PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29996653-6	2018	Based on the in vitro skin irritation study encapsulation of adapalene in TyroSphere significantly decreased secretion of pro-inflammatory cytokines (IL-1alpha and IL-8), confirming that the TyroSphere formulation of adapalene is less irritant than the commercial gel (Differin).	Adapalene	61-70	interleukin 1 alpha	Mus musculus	150-159
30890624-0	2019	Adapalene Gel 0.1% Versus Placebo as Prophylaxis for Anti-Epidermal Growth Factor Receptor-Induced Acne-Like Rash: A Randomized Left-Right Comparative Evaluation (APPEARANCE).	Adapalene	0-9	epidermal growth factor receptor	Homo sapiens	58-90
30209580-2	2018	Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes.	Adapalene	77-82	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	0-29
30209580-2	2018	Tropomyosin-receptor kinase A (TrkA), another receptor of NGF, combined with CD271 has been involved with nervous system and skin keratinocytes.	Adapalene	77-82	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	31-35
30209580-13	2018	Our studies demonstrated that the role of TrkA in the promoting wounding-healing effect of CD271 on eSCs.	Adapalene	91-96	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	42-46
29996653-6	2018	Based on the in vitro skin irritation study encapsulation of adapalene in TyroSphere significantly decreased secretion of pro-inflammatory cytokines (IL-1alpha and IL-8), confirming that the TyroSphere formulation of adapalene is less irritant than the commercial gel (Differin).	Adapalene	61-70	chemokine (C-X-C motif) ligand 15	Mus musculus	164-168
26985947-1	2016	To explore the possible mechanism of the third-generation retinoic acid drugs (isotretinoin, acitretin, adapalene) in inducing skin and mucosa dryness and rhagades; specifically, mechanism by which these drugs influence keratinocyte cell culture models in vitro (HaCaT) and aquaporin channel (AQP3) protein expression was investigated.	Adapalene	104-113	aquaporin 3 (Gill blood group)	Homo sapiens	293-297
28805934-6	2017	Dermo-cosmetics were found to aid in restoration of fragile skin caused by the acne topical retinoid treatment adapalene 0.1% gel, by reducing transepidermal water loss and improving skin hydration, as well as reducing the side-effects such as skin irritation that are frequently associated with topical retinoids.	Adapalene	111-120	activation induced cytidine deaminase	Homo sapiens	30-33
26985947-5	2016	After treatment with isotretinoin, acitretin, or adapalene at 0.010 mg/mL for 12 h, the expression of AQP3 was the highest in the isotretinoin group, followed by the acitretin group, with the lowest expression in the adapalene group.	Adapalene	49-58	aquaporin 3 (Gill blood group)	Homo sapiens	102-106
26985947-5	2016	After treatment with isotretinoin, acitretin, or adapalene at 0.010 mg/mL for 12 h, the expression of AQP3 was the highest in the isotretinoin group, followed by the acitretin group, with the lowest expression in the adapalene group.	Adapalene	217-226	aquaporin 3 (Gill blood group)	Homo sapiens	102-106
21793939-6	2011	Association of Adapalene and BPO significantly decreased expression of Ki67, alpha(2) and alpha(6) integrins, TLR-2, beta-defensin 4 and IL-8 in inflammatory acne skin, whereas single treatments with Adapalene or BPO alone were less effective.	Adapalene	15-24	toll like receptor 2	Homo sapiens	110-115
26483036-4	2015	In vitro permeation studies of the hydrogels through HCS indicated gel containing ADP-SLN showed 2-fold more accumulation in skin layers as compared to conventional ADP gel.	Adapalene	82-85	holocarboxylase synthetase	Homo sapiens	53-56
26398439-0	2015	Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinoma.	Adapalene	0-9	cyclin dependent kinase 2	Homo sapiens	35-60
26398439-8	2015	To the best of our knowledge, the present study was the first to indicate that ADA inhibits CDK2 and is a potential candidate drug for the treatment of human colorectal cancer.	Adapalene	79-82	cyclin dependent kinase 2	Homo sapiens	92-96
25217865-11	2014	Cytokine productions including IL-10 and IL-12a tended to increase in skin treated with adapalene as compared to the control group.	Adapalene	88-97	interleukin 10	Rattus norvegicus	31-36
25217865-11	2014	Cytokine productions including IL-10 and IL-12a tended to increase in skin treated with adapalene as compared to the control group.	Adapalene	88-97	interleukin 12A	Rattus norvegicus	41-47
24805280-3	2014	METHODS: The anti-acne agent, adapalene, was encapsulated in acid-responsive polymer (Eudragit  EPO) nanocarriers via nanoprecipitation.	Adapalene	30-39	erythropoietin	Sus scrofa	96-99
26947815-2	2016	Adapalene, a third-generation topical retinoid, down-regulates toll-like receptor 2 expression and inhibits activator protein-1 activity.	Adapalene	0-9	toll like receptor 2	Homo sapiens	63-83
26947815-2	2016	Adapalene, a third-generation topical retinoid, down-regulates toll-like receptor 2 expression and inhibits activator protein-1 activity.	Adapalene	0-9	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	108-127
22728381-6	2012	Moreover, keratin 6, which stains activated keratinocytes, was strongly and uniformly induced in interfollicular epidermis of adapalene-treated mice, while only faintly and focally expressed in ST1898-treated ones.	Adapalene	126-135	keratin 6	Mus musculus	10-19
21793939-6	2011	Association of Adapalene and BPO significantly decreased expression of Ki67, alpha(2) and alpha(6) integrins, TLR-2, beta-defensin 4 and IL-8 in inflammatory acne skin, whereas single treatments with Adapalene or BPO alone were less effective.	Adapalene	15-24	defensin beta 104B	Homo sapiens	117-132
21793939-6	2011	Association of Adapalene and BPO significantly decreased expression of Ki67, alpha(2) and alpha(6) integrins, TLR-2, beta-defensin 4 and IL-8 in inflammatory acne skin, whereas single treatments with Adapalene or BPO alone were less effective.	Adapalene	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	137-141
10037194-2	1999	RAR-selective retinoids such as CD271, CD437, CD2325, and SR11364 showed potent activity in inhibiting the growth of either normal or premalignant and malignant HBE cells (IC50s mostly <1 microM) and were much more potent than RXR-selective retinoids.	Adapalene	32-37	retinoic acid receptor alpha	Homo sapiens	0-3
21864882-1	2011	6[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid (Adapalene ), a synthetic aromatic retinoid specific for RARbeta and RARgamma receptors, has been prepared utilizing a Pd/C-mediated Suzuki coupling between 6-bromo-2-naphthoic acid and 4-methoxyphenyl boronic acid, followed by introduction of an adamantyl group in the position 3 of the formed 6-(4-methoxyphenyl)-2-naphthoic acid.	Adapalene	0-51	retinoic acid receptor beta	Homo sapiens	109-116
21864882-1	2011	6[3-(1-Adamantyl)-4-methoxyphenyl]-2-naphthoic acid (Adapalene ), a synthetic aromatic retinoid specific for RARbeta and RARgamma receptors, has been prepared utilizing a Pd/C-mediated Suzuki coupling between 6-bromo-2-naphthoic acid and 4-methoxyphenyl boronic acid, followed by introduction of an adamantyl group in the position 3 of the formed 6-(4-methoxyphenyl)-2-naphthoic acid.	Adapalene	53-62	retinoic acid receptor beta	Homo sapiens	109-116
21743808-0	2011	Successful treatment of epidermal growth factor receptor inhibitor-induced periungual inflammation with adapalene.	Adapalene	104-113	epidermal growth factor receptor	Homo sapiens	24-56
21743808-3	2011	In this paper, we report 3 cases of successful treatment of periungual inflammation induced by 3 different EGFR inhibitors (gefitinib, erlotinib, and cetuximab) with topically applied adapalene.	Adapalene	184-193	epidermal growth factor receptor	Homo sapiens	107-111
21185985-5	2010	Among synthetic retinoids, isotretinoin, acitretin, tazarotene and adapalene are ligands of the RAR, bexarotene is the first rexinoid (ligand of the RXR), alitretinoin the first panagonist (RAR+ RXR).	Adapalene	67-76	retinoid X receptor alpha	Homo sapiens	195-198
17518990-0	2007	In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.	Adapalene	48-57	toll like receptor 2	Homo sapiens	23-28
17518990-0	2007	In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.	Adapalene	48-57	CD1d molecule	Homo sapiens	30-34
17518990-0	2007	In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesions.	Adapalene	48-57	interleukin 10	Homo sapiens	39-44
17518990-4	2007	The aim of our study was to investigate the new mechanisms of the anti-inflammatory activity of adapalene in vitro, and more specifically the modulatory effect of adapalene on the expression of TLR-2, CD1d, a cell surface glycoprotein that plays a role as antigen-presenting molecules and is responsible for the development of cutaneous inflammation, and also on the expression and the secretion of the anti-inflammatory interleukin (IL)-10 cytokine.	Adapalene	163-172	toll like receptor 2	Homo sapiens	194-199
17518990-4	2007	The aim of our study was to investigate the new mechanisms of the anti-inflammatory activity of adapalene in vitro, and more specifically the modulatory effect of adapalene on the expression of TLR-2, CD1d, a cell surface glycoprotein that plays a role as antigen-presenting molecules and is responsible for the development of cutaneous inflammation, and also on the expression and the secretion of the anti-inflammatory interleukin (IL)-10 cytokine.	Adapalene	163-172	CD1d molecule	Homo sapiens	201-205
17518990-4	2007	The aim of our study was to investigate the new mechanisms of the anti-inflammatory activity of adapalene in vitro, and more specifically the modulatory effect of adapalene on the expression of TLR-2, CD1d, a cell surface glycoprotein that plays a role as antigen-presenting molecules and is responsible for the development of cutaneous inflammation, and also on the expression and the secretion of the anti-inflammatory interleukin (IL)-10 cytokine.	Adapalene	163-172	interleukin 10	Homo sapiens	421-440
17518990-6	2007	On the contrary, adapalene increased CD1d expression in explants of acne patients.	Adapalene	17-26	CD1d molecule	Homo sapiens	37-41
17518990-7	2007	Thus, adapalene can modulate the epidermal immune system by increasing the CD1d expression and by decreasing the IL-10 expression by keratinocytes.	Adapalene	6-15	CD1d molecule	Homo sapiens	75-79
17518990-7	2007	Thus, adapalene can modulate the epidermal immune system by increasing the CD1d expression and by decreasing the IL-10 expression by keratinocytes.	Adapalene	6-15	interleukin 10	Homo sapiens	113-118
17518990-9	2007	The decreased expression of TLR-2 by the keratinocytes can contribute to explain the anti-inflammatory activity of adapalene observed in clinical practice.	Adapalene	115-124	toll like receptor 2	Homo sapiens	28-33
14506747-10	2003	Quantitative Western blots showed a shift of the bax:bcl-2 ratio toward proapoptotic bax in ADA-treated cells.	Adapalene	92-95	BCL2 associated X, apoptosis regulator	Homo sapiens	49-52
14506747-10	2003	Quantitative Western blots showed a shift of the bax:bcl-2 ratio toward proapoptotic bax in ADA-treated cells.	Adapalene	92-95	BCL2 apoptosis regulator	Homo sapiens	53-58
14506747-10	2003	Quantitative Western blots showed a shift of the bax:bcl-2 ratio toward proapoptotic bax in ADA-treated cells.	Adapalene	92-95	BCL2 associated X, apoptosis regulator	Homo sapiens	85-88
10651997-6	2000	Furthermore, the RAR-beta,gamma antagonist CD2665 antagonized the suppressive effects of all-trans retinoic acid, adapalene, and CD2043 on both cell growth and differentiation.	Adapalene	114-123	retinoic acid receptor, beta	Rattus norvegicus	17-25
10037194-2	1999	RAR-selective retinoids such as CD271, CD437, CD2325, and SR11364 showed potent activity in inhibiting the growth of either normal or premalignant and malignant HBE cells (IC50s mostly <1 microM) and were much more potent than RXR-selective retinoids.	Adapalene	32-37	retinoid X receptor alpha	Homo sapiens	230-233
35168402-4	2022	Adapalene demonstrated antiproliferative activity in melanoma cell lines via S-phase arrest-dependent apoptosis mediated by DNA damage through an increase in the expression of p-ATM and p-chk2 and a decrease in the expression of p-BRCA1 and Rad51.	Adapalene	0-9	ATM serine/threonine kinase	Homo sapiens	178-181
9204085-8	1997	The nuclear gene transcription factors RAR beta and RAR gamma mediate the retinoid activity of adapalene.	Adapalene	95-104	retinoic acid receptor beta	Homo sapiens	39-47
9204085-8	1997	The nuclear gene transcription factors RAR beta and RAR gamma mediate the retinoid activity of adapalene.	Adapalene	95-104	retinoic acid receptor gamma	Homo sapiens	52-61
9990413-3	1998	Furthermore, adapalene has anti-inflammatory potential as determined by its anti-AP1 activity.	Adapalene	13-22	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-84
9990413-4	1998	Adapalene interacts selectively with the nuclear receptors RAR beta and RAR gamma, and its activity on proliferation and differentiation can be blocked by a RAR beta-gamma antagonist.	Adapalene	0-9	retinoic acid receptor beta	Homo sapiens	59-67
9990413-4	1998	Adapalene interacts selectively with the nuclear receptors RAR beta and RAR gamma, and its activity on proliferation and differentiation can be blocked by a RAR beta-gamma antagonist.	Adapalene	0-9	retinoic acid receptor gamma	Homo sapiens	72-81
9990413-4	1998	Adapalene interacts selectively with the nuclear receptors RAR beta and RAR gamma, and its activity on proliferation and differentiation can be blocked by a RAR beta-gamma antagonist.	Adapalene	0-9	retinoic acid receptor beta	Homo sapiens	157-165
9990413-5	1998	Because RAR beta is not expressed in human keratinocytes, the effect of adapalene on the major cell type of the epidermis is certainly mediated by its interaction with RAR gamma.	Adapalene	72-81	retinoic acid receptor beta	Homo sapiens	8-16
9990413-5	1998	Because RAR beta is not expressed in human keratinocytes, the effect of adapalene on the major cell type of the epidermis is certainly mediated by its interaction with RAR gamma.	Adapalene	72-81	retinoic acid receptor gamma	Homo sapiens	168-177
9990415-6	1998	Adapalene 0.1% gel and adapalene 0.1% cream produced similar significant increases in CRABP-II mRNA levels compared to their vehicles (P < 0.01).	Adapalene	0-9	cellular retinoic acid binding protein 2	Homo sapiens	86-94
9990415-6	1998	Adapalene 0.1% gel and adapalene 0.1% cream produced similar significant increases in CRABP-II mRNA levels compared to their vehicles (P < 0.01).	Adapalene	23-32	cellular retinoic acid binding protein 2	Homo sapiens	86-94
9990415-9	1998	Adapalene 0.1% gel and adapalene 0.1% cream induce RAR-mediated gene expression to a similar degree in this model, without the irritant effects of tretinoin.	Adapalene	0-9	retinoic acid receptor alpha	Homo sapiens	51-54
9990415-9	1998	Adapalene 0.1% gel and adapalene 0.1% cream induce RAR-mediated gene expression to a similar degree in this model, without the irritant effects of tretinoin.	Adapalene	23-32	retinoic acid receptor alpha	Homo sapiens	51-54
9557255-3	1998	The retinoid action of adapalene are mediated by the ligand-activated gene transcription factors retinoic acid receptors RAR beta and RAR gamma.	Adapalene	23-32	retinoic acid receptor beta	Homo sapiens	121-129
9557255-3	1998	The retinoid action of adapalene are mediated by the ligand-activated gene transcription factors retinoic acid receptors RAR beta and RAR gamma.	Adapalene	23-32	retinoic acid receptor gamma	Homo sapiens	134-143
8396608-0	1993	Comparison of CD271 (adapalene) and all-trans retinoic acid in human skin: dissociation of epidermal effects and CRABP-II mRNA expression.	Adapalene	21-30	nerve growth factor receptor	Homo sapiens	14-19
8396608-1	1993	A new synthetic retinoid analogue, adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, CD271), which is relatively selective for retinoic acid receptor beta, was noted to be an effective comedolytic agent in the rhino mouse model and to have clinical efficacy against acne.	Adapalene	35-44	nerve growth factor receptor	Homo sapiens	100-105
8396608-1	1993	A new synthetic retinoid analogue, adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, CD271), which is relatively selective for retinoic acid receptor beta, was noted to be an effective comedolytic agent in the rhino mouse model and to have clinical efficacy against acne.	Adapalene	35-44	retinoic acid receptor, beta	Mus musculus	142-169
8396608-1	1993	A new synthetic retinoid analogue, adapalene (6-[3-(1-adamantyl)-4-methoxyphenyl]-2-naphthoic acid, CD271), which is relatively selective for retinoic acid receptor beta, was noted to be an effective comedolytic agent in the rhino mouse model and to have clinical efficacy against acne.	Adapalene	46-98	retinoic acid receptor, beta	Mus musculus	142-169
35608792-0	2022	Adapalene induces adipose browning through the RARbeta-p38 MAPK-ATF2 pathway.	Adapalene	0-9	activating transcription factor 2	Mus musculus	64-68
35168402-4	2022	Adapalene demonstrated antiproliferative activity in melanoma cell lines via S-phase arrest-dependent apoptosis mediated by DNA damage through an increase in the expression of p-ATM and p-chk2 and a decrease in the expression of p-BRCA1 and Rad51.	Adapalene	0-9	checkpoint kinase 2	Homo sapiens	188-192
35168402-4	2022	Adapalene demonstrated antiproliferative activity in melanoma cell lines via S-phase arrest-dependent apoptosis mediated by DNA damage through an increase in the expression of p-ATM and p-chk2 and a decrease in the expression of p-BRCA1 and Rad51.	Adapalene	0-9	BRCA1 DNA repair associated	Homo sapiens	231-236
35168402-4	2022	Adapalene demonstrated antiproliferative activity in melanoma cell lines via S-phase arrest-dependent apoptosis mediated by DNA damage through an increase in the expression of p-ATM and p-chk2 and a decrease in the expression of p-BRCA1 and Rad51.	Adapalene	0-9	RAD51 recombinase	Homo sapiens	241-246
32438389-0	2020	Application of ultrasound-mediated adapalene-coated lysozyme-shelled microbubbles in UVA-induced skin photoaging.	Adapalene	35-44	lysozyme	Homo sapiens	52-60
32292776-3	2020	Our approach utilized the RARbeta agonist adapalene, which we previously found to be neuroprotective in vitro.	Adapalene	42-51	retinoic acid receptor, alpha	Mus musculus	26-33
32292776-5	2020	To address this challenge, we encapsulated adapalene within nanoparticles (Adap-NPs) composed of poly(lactic acid)-poly(ethylene glycol) (PLA-PEG).	Adapalene	43-52	amyloid beta (A4) precursor protein	Mus musculus	75-79