PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35356048-3	2022	Methods: & Results: Human embryonic kidney (HEK293) cells with inducible RyR2 expression were treated with the cGMP analogue 8-Br-cGMP (100 muM) to activate endogenous PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	125-134	ryanodine receptor 2	Homo sapiens	73-77
34750765-6	2021	Further studies suggested that SCU (10-1000 microM) dose-dependently induced relaxation in isolated BA rings which were significantly blocked by the cGMP dependent protein kinase (PKG) inhibitor Rp-8-Br-cGMPs (PKGI-rp, 4 microM).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	195-208	KIT proto-oncogene receptor tyrosine kinase	Rattus norvegicus	164-178
34750765-6	2021	Further studies suggested that SCU (10-1000 microM) dose-dependently induced relaxation in isolated BA rings which were significantly blocked by the cGMP dependent protein kinase (PKG) inhibitor Rp-8-Br-cGMPs (PKGI-rp, 4 microM).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	195-208	protein kinase cGMP-dependent 1	Rattus norvegicus	210-214
35356048-3	2022	Methods: & Results: Human embryonic kidney (HEK293) cells with inducible RyR2 expression were treated with the cGMP analogue 8-Br-cGMP (100 muM) to activate endogenous PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	125-134	protein kinase cGMP-dependent 1	Homo sapiens	168-171
35356048-6	2022	Interestingly, despite a functional dependence on expression of RyR2 phosphorylation sites, 8-Br-cGMP activation of PKG did not promote a detectable change in S2808 phosphorylation (P = 0.9).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	92-101	protein kinase cGMP-dependent 1	Homo sapiens	116-119
6318567-5	1983	8BrcGMP was found to produce a weak stimulation of both acid and pepsinogen secretions, while GMP, cGMP, and DBcGMP were ineffective.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-7	pepsin II-2/3	Oryctolagus cuniculus	65-75
2563941-3	1989	The hormonal response to corticotropin-releasing factor (10(-10) mol/l), vasopressin (10(-9) mol/l) as well as KC1 (48 mmol/l) was reduced by membrane permeant analogs of cGMP, such as 8-BrcGMP and dibutyryl-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	185-193	corticotropin releasing hormone	Rattus norvegicus	25-55
2563941-3	1989	The hormonal response to corticotropin-releasing factor (10(-10) mol/l), vasopressin (10(-9) mol/l) as well as KC1 (48 mmol/l) was reduced by membrane permeant analogs of cGMP, such as 8-BrcGMP and dibutyryl-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	185-193	arginine vasopressin	Rattus norvegicus	73-84
2563941-4	1989	The 8-BrcGMP analog (10(-5) mol/l) inhibited corticotropin release in response to corticotropin-releasing factor by 30%, that to vasopressin by 70%, and that to KCl by 50%.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	4-12	corticotropin releasing hormone	Rattus norvegicus	82-112
2563941-4	1989	The 8-BrcGMP analog (10(-5) mol/l) inhibited corticotropin release in response to corticotropin-releasing factor by 30%, that to vasopressin by 70%, and that to KCl by 50%.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	4-12	arginine vasopressin	Rattus norvegicus	129-140
2982853-3	1985	Two other cGMP derivatives, 8-bromoguanosine 3":5"-cyclic monophosphate (8-Br-cGMP) and 2"-deoxy-cGMP, were also potent stimulators of elastin synthesis.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	73-82	elastin	Homo sapiens	135-142
2982853-7	1985	When 8-Br-cGMP was added to cells together with Bt2cAMP, cGMP-dependent stimulation of elastin production was abolished by cAMP in a dose-dependent fashion.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	5-14	elastin	Homo sapiens	87-94
2463255-13	1989	At concentrations above 0.1 mM, 8Br-cGMP augmented the stimulation of amylase release caused by CCK-8, carbachol, bombesin, or TPA.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	32-40	cholecystokinin	Rattus norvegicus	96-99
166157-5	1975	A concomitant outflow of DBH activity was observed in the presence of mbcAMP, 8-Br-cGMP or Ro 20-1724.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	78-87	dopamine beta-hydroxylase	Homo sapiens	25-28
31434939-7	2019	VSMC stimulation with GSNO, a nitric oxide analogue or with 8-br-cGMP, but not with 8-br-cAMP, up-regulated PDE5 and NOTCH-3 protein levels, indicating a negative feedback loop to protect the arterial wall from excessive relaxation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	60-69	phosphodiesterase 5A	Homo sapiens	108-112
32466182-11	2020	The sGC inhibitior, ODQ, abolished the nitrate-barbiturate inhibition of MMP-9 gene expression, an effect which was reversed by 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	128-137	matrix metallopeptidase 9	Homo sapiens	73-78
31434939-7	2019	VSMC stimulation with GSNO, a nitric oxide analogue or with 8-br-cGMP, but not with 8-br-cAMP, up-regulated PDE5 and NOTCH-3 protein levels, indicating a negative feedback loop to protect the arterial wall from excessive relaxation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	60-69	notch receptor 3	Homo sapiens	117-124
30104414-7	2018	In addition, TNFalpha-induced miR-155-5p inhibited the vasorelaxant response of de-endothelialized mouse aortic vessels to 8-Br-cGMP by suppressing phosphorylation of myosin phosphatase and myosin light chain, both of which are downstream signal modulators of PKG1.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	123-132	tumor necrosis factor	Mus musculus	13-21
31030607-6	2019	The cell-permeable second messenger analogs of cAMP (8-Br-cAMP) or cGMP (8-Br-cGMP) induce translocation of both D1R and AT2R to the plasma membrane.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	73-82	angiotensin II receptor type 2	Homo sapiens	121-125
31030607-8	2019	Both 8-Br-cAMP and 8-Br-cGMP activate PP2A (protein phosphatase 2A), which is necessary for both plasma membrane recruitment of D1R and AT2R and the inhibition of sodium hydrogen exchanger 3-dependent Na+ transport.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	19-28	protein phosphatase 2 phosphatase activator	Homo sapiens	38-42
31030607-8	2019	Both 8-Br-cAMP and 8-Br-cGMP activate PP2A (protein phosphatase 2A), which is necessary for both plasma membrane recruitment of D1R and AT2R and the inhibition of sodium hydrogen exchanger 3-dependent Na+ transport.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	19-28	angiotensin II receptor type 2	Homo sapiens	136-140
30585261-7	2018	The cGMP analog 8-Br-cGMP blocked H2O2-induced apoptotic cell death; reduction of caspase-3 enzyme, cytochrome c release, and caspase-8 and -9.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	16-25	caspase 3	Homo sapiens	82-91
30585261-7	2018	The cGMP analog 8-Br-cGMP blocked H2O2-induced apoptotic cell death; reduction of caspase-3 enzyme, cytochrome c release, and caspase-8 and -9.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	16-25	cytochrome c, somatic	Homo sapiens	100-112
30585261-7	2018	The cGMP analog 8-Br-cGMP blocked H2O2-induced apoptotic cell death; reduction of caspase-3 enzyme, cytochrome c release, and caspase-8 and -9.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	16-25	caspase 8	Homo sapiens	126-142
30585261-8	2018	These preventive effects of SNAP and 8-Br-cGMP were suppressed by PKG inhibitor KT5823.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	37-46	protein kinase cGMP-dependent 1	Homo sapiens	66-69
30104414-7	2018	In addition, TNFalpha-induced miR-155-5p inhibited the vasorelaxant response of de-endothelialized mouse aortic vessels to 8-Br-cGMP by suppressing phosphorylation of myosin phosphatase and myosin light chain, both of which are downstream signal modulators of PKG1.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	123-132	microRNA 155	Mus musculus	30-37
29720615-4	2018	The present study showed that treatment of embryonic ventricular cells with ANP or cell permeable 8-Br-cGMP can induce gene expression of important VCS markers such as hyperpolarization-activated cyclic nucleotide-gated channel-4 (HCN4) and connexin 40 (Cx40).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	98-107	hyperpolarization activated cyclic nucleotide gated potassium channel 4	Homo sapiens	168-229
29574150-4	2018	Treatment of intact and defolliculated oocytes with 100 nM NPPC for 6 h caused a large increase in cGMP concentrations, and a significant decrease in oocyte maturation (OM), an effect that was mimicked by treatment with 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	220-229	natriuretic peptide C	Danio rerio	59-63
29720615-4	2018	The present study showed that treatment of embryonic ventricular cells with ANP or cell permeable 8-Br-cGMP can induce gene expression of important VCS markers such as hyperpolarization-activated cyclic nucleotide-gated channel-4 (HCN4) and connexin 40 (Cx40).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	98-107	hyperpolarization activated cyclic nucleotide gated potassium channel 4	Homo sapiens	231-235
29720615-4	2018	The present study showed that treatment of embryonic ventricular cells with ANP or cell permeable 8-Br-cGMP can induce gene expression of important VCS markers such as hyperpolarization-activated cyclic nucleotide-gated channel-4 (HCN4) and connexin 40 (Cx40).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	98-107	gap junction protein alpha 5	Homo sapiens	241-252
29720615-4	2018	The present study showed that treatment of embryonic ventricular cells with ANP or cell permeable 8-Br-cGMP can induce gene expression of important VCS markers such as hyperpolarization-activated cyclic nucleotide-gated channel-4 (HCN4) and connexin 40 (Cx40).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	98-107	gap junction protein alpha 5	Homo sapiens	254-258
29165873-8	2018	Concomitantly, the HO-1 byproduct CO and the cGMP analogue 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) increased MKP-5 expression, and pretreatment with CO and 8-Br-cGMP inhibited hypoxia-induced HIF-1alpha and ET-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	104-113	heme oxygenase 1	Homo sapiens	19-23
29165873-8	2018	Concomitantly, the HO-1 byproduct CO and the cGMP analogue 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) increased MKP-5 expression, and pretreatment with CO and 8-Br-cGMP inhibited hypoxia-induced HIF-1alpha and ET-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	104-113	dual specificity phosphatase 10	Homo sapiens	125-130
29165873-8	2018	Concomitantly, the HO-1 byproduct CO and the cGMP analogue 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) increased MKP-5 expression, and pretreatment with CO and 8-Br-cGMP inhibited hypoxia-induced HIF-1alpha and ET-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	104-113	endothelin 1	Homo sapiens	223-227
29165873-8	2018	Concomitantly, the HO-1 byproduct CO and the cGMP analogue 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) increased MKP-5 expression, and pretreatment with CO and 8-Br-cGMP inhibited hypoxia-induced HIF-1alpha and ET-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	172-181	heme oxygenase 1	Homo sapiens	19-23
26839558-11	2016	The reduction of Akt-p at Ser-473 by NTG, DETA NONOate, and 8-Br-cGMP was significantly inhibited by ODQ, PKG-I.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	60-69	AKT serine/threonine kinase 1	Homo sapiens	17-20
28807144-6	2017	Our results indicate that the CaValpha1 ion-conducting subunit of the CaV1.3 channels is highly expressed in RIN-m5F cells and that the application of 8-Br-cGMP, a membrane-permeable analogue of cGMP, significantly inhibits Ca2+ macroscopic currents and impair insulin release stimulated with high K+.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	151-160	caveolin 1	Rattus norvegicus	70-74
28807144-7	2017	In addition, KT-5823, a specific inhibitor of PKG, prevents the current inhibition generated by 8-Br-cGMP in the heterologous expression system.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	96-105	protein kinase cGMP-dependent 1	Homo sapiens	46-49
27397542-8	2016	RESULTS: In immuno-FRET experiments, after exposure of these cells to 8-Br-cGMP, more PKG1alpha was observed in the plasma membrane, and PKG1alpha and TRPC1 were observed to be in closer proximity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	70-79	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	151-156
26839558-12	2016	The decrease in Akt-p level by NTG and 8-Br-cGMP was prevented by calyculin A but not by okadaic acid.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	39-48	AKT serine/threonine kinase 1	Homo sapiens	16-19
25550561-6	2015	8-Br-cGMP, a direct activator of PKG, protects against pro-apoptotic effects of high-concentration resveratrol.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	protein kinase cGMP-dependent 1	Homo sapiens	33-36
26254861-7	2015	ME (10 muM)-induced desensitization was blocked by the neuronal NO synthase inhibitor 7-NI (100 muM) and restored by the PKG activator 8-Br-cGMP (100-300 muM).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	135-144	latexin	Homo sapiens	7-10
26016495-8	2015	Another membrane-permeable and non-hydrolyzable analog of cGMP, 8-Br-cGMP, stimulated CFTR only at millimolar concentrations, consistent with cross-activation of PKA.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	64-73	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	86-90
26016495-11	2015	CONCLUSION: From these experiments we conclude that in the Xenopus oocyte system, natriuretic peptides, 8-Br-cGMP, and PDE5 inhibitors activate CFTR by cross-activation of PKA.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	104-113	cystic fibrosis transmembrane conductance regulator L homeolog	Xenopus laevis	144-148
24306353-7	2014	Application of 1-aminocyclopropane-1-carboxylic acid (ACC, an ethylene precursor) or 8-Br-cGMP (the cGMP analog) alleviated NaCl-induced injury by maintaining a lower Na(+)/K(+) ratio and increasing PM H(+)-ATPase activity in WT, but not in etr1-3.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	85-94	Signal transduction histidine kinase, hybrid-type, ethylene sensor	Arabidopsis thaliana	241-245
25046820-5	2014	The 7-NI- or ODQ-induced effect was reversed by premicroinjection of the sGC activator YC-1 or the PKG activator 8-Br-cGMP in the NAc shell.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	113-122	protein kinase cGMP-dependent 1	Homo sapiens	99-102
24977346-6	2014	Incubation with DETA NONOate (a stable NO donor) and 8-Br-cGMP (a cell membrane permeable analog of cGMP) attenuated Akt phosphorylation at Ser-473, which was prevented by Rp-8-Br-PET-cGMPS (a specific inhibitor of PKG) and calyculin A (an inhibitor of protein phosphatase 1 and 2A) but not by okadaic acid (a selective inhibitor of protein phosphatase 2A).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	53-62	AKT serine/threonine kinase 1	Homo sapiens	117-120
24977346-6	2014	Incubation with DETA NONOate (a stable NO donor) and 8-Br-cGMP (a cell membrane permeable analog of cGMP) attenuated Akt phosphorylation at Ser-473, which was prevented by Rp-8-Br-PET-cGMPS (a specific inhibitor of PKG) and calyculin A (an inhibitor of protein phosphatase 1 and 2A) but not by okadaic acid (a selective inhibitor of protein phosphatase 2A).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	53-62	protein kinase cGMP-dependent 1	Homo sapiens	215-218
24037816-4	2014	Ouabain-sensitive (86) Rb uptake was reduced by >35% in cultured NPE cells exposed to SNP (100 microM) or exogenously added cGMP (8-Br-cGMP) (100 microM) and the SFK inhibitor PP2 (10 microM) prevented the response.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	133-142	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	179-182
24037816-8	2014	Cells exposed to 8-Br-cGMP displayed SFK activation (phosphorylation) and inhibition of both ouabain-sensitive (86) Rb uptake and Na,K-ATPase activity that was prevented by PP2.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	17-26	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	173-176
24037816-10	2014	SNP and 8-Br-cGMP also increased phosphorylation of ERK1/2 and p38 MAPK and the response prevented by PP2.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	8-17	mitogen-activated protein kinase 3	Homo sapiens	52-58
24037816-10	2014	SNP and 8-Br-cGMP also increased phosphorylation of ERK1/2 and p38 MAPK and the response prevented by PP2.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	8-17	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	102-105
23832809-5	2013	After alpha-adrenergic stimulation, 8-Br-cGMP diminished similarly aortic tone and peripheral pressure in control, Trpc6(-/-), Trpc3(-/-), Trpc3(-/-)/6(-/-), and Trpc1(-/-)/3(-/-)/6(-/-) mice but not in sm-cGKI(-/-) mice.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	transient receptor potential cation channel, subfamily C, member 6	Mus musculus	115-120
23832809-5	2013	After alpha-adrenergic stimulation, 8-Br-cGMP diminished similarly aortic tone and peripheral pressure in control, Trpc6(-/-), Trpc3(-/-), Trpc3(-/-)/6(-/-), and Trpc1(-/-)/3(-/-)/6(-/-) mice but not in sm-cGKI(-/-) mice.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	127-132
23832809-5	2013	After alpha-adrenergic stimulation, 8-Br-cGMP diminished similarly aortic tone and peripheral pressure in control, Trpc6(-/-), Trpc3(-/-), Trpc3(-/-)/6(-/-), and Trpc1(-/-)/3(-/-)/6(-/-) mice but not in sm-cGKI(-/-) mice.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	transient receptor potential cation channel, subfamily C, member 3	Mus musculus	139-144
23832809-5	2013	After alpha-adrenergic stimulation, 8-Br-cGMP diminished similarly aortic tone and peripheral pressure in control, Trpc6(-/-), Trpc3(-/-), Trpc3(-/-)/6(-/-), and Trpc1(-/-)/3(-/-)/6(-/-) mice but not in sm-cGKI(-/-) mice.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	transient receptor potential cation channel, subfamily C, member 1	Mus musculus	162-167
23832809-5	2013	After alpha-adrenergic stimulation, 8-Br-cGMP diminished similarly aortic tone and peripheral pressure in control, Trpc6(-/-), Trpc3(-/-), Trpc3(-/-)/6(-/-), and Trpc1(-/-)/3(-/-)/6(-/-) mice but not in sm-cGKI(-/-) mice.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	protein kinase, cGMP-dependent, type I	Mus musculus	206-210
23832809-10	2013	Stimulated Ca(2+) levels were lowered by 8-Br-cGMP in Ctr but not in Trpc6(-/-) ECs.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	41-50	calcitonin receptor	Mus musculus	54-57
23352981-8	2013	8-Bromoguanosine-3",5"-cyclomo-nophosphate (8-Br-cGMP), a membrane permeable cGMP analog, mimicked the effect of CNP but not cANF (a specific NPR-C agonist).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	44-53	natriuretic peptide type C	Mus musculus	113-116
23665321-7	2013	Furthermore, incubation with the cGMP analogue 8-Br-cGMP prevented IL-1beta-induced VSMCs proliferation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	47-56	interleukin 1 beta	Homo sapiens	67-75
23545413-3	2013	Activation of cGKII by 8-Br-cGMP enhances the surface expression of GluA1, whereas its inhibition or suppression effectively diminished the expression of this protein at the cell surface.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	23-32	protein kinase cGMP-dependent 2	Homo sapiens	14-19
23545413-3	2013	Activation of cGKII by 8-Br-cGMP enhances the surface expression of GluA1, whereas its inhibition or suppression effectively diminished the expression of this protein at the cell surface.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	23-32	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	68-73
23545413-5	2013	GluA1 is mainly incorporated into calcium permeable AMPARs as exposure to 8-Br-cGMP or NMDA activation enhanced AMPA-elicited calcium responses that are sensitive to NASPM inhibition.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	74-83	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	0-5
23545413-5	2013	GluA1 is mainly incorporated into calcium permeable AMPARs as exposure to 8-Br-cGMP or NMDA activation enhanced AMPA-elicited calcium responses that are sensitive to NASPM inhibition.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	74-83	glutamate ionotropic receptor AMPA type subunit 1	Homo sapiens	52-58
23268358-10	2013	Moreover, the inhibitory effect of heparin on Ang II-induced vasoconstriction was reversed by Rp-cAMPS (cAMP-dependent PKA inhibitor), blunted by ODQ (soluble guanylate cyclase inhibitor), and mimicked by a cell-permeable cGMP analogue, 8-Br-cGMP, but not by a cAMP analogue.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	237-246	angiotensinogen (serpin peptidase inhibitor, clade A, member 8)	Mus musculus	46-52
21624369-6	2011	8-Br-cGMP also enhanced the ACTH action in both FW and SW eel preparations, suggesting that the NP actions were mediated by the guanylyl cyclase-coupled NP receptors (GC-A and B) that were localized in the eel interrenal.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	pro-opiomelanocortin	Equus caballus	28-32
23054060-12	2012	When RGS proteins were inhibited by CCG-63802 in the presence of BK and 8-Br-cGMP, cells started to depolarize again.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	72-81	paired like homeodomain 2	Homo sapiens	5-8
22737133-5	2012	Cx43 expression significantly increased after 270 min treatment with 8Br-cAMP, 8Br-cGMP, BAY or DADS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	79-87	gap junction protein, alpha 1	Rattus norvegicus	0-4
22737133-6	2012	Inhibition of PKA, PKG or PKC reversed 8Br-cAMP-stimulated increases in Cx43 expression, whereas only PKG or PKC inhibition reversed 8Br-cGMP- and BAY-stimulated increases in total Cx43.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	133-141	gap junction protein, alpha 1	Rattus norvegicus	181-185
22498562-10	2012	H(2)O(2) enhanced the activity of PKG I and relaxations of porcine coronary arteries to the nitric oxide donor and 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	115-124	protein kinase cGMP-dependent 1	Rattus norvegicus	34-39
22347188-6	2012	In comparison, 8Br-cGMP increased phosphorylation at VASP(Ser239) and VASP(Ser157) which were not affected by selective PDE inhibitors.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	15-23	vasodilator stimulated phosphoprotein	Homo sapiens	53-57
22347188-6	2012	In comparison, 8Br-cGMP increased phosphorylation at VASP(Ser239) and VASP(Ser157) which were not affected by selective PDE inhibitors.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	15-23	vasodilator stimulated phosphoprotein	Homo sapiens	70-74
22020732-9	2012	A suppressed phosphorylation of MYPT1 at Thr853 was caused by 8-Br-cGMP in large but not small arteries, which was inhibited by Rp-8-Br-PET-cGMPS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	62-71	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	32-37
22314978-5	2011	Fluorescence activated cell sorter (FACS) analysis was used to establish that 8-Br-cGMP, a PKG activator, caused carboxy terminal deletion on NOS, a sign of degradation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	78-87	protein kinase cGMP-dependent 1	Homo sapiens	91-94
22314978-7	2011	PKG activator 8-Br-cGMP, at 20 nM, 200 nM, and 2 muM, decreased nitric oxide production in a dose dependent manner (p<0.05 in all cases).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	protein kinase cGMP-dependent 1	Homo sapiens	0-3
22314978-9	2011	8-Br-cGMP (100 nM) abrogated the elevation in NO production produced by the PKG inhibitors.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	protein kinase cGMP-dependent 1	Homo sapiens	76-79
21624369-6	2011	8-Br-cGMP also enhanced the ACTH action in both FW and SW eel preparations, suggesting that the NP actions were mediated by the guanylyl cyclase-coupled NP receptors (GC-A and B) that were localized in the eel interrenal.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	grancalcin	Equus caballus	167-177
20698857-7	2010	The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	fibroblast growth factor 9	Homo sapiens	19-22
20978093-10	2011	8-Br-cGMP reduced stimulated [Ca2(+)](i) levels and glucagon release rates of CTR islets at 0.5 mmol/l glucose, but was without effect on [Ca2(+)](i) or hormone release in cGKI-deficient islets.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	protein kinase, cGMP-dependent, type I	Mus musculus	172-176
20698857-7	2010	The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	phosphodiesterase 5A	Homo sapiens	34-38
20698857-7	2010	The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	fibroblast growth factor 9	Homo sapiens	70-73
20698857-7	2010	The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	phosphodiesterase 5A	Homo sapiens	146-150
20698857-7	2010	The ligand for the GAF domains of PDE5, 8-Br-cGMP, elicited a 20-fold GAF-dependent activation and moreover revealed a time-dependent increase in PDE5 activity that occurred independently of a GAF ligand.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	fibroblast growth factor 9	Homo sapiens	70-73
20652958-4	2010	We also used fluorescence activated cell sorter analysis (FACS) to determine molecular and phosphorylation changes caused by PKG activation with 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	145-154	protein kinase cGMP-dependent 1	Homo sapiens	125-128
20855434-3	2010	Focal application of a PKG activator, 8-bromoguanosine-3",5"-cyclomonophosphate (8-Br-cGMP), to voltage-clamped XII motoneurones decreased inspiratory drive currents.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	81-90	protein kinase cGMP-dependent 1	Rattus norvegicus	23-26
20855434-6	2010	Application of 8-Br-cGMP with PKGI had no further effect on spontaneous or evoked currents, confirming that the observed effects were induced by PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	15-24	protein kinase cGMP-dependent 1	Rattus norvegicus	30-34
20855434-6	2010	Application of 8-Br-cGMP with PKGI had no further effect on spontaneous or evoked currents, confirming that the observed effects were induced by PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	15-24	protein kinase cGMP-dependent 1	Rattus norvegicus	30-33
20652958-5	2010	The PKG activator, 8-Br-cGMP (100 muM) produced a shift in the basal NO production curve downward.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	19-28	protein kinase cGMP-dependent 1	Homo sapiens	4-7
20652958-5	2010	The PKG activator, 8-Br-cGMP (100 muM) produced a shift in the basal NO production curve downward.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	19-28	latexin	Homo sapiens	34-37
20652958-9	2010	FACS analysis revealed that 5 muM 8-Br-cGMP in <5 min caused an increase in N-terminal labeling of NOS and a decrease in both C-terminal and serine 1177 labeling of NOS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	34-43	latexin	Homo sapiens	30-33
21117404-6	2010	PKG also decreased stimulated NO production: acetylcholine produced raw fluorescence of 59999 +/- 702 and in the presence of 1 mM 8-Br-cGMP the value was 20645 +/- 292 (p < 0.0001) while carbachol produced raw fluorescence of 60600 +/- 890 and in the presence of 1 mM 8-Br-cGMP was 30442 +/- 2000 (p < 0.01).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	130-139	protein kinase cGMP-dependent 1	Homo sapiens	0-3
20652958-10	2010	8-Br-cGMP appeared to increase PKG 1alpha and to decrease PKG 1beta labeling.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	protein kinase cGMP-dependent 1	Homo sapiens	31-34
20652958-10	2010	8-Br-cGMP appeared to increase PKG 1alpha and to decrease PKG 1beta labeling.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	protein kinase cGMP-dependent 1	Homo sapiens	58-61
20661711-3	2010	We analyzed the influence of ANG II on vascular contractions in the presence of sodium nitroprusside or 8Br-cGMP and after ischemia/reperfusion using classical pharmacometric methods.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	104-112	angiotensinogen	Rattus norvegicus	29-35
20661711-4	2010	Vascular contractions induced by ANG II were decreased by sodium nitroprusside and 8BrcGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	83-90	angiotensinogen	Rattus norvegicus	33-39
21117404-4	2010	We found a dose-response relationship between 8-Br-cGMP (0.02 - 2 microM), a stimulator of PKG activity, and inhibition of basal NO production.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	46-55	protein kinase cGMP-dependent 1	Homo sapiens	91-94
21117404-5	2010	The time-course of the effect of 2 microM 8-Br-cGMP on NO production exhibited a parallel shift downwards in the presence of PKG receptor inhibitor, 100 ng/ml DT-2, indicating that 8-Br-cGMP acts through PKG to inhibit NOS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	42-51	protein kinase cGMP-dependent 1	Homo sapiens	125-128
21117404-6	2010	PKG also decreased stimulated NO production: acetylcholine produced raw fluorescence of 59999 +/- 702 and in the presence of 1 mM 8-Br-cGMP the value was 20645 +/- 292 (p < 0.0001) while carbachol produced raw fluorescence of 60600 +/- 890 and in the presence of 1 mM 8-Br-cGMP was 30442 +/- 2000 (p < 0.01).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	271-280	protein kinase cGMP-dependent 1	Homo sapiens	0-3
21117404-5	2010	The time-course of the effect of 2 microM 8-Br-cGMP on NO production exhibited a parallel shift downwards in the presence of PKG receptor inhibitor, 100 ng/ml DT-2, indicating that 8-Br-cGMP acts through PKG to inhibit NOS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	42-51	protein kinase cGMP-dependent 1	Homo sapiens	204-207
21117404-5	2010	The time-course of the effect of 2 microM 8-Br-cGMP on NO production exhibited a parallel shift downwards in the presence of PKG receptor inhibitor, 100 ng/ml DT-2, indicating that 8-Br-cGMP acts through PKG to inhibit NOS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	181-190	protein kinase cGMP-dependent 1	Homo sapiens	125-128
21117404-5	2010	The time-course of the effect of 2 microM 8-Br-cGMP on NO production exhibited a parallel shift downwards in the presence of PKG receptor inhibitor, 100 ng/ml DT-2, indicating that 8-Br-cGMP acts through PKG to inhibit NOS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	181-190	protein kinase cGMP-dependent 1	Homo sapiens	204-207
21117404-9	2010	Both basal and stimulated NO production is regulated by the downstream activation of PKG by NO-induced 8-Br-cGMP production in endothelial cells.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	103-112	protein kinase cGMP-dependent 1	Homo sapiens	85-88
20176853-7	2010	The cGMP analogues and selective PKG activators 8Br-cGMP and 8pCPT-cGMP also induced airway relaxation and decreased the frequency of the Ca(2+) oscillations.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	48-56	protein kinase cGMP-dependent 1	Homo sapiens	33-36
20351057-3	2010	Rats receiving intra-LA infusion of the NR2B selective antagonist Ifenprodil, the NOS inhibitor 7-Ni, or the PKG inhibitor Rp-8-Br-PET-cGMPS exhibited significant decreases in ERK activation and in the training-induced expression of all three IEGs in the LA and MGm/PIN while intra-LA infusion of the PKG activator 8-Br-cGMP had the opposite effect.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	315-324	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	40-44
20351057-3	2010	Rats receiving intra-LA infusion of the NR2B selective antagonist Ifenprodil, the NOS inhibitor 7-Ni, or the PKG inhibitor Rp-8-Br-PET-cGMPS exhibited significant decreases in ERK activation and in the training-induced expression of all three IEGs in the LA and MGm/PIN while intra-LA infusion of the PKG activator 8-Br-cGMP had the opposite effect.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	315-324	Eph receptor B1	Rattus norvegicus	176-179
19961855-9	2010	Both sites were functionally relevant, as 8Br-cGMP strongly suppressed current in wild-type TRPC6 channels, but not in those with phospho-silencing mutations (T70A, S322A or S322Q).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	42-50	transient receptor potential cation channel subfamily C member 6	Homo sapiens	92-97
19961855-10	2010	NFAT activation and increased protein synthesis stimulated by ATII or ET1 was blocked by 8Br-cGMP or SIL.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	89-97	endothelin 1	Homo sapiens	70-73
19793106-6	2010	The effects of the selective PDE5 inhibitor sildenafil and subsequent protein kinase G-specific inhibitor Rp-8Br-cGMPs on MMP-2 production and RhoA activation were further exmamined.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	106-118	matrix metallopeptidase 2	Homo sapiens	122-127
19793106-6	2010	The effects of the selective PDE5 inhibitor sildenafil and subsequent protein kinase G-specific inhibitor Rp-8Br-cGMPs on MMP-2 production and RhoA activation were further exmamined.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	106-118	ras homolog family member A	Homo sapiens	143-147
19793106-16	2010	Furthermore, the protein kinase G-specific inhibitor Rp-8Br-cGMPs reversed the inhibitory effects of sildenafil on RhoA activation and MMP-2 production.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	53-65	ras homolog family member A	Homo sapiens	115-119
19793106-16	2010	Furthermore, the protein kinase G-specific inhibitor Rp-8Br-cGMPs reversed the inhibitory effects of sildenafil on RhoA activation and MMP-2 production.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	53-65	matrix metallopeptidase 2	Homo sapiens	135-140
19837876-12	2009	These data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	71-80	glucokinase	Rattus norvegicus	112-123
19896457-6	2009	In primary neurons from rats, treatment with the PKG-I activator 8-Br-cGMP induced a time-dependent phosphorylation of cofilin and significantly increased neurite outgrowth.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	65-74	protein kinase cGMP-dependent 1	Rattus norvegicus	49-54
19945442-7	2010	We report a striking effect following alteration of PKG activity in the brainstem such that slices treated with the PKG inhibitor KT5823 recovered fictive respiratory rhythm generation significantly faster than control slices and slices treated with a PKG activator (8-Br-cGMP).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	267-276	protein kinase cGMP-dependent 1	Homo sapiens	52-55
19945442-7	2010	We report a striking effect following alteration of PKG activity in the brainstem such that slices treated with the PKG inhibitor KT5823 recovered fictive respiratory rhythm generation significantly faster than control slices and slices treated with a PKG activator (8-Br-cGMP).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	267-276	protein kinase cGMP-dependent 1	Homo sapiens	116-119
19945442-7	2010	We report a striking effect following alteration of PKG activity in the brainstem such that slices treated with the PKG inhibitor KT5823 recovered fictive respiratory rhythm generation significantly faster than control slices and slices treated with a PKG activator (8-Br-cGMP).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	267-276	protein kinase cGMP-dependent 1	Homo sapiens	116-119
19860807-15	2010	8-Br-cGMP up-regulated TLR2, also demonstrating the importance of cGMP/PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	toll like receptor 2	Homo sapiens	23-27
19860807-15	2010	8-Br-cGMP up-regulated TLR2, also demonstrating the importance of cGMP/PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	protein kinase cGMP-dependent 1	Homo sapiens	71-74
19837876-7	2009	ANP and 8-Br-cGMP stimulated the phosphorylation of Akt and Foxo1a in INS-1E cells and islets, and LY294002 inhibited these responses.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	8-17	AKT serine/threonine kinase 1	Rattus norvegicus	52-55
19837876-7	2009	ANP and 8-Br-cGMP stimulated the phosphorylation of Akt and Foxo1a in INS-1E cells and islets, and LY294002 inhibited these responses.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	8-17	forkhead box O1	Rattus norvegicus	60-66
19837876-12	2009	These data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	71-80	AKT serine/threonine kinase 1	Rattus norvegicus	57-60
19837876-12	2009	These data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	71-80	forkhead box O1	Rattus norvegicus	173-179
19535511-6	2009	Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	cystic fibrosis transmembrane conductance regulator	Mus musculus	32-36
19837876-12	2009	These data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	71-80	cyclin D2	Rattus norvegicus	90-99
19837876-12	2009	These data support the conclusion that the activation of Akt by ANP or 8-Br-cGMP promotes cyclin D2, PDX-1, and glucokinase transcription by phosphorylating and restricting Foxo1a activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	71-80	pancreatic and duodenal homeobox 1	Rattus norvegicus	101-106
19535511-3	2009	Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	59-68	cystic fibrosis transmembrane conductance regulator	Mus musculus	164-168
19535511-3	2009	Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	59-68	cystic fibrosis transmembrane conductance regulator	Mus musculus	222-226
19535511-6	2009	Forskolin and 8-Br-cGMP induced CFTR phosphorylation and shifted CFTR proteins to the plasma membrane of duodenal epithelial cells, which were inhibited by wortmannin and LY294002.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	cystic fibrosis transmembrane conductance regulator	Mus musculus	65-69
19535511-3	2009	Forskolin and 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP) markedly stimulated duodenal mucosal HCO(3)(-) secretion and short-circuit current (I(sc)) in CFTR wild-type mice, which was significantly inhibited by CFTR(inh)-172, a highly potent and specific CFTR inhibitor.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	59-68	cystic fibrosis transmembrane conductance regulator	Mus musculus	222-226
19535511-7	2009	Forskolin and 8-Br-cGMP not only increased the activity of PI3K but also induced the phosphorylation of Akt, a signaling molecule downstream of PI3K, which were again inhibited by wortmannin and LY294002.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	thymoma viral proto-oncogene 1	Mus musculus	104-107
19428112-7	2009	Exogenous application of 8-Br-cGMP (3-30 microM) and purified thioredoxin (3-5 microM) partially mimicked BDNF effects in conferring 3-NP resistance to cortical cells.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	25-34	brain-derived neurotrophic factor	Rattus norvegicus	106-110
19570894-8	2009	Finally, inhibition of the cystic fibrosis transmembrane regulator (CFTR) Cl(-) conductance blocked depolarization of GI neurons to decreased glucose or AMPK activation, whereas decreased glucose, AMPK activation, and 8-Br-cGMP increased VMH CFTR phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	218-227	CF transmembrane conductance regulator	Homo sapiens	27-66
19570894-8	2009	Finally, inhibition of the cystic fibrosis transmembrane regulator (CFTR) Cl(-) conductance blocked depolarization of GI neurons to decreased glucose or AMPK activation, whereas decreased glucose, AMPK activation, and 8-Br-cGMP increased VMH CFTR phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	218-227	CF transmembrane conductance regulator	Homo sapiens	68-72
19531490-6	2009	GST-MYPT1 fragments induced a contraction of beta-escin-permeabilized ileum SM at constant pCa 6.3 (EC(50) = 2 microm), which was eliminated by Ala substitution of the fragment at Thr-696 or by ROCK inhibitors or 8Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	213-221	glutathione S-transferase kappa 1	Homo sapiens	0-3
19531490-6	2009	GST-MYPT1 fragments induced a contraction of beta-escin-permeabilized ileum SM at constant pCa 6.3 (EC(50) = 2 microm), which was eliminated by Ala substitution of the fragment at Thr-696 or by ROCK inhibitors or 8Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	213-221	protein phosphatase 1 regulatory subunit 12A	Homo sapiens	4-9
19570894-5	2009	Conversely, activation of sGC or the cell-permeable analog of cGMP, 8-bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP), enhanced the response of GI neurons to decreased glucose, suggesting that stimulation of NO-sGC-cGMP signaling by AMPK is required for glucose sensing in GI neurons.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	113-122	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	239-243
19570894-6	2009	Interestingly, the AMPK inhibitor compound C completely blocked the effect of sGC activation or 8-Br-cGMP, and 8-Br-cGMP increased VMH AMPKalpha2 phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	96-105	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	19-23
19570894-6	2009	Interestingly, the AMPK inhibitor compound C completely blocked the effect of sGC activation or 8-Br-cGMP, and 8-Br-cGMP increased VMH AMPKalpha2 phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	111-120	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	135-145
19656393-7	2009	Using immortalized, rat serotonergic raphe neurons (RN46A) previously shown to support 8-Br-cGMP stimulation of SERT surface trafficking, we document expression of PKGI, and to a lower extent, PKGII.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	87-96	solute carrier family 6 member 4	Rattus norvegicus	112-116
19656393-7	2009	Using immortalized, rat serotonergic raphe neurons (RN46A) previously shown to support 8-Br-cGMP stimulation of SERT surface trafficking, we document expression of PKGI, and to a lower extent, PKGII.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	87-96	protein kinase cGMP-dependent 1	Rattus norvegicus	164-168
19656393-10	2009	In keeping with the ability of the membrane permeant kinase inhibitor DT-2 to block 8-Br-cGMP stimulation of SERT, we found that DT-2 treatment eliminated cGMP-dependent kinase activity in PKGI-immunoreactive extracts resolved by liquid chromatography.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	84-93	solute carrier family 6 member 4	Rattus norvegicus	109-113
19656393-11	2009	Similarly, treatment of SERT-transfected HeLa cells with small interfering RNAs targeting endogenous PKGI eliminated 8-Br-cGMP-induced regulation of SERT activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	117-126	solute carrier family 6 member 4	Homo sapiens	24-28
19656393-11	2009	Similarly, treatment of SERT-transfected HeLa cells with small interfering RNAs targeting endogenous PKGI eliminated 8-Br-cGMP-induced regulation of SERT activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	117-126	protein kinase cGMP-dependent 1	Rattus norvegicus	101-105
19656393-11	2009	Similarly, treatment of SERT-transfected HeLa cells with small interfering RNAs targeting endogenous PKGI eliminated 8-Br-cGMP-induced regulation of SERT activity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	117-126	solute carrier family 6 member 4	Homo sapiens	149-153
19428112-6	2009	8-Br-cGMP is a cGMP analogue capable of activating PKG independent of NO.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	protein kinase cGMP-dependent 1	Homo sapiens	51-54
18586055-6	2008	8-Br-cGMP partially mimicked the effect of ANP on NOS in all tissues.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	natriuretic peptide A	Homo sapiens	43-46
19217919-7	2009	Its analogue, 8-Br-cGMP alone had no effect but significantly inhibited TNFalpha induced expression of PAI-1.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	tumor necrosis factor	Homo sapiens	72-80
19217919-7	2009	Its analogue, 8-Br-cGMP alone had no effect but significantly inhibited TNFalpha induced expression of PAI-1.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	serpin family E member 1	Homo sapiens	103-108
19614923-8	2009	Treatment with the cell-permeable cGMP analog 8-Br-cGMP increased both active and latent TGF-beta1.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	46-55	transforming growth factor beta 1	Homo sapiens	89-98
19614923-9	2009	However, TGF-beta1 activation induced by 8-Br-cGMP was not blocked by MAP kinase inhibitors.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	41-50	transforming growth factor beta 1	Homo sapiens	9-18
18786925-3	2008	Either SNAP (a NO donor) or 8-Br-cGMP (a cGMP analogue) could rescue these defects in iNOS-null macrophages, which indicated the participation of NO/cGMP in LPS-elicited Src expression and mobilization.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	28-37	nitric oxide synthase 2	Homo sapiens	86-90
18757523-7	2008	Phosphorylation of threonine 696 (ROCK substrate) and serine 695 (PKG substrate) of the regulatory myosin phosphatase targeting subunit MYPT1 of myosin light chain (MLC) phosphatase was stimulated to a lesser extent in CH than in control veins by endothelin-1 (ROCK stimulant) and 8-Br-cGMP (PKG stimulant), respectively.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	281-290	protein phosphatase 1 regulatory subunit 12A	Ovis aries	136-141
18786925-3	2008	Either SNAP (a NO donor) or 8-Br-cGMP (a cGMP analogue) could rescue these defects in iNOS-null macrophages, which indicated the participation of NO/cGMP in LPS-elicited Src expression and mobilization.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	28-37	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	170-173
18786925-4	2008	In addition, Src family kinase (SFK)-specific inhibitor, PP2, inhibited SNAP- and 8-Br-cGMP-evoked motility implicating the involvement of SFKs downstream of NO/cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	82-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	13-16
18786925-4	2008	In addition, Src family kinase (SFK)-specific inhibitor, PP2, inhibited SNAP- and 8-Br-cGMP-evoked motility implicating the involvement of SFKs downstream of NO/cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	82-91	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	32-35
18786925-4	2008	In addition, Src family kinase (SFK)-specific inhibitor, PP2, inhibited SNAP- and 8-Br-cGMP-evoked motility implicating the involvement of SFKs downstream of NO/cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	82-91	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	57-60
18757523-7	2008	Phosphorylation of threonine 696 (ROCK substrate) and serine 695 (PKG substrate) of the regulatory myosin phosphatase targeting subunit MYPT1 of myosin light chain (MLC) phosphatase was stimulated to a lesser extent in CH than in control veins by endothelin-1 (ROCK stimulant) and 8-Br-cGMP (PKG stimulant), respectively.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	281-290	EDN1	Ovis aries	247-259
17891157-11	2007	The relaxation caused by these dilators and by 8-Br-cGMP at their EC50 was attenuated by the PKG inhibitor by 51-66%.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	47-56	protein kinase cGMP-dependent 1	Homo sapiens	93-96
18832566-6	2008	As a test of this hypothesis, we next showed that rats given intra-LA infusion of the PKG inhibitor Rp-8-Br-PET-cGMPS or the PKG activator 8-Br-cGMP exhibit impaired or enhanced activation, respectively, of ERK/MAPK in the LA after fear conditioning.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	139-148	Eph receptor B1	Rattus norvegicus	207-210
17890448-5	2008	Thrombospondin-1-null murine platelets fail to aggregate in response to thrombin in the presence of exogenous NO or 8Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	116-124	thrombospondin 1	Mus musculus	0-16
18617565-4	2008	The inhibitory effects of SNAP and 8Br-cGMP on TRPC6 channel currents were strongly attenuated by the presence of inhibitors for guanylyl cyclase and PKG such as ODQ, KT5823 and DT3.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	35-43	transient receptor potential cation channel subfamily C member 6	Homo sapiens	47-52
18617565-4	2008	The inhibitory effects of SNAP and 8Br-cGMP on TRPC6 channel currents were strongly attenuated by the presence of inhibitors for guanylyl cyclase and PKG such as ODQ, KT5823 and DT3.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	35-43	protein kinase cGMP-dependent 1	Homo sapiens	150-153
18617565-5	2008	Alanine substitution for the PKG phosphorylation candidate site at T69 but not at other sites (T14A, S28A, T193A, S321A) of TRPC6 similarly attenuated the inhibitory effects of SNAP and 8Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	186-194	protein kinase cGMP-dependent 1	Homo sapiens	29-32
17553505-4	2008	One nanomole per litre of insulin in the presence of NO, or 50 micromol/L 8-Br-cGMP stimulated PP-2A activity by 46+/-6 and 247+/-23%, respectively (both P<0.05), and 8-Br-cGMP inhibited autonomous CaM kinase II activity by 67+/-9% (P<0.05) by a 10 nmol/L okadaic acid-sensitive pathway.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	74-83	protein phosphatase 2 phosphatase activator	Homo sapiens	95-100
17553505-4	2008	One nanomole per litre of insulin in the presence of NO, or 50 micromol/L 8-Br-cGMP stimulated PP-2A activity by 46+/-6 and 247+/-23%, respectively (both P<0.05), and 8-Br-cGMP inhibited autonomous CaM kinase II activity by 67+/-9% (P<0.05) by a 10 nmol/L okadaic acid-sensitive pathway.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	170-179	insulin	Homo sapiens	26-33
17891157-3	2007	EXPERIMENTAL APPROACH: Effects of a PKG inhibitor on the basal tension and responses induced by nitroglycerin, DETA NONOate, and 8-Br-cGMP in isolated porcine coronary veins were determined.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	129-138	protein kinase cGMP-dependent 1	Homo sapiens	36-39
17303654-6	2007	Moreover, 8-Br-cGMP, a protein kinase G (PKG) activator, mimicked P4"s action, whereas a PKG antagonist, DT-3, attenuated P4"s suppressive effect on ATP and apoptosis.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	10-19	protein kinase cGMP-dependent 1	Homo sapiens	23-39
17554080-4	2007	When activated with 8-Br-cAMP, 8-Br-cGMP, or alkaline depolarization, a CATSPER-dependent increase in intracellular Ca(2+) concentration starts in the principal piece, propagates through the midpiece, and reaches the head in a few seconds.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	31-40	cation channel, sperm associated 1	Mus musculus	72-79
17610578-3	2007	We have found that deletion of the alpha-synuclein gene blocks both the long-lasting enhancement of evoked and miniature transmitter release and the increase in the number of functional presynaptic boutons evoked through the NO donor, DEA/NO, and the cGMP analog, 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	264-273	synuclein alpha	Homo sapiens	35-50
17610578-4	2007	In agreement with these findings both DEA/NO and 8-Br-cGMP were capable of producing a long-lasting increase in number of clusters for alpha-synuclein through activation of soluble guanylyl cyclase, cGK and calcium/calmodulin-dependent protein kinase IIalpha.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	49-58	synuclein alpha	Homo sapiens	135-150
17610578-4	2007	In agreement with these findings both DEA/NO and 8-Br-cGMP were capable of producing a long-lasting increase in number of clusters for alpha-synuclein through activation of soluble guanylyl cyclase, cGK and calcium/calmodulin-dependent protein kinase IIalpha.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	49-58	protein kinase cGMP-dependent 1	Homo sapiens	199-202
17913834-2	2007	Using fura 2 ratiometry, we measured intracellular Ca(2+) concentration [Ca(2+)](i) to determine whether sodium nitroprusside (SNP), an NO donor, and 8-Br-cGMP affected SOC-TRPC4 via PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	150-159	transient receptor potential cation channel subfamily C member 4	Homo sapiens	173-178
17913834-4	2007	Addition of DT-3 (2.5 microM), a specific PKG-1alpha inhibitor, reversed the effects of 8-Br-cGMP on the SOC response.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	88-97	protein kinase cGMP-dependent 1	Homo sapiens	42-45
17913834-10	2007	Western blot analysis revealed that 8-Br-cGMP enhanced the phosphorylation of VASP at serine 239 (Ser239), a known PKG phosphorylation site, in HMC within 5 min.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	vasodilator stimulated phosphoprotein	Homo sapiens	78-82
17913834-10	2007	Western blot analysis revealed that 8-Br-cGMP enhanced the phosphorylation of VASP at serine 239 (Ser239), a known PKG phosphorylation site, in HMC within 5 min.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	protein kinase cGMP-dependent 1	Homo sapiens	115-118
17898384-10	2007	Inhibition of the cGMP-dependent kinase I alpha (cGK I alpha) using Rp-8-BrcGMPS (25 microM) blocked sildenafil-induced MKP-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	71-80	dual specificity phosphatase 1	Rattus norvegicus	120-125
17898384-11	2007	Either vanadate (12.5 microM), a phosphatase inhibitor, or Rp-8-BrcGMPS abolished the inhibitory effect of sildenafil on PDGF-stimulated phosphorylation of ERK1/2 and restored PDGF-induced cell proliferation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	62-71	mitogen activated protein kinase 3	Rattus norvegicus	156-162
17303654-6	2007	Moreover, 8-Br-cGMP, a protein kinase G (PKG) activator, mimicked P4"s action, whereas a PKG antagonist, DT-3, attenuated P4"s suppressive effect on ATP and apoptosis.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	10-19	protein kinase cGMP-dependent 1	Homo sapiens	41-44
16891621-7	2006	It is blocked by the soluble guanylate cyclase (sGC) inhibitor ODQ and the PKG inhibitor KT5823, and mimicked by the cGMP analog 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	129-138	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	21-46
17085546-10	2007	Pretreatment with PKG or PKA inhibitor abrogated BGMP and BAMP inhibition of IP(3) release.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	49-53	protein kinase cGMP-dependent 1	Homo sapiens	18-21
17005263-7	2007	The second messenger was the cGMP since the analogous 125 microM 8-Br-cGMP mimicked ANF effects.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	65-74	natriuretic peptide A	Homo sapiens	84-87
17615954-9	2006	The inhibitory effect of CNP was mimicked by 8-Br-cGMP, a membrane permeable cGMP analogue, which suggests that CNP could inhibit pacemaker currents via NPR-B-particulate guanylate cyclase (pGC)-cGMP signal pathway.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	45-54	natriuretic peptide type C	Mus musculus	25-28
17615954-9	2006	The inhibitory effect of CNP was mimicked by 8-Br-cGMP, a membrane permeable cGMP analogue, which suggests that CNP could inhibit pacemaker currents via NPR-B-particulate guanylate cyclase (pGC)-cGMP signal pathway.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	45-54	natriuretic peptide type C	Mus musculus	112-115
17615954-9	2006	The inhibitory effect of CNP was mimicked by 8-Br-cGMP, a membrane permeable cGMP analogue, which suggests that CNP could inhibit pacemaker currents via NPR-B-particulate guanylate cyclase (pGC)-cGMP signal pathway.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	45-54	natriuretic peptide receptor 2	Mus musculus	153-158
17182910-8	2007	KT-5823, a specific inhibitor of cGMP-dependent protein kinase (PGK), prevented the inhibition of the Ca(2+) current by SNP and 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	128-137	phosphoglycerate kinase 1	Rattus norvegicus	64-67
17406063-6	2007	Treatment of cells with 8-BrcGMP (0.5 mM) decreased the expression of Gialpha-2 and Gialpha-3 by about 30-45%, which was restored towards control levels by KT5823, an inhibitor of protein kinase G. On the other hand, the levels of Gsalpha protein were not altered by this treatment.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	24-32	G protein subunit alpha i3	Homo sapiens	84-93
17406063-6	2007	Treatment of cells with 8-BrcGMP (0.5 mM) decreased the expression of Gialpha-2 and Gialpha-3 by about 30-45%, which was restored towards control levels by KT5823, an inhibitor of protein kinase G. On the other hand, the levels of Gsalpha protein were not altered by this treatment.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	24-32	GNAS complex locus	Homo sapiens	231-238
16891621-7	2006	It is blocked by the soluble guanylate cyclase (sGC) inhibitor ODQ and the PKG inhibitor KT5823, and mimicked by the cGMP analog 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	129-138	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	48-51
16269521-8	2006	Adenovirus-based overexpression of PKG significantly attenuated contraction of LX-2 by 25% in response to 8-BrcGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	106-114	protein kinase cGMP-dependent 1	Homo sapiens	35-38
16754782-1	2006	The cell-permeable cGMP analog 8-Br-cGMP, xanthine-based KMUP-1 and KMUP-3, and the phosphodiesterase 5 inhibitor zaprinast all inhibited TNF-alpha-induced increases of iNOS expression and NO levels and reversed TNF-alpha-induced decreases of sGCalpha1, sGCbeta1, and PKG expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	31-40	tumor necrosis factor	Rattus norvegicus	138-147
16754782-1	2006	The cell-permeable cGMP analog 8-Br-cGMP, xanthine-based KMUP-1 and KMUP-3, and the phosphodiesterase 5 inhibitor zaprinast all inhibited TNF-alpha-induced increases of iNOS expression and NO levels and reversed TNF-alpha-induced decreases of sGCalpha1, sGCbeta1, and PKG expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	31-40	nitric oxide synthase 2	Rattus norvegicus	169-173
16446362-6	2006	In Chinese hamster ovary cells stably expressing PKGIalpha or PKGIbeta, 8-Br-cGMP activation suppressed [Ca2+]i by thrombin receptor activation peptide (TRAP) by 98 +/- 1 versus 42 +/- 5%, respectively (p <0.002).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	72-81	TRAP	Homo sapiens	153-157
16446362-9	2006	8-Br-cGMP significantly inhibited TRAP-induced [Ca2+]i in Co403, causing a 4-fold increase in the EC50 for [Ca2+]i.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	TRAP	Homo sapiens	34-38
16731781-11	2006	The stimulatory effect of ANP on acrosome reaction could be mimicked by the permeable cGMP analog, 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	99-108	natriuretic peptides A	Sus scrofa	26-29
16461919-5	2006	Ca2+ desensitization of contractile force by 8-Br-cGMP was attenuated by 50% in telokin KO intestinal smooth muscle.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	45-54	myosin, light polypeptide kinase	Mus musculus	80-87
16461919-6	2006	The rate of force relaxation reflecting MLCP activity, in the presence of 50 microM 8-Br-cGMP, was also significantly slowed in telokin KO vs. WT ileum and was rescued by recombinant telokin.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	84-93	myosin, light polypeptide kinase	Mus musculus	128-135
16461919-6	2006	The rate of force relaxation reflecting MLCP activity, in the presence of 50 microM 8-Br-cGMP, was also significantly slowed in telokin KO vs. WT ileum and was rescued by recombinant telokin.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	84-93	myosin, light polypeptide kinase	Mus musculus	183-190
16091733-2	2005	Here, we found that treatments with the cell-permeant analog 8-Br-cGMP and the soluble guanylate cyclase activator BAY41-2272, and Rho kinase (ROK) inhibition by Y27632 or a dominant negative form of ROK lead to PAR-1-mediated invasion through differential Rac1 and Cdc42 signaling.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	61-70	coagulation factor II thrombin receptor	Homo sapiens	212-217
16600513-9	2006	Furthermore, incubation of retinal cultures in the C-type natriuretic peptide-containing medium elevated cGMP immunoreactivity in the GABAergic amacrine cells, and the C-type natriuretic peptide effect on the glutamate current was mimicked by application of 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	258-267	natriuretic peptide C	Rattus norvegicus	51-77
16600513-9	2006	Furthermore, incubation of retinal cultures in the C-type natriuretic peptide-containing medium elevated cGMP immunoreactivity in the GABAergic amacrine cells, and the C-type natriuretic peptide effect on the glutamate current was mimicked by application of 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	258-267	natriuretic peptide C	Rattus norvegicus	168-194
16091733-2	2005	Here, we found that treatments with the cell-permeant analog 8-Br-cGMP and the soluble guanylate cyclase activator BAY41-2272, and Rho kinase (ROK) inhibition by Y27632 or a dominant negative form of ROK lead to PAR-1-mediated invasion through differential Rac1 and Cdc42 signaling.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	61-70	Rac family small GTPase 1	Homo sapiens	257-261
16091733-2	2005	Here, we found that treatments with the cell-permeant analog 8-Br-cGMP and the soluble guanylate cyclase activator BAY41-2272, and Rho kinase (ROK) inhibition by Y27632 or a dominant negative form of ROK lead to PAR-1-mediated invasion through differential Rac1 and Cdc42 signaling.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	61-70	cell division cycle 42	Homo sapiens	266-271
16167338-13	2005	To determinate the pathways that may mediate prolidase induction by NO, we first used 8-Br-cGMP, a cGMP agonist, and found that 8-Br-cGMP strongly and rapidly stimulated prolidase activity accompanied by increased phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	86-95	peptidase D	Homo sapiens	45-54
16167338-13	2005	To determinate the pathways that may mediate prolidase induction by NO, we first used 8-Br-cGMP, a cGMP agonist, and found that 8-Br-cGMP strongly and rapidly stimulated prolidase activity accompanied by increased phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	86-95	peptidase D	Homo sapiens	170-179
16167338-13	2005	To determinate the pathways that may mediate prolidase induction by NO, we first used 8-Br-cGMP, a cGMP agonist, and found that 8-Br-cGMP strongly and rapidly stimulated prolidase activity accompanied by increased phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	128-137	peptidase D	Homo sapiens	45-54
16167338-13	2005	To determinate the pathways that may mediate prolidase induction by NO, we first used 8-Br-cGMP, a cGMP agonist, and found that 8-Br-cGMP strongly and rapidly stimulated prolidase activity accompanied by increased phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	128-137	peptidase D	Homo sapiens	170-179
15870202-7	2005	Similarly, GLUT-4 translocation was significantly reduced in NTG (74 +/- 7%) and 8-Br-cGMP (120 +/- 11%), compared with control (165 +/- 17%).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	81-90	solute carrier family 2 member 4	Canis lupus familiaris	11-17
16272800-7	2005	An nitric oxide donor (NO) sodium nitropusside or a cGMP analog 8-br-cGMP caused moderate but significant decreases in both activity and mRNA expression of 11beta-HSD2.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	64-73	hydroxysteroid 11-beta dehydrogenase 2	Homo sapiens	156-167
16263110-7	2005	The effect induced by CNP was mimicked by 8-Br-cGMP but not by c-ANP-(4-23) amide (selective agonist of the natriuretic peptide receptor C).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	42-51	natriuretic peptide C	Rattus norvegicus	22-25
16151435-6	2005	Like KMUP-1, the membrane-permeable analogs of cGMP (8-Br-cGMP) and cAMP (8-Br-cAMP) enhanced the BKCa current.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	53-62	potassium calcium-activated channel subfamily M alpha 1	Rattus norvegicus	98-102
16054495-5	2005	cGMP analog 8-Br-cGMP (10 microM to 1mM) mimicked the effects of ANP on GVBD, PB1, and CEI.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	12-21	polybromo 1	Homo sapiens	78-81
16113690-9	2005	Moreover, sustained ERK phosphorylation was observed in the 8-Br-cGMP-treated PC12h cells.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	60-69	Eph receptor B1	Rattus norvegicus	20-23
15123611-10	2004	In PKC-sensitized preparations, CPI-17 phosphorylation decreased in response to 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	80-89	protein phosphatase 1, regulatory inhibitor subunit 14A	Mus musculus	32-38
15642775-4	2005	In Ca(2+)-loaded neurons, Ang II-induced decreases in [Ca(2+)]i were attenuated by phospholipase C inhibition (U73122) or nitric oxide (NO) synthase inhibition (L-NMMA) and were mimicked by the cGMP analogue 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	208-217	angiogenin	Homo sapiens	26-29
15530883-8	2004	Furthermore, NO donors and 8-Br-cGMP could also reverse the increased permeability of the monolayers induced by IL-1beta, IFN-gamma, and LPS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	27-36	interleukin 1 beta	Homo sapiens	112-120
15530883-8	2004	Furthermore, NO donors and 8-Br-cGMP could also reverse the increased permeability of the monolayers induced by IL-1beta, IFN-gamma, and LPS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	27-36	interferon gamma	Homo sapiens	122-131
15576431-5	2005	Treatment of primary cultures with adenovirus expressing PKG-1alpha mimicked NO-induced inhibition of insulin-elicited hydrogen peroxide elevation and cell motility, whereas treatment with the pharmacological PKG inhibitor Rp-8-bromo-3",5"-cyclic monophosphorothioate (Rp-8-Br-cGMPS) rescued the stimulatory effects of insulin that were suppressed by NO donor.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	272-282	protein kinase cGMP-dependent 1	Homo sapiens	57-60
15576431-5	2005	Treatment of primary cultures with adenovirus expressing PKG-1alpha mimicked NO-induced inhibition of insulin-elicited hydrogen peroxide elevation and cell motility, whereas treatment with the pharmacological PKG inhibitor Rp-8-bromo-3",5"-cyclic monophosphorothioate (Rp-8-Br-cGMPS) rescued the stimulatory effects of insulin that were suppressed by NO donor.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	272-282	insulin	Homo sapiens	102-109
15351713-7	2004	However, pre-treatment of PMN with NO donors or 8-Br-cGMP decreased their adhesion to recombinant E-selectin and ICAM-1, suggesting an effect of NO on PMN.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	48-57	selectin E	Homo sapiens	98-108
15351713-7	2004	However, pre-treatment of PMN with NO donors or 8-Br-cGMP decreased their adhesion to recombinant E-selectin and ICAM-1, suggesting an effect of NO on PMN.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	48-57	intercellular adhesion molecule 1	Homo sapiens	113-119
15212766-6	2004	GST-PDB affinity-precipitation experiments revealed that stimulation of HEK293 cells with either nitric oxide or 8-Br-cGMP resulted in a rapid and transient activation of Rac1 with similar kinetics to p38 MAPK phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	113-122	Rac family small GTPase 1	Homo sapiens	171-175
15212766-6	2004	GST-PDB affinity-precipitation experiments revealed that stimulation of HEK293 cells with either nitric oxide or 8-Br-cGMP resulted in a rapid and transient activation of Rac1 with similar kinetics to p38 MAPK phosphorylation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	113-122	mitogen-activated protein kinase 14	Homo sapiens	201-204
15212766-8	2004	The activation of both Rac1 and Pak1 by 8-Br-cGMP was completely abolished by transfection of the cells with G1alphaR-GFP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	Rac family small GTPase 1	Homo sapiens	23-27
15212766-8	2004	The activation of both Rac1 and Pak1 by 8-Br-cGMP was completely abolished by transfection of the cells with G1alphaR-GFP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	40-49	p21 (RAC1) activated kinase 1	Homo sapiens	32-36
15330854-4	2004	We show that a permeable cGMP analogue 8-Br-cGMP significantly reduces body size of the wild-type but not that of an egl-4 mutant, indicating that cGMP controls body size through EGL-4.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	39-48	cGMP-dependent protein kinase;cGMP-dependent protein kinase egl-4	Caenorhabditis elegans	179-184
14610087-5	2004	In intact ileum strips of wild type mice (cGKI+/+), 8-Br-cGMP inhibited the sustained phase of carbachol contractions by approximately 80%.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	52-61	protein kinase, cGMP-dependent, type I	Mus musculus	42-46
14656708-8	2004	In addition, 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP), an activator of PKG, induced ROS generation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	58-66	protein kinase cGMP-dependent 1	Homo sapiens	85-88
14656708-9	2004	The effect of 8-BrcGMP was reversed by either 5-HD or MPG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-22	N-methylpurine DNA glycosylase	Homo sapiens	54-57
12507727-7	2003	In rat cerebellar slices, activation of PKG with a nitric oxide (NO) donor, NOR3, or 8-Br-cGMP, increased phosphorylation of G-substrate, as demonstrated with a phosphorylation-specific antibody.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	85-94	protein phosphatase 1 regulatory subunit 17	Homo sapiens	125-136
15750850-6	2004	In alpha-toxin permeabilized femoral artery, 5 microM 8-Br-cGMP induced a two-fold increase in telokin phosphorylation and a maximal 30% relaxation of Ca2+-activated force compared to a 90% relaxation in phasic ileum muscle consistent with the relative amounts of telokin expressed in ileum, 27+/-4.6 microM SEM compared to 6+/-1.7 microM SEM, in femoral artery.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	54-63	myosin light chain kinase	Homo sapiens	95-102
15750850-6	2004	In alpha-toxin permeabilized femoral artery, 5 microM 8-Br-cGMP induced a two-fold increase in telokin phosphorylation and a maximal 30% relaxation of Ca2+-activated force compared to a 90% relaxation in phasic ileum muscle consistent with the relative amounts of telokin expressed in ileum, 27+/-4.6 microM SEM compared to 6+/-1.7 microM SEM, in femoral artery.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	54-63	myosin light chain kinase	Homo sapiens	264-271
14530262-7	2003	The NO donor 3-morpholinosydnonimine, HCl (SIN-1) and 8-bromo-guanosine 3",5"-cyclic monophosphate (8-Br-cGMP) functionally desensitized U46619-mediated calcium mobilization and inositol 1,4,5-trisphosphate generation by TP alpha whereas signaling by TP beta was unaffected by either agent.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	100-109	plasminogen activator, tissue type	Homo sapiens	221-229
14530262-7	2003	The NO donor 3-morpholinosydnonimine, HCl (SIN-1) and 8-bromo-guanosine 3",5"-cyclic monophosphate (8-Br-cGMP) functionally desensitized U46619-mediated calcium mobilization and inositol 1,4,5-trisphosphate generation by TP alpha whereas signaling by TP beta was unaffected by either agent.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	100-109	hydroxyacyl-CoA dehydrogenase trifunctional multienzyme complex subunit beta	Homo sapiens	251-258
12927919-6	2003	Preconditioning with both ANP and 8-Br-cGMP significantly reduced caspase-3-like activity and the number of triphosphate nick-end labelling-positive cells.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	34-43	caspase-3-like	Rattus norvegicus	66-80
12909191-10	2003	CNP and 8-br-cGMP caused a marked reduction of intracellular ornithine decarboxylase expression, as determined by Western blot analysis and immunohistochemical assay.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	8-17	ornithine decarboxylase 1	Rattus norvegicus	61-84
12909191-12	2003	Endothelin-1 also antagonized the CNP- and 8-br-cGMP-induced reduction of intracellular ornithine decarboxylase expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	43-52	endothelin 1	Rattus norvegicus	0-12
12909191-12	2003	Endothelin-1 also antagonized the CNP- and 8-br-cGMP-induced reduction of intracellular ornithine decarboxylase expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	43-52	ornithine decarboxylase 1	Rattus norvegicus	88-111
12858222-5	2003	We found that treatment of HDF with an NO donor, sodium nitroprusside (50 microM), enhanced the expression of MMP-1 and -2 by 153% and 243%, respectively, and treatment by 8-Br-cGMP enhanced MMP-1 and -2 expression by 137% and 254%, respectively.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	172-181	matrix metallopeptidase 1	Homo sapiens	191-203
14512447-4	2003	The concentration-response relationship for 8-Br-cGMP was shifted 2.5-fold to the right, indicating that abnormal sGC alone could not account for NT.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	44-53	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	114-117
12972168-7	2003	The 8-Br-cGMP or NO-donors enhanced GluR2/3 declustering, but did not induce it.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	4-13	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	36-41
12887778-4	2003	For the control study, the PKG specific inhibitor KT5823 was used to pretreat the endothelial cells before the administration of LPS or PKG activator 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	150-159	protein kinase cGMP-dependent 1	Homo sapiens	27-30
12205148-3	2002	L-LTP can be induced by either multiple-train tetanization, NO or 8-Br-cGMP paired with one-train tetanization, or the cAMP activator forskolin, and all three types of potentiation are accompanied by an increase in phospho-CREB immunofluorescence in the CA1 cell body area.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	66-75	liver transport protein	Mus musculus	2-5
12395288-5	2002	Incubation of rOCT1-expressing HEK293 cells for 10 min with 100 mM 8-Br-cGMP reduced initial ASP + uptake by maximally 78% with an IC50 value of 24 +/- 16 mM.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	67-76	solute carrier family 22 member 1	Rattus norvegicus	14-19
12205148-4	2002	Both the potentiation and the increase in phospho-CREB immunofluorescence induced by multiple-train tetanization or 8-Br-cGMP paired with one-train tetanization are reduced by prolonged perfusion with ryanodine, which blocks Ca(2+) release from ryanodine-sensitive Ca(2+) stores.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	116-125	cAMP responsive element binding protein 1	Mus musculus	50-54
11560940-8	2001	Sodium nitroprusside (10(-6) or 10(-5) m) and 8-Br-cGMP (10(-4) or 10(-3) m) increased TREK-1 currents in perforated whole cell and single channel recordings.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	46-55	potassium channel, subfamily K, member 2	Mus musculus	87-93
12072416-7	2002	In addition, treatment of 8-Br-cGMP significantly increased PFTK1 mRNA levels, and a specific inhibitor of cGMP production, ODQ, completely blocked TRH-induced expression of PFTK1 mRNA.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	26-35	cyclin-dependent kinase 14	Mus musculus	60-65
12072416-7	2002	In addition, treatment of 8-Br-cGMP significantly increased PFTK1 mRNA levels, and a specific inhibitor of cGMP production, ODQ, completely blocked TRH-induced expression of PFTK1 mRNA.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	26-35	cyclin-dependent kinase 14	Mus musculus	174-179
11947902-10	2002	Stabilisation of p53 was prevented by preincubation with the NO-donor GSNO or 8-br-cGMP, thus implying a downmodulatory effect of cGMP on pathways that upregulate the tumor suppressor p53.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	78-87	tumor protein p53	Homo sapiens	17-20
11947902-10	2002	Stabilisation of p53 was prevented by preincubation with the NO-donor GSNO or 8-br-cGMP, thus implying a downmodulatory effect of cGMP on pathways that upregulate the tumor suppressor p53.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	78-87	tumor protein p53	Homo sapiens	184-187
11723116-5	2002	The data show that in human smooth muscle cells, activation of PKG by 8-Br-cGMP led to phosphorylation and activation of PDE5.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	70-79	protein kinase cGMP-dependent 1	Homo sapiens	63-66
11723116-5	2002	The data show that in human smooth muscle cells, activation of PKG by 8-Br-cGMP led to phosphorylation and activation of PDE5.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	70-79	phosphodiesterase 5A	Homo sapiens	121-125
11723116-7	2002	Treatment of wild-type mouse aortic smooth muscle cells with 8-Br-cGMP also induced the phosphorylation of PDE5, whereas no phosphorylation was seen in smooth muscle cells isolated from mice in which the gene for PKG I had been disrupted.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	61-70	phosphodiesterase 5A, cGMP-specific	Mus musculus	107-111
11723116-7	2002	Treatment of wild-type mouse aortic smooth muscle cells with 8-Br-cGMP also induced the phosphorylation of PDE5, whereas no phosphorylation was seen in smooth muscle cells isolated from mice in which the gene for PKG I had been disrupted.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	61-70	protein kinase cGMP-dependent 1	Homo sapiens	213-216
11553613-7	2001	Moreover, 8-Br-cGMP increased KCC1 mRNA expression in a concentration- and time-dependent fashion.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	10-19	solute carrier family 12 member 4	Rattus norvegicus	30-34
11959985-6	2002	HCS and carboxylase mRNA levels in normal and MCD fibroblasts and HepG2 cells can be restored by the addition of the cGMP analogue, 8-Br-cGMP, and can be abolished by the addition of inhibitors of the soluble form of guanylate cyclase.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	132-141	holocarboxylase synthetase	Homo sapiens	0-3
11160411-7	2001	Finally, intracellular Rp-8-Br-cGMPS, a protein kinase G (PKG) inhibitor, blocked the hydroxylamine-induced membrane depolarization of cholinergic interneurons, whereas both okadaic acid and calyculin A, two protein phosphatase inhibitors, enhanced it, indicating that intracellular PKG and phosphatases oppositely regulate the sensitivity of striatal cholinergic interneurons to NO.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	26-36	protein kinase cGMP-dependent 1	Homo sapiens	40-56
11346659-1	2001	Forskolin and 8-bromoguanosine 3"-5"-cyclic monophosphate (8-Br-cGMP) induce phosphorylation of Ser-13 of telokin and relaxation of smooth muscle at constant calcium.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	59-68	myosin light chain kinase	Homo sapiens	106-113
11438734-5	2001	The cytostatic effects of GC-C agonists were associated with accumulation of intracellular cGMP, mimicked by the cell-permeant analog 8-Br-cGMP, and reproduced and potentiated by the cGMP-specific phosphodiesterase inhibitor zaprinast but not the inactive ST analog TJU 1-103.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	134-143	guanylate cyclase 2C	Homo sapiens	26-30
11379760-5	2001	Maximum stimulation was detected by treatment with 100 nM GSNO for 24 h. 8-Bromoguanosine 3",5"-cyclic monophosphate (8-Br-cGMP), an exogenous cyclic GMP analog, also upregulated tropoelastin synthesis.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	118-127	elastin	Gallus gallus	179-191
11313394-8	2001	In contrast, neutrophil spreading was accelerated when cGMP levels were elevated with 8-Br-cGMP, a direct activator of cGK.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	86-95	protein kinase cGMP-dependent 1	Homo sapiens	119-122
11160411-7	2001	Finally, intracellular Rp-8-Br-cGMPS, a protein kinase G (PKG) inhibitor, blocked the hydroxylamine-induced membrane depolarization of cholinergic interneurons, whereas both okadaic acid and calyculin A, two protein phosphatase inhibitors, enhanced it, indicating that intracellular PKG and phosphatases oppositely regulate the sensitivity of striatal cholinergic interneurons to NO.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	26-36	protein kinase cGMP-dependent 1	Homo sapiens	58-61
11160411-7	2001	Finally, intracellular Rp-8-Br-cGMPS, a protein kinase G (PKG) inhibitor, blocked the hydroxylamine-induced membrane depolarization of cholinergic interneurons, whereas both okadaic acid and calyculin A, two protein phosphatase inhibitors, enhanced it, indicating that intracellular PKG and phosphatases oppositely regulate the sensitivity of striatal cholinergic interneurons to NO.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	26-36	protein kinase cGMP-dependent 1	Homo sapiens	283-286
10694190-7	2000	Although 8-Br-cGMP (100 micromol/l) caused complete vasorelaxation of arterial rings pre-contracted with ET-1, it did not affect the MBG-induced vasoconstriction.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	9-18	endothelin 1	Homo sapiens	105-109
10952241-12	2000	8-Br-cGMP mimicked the effects of ANP on NF-kappaB and AP-1.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	natriuretic peptide A	Rattus norvegicus	34-37
10952241-12	2000	8-Br-cGMP mimicked the effects of ANP on NF-kappaB and AP-1.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-59
10801446-5	2000	In cells, CNrasGEF activates Ras in response to elevation of intracellular cAMP or cGMP, or treatment with their analogues 8-Br-cAMP or 8-Br-cGMP, independently of protein kinases A and G (PKA and PKG).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	136-145	Rap guanine nucleotide exchange factor 2	Homo sapiens	10-18
10982547-7	2000	SNAP and 8-Br-cGMP were both sufficient to lead to the site-specific phosphorylation (serine 32) and degradation of IkappaBalpha in isolated cardiac myocytes.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	9-18	NFKB inhibitor alpha	Homo sapiens	116-128
10783147-5	2000	The activity of the channel was inhibited by 8-Br-cGMP, a membrane-permeant activator of protein kinase G (PKG), in cell-attached membrane patches.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	45-54	protein kinase cGMP-dependent 1	Homo sapiens	89-105
10783147-5	2000	The activity of the channel was inhibited by 8-Br-cGMP, a membrane-permeant activator of protein kinase G (PKG), in cell-attached membrane patches.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	45-54	protein kinase cGMP-dependent 1	Homo sapiens	107-110
10771096-7	2000	The membrane-permeable homologue of cGMP, 8-Br-cGMP, also activated p38 MAPK (A(0.5) approximately 50 microM) but not Erk1 and Erk2.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	42-51	mitogen activated protein kinase 14	Rattus norvegicus	68-71
10771096-7	2000	The membrane-permeable homologue of cGMP, 8-Br-cGMP, also activated p38 MAPK (A(0.5) approximately 50 microM) but not Erk1 and Erk2.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	42-51	mitogen activated protein kinase 3	Rattus norvegicus	118-122
10771096-7	2000	The membrane-permeable homologue of cGMP, 8-Br-cGMP, also activated p38 MAPK (A(0.5) approximately 50 microM) but not Erk1 and Erk2.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	42-51	mitogen activated protein kinase 1	Rattus norvegicus	127-131
10644601-8	2000	The suppression of ANP secretion by CNP and 8-BrcGMP was abolished by a depletion of extracellular Ca(2+) in nonbeating atria.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	44-52	natriuretic peptides A	Oryctolagus cuniculus	19-22
10339545-6	1999	However, upon adenoviral reexpression of cGK II in primary cultures, ANP, SNP, and 8-Br-cGMP readily increased Ca2+ reabsorption.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	83-92	cGMP-dependent protein kinase 2	Oryctolagus cuniculus	41-47
10466117-9	1999	CONCLUSIONS: This study demonstrates that exogenous nitric oxide and 8-Br-cGMP could block adhesion dependent alterations in vascular permeability induced by CINC/gro, while adhesion-independent alterations in permeability induced by histamine could be blocked by exogenous NO but not 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	69-78	C-X-C motif chemokine ligand 1	Rattus norvegicus	163-166
9838202-6	1998	Administration of SNP and 8-Br cGMP to glial cells increased release of both opioids (471+/-58 vs. 1181+/-148 pg/mg protein methionine enkephalin before and after SNP 10-6 M).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	26-35	proenkephalin	Sus scrofa	135-145
10436402-10	1999	8-Br-cGMP caused stimulation of the Na-HCO(3) cotransporter activity although to a lesser degree than carbachol.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	solute carrier family 4 member 4	Homo sapiens	36-59
10200988-7	1999	8Br-cGMP also decreased PTEC sodium transport and Na,K-ATPase.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-8	Na pump alpha subunit	Drosophila melanogaster	50-61
10073597-6	1999	ANP (10 nM), BNP (10 nM), and URO (16 nM) depolarized these cells by 3 to 4 mV (n = 47, 7, and 16, respectively), an effect that could be mimicked by 0.1 mM 8-Br-cGMP (n = 15).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	157-166	natriuretic peptide A	Homo sapiens	0-3
10073597-6	1999	ANP (10 nM), BNP (10 nM), and URO (16 nM) depolarized these cells by 3 to 4 mV (n = 47, 7, and 16, respectively), an effect that could be mimicked by 0.1 mM 8-Br-cGMP (n = 15).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	157-166	natriuretic peptide B	Homo sapiens	13-16
10073597-9	1999	In the presence of CNP, 8-Br-cGMP further depolarized Vm significantly, by 1.6+/-0.3 mV (n = 5).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	24-33	natriuretic peptide C	Homo sapiens	19-22
9576960-6	1998	NMDA-induced Ras activation occurs through a cGMP-independent pathway as 1H-[1,2,4]oxadiazolo[4,3-alpha]quinoxalin-1-one (ODQ), a potent and selective inhibitor of guanylyl cyclase, has no effect on NMDA receptor-induced activation of Ras, and the cell-permeable cGMP analog, 8Br-cGMP, does not activate Ras.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	276-284	cyclin-dependent kinase inhibitor 1A (P21)	Mus musculus	13-16
9852090-5	1998	PKG-infected RPaSMC (multiplicity of infection = 200) with 8-Br-cGMP decreased serum-stimulated DNA synthesis by 85% and cell proliferation at day 5 by 74%.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	59-68	protein kinase cGMP-dependent 1	Homo sapiens	0-3
9852090-6	1998	The effect of 8-Br-cGMP on DNA synthesis in Ad.PKG-infected RPaSMC was blocked by KT5823 (PKG inhibitor), but not by KT5720 (cAMP-dependent protein kinase inhibitor).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	protein kinase cGMP-dependent 1	Homo sapiens	47-50
9852090-6	1998	The effect of 8-Br-cGMP on DNA synthesis in Ad.PKG-infected RPaSMC was blocked by KT5823 (PKG inhibitor), but not by KT5720 (cAMP-dependent protein kinase inhibitor).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	protein kinase cGMP-dependent 1	Homo sapiens	90-93
9887962-9	1998	Telokin, the independently expressed C-terminus of myosin light chain kinase, is extensively phosphorylated during forskolin- and 8-br-cGMP-induced relaxation in situ.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	130-139	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	0-7
9887962-9	1998	Telokin, the independently expressed C-terminus of myosin light chain kinase, is extensively phosphorylated during forskolin- and 8-br-cGMP-induced relaxation in situ.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	130-139	myosin light chain kinase, smooth muscle	Oryctolagus cuniculus	51-76
9876333-6	1998	The cyclic GMP analog, 8-Br-cGMP and the cyclic GMP specific phosphodiesterase inhibitor, zaprinast, both increased ACE.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	23-32	5'-nucleotidase, cytosolic II	Homo sapiens	11-14
9876333-6	1998	The cyclic GMP analog, 8-Br-cGMP and the cyclic GMP specific phosphodiesterase inhibitor, zaprinast, both increased ACE.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	23-32	angiotensin I converting enzyme	Homo sapiens	116-119
10375810-3	1998	RESULTS: Both 8-Br-cGMP 2.53 g.L-1 and L-arginine 100 g.L-1 increased plasma AVP level [from (2.6 +/- 0.3) to (6.6 +/- 0.4) ng.L-1, and from (3.2 +/- 0.5) to (5.8 +/- 1.4) ng.L-1, respectively; P < 0.01] 5 min after the icv injection; methylene blue (3.74 g.L-1) + L-arginine (100 g.L-1) did not change plasma AVP level.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	arginine vasopressin	Rattus norvegicus	77-80
10375810-3	1998	RESULTS: Both 8-Br-cGMP 2.53 g.L-1 and L-arginine 100 g.L-1 increased plasma AVP level [from (2.6 +/- 0.3) to (6.6 +/- 0.4) ng.L-1, and from (3.2 +/- 0.5) to (5.8 +/- 1.4) ng.L-1, respectively; P < 0.01] 5 min after the icv injection; methylene blue (3.74 g.L-1) + L-arginine (100 g.L-1) did not change plasma AVP level.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	14-23	arginine vasopressin	Rattus norvegicus	313-316
10454367-4	1998	First, brief perfusion with 8-Br-cGMP before weak tetanic stimulation produced long-lasting potentiation in the CA1 region of hippocampal slices, but more prolonged perfusion with 8-Br-cGMP before the tetanus did not produce long-lasting potentiation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	28-37	carbonic anhydrase 1	Homo sapiens	112-115
9852090-9	1998	In addition, 8-Br-cGMP and S-nitrosoglutathione induced apoptosis in serum-deprived RPaSMC infected with Ad.PKG, but not in uninfected cells or in cells infected with a control adenovirus.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	13-22	protein kinase cGMP-dependent 1	Homo sapiens	108-111
9812917-9	1998	The membrane-permeant cGMP analogue 8-Br-cGMP reduced Ang II-stimulated PAI-1 expression by 60%, and an inhibitor of soluble guanylyl cyclase (1H-[1,2,4]oxadiazolo[4, 3-a]quinoxalin-1-one) significantly impaired the inhibitory effects of S-nitroso-N-acetylpenicillamine on Ang II-stimulated PAI-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	angiotensinogen	Rattus norvegicus	54-60
9812917-9	1998	The membrane-permeant cGMP analogue 8-Br-cGMP reduced Ang II-stimulated PAI-1 expression by 60%, and an inhibitor of soluble guanylyl cyclase (1H-[1,2,4]oxadiazolo[4, 3-a]quinoxalin-1-one) significantly impaired the inhibitory effects of S-nitroso-N-acetylpenicillamine on Ang II-stimulated PAI-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	serpin family E member 1	Homo sapiens	72-77
9812917-9	1998	The membrane-permeant cGMP analogue 8-Br-cGMP reduced Ang II-stimulated PAI-1 expression by 60%, and an inhibitor of soluble guanylyl cyclase (1H-[1,2,4]oxadiazolo[4, 3-a]quinoxalin-1-one) significantly impaired the inhibitory effects of S-nitroso-N-acetylpenicillamine on Ang II-stimulated PAI-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	angiotensinogen	Rattus norvegicus	273-279
9812917-9	1998	The membrane-permeant cGMP analogue 8-Br-cGMP reduced Ang II-stimulated PAI-1 expression by 60%, and an inhibitor of soluble guanylyl cyclase (1H-[1,2,4]oxadiazolo[4, 3-a]quinoxalin-1-one) significantly impaired the inhibitory effects of S-nitroso-N-acetylpenicillamine on Ang II-stimulated PAI-1 expression.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	36-45	serpin family E member 1	Homo sapiens	291-296
9614141-8	1998	Given that both CO and NO activate guanylyl cyclase to produce cGMP and that a cGMP analog (8-Br-cGMP) showed a similar suppressive effect on the hypoxic induction of the VEGF enhancer, we speculate that the suppression of VEGF by these two gas molecules occurs via a cyclic GMP-mediated pathway.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	92-101	vascular endothelial growth factor A	Homo sapiens	171-175
9614141-8	1998	Given that both CO and NO activate guanylyl cyclase to produce cGMP and that a cGMP analog (8-Br-cGMP) showed a similar suppressive effect on the hypoxic induction of the VEGF enhancer, we speculate that the suppression of VEGF by these two gas molecules occurs via a cyclic GMP-mediated pathway.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	92-101	vascular endothelial growth factor A	Homo sapiens	223-227
9661135-8	1998	Both 8-bromo-guanosine 3",5"-cyclic monophosphate (8-br-cGMP) and dibutylyl adenosine 3",5"-cyclic monophate enhanced IL-1 beta-induced nitrite production.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	51-60	interleukin 1 beta	Rattus norvegicus	118-127
9486247-6	1998	Phosphorylation of the 93-kDa protein was augmented by pretreating cells with 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP) to activate PKG before addition of ANF.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	123-131	protein kinase cGMP-dependent 1	Homo sapiens	145-148
9421305-5	1997	The relaxant effects of YC-1 were reversed by 1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one (30 microM; ODQ), potentiated by zaprinast (10 microM) and antagonized by Rp-8-Br-cGMPS (100 microM).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	164-177	glutathione S-transferase alpha 1	Rattus norvegicus	24-28
9135548-12	1997	Furthermore, 8-Br-cGMP-mediated increase of intracellular cGMP caused the same pattern of cytokine inhibition as observed with SIN-1 and SNAP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	13-22	MAPK associated protein 1	Homo sapiens	127-132
9364042-5	1997	8-Br-cGMP, 1-methyl-3-isobutylxanthine (IBMX), and atrial natriuretic peptide (ANP) but not 8-Br-cAMP mimic the suppression of IRK+.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	0-9	potassium inwardly rectifying channel subfamily J member 12	Homo sapiens	127-130
9105879-5	1997	The shift by 8-Br-cAMP as well as by 8-Br-cGMP was completely reversed by Rp-8-Br-cGMPS, while a selective inhibitor of activation of cAMP-kinase, (Rp)-adenosine-3",5"-cyclic monophosphorothioate (Rp-cAMPS), was without effects on the shift produced by these two compounds.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	37-46	calmodulin 2, pseudogene 1	Rattus norvegicus	200-205
9098851-8	1997	Similarly, vasopressin-induced pial artery dilation was accompanied by elevated CSF cGMP and this dilation was attenuated in the presence of (Rp)-8-Br-cGMPs (13 +/- 1, 21 +/- 1, and 29 +/- 2 versus 5 +/- 1, 9 +/- 1, and 12 +/- 1% dilation for 40, 400, and 4000 pg/mL vasopressin before and after (Rp)-8-Br-cGMPs, respectively, n = 7).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	146-156	arginine vasopressin	Homo sapiens	11-22
9098851-8	1997	Similarly, vasopressin-induced pial artery dilation was accompanied by elevated CSF cGMP and this dilation was attenuated in the presence of (Rp)-8-Br-cGMPs (13 +/- 1, 21 +/- 1, and 29 +/- 2 versus 5 +/- 1, 9 +/- 1, and 12 +/- 1% dilation for 40, 400, and 4000 pg/mL vasopressin before and after (Rp)-8-Br-cGMPs, respectively, n = 7).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	146-156	arginine vasopressin	Homo sapiens	267-278
9098851-11	1997	Similarly, vasopressin-induced CSF methionine enkephalin and leucine enkephalin release was attenuated in the presence of (Rp)-8-Br-cGMPs.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	122-137	arginine vasopressin	Homo sapiens	11-22
9132156-5	1996	The results of our experiments with the use of 8-Br-cGMP and IBMX suggest that the modulating action of calmodulin was not mediated by the ROS phosphodiesterase activation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	47-56	calmodulin 1	Homo sapiens	104-114
8915590-3	1996	Intracellular injection of the PKG inhibitor peptide, PKGI, prevented the 8BrcGMP-mediated increase in the GABA response indicating that 8BrcGMP enhances GABAA receptor function via activation of PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	74-81	protein kinase cGMP-dependent 1	Homo sapiens	31-34
8915590-3	1996	Intracellular injection of the PKG inhibitor peptide, PKGI, prevented the 8BrcGMP-mediated increase in the GABA response indicating that 8BrcGMP enhances GABAA receptor function via activation of PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	74-81	protein kinase cGMP-dependent 1	Homo sapiens	54-57
8915590-3	1996	Intracellular injection of the PKG inhibitor peptide, PKGI, prevented the 8BrcGMP-mediated increase in the GABA response indicating that 8BrcGMP enhances GABAA receptor function via activation of PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	137-144	protein kinase cGMP-dependent 1	Homo sapiens	31-34
8915590-3	1996	Intracellular injection of the PKG inhibitor peptide, PKGI, prevented the 8BrcGMP-mediated increase in the GABA response indicating that 8BrcGMP enhances GABAA receptor function via activation of PKG.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	137-144	protein kinase cGMP-dependent 1	Homo sapiens	54-57
8862144-5	1996	The decline of the Ang II responses was suppressed by removal of the endothelium or by exposure of arteries with endothelium to either the NO synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (300 microM), or the cyclic GMP-dependent protein kinase inhibitor, Rp-8-bromoguanosine 3",5"-cyclic monophosphorothioate (30 microM).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	269-322	angiotensinogen	Rattus norvegicus	19-25
8763798-3	1996	We report that 8-Br-cGMP strongly down-regulates the odour sensitivity of the cells, with a K1/2 of 460 nM.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	15-24	keratin 1	Homo sapiens	92-106
8793114-6	1996	The calcium channel agonist Bay K, forskolin and phorbol esters increased secretogranin II mRNA whereas 8-Br-cGMP repressed the secretogranin II message.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	104-113	secretogranin II	Bos taurus	128-144
9363223-4	1996	Both 8-Br-cGMP and 8-Br-cAMP enhanced the expression of hCG in cultured cytotrophoblasts with the differentiation of cytotrophoblasts to syncytiotrophoblasts dose-dependently.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	5-14	hypertrichosis 2 (generalised, congenital)	Homo sapiens	56-59
8899823-7	1996	The glucagon secretion coupling cascade affected by ANP probably involves an increase in cGMP because 8-Br-cGMP (a membrane-permeable cGMP analogue) also decreased glucagon secretion.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	102-111	natriuretic peptide A	Rattus norvegicus	52-55
7611424-5	1995	In this study, CNP was found to increase CBF by 30 +/- 6.9%, and this effect was mimicked by the cGMP analogue, 8-bromoguanosine 3",5"-cyclic monophosphate (8-BrcGMP), but not by sodium nitroprusside.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	157-165	natriuretic peptide C	Homo sapiens	15-18
7543493-9	1995	Short circuit current (ISC), a measure of Cl- secretion, was increased to a similar extent by STa and by 8-Br-cGMP, a selective activator of cGK, except in distal colon and in monolayers of T84 human colon carcinoma cells in which cGK II was not detected.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	105-114	protein kinase cGMP-dependent 1	Homo sapiens	141-144
7473217-6	1995	Inhibition by calmodulin required calcium and gave as much as a 5-fold decrease in current for an [8-Br-cGMP] functionally comparable to the presumed physiological [cGMP].	8-bromoguanosino-3',5'-cyclic monophosphorothioate	99-108	calmodulin 1	Homo sapiens	14-24
7473217-13	1995	Furthermore, patches with high initial sensitivity to 8-Br-cGMP had small low-Ca2+ effects and large calmodulin effects, while the reverse was true for patches with low initial agonist sensitivity.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	54-63	calmodulin 1	Homo sapiens	101-111
7476938-3	1995	Intracellular application of the catalytic subunit of PK-A (PK-A(cat); 1.5 microM) via the patch pipette rapidly potentiated ICa(L) by 215 +/- 16%) (n = 4); subsequent addition of 1 mM 8Br-cGMP to the bath reduced the amplitude of ICa(L) towards the initial control values (123 +/- 29%).	8-bromoguanosino-3',5'-cyclic monophosphorothioate	185-193	catalase	Gallus gallus	19-22
7476938-7	1995	The results of the present study suggest that: (a) 8Br-cGMP can inhibit the basal or stimulated (by PK-A(cat)) ICa(L) in embryonic chick myocardial cells.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	51-59	catalase	Gallus gallus	100-109
7478932-1	1995	The effects of 8-bromoguanosine 3":5"-cyclic monophosphate (8Br-cGMP), a membrane-permeant activator of protein kinase G (PKG), were studied on rat and human connexin43 (Cx43), the most abundant gap junction protein in mammalian heart, which were exogenously expressed in SKHep1 cells.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	60-68	gap junction protein alpha 1	Homo sapiens	158-168
7478932-2	1995	Under dual whole-cell voltage-clamp conditions, 8Br-cGMP decreased gap junctional conductance (gj) in rat Cx43-transfected cells by 24.0 +/- 3.7% (mean +/- SEM, n = 5), whereas gj was not affected in human Cx43-transfected cells by the same treatment.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	48-56	gap junction protein, alpha 1	Rattus norvegicus	106-110
7478932-2	1995	Under dual whole-cell voltage-clamp conditions, 8Br-cGMP decreased gap junctional conductance (gj) in rat Cx43-transfected cells by 24.0 +/- 3.7% (mean +/- SEM, n = 5), whereas gj was not affected in human Cx43-transfected cells by the same treatment.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	48-56	gap junction protein alpha 1	Homo sapiens	206-210
7478932-7	1995	In the presence of 8Br-cGMP, the gammaj distribution shifted to the lower size in rat Cx43 but not in human Cx43 transfectants.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	19-27	gap junction protein, alpha 1	Rattus norvegicus	86-90
7478932-7	1995	In the presence of 8Br-cGMP, the gammaj distribution shifted to the lower size in rat Cx43 but not in human Cx43 transfectants.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	19-27	gap junction protein alpha 1	Homo sapiens	108-112
7478932-9	1995	However, the basal incorporation of [32P] into rat Cx43 was significantly altered by 8Br-cGMP, whereas this incorporation of [32P] into human Cx43 was not affected.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	85-93	gap junction protein, alpha 1	Rattus norvegicus	51-55
7478932-10	1995	We conclude that 8Br-cGMP modulates phosphorylation of rat Cx43 in SKHep1 cells, but not of human Cx43.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	17-25	gap junction protein, alpha 1	Rattus norvegicus	59-63
7473217-4	1995	Calmodulin shifted to the right the dose-response relation for activation of the channels by 8-Br-cGMP, but did not change the maximum current or the form of the relation.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	93-102	calmodulin 1	Homo sapiens	0-10
7473217-5	1995	Reversal of this effect by removal of calmodulin was accelerated by brief exposure to saturating [8-Br-cGMP].	8-bromoguanosino-3',5'-cyclic monophosphorothioate	98-107	calmodulin 1	Homo sapiens	38-48
7700014-3	1994	Nitroprusside, atriopeptin II and 8-Br-cGMP all increased renin release but the dose-response relationships were biphasic.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	34-43	renin	Rattus norvegicus	58-63
7852845-5	1995	Exogenous 8-BrcGMP and dbcGMP increased LPS-stimulated TNF-alpha synthesis but had no effect on KC TNF-alpha in the absence of LPS.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	10-18	tumor necrosis factor	Homo sapiens	55-64
1321624-5	1992	Additionally, 8-pCPT-cGMP did not activate the cGS-PDE or inhibit the cGI-PDE, whereas half-maximal inhibition of cGI-PDE occurred at 8 microM 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	143-152	phosphodiesterase 3A	Homo sapiens	114-121
7523213-8	1994	Immunohistochemistry showed a significant increase in P-selectin expression after 60 minutes of superfusion with L-NAME, which was attenuated by L-arginine, hSOD, and 8-br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	167-176	selectin P	Rattus norvegicus	54-64
7524476-7	1994	Heparin, 8-Br-cAMP or 8-Br-cGMP also suppressed c-myc, but this occurred later, after 24-48 h, and was also observed following arrest by metabolic block.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	22-31	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	48-53
8104781-5	1993	In addition, exposure of LHRH cells (GT1-7 cells) to increasing concentrations of a soluble analog of cGMP (8-Br-cGMP) enhanced LHRH release in a dose-dependent manner, indicating that LHRH neurons have the intrinsic ability to respond to the intracellular messenger elicited by NO, i.e., cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	108-117	gonadotropin releasing hormone 1	Mus musculus	25-29
8104781-5	1993	In addition, exposure of LHRH cells (GT1-7 cells) to increasing concentrations of a soluble analog of cGMP (8-Br-cGMP) enhanced LHRH release in a dose-dependent manner, indicating that LHRH neurons have the intrinsic ability to respond to the intracellular messenger elicited by NO, i.e., cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	108-117	gonadotropin releasing hormone 1	Mus musculus	128-132
8104781-5	1993	In addition, exposure of LHRH cells (GT1-7 cells) to increasing concentrations of a soluble analog of cGMP (8-Br-cGMP) enhanced LHRH release in a dose-dependent manner, indicating that LHRH neurons have the intrinsic ability to respond to the intracellular messenger elicited by NO, i.e., cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	108-117	gonadotropin releasing hormone 1	Mus musculus	128-132
1657955-6	1991	The filamentous staining pattern for G-kinase and vimentin was enhanced in the presence of 8-Br-cGMP.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	91-100	vimentin	Homo sapiens	50-58
1657955-9	1991	Phosphorylation of vimentin in the fMLP-stimulated neutrophil was observed in the presence or absence of exogenous cGMP, although in the presence of low concentrations of 8-Br-cGMP a more rapid phosphorylation of vimentin was observed that correlated with the enhanced co-localization of G-kinase and vimentin.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	171-180	vimentin	Homo sapiens	19-27
1657955-9	1991	Phosphorylation of vimentin in the fMLP-stimulated neutrophil was observed in the presence or absence of exogenous cGMP, although in the presence of low concentrations of 8-Br-cGMP a more rapid phosphorylation of vimentin was observed that correlated with the enhanced co-localization of G-kinase and vimentin.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	171-180	vimentin	Homo sapiens	213-221
1657955-9	1991	Phosphorylation of vimentin in the fMLP-stimulated neutrophil was observed in the presence or absence of exogenous cGMP, although in the presence of low concentrations of 8-Br-cGMP a more rapid phosphorylation of vimentin was observed that correlated with the enhanced co-localization of G-kinase and vimentin.	8-bromoguanosino-3',5'-cyclic monophosphorothioate	171-180	vimentin	Homo sapiens	213-221