PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 20971925-6 2010 Conversely, treatment with Cox-derived prostanoids PGD(2) or 15-deoxy-Delta(12,14)-PGJ(2) induced hBD3 or hBD2 and hBD3, respectively. 15-deoxy-delta 61-75 defensin beta 103B Homo sapiens 98-102 20971925-6 2010 Conversely, treatment with Cox-derived prostanoids PGD(2) or 15-deoxy-Delta(12,14)-PGJ(2) induced hBD3 or hBD2 and hBD3, respectively. 15-deoxy-delta 61-75 defensin beta 4A Homo sapiens 106-110 20971925-6 2010 Conversely, treatment with Cox-derived prostanoids PGD(2) or 15-deoxy-Delta(12,14)-PGJ(2) induced hBD3 or hBD2 and hBD3, respectively. 15-deoxy-delta 61-75 defensin beta 103B Homo sapiens 115-119 20670683-3 2010 For comparison, pravastatin, isosorbide-5-mononitrate (ISMN), sodium nitroprusside (SNP) and the PPARgamma ligand 15-deoxy-Delta(12,14)-prostaglandin J(2) (PGJ) were also tested. 15-deoxy-delta 114-128 peroxisome proliferator activated receptor gamma Homo sapiens 97-106 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 peroxisome proliferator activated receptor gamma Homo sapiens 24-33 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 insulin like growth factor 1 receptor Homo sapiens 109-115 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 peroxisome proliferator activated receptor gamma Homo sapiens 190-199 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 insulin like growth factor 1 receptor Homo sapiens 237-243 20843793-4 2010 However, the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2), dose dependently reduced IGF-1R (10 mumol/liter, 80% decrease, n = 4, p < 0.01), and overexpression of PPARgamma using an adenovirus likewise reduced IGF-1R (50% decrease versus SMC infected with control adenovirus), suggesting a PPARgamma-independent action of TZDs. 15-deoxy-delta 42-56 peroxisome proliferator activated receptor gamma Homo sapiens 190-199 19448671-1 2009 Thiol reactive cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ2), induced a novel, nonapoptotic and microtubule-associated protein 1 light chain 3 (MAP1 LC3) dependent but nonautophagic form of cell death in colon, breast and prostate cancer cell lines, characterized by extensive cytoplasmic vacuolation with dilatation of endoplasmic reticulum (ER). 15-deoxy-delta 45-59 microtubule associated protein 1 light chain 3 alpha Homo sapiens 185-188 19739114-5 2010 Three different methods of inhibiting mPGES-1 (RNA interference, a novel small molecule inhibitor and the endogenous inhibitor 15-deoxy-Delta(12,14)-PGJ(2)) also blocked leptin induced mPGES-1 expression and PGE2 production and abolished the leptin-induced proliferative and anti-apoptotic effects in OE33 cells, without affecting COX-2 expression. 15-deoxy-delta 127-141 prostaglandin E synthase Mus musculus 38-45 19739114-5 2010 Three different methods of inhibiting mPGES-1 (RNA interference, a novel small molecule inhibitor and the endogenous inhibitor 15-deoxy-Delta(12,14)-PGJ(2)) also blocked leptin induced mPGES-1 expression and PGE2 production and abolished the leptin-induced proliferative and anti-apoptotic effects in OE33 cells, without affecting COX-2 expression. 15-deoxy-delta 127-141 prostaglandin E synthase Mus musculus 185-192 20036328-11 2010 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta 212-226 aldo-keto reductase family 1 member C3 Homo sapiens 14-20 20036328-11 2010 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta 212-226 aldo-keto reductase family 1 member C3 Homo sapiens 102-108 20036328-11 2010 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta 212-226 peroxisome proliferator activated receptor gamma Homo sapiens 116-164 20036328-11 2010 Expression of AKR1C3 reduced the anti-proliferative effects of PGD(2) on MCF-7 cells, suggesting that AKR1C3 limits peroxisome proliferator activated receptor gamma (PPARgamma) signaling by reducing formation of 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)). 15-deoxy-delta 212-226 peroxisome proliferator activated receptor gamma Homo sapiens 166-175 20438519-1 2010 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an endogenous peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that suppresses progressive matrix deposition; however, little is known about the effects of 15d-PGJ(2) on human peritoneal mesothelial cells (HPMCs). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 71-119 20438519-1 2010 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is an endogenous peroxisome proliferator-activated receptor gamma (PPARgamma) agonist that suppresses progressive matrix deposition; however, little is known about the effects of 15d-PGJ(2) on human peritoneal mesothelial cells (HPMCs). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 121-130 19286977-5 2009 The inhibitory concentration causing a 50% decrease in aSMA for CDDO was 20-fold lower than the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15 d-PGJ(2)), and 400-fold lower than the synthetic ligand, rosiglitazone. 15-deoxy-delta 125-139 peroxisome proliferator activated receptor gamma Homo sapiens 107-116 19723057-3 2009 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a representative cyPG of the J series, has been reported to directly inhibit the activity of redox-sensitive transcription factors, such as activator protein-1 and nuclear factor-kappaB. 15-deoxy-delta 0-14 JunD proto-oncogene, AP-1 transcription factor subunit Homo sapiens 195-214 19275963-1 2009 A series of analogues of the PPARgamma ligand 15-deoxy-Delta(12,14)-PGJ(2) have been synthesized by functionalization of a 5-alkyl-4-hydroxycyclopentenone core structure obtained by Piancatelli rearrangement of precursor furylcarbinol. 15-deoxy-delta 46-60 peroxisome proliferator activated receptor gamma Homo sapiens 29-38 19346435-5 2009 We found that synthetic PPARgamma agonists, rosiglitazone (RGZ) and troglitazone (TGZ), induced proliferation of human bronchial epithelial cells, whereas the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), inhibited cell growth. 15-deoxy-delta 188-202 peroxisome proliferator activated receptor gamma Homo sapiens 24-33 19346435-5 2009 We found that synthetic PPARgamma agonists, rosiglitazone (RGZ) and troglitazone (TGZ), induced proliferation of human bronchial epithelial cells, whereas the endogenous PPARgamma ligand, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), inhibited cell growth. 15-deoxy-delta 188-202 peroxisome proliferator activated receptor gamma Homo sapiens 170-179 19673929-9 2009 Three different TZDs (ciglitazone, rosiglitazone and troglitazone) and the endogenous PPARgamma ligand 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) inhibited CMF proliferation (cell number and expression of proliferating cell nuclear antigen) in a concentration-dependent manner (range 0.1-10 micromol/L) with similar potencies. 15-deoxy-delta 103-117 peroxisome proliferator activated receptor gamma Homo sapiens 86-95 19018984-3 2009 Recently, we demonstrated that the methylxanthine derivate caffeine leads to an upregulation of peroxisome proliferator activated receptor gamma (PPARgamma) expression in hepatocytes, thus sensitizing these cells to the well-known inhibitory effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on CTGF expression. 15-deoxy-delta 252-266 peroxisome proliferator activated receptor gamma Homo sapiens 96-144 19018984-3 2009 Recently, we demonstrated that the methylxanthine derivate caffeine leads to an upregulation of peroxisome proliferator activated receptor gamma (PPARgamma) expression in hepatocytes, thus sensitizing these cells to the well-known inhibitory effect of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15-d-PGJ(2)) on CTGF expression. 15-deoxy-delta 252-266 peroxisome proliferator activated receptor gamma Homo sapiens 146-155 19416639-6 2009 The transfectants with COX-2 were sensitive to exogenous 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone as peroxisome proliferator-activated receptor gamma (PPARgamma) agonists during the maturation phase for restoring the adipogenesis. 15-deoxy-delta 57-71 mitochondrially encoded cytochrome c oxidase II Homo sapiens 23-28 18208815-8 2008 On the other hand, Ox-LDL increased intracellular 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) level through ERK1/2-dependent overexpression of COX-2. 15-deoxy-delta 50-64 mitogen-activated protein kinase 3 Mus musculus 118-124 18983509-2 2009 Recently, we demonstrated that the natural peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), augments platelet numbers by increasing platelet release from megakaryocytes through the induction of reactive oxygen species (ROS). 15-deoxy-delta 112-126 peroxisome proliferator activated receptor gamma Homo sapiens 43-91 18983509-2 2009 Recently, we demonstrated that the natural peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), augments platelet numbers by increasing platelet release from megakaryocytes through the induction of reactive oxygen species (ROS). 15-deoxy-delta 112-126 peroxisome proliferator activated receptor gamma Homo sapiens 93-102 18535203-6 2008 PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct. 15-deoxy-delta 172-186 tubulin-specific chaperone E Mus musculus 0-3 18535203-6 2008 PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct. 15-deoxy-delta 172-186 C-X-C motif chemokine ligand 8 Homo sapiens 77-81 18535203-6 2008 PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct. 15-deoxy-delta 172-186 peroxisome proliferator activated receptor gamma Homo sapiens 136-146 18535203-6 2008 PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct. 15-deoxy-delta 172-186 tubulin-specific chaperone E Mus musculus 249-252 18535203-6 2008 PMN chemotactic responses to formylmethionyl-leucyl-phenylalanine (fMLP) and IL-8 were dose-dependently inhibited by treatment with the PPAR-gamma ligands troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and by transfection of PMN-like HL-60 cells with a constitutively active PPAR-gamma construct. 15-deoxy-delta 172-186 peroxisome proliferator activated receptor gamma Homo sapiens 299-309 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 96-145 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 147-156 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 retinoid X receptor alpha Homo sapiens 159-178 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 retinoid X receptor alpha Homo sapiens 180-188 19101554-1 2009 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) activates a nuclear receptor heterodimer, peroxisome proliferators-activated receptor gamma (PPARgamma)/ retinoid X receptor (RXRalpha) through covalent binding to Cys285 in PPARgamma ligand-binding domain (LBD). 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 228-237 18755987-4 2008 Herein, we report that an important lipid mediator and a peroxisome proliferator-activated receptor gamma (PPARgamma) ligand called 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), increases Meg-01 maturation and platelet production. 15-deoxy-delta 132-146 peroxisome proliferator activated receptor gamma Mus musculus 57-105 18755987-4 2008 Herein, we report that an important lipid mediator and a peroxisome proliferator-activated receptor gamma (PPARgamma) ligand called 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), increases Meg-01 maturation and platelet production. 15-deoxy-delta 132-146 peroxisome proliferator activated receptor gamma Mus musculus 107-116 18463970-0 2008 15-deoxy-Delta(12,14)-prostaglandin J(2) and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. 15-deoxy-delta 0-14 toll-like receptor 4 Mus musculus 81-108 18208815-8 2008 On the other hand, Ox-LDL increased intracellular 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) level through ERK1/2-dependent overexpression of COX-2. 15-deoxy-delta 50-64 prostaglandin-endoperoxide synthase 2 Mus musculus 153-158 18231633-1 2008 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and an anti-diabetic thiazolidinedione, troglitazone (TRO) are peroxisome proliferator-activated receptor (PPAR)-gamma ligands, which regulate immuno-inflammatory reactions as well as adipocyte differentiation. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Mus musculus 117-172 18535368-3 2008 This study examined the ability of statins and TZDs and the natural peroxisome proliferator activated receptor-gamma (PPARgamma) agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) (PGJ(2)) to attenuate the proteinuria-induced pro-inflammatory phenotype of PTEC. 15-deoxy-delta 137-151 peroxisome proliferator activated receptor gamma Mus musculus 68-116 18535368-3 2008 This study examined the ability of statins and TZDs and the natural peroxisome proliferator activated receptor-gamma (PPARgamma) agonist 15-deoxy-Delta(12,14)-prostaglandin J(2) (PGJ(2)) to attenuate the proteinuria-induced pro-inflammatory phenotype of PTEC. 15-deoxy-delta 137-151 peroxisome proliferator activated receptor gamma Mus musculus 118-127 18278065-5 2008 KEY RESULTS: In growth-arrested cardiac fibroblasts, PPAR-gamma ligands rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) dose-dependently attenuated Ang II-induced cell proliferation and expression of PAI-1, collagen type-I, collagen type-III and fibronectin. 15-deoxy-delta 90-104 peroxisome proliferator-activated receptor gamma Rattus norvegicus 53-63 18278065-5 2008 KEY RESULTS: In growth-arrested cardiac fibroblasts, PPAR-gamma ligands rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) dose-dependently attenuated Ang II-induced cell proliferation and expression of PAI-1, collagen type-I, collagen type-III and fibronectin. 15-deoxy-delta 90-104 angiotensinogen Rattus norvegicus 168-174 18278065-5 2008 KEY RESULTS: In growth-arrested cardiac fibroblasts, PPAR-gamma ligands rosiglitazone and 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) dose-dependently attenuated Ang II-induced cell proliferation and expression of PAI-1, collagen type-I, collagen type-III and fibronectin. 15-deoxy-delta 90-104 serpin family E member 1 Rattus norvegicus 220-277 16386710-5 2006 In U937 cells niacin-induced expression of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), the most potent endogenous ligand of PPARgamma. 15-deoxy-delta 43-57 peroxisome proliferator activated receptor gamma Homo sapiens 135-144 17405918-7 2007 Under our conditions, biotinylated 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)-B) was more efficient than biotinylated PGA(1) (PGA(1)-B) at forming adducts with components of the transcription factors NF-kappaB and activator protein-1 (AP-1). 15-deoxy-delta 35-49 autoimmune regulator Homo sapiens 124-132 17405918-7 2007 Under our conditions, biotinylated 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)-B) was more efficient than biotinylated PGA(1) (PGA(1)-B) at forming adducts with components of the transcription factors NF-kappaB and activator protein-1 (AP-1). 15-deoxy-delta 35-49 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 212-231 17405918-7 2007 Under our conditions, biotinylated 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)-B) was more efficient than biotinylated PGA(1) (PGA(1)-B) at forming adducts with components of the transcription factors NF-kappaB and activator protein-1 (AP-1). 15-deoxy-delta 35-49 JunB proto-oncogene, AP-1 transcription factor subunit Homo sapiens 233-237 16844232-4 2006 In this study, we show that the PPARgamma antagonists, Bisphenol A diglycidyl ether (BADGE) and 2-chloro-5-nitro-N-(4-pyridyl)benzamide (T0070907), reverse the inhibition of EAE by the PPARgamma agonists, Ciglitazone and 15-Deoxy-Delta(12,14)-Prostaglandin J2, in C57BL/6 wild-type and PPARgamma+/- mice. 15-deoxy-delta 221-235 peroxisome proliferator activated receptor gamma Mus musculus 32-41 16824197-4 2006 We found that ATM is activated by N-methyl-N"-nitro-nitrosoguanidine (MNNG) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), in NBS1- or MSH6-deficient cells. 15-deoxy-delta 80-94 ATM serine/threonine kinase Homo sapiens 14-17 16601291-6 2006 A PPARgamma activator, 15-deoxy-Delta(12,14)- prostaglandin J(2) (15d-PGJ(2)), significantly inhibited estrogen-responsive element-dependent transactivation by estradiol in MCF-7 cells, which was blocked by addition of a PPARgamma antagonist GW9662. 15-deoxy-delta 23-37 peroxisome proliferator activated receptor gamma Homo sapiens 2-11 16601291-6 2006 A PPARgamma activator, 15-deoxy-Delta(12,14)- prostaglandin J(2) (15d-PGJ(2)), significantly inhibited estrogen-responsive element-dependent transactivation by estradiol in MCF-7 cells, which was blocked by addition of a PPARgamma antagonist GW9662. 15-deoxy-delta 23-37 peroxisome proliferator activated receptor gamma Homo sapiens 221-230 18615183-8 2008 In the present study, Abeta(1-42) synergistically elevated the expression of IL-12 and IL-23 triggered by inflammatory activation of microglia, and the peroxisome proliferator-activated receptor (PPAR)-gamma agonist 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) effectively blocked the elevation of these proinflammatory cytokines. 15-deoxy-delta 216-230 peroxisome proliferator activated receptor gamma Homo sapiens 152-207 18162716-0 2007 ERK-1/-2 and p38 kinase oppositely regulate 15-deoxy-delta(12,14)-prostaglandinJ(2)-Induced PPAR-gamma activation that mediates dedifferentiation but not cyclooxygenase-2 expression in articular chondrocytes. 15-deoxy-delta 44-58 peroxisome proliferator-activated receptor gamma Oryctolagus cuniculus 92-102 17706193-0 2007 Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. 15-deoxy-delta 197-211 estrogen receptor 2 Homo sapiens 14-36 17706193-0 2007 Inhibition of estrogen receptor beta-mediated human telomerase reverse transcriptase gene transcription via the suppression of mitogen-activated protein kinase signaling plays an important role in 15-deoxy-Delta(12,14)-prostaglandin J(2)-induced apoptosis in cancer cells. 15-deoxy-delta 197-211 telomerase reverse transcriptase Homo sapiens 52-84 17707368-0 2007 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. 15-deoxy-delta 0-14 C-X-C motif chemokine receptor 4 Homo sapiens 56-61 17707368-0 2007 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 89-99 17707368-0 2007 15-Deoxy-delta(12,14)-prostaglandin J(2) down-regulates CXCR4 on carcinoma cells through PPARgamma- and NFkappaB-mediated pathways. 15-deoxy-delta 0-14 nuclear factor kappa B subunit 1 Homo sapiens 104-112 17592505-5 2007 KEY RESULTS: Peroxisome proliferator-activated receptor gamma activators inhibited the metabolism of the endocannabinoid anandamide in rat brain homogenates with an order of potency MCC-555 > indomethacin approximately ciglitazone approximately 15-deoxy-Delta(12,14)-prostaglandin J(2) approximately pioglitazone > rosiglitazone > troglitazone. 15-deoxy-delta 248-262 peroxisome proliferator-activated receptor gamma Rattus norvegicus 13-61 16484546-5 2006 Recently, we examined the role of PPARgamma in EAE and observed that administration of the PPARgamma agonist 15-deoxy-Delta(12,14) prostaglandin J2 exerted a significant therapeutic effect predominantly by inhibiting the activation and expansion of encephalitogenic T cells. 15-deoxy-delta 109-123 peroxisome proliferator activated receptor gamma Homo sapiens 34-43 16484546-5 2006 Recently, we examined the role of PPARgamma in EAE and observed that administration of the PPARgamma agonist 15-deoxy-Delta(12,14) prostaglandin J2 exerted a significant therapeutic effect predominantly by inhibiting the activation and expansion of encephalitogenic T cells. 15-deoxy-delta 109-123 peroxisome proliferator activated receptor gamma Homo sapiens 91-100 16310861-6 2006 Additional to DP receptors, the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) binds the nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and has the facility to initiate a variety of anti-inflammatory phenotypes either through or independent of PPARgamma association. 15-deoxy-delta 50-64 hematopoietic prostaglandin D synthase Homo sapiens 32-38 16310861-6 2006 Additional to DP receptors, the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) binds the nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and has the facility to initiate a variety of anti-inflammatory phenotypes either through or independent of PPARgamma association. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 110-158 16310861-6 2006 Additional to DP receptors, the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) binds the nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and has the facility to initiate a variety of anti-inflammatory phenotypes either through or independent of PPARgamma association. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 160-169 16310861-6 2006 Additional to DP receptors, the PGD(2) metabolite 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) binds the nuclear peroxisome proliferator-activated receptor gamma (PPARgamma) and has the facility to initiate a variety of anti-inflammatory phenotypes either through or independent of PPARgamma association. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 279-288 16253239-5 2005 15-Deoxy-Delta(12,14) prostaglandin J2 is, an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), has been known to possess proapoptotic potential in diverse cell types. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 68-116 16020752-1 2005 OBJECTIVE: We recently reported that the peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and ciglitazone increased cultured endothelial cell nitric oxide (NO) release without increasing the expression of endothelial nitric oxide synthase (eNOS). 15-deoxy-delta 110-124 peroxisome proliferator activated receptor gamma Homo sapiens 41-89 16253239-5 2005 15-Deoxy-Delta(12,14) prostaglandin J2 is, an endogenous ligand for peroxisome proliferator-activated receptor gamma (PPARgamma), has been known to possess proapoptotic potential in diverse cell types. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 118-127 16077033-1 2005 15-Deoxy-Delta(12,14) prostaglandin J2 (15d-PGJ2) is a natural ligand for the peroxisome proliferator-activated receptor gamma (PPARgamma) that exhibits antiproliferative activity in colon cancer cells, but its mechanism of action is still poorly understood. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 78-126 16077033-1 2005 15-Deoxy-Delta(12,14) prostaglandin J2 (15d-PGJ2) is a natural ligand for the peroxisome proliferator-activated receptor gamma (PPARgamma) that exhibits antiproliferative activity in colon cancer cells, but its mechanism of action is still poorly understood. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 128-137 16020752-1 2005 OBJECTIVE: We recently reported that the peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and ciglitazone increased cultured endothelial cell nitric oxide (NO) release without increasing the expression of endothelial nitric oxide synthase (eNOS). 15-deoxy-delta 110-124 peroxisome proliferator activated receptor gamma Homo sapiens 91-100 16020752-1 2005 OBJECTIVE: We recently reported that the peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and ciglitazone increased cultured endothelial cell nitric oxide (NO) release without increasing the expression of endothelial nitric oxide synthase (eNOS). 15-deoxy-delta 110-124 nitric oxide synthase 3 Homo sapiens 275-308 15843042-8 2005 The PGJ(2) metabolites, 15-deoxy-Delta(12,14)-PGJ(2) and Delta(12)-PGJ(2), exhibited effective apoptosis-inducing activity in HL-60 cells through ROS production via activation of the caspase 3 cascade. 15-deoxy-delta 24-38 caspase 3 Homo sapiens 183-192 16024620-5 2005 Enzymatic products of stromal cell L-PGDS included high levels of PGD2 and 15-deoxy-delta(12,14)-PGD2 but low levels of 15-deoxy-delta(12,14)-prostaglandin J2. 15-deoxy-delta 75-89 prostaglandin D2 synthase Homo sapiens 35-41 16024620-5 2005 Enzymatic products of stromal cell L-PGDS included high levels of PGD2 and 15-deoxy-delta(12,14)-PGD2 but low levels of 15-deoxy-delta(12,14)-prostaglandin J2. 15-deoxy-delta 120-134 prostaglandin D2 synthase Homo sapiens 35-41 15713689-7 2005 A further metabolite of PGJ(2), 15-deoxy-Delta(12,14)-PGJ(2), a peroxisome proliferator-activated receptor-gamma agonist, led paradoxically to a small increase in NGF mRNA level but a fall in NGF secretion. 15-deoxy-delta 32-46 peroxisome proliferator activated receptor gamma Mus musculus 64-112 15713689-7 2005 A further metabolite of PGJ(2), 15-deoxy-Delta(12,14)-PGJ(2), a peroxisome proliferator-activated receptor-gamma agonist, led paradoxically to a small increase in NGF mRNA level but a fall in NGF secretion. 15-deoxy-delta 32-46 nerve growth factor Mus musculus 163-166 15713689-7 2005 A further metabolite of PGJ(2), 15-deoxy-Delta(12,14)-PGJ(2), a peroxisome proliferator-activated receptor-gamma agonist, led paradoxically to a small increase in NGF mRNA level but a fall in NGF secretion. 15-deoxy-delta 32-46 nerve growth factor Mus musculus 192-195 16000871-1 2005 15-deoxy-delta(12,14)-PGJ(2)(15d-PGJ(2)) is a natural ligand that activates the peroxisome proliferators-activated receptor (PPAR) gamma, a member of nuclear receptor family implicated in regulation of lipid metabolism and adipocyte differentiation. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 80-136 15778364-6 2005 CD40 engagement with CD40L significantly blunted the ability of PPARgamma agonists to induce apoptosis of B lymphocytes and prevented the inhibition of NF-kappaB mobilization by 15-deoxy-Delta(12,14)-PGJ(2) and ciglitazone. 15-deoxy-delta 178-192 CD40 antigen Mus musculus 0-4 15778364-6 2005 CD40 engagement with CD40L significantly blunted the ability of PPARgamma agonists to induce apoptosis of B lymphocytes and prevented the inhibition of NF-kappaB mobilization by 15-deoxy-Delta(12,14)-PGJ(2) and ciglitazone. 15-deoxy-delta 178-192 CD40 ligand Mus musculus 21-26 15778364-6 2005 CD40 engagement with CD40L significantly blunted the ability of PPARgamma agonists to induce apoptosis of B lymphocytes and prevented the inhibition of NF-kappaB mobilization by 15-deoxy-Delta(12,14)-PGJ(2) and ciglitazone. 15-deoxy-delta 178-192 peroxisome proliferator activated receptor gamma Mus musculus 64-73 15778364-6 2005 CD40 engagement with CD40L significantly blunted the ability of PPARgamma agonists to induce apoptosis of B lymphocytes and prevented the inhibition of NF-kappaB mobilization by 15-deoxy-Delta(12,14)-PGJ(2) and ciglitazone. 15-deoxy-delta 178-192 nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105 Mus musculus 152-161 15819389-1 2005 15-Deoxy-delta(12, 14)-prostaglandin J2 (15d-PG J2) is a regulator of a nuclear transcriptional factor, peroxisome proliferator-activated receptor (PPAR)-gamma. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Mus musculus 104-159 15748950-1 2005 Peroxisome proliferator-activated receptor (PPAR)-gamma agonists, including thiazolidinediones (TZDs) and 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)), have been shown to be effective in the treatment of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS). 15-deoxy-delta 106-120 peroxisome proliferator activated receptor gamma Mus musculus 0-55 15822171-4 2005 Among their substrates, GSTs conjugate the signaling molecules 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal with glutathione, and consequently they antagonize expression of genes trans-activated by the peroxisome proliferator-activated receptor gamma (PPARgamma) and nuclear factor-erythroid 2 p45-related factor 2 (Nrf2). 15-deoxy-delta 63-77 glutathione S-transferase, alpha 4 Mus musculus 24-28 15822171-4 2005 Among their substrates, GSTs conjugate the signaling molecules 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2) and 4-hydroxynonenal with glutathione, and consequently they antagonize expression of genes trans-activated by the peroxisome proliferator-activated receptor gamma (PPARgamma) and nuclear factor-erythroid 2 p45-related factor 2 (Nrf2). 15-deoxy-delta 63-77 NFE2 like bZIP transcription factor 2 Homo sapiens 342-346 15531761-4 2005 We reported here that the PPARgamma agonists 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) and troglitazone, but not PPARalpha agonist WY-14643, inhibited TNFalpha-induced production of eotaxin and monocyte chemotactic protein-1 (MCP-1) but not IL-8. 15-deoxy-delta 45-59 peroxisome proliferator activated receptor gamma Homo sapiens 26-35 14693716-7 2004 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, also inhibited TGF-beta1-induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Mus musculus 65-75 15994020-7 2005 The natural peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-delta(12,14) prostaglandin J2, and the cyclic AMP analog, bromo cyclic AMP, significantly attenuated the strong induction of peroxisome proliferator-activated receptor-gamma and inducible nitric oxide synthase, while they partially reversed the inhibitory effect of OTA on glial fibrillary acidic protein. 15-deoxy-delta 69-83 peroxisome proliferator-activated receptor gamma Rattus norvegicus 12-60 15994020-7 2005 The natural peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-delta(12,14) prostaglandin J2, and the cyclic AMP analog, bromo cyclic AMP, significantly attenuated the strong induction of peroxisome proliferator-activated receptor-gamma and inducible nitric oxide synthase, while they partially reversed the inhibitory effect of OTA on glial fibrillary acidic protein. 15-deoxy-delta 69-83 peroxisome proliferator-activated receptor gamma Rattus norvegicus 203-251 15994020-7 2005 The natural peroxisome proliferator-activated receptor-gamma ligand, 15-deoxy-delta(12,14) prostaglandin J2, and the cyclic AMP analog, bromo cyclic AMP, significantly attenuated the strong induction of peroxisome proliferator-activated receptor-gamma and inducible nitric oxide synthase, while they partially reversed the inhibitory effect of OTA on glial fibrillary acidic protein. 15-deoxy-delta 69-83 nitric oxide synthase 2 Rattus norvegicus 256-287 15289320-2 2004 Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)). 15-deoxy-delta 121-135 vascular endothelial growth factor A Homo sapiens 54-58 15289320-2 2004 Here we show that phorbol ester-mediated induction of VEGF and COX-2 expression in colon carcinoma cells is inhibited by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)). 15-deoxy-delta 121-135 mitochondrially encoded cytochrome c oxidase II Homo sapiens 63-68 15265671-0 2004 15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. 15-deoxy-delta 0-14 interleukin 1 alpha Homo sapiens 47-51 15265671-0 2004 15-deoxy-delta (12,14)-PGJ2 inhibits astrocyte IL-1 signaling: inhibition of NF-kappaB and MAP kinase pathways and suppression of cytokine and chemokine expression. 15-deoxy-delta 0-14 nuclear factor kappa B subunit 1 Homo sapiens 77-86 15023995-4 2004 PPARgamma ligands 15-deoxy-Delta(12,14) prostaglandin J(2) (15d-PGJ(2)) and the thiazolidinedione troglitazone (TRO), but not PPARalpha ligand Wy14643, dose-dependently suppressed IL-1beta-induced PGE(2) production, as well as mPGES-1 protein and mRNA expression. 15-deoxy-delta 18-32 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 14998722-2 2004 Herein we examined how various eicosanoids affect the induction of HO-1, and the possible mechanism underlying 15-deoxy-Delta(12,14)- prostaglandin J(2) (15d-PGJ(2))-induced HO-1 expression. 15-deoxy-delta 111-125 heme oxygenase 1 Homo sapiens 174-178 14715242-2 2004 In normoxia VEGF synthesis is upregulated by 15-deoxy-Delta(12,14)-prostaglandin-J(2) (15d-PGJ(2)) via induction of heme oxygenase-1 (HO-1). 15-deoxy-delta 45-59 vascular endothelial growth factor A Homo sapiens 12-16 14693716-7 2004 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, also inhibited TGF-beta1-induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1. 15-deoxy-delta 0-14 transforming growth factor, beta 1 Mus musculus 99-108 14693716-7 2004 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, also inhibited TGF-beta1-induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1. 15-deoxy-delta 0-14 fibronectin 1 Mus musculus 117-128 14693716-7 2004 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, also inhibited TGF-beta1-induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1. 15-deoxy-delta 0-14 jun proto-oncogene Mus musculus 155-159 14693716-7 2004 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), a natural PPAR-gamma ligand, also inhibited TGF-beta1-induced fibronectin expression by suppressing AP-1 activation by TGF-beta 1. 15-deoxy-delta 0-14 transforming growth factor, beta 1 Mus musculus 174-184 14673141-0 2004 Transcription factor Nrf2 regulates inflammation by mediating the effect of 15-deoxy-Delta(12,14)-prostaglandin j(2). 15-deoxy-delta 76-90 nuclear factor, erythroid derived 2, like 2 Mus musculus 21-25 14555212-3 2003 Recently, it has been shown that activation of PPARgamma by J(2) series cyclopentenone prostaglandins (cyPGs), especially 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) or synthetic agents, such as antidiabetic thiazolidinediones, causes anti-proliferation, apoptosis, differentiation, and anti-inflammation of certain types of cancer cells. 15-deoxy-delta 122-136 peroxisome proliferator activated receptor gamma Homo sapiens 47-56 14607914-1 2003 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) is a naturally occurring cyclopentenone metabolite of PGD(2) that possesses both peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent and PPAR-gamma-independent anti-inflammatory properties. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 123-171 14607914-1 2003 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) is a naturally occurring cyclopentenone metabolite of PGD(2) that possesses both peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent and PPAR-gamma-independent anti-inflammatory properties. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 173-183 14607914-1 2003 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)) is a naturally occurring cyclopentenone metabolite of PGD(2) that possesses both peroxisome proliferator-activated receptor gamma (PPAR-gamma)-dependent and PPAR-gamma-independent anti-inflammatory properties. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 199-209 14580366-4 2003 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a natural ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and affects the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 78-126 14580366-4 2003 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a natural ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma) and affects the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 128-138 14507638-7 2003 Interestingly, only Thy-1(-), but not Thy-1(+) subsets differentiated to lipofibroblasts, as determined by the accumulation of cytoplasmic lipid droplets after treatment with 15-deoxy-Delta(12, 14)-PGJ(2) or ciglitazone. 15-deoxy-delta 175-189 Thy-1 cell surface antigen Homo sapiens 20-25 12454768-3 2002 In this study, treatment with 15-deoxy-Delta(12,14)-PGJ(2) (15-PGJ(2)), a natural PPARgamma ligand, induced a significant reduction of oral squamous cell carcinoma cell growth, which was mainly attributed to upregulation of apoptosis. 15-deoxy-delta 30-44 peroxisome proliferator activated receptor gamma Homo sapiens 82-91 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. 15-deoxy-delta 167-181 interferon gamma Homo sapiens 22-31 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. 15-deoxy-delta 167-181 nitric oxide synthase 2 Homo sapiens 63-67 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. 15-deoxy-delta 167-181 nitric oxide synthase 2 Homo sapiens 89-93 12847270-3 2003 The results show that IFN-gamma-induced inducible NO synthase (iNOS) gene transcription, iNOS protein induction, and NO production are more sensitive to inhibition by 15-deoxy-Delta(12,14)-prostaglandin J(2) (15dPGJ(2)) than by the other two PPARgamma agonists, GW1929 and ciglitazone. 15-deoxy-delta 167-181 peroxisome proliferator activated receptor gamma Homo sapiens 242-251 12704651-1 2003 15-deoxy-Delta(12,14) prostaglandin J(2) (15dPGJ(2)), a peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, induced synergistic stimulation of DNA synthesis in the presence of phorbol dibutyrate (PDB) in Swiss 3T3 cells. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Mus musculus 56-104 12704651-1 2003 15-deoxy-Delta(12,14) prostaglandin J(2) (15dPGJ(2)), a peroxisome proliferator-activated receptor gamma (PPARgamma) ligand, induced synergistic stimulation of DNA synthesis in the presence of phorbol dibutyrate (PDB) in Swiss 3T3 cells. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Mus musculus 106-115 12731885-0 2003 Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. 15-deoxy-delta 131-145 ATP binding cassette subfamily C member 1 Homo sapiens 0-36 12731885-0 2003 Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells. 15-deoxy-delta 131-145 ATP binding cassette subfamily C member 3 Homo sapiens 41-45 12615709-1 2003 Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) alpha proteins, and this was accompanied by decreased cell proliferation and G(1)-G(0)-->S-phase progression. 15-deoxy-delta 114-128 peroxisome proliferator activated receptor alpha Homo sapiens 34-76 12615709-1 2003 Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) alpha proteins, and this was accompanied by decreased cell proliferation and G(1)-G(0)-->S-phase progression. 15-deoxy-delta 114-128 peroxisome proliferator activated receptor alpha Homo sapiens 78-82 12615709-1 2003 Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) alpha proteins, and this was accompanied by decreased cell proliferation and G(1)-G(0)-->S-phase progression. 15-deoxy-delta 114-128 cyclin D1 Homo sapiens 212-221 12615709-1 2003 Treatment of MCF-7 cells with the peroxisome proliferator-activated receptor (PPAR) gamma agonists ciglitazone or 15-deoxy-Delta 12,14-prostaglandin J2 resulted in a concentration- and time-dependent decrease of cyclin D1 and estrogen receptor (ER) alpha proteins, and this was accompanied by decreased cell proliferation and G(1)-G(0)-->S-phase progression. 15-deoxy-delta 114-128 estrogen receptor 1 Homo sapiens 226-254 12759491-2 2003 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and known to modulate the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 70-118 12759491-2 2003 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) is a ligand for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), and known to modulate the expression of various genes. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 120-130 12604364-2 2003 Using real-time RT-PCR the present study investigates the impact of two PPAR-gamma agonists, 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) and ciglitazone, on the expression of several proinflammatory genes in lipopolysaccharide (LPS)-stimulated human blood monocytes. 15-deoxy-delta 93-107 peroxisome proliferator activated receptor gamma Homo sapiens 72-82 14515149-2 2003 The most potent endogenous PPARgamma activator is 15-deoxy-Delta(12,14)prostaglandin-J(2) (15d-PGJ(2)), whereas synthetic ligands include the oral antidiabetic drugs thiazolidinediones (TZDs). 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 27-36 12524224-3 2003 METHODS AND RESULTS: The PPARgamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) or ciglitazone, stimulated a PPAR response element-luciferase reporter construct in transfected porcine pulmonary artery endothelial cells (PAECs), demonstrating that PPARgamma was transcriptionally functional. 15-deoxy-delta 44-58 peroxisome proliferator activated receptor gamma Homo sapiens 25-34 12524224-3 2003 METHODS AND RESULTS: The PPARgamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) or ciglitazone, stimulated a PPAR response element-luciferase reporter construct in transfected porcine pulmonary artery endothelial cells (PAECs), demonstrating that PPARgamma was transcriptionally functional. 15-deoxy-delta 44-58 peroxisome proliferator activated receptor alpha Homo sapiens 25-29 12524224-3 2003 METHODS AND RESULTS: The PPARgamma ligands, 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) or ciglitazone, stimulated a PPAR response element-luciferase reporter construct in transfected porcine pulmonary artery endothelial cells (PAECs), demonstrating that PPARgamma was transcriptionally functional. 15-deoxy-delta 44-58 peroxisome proliferator activated receptor gamma Homo sapiens 261-270 12455057-2 2003 The purpose of our study was to examine the relationship between COX-2 (with the resulting prostaglandins E(2), PGE(2)) and PPARgamma (and its natural endogenous ligand 15-Deoxy-Delta(12,14)-prostaglandin J(2), 15d-PGJ(2)) at various stages during the development of human breast cancer and its progression to metastasis. 15-deoxy-delta 169-183 prostaglandin-endoperoxide synthase 2 Homo sapiens 65-70 11950812-6 2002 PPARgamma ligands, 15-deoxy-delta(12,)(14)-prostaglandin J2 (15d-PGJ2) and troglitazone (TGZ), suppressed DNA synthesis of HT-29 cells whereas ligands for PPARalpha and PPARdelta had no significant effects. 15-deoxy-delta 19-33 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 12237101-5 2002 However, prostaglandin (PG) A(1) and 15-deoxy-Delta(12,14) PGJ(2) (15d-PGJ(2)), which are PPARbeta and gamma ligands, respectively, were both able to decrease Fc epsilon RI expression. 15-deoxy-delta 37-51 peroxisome proliferator activated receptor delta Homo sapiens 90-98 12237101-5 2002 However, prostaglandin (PG) A(1) and 15-deoxy-Delta(12,14) PGJ(2) (15d-PGJ(2)), which are PPARbeta and gamma ligands, respectively, were both able to decrease Fc epsilon RI expression. 15-deoxy-delta 37-51 Fc epsilon receptor Ia Homo sapiens 159-172 12083801-0 2002 Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. 15-deoxy-delta 111-125 zinc fingers and homeoboxes 2 Homo sapiens 27-30 12083801-0 2002 Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. 15-deoxy-delta 111-125 mitogen-activated protein kinase kinase 7 Homo sapiens 31-34 12083801-0 2002 Superoxide anion-dependent Raf/MEK/ERK activation by peroxisome proliferator activated receptor gamma agonists 15-deoxy-delta(12,14)-prostaglandin J(2), ciglitazone, and GW1929. 15-deoxy-delta 111-125 mitogen-activated protein kinase 1 Homo sapiens 35-38 12065695-7 2002 Rheumatoid synovial cells expressed PPARgamma mRNA, and the PPARgamma ligands 15-deoxy-Delta(12,14)-prostaglandin J(2) and troglitazone reduced the proliferation and induced apoptosis in synovial cells. 15-deoxy-delta 78-92 peroxisome proliferator activated receptor gamma Homo sapiens 60-69 11950812-6 2002 PPARgamma ligands, 15-deoxy-delta(12,)(14)-prostaglandin J2 (15d-PGJ2) and troglitazone (TGZ), suppressed DNA synthesis of HT-29 cells whereas ligands for PPARalpha and PPARdelta had no significant effects. 15-deoxy-delta 19-33 peroxisome proliferator activated receptor alpha Homo sapiens 155-164 11950812-6 2002 PPARgamma ligands, 15-deoxy-delta(12,)(14)-prostaglandin J2 (15d-PGJ2) and troglitazone (TGZ), suppressed DNA synthesis of HT-29 cells whereas ligands for PPARalpha and PPARdelta had no significant effects. 15-deoxy-delta 19-33 peroxisome proliferator activated receptor delta Homo sapiens 169-178 11971025-0 2002 Selective inhibition of cyclooxygenase-2 expression by 15-deoxy-Delta(12,14)(12,14)-prostaglandin J(2) in activated human astrocytes, but not in human brain macrophages. 15-deoxy-delta 55-69 prostaglandin-endoperoxide synthase 2 Homo sapiens 24-40 12269390-3 2002 In the present report, we show that the expression of PPARgamma was significantly increased in tumor tissues from human colon cancer compared with non-tumor tissues and that PPARgamma ligands, 15-Deoxy-delta(12,14)prostaglandin J2 or ciglitizone, induced apoptosis in HT-29 cells, a human colon cancer cell line. 15-deoxy-delta 193-207 peroxisome proliferator activated receptor gamma Homo sapiens 54-63 12269390-3 2002 In the present report, we show that the expression of PPARgamma was significantly increased in tumor tissues from human colon cancer compared with non-tumor tissues and that PPARgamma ligands, 15-Deoxy-delta(12,14)prostaglandin J2 or ciglitizone, induced apoptosis in HT-29 cells, a human colon cancer cell line. 15-deoxy-delta 193-207 peroxisome proliferator activated receptor gamma Homo sapiens 174-183 11786541-2 2002 Prostaglandin D(2) (PGD(2)), a major cyclooxygenase product in a variety of tissues, readily undergoes dehydration to yield the cyclopentenone-type PGs of the J(2) series, such as 15-deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), which have been suggested to exert anti-inflammatory effects in vivo. 15-deoxy-delta 180-194 phosphoglycerate dehydrogenase Homo sapiens 20-23 11973610-2 2002 In the present study, we showed that human leukemic cell lines, not only myeloid but also lymphoid, express PPAR gamma and its activation by natural ligand (15-deoxy-Delta(12,14) - prostaglandin J(2)) and synthetic ligand (troglitazone) profoundly inhibited their proliferation by induction of apoptosis preferentially in the serum-free culture. 15-deoxy-delta 157-171 peroxisome proliferator activated receptor gamma Homo sapiens 108-118 11987982-7 2002 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), a natural PPAR-gamma agonist, has a dose-dependent antiproliferative and cytotoxic effect on normal and malignant B cells as shown by [(3)H]thymidine and MTT assays. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 53-63 11901217-10 2002 15-Deoxy-Delta(12,14)-PGJ(2) and ciglitazone, which are, respectively, natural and synthetic ligands for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), inhibited LPS-induced sPLA(2)-IIA synthesis, whereas PPAR-alpha ligands were ineffective. 15-deoxy-delta 0-14 peroxisome proliferator-activated receptor gamma Cavia porcellus 105-153 11901217-10 2002 15-Deoxy-Delta(12,14)-PGJ(2) and ciglitazone, which are, respectively, natural and synthetic ligands for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), inhibited LPS-induced sPLA(2)-IIA synthesis, whereas PPAR-alpha ligands were ineffective. 15-deoxy-delta 0-14 peroxisome proliferator-activated receptor gamma Cavia porcellus 155-165 11901217-10 2002 15-Deoxy-Delta(12,14)-PGJ(2) and ciglitazone, which are, respectively, natural and synthetic ligands for peroxisome proliferator-activated receptor-gamma (PPAR-gamma), inhibited LPS-induced sPLA(2)-IIA synthesis, whereas PPAR-alpha ligands were ineffective. 15-deoxy-delta 0-14 peroxisome proliferator-activated receptor alpha Cavia porcellus 221-231 11401318-3 2001 All cell lines were found to express functionally active PPARgamma and a marked growth inhibition was induced by thiazolidinedione ligands troglitazone, and pioglitazone as well as with its natural ligand 15-deoxy-Delta(12,14)-prostaglandin J(2). 15-deoxy-delta 205-219 peroxisome proliferator activated receptor gamma Homo sapiens 57-66 11864843-3 2002 This review focuses on recent findings concerning prostaglandin E2 (PGE2) and the PGD2 metabolite 15-deoxy-Delta(12,14)-PGJ2, and their divergent roles in immune regulation. 15-deoxy-delta 98-112 prostaglandin D2 synthase Homo sapiens 82-86 11742805-3 2002 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) dose-dependently decreased LPS-induced cyclooxygenase (COX)-2 (-80%) and inducible nitric oxide synthase (iNOS) mRNA expression (-80%), whereas troglitazone (10 microM) only inhibited iNOS mRNA expression (-50%). 15-deoxy-delta 0-14 nitric oxide synthase 2 Rattus norvegicus 127-158 11742805-3 2002 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) dose-dependently decreased LPS-induced cyclooxygenase (COX)-2 (-80%) and inducible nitric oxide synthase (iNOS) mRNA expression (-80%), whereas troglitazone (10 microM) only inhibited iNOS mRNA expression (-50%). 15-deoxy-delta 0-14 nitric oxide synthase 2 Rattus norvegicus 160-164 11742805-3 2002 15-Deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) dose-dependently decreased LPS-induced cyclooxygenase (COX)-2 (-80%) and inducible nitric oxide synthase (iNOS) mRNA expression (-80%), whereas troglitazone (10 microM) only inhibited iNOS mRNA expression (-50%). 15-deoxy-delta 0-14 nitric oxide synthase 2 Rattus norvegicus 238-242 11872377-4 2002 Recently, synthetic antidiabetic thiazolidinediones (TZDs) and the natural prostaglandin D2 (PGD2) metabolite, 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2), have been identified as ligands for PPARgamma. 15-deoxy-delta 111-125 peroxisome proliferator activated receptor gamma Homo sapiens 198-207 11668172-2 2001 Several investigators have shown that the terminal derivative of prostaglandin J(2) (PGJ(2)) metabolism, 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)), induces apoptosis in breast cancer cells and is a potent activator of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but 15dPGJ(2) effects can be mediated by PPARgamma-dependent and PPARgamma-independent mechanisms. 15-deoxy-delta 105-119 peroxisome proliferator activated receptor gamma Homo sapiens 296-305 11668172-2 2001 Several investigators have shown that the terminal derivative of prostaglandin J(2) (PGJ(2)) metabolism, 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)), induces apoptosis in breast cancer cells and is a potent activator of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but 15dPGJ(2) effects can be mediated by PPARgamma-dependent and PPARgamma-independent mechanisms. 15-deoxy-delta 105-119 peroxisome proliferator activated receptor gamma Homo sapiens 349-358 11668172-2 2001 Several investigators have shown that the terminal derivative of prostaglandin J(2) (PGJ(2)) metabolism, 15-deoxy-Delta(12,14)-PGJ(2) (15dPGJ(2)), induces apoptosis in breast cancer cells and is a potent activator of the nuclear hormone receptor peroxisome proliferator-activated receptor gamma (PPARgamma), but 15dPGJ(2) effects can be mediated by PPARgamma-dependent and PPARgamma-independent mechanisms. 15-deoxy-delta 105-119 peroxisome proliferator activated receptor gamma Homo sapiens 349-358 11890746-1 2002 15-deoxy-delta (12,14)prostaglandin J(2) (15d-PGJ(2)) has been identified as a natural ligand of the PPARgamma subtype. 15-deoxy-delta 0-14 peroxisome proliferator-activated receptor gamma Rattus norvegicus 101-110 11278336-2 2001 We investigated whether peroxisome proliferator-activated receptor gamma (PPARgamma) ligands (ciglitazone, troglitazone, and 15-deoxy-Delta(12,14) prostaglandin J(2)) inhibited cyclooxygenase-2 (COX-2) induction in human epithelial cells. 15-deoxy-delta 125-139 peroxisome proliferator activated receptor gamma Homo sapiens 24-72 11390455-1 2001 Ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), such as 15-deoxy-Delta(12,14)PGJ2 (15d-PGJ2) have been proposed as a new class of antiinflammatory compounds with possible clinical applications. 15-deoxy-delta 82-96 peroxisome proliferator activated receptor gamma Homo sapiens 12-60 11390455-1 2001 Ligands for peroxisome proliferator-activated receptor gamma (PPARgamma), such as 15-deoxy-Delta(12,14)PGJ2 (15d-PGJ2) have been proposed as a new class of antiinflammatory compounds with possible clinical applications. 15-deoxy-delta 82-96 peroxisome proliferator activated receptor gamma Homo sapiens 62-71 11278336-2 2001 We investigated whether peroxisome proliferator-activated receptor gamma (PPARgamma) ligands (ciglitazone, troglitazone, and 15-deoxy-Delta(12,14) prostaglandin J(2)) inhibited cyclooxygenase-2 (COX-2) induction in human epithelial cells. 15-deoxy-delta 125-139 peroxisome proliferator activated receptor gamma Homo sapiens 74-83 11278336-2 2001 We investigated whether peroxisome proliferator-activated receptor gamma (PPARgamma) ligands (ciglitazone, troglitazone, and 15-deoxy-Delta(12,14) prostaglandin J(2)) inhibited cyclooxygenase-2 (COX-2) induction in human epithelial cells. 15-deoxy-delta 125-139 prostaglandin-endoperoxide synthase 2 Homo sapiens 177-193 11278336-2 2001 We investigated whether peroxisome proliferator-activated receptor gamma (PPARgamma) ligands (ciglitazone, troglitazone, and 15-deoxy-Delta(12,14) prostaglandin J(2)) inhibited cyclooxygenase-2 (COX-2) induction in human epithelial cells. 15-deoxy-delta 125-139 prostaglandin-endoperoxide synthase 2 Homo sapiens 195-200 11401521-5 2001 In contrast, both troglitazone (at 10 microM) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2), at 15 microM), a natural ligand for PPARgamma, induce c-Jun phosphorylation by activation of c-Jun N-terminal kinase (JNK) through a posttranslational regulation of c-Jun activity, therefore increasing AP-1/DNA binding activity and transcriptional responses as results of increasing basal ICAM-1 gene expression. 15-deoxy-delta 50-64 peroxisome proliferator activated receptor gamma Homo sapiens 140-149 11401521-5 2001 In contrast, both troglitazone (at 10 microM) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2), at 15 microM), a natural ligand for PPARgamma, induce c-Jun phosphorylation by activation of c-Jun N-terminal kinase (JNK) through a posttranslational regulation of c-Jun activity, therefore increasing AP-1/DNA binding activity and transcriptional responses as results of increasing basal ICAM-1 gene expression. 15-deoxy-delta 50-64 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 158-163 11401521-5 2001 In contrast, both troglitazone (at 10 microM) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2), at 15 microM), a natural ligand for PPARgamma, induce c-Jun phosphorylation by activation of c-Jun N-terminal kinase (JNK) through a posttranslational regulation of c-Jun activity, therefore increasing AP-1/DNA binding activity and transcriptional responses as results of increasing basal ICAM-1 gene expression. 15-deoxy-delta 50-64 mitogen-activated protein kinase 8 Homo sapiens 197-220 11401521-5 2001 In contrast, both troglitazone (at 10 microM) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2), at 15 microM), a natural ligand for PPARgamma, induce c-Jun phosphorylation by activation of c-Jun N-terminal kinase (JNK) through a posttranslational regulation of c-Jun activity, therefore increasing AP-1/DNA binding activity and transcriptional responses as results of increasing basal ICAM-1 gene expression. 15-deoxy-delta 50-64 mitogen-activated protein kinase 8 Homo sapiens 222-225 11401521-5 2001 In contrast, both troglitazone (at 10 microM) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2), at 15 microM), a natural ligand for PPARgamma, induce c-Jun phosphorylation by activation of c-Jun N-terminal kinase (JNK) through a posttranslational regulation of c-Jun activity, therefore increasing AP-1/DNA binding activity and transcriptional responses as results of increasing basal ICAM-1 gene expression. 15-deoxy-delta 50-64 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 197-202 11401521-5 2001 In contrast, both troglitazone (at 10 microM) and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2), at 15 microM), a natural ligand for PPARgamma, induce c-Jun phosphorylation by activation of c-Jun N-terminal kinase (JNK) through a posttranslational regulation of c-Jun activity, therefore increasing AP-1/DNA binding activity and transcriptional responses as results of increasing basal ICAM-1 gene expression. 15-deoxy-delta 50-64 intercellular adhesion molecule 1 Homo sapiens 393-399 10827178-2 2000 The PGD(2) metabolite 15-deoxy-Delta(12, 14) PGJ(2) (15d-PGJ(2)) was identified as a potent natural ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). 15-deoxy-delta 22-36 peroxisome proliferator activated receptor gamma Homo sapiens 115-163 11278956-5 2001 PPARgamma activators, troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), inhibited IL-1beta-induced PDGFalphaR expression and suppressed PDGF-induced proliferation activity of VSMCs. 15-deoxy-delta 39-53 peroxisome proliferator activated receptor gamma Homo sapiens 0-9 11278956-5 2001 PPARgamma activators, troglitazone and 15-deoxy-Delta(12,14)-prostaglandin J(2), inhibited IL-1beta-induced PDGFalphaR expression and suppressed PDGF-induced proliferation activity of VSMCs. 15-deoxy-delta 39-53 interleukin 1 beta Homo sapiens 91-99 11159824-0 2001 Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. 15-deoxy-delta 95-109 albumin Homo sapiens 0-7 11159824-0 2001 Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. 15-deoxy-delta 95-109 peroxisome proliferator activated receptor gamma Homo sapiens 31-79 11159824-0 2001 Albumin regulates induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-delta(12-14)-prostaglandin J(2) in vitro and may be an important regulator of PPARgamma function in vivo. 15-deoxy-delta 95-109 peroxisome proliferator activated receptor gamma Homo sapiens 81-90 11159824-1 2001 We observed that serum contains a factor(s) that inhibits the induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-Delta(12,14)-PGJ(2) (15dJ(2)). 15-deoxy-delta 139-153 peroxisome proliferator activated receptor gamma Homo sapiens 75-123 11159824-1 2001 We observed that serum contains a factor(s) that inhibits the induction of peroxisome proliferator-activated receptor-gamma (PPARgamma) by 15-deoxy-Delta(12,14)-PGJ(2) (15dJ(2)). 15-deoxy-delta 139-153 peroxisome proliferator activated receptor gamma Homo sapiens 125-134 11164379-5 2001 In contrast, heme oxygenase-1 was induced by 15-deoxy-Delta(12,14) prostaglandin J(2) alone, but was not changed by interleukin-4 or lipopolysaccharide. 15-deoxy-delta 45-59 heme oxygenase 1 Mus musculus 13-29 11204739-4 2001 Transforming growth factor-beta (1 ng/ml) and 15-deoxy-delta(12,14) prostaglandin J2 (1 microM) significantly (P < 0.05) (33% and 44% respectively) increased PGHS-1 promoter activity. 15-deoxy-delta 46-60 prostaglandin-endoperoxide synthase 1 Homo sapiens 161-167 10827178-2 2000 The PGD(2) metabolite 15-deoxy-Delta(12, 14) PGJ(2) (15d-PGJ(2)) was identified as a potent natural ligand for the peroxisome proliferator-activated receptor-gamma (PPARgamma). 15-deoxy-delta 22-36 peroxisome proliferator activated receptor gamma Homo sapiens 165-174 10936413-0 2000 15-deoxy-Delta(12,14)PGJ(2) induces diverse biological responses via PPARgamma activation in cancer cells. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 69-78 11094980-6 2000 The recombinant protein of OPR3 cross-reacted with an antiserum raised against the OYE protein, and showed oxidation of beta-NADPH when OPDA or 15-deoxy-delta(12,14) prostaglandin J2 (PGJ2), an analogue of OPDA, was used as substrate. 15-deoxy-delta 144-158 oxophytodienoate-reductase 3 Arabidopsis thaliana 27-31 10807869-1 2000 Ligands for peroxisome proliferator-activated receptor gamma, such as the thiazolidinedione class of antidiabetic drugs and 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), modulate various processes in atherogenesis. 15-deoxy-delta 124-138 peroxisome proliferator activated receptor gamma Homo sapiens 12-60 10799521-5 2000 CD34(+) HSCs, but not hMSCs, express PPAR-gamma, and 15-deoxy-Delta(12, 14)-prostaglandin-J2 (15d-PG-J2), a PPAR-gamma agonist, completely blocked the effects of sOPGL and M-CSF on Ocl formation and activity. 15-deoxy-delta 53-67 CD34 molecule Homo sapiens 0-4 10935488-6 1999 Addition of the RXRalpha ligands, 9-cis-RA or LG100268, sensitized T24 bladder cancer cells to the lethal effect of troglitazone and two other PPAR- activators, ciglitazone and 15-deoxy-delta(12,14)-PGJ2 (15dPGJ(2)). 15-deoxy-delta 177-191 retinoid X receptor alpha Homo sapiens 16-24 10671476-5 2000 Here we show that PPARgamma ligands, troglitazone and 15-deoxy-Delta(12,14) prostaglandin J(2), but not PPARalpha agonist Wy14643, inhibited IL-2 production and phytohemagglutinin-inducible proliferation in human peripheral blood T-cells in a dose-dependent manner. 15-deoxy-delta 54-68 peroxisome proliferator activated receptor gamma Homo sapiens 18-27 10671476-5 2000 Here we show that PPARgamma ligands, troglitazone and 15-deoxy-Delta(12,14) prostaglandin J(2), but not PPARalpha agonist Wy14643, inhibited IL-2 production and phytohemagglutinin-inducible proliferation in human peripheral blood T-cells in a dose-dependent manner. 15-deoxy-delta 54-68 interleukin 2 Homo sapiens 141-145 11030710-4 2000 ECV-ACO.Luc respond to the PPARgamma agonists, 15-deoxy-Delta(12,14) PGJ(2), and ciglitizone, by inducing luciferase expression. 15-deoxy-delta 47-61 peroxisome proliferator activated receptor gamma Homo sapiens 27-36 24370048-1 2013 15-Deoxy-Delta(12), 14-prostaglandin J2 (15d-PGJ2), a well known peroxisome proliferator activated receptor (PPAR) gamma ligand, has been shown to inhibit cellular proliferation and induce apoptosis and differentiation. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor alpha Homo sapiens 65-107 24370048-1 2013 15-Deoxy-Delta(12), 14-prostaglandin J2 (15d-PGJ2), a well known peroxisome proliferator activated receptor (PPAR) gamma ligand, has been shown to inhibit cellular proliferation and induce apoptosis and differentiation. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor alpha Homo sapiens 109-113 10203248-1 1999 The peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by 15-deoxy-delta(12,14) prostaglandin J2 (15d-PGJ2), anti-diabetic thiazolidinediones and several non-steroidal anti-inflammatory drugs (NSAIDs). 15-deoxy-delta 81-95 peroxisome proliferator-activated receptor gamma Rattus norvegicus 4-52 10203248-1 1999 The peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by 15-deoxy-delta(12,14) prostaglandin J2 (15d-PGJ2), anti-diabetic thiazolidinediones and several non-steroidal anti-inflammatory drugs (NSAIDs). 15-deoxy-delta 81-95 peroxisome proliferator-activated receptor gamma Rattus norvegicus 54-63 24337644-1 2014 A well-recognized natural ligand of PPARgamma, 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) possesses immunomodulatory properties. 15-deoxy-delta 47-61 peroxisome proliferator activated receptor gamma Homo sapiens 36-45 32215785-5 2020 MCs support angiogenesis in AT by releasing chymase and inducing preadipocyte differentiation and also the proliferation of adipocytes through 15-deoxy-delta PGJ2/PPARgamma interaction. 15-deoxy-delta 143-157 peroxisome proliferator activated receptor gamma Homo sapiens 163-172 25449421-3 2015 IGFBP-3 and the PPARgamma ligands, rosiglitazone or 15-deoxy-Delta(12,14)-prostaglandin J2, separately inhibited the proliferation of MCF-7, MDA-MB-231 and MDA-MB-468 breast cancer cells. 15-deoxy-delta 52-66 peroxisome proliferator activated receptor gamma Homo sapiens 16-25 25072357-3 2014 In this manuscript, we report that the 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), peroxisome proliferator-activated receptor gamma (PPARgamma) activator leads to the downregulation of the cancer-associated expression of B7-H1 in response to interferon-gamma (IFN-gamma) and the associated signaling cascades. 15-deoxy-delta 39-53 peroxisome proliferator activated receptor gamma Mus musculus 90-138 25072357-3 2014 In this manuscript, we report that the 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), peroxisome proliferator-activated receptor gamma (PPARgamma) activator leads to the downregulation of the cancer-associated expression of B7-H1 in response to interferon-gamma (IFN-gamma) and the associated signaling cascades. 15-deoxy-delta 39-53 peroxisome proliferator activated receptor gamma Mus musculus 140-149 25072357-3 2014 In this manuscript, we report that the 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), peroxisome proliferator-activated receptor gamma (PPARgamma) activator leads to the downregulation of the cancer-associated expression of B7-H1 in response to interferon-gamma (IFN-gamma) and the associated signaling cascades. 15-deoxy-delta 39-53 CD274 antigen Mus musculus 228-233 25072357-3 2014 In this manuscript, we report that the 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), peroxisome proliferator-activated receptor gamma (PPARgamma) activator leads to the downregulation of the cancer-associated expression of B7-H1 in response to interferon-gamma (IFN-gamma) and the associated signaling cascades. 15-deoxy-delta 39-53 interferon gamma Mus musculus 249-265 25072357-3 2014 In this manuscript, we report that the 15-deoxy-delta(12,14)-prostaglandin J2 (15d-PGJ2), peroxisome proliferator-activated receptor gamma (PPARgamma) activator leads to the downregulation of the cancer-associated expression of B7-H1 in response to interferon-gamma (IFN-gamma) and the associated signaling cascades. 15-deoxy-delta 39-53 interferon gamma Mus musculus 267-276 24680891-1 2014 A ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) induces apoptosis in various cells. 15-deoxy-delta 74-88 peroxisome proliferator-activated receptor gamma Oryctolagus cuniculus 12-60 26115075-6 2015 In cultured cells, endogenous GPx2 expression and GPx2 promoter activity were enhanced by the anti-inflammatory mediators 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and interleukin-22 (IL-22), while it was unaffected by classical proinflammatory cytokines like IL-1beta. 15-deoxy-delta 122-136 glutathione peroxidase 2 Mus musculus 30-34 26115075-6 2015 In cultured cells, endogenous GPx2 expression and GPx2 promoter activity were enhanced by the anti-inflammatory mediators 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and interleukin-22 (IL-22), while it was unaffected by classical proinflammatory cytokines like IL-1beta. 15-deoxy-delta 122-136 glutathione peroxidase 2 Mus musculus 50-54 26115075-6 2015 In cultured cells, endogenous GPx2 expression and GPx2 promoter activity were enhanced by the anti-inflammatory mediators 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and interleukin-22 (IL-22), while it was unaffected by classical proinflammatory cytokines like IL-1beta. 15-deoxy-delta 122-136 interleukin 22 Mus musculus 192-197 26115075-6 2015 In cultured cells, endogenous GPx2 expression and GPx2 promoter activity were enhanced by the anti-inflammatory mediators 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) and interleukin-22 (IL-22), while it was unaffected by classical proinflammatory cytokines like IL-1beta. 15-deoxy-delta 122-136 interleukin 1 beta Mus musculus 268-276 24680891-1 2014 A ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), 15-deoxy-Delta(12,14)-prostaglandin J2 (15d-PGJ2) induces apoptosis in various cells. 15-deoxy-delta 74-88 peroxisome proliferator-activated receptor gamma Oryctolagus cuniculus 62-71 22307523-6 2012 MC3T3-E1 preosteoblasts transfected with MEF secreted higher levels of 15-deoxy-delta (12, 14)-prostaglandin J(2), a potent endogenous ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), under adipogenic conditions. 15-deoxy-delta 71-85 E74-like factor 4 (ets domain transcription factor) Mus musculus 41-44 22307523-6 2012 MC3T3-E1 preosteoblasts transfected with MEF secreted higher levels of 15-deoxy-delta (12, 14)-prostaglandin J(2), a potent endogenous ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), under adipogenic conditions. 15-deoxy-delta 71-85 peroxisome proliferator activated receptor gamma Mus musculus 145-193 22307523-6 2012 MC3T3-E1 preosteoblasts transfected with MEF secreted higher levels of 15-deoxy-delta (12, 14)-prostaglandin J(2), a potent endogenous ligand of peroxisome proliferator-activated receptor gamma (PPARgamma), under adipogenic conditions. 15-deoxy-delta 71-85 peroxisome proliferator activated receptor gamma Mus musculus 195-204 21511917-3 2011 The objective of the present studies was to examine whether 15-deoxy-Delta(12,14)-PGJ(2)-glycerol ester (15d-PGJ(2)-G), a putative metabolite of 2-AG, can mimic the actions of 2-AG on IL-2 regulation through PPARgamma activation. 15-deoxy-delta 60-74 interleukin 2 Homo sapiens 184-188 21511917-3 2011 The objective of the present studies was to examine whether 15-deoxy-Delta(12,14)-PGJ(2)-glycerol ester (15d-PGJ(2)-G), a putative metabolite of 2-AG, can mimic the actions of 2-AG on IL-2 regulation through PPARgamma activation. 15-deoxy-delta 60-74 peroxisome proliferator activated receptor gamma Homo sapiens 208-217 21236332-2 2011 15-Deoxy-Delta(12,14)-PGJ(2) (15d-PGJ(2)), a metabolite of PGD(2) and PPARgamma-ligand, exerts a panel of biological activities via receptor-dependent and -independent mechanisms. 15-deoxy-delta 0-14 peroxisome proliferator activated receptor gamma Homo sapiens 70-79 22469179-4 2012 BALB/c (H-2(d)) islets in which PPARgamma activity was induced by its agonists, 15-deoxy-Delta(12-14)-prostaglandin J(2) (15d-PGJ(2)) or troglitazone were transplanted into C57BL/6 (H-2(b)) recipients that had been rendered diabetic by streptozotocin (STZ). 15-deoxy-delta 80-94 peroxisome proliferator activated receptor gamma Homo sapiens 32-41 22991494-2 2012 The aim was to investigate the cytotoxicity and action mechanisms of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), one of endogenous ligands for PPARgamma, in terms of PPARgamma-dependency and the mitogen-activated protein kinase (MAPK) and Akt pathway in three human renal cell carcinoma (RCC)-derived cell lines. 15-deoxy-delta 69-83 peroxisome proliferator activated receptor gamma Homo sapiens 154-163 22991494-2 2012 The aim was to investigate the cytotoxicity and action mechanisms of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), one of endogenous ligands for PPARgamma, in terms of PPARgamma-dependency and the mitogen-activated protein kinase (MAPK) and Akt pathway in three human renal cell carcinoma (RCC)-derived cell lines. 15-deoxy-delta 69-83 peroxisome proliferator activated receptor gamma Homo sapiens 177-186 22991494-2 2012 The aim was to investigate the cytotoxicity and action mechanisms of 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), one of endogenous ligands for PPARgamma, in terms of PPARgamma-dependency and the mitogen-activated protein kinase (MAPK) and Akt pathway in three human renal cell carcinoma (RCC)-derived cell lines. 15-deoxy-delta 69-83 AKT serine/threonine kinase 1 Homo sapiens 250-253 21924248-4 2011 Here we report that VLDLR expression in 3T3-L1 adipocytes is upregulated by PPARgamma agonist 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) in dose- and time-dependant manners. 15-deoxy-delta 94-108 very low density lipoprotein receptor Mus musculus 20-25 21924248-4 2011 Here we report that VLDLR expression in 3T3-L1 adipocytes is upregulated by PPARgamma agonist 15-deoxy-delta(12,14)-prostaglandin J(2) (15d-PGJ(2)) in dose- and time-dependant manners. 15-deoxy-delta 94-108 peroxisome proliferator activated receptor gamma Mus musculus 76-85 21683069-3 2011 An endogenous ligand for peroxisome proliferator-activated receptor-gamma (PPARgamma), 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), induces apoptosis in RCC. 15-deoxy-delta 87-101 peroxisome proliferator activated receptor gamma Homo sapiens 25-73