (TNFalpha) antibody and Zn acetate is beneficial in dextran sodium sulphate (DSS) colitis.	dss	161-164	tumor necrosis factor	Mus musculus	85-93
22039323-6	2011	RESULTS: DSS produced submucosal erosions, ulcers, inflammatory cell infiltration and cryptic abscesses which were reduced in both groups of mice receiving either anti-TNFalpha alone or combined with zinc.	dss	9-12	tumor necrosis factor	Mus musculus	168-176
22039323-8	2011	Myeloperoxidase activity (vs controls, P &lt; 0.02) and DNA adducts, greatly elevated in the DSS fed colitis group (vs controls, P &lt; 0.05), were significantly reduced in the treated groups, with a more remarkable effect in the group receiving combined therapy (vs standard diet, P &lt; 0.04).	dss	93-96	myeloperoxidase	Mus musculus	0-15
22039323-9	2011	CONCLUSION: DSS induces colonic inflammation which is modulated by the administration of anti-TNFalpha.	dss	12-15	tumor necrosis factor	Mus musculus	94-102
21777009-1	2011	The aim of this project is the development of a noninvasive technique based on LED multispectral imaging (MSI) for monitoring the conservation state of the Dead Sea Scrolls (DSS) collection.	dss	174-177	small integral membrane protein 10 like 2A	Homo sapiens	79-82
21374063-4	2011	METHODS AND RESULTS: In in vivo experiments, it was found that dextran sodium sulfate (DSS)-evoked colitis was more severe in AhR KO mice than in C57BL/6J wild type mice.	dss	87-90	aryl hydrocarbon receptor	Homo sapiens	126-129
21597921-9	2011	Triple-negative (Tneg) and HER2-positive (HER2pos) cases DSS events occurred primarily within the first 5 years.	dss	57-60	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-31
21374063-5	2011	It was also revealed that the administration of DSS increased the expression levels of AhR and CYP1A1 mRNA in the colon epithelium.	dss	48-51	aryl hydrocarbon receptor	Homo sapiens	87-90
21374063-5	2011	It was also revealed that the administration of DSS increased the expression levels of AhR and CYP1A1 mRNA in the colon epithelium.	dss	48-51	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	95-101
21374063-6	2011	In addition, oral administration of beta-naphthoflavone (betaNF), a non-toxic agonist of AhR, suppressed the pathogenesis of DSS-induced colitis.	dss	125-128	aryl hydrocarbon receptor	Homo sapiens	89-92
21820333-4	2011	Pharmacological inhibition of NE or treatment with rSLPI reduced DSS-induced mortality in Tslp(-/-) mice.	dss	65-68	elastase, neutrophil expressed	Mus musculus	30-32
22072824-0	2011	Parasitic helminth cystatin inhibits DSS-induced intestinal inflammation via IL-10(+)F4/80(+) macrophage recruitment.	dss	37-40	interleukin 10	Mus musculus	77-82
22072824-7	2011	The secretion levels of IFN-gamma and TNF-alpha in the spleen and mesenteric lymph nodes (MLNs) were significantly increased by DSS treatment, but the level of TNF-alpha in MLNs was significantly decreased by rCsStefin-1 treatment.	dss	128-131	interferon gamma	Mus musculus	24-33
22072824-7	2011	The secretion levels of IFN-gamma and TNF-alpha in the spleen and mesenteric lymph nodes (MLNs) were significantly increased by DSS treatment, but the level of TNF-alpha in MLNs was significantly decreased by rCsStefin-1 treatment.	dss	128-131	tumor necrosis factor	Mus musculus	38-47
22866128-6	2011	In conclusion, the present study showed that PSK not only suppressed colorectal tumor formation in the DMH+DSS-induced IBD model, but also improved the survival rate, indicating that anti-inflammatory activity is one of the mechanisms for the antitumor effects of PSK.	dss	107-110	TAO kinase 2	Mus musculus	45-48
21820333-4	2011	Pharmacological inhibition of NE or treatment with rSLPI reduced DSS-induced mortality in Tslp(-/-) mice.	dss	65-68	thymic stromal lymphopoietin	Mus musculus	90-94
21820333-5	2011	Signaling through TSLPR on nonhematopoietic cells was sufficient for recovery from DSS-induced colitis.	dss	83-86	cytokine receptor-like factor 2	Mus musculus	18-23
21806815-5	2011	RESULTS: In both acute and chronic DSS-induced colitis, compared to wild-type mice, ILK-ko mice exhibit less weight loss, and have reduced inflammatory scores.	dss	35-38	integrin linked kinase	Mus musculus	84-87
21652768-6	2011	Junctional zone prolactin family 5, subfamily a, member 1 (Prl5a1) transcript levels were significantly greater in BN rats than in HSD or DSS rats.	dss	138-141	prolactin family 5, subfamily A, member 1	Rattus norvegicus	16-57
21652768-6	2011	Junctional zone prolactin family 5, subfamily a, member 1 (Prl5a1) transcript levels were significantly greater in BN rats than in HSD or DSS rats.	dss	138-141	prolactin family 5, subfamily A, member 1	Rattus norvegicus	59-65
21652768-7	2011	Prl5a1 transcript levels were used as a quantitative trait to screen placentation sites from chromosome-substituted rat strains (BN chromosomes introgressed into the DSS inbred strain; DSS-BN panel).	dss	166-169	prolactin family 5, subfamily A, member 1	Rattus norvegicus	0-6
21652768-7	2011	Prl5a1 transcript levels were used as a quantitative trait to screen placentation sites from chromosome-substituted rat strains (BN chromosomes introgressed into the DSS inbred strain; DSS-BN panel).	dss	185-188	prolactin family 5, subfamily A, member 1	Rattus norvegicus	0-6
21652768-10	2011	Chromosome-substituted strains possessing BN chromosomes 14 or 17 introgressed into the DSS inbred rat strain displayed Prl5a1 transcript levels that were significantly different from the DSS pattern and more closely resembled the BN pattern.	dss	88-91	prolactin family 5, subfamily A, member 1	Rattus norvegicus	120-126
21636244-17	2011	Ulceration and SLN status proved to be the strongest prognostic factors for long-term DFS and DSS.	dss	94-97	sarcolipin	Homo sapiens	15-18
21801866-5	2011	We found that MOR activation attenuated DSS-induced histologic and gross intestinal injury and weight loss; diminished Ifng, Tnf, and Il6 mRNA expression; and promoted intestinal healing during recovery.	dss	40-43	opioid receptor, mu 1	Mus musculus	14-17
21801866-5	2011	We found that MOR activation attenuated DSS-induced histologic and gross intestinal injury and weight loss; diminished Ifng, Tnf, and Il6 mRNA expression; and promoted intestinal healing during recovery.	dss	40-43	tumor necrosis factor	Mus musculus	125-128
21801866-9	2011	Together, this work shows that MOR activation protects against and enhances recovery from DSS-induced intestinal injury.	dss	90-93	opioid receptor, mu 1	Mus musculus	31-34
21442372-7	2011	We also determined the effect of wortmannin on tumor necrosis factor-alpha (TNF-alpha) expression in intestinal biopsy tissues of UC patients and mice with DSS-induced colitis.	dss	156-159	tumor necrosis factor	Homo sapiens	76-85
21636244-16	2011	The long-term follow-up data confirm that tumor-positive SLN patients have a worse DFS and DSS than tumor-negative SLN patients.	dss	91-94	sarcolipin	Homo sapiens	57-60
21367960-5	2011	Occurrence of colonic mucosal ulcer and dysplastic crypt induced by AOM/DSS treatment was also significantly decreased by the administration of diosgenin and sanyaku, which was in accordance with the significant reduction of AOM/DSS-mediated increases in expression of inflammatory cytokines such as IL-1beta by diosgenin and sanyaku.	dss	72-75	interleukin 1 beta	Mus musculus	300-308
21744423-7	2011	After withdrawal of DSS, Prkci KO mice exhibited a continued increase in apoptosis, inflammation, and damage to the intestinal microvasculature and a progressive loss of trefoil factor 3 (TFF3) expression, a regulatory peptide important for intestinal wound healing.	dss	20-23	protein kinase C, iota	Mus musculus	25-30
21744423-9	2011	CONCLUSIONS: Expression of PKCiota in the intestinal epithelium protects against DSS-induced colitis.	dss	81-84	protein kinase C, iota	Mus musculus	27-34
21744423-10	2011	Our data suggest that PKCiota reduces DSS-induced damage by promoting intestinal epithelial wound healing through the control of TFF3 expression.	dss	38-41	protein kinase C, iota	Mus musculus	22-29
21744423-10	2011	Our data suggest that PKCiota reduces DSS-induced damage by promoting intestinal epithelial wound healing through the control of TFF3 expression.	dss	38-41	trefoil factor 3, intestinal	Mus musculus	129-133
21744424-5	2011	Colitis was induced with dextran sodium sulfate (DSS) in A3-/-AR or wildtype (WT) age- and sex-matched controls.	dss	49-52	adenosine A3 receptor	Mus musculus	57-64
21744424-11	2011	DSS downregulated A3AR in epithelia.	dss	0-3	adenosine A3 receptor	Mus musculus	18-22
21744424-13	2011	A3-/-AR phenotype protected against DSS-induced weight loss, neutrophil (MPO), or CD4(+) -T cell infiltration, colon shortening, change in splenic weight, diarrhea, or occult-fecal blood.	dss	36-39	adenosine A3 receptor	Mus musculus	0-7
21744424-17	2011	In separate studies, A3-/-AR protects against DSS colitis, consistent with a novel hypothesis that A3AR activation contributes to development of colitis.	dss	46-49	adenosine A3 receptor	Mus musculus	21-28
21602714-5	2011	RESULTS: The gene encoding alpha-kinase 2 (Alpk2) contains a three base-pair deletion and multiple nonconserved mutations in its coding region in Dahl salt-sensitive (DSS) rats.	dss	167-170	alpha-kinase 2	Rattus norvegicus	27-41
21602714-5	2011	RESULTS: The gene encoding alpha-kinase 2 (Alpk2) contains a three base-pair deletion and multiple nonconserved mutations in its coding region in Dahl salt-sensitive (DSS) rats.	dss	167-170	alpha-kinase 2	Rattus norvegicus	43-48
21602714-6	2011	In contrast, the gastrin-releasing peptide gene (Grp) possesses two nonconserved mutations, designated as single nucleotide polymorphisms 1 and 2 (i.e. SNP1 and SNP2), but could not be supported as a candidate gene because the C18S.L14 congenic strain displayed a homozygous DSS genotype at both SNP1 and SNP2.	dss	275-278	gastrin releasing peptide	Rattus norvegicus	17-42
21602714-6	2011	In contrast, the gastrin-releasing peptide gene (Grp) possesses two nonconserved mutations, designated as single nucleotide polymorphisms 1 and 2 (i.e. SNP1 and SNP2), but could not be supported as a candidate gene because the C18S.L14 congenic strain displayed a homozygous DSS genotype at both SNP1 and SNP2.	dss	275-278	gastrin releasing peptide	Rattus norvegicus	49-52
21537329-11	2011	Re-epithelialization was absent in CXCR4 conditional knockout mice following acute DSS-induced inflammation.	dss	83-86	chemokine (C-X-C motif) receptor 4	Mus musculus	35-40
21413942-5	2011	Splenic Gr1(+)CD11b(+) cell number was greatly increased during the recovery phase of DSS-induced colitis.	dss	86-89	integrin subunit alpha M	Homo sapiens	14-19
21413942-6	2011	DSS-derived splenic Gr1(+)CD11b(+) cells were administered intravenously to recipient (C57BL/6) mice during the early phase of DSS treatment.	dss	0-3	integrin subunit alpha M	Homo sapiens	26-31
21413942-7	2011	The transplanted splenic DSS-induced Gr1(+)CD11b(+) cells improved DSS-induced colitis and promoted efficient colonic mucosal healing.	dss	25-28	integrin subunit alpha M	Homo sapiens	43-48
21413942-7	2011	The transplanted splenic DSS-induced Gr1(+)CD11b(+) cells improved DSS-induced colitis and promoted efficient colonic mucosal healing.	dss	67-70	integrin subunit alpha M	Homo sapiens	43-48
21413942-8	2011	We found that the CD11b(+) single positive cells increased in the course of DSS-induced colitis in lamina propria.	dss	76-79	integrin subunit alpha M	Homo sapiens	18-23
21413942-11	2011	Further, transplantation of Gr-1(+)CD11b(+) cells greatly suppressed the increase of the same population, especially during the late phase of DSS colitis both in spleen and bone marrow.	dss	142-145	integrin subunit alpha M	Homo sapiens	35-40
21484853-4	2011	We introduce a table of DSs for the developing chick optic tectum (OT) based on time- and space-dependent changes in quantitative morphometric parameters, qualitative histogenetic features and immunocytochemical pattern of several developmentally active molecules (Notch1, Hes5, NeuroD1, beta-III-Tubulin, synaptotagmin-I and neurofilament-M).	dss	24-27	notch 1	Gallus gallus	265-271
21484853-4	2011	We introduce a table of DSs for the developing chick optic tectum (OT) based on time- and space-dependent changes in quantitative morphometric parameters, qualitative histogenetic features and immunocytochemical pattern of several developmentally active molecules (Notch1, Hes5, NeuroD1, beta-III-Tubulin, synaptotagmin-I and neurofilament-M).	dss	24-27	hes family bHLH transcription factor 5	Gallus gallus	273-277
21484853-4	2011	We introduce a table of DSs for the developing chick optic tectum (OT) based on time- and space-dependent changes in quantitative morphometric parameters, qualitative histogenetic features and immunocytochemical pattern of several developmentally active molecules (Notch1, Hes5, NeuroD1, beta-III-Tubulin, synaptotagmin-I and neurofilament-M).	dss	24-27	neuronal differentiation 1	Gallus gallus	279-286
21484853-4	2011	We introduce a table of DSs for the developing chick optic tectum (OT) based on time- and space-dependent changes in quantitative morphometric parameters, qualitative histogenetic features and immunocytochemical pattern of several developmentally active molecules (Notch1, Hes5, NeuroD1, beta-III-Tubulin, synaptotagmin-I and neurofilament-M).	dss	24-27	synaptotagmin 1	Gallus gallus	306-321
21432853-5	2011	After DSS treatment, PSGL-1(-/-) mice developed colitis earlier and with higher severity than wild-type (WT) mice.	dss	6-9	selectin, platelet (p-selectin) ligand	Mus musculus	21-27
21432853-7	2011	Together, our data indicate that PSGL-1 has a relevant homeostatic role in the gut-associated lymphoid tissue under steady-state conditions, and that this adhesion receptor is able to down-regulate the inflammatory phenomenon in DSS-induced colitis.	dss	229-232	selectin, platelet (p-selectin) ligand	Mus musculus	33-39
21893696-5	2011	The aim of the present study was to assess the effects of nuclear PPAR-gamma activity on the course of experimental acute colitis induced by intragastric administration of dextran sodium sulphate (DSS) using the PPAR-gamma agonist rosiglitazone and the antagonist BADGE in rats.	dss	197-200	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	66-76
21555532-3	2011	In this article, we show that dextran sodium sulfate (DSS)-induced clinical disease and histological damage to the colonic mucosa were significantly less severe in GC-C(-/-) mice and moderately reduced in Gn(-/-) animals.	dss	54-57	guanylate cyclase 2c	Mus musculus	164-168
21555532-4	2011	Relative to wild-type controls, GC-C(-/-) and Gn(-/-) mice had reduced apoptosis and increased proliferation of intestinal epithelial cells during DSS colitis.	dss	147-150	guanylate cyclase 2c	Mus musculus	32-36
21555532-5	2011	Basal and DSS-induced production of resistin-like molecule beta (RELMbeta) was substantially diminished in GC-C(-/-) mice.	dss	10-13	resistin like beta	Mus musculus	36-63
21555532-5	2011	Basal and DSS-induced production of resistin-like molecule beta (RELMbeta) was substantially diminished in GC-C(-/-) mice.	dss	10-13	resistin like beta	Mus musculus	65-73
21555532-5	2011	Basal and DSS-induced production of resistin-like molecule beta (RELMbeta) was substantially diminished in GC-C(-/-) mice.	dss	10-13	guanylate cyclase 2c	Mus musculus	107-111
21555532-8	2011	Colonic instillation of recombinant RELMbeta by enema into GC-C(-/-) mice restores sensitivity to DSS-mediated mucosal injury.	dss	98-101	resistin like beta	Mus musculus	36-44
21555532-8	2011	Colonic instillation of recombinant RELMbeta by enema into GC-C(-/-) mice restores sensitivity to DSS-mediated mucosal injury.	dss	98-101	guanylate cyclase 2c	Mus musculus	59-63
21431278-2	2011	The aim of this study was to investigate whether a DPP-IV inhibitor can promote epithelial proliferation and attenuate dextran sodium sulfate (DSS)-induced colitis.	dss	143-146	dipeptidylpeptidase 4	Mus musculus	51-57
21565393-3	2011	NLRP6 inflammasome-deficient mice were characterized by spontaneous intestinal hyperplasia, inflammatory cell recruitment, and exacerbation of chemical colitis induced by exposure to dextran sodium sulfate (DSS).	dss	207-210	NLR family, pyrin domain containing 6	Mus musculus	0-5
21498668-4	2011	We show that dextran sodium sulfate (DSS) treatment promotes the recruitment of F4/80(+)CD11b(+)CCR2(+)Ly6C(high) inflammatory monocytes into the colon.	dss	37-40	integrin alpha M	Mus musculus	80-93
21075472-5	2011	Among adenocarcinoma patients high tumor expression of GLUT1 and low stromal expression of LDH5 correlated significantly with a poor DSS in both univariate (GLUT1, P=0.01; LDH5, P=0.03) and multivariate analyses (GLUT1, HR=1.9, P=0.046; LDH5, HR=2.3, P=0.03).	dss	133-136	solute carrier family 2 member 1	Homo sapiens	55-60
21498668-4	2011	We show that dextran sodium sulfate (DSS) treatment promotes the recruitment of F4/80(+)CD11b(+)CCR2(+)Ly6C(high) inflammatory monocytes into the colon.	dss	37-40	chemokine (C-C motif) receptor 2	Mus musculus	96-100
21498668-4	2011	We show that dextran sodium sulfate (DSS) treatment promotes the recruitment of F4/80(+)CD11b(+)CCR2(+)Ly6C(high) inflammatory monocytes into the colon.	dss	37-40	lymphocyte antigen 6 complex, locus C1	Mus musculus	103-107
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	15-18	integrin alpha M	Mus musculus	35-40
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	15-18	chemokine (C-C motif) receptor 2	Mus musculus	43-47
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	15-18	lymphocyte antigen 6 complex, locus C1	Mus musculus	50-54
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	15-18	chemokine (C-C motif) receptor 2	Mus musculus	98-102
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	15-18	chemokine (C-C motif) ligand 11	Mus musculus	151-156
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	200-203	integrin alpha M	Mus musculus	35-40
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	200-203	lymphocyte antigen 6 complex, locus C1	Mus musculus	50-54
21498668-7	2011	Attenuation of DSS-induced F4/80(+)CD11b(+)CCR2(+)Ly6C(high) monocyte recruitment to the colon in CCR2(-/-) mice was associated with decreased colonic CCL11 expression, eosinophilic inflammation, and DSS-induced histopathology.	dss	200-203	chemokine (C-C motif) receptor 2	Mus musculus	98-102
21498668-8	2011	These studies identify a mechanism for DSS-induced colonic eosinophilia mediated by Ly6C(high)CCR2(+) inflammatory monocyte/macrophage-derived CCL11.	dss	39-42	lymphocyte antigen 6 complex, locus C1	Mus musculus	84-88
21498668-8	2011	These studies identify a mechanism for DSS-induced colonic eosinophilia mediated by Ly6C(high)CCR2(+) inflammatory monocyte/macrophage-derived CCL11.	dss	39-42	chemokine (C-C motif) receptor 2	Mus musculus	94-98
21498668-8	2011	These studies identify a mechanism for DSS-induced colonic eosinophilia mediated by Ly6C(high)CCR2(+) inflammatory monocyte/macrophage-derived CCL11.	dss	39-42	chemokine (C-C motif) ligand 11	Mus musculus	143-148
21322651-11	2011	By this comprehensive study, we identified 14-3-3 zeta as the only prognosticator of local recurrence-free survival (LRFS) and also an independently predicted factor of disease-specific survival (DSS).	dss	196-199	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	43-54
21505452-9	2011	In univariate analysis, age, stage, histology type and CD151 were significant for both recurrence free (RFS) and disease specific survival (DSS).	dss	140-143	CD151 molecule (Raph blood group)	Homo sapiens	55-60
21505452-10	2011	In multivariate analyses, CD151 was significant for RFS and DSS (P=0.036 and 0.033, respectively) in triple negative (ER, PR and HER-2 negative) tumours (88/131).	dss	60-63	CD151 molecule (Raph blood group)	Homo sapiens	26-31
20981572-8	2011	RESULTS: The mRNA expression levels of CSE and CBS, and the H(2)S content in the colonic mucosa were increased with time after DSS administration.	dss	127-130	cystathionase (cystathionine gamma-lyase)	Mus musculus	39-42
20981572-8	2011	RESULTS: The mRNA expression levels of CSE and CBS, and the H(2)S content in the colonic mucosa were increased with time after DSS administration.	dss	127-130	cystathionine beta-synthase	Mus musculus	47-50
20872832-10	2011	Here we show that therapeutic delivery of PHB to the colon reduces the severity of DSS-induced colitis in mice.	dss	83-86	prohibitin	Mus musculus	42-45
21490394-8	2011	Furthermore, treating mice with infliximab (Remicade), a clinically used TNF-specific antibody, suppressed DSS- and TNBS-induced PUMA expression and colitis.	dss	107-110	tumor necrosis factor	Mus musculus	73-76
21310817-2	2011	This study explored the effects of the immunomodulator glatiramer acetate (GA; Copaxone) treatment on syndecan-1 expression in dextran sodium sulfate (DSS)-induced colitis.	dss	151-154	syndecan 1	Mus musculus	102-112
21068720-5	2011	Moreover, macrophage PPAR-gamma was required for accelerating pioglitazone-mediated recovery from dextran sodium sulfate (DSS) colitis, providing a cellular target for the anti-inflammatory effects of PPAR-gamma agonists in IBD.	dss	122-125	peroxisome proliferator activated receptor gamma	Mus musculus	21-31
21068720-5	2011	Moreover, macrophage PPAR-gamma was required for accelerating pioglitazone-mediated recovery from dextran sodium sulfate (DSS) colitis, providing a cellular target for the anti-inflammatory effects of PPAR-gamma agonists in IBD.	dss	122-125	peroxisome proliferator activated receptor gamma	Mus musculus	201-211
21204854-7	2011	In conclusion, rAs-MIF appears to ameliorate DSS-induced colitis and may prove useful as a therapeutic agent for the treatment of intestinal inflammatory disease.	dss	45-48	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	19-22
21316381-10	2011	Organ culture with WSS or DSS (25ng nicotine/ml) lowered the 5-HT(1B) receptor-mediated contraction.	dss	26-29	5-hydroxytryptamine receptor 1B	Rattus norvegicus	61-68
21316381-14	2011	Only the DSS group showed that the increase of 5-HT(1B) receptor-mediated contraction occurred at the transcriptional level, demonstrated by an increased mRNA expression for the receptor.	dss	9-12	5-hydroxytryptamine receptor 1B	Rattus norvegicus	47-54
21360437-5	2011	In endothelial cells snail1 expression was observed in 51 (48%) of 107 cases and it predicted reduced disease specific survival (DSS) (p=0.009).	dss	129-132	snail family transcriptional repressor 1	Homo sapiens	21-27
21438905-3	2011	Cyclin D1 was correlated with various tumour features and biochemical recurrence-free survival (bRFS), disease-specific survival (DSS) and overall survival (OS).	dss	130-133	cyclin D1	Homo sapiens	0-9
21438905-4	2011	In the metastases, high-level cytoplasmic cyclin D1 expression independently predicted poor outcome (5-year bRFS, 12.5% versus 26.4%, P = 0.006; 5-year DSS, 56.3% versus 80.7%, P = 0.007; 5-year OS, 56.3% versus 78.7%, P = 0.011).	dss	152-155	cyclin D1	Homo sapiens	42-51
21391286-7	2011	Analysis of 16S rRNA-encoding gene clone libraries demonstrated that the microbial communities in the ceca of DSS-treated mice were distinct from those in control mice.	dss	110-113	DNA segment, 16S	Mus musculus	12-15
21271213-10	2011	In the multivariate analysis, the ER-/PgR+ phenotype was an independent negative prognostic factor for DSS (HR=1.9, 95% CI=1.2-3.1, P=0.008) in addition to patient"s nationality, tumor depth, histological entity, malignancy grade, metastasis at diagnosis, surgery and positive resection margins.	dss	103-106	progesterone receptor	Homo sapiens	38-41
21271213-11	2011	The present findings indicate that ER and PgR have significant gender dependent impact on DSS in non-GIST STSs.	dss	90-93	progesterone receptor	Homo sapiens	42-45
21624200-3	2011	Mice genetically deficient in A20 develop severe intestinal inflammation and have increased susceptibility to dextran sodium sulfate (DSS)-induced colitis.	dss	134-137	tumor necrosis factor, alpha-induced protein 3	Mus musculus	30-33
21390241-7	2011	In the multivariate analysis, high TGF-beta1 expression was an independent negative prognostic factor for DSS (HR = 1.6, 95% CI = 1.1-2.4, P = 0.019) in addition to tumor depth, malignancy grade, metastasis at diagnosis, surgery and positive resection margins.	dss	106-109	transforming growth factor beta 1	Homo sapiens	35-44
21390241-8	2011	CONCLUSION: Expression of TGF-beta1 was significantly associated with aggressive behavior and shorter DSS in non-GIST STSs.	dss	102-105	transforming growth factor beta 1	Homo sapiens	26-35
21164491-4	2011	RESULTS: DSS/H rats exhibited hypertension, leakage from brain microvessels in the hippocampus, and impaired cognitive functions, which were associated with increased brain AngII levels, as well as decreased mRNA levels of tight junctions (TJs) and collagen-IV in the hippocampus.	dss	9-12	angiotensinogen	Rattus norvegicus	173-178
21310817-10	2011	We concluded that syndecan-1 expression is reduced in DSS-induced colitis and could be a potential prognostic factor in IBD.	dss	54-57	syndecan 1	Mus musculus	18-28
22977493-7	2011	The expression of p-STAT3 and EGFR was significantly related to distant metastasis and recurrence (p=0.001 and p=0.039), as well as significantly poorer disease-specific survival (DSS; p=0.0018 and p=0.026).	dss	180-183	signal transducer and activator of transcription 3	Homo sapiens	20-25
22977493-7	2011	The expression of p-STAT3 and EGFR was significantly related to distant metastasis and recurrence (p=0.001 and p=0.039), as well as significantly poorer disease-specific survival (DSS; p=0.0018 and p=0.026).	dss	180-183	epidermal growth factor receptor	Homo sapiens	30-34
22977493-8	2011	The expression of p-STAT3 was a marginally non-significant prognostic factor for DSS (hazard ratio=2.0, 95% CI 0.91-4.5, p=0.082).	dss	81-84	signal transducer and activator of transcription 3	Homo sapiens	20-25
22977493-9	2011	Increasing expression of p-STAT3, p-mTOR and EGFR was associated with progressively worse DSS.	dss	90-93	signal transducer and activator of transcription 3	Homo sapiens	27-32
22977493-9	2011	Increasing expression of p-STAT3, p-mTOR and EGFR was associated with progressively worse DSS.	dss	90-93	mechanistic target of rapamycin kinase	Homo sapiens	36-40
22977493-9	2011	Increasing expression of p-STAT3, p-mTOR and EGFR was associated with progressively worse DSS.	dss	90-93	epidermal growth factor receptor	Homo sapiens	45-49
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	144-147	tachykinin precursor 3	Rattus norvegicus	27-39
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	144-147	tachykinin precursor 3	Rattus norvegicus	41-45
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	144-147	neurexophilin 4	Rattus norvegicus	48-63
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	144-147	neurexophilin 4	Rattus norvegicus	65-70
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	144-147	retinol dehydrogenase 16	Rattus norvegicus	76-99
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	144-147	retinol dehydrogenase 16	Rattus norvegicus	101-105
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	191-194	tachykinin precursor 3	Rattus norvegicus	27-39
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	191-194	tachykinin precursor 3	Rattus norvegicus	41-45
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	191-194	neurexophilin 4	Rattus norvegicus	48-63
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	191-194	neurexophilin 4	Rattus norvegicus	65-70
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	191-194	retinol dehydrogenase 16	Rattus norvegicus	76-99
21192272-8	2011	Among the candidate genes, tachykinin 2 (Tac2), neurexophilin 4 (Nxph4) and retinol dehydrogenase 2 (Rdh2) bear nonsynonymous changes comparing DSS and Lewis rats, but are the same comparing DSS and Dahl salt-resistant (DSR) rats.	dss	191-194	retinol dehydrogenase 16	Rattus norvegicus	101-105
21192272-9	2011	In contrast, the Lewis alleles of 11-beta-hydroxylase (Cyp11b1), aldosterone synthase (Cyp11b2) and Cytochrome P-450 11B3 (Cyp11b3) are identical to those of DSS rats, but different from those of DSR rats.	dss	158-161	cytochrome P450, family 11, subfamily b, polypeptide 1	Rattus norvegicus	55-62
21192272-9	2011	In contrast, the Lewis alleles of 11-beta-hydroxylase (Cyp11b1), aldosterone synthase (Cyp11b2) and Cytochrome P-450 11B3 (Cyp11b3) are identical to those of DSS rats, but different from those of DSR rats.	dss	158-161	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	65-85
21192272-9	2011	In contrast, the Lewis alleles of 11-beta-hydroxylase (Cyp11b1), aldosterone synthase (Cyp11b2) and Cytochrome P-450 11B3 (Cyp11b3) are identical to those of DSS rats, but different from those of DSR rats.	dss	158-161	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	87-94
21192272-9	2011	In contrast, the Lewis alleles of 11-beta-hydroxylase (Cyp11b1), aldosterone synthase (Cyp11b2) and Cytochrome P-450 11B3 (Cyp11b3) are identical to those of DSS rats, but different from those of DSR rats.	dss	158-161	cytochrome P450, family 11, subfamily b, polypeptide 3	Rattus norvegicus	123-130
21166993-2	2011	OBJECTIVES: The objective of this study was to assess the contribution of the CD40/CD40L signaling system to the enhanced microvascular thrombosis that accompanies two distinct experimental models of inflammation, that is, endotoxemia (lipopolysaccharide [LPS]) and dextran sodium sulfate (DSS)-induced colitis.	dss	290-293	CD40 antigen	Mus musculus	78-82
19556153-12	2011	These findings suggest that abilities of TNM pN status and LND in node-positive patients to predict DSS could be affected by the total number of lymph nodes removed.	dss	100-103	teneurin transmembrane protein 1	Homo sapiens	41-44
21303973-0	2011	MTGR1 is required for tumorigenesis in the murine AOM/DSS colitis-associated carcinoma model.	dss	54-57	CBFA2/RUNX1 translocation partner 2	Mus musculus	0-5
21303973-6	2011	We report that Mtgr1(-/-) mice were protected from tumorigenesis when injected with azoxymethane (AOM) and then subjected to repeated cycles of dextran sodium sulfate (DSS).	dss	168-171	CBFA2/RUNX1 translocation partner 2	Mus musculus	15-20
20680693-6	2011	RESULTS: Kaplan-Meier analysis of survival revealed that no single alteration of the factors examined was associated with outcome, but tumors showing concomitant alteration of p16 and p53 were characterized by reduced MDFS and DSS (P = 0.01 and P &lt; 0.001, respectively).	dss	227-230	cyclin dependent kinase inhibitor 2A	Homo sapiens	176-179
21109593-9	2011	Muc2(-/-) mice, which lacked firmly adherent mucus, were predisposed to colitis, whereas Muc1(-/-) mice were protected with significantly lower DAI by DSS compared with wt mice.	dss	151-154	mucin 1, transmembrane	Mus musculus	89-93
21109593-10	2011	The mucus barrier increased in Muc1(-/-) mice in response to DSS, whereas significantly fewer T cells were recruited to the inflamed colon.	dss	61-64	mucin 1, transmembrane	Mus musculus	31-35
21109593-13	2011	Mice lacking colonic mucus (Muc2(-/-)) were hypersensitive to DSS-induced colitis, whereas Muc1(-/-) were protected, probably through the ability to increase the mucus barrier but also by decreased T cell recruitment to the afflicted site.	dss	62-65	mucin 2	Mus musculus	28-32
20680693-6	2011	RESULTS: Kaplan-Meier analysis of survival revealed that no single alteration of the factors examined was associated with outcome, but tumors showing concomitant alteration of p16 and p53 were characterized by reduced MDFS and DSS (P = 0.01 and P &lt; 0.001, respectively).	dss	227-230	tumor protein p53	Homo sapiens	184-187
20680693-8	2011	In multivariate analysis, altered p16/p53 remained the only parameter predictive of MDFS and DSS (P = 0.048, hazard ratio [HR] = 2.488, 95% confidence interval [95% CI] 1.006-5.116; P = 0.043, HR = 2.498, 95% CI 1.029-5.909, respectively).	dss	93-96	cyclin dependent kinase inhibitor 2A	Homo sapiens	34-37
20680693-8	2011	In multivariate analysis, altered p16/p53 remained the only parameter predictive of MDFS and DSS (P = 0.048, hazard ratio [HR] = 2.488, 95% confidence interval [95% CI] 1.006-5.116; P = 0.043, HR = 2.498, 95% CI 1.029-5.909, respectively).	dss	93-96	tumor protein p53	Homo sapiens	38-41
21081470-10	2011	These results illustrate that PhIP and DSS combination produces rapid colon carcinogenesis in hCYP1A-mice and this is an effective model to mimic human colon carcinogenesis.	dss	39-42	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	94-99
21087444-3	2011	The membranous fraction of P. distasonis (mPd) prevented DSS-induced increases in several proinflammatory cytokines, increased mPd-specific serum antibodies and stabilized the intestinal microbial ecology.	dss	57-60	mevalonate (diphospho) decarboxylase	Mus musculus	42-45
21298041-6	2011	RESULTS: In univariate analyses, increased numbers of CD4+ (P = 0.008) and CD20+ (P = 0.006) lymphocytes in tumor correlated significantly with an improved disease-specific survival (DSS) in patients with wide resection margins (n = 108).	dss	183-186	keratin 20	Homo sapiens	75-79
21298041-8	2011	In multivariate analyses, a high number of CD20+ lymphocytes (HR = 5.5, CI 95%  = 1.6-18.6, P = 0.006) in the tumor was an independent positive prognostic factor for DSS in patients with wide resections margins.	dss	166-169	keratin 20	Homo sapiens	43-47
21224053-3	2011	TLR2-deficient mice (TLR2(-/-)) developed a more severe colitis than wild-type mice in the dextran sodium sulfate (DSS) model.	dss	115-118	toll-like receptor 2	Mus musculus	0-4
21173247-6	2011	The mMCP-6-null mice that had been exposed to DSS had significantly less weight loss as well as significantly lower pathology and endoscopy scores than similarly treated mMCP-6-expressing mice.	dss	46-49	tryptase beta 2	Mus musculus	4-10
21039426-8	2011	Mouse beta-defensin 3 (mBD-3, orthologue to hBD-2) was up-regulated strongly in colonic epithelium of 15-week-old IL-2(-/-) mice and DSS-induced colitis mice with chronic bowel inflammation, but not in apparently healthy IL-2(-/-) 5-week-old mice, IL-2(+/-) 15-week-old mice or in acute stage DSS mice.	dss	133-136	defensin beta 3	Mus musculus	6-21
21295288-1	2011	Distinct roles of the two T cell G protein-coupled receptors for vasoactive intestinal peptide (VIP), termed VPAC1 and VPAC2, in VIP regulation of autoimmune diseases were investigated in the dextran sodium sulfate (DSS)-induced murine acute colitis model for human inflammatory bowel diseases.	dss	216-219	vasoactive intestinal polypeptide	Mus musculus	96-99
21295288-2	2011	In mice lacking VPAC2 (VPAC2-KO), DSS-induced colitis appeared more rapidly with greater weight loss and severe histopathology than in wild-type mice.	dss	34-37	vasoactive intestinal peptide receptor 2	Mus musculus	16-21
21295288-2	2011	In mice lacking VPAC2 (VPAC2-KO), DSS-induced colitis appeared more rapidly with greater weight loss and severe histopathology than in wild-type mice.	dss	34-37	vasoactive intestinal peptide receptor 2	Mus musculus	23-31
21295288-3	2011	In contrast, DSS-induced colitis in VPAC1-KO mice was milder than in wild-type mice and VPAC2-KO mice.	dss	13-16	vasoactive intestinal peptide receptor 1	Mus musculus	36-41
21295288-3	2011	In contrast, DSS-induced colitis in VPAC1-KO mice was milder than in wild-type mice and VPAC2-KO mice.	dss	13-16	vasoactive intestinal peptide receptor 2	Mus musculus	88-96
21295288-5	2011	Suppression of VPAC1 signals in VPAC2-KO mice by PKA inhibitors reduced the clinical and histological severity of DSS-induced colitis, as well as tissue levels of IL-6, IL-1beta and MMP-9.	dss	114-117	vasoactive intestinal peptide receptor 1	Mus musculus	15-20
21295288-5	2011	Suppression of VPAC1 signals in VPAC2-KO mice by PKA inhibitors reduced the clinical and histological severity of DSS-induced colitis, as well as tissue levels of IL-6, IL-1beta and MMP-9.	dss	114-117	vasoactive intestinal peptide receptor 2	Mus musculus	32-40
21295288-6	2011	Thus VIP enhancement of the severity of DSS-induced colitis is mediated solely by VPAC1 receptors.	dss	40-43	vasoactive intestinal polypeptide	Mus musculus	5-8
21295288-6	2011	Thus VIP enhancement of the severity of DSS-induced colitis is mediated solely by VPAC1 receptors.	dss	40-43	vasoactive intestinal peptide receptor 1	Mus musculus	82-87
21062270-6	2011	The clinical and histological findings of colitis induced by 3 0% DSS solution were ameliorated significantly in mice treated with MIF-DNA vaccine compared with saline or pCAGGS-treated mice given DSS.	dss	66-69	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	131-134
21062270-7	2011	Myeloperoxidase activity, infiltration of F4/80-positive staining cells and the levels of proinflammatory cytokines were suppressed in the colon of MIF-DNA vaccine treated mice compared with saline or pCAGGS-treated mice exposed to DSS.	dss	232-235	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	148-151
21039426-8	2011	Mouse beta-defensin 3 (mBD-3, orthologue to hBD-2) was up-regulated strongly in colonic epithelium of 15-week-old IL-2(-/-) mice and DSS-induced colitis mice with chronic bowel inflammation, but not in apparently healthy IL-2(-/-) 5-week-old mice, IL-2(+/-) 15-week-old mice or in acute stage DSS mice.	dss	133-136	defensin beta 3	Mus musculus	23-28
21039426-8	2011	Mouse beta-defensin 3 (mBD-3, orthologue to hBD-2) was up-regulated strongly in colonic epithelium of 15-week-old IL-2(-/-) mice and DSS-induced colitis mice with chronic bowel inflammation, but not in apparently healthy IL-2(-/-) 5-week-old mice, IL-2(+/-) 15-week-old mice or in acute stage DSS mice.	dss	133-136	defensin beta 4A	Homo sapiens	44-49
21039426-8	2011	Mouse beta-defensin 3 (mBD-3, orthologue to hBD-2) was up-regulated strongly in colonic epithelium of 15-week-old IL-2(-/-) mice and DSS-induced colitis mice with chronic bowel inflammation, but not in apparently healthy IL-2(-/-) 5-week-old mice, IL-2(+/-) 15-week-old mice or in acute stage DSS mice.	dss	293-296	defensin beta 3	Mus musculus	6-21
21039426-8	2011	Mouse beta-defensin 3 (mBD-3, orthologue to hBD-2) was up-regulated strongly in colonic epithelium of 15-week-old IL-2(-/-) mice and DSS-induced colitis mice with chronic bowel inflammation, but not in apparently healthy IL-2(-/-) 5-week-old mice, IL-2(+/-) 15-week-old mice or in acute stage DSS mice.	dss	293-296	defensin beta 3	Mus musculus	23-28
21039426-11	2011	The mRNA expression level of the constitutively expressed alpha-defensin, cryptdin-4, was up-regulated marginally in acute stage DSS-colitis mice and in IL-2(-/-) mice before signs of colitis.	dss	129-132	defensin, alpha, 20	Mus musculus	74-84
20940665-7	2011	DSS mice also had smaller testes, lower FSH levels, increased systemic cytokines, and increased colonic inflammation by histology.	dss	0-3	follicle stimulating hormone beta	Mus musculus	40-43
22013382-6	2011	Upon DSS treatment, IL-17 production in lamina propria lymphocytes (LPLs) was induced, but ST28 significantly decreased its production.	dss	5-8	interleukin 17A	Mus musculus	20-25
22013382-7	2011	ST28 also decreased the percentage of Th17 cells in LPL from DSS-induced colitis.	dss	61-64	lipoprotein lipase	Mus musculus	52-55
20940665-9	2011	We conclude that DSS colitis causes delayed puberty in sexually immature male mice beyond what is seen among FR mice of similar weight, food intake, and leptin levels.	dss	17-20	leptin	Mus musculus	153-159
21858153-5	2011	METHODOLOGY/PRINCIPAL FINDINGS: Dextran sodium sulphate (DSS) administration induced acute colitis in C57BL/6 mice, as shown by significant weight loss, shortening of colon, mucosal ulceration, and increased presence of CXCR3(+) T cells as well as inflammatory cytokines.	dss	57-60	chemokine (C-X-C motif) receptor 3	Mus musculus	220-225
21949848-5	2011	Days 3-6 of DSS treatment were characterized by a prominent down regulation in the expression of regulatory cytokines (40-fold for IL-10 and TGFbeta) and mucin genes (15-18 fold for Muc2 and Muc3) concomitant with depletion of goblet cell and adherent mucin.	dss	12-15	interleukin 10	Rattus norvegicus	131-148
21949848-5	2011	Days 3-6 of DSS treatment were characterized by a prominent down regulation in the expression of regulatory cytokines (40-fold for IL-10 and TGFbeta) and mucin genes (15-18 fold for Muc2 and Muc3) concomitant with depletion of goblet cell and adherent mucin.	dss	12-15	solute carrier family 13 member 2	Rattus norvegicus	154-159
21949848-5	2011	Days 3-6 of DSS treatment were characterized by a prominent down regulation in the expression of regulatory cytokines (40-fold for IL-10 and TGFbeta) and mucin genes (15-18 fold for Muc2 and Muc3) concomitant with depletion of goblet cell and adherent mucin.	dss	12-15	mucin 2, oligomeric mucus/gel-forming	Rattus norvegicus	182-186
21949848-5	2011	Days 3-6 of DSS treatment were characterized by a prominent down regulation in the expression of regulatory cytokines (40-fold for IL-10 and TGFbeta) and mucin genes (15-18 fold for Muc2 and Muc3) concomitant with depletion of goblet cell and adherent mucin.	dss	12-15	mucin 3	Rattus norvegicus	191-195
21949848-5	2011	Days 3-6 of DSS treatment were characterized by a prominent down regulation in the expression of regulatory cytokines (40-fold for IL-10 and TGFbeta) and mucin genes (15-18 fold for Muc2 and Muc3) concomitant with depletion of goblet cell and adherent mucin.	dss	12-15	solute carrier family 13 member 2	Rattus norvegicus	252-257
20561896-0	2010	Antisecretory effects of neuropeptide Y in the mouse colon are region-specific and are lost in DSS-induced colitis.	dss	95-98	neuropeptide Y	Mus musculus	25-39
21887331-8	2011	In the multivariate analyses we found high tumor cell expression of PHD2 (HR = 2.03, CI 95% 1.20-3.42, P = 0.008) and PHD1 (HR = 1.45, CI 95% 1.01-2.10, P = 0.047) to be significant independent prognosticators for DSS.	dss	214-217	egl-9 family hypoxia inducible factor 1	Homo sapiens	68-72
20971730-3	2010	The objective of this study is to evaluate the role of interleukin (IL)-1beta in enhanced extra-intestinal thrombosis observed in mice with dextran sodium sulfate (DSS)-induced colitis.	dss	164-167	interleukin 1 beta	Mus musculus	55-77
21078994-5	2010	Compared with wild-type (WT) mice, IL-32gamma TG mice exhibited a modestly exacerbated acute inflammation early following the initiation of dextran sodium sulfate (DSS)-induced colitis.	dss	164-167	interleukin 32	Homo sapiens	35-45
21078994-9	2010	Constitutive levels of IL-32gamma itself in colonic tissues were significantly lower following DSS colitis.	dss	95-98	interleukin 32	Homo sapiens	23-33
20971730-7	2010	DSS-induced thrombogenesis was evaluated in WT mice treated with an IL-1beta antibody and in IL-1 receptor-deficient (IL-1r(-/-)) mice.	dss	0-3	interleukin 1 beta	Mus musculus	68-76
20971730-11	2010	DSS colitic mice treated with the IL-1beta antibody as well as IL-1r(-/-) mice exhibited significantly blunted thrombogenic responses.	dss	0-3	interleukin 1 beta	Mus musculus	34-42
20939013-16	2010	In a second model substituting organ-confined disease and lymph node status for TNM stage grouping, phosS6 and c-myc remained independent predictors of DSS (P=.03; HR, -0.21) and progression (P=.03; HR, -0.34), respectively.	dss	152-155	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-116
20127405-7	2010	AR expression was a significant marker of good prognosis for TTR (P = 0.001) and DSS (P &lt; 0.001).	dss	81-84	androgen receptor	Homo sapiens	0-2
20127405-9	2010	Cox models confirmed AR as an independent variable for both TTR (P = 0.003, HR 0.444, 95%CI 0.258-0.765) and DSS (P &lt; 0.001, HR 0.135, 95%CI 0.054-0.337).	dss	109-112	androgen receptor	Homo sapiens	21-23
20127405-11	2010	In this subset AR expression identified a group of patients with better prognosis for TTR (P = 0.017, HR 0.521, 95%CI 0.306-0.888) and DSS (P = 0.001, HR 0.276, 95% CI 0.130-0.588).	dss	135-138	androgen receptor	Homo sapiens	15-17
20667973-4	2010	BLT2(-/-) mice exhibited increased sensitivity to DSS as compared to wild-type and BLT1(-/-) mice, with more severe body weight loss and inflammation.	dss	50-53	leukotriene B4 receptor 2	Mus musculus	0-4
20667973-6	2010	Phosphorylation of the signal transducer and activator of transcription 3 (STAT3) was also markedly accelerated in the crypts of DSS-treated BLT2(-/-) mice.	dss	129-132	signal transducer and activator of transcription 3	Mus musculus	23-73
20667973-6	2010	Phosphorylation of the signal transducer and activator of transcription 3 (STAT3) was also markedly accelerated in the crypts of DSS-treated BLT2(-/-) mice.	dss	129-132	signal transducer and activator of transcription 3	Mus musculus	75-80
20667973-6	2010	Phosphorylation of the signal transducer and activator of transcription 3 (STAT3) was also markedly accelerated in the crypts of DSS-treated BLT2(-/-) mice.	dss	129-132	leukotriene B4 receptor 2	Mus musculus	141-145
20667973-8	2010	Thus, BLT2 is expressed in colon cryptic cells and appears to protect against DSS-induced colitis, possibly by enhancing barrier function in epithelial cells of the colon.	dss	78-81	leukotriene B4 receptor 2	Mus musculus	6-10
21102259-6	2010	RESULTS: The effect of EGFR-TKIs treatment on DSS showed a significant difference by TGFa and ARG (interaction p = 0.046 and p = 0.004, respectively).	dss	46-49	epidermal growth factor receptor	Homo sapiens	23-27
20600011-7	2010	Finally, PHD1 levels were increased with disease severity in intestinal tissue from patients with IBD and in colonic tissues from DSS-treated mice.	dss	130-133	egl-9 family hypoxia inducible factor 2	Homo sapiens	9-13
21102259-6	2010	RESULTS: The effect of EGFR-TKIs treatment on DSS showed a significant difference by TGFa and ARG (interaction p = 0.046 and p = 0.004, respectively).	dss	46-49	transforming growth factor alpha	Homo sapiens	85-89
21102259-7	2010	Low concentrations of TGFa and high concentrations of ARG were associated with a better DSS in EGFR-TKIs patients compared with control patients.	dss	88-91	transforming growth factor alpha	Homo sapiens	22-26
21102259-7	2010	Low concentrations of TGFa and high concentrations of ARG were associated with a better DSS in EGFR-TKIs patients compared with control patients.	dss	88-91	epidermal growth factor receptor	Homo sapiens	95-99
21102259-8	2010	Patients with high concentrations of IGF-binding protein-3 had significantly longer DSS, independent of treatment (hazard ratio: 0.60 per 1 mg/liter, 95% confidence interval: 0.46-0.79).	dss	84-87	insulin like growth factor binding protein 3	Homo sapiens	37-58
21041407-4	2010	Inactivation of YAP causes no obvious intestinal defects under normal homeostasis, but severely impairs DSS-induced intestinal regeneration.	dss	104-107	Yes1 associated transcriptional regulator	Homo sapiens	16-19
20884631-8	2010	Overall survival (OS) and disease-specific survival (DSS) were associated with the presence of TNFRSF14 mutation in patients whose overall treatment included rituximab.	dss	53-56	TNF receptor superfamily member 14	Homo sapiens	95-103
20884631-9	2010	We further showed that inferior OS and DSS were most pronounced in patients whose lymphomas contained both TNFRSF14 mutations and 1p36 deletions after adjustment for the International Prognostic Index [hazard ratios of 3.65 (95% confidence interval, 1.35-9.878, P=0.011) and 3.19 (95% confidence interval, 1.06-9.57, P=0.039), respectively].	dss	39-42	TNF receptor superfamily member 14	Homo sapiens	107-115
21067563-5	2010	Dextran sodium sulfate (DSS) colitis was induced in SAA 1/2 double knockout (DKO) mice and in wildtype controls.	dss	24-27	serum amyloid A 1	Mus musculus	52-57
20813914-4	2010	In healthy colonic mucosa, EP4 receptors were localized on apical plasma membrane of epithelial cells at the tip of mucosal folds, whereas, in patients with IBD and in rats with dextran sodium sulfate (DSS)-induced colitis, they were diffusely overexpressed throughout the mucosa.	dss	202-205	prostaglandin E receptor 4	Homo sapiens	27-30
20861238-4	2010	After 21 d of high salt intake, DSS, but not SD or DSR rats, exhibited vasopressin dysregulation, as evidenced by elevated plasma vasopressin levels (P &lt; 0.05), marked positive water (and sodium) balance (P &lt; 0.05), and an impaired diuretic response to pharmacological and physiological stimuli (P &lt; 0.05).	dss	32-35	arginine vasopressin	Rattus norvegicus	71-82
20861238-4	2010	After 21 d of high salt intake, DSS, but not SD or DSR rats, exhibited vasopressin dysregulation, as evidenced by elevated plasma vasopressin levels (P &lt; 0.05), marked positive water (and sodium) balance (P &lt; 0.05), and an impaired diuretic response to pharmacological and physiological stimuli (P &lt; 0.05).	dss	32-35	arginine vasopressin	Rattus norvegicus	130-141
20861238-6	2010	In salt-challenged (21 d) DSS rats, acute oligodeoxynucleotide-mediated down-regulation of central Galphaq proteins returned plasma vasopressin to control levels (P &lt; 0.05), decreased salt-induced water retention (P &lt; 0.05), and restored the profound diuretic responses to pharmacological and physiological stimuli (P &lt; 0.05).	dss	26-29	G protein subunit alpha q	Rattus norvegicus	99-106
20811697-5	2010	We then investigated the effect of inhibiting vascular endothelial growth factor (VEGFR)- and epidermal growth factor receptor (EGFR)-dependent signalling pathways on the development of adenomas induced in DSS-pretreated (DSS/Apc(MIN/+)) or non-DSS-pretreated (Apc(MIN/+)) mice using vandetanib (ZD6474), a potent and selective inhibitor of VEGFR and EGFR tyrosine kinase activity.	dss	206-209	epidermal growth factor receptor	Mus musculus	83-87
20811697-5	2010	We then investigated the effect of inhibiting vascular endothelial growth factor (VEGFR)- and epidermal growth factor receptor (EGFR)-dependent signalling pathways on the development of adenomas induced in DSS-pretreated (DSS/Apc(MIN/+)) or non-DSS-pretreated (Apc(MIN/+)) mice using vandetanib (ZD6474), a potent and selective inhibitor of VEGFR and EGFR tyrosine kinase activity.	dss	206-209	epidermal growth factor receptor	Mus musculus	128-132
20632386-12	2010	Our findings indicate that GDNF participates directly in restoring epithelial barrier function in vivo via reduction of increased epithelial permeability and inhibition of mucosal inflammatory response, and is efficacious in DSS-induced colitis.	dss	225-228	glial cell line derived neurotrophic factor	Mus musculus	27-31
21041407-5	2010	Conversely, hyperactivation of YAP results in widespread early-onset polyp formation following DSS treatment.	dss	95-98	Yes1 associated transcriptional regulator	Homo sapiens	31-34
20231854-3	2010	This study investigated whether the activation of the AhR pathway affects dextran sodium sulfate (DSS)-induced colitis, an ulcerative colitis-like model, in mice.	dss	98-101	aryl-hydrocarbon receptor	Mus musculus	54-57
20538086-1	2010	SHOX haploinsufficiency causes a wide spectrum of short stature phenotypes, such as Leri-Weill dyschondrosteosis (LWD) and disproportionate short stature (DSS).	dss	155-158	short stature homeobox	Homo sapiens	0-4
20538086-7	2010	Twelve patients (8 LWD and 4 DSS) had deletions in SHOX area detected by MLPA and 2 patients generated discordant results with the other methodologies.	dss	29-32	short stature homeobox	Homo sapiens	51-55
20222120-10	2010	RESULTS: Daily administration of CCL2 (60-120 ng) significantly decreased the development of TNBS- and DSS-induced colitis.	dss	103-106	chemokine (C-C motif) ligand 2	Mus musculus	33-37
20222120-11	2010	In a DSS-AOM model, CCL2-treated mice developed significantly fewer tumors (P &lt; 0.005) at 11 weeks.	dss	5-8	chemokine (C-C motif) ligand 2	Mus musculus	20-24
20222120-13	2010	CONCLUSIONS: Administration of pM levels of CCL2 significantly inhibits migration of T cells in amelioration of TNBS and DSS colitis and inhibits development of colorectal cancer in an AOM-DSS colitis model in mice.	dss	121-124	chemokine (C-C motif) ligand 2	Mus musculus	44-48
20339899-5	2010	RESULTS: Total deficiency of PAR(2) resulted in a marked reduction in severity of both TNBS and DSS induced colitis as assessed by MPO activity, macroscopic damage, bowel thickness, and leukocyte adherence.	dss	96-99	coagulation factor II (thrombin) receptor-like 1	Mus musculus	29-35
23562811-5	2013	Dextran sodium sulfate (DSS) exposure induced STAT-6 and NF-kappaB activation in mouse intestinal F4/80(+)CD11b(+)Ly6C(hi) (inflammatory) MPhis.	dss	24-27	signal transducer and activator of transcription 6	Mus musculus	46-52
23562811-5	2013	Dextran sodium sulfate (DSS) exposure induced STAT-6 and NF-kappaB activation in mouse intestinal F4/80(+)CD11b(+)Ly6C(hi) (inflammatory) MPhis.	dss	24-27	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
23562811-5	2013	Dextran sodium sulfate (DSS) exposure induced STAT-6 and NF-kappaB activation in mouse intestinal F4/80(+)CD11b(+)Ly6C(hi) (inflammatory) MPhis.	dss	24-27	integrin alpha M	Mus musculus	106-111
23562811-6	2013	DSS-induced CCL11 expression, eosinophilic inflammation, and histopathology were attenuated in RelA/p65(Deltamye) mice, but not in the absence of STAT-6.	dss	0-3	chemokine (C-C motif) ligand 11	Mus musculus	12-17
23562811-6	2013	DSS-induced CCL11 expression, eosinophilic inflammation, and histopathology were attenuated in RelA/p65(Deltamye) mice, but not in the absence of STAT-6.	dss	0-3	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	95-99
23562811-6	2013	DSS-induced CCL11 expression, eosinophilic inflammation, and histopathology were attenuated in RelA/p65(Deltamye) mice, but not in the absence of STAT-6.	dss	0-3	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	100-103
20411352-1	2010	The aim of this study was to investigate the involvement of transient receptor potential vanilloid 1 (TRPV1) receptors in oral dextran sulfate sodium-induced (DSS) colitis using TRPV1 knockout mice and their wild-type C57BL/6 counterparts.	dss	159-162	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-100
20411352-1	2010	The aim of this study was to investigate the involvement of transient receptor potential vanilloid 1 (TRPV1) receptors in oral dextran sulfate sodium-induced (DSS) colitis using TRPV1 knockout mice and their wild-type C57BL/6 counterparts.	dss	159-162	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	102-107
20411352-5	2010	In the 2% DSS-treated group, the lack of TRPV1 receptors decreased the DAI.	dss	10-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	41-46
20411352-9	2010	In conclusion, activation of TRPV1 channels enhances the clinical symptoms, histopathological changes, and neutrophil accumulation induced by 2% DSS.	dss	145-148	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
20624890-2	2010	In contrast, MyD88 signaling has a protective role in the development of azoxymethane (AOM)/dextran sodium sulfate (DSS) colitis-associated cancer (CAC).	dss	116-119	myeloid differentiation primary response gene 88	Mus musculus	13-18
20231854-4	2010	DSS-induced colitis was ameliorated by pretreatment with a potent AhR activator, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), in mice.	dss	0-3	aryl-hydrocarbon receptor	Mus musculus	66-69
20231854-6	2010	Collectively, the activation of the AhR pathway by TCDD may ameliorate DSS-induced colitis, at least in part, through PGE2 production.	dss	71-74	aryl-hydrocarbon receptor	Mus musculus	36-39
20442871-5	2010	DSS-induced translocation provoked LPS elevation only when phagocytic cells were depleted with clodronate liposomes (clodrolip).	dss	0-3	toll-like receptor 4	Mus musculus	35-38
20398663-5	2010	METHODS: We examined the susceptibility of Pirb-/- and wild-type (WT) mice to dextran sodium sulfate (DSS)-induced colitis.	dss	102-105	paired Ig-like receptor B	Mus musculus	43-47
20398663-7	2010	Macrophage transfer experiments were performed to define the role of PIR-B in the negative regulation of macrophage function in DSS-induced colitis.	dss	128-131	leukocyte immunoglobulin like receptor B1	Homo sapiens	69-74
20398663-9	2010	RESULTS: Pirb-/- mice had increased susceptibility to DSS-induced colitis.	dss	54-57	paired Ig-like receptor B	Mus musculus	9-13
20383640-10	2010	TNM stage (P &lt; 0.0001), age (P = 0.0043), and comorbidity (P = 0.0028) were independent variables for disease-specific survival (DSS) after cystectomy.	dss	132-135	teneurin transmembrane protein 1	Homo sapiens	0-3
20299601-12	2010	Loss of Fuc-TVII resulted in a reduction in disease severity whereas TFF3(-/-) mice were markedly more susceptible to DSS-induced colitis.	dss	118-121	trefoil factor 3, intestinal	Mus musculus	69-73
20299601-13	2010	Remarkably, the loss of Fuc-TVII in TFF3(-/-) mice markedly decreased the severity of DSS-induced colitis as evidenced by reduced weight loss, diarrhea, decreased colonic MPO levels and improved survival.	dss	86-89	fucosyltransferase 7	Mus musculus	24-32
20299601-13	2010	Remarkably, the loss of Fuc-TVII in TFF3(-/-) mice markedly decreased the severity of DSS-induced colitis as evidenced by reduced weight loss, diarrhea, decreased colonic MPO levels and improved survival.	dss	86-89	trefoil factor 3, intestinal	Mus musculus	36-40
20590633-6	2010	Following induction of mild colitis by DSS (2%), spinal c-Fos responses to AITC, but not vehicle, were augmented by 41%.	dss	39-42	FBJ osteosarcoma oncogene	Mus musculus	56-61
19904743-6	2010	Univariate analysis revealed that high expression of EZH2 was associated with poor metastasis-free survival (MFS) (p = 0.003), poor progression-free survival (PFS) (p = 0.001) and poor disease-specific survival (DSS) (p &lt; 0.001).	dss	212-215	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	53-57
19904743-7	2010	In multivariate analysis, high expression of EZH2, together with lack of clinical complete response, were evaluated as significant independent prognostic factors of MFS, PFS and DSS for patients with ESCC.	dss	178-181	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	45-49
20347874-0	2010	The absence of functional PI3Kgamma prevents leukocyte recruitment and ameliorates DSS-induced colitis in mice.	dss	83-86	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	26-35
20347874-6	2010	We induced colitis in mice with a point mutation that inactivates PI3Kgamma enzymatic activity ("kinase-dead") by oral administration of dextran sodium sulphate (DSS).	dss	162-165	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	66-75
20347874-10	2010	PI3Kgamma mutant mice showed increased numbers of resident macrophages and T cells in the colonic lamina propria in an unstressed condition but failed to recruit new leukocytes to the mucosa upon treatment with DSS despite the increased cytokine levels.	dss	211-214	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	0-9
20347874-11	2010	These results suggest that PI3Kgamma plays a critical role in lamina propria leukocyte trafficking and that loss of PI3Kgamma-activity ameliorates DSS-induced colitis in mice.	dss	147-150	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	116-125
19847812-5	2010	We show that iNOS is expressed in UM (57% of the patients) and high iNOS levels significantly (p = 0.04; hazard ratio (HR) = 2.3) predict disease-specific survival (DSS) as assessed by Kaplan-Meier analysis and univariate Cox"s proportional hazards regression model.	dss	165-168	nitric oxide synthase 2	Homo sapiens	13-17
19847812-5	2010	We show that iNOS is expressed in UM (57% of the patients) and high iNOS levels significantly (p = 0.04; hazard ratio (HR) = 2.3) predict disease-specific survival (DSS) as assessed by Kaplan-Meier analysis and univariate Cox"s proportional hazards regression model.	dss	165-168	nitric oxide synthase 2	Homo sapiens	68-72
19847812-9	2010	In conclusion, iNOS predicts DSS in UM and may play a role in disease progression but it is not an independent prognostic factor.	dss	29-32	nitric oxide synthase 2	Homo sapiens	15-19
20461082-6	2010	RESULTS: CAIX tissue overexpression correlated with shorter overall survival (OS) (P=0.05) and disease-specific survival (DSS) of patients (P=0.002).	dss	122-125	carbonic anhydrase 9	Homo sapiens	9-13
20461082-8	2010	A high level of CAIX in the plasma of patients was associated with shorter OS (P&lt;0.001) and DSS (P&lt;0.001), mostly in early stage I+II NSCLC.	dss	95-98	carbonic anhydrase 9	Homo sapiens	16-20
20423343-12	2010	CONCLUSIONS AND IMPLICATIONS: Although nicotine reduced cytokine responses in vitro, both selective alpha7 nAChR agonists worsened the effects of DSS-induced colitis or were ineffective in those of TNBS-induced colitis.	dss	146-149	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	100-112
20442871-6	2010	Macrophages of DSS-treated, HIV-negative mice phagocytosed more LPS ex vivo than those of control mice.	dss	15-18	toll-like receptor 4	Mus musculus	64-67
20422041-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: In the first phase, PPAR gamma flfl; Villin Cre- (VC-) and PPAR gamma flfl; Villin Cre+ (VC+) mice in a mixed FVB/C57BL/6 background were challenged with 2.5% dextran sodium sulfate (DSS) in drinking water for 0, 2, or 7 days.	dss	215-218	peroxisome proliferator activated receptor gamma	Mus musculus	52-62
19736360-8	2010	In DSS treated mice administration of xylan and BO-KGF had a significant therapeutic effect in reducing weight loss, improving stool consistency, reducing rectal bleeding, accelerating healing of damaged epithelium, reducing inflammation and neutrophil infiltration, reducing expression of pro-inflammatory cytokines, and accelerating production of goblet cells.	dss	3-6	fibroblast growth factor 7	Homo sapiens	51-54
20142801-12	2010	In addition, compared with PlGF(+/+) controls, PlGF(-/-) mice showed a significant increase in weight loss and colonic shortening during both DSS and TNBS colitis.	dss	142-145	placental growth factor	Mus musculus	47-51
20142801-15	2010	After the administration of DSS, strongly reduced mucosal angiogenesis was observed in PlGF(-/-) mice compared with PlGF(+/+) mice.	dss	28-31	placental growth factor	Mus musculus	87-91
20142801-15	2010	After the administration of DSS, strongly reduced mucosal angiogenesis was observed in PlGF(-/-) mice compared with PlGF(+/+) mice.	dss	28-31	placental growth factor	Mus musculus	116-120
20303296-4	2010	Here, we showed that mice deficient for Nlrp3 or ASC and caspase-1 were highly susceptible to dextran sodium sulfate (DSS)-induced colitis.	dss	118-121	NLR family, pyrin domain containing 3	Mus musculus	40-45
20303296-4	2010	Here, we showed that mice deficient for Nlrp3 or ASC and caspase-1 were highly susceptible to dextran sodium sulfate (DSS)-induced colitis.	dss	118-121	steroid sulfatase	Mus musculus	49-52
20303296-4	2010	Here, we showed that mice deficient for Nlrp3 or ASC and caspase-1 were highly susceptible to dextran sodium sulfate (DSS)-induced colitis.	dss	118-121	caspase 1	Mus musculus	57-66
19714745-0	2010	Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.	dss	67-70	immediate early response 3	Mus musculus	43-48
19647953-6	2010	RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) improved with IFRT in both the R-CHOP (p = 0.006 and 0.02, respectively) and CHOP (p = 0.02 and p = 0.04, respectively) groups.	dss	73-76	DNA damage inducible transcript 3	Homo sapiens	111-115
19647953-6	2010	RESULTS: The 5-year overall survival (OS) and disease-specific survival (DSS) improved with IFRT in both the R-CHOP (p = 0.006 and 0.02, respectively) and CHOP (p = 0.02 and p = 0.04, respectively) groups.	dss	73-76	DNA damage inducible transcript 3	Homo sapiens	155-159
19931259-10	2010	WT mice given transplants of ASK1(-/-) mouse-derived bone marrow cells developed more severe DSS-induced colitis than mice with WT-derived bone marrow cells.	dss	93-96	mitogen-activated protein kinase kinase kinase 5	Mus musculus	29-33
20072791-6	2010	RESULTS: DSS-treated mice exhibited later timing of vaginal opening relative to both of the other groups, as well as increased colonic inflammation by cytology and increased serum levels of interleukin (IL)-6 and tumor necrosis factor(TNF)-alpha.	dss	9-12	interleukin 6	Mus musculus	190-208
20072791-6	2010	RESULTS: DSS-treated mice exhibited later timing of vaginal opening relative to both of the other groups, as well as increased colonic inflammation by cytology and increased serum levels of interleukin (IL)-6 and tumor necrosis factor(TNF)-alpha.	dss	9-12	tumor necrosis factor	Mus musculus	213-245
20072791-8	2010	CONCLUSIONS: We conclude that DSS colitis causes delay in puberty in sexually immature mice beyond what would be expected from decreases in weight and leptin levels.	dss	30-33	leptin	Mus musculus	151-157
19940103-7	2010	Resveratrol also suppressed cyclooxygenase-2 (COX-2) expression induced in DSS-exposed mice.	dss	75-78	prostaglandin-endoperoxide synthase 2	Mus musculus	28-44
19940103-7	2010	Resveratrol also suppressed cyclooxygenase-2 (COX-2) expression induced in DSS-exposed mice.	dss	75-78	prostaglandin-endoperoxide synthase 2	Mus musculus	46-51
19906640-6	2010	This down-regulation of DSS and increased PSS was blocked by protein kinase C inhibition and SRPK1/2 inhibition.	dss	24-27	serine/arginine-rich protein specific kinase 1	Mus musculus	93-100
20677336-7	2010	Six-day treatment with lipophilic IAC significantly reduced intestinal damage caused by inflammation, induced a down-regulation in MPO activity (0.72 +/- 0.12 and 0.45 +/- 0.12 with lipophilic IAC po and ip, respectively, vs 1.10 +/- 0.27 in untreated DSS colitis animals) and minimized DSS-induced neutrophil infiltration, while hydrophilic IAC administered orally did not ameliorate DSS-induced damage.	dss	252-255	myeloperoxidase	Rattus norvegicus	131-134
20677336-7	2010	Six-day treatment with lipophilic IAC significantly reduced intestinal damage caused by inflammation, induced a down-regulation in MPO activity (0.72 +/- 0.12 and 0.45 +/- 0.12 with lipophilic IAC po and ip, respectively, vs 1.10 +/- 0.27 in untreated DSS colitis animals) and minimized DSS-induced neutrophil infiltration, while hydrophilic IAC administered orally did not ameliorate DSS-induced damage.	dss	287-290	myeloperoxidase	Rattus norvegicus	131-134
20677336-7	2010	Six-day treatment with lipophilic IAC significantly reduced intestinal damage caused by inflammation, induced a down-regulation in MPO activity (0.72 +/- 0.12 and 0.45 +/- 0.12 with lipophilic IAC po and ip, respectively, vs 1.10 +/- 0.27 in untreated DSS colitis animals) and minimized DSS-induced neutrophil infiltration, while hydrophilic IAC administered orally did not ameliorate DSS-induced damage.	dss	287-290	myeloperoxidase	Rattus norvegicus	131-134
20081110-4	2010	In Dahl salt-sensitive (DSS) rats, we found that high salt intake induced a time-dependent correlation of increased thiobarbituric acid reactive substances (TBARS, an indicator of lipid peroxidation) with reduced serum kallistatin levels.	dss	24-27	serpin family A member 4	Rattus norvegicus	219-230
19774646-8	2010	Moreover, we found that DSS colitis was more severe in TLR5(-/-) mice than wildtype C57BL/6 mice.	dss	24-27	toll-like receptor 5	Mus musculus	55-59
20001759-8	2010	In a similar Cox model, disease recurrence and the number of metastatic lymph nodes were independent predictors of DSS.	dss	115-118	cytochrome c oxidase subunit 8A	Homo sapiens	13-16
19688830-4	2010	At Week 18, the development of colonic adenocarcinoma was significantly inhibited by feeding with GOFA/beta-CD at dose levels of 100 ppm (63% reduction in multiplicity, p &lt; 0.05) and 500 ppm (83% reduction in the multiplicity, p &lt; 0.001), when compared with the AOM/DSS group (multiplicity: 3.36 +/- 3.34).	dss	272-275	beta-carotene oxygenase 1	Mus musculus	103-110
19714745-0	2010	Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.	dss	67-70	immediate early response 3	Mus musculus	12-17
19735476-8	2010	CaM kinase II activity and cytosolic levels of HDAC4 were increased, and I kappaB alpha levels were decreased in distal colon smooth muscles from DSS-treated mice.	dss	146-149	histone deacetylase 4	Mus musculus	47-52
19735476-8	2010	CaM kinase II activity and cytosolic levels of HDAC4 were increased, and I kappaB alpha levels were decreased in distal colon smooth muscles from DSS-treated mice.	dss	146-149	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	73-87
20084281-3	2010	Unexpectedly, we found a CD97 cDNA copy number-dependent reduction of DSS-induced colitis in Tg compared to wild-type (WT) mice that was confirmed by applying a simple DSS protocol.	dss	70-73	adhesion G protein-coupled receptor E5	Mus musculus	25-29
20084281-3	2010	Unexpectedly, we found a CD97 cDNA copy number-dependent reduction of DSS-induced colitis in Tg compared to wild-type (WT) mice that was confirmed by applying a simple DSS protocol.	dss	168-171	adhesion G protein-coupled receptor E5	Mus musculus	25-29
20008145-3	2010	The aim of this study was to investigate the role of Sdc1 in murine dextran sodium sulfate (DSS)-induced colitis.	dss	92-95	syndecan 1	Mus musculus	53-57
20008145-7	2010	Treatment from days 7 through 14 with enoxaparin, a functional analogue of the Sdc1 heparan sulfate chains, significantly reduced lethality of KO mice due to DSS-induced colitis, which was correlated with improved mucosal healing.	dss	158-161	syndecan 1	Mus musculus	79-83
20826917-12	2010	CONCLUSIONS: Increased number of PD-1+ tumor-infiltrating lymphocytes is associated with significantly improved DSS in FL and may be useful to predict its heterogeneous clinical behavior.	dss	112-115	programmed cell death 1	Homo sapiens	33-37
19714745-0	2010	Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.	dss	67-70	immediate early response 3	Mus musculus	49-54
19714745-0	2010	Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.	dss	67-70	immediate early response 3	Mus musculus	43-48
19714745-0	2010	Ablation of gly96/immediate early gene-X1 (gly96/iex-1) aggravates DSS-induced colitis in mice: role for gly96/iex-1 in the regulation of NF-kappaB.	dss	67-70	immediate early response 3	Mus musculus	111-116
19714745-7	2010	The expression of proinflammatory chemo- and cytokines was higher in the colon of DSS-treated gly96/iex-1(-/-) mice, and the NF-kappaB activation was enhanced particularly in the distal colon.	dss	82-85	immediate early response 3	Mus musculus	94-99
19714745-7	2010	The expression of proinflammatory chemo- and cytokines was higher in the colon of DSS-treated gly96/iex-1(-/-) mice, and the NF-kappaB activation was enhanced particularly in the distal colon.	dss	82-85	immediate early response 3	Mus musculus	100-105
19714745-7	2010	The expression of proinflammatory chemo- and cytokines was higher in the colon of DSS-treated gly96/iex-1(-/-) mice, and the NF-kappaB activation was enhanced particularly in the distal colon.	dss	82-85	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
19572375-11	2010	RESULTS: Vanin-1(-/-) mice displayed a drastically reduced incidence of colorectal cancer in the CAC protocol and manifested mild clinical signs of DSS-induced colitis.	dss	148-151	vanin 1	Mus musculus	9-16
19828878-7	2010	The DSS-induced overproduction of colonic proinflammatory cytokines including interleukin (IL)-1beta, tumor necrosis factor-alpha, and interferon-gamma was significantly suppressed in mice undergoing AS605240 therapy, whereas colonic anti-inflammatory cytokines such as IL-4 were up-regulated.	dss	4-7	interferon gamma	Mus musculus	135-151
19828878-7	2010	The DSS-induced overproduction of colonic proinflammatory cytokines including interleukin (IL)-1beta, tumor necrosis factor-alpha, and interferon-gamma was significantly suppressed in mice undergoing AS605240 therapy, whereas colonic anti-inflammatory cytokines such as IL-4 were up-regulated.	dss	4-7	interleukin 4	Mus musculus	270-274
19956864-5	2010	FBRA administration suppressed the cell proliferative index, which is accompanied by the significantly decreased mRNA expressions of Cox2 and iNos in colonic mucosa exposed to DSS (p&lt;0.04 and 0.02, respectively).	dss	176-179	cytochrome c oxidase II, mitochondrial	Mus musculus	133-137
19956864-5	2010	FBRA administration suppressed the cell proliferative index, which is accompanied by the significantly decreased mRNA expressions of Cox2 and iNos in colonic mucosa exposed to DSS (p&lt;0.04 and 0.02, respectively).	dss	176-179	nitric oxide synthase 2, inducible	Mus musculus	142-146
20025479-7	2010	Moreover, at the univariate level, ANXA1 overexpression, along with higher pT status and histological grade, significantly predicted disease-specific survival (DSS) and metastasis-free survival (MFS).	dss	160-163	annexin A1	Homo sapiens	35-40
20025479-8	2010	More importantly, multivariate analyses revealed that the association of ANXA1 overexpression and prognosis remained significant for both DSS and MFS.	dss	138-141	annexin A1	Homo sapiens	73-78
19732774-1	2009	BACKGROUND &amp; AIMS: The protective component of the host response to dextran sodium sulfate (DSS)-induced colitis in the mouse is mediated through the activation of Toll-like receptor (TLR) 4, the induction of cyclooxygenase (COX)-2, and prostaglandin E(2) production.	dss	96-99	cytochrome c oxidase II, mitochondrial	Mus musculus	213-235
19836225-2	2010	Decision support systems (DSS) can be utilized to handle these complex interactions and to aid in a performance-based landfill design by coupling system simulation models (SSM).	dss	26-29	activation induced cytidine deaminase	Homo sapiens	91-94
19893035-7	2009	Transfer of bone marrow cells from wild-type mice reconstituted disease manifestation in DSS-treated DeltadblGATA-1 mice, and levels of CCL11 were increased after DSS treatment and localized to inflammatory cells.	dss	163-166	chemokine (C-C motif) ligand 11	Mus musculus	136-141
19732774-13	2009	Furthermore, exogenous hyaluronic acid, through the activation of TLRs and the production of prostaglandin E(2) through COX-2, has protective effects in DSS-induced colitis.	dss	153-156	cytochrome c oxidase II, mitochondrial	Mus musculus	120-125
19732774-8	2009	Treatment with DSS also induced the MyD88-dependent expression of hyaluronic acid synthases 2 and 3, enzymes involved in hyaluronic acid synthesis, in lamina propria macrophages.	dss	15-18	hyaluronan synthase 2	Mus musculus	66-99
19821118-1	2009	The aim of this study was to investigate the cellular and molecular expression of tartrate resistant acid phosphatase (TRAP) as a marker of activated macrophages in macrophage dependent dextran sulphate sodium (DSS)-induced colitis in rats.	dss	211-214	acid phosphatase 5, tartrate resistant	Rattus norvegicus	82-117
20084676-7	2010	RESULTS: : DAI, MPO and histological inflammation scores were significantly increased in all animals treated with DSS.	dss	114-117	myeloperoxidase	Rattus norvegicus	16-19
19388987-15	2009	Age at diagnosis and ADT induction, PSA level before ADT, and disease stage predict both OS and DSS in this population.	dss	96-99	aminopeptidase puromycin sensitive	Homo sapiens	36-39
19821118-1	2009	The aim of this study was to investigate the cellular and molecular expression of tartrate resistant acid phosphatase (TRAP) as a marker of activated macrophages in macrophage dependent dextran sulphate sodium (DSS)-induced colitis in rats.	dss	211-214	acid phosphatase 5, tartrate resistant	Rattus norvegicus	119-123
19821118-7	2009	In conclusion, induction of TRAP provides an early sign of macrophage responsiveness in DSS induced colitis.	dss	88-91	acid phosphatase 5, tartrate resistant	Rattus norvegicus	28-32
19570553-7	2009	Plasma gammaMSH and renal MC3-R abundance in DSS rats were maximally elevated on low-salt diet and remained unchanged on high-salt diet.	dss	45-48	melanocortin 3 receptor	Rattus norvegicus	26-31
19846969-7	2009	In univariate analyses, high tumor epithelial cell expression of non-phosphorylated Akt2 (p=0.014) was a positive prognostic indicator for disease-specific survival (DSS), while high tumor epithelial cell expression of p-Akt Thr(308) (p=0.045) was a negative prognosticator.	dss	166-169	AKT serine/threonine kinase 2	Homo sapiens	84-88
19846969-7	2009	In univariate analyses, high tumor epithelial cell expression of non-phosphorylated Akt2 (p=0.014) was a positive prognostic indicator for disease-specific survival (DSS), while high tumor epithelial cell expression of p-Akt Thr(308) (p=0.045) was a negative prognosticator.	dss	166-169	AKT serine/threonine kinase 1	Homo sapiens	84-87
19570553-10	2009	Thus, the data suggest that gammaMSH-renal MC3-R pathway is activated and appears to be biologically functional in the DSS rats.	dss	119-122	melanocortin 3 receptor	Rattus norvegicus	43-48
19522853-6	2009	Patients with BRCA1 methylated tumors had a significantly worse 5-year disease-free survival (DFS) and 5-year disease-specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2%vs 82.6%, P = 0.045; DSS 80.5%vs 87%, P = 0.038, two-sided).	dss	137-140	BRCA1 DNA repair associated	Homo sapiens	14-19
20137697-7	2009	The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P &lt; 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml].	dss	80-83	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	28-31
20137697-7	2009	The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P &lt; 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml].	dss	80-83	tumor necrosis factor	Mus musculus	36-45
20137697-7	2009	The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P &lt; 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml].	dss	80-83	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	157-160
20137697-7	2009	The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P &lt; 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml].	dss	246-249	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	28-31
20137697-7	2009	The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P &lt; 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml].	dss	246-249	tumor necrosis factor	Mus musculus	36-45
20137697-7	2009	The expression of NF-kappaB p65 and TNF-alpha [(266 +/- 35) pg/ml] in mice with DSS-induced colitis was significantly reduced after treatment with NF-kappaB p65 siRNA (P &lt; 0.05) in comparisons with the scrambled siRNA [(412 +/- 51) pg/ml] and DSS group pg/ml [(449 +/- 44) pg/ml].	dss	246-249	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	157-160
19552757-7	2009	Univariate analysis revealed that AIB1 overexpression was associated with poor progression-free survival (PFS) (P &lt; 0.001) and poor disease-specific survival (DSS) (P &lt;0.001).	dss	162-165	HEAT repeat containing 6	Homo sapiens	34-38
19552757-8	2009	Furthermore, AIB1 expression could stratify patient survival in stages T2-3, T4, N1, and M0 (P &lt; 0.05), as well as in the CRT effective group (P &lt; 0.05), and AIB1 overexpression and CRT resistance were evaluated as significant independent prognostic factors for both PFS and DSS in multivariate analysis.	dss	281-284	HEAT repeat containing 6	Homo sapiens	13-17
19522853-6	2009	Patients with BRCA1 methylated tumors had a significantly worse 5-year disease-free survival (DFS) and 5-year disease-specific survival (DSS) than did patients with unmethylated tumors (DFS: 73.2%vs 82.6%, P = 0.045; DSS 80.5%vs 87%, P = 0.038, two-sided).	dss	217-220	BRCA1 DNA repair associated	Homo sapiens	14-19
19723145-6	2009	On univariate analysis, increasing numbers of stromal CD1a+ (P = 0.011) and CD56+ cells (P = 0.014) correlated significantly with improved disease-specific survival (DSS).	dss	166-169	CD1a molecule	Homo sapiens	54-58
19723145-6	2009	On univariate analysis, increasing numbers of stromal CD1a+ (P = 0.011) and CD56+ cells (P = 0.014) correlated significantly with improved disease-specific survival (DSS).	dss	166-169	neural cell adhesion molecule 1	Homo sapiens	76-80
19723145-7	2009	On multivariate analysis, stromal CD56+ cells were an independent prognostic factor for DSS (hazard ratio = 2.3, confidence interval = 1.1, 5.0, P = 0.031).	dss	88-91	neural cell adhesion molecule 1	Homo sapiens	34-38
19486890-3	2009	At day-7, DSS-induced pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-alpha and IL-1beta in colon lesion, were significantly suppressed by the addition of H2 to DSS solution.	dss	10-13	tumor necrosis factor	Mus musculus	165-174
19486890-3	2009	At day-7, DSS-induced pathogenic outcomes including, loss of body weight, increase of colitis score, pathogenic shortening of colon length, elevated level of IL-12, TNF-alpha and IL-1beta in colon lesion, were significantly suppressed by the addition of H2 to DSS solution.	dss	10-13	interleukin 1 beta	Mus musculus	179-187
19276398-10	2009	The same was true with disease-specific survival (DSS), patients with PLA2-negative tumors living significantly longer (P = 0.025).	dss	50-53	phospholipase A2 group IIA	Homo sapiens	70-74
19521735-8	2009	In multivariate analyses, while controlling for age, ER status, tumor grade, stage, and treatment, ECM1 expression emerged as a significant predictor of DSS (hazard ratios, 4.16 (P = 0.009) and 11.6 (P = 0.01) at 10 and 15 years, respectively) and DFS (hazard ratio, 3.08 (P = 0.03) at 15 years) with ECM1 overexpression predicting poorer survival.	dss	153-156	extracellular matrix protein 1	Homo sapiens	99-103
19521735-9	2009	CONCLUSIONS: ECM1 was overexpressed in approximately half of invasive breast carcinomas and is an important prognostic marker, particularly for predicting poorer DSS, with its predictive value increasing with time from diagnosis.	dss	162-165	extracellular matrix protein 1	Homo sapiens	13-17
19034653-7	2009	ROS in the colon, the level of interleukin 1 beta (IL-1 beta) in colonic mucosa, serum tumor necrosis factor a (TNF-alpha), MPO, and MDA were significantly increased in DSS-treated animals (P &lt; 0.01), with decreased PON1 activity (P &lt; 0.01).	dss	169-172	interleukin 1 beta	Mus musculus	31-49
19034653-7	2009	ROS in the colon, the level of interleukin 1 beta (IL-1 beta) in colonic mucosa, serum tumor necrosis factor a (TNF-alpha), MPO, and MDA were significantly increased in DSS-treated animals (P &lt; 0.01), with decreased PON1 activity (P &lt; 0.01).	dss	169-172	interleukin 1 beta	Mus musculus	51-60
19034653-7	2009	ROS in the colon, the level of interleukin 1 beta (IL-1 beta) in colonic mucosa, serum tumor necrosis factor a (TNF-alpha), MPO, and MDA were significantly increased in DSS-treated animals (P &lt; 0.01), with decreased PON1 activity (P &lt; 0.01).	dss	169-172	tumor necrosis factor	Mus musculus	112-121
19034653-7	2009	ROS in the colon, the level of interleukin 1 beta (IL-1 beta) in colonic mucosa, serum tumor necrosis factor a (TNF-alpha), MPO, and MDA were significantly increased in DSS-treated animals (P &lt; 0.01), with decreased PON1 activity (P &lt; 0.01).	dss	169-172	myeloperoxidase	Mus musculus	124-127
19034653-7	2009	ROS in the colon, the level of interleukin 1 beta (IL-1 beta) in colonic mucosa, serum tumor necrosis factor a (TNF-alpha), MPO, and MDA were significantly increased in DSS-treated animals (P &lt; 0.01), with decreased PON1 activity (P &lt; 0.01).	dss	169-172	paraoxonase 1	Mus musculus	219-223
19396818-10	2009	On univariate analysis of all patients, high EphA2 expression was associated significantly with shorter disease-specific survival (DSS) (P &lt; .001).	dss	131-134	EPH receptor A2	Homo sapiens	45-50
19396818-11	2009	On multivariate analysis, age (P &lt; .001), high disease stage (P = .002), and high EphA2 expression (P = .04) were independent predictors of poor DSS.	dss	148-151	EPH receptor A2	Homo sapiens	85-90
19359427-10	2009	Blocking TLR4 at the beginning of DSS administration delayed the development of colitis with significantly lower DAI scores.	dss	34-37	toll-like receptor 4	Mus musculus	9-13
19359427-12	2009	Anti-TLR4 Ab treatment during recovery from DSS colitis resulted in defective mucosal healing with lower expression of COX-2, PGE(2), and amphiregulin.	dss	44-47	toll-like receptor 4	Mus musculus	5-9
19359427-12	2009	Anti-TLR4 Ab treatment during recovery from DSS colitis resulted in defective mucosal healing with lower expression of COX-2, PGE(2), and amphiregulin.	dss	44-47	cytochrome c oxidase II, mitochondrial	Mus musculus	119-124
19359427-12	2009	Anti-TLR4 Ab treatment during recovery from DSS colitis resulted in defective mucosal healing with lower expression of COX-2, PGE(2), and amphiregulin.	dss	44-47	amphiregulin	Mus musculus	138-150
18978179-3	2009	AIM: To investigate the ability of interleukin 2 (IL2)-caspase 3 chimeric protein, designed to target activated T lymphocytes that express the high-affinity IL2 receptor, to ameliorate the clinical symptoms of acute murine experimental colitis, using a mouse model of dextran sodium sulfate (DSS)-induced colitis.	dss	292-295	interleukin 2	Mus musculus	35-48
18978179-3	2009	AIM: To investigate the ability of interleukin 2 (IL2)-caspase 3 chimeric protein, designed to target activated T lymphocytes that express the high-affinity IL2 receptor, to ameliorate the clinical symptoms of acute murine experimental colitis, using a mouse model of dextran sodium sulfate (DSS)-induced colitis.	dss	292-295	interleukin 2	Mus musculus	50-53
18978179-4	2009	METHODS: Mice with DSS-induced colitis were treated with IL2-caspase 3 for 7 days and disease severity was assessed in parallel to control, non-treated mice, receiving only daily injections of phosphate-buffered saline.	dss	19-22	interleukin 2	Mus musculus	57-60
18978179-4	2009	METHODS: Mice with DSS-induced colitis were treated with IL2-caspase 3 for 7 days and disease severity was assessed in parallel to control, non-treated mice, receiving only daily injections of phosphate-buffered saline.	dss	19-22	caspase 3	Mus musculus	61-70
19403332-10	2009	ASD worsened colonic inflammation: tissue MPO levels in ASD/DSS-treated mice were significantly higher than in DSS-treated mice that were not sleep deprived.	dss	60-63	myeloperoxidase	Mus musculus	42-45
19778214-4	2009	DSS significantly improved the axonal degeneration, the ratio of myelinated nerves &lt; 3 microm in diameter, degree of central chromatolysis of the ganglion neurons in peripheral nerves, and numbers of SYP (+) aberrant dots per mm cortex in the cerebellar molecular layer of ACR-treated rats no matter before, after, or during ACR-exposure (p &lt; 0.05).	dss	0-3	synaptophysin	Rattus norvegicus	203-206
19362884-9	2009	In multivariate, random-effects linear models adjusted for age, education, gender, and race, the risk factors diabetes and APOE epsilon4 genotype were independently associated with a decline in performance on the DSS test (both P &lt; .005), whereas hypertension and stroke were not.	dss	213-216	apolipoprotein E	Homo sapiens	123-127
19299581-4	2009	In vivo, dextran sodium sulfate (DSS) colitis was induced in wild-type (WT) and villin-promoter regulated "UTR-less" Hsp70 transgenic (TG) mice, the latter exhibiting intestinal epithelial-specific transgene expression.	dss	33-36	heat shock protein 1B	Mus musculus	117-122
19299581-6	2009	Hsp70 TG mice demonstrated significantly lower endoscopic and histological inflammation scores in DSS-induced colitis than WT.	dss	98-101	heat shock protein 1B	Mus musculus	0-5
19202571-1	2009	BACKGROUND: Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the effects potentially mediated by the vasoconstrictor endothelin-1 (ET-1).	dss	57-60	endothelin 1	Mus musculus	182-194
19202571-1	2009	BACKGROUND: Ingestion by mice of dextran sodium sulfate (DSS) induces colonic vasoconstriction and inflammation, with some of the effects potentially mediated by the vasoconstrictor endothelin-1 (ET-1).	dss	57-60	endothelin 1	Mus musculus	196-200
19202571-2	2009	METHODS: In this study, mice given 5% 40 kD DSS for 5-6 days had elevated colonic immunostaining for ET-1 and platelet endothelial cell adhesion molecule-1 (PECAM-1).	dss	44-47	endothelin 1	Mus musculus	101-105
19202571-2	2009	METHODS: In this study, mice given 5% 40 kD DSS for 5-6 days had elevated colonic immunostaining for ET-1 and platelet endothelial cell adhesion molecule-1 (PECAM-1).	dss	44-47	platelet/endothelial cell adhesion molecule 1	Mus musculus	110-155
19202571-2	2009	METHODS: In this study, mice given 5% 40 kD DSS for 5-6 days had elevated colonic immunostaining for ET-1 and platelet endothelial cell adhesion molecule-1 (PECAM-1).	dss	44-47	platelet/endothelial cell adhesion molecule 1	Mus musculus	157-164
19202571-5	2009	Daily administration of the endothelin converting enzyme inhibitor SM-19712 (15 mg/kg) attenuated DSS-induced increases in colonic immunostaining of ET-1 and PECAM-1.	dss	98-101	endothelin 1	Mus musculus	149-153
19202571-5	2009	Daily administration of the endothelin converting enzyme inhibitor SM-19712 (15 mg/kg) attenuated DSS-induced increases in colonic immunostaining of ET-1 and PECAM-1.	dss	98-101	platelet/endothelial cell adhesion molecule 1	Mus musculus	158-165
19474676-8	2009	The 5 years DSS for localized tumor patients was 35% for NF-1 patients and 50% for sporadic patients.	dss	12-15	neurofibromin 1	Homo sapiens	57-61
19474676-11	2009	Only tumor size and nuclear p53 expression were found to be independent prognosticators for MPNST DSS in a multivariable analysis.	dss	98-101	tumor protein p53	Homo sapiens	28-31
18627421-3	2009	We found considerably raised OPN levels in blood of wild-type (WT) mice with dextran sodium sulfate (DSS)-induced colitis.	dss	101-104	secreted phosphoprotein 1	Mus musculus	29-32
19243813-6	2009	Nuclear MB1 expression was an independent predictor of worse DSS (HR 1.94, 95% CI 1.16-3.26, p=0.012).	dss	61-64	proteasome 20S subunit beta 5	Homo sapiens	8-11
19243813-8	2009	Median DSS was longer for patients with normal nuclear expression of LMP7 (57.4 vs. 31.0 months, p=0.029).	dss	7-10	proteasome 20S subunit beta 8	Homo sapiens	69-73
19067430-8	2009	C57BL/6.mdr1a-deficient animals demonstrated increased histological inflammation, colonic shortening, fecal blood, and reduced body weight after 7 days of treatment with 2.25% DSS.	dss	176-179	ATP-binding cassette, sub-family B (MDR/TAP), member 1A	Mus musculus	8-13
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	dss	56-59	heat shock protein family B (small) member 1	Homo sapiens	5-10
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	dss	56-59	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	16-23
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	dss	56-59	NFKB inhibitor alpha	Homo sapiens	75-83
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	dss	56-59	nuclear factor kappa B subunit 1	Homo sapiens	85-93
19085995-0	2009	ROS, Hsp27, and IKKbeta mediate dextran sodium sulfate (DSS) activation of IkappaBa, NFkappaB, and IL-8.	dss	56-59	C-X-C motif chemokine ligand 8	Homo sapiens	99-103
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	NFKB inhibitor alpha	Homo sapiens	42-54
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	nuclear factor kappa B subunit 1	Homo sapiens	64-72
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	RELA proto-oncogene, NF-kB subunit	Homo sapiens	74-77
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	84-88
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	toll like receptor 4	Homo sapiens	255-259
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	MYD88 innate immune signal transduction adaptor	Homo sapiens	261-266
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	BCL10 immune signaling adaptor	Homo sapiens	271-276
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	nuclear factor kappa B subunit 1	Homo sapiens	333-341
19085995-3	2009	METHODS: DSS-induced increases in phospho-IkappaBalpha, nuclear NFkappaB (p65), and IL-8 secretion in human colonic epithelial cells in tissue culture are attributable to a reactive oxygen species (ROS)-induced pathway of inflammation, and do not require TLR4, MyD88, or Bcl10, which are associated with the innate immune pathway of NFkappaB-IL-8 activation.	dss	9-12	C-X-C motif chemokine ligand 8	Homo sapiens	342-346
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	dss	9-12	mitogen-activated protein kinase 12	Homo sapiens	136-142
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	dss	9-12	mitogen-activated protein kinase 12	Homo sapiens	144-152
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	dss	9-12	mitogen-activated protein kinase 13	Homo sapiens	155-162
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	dss	9-12	mitogen-activated protein kinase 13	Homo sapiens	164-172
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	dss	9-12	heat shock protein family B (small) member 1	Homo sapiens	179-184
19085995-4	2009	RESULTS: DSS-induced increases were inhibited by the ROS scavengers Tempol and Tiron, were associated with decreased phosphorylation of MAPK12 (p38gamma), MAPK 13 (p38delta), and Hsp27, and required the IkappaB kinase (IKK) signalosome component IKKbeta.	dss	9-12	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	246-253
19085995-6	2009	Data demonstrated that DSS activates IkappaBalpha, NFkappaB, and IL-8 through an ROS-Hsp27-IKKbeta-mediated pathway, and not through an innate immune cascade.	dss	23-26	NFKB inhibitor alpha	Homo sapiens	37-49
19085995-6	2009	Data demonstrated that DSS activates IkappaBalpha, NFkappaB, and IL-8 through an ROS-Hsp27-IKKbeta-mediated pathway, and not through an innate immune cascade.	dss	23-26	nuclear factor kappa B subunit 1	Homo sapiens	51-59
19085995-6	2009	Data demonstrated that DSS activates IkappaBalpha, NFkappaB, and IL-8 through an ROS-Hsp27-IKKbeta-mediated pathway, and not through an innate immune cascade.	dss	23-26	C-X-C motif chemokine ligand 8	Homo sapiens	65-69
19085995-6	2009	Data demonstrated that DSS activates IkappaBalpha, NFkappaB, and IL-8 through an ROS-Hsp27-IKKbeta-mediated pathway, and not through an innate immune cascade.	dss	23-26	heat shock protein family B (small) member 1	Homo sapiens	85-90
19085995-6	2009	Data demonstrated that DSS activates IkappaBalpha, NFkappaB, and IL-8 through an ROS-Hsp27-IKKbeta-mediated pathway, and not through an innate immune cascade.	dss	23-26	inhibitor of nuclear factor kappa B kinase subunit beta	Homo sapiens	91-98
19131582-3	2009	To begin to understand the mechanism, we determined the role of the PMN chemokine receptor, CXCR2, in DSS-induced colitis by using CXCR2(-/-) mice or by neutralizing CXCR2.	dss	102-105	chemokine (C-X-C motif) receptor 2	Mus musculus	92-97
19342675-10	2009	Taken together, these studies indicate a central regulatory role for AA2BR-modulated IL-10 in the acute inflammatory phase of DSS colitis, thereby implicating AA2BR as an endogenously protective molecule expressed on intestinal epithelial cells.	dss	126-129	adenosine A2b receptor	Mus musculus	69-74
19342675-10	2009	Taken together, these studies indicate a central regulatory role for AA2BR-modulated IL-10 in the acute inflammatory phase of DSS colitis, thereby implicating AA2BR as an endogenously protective molecule expressed on intestinal epithelial cells.	dss	126-129	interleukin 10	Mus musculus	85-90
19342675-10	2009	Taken together, these studies indicate a central regulatory role for AA2BR-modulated IL-10 in the acute inflammatory phase of DSS colitis, thereby implicating AA2BR as an endogenously protective molecule expressed on intestinal epithelial cells.	dss	126-129	adenosine A2b receptor	Mus musculus	159-164
19179628-5	2009	We observed that the NF-kappaB pathway is activated in colonic epithelia from DSS-administered mice in association with upregulation of TNFR2 rather than TNFR1.	dss	78-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30
19179628-5	2009	We observed that the NF-kappaB pathway is activated in colonic epithelia from DSS-administered mice in association with upregulation of TNFR2 rather than TNFR1.	dss	78-81	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	136-141
19179628-5	2009	We observed that the NF-kappaB pathway is activated in colonic epithelia from DSS-administered mice in association with upregulation of TNFR2 rather than TNFR1.	dss	78-81	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	154-159
19179628-6	2009	Immunoblot analysis also revealed that the TNFR2 upregulation accompanied by the NF-kappaB activation is further complicated in CAC tissues induced in AOM/DSS-administered mice compared with the nontumor area.	dss	155-158	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	43-48
19179628-6	2009	Immunoblot analysis also revealed that the TNFR2 upregulation accompanied by the NF-kappaB activation is further complicated in CAC tissues induced in AOM/DSS-administered mice compared with the nontumor area.	dss	155-158	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	81-90
19380103-8	2009	DSS and BMH each inhibited KCC1-mediated (86)Rb(+) uptake stimulated by hypotonicity or by N-ethylmaleimide (NEM) without reduction in nominal surface abundance of KCC1.	dss	0-3	solute carrier family 12, member 4	Mus musculus	27-31
19131582-4	2009	DSS was administered through drinking water to CXCR2(-/-) and BALB/c mice for 5 days followed by regular water for 1 day.	dss	0-3	chemokine (C-X-C motif) receptor 2	Mus musculus	47-52
19131582-11	2009	Our experiments identify a role for CXCR2 in DSS-induced colitis and suggest that antagonizing CXCR2 provides some therapeutic efficacy, possibly by impeding PMN recruitment into the mucosa.	dss	45-48	chemokine (C-X-C motif) receptor 2	Mus musculus	36-41
19204576-7	2009	Inversely, high basic fibroblast growth factor (bFGF) expression in stroma was associated with significantly improved DSS (p = 0.017).	dss	118-121	fibroblast growth factor 2	Homo sapiens	16-46
19204576-7	2009	Inversely, high basic fibroblast growth factor (bFGF) expression in stroma was associated with significantly improved DSS (p = 0.017).	dss	118-121	fibroblast growth factor 2	Homo sapiens	48-52
19204576-8	2009	In multivariate analyses, tumor PDGF expression appeared independently associated with a shorter DSS (hazard ratio 5.42, p = 0.002) and stromal bFGF expression an increased DSS (hazard ratio 0.077, p &lt; 0.001).	dss	173-176	fibroblast growth factor 2	Homo sapiens	144-148
19131582-11	2009	Our experiments identify a role for CXCR2 in DSS-induced colitis and suggest that antagonizing CXCR2 provides some therapeutic efficacy, possibly by impeding PMN recruitment into the mucosa.	dss	45-48	chemokine (C-X-C motif) receptor 2	Mus musculus	95-100
19231858-5	2009	Treatment with DSS resulted in weight loss, severe mucosal and submucosal inflammation, colonic crypt distortion, muscle wall thickening, down-regulation of mucin gene expression, and increased gastric permeability, but these symptoms were attenuated following supplementation with HEL and restored to basal levels observed in untreated control animals.	dss	15-18	LOC100508689	Homo sapiens	157-162
19240654-10	2009	bcl-2 (p = 0.021) and p63 (p = 0.025) were both found to be prognostic for improved disease-specific survival (DSS).	dss	111-114	BCL2 apoptosis regulator	Homo sapiens	0-5
19240654-10	2009	bcl-2 (p = 0.021) and p63 (p = 0.025) were both found to be prognostic for improved disease-specific survival (DSS).	dss	111-114	tumor protein p63	Homo sapiens	22-25
19240654-11	2009	Multivariate analysis (using age and biomarker expression) revealed that bcl-2 expression is prognostic for improved OS (p = 0.005) and DSS (p = 0.021).	dss	136-139	BCL2 apoptosis regulator	Homo sapiens	73-78
19240654-12	2009	CONCLUSIONS: Our results suggest that bcl-2 expression is prognostic for improved OS and DSS in NSCLC.	dss	89-92	BCL2 apoptosis regulator	Homo sapiens	38-43
19202076-1	2009	Here, we describe an N-ethyl-N-nitrosourea (ENU)-induced missense error in the membrane-bound transcription factor peptidase site 1 (S1P)-encoding gene (Mbtps1) that causes enhanced susceptibility to dextran sodium sulfate (DSS)-induced colitis.	dss	224-227	membrane-bound transcription factor peptidase, site 1	Mus musculus	133-136
19240720-1	2009	The aim of the study is to assess the value of carbonic anhydrase isozyme IX (CA IX) expression as a predictor of disease-free survival (DFS) and disease-specific survival (DSS) in rectal cancer treated by preoperative radio- or chemoradiotherapy or surgery only.	dss	173-176	carbonic anhydrase 9	Homo sapiens	78-83
19240720-5	2009	In univariate survival analysis, intensity of CA IX expression was a predictor of DFS (P=0.003) and DSS (P=0.034), both being markedly longer in tumours with negative or weakly positive staining.	dss	100-103	carbonic anhydrase 9	Homo sapiens	46-51
19240720-7	2009	Carbonic anhydrase isozyme IX intensity was the only independent predictor of DSS, with HR=9.2 for dying of disease with moderate-intense CA IX expression as compared with CA IX-negative/weak cases.	dss	78-81	carbonic anhydrase 9	Homo sapiens	0-29
19240720-7	2009	Carbonic anhydrase isozyme IX intensity was the only independent predictor of DSS, with HR=9.2 for dying of disease with moderate-intense CA IX expression as compared with CA IX-negative/weak cases.	dss	78-81	carbonic anhydrase 9	Homo sapiens	138-143
19240720-7	2009	Carbonic anhydrase isozyme IX intensity was the only independent predictor of DSS, with HR=9.2 for dying of disease with moderate-intense CA IX expression as compared with CA IX-negative/weak cases.	dss	78-81	carbonic anhydrase 9	Homo sapiens	172-177
19240720-8	2009	Negative/weak CA IX staining intensity is an independent predictor of longer DFS and DSS in rectal cancer.	dss	85-88	carbonic anhydrase 9	Homo sapiens	14-19
19202076-1	2009	Here, we describe an N-ethyl-N-nitrosourea (ENU)-induced missense error in the membrane-bound transcription factor peptidase site 1 (S1P)-encoding gene (Mbtps1) that causes enhanced susceptibility to dextran sodium sulfate (DSS)-induced colitis.	dss	224-227	membrane-bound transcription factor peptidase, site 1	Mus musculus	153-159
19202076-3	2009	Because S1P has a nonredundant function in the ATF6-dependent unfolded protein response (UPR), woodrat mice show diminished levels of major endoplasmic reticulum chaperones GRP78 (BiP) and GRP94 in the colon upon DSS administration.	dss	213-216	membrane-bound transcription factor peptidase, site 1	Mus musculus	8-11
18973187-4	2009	Necl-5-deficient mice were generated and treated with dimethylhydrazine (DMH) and/or dextran sodium sulphate (DSS) to induce colitis and its associated neoplasias.	dss	110-113	poliovirus receptor	Mus musculus	0-6
19147805-1	2009	Recent findings indicate that dextran sodium sulfate (DSS)-induced colitis is associated with a prothrombogenic phenotype, with P-selectin playing a major role in platelet recruitment.	dss	54-57	selectin P	Rattus norvegicus	128-138
19147805-8	2009	Disease activity index increased, as did the expression of P-selectin in the entire colon after DSS treatment, but both were reduced to control levels with L. reuteri pretreatment.	dss	96-99	selectin P	Rattus norvegicus	59-69
19232107-10	2009	The TNF-alpha response in the colon and serum of the DSS challenged and 2% WB fed mice was higher than controls.	dss	53-56	tumor necrosis factor	Mus musculus	4-13
19232107-12	2009	The in vivo effects of edible mushrooms required a challenge with DSS to detect small changes in TNF-alpha and transient protection from colonic injury.	dss	66-69	tumor necrosis factor	Mus musculus	97-106
19201890-6	2009	Following exposure to the oral innate trigger dextran sodium sulfate (DSS), a nonredundant proinflammatory role for Relm-alpha was uncovered as Retnla(-/-) mice were markedly protected from DSS-induced disease activity and histopathological features.	dss	70-73	resistin like alpha	Mus musculus	116-126
19201890-8	2009	Consistently, DSS-treated Retnla(-/-) mice displayed substantially decreased eosinophil accumulation and decreased phosphorylation of NF-kappaB, ERK1/2, and p38 in macrophages and eosinophils.	dss	14-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	134-143
19201890-8	2009	Consistently, DSS-treated Retnla(-/-) mice displayed substantially decreased eosinophil accumulation and decreased phosphorylation of NF-kappaB, ERK1/2, and p38 in macrophages and eosinophils.	dss	14-17	mitogen-activated protein kinase 3	Mus musculus	145-151
19201890-8	2009	Consistently, DSS-treated Retnla(-/-) mice displayed substantially decreased eosinophil accumulation and decreased phosphorylation of NF-kappaB, ERK1/2, and p38 in macrophages and eosinophils.	dss	14-17	mitogen-activated protein kinase 14	Mus musculus	157-160
19201890-9	2009	Following DSS exposure, serum level of Relm-alpha was up-regulated, and DSS-treated Retnla(-/-) mice were markedly protected from hyperglycemia induced by glucose injection independent of changes in insulin levels.	dss	10-13	resistin like alpha	Mus musculus	39-49
19074640-7	2009	alpha,beta-Methylene ADP (100 microM), an inhibitor of CD39, restored ATP-induced vasoconstriction in arterioles from mice with DSS-induced colitis.	dss	128-131	ectonucleoside triphosphate diphosphohydrolase 1	Mus musculus	55-59
19171847-9	2009	Our data demonstrate that MMP-2 and MMP-9 activities were highly upregulated in wild-type (WT) mice treated with DSS, S.T., or TNBS whereas dKO mice were resistant to the development of colitis.	dss	113-116	matrix metallopeptidase 2	Mus musculus	26-31
19171847-9	2009	Our data demonstrate that MMP-2 and MMP-9 activities were highly upregulated in wild-type (WT) mice treated with DSS, S.T., or TNBS whereas dKO mice were resistant to the development of colitis.	dss	113-116	matrix metallopeptidase 9	Mus musculus	36-41
18942765-6	2009	Importantly, similar downregulation of NHE1,3, beta-ENaC, and NHERF1,2 was also observed in the mouse colon (but not ileum) of DSS- and TNBS-induced colitis.	dss	127-130	solute carrier family 9 (sodium/hydrogen exchanger), member 1	Mus musculus	39-45
18942765-6	2009	Importantly, similar downregulation of NHE1,3, beta-ENaC, and NHERF1,2 was also observed in the mouse colon (but not ileum) of DSS- and TNBS-induced colitis.	dss	127-130	sodium channel, nonvoltage-gated 1 beta	Mus musculus	47-56
18942765-6	2009	Importantly, similar downregulation of NHE1,3, beta-ENaC, and NHERF1,2 was also observed in the mouse colon (but not ileum) of DSS- and TNBS-induced colitis.	dss	127-130	solute carrier family 9 (sodium/hydrogen exchanger), member 3 regulator 1	Mus musculus	62-68
19148529-8	2009	The promoter hypermethylation of TIMP3 and CDH1 was significantly related with better LRC (p=0.009 and p=0.02, respectively), OS (p=0.005 and p=0.002, respectively), DFS (p=0.02 and p=0.004, respectively) and DSS (p=0.12 and p=0.007, respectively).	dss	209-212	TIMP metallopeptidase inhibitor 3	Homo sapiens	33-38
19148529-8	2009	The promoter hypermethylation of TIMP3 and CDH1 was significantly related with better LRC (p=0.009 and p=0.02, respectively), OS (p=0.005 and p=0.002, respectively), DFS (p=0.02 and p=0.004, respectively) and DSS (p=0.12 and p=0.007, respectively).	dss	209-212	cadherin 1	Homo sapiens	43-47
19778264-7	2009	Treatment by DSS increased bowel LP, NO, and TNF-alpha while decreasing TAC, SOD, CAT, and TTM.	dss	13-16	tumor necrosis factor	Mus musculus	45-54
19778264-7	2009	Treatment by DSS increased bowel LP, NO, and TNF-alpha while decreasing TAC, SOD, CAT, and TTM.	dss	13-16	catalase	Mus musculus	82-85
19095961-5	2009	Mgl1(-/-) mice showed significantly more severe inflammation than wild-type mice after administration of DSS.	dss	105-108	C-type lectin domain family 10, member A	Mus musculus	0-4
19095961-7	2009	These cells in Mgl1(-/-) mice produced a lower level of IL-10 mRNA compared with wild-type mice after the administration of DSS for 2 days.	dss	124-127	C-type lectin domain family 10, member A	Mus musculus	15-19
19095961-7	2009	These cells in Mgl1(-/-) mice produced a lower level of IL-10 mRNA compared with wild-type mice after the administration of DSS for 2 days.	dss	124-127	interleukin 10	Mus musculus	56-61
18973187-7	2009	Total ulcer index and inflammatory cell infiltration were significantly lower in Necl-5(-/-) mice than in WT mice with DSS alone or DMH/DSS treatment.	dss	136-139	poliovirus receptor	Mus musculus	81-87
18973187-9	2009	The total Ki-67 labelling index in non-neoplastic colon epithelium was significantly higher in WT (45.9 +/- 0.94) than in Necl-5(+/-) (34.3 +/- 1.40) or Necl-5(-/-) (27.7 +/- 1.15) mice with DMH/DSS treatment (p &lt; 0.001).	dss	195-198	antigen identified by monoclonal antibody Ki 67	Mus musculus	10-15
18198984-6	2009	We observed that though DSS-treated Bacteroides ovatus-colonized SCID mice showed minor morphological changes in colon tissue, jejunal brush-border enzyme activities such as gamma-glutamyltranspeptidase, lactase and alkaline phosphatase were significantly reduced in comparison with DSS-untreated Bacteroides ovatus-colonized mice.	dss	24-27	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	65-69
19208060-8	2009	RESULTS: MS1 found the 95% limits of agreement (LOA) between SDSS and DSS to be -1.1 to 1.7 weeks.	dss	62-65	MS	Homo sapiens	9-12
18620902-8	2009	Univariate analysis showed that HIF-1alpha and EPOR expression were significantly related to DSS.	dss	93-96	hypoxia inducible factor 1 subunit alpha	Homo sapiens	32-42
18620902-8	2009	Univariate analysis showed that HIF-1alpha and EPOR expression were significantly related to DSS.	dss	93-96	erythropoietin receptor	Homo sapiens	47-51
18620902-9	2009	Multivariate analysis showed that EPOR expression was an independent predictor of DSS (P=0.030).	dss	82-85	erythropoietin receptor	Homo sapiens	34-38
18620902-10	2009	EPOR expression may be an independent predictor for DSS in patients with T2-staged SCC of the oral tongue.	dss	52-55	erythropoietin receptor	Homo sapiens	0-4
18198984-6	2009	We observed that though DSS-treated Bacteroides ovatus-colonized SCID mice showed minor morphological changes in colon tissue, jejunal brush-border enzyme activities such as gamma-glutamyltranspeptidase, lactase and alkaline phosphatase were significantly reduced in comparison with DSS-untreated Bacteroides ovatus-colonized mice.	dss	24-27	lactase	Mus musculus	204-211
18198984-6	2009	We observed that though DSS-treated Bacteroides ovatus-colonized SCID mice showed minor morphological changes in colon tissue, jejunal brush-border enzyme activities such as gamma-glutamyltranspeptidase, lactase and alkaline phosphatase were significantly reduced in comparison with DSS-untreated Bacteroides ovatus-colonized mice.	dss	283-286	protein kinase, DNA activated, catalytic polypeptide	Mus musculus	65-69
18854838-5	2008	In univariate analyses, high tumour epithelial cell expressions of NF-kappaB p105 (P=0.02) and E-cadherin (P=0.03) were positive prognostic indicators for disease-specific survival (DSS), whereas high tumour epithelial cell expression of vimentin (P=0.001) was a negative prognostic indicator.	dss	182-185	cadherin 1	Homo sapiens	95-105
19891583-11	2009	The immunofluorescence signals of occludin were disrupted and irregularly distributed in DSS-induced colitis, while the signals appeared as a typical reticular pattern but with reduced intensity by the administration of mesalazine, without any reduction in the protein content.	dss	89-92	occludin	Rattus norvegicus	34-42
19891583-14	2009	These findings suggest that the recovery of mucosal impairment due to treatment with mesalazine may be associated with the protection of the tight junction protein occludin in DSS-induced colitis.	dss	176-179	occludin	Rattus norvegicus	164-172
18796297-0	2008	Involvement of IL-17A in the pathogenesis of DSS-induced colitis in mice.	dss	45-48	interleukin 17A	Mus musculus	15-21
18796297-3	2008	Although the mortality rate of WT mice reached approximately 60%, more than 90% of the IL-17A KO mice survived the DSS treatment.	dss	115-118	interleukin 17A	Mus musculus	87-93
18796297-6	2008	The present results show that IL-17A plays a pivotal role in the pathogenesis of DSS-induced colitis, while MCP-1 and G-CSF may be crucially involved in the IL-17A-induced inflammation.	dss	81-84	interleukin 17A	Mus musculus	30-36
19084112-4	2008	OBJECTIVE: We sough to determine the role of Relm-alpha in dextran sodium sulfate (DSS)-induced colonic injury.	dss	83-86	resistin like alpha	Mus musculus	45-55
19084112-5	2008	METHODS: The cellular source of Relm-alpha was determined after oral DSS-induced colitis.	dss	69-72	resistin like alpha	Mus musculus	32-42
19084112-9	2008	RESULTS: After innate intestinal stimulation with DSS, Relm-alpha was highly expressed by eosinophils and epithelial cells.	dss	50-53	resistin like alpha	Mus musculus	55-65
19084112-10	2008	Retnla gene-targeted mice were protected from DSS-induced colitis (eg, decreased diarrhea, rectal bleeding, colon shortening, disease score, and histopathologic changes).	dss	46-49	resistin like alpha	Mus musculus	0-6
19084112-12	2008	Consistent with these finding, colon cultures of DSS-treated Retnla(-/-) mice produced decreased IL-6 and increased IL-10 ex vivo.	dss	49-52	resistin like alpha	Mus musculus	61-67
19084112-12	2008	Consistent with these finding, colon cultures of DSS-treated Retnla(-/-) mice produced decreased IL-6 and increased IL-10 ex vivo.	dss	49-52	interleukin 6	Mus musculus	97-101
19084112-12	2008	Consistent with these finding, colon cultures of DSS-treated Retnla(-/-) mice produced decreased IL-6 and increased IL-10 ex vivo.	dss	49-52	interleukin 10	Mus musculus	116-121
18981162-6	2008	Using the dextran sodium sulfate (DSS)-induced intestinal epithelial injury model, we show that DSS treatment of mice strongly induced colonic eotaxin-1 and eotaxin-2 expression and eosinophil levels.	dss	34-37	C-C motif chemokine ligand 11	Homo sapiens	143-152
18981162-6	2008	Using the dextran sodium sulfate (DSS)-induced intestinal epithelial injury model, we show that DSS treatment of mice strongly induced colonic eotaxin-1 and eotaxin-2 expression and eosinophil levels.	dss	34-37	chemokine (C-C motif) ligand 24	Mus musculus	157-166
18981162-6	2008	Using the dextran sodium sulfate (DSS)-induced intestinal epithelial injury model, we show that DSS treatment of mice strongly induced colonic eotaxin-1 and eotaxin-2 expression and eosinophil levels.	dss	96-99	C-C motif chemokine ligand 11	Homo sapiens	143-152
18981162-6	2008	Using the dextran sodium sulfate (DSS)-induced intestinal epithelial injury model, we show that DSS treatment of mice strongly induced colonic eotaxin-1 and eotaxin-2 expression and eosinophil levels.	dss	96-99	chemokine (C-C motif) ligand 24	Mus musculus	157-166
18981162-8	2008	DSS treatment of eotaxin-2(-/-) and eotaxin-1/2(-/-) mice demonstrated that eosinophil recruitment was dependent on eotaxin-1.	dss	0-3	chemokine (C-C motif) ligand 24	Mus musculus	17-26
18981162-8	2008	DSS treatment of eotaxin-2(-/-) and eotaxin-1/2(-/-) mice demonstrated that eosinophil recruitment was dependent on eotaxin-1.	dss	0-3	chemokine (C-C motif) ligand 24	Mus musculus	36-47
18981162-8	2008	DSS treatment of eotaxin-2(-/-) and eotaxin-1/2(-/-) mice demonstrated that eosinophil recruitment was dependent on eotaxin-1.	dss	0-3	C-C motif chemokine ligand 11	Homo sapiens	36-45
18981162-9	2008	In situ and immunofluorescence analysis-identified eotaxin-1 expression was restricted to intestinal F4/80(+)CD11b(+) macrophages in DSS-induced epithelial injury and to CD68(+) intestinal macrophages and the basolateral compartment of intestinal epithelial cells in pediatric UC.	dss	133-136	C-C motif chemokine ligand 11	Homo sapiens	51-60
18981162-9	2008	In situ and immunofluorescence analysis-identified eotaxin-1 expression was restricted to intestinal F4/80(+)CD11b(+) macrophages in DSS-induced epithelial injury and to CD68(+) intestinal macrophages and the basolateral compartment of intestinal epithelial cells in pediatric UC.	dss	133-136	integrin alpha M	Mus musculus	109-114
18843117-13	2008	These results identify regulation of splicing by growth and splice factors as a key event in determining the relative pro-versus anti-angiogenic expression of VEGF isoforms, and suggest that p38 MAPK-Clk/sty kinases are responsible for the TGFbeta1-induced DSS selection, and identify SRp55 as a key regulatory splice factor.	dss	257-260	CDC like kinase 1	Homo sapiens	204-207
18772359-4	2008	The light/dye endothelial injury model was used to elicit thrombus formation in DSS colitic mice treated with either hirudin, heparin, or antithrombin III.	dss	80-83	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	138-154
18772359-8	2008	However, all three antithrombin agents largely prevented the DSS-induced reduction in the time to flow cessation following light/dye injury, with hirudin offering complete protection.	dss	61-64	serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1	Mus musculus	19-31
18843117-6	2008	IGF1, and TNFalpha treatment favoured PSS (increasing VEGFxxx) whereas TGFbeta1 favoured DSS, increasing VEGFxxxb levels.	dss	89-92	transforming growth factor beta 1	Homo sapiens	71-79
18378310-8	2008	Sixteen case studies were evaluated with the SRC-DSS.	dss	49-52	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	45-48
18843117-7	2008	TGFbeta1 induced DSS selection was prevented by inhibition of p38 MAPK and the Clk/sty (CDC-like kinase, CLK1) splicing factor kinase family, but not ERK1/2.	dss	17-20	transforming growth factor beta 1	Homo sapiens	0-8
18843117-7	2008	TGFbeta1 induced DSS selection was prevented by inhibition of p38 MAPK and the Clk/sty (CDC-like kinase, CLK1) splicing factor kinase family, but not ERK1/2.	dss	17-20	CDC like kinase 1	Homo sapiens	79-86
18843117-7	2008	TGFbeta1 induced DSS selection was prevented by inhibition of p38 MAPK and the Clk/sty (CDC-like kinase, CLK1) splicing factor kinase family, but not ERK1/2.	dss	17-20	CDC like kinase 1	Homo sapiens	105-109
18843117-10	2008	ASF/SF2, and SRp40 both favoured PSS, whereas SRp55 upregulated VEGFxxxb (DSS) isoforms relative to VEGFxxx.	dss	74-77	serine and arginine rich splicing factor 6	Homo sapiens	46-51
18843117-13	2008	These results identify regulation of splicing by growth and splice factors as a key event in determining the relative pro-versus anti-angiogenic expression of VEGF isoforms, and suggest that p38 MAPK-Clk/sty kinases are responsible for the TGFbeta1-induced DSS selection, and identify SRp55 as a key regulatory splice factor.	dss	257-260	vascular endothelial growth factor A	Homo sapiens	159-163
18843117-13	2008	These results identify regulation of splicing by growth and splice factors as a key event in determining the relative pro-versus anti-angiogenic expression of VEGF isoforms, and suggest that p38 MAPK-Clk/sty kinases are responsible for the TGFbeta1-induced DSS selection, and identify SRp55 as a key regulatory splice factor.	dss	257-260	CDC like kinase 1	Homo sapiens	200-203
18535110-7	2008	However, expression of CYP27b1 was increased in the proximal colon of DSS mice (4-fold compared with controls, P&lt;0.001).	dss	70-73	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	23-30
18535110-11	2008	Conversely, DSS-treated Cyp27b1-/-mice exhibited lower IL-10 in the proximal colon and toll-like receptors 2 and 4 in the distal colon.	dss	12-15	cytochrome P450, family 27, subfamily b, polypeptide 1	Mus musculus	24-31
18535110-11	2008	Conversely, DSS-treated Cyp27b1-/-mice exhibited lower IL-10 in the proximal colon and toll-like receptors 2 and 4 in the distal colon.	dss	12-15	interleukin 10	Mus musculus	55-60
18535110-11	2008	Conversely, DSS-treated Cyp27b1-/-mice exhibited lower IL-10 in the proximal colon and toll-like receptors 2 and 4 in the distal colon.	dss	12-15	toll-like receptor 2	Mus musculus	87-114
18536750-8	2008	KEY RESULTS: Mice fed ATL-801 along with DSS showed a significantly lower extent and severity of colitis than mice treated with DSS alone, as shown by reduced clinical symptoms, histological scores, IL-6 levels and proliferation indices.	dss	41-44	interleukin 6	Mus musculus	199-203
18514072-6	2008	RESULTS: The DSS-induced thrombosis response was greatly attenuated in transgenic mice over expressing the endothelial protein C receptor.	dss	13-16	protein C receptor, endothelial	Mus musculus	107-137
17990103-5	2008	The DSS rat shows an elevation in renal APA activity at the onset of hypertension suggesting a protective role against elevations in circulating AngII, followed by decreased APA activity with advancing hypertension.	dss	4-7	angiotensinogen	Rattus norvegicus	145-150
18727087-5	2008	In DSS-treated control mice the colon wall contrast agent extravasation rate constant, K(trans), and extravascular extracellular space volume fraction, v(e), values were measured for the first time and found to be 0.10 +/- 0.03 min(-1) and 0.23 +/- 0.09, respectively.	dss	3-6	APC, WNT signaling pathway regulator	Mus musculus	228-231
18727087-6	2008	In DSS-treated Min mice, polyp K(trans) values (0.09 +/- 0.04 min(-1)) were similar to those in the colon wall but the v(e) values were substantially lower (0.16 +/- 0.03), suggesting increased cellular density.	dss	3-6	APC, WNT signaling pathway regulator	Mus musculus	15-18
18727087-6	2008	In DSS-treated Min mice, polyp K(trans) values (0.09 +/- 0.04 min(-1)) were similar to those in the colon wall but the v(e) values were substantially lower (0.16 +/- 0.03), suggesting increased cellular density.	dss	3-6	APC, WNT signaling pathway regulator	Mus musculus	62-65
18695901-6	2008	Furthermore, CAIX expression significantly stratified the DSS of patients with high-stage (p=0.0001), high-grade (p=0.0392), low-grade (p=0.0273), metastasis (p=0.0034), no metastasis (p=0.0303) and ECOG-PS=0 (p=0.0003).	dss	58-61	carbonic anhydrase 9	Homo sapiens	13-17
18695901-8	2008	A multivariate Cox regression analysis showed that tumor stage (p=0.0054), metastasis (p=0.0193), ECOG-PS (p=0.0065) and CAIX expression (p=0.0001) were independent prognostic factors of DSS.	dss	187-190	carbonic anhydrase 9	Homo sapiens	121-125
18695901-13	2008	Independent expression of CAIX and a co-expression of CAIX-VEGF were found to be independent predictors of DSS.	dss	107-110	carbonic anhydrase 9	Homo sapiens	26-30
18695901-13	2008	Independent expression of CAIX and a co-expression of CAIX-VEGF were found to be independent predictors of DSS.	dss	107-110	carbonic anhydrase 9	Homo sapiens	54-58
18695901-13	2008	Independent expression of CAIX and a co-expression of CAIX-VEGF were found to be independent predictors of DSS.	dss	107-110	vascular endothelial growth factor A	Homo sapiens	59-63
18662832-3	2008	Less severe histological abnormalities and clinical scores were detected in dextran sulphate sodium (DSS)-induced colitis in IFN-gamma(-/-), compared to Wt, mice.	dss	101-104	interferon gamma	Mus musculus	125-134
18662832-4	2008	Disease severity was increased by restraint stress in DSS-treated IFN-gamma(-/-) and Wt mice, accompanied by suppressed colonic pro and anti inflammatory cytokine responses.	dss	54-57	interferon gamma	Mus musculus	66-75
18756598-7	2008	As to co-expression with another member of the adhesion complex (beta-catenin), high alpha-catenin/beta-catenin MI index was of marginal significance in predicting longer DSS (P = 0.063, log-rank).	dss	171-174	catenin beta 1	Homo sapiens	65-77
18756598-7	2008	As to co-expression with another member of the adhesion complex (beta-catenin), high alpha-catenin/beta-catenin MI index was of marginal significance in predicting longer DSS (P = 0.063, log-rank).	dss	171-174	catenin beta 1	Homo sapiens	99-111
18442038-8	2008	Moreover, inactivation of p19(ARF) exacerbated the ulceration of the colonic epithelium caused by dextran sodium sulfate (DSS).	dss	122-125	cyclin dependent kinase inhibitor 2D	Mus musculus	26-29
18442038-9	2008	These effects were similar to those observed in mice lacking myeloid translocation gene-related-1 (Mtgr1), and mice lacking both of these genes showed an even greater sensitivity to DSS.	dss	182-185	CBFA2/RUNX1 translocation partner 2	Mus musculus	99-104
18580492-8	2008	Multivariate Cox regression analysis showed that increasing RGS1 immunostaining had an independent impact on the relapse-free survival (P=0.0069) and DSS (P=0.0077) of this melanoma cohort.	dss	150-153	regulator of G protein signaling 1	Homo sapiens	60-64
18580492-9	2008	In the analysis of DSS, RGS1 expression level was the most powerful factor predicting DSS.	dss	19-22	regulator of G protein signaling 1	Homo sapiens	24-28
18580492-9	2008	In the analysis of DSS, RGS1 expression level was the most powerful factor predicting DSS.	dss	86-89	regulator of G protein signaling 1	Homo sapiens	24-28
18656634-10	2008	CONCLUSION: ACE-I/PEG is effective in preventing colonic fibrosis and pro-inflammatory cytokine expression in a DSS colitis model, most likely by down-regulating the TGF-beta signaling pathway.	dss	112-115	transforming growth factor, beta 1	Mus musculus	166-174
18598698-9	2008	TL1A, death receptor 3, interferon (IFN)-gamma, and interleukin (IL)-17 were increased significantly in GALT of DSS-treated mice.	dss	112-115	TNF superfamily member 15	Homo sapiens	0-4
18598698-9	2008	TL1A, death receptor 3, interferon (IFN)-gamma, and interleukin (IL)-17 were increased significantly in GALT of DSS-treated mice.	dss	112-115	interleukin 17A	Mus musculus	52-71
18656634-1	2008	BACKGROUND: We have previously shown that angiotensin converting enzyme-inhibitor (ACE-I) improved colonic inflammation and apoptosis in a dextran sodium sulfate (DSS)-induced colitis model.	dss	163-166	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	42-71
18579189-8	2008	Five-year actual DSS by pT stage was 100% for pTa and pTis, 95% for pT1, 70% for pT2, 54% for pT3, and 14% for pT4 tumors.	dss	17-20	zinc finger protein 77	Homo sapiens	68-71
18514073-8	2008	Deletion of JAM-A results in a dramatic increase in susceptibility to DSS colitis, as assessed by weight loss, disease activity index, histologic and endoscopic severity, and strikingly high mortality rates.	dss	70-73	F11 receptor	Mus musculus	12-17
17874182-5	2008	RESULTS: In univariate analysis, only STMN1 staining intensity strongly correlated with DFS (P = 0.014) and DSS (P = 0.002).	dss	108-111	stathmin 1	Homo sapiens	38-43
17874182-7	2008	STMN1 retained its prognostic value for DFS (P = 0.002) and DSS (&lt;0.001) in the multivariate model together with lymph node status.	dss	60-63	stathmin 1	Homo sapiens	0-5
18326560-8	2008	Following azoxymethane and dextran sodium sulfate (DSS) treatment, fewer total tumours were observed in the ILK knockout animals, which were mosaic with respect to ILK expression.	dss	51-54	integrin linked kinase	Mus musculus	108-111
18536734-5	2008	MPO activity, pro-inflammatory cytokines and COX-2 levels, NF-kappaB p65 nuclear translocation and inhibitory protein of nuclear factor-kappaB-alpha degradation levels were significantly increased in DSS-induced colitis tissues.	dss	200-203	myeloperoxidase	Mus musculus	0-3
18474878-5	2008	RESULTS: EGFR expression was inversely associated with response to induction chemotherapy (IC) (P = .01), chemotherapy/radiotherapy (CRT; P = .055), overall survival (OS; P = .001), and disease-specific survival (DSS; P = .002) and was directly associated with current smoking (P = .04), female sex (P = .053), and lower HPV titer (P = .03).	dss	213-216	epidermal growth factor receptor	Homo sapiens	9-13
18474878-6	2008	HPV titer was significantly associated with p16 expression (P &lt; .0001); p16 was significantly associated with response to IC (P = .008), CRT (P = .009), OS (P = .001), and DSS (P = .003).	dss	175-178	cyclin dependent kinase inhibitor 2A	Homo sapiens	75-78
18474878-7	2008	As combined markers, lower HPV titer and high EGFR expression were associated with worse OS (rho(EGFR) = 0.008; rho(HPV) = 0.03) and DSS (rho(EGFR) = 0.01; rho(HPV) = 0.016).	dss	133-136	epidermal growth factor receptor	Homo sapiens	46-50
18474878-9	2008	The combination of low p53 and high Bcl-xL expression was associated with poor OS (P = .005) and DSS (P = .002).	dss	97-100	tumor protein p53	Homo sapiens	23-26
18474878-9	2008	The combination of low p53 and high Bcl-xL expression was associated with poor OS (P = .005) and DSS (P = .002).	dss	97-100	BCL2 like 1	Homo sapiens	36-42
18536734-5	2008	MPO activity, pro-inflammatory cytokines and COX-2 levels, NF-kappaB p65 nuclear translocation and inhibitory protein of nuclear factor-kappaB-alpha degradation levels were significantly increased in DSS-induced colitis tissues.	dss	200-203	cytochrome c oxidase II, mitochondrial	Mus musculus	45-50
18536734-5	2008	MPO activity, pro-inflammatory cytokines and COX-2 levels, NF-kappaB p65 nuclear translocation and inhibitory protein of nuclear factor-kappaB-alpha degradation levels were significantly increased in DSS-induced colitis tissues.	dss	200-203	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	69-72
18713728-0	2008	Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis.	dss	118-121	chemokine (C-X-C motif) receptor 2	Mus musculus	22-27
18239938-8	2008	Abnormal Dicer expression correlates with high-grade and advanced stage, acting as a univariate predictor of poor disease-specific survival (DSS) in MEC.	dss	141-144	dicer 1, ribonuclease III	Homo sapiens	9-14
18713728-0	2008	Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis.	dss	118-121	chemokine (C-X-C motif) ligand 1	Mus musculus	36-41
18713728-0	2008	Mice deficient in the CXCR2 ligand, CXCL1 (KC/GRO-alpha), exhibit increased susceptibility to dextran sodium sulfate (DSS)-induced colitis.	dss	118-121	chemokine (C-X-C motif) ligand 1	Mus musculus	43-55
18713728-1	2008	The role of TLRs and MyD88 in the maintenance of gut integrity in response to dextran sodium sulfate (DSS)-induced colitis was demonstrated recently and led to the conclusion that the innate immune response to luminal commensal flora provides necessary signals that facilitate epithelial repair and permits a return to homeostasis after colonic injury.	dss	102-105	myeloid differentiation primary response gene 88	Mus musculus	21-26
18713728-2	2008	In this report, we demonstrate that a deficit in a single neutrophil chemokine, CXCL1/KC, also results in a greatly exaggerated response to DSS.	dss	140-143	chemokine (C-X-C motif) ligand 1	Mus musculus	80-85
18223102-9	2008	TFF3 was substantially reduced in the cecum and increased in the colon of aged but not younger TLR2(-/-) mice following DSS treatment.	dss	120-123	trefoil factor 3, intestinal	Mus musculus	0-4
18495601-1	2008	OBJECTIVE: To investigate the changes in the activity of nuclear factor-kappaB (NF-kappa B) in mice with dextran sulphate sodium (DSS)-induced rat colitis and its modulalorg effect on intercellular adhesion molecule-1 (ICAM-1) expression.	dss	130-133	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-78
18495601-1	2008	OBJECTIVE: To investigate the changes in the activity of nuclear factor-kappaB (NF-kappa B) in mice with dextran sulphate sodium (DSS)-induced rat colitis and its modulalorg effect on intercellular adhesion molecule-1 (ICAM-1) expression.	dss	130-133	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-90
18495601-1	2008	OBJECTIVE: To investigate the changes in the activity of nuclear factor-kappaB (NF-kappa B) in mice with dextran sulphate sodium (DSS)-induced rat colitis and its modulalorg effect on intercellular adhesion molecule-1 (ICAM-1) expression.	dss	130-133	intercellular adhesion molecule 1	Rattus norvegicus	184-217
18495601-1	2008	OBJECTIVE: To investigate the changes in the activity of nuclear factor-kappaB (NF-kappa B) in mice with dextran sulphate sodium (DSS)-induced rat colitis and its modulalorg effect on intercellular adhesion molecule-1 (ICAM-1) expression.	dss	130-133	intercellular adhesion molecule 1	Rattus norvegicus	219-225
18495601-7	2008	RESULTS: The DNA-binding activity of NF-kappa B was significantly increased in DSS group as compared with NS group.	dss	79-82	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-47
18495601-10	2008	CONCLUSION: NF-kappa B activation is an important event in the development of DSS-induced colitis in that activated NF-kappa B upregulates ICAM-1 expression during colonic inflammation.	dss	78-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	12-22
18495601-10	2008	CONCLUSION: NF-kappa B activation is an important event in the development of DSS-induced colitis in that activated NF-kappa B upregulates ICAM-1 expression during colonic inflammation.	dss	78-81	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	116-126
18495601-10	2008	CONCLUSION: NF-kappa B activation is an important event in the development of DSS-induced colitis in that activated NF-kappa B upregulates ICAM-1 expression during colonic inflammation.	dss	78-81	intercellular adhesion molecule 1	Mus musculus	139-145
18092346-2	2008	The anti-inflammatory effects of melanocortin peptides such as alpha-melanocyte-stimulating hormone (alpha-MSH) have been described recently in, for example, dextran sodium sulfate (DSS) colitis in mice.	dss	182-185	pro-opiomelanocortin-alpha	Mus musculus	63-99
18191038-0	2008	4-Hydroxydocosahexaenoic acid, a potent peroxisome proliferator-activated receptor gamma agonist alleviates the symptoms of DSS-induced colitis.	dss	124-127	peroxisome proliferator activated receptor gamma	Mus musculus	40-88
18092346-2	2008	The anti-inflammatory effects of melanocortin peptides such as alpha-melanocyte-stimulating hormone (alpha-MSH) have been described recently in, for example, dextran sodium sulfate (DSS) colitis in mice.	dss	182-185	pro-opiomelanocortin-alpha	Mus musculus	101-110
18300860-5	2008	RESULTS: DSS rats on a high salt diet developed hypertension, LVH, proteinuria, increased production of aortic O2(-) (106%), impaired EDR, and aortic upregulation of AT1 receptor (198%), LOX-1 (135%), and MCP-1 (145%).	dss	9-12	oxidized low density lipoprotein receptor 1	Rattus norvegicus	187-192
18300860-5	2008	RESULTS: DSS rats on a high salt diet developed hypertension, LVH, proteinuria, increased production of aortic O2(-) (106%), impaired EDR, and aortic upregulation of AT1 receptor (198%), LOX-1 (135%), and MCP-1 (145%).	dss	9-12	C-C motif chemokine ligand 2	Rattus norvegicus	205-210
18023891-10	2008	Valsartan reduced the protein levels of TGFbeta (p&lt;0.05), and IL-18 in the TNBS model, and led to over expression of IL-10 mRNA in the DSS model.	dss	138-141	interleukin 10	Rattus norvegicus	120-125
18631401-9	2008	Regardless of PR status, the Ox-E/ER index associated with reduced DSS (n = 201; univariate Cox, P = 0.078) and, using the optimized cut-point, separated ER-positive cases into two significantly different DSS groups (log rank, P = 0.0009).	dss	67-70	estrogen receptor 1	Homo sapiens	34-36
18242213-7	2008	RESULTS: Following DSS administration, mice lacking both RAG and TNFR1 exhibited a high mortality (&gt;80%) rate with an impaired CEC regeneration compared with RAG KO and RAG x TNFR2 double KO (DKO) mice.	dss	19-22	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	65-70
18024785-10	2008	Furthermore, NK3201 significantly attenuated not only chymase activity but also MMP-9 activity in DSS-treated mice.	dss	98-101	matrix metallopeptidase 9	Mus musculus	80-85
18654953-3	2008	Myeloperoxidase (MPO) activity in colonic tissue also increased with DSS administration, suggesting the development of inflammation.	dss	69-72	myeloperoxidase	Mus musculus	0-15
18023025-8	2008	Kaplan-Meier analysis demonstrated an association between osteopontin expression and reduced RFS (P &lt; .03) and DSS (P = .05).	dss	114-117	secreted phosphoprotein 1	Homo sapiens	58-69
18023025-9	2008	Multivariate Cox regression analysis demonstrated that high osteopontin immunostaining had an independent impact on the DSS of this melanoma cohort (P = .049).	dss	120-123	secreted phosphoprotein 1	Homo sapiens	60-71
18654953-3	2008	Myeloperoxidase (MPO) activity in colonic tissue also increased with DSS administration, suggesting the development of inflammation.	dss	69-72	myeloperoxidase	Mus musculus	17-20
18654953-4	2008	Because simultaneous administration of SM with DSS prevented the MPO activity increase, we concluded that SM could suppress the development of inflammation.	dss	47-50	myeloperoxidase	Mus musculus	65-68
17595234-6	2007	RESULTS: Heterozygous Cdx2(+/-) mice, but not Cdx1(-/-) mice, were hypersensitive to DSS-induced acute inflammation as all these mice showed blood in the stools at day 1 of DSS treatment.	dss	85-88	caudal type homeobox 2	Mus musculus	22-26
18005362-7	2008	The levels of myeloperoxidase activity and interleukin (IL)-12p40 were attenuated in pretreated TLR-4(lps-/lps-) mice after DSS administration.	dss	124-127	toll-like receptor 4	Mus musculus	96-101
17948916-9	2007	On multivariate analysis, predictors of disease-specific survival (DSS) included an elevated alpha-fetoprotein (AFP) level before PC-RPLND (P = .003) and postoperative disease recurrence (P = .02).	dss	67-70	alpha fetoprotein	Homo sapiens	93-110
17948916-9	2007	On multivariate analysis, predictors of disease-specific survival (DSS) included an elevated alpha-fetoprotein (AFP) level before PC-RPLND (P = .003) and postoperative disease recurrence (P = .02).	dss	67-70	alpha fetoprotein	Homo sapiens	112-115
17948916-10	2007	A serum AFP level &gt;5.3 ng/mL before PC-RPLND was found to be predictive of a poorer DSS (P = .0007).	dss	87-90	alpha fetoprotein	Homo sapiens	8-11
17909917-15	2007	Factors associated with decreased DSS included positive nodes at resection, pT3 tumor or greater, high grade, perineural or vascular invasion, and &lt;50% response.	dss	34-37	zinc finger protein 135	Homo sapiens	76-79
17595234-6	2007	RESULTS: Heterozygous Cdx2(+/-) mice, but not Cdx1(-/-) mice, were hypersensitive to DSS-induced acute inflammation as all these mice showed blood in the stools at day 1 of DSS treatment.	dss	173-176	caudal type homeobox 2	Mus musculus	22-26
17595234-8	2007	In Cdx2(+/-) mice, the colonic epithelium was repaired during the week after the end of DSS treatment, whereas two weeks were required for wild type animals.	dss	88-91	caudal type homeobox 2	Mus musculus	3-7
17404849-5	2007	PPARbeta/delta-null mice exhibited increased sensitivity to DSS-induced colitis, as shown by marked differences in body weight loss, colon length, colonic morphology, myeloperoxidase activity and increased expression of mRNAs encoding the inflammatory markers interferon gamma, tumor necrosis factor-alpha, and interleukin-6 compared to similarly treated wild-type mice.	dss	60-63	peroxisome proliferator activator receptor delta	Mus musculus	0-8
17884975-8	2007	DSS colitis was also associated with an increased expression of PSGL-1 in the colonic vasculature.	dss	0-3	selectin, platelet (p-selectin) ligand	Mus musculus	64-70
17221157-10	2007	Our study suggests that the type of TP53 mutation, especially missense mutation, is a strong prognostic indicator for DFS and DSS in node-negative breast cancer, particularly in combination with ERBB2 amplification.	dss	126-129	tumor protein p53	Homo sapiens	36-40
17768420-4	2007	This is consistent with higher levels of monocyte chemotactic protein-1, interleukin (IL)-6 and granulocyte monocyte colony-stimulating factor (GM-CSF) in the inflamed colon from the TNF-alpha(-/-) mice, compared to the Wt mice, following dextran sulphate sodium (DSS) challenge.	dss	264-267	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	144-150
17768420-6	2007	The expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) was upregulated in the colon of Wt and TNF-alpha(-/-) mice following DSS challenge.	dss	141-144	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	18-60
17768420-6	2007	The expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) was upregulated in the colon of Wt and TNF-alpha(-/-) mice following DSS challenge.	dss	141-144	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	62-70
17768420-6	2007	The expression of mucosal addressin cell adhesion molecule 1 (MAdCAM-1) was upregulated in the colon of Wt and TNF-alpha(-/-) mice following DSS challenge.	dss	141-144	tumor necrosis factor	Mus musculus	111-120
17768420-9	2007	Furthermore, there was a reduction of both immunoglobulin A (IgA) and IgG in the gut from TNF-alpha(-/-) mice following DSS challenge.	dss	120-123	immunoglobulin heavy constant alpha	Mus musculus	43-73
17768420-9	2007	Furthermore, there was a reduction of both immunoglobulin A (IgA) and IgG in the gut from TNF-alpha(-/-) mice following DSS challenge.	dss	120-123	tumor necrosis factor	Mus musculus	90-99
17768420-10	2007	These data indicate that TNF-alpha deficiency alters homoeostasis of the colonic chemokine/cytokine environment and humoral immune response, resulting in an exacerbation of acute DSS-induced colitis in TNF-alpha(-/-) mice.	dss	179-182	tumor necrosis factor	Mus musculus	25-34
17557291-8	2007	Seven of 9 (77.8%) colonic adenocarcinomas developed in mice treated with APNH (10 mg/kg body weight) and DSS had beta-catenin gene mutations at codons 32 and 37, being predominantly transversion.	dss	106-109	catenin (cadherin associated protein), beta 1	Mus musculus	114-126
17786954-6	2007	On multivariate analysis, an elevated serum LDH level and low serum albumin at the time of SCC diagnosis was found to be predictive of inferior progression-free survival (P = .02 and P = .008, respectively) and inferior disease-specific survival (DSS) (P = .02 and P = .01, respectively).	dss	247-250	serpin family B member 3	Homo sapiens	91-94
17510083-10	2007	These findings indicate that inflammation-associated regenerative mucosa with Paneth cell metaplasia and alteration in the APC/beta-catenin/Tcf signal transduction pathway are possibly involved in the acceleration of colorectal carcinogenesis in this DMH-DSS rat model.	dss	255-258	catenin beta 1	Rattus norvegicus	127-139
18049032-3	2007	In the current study, we therefore examined albuminuria and the expressions of NADPH oxidase and monocyte chemoattractant protein-1 (MCP-1) in the renal tubular cells in hypertensive DSS rats, as well as the effects of the antioxidant N-acetylcysteine (NAC) on each of these parameters.	dss	183-186	chemokine (C-C motif) ligand 2	Mus musculus	133-138
18049032-7	2007	The current results suggest that albuminuria caused expression of NADPH oxidase and MCP-1 in the dilated renal tubules, resulting in interstitial inflammation and migration of mononuclear cells in DSS rats, because blockade of albuminuria by NAC counteracted the p47phox and MCP-1 expression.	dss	197-200	C-C motif chemokine ligand 2	Rattus norvegicus	84-89
18210234-3	2007	In this study, a novel technique utilizing antibody conjugated quantum dot nanoparticles was developed to detect Myeloperoxidase, Interleukin-1alpha (IL-1alpha) and Tumor Necrosis Factor-alpha (TNF-alpha) in vivo in the dextran sodium sulfate (DSS) model of experimental colitis.	dss	244-247	myeloperoxidase	Mus musculus	113-128
18210234-3	2007	In this study, a novel technique utilizing antibody conjugated quantum dot nanoparticles was developed to detect Myeloperoxidase, Interleukin-1alpha (IL-1alpha) and Tumor Necrosis Factor-alpha (TNF-alpha) in vivo in the dextran sodium sulfate (DSS) model of experimental colitis.	dss	244-247	tumor necrosis factor	Mus musculus	194-203
18006765-9	2007	In multivariate analyses, high expression in tumor cells of VEGFR-3 (P = 0.007) was an independent negative prognostic factor for DSS, whereas in stromal cells, high VEGF-C (P = 0.004) expression had an independent positive survival impact.	dss	130-133	fms related receptor tyrosine kinase 4	Homo sapiens	60-67
17404849-5	2007	PPARbeta/delta-null mice exhibited increased sensitivity to DSS-induced colitis, as shown by marked differences in body weight loss, colon length, colonic morphology, myeloperoxidase activity and increased expression of mRNAs encoding the inflammatory markers interferon gamma, tumor necrosis factor-alpha, and interleukin-6 compared to similarly treated wild-type mice.	dss	60-63	interferon gamma	Mus musculus	260-305
17404849-5	2007	PPARbeta/delta-null mice exhibited increased sensitivity to DSS-induced colitis, as shown by marked differences in body weight loss, colon length, colonic morphology, myeloperoxidase activity and increased expression of mRNAs encoding the inflammatory markers interferon gamma, tumor necrosis factor-alpha, and interleukin-6 compared to similarly treated wild-type mice.	dss	60-63	interleukin 6	Mus musculus	311-324
17404849-7	2007	These studies demonstrate that PPARbeta/delta expression in the colonic epithelium inhibits inflammation and protects against DSS-induced colitis through a ligand-independent mechanism.	dss	126-129	peroxisome proliferator activator receptor delta	Mus musculus	31-39
17317789-10	2007	Both CD40- and CD40L-deficient mice were protected from DSS-induced colitis and displayed a significant impairment of gut inflammation-driven angiogenesis, as assessed by microvascular density.	dss	56-59	CD40 antigen	Mus musculus	5-9
17317789-10	2007	Both CD40- and CD40L-deficient mice were protected from DSS-induced colitis and displayed a significant impairment of gut inflammation-driven angiogenesis, as assessed by microvascular density.	dss	56-59	CD40 ligand	Mus musculus	15-20
17510197-13	2007	PECAM-1 plays an important role in transendothelial leukocyte migration in DSS colitis.	dss	75-78	platelet/endothelial cell adhesion molecule 1	Mus musculus	0-7
17417780-9	2007	In addition, the treatment with ONO-1714 significantly lowered the serum triglyceride levels and mRNA expression levels of COX-2, TNFalpha and IL-1beta of colonic mucosa in the DSS-treated Apc(Min/+) mice.	dss	177-180	cytochrome c oxidase II, mitochondrial	Mus musculus	123-128
17417780-9	2007	In addition, the treatment with ONO-1714 significantly lowered the serum triglyceride levels and mRNA expression levels of COX-2, TNFalpha and IL-1beta of colonic mucosa in the DSS-treated Apc(Min/+) mice.	dss	177-180	tumor necrosis factor	Mus musculus	130-138
17417780-9	2007	In addition, the treatment with ONO-1714 significantly lowered the serum triglyceride levels and mRNA expression levels of COX-2, TNFalpha and IL-1beta of colonic mucosa in the DSS-treated Apc(Min/+) mice.	dss	177-180	interleukin 1 beta	Mus musculus	143-151
17372819-0	2007	Regulation of the oligopeptide transporter, PEPT-1, in DSS-induced rat colitis.	dss	55-58	solute carrier family 15 member 1	Rattus norvegicus	44-50
17611628-5	2007	Interestingly, NF-kappaB(EGFP) transgenic mice exposed to luteolin showed worse DSS-induced colitis (weight loss, histological scores) compared to control-fed mice, whereas spontaneous colitis in IL-10(-/-);NF-kappaB(EGFP) mice was significantly attenuated.	dss	80-83	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	15-24
17611628-8	2007	Caspase 3 activation was significantly enhanced whereas COX-2 gene expression was reduced in luteolin-fed, DSS-exposed NF-kappaB(EGFP) transgenic mice as assessed by Western blot and immunohistochemical analysis.	dss	107-110	caspase 3	Mus musculus	0-9
17611628-8	2007	Caspase 3 activation was significantly enhanced whereas COX-2 gene expression was reduced in luteolin-fed, DSS-exposed NF-kappaB(EGFP) transgenic mice as assessed by Western blot and immunohistochemical analysis.	dss	107-110	cytochrome c oxidase II, mitochondrial	Mus musculus	56-61
17611628-8	2007	Caspase 3 activation was significantly enhanced whereas COX-2 gene expression was reduced in luteolin-fed, DSS-exposed NF-kappaB(EGFP) transgenic mice as assessed by Western blot and immunohistochemical analysis.	dss	107-110	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	119-128
17653282-6	2007	Concentrations of Bacteroides/ Prevotella spp., and enterococci did not increase during colitis, but their numbers were significantly reduced in the colon of DSS-treated TLR2/4(-/-) animals (P&lt;0.01).	dss	158-161	toll-like receptor 2	Mus musculus	170-176
17592298-8	2007	Smaller size (HR = 0.3 per 5-cm decrease, P &lt; 0.0001) and treatment with IF (HR = 0.3 compared with NoC, P = 0.007) were independently associated with an improved DSS.	dss	166-169	nocturnin	Homo sapiens	103-106
17616656-2	2007	Here, we report that Tir8-deficient mice exhibited a dramatic intestinal inflammation in response to dextran sulfate sodium salt (DSS) administration in terms of weight loss, intestinal bleeding, and mortality and showed increased susceptibility to carcinogenesis in response to azoxymethane and DSS.	dss	130-133	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	Mus musculus	21-25
17616656-2	2007	Here, we report that Tir8-deficient mice exhibited a dramatic intestinal inflammation in response to dextran sulfate sodium salt (DSS) administration in terms of weight loss, intestinal bleeding, and mortality and showed increased susceptibility to carcinogenesis in response to azoxymethane and DSS.	dss	296-299	single immunoglobulin and toll-interleukin 1 receptor (TIR) domain	Mus musculus	21-25
17372819-1	2007	The effect of colitis induced with dextran sodium sulfate (DSS) in rats on the bioavailability of drugs transported by the oligopeptide transporter PepT-1 was analyzed by studying the pharmacokinetics of PepT-1 substrates: cephalexin and valacyclovir, the prodrug of antiviral acyclovir.	dss	59-62	solute carrier family 15 member 1	Rattus norvegicus	148-154
17372819-1	2007	The effect of colitis induced with dextran sodium sulfate (DSS) in rats on the bioavailability of drugs transported by the oligopeptide transporter PepT-1 was analyzed by studying the pharmacokinetics of PepT-1 substrates: cephalexin and valacyclovir, the prodrug of antiviral acyclovir.	dss	59-62	solute carrier family 15 member 1	Rattus norvegicus	204-210
17372819-3	2007	We observed (1) no significant modification of PepT-1 expression in the duodenum and jejunum; (2) a slight decrease in both PepT-1 mRNA (50%) and protein expression (25%) in the ileum following DSS challenge; and (3) ectopic PepT-1 immunostaining in regenerative hyperplasia segments in the distal colon from DSS-treated rats where focal inflammation is localized.	dss	194-197	solute carrier family 15 member 1	Rattus norvegicus	124-130
17372819-3	2007	We observed (1) no significant modification of PepT-1 expression in the duodenum and jejunum; (2) a slight decrease in both PepT-1 mRNA (50%) and protein expression (25%) in the ileum following DSS challenge; and (3) ectopic PepT-1 immunostaining in regenerative hyperplasia segments in the distal colon from DSS-treated rats where focal inflammation is localized.	dss	194-197	solute carrier family 15 member 1	Rattus norvegicus	124-130
17229795-4	2007	AIM: To analyse the role of GRK6 in the course of dextran sodium sulphate (DSS)-induced colitis.	dss	75-78	G protein-coupled receptor kinase 6	Mus musculus	28-32
17229795-14	2007	CONCLUSIONS: The intracellular level of GRK6 is an important factor in determining the onset, severity and chronicity of DSS-induced colitis.	dss	121-124	G protein-coupled receptor kinase 6	Mus musculus	40-44
17506908-7	2007	The notable down-regulated genes in the colonic mucosa of mice treated with AOM/DSS were the peroxisome proliferator activated receptor binding protein (Pparbp, 0.06-fold decrease at wk 10) and the transforming growth factor, beta 3 (Tgfb3, 0.14-fold decrease at wk 10).	dss	80-83	mediator complex subunit 1	Mus musculus	93-151
17506908-7	2007	The notable down-regulated genes in the colonic mucosa of mice treated with AOM/DSS were the peroxisome proliferator activated receptor binding protein (Pparbp, 0.06-fold decrease at wk 10) and the transforming growth factor, beta 3 (Tgfb3, 0.14-fold decrease at wk 10).	dss	80-83	mediator complex subunit 1	Mus musculus	153-159
17506908-7	2007	The notable down-regulated genes in the colonic mucosa of mice treated with AOM/DSS were the peroxisome proliferator activated receptor binding protein (Pparbp, 0.06-fold decrease at wk 10) and the transforming growth factor, beta 3 (Tgfb3, 0.14-fold decrease at wk 10).	dss	80-83	transforming growth factor, beta 3	Mus musculus	198-232
17506908-7	2007	The notable down-regulated genes in the colonic mucosa of mice treated with AOM/DSS were the peroxisome proliferator activated receptor binding protein (Pparbp, 0.06-fold decrease at wk 10) and the transforming growth factor, beta 3 (Tgfb3, 0.14-fold decrease at wk 10).	dss	80-83	transforming growth factor, beta 3	Mus musculus	234-239
17506908-8	2007	The inflammation-related gene, peroxisome proliferator activated receptor gamma (Ppargamma 0.38-fold decrease at wk 5), was also down-regulated in the colonic mucosa of mice that received AOM/DSS.	dss	192-195	peroxisome proliferator activated receptor gamma	Mus musculus	31-79
17506908-8	2007	The inflammation-related gene, peroxisome proliferator activated receptor gamma (Ppargamma 0.38-fold decrease at wk 5), was also down-regulated in the colonic mucosa of mice that received AOM/DSS.	dss	192-195	peroxisome proliferator activated receptor gamma	Mus musculus	81-90
17588136-4	2007	RESULTS: DSS significantly decreased bodyweight, colon length, and it increased the incidence of rectal bleeding and levels of MIP-1alpha, MIP-2 and IL-1beta compared to DSS-untreated animals.	dss	9-12	chemokine (C-C motif) ligand 3	Mus musculus	127-137
17437425-14	2007	Stimulated MLN from mice with chronic DSS-induced colitis treated with acteoside showed a significant down-regulation of IFN-gamma secretion (195 pg/ml with 600 microg acteoside versus 612 pg/ml with PBS, P &lt; 0.02).	dss	38-41	interferon gamma	Mus musculus	121-130
17449036-8	2007	RESULTS: The irradiated chimeric lines with iNOS-/- BM-derived cells were markedly more resistant to both DSS- and TNBS-induced injury.	dss	106-109	nitric oxide synthase 2, inducible	Mus musculus	44-48
17449036-9	2007	Resistance to DSS-induced colitis was lost when wild-type (wt) BM was used to reconstitute iNOS-/- mice.	dss	14-17	nitric oxide synthase 2, inducible	Mus musculus	91-95
17449036-10	2007	Neutrophils were the main source of iNOS in DSS-induced colitis.	dss	44-47	nitric oxide synthase 2, inducible	Mus musculus	36-40
17588136-4	2007	RESULTS: DSS significantly decreased bodyweight, colon length, and it increased the incidence of rectal bleeding and levels of MIP-1alpha, MIP-2 and IL-1beta compared to DSS-untreated animals.	dss	9-12	chemokine (C-X-C motif) ligand 2	Mus musculus	139-144
17588136-4	2007	RESULTS: DSS significantly decreased bodyweight, colon length, and it increased the incidence of rectal bleeding and levels of MIP-1alpha, MIP-2 and IL-1beta compared to DSS-untreated animals.	dss	9-12	interleukin 1 beta	Mus musculus	149-157
17213200-13	2007	Administration of dextran sodium sulfate (DSS) significantly increased intestinal permeability in IL-6-/- mice compared with wild type mice given DSS.	dss	42-45	interleukin 6	Mus musculus	98-102
17408638-6	2007	RESULTS: After 12 weeks of treatment with AOM/DSS, Rosa26 Foxm1b transgenic mice showed an increase in the number and size of colorectal tumors compared with wild-type mice.	dss	46-49	gene trap ROSA 26, Philippe Soriano	Mus musculus	51-57
17408638-6	2007	RESULTS: After 12 weeks of treatment with AOM/DSS, Rosa26 Foxm1b transgenic mice showed an increase in the number and size of colorectal tumors compared with wild-type mice.	dss	46-49	forkhead box M1	Mus musculus	58-64
17408638-7	2007	Likewise, a significant reduction in the development and growth of colorectal tumors was found in Villin-Cre Foxm1-/- mice compared with Foxm1 fl/fl mice after AOM/DSS treatment, which was associated with decreased expression of cyclin A2, cyclin B1, survivin, and T-cell factor 4 genes.	dss	164-167	forkhead box M1	Mus musculus	109-114
17408638-7	2007	Likewise, a significant reduction in the development and growth of colorectal tumors was found in Villin-Cre Foxm1-/- mice compared with Foxm1 fl/fl mice after AOM/DSS treatment, which was associated with decreased expression of cyclin A2, cyclin B1, survivin, and T-cell factor 4 genes.	dss	164-167	cyclin A2	Mus musculus	229-238
17408638-7	2007	Likewise, a significant reduction in the development and growth of colorectal tumors was found in Villin-Cre Foxm1-/- mice compared with Foxm1 fl/fl mice after AOM/DSS treatment, which was associated with decreased expression of cyclin A2, cyclin B1, survivin, and T-cell factor 4 genes.	dss	164-167	cyclin B1	Mus musculus	240-249
17408638-7	2007	Likewise, a significant reduction in the development and growth of colorectal tumors was found in Villin-Cre Foxm1-/- mice compared with Foxm1 fl/fl mice after AOM/DSS treatment, which was associated with decreased expression of cyclin A2, cyclin B1, survivin, and T-cell factor 4 genes.	dss	164-167	baculoviral IAP repeat-containing 5	Mus musculus	251-259
17372014-8	2007	Transfer of colon lamina propria F4/80+ macrophages isolated from worm-infected mice induced significant protection from colitis in recipient mice treated with DSS.	dss	160-163	adhesion G protein-coupled receptor E1	Mus musculus	33-38
17342398-4	2007	The effect of systemically administered TFF3 on DSS-induced colitis was assessed.	dss	48-51	trefoil factor 3, intestinal	Mus musculus	40-44
17342398-5	2007	We found increased expression of endogenous TFF3 and increased binding of injected (125)I-TFF3 in the colon of animals with DSS-induced colitis.	dss	124-127	trefoil factor 3, intestinal	Mus musculus	44-48
17342398-5	2007	We found increased expression of endogenous TFF3 and increased binding of injected (125)I-TFF3 in the colon of animals with DSS-induced colitis.	dss	124-127	trefoil factor 3, intestinal	Mus musculus	90-94
17342398-8	2007	Expression of endogenous TFF3 and binding of systemically administered TFF3 are increased in DSS-induced colitis.	dss	93-96	trefoil factor 3, intestinal	Mus musculus	25-29
17342398-8	2007	Expression of endogenous TFF3 and binding of systemically administered TFF3 are increased in DSS-induced colitis.	dss	93-96	trefoil factor 3, intestinal	Mus musculus	71-75
17397543-3	2007	RESULTS: VDR KO mice were extremely sensitive to dextran sodium sulfate (DSS) and there was increased mortality of the VDR KO mice at doses of DSS that only caused a mild form of colitis in wildtype (WT) mice.	dss	73-76	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	9-12
17397543-3	2007	RESULTS: VDR KO mice were extremely sensitive to dextran sodium sulfate (DSS) and there was increased mortality of the VDR KO mice at doses of DSS that only caused a mild form of colitis in wildtype (WT) mice.	dss	143-146	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	9-12
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	19-22
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	tumor necrosis factor	Mus musculus	77-86
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	interleukin 1 alpha	Mus musculus	88-98
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	interleukin 1 beta	Mus musculus	100-108
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	interferon gamma	Mus musculus	117-126
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	interleukin 10	Mus musculus	128-133
17397543-4	2007	DSS colitis in the VDR KO mice was accompanied by high colonic expression of TNF-alpha, IL-1 alpha, IL-1beta, IL-12, IFN-gamma, IL-10, MIP-1alpha and KC.	dss	0-3	chemokine (C-C motif) ligand 3	Mus musculus	135-145
17397543-5	2007	DSS concentrations as low as 0.5% were enough to induce bleeding, ulceration and weight loss in VDR KO mice.	dss	0-3	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	96-99
17397543-6	2007	VDR KO mice failed to recover following the removal of DSS, while WT mice showed signs of recovery within 5 days of DSS removal.	dss	55-58	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	0-3
17397543-7	2007	The early mortality of DSS treated VDR KO mice was likely due to perforation of the bowel and resulting endotoxemia.	dss	23-26	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	35-38
17397543-8	2007	VDR KO mice were hyper-responsive to exogenously injected LPS and cultures of the peritoneal exudates of moribund DSS treated VDR KO mice were positive for bacterial growth.	dss	114-117	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	126-129
17461468-5	2007	Activated NF-kappaB level and IL-1beta and TNF-alpha levels were significantly lower in DSS+PDTC-treated group II.	dss	88-91	interleukin 1 beta	Mus musculus	30-38
17461468-5	2007	Activated NF-kappaB level and IL-1beta and TNF-alpha levels were significantly lower in DSS+PDTC-treated group II.	dss	88-91	tumor necrosis factor	Mus musculus	43-52
17324402-2	2007	The aim of this study was to determine whether CD40-CD40L contributes to the intestinal inflammatory response, tissue injury, and disease activity elicited by dextran sodium sulphate (DSS) through the modulation of leukocyte and platelet recruitment in the colonic microvasculature.	dss	184-187	CD40 antigen	Mus musculus	47-51
17324402-2	2007	The aim of this study was to determine whether CD40-CD40L contributes to the intestinal inflammatory response, tissue injury, and disease activity elicited by dextran sodium sulphate (DSS) through the modulation of leukocyte and platelet recruitment in the colonic microvasculature.	dss	184-187	CD40 ligand	Mus musculus	52-57
17324402-6	2007	RESULTS: A comparison of the responses to DSS-induced colitis in CD40(-/-) and CD40L(-/-) mice to WT mice revealed a significant attenuation of disease activity and histologic damage, as well as profound reductions in the recruitment of adherent leukocytes and platelets in the mutant mice.	dss	42-45	CD40 antigen	Mus musculus	65-69
17324402-7	2007	Similar down-regulation of the blood cell recruitment responses to DSS was noted in WT mice treated with the CD40-CD40L pathway inhibitor Trapidil.	dss	67-70	CD40 antigen	Mus musculus	109-113
17018864-10	2007	Larger increases in tissue substance P were seen in acute than in chronic DSS, whereas CD4 T cells, beta-endorphin and MOR expression were evident only in chronic colitis.	dss	74-77	tachykinin 1	Mus musculus	27-38
17018864-13	2007	Chronic DSS is accompanied by an increase in beta-endorphin and MOR expression, and CD4 T cells, but no change in compliance or CRD responses.	dss	8-11	proopiomelanocortin	Homo sapiens	45-59
17018864-13	2007	Chronic DSS is accompanied by an increase in beta-endorphin and MOR expression, and CD4 T cells, but no change in compliance or CRD responses.	dss	8-11	opioid receptor mu 1	Homo sapiens	64-67
17255317-2	2007	The aims of this study were to assess the role of iNOS in the development of dextran sodium sulfate (DSS)-induced colonic inflammation and to define the contribution of tissue-specific iNOS expression to this inflammatory response.	dss	101-104	nitric oxide synthase 2, inducible	Mus musculus	50-54
17255317-6	2007	Colonic myeloperoxidase (MPO) was comparably elevated in DSS-treated WT mice (30.1+/-1.7) and WT=&gt;WT chimeras (29.0+/-1), whereas MPO was significantly reduced in iNOS-/- mice and iNOS-/-=&gt;WT chimeras (9.5+/-1.7 and 15.6+/-2.2, respectively).	dss	57-60	myeloperoxidase	Mus musculus	25-28
17255317-6	2007	Colonic myeloperoxidase (MPO) was comparably elevated in DSS-treated WT mice (30.1+/-1.7) and WT=&gt;WT chimeras (29.0+/-1), whereas MPO was significantly reduced in iNOS-/- mice and iNOS-/-=&gt;WT chimeras (9.5+/-1.7 and 15.6+/-2.2, respectively).	dss	57-60	myeloperoxidase	Mus musculus	133-136
17255317-6	2007	Colonic myeloperoxidase (MPO) was comparably elevated in DSS-treated WT mice (30.1+/-1.7) and WT=&gt;WT chimeras (29.0+/-1), whereas MPO was significantly reduced in iNOS-/- mice and iNOS-/-=&gt;WT chimeras (9.5+/-1.7 and 15.6+/-2.2, respectively).	dss	57-60	nitric oxide synthase 2, inducible	Mus musculus	166-170
17255317-6	2007	Colonic myeloperoxidase (MPO) was comparably elevated in DSS-treated WT mice (30.1+/-1.7) and WT=&gt;WT chimeras (29.0+/-1), whereas MPO was significantly reduced in iNOS-/- mice and iNOS-/-=&gt;WT chimeras (9.5+/-1.7 and 15.6+/-2.2, respectively).	dss	57-60	nitric oxide synthase 2, inducible	Mus musculus	183-187
17255317-8	2007	Our findings implicate both blood cell- and tissue-derived iNOS in DSS-induced colonic inflammation, with tissue-associated iNOS making a larger contribution to the recruitment of inflammatory cells.	dss	67-70	nitric oxide synthase 2, inducible	Mus musculus	59-63
17211248-6	2007	RESULTS: Ovariectomy increased superoxide production and the expression of NADPH oxidase subunit p22phox mRNA and protein in the aortas of DSS rats fed a high salt diet.	dss	139-142	cytochrome b-245 alpha chain	Rattus norvegicus	97-104
17255259-8	2007	RESULTS: Higher CD8+ T-cell levels correlated with longer OS and DSS, independently of the Follicular Lymphoma International Prognostic Index (OS, P = 0.017; DSS, P = 0.020) and independently of all other prognostic factors (OS, P = 0.001; DSS, P = 0.004).	dss	65-68	CD8a molecule	Homo sapiens	16-19
17324402-7	2007	Similar down-regulation of the blood cell recruitment responses to DSS was noted in WT mice treated with the CD40-CD40L pathway inhibitor Trapidil.	dss	67-70	CD40 ligand	Mus musculus	114-119
17324402-8	2007	CD40 expression in the colonic vasculature was greatly elevated during DSS-induced inflammation in WT mice, but not in CD40(-/-) mice.	dss	71-74	CD40 antigen	Mus musculus	0-4
17324402-9	2007	CONCLUSIONS: These findings implicate CD40-CD40L in the pathogenesis of DSS-induced intestinal inflammation, and suggest that modulation of leukocyte and platelet recruitment by activated, CD40-positive endothelial cells in colonic venules may represent a major action of this signaling pathway.	dss	72-75	CD40 antigen	Mus musculus	38-42
17324402-9	2007	CONCLUSIONS: These findings implicate CD40-CD40L in the pathogenesis of DSS-induced intestinal inflammation, and suggest that modulation of leukocyte and platelet recruitment by activated, CD40-positive endothelial cells in colonic venules may represent a major action of this signaling pathway.	dss	72-75	CD40 ligand	Mus musculus	43-48
17324402-9	2007	CONCLUSIONS: These findings implicate CD40-CD40L in the pathogenesis of DSS-induced intestinal inflammation, and suggest that modulation of leukocyte and platelet recruitment by activated, CD40-positive endothelial cells in colonic venules may represent a major action of this signaling pathway.	dss	72-75	CD40 antigen	Mus musculus	43-47
17077130-14	2007	DSS curves differed significantly between all sixth TNM stages (P &lt; 0.0001).	dss	0-3	teneurin transmembrane protein 1	Homo sapiens	52-55
17130206-9	2006	RESULTS: In unadjusted and adjusted analyses, hyperinsulinemia based on fasting insulin and HOMA at baseline was associated with significantly lower baseline DWR, DSS, and WF scores and a greater decline over 6 years in DWR and WF.	dss	163-166	insulin	Homo sapiens	51-58
17101660-4	2007	Colitis was induced in TFF2 knockout and wild-type mice by administering dextran sodium sulfate (DSS) in drinking water.	dss	97-100	trefoil factor 2 (spasmolytic protein 1)	Mus musculus	23-27
17034586-3	2006	The DSS-treated WT mice exhibited a robust production of IFN-gamma in the gut, a remarkable loss of body weight, as well as high rate of mortality (60%).	dss	4-7	interferon gamma	Mus musculus	57-66
17013685-8	2006	Ki-67 LI &gt;5% (P &lt;.0001) and Mcm2 LI &gt;10% (P &lt;.0001) were strongly predictive of inferior disease-specific survival (DSS), while aberrant loss of p16(INK4A) only reached a trend (P = .0954).	dss	128-131	cyclin dependent kinase inhibitor 2A	Homo sapiens	157-160
17013685-8	2006	Ki-67 LI &gt;5% (P &lt;.0001) and Mcm2 LI &gt;10% (P &lt;.0001) were strongly predictive of inferior disease-specific survival (DSS), while aberrant loss of p16(INK4A) only reached a trend (P = .0954).	dss	128-131	cyclin dependent kinase inhibitor 2A	Homo sapiens	161-166
17024245-7	2006	These results suggest a model whereby the loss of epithelial barrier function by DSS results in the activation of the innate mucosal response by RELMbeta located in the lumen, supporting the hypothesis that this protein is a link among goblet cells, commensal bacteria, and the pathogenesis of IBD.	dss	81-84	resistin like beta	Mus musculus	145-153
16873432-5	2006	Patients with a high level of PRL-3 in the tumor had a worse disease-specific survival (DSS) rate than those with a low level of PRL-3 (74.0% versus 84.9%, P = 0.011), and PRL-3 remained an independent prognostic marker for DSS (HR 1.8, 95% CI 1.1-2.9, P = 0.019) in multivariate analysis.	dss	88-91	protein tyrosine phosphatase 4A3	Homo sapiens	30-35
17072979-10	2006	CONCLUSION: We conclude that DSS induced colitis is markedly attenuated in animals lacking MMP-9.	dss	29-32	matrix metallopeptidase 9	Mus musculus	91-96
17072979-11	2006	This suggests that intestinal injury induced by DSS is modulated by MMP-9 and that inhibition of this gelatinase may reduce inflammation.	dss	48-51	matrix metallopeptidase 9	Mus musculus	68-73
16873432-5	2006	Patients with a high level of PRL-3 in the tumor had a worse disease-specific survival (DSS) rate than those with a low level of PRL-3 (74.0% versus 84.9%, P = 0.011), and PRL-3 remained an independent prognostic marker for DSS (HR 1.8, 95% CI 1.1-2.9, P = 0.019) in multivariate analysis.	dss	224-227	protein tyrosine phosphatase 4A3	Homo sapiens	30-35
16873432-6	2006	More importantly, in 219 node-negative patients, PRL-3 showed a significant correlation with DSS in univariate analysis (P = 0.014) and retained a borderline significance (HR 2.65, 95% CI 0.92-7.64, P = 0.071) in multivariate analysis.	dss	93-96	protein tyrosine phosphatase 4A3	Homo sapiens	49-54
16543288-1	2006	BACKGROUND AND AIMS: alpha-Melanocyte stimulating hormone (alpha MSH) is known to exert anti-inflammatory effects, for example in murine DSS (dextran sodium sulphate induced) colitis.	dss	137-140	pro-opiomelanocortin-alpha	Mus musculus	21-57
16944541-9	2006	A pre-RPLND serum AFP &gt; 9 ng/mL and HCG &gt; 4.1 mIU/mL were found to predict a worse DSS (P = .03 and .03, respectively).	dss	89-92	alpha fetoprotein	Homo sapiens	18-21
16543288-1	2006	BACKGROUND AND AIMS: alpha-Melanocyte stimulating hormone (alpha MSH) is known to exert anti-inflammatory effects, for example in murine DSS (dextran sodium sulphate induced) colitis.	dss	137-140	pro-opiomelanocortin-alpha	Mus musculus	59-68
16826581-7	2006	HIF-1alpha alone was associated with a worse disease-specific survival (DSS) (P =.05) and disease-free survival (DFS) (P = .03) in multivariate analyses.	dss	72-75	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
17008696-6	2006	Kaplan-Meier analysis demonstrated a significant association between NCOA3 overexpression and reduced RFS (P = .021) and DSS (P = .030).	dss	121-124	nuclear receptor coactivator 3	Homo sapiens	69-74
17008696-9	2006	NCOA3 was the most powerful factor predicting DSS, outperforming tumor thickness and ulceration.	dss	46-49	nuclear receptor coactivator 3	Homo sapiens	0-5
17008696-10	2006	CONCLUSION: These results identify NCOA3 as a novel, independent marker of melanoma outcome, with a significant impact on SLN metastasis, RFS, and DSS.	dss	147-150	nuclear receptor coactivator 3	Homo sapiens	35-40
16951375-8	2006	MMP-2 protein expression and activity were up-regulated in WT mice treated with DSS or S.T.	dss	80-83	matrix metallopeptidase 2	Mus musculus	0-5
16951375-9	2006	MMP-2(-/-) mice were highly susceptible to the development of colitis induced by DSS (or S.T.)	dss	81-84	matrix metallopeptidase 2	Mus musculus	0-5
16952555-1	2006	BACKGROUND &amp; AIMS: We recently showed that mice deficient in Toll-like receptor 4 (TLR4) or its adapter molecule MyD88 have increased signs of colitis compared with wild-type (WT) mice after dextran sodium sulfate (DSS)-induced injury.	dss	219-222	toll-like receptor 4	Mus musculus	65-85
16952555-1	2006	BACKGROUND &amp; AIMS: We recently showed that mice deficient in Toll-like receptor 4 (TLR4) or its adapter molecule MyD88 have increased signs of colitis compared with wild-type (WT) mice after dextran sodium sulfate (DSS)-induced injury.	dss	219-222	toll-like receptor 4	Mus musculus	87-91
16952555-1	2006	BACKGROUND &amp; AIMS: We recently showed that mice deficient in Toll-like receptor 4 (TLR4) or its adapter molecule MyD88 have increased signs of colitis compared with wild-type (WT) mice after dextran sodium sulfate (DSS)-induced injury.	dss	219-222	myeloid differentiation primary response gene 88	Mus musculus	117-122
16952555-5	2006	TLR4-/- or WT mice were given 2.5% DSS for 7 days.	dss	35-38	toll-like receptor 4	Mus musculus	0-4
16952555-10	2006	After DSS injury, Cox-2 expression increased only in WT mice.	dss	6-9	prostaglandin-endoperoxide synthase 2	Mus musculus	18-23
16952555-11	2006	TLR4-/- mice have significantly reduced proliferation and increased apoptosis after DSS injury compared with WT mice.	dss	84-87	toll-like receptor 4	Mus musculus	0-4
16826581-9	2006	High HIF-1alpha/high HIF-2alpha expression was an independent prognostic factors in DSS (P = .04) and DFS (P =.005) in multivariate analyses.	dss	84-87	hypoxia inducible factor 1 subunit alpha	Homo sapiens	5-15
16826581-9	2006	High HIF-1alpha/high HIF-2alpha expression was an independent prognostic factors in DSS (P = .04) and DFS (P =.005) in multivariate analyses.	dss	84-87	endothelial PAS domain protein 1	Homo sapiens	21-31
16826581-11	2006	CONCLUSIONS: HIF-1alpha alone was correlated with DSS and DFS.	dss	50-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	13-23
16710473-6	2006	Colonic mucosal injury and colitis induced by dextran sodium sulfate (DSS) are ameliorated in epimorphin-/- mice, probably due to the increased proliferative capacity of the epimorphin-/- colon.	dss	70-73	syntaxin 2	Mus musculus	94-104
16547072-8	2006	The PPARgamma ligand rosiglitazone decreased the severity of DSS induced colitis and suppressed cytokine production in both PPARgamma(F/F) and PPARgamma(DeltaIEpC) mice.	dss	61-64	peroxisome proliferator activated receptor gamma	Mus musculus	4-13
16547072-9	2006	CONCLUSIONS: These studies reveal that PPARgamma expressed in the colonic epithelium has an endogenous role in protection against DSS induced colitis and that rosiglitazone may act through a PPARgamma independent pathway to suppress inflammation.	dss	130-133	peroxisome proliferator activated receptor gamma	Mus musculus	39-48
16890610-6	2006	RESULTS: Treatment with DSS resulted in severe colitis in Mtgr1(-/-) mice, at least partially due to increased epithelial apoptosis rates.	dss	24-27	CBFA2/RUNX1 translocation partner 2	Mus musculus	58-63
16890610-7	2006	Transplantation of wild-type and Mtgr1-null bone marrow into irradiated wild-type mice demonstrated that the severe DSS-induced ulceration seen in Mtgr1-null mice was due to a colonic, rather than a hematologic, defect.	dss	116-119	CBFA2/RUNX1 translocation partner 2	Mus musculus	33-38
16890610-7	2006	Transplantation of wild-type and Mtgr1-null bone marrow into irradiated wild-type mice demonstrated that the severe DSS-induced ulceration seen in Mtgr1-null mice was due to a colonic, rather than a hematologic, defect.	dss	116-119	CBFA2/RUNX1 translocation partner 2	Mus musculus	147-152
16890610-8	2006	Importantly, the epithelium of DSS-treated Mtgr1-null mice failed to completely regenerate, showing changes consistent with chronic colitis, even 10 weeks after a single DSS treatment.	dss	31-34	CBFA2/RUNX1 translocation partner 2	Mus musculus	43-48
16890610-8	2006	Importantly, the epithelium of DSS-treated Mtgr1-null mice failed to completely regenerate, showing changes consistent with chronic colitis, even 10 weeks after a single DSS treatment.	dss	170-173	CBFA2/RUNX1 translocation partner 2	Mus musculus	43-48
16917234-7	2006	RESULTS: After DSS treatment, OPN -/- mice exhibited significantly decreased disease activity compared with wild-type mice, as evidenced by reduced rectal bleeding, weight loss, and histological intestinal injury (P &lt; 0.002).	dss	15-18	secreted phosphoprotein 1	Mus musculus	30-33
16917234-11	2006	Macrophage infiltration into inflamed colonic tissue also was markedly attenuated in DSS-treated OPN -/- mice compared with wild-type mice.	dss	85-88	secreted phosphoprotein 1	Mus musculus	97-100
16848846-8	2006	The Cox regression model by stepwise selection showed as independent prognostic factors for disease-specific survival (DSS), the occurrence of a local relapse (p &lt; 0.0001), pN status (p &lt; 0.0001), the type of surgery (p &lt; 0.0001), and the use of radiotherapy (p &lt; 0.0006) and chemotherapy (p = 0.01).	dss	119-122	cytochrome c oxidase subunit 8A	Homo sapiens	4-7
16790781-3	2006	Colitis was induced in wild-type (wt), TLR-2 knockout, and TLR-4 knockout mice via administration of 5% dextran sodium sulfate (DSS).	dss	128-131	toll-like receptor 4	Mus musculus	59-64
16790781-5	2006	wt and TLR-2 knockout mice exposed to DSS developed acute colitis, whereas TLR-4 knockout mice developed significantly less inflammation.	dss	38-41	toll-like receptor 2	Mus musculus	7-12
16631617-8	2006	Both placebo and DSS meals increased urinary F(2)-isoprostanes at 1h but not thereafter, and lowered urinary 8OHdG levels, DBP and AIx, and increased HR.	dss	17-20	D-box binding PAR bZIP transcription factor	Homo sapiens	123-126
16698153-9	2006	CLA and n-3 PUFA acted synergistically to upregulate colonic KGF expression in DSS-challenged pigs but n-3 PUFA blocked CLA-induced PPAR gamma activation.	dss	79-82	Polyunsaturated fatty acid percentage	Sus scrofa	12-16
16698153-9	2006	CLA and n-3 PUFA acted synergistically to upregulate colonic KGF expression in DSS-challenged pigs but n-3 PUFA blocked CLA-induced PPAR gamma activation.	dss	79-82	fibroblast growth factor 7	Sus scrofa	61-64
16968411-11	2006	Inhibition of CTSD in mouse DSS colitis was followed by an amelioration of the disease.	dss	28-31	cathepsin D	Mus musculus	14-18
16547072-6	2006	Increased susceptibility to DSS induced colitis, as defined by body weight loss, colon length, diarrhoea, bleeding score, and altered histology, was found in PPARgamma(DeltaIEpC) mice in comparison with PPARgamma(F/F) mice.	dss	28-31	peroxisome proliferator activated receptor gamma	Mus musculus	158-167
16547072-6	2006	Increased susceptibility to DSS induced colitis, as defined by body weight loss, colon length, diarrhoea, bleeding score, and altered histology, was found in PPARgamma(DeltaIEpC) mice in comparison with PPARgamma(F/F) mice.	dss	28-31	peroxisome proliferator activated receptor gamma	Mus musculus	203-212
16547072-7	2006	Interleukin (IL)-6, IL-1beta, and tumour necrosis factor alpha mRNA levels in colons of PPARgamma(DeltaIEpC) mice treated with DSS were higher than in similarly treated PPARgamma(F/F) mice.	dss	127-130	interleukin 6	Mus musculus	0-18
16547072-7	2006	Interleukin (IL)-6, IL-1beta, and tumour necrosis factor alpha mRNA levels in colons of PPARgamma(DeltaIEpC) mice treated with DSS were higher than in similarly treated PPARgamma(F/F) mice.	dss	127-130	interleukin 1 beta	Mus musculus	20-28
16547072-7	2006	Interleukin (IL)-6, IL-1beta, and tumour necrosis factor alpha mRNA levels in colons of PPARgamma(DeltaIEpC) mice treated with DSS were higher than in similarly treated PPARgamma(F/F) mice.	dss	127-130	peroxisome proliferator activated receptor gamma	Mus musculus	88-97
16890610-5	2006	METHODS: Mtgr1-null mice were given 3% DSS in their drinking water for 4 days and the colons examined at various times thereafter for ulceration and for changes in proliferation and apoptosis.	dss	39-42	CBFA2/RUNX1 translocation partner 2	Mus musculus	9-14
16865770-3	2006	Univariate and multivariate survival analyses were used to assess the value of these two E-cadherin indices as predictors of both disease-free (DFS) and disease-specific (DSS) survival.	dss	171-174	cadherin 1	Homo sapiens	89-99
16796922-11	2006	(2) In the tissue sections NF-kappaB p65 was positive mainly in the nucleus in the 3 DSS-treated groups without significant differences among these 3 groups, and was mainly positive in the cytoplasm in the control group.	dss	85-88	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	37-40
16944023-3	2006	To clarify the behavior of those cells in the injury or regeneration phase, we investigated Msi-1 expressing cells of intestinal mucosa in the murine model of dextran sodium sulfate (DSS)-induced colitis.	dss	183-186	musashi RNA-binding protein 1	Mus musculus	92-97
16944023-6	2006	In contrast, the number of Msi-1-positive cells decreased slightly with DSS but returned to normal after DSS administration was stopped.	dss	72-75	musashi RNA-binding protein 1	Mus musculus	27-32
16944023-6	2006	In contrast, the number of Msi-1-positive cells decreased slightly with DSS but returned to normal after DSS administration was stopped.	dss	105-108	musashi RNA-binding protein 1	Mus musculus	27-32
16520739-5	2006	Relaxation induced by SLIGRL-NH(2), a selective PAR-2-activating peptide, was also reduced in DSS-treated rat colon.	dss	94-97	F2R like trypsin receptor 1	Rattus norvegicus	48-53
16520739-7	2006	Expression of PAR-2 mRNA in colonic muscularis externa was significantly lower in DSS-treated rats than in control rats.	dss	82-85	F2R like trypsin receptor 1	Rattus norvegicus	14-19
16299037-9	2006	DHNA significantly attenuated the enhanced expression of MAdCAM-1, the increased beta7 positive cell number, and the increased mRNA levels of IL-1beta, IL-6, and TNF-alpha in DSS treated colon.	dss	175-178	interleukin 1 beta	Mus musculus	142-150
16821635-4	2006	A significant correlation with worse disease-specific survival period (DSS) in the group of patients demonstrating Mcm-2 protein expression in over 10% of cancer cells was detected (5-year cumulative DSS 50% vs. 76%).	dss	71-74	minichromosome maintenance complex component 2	Homo sapiens	115-120
16821635-4	2006	A significant correlation with worse disease-specific survival period (DSS) in the group of patients demonstrating Mcm-2 protein expression in over 10% of cancer cells was detected (5-year cumulative DSS 50% vs. 76%).	dss	200-203	minichromosome maintenance complex component 2	Homo sapiens	115-120
16630028-2	2006	Recently it has been demonstrated that p38MAPK (mitogen-activated protein kinase) inhibition using SB203580 is effective in reducing disease in both dextran sulphate sodium (DSS)-induced and 2,4,6-trinitrobenzenesulphonic acid (TNBS)-induced murine colitides, underscoring the importance of this pathway in gastrointestinal inflammation.	dss	174-177	mitogen-activated protein kinase 14	Mus musculus	39-46
16630028-5	2006	Our studies in mice with DSS-induced colitis treated with the JNK inhibitor SP600125, indicate that there is a significant reduction in wasting as well as a significant reduction in histological damage scores.	dss	25-28	mitogen-activated protein kinase 8	Mus musculus	62-65
16630028-12	2006	We conclude that specific inhibition of JNK is beneficial in the DSS model of colitis, and may be of value in human IBD.	dss	65-68	mitogen-activated protein kinase 8	Homo sapiens	40-43
16299037-9	2006	DHNA significantly attenuated the enhanced expression of MAdCAM-1, the increased beta7 positive cell number, and the increased mRNA levels of IL-1beta, IL-6, and TNF-alpha in DSS treated colon.	dss	175-178	interleukin 6	Mus musculus	152-156
16299037-9	2006	DHNA significantly attenuated the enhanced expression of MAdCAM-1, the increased beta7 positive cell number, and the increased mRNA levels of IL-1beta, IL-6, and TNF-alpha in DSS treated colon.	dss	175-178	tumor necrosis factor	Mus musculus	162-171
16427211-5	2006	A statistically significant increase in DSS was observed among the 143 patients with DM absent when patients with prostate-specific antigen (PSA) less than 20 were compared with those with PSA greater than 20 at the time salvage HT was started.	dss	40-43	kallikrein related peptidase 3	Homo sapiens	114-145
16482101-4	2006	In this study, we examined the pathophysiological role of the beta(2) integrins CD18, CD11a, and CD11b in the pathogenesis of dextran sodium sulfte (DSS)-induced experimental colitis.	dss	149-152	integrin beta 2	Mus musculus	80-84
16482101-4	2006	In this study, we examined the pathophysiological role of the beta(2) integrins CD18, CD11a, and CD11b in the pathogenesis of dextran sodium sulfte (DSS)-induced experimental colitis.	dss	149-152	integrin alpha L	Mus musculus	86-91
16482101-4	2006	In this study, we examined the pathophysiological role of the beta(2) integrins CD18, CD11a, and CD11b in the pathogenesis of dextran sodium sulfte (DSS)-induced experimental colitis.	dss	149-152	integrin alpha M	Mus musculus	97-102
16482101-10	2006	Surprisingly, the CD11b null mice showed a significant increase in plasma cell infiltration in response to DSS suggesting that this molecule may influence plasma cell function during colitis.	dss	107-110	integrin alpha M	Mus musculus	18-23
16427211-5	2006	A statistically significant increase in DSS was observed among the 143 patients with DM absent when patients with prostate-specific antigen (PSA) less than 20 were compared with those with PSA greater than 20 at the time salvage HT was started.	dss	40-43	kallikrein related peptidase 3	Homo sapiens	141-144
16162679-6	2006	RESULTS: IL-15 KO mice exhibited resistance to DSS induced acute colitis, as reflected by lower lethality, weight loss, clinical scores, and histological scores compared with those in control mice (p&lt;0.05).	dss	47-50	interleukin 15	Mus musculus	9-14
16551853-7	2006	Kaplan-Meier analysis showed that high epithelial and stromal expression of MMP-2, MMP-9, and MT1-MMP were each significantly associated with shorter disease-specific survival (DSS; P &lt; 0.01).	dss	177-180	matrix metallopeptidase 2	Homo sapiens	76-81
16551853-7	2006	Kaplan-Meier analysis showed that high epithelial and stromal expression of MMP-2, MMP-9, and MT1-MMP were each significantly associated with shorter disease-specific survival (DSS; P &lt; 0.01).	dss	177-180	matrix metallopeptidase 9	Homo sapiens	83-88
16551853-7	2006	Kaplan-Meier analysis showed that high epithelial and stromal expression of MMP-2, MMP-9, and MT1-MMP were each significantly associated with shorter disease-specific survival (DSS; P &lt; 0.01).	dss	177-180	matrix metallopeptidase 14	Homo sapiens	94-101
16551853-10	2006	CONCLUSIONS: Overexpression of stromal MMP-9 and MT1-MMP is independently associated with shorter DSS in EOC.	dss	98-101	matrix metallopeptidase 9	Homo sapiens	39-44
16551853-10	2006	CONCLUSIONS: Overexpression of stromal MMP-9 and MT1-MMP is independently associated with shorter DSS in EOC.	dss	98-101	matrix metallopeptidase 14	Homo sapiens	49-56
16162679-3	2006	Here we investigated the involvement of IL-15 in the pathogenesis of acute and chronic dextran sulphate sodium (DSS) induced colitis.	dss	112-115	interleukin 15	Mus musculus	40-45
16162679-10	2006	CONCLUSIONS: IL-15 plays an important role in the pathogenesis of both acute and chronic colitis induced by DSS in mice.	dss	108-111	interleukin 15	Mus musculus	13-18
15856265-7	2006	RESULTS: Significant changes in MAdCAM-1 were observed in mice with chronic DSS-induced colitis.	dss	76-79	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	32-40
16309852-6	2006	Multivariate analysis revealed that PSA status after treatment had the most significant effect on DSS.	dss	98-101	aminopeptidase puromycin sensitive	Homo sapiens	36-39
16540796-7	2006	RESULTS: PPARgamma mRNA levels were low, with DSS suppressing mRNA levels equally in WT and cftr mice.	dss	46-49	cystic fibrosis transmembrane conductance regulator	Mus musculus	92-96
16540796-12	2006	PPARalpha mice treated with DSS did not develop bile duct injury, indicating that PPARalpha alone is not sufficient to cause bile duct inflammation.	dss	28-31	peroxisome proliferator activated receptor alpha	Mus musculus	0-9
16540796-13	2006	CONCLUSION: DSS induced bile duct injury in cftr mice is associated with a defect in PPARalpha expression, which is reversed by DHA.	dss	12-15	cystic fibrosis transmembrane conductance regulator	Mus musculus	44-48
16540796-13	2006	CONCLUSION: DSS induced bile duct injury in cftr mice is associated with a defect in PPARalpha expression, which is reversed by DHA.	dss	12-15	peroxisome proliferator activated receptor alpha	Mus musculus	85-94
16409585-11	2006	The difference in prognosis determined by using the Cox versus the log-normal model ranged for DFI from 1.2% to 8.1%, and for DSS from 0.4% to 6.2%; interestingly, the difference was more substantial for patients with a high risk of recurrence or death from breast cancer.	dss	126-129	cytochrome c oxidase subunit 8A	Homo sapiens	52-55
16426010-13	2006	TLR5 expression is down-regulated in vivo during acute and chronic DSS-induced colitis, in contrast to the expression of TLR2, TLR4, and CD14.	dss	67-70	toll-like receptor 5	Mus musculus	0-4
16049979-7	2006	Adenocarcinomas developed in Apc(Min/+) mice that received DSS showed loss of heterozygosity of Apc and no mutations in the beta-catenin and K-ras genes.	dss	59-62	APC, WNT signaling pathway regulator	Mus musculus	29-32
16049979-7	2006	Adenocarcinomas developed in Apc(Min/+) mice that received DSS showed loss of heterozygosity of Apc and no mutations in the beta-catenin and K-ras genes.	dss	59-62	APC, WNT signaling pathway regulator	Mus musculus	96-99
16049979-9	2006	Sequential observation revealed increase in the incidences of colonic neoplasms and dysplastic crypts in female Apc(Min/+) mice given DSS.	dss	134-137	APC, WNT signaling pathway regulator	Mus musculus	112-115
16049979-10	2006	DSS treatment increased inflammation scores, associated with high intensity staining of beta-catenin, cyclooxygenase-2, inducible nitric oxide synthase and nitrotyrosine.	dss	0-3	catenin (cadherin associated protein), beta 1	Mus musculus	88-100
16049979-10	2006	DSS treatment increased inflammation scores, associated with high intensity staining of beta-catenin, cyclooxygenase-2, inducible nitric oxide synthase and nitrotyrosine.	dss	0-3	prostaglandin-endoperoxide synthase 2	Mus musculus	102-118
16428491-6	2006	Furthermore, co-overexpression of Skp2 and cyclin A identified highly lethal cases in the entire cohort [P &lt; 0.0001 for disease-specific survival (DSS), P = 0.0004 for overall survival (OS)] and the lower-grade subset (Federation Nationale des Centres de Lutte Contre le Cancer grade 1 and 2; P = 0.0006 for DSS, P = 0.0093 for OS).	dss	150-153	S-phase kinase associated protein 2	Homo sapiens	34-38
16428491-6	2006	Furthermore, co-overexpression of Skp2 and cyclin A identified highly lethal cases in the entire cohort [P &lt; 0.0001 for disease-specific survival (DSS), P = 0.0004 for overall survival (OS)] and the lower-grade subset (Federation Nationale des Centres de Lutte Contre le Cancer grade 1 and 2; P = 0.0006 for DSS, P = 0.0093 for OS).	dss	150-153	cyclin A2	Homo sapiens	43-51
16428491-6	2006	Furthermore, co-overexpression of Skp2 and cyclin A identified highly lethal cases in the entire cohort [P &lt; 0.0001 for disease-specific survival (DSS), P = 0.0004 for overall survival (OS)] and the lower-grade subset (Federation Nationale des Centres de Lutte Contre le Cancer grade 1 and 2; P = 0.0006 for DSS, P = 0.0093 for OS).	dss	311-314	S-phase kinase associated protein 2	Homo sapiens	34-38
16428491-7	2006	In multivariate analyses, Skp2 overexpression overshadowed most intrinsic clinicopathologic factors and independently correlated with worse metastasis-free survival (P = 0.0012), DSS (P = 0.0234), and OS (P = 0.0056).	dss	179-182	S-phase kinase associated protein 2	Homo sapiens	26-30
16049979-11	2006	Interestingly, strong nuclear staining of p53 was specifically observed in colonic lesions of Apc(Min/+) mice treated with DSS.	dss	123-126	transformation related protein 53, pseudogene	Mus musculus	42-45
16049979-11	2006	Interestingly, strong nuclear staining of p53 was specifically observed in colonic lesions of Apc(Min/+) mice treated with DSS.	dss	123-126	APC, WNT signaling pathway regulator	Mus musculus	94-97
17347588-4	2006	METHOD: Inflammatory colitis was induced by treatment with 1% dextran sodium sulfate (DSS) in drinking water for 1 week in Mlh1 knockout (Mlh1(-/-)), Mlh1 heterozygous (Mlh1(+/-)) and wild-type (Mlh1(+/+)) mice at 10 weeks of age.	dss	86-89	mutL homolog 1	Mus musculus	123-127
16049979-12	2006	Our results suggest a strong promotion effect of DSS in the intestinal carcinogenesis of Apc(Min/+) mice.	dss	49-52	APC, WNT signaling pathway regulator	Mus musculus	89-92
17347588-6	2006	RESULTS: Male and female Mlh1(-/-) mice with DSS showed a 63 and 44% incidence of tumors, respectively, whereas no tumors were observed in Mlh1(+/-) and Mlh1(+/+) mice.	dss	45-48	mutL homolog 1	Mus musculus	25-29
16099872-6	2005	These findings indicate that LIX plays an integral role in the pathogenesis of DSS-induced colitis.	dss	79-82	chemokine (C-X-C motif) ligand 5	Mus musculus	29-32
16099872-4	2005	Consistent with the expression pattern of ENA-78 in IBD, LIX expression is significantly increased in mice with colitis induced by the ingestion of dextran sodium sulfate (DSS).	dss	172-175	C-X-C motif chemokine ligand 5	Homo sapiens	42-48
16174100-5	2005	When mice developed DSS-induced colitis, CD3+CD8+B220+ gammadelta T cells increased in PP in the small intestine.	dss	20-23	CD3 antigen, epsilon polypeptide	Mus musculus	41-44
16099872-4	2005	Consistent with the expression pattern of ENA-78 in IBD, LIX expression is significantly increased in mice with colitis induced by the ingestion of dextran sodium sulfate (DSS).	dss	172-175	chemokine (C-X-C motif) ligand 5	Mus musculus	57-60
16232212-2	2005	The objective of this study was to find out if short-term treatment of CD44 antibodies specific to CD44v7, but not to other variant isoforms, suppresses leucocyte-endothelial interaction in chronic dextran sodium sulphate (DSS)-induced colitis in mice.	dss	223-226	CD44 antigen	Mus musculus	71-75
16232212-9	2005	In chronic DSS-induced colitis both CD44 variant isoforms, v4 and v7 were significantly up-regulated on mononuclear cells.	dss	11-14	CD44 antigen	Mus musculus	36-40
16045730-5	2005	The level of myeloperoxidase (MPO) activity in colon tissues was increased by DSS administration in both TLR4(-/-) and WT mice.	dss	78-81	myeloperoxidase	Mus musculus	13-28
16143131-7	2005	Treatment of wt mice with chronic DSS-induced colitis with AV-ODN resulted in a significant amelioration of disease with a reduced histologic score (-43%) and reduced cytokine production of MLC (interleukin [IL]-6: -68%; interferon [IFN]-gamma: -48%) and RNA expression of the T helper (Th)1-specific transcription factor T-bet (-62%) in colonic tissue.	dss	34-37	T-box 21	Mus musculus	322-327
16045730-5	2005	The level of myeloperoxidase (MPO) activity in colon tissues was increased by DSS administration in both TLR4(-/-) and WT mice.	dss	78-81	myeloperoxidase	Mus musculus	30-33
16045730-5	2005	The level of myeloperoxidase (MPO) activity in colon tissues was increased by DSS administration in both TLR4(-/-) and WT mice.	dss	78-81	toll-like receptor 4	Mus musculus	105-109
16045730-6	2005	The expression of MIF was up-regulated in the colons of TLR4(-/-) mice with acute DSS-induced colitis.	dss	82-85	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	18-21
16045730-6	2005	The expression of MIF was up-regulated in the colons of TLR4(-/-) mice with acute DSS-induced colitis.	dss	82-85	toll-like receptor 4	Mus musculus	56-60
16045730-8	2005	The current results obtained from TLR4(-/-) mice provide evidence that MIF plays a critical role in the development of acute DSS-induced colitis.	dss	125-128	toll-like receptor 4	Mus musculus	34-38
16045730-8	2005	The current results obtained from TLR4(-/-) mice provide evidence that MIF plays a critical role in the development of acute DSS-induced colitis.	dss	125-128	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	71-74
15885661-2	2005	In this study, we investigated intestinal Pgp expression and activity: (1) in IL10 deficient (IL10(-/-)) mice which spontaneously develop intestinal inflammation affecting the small and large intestine and (2) in DSS (dextran sodium sulfate)-induced rat colitis.	dss	213-216	phosphoglycolate phosphatase	Mus musculus	42-45
15880135-5	2005	Furthermore, CD98 was highly upregulated in colonic tissues from mice with active colitis induced by dextran sodium sulfate (DSS), but not in DSS-treated INF gamma -/- mice.	dss	125-128	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	13-17
15880135-6	2005	Administration of an anti-CD98 antibody worsened DSS-induced colitis in mice but had no effect on untreated control mice.	dss	49-52	solute carrier family 3 (activators of dibasic and neutral amino acid transport), member 2	Mus musculus	26-30
15880135-7	2005	Finally, we used Caco2-BBE cell monolayers to model intestinal epithelial wound healing, and found that activation of epithelial CD98 in DSS-treated monolayers inhibited monolayer reconstitution, but had no affect on untreated control monolayers.	dss	137-140	solute carrier family 3 member 2	Homo sapiens	129-133
15885661-6	2005	However, in the non-inflamed ileum in DSS-induced rat colitis, epithelial cell"s Pgp activity and protein levels were unexpectedly increased.	dss	38-41	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	81-84
15885661-9	2005	They also show an increase in Pgps activity in the non-inflamed ileum in the DSS-induced rat colitis, which may represent an adaptive mechanism to compensate the impaired activity of Pgp in the colon.	dss	77-80	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	30-33
15915372-9	2005	At 19.1 months" median follow-up, factors associated with improved DSS included an initial clinical response to IL-2 therapy (P &lt; .001) and a higher administered dose (P = .04).	dss	67-70	interleukin 2	Homo sapiens	112-116
15932518-5	2005	In vivo, preventive HO-1 induction by CoPP in acute dextran sodium sulphate (DSS)-induced colitis led to a significant down-regulation of colonic inflammation (P &lt; 0.01) with a concomitant reduction in interferon (IFN)-gamma - but unaffected interleukin (IL)-10-secretion by isolated mesenteric lymph nodes (P &lt; 0.01).	dss	77-80	heme oxygenase 1	Homo sapiens	20-24
15932518-5	2005	In vivo, preventive HO-1 induction by CoPP in acute dextran sodium sulphate (DSS)-induced colitis led to a significant down-regulation of colonic inflammation (P &lt; 0.01) with a concomitant reduction in interferon (IFN)-gamma - but unaffected interleukin (IL)-10-secretion by isolated mesenteric lymph nodes (P &lt; 0.01).	dss	77-80	interferon gamma	Homo sapiens	205-227
15932518-5	2005	In vivo, preventive HO-1 induction by CoPP in acute dextran sodium sulphate (DSS)-induced colitis led to a significant down-regulation of colonic inflammation (P &lt; 0.01) with a concomitant reduction in interferon (IFN)-gamma - but unaffected interleukin (IL)-10-secretion by isolated mesenteric lymph nodes (P &lt; 0.01).	dss	77-80	interleukin 10	Homo sapiens	245-264
15826931-7	2005	DSS treatment of TLR4-/- mice was associated with striking reduction in acute inflammatory cells compared with wild-type mice despite similar degrees of epithelial injury.	dss	0-3	toll-like receptor 4	Mus musculus	17-21
15890569-9	2005	RESULTS: On univariate analysis, EGFR positivity was significantly associated with improved overall survival (p = 0.044); disease-specific survival (DSS) (p = 0.042); and DSS with intact bladder (p = 0.021).	dss	149-152	epidermal growth factor receptor	Homo sapiens	33-37
15890569-9	2005	RESULTS: On univariate analysis, EGFR positivity was significantly associated with improved overall survival (p = 0.044); disease-specific survival (DSS) (p = 0.042); and DSS with intact bladder (p = 0.021).	dss	171-174	epidermal growth factor receptor	Homo sapiens	33-37
15890569-11	2005	On multivariate analysis adding tumor stage, tumor grade, whether a visibly complete transurethral resection of bladder tumor (TURBT) was done or not, and patient age to the model, EGFR positivity was significantly associated with improved DSS.	dss	240-243	epidermal growth factor receptor	Homo sapiens	181-185
15550557-6	2005	DSS induced a rapid and sustained increase in vascular permeability that was greatly attenuated in P-selectin-deficient mice.	dss	0-3	selectin, platelet	Mus musculus	99-109
15915372-12	2005	CONCLUSIONS: The initial clinical response to IL-2 therapy is an independent predictor of improved outcome associated with DSS and the 720,000 IU/kg dose.	dss	123-126	interleukin 2	Homo sapiens	46-50
15807847-2	2005	To further investigate this matter, we examined the pathological features of MIF transgenic mice with dextran sulphate sodium (DSS)-induced colitis.	dss	127-130	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	77-80
15807847-9	2005	The severity of the colitis induced by 1% DSS treatment was markedly higher in MIF transgenic mice than in wild-type mice.	dss	42-45	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	79-82
15807847-10	2005	We also found that MPO activity was significantly higher in MIF transgenic mice than wild-type mice in response to DSS stimulation.	dss	115-118	myeloperoxidase	Mus musculus	19-22
15807847-10	2005	We also found that MPO activity was significantly higher in MIF transgenic mice than wild-type mice in response to DSS stimulation.	dss	115-118	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	60-63
15807847-12	2005	MIF enhances DSS-induced colitis, in part via neutrophil accumulation and inhibition of glucocorticoid bioactivity.	dss	13-16	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	0-3
15866230-11	2005	Serum amyloid A (acute phase protein; P=.0015) and tumor necrosis factor-alpha (TNF-alpha; pro-inflammatory cytokine; P&lt;.01) were significantly increased in DSS-treated animals (161+/-40 pg/ml) and improved with antioxidant treatment (P&lt;.01).	dss	160-163	tumor necrosis factor	Mus musculus	51-78
15866230-11	2005	Serum amyloid A (acute phase protein; P=.0015) and tumor necrosis factor-alpha (TNF-alpha; pro-inflammatory cytokine; P&lt;.01) were significantly increased in DSS-treated animals (161+/-40 pg/ml) and improved with antioxidant treatment (P&lt;.01).	dss	160-163	tumor necrosis factor	Mus musculus	80-89
15883736-10	2005	Indeed, treatment with rofecoxib diminished the lost of COX-1 caused by DSS in the crypt epithelium whereas expression of COX-2 remained unaffected.	dss	72-75	cytochrome c oxidase I, mitochondrial	Mus musculus	56-61
15764810-5	2005	After DSS discontinuation, mice rapidly gained weight, ulcers were healed, and colonic NT, NTR1, and cyclooxygenase (COX)-2 mRNA levels were upregulated, whereas SR-48642 treatment caused a further body weight loss, ulcer enlargement, and a blunted colonic COX-2 mRNA upregulation.	dss	6-9	neurotensin receptor 1	Mus musculus	91-95
15804292-4	2005	When exposed to dextran sulphate sodium (DSS) IL-2+/- mice showed a markedly reduced susceptibility to DSS-induced colitis.	dss	41-44	interleukin 2	Mus musculus	46-50
15804292-4	2005	When exposed to dextran sulphate sodium (DSS) IL-2+/- mice showed a markedly reduced susceptibility to DSS-induced colitis.	dss	103-106	interleukin 2	Mus musculus	46-50
15804292-5	2005	While DSS treatment caused a marked increase in both CD4+ and CD8+ colonic T cells expressing increased levels of IL-2, IL-4, and IL-10 in wild type mice none of these changes were seen in IL-2+/- mice.	dss	6-9	interleukin 2	Mus musculus	114-118
15804292-5	2005	While DSS treatment caused a marked increase in both CD4+ and CD8+ colonic T cells expressing increased levels of IL-2, IL-4, and IL-10 in wild type mice none of these changes were seen in IL-2+/- mice.	dss	6-9	interleukin 4	Mus musculus	120-124
15804292-5	2005	While DSS treatment caused a marked increase in both CD4+ and CD8+ colonic T cells expressing increased levels of IL-2, IL-4, and IL-10 in wild type mice none of these changes were seen in IL-2+/- mice.	dss	6-9	interleukin 10	Mus musculus	130-135
15804292-6	2005	On the contrary, cytokine expression in intestinal T cells of IL-2+/- mice was actually reduced after DSS treatment.	dss	102-105	interleukin 2	Mus musculus	62-66
15804292-7	2005	These results suggest that reduced levels of IL-2 leads to attenuated activation and function of intestinal T cells in IL-2+/- mice and a failure to react adequately to DSS exposure.	dss	169-172	interleukin 2	Mus musculus	45-49
15730387-0	2005	Increased lymphocyte trafficking to colonic microvessels is dependent on MAdCAM-1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis.	dss	115-118	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	73-105
15664663-8	2005	RESULTS: Luminal treatment with TFF3 in its dimeric form significantly improved the colitis score in both colitis models, whereas TFF2 had positive effect only in DSS-induced colitis.	dss	163-166	trefoil factor 2	Rattus norvegicus	130-134
15730387-0	2005	Increased lymphocyte trafficking to colonic microvessels is dependent on MAdCAM-1 and C-C chemokine mLARC/CCL20 in DSS-induced mice colitis.	dss	115-118	chemokine (C-C motif) ligand 20	Mus musculus	106-111
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	3-6	chemokine (C-C motif) ligand 20	Mus musculus	49-54
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	3-6	chemokine (C-C motif) ligand 20	Mus musculus	55-60
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	3-6	chemokine (C-C motif) ligand 20	Mus musculus	106-111
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	3-6	chemokine (C-C motif) ligand 20	Mus musculus	112-117
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	3-6	chemokine (C-C motif) receptor 6	Mus musculus	167-171
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	3-6	chemokine (C-C motif) ligand 20	Mus musculus	106-111
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	3-6	chemokine (C-C motif) ligand 20	Mus musculus	112-117
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	218-221	chemokine (C-C motif) ligand 20	Mus musculus	49-54
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	218-221	chemokine (C-C motif) ligand 20	Mus musculus	55-60
15735556-3	2005	RESULTS: The DSS treated MT-TG and MT-KO mice responded in a manner similar to that of DSS treated WT mice, with all groups developing severe colitis.	dss	13-16	tRNA glycine, mitochondrial	Mus musculus	25-30
15735556-5	2005	The colonic and blood levels of the antioxidant, glutathione (GSH), were significantly reduced in DSS treated MT-TG and MT-KO mice.	dss	98-101	tRNA glycine, mitochondrial	Mus musculus	110-115
16158079-3	2005	The time and PSA threshold model demonstrates the ability to prognosticate OS and DSS as early as 3 months post-radiotherapy for prostate cancer.	dss	82-85	kallikrein related peptidase 3	Homo sapiens	13-16
15723650-8	2005	Immunohistochemical investigation revealed that adnocarcinomas, induced by DMH at all doses and 2%DSS, showed positive reactivities against beta-catenin, COX-2 and iNOS.	dss	98-101	catenin (cadherin associated protein), beta 1	Mus musculus	140-152
15723650-8	2005	Immunohistochemical investigation revealed that adnocarcinomas, induced by DMH at all doses and 2%DSS, showed positive reactivities against beta-catenin, COX-2 and iNOS.	dss	98-101	cytochrome c oxidase II, mitochondrial	Mus musculus	154-159
15723650-8	2005	Immunohistochemical investigation revealed that adnocarcinomas, induced by DMH at all doses and 2%DSS, showed positive reactivities against beta-catenin, COX-2 and iNOS.	dss	98-101	nitric oxide synthase 2, inducible	Mus musculus	164-168
15723650-9	2005	In DMH/DSS-induced adenocarcinomas, 10 of 11 (90.9%) adenocacrcinomas had beta-catenin gene mutations.	dss	7-10	catenin (cadherin associated protein), beta 1	Mus musculus	74-86
15601431-2	2004	Vanilloid receptor type 1 (TRPV1) has been visualized on nerve terminals of intrinsic and extrinsic afferent neurones innervating the gastrointestinal tract and local administration of a TRPV1 antagonist, capsazepine, reduces the severity of dextran sulphate sodium (DSS)-induced colitis in rats (Gut 2003; 52: 713-9(1)).	dss	267-270	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
15601431-2	2004	Vanilloid receptor type 1 (TRPV1) has been visualized on nerve terminals of intrinsic and extrinsic afferent neurones innervating the gastrointestinal tract and local administration of a TRPV1 antagonist, capsazepine, reduces the severity of dextran sulphate sodium (DSS)-induced colitis in rats (Gut 2003; 52: 713-9(1)).	dss	267-270	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	187-192
15601431-5	2004	An experimental TRPV1 antagonist given orally was tested against DSS-induced colitis, and shown to reverse the macroscopic damage score at doses of 0.5 and 5.0 mg kg(-1).	dss	65-68	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	16-21
15521012-8	2004	When mice were treated with 3% DSS in drinking water for 6 days followed by distilled water without DSS, 72% of HGFA-deficient mice died through day 12 while 75% of control mice survived injury.	dss	31-34	hepatocyte growth factor activator	Mus musculus	112-116
15338270-9	2004	The expression of AQP4 and AQP8 mRNA was significantly decreased after 12-24 h of DSS exposure and remained depressed throughout the treatment period.	dss	82-85	aquaporin 4	Homo sapiens	18-22
15338270-9	2004	The expression of AQP4 and AQP8 mRNA was significantly decreased after 12-24 h of DSS exposure and remained depressed throughout the treatment period.	dss	82-85	aquaporin 8	Homo sapiens	27-31
15730387-9	2005	In DSS-treated colonic tissue, the expression of mLARC/CCL20 was significantly increased, the blocking of mLARC/CCL20 by monoclonal antibody or the desensitization of CCR6 with mLARC/CCL20 significantly attenuated the DSS-induced T and B cell accumulation.	dss	218-221	chemokine (C-C motif) receptor 6	Mus musculus	167-171
15730387-11	2005	These results suggest that in chronic DSS-induced colitis, both MAdCAM-1 and mLARC/CCL20 may play important roles in T and B lymphocyte adhesion in the inflamed colon under flow conditions.	dss	38-41	mucosal vascular addressin cell adhesion molecule 1	Mus musculus	64-82
15730387-11	2005	These results suggest that in chronic DSS-induced colitis, both MAdCAM-1 and mLARC/CCL20 may play important roles in T and B lymphocyte adhesion in the inflamed colon under flow conditions.	dss	38-41	chemokine (C-C motif) ligand 20	Mus musculus	83-88
15531237-3	2004	Previous reports have indicated that inhibition of VR-1 with capsazepine (CPZ), a VR-1 antagonist, attenuates dextran sodium sulfate (DSS) colitis in rats.	dss	134-137	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-55
15521012-8	2004	When mice were treated with 3% DSS in drinking water for 6 days followed by distilled water without DSS, 72% of HGFA-deficient mice died through day 12 while 75% of control mice survived injury.	dss	100-103	hepatocyte growth factor activator	Mus musculus	112-116
15087277-5	2004	iNOS mRNA and protein levels were increased throughout the tissue from DSS-treated mice and, notably, in the myenteric plexus, where the majority of iNOS immunoreactivity colocalized with the enteric glial cell marker glial fibrillary acidic protein.	dss	71-74	nitric oxide synthase 2, inducible	Mus musculus	0-4
15545172-5	2004	RESULTS: In the colon mucosa, DSS treatment increased myeloperoxidase activity (P &lt; 0.05), oxidative DNA damage (P &lt; 0.01), and cyclooxygenase-2 (COX-2) expression (P &lt; 0.01) and reduced superoxide dismutase-2 (SOD-2) expression (P &lt; 0.05).	dss	30-33	myeloperoxidase	Rattus norvegicus	54-69
15545172-5	2004	RESULTS: In the colon mucosa, DSS treatment increased myeloperoxidase activity (P &lt; 0.05), oxidative DNA damage (P &lt; 0.01), and cyclooxygenase-2 (COX-2) expression (P &lt; 0.01) and reduced superoxide dismutase-2 (SOD-2) expression (P &lt; 0.05).	dss	30-33	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	134-150
15545172-5	2004	RESULTS: In the colon mucosa, DSS treatment increased myeloperoxidase activity (P &lt; 0.05), oxidative DNA damage (P &lt; 0.01), and cyclooxygenase-2 (COX-2) expression (P &lt; 0.01) and reduced superoxide dismutase-2 (SOD-2) expression (P &lt; 0.05).	dss	30-33	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	152-157
15545172-5	2004	RESULTS: In the colon mucosa, DSS treatment increased myeloperoxidase activity (P &lt; 0.05), oxidative DNA damage (P &lt; 0.01), and cyclooxygenase-2 (COX-2) expression (P &lt; 0.01) and reduced superoxide dismutase-2 (SOD-2) expression (P &lt; 0.05).	dss	30-33	superoxide dismutase 2	Rattus norvegicus	196-218
15545172-5	2004	RESULTS: In the colon mucosa, DSS treatment increased myeloperoxidase activity (P &lt; 0.05), oxidative DNA damage (P &lt; 0.01), and cyclooxygenase-2 (COX-2) expression (P &lt; 0.01) and reduced superoxide dismutase-2 (SOD-2) expression (P &lt; 0.05).	dss	30-33	superoxide dismutase 2	Rattus norvegicus	220-225
15545172-10	2004	CONCLUSIONS: Mild acute intestinal inflammation induced by DSS can be inhibited by 4-CA and this action is associated with the suppression of COX-2 expression and activity.	dss	59-62	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	142-147
15331912-1	2004	The objective of the present study was to determine the effect of a selective cyclooxygenase-2 (COX-2) inhibitor in in-vivo dextran sodium sulfate (DSS)-stimulated distal colon tissues of the rat.	dss	148-151	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	78-94
15331912-1	2004	The objective of the present study was to determine the effect of a selective cyclooxygenase-2 (COX-2) inhibitor in in-vivo dextran sodium sulfate (DSS)-stimulated distal colon tissues of the rat.	dss	148-151	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	96-101
15364967-5	2004	RESULTS: Among those patients with localized disease at diagnosis, median and 5-year disease-specific survivals (DSS) for the SYT-SSX1 and SYT-SSX2 subgroups were 126 months and 67.4% versus 82 months and 63.2%, respectively (P = .12).	dss	113-116	synaptotagmin 1	Homo sapiens	126-134
15364967-5	2004	RESULTS: Among those patients with localized disease at diagnosis, median and 5-year disease-specific survivals (DSS) for the SYT-SSX1 and SYT-SSX2 subgroups were 126 months and 67.4% versus 82 months and 63.2%, respectively (P = .12).	dss	113-116	synaptotagmin 1	Homo sapiens	126-129
15087277-5	2004	iNOS mRNA and protein levels were increased throughout the tissue from DSS-treated mice and, notably, in the myenteric plexus, where the majority of iNOS immunoreactivity colocalized with the enteric glial cell marker glial fibrillary acidic protein.	dss	71-74	nitric oxide synthase 2, inducible	Mus musculus	149-153
15013990-11	2004	EcN administration to DSS-treated mice reduced the secretion of proinflammatory cytokines (IFN-gamma, 32,477 +/- 6,377 versus 9,734 +/- 1,717 [P = 0.004]; IL-6, 231 +/- 35 versus 121 +/- 17 [P = 0.02]) but had no effect on the mucosal inflammation.	dss	22-25	interferon gamma	Mus musculus	91-100
15362034-11	2004	Loss of the PPAR gamma gene in the colon abrogated the beneficial effects of CLA in DSS colitis.	dss	84-87	peroxisome proliferator activated receptor gamma	Mus musculus	12-22
15253727-7	2004	RESULTS: Kallikrein gene delivery resulted in reduced blood urea nitrogen (BUN), urinary protein and albumin levels in DSS rats on a high salt diet.	dss	119-122	kallikrein related peptidase 4	Homo sapiens	9-19
15253727-11	2004	CONCLUSION: These results indicate that tissue kallikrein protects against renal fibrosis in hypertensive DSS rats through increased nitric oxide bioavailability and suppression of oxidative stress and TGF-beta expression.	dss	106-109	kallikrein related peptidase 4	Homo sapiens	47-57
15082590-3	2004	AIMS: To establish a new colitis associated neoplasia model in p53 deficient mice by treatment with dextran sulphate sodium (DSS).	dss	125-128	transformation related protein 53, pseudogene	Mus musculus	63-66
15082590-4	2004	METHODS: DSS colitis was induced in homozygous p53 deficient mice (p53(-/-)-DSS), heterozygous p53 deficient mice (p53(+/-)-DSS) and wild-type mice (p53+/+-DSS) by treatment with 4% DSS.	dss	9-12	transformation related protein 53, pseudogene	Mus musculus	47-50
15082590-7	2004	RESULTS: p53(-/-)-DSS mice showed 100% incidence of neoplasias whereas the incidences in p53(+/-)-DSS and p53+/+-DSS mice were 46.2% and 13.3%, respectively.	dss	18-21	transformation related protein 53, pseudogene	Mus musculus	9-12
15082590-7	2004	RESULTS: p53(-/-)-DSS mice showed 100% incidence of neoplasias whereas the incidences in p53(+/-)-DSS and p53+/+-DSS mice were 46.2% and 13.3%, respectively.	dss	98-101	transformation related protein 53, pseudogene	Mus musculus	89-92
15082590-7	2004	RESULTS: p53(-/-)-DSS mice showed 100% incidence of neoplasias whereas the incidences in p53(+/-)-DSS and p53+/+-DSS mice were 46.2% and 13.3%, respectively.	dss	98-101	transformation related protein 53, pseudogene	Mus musculus	89-92
15082590-7	2004	RESULTS: p53(-/-)-DSS mice showed 100% incidence of neoplasias whereas the incidences in p53(+/-)-DSS and p53+/+-DSS mice were 46.2% and 13.3%, respectively.	dss	98-101	transformation related protein 53, pseudogene	Mus musculus	89-92
15082590-7	2004	RESULTS: p53(-/-)-DSS mice showed 100% incidence of neoplasias whereas the incidences in p53(+/-)-DSS and p53+/+-DSS mice were 46.2% and 13.3%, respectively.	dss	98-101	transformation related protein 53, pseudogene	Mus musculus	89-92
15082590-10	2004	The number of neoplasias per mouse in the p53(-/-)-DSS group was significantly higher than that in the other DSS groups.	dss	51-54	transformation related protein 53, pseudogene	Mus musculus	42-45
15030527-4	2004	The expression of cathepsin D in intestinal mucosa was analysed by immunohistochemistry in biopsies from IBD and control patients and in a mouse model of dextran sulphate sodium (DSS)-induced acute and chronic colitis.	dss	179-182	cathepsin D	Homo sapiens	18-29
15138478-5	2004	In univariate analysis, the patients with low tumour cystatin C levels exhibited poor disease-free survival (DFS, P=0.013) and disease-specific survival (DSS, P=0.013).	dss	154-157	cystatin C	Homo sapiens	53-63
15013990-11	2004	EcN administration to DSS-treated mice reduced the secretion of proinflammatory cytokines (IFN-gamma, 32,477 +/- 6,377 versus 9,734 +/- 1,717 [P = 0.004]; IL-6, 231 +/- 35 versus 121 +/- 17 [P = 0.02]) but had no effect on the mucosal inflammation.	dss	22-25	interleukin 6	Mus musculus	155-159
14750238-4	2004	Patients with high levels of bcl-6 expression had favorable overall survival (OS) (P = .003), disease-specific survival (DSS) (P = .033), and time to treatment failure (P = .003) compared with patients with low levels of bcl-6 expression.	dss	121-124	BCL6 transcription repressor	Homo sapiens	29-34
15082590-14	2004	CONCLUSIONS: The p53(-/-)-DSS mice is an excellent animal model of UC associated neoplasia because the morphological features and molecular genetics are similar to those of UC associated neoplasia.	dss	26-29	transformation related protein 53, pseudogene	Mus musculus	17-20
15043303-15	2004	The 5-year PFS and DSS were significantly worse for carcinomas with a TP53 mutation (22.6% vs. 41.2% progressed [P = 0.04]; 21.7% vs. 24.7% died [P = 0.04]).	dss	19-22	tumor protein p53	Homo sapiens	70-74
14750238-6	2004	Patients with CD10+ FLs also had longer OS (P = .001), DSS (P = .007), and time to treatment failure (P = .004), and grade 1 FL was associated with better OS (P = .01) and a statistical trend for longer DSS (P = .05) and time to treatment failure (P = .05), but these results were not independent of bcl-6 expression or the international prognostic index in multivariate analysis.	dss	55-58	membrane metalloendopeptidase	Homo sapiens	14-18
15231456-5	2004	DSS and sinigrin were evaluated for their inhibitory effects on cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, on lipid peroxidation, and on the proliferation of human colon (HCT-116), breast (MCF-7), lung (NCIH460), and central nervous system (CNS, SF-268) cancer cell lines.	dss	0-3	prostaglandin-endoperoxide synthase 2	Homo sapiens	93-109
12940437-2	2003	The present study was conducted to determine the distinct roles of IL-12 and IL-18 in the development of dextran sulphate sodium (DSS) colitis in mice.	dss	130-133	interleukin 18	Mus musculus	77-82
14762789-10	2004	The severity of DSS-induced colitis in TLR2 and TLR4 deficient mice was significantly decreased by i.g.	dss	16-19	toll-like receptor 2	Mus musculus	39-43
14762789-10	2004	The severity of DSS-induced colitis in TLR2 and TLR4 deficient mice was significantly decreased by i.g.	dss	16-19	toll-like receptor 4	Mus musculus	48-52
12740917-4	2003	In postmenopausal women, DSS was significantly predicted by cyclin E, and in premenopausal patients by cyclin B.	dss	25-28	proliferating cell nuclear antigen	Homo sapiens	60-66
12948843-8	2003	In the DSS group, PG-SPI and PG-KII decreased the percentage of surviving animals, and increased the number of rats that developed loose stools and blood in the faeces and the MPO activity.	dss	7-10	myeloperoxidase	Rattus norvegicus	176-179
12939233-10	2003	Both Nos2 and Ace have been disqualified as QTLs in the DSS and LEW comparison.	dss	56-59	nitric oxide synthase 2	Rattus norvegicus	5-9
12939233-10	2003	Both Nos2 and Ace have been disqualified as QTLs in the DSS and LEW comparison.	dss	56-59	angiotensin I converting enzyme	Rattus norvegicus	14-17
12587118-2	2003	In this study, we examined the expression of P-gp in dextran sodium sulfate (DSS)-induced colitis in mice.	dss	77-80	phosphoglycolate phosphatase	Mus musculus	45-49
12587118-11	2003	In addition, the P-gp function and the expression of PXR were also reduced in the large intestine of DSS-treated mice on day 3.	dss	101-104	phosphoglycolate phosphatase	Mus musculus	17-21
12587118-11	2003	In addition, the P-gp function and the expression of PXR were also reduced in the large intestine of DSS-treated mice on day 3.	dss	101-104	nuclear receptor subfamily 1, group I, member 2	Mus musculus	53-56
12940437-8	2003	LPMCs from DSS-fed IL-18(-/-) mice produced significantly higher amounts of IFN-gamma, while LPMCs from DSS-fed IL-12(-/-) mice produced lower amounts of IFN-gamma and tumour necrosis factor (TNF)-alpha compared with control mice.	dss	11-14	interleukin 18	Mus musculus	19-24
12940437-8	2003	LPMCs from DSS-fed IL-18(-/-) mice produced significantly higher amounts of IFN-gamma, while LPMCs from DSS-fed IL-12(-/-) mice produced lower amounts of IFN-gamma and tumour necrosis factor (TNF)-alpha compared with control mice.	dss	11-14	interferon gamma	Mus musculus	76-85
12940437-8	2003	LPMCs from DSS-fed IL-18(-/-) mice produced significantly higher amounts of IFN-gamma, while LPMCs from DSS-fed IL-12(-/-) mice produced lower amounts of IFN-gamma and tumour necrosis factor (TNF)-alpha compared with control mice.	dss	104-107	interferon gamma	Mus musculus	154-163
12940437-8	2003	LPMCs from DSS-fed IL-18(-/-) mice produced significantly higher amounts of IFN-gamma, while LPMCs from DSS-fed IL-12(-/-) mice produced lower amounts of IFN-gamma and tumour necrosis factor (TNF)-alpha compared with control mice.	dss	104-107	tumor necrosis factor	Mus musculus	168-202
12665123-7	2003	In addition, challenge with DSS increased the colonic content of myeloperoxidase (MPO).	dss	28-31	myeloperoxidase	Mus musculus	65-80
12665123-7	2003	In addition, challenge with DSS increased the colonic content of myeloperoxidase (MPO).	dss	28-31	myeloperoxidase	Mus musculus	82-85
12665123-9	2003	Moreover, in roquinimex treated animals, the MPO activity was significantly reduced by more than 50% compared to DSS control mice.	dss	113-116	myeloperoxidase	Mus musculus	45-48
12665123-10	2003	Notably, therapeutic administration of roquinimex in DSS-treated mice also significantly inhibited the MDS, CH-reduction and MPO activity.	dss	53-56	myeloperoxidase	Mus musculus	125-128
12473598-8	2002	However, patients with tumors demonstrating down-regulation of p27, a cyclin-dependent kinase inhibitor and tumor suppressor gene associated with development of metastases, showed a trend toward reduced DFS and DSS (P = 0.06 and P = 0.07, respectively).	dss	211-214	interferon alpha inducible protein 27	Homo sapiens	63-66
12473598-10	2002	However, down-regulation of p27 appears to be associated with a trend toward reduced DFS and DSS, which suggests further investigation of other p27-related pathways potentially relevant for metastatic disease.	dss	93-96	interferon alpha inducible protein 27	Homo sapiens	28-31
12479648-4	2002	Increased susceptibility to dextran sodium sulfate (DSS)-induced colitis as defined by body weights, histologic injury, and survival was observed in the PPARgamma(+/-) mice in comparison to wild-type mice.	dss	52-55	peroxisome proliferator activated receptor gamma	Mus musculus	153-162
12572868-4	2002	METHODS: We performed a global analysis for differential gene expression of the intestine in a dextran sodium sulfate (DSS) colitis mouse model following PPARgamma ligand administration.	dss	119-122	peroxisome proliferator activated receptor gamma	Mus musculus	154-163
12572868-6	2002	RESULTS: The analysis of downregulated genes in the DSS mice following PPARgamma administration revealed several functional gene clusters with altered expression: (1) oncogene families such as GRO1 oncogenes, (2) inflammatory mediator-related genes such as the interferon-gamma gene, (3) water electrolyte-associated genes, and (4) others.	dss	52-55	peroxisome proliferator activated receptor gamma	Mus musculus	71-80
12572868-6	2002	RESULTS: The analysis of downregulated genes in the DSS mice following PPARgamma administration revealed several functional gene clusters with altered expression: (1) oncogene families such as GRO1 oncogenes, (2) inflammatory mediator-related genes such as the interferon-gamma gene, (3) water electrolyte-associated genes, and (4) others.	dss	52-55	chemokine (C-X-C motif) ligand 1	Mus musculus	193-197
12572868-7	2002	CONCLUSIONS: This is the first demonstration of global gene expression analysis using the DSS colitis mouse model with a PPARgamma ligand, and these results provide new insight for finding novel target genes for treating IBD.	dss	90-93	peroxisome proliferator activated receptor gamma	Mus musculus	121-130
12376619-4	2002	gammadelta IEL in DSS treated mice expressed keratinocyte growth factor (KGF), a potent intestinal epithelial cell mitogen.	dss	18-21	fibroblast growth factor 7	Mus musculus	45-71
12376619-4	2002	gammadelta IEL in DSS treated mice expressed keratinocyte growth factor (KGF), a potent intestinal epithelial cell mitogen.	dss	18-21	fibroblast growth factor 7	Mus musculus	73-76
12479648-7	2002	The reduction in DSS-induced inflammation noted with PPARgamma ligand treatment was associated with decreased interferon-gamma and tumor necrosis factor-alpha and increased interleukin (IL)-4 and IL- 10 levels as assessed by quantitative reverse transcriptase-polymerase chain reaction.	dss	17-20	peroxisome proliferator activated receptor gamma	Mus musculus	53-62
12479648-7	2002	The reduction in DSS-induced inflammation noted with PPARgamma ligand treatment was associated with decreased interferon-gamma and tumor necrosis factor-alpha and increased interleukin (IL)-4 and IL- 10 levels as assessed by quantitative reverse transcriptase-polymerase chain reaction.	dss	17-20	interferon gamma	Mus musculus	110-158
12479648-7	2002	The reduction in DSS-induced inflammation noted with PPARgamma ligand treatment was associated with decreased interferon-gamma and tumor necrosis factor-alpha and increased interleukin (IL)-4 and IL- 10 levels as assessed by quantitative reverse transcriptase-polymerase chain reaction.	dss	17-20	interleukin 4	Mus musculus	173-191
12479648-7	2002	The reduction in DSS-induced inflammation noted with PPARgamma ligand treatment was associated with decreased interferon-gamma and tumor necrosis factor-alpha and increased interleukin (IL)-4 and IL- 10 levels as assessed by quantitative reverse transcriptase-polymerase chain reaction.	dss	17-20	interleukin 10	Mus musculus	196-202
11978890-5	2002	We evaluated E-GPx levels in a mouse model of IBD using dextran sodium sulfate (DSS).	dss	80-83	glutathione peroxidase 3	Mus musculus	13-18
12395901-6	2002	After DSS was withdrawn, disease activity subsided gradually and HGF expression was significantly enhanced along with the augmented expression of IL-1beta, TNF-alpha, and cyclooxygenase-2, accompanied by an increased number of proliferating epithelial cells in colon.	dss	6-9	hepatocyte growth factor	Rattus norvegicus	65-68
12395901-6	2002	After DSS was withdrawn, disease activity subsided gradually and HGF expression was significantly enhanced along with the augmented expression of IL-1beta, TNF-alpha, and cyclooxygenase-2, accompanied by an increased number of proliferating epithelial cells in colon.	dss	6-9	interleukin 1 beta	Rattus norvegicus	146-154
12395901-6	2002	After DSS was withdrawn, disease activity subsided gradually and HGF expression was significantly enhanced along with the augmented expression of IL-1beta, TNF-alpha, and cyclooxygenase-2, accompanied by an increased number of proliferating epithelial cells in colon.	dss	6-9	tumor necrosis factor	Rattus norvegicus	156-165
12395901-6	2002	After DSS was withdrawn, disease activity subsided gradually and HGF expression was significantly enhanced along with the augmented expression of IL-1beta, TNF-alpha, and cyclooxygenase-2, accompanied by an increased number of proliferating epithelial cells in colon.	dss	6-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	171-187
12171963-9	2002	The higher susceptibility of homozygous alpha(1)-AGP-transgenic mice to DSS induced acute colitis was also reflected in higher local myeloperoxidase levels, higher inflammation scores of the colon, and higher systemic levels of interleukin 6 and serum amyloid P component.	dss	72-75	myeloperoxidase	Mus musculus	133-148
12171963-9	2002	The higher susceptibility of homozygous alpha(1)-AGP-transgenic mice to DSS induced acute colitis was also reflected in higher local myeloperoxidase levels, higher inflammation scores of the colon, and higher systemic levels of interleukin 6 and serum amyloid P component.	dss	72-75	interleukin 6	Mus musculus	228-241
12010883-11	2002	CONCLUSIONS: IL-18bp treatment attenuated inflammation during DSS induced colitis in mice.	dss	62-65	interleukin 18 binding protein	Mus musculus	13-20
11978890-8	2002	Western blot analysis demonstrated a 64% increase in E-GPx protein in the plasma of the DSS group after 7 d of treatment (p &lt; 0.01).	dss	88-91	glutathione peroxidase 3	Mus musculus	53-58
11978890-10	2002	After 3 and 7 d of DSS treatment, E-GPx mRNA levels, relative to glyceraldehyde-3-phosphate dehydrogenase, increased in the kidney (p &lt; 0.05) without a concomitant increase in cellular GPx mRNA on d 7.	dss	19-22	glutathione peroxidase 3	Mus musculus	34-39
11978890-10	2002	After 3 and 7 d of DSS treatment, E-GPx mRNA levels, relative to glyceraldehyde-3-phosphate dehydrogenase, increased in the kidney (p &lt; 0.05) without a concomitant increase in cellular GPx mRNA on d 7.	dss	19-22	glyceraldehyde-3-phosphate dehydrogenase	Mus musculus	65-105
11934816-6	2002	In DSS-treated mice, mRNA of both P- and E-selectin were expressed and leukocyte rolling and adhesion was increased to 27+/-3 cells min(-1) and 36+/-8 cells mm(-1), respectively.	dss	3-6	selectin, endothelial cell	Mus musculus	41-51
11948499-5	2002	With 25 patients dead of PC and a median follow-up of surviving patients of 71 months (range 48-144), the prognostic relevance of Her-2 expression was univariately associated with adverse outcome in terms of biochemical or clinical progression-free survival (B/C-PFS; p = 0.04), clinical progression-free survival (C-PFS; p = 0.02) and disease-specific survival (DSS; p = 0.02).	dss	363-366	erb-b2 receptor tyrosine kinase 2	Homo sapiens	130-135
11948499-7	2002	Her-2 expression and Gleason score together discriminated 2 groups of patients with 5-year DSS of 95% and 79%, respectively (p &lt; 0.001).	dss	91-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
11934816-7	2002	An anti-P-selectin antibody abolished DSS-induced leukocyte rolling, whereas an antibody against E-selectin had no effect.	dss	38-41	selectin, platelet	Mus musculus	8-18
11934816-10	2002	DSS markedly increased production of TNF-alpha in the colon.	dss	0-3	tumor necrosis factor	Mus musculus	37-46
11440827-12	2001	The number of infiltrating cells and the expression of mucosal adressin cell adhesion molecule-1 were significantly attenuated in the DSS-treated colon of iNOS-deficient mice.	dss	134-137	nitric oxide synthase 2, inducible	Mus musculus	155-159
12058955-6	2002	RESULTS: DSS increased DAI, MDS, MPO activity and TNF-alpha production and decreased CH.	dss	9-12	myeloperoxidase	Mus musculus	33-36
12058955-6	2002	RESULTS: DSS increased DAI, MDS, MPO activity and TNF-alpha production and decreased CH.	dss	9-12	tumor necrosis factor	Mus musculus	50-59
11750290-2	2002	RESULTS: The patient"s father and paternal grandmother were heterozygotes for the Int8/5"-dss/t(+2)c allele, while the patient"s mother and maternal grandmother were heterozygotes for the G154V allele.	dss	90-93	integrator complex subunit 8	Homo sapiens	82-86
12010883-6	2002	METHODS: Mice with dextran sulphate sodium (DSS) induced colitis were treated with recombinant IL-18 binding protein (IL-18bp.Fc), a soluble protein that blocks IL-18 bioactivity.	dss	44-47	interleukin 18	Homo sapiens	95-100
12010883-6	2002	METHODS: Mice with dextran sulphate sodium (DSS) induced colitis were treated with recombinant IL-18 binding protein (IL-18bp.Fc), a soluble protein that blocks IL-18 bioactivity.	dss	44-47	interleukin 18 binding protein	Mus musculus	118-125
12010883-6	2002	METHODS: Mice with dextran sulphate sodium (DSS) induced colitis were treated with recombinant IL-18 binding protein (IL-18bp.Fc), a soluble protein that blocks IL-18 bioactivity.	dss	44-47	interleukin 18	Mus musculus	118-123
12010883-8	2002	RESULTS: IL-18 RNA levels increased very early in the colon during DSS colitis.	dss	67-70	interleukin 18	Mus musculus	9-14
12010883-9	2002	Treatment of mice with IL-18bp.Fc inhibited IBD associated weight loss and significantly inhibited the intestinal inflammation induced by DSS.	dss	138-141	interleukin 18 binding protein	Mus musculus	23-30
11729120-15	2001	Dysplasia in Min-DSS occurs through LOH of Apc.	dss	17-20	APC, WNT signaling pathway regulator	Mus musculus	43-46
11289109-6	2001	In the third experiment, dietary administration (0.01% in diet for 6 weeks) of pioglitazone (PPARgamma ligand), troglitazone, and bezafibrate effectively suppressed DSS/AOM-induced ACF.	dss	165-168	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	93-102
11560292-3	2001	The concept system is intended for use as an aid in the construction of a decision support system (DSS) for urinary tract infections, and as a search module in the mentioned DSS.	dss	99-102	activation induced cytidine deaminase	Homo sapiens	45-48
11238559-4	2001	BiP protein, a marker of ER stress, was elevated in the colonic mucosa of IRE1beta(-/-) mice, and, when exposed to dextran sodium sulfate (DSS) to induce inflammatory bowel disease, mutant mice developed colitis 3-5 days earlier than did wild-type or IRE1beta(+/-) mice.	dss	139-142	heat shock protein 5	Mus musculus	0-3
11222363-5	2001	The probability of DSS at 10 years after diagnosis of cGVHD (DSS1) and after PTF (DSS2) was 51% (95% confidence interval [CI] = 39%, 60%) and 38% (95% CI = 28%, 49%), respectively.	dss	19-22	SEM1 26S proteasome subunit	Homo sapiens	61-65
11238559-5	2001	The inflammation marker ICAM-1 was also expressed earlier in the colonic mucosa of DSS-treated IRE1beta(-/-) mice, indicating that the mutation had its impact early in the inflammatory process, before the onset of mucosal ulceration.	dss	83-86	intercellular adhesion molecule 1	Mus musculus	24-30
11238559-5	2001	The inflammation marker ICAM-1 was also expressed earlier in the colonic mucosa of DSS-treated IRE1beta(-/-) mice, indicating that the mutation had its impact early in the inflammatory process, before the onset of mucosal ulceration.	dss	83-86	endoplasmic reticulum (ER) to nucleus signalling 2	Mus musculus	95-103
11305514-7	2001	Moreover, this fucoidan treatment markedly reduced the colonic MPO activity in mice exposed to DSS.	dss	95-98	myeloperoxidase	Mus musculus	63-66
11305515-1	2001	BACKGROUND: Transforming growth factor-alpha (TGF-alpha) is a key mediator of colonic mucosal protection and/or repair mechanisms in orally induced acute dextran sodium sulphate (DSS) colitis.	dss	179-182	transforming growth factor alpha	Mus musculus	12-44
11305515-1	2001	BACKGROUND: Transforming growth factor-alpha (TGF-alpha) is a key mediator of colonic mucosal protection and/or repair mechanisms in orally induced acute dextran sodium sulphate (DSS) colitis.	dss	179-182	transforming growth factor alpha	Mus musculus	46-55
11305515-13	2001	CONCLUSIONS: The markedly increased severity of mucosal injury in chronic induced DSS colitis in TGF-alpha deficient wa-1 mice compared to Balb/c mice further substantiates that endogenous TGF-alpha is a pivotal mediator of protection and/or healing mechanisms in the colon.	dss	82-85	transforming growth factor alpha	Mus musculus	97-106
11305515-13	2001	CONCLUSIONS: The markedly increased severity of mucosal injury in chronic induced DSS colitis in TGF-alpha deficient wa-1 mice compared to Balb/c mice further substantiates that endogenous TGF-alpha is a pivotal mediator of protection and/or healing mechanisms in the colon.	dss	82-85	transforming growth factor alpha	Mus musculus	189-198
10837943-5	2000	For this study a DSS event was declared if: 1) death was certified as due to CAP; 2) death was due to complications of treatment; or 3) death was from unknown causes with active malignancy.	dss	17-20	cyclase associated actin cytoskeleton regulatory protein 2	Homo sapiens	77-83
11231946-6	2001	RESULTS: DSS induced similar disease onset in MT1-bGH-TG and WT.	dss	9-12	metallothionein 1	Mus musculus	46-49
11231946-9	2001	Colonic IL-1beta was elevated in DSS-treated MT1-bGH-TG and WT, but IL-1beta mRNA abundance correlated with disease only in WT.	dss	33-36	interleukin 1 beta	Mus musculus	8-16
11231946-9	2001	Colonic IL-1beta was elevated in DSS-treated MT1-bGH-TG and WT, but IL-1beta mRNA abundance correlated with disease only in WT.	dss	33-36	metallothionein 1	Mus musculus	45-48
11289109-4	2001	In the first experiment, gastric gavage of troglitazone (PPARgamma ligand, 10 or 100 mg/kg body weight) or bezafibrate (PPARalpha ligand, 10 or 100 mg/kg body weight) inhibited colitis induced by dextran sodium sulfate (DSS) and lowered trefoil factor-2 content in colonic mucosa.	dss	220-223	peroxisome proliferator activated receptor alpha	Rattus norvegicus	120-129
11093954-2	2000	In this study, our aim was to investigate whether the intraperitoneal administration of a nonpeptide neurokinin-1 (NK-1) antagonist, CP-96345, which antagonizes the binding of SP to its NK-1 receptor, results in the attenuation of colonic inflammation induced in rats by 5% dextran sodium sulfate (DSS) in drinking water for 10 days compared with an inactive enantiomer, CP-96344.	dss	298-301	tachykinin receptor 1	Rattus norvegicus	186-199
11254085-3	2000	In the control strain the immunohistochemical staining showed a very pronounced endothelial upregulation of ICAM-1 after the DSS treatment observed in areas of inflammatory infiltrate, especially in venules or arterioles of the propria and submucosa, and partly in the mesocolon.	dss	125-128	intercellular adhesion molecule 1	Mus musculus	108-114
10986555-10	2000	These results indicate that human AM gene delivery protects against salt-induced hypertension and cardiac and renal lesions in DSS rats via activation of cAMP as a second messenger.	dss	127-130	adrenomedullin	Homo sapiens	34-36
10843684-3	2000	Both CCR2- and CCR5-deficient mice were susceptible to DSS-induced intestinal inflammation.	dss	55-58	chemokine (C-C motif) receptor 2	Mus musculus	5-9
10843684-3	2000	Both CCR2- and CCR5-deficient mice were susceptible to DSS-induced intestinal inflammation.	dss	55-58	chemokine (C-C motif) receptor 5	Mus musculus	15-19
10843684-5	2000	However, both CCR5-deficient mice and, to a lesser degree, CCR2-deficient mice were protected from DSS-induced intestinal adhesions and mucosal ulcerations.	dss	99-102	chemokine (C-C motif) receptor 5	Mus musculus	14-18
10843684-5	2000	However, both CCR5-deficient mice and, to a lesser degree, CCR2-deficient mice were protected from DSS-induced intestinal adhesions and mucosal ulcerations.	dss	99-102	chemokine (C-C motif) receptor 2	Mus musculus	59-63
11196714-4	2000	IL-5 deficient mice were studied using the dextran sulphate sodium (DSS)-induced colitis model and the results compared to a congenic IL-5+/+ strain.	dss	68-71	interleukin 5	Mus musculus	0-4
10783320-4	2000	The aim of this study was to test the effect of nimesulide, a preferential COX-2 inhibitor, on the DSS-induced 8-oxodGuo increase.	dss	99-102	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	75-80
10759763-0	2000	Therapeutic effect of intracolonically administered nuclear factor kappa B (p65) antisense oligonucleotide on mouse dextran sulphate sodium (DSS)-induced colitis.	dss	141-144	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	76-79
10759763-1	2000	Cytokines such as IL-1, tumour necrosis factor-alpha (TNF-alpha), IL-6 and IL-8 are increased in inflamed colonic mucosa after administration of mouse DSS.	dss	151-154	interleukin 1 complex	Mus musculus	18-22
10759763-1	2000	Cytokines such as IL-1, tumour necrosis factor-alpha (TNF-alpha), IL-6 and IL-8 are increased in inflamed colonic mucosa after administration of mouse DSS.	dss	151-154	tumor necrosis factor	Mus musculus	54-63
10759763-1	2000	Cytokines such as IL-1, tumour necrosis factor-alpha (TNF-alpha), IL-6 and IL-8 are increased in inflamed colonic mucosa after administration of mouse DSS.	dss	151-154	interleukin 6	Mus musculus	66-70
10759763-1	2000	Cytokines such as IL-1, tumour necrosis factor-alpha (TNF-alpha), IL-6 and IL-8 are increased in inflamed colonic mucosa after administration of mouse DSS.	dss	151-154	chemokine (C-X-C motif) ligand 15	Mus musculus	75-79
10759763-3	2000	The effect of intracolonically administered NF-kappaB (p65) antisense phosphorothioate oligonucleotide was examined in mouse DSS-induced colitis using drinking water containing 5% DSS.	dss	125-128	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	44-53
10759764-1	2000	In acute DSS-induced colitis nuclear factor (NF)-kappaB-dependent inflammatory cytokines including IL-1 and tumour necrosis factor-alpha (TNF-alpha) are up-regulated.	dss	9-12	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	29-55
10759764-1	2000	In acute DSS-induced colitis nuclear factor (NF)-kappaB-dependent inflammatory cytokines including IL-1 and tumour necrosis factor-alpha (TNF-alpha) are up-regulated.	dss	9-12	tumor necrosis factor	Mus musculus	138-147
10759764-6	2000	Furthermore, colonic NF-kappaB DNA-binding activity was increased in DSS-induced colitis and was suppressed by gliotoxin.	dss	69-72	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30
10759764-7	2000	These results demonstrate the essential role of NF-kappaB in DSS-induced colitis and indicate a molecular approach to the treatment of intestinal inflammatory disorders.	dss	61-64	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	48-57
10683376-4	2000	Both COX-1(-/-) and COX-2(-/-) mice showed increased susceptibility to a low-dose of DSS that caused mild colonic epithelial injury in wild-type mice.	dss	85-88	cytochrome c oxidase I, mitochondrial	Mus musculus	5-10
10683376-4	2000	Both COX-1(-/-) and COX-2(-/-) mice showed increased susceptibility to a low-dose of DSS that caused mild colonic epithelial injury in wild-type mice.	dss	85-88	cytochrome c oxidase II, mitochondrial	Mus musculus	20-25
10683376-7	2000	DSS treatment increased PGE(2) intestinal secretion in all groups except COX-2(-/-) mice.	dss	0-3	cytochrome c oxidase II, mitochondrial	Mus musculus	73-78
11196714-7	2000	We conclude that the main role of IL-5 in DSS-induced colonic inflammation is to attract a population of eosinophils which do not appear to contribute significantly to the initiation or development of tissue damage in this model of colitis.	dss	42-45	interleukin 5	Mus musculus	34-38
9844047-0	1998	Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines.	dss	65-68	negative elongation factor complex member C/D, Th1l	Mus musculus	90-93
10606964-2	2000	To determine its role in intestinal inflammation, we induced acute experimental colitis in mice with a deleted ICAM-1 gene, by feeding them with 3% dextran sodium sulphate (DSS) in drinking water for 7 days.	dss	173-176	intercellular adhesion molecule 1	Mus musculus	111-117
11070407-9	2000	Progressive upregulation in the transcripts for Th1 cytokines (IL-12, IFN-gamma, IL-1, TNF-alpha) was observed with increasing dosage of DSS.	dss	137-140	negative elongation factor complex member C/D, Th1l	Mus musculus	48-51
11070407-9	2000	Progressive upregulation in the transcripts for Th1 cytokines (IL-12, IFN-gamma, IL-1, TNF-alpha) was observed with increasing dosage of DSS.	dss	137-140	interferon gamma	Mus musculus	70-79
11070407-9	2000	Progressive upregulation in the transcripts for Th1 cytokines (IL-12, IFN-gamma, IL-1, TNF-alpha) was observed with increasing dosage of DSS.	dss	137-140	interleukin 1 complex	Mus musculus	63-67
11070407-9	2000	Progressive upregulation in the transcripts for Th1 cytokines (IL-12, IFN-gamma, IL-1, TNF-alpha) was observed with increasing dosage of DSS.	dss	137-140	tumor necrosis factor	Mus musculus	87-96
10469048-0	1999	Inhibition of dextran sulphate sodium (DSS)-induced colitis in mice by intracolonically administered antibodies against adhesion molecules (endothelial leucocyte adhesion molecule-1 (ELAM-1) or intercellular adhesion molecule-1 (ICAM-1)).	dss	39-42	selectin, endothelial cell	Mus musculus	140-181
10469048-4	1999	We concluded that adhesion molecule expression is important in the development of DSS-induced colitis in mice and that intracolonic administration of anti-adhesion molecule antibodies, especially anti-ELAM-1 antibody, effectively inhibits the colonic inflammation.	dss	82-85	selectin, endothelial cell	Mus musculus	201-207
10326706-8	1999	Factors predicting DSS were the UICC/AJCC TNM classification and regrouping into tumor stage (P = 0.002).	dss	19-22	teneurin transmembrane protein 1	Homo sapiens	42-45
10337013-0	1999	Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice.	dss	147-150	interferon gamma	Mus musculus	0-27
10337013-0	1999	Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice.	dss	147-150	tumor necrosis factor	Mus musculus	34-56
10337013-0	1999	Interferon-gamma (IFN-gamma)- and tumour necrosis factor (TNF)-induced nitric oxide as toxic effector molecule in chronic dextran sulphate sodium (DSS)-induced colitis in mice.	dss	147-150	tumor necrosis factor	Mus musculus	58-61
10337013-11	1999	TNF and IFN-gamma are involved in perpetuation of chronic DSS-induced colitis, and induction of excessive nitric oxide activity could be their common effector mechanism.	dss	58-61	tumor necrosis factor	Mus musculus	0-3
10337013-11	1999	TNF and IFN-gamma are involved in perpetuation of chronic DSS-induced colitis, and induction of excessive nitric oxide activity could be their common effector mechanism.	dss	58-61	interferon gamma	Mus musculus	8-17
10403604-15	1999	Despite impaired endothelium-dependent relaxation in renal and mesenteric vessels, HChol-Def DSS rats failed to develop hypertension (systolic blood pressure 144 +/- 1 in control and 150 +/- 2 mmHg in HChol-Def) but manifested a significant increase in sensitivity to the pressor effects of a high (2% NaCl) dietary salt content during the initial 10 weeks of the study, although the final blood pressure at 18 weeks was similar in both groups.	dss	93-96	UTP25 small subunit processome component	Rattus norvegicus	89-92
9844047-0	1998	Chronic experimental colitis induced by dextran sulphate sodium (DSS) is characterized by Th1 and Th2 cytokines.	dss	65-68	heart and neural crest derivatives expressed 2	Mus musculus	98-101
9844047-2	1998	The aim of our study was to evaluate if the chronic phase of DSS-induced colitis was characterized by a Th1/Th2 response and how this would relate to mucosal regeneration.	dss	61-64	negative elongation factor complex member C/D, Th1l	Mus musculus	104-107
9844047-2	1998	The aim of our study was to evaluate if the chronic phase of DSS-induced colitis was characterized by a Th1/Th2 response and how this would relate to mucosal regeneration.	dss	61-64	heart and neural crest derivatives expressed 2	Mus musculus	108-111
9844047-13	1998	Chronic DSS-induced colitis is characterized by focal epithelial regeneration and a Th1 as well as Th2 cytokine profile.	dss	8-11	negative elongation factor complex member C/D, Th1l	Mus musculus	84-87
9844047-13	1998	Chronic DSS-induced colitis is characterized by focal epithelial regeneration and a Th1 as well as Th2 cytokine profile.	dss	8-11	heart and neural crest derivatives expressed 2	Mus musculus	99-102
9794195-2	1998	We evaluated the effects of monoclonal antibodies to ICAM-1 on acute colitis induced by dextran sodium sulphate (DSS) in rats.	dss	113-116	intercellular adhesion molecule 1	Rattus norvegicus	53-59
9753490-7	1998	COX-1 was expressed in the crypt epithelium and lamina propria mononuclear cells; DSS treatment down-regulated COX-1 expression only in the epithelium.	dss	82-85	cytochrome c oxidase I, mitochondrial	Mus musculus	111-116
9753490-8	1998	Dimethyl PGE2 reversed the effect of DSS on COX-1 expression.	dss	37-40	cytochrome c oxidase I, mitochondrial	Mus musculus	44-49
9768537-10	1998	CONCLUSIONS: SASP and OLZ are able to ameliorate the DSS-induced intestinal inflammation.	dss	53-56	aspartic peptidase, retroviral-like 1	Mus musculus	13-17
9768537-4	1998	METHODS: DSS was used to induce intestinal inflammation in conventional Balb/c mice and athymic nu/nu CD-1(BR) mice, and the well-documented 5-aminosalicylic acid (5-ASA) based anticolitis drugs sulphasalazine (SASP) and olsalazine (OLZ) were used to study therapeutic effects.	dss	9-12	CD1 antigen complex	Mus musculus	102-110
9768537-4	1998	METHODS: DSS was used to induce intestinal inflammation in conventional Balb/c mice and athymic nu/nu CD-1(BR) mice, and the well-documented 5-aminosalicylic acid (5-ASA) based anticolitis drugs sulphasalazine (SASP) and olsalazine (OLZ) were used to study therapeutic effects.	dss	9-12	aspartic peptidase, retroviral-like 1	Mus musculus	211-215
9771407-1	1998	BACKGROUND: Transforming growth factor alpha (TGF-alpha) knockout mice have increased susceptibility to dextran sodium sulphate (DSS) induced colitis.	dss	129-132	transforming growth factor alpha	Mus musculus	12-44
9771407-1	1998	BACKGROUND: Transforming growth factor alpha (TGF-alpha) knockout mice have increased susceptibility to dextran sodium sulphate (DSS) induced colitis.	dss	129-132	transforming growth factor alpha	Mus musculus	46-55
9771407-2	1998	AIM: To substantiate the findings that TGF-alpha is a key mediator of colonic mucosal protection and/or repair mechanisms by evaluating the susceptibility of mice overexpressing TGF-alpha to DSS induced colitis.	dss	191-194	transforming growth factor alpha	Mus musculus	39-48
9771407-2	1998	AIM: To substantiate the findings that TGF-alpha is a key mediator of colonic mucosal protection and/or repair mechanisms by evaluating the susceptibility of mice overexpressing TGF-alpha to DSS induced colitis.	dss	191-194	transforming growth factor alpha	Mus musculus	178-187
9771407-9	1998	CONCLUSIONS: The significantly reduced susceptibility of mice overexpressing TGF-alpha to DSS further substantiates that endogenous TGF-alpha is a pivotal mediator of protection and/or healing mechanisms in the colon.	dss	90-93	transforming growth factor alpha	Mus musculus	77-86
9771407-9	1998	CONCLUSIONS: The significantly reduced susceptibility of mice overexpressing TGF-alpha to DSS further substantiates that endogenous TGF-alpha is a pivotal mediator of protection and/or healing mechanisms in the colon.	dss	90-93	transforming growth factor alpha	Mus musculus	132-141
9155534-11	1997	Human IFN-alpha alone caused minimal DNA damage (95% dss DNA), but increased 5-FU-induced effects to 35-50% dss DNA.	dss	53-56	interferon alpha 1	Homo sapiens	6-15
9360549-1	1997	The DAX-1 [DSS (dosage sensitive sex)-AHC critical region on the X, gene 1] gene is responsible for X-linked adrenal hypoplasia congenita (AHC).	dss	11-14	nuclear receptor subfamily 0 group B member 1	Homo sapiens	4-9
9396141-8	1997	Results demonstrate that enhanced colonic mucosal endothelial cell ICAM-1 expression is an early event in the inflammatory cascade of DSS-induced colitis.	dss	134-137	intercellular adhesion molecule 1	Rattus norvegicus	67-73
9287974-4	1997	TGF-alpha was also administered intraperitoneally to wa-1 mice to evaluate the effect of exogenous TGF-alpha in DSS colitis.	dss	112-115	transforming growth factor alpha	Mus musculus	99-108
9287974-8	1997	CONCLUSIONS: The marked susceptibility of TGF-alpha knockout and wa-1 mice to DSS and the obvious amelioration of the colonic injury by exogenous TGF-alpha application in wa-1 mice suggest that TGF-alpha is a mediator of protection and/or healing mechanisms in the colon.	dss	78-81	transforming growth factor alpha	Mus musculus	42-51
9636089-12	1998	DSs therefore may function to intermittently boost excitatory transmission in the entorhinal cortex-dentate gyrus-CA3 circuit.	dss	0-3	carbonic anhydrase 3	Rattus norvegicus	114-117
9357629-2	1997	The decision support system (DSS) used in this study was ILIAD (v4.2).	dss	29-32	immunoglobulin lambda variable 5-45	Homo sapiens	64-68
9014769-9	1996	Similarly, colonic tissue from DSS treated mice contained an increased amount of PLAP antigen compared with controls.	dss	31-34	phospholipase A2, activating protein	Mus musculus	81-85
9014769-10	1996	The stroma of the lamina propria of the colonic mucosa from the DSS treated mice reacted intensely with antibodies to PLAP synthetic peptides, while no reaction was observed with control mouse colons.	dss	64-67	phospholipase A2, activating protein	Mus musculus	118-122
9014769-11	1996	These data were supported by northern analysis which showed that PLAP mRNA was increased in the colons of DSS treated mice and cultured HT-29 cells exposed to LPS.	dss	106-109	phospholipase A2, activating protein	Mus musculus	65-69
8855822-1	1996	The DAX-1 [DSS (dosage-sensitive sex)-AHC critical region in the X, gene 1] gene has been reported to be responsible for X-linked adrenal hypoplasia congenita (AHC) and hypogonadotropic hypogonadism.	dss	11-14	nuclear receptor subfamily 0 group B member 1	Homo sapiens	4-9
8991862-7	1996	The expression of a large number of cell adhesion molecules expressed on intraepithelial lymphocytes is affected by a combination of the abundant gut cytokine TGF beta and DSS, suggesting that DSS induced colitis may ultimately arise from a combination of gut cytokine and DSS.	dss	193-196	transforming growth factor, beta 1	Mus musculus	159-167
8991862-7	1996	The expression of a large number of cell adhesion molecules expressed on intraepithelial lymphocytes is affected by a combination of the abundant gut cytokine TGF beta and DSS, suggesting that DSS induced colitis may ultimately arise from a combination of gut cytokine and DSS.	dss	193-196	transforming growth factor, beta 1	Mus musculus	159-167
9155534-11	1997	Human IFN-alpha alone caused minimal DNA damage (95% dss DNA), but increased 5-FU-induced effects to 35-50% dss DNA.	dss	108-111	interferon alpha 1	Homo sapiens	6-15
8791510-4	1996	The gene responsible for adrenal hypoplasia congenita, DAX1, is a candidate for the X-linked dosage sensitive sex reversal gene (DSS).	dss	129-132	nuclear receptor subfamily 0 group B member 1	Homo sapiens	55-59
8125632-4	1994	Realisation of the DSS is discussed in relation to client-server architecture and object-oriented databases, which are essential concepts of the HELIOS environment.	dss	19-22	IKAROS family zinc finger 2	Homo sapiens	145-151
8125632-3	1994	Architecture of a DSS based on Arden Syntax and its integration in the HELIOS environment are presented.	dss	18-21	IKAROS family zinc finger 2	Homo sapiens	71-77
8991862-3	1996	RESULTS: Integrin alpha 4 expression was marginally down regulated by 0.5% of DSS, while alpha M290 expression was up regulated.	dss	78-81	integrin alpha 4	Mus musculus	9-25
8625082-10	1995	CONCLUSIONS: Long term DSS is possible in a non-PSA screened series of men with poorly differentiated prostate cancer treated by radical prostatectomy.	dss	23-26	kallikrein related peptidase 3	Homo sapiens	48-51
2146368-3	1990	To detect B-50/CaM binding, we used the cross-linker disuccimidyl suberate (DSS) to form a covalent B-50/CaM complex, which is stable on SDS-PAGE.	dss	76-79	growth associated protein 43	Homo sapiens	10-14
1328376-11	1992	CONCLUSIONS: These results indicate that whereas the rise in blood pressure is dependent upon sodium loading, morbidity and mortality in salt-loaded DSS rats are associated with activation of the renin-angiotensin system and are only partially related to blood pressure.	dss	149-152	renin	Rattus norvegicus	196-201
2146368-3	1990	To detect B-50/CaM binding, we used the cross-linker disuccimidyl suberate (DSS) to form a covalent B-50/CaM complex, which is stable on SDS-PAGE.	dss	76-79	calmodulin 1	Homo sapiens	15-18
2146368-3	1990	To detect B-50/CaM binding, we used the cross-linker disuccimidyl suberate (DSS) to form a covalent B-50/CaM complex, which is stable on SDS-PAGE.	dss	76-79	growth associated protein 43	Homo sapiens	100-104
2146368-3	1990	To detect B-50/CaM binding, we used the cross-linker disuccimidyl suberate (DSS) to form a covalent B-50/CaM complex, which is stable on SDS-PAGE.	dss	76-79	calmodulin 1	Homo sapiens	105-108
2146368-4	1990	Upon addition of DSS, purified B-50 and calmodulin form a 70-kDa complex in the absence but not in the presence of Ca2+.	dss	17-20	growth associated protein 43	Homo sapiens	31-35
2146368-4	1990	Upon addition of DSS, purified B-50 and calmodulin form a 70-kDa complex in the absence but not in the presence of Ca2+.	dss	17-20	calmodulin 1	Homo sapiens	40-50
2146368-6	1990	DSS treatment of SPM or growth cone membranes with or without exogenous CaM results in the formation of a 70-kDa B-50/CAM complex detectable only in the absence of Ca2+ with both antibodies.	dss	0-3	calmodulin 1	Homo sapiens	72-75
2146368-6	1990	DSS treatment of SPM or growth cone membranes with or without exogenous CaM results in the formation of a 70-kDa B-50/CAM complex detectable only in the absence of Ca2+ with both antibodies.	dss	0-3	growth associated protein 43	Homo sapiens	113-117
2146368-6	1990	DSS treatment of SPM or growth cone membranes with or without exogenous CaM results in the formation of a 70-kDa B-50/CAM complex detectable only in the absence of Ca2+ with both antibodies.	dss	0-3	calmodulin 1	Homo sapiens	118-121
32796851-5	2020	Furthermore, Mbd3-/-Rag1-/- and circKcnt2-/-Rag1-/- mice develop severe innate colitis following dextran sodium sulfate (DSS) treatments, while simultaneous deletion of Batf promotes colitis resolution.	dss	121-124	methyl-CpG binding domain protein 3	Mus musculus	13-17
33941035-4	2021	Loss of function studies indicate that LINGO3 is involved in recovery of normal intestinal architecture following dextran sodium sulfate (DSS)-induced colitis, and that LINGO3 is needed for therapeutic action of the long acting TFF2 fusion protein (TFF2-Fc), including a number of signaling pathways critical for cell proliferation and wound repair.	dss	138-141	leucine rich repeat and Ig domain containing 3	Homo sapiens	39-45
32796851-5	2020	Furthermore, Mbd3-/-Rag1-/- and circKcnt2-/-Rag1-/- mice develop severe innate colitis following dextran sodium sulfate (DSS) treatments, while simultaneous deletion of Batf promotes colitis resolution.	dss	121-124	recombination activating 1	Mus musculus	44-48
26876164-6	2016	In univariate analysis, CSNK2A1 was a strong indicator of a poor overall survival (OS) (HR = 5.01, p &lt; 0.001), disease specific survival (DSS) (HR = 6.21, p = 0.007) and progression free survival (PFS) (HR = 5.93, p = 0.005).	dss	141-144	casein kinase 2 alpha 1	Homo sapiens	24-31
25765901-5	2015	The results indicated that TUSC7 was downregulated in GC samples and was an independent prognostic indicator of disease-free survival (DFS) and disease-specific survival (DSS) in GC patients.	dss	171-174	tumor suppressor candidate 7	Homo sapiens	27-32
33807999-0	2021	Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-kappaB Pathway.	dss	39-42	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	Mus musculus	8-13
33807999-0	2021	Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-kappaB Pathway.	dss	39-42	transformation related protein 53, pseudogene	Mus musculus	75-78
33807999-0	2021	Loss of Nckx3 Exacerbates Experimental DSS-Induced Colitis in Mice through p53/NF-kappaB Pathway.	dss	39-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	79-88
33807999-8	2021	Using dextran sodium sulfate (DSS)-induced experimental colitis mice models, the Nckx3 KO mice showed severe colitis.	dss	30-33	solute carrier family 24 (sodium/potassium/calcium exchanger), member 3	Mus musculus	81-86
24030525-0	2013	Chloride channel ClC-2 is a key factor in the development of DSS-induced murine colitis.	dss	61-64	chloride voltage-gated channel 2	Homo sapiens	17-22
24030525-3	2013	METHODS: The role of ClC-2 was investigated in TJ barrier function in dextran sodium sulfate (DSS)-induced colitis in ClC-2 knockout mice and ClC-2 knockdown intestinal Caco-2 cells.	dss	94-97	chloride channel, voltage-sensitive 2	Mus musculus	21-26
24030525-6	2013	RESULTS: ClC-2 mice had a higher disease activity index, higher histological scores, and increased paracellular permeability compared with wild-type mice when treated with DSS.	dss	172-175	chloride channel, voltage-sensitive 2	Mus musculus	9-14
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	chloride channel, voltage-sensitive 2	Mus musculus	12-17
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	claudin 2	Mus musculus	37-46
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	occludin	Mus musculus	75-83
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	occludin	Mus musculus	126-134
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	caveolin 1, caveolae protein	Mus musculus	140-150
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	tumor necrosis factor	Mus musculus	180-207
24030525-7	2013	DSS-treated ClC-2 mice had increased claudin-2 expression, greater loss of occludin in the membrane, increased association of occludin with caveolin-1, and significantly increased tumor necrosis factor-alpha and interleukin-1beta messenger RNA.	dss	0-3	interleukin 1 beta	Mus musculus	212-229
24030525-9	2013	The restoration of colonic barrier function after DSS colitis was delayed in ClC-2 mice.	dss	50-53	chloride channel, voltage-sensitive 2	Mus musculus	77-82
34874516-12	2022	CONCLUSION: HQD significantly relieved the symptoms in DSS-induced colitis mice by inhibiting pro-inflammatory cytokines expression and maintained the homeostasis of TJ protein in FHC cells by suppressing TNF-alpha-induced NF-kappaB activation.	dss	55-58	tumor necrosis factor	Mus musculus	205-214
34874516-12	2022	CONCLUSION: HQD significantly relieved the symptoms in DSS-induced colitis mice by inhibiting pro-inflammatory cytokines expression and maintained the homeostasis of TJ protein in FHC cells by suppressing TNF-alpha-induced NF-kappaB activation.	dss	55-58	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	223-232
34874516-0	2022	Huangqin Decoction Attenuates DSS-Induced Mucosal Damage and Promotes Epithelial Repair via Inhibiting TNF-alpha-Induced NF-kappaB Activation.	dss	30-33	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	121-130
34890974-8	2022	In vivo experiments suggested that Rh2 NPs significantly ameliorated the weight loss, colon length, disease activity index (DAI) score, and myeloperoxidase (MPO) activity in mice caused by dextran sulfate sodium salt (DSS) (p < 0.05).	dss	218-221	myeloperoxidase	Mus musculus	140-155
34890974-8	2022	In vivo experiments suggested that Rh2 NPs significantly ameliorated the weight loss, colon length, disease activity index (DAI) score, and myeloperoxidase (MPO) activity in mice caused by dextran sulfate sodium salt (DSS) (p < 0.05).	dss	218-221	myeloperoxidase	Mus musculus	157-160
34536451-7	2022	RESULTS: Deficiency of GPR120 in CD4+T cells resulted in more severe colitis in mice upon DSS insult and enteric infection.	dss	90-93	free fatty acid receptor 4	Mus musculus	23-29
34536451-7	2022	RESULTS: Deficiency of GPR120 in CD4+T cells resulted in more severe colitis in mice upon DSS insult and enteric infection.	dss	90-93	CD4 antigen	Mus musculus	33-36
34958000-6	2022	The patients with CRC whose tumors showed higher cytoplasmic expression of DCLK1-S had worse disease-specific survival (DSS) (log-rank test, P= 0.03) and 5-year DSS rates (P= 0.01).	dss	120-123	doublecortin like kinase 1	Homo sapiens	75-80
34958000-6	2022	The patients with CRC whose tumors showed higher cytoplasmic expression of DCLK1-S had worse disease-specific survival (DSS) (log-rank test, P= 0.03) and 5-year DSS rates (P= 0.01).	dss	161-164	doublecortin like kinase 1	Homo sapiens	75-80
34958000-8	2022	CONCLUSIONS: Our findings strongly supported that high cytoplasmic expression of DCLK1-S compared to its moderate expression could be considered an independent prognostic factor influencing DSS.	dss	190-193	doublecortin like kinase 1	Homo sapiens	81-86
34918781-5	2022	METHODS: A mild and chronic dextran sodium sulfate (DSS)-induced colitis mice model harboring LRRK2 G2019S mutation was established.	dss	52-55	leucine-rich repeat kinase 2	Mus musculus	94-99
34918781-7	2022	RESULTS: The LRRK2 G2019S mice are more vulnerable to DSS-induced colitis than littermate controls or LRRK2 WT animals with increased intestinal expressions of pattern-recognition receptors, including toll-like receptors (TLRs), nuclear factor (NF)-kappaB activation, and pro-inflammatory cytokines secretion, especially tumor necrosis factor (TNF)-alpha.	dss	54-57	leucine-rich repeat kinase 2	Mus musculus	13-18
34918781-7	2022	RESULTS: The LRRK2 G2019S mice are more vulnerable to DSS-induced colitis than littermate controls or LRRK2 WT animals with increased intestinal expressions of pattern-recognition receptors, including toll-like receptors (TLRs), nuclear factor (NF)-kappaB activation, and pro-inflammatory cytokines secretion, especially tumor necrosis factor (TNF)-alpha.	dss	54-57	tumor necrosis factor	Mus musculus	321-354
34944860-9	2021	Patients with pT3 pathology who received six cycles of adjuvant chemotherapy had better 5-year DSS (97.7%) than those with no chemotherapy (88.1%; p = 0.06) and those who underwent 1-3 cycles (86.9%, p = 0.02) or 4-5 cycles (89.3%, p = 0.06).	dss	95-98	zinc finger protein 135	Homo sapiens	14-17
34906411-9	2022	The FGFR3 mutation was associated with lower pT-stage (P<0.001), lower grade (P<0.001), pN0 (P=0.001) and prolonged DSS (P<0.001).	dss	116-119	fibroblast growth factor receptor 3	Homo sapiens	4-9
34959635-8	2021	Subsequent STW 5 treatment abolished both the macroscopic signs of gut inflammation, DSS-induced mucosecretory phenotype, and normalized the DSS-induced upregulated expression of il10 and Wnt signaling genes, such as wnt3a and cldn1 in explanted zebrafish gut.	dss	141-144	interleukin 10	Danio rerio	179-183
34494169-9	2022	Institutionally, factors associated with shorter DSS included advanced age, active cigarette smoker (p = 0.002), cT2 disease (p = 0.007), and MCC with unknown primary (p < 0.001).	dss	49-52	cancer/testis antigen 2	Homo sapiens	113-116
34783296-9	2021	DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-alpha), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon.	dss	0-3	tumor necrosis factor	Mus musculus	84-111
34783296-9	2021	DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-alpha), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon.	dss	0-3	tumor necrosis factor	Mus musculus	113-122
34783296-9	2021	DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-alpha), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon.	dss	0-3	interleukin 6	Mus musculus	125-139
34783296-9	2021	DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-alpha), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon.	dss	0-3	interleukin 6	Mus musculus	141-145
34783296-9	2021	DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-alpha), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon.	dss	0-3	myeloperoxidase	Mus musculus	151-166
34783296-9	2021	DSS promotes pathological injury, the levels of pro-inflammatory factors containing tumor necrosis factor alpha (TNF-alpha), Interleukin- 6 (IL-6) and myeloperoxidase (MPO), and cell apoptosis in the mouse colon.	dss	0-3	myeloperoxidase	Mus musculus	168-171
34961589-0	2021	Protective effect of Pai-Nong-San against AOM/DSS-induced CAC in mice through inhibiting the Wnt signaling pathway.	dss	46-49	serine (or cysteine) peptidase inhibitor, clade E, member 1	Mus musculus	21-24
34738626-11	2021	Disease-free survival (DFS) and disease-specific survival (DSS) were both significantly reduced in patients with low MMP-1 expression (log-rank test; DFS: P=0.005; DSS: P=0.022).	dss	59-62	matrix metallopeptidase 1	Homo sapiens	117-122
34738626-11	2021	Disease-free survival (DFS) and disease-specific survival (DSS) were both significantly reduced in patients with low MMP-1 expression (log-rank test; DFS: P=0.005; DSS: P=0.022).	dss	164-167	matrix metallopeptidase 1	Homo sapiens	117-122
34738626-12	2021	Multivariate analysis demonstrated that MMP-1 expression was an independent prognostic factor for DFS and DSS (DFS: HR=2.11 (1.22-3.92) P=0.005, DSS: HR=2.90 (1.23-8.50) P=0.012).	dss	106-109	matrix metallopeptidase 1	Homo sapiens	40-45
34738626-12	2021	Multivariate analysis demonstrated that MMP-1 expression was an independent prognostic factor for DFS and DSS (DFS: HR=2.11 (1.22-3.92) P=0.005, DSS: HR=2.90 (1.23-8.50) P=0.012).	dss	145-148	matrix metallopeptidase 1	Homo sapiens	40-45
34704372-4	2021	The mechanism was found to relate to 3HB cellular surface receptor GPR109a which can down-regulate NF-kappaB pathway, so as to decrease the percentage of M1 macrophages from 50% of dextran sulfate sodium salt (DSS) induced acute colitis mouse group to 42% DSS+3HB group mediating the inhibitory effect on the inflammation.	dss	210-213	hydroxycarboxylic acid receptor 2	Mus musculus	67-74
34704372-4	2021	The mechanism was found to relate to 3HB cellular surface receptor GPR109a which can down-regulate NF-kappaB pathway, so as to decrease the percentage of M1 macrophages from 50% of dextran sulfate sodium salt (DSS) induced acute colitis mouse group to 42% DSS+3HB group mediating the inhibitory effect on the inflammation.	dss	210-213	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
34704372-4	2021	The mechanism was found to relate to 3HB cellular surface receptor GPR109a which can down-regulate NF-kappaB pathway, so as to decrease the percentage of M1 macrophages from 50% of dextran sulfate sodium salt (DSS) induced acute colitis mouse group to 42% DSS+3HB group mediating the inhibitory effect on the inflammation.	dss	256-259	hydroxycarboxylic acid receptor 2	Mus musculus	67-74
34704372-4	2021	The mechanism was found to relate to 3HB cellular surface receptor GPR109a which can down-regulate NF-kappaB pathway, so as to decrease the percentage of M1 macrophages from 50% of dextran sulfate sodium salt (DSS) induced acute colitis mouse group to 42% DSS+3HB group mediating the inhibitory effect on the inflammation.	dss	256-259	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	99-108
34704372-5	2021	The activation of GPR109a was also found to inhibit colonic carcinogenesis, depended on reduced myeloid derived suppressor cells (MDSCs) accumulation from 27% of DSS group to 19% of DSS+3HB group.	dss	162-165	hydroxycarboxylic acid receptor 2	Mus musculus	18-25
34704372-5	2021	The activation of GPR109a was also found to inhibit colonic carcinogenesis, depended on reduced myeloid derived suppressor cells (MDSCs) accumulation from 27% of DSS group to 19% of DSS+3HB group.	dss	182-185	hydroxycarboxylic acid receptor 2	Mus musculus	18-25
34348563-14	2021	DISCUSSION AND CONCLUSIONS: These results indicate EDT attenuates DSS-induced colitis by activating the Shh pathway.	dss	66-69	sonic hedgehog	Mus musculus	104-107
34653399-7	2021	RESULTS: The levels of HSP-70 in the striatum and CA-3 region of the DSS rats were significantly higher than those of the control and non-DSS rats, whereas the dentate gyrus HSP-70 levels in both the DSS and non-DSS rats were increased versus the controls.	dss	69-72	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-29
34653399-7	2021	RESULTS: The levels of HSP-70 in the striatum and CA-3 region of the DSS rats were significantly higher than those of the control and non-DSS rats, whereas the dentate gyrus HSP-70 levels in both the DSS and non-DSS rats were increased versus the controls.	dss	69-72	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	174-180
34653399-7	2021	RESULTS: The levels of HSP-70 in the striatum and CA-3 region of the DSS rats were significantly higher than those of the control and non-DSS rats, whereas the dentate gyrus HSP-70 levels in both the DSS and non-DSS rats were increased versus the controls.	dss	138-141	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-29
34915801-10	2021	Furthermore, proinflammatory factor, interferon-gamma (IFN-gamma)+ from CD4+ T cells in DSS-induced NASH rats increased significantly (p < 0.01) compared to NC group.	dss	88-91	interferon gamma	Rattus norvegicus	37-53
34915801-10	2021	Furthermore, proinflammatory factor, interferon-gamma (IFN-gamma)+ from CD4+ T cells in DSS-induced NASH rats increased significantly (p < 0.01) compared to NC group.	dss	88-91	interferon gamma	Rattus norvegicus	55-64
34915801-10	2021	Furthermore, proinflammatory factor, interferon-gamma (IFN-gamma)+ from CD4+ T cells in DSS-induced NASH rats increased significantly (p < 0.01) compared to NC group.	dss	88-91	Cd4 molecule	Rattus norvegicus	72-75
34884678-11	2021	Results of this study suggest that LEP is a powerful prognosticator of OC recurrence and DSS.	dss	89-92	leptin	Homo sapiens	35-38
34959635-7	2021	KEY FINDINGS: DSS treatment up-regulated the expression of interleukin-8, tumor necrosis factor-alpha, wnt3a, and claudin-1 in explanted zebrafish gut.	dss	14-17	chemokine (C-X-C motif) ligand 8b, duplicate 1	Danio rerio	59-72
34959635-7	2021	KEY FINDINGS: DSS treatment up-regulated the expression of interleukin-8, tumor necrosis factor-alpha, wnt3a, and claudin-1 in explanted zebrafish gut.	dss	14-17	tumor necrosis factor a (TNF superfamily, member 2)	Danio rerio	74-101
34959635-7	2021	KEY FINDINGS: DSS treatment up-regulated the expression of interleukin-8, tumor necrosis factor-alpha, wnt3a, and claudin-1 in explanted zebrafish gut.	dss	14-17	wingless-type MMTV integration site family, member 3A	Danio rerio	103-108
34959635-7	2021	KEY FINDINGS: DSS treatment up-regulated the expression of interleukin-8, tumor necrosis factor-alpha, wnt3a, and claudin-1 in explanted zebrafish gut.	dss	14-17	claudin 1	Danio rerio	114-123
34900217-0	2021	Ethanol Extract of Pomegranate (Punica granatum) Peel in Increasing the Expression of Caspase-3 in DSS-Induced Mice.	dss	99-102	caspase 3	Homo sapiens	86-95
34900217-4	2021	This study examined the effects of the pomegranate peel extract on the expression of caspase-3 in mice crypt cells induced by dextran sodium sulfate (DSS) 2%.	dss	150-153	caspase 3	Homo sapiens	85-94
34365557-7	2021	Additionally, CHC levels in the EAC patients correlated with residual nodal involvement (P = 0.026) and 1-year DSS (P = 0.029).	dss	111-114	clathrin heavy chain	Homo sapiens	14-17
34526359-11	2021	Moreover, our in-silico DSS showed that not only t(11;14) but also chr(1q)gain/amps and CYLD inactivation predicted differential expression of transcripts of the BCL2-axis and response to venetoclax.	dss	24-27	CYLD lysine 63 deubiquitinase	Homo sapiens	88-92
34526359-11	2021	Moreover, our in-silico DSS showed that not only t(11;14) but also chr(1q)gain/amps and CYLD inactivation predicted differential expression of transcripts of the BCL2-axis and response to venetoclax.	dss	24-27	BCL2 apoptosis regulator	Homo sapiens	162-166
34775365-0	2021	MicroRNA-497 inhibits inflammation in DSS-induced IBD model mice and lipopolysaccharide-induced RAW264.7 cells via Wnt/beta-catenin pathway.	dss	38-41	microRNA 497	Mus musculus	0-12
34775365-8	2021	miR-497 knockout (miR-497 KO) mice were more susceptible to DSS-induced colitis, with increased inflammatory response, compared with control mice.	dss	60-63	microRNA 497	Mus musculus	0-7
34775365-8	2021	miR-497 knockout (miR-497 KO) mice were more susceptible to DSS-induced colitis, with increased inflammatory response, compared with control mice.	dss	60-63	microRNA 497	Mus musculus	18-25
34775365-11	2021	CONCLUSION: Our data indicate that miR-497 inhibits inflammation in DSS-induced IBD model mice and LPS-induced RAW264.7 cells by inhibiting the activation of NF-kappaB pathway and the release of cytokines, indicating that miR-497 plays a key role in the progression of IBD.	dss	68-71	microRNA 497	Mus musculus	35-42
34775365-11	2021	CONCLUSION: Our data indicate that miR-497 inhibits inflammation in DSS-induced IBD model mice and LPS-induced RAW264.7 cells by inhibiting the activation of NF-kappaB pathway and the release of cytokines, indicating that miR-497 plays a key role in the progression of IBD.	dss	68-71	microRNA 497	Mus musculus	222-229
34653399-7	2021	RESULTS: The levels of HSP-70 in the striatum and CA-3 region of the DSS rats were significantly higher than those of the control and non-DSS rats, whereas the dentate gyrus HSP-70 levels in both the DSS and non-DSS rats were increased versus the controls.	dss	200-203	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-29
34653399-7	2021	RESULTS: The levels of HSP-70 in the striatum and CA-3 region of the DSS rats were significantly higher than those of the control and non-DSS rats, whereas the dentate gyrus HSP-70 levels in both the DSS and non-DSS rats were increased versus the controls.	dss	200-203	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	174-180
34653399-7	2021	RESULTS: The levels of HSP-70 in the striatum and CA-3 region of the DSS rats were significantly higher than those of the control and non-DSS rats, whereas the dentate gyrus HSP-70 levels in both the DSS and non-DSS rats were increased versus the controls.	dss	212-215	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	23-29
34653399-7	2021	RESULTS: The levels of HSP-70 in the striatum and CA-3 region of the DSS rats were significantly higher than those of the control and non-DSS rats, whereas the dentate gyrus HSP-70 levels in both the DSS and non-DSS rats were increased versus the controls.	dss	212-215	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	174-180
34653399-8	2021	The levels of GLT-1/GS in the CA-3 and nucleus accumbens were increased in the DSS rats.	dss	79-82	solute carrier family 1 member 2	Rattus norvegicus	14-22
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	44-47	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	138-144
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	44-47	solute carrier family 1 member 2	Rattus norvegicus	153-158
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	44-47	glutamate-ammonia ligase	Rattus norvegicus	159-161
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	44-47	carbonic anhydrase 3	Rattus norvegicus	176-179
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	218-221	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	138-144
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	218-221	solute carrier family 1 member 2	Rattus norvegicus	153-158
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	218-221	glutamate-ammonia ligase	Rattus norvegicus	159-161
34653399-9	2021	CONCLUSIONS: These results suggest that the DSS rats experienced striatal neuronal damage and indicate that a HAL-induced upregulation of HSP-70 and the GLT-1/GS system in the CA3 may be involved in the development of DSS.	dss	218-221	carbonic anhydrase 3	Rattus norvegicus	176-179
34885098-8	2021	The combination of intratumoral CLEVER-1+ lymphatic vesselhigh + CD68+ TAMlow was associated with poor DSS in stage I-IV rectal cancer.	dss	103-106	stabilin 1	Homo sapiens	32-40
34868397-10	2021	Accordingly, the time-independent receiver operating characteristic (ROC) curve confirmed that PITX1 had good predictive efficacy for OS and DSS.	dss	141-144	paired like homeodomain 1	Homo sapiens	95-100
34959635-8	2021	Subsequent STW 5 treatment abolished both the macroscopic signs of gut inflammation, DSS-induced mucosecretory phenotype, and normalized the DSS-induced upregulated expression of il10 and Wnt signaling genes, such as wnt3a and cldn1 in explanted zebrafish gut.	dss	141-144	wingless-type MMTV integration site family, member 3A	Danio rerio	188-191
34959635-8	2021	Subsequent STW 5 treatment abolished both the macroscopic signs of gut inflammation, DSS-induced mucosecretory phenotype, and normalized the DSS-induced upregulated expression of il10 and Wnt signaling genes, such as wnt3a and cldn1 in explanted zebrafish gut.	dss	141-144	wingless-type MMTV integration site family, member 3A	Danio rerio	217-222
34829479-5	2021	After uni- and multi-variable analysis of five-year survival, MLPH expression was still associated with lower DSS (hazard ratio (HR), 10.110; 95% confidence interval (CI), 2.178-46.920; p = 0.003) and MeFS (HR, 5.621; 95% CI, 1.762-17.931; p = 0.004).	dss	110-113	melanophilin	Homo sapiens	62-66
34959635-8	2021	Subsequent STW 5 treatment abolished both the macroscopic signs of gut inflammation, DSS-induced mucosecretory phenotype, and normalized the DSS-induced upregulated expression of il10 and Wnt signaling genes, such as wnt3a and cldn1 in explanted zebrafish gut.	dss	141-144	claudin 1	Danio rerio	227-232
34743196-2	2021	Here, we showed that Downstream of Kinase 3 (DOK3), an adapter protein involved in immune signaling, confers protection of mice from dextran sodium sulfate (DSS)-induced colitis.	dss	157-160	docking protein 3	Mus musculus	21-43
34758843-0	2021	DSS-induced inflammation in the colon drives a proinflammatory signature in the brain that is ameliorated by prophylactic treatment with the S100A9 inhibitor paquinimod.	dss	0-3	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	141-147
34867387-9	2021	As a result, DSS induced experimental colitis, and this induction was alleviated by GCZX treatment, as evidenced by rescued pathological symptoms in UC mouse models, such as rectal bleeding stopping, decreased levels of albumin, interleukin-17, as well as chemokine (C-X-C motif) ligand 1 (CXCL1), and reduction in colon length.	dss	13-16	albumin	Mus musculus	220-227
34867387-9	2021	As a result, DSS induced experimental colitis, and this induction was alleviated by GCZX treatment, as evidenced by rescued pathological symptoms in UC mouse models, such as rectal bleeding stopping, decreased levels of albumin, interleukin-17, as well as chemokine (C-X-C motif) ligand 1 (CXCL1), and reduction in colon length.	dss	13-16	chemokine (C-X-C motif) ligand 1	Mus musculus	256-288
34867387-9	2021	As a result, DSS induced experimental colitis, and this induction was alleviated by GCZX treatment, as evidenced by rescued pathological symptoms in UC mouse models, such as rectal bleeding stopping, decreased levels of albumin, interleukin-17, as well as chemokine (C-X-C motif) ligand 1 (CXCL1), and reduction in colon length.	dss	13-16	chemokine (C-X-C motif) ligand 1	Mus musculus	290-295
34767810-3	2022	Using adoptive bone marrow transfer from CX3CR1-EGFP+ reporter mice and high-resolution confocal microscopy, we assessed the time course of CX3CR1+ cell repopulation of steady-state and dextran sodium sulfate (DSS)-inflamed small intestine/colon and the brain over four weeks post-irradiation.	dss	210-213	C-X3-C motif chemokine receptor 1	Homo sapiens	140-146
34767810-9	2022	Early increases of TMEM119 and Iba1 expression within the brain following DSS-induced colon injury suggest immune priming effect of the brain resident microglia in response to systemic inflammation.	dss	74-77	transmembrane protein 119	Homo sapiens	19-26
34767810-9	2022	Early increases of TMEM119 and Iba1 expression within the brain following DSS-induced colon injury suggest immune priming effect of the brain resident microglia in response to systemic inflammation.	dss	74-77	allograft inflammatory factor 1	Homo sapiens	31-35
34743196-2	2021	Here, we showed that Downstream of Kinase 3 (DOK3), an adapter protein involved in immune signaling, confers protection of mice from dextran sodium sulfate (DSS)-induced colitis.	dss	157-160	docking protein 3	Mus musculus	45-49
34765317-6	2021	Patients with CD24-high tumors have significantly better DSS (P<0.001) and OS (P = 0.043).	dss	57-60	CD24 molecule	Homo sapiens	14-18
34891643-3	2021	At the University of Padova, we are developing a new DSS that currently integrate a smart insulin bolus calculator for optimal insulin dosing and a rescue carbohydrate intake advisor to tackle hypoglycemia.	dss	53-56	insulin	Homo sapiens	90-97
34804049-0	2021	Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-kappaB Activation in Neutrophils.	dss	51-54	inhibitor of DNA binding 2	Mus musculus	0-30
34804049-0	2021	Inhibitor of Differentiation-2 Protein Ameliorates DSS-Induced Ulcerative Colitis by Inhibiting NF-kappaB Activation in Neutrophils.	dss	51-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	96-105
34804049-3	2021	Firstly, we confirmed that the expression of ID2 was reduced in the colon tissues of DSS-induced colitis mice and patients with ulcerative colitis (UC).	dss	85-88	inhibitor of DNA binding 2	Mus musculus	45-48
34804049-5	2021	After purification and identification, purified hID2 could ameliorate DSS-induced colitis efficiently in mice by improving disease symptoms, decreasing the levels of proinflammatory cytokines in colon tissues, maintaining the integrity of intestinal barrier and reducing the infiltration of neutrophils and macrophages in the colon.	dss	70-73	inhibitor of DNA binding 2	Homo sapiens	48-52
34644426-2	2021	However, how SJW alleviates dextran sodium sulfate (DSS)-induced experimental IBD by activating PXR is unknown.	dss	52-55	nuclear receptor subfamily 1, group I, member 2	Mus musculus	96-99
34744741-4	2021	The results showed that 50 mg/kg SPS-1, an active fraction isolated from SPS, could significantly inhibit CRC induced by AOM/DSS and changed the polarization of macrophages to the M1 phenotype.	dss	125-128	selenophosphate synthetase 1	Mus musculus	33-38
34744741-5	2021	Meanwhile, SPS-1 treatment significantly alleviated the characteristic AOM/DSS-induced pathological symptoms, in terms of decreasing the nucleoplasmic ratio, nuclear polarity extinction, and gland hyperplasia.	dss	75-78	selenophosphate synthetase 1	Mus musculus	11-16
34765317-9	2021	There was no survival difference linked to CD133-high/CD44-low patients, but CD44-high/CD24-low patients have worse DSS (P = 0.005) compared with CD44-low/CD24-high patients.	dss	116-119	CD44 molecule (Indian blood group)	Homo sapiens	77-81
34765317-9	2021	There was no survival difference linked to CD133-high/CD44-low patients, but CD44-high/CD24-low patients have worse DSS (P = 0.005) compared with CD44-low/CD24-high patients.	dss	116-119	CD24 molecule	Homo sapiens	87-91
34611254-6	2021	Among the PNI/LVI double negative, single positive to double positive subgroups, increasing LN+, DM rates and decreasing DSS rate were observed.	dss	121-124	serpin family E member 2	Homo sapiens	10-17
34681015-8	2021	Here, we developed a completely non-invasive screening system using dried saliva spots (DSS) as an alternative DNA source to detect SMN1 deletion.	dss	88-91	survival of motor neuron 1, telomeric	Homo sapiens	132-136
34790760-12	2021	Furthermore, for DSS, increased expression of YTHDC2 was also correlated with better clinical outcomes (P<0.05).	dss	17-20	YTH domain containing 2	Homo sapiens	46-52
34087411-9	2021	In addition, FMD application reversed DSS-mediated reduction in intestinal stem cell marker Lgr5, while the cell proliferation markers Ki67 and PCNA were increased by FMD.	dss	38-41	leucine rich repeat containing G protein coupled receptor 5	Mus musculus	92-96
34550272-7	2021	Cox regression analyses showed that CXCL14, SLC44A1, and UBD were significantly associated with DSS, and PPP2R2C and SLC44A1 were associated with PFS.	dss	96-99	C-X-C motif chemokine ligand 14	Homo sapiens	36-42
34550272-7	2021	Cox regression analyses showed that CXCL14, SLC44A1, and UBD were significantly associated with DSS, and PPP2R2C and SLC44A1 were associated with PFS.	dss	96-99	solute carrier family 44 member 1	Homo sapiens	44-51
34589439-12	2021	Additionally, multivariate analysis demonstrated increased PDK3 expression is a significant predictive risk factor for DSS (hazard ratio (HR) in UBUC, 2.79, P = 0.009; in UTUC, 2.561, P = 0.03) and MFS (HR in UBUC, 1.907, P = 0.024; in UTUC, 1.793, P = 0.044).	dss	119-122	pyruvate dehydrogenase kinase 3	Homo sapiens	59-63
34474671-9	2021	A high (> 20%) tumoral PD-L1 positivity was associated with a better DFS and DSS.	dss	77-80	CD274 molecule	Homo sapiens	23-28
34216713-9	2021	Exposure to BaP/DSS also significantly elevated TNF-alpha levels, and the administration of 5-DMNB reversed this increase.	dss	16-19	tumor necrosis factor	Mus musculus	48-57
34331468-5	2021	DSS mediated inflammation in colons of rats with a significant increase in nitric oxide, myeloperoxidase, IL-1beta, IL-6, and TNF-alpha levels compared with a control group.	dss	0-3	myeloperoxidase	Rattus norvegicus	89-104
34331468-5	2021	DSS mediated inflammation in colons of rats with a significant increase in nitric oxide, myeloperoxidase, IL-1beta, IL-6, and TNF-alpha levels compared with a control group.	dss	0-3	interleukin 1 alpha	Rattus norvegicus	106-114
34331468-5	2021	DSS mediated inflammation in colons of rats with a significant increase in nitric oxide, myeloperoxidase, IL-1beta, IL-6, and TNF-alpha levels compared with a control group.	dss	0-3	interleukin 6	Rattus norvegicus	116-120
34331468-5	2021	DSS mediated inflammation in colons of rats with a significant increase in nitric oxide, myeloperoxidase, IL-1beta, IL-6, and TNF-alpha levels compared with a control group.	dss	0-3	tumor necrosis factor	Rattus norvegicus	126-135
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	27-30	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	27-30	interleukin 6	Homo sapiens	67-71
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	27-30	interleukin 17A	Homo sapiens	73-78
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	27-30	tumor necrosis factor	Homo sapiens	84-93
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	27-30	interleukin 4	Homo sapiens	195-199
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	27-30	interleukin 10	Homo sapiens	204-209
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	101-104	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	101-104	interleukin 6	Homo sapiens	67-71
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	101-104	interleukin 17A	Homo sapiens	73-78
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	101-104	tumor necrosis factor	Homo sapiens	84-93
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	101-104	interleukin 4	Homo sapiens	195-199
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	101-104	interleukin 10	Homo sapiens	204-209
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	113-116	interleukin 1 alpha	Homo sapiens	57-65
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	113-116	interleukin 6	Homo sapiens	67-71
34706861-9	2021	cMYC/BCL2 double-expressor DLBCLs had a poorer DSS than non-double-expressor DLBCLs (5-year DSS, 25% vs 78%) (HR 0.23; 95% CI 0.06 to 0.85; p=0.014).	dss	47-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
34706861-9	2021	cMYC/BCL2 double-expressor DLBCLs had a poorer DSS than non-double-expressor DLBCLs (5-year DSS, 25% vs 78%) (HR 0.23; 95% CI 0.06 to 0.85; p=0.014).	dss	47-50	BCL2 apoptosis regulator	Homo sapiens	5-9
34706861-9	2021	cMYC/BCL2 double-expressor DLBCLs had a poorer DSS than non-double-expressor DLBCLs (5-year DSS, 25% vs 78%) (HR 0.23; 95% CI 0.06 to 0.85; p=0.014).	dss	92-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
34706861-9	2021	cMYC/BCL2 double-expressor DLBCLs had a poorer DSS than non-double-expressor DLBCLs (5-year DSS, 25% vs 78%) (HR 0.23; 95% CI 0.06 to 0.85; p=0.014).	dss	92-95	BCL2 apoptosis regulator	Homo sapiens	5-9
34116185-15	2021	AFE treatment could also reduce the levels of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and increase the levels of interleukin-4 and interleukin-10 in colon tissues and serum of DSS-induced UC mice.	dss	202-205	interleukin 4	Mus musculus	139-152
34116185-15	2021	AFE treatment could also reduce the levels of tumor necrosis factor-alpha, interleukin-1beta, and interleukin-6 and increase the levels of interleukin-4 and interleukin-10 in colon tissues and serum of DSS-induced UC mice.	dss	202-205	interleukin 10	Mus musculus	157-171
34298397-3	2021	In this study, we report that IF1 gene inactivation generated protection against IBD in the dextran sodium sulfate (DSS) model.	dss	116-119	NDV-induced circulating interferon	Mus musculus	30-33
34390195-8	2021	Blockage of SIGNR1 abolished KMOS-induced AAM/M2 polarization of activated macrophages, expression of phospho-p65 (S276) in colonic macrophages, and alleviation of DSS-induced colitis in mice, suggesting that SIGNR1 is critical for macrophage responses to KMOS.	dss	164-167	CD209b antigen	Mus musculus	209-215
34593596-13	2022	Conclusion: 18F-FLT PET may serve as prognostic baseline imaging biomarker for DSS in patients with primary STS.	dss	79-82	fms related receptor tyrosine kinase 1	Homo sapiens	16-19
34543287-10	2021	Importantly, DSS colitis markedly decreased BDNF in both myocardium and serum.	dss	13-16	brain-derived neurotrophic factor	Rattus norvegicus	44-48
34543287-14	2021	Furthermore, IL-1beta neutralizing antibody ameliorated the DSS-induced increase in miR-155 and concurrent decrease in BDNF in the adult heart, showing therapeutic potential.	dss	60-63	interleukin 1 alpha	Rattus norvegicus	13-21
34543287-14	2021	Furthermore, IL-1beta neutralizing antibody ameliorated the DSS-induced increase in miR-155 and concurrent decrease in BDNF in the adult heart, showing therapeutic potential.	dss	60-63	microRNA 155	Rattus norvegicus	84-91
34543287-14	2021	Furthermore, IL-1beta neutralizing antibody ameliorated the DSS-induced increase in miR-155 and concurrent decrease in BDNF in the adult heart, showing therapeutic potential.	dss	60-63	brain-derived neurotrophic factor	Rattus norvegicus	119-123
34539183-9	2021	The high expression of ADCY7 in OS, DSS, and PFI was strongly associated with poor outcomes in patients with breast cancer and lung squamous cell carcinoma.	dss	36-39	adenylate cyclase 7	Homo sapiens	23-28
34273909-7	2021	Tumor-associated proteins, including p65 and Ki-67, were downregulated by the IRAK1/4 inhibitor in AOM/DSS-treated mice.	dss	103-106	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	37-40
34273909-7	2021	Tumor-associated proteins, including p65 and Ki-67, were downregulated by the IRAK1/4 inhibitor in AOM/DSS-treated mice.	dss	103-106	antigen identified by monoclonal antibody Ki 67	Mus musculus	45-50
34273909-7	2021	Tumor-associated proteins, including p65 and Ki-67, were downregulated by the IRAK1/4 inhibitor in AOM/DSS-treated mice.	dss	103-106	interleukin-1 receptor-associated kinase 1	Mus musculus	78-85
34761603-6	2021	Multivariate analysis confirmed that low HOXD10 expression was an independent predictor of shorter RFS (hazard ratio 1.873, p=0.006) and DSS (hazard ratio2.504, p=0.012) than high HOXD10 expression.	dss	137-140	homeobox D10	Homo sapiens	41-47
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	113-116	interleukin 17A	Homo sapiens	73-78
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	113-116	tumor necrosis factor	Homo sapiens	84-93
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	113-116	interleukin 4	Homo sapiens	195-199
34259316-8	2021	Compared with those in the DSS group, the expressions of IL-1beta, IL-6, IL-17, and TNF-alpha in the DSS+DHA and DSS+5-aminosalicylic acid (5-ASA) groups were decreased, while the expressions of IL-4 and IL-10 were significantly upregulated.	dss	113-116	interleukin 10	Homo sapiens	204-209
34611254-7	2021	Among the 44 LN+ patients, PNI/LVI double positive remained associated with a markedly high DM rate of 42.9% and a poor 5-year DSS of 27.7%.	dss	127-130	serpin family E member 2	Homo sapiens	27-34
34611254-8	2021	PNI/LVI double positive plays important roles in prognostication and potential clinical application for T3-4 OSCC by independently predicting LN+, DM, and poor DSS, and can be used as a good marker to select DM high-risk patients for novel adjuvant therapy trials.	dss	160-163	serpin family E member 2	Homo sapiens	0-7
34461859-9	2021	However, multivariate analysis revealed that infiltration of CD1a+ DCs was an independent unfavorable prognostic factor for both DSS (P = 0.009) and OS (P = 0.013).	dss	129-132	CD1a molecule	Homo sapiens	61-65
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	146-149	Janus kinase 2	Homo sapiens	98-102
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	146-149	signal transducer and activator of transcription 3	Homo sapiens	104-109
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	146-149	Janus kinase 2	Homo sapiens	113-117
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	146-149	signal transducer and activator of transcription 3	Homo sapiens	125-130
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	202-205	Janus kinase 2	Homo sapiens	98-102
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	202-205	signal transducer and activator of transcription 3	Homo sapiens	104-109
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	202-205	Janus kinase 2	Homo sapiens	113-117
34259316-10	2021	Western blot analysis and/or immunohistochemical staining analysis showed that the expressions of JAK2, STAT3, p-JAK2, and p-STAT3 in DSS+DHA and DSS+5-ASA groups were significantly lower than those in DSS group.	dss	202-205	signal transducer and activator of transcription 3	Homo sapiens	125-130
34409042-7	2021	Moreover, CLDN6 high expression can lead to a worse overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) in UCEC, especially in different clinical subgroups of UCEC.	dss	102-105	claudin 6	Homo sapiens	10-15
34456904-0	2021	Therapeutic Targeting of Nrf2 Signaling by Maggot Extracts Ameliorates Inflammation-Associated Intestinal Fibrosis in Chronic DSS-Induced Colitis.	dss	126-129	NFE2 like bZIP transcription factor 2	Homo sapiens	25-29
34584854-6	2021	In a multivariate analysis, intratumoral and intrastromal CD103+ lymphocytes and pathological T and N factors were independent prognostic factors of the DSS.	dss	153-156	integrin subunit alpha E	Homo sapiens	58-63
34133236-5	2021	Studies in genetically engineered mice showed that in comparison to Glut5+/+ mice, feeding a 15 kcal% fructose diet to Glut5-/- mice led to worse dextran sodium sulfate (DSS)-induced colitis.	dss	170-173	solute carrier family 2 (facilitated glucose transporter), member 5	Mus musculus	119-124
34062371-0	2021	A20 functions as a negative regulator in macrophage for DSS-induced colitis.	dss	56-59	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
34062371-1	2021	The function of A20 as a deubiquitinating enzyme in inflammatory diseases and autoimmune diseases has been reported, we therefore aimed to investigate the potential effects of A20 in macrophages and dextran sodium sulfate (DSS)-induced colitis mouse model.	dss	223-226	tumor necrosis factor, alpha-induced protein 3	Mus musculus	16-19
34062371-8	2021	A20 deficiency in macrophages led to severe symptoms of DSS-induced colitis in mice.	dss	56-59	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
34062371-10	2021	The effects of A20 deficiency in DSS-induced colitis were suppressed by NF-kappaB pathway inhibition.	dss	33-36	tumor necrosis factor, alpha-induced protein 3	Mus musculus	15-18
34062371-11	2021	A20/inhibitor of NF-kappaB kinase 2 (IKKbeta)-double knockout mice were resistant to DSS-induced colitis.	dss	85-88	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
34062371-11	2021	A20/inhibitor of NF-kappaB kinase 2 (IKKbeta)-double knockout mice were resistant to DSS-induced colitis.	dss	85-88	conserved helix-loop-helix ubiquitous kinase	Mus musculus	37-44
34062371-12	2021	A20 suppresses pro-inflammatory cytokine expression in macrophages through the NF-kappaB signal pathway and alleviates the pathogenesis of DSS-induced colitis in mice.	dss	139-142	tumor necrosis factor, alpha-induced protein 3	Mus musculus	0-3
34360835-9	2021	Moreover, the BB1 caused a marked enhancement in mouse intestinal TJ barrier in a TLR-2-dependent manner and protected against dextran sodium sulfate (DSS)-induced increase in mouse colonic permeability, and treated the DSS-induced colitis in a TJ barrier-dependent manner.	dss	151-154	Bb1	Mus musculus	14-17
34360835-9	2021	Moreover, the BB1 caused a marked enhancement in mouse intestinal TJ barrier in a TLR-2-dependent manner and protected against dextran sodium sulfate (DSS)-induced increase in mouse colonic permeability, and treated the DSS-induced colitis in a TJ barrier-dependent manner.	dss	220-223	Bb1	Mus musculus	14-17
34308487-2	2021	METHODS: A total of 274 consecutive patients who underwent TUS (by different examiners and with different ultrasound machines) and surgery, with suspicious OMs and known CA-125 serum level were used to train and test a DSS.	dss	219-222	mucin 16, cell surface associated	Homo sapiens	170-176
34359585-4	2021	Whole transcriptome profiling of normal colon was then performed, and gene set enrichment analysis (GSEA) revealed enriched fatty acid metabolism, oxidative phosphorylation, and PI3K-Akt-mTOR signaling in the tissues from DSS/AOM mice.	dss	222-225	thymoma viral proto-oncogene 1	Mus musculus	183-186
34359585-4	2021	Whole transcriptome profiling of normal colon was then performed, and gene set enrichment analysis (GSEA) revealed enriched fatty acid metabolism, oxidative phosphorylation, and PI3K-Akt-mTOR signaling in the tissues from DSS/AOM mice.	dss	222-225	mechanistic target of rapamycin kinase	Mus musculus	187-191
34359585-5	2021	Additionally, immunohistochemical staining showed increased expression levels of phosphorylated S6 ribosomal protein, a downstream target of the PI3K-Akt-mTOR pathway in the inflamed mucosa of DSS/AOM mice.	dss	193-196	thymoma viral proto-oncogene 1	Mus musculus	150-153
34359585-5	2021	Additionally, immunohistochemical staining showed increased expression levels of phosphorylated S6 ribosomal protein, a downstream target of the PI3K-Akt-mTOR pathway in the inflamed mucosa of DSS/AOM mice.	dss	193-196	mechanistic target of rapamycin kinase	Mus musculus	154-158
34359585-9	2021	This study provides additional insights into alterations associated with DSS/AOM-induced colitis and associates PI3K-Akt-mTOR, sphingolipid-signaling and lipoarabinomannan biosynthetic pathways in mouse DSS/AOM-induced colitis.	dss	73-76	mechanistic target of rapamycin kinase	Mus musculus	121-125
34359585-9	2021	This study provides additional insights into alterations associated with DSS/AOM-induced colitis and associates PI3K-Akt-mTOR, sphingolipid-signaling and lipoarabinomannan biosynthetic pathways in mouse DSS/AOM-induced colitis.	dss	203-206	mechanistic target of rapamycin kinase	Mus musculus	121-125
34359965-10	2021	In contrast, negative GP88 staining in ICs was an independent negative predictor for overall survival (OS) (RR = 2.18; p < 0.001), DSS (RR = 2.84; p < 0.001) and RFS (RR = 2.91; p < 0.001) in multivariate Cox"s regression analysis.	dss	131-134	granulin precursor	Homo sapiens	22-26
34272410-7	2021	Comp23 treatment attenuated the ex vivo permeability of colonic sacs, the clinical symptoms, and mucosal expression of Tgfb1, Il1b, Il6 and Il10 of DSS-treated mice.	dss	148-151	transforming growth factor, beta 1	Mus musculus	119-124
34272410-7	2021	Comp23 treatment attenuated the ex vivo permeability of colonic sacs, the clinical symptoms, and mucosal expression of Tgfb1, Il1b, Il6 and Il10 of DSS-treated mice.	dss	148-151	interleukin 1 beta	Mus musculus	126-130
34272410-7	2021	Comp23 treatment attenuated the ex vivo permeability of colonic sacs, the clinical symptoms, and mucosal expression of Tgfb1, Il1b, Il6 and Il10 of DSS-treated mice.	dss	148-151	interleukin 6	Mus musculus	132-135
34272410-7	2021	Comp23 treatment attenuated the ex vivo permeability of colonic sacs, the clinical symptoms, and mucosal expression of Tgfb1, Il1b, Il6 and Il10 of DSS-treated mice.	dss	148-151	interleukin 10	Mus musculus	140-144
34307147-0	2021	The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer.	dss	100-103	CD274 antigen	Mus musculus	46-51
34307147-0	2021	The Enhanced Inhibitory Effect of Estrogen on PD-L1 Expression Following Nrf2 Deficiency in the AOM/DSS Model of Colitis-Associated Cancer.	dss	100-103	nuclear factor, erythroid derived 2, like 2	Mus musculus	73-77
34307147-2	2021	We previously reported that Nrf2 deficiency enhances the anti-tumorigenic effect of 17beta-estradiol (E2) in an azoxymethane (AOM)/dextran sodium sulfate (DSS) model of colitis-associated cancer (CAC).	dss	155-158	nuclear factor, erythroid derived 2, like 2	Mus musculus	28-32
34307147-6	2021	Based on Western blotting results, PD-L1 expression was reduced in Nrf2 knockout (KO) female and E2-treated male mice when compared with their wild-type counterparts, following AOM/DSS treatment; this supports the association of PD-L1 expression with tumor progression.	dss	181-184	CD274 antigen	Mus musculus	35-40
34307147-6	2021	Based on Western blotting results, PD-L1 expression was reduced in Nrf2 knockout (KO) female and E2-treated male mice when compared with their wild-type counterparts, following AOM/DSS treatment; this supports the association of PD-L1 expression with tumor progression.	dss	181-184	nuclear factor, erythroid derived 2, like 2	Mus musculus	67-71
34307147-6	2021	Based on Western blotting results, PD-L1 expression was reduced in Nrf2 knockout (KO) female and E2-treated male mice when compared with their wild-type counterparts, following AOM/DSS treatment; this supports the association of PD-L1 expression with tumor progression.	dss	181-184	CD274 antigen	Mus musculus	229-234
34359965-12	2021	In summary, GP88 positivity in TCs is a negative prognostic factor for DSS and RFS.	dss	71-74	granulin precursor	Homo sapiens	12-16
34359965-13	2021	In addition, GP88 positivity can mark ICs that are associated with a good prognosis (OS, DSS and RFS).	dss	89-92	granulin precursor	Homo sapiens	13-17
34300195-9	2021	Moreover, upregulated MUC2 immunoexpression was an independent prognostic factor for worse DSS (p < 0.001), LRFS (p = 0.008), and MeFS (p = 0.003) at the multivariate level.	dss	91-94	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	22-26
34239017-7	2021	Notably, low miR-29a expression was the only factor, other than residual tumor status, to be an independent prognostic biomarker of worse OS and DSS.	dss	145-148	microRNA 29a	Homo sapiens	13-20
34239017-9	2021	Additionally, low expression of miR-29a was an independent prognostic biomarker of OS and DSS in gastric cancer patients.	dss	90-93	microRNA 29a	Homo sapiens	32-39
34229722-12	2021	Conversely, NLRP3 depletion protected against cognitive dysfunction, neuroinflammation, and neurological damage induced by DSS.	dss	123-126	NLR family, pyrin domain containing 3	Mus musculus	12-17
34357018-10	2021	At the multivariate level, CTSE overexpression remained an independent prognostic factor for poor DSS, MeFS (both p = 0.005), and LRFS (p = 0.019).	dss	98-101	cathepsin E	Homo sapiens	27-31
34168409-5	2021	METHODS: The IBD mouse model was conducted by adding dextran sodium sulfate (DSS), and the effect of EZH2 on DSS-induced colitis was assessed in the model.	dss	109-112	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	101-105
34162146-7	2021	CONCLUSION: Melatonin-mediated MT2 activated PI3K/AKT/Nrf2/RORalpha/SIRT1 pathway and suppressed NF-kappaB pathway, ultimately improved DSS-induced colitis, which provides evidence for melatonin as an efficient therapy against oxidative stress associated IBD.	dss	136-139	metallothionein 2	Mus musculus	31-34
34210024-8	2021	Moreover, we observed enhanced expression of IL-17A, IFNgamma and TNFalpha in colon tissues from the colitis mice (DSS-treated) given the EBV DNA compared to the other groups.	dss	115-118	interleukin 17A	Mus musculus	45-51
34210024-8	2021	Moreover, we observed enhanced expression of IL-17A, IFNgamma and TNFalpha in colon tissues from the colitis mice (DSS-treated) given the EBV DNA compared to the other groups.	dss	115-118	interferon gamma	Mus musculus	53-61
34210024-8	2021	Moreover, we observed enhanced expression of IL-17A, IFNgamma and TNFalpha in colon tissues from the colitis mice (DSS-treated) given the EBV DNA compared to the other groups.	dss	115-118	tumor necrosis factor	Mus musculus	66-74
34202399-6	2021	Furthermore, in multivariate analyses, high SPINK4 immunoexpression remained independently prognostic of inferior DSS and MeFS (p = 0.004 and p = 0.002).	dss	114-117	serine peptidase inhibitor Kazal type 4	Homo sapiens	44-50
34168409-8	2021	RESULTS: The colon length was inhibited in the DSS-treated mice and was enhanced by the EZH2 depletion in the system.	dss	47-50	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	88-92
34168409-9	2021	DSS treatment caused a decreased histological score in the mice, which was reversed by EZH2 depletion.	dss	0-3	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	87-91
34168409-10	2021	The inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, were induced in the DSS-treated mice, in which the depletion of EZH2 could reverse this effect.	dss	123-126	tumor necrosis factor	Mus musculus	36-63
34168409-10	2021	The inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, were induced in the DSS-treated mice, in which the depletion of EZH2 could reverse this effect.	dss	123-126	interleukin 6	Mus musculus	65-78
34168409-10	2021	The inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, were induced in the DSS-treated mice, in which the depletion of EZH2 could reverse this effect.	dss	123-126	interleukin 1 beta	Mus musculus	84-101
34168409-10	2021	The inflammatory cytokines, such as tumor necrosis factor-alpha, interleukin-6, and interleukin-1beta, were induced in the DSS-treated mice, in which the depletion of EZH2 could reverse this effect.	dss	123-126	enhancer of zeste 2 polycomb repressive complex 2 subunit	Mus musculus	167-171
34135557-13	2021	In the DSS group, there was an increase in colonic T helper CD4+ and T cytotoxic CD8+ cells by flow cytometry.	dss	7-10	CD4 antigen	Mus musculus	60-63
34199993-8	2021	In HPV-negative cases, S-TATI positivity was linked to poor OS (p = 0.01) and DSS (p = 0.05).	dss	78-81	serine peptidase inhibitor Kazal type 1	Homo sapiens	25-29
34087884-11	2021	The Cox regression analysis revealed that the expression of EFNA1 was also a risk factor for the disease-specific survival (DSS) and progression-free interval (PFI) of LGG patients.	dss	124-127	ephrin A1	Homo sapiens	60-65
34078403-11	2021	Moreover, expression of pro-fibrotic Tgfb1 and Pdgfb were lower in the colon of DSS treated Il20rb KO compared to that of WT mice.	dss	80-83	transforming growth factor, beta 1	Mus musculus	37-42
34078403-7	2021	RESULTS:  Increased amount of IL-24 was demonstrated in the serum and colon samples of children with IBD and DSS treated mice compared to that of controls.	dss	109-112	interleukin 24	Homo sapiens	30-35
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	CD4 antigen	Mus musculus	97-100
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	CD4 antigen	Mus musculus	106-109
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	interleukin 6	Mus musculus	173-177
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	mast cell protease 1	Mus musculus	182-187
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	interleukin 10	Mus musculus	214-219
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	mitogen-activated protein kinase 3	Mus musculus	295-301
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	mitogen-activated protein kinase 8	Mus musculus	303-306
34134952-7	2021	The mice in DSS group had severe pathologies in the colon with significantly increased ratios of CD4+ and CD4+/CD8+ T cells in peripheral blood and LPL, increased levels of IL-6 and MCP-1 but no obvious changes in IL-10 in colon homogenate, and significantly augmented phosphorylation levels of ERK1/2, JNK and P38.	dss	12-15	mitogen-activated protein kinase 14	Mus musculus	311-314
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	CD4 antigen	Mus musculus	117-120
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	interleukin 6	Mus musculus	197-201
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	mast cell protease 1	Mus musculus	206-211
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	interleukin 10	Mus musculus	233-238
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	mitogen-activated protein kinase 3	Mus musculus	298-304
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	mitogen-activated protein kinase 8	Mus musculus	306-309
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	23-26	mitogen-activated protein kinase 14	Mus musculus	314-317
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	CD4 antigen	Mus musculus	117-120
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	interleukin 6	Mus musculus	197-201
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	mast cell protease 1	Mus musculus	206-211
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	interleukin 10	Mus musculus	233-238
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	mitogen-activated protein kinase 3	Mus musculus	298-304
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	mitogen-activated protein kinase 8	Mus musculus	306-309
34134952-8	2021	Compared with those in DSS group, the mice in DSS+ rCsHscB group showed ameliorated colon pathologies with decreased CD4+T/CD8+T cell ratio in the peripheral blood and LPL, significantly decreased IL-6 and MCP-1 levels and increased IL-10 in colon homogenate, and lowered phosphorylation levels of ERK1/2, JNK and P38.	dss	46-49	mitogen-activated protein kinase 14	Mus musculus	314-317
34090510-14	2021	Consequently, IL-1beta-primed ERCs exhibited an enhanced therapeutic effect in the attenuation of DSS-induced colitis.	dss	98-101	interleukin 1 alpha	Mus musculus	14-22
34123827-11	2021	Multivariate analysis demonstrated that METTL18 was an independent factor for OS (HR: 2.093, P < 0.001), DSS (HR: 2.404, P = 0.015), and PFI (HR: 1.133, P = 0.006).	dss	105-108	methyltransferase like 18	Homo sapiens	40-47
34067858-0	2021	Pathological Role of Pin1 in the Development of DSS-Induced Colitis.	dss	48-51	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	21-25
34078403-11	2021	Moreover, expression of pro-fibrotic Tgfb1 and Pdgfb were lower in the colon of DSS treated Il20rb KO compared to that of WT mice.	dss	80-83	platelet derived growth factor, B polypeptide	Mus musculus	47-52
34078403-11	2021	Moreover, expression of pro-fibrotic Tgfb1 and Pdgfb were lower in the colon of DSS treated Il20rb KO compared to that of WT mice.	dss	80-83	interleukin 20	Mus musculus	92-96
34078403-12	2021	The disease activity index of colitis was less severe in DSS treated Il20rb KO compared to WT mice.	dss	57-60	interleukin 20	Mus musculus	69-73
34069237-6	2021	Protein expression of CALML5 and LIMA1 were significantly associated with five-year DSS in the OTSCC cohort in univariate analyses (p = 0.016 and p = 0.043, respectively).	dss	84-87	calmodulin like 5	Homo sapiens	22-28
34067858-2	2021	In this study, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein was shown to be dramatically upregulated in the colons of dextran sodium sulfate (DSS)-induced ulcerative colitis model mice.	dss	167-170	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	15-69
34067858-2	2021	In this study, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1) protein was shown to be dramatically upregulated in the colons of dextran sodium sulfate (DSS)-induced ulcerative colitis model mice.	dss	167-170	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	71-75
34067858-3	2021	Interestingly, Pin1 knockout (KO) mice exhibited significant attenuation of DSS-induced colitis compared to wild-type (WT) mice, based on various parameters, including body weight, colon length, microscopic observation of the intestinal mucosa, inflammatory cytokine expression, and cleaved caspase-3.	dss	76-79	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	15-19
34067858-6	2021	Finally, oral administration of Pin1 inhibitor partially but significantly prevented DSS-induced colitis in mice, raising the possibility of Pin1 inhibitors serving as therapeutic agents for IBD.	dss	85-88	peptidyl-prolyl cis/trans isomerase, NIMA-interacting 1	Mus musculus	32-36
34069237-6	2021	Protein expression of CALML5 and LIMA1 were significantly associated with five-year DSS in the OTSCC cohort in univariate analyses (p = 0.016 and p = 0.043, respectively).	dss	84-87	LIM domain and actin binding 1	Homo sapiens	33-38
34249260-1	2021	ameliorates DSS-induced ulcerative colitis by affecting TLR4/NF-kappaB and TLR4/MAPK signaling pathway in a mouse model.	dss	12-15	toll-like receptor 4	Mus musculus	56-60
34231485-11	2021	ICA significantly inhibited expressions of IL-6 and TNF-alpha compared to the DSS group (P < .05).	dss	78-81	interleukin 6	Mus musculus	43-47
34231485-11	2021	ICA significantly inhibited expressions of IL-6 and TNF-alpha compared to the DSS group (P < .05).	dss	78-81	tumor necrosis factor	Mus musculus	52-61
34231485-12	2021	p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05).	dss	24-27	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	2-5
34231485-12	2021	p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05).	dss	24-27	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	7-10
34066040-8	2021	Higher expression of AKT was significantly more prevalent in high-grade tumors and predictive of DSS and OS in the Kaplan-Meier analysis, and an independent predictor of worse OS and DSS in the multivariate regression analysis.	dss	97-100	AKT serine/threonine kinase 1	Homo sapiens	21-24
34066040-8	2021	Higher expression of AKT was significantly more prevalent in high-grade tumors and predictive of DSS and OS in the Kaplan-Meier analysis, and an independent predictor of worse OS and DSS in the multivariate regression analysis.	dss	183-186	AKT serine/threonine kinase 1	Homo sapiens	21-24
34249260-1	2021	ameliorates DSS-induced ulcerative colitis by affecting TLR4/NF-kappaB and TLR4/MAPK signaling pathway in a mouse model.	dss	12-15	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	61-70
34249260-1	2021	ameliorates DSS-induced ulcerative colitis by affecting TLR4/NF-kappaB and TLR4/MAPK signaling pathway in a mouse model.	dss	12-15	toll-like receptor 4	Mus musculus	75-79
34249260-8	2021	Moreover, FEC treatment remarkably down-regulated the levels of myeloperoxidase (MPO), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6) and up-regulated the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and interleukin 10 (IL-10) in the colon of DSS mice (P<0.05).	dss	320-323	myeloperoxidase	Mus musculus	64-79
34249260-8	2021	Moreover, FEC treatment remarkably down-regulated the levels of myeloperoxidase (MPO), interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha), and interleukin 6 (IL-6) and up-regulated the levels of superoxide dismutase (SOD), catalase (CAT), glutathione (GSH), and interleukin 10 (IL-10) in the colon of DSS mice (P<0.05).	dss	320-323	interleukin 10	Mus musculus	297-302
34231485-12	2021	p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05).	dss	80-83	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	2-5
34231485-12	2021	p-p65/ p65 ratio in the DSS + ICA group was remarkably enhanced compared to the DSS group (P < .05).	dss	80-83	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	7-10
34087454-8	2021	Additionally, comparing to WT mice, IDO-/- mice treated with AOM/DSS exhibited fewer and smaller tumor burdens in colon, with less Treg and more CD8+ T cells infiltration, while Kyn administration abolished this regulation.	dss	65-68	indoleamine 2,3-dioxygenase 1	Mus musculus	36-39
34087454-9	2021	Rag1-/- mice were more sensitive to AOM/DSS-induced colitis-associated colon cancer (CRC) comparing with the wild-type (WT) mice, suggesting that T cells-mediated adaptive immunity indeed played a critical role in CRC.	dss	40-43	recombination activating 1	Mus musculus	0-4
35487304-9	2022	DSS treatment caused a significant increase of DAT and D1R myenteric immunoreactivity as well as of D1R and D2R mRNA levels, accompanied by a significant reduction of dopamine-mediated relaxation, involving primarily D1-like receptors.	dss	0-3	solute carrier family 6 (neurotransmitter transporter, dopamine), member 3	Mus musculus	47-50
35179790-3	2022	MLH1-/- mice deficient in MMR are prone to developing tumors in the colon, upon oral administration of dextran sodium sulfate (DSS), at a rate of more than 70%.	dss	127-130	mutL homolog 1	Mus musculus	0-4
35179790-5	2022	This was accomplished via high throughput exome sequencing of DSS-induced colorectal tumors in the MLH1-/- mice and predicting the most highly immunogenic mutant gene products processed and presented as antigens in C57B6 MHC-I molecules.	dss	62-65	mutL homolog 1	Mus musculus	99-103
35588304-3	2022	The results indicated that CCHP administration alleviated the histological changes of DSS-induced colitis in mice and downregulated the mRNA level of TNF-alpha, IL-1beta, IL-6 and Cox-2.	dss	86-89	tumor necrosis factor	Mus musculus	150-159
35561427-7	2022	Moreover, lower doses of SDH showed the similar or better efficacy than cyclosporine A (CsA) and mesalazine in DSS- or TNBS-induced colitis animals.	dss	111-114	serine dehydratase	Homo sapiens	25-28
35274760-5	2022	Results showed that the upregulation of MCTS1 in LSCC is linked to poor progression-free survival (PFS) and disease-specific survival (DSS).	dss	135-138	MCTS1 re-initiation and release factor	Homo sapiens	40-45
35572494-13	2022	Immunohistochemical analysis of 124 NPC tissues from patients who underwent cisplatin-based chemoradiotherapy indicated that high UBE2B expression levels were associated with poor DSS, DMeFS and LRFS.	dss	180-183	ubiquitin conjugating enzyme E2 B	Homo sapiens	130-135
35572494-14	2022	Multivariate regression analysis of factors influencing survival also confirmed that high UBE2B expression levels were a statistically significant independent risk factor for poor clinical outcomes in terms of DSS (hazard ratio (HR), 1.955; 95% CI 1.164-3.282), DMeFS (HR, 2.141; 95% CI 1.206-3.801) and LRFS (HR, 2.557; 95 CI 1.313-4.981).	dss	210-213	ubiquitin conjugating enzyme E2 B	Homo sapiens	90-95
35622222-2	2022	METHODS: We have examined The Cancer Genome Atlas dataset to check the relations between GPR35 expression pattern and OS or DSS of patients with colorectal cancer (CRC).	dss	124-127	G protein-coupled receptor 35	Homo sapiens	89-94
35569814-5	2022	METHODS: We first compared the epithelial healing effects of RSPO2 and a Wnt mimetic with broad Fzd-specificity in an acute Dextran Sodium Sulfate (DSS) mouse colitis model.	dss	148-151	R-spondin 2	Mus musculus	61-66
35574272-8	2022	In addition, DSS treatment induced downregulation of tight junction (TJ) protein, anti-inflammatory cytokines (IL-10 and TGF-beta), and the number of anti-inflammatory B cells (CD1d+) in intestinal epithelial tissues, while upregulated proinflammatory cytokines (IL-6 and TNF-alpha), proinflammatory B cells (CD138+), and DNA methylation level.	dss	13-16	interleukin 10	Mus musculus	111-116
35574272-8	2022	In addition, DSS treatment induced downregulation of tight junction (TJ) protein, anti-inflammatory cytokines (IL-10 and TGF-beta), and the number of anti-inflammatory B cells (CD1d+) in intestinal epithelial tissues, while upregulated proinflammatory cytokines (IL-6 and TNF-alpha), proinflammatory B cells (CD138+), and DNA methylation level.	dss	13-16	transforming growth factor alpha	Mus musculus	121-129
35574272-8	2022	In addition, DSS treatment induced downregulation of tight junction (TJ) protein, anti-inflammatory cytokines (IL-10 and TGF-beta), and the number of anti-inflammatory B cells (CD1d+) in intestinal epithelial tissues, while upregulated proinflammatory cytokines (IL-6 and TNF-alpha), proinflammatory B cells (CD138+), and DNA methylation level.	dss	13-16	CD1d1 antigen	Mus musculus	177-181
35574272-8	2022	In addition, DSS treatment induced downregulation of tight junction (TJ) protein, anti-inflammatory cytokines (IL-10 and TGF-beta), and the number of anti-inflammatory B cells (CD1d+) in intestinal epithelial tissues, while upregulated proinflammatory cytokines (IL-6 and TNF-alpha), proinflammatory B cells (CD138+), and DNA methylation level.	dss	13-16	interleukin 6	Mus musculus	263-267
35574272-8	2022	In addition, DSS treatment induced downregulation of tight junction (TJ) protein, anti-inflammatory cytokines (IL-10 and TGF-beta), and the number of anti-inflammatory B cells (CD1d+) in intestinal epithelial tissues, while upregulated proinflammatory cytokines (IL-6 and TNF-alpha), proinflammatory B cells (CD138+), and DNA methylation level.	dss	13-16	tumor necrosis factor	Mus musculus	272-281
35574272-8	2022	In addition, DSS treatment induced downregulation of tight junction (TJ) protein, anti-inflammatory cytokines (IL-10 and TGF-beta), and the number of anti-inflammatory B cells (CD1d+) in intestinal epithelial tissues, while upregulated proinflammatory cytokines (IL-6 and TNF-alpha), proinflammatory B cells (CD138+), and DNA methylation level.	dss	13-16	syndecan 1	Mus musculus	309-314
35565884-7	2022	Furthermore, L. plantarum-12 oral administration significantly ameliorated the colon injury of the AOM/DSS-treated mice by enhancing colonic tight junction protein level and promoting tumor cells death via down-regulating PCNA (proliferating cell nuclear antigen) and up-regulating pro-apoptotic Bax.	dss	103-106	proliferating cell nuclear antigen	Mus musculus	222-226
35565884-7	2022	Furthermore, L. plantarum-12 oral administration significantly ameliorated the colon injury of the AOM/DSS-treated mice by enhancing colonic tight junction protein level and promoting tumor cells death via down-regulating PCNA (proliferating cell nuclear antigen) and up-regulating pro-apoptotic Bax.	dss	103-106	proliferating cell nuclear antigen	Mus musculus	228-262
35501725-10	2022	Kaplan-Meier survival analysis revealed that patients with MICAL-L2 had shorter OS and DSS.	dss	87-90	MICAL like 2	Homo sapiens	59-67
35510770-11	2022	Among nonchemotherapy patients, SPARC stromal expression was associated with poorer OS and DSS (P=0.0074 and 0.033, respectively).	dss	91-94	secreted protein acidic and cysteine rich	Homo sapiens	32-37
35037417-9	2022	Furthermore, positive PD-L2 expression on TCs was an independent risk factor for lower DSS in the pN0 (p = 0.023), moderate and well tumour differentiation (p = 0.004), low BRCA1 (p = 0.017), wild-type p53 (p = 0.034), and proficient mismatch repair (p = 0.004) subgroups.	dss	87-90	programmed cell death 1 ligand 2	Homo sapiens	22-27
35037417-10	2022	Moreover, post-operative adjuvant chemotherapy could significantly affect DSS, regardless of PD-L1/PD-L2 expression status (positive or negative) on TCs, while it only prolonged DSS in PDL1-ICs(-) (p < 0.0001) and PDL2-ICs(-) (p < 0.0001) subgroups.	dss	178-181	CD274 molecule	Homo sapiens	185-189
35248848-7	2022	HT suppressed expression levels of NLRP3, caspase-1, and ASC mRNA and downregulated interleukin-18 and interleukin-1beta levels in the DSS group (P < 0.01).	dss	135-138	NLR family, pyrin domain containing 3	Mus musculus	35-40
35529035-7	2022	Results: Compared with that of the control group, body weight of mice in DSS group was significantly reduced, stool was not formed or presented with loose stools, there was occult blood or blood in the stool, hair color lost luster, disease activity index (DAI) score was significantly increased, and colonic mucosal epithelial cells showed colitis; LC3-II/LC3-I and Beclin1 expression were significantly decreased (P < 0.05), p62 was significantly increased, and autophagy was not obvious.	dss	73-76	beclin 1, autophagy related	Mus musculus	367-374
35529035-7	2022	Results: Compared with that of the control group, body weight of mice in DSS group was significantly reduced, stool was not formed or presented with loose stools, there was occult blood or blood in the stool, hair color lost luster, disease activity index (DAI) score was significantly increased, and colonic mucosal epithelial cells showed colitis; LC3-II/LC3-I and Beclin1 expression were significantly decreased (P < 0.05), p62 was significantly increased, and autophagy was not obvious.	dss	73-76	nucleoporin 62	Mus musculus	427-430
35529035-8	2022	In addition, compared with that of the DSS group, the diet of mice in the Cur group was improved, the decline of body weight was slowed down, the hair glossiness was restored, the blood in the stool gradually decreased or occulted, the DAI score was decreased, the colon tissue was significantly improved, the expressions of LC3-II/LC3-I and Beclin1 were significantly increased (P < 0.05), and the p62 was significantly decreased.	dss	39-42	beclin 1, autophagy related	Mus musculus	342-349
35529035-8	2022	In addition, compared with that of the DSS group, the diet of mice in the Cur group was improved, the decline of body weight was slowed down, the hair glossiness was restored, the blood in the stool gradually decreased or occulted, the DAI score was decreased, the colon tissue was significantly improved, the expressions of LC3-II/LC3-I and Beclin1 were significantly increased (P < 0.05), and the p62 was significantly decreased.	dss	39-42	nucleoporin 62	Mus musculus	399-402
35563010-2	2022	Methods: CA-CRC was induced in P2X7R+/+ and P2X7R-/- mice with azoxymethane (AOM) combined with dextran sodium sulfate (DSS).	dss	120-123	cation channel, sperm associated 3	Mus musculus	9-15
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	thioredoxin interacting protein	Mus musculus	48-53
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	NLR family, pyrin domain containing 3	Mus musculus	55-60
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	steroid sulfatase	Mus musculus	62-65
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	caspase 1	Mus musculus	67-76
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	gasdermin D	Mus musculus	78-83
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	interleukin 1 alpha	Mus musculus	94-102
35373915-7	2022	Compared with the DSS group, the expressions of TXNIP, NLRP3, ASC, Caspase-1, GSDMD, N-GSDMD, IL-1beta, and IL-18 in the colon were decreased after administration of 10-HDA.	dss	18-21	interleukin 18	Mus musculus	108-113
35373915-8	2022	10-HDA also elevated the barrier integrity and the expressions of ZO-1 and Occludin in colonic epithelium exposed to DSS.	dss	117-120	tight junction protein 1	Mus musculus	66-70
35373915-8	2022	10-HDA also elevated the barrier integrity and the expressions of ZO-1 and Occludin in colonic epithelium exposed to DSS.	dss	117-120	occludin	Mus musculus	75-83
35373915-10	2022	CONCLUSION: 10-HDA alleviates DSS-induced colitis by regulating the NLRP3 inflammasome-mediated pyroptotic pathway and enhancing colonic barrier function.	dss	30-33	NLR family, pyrin domain containing 3	Mus musculus	68-73
35378241-4	2022	MiR-182-5p and SMARCA5 were upregulated and DNMT3A, beta-catenin, and Cyclin D1 were downregulated in UC patients, IL-1beta-stimulated Caco-2 cells, and DSS-treated mice.	dss	153-156	DNA methyltransferase 3 alpha	Homo sapiens	44-50
35378241-4	2022	MiR-182-5p and SMARCA5 were upregulated and DNMT3A, beta-catenin, and Cyclin D1 were downregulated in UC patients, IL-1beta-stimulated Caco-2 cells, and DSS-treated mice.	dss	153-156	catenin beta 1	Homo sapiens	52-64
35378241-4	2022	MiR-182-5p and SMARCA5 were upregulated and DNMT3A, beta-catenin, and Cyclin D1 were downregulated in UC patients, IL-1beta-stimulated Caco-2 cells, and DSS-treated mice.	dss	153-156	cyclin D1	Homo sapiens	70-79
35378241-8	2022	SMARCA5 silencing or miR-182-5p inhibition ameliorated intestinal barrier dysfunction in DSS-treated mice.	dss	89-92	microRNA 182	Mus musculus	21-28
35346284-12	2022	Anemonin inhibited DSS-induced colon tissue inflammation as the release of IL-1beta, TNF-alpha, and IL-6 was significantly suppressed.	dss	19-22	interleukin 1 alpha	Mus musculus	75-83
35346284-12	2022	Anemonin inhibited DSS-induced colon tissue inflammation as the release of IL-1beta, TNF-alpha, and IL-6 was significantly suppressed.	dss	19-22	tumor necrosis factor	Mus musculus	85-94
35346284-12	2022	Anemonin inhibited DSS-induced colon tissue inflammation as the release of IL-1beta, TNF-alpha, and IL-6 was significantly suppressed.	dss	19-22	interleukin 6	Mus musculus	100-104
35399505-3	2022	Vim-/- mice challenged with dextran sodium sulfate (DSS) had worse colitis manifestations than wild-type (WT) mice.	dss	52-55	vimentin	Mus musculus	0-3
35399505-6	2022	Further, we demonstrated that Vim-/- mice did not develop colitis-associated cancer model upon DSS treatment spontaneously but increased tumor numbers and size in the distal colon in the azoxymethane/DSS model comparing with WT mice.	dss	95-98	vimentin	Mus musculus	30-33
35399505-6	2022	Further, we demonstrated that Vim-/- mice did not develop colitis-associated cancer model upon DSS treatment spontaneously but increased tumor numbers and size in the distal colon in the azoxymethane/DSS model comparing with WT mice.	dss	200-203	vimentin	Mus musculus	30-33
35326661-9	2022	High levels of TIL Foxp3 (+) and CD68 (+) macrophages predicted better 5-year DSS.	dss	78-81	forkhead box P3	Homo sapiens	19-24
35326661-9	2022	High levels of TIL Foxp3 (+) and CD68 (+) macrophages predicted better 5-year DSS.	dss	78-81	CD68 molecule	Homo sapiens	33-37
35246034-5	2022	Moreover, an in vivo colitis model utilizing dextran sodium sulfate (DSS) confirmed increased levels of proinflammatory cytokines and chemokines in the colon of DSS treated ERAP1-/- mice as compared to identically stimulated WT mice.	dss	69-72	endoplasmic reticulum aminopeptidase 1	Mus musculus	173-178
35246034-5	2022	Moreover, an in vivo colitis model utilizing dextran sodium sulfate (DSS) confirmed increased levels of proinflammatory cytokines and chemokines in the colon of DSS treated ERAP1-/- mice as compared to identically stimulated WT mice.	dss	161-164	endoplasmic reticulum aminopeptidase 1	Mus musculus	173-178
35235149-3	2022	Compared with wild-type mice, Usp47 knockout mice are more susceptible to dextran sodium sulfate (DSS)-induced acute and chronic colitis with higher inflammatory cytokines expression and severe intestinal tissue damage.	dss	98-101	ubiquitin specific peptidase 47	Mus musculus	30-35
35235149-5	2022	And, DSS-induced colitis of the Usp47 knockout mice depends on commensal bacteria.	dss	5-8	ubiquitin specific peptidase 47	Mus musculus	32-37
35197484-7	2022	The proposed DSS consists of a double-step feature selection and a decision tree, with the resulting output consisting of a combination of three highly discriminating proteins: TOP1, PDIA4, and OGN, that could be of interest for further clinical and experimental validation.	dss	13-16	DNA topoisomerase I	Homo sapiens	177-181
35197484-7	2022	The proposed DSS consists of a double-step feature selection and a decision tree, with the resulting output consisting of a combination of three highly discriminating proteins: TOP1, PDIA4, and OGN, that could be of interest for further clinical and experimental validation.	dss	13-16	protein disulfide isomerase family A member 4	Homo sapiens	183-188
35197484-7	2022	The proposed DSS consists of a double-step feature selection and a decision tree, with the resulting output consisting of a combination of three highly discriminating proteins: TOP1, PDIA4, and OGN, that could be of interest for further clinical and experimental validation.	dss	13-16	osteoglycin	Homo sapiens	194-197
35205671-5	2022	Here, we found that IRF9 had an oncogenic effect in CRC; loss of IRF9 reduced tumorigenesis in both azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced and spontaneous CRC models.	dss	143-146	interferon regulatory factor 9	Homo sapiens	20-24
35205671-5	2022	Here, we found that IRF9 had an oncogenic effect in CRC; loss of IRF9 reduced tumorigenesis in both azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced and spontaneous CRC models.	dss	143-146	interferon regulatory factor 9	Homo sapiens	65-69
35205671-6	2022	IRF9 also reduced DSS-induced colitis and inflammation in the colon, but it had no effect on the NF-kappaB and MAPK signaling activation.	dss	18-21	interferon regulatory factor 9	Homo sapiens	0-4
35222510-11	2021	ATF6 upregulation and EMC6 and APAF1 downregulations significantly correlated with the poor RFS, OS, and DSS of PC patients.	dss	105-108	ER membrane protein complex subunit 6	Homo sapiens	22-26
35222510-11	2021	ATF6 upregulation and EMC6 and APAF1 downregulations significantly correlated with the poor RFS, OS, and DSS of PC patients.	dss	105-108	apoptotic peptidase activating factor 1	Homo sapiens	31-36
35400083-8	2022	Recurrence-free survival (RFS) and DSS relevantly deteriorated from the group of pathologic stages 0, IA1, and IA2 to the group IA3 and IB.	dss	35-38	INSM transcriptional repressor 1	Homo sapiens	102-105
35400083-8	2022	Recurrence-free survival (RFS) and DSS relevantly deteriorated from the group of pathologic stages 0, IA1, and IA2 to the group IA3 and IB.	dss	35-38	protein tyrosine phosphatase receptor type N	Homo sapiens	111-114
35223996-9	2022	Importantly, in pancreatic adenocarcinoma (PAAD), overexpression of RBM15 is associated with patients" OS, DFI, PFI, or DSS.	dss	120-123	RNA binding motif protein 15	Homo sapiens	68-73
35187070-4	2021	Increased PAFAH1B3 expression correlated with poor overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) of NSCLC and LIHC, and has potential as an independent risk factor for overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) during LIHC.	dss	101-104	platelet activating factor acetylhydrolase 1b catalytic subunit 3	Homo sapiens	10-18
35187070-4	2021	Increased PAFAH1B3 expression correlated with poor overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) of NSCLC and LIHC, and has potential as an independent risk factor for overall survival (OS), disease-specific survival (DSS), and progression-free interval (PFI) during LIHC.	dss	264-267	platelet activating factor acetylhydrolase 1b catalytic subunit 3	Homo sapiens	10-18
35090523-7	2022	Furthermore, high level co-expression of SALL4/ALDH1A1 was a significant predictor of worse DSS and PFS in the univariate analysis.	dss	92-95	spalt like transcription factor 4	Homo sapiens	41-46
35090523-7	2022	Furthermore, high level co-expression of SALL4/ALDH1A1 was a significant predictor of worse DSS and PFS in the univariate analysis.	dss	92-95	aldehyde dehydrogenase 1 family member A1	Homo sapiens	47-54
35090523-9	2022	Moreover, the co-expression of SALL4/ALDH1A1 added prognostic values of DSS in patients with SOC who had grade III versus grade I in multivariate analysis.	dss	72-75	spalt like transcription factor 4	Homo sapiens	31-36
35090523-9	2022	Moreover, the co-expression of SALL4/ALDH1A1 added prognostic values of DSS in patients with SOC who had grade III versus grade I in multivariate analysis.	dss	72-75	aldehyde dehydrogenase 1 family member A1	Homo sapiens	37-44
35126466-5	2021	The Kaplan-Meier plotter demonstrated that high SCN4A mRNA expression was correlated with better overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS) and that high expression of SCN7A mRNA was associated with better OS; however, in Asians, higher SCN4A was correlated with better OS and DSS, and higher SCN7A was well correlated with better OS, recurrence-free survival (RFS), DSS and PFS.	dss	147-150	sodium voltage-gated channel alpha subunit 4	Homo sapiens	48-53
35126466-5	2021	The Kaplan-Meier plotter demonstrated that high SCN4A mRNA expression was correlated with better overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS) and that high expression of SCN7A mRNA was associated with better OS; however, in Asians, higher SCN4A was correlated with better OS and DSS, and higher SCN7A was well correlated with better OS, recurrence-free survival (RFS), DSS and PFS.	dss	325-328	sodium voltage-gated channel alpha subunit 4	Homo sapiens	48-53
35126466-5	2021	The Kaplan-Meier plotter demonstrated that high SCN4A mRNA expression was correlated with better overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS) and that high expression of SCN7A mRNA was associated with better OS; however, in Asians, higher SCN4A was correlated with better OS and DSS, and higher SCN7A was well correlated with better OS, recurrence-free survival (RFS), DSS and PFS.	dss	325-328	sodium voltage-gated channel alpha subunit 7	Homo sapiens	216-221
35126466-5	2021	The Kaplan-Meier plotter demonstrated that high SCN4A mRNA expression was correlated with better overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS) and that high expression of SCN7A mRNA was associated with better OS; however, in Asians, higher SCN4A was correlated with better OS and DSS, and higher SCN7A was well correlated with better OS, recurrence-free survival (RFS), DSS and PFS.	dss	415-418	sodium voltage-gated channel alpha subunit 4	Homo sapiens	48-53
35126466-5	2021	The Kaplan-Meier plotter demonstrated that high SCN4A mRNA expression was correlated with better overall survival (OS), disease-specific survival (DSS) and progression-free survival (PFS) and that high expression of SCN7A mRNA was associated with better OS; however, in Asians, higher SCN4A was correlated with better OS and DSS, and higher SCN7A was well correlated with better OS, recurrence-free survival (RFS), DSS and PFS.	dss	415-418	sodium voltage-gated channel alpha subunit 7	Homo sapiens	216-221
34983535-0	2022	TRIP6 promotes inflammatory damage via the activation of TRAF6 signaling in a murine model of DSS-induced colitis.	dss	94-97	thyroid hormone receptor interactor 6	Mus musculus	0-5
34983535-5	2022	FINDINGS: Wild-type (TRIP6+/+) mice developed more severe colitis following DSS-mediated disease induction relative to TRIP6-/- mice, as evidenced by more severe colonic inflammation and associated crypt damage.	dss	76-79	thyroid hormone receptor interactor 6	Mus musculus	21-26
34983535-6	2022	TRIP6 expression in wild-type mice was significantly elevated following DSS treatment.	dss	72-75	thyroid hormone receptor interactor 6	Mus musculus	0-5
34983535-9	2022	CONCLUSIONS: These in vivo data demonstrate that TRIP6 serves as a positive regulator of DSS-induced colitis through interactions with TRAF6 resulting in the activation of inflammatory TRAF6 signaling, highlighting its therapeutic promise as a protein that theoretically can be targeted to prevent or treat colitis.	dss	89-92	thyroid hormone receptor interactor 6	Mus musculus	49-54
34969735-6	2022	Cox"s multivariate analysis revealed that low serglycin expression was an independent factor for shorter DMFS (p=0.017) and DSS (p=0.020) in node-positive breast cancer patients.	dss	124-127	serglycin	Homo sapiens	46-55
35331877-0	2022	Preventive effect of Atractylodis Rhizoma extract on DSS-induced acute ulcerative colitis through the regulation of the MAPK/NF-kappaB signals in vivo and in vitro.	dss	53-56	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	125-134
35626155-10	2022	A high MCT4 intensity in SB-NETs was associated with better DSS when compared to low intensity (85.7 vs. 56.6%, p = 0.020).	dss	60-63	solute carrier family 16 member 3	Homo sapiens	7-11
35626155-11	2022	A high MCT4 percentage of positive cells resulted in better DSS when compared to a low percentage (77.4 vs. 49.1%, p = 0.059).	dss	60-63	solute carrier family 16 member 3	Homo sapiens	7-11
35626155-12	2022	MCT4 scores 0, 1, and 2 showed DSS of 52.8 vs. 58.8 vs. 100% (p = 0.025), respectively.	dss	31-34	solute carrier family 16 member 3	Homo sapiens	0-4
35549906-7	2022	For both OS and DSS, there was a significant correlation between the GNRI and several clinicopathological factors including age, body mass index, albumin, American Society of Anesthesiologists physical status score, depth of tumor invasion, lymph node metastasis, lymphatic invasion, pathological stage, operation duration, bleeding, procedure, approach, death due to primary disease, and death due to other disease.	dss	16-19	albumin	Homo sapiens	146-153
35511600-6	2022	Dextran sodium sulfate (DSS) upregulated the mRNA levels of IL-6, IL-1beta, IL-17, IL-12, tumor necrosis factor-alpha, C-C chemokine receptor type 5 and Bax in splenic lymphocytes (SPLs) and colon tissues, while G3c/D665 treatment conversely inhibited the increase in mRNA levels of these genes.	dss	24-27	interleukin 6	Mus musculus	60-64
35511600-6	2022	Dextran sodium sulfate (DSS) upregulated the mRNA levels of IL-6, IL-1beta, IL-17, IL-12, tumor necrosis factor-alpha, C-C chemokine receptor type 5 and Bax in splenic lymphocytes (SPLs) and colon tissues, while G3c/D665 treatment conversely inhibited the increase in mRNA levels of these genes.	dss	24-27	interleukin 1 alpha	Mus musculus	66-74
35511600-6	2022	Dextran sodium sulfate (DSS) upregulated the mRNA levels of IL-6, IL-1beta, IL-17, IL-12, tumor necrosis factor-alpha, C-C chemokine receptor type 5 and Bax in splenic lymphocytes (SPLs) and colon tissues, while G3c/D665 treatment conversely inhibited the increase in mRNA levels of these genes.	dss	24-27	interleukin 17A	Mus musculus	76-81
35511600-6	2022	Dextran sodium sulfate (DSS) upregulated the mRNA levels of IL-6, IL-1beta, IL-17, IL-12, tumor necrosis factor-alpha, C-C chemokine receptor type 5 and Bax in splenic lymphocytes (SPLs) and colon tissues, while G3c/D665 treatment conversely inhibited the increase in mRNA levels of these genes.	dss	24-27	tumor necrosis factor	Mus musculus	83-117
35511600-6	2022	Dextran sodium sulfate (DSS) upregulated the mRNA levels of IL-6, IL-1beta, IL-17, IL-12, tumor necrosis factor-alpha, C-C chemokine receptor type 5 and Bax in splenic lymphocytes (SPLs) and colon tissues, while G3c/D665 treatment conversely inhibited the increase in mRNA levels of these genes.	dss	24-27	chemokine (C-C motif) receptor 5	Mus musculus	119-148
35511600-6	2022	Dextran sodium sulfate (DSS) upregulated the mRNA levels of IL-6, IL-1beta, IL-17, IL-12, tumor necrosis factor-alpha, C-C chemokine receptor type 5 and Bax in splenic lymphocytes (SPLs) and colon tissues, while G3c/D665 treatment conversely inhibited the increase in mRNA levels of these genes.	dss	24-27	BCL2-associated X protein	Mus musculus	153-156
35178902-10	2022	RESULTS: We found that DRE-H attenuated DSS-triggered colonic mucosal damage.	dss	40-43	down-regulated in hepatocellular carcinoma	Mus musculus	23-28
35178902-11	2022	The DSS-induced inflammatory responses and oxidative stress in the bloodstream and colon tissues were dramatically inhibited by DRE-H administration.	dss	4-7	down-regulated in hepatocellular carcinoma	Mus musculus	128-133
35178902-12	2022	Also, this plant impaired DSS-provoked phosphorylation levels of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), p38 mitogen-activated protein kinases (p38), p65, and IkappaB.	dss	26-29	mitogen-activated protein kinase 8	Mus musculus	111-135
35178902-12	2022	Also, this plant impaired DSS-provoked phosphorylation levels of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), p38 mitogen-activated protein kinases (p38), p65, and IkappaB.	dss	26-29	mitogen-activated protein kinase 8	Mus musculus	137-140
35178902-12	2022	Also, this plant impaired DSS-provoked phosphorylation levels of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), p38 mitogen-activated protein kinases (p38), p65, and IkappaB.	dss	26-29	mitogen-activated protein kinase 14	Mus musculus	182-185
35178902-12	2022	Also, this plant impaired DSS-provoked phosphorylation levels of extracellular signal-regulated kinases (ERK), c-Jun N-terminal kinases (JNK), p38 mitogen-activated protein kinases (p38), p65, and IkappaB.	dss	26-29	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	188-191
35178902-14	2022	CONCLUSIONS: The DRE-H is capable of relieving DSS-induced UC, and its mechanism links to the MAPK pathways.	dss	47-50	down-regulated in hepatocellular carcinoma	Mus musculus	17-22
35248848-7	2022	HT suppressed expression levels of NLRP3, caspase-1, and ASC mRNA and downregulated interleukin-18 and interleukin-1beta levels in the DSS group (P < 0.01).	dss	135-138	caspase 1	Mus musculus	42-51
35248848-7	2022	HT suppressed expression levels of NLRP3, caspase-1, and ASC mRNA and downregulated interleukin-18 and interleukin-1beta levels in the DSS group (P < 0.01).	dss	135-138	steroid sulfatase	Mus musculus	57-60
35248848-7	2022	HT suppressed expression levels of NLRP3, caspase-1, and ASC mRNA and downregulated interleukin-18 and interleukin-1beta levels in the DSS group (P < 0.01).	dss	135-138	interleukin 18	Mus musculus	84-98
35248848-7	2022	HT suppressed expression levels of NLRP3, caspase-1, and ASC mRNA and downregulated interleukin-18 and interleukin-1beta levels in the DSS group (P < 0.01).	dss	135-138	interleukin 1 beta	Mus musculus	103-120
35378241-4	2022	MiR-182-5p and SMARCA5 were upregulated and DNMT3A, beta-catenin, and Cyclin D1 were downregulated in UC patients, IL-1beta-stimulated Caco-2 cells, and DSS-treated mice.	dss	153-156	microRNA 182	Homo sapiens	0-7
35557589-10	2022	Cox regression analysis revealed that CCDC68 was a risk factor for OS (P=0.047), PFI (P=0.048), and DSS (P=0.038).	dss	100-103	coiled-coil domain containing 68	Rattus norvegicus	38-44
35354432-8	2022	In multivariable analysis, high p62 expression was an independent prognostic factor for shorter DSS (p = 0.020) when follow up time was more than 5 years.	dss	96-99	sequestosome 1	Homo sapiens	32-35
35325567-9	2022	The ED-DSS magnitude of insulin dose change was consistently lower than that proposed by the physicians.	dss	7-10	insulin	Homo sapiens	24-31
35325567-11	2022	These results highlight the potential utilization of ED-DSS as a useful clinical tool to manage insulin titration and dose adjustments.	dss	56-59	insulin	Homo sapiens	96-103
35331316-5	2022	RESULTS: Chronic colitis models of CagA+ H. pylori-colonized mice treated with 2% Dextran sulphate sodium (DSS) were established to assess the disease activity and pertinent expression of tight junction proteins closely related to mucosal integrity.	dss	107-110	S100 calcium binding protein A8	Homo sapiens	35-39
35331316-6	2022	The aggravating effect of CagA+ H. pylori infection on DSS-induced chronic colitis was confirmed in mouse models.	dss	55-58	S100 calcium binding protein A8	Homo sapiens	26-30
35528785-11	2022	On multivariable analysis, cT2 versus cT3-4 tumor stage was significantly associated with better DSS (hazard ratio 1.02, 95% CI 1-1.05, p = 0.024).	dss	97-100	cancer/testis antigen 2	Homo sapiens	27-30
35528785-11	2022	On multivariable analysis, cT2 versus cT3-4 tumor stage was significantly associated with better DSS (hazard ratio 1.02, 95% CI 1-1.05, p = 0.024).	dss	97-100	cancer antigen 1	Homo sapiens	38-41
35232347-10	2022	Overexpression of RPS6KA4 predicted worse overall survival (OS, P=0.002), disease-specific survival (DSS, P=0.012), and progress free interval (PFI, P=0.031) for HCC.	dss	101-104	ribosomal protein S6 kinase A4	Homo sapiens	18-25
35326124-0	2022	Polyphenol Rich Forsythia suspensa Extract Alleviates DSS-Induced Ulcerative Colitis in Mice through the Nrf2-NLRP3 Pathway.	dss	54-57	nuclear factor, erythroid derived 2, like 2	Mus musculus	105-109
35326124-0	2022	Polyphenol Rich Forsythia suspensa Extract Alleviates DSS-Induced Ulcerative Colitis in Mice through the Nrf2-NLRP3 Pathway.	dss	54-57	NLR family, pyrin domain containing 3	Mus musculus	110-115
35326124-10	2022	In conclusion, we found that Forsythia suspensa extract significantly alleviated DSS-induced UC injury through the Nrf2-NLRP3 pathway and relieved metabolic dysfunction.	dss	81-84	nuclear factor, erythroid derived 2, like 2	Mus musculus	115-119
35326124-10	2022	In conclusion, we found that Forsythia suspensa extract significantly alleviated DSS-induced UC injury through the Nrf2-NLRP3 pathway and relieved metabolic dysfunction.	dss	81-84	NLR family, pyrin domain containing 3	Mus musculus	120-125
35237238-3	2021	This study was conducted to elucidate the protective impact of Tibetan tea extract (TTE) on dextran sodium sulfate (DSS)-induced colitis in mice.	dss	116-119	solute carrier family 7 (cationic amino acid transporter, y+ system), member 2	Mus musculus	71-74
35208981-7	2022	In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-kappaB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated.	dss	16-19	CD4 antigen	Mus musculus	51-54
35208981-7	2022	In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-kappaB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated.	dss	16-19	integrin subunit alpha M	Homo sapiens	60-65
35208981-7	2022	In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-kappaB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated.	dss	16-19	nuclear factor kappa B subunit 1	Homo sapiens	117-126
35208981-7	2022	In addition, in DSS-induced mice, the densities of CD4- and CD11b-positive cells, apoptotic rates, and activation of NF-kappaB and p-ERK1/2 MAPK intracellular signaling pathways were higher in those treated with BPE and BPFPE than in those not treated.	dss	16-19	mitogen-activated protein kinase 3	Homo sapiens	133-139
35134872-6	2022	Colitis was induced in WT mice and GPRC6A-/- mice through dextran sodium sulfate (DSS) administration or C. rodentium infection.	dss	82-85	G protein-coupled receptor, family C, group 6, member A	Mus musculus	35-41
35090523-10	2022	CONCLUSIONS: Our data demonstrated that high co-expression of SALL4/ALDH1A1 was found to be significantly associated with tumor aggressiveness and worse DSS or PFS in SOC patients.	dss	153-156	spalt like transcription factor 4	Homo sapiens	62-67
35090523-10	2022	CONCLUSIONS: Our data demonstrated that high co-expression of SALL4/ALDH1A1 was found to be significantly associated with tumor aggressiveness and worse DSS or PFS in SOC patients.	dss	153-156	aldehyde dehydrogenase 1 family member A1	Homo sapiens	68-75
35039003-4	2022	METHODS: Colitis model was established based on inducible intestinal conditional Cldn7 gene knockout mice (Cldn7fl/fl; villin-CreERT2), by feeding with dextran sodium sulfate (DSS).	dss	176-179	claudin 7	Mus musculus	81-86
35039003-8	2022	DSS-treated Cldn7 knockout mice promoted the migration of bacteria to the intestinal epithelium to some extent by damaging the intestinal mucus layer.	dss	0-3	claudin 7	Mus musculus	12-17
35039003-9	2022	Sequencing of 16S rRNA showed that DSS-treated Cldn7 knockout mice reduced the gut microbiota diversity and had greater relative abundance of Escherichia coli.	dss	35-38	claudin 7	Mus musculus	47-52
35039003-11	2022	Furthermore, the Tax4Fun analysis predicted that DSS-treated Cldn7 knockout mice enriched for microbiota impacting infectious diseases, immune system and metabolic functions.	dss	49-52	claudin 7	Mus musculus	61-66
34913458-0	2022	Lactiplantibacillus plantarum DMDL 9010 alleviates dextran sodium sulfate (DSS)-induced colitis and behavioral disorders by facilitating microbiota-gut-brain axis balance.	dss	75-78	utrophin	Mus musculus	30-34
34983695-3	2022	METHODS: Colitis was induced in mice lacking mPGES-1 (mPGES-1-/- mice) and wild-type (WT) mice by administering DSS for 7 days.	dss	112-115	prostaglandin E synthase	Mus musculus	45-52
34983695-3	2022	METHODS: Colitis was induced in mice lacking mPGES-1 (mPGES-1-/- mice) and wild-type (WT) mice by administering DSS for 7 days.	dss	112-115	prostaglandin E synthase	Mus musculus	54-61
34983695-7	2022	RESULTS: After administration of DSS, mPGES-1-/- mice exhibited more severe weight loss, diarrhea, and fecal bleeding than WT mice.	dss	33-36	prostaglandin E synthase	Mus musculus	38-45
34983695-9	2022	In WT mice, the colonic expression of mPGES-1 was highly induced on both mRNA and protein levels and colonic PGE2 increased significantly after DSS administration.	dss	144-147	prostaglandin E synthase	Mus musculus	38-45
34983695-13	2022	CD4+ T cell depletion effectively reduced symptoms of colitis as well as colonic expression of Th17 and Th1 cytokines in mPGES-1-/- mice, suggesting the requirement of CD4+ T cells in the exacerbation of DSS-induced colitis under mPGES-1 deficiency.	dss	204-207	prostaglandin E synthase	Mus musculus	121-128
35114502-10	2022	The same tendencies in OS or DSS were observed for the different age groups and different TNM groups, even the stage I, N0 (without metastases to lymph nodes), and ER (+) (estrogen receptor (ER)-positive) groups.	dss	29-32	estrogen receptor 1	Homo sapiens	164-166
35114502-10	2022	The same tendencies in OS or DSS were observed for the different age groups and different TNM groups, even the stage I, N0 (without metastases to lymph nodes), and ER (+) (estrogen receptor (ER)-positive) groups.	dss	29-32	estrogen receptor 1	Homo sapiens	172-189
35114502-10	2022	The same tendencies in OS or DSS were observed for the different age groups and different TNM groups, even the stage I, N0 (without metastases to lymph nodes), and ER (+) (estrogen receptor (ER)-positive) groups.	dss	29-32	estrogen receptor 1	Homo sapiens	191-193
35588304-3	2022	The results indicated that CCHP administration alleviated the histological changes of DSS-induced colitis in mice and downregulated the mRNA level of TNF-alpha, IL-1beta, IL-6 and Cox-2.	dss	86-89	interleukin 6	Mus musculus	171-175
35588304-3	2022	The results indicated that CCHP administration alleviated the histological changes of DSS-induced colitis in mice and downregulated the mRNA level of TNF-alpha, IL-1beta, IL-6 and Cox-2.	dss	86-89	cytochrome c oxidase II, mitochondrial	Mus musculus	180-185
2464533-7	1988	Both IFN-alpha producibility and NK activity of PBL obtained from the patients were depressed in parallel with the severity of DSS of the patients.	dss	127-130	interferon alpha 1	Homo sapiens	5-14