PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
27332705-4	2016	In this study, we characterised the functional properties of the major anxiolytic kavalactone, kavain at human recombinant alpha1beta2, beta2gamma2L, alphaxbeta2gamma2L (x = 1, 2, 3 and 5), alpha1betaxgamma2L (x = 1, 2 and 3) and alpha4beta2delta GABAARs expressed in Xenopus oocytes using the two-electrode voltage clamp technique.	kavain	95-101	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	150-187
27332705-4	2016	In this study, we characterised the functional properties of the major anxiolytic kavalactone, kavain at human recombinant alpha1beta2, beta2gamma2L, alphaxbeta2gamma2L (x = 1, 2, 3 and 5), alpha1betaxgamma2L (x = 1, 2 and 3) and alpha4beta2delta GABAARs expressed in Xenopus oocytes using the two-electrode voltage clamp technique.	kavain	95-101	xenotropic and polytropic retrovirus receptor 1	Homo sapiens	190-224
11170221-9	2001	Remarkably, the MPTP-induced decrease of TH-immunoreactivity as well as the loss of nigral neurons was completely prevented by (+/-)-kavain (200 mg/kg).	kavain	127-139	tyrosine hydroxylase	Mus musculus	41-43
19538508-7	2009	Interestingly, a ring-opened analog of kavain inhibited TNF-alpha secretion in the cell-based assay and suppressed lipopolysaccharide-induced TNF-alpha factor expression in the same cells, whereas the other compounds inhibited TNF-alpha secretion without affecting lipopolysaccharide-induced TNF-alpha factor levels, indicating a potential divergence in mechanism of action.	kavain	39-45	tumor necrosis factor	Homo sapiens	56-65
19538508-7	2009	Interestingly, a ring-opened analog of kavain inhibited TNF-alpha secretion in the cell-based assay and suppressed lipopolysaccharide-induced TNF-alpha factor expression in the same cells, whereas the other compounds inhibited TNF-alpha secretion without affecting lipopolysaccharide-induced TNF-alpha factor levels, indicating a potential divergence in mechanism of action.	kavain	39-45	tumor necrosis factor	Homo sapiens	142-151
19538508-7	2009	Interestingly, a ring-opened analog of kavain inhibited TNF-alpha secretion in the cell-based assay and suppressed lipopolysaccharide-induced TNF-alpha factor expression in the same cells, whereas the other compounds inhibited TNF-alpha secretion without affecting lipopolysaccharide-induced TNF-alpha factor levels, indicating a potential divergence in mechanism of action.	kavain	39-45	tumor necrosis factor	Homo sapiens	142-151
19538508-7	2009	Interestingly, a ring-opened analog of kavain inhibited TNF-alpha secretion in the cell-based assay and suppressed lipopolysaccharide-induced TNF-alpha factor expression in the same cells, whereas the other compounds inhibited TNF-alpha secretion without affecting lipopolysaccharide-induced TNF-alpha factor levels, indicating a potential divergence in mechanism of action.	kavain	39-45	tumor necrosis factor	Homo sapiens	142-151
32550490-0	2020	Kavain suppresses human Abeta-induced paralysis in C. elegans.	kavain	0-6	amyloid beta precursor protein	Homo sapiens	24-29
35278473-9	2022	However, uncertainty around kavalactone exposure in humans has been noted and a clinically relevant CES1 inhibition by kavain, dihydrokavain, and dihydromethysticin is indeed possible if the kavalactone consumption is higher than 1000 mg in the context of over-the-counter usage.	kavain	119-125	carboxylesterase 1	Homo sapiens	100-104
31233340-5	2019	This compound further screened by applying molecular docking simulation identified five potential hits such as osthole, kavain, vanillyl acetone, myristicin, and psoralen, having a comparable binding affinity to COX-2 protein.	kavain	120-126	prostaglandin-endoperoxide synthase 2	Homo sapiens	212-217
31233340-6	2019	However, in cell experiment, three hit compounds revealed COX-2 inhibitory activity in mRNA and protein level such as osthole, kavain, and psoralen.	kavain	127-133	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-63
30078210-0	2018	Modulating calcium-mediated NFATc1 and mitogen-activated protein kinase deactivation underlies the inhibitory effects of kavain on osteoclastogenesis and bone resorption.	kavain	121-127	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	28-34
30078210-9	2018	Additionally, kavain repressed RANKL-induced calcium oscillations, nuclear factor of activated T cells activation, and mitogen-activated protein kinase phosphorylation, while leaving NF-kappaB unaffected.	kavain	14-20	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	31-36
30078210-9	2018	Additionally, kavain repressed RANKL-induced calcium oscillations, nuclear factor of activated T cells activation, and mitogen-activated protein kinase phosphorylation, while leaving NF-kappaB unaffected.	kavain	14-20	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 1	Mus musculus	67-102
31539917-3	2019	(+-)-Kavain was found to be a good potency in vitro inhibitor of human MAO-B with an IC50 of 5.34 microM.	kavain	5-11	monoamine oxidase B	Homo sapiens	71-76
31539917-4	2019	(+-)-Kavain is a weaker MAO-A inhibitor with an IC50 of 19.0 microM.	kavain	5-11	monoamine oxidase A	Homo sapiens	24-29
31539917-6	2019	It was further established that (+-)-kavain interacts reversibly and competitively with MAO-A and MAO-B with enzyme-inhibitor dissociation constants (Ki) of 7.72 and 5.10 microM, respectively.	kavain	37-43	monoamine oxidase A	Homo sapiens	88-93
31539917-6	2019	It was further established that (+-)-kavain interacts reversibly and competitively with MAO-A and MAO-B with enzyme-inhibitor dissociation constants (Ki) of 7.72 and 5.10 microM, respectively.	kavain	37-43	monoamine oxidase B	Homo sapiens	98-103