PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20405922-4	2010	This article will detail the structure-activity relationships (SAR) leading to a novel second generation series of highly potent spirocyclic hydantoin antagonists of LFA-1.	Hydantoins	141-150	integrin subunit alpha L	Homo sapiens	166-171
20573163-10	2010	Also discussed here are the formaldehyde-releasers MDM hydantoin, methenamine, N-methylolchloracetamide, paraformaldehyde, and Preventol D2.	Hydantoins	55-64	secreted LY6/PLAUR domain containing 1	Homo sapiens	51-54
20014751-11	2010	These results, when coupled with the known diastereomeric preference for excision of hydantoin lesions by the hNEIL1 enzyme, show the importance of defining both levels of lesion formation and diastereomeric preference of formation with regard to their potential impact on chromate carcinogenesis.	Hydantoins	85-94	nei like DNA glycosylase 1	Homo sapiens	110-116
20172725-1	2010	We disclose inhibitors of TNF-alpha converting enzyme (TACE) designed around a hydantoin zinc binding moiety.	Hydantoins	79-88	ADAM metallopeptidase domain 17	Homo sapiens	26-53
20172725-1	2010	We disclose inhibitors of TNF-alpha converting enzyme (TACE) designed around a hydantoin zinc binding moiety.	Hydantoins	79-88	ADAM metallopeptidase domain 17	Homo sapiens	55-59
20172725-2	2010	Crystal structures of inhibitors bound to TACE revealed monodentate coordination of the hydantoin to the zinc.	Hydantoins	88-97	ADAM metallopeptidase domain 17	Homo sapiens	42-46
20172725-4	2010	To our knowledge, these are the first reported X-ray structures of TACE with a hydantoin zinc ligand.	Hydantoins	79-88	ADAM metallopeptidase domain 17	Homo sapiens	67-71
20099873-0	2010	Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts.	Hydantoins	41-50	nei like DNA glycosylase 1	Homo sapiens	24-29
20182585-10	2010	Both hydantoins lowered beta-catenin, as reported previously.	Hydantoins	5-15	catenin beta 1	Homo sapiens	24-36
17188861-5	2007	The preceding paper described a novel series of potent and TACE-selective hydantoins and we previously described pyrimidinetrione (barbiturate) inhibitors of TACE, both of which contain the same P1" group as IK682.	Hydantoins	74-84	ADAM metallopeptidase domain 17	Homo sapiens	59-63
19556138-0	2009	Anti-tumor and anti-angiogenic activity of novel hydantoin derivatives: Inhibition of VEGF secretion in liver metastatic osteosarcoma cells.	Hydantoins	49-58	vascular endothelial growth factor A	Mus musculus	86-90
18543945-3	2008	In order to provide insight into the role of repair, the excision efficiency by hNEIL1 of these hydantoin lesions relative to other known substrates was determined.	Hydantoins	96-105	nei like DNA glycosylase 1	Homo sapiens	80-86
18543945-4	2008	Most notably, quantitative examination of the substrate specificity with hNEIL1 revealed that the hydantoin lesions are excised much more efficiently (>100-fold faster) than the reported standard substrates thymine glycol (Tg) and 5-hydroxycytosine (5-OHC).	Hydantoins	98-107	nei like DNA glycosylase 1	Homo sapiens	73-79
19597814-3	2009	The reaction proceeds via a three-step pathway: (a) the ring-opening cleavage of the hydantoin ring by a D-: hydantoinase (encoded by hyuH), (b) conversion of the resultant D-: N-carbamylamino acid to the corresponding amino acid by a D-: N-carbamoylase (encoded by hyuC), and (c) chemical or enzymatic racemization of the un-reacted hydantoin substrate.	Hydantoins	85-94	AWN88_RS03840	Agrobacterium tumefaciens	109-121
18607541-4	2009	From the SAR studies, it reveals that, the substitution at N-terminal in hydantoin ring plays key role in the antiproliferative activity.	Hydantoins	73-82	sarcosine dehydrogenase	Homo sapiens	9-12
18543945-0	2008	Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1.	Hydantoins	20-29	nei like DNA glycosylase 1	Homo sapiens	100-106
18543945-2	2008	Of these, the hydantoin lesions, guanidinohydantoin (Gh) and the two diastereomers of spiroiminodihydantoin (Sp1 and Sp2), have garnered much recent attention due to their unusual structures, high mutagenic potential, and detection in cells.	Hydantoins	14-23	Sp2 transcription factor	Homo sapiens	117-120
18270691-4	2008	The fifth SARM is a muscle-tissue specific agonist with a bicyclic hydantoin structure (BMS-564929).	Hydantoins	67-76	sterile alpha and TIR motif containing 1	Homo sapiens	10-14
17368021-0	2007	Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).	Hydantoins	0-10	ADAM metallopeptidase domain 17	Homo sapiens	85-130
17368021-0	2007	Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).	Hydantoins	0-10	ADAM metallopeptidase domain 17	Homo sapiens	132-136
17368021-1	2007	We have discovered selective and potent inhibitors of TACE that replace the common hydroxamate zinc binding group with a hydantoin, triazolone, and imidazolone heterocycle.	Hydantoins	121-130	ADAM metallopeptidase domain 17	Homo sapiens	54-58
17368021-2	2007	These novel heterocyclic inhibitors of a zinc metalloprotease were designed using a pharmacophore model that we previously described while developing hydantoin and pyrimidinetrione (barbiturate) inhibitors of TACE.	Hydantoins	150-159	ADAM metallopeptidase domain 17	Homo sapiens	209-213
17368021-3	2007	The potency and binding orientation of these inhibitors is discussed and they are modeled into the X-ray crystal structure of TACE and compared to hydroxamate and earlier hydantoin TACE inhibitors which share the same 4-[(2-methyl-4-quinolinyl)methoxy]benzoyl P1" group.	Hydantoins	171-180	ADAM metallopeptidase domain 17	Homo sapiens	181-185
17188863-1	2007	A series of novel hydantoins was designed and synthesized as structural alternatives to hydroxamate inhibitors of TACE.	Hydantoins	18-28	ADAM metallopeptidase domain 17	Homo sapiens	114-118
17188863-0	2007	Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).	Hydantoins	19-29	ADAM metallopeptidase domain 17	Homo sapiens	73-118
17188863-0	2007	Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-alpha converting enzyme (TACE).	Hydantoins	19-29	ADAM metallopeptidase domain 17	Homo sapiens	120-124
16959487-0	2006	Synthesis and SAR of novel hydantoin derivatives as selective androgen receptor modulators.	Hydantoins	27-36	sarcosine dehydrogenase	Homo sapiens	14-17
17125246-2	2006	This letter describes the discovery and preliminary SAR of spirocyclic hydantoin based LFA-1 antagonists that culminated in the identification of analog 8 as a clinical candidate.	Hydantoins	71-80	integrin subunit alpha L	Homo sapiens	87-92
15686933-0	2005	De novo design, synthesis, and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.	Hydantoins	94-103	integrin subunit alpha L	Homo sapiens	52-57
17003340-1	2006	Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids.	Hydantoins	107-117	aldo-keto reductase family 1 member B	Homo sapiens	33-49
16190759-0	2005	A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.	Hydantoins	43-52	aldo-keto reductase family 1 member B1	Rattus norvegicus	67-83
16190759-1	2005	Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a long-standing challenge.	Hydantoins	75-84	aldo-keto reductase family 1 member B1	Rattus norvegicus	98-114
16190759-1	2005	Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a long-standing challenge.	Hydantoins	75-84	aldo-keto reductase family 1 member B1	Rattus norvegicus	116-118
15686933-4	2005	This paper describes the de novo design, synthesis and in vitro activity of LFA-1 antagonists based on a bicyclic[5.5]hydantoin scaffold.	Hydantoins	118-127	integrin subunit alpha L	Homo sapiens	76-81
15288804-0	2004	Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.	Hydantoins	62-71	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	31-38
15288804-0	2004	Active-site characteristics of CYP2C19 and CYP2C9 probed with hydantoin and barbiturate inhibitors.	Hydantoins	62-71	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	43-49
12504329-2	2003	Binding of hydantoins to the I domain of LFA-1 is observed by size exclusion chromatography/mass spectrometry (SEC/MS) and by direct electrospray ionization mass spectrometry (ESI/MS).	Hydantoins	11-21	integrin subunit alpha L	Homo sapiens	41-46
12773033-0	2003	A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one.	Hydantoins	24-33	aldo-keto reductase family 1 member B1	Rattus norvegicus	68-84
12773033-1	2003	We report here on the discovery path that led to a structurally unprecedented non-hydantoin, non-carboxylic acid aldose reductase inhibitor, 24, which shows remarkably potent oral activity in normalizing elevated sorbitol levels and, more significantly, fructose levels in the sciatic nerve of chronically diabetic rats, with ED(90) values of 0.8 and 3 mpk, respectively.	Hydantoins	82-91	aldo-keto reductase family 1 member B1	Rattus norvegicus	113-129
15181632-3	2004	More basic conditions were required to form the bis-protected t-Boc hydantoin with the same reagent.	Hydantoins	68-77	BOC cell adhesion associated, oncogene regulated	Homo sapiens	64-67
15039302-3	2004	The aim of this study was to determine the structure-activity relationships for hPXR-mediated transactivation by barbiturates, hydantoins, and macrolide antibiotics.	Hydantoins	127-137	nuclear receptor subfamily 1 group I member 2	Homo sapiens	80-84
15039302-8	2004	In the case of hydantoins, only mephenytoin and ethotoin, which have an alkylchain at the R1-position, strongly activated hPXR at 300 microM.	Hydantoins	15-25	nuclear receptor subfamily 1 group I member 2	Homo sapiens	122-126
15039302-10	2004	These results suggest that the presence of an alkyl-chain at the R1-position and the presence of bulky and hydrophobic moieties at both R2- and R3-positions are important factors for activation of hPXR by hydantoins.	Hydantoins	205-215	nuclear receptor subfamily 1 group I member 2	Homo sapiens	197-201
12504329-3	2003	A photoactive hydantoin analog specifically labels an amino acid residue of LFA-1 I domain.	Hydantoins	14-23	integrin subunit alpha L	Homo sapiens	76-81
12504329-6	2003	The results demonstrate specific, stoichiometric, reversible binding of the hydantoins to LFA-1.	Hydantoins	76-86	integrin subunit alpha L	Homo sapiens	90-95
11720851-0	2001	Discovery of human CCR5 antagonists containing hydantoins for the treatment of HIV-1 infection.	Hydantoins	47-57	C-C motif chemokine receptor 5	Homo sapiens	19-23
11720851-1	2001	A series of hydantoin derivatives has been discovered as highly potent nonpeptide antagonists for the human CCR5 receptor.	Hydantoins	12-21	C-C motif chemokine receptor 5	Homo sapiens	108-112
11720852-1	2001	Replacement of the large hydantoin-indole moiety from our previous work with a variety of smaller heterocyclic analogues gave rise to potent CCR5 antagonists having binding affinity comparable to the hydantoin analogues.	Hydantoins	25-34	C-C motif chemokine receptor 5	Homo sapiens	141-145
8825077-1	1995	A lower microsomal epoxide hydrolase (mEH) activity has been associated with increased likelihood of fetal hydantoin syndrome.	Hydantoins	107-116	epoxide hydrolase 1, microsomal	Mus musculus	8-36
11403595-0	2001	Binding site elucidation of hydantoin-based antagonists of LFA-1 using multidisciplinary technologies: evidence for the allosteric inhibition of a protein--protein interaction.	Hydantoins	28-37	integrin subunit alpha L	Homo sapiens	59-64
11403595-1	2001	The binding site on the lymphocyte function-associated antigen-1 (LFA-1) of a class of hydantoin-based antagonists of leukocyte cell adhesion has been identified.	Hydantoins	87-96	integrin subunit alpha L	Homo sapiens	24-64
11403595-1	2001	The binding site on the lymphocyte function-associated antigen-1 (LFA-1) of a class of hydantoin-based antagonists of leukocyte cell adhesion has been identified.	Hydantoins	87-96	integrin subunit alpha L	Homo sapiens	66-71
11312916-0	2001	Discovery of an orally active non-peptide fibrinogen receptor antagonist based on the hydantoin scaffold.	Hydantoins	86-95	fibrinogen beta chain	Homo sapiens	42-52
8767112-2	1996	It has been shown that the investigated derivatives are recognized by 5-HT1A and 5-HT2A receptors due to the presence of a 1-arylpiperazine fragment however, the terminal hydantoin moiety plays an important role in stabilization of the receptor-ligand complex.	Hydantoins	171-180	5-hydroxytryptamine receptor 1A	Homo sapiens	70-82
8767112-2	1996	It has been shown that the investigated derivatives are recognized by 5-HT1A and 5-HT2A receptors due to the presence of a 1-arylpiperazine fragment however, the terminal hydantoin moiety plays an important role in stabilization of the receptor-ligand complex.	Hydantoins	171-180	5-hydroxytryptamine receptor 2A	Homo sapiens	83-87
11693932-3	2001	Hydantoinase and N-carbamoylamino acid amidohydrolase (NCAAH) activities are induced when cells are grown in the presence of hydantoin or an hydantoin analogue, and in complete medium, enzyme activity can be detected only in early stationary growth phase.	Hydantoins	125-134	AWN88_RS03840	Agrobacterium tumefaciens	0-12
11693932-3	2001	Hydantoinase and N-carbamoylamino acid amidohydrolase (NCAAH) activities are induced when cells are grown in the presence of hydantoin or an hydantoin analogue, and in complete medium, enzyme activity can be detected only in early stationary growth phase.	Hydantoins	141-150	AWN88_RS03840	Agrobacterium tumefaciens	0-12
11300910-2	2001	The rate-surfactant profiles for the HO(-)- and AcO(-)-catalyzed ring closure of two ethyl hydantoates, E2 and E3, to hydantoins with three cetyltrimethylammonium salts (CTAX, X = Br(-), Cl(-), or AcO(-)) are measured in 0.02 and 0.2 M acetate buffers 50% base with starting pH 4.65.	Hydantoins	118-128	cystatin 12, pseudogene	Homo sapiens	104-113
10328974-6	1999	Aldose reductase inhibitors possessing either hydantoin or carboxylic acid groups prevented protein modification induced by naphthalene-1, 2-dihydrodiol but not protein modification induced by 1, 2-dihydroxynaphthalene or 1,2-naphthoquinone.	Hydantoins	46-55	aldo-keto reductase family 1 member B1	Rattus norvegicus	0-16
9579068-1	1998	D-Amino acids, important intermediates in the production of semisynthetic penicillins and cephalosporins, are currently prepared from the corresponding hydantoins using bacterial biomass containing two enzymes, hydantoinase and carbamylase.	Hydantoins	152-162	AWN88_RS03840	Agrobacterium tumefaciens	211-223
8825077-1	1995	A lower microsomal epoxide hydrolase (mEH) activity has been associated with increased likelihood of fetal hydantoin syndrome.	Hydantoins	107-116	epoxide hydrolase 1, microsomal	Mus musculus	38-41
7562906-2	1995	Variation of substituents on the hydantoin ring leads to potent and selective Ang II antagonists with nanomolar IC50 values at the AT1 receptor and negligible affinity for the AT2 receptor.	Hydantoins	33-42	angiotensinogen	Rattus norvegicus	78-84
7578956-1	1995	The crystal structure of the hydantoin 1-[(S)-1"-aminoethylmalonyl benzyl ester]-(S)-4-methylimidazolidin-2,5-dione (1) derived from the peptide H-Ala-gAla-mGly-OBzl, having the retro-inverso modification of the Ala-Gly bond, has been determined by x-ray diffraction analysis.	Hydantoins	29-38	galactosidase alpha	Homo sapiens	151-155
7562906-2	1995	Variation of substituents on the hydantoin ring leads to potent and selective Ang II antagonists with nanomolar IC50 values at the AT1 receptor and negligible affinity for the AT2 receptor.	Hydantoins	33-42	angiotensin II receptor, type 1a	Rattus norvegicus	131-134
2079641-2	1990	Derivatives of hydantoin have been found to inactivate human leukocyte elastase irreversibly.	Hydantoins	15-24	elastase, neutrophil expressed	Homo sapiens	61-79
8035330-3	1994	The serum concentrations associated with half-maximal hepatic CYP2B induction (EC50 values) were 6 to 11 microM and 15 to 18 microM for the diphenyl-substituted barbiturate and hydantoin, respectively, based on measurement of pentoxy- or benzyloxyresorufin O-dealkylation activities, or immunoreactive CYP2B1 protein.	Hydantoins	177-186	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	302-308
1613744-2	1992	The hypothesis that clinical side effects of the aldose reductase inhibitor (ARI) sorbinil were related to its hydantoin ring led to a bioisosteric analysis and replacement of the hydantoin by a spiro hydroxy acetic acid moiety as in 40.	Hydantoins	111-120	aldo-keto reductase family 1 member B1	Rattus norvegicus	49-65
1613744-2	1992	The hypothesis that clinical side effects of the aldose reductase inhibitor (ARI) sorbinil were related to its hydantoin ring led to a bioisosteric analysis and replacement of the hydantoin by a spiro hydroxy acetic acid moiety as in 40.	Hydantoins	180-189	aldo-keto reductase family 1 member B1	Rattus norvegicus	49-65
2128352-0	1990	Effects of novel hydantoin derivatives with aldose reductase inhibiting activity on galactose-induced cataract in rats.	Hydantoins	17-26	aldo-keto reductase family 1 member B1	Rattus norvegicus	44-60
2113948-1	1990	A series of spiro hydantoins derived from 8-azachromanones (2,3-dihydro-4H-pyrano[2,3-b]pyridin-4-ones) has been prepared and tested for aldose reductase inhibitory activity.	Hydantoins	18-28	aldo-keto reductase family 1 member B	Homo sapiens	137-153
7658443-2	1995	Structural modifications of N- and C-linked (principally hydantoin) analogues at the 5-position were synthesized and their pharmacological activities were utilized to deduce significant steric and electrostatic requirements of the 5-HT1D and 5-HT2A receptor subtypes.	Hydantoins	57-66	5-hydroxytryptamine receptor 1D	Homo sapiens	231-237
7658443-2	1995	Structural modifications of N- and C-linked (principally hydantoin) analogues at the 5-position were synthesized and their pharmacological activities were utilized to deduce significant steric and electrostatic requirements of the 5-HT1D and 5-HT2A receptor subtypes.	Hydantoins	57-66	5-hydroxytryptamine receptor 2A	Homo sapiens	242-248
3378426-8	1988	Aqueous solutions of (D)MDM hydantoin in concentrations as used in cosmetic products therefore contain enough free formaldehyde to cause dermatitis in a patch test system in some formaldehyde-allergic patients: 12 such patients applied a cream containing 1% DMDM hydantoin to the flexor aspect of the lower arm twice daily for 1 week; 4 (33%) developed dermatitis.	Hydantoins	28-37	secreted LY6/PLAUR domain containing 1	Homo sapiens	24-27
34648230-0	2021	Structure-Activity Relationship Studies of Hydantoin-Cored Ligands for Smoothened Receptor.	Hydantoins	43-52	smoothened, frizzled class receptor	Homo sapiens	71-90
3425630-0	1987	Elevated glucocorticoid receptor levels in lymphocytes of children with the fetal hydantoin syndrome (FHS).	Hydantoins	82-91	nuclear receptor subfamily 3 group C member 1	Homo sapiens	9-32
3121857-2	1988	Spiro hydantoins derived from five- and six-membered ketones fused to an aromatic ring or ring system inhibit aldose reductase isolated from calf lens.	Hydantoins	6-16	aldose reductase	Bos taurus	110-126
3115267-0	1987	Development of potent aldose reductase inhibitors having a hydantoin structure.	Hydantoins	59-68	aldo-keto reductase family 1 member B1	Rattus norvegicus	22-38
3115267-1	1987	Seventeen hydantoin derivatives were tested as inhibitors of aldose reductase, an enzyme believed to participate in the initiation of diabetic complications.	Hydantoins	10-19	aldo-keto reductase family 1 member B1	Rattus norvegicus	61-77
32505850-6	2020	Hydantoin derivatives (5-7) were significantly more effective than the reference inhibitor verapamil (up to 2.6-fold at a 10-fold lower concentration) modulating ABCB1-efflux pump, also possessing a good drug-drug interaction profile.	Hydantoins	0-9	ATP binding cassette subfamily B member 1	Homo sapiens	162-167
3989820-1	1985	Selectively substituted hydantoins 1 (15 examples), 4-hydroxy-2-imidazolidinones 2 (13 examples), 2-imidazolones 3 (10 examples), 2-imidazolidinones 4 (four examples), vicinal diamines 5 (two examples), and simple amino acid derivatives 6 (four examples) have been prepared and evaluated in the maximal electroshock seizure (MES), subcutaneous pentylenetetrazole seizure threshold (sc Met), and rotorod (Tox) tests.	Hydantoins	24-34	thymocyte selection associated high mobility group box	Homo sapiens	404-407
6087417-8	1984	The hydantoin acts at the platelet PGD2 receptor.	Hydantoins	4-13	prostaglandin D2 receptor	Homo sapiens	35-48
6302737-0	1983	Pharmacological and cardiovascular properties of a hydantoin derivative, BW 245 C, with high affinity and selectivity for PGD2 receptors.	Hydantoins	51-60	prostaglandin D2 synthase	Homo sapiens	122-126
90139-4	1979	The most pronounced changes in IgA levels were seen in patients in whom the hydantoin medication also changed.	Hydantoins	76-85	CD79a molecule	Homo sapiens	31-34
650410-2	1978	Binding of some salicylates and hydantoin derivatives to bovine serum albumin by fluorescent probe technique (author"s transl)].	Hydantoins	32-41	albumin	Homo sapiens	64-77
1244103-2	1975	Under the treatment with antiepileptic drugs, especially with hydantoin and succinimide a depression of the activity of EGOT and the level of pyridoxal-phosphate in serum followed.	Hydantoins	62-71	eosinophil granule ontogeny transcript	Homo sapiens	120-124
4369857-2	1974	The hydantoins released on hydrolysis of HCN oligomers.	Hydantoins	4-14	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	41-44
33719441-4	2021	We describe the discovery of GLPG1972/S201086, a potent and selective ADAMTS-5 inhibitor obtained by optimization of a promising hydantoin series following an HTS.	Hydantoins	129-138	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	70-78
4150990-0	1974	The role of dihydropyrimidinase in the metabolism of some hydantoin and succinimide drugs.	Hydantoins	58-67	dihydropyrimidinase	Homo sapiens	12-31
32069022-5	2020	The 2"-F-hydantoins in duplex DNA were found to be highly resistant to the glycosylase activity of Fpg and NEIL1 compared to the unmodified lesion substrates.	Hydantoins	4-19	nei like DNA glycosylase 1	Homo sapiens	107-112
32302101-0	2020	Inhibition of Excison of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.	Hydantoins	47-56	nei like DNA glycosylase 1	Homo sapiens	72-77
32302101-0	2020	Inhibition of Excison of Oxidatively Generated Hydantoin DNA Lesions by NEIL1 by the Competitive Binding of the Nucleotide Excision Repair Factor XPC-RAD23B.	Hydantoins	47-56	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	146-156
31944122-0	2020	Ullmann-type C-Se cross-coupling in the hydantoin family: Synthesis, mechanistic studies, and tests of biological activity.	Hydantoins	40-49	choreoathetosis/spasticity, episodic (paroxysmal choreoathetosis/spasticity)	Homo sapiens	13-17
32105280-0	2020	Interaction of hydantoin with solar wind minority ions: O6+ and He2.	Hydantoins	15-24	sperm associated antigen 11A	Homo sapiens	64-67
30969473-6	2019	To explore the relationships between molecular structures and corresponding binding abilities to aid the new AR modulator design, multiple linear regressions (MLR) are employed to analyze a series of hydantoin analogues, which can bind to androgen receptor acting as AR modulators.	Hydantoins	200-209	androgen receptor	Homo sapiens	109-111
31744675-3	2020	The present study examined the AR inhibitory effects of novel synthetic hydantoins and their structural relatives, some of which were obtained from chemically engineered extracts of natural plants, and discovered several novel AR inhibitors with moderate inhibitory activity.	Hydantoins	72-82	aldo-keto reductase family 1 member B	Homo sapiens	31-33
31744675-3	2020	The present study examined the AR inhibitory effects of novel synthetic hydantoins and their structural relatives, some of which were obtained from chemically engineered extracts of natural plants, and discovered several novel AR inhibitors with moderate inhibitory activity.	Hydantoins	72-82	aldo-keto reductase family 1 member B	Homo sapiens	227-229
30969473-6	2019	To explore the relationships between molecular structures and corresponding binding abilities to aid the new AR modulator design, multiple linear regressions (MLR) are employed to analyze a series of hydantoin analogues, which can bind to androgen receptor acting as AR modulators.	Hydantoins	200-209	androgen receptor	Homo sapiens	239-256
30969473-6	2019	To explore the relationships between molecular structures and corresponding binding abilities to aid the new AR modulator design, multiple linear regressions (MLR) are employed to analyze a series of hydantoin analogues, which can bind to androgen receptor acting as AR modulators.	Hydantoins	200-209	androgen receptor	Homo sapiens	267-269
31840594-6	2019	The cell migration index and expression level of tumor invasion-promoting metalloproteinase- 9 (MMP-9) gene were significantly decreased after treatment with the tested hydantoin derivatives implicating their inhibitory role in colon cancer cell motility and invasion processes.	Hydantoins	169-178	matrix metallopeptidase 9	Homo sapiens	96-101
31413795-0	2019	Design, Synthesis, and Biological Evaluation of 2,4-Imidazolinedione Derivatives as HDAC6 Isoform-Selective Inhibitors.	Hydantoins	48-68	histone deacetylase 6	Homo sapiens	84-89
31413795-2	2019	Herein, we reported a series of 2,4-imidazolinedione derivatives as novel HDAC6 isoform-selective inhibitors based on structure-based drug design.	Hydantoins	32-52	histone deacetylase 6	Homo sapiens	74-79
30614708-4	2019	This synthetic strategy is user friendly as CBX is a bench-stable easy-to-handle crystalline reagent and avoids conventional multistep protocols, thus allowing the facile synthesis of a library of chiral hydantoins.	Hydantoins	204-214	chromobox 1	Homo sapiens	44-47
29126741-1	2017	A series of novel hydantoin-bridged analogues of combretastatin A-4 (CA-4) were designed, synthesized and evaluated for antiproliferative activities in vitro and in vivo.	Hydantoins	18-27	carbonic anhydrase 4	Homo sapiens	49-67
29500402-9	2018	However, we further found that phenytoin attenuated RIPK1 kinase activity in vitro, likely due to the hydantoin scaffold also present in necrostatin-1, and blocked upstream necrosome formation steps in the cells undergoing necroptosis.	Hydantoins	102-111	receptor interacting serine/threonine kinase 1	Homo sapiens	52-57
29227678-4	2018	A hydantoin-bearing submicromolar primary hit acting as an Aurora kinase A inhibitor was discovered with a combination of rational design, parallel synthesis using the procedures developed, in silico and in vitro screenings.	Hydantoins	2-11	aurora kinase A	Homo sapiens	59-74
29126741-1	2017	A series of novel hydantoin-bridged analogues of combretastatin A-4 (CA-4) were designed, synthesized and evaluated for antiproliferative activities in vitro and in vivo.	Hydantoins	18-27	carbonic anhydrase 4	Homo sapiens	69-73
27151486-8	2016	Molecular docking study performed for two hydantoins with the highest bioavailability scores shows high binding affinity to tyrosine kinase receptor IGF-1R.	Hydantoins	42-52	insulin like growth factor 1 receptor	Homo sapiens	149-155
28711352-0	2017	Development of a prodrug of hydantoin based TACE inhibitor.	Hydantoins	28-37	ADAM metallopeptidase domain 17	Homo sapiens	44-48
28711352-1	2017	Our research on hydantoin based TNF-alpha converting enzyme (TACE) inhibitors led to fused bi-heteroaryl hydantoin series that demonstrate sub-nanomolar potency (Ki) as well as excellent activity in human whole blood (hWBA).	Hydantoins	16-25	ADAM metallopeptidase domain 17	Homo sapiens	32-59
28711352-1	2017	Our research on hydantoin based TNF-alpha converting enzyme (TACE) inhibitors led to fused bi-heteroaryl hydantoin series that demonstrate sub-nanomolar potency (Ki) as well as excellent activity in human whole blood (hWBA).	Hydantoins	16-25	ADAM metallopeptidase domain 17	Homo sapiens	61-65
28558971-0	2017	Fused bi-heteroaryl substituted hydantoin compounds as TACE inhibitors.	Hydantoins	32-41	ADAM metallopeptidase domain 17	Homo sapiens	55-59
28558971-1	2017	We have identified a series of hydantoin-derived TNF-a converting enzyme (TACE) inhibitors containing a pendant fused bi-heteroaryl group, which demonstrate sub-nanomolar potency (Ki), excellent activity in human whole blood assay, and improved DMPK profiles over prior series.	Hydantoins	31-40	ADAM metallopeptidase domain 17	Homo sapiens	49-72
28613895-0	2017	A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.	Hydantoins	19-28	ADAM metallopeptidase with thrombospondin type 1 motif 4	Homo sapiens	42-55
28613895-0	2017	A Highly Selective Hydantoin Inhibitor of Aggrecanase-1 and Aggrecanase-2 with a Low Projected Human Dose.	Hydantoins	19-28	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	60-73
27933964-5	2016	The principal SAR insight was that the hydantoin core of 1 is required for high antischistosomal activity.	Hydantoins	39-48	sarcosine dehydrogenase	Homo sapiens	14-17
27283790-4	2016	We revealed that a combination of our newly developed linker and hydantoin (54) plays a pivotal role in improving the potency and selectivity of LXRbeta.	Hydantoins	65-74	nuclear receptor subfamily 1, group H, member 2	Mus musculus	145-152
28558971-1	2017	We have identified a series of hydantoin-derived TNF-a converting enzyme (TACE) inhibitors containing a pendant fused bi-heteroaryl group, which demonstrate sub-nanomolar potency (Ki), excellent activity in human whole blood assay, and improved DMPK profiles over prior series.	Hydantoins	31-40	ADAM metallopeptidase domain 17	Homo sapiens	74-78
28558971-1	2017	We have identified a series of hydantoin-derived TNF-a converting enzyme (TACE) inhibitors containing a pendant fused bi-heteroaryl group, which demonstrate sub-nanomolar potency (Ki), excellent activity in human whole blood assay, and improved DMPK profiles over prior series.	Hydantoins	31-40	DM1 protein kinase	Homo sapiens	245-249
27009905-0	2016	Plasmin inhibitors with hydrophobic amino acid-based linker between hydantoin moiety and benzimidazole scaffold enhance inhibitory activity.	Hydantoins	68-77	plasminogen	Homo sapiens	0-7
27009905-1	2016	In this letter we report the design and synthesis of a series of plasmin inhibitors, which share the amino acid-based linker with limited free rotation between the hydantoin moiety and the benzimidazole scaffold.	Hydantoins	164-173	plasminogen	Homo sapiens	65-72
25813041-4	2015	Also, the NEIL1 and NEIL3 DNA glycosylases can remove hydantoin lesions but none of the glycosylases, including OGG1, are able to remove 8-oxoG from telomeric quadruplexes.	Hydantoins	54-63	nei like DNA glycosylase 1	Homo sapiens	10-15
25813041-4	2015	Also, the NEIL1 and NEIL3 DNA glycosylases can remove hydantoin lesions but none of the glycosylases, including OGG1, are able to remove 8-oxoG from telomeric quadruplexes.	Hydantoins	54-63	nei like DNA glycosylase 3	Homo sapiens	20-25
25813041-6	2015	However, NEIL1, NEIL2 and NEIL3 remove hydantoins from telomeric quadruplexes formed by five TTAGGG repeats much more rapidly than the commonly studied four-repeat quadruplex structures.	Hydantoins	39-49	nei like DNA glycosylase 1	Homo sapiens	9-14
25813041-6	2015	However, NEIL1, NEIL2 and NEIL3 remove hydantoins from telomeric quadruplexes formed by five TTAGGG repeats much more rapidly than the commonly studied four-repeat quadruplex structures.	Hydantoins	39-49	nei like DNA glycosylase 2	Homo sapiens	16-21
25813041-6	2015	However, NEIL1, NEIL2 and NEIL3 remove hydantoins from telomeric quadruplexes formed by five TTAGGG repeats much more rapidly than the commonly studied four-repeat quadruplex structures.	Hydantoins	39-49	nei like DNA glycosylase 3	Homo sapiens	26-31
25580690-3	2015	The hydantoin, 3-phenyl-5-(4-ethylphenyl)-imidazolidine-2,4-dione (IM-3), synthesized from the amino acid, glycine, was selected for psychopharmacological studies in mice on the basis of its chemical and structural similarity with phenytoin.	Hydantoins	4-13	immunoregulatory 3	Mus musculus	67-71
25415648-0	2014	Identification of potent and selective hydantoin inhibitors of aggrecanase-1 and aggrecanase-2 that are efficacious in both chemical and surgical models of osteoarthritis.	Hydantoins	39-48	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	63-76
25415648-4	2014	A series of hydantoin inhibitors of ADAMTS-4 and ADAMTS-5 were identified from a screening campaign and optimized through structure-based drug design to give hydantoin 13.	Hydantoins	12-21	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	36-44
25415648-4	2014	A series of hydantoin inhibitors of ADAMTS-4 and ADAMTS-5 were identified from a screening campaign and optimized through structure-based drug design to give hydantoin 13.	Hydantoins	12-21	ADAM metallopeptidase with thrombospondin type 1 motif, 5	Rattus norvegicus	49-57
25415648-4	2014	A series of hydantoin inhibitors of ADAMTS-4 and ADAMTS-5 were identified from a screening campaign and optimized through structure-based drug design to give hydantoin 13.	Hydantoins	158-167	ADAM metallopeptidase with thrombospondin type 1 motif, 4	Rattus norvegicus	36-44
25415648-4	2014	A series of hydantoin inhibitors of ADAMTS-4 and ADAMTS-5 were identified from a screening campaign and optimized through structure-based drug design to give hydantoin 13.	Hydantoins	158-167	ADAM metallopeptidase with thrombospondin type 1 motif, 5	Rattus norvegicus	49-57
25372819-2	2014	Allantoinase catalyzes the reversible hydrolysis of allantoin into allantoate by hydrolytic cleavage of the N1-C2 amide bond of the five-membered hydantoin ring.	Hydantoins	146-155	allantoinase AllB	Bacillus licheniformis DSM 13 = ATCC 14580	0-12
25173590-1	2014	Two series of 6,7-disubstituted-4-phenoxyquinoline derivatives bearing 2,4-imidazolinedione/pyrazolone scaffold were designed, synthesized and evaluated for their c-Met kinase inhibition and cytotoxicity against HT-29, H460, A549, MKN-45, and U87MG cancer cell lines in vitro.	Hydantoins	71-91	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	163-168
23755964-5	2013	GD NEIL3 excised the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in single-stranded (ss) and double-stranded (ds) DNA efficiently.	Hydantoins	21-30	nei like DNA glycosylase 3	Homo sapiens	3-8
24660679-9	2014	Additionally, the hydantoin ring of 66 is able to interact by hydrogen bonds with two conserved water molecules in the MAO-A active site, while the methyl-thiohydantoin ring of 68 is within hydrogen bond distance from the hydrogen atom attached to the (N-5) of FAD cofactor.	Hydantoins	18-27	monoamine oxidase A	Homo sapiens	119-124
23810497-0	2013	Hydantoin based inhibitors of MMP13--discovery of AZD6605.	Hydantoins	0-9	matrix metallopeptidase 13	Rattus norvegicus	30-35
22381672-1	2012	An association between alpha(1)-adrenoceptor affinities, hERG K(+)-antagonistic properties and antiarrhythmic activities for a series of phenylpiperazine derivatives of hydantoin (2a-21a) was investigated.	Hydantoins	169-178	ETS transcription factor ERG	Homo sapiens	57-61
23305905-0	2013	Loss of Neil3, the major DNA glycosylase activity for removal of hydantoins in single stranded DNA, reduces cellular proliferation and sensitizes cells to genotoxic stress.	Hydantoins	65-75	nei like 3 (E. coli)	Mus musculus	8-13
23305905-4	2013	The mammalian endonuclease VIII-like 3 (Neil3) is one of the four DNA glycosylases found to recognize and remove hydantoins in the first step of base excision repair (BER) pathway.	Hydantoins	113-123	nei like DNA glycosylase 3	Homo sapiens	14-38
23305905-4	2013	The mammalian endonuclease VIII-like 3 (Neil3) is one of the four DNA glycosylases found to recognize and remove hydantoins in the first step of base excision repair (BER) pathway.	Hydantoins	113-123	nei like DNA glycosylase 3	Homo sapiens	40-45
23305905-5	2013	We have generated mice lacking Neil3 and by using total cell extracts we demonstrate that Neil3 is the main DNA glycosylase that incises hydantoins in single stranded DNA in tissues.	Hydantoins	137-147	nei like 3 (E. coli)	Mus musculus	31-36
23305905-5	2013	We have generated mice lacking Neil3 and by using total cell extracts we demonstrate that Neil3 is the main DNA glycosylase that incises hydantoins in single stranded DNA in tissues.	Hydantoins	137-147	nei like 3 (E. coli)	Mus musculus	90-95
22897611-1	2012	A novel selective androgen receptor modulator scaffold has been discovered through structural modifications of hydantoin antiandrogens.	Hydantoins	111-120	androgen receptor	Rattus norvegicus	18-35
23543430-4	2013	Small-molecule BACE1 inhibitors of the hydroxyethylamine, hydantoin, and sulfamide classes were functionalized by biotin PEG linkers of varying lengths forming probes that were bound to streptavidin donor beads.	Hydantoins	58-67	beta-secretase 1	Homo sapiens	15-20
23543430-7	2013	A probe from the hydantoin class was chosen for further optimization, where the final assay conditions of 50 nM BACE and 250 nM probe were used and Z(") values >0.75 were commonly observed.	Hydantoins	17-26	beta-secretase 1	Homo sapiens	112-116
23117589-5	2012	The difference in potencies of hydantoin and piperazinedione analogues, together with the necessity of C-5/C-6 R-absolute configuration has been revealed through molecular docking.	Hydantoins	31-40	complement C5	Homo sapiens	103-106
23117589-5	2012	The difference in potencies of hydantoin and piperazinedione analogues, together with the necessity of C-5/C-6 R-absolute configuration has been revealed through molecular docking.	Hydantoins	31-40	complement C6	Homo sapiens	107-110
22959434-3	2012	In mice, Neil3 is the main DNA glycosylase for repair of hydantoin lesions in single-stranded DNA of neural stem/progenitor cells, promoting neurogenesis.	Hydantoins	57-66	nei like 3 (E. coli)	Mus musculus	9-14
21696967-0	2011	The discovery of long-acting saligenin beta2 adrenergic receptor agonists incorporating hydantoin or uracil rings.	Hydantoins	88-97	adrenoceptor beta 2	Rattus norvegicus	39-64
21965738-2	2011	Previously, we demonstrated that eight hydantoin derivatives inhibited the P-glycoprotein (ABCB1) efflux pump of mouse T-lymphoma cells, as well as acting synergistically with the anticancer drug doxorubicin.	Hydantoins	39-48	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	91-96
21737263-2	2011	A novel series of potent bicyclic hydantoin Smo antagonists was reported in the preceding article, these have been resolved, and optimized to identify potent homochiral derivatives with clean off-target profiles and good pharmacokinetic properties in preclinical species.	Hydantoins	34-43	smoothened, frizzled class receptor	Homo sapiens	44-47
22351672-0	2012	Activity of fourteen new hydantoin compounds on the human ABCB1 efflux pump.	Hydantoins	25-34	ATP binding cassette subfamily B member 1	Homo sapiens	58-63
22351672-3	2012	Previously it was observed that hydantoin compounds can modulate the activity of the ABCB1 pump.	Hydantoins	32-41	ATP binding cassette subfamily B member 1	Homo sapiens	85-90
22351672-4	2012	MATERIALS AND METHODS: Fourteen hydantoin derivatives were synthesized and studied for their capacity to increase accumulation of ethidium bromide (EB) by mouse lymphoma cancer cells that were transfected with the human ABCB1 gene and overexpress the human ABCB1 pump.	Hydantoins	32-41	ATP binding cassette subfamily B member 1	Homo sapiens	220-225
21671576-3	2011	The combination of a recognized privileged scaffold (hydantoin) and a functional group with high incidence in bioactive molecules (guanidine) guided the design of a library of amphipatic compounds, which allowed the discovery of novel TRPV1 ion channel blockers.	Hydantoins	53-62	transient receptor potential cation channel subfamily V member 1	Homo sapiens	235-240
21696967-1	2011	A series of novel, potent and selective human beta(2) adrenoceptor agonists incorporating a hydantoin or a uracil ring on the right-hand side phenyl ring of (R)-salmeterol is presented.	Hydantoins	92-101	adrenoceptor beta 2	Homo sapiens	46-66
20386016-1	2010	RO5068760, a substituted hydantoin, represents a new class of potent, highly selective, non-adenosine triphosphate (ATP)-competitive MEK1/2 inhibitors.	Hydantoins	25-34	mitogen-activated protein kinase kinase 1	Homo sapiens	133-139
21799731-10	2011	Importantly, a number of redundant DNA glycosylase activities can excise hydantoin residues, including human NTH1, NEIL1 and NEIL2 and the former protein being a major DNA glycosylase activity in HeLa cells extracts.	Hydantoins	73-82	nth like DNA glycosylase 1	Homo sapiens	109-113
21799731-10	2011	Importantly, a number of redundant DNA glycosylase activities can excise hydantoin residues, including human NTH1, NEIL1 and NEIL2 and the former protein being a major DNA glycosylase activity in HeLa cells extracts.	Hydantoins	73-82	nei like DNA glycosylase 1	Homo sapiens	115-120
21799731-10	2011	Importantly, a number of redundant DNA glycosylase activities can excise hydantoin residues, including human NTH1, NEIL1 and NEIL2 and the former protein being a major DNA glycosylase activity in HeLa cells extracts.	Hydantoins	73-82	nei like DNA glycosylase 2	Homo sapiens	125-130
21187464-0	2010	Biological activity of hydantoin derivatives on P-glycoprotein (ABCB1) of mouse lymphoma cells.	Hydantoins	23-32	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	64-69
21187464-8	2010	CONCLUSION: These results indicated the role of chemical modifications within the hydantoin ring for its potential inhibition of the ABCB1 transporter.	Hydantoins	82-91	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	133-138
21441024-1	2011	A new series of IGF-1R inhibitors related to hydantoins were identified from a lead originating from HTS.	Hydantoins	45-55	insulin like growth factor 1 receptor	Homo sapiens	16-22
21106451-1	2010	Our research on hydantoin based TNF-alpha converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood.	Hydantoins	16-25	ADAM metallopeptidase domain 17	Homo sapiens	32-59
21106451-1	2010	Our research on hydantoin based TNF-alpha converting enzyme (TACE) inhibitors has led to an acetylene containing series that demonstrates sub-nanomolar potency (K(i)) as well as excellent activity in human whole blood.	Hydantoins	16-25	ADAM metallopeptidase domain 17	Homo sapiens	61-65