PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
26252617-0	2015	Effects of rotigaptide (ZP123) on connexin43 remodeling in canine ventricular fibrillation.	rotigaptide	24-29	gap junction protein alpha 1	Canis lupus familiaris	34-44
26750458-2	2016	Rotigaptide increases gap junction conductance via connexin-43.	rotigaptide	0-11	gap junction protein alpha 1	Homo sapiens	51-62
32560352-0	2020	The Connexin 43 Regulator Rotigaptide Reduces Cytokine-Induced Cell Death in Human Islets.	rotigaptide	26-37	gap junction protein alpha 1	Homo sapiens	4-15
32560352-2	2020	Rotigaptide (RG, ZP123) is a peptide analog that increases intercellular conductance in cardiac muscle cells by the prevention of dephosphorylation and thereby uncoupling of Connexin-43 (Cx43), possibly via action on unidentified protein phosphatases.	rotigaptide	0-11	gap junction protein alpha 1	Homo sapiens	174-185
32560352-2	2020	Rotigaptide (RG, ZP123) is a peptide analog that increases intercellular conductance in cardiac muscle cells by the prevention of dephosphorylation and thereby uncoupling of Connexin-43 (Cx43), possibly via action on unidentified protein phosphatases.	rotigaptide	0-11	gap junction protein alpha 1	Homo sapiens	187-191
32560352-2	2020	Rotigaptide (RG, ZP123) is a peptide analog that increases intercellular conductance in cardiac muscle cells by the prevention of dephosphorylation and thereby uncoupling of Connexin-43 (Cx43), possibly via action on unidentified protein phosphatases.	rotigaptide	17-22	gap junction protein alpha 1	Homo sapiens	174-185
32560352-2	2020	Rotigaptide (RG, ZP123) is a peptide analog that increases intercellular conductance in cardiac muscle cells by the prevention of dephosphorylation and thereby uncoupling of Connexin-43 (Cx43), possibly via action on unidentified protein phosphatases.	rotigaptide	17-22	gap junction protein alpha 1	Homo sapiens	187-191
26252617-1	2015	The present study investigated the effects of rotigaptide (ZP123) on the expression, distribution and phosphorylation of connexin43 (Cx43) in myocardial cell membranes in cardioversion of ventricular fibrillation (VF).	rotigaptide	46-57	gap junction protein alpha 1	Canis lupus familiaris	121-131
26252617-1	2015	The present study investigated the effects of rotigaptide (ZP123) on the expression, distribution and phosphorylation of connexin43 (Cx43) in myocardial cell membranes in cardioversion of ventricular fibrillation (VF).	rotigaptide	46-57	gap junction protein alpha 1	Canis lupus familiaris	133-137
23304014-14	2012	We conclude that ZP123 can reduce defibrillation-energy requirements by preventing connexin43 remodeling during prolonged ventricular fibrillation.	rotigaptide	17-22	gap junction protein alpha 1	Sus scrofa	83-93
21493965-5	2011	Rotigaptide partially reversed the loss of Cx43 but did not affect the increase in S368 phosphorylation, nor did it reverse Cx43 lateralization.	rotigaptide	0-11	gap junction protein alpha 1	Canis lupus familiaris	43-47
17982010-9	2008	However, connexin43 dephosphorylation in response to low-flow ischemia was significantly prevented by rotigaptide (15.9 +/- 7.0 vs. 0.3 +/- 6.4%, P < 0.001).	rotigaptide	102-113	gap junction alpha-1 protein	Cavia porcellus	9-19
20977841-1	2010	OBJECTIVE: To observe changes in connexin 43 (Cx43) after ventricular fibrillation (VF) and the effects of rotigaptide (ZP123) on Cx43.	rotigaptide	107-118	gap junction protein alpha 1	Sus scrofa	130-134
18789901-2	2008	Rotigaptide enhances communication via the connexin 43 gap junction subunit and may potentiate the vascular actions of EDHF.	rotigaptide	0-11	gap junction protein alpha 1	Homo sapiens	43-54
17845503-8	2007	At the cellular level, rotigaptide inhibits ischaemia-induced dephosphorylation of Ser297 and Ser368, which is considered important for the gating of connexin43 gap junction channels.	rotigaptide	23-34	gap junction protein alpha 1	Homo sapiens	150-160
16678851-0	2006	Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).	rotigaptide	132-143	gap junction protein, alpha 1	Rattus norvegicus	62-72
16678851-0	2006	Identification of ischemia-regulated phosphorylation sites in connexin43: A possible target for the antiarrhythmic peptide analogue rotigaptide (ZP123).	rotigaptide	145-150	gap junction protein, alpha 1	Rattus norvegicus	62-72
16678851-9	2006	Our results suggest that phosphorylation of Ser297 and Ser368 may be involved in functional gating of Cx43 during ischemia and may be possible downstream targets for rotigaptide signaling.	rotigaptide	166-177	gap junction protein, alpha 1	Rattus norvegicus	102-106
16415913-0	2006	The antiarrhythmic peptide rotigaptide (ZP123) increases gap junction intercellular communication in cardiac myocytes and HeLa cells expressing connexin 43.	rotigaptide	27-38	gap junction protein alpha 1	Homo sapiens	144-155
34529322-5	2022	In addition, following 3 compounds were identified as inhibitors for Spike/ACE2: Denopamine, bometolol, and rotigaptide.	rotigaptide	108-119	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	69-74
34529322-5	2022	In addition, following 3 compounds were identified as inhibitors for Spike/ACE2: Denopamine, bometolol, and rotigaptide.	rotigaptide	108-119	angiotensin converting enzyme 2	Homo sapiens	75-79
35533905-11	2022	Dye transfer assays confirmed impairment of gap-junction function; Cx43 gap-junction enhancer ZP123 decreased arrhythmia inducibility in ISO-treated Mog1-/- mice.	rotigaptide	94-99	gap junction protein, alpha 1	Mus musculus	67-71
35533905-11	2022	Dye transfer assays confirmed impairment of gap-junction function; Cx43 gap-junction enhancer ZP123 decreased arrhythmia inducibility in ISO-treated Mog1-/- mice.	rotigaptide	94-99	RAN guanine nucleotide release factor	Mus musculus	149-153
16415913-3	2006	The communication-modifying effect of rotigaptide was confined to cells expressing Cx43 since the peptide had no effect on dye transfer in HeLa cells expressing Cx32-GFP, Cx26-GFP or wild-type Cx26.	rotigaptide	38-49	gap junction protein alpha 1	Homo sapiens	83-87
16415913-4	2006	In contrast, HeLa cells expressing Cx43-GFP exposed to 50 nM rotigaptide for 5 h showed a 40% increase in gap junction mediated communication.	rotigaptide	61-72	gap junction protein alpha 1	Homo sapiens	35-39
16415913-5	2006	Rotigaptide (50 nM) increased intercellular dye transfer in myocytes and atrial HL-1 cells, where Cx43 is the dominant connexin.	rotigaptide	0-11	gap junction protein alpha 1	Homo sapiens	98-102
16613777-0	2006	The antiarrhythmic peptide rotigaptide (ZP123) increases connexin 43 protein expression in neonatal rat ventricular cardiomyocytes.	rotigaptide	27-38	gap junction protein, alpha 1	Rattus norvegicus	57-68
16613777-1	2006	Rotigaptide (formerly ZP123) is a novel antiarrhythmic peptide that prevents uncoupling of connexin 43 (Cx43)-mediated, gap junction communication during acute metabolic stress.	rotigaptide	0-11	gap junction protein, alpha 1	Rattus norvegicus	91-102
16613777-1	2006	Rotigaptide (formerly ZP123) is a novel antiarrhythmic peptide that prevents uncoupling of connexin 43 (Cx43)-mediated, gap junction communication during acute metabolic stress.	rotigaptide	0-11	gap junction protein, alpha 1	Rattus norvegicus	104-108
16613777-1	2006	Rotigaptide (formerly ZP123) is a novel antiarrhythmic peptide that prevents uncoupling of connexin 43 (Cx43)-mediated, gap junction communication during acute metabolic stress.	rotigaptide	22-27	gap junction protein, alpha 1	Rattus norvegicus	91-102
16613777-1	2006	Rotigaptide (formerly ZP123) is a novel antiarrhythmic peptide that prevents uncoupling of connexin 43 (Cx43)-mediated, gap junction communication during acute metabolic stress.	rotigaptide	22-27	gap junction protein, alpha 1	Rattus norvegicus	104-108
16613777-2	2006	Since rotigaptide"s long-term effects on Cx43 are unknown, we studied its effect on Cx43 protein levels at 24 h in neonatal ventricular myocytes.	rotigaptide	6-17	gap junction protein, alpha 1	Rattus norvegicus	84-88
16613777-3	2006	As determined by Western blot analysis, rotigaptide produced a dose-dependent increase in Cx43 protein expression that reached a maximum level at 100 nM.	rotigaptide	40-51	gap junction protein, alpha 1	Rattus norvegicus	90-94
16613777-4	2006	Furthermore, 100 nM rotigaptide markedly increased Cx43 immunoreactivity and Cx43-positive gap junctions as observed in immunocytochemical studies.	rotigaptide	20-31	gap junction protein, alpha 1	Rattus norvegicus	51-55
16613777-4	2006	Furthermore, 100 nM rotigaptide markedly increased Cx43 immunoreactivity and Cx43-positive gap junctions as observed in immunocytochemical studies.	rotigaptide	20-31	gap junction protein, alpha 1	Rattus norvegicus	77-81