PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25315826-1	2014	A wealth of evidence indicates that the activation of 5-HT1A and 5-HT2A receptors in the dorsal periaqueductal grey matter (dPAG) inhibits escape, a panic-related defensive behaviour.	dpag	124-128	5-hydroxytryptamine receptor 1A	Rattus norvegicus	54-66
26350338-6	2015	As with 5-HT, activation of GABAA or GABAB receptors, or cannabinoid type 1receptors as well as the tropomyosin-related kinase B receptors by brain-derived neurotrophic factor in the DPAG also inhibits escape expression.	dpag	183-187	brain derived neurotrophic factor	Homo sapiens	142-175
26350338-8	2015	On the other hand, facilitation of corticotrophin releasing factor- or cholecystokinin-mediated neurotransmission in the DPAG, via CRF1 and CCK2 receptors, respectively, causes panicogenic-like effects with implications for the pathogenesis of PD.	dpag	121-125	corticotropin releasing hormone receptor 1	Homo sapiens	131-135
25146701-9	2014	The results indicate that CRF1 receptors in the dPAG play a pervasive role in the regulation of defensive responses associated with both generalized anxiety and panic.	dpag	48-52	corticotropin releasing hormone receptor 1	Homo sapiens	26-30
24409327-9	2014	However, the immunohistochemical analysis revealed that LPA 18:1 increased c-Fos expression in the DPAG.	dpag	99-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
24878577-4	2014	This LPS-induced hyperalgesia was accompanied by distinct recruitment of supra-spinal regions involved in analgesia as indicated by significantly attenuated Fos-protein induction in the rostral dorsal periaqueductal grey (DPAG) as well as rostral and caudal axes of the ventrolateral PAG (VLPAG).	dpag	222-226	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	157-160
23598399-3	2013	The obtained results showed that intra-dPAG administration of morphine significantly increased escape latency, a panicolytic-like effect that was blocked by pre-treatment with intra-dPAG injection of either naloxone or the 5-HT1A antagonist N-[2-[4-(2-methoxyphenyl)-1 piperazinyl] ethyl] -N- 2- pyridinyl-ciclohexanecarboxamide maleate (WAY-100635).	dpag	39-43	5-hydroxytryptamine receptor 1A	Rattus norvegicus	223-229
23598399-7	2013	These results suggest a synergic interaction between the 5-HT1A and the micro-opioid receptor at post-synaptic level on neurons of the dPAG that regulate proximal defense, theoretically related to panic attacks.	dpag	135-139	5-hydroxytryptamine receptor 1A	Rattus norvegicus	57-63
23787365-2	2013	In the dorsal periaqueductal gray matter (dPAG), another key panic-associated area, serotonin, through the activation of 5-HT1A and 5-HT2A receptors, exerts an inhibitory role on escape expression.	dpag	42-46	5-hydroxytryptamine receptor 1A	Rattus norvegicus	121-133
23787365-8	2013	The results indicate that 5-HT1A and 5-HT2A receptors within the DMH play a phasic inhibitory role upon escape expression, as previously reported in the dPAG.	dpag	153-157	5-hydroxytryptamine receptor 1A	Rattus norvegicus	26-38
21660445-3	2011	A proposal has been made that 5-HT2A receptor agonists exert their inhibitory effect on escape by activating GABAergic interneurons located in the dPAG.	dpag	147-151	5-hydroxytryptamine receptor 2A	Rattus norvegicus	30-36
21937980-2	2012	Given the cellular and behavioral evidence suggesting opposite functions for cannabinoid type 1 receptor (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1), we hypothesized that they could differentially influence panic-like reactions induced by electrical stimulation of the dPAG.	dpag	297-301	cannabinoid receptor 1	Rattus norvegicus	77-104
21937980-2	2012	Given the cellular and behavioral evidence suggesting opposite functions for cannabinoid type 1 receptor (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1), we hypothesized that they could differentially influence panic-like reactions induced by electrical stimulation of the dPAG.	dpag	297-301	cannabinoid receptor 1	Rattus norvegicus	106-109
21937980-2	2012	Given the cellular and behavioral evidence suggesting opposite functions for cannabinoid type 1 receptor (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1), we hypothesized that they could differentially influence panic-like reactions induced by electrical stimulation of the dPAG.	dpag	297-301	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	115-168
21937980-2	2012	Given the cellular and behavioral evidence suggesting opposite functions for cannabinoid type 1 receptor (CB1) and transient receptor potential vanilloid type-1 channel (TRPV1), we hypothesized that they could differentially influence panic-like reactions induced by electrical stimulation of the dPAG.	dpag	297-301	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	170-175
21937980-9	2012	Supporting this view, we observed that several neurons in the dPAG co-expressed CB1 and TRPV1.	dpag	62-66	cannabinoid receptor 1	Rattus norvegicus	80-83
21937980-9	2012	Supporting this view, we observed that several neurons in the dPAG co-expressed CB1 and TRPV1.	dpag	62-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	88-93
23707246-2	2013	Here, we attempt to show the role played by the TRPV1 receptors within the dorsal periaqueductal gray matter (dPAG), a midbrain structure strongly involved in the modulation of anxiety.	dpag	110-114	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	48-53
23007604-5	2013	We also investigated if CBD effects on the ETM depend on facilitation of 5-HT1A-mediated neurotransmission in the DPAG.	dpag	114-118	5-hydroxytryptamine receptor 1A	Rattus norvegicus	73-79
23007604-6	2013	To this latter aim, we verified if these effects would be prevented by intra-DPAG injection of the 5-HT1A receptor antagonist WAY100635 (0.37 nmol/0.2 muL).	dpag	77-81	5-hydroxytryptamine receptor 1A	Rattus norvegicus	99-105
23007604-7	2013	Also, we verified, by in vivo microdialysis, if CBD chronic treatment increases serotonin (5-HT) release and, by quantitative polymerase chain reaction, if there are changes in 5HT-1A or 5HT-2C mRNA expression in DPAG.	dpag	213-217	5-hydroxytryptamine receptor 1A	Rattus norvegicus	177-183
23007604-7	2013	Also, we verified, by in vivo microdialysis, if CBD chronic treatment increases serotonin (5-HT) release and, by quantitative polymerase chain reaction, if there are changes in 5HT-1A or 5HT-2C mRNA expression in DPAG.	dpag	213-217	5-hydroxytryptamine receptor 2C	Rattus norvegicus	187-193
23007604-10	2013	CBD effects were prevented by DPAG injection of the 5-HT1A receptor antagonist.	dpag	30-34	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-58
23007604-11	2013	CONCLUSIONS: Together, these findings suggest that repeated treatment with CBD induces anti-panic effects by acting on 5-HT1A receptors in DPAG.	dpag	139-143	5-hydroxytryptamine receptor 1A	Rattus norvegicus	119-125
23183042-11	2013	These data refute a cause-and-effect relationship between enhanced dPAG c-fos expression and a reduction in SR.	dpag	67-71	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-77
22450373-8	2012	These results suggest that CRFr1 plays an important role in the defensive behavior and antinociception produced by NO within the dPAG.	dpag	129-133	corticotropin releasing hormone receptor 1	Mus musculus	27-32
21660445-8	2011	The inhibitory effect caused by DOI, RO 60-0175, and mCPP was also blocked by previous intra-dPAG injection of the preferential 5-HT2A receptor antagonist ketanserin.	dpag	93-97	5-hydroxytryptamine receptor 2A	Rattus norvegicus	128-134
21660445-10	2011	CONCLUSIONS: Stimulation of 5-HT2A but not 5-HT2C receptors in the dPAG causes a panicolytic-like effect that is mediated by facilitation of GABAergic neurotransmission.	dpag	67-71	5-hydroxytryptamine receptor 2A	Rattus norvegicus	28-34
21683728-10	2011	Together, these data suggest differential, state-dependent alterations in electrophysiological activity and ERK phosphorylation along the PFC-amygdala-dPAG pathway during pain, conditioned fear, and FCA.	dpag	151-155	Eph receptor B1	Rattus norvegicus	108-111
20570114-10	2011	Although there is a high level of similarity between the behavioral effects obtained in rats (elevated T-maze) and mice (MDTB and RET) with the infusion of 5-HT agonists into the dPAG, the same is not true regarding the effects of blockade of DRN 5-HT(1A) receptors in these rodent species.	dpag	179-183	ret proto-oncogene	Mus musculus	130-133
21723867-2	2011	In rats, chemical stimulation of dPAG by local infusion of the neuropeptide corticotropin-releasing factor (CRF) provokes anxiogenic effects in the elevated plus-maze test (EPM).	dpag	33-37	corticotropin releasing hormone	Mus musculus	76-106
21723867-4	2011	Yet, given that there are CRF1 and CRF2 receptor subtypes within the PAG, it is important to show in which receptor subtypes CRF exert its anxiogenic and antinociceptive effects in the dPAG.	dpag	185-189	corticotropin releasing hormone receptor 2	Mus musculus	35-48
21421022-3	2011	Since reported evidence has implicated the 5-HT(1A) receptors of the dorsal periaqueductal gray matter (DPAG) in the panicolytic effect of antidepressants, rats treated with pindolol (5.0mg/kg, i.p.)	dpag	104-108	5-hydroxytryptamine receptor 1A	Homo sapiens	43-50
21421022-7	2011	These results implicate the 5-HT(1A) receptors of the DPAG in the panicolytic effect of the pindolol-paroxetine combination administered systemically.	dpag	54-58	5-hydroxytryptamine receptor 1A	Homo sapiens	28-35
20561964-10	2010	The results suggest that activation of the DPAG through the GLY(B)/NMDA receptor is able to produce either facilitation or inhibition of nociception depending on the nociceptive context.	dpag	43-47	Glycine auxotroph B, complementation of hamster	Homo sapiens	60-66
20850460-2	2011	Indirect evidence obtained with non-selective 5-HT2C-interacting drugs suggests that the same may occur in the dPAG, a brainstem region consistently implicated in the genesis/regulation of panic attacks.	dpag	111-115	5-hydroxytryptamine receptor 2C	Rattus norvegicus	46-52
20850460-9	2011	Overall, the results indicate that 5-HT2C receptors in the dPAG are preferentially involved in the regulation of defensive behaviors related to anxiety, but not panic.	dpag	59-63	5-hydroxytryptamine receptor 2C	Rattus norvegicus	35-41
20850460-10	2011	This finding extends to the dPAG the prominent role that has been attributed to 5-HT2C receptors in anxiety generation.	dpag	28-32	5-hydroxytryptamine receptor 2C	Rattus norvegicus	80-86
20457188-2	2010	Cannabidiol (CBD), a major non-psychotomimetic compound present in Cannabis sativa, causes anxiolytic-like effects after intra-dPAG microinjections by activating 5-HT1A receptors.	dpag	127-131	5-hydroxytryptamine receptor 1A	Rattus norvegicus	162-168
20457188-9	2010	Together, the results suggest that CBD causes panicolytic effects in the dPAG by activating 5-HT1A receptors.	dpag	73-77	5-hydroxytryptamine receptor 1A	Rattus norvegicus	92-98
20047714-10	2010	Bicuculline also blocked the inhibitory effect of BDNF on mean arterial pressure increase caused by electrical stimulation of DPAG.	dpag	126-130	brain-derived neurotrophic factor	Rattus norvegicus	50-54
20514481-7	2010	Ultrasound application increased c-Fos expression in the dorsal and dorsolateral PAG (dPAG, dlPAG) and amygdaloid subregions.	dpag	86-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-38
20478359-4	2010	The results showed that intra-dPAG injection of WAY-100635 or ketanserin, 5-HT(1A) and 5-HT(2A/2C) receptor antagonists, respectively, counteracted the anti-escape effect caused by bilateral intra-LHb injection of kainic acid (60pmol/0.2microl).	dpag	30-34	5-hydroxytryptamine receptor 1A	Rattus norvegicus	74-81
20478359-4	2010	The results showed that intra-dPAG injection of WAY-100635 or ketanserin, 5-HT(1A) and 5-HT(2A/2C) receptor antagonists, respectively, counteracted the anti-escape effect caused by bilateral intra-LHb injection of kainic acid (60pmol/0.2microl).	dpag	30-34	5-hydroxytryptamine receptor 2A	Rattus norvegicus	87-94
20478359-4	2010	The results showed that intra-dPAG injection of WAY-100635 or ketanserin, 5-HT(1A) and 5-HT(2A/2C) receptor antagonists, respectively, counteracted the anti-escape effect caused by bilateral intra-LHb injection of kainic acid (60pmol/0.2microl).	dpag	30-34	luteinizing hormone subunit beta	Rattus norvegicus	197-200
20478359-6	2010	Overall, the results suggest that the pathway connecting the LHb to the DRN is involved in the control of 5-HT release in the dPAG, and facilitation of 5-HT-mediated neurotransmission in the latter area distinctively impacts upon the expression of anxiety- and fear-related defensive behaviors.	dpag	126-130	luteinizing hormone subunit beta	Rattus norvegicus	61-64
20528764-6	2010	The reviewed results suggest that chronic, but not acute, administration of antidepressants suppress panic attacks by increasing the release of 5-HT and enhancing the responsivity of post-synaptic 5-HT1A and 5-HT2A receptors in the DPAG.	dpag	232-236	5-hydroxytryptamine receptor 1A	Homo sapiens	197-209
20528764-6	2010	The reviewed results suggest that chronic, but not acute, administration of antidepressants suppress panic attacks by increasing the release of 5-HT and enhancing the responsivity of post-synaptic 5-HT1A and 5-HT2A receptors in the DPAG.	dpag	232-236	5-hydroxytryptamine receptor 2A	Homo sapiens	210-214
20047714-4	2010	In this study we investigated the effect of intra-DPAG injection of BDNF in a proposed animal model of panic: the escape response evoked by the electrical stimulation of the same midbrain area.	dpag	50-54	brain-derived neurotrophic factor	Rattus norvegicus	68-72
20047714-11	2010	Therefore, in the DPAG, BDNF-TrkB signalling interacts with the GABAergic system to cause a panicolytic-like effect.	dpag	18-22	brain-derived neurotrophic factor	Rattus norvegicus	24-28
20047714-11	2010	Therefore, in the DPAG, BDNF-TrkB signalling interacts with the GABAergic system to cause a panicolytic-like effect.	dpag	18-22	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	29-33
19564136-2	2009	In a previous study, we reported that noradrenaline (NA) microinjection into the dPAG of rats caused pressor response that was mediated by vasopressin release.	dpag	81-85	arginine vasopressin	Rattus norvegicus	139-150
19631472-12	2010	TRH selective inhibition of DPAG-evoked defensive behaviors adds new evidence that panic attacks may be attenuated by increased levels of this hormone in hypothyroidism.	dpag	28-32	thyrotropin releasing hormone	Rattus norvegicus	0-3
19564136-11	2009	The results from cobalt treatment indicated that synapses in PVN mediate the vasopressin-induced pressor response caused by NA microinjection into the dPAG.	dpag	151-155	arginine vasopressin	Rattus norvegicus	77-88
19302815-2	2009	Previously, we reported that noradrenaline (NA) microinjection into the dPAG caused a pressor response that was mediated by vasopressin release into the circulation.	dpag	72-76	arginine vasopressin	Rattus norvegicus	124-135
18446327-10	2008	CONCLUSIONS: Alprazolam as antidepressants compounds facilitates 5-HT(1A)- and 5-HT(2A)-receptor-mediated neurotransmission in the DPAG, implicating this effect in the mode of action of different classes of antipanic drugs.	dpag	131-135	5-hydroxytryptamine receptor 1A	Rattus norvegicus	65-72
18076976-4	2008	The 5-HT1A function of the dPAG was evaluated by local injections of 8-OH-DPAT (4 and 8 nmol/0.2 microL) and WAY-100635 (10 nmol/0.2 microL), selective agonist and antagonist of 5-HT1A receptors, respectively.	dpag	27-31	5-hydroxytryptamine receptor 1A	Rattus norvegicus	4-10
18076976-4	2008	The 5-HT1A function of the dPAG was evaluated by local injections of 8-OH-DPAT (4 and 8 nmol/0.2 microL) and WAY-100635 (10 nmol/0.2 microL), selective agonist and antagonist of 5-HT1A receptors, respectively.	dpag	27-31	5-hydroxytryptamine receptor 1A	Rattus norvegicus	178-184
18076976-9	2008	Also, the reduction in the regulation of the defensive behaviors by 5-HT1A-mediated mechanisms in the dPAG of these animals may underlie the stress precipitated psychopathology associated with the neural substrates of aversion of the dPAG.	dpag	102-106	5-hydroxytryptamine receptor 1A	Rattus norvegicus	68-74
18076976-9	2008	Also, the reduction in the regulation of the defensive behaviors by 5-HT1A-mediated mechanisms in the dPAG of these animals may underlie the stress precipitated psychopathology associated with the neural substrates of aversion of the dPAG.	dpag	234-238	5-hydroxytryptamine receptor 1A	Rattus norvegicus	68-74
17045752-7	2007	injection of the panicogenic cholecystokinin (CCK)(B) receptor agonist pentagastrin (PG, 40 microg kg(-1)) produced an increase in firing rate in 12/17 (70%) of neurons tested in the dPAG.	dpag	183-187	cholecystokinin B receptor	Rattus norvegicus	29-62
17540371-6	2007	The aim of the present series of experiments was to directly evaluate the role of the CRF1 receptor (CRF1) in dPAG-induced defensive behaviors in the MDTB and the RET paradigms.	dpag	110-114	corticotropin releasing hormone receptor 1	Rattus norvegicus	86-90
17540371-6	2007	The aim of the present series of experiments was to directly evaluate the role of the CRF1 receptor (CRF1) in dPAG-induced defensive behaviors in the MDTB and the RET paradigms.	dpag	110-114	corticotropin releasing hormone receptor 1	Rattus norvegicus	101-105
17540371-9	2007	Collectively, these results implicate CRF1 in the dPAG as a mediator of temporally and spatially dependent avoidance in response to controllable and constant stimuli.	dpag	50-54	corticotropin releasing hormone receptor 1	Rattus norvegicus	38-42
17313964-1	2007	Behavioral evidence indicates that sensitization of 5-HT1A and 5-HT2A receptors in the dorsal periaqueductal gray (DPAG) may underlie the therapeutic effect of serotonin reuptake inhibitors (SRIs) in panic disorder.	dpag	115-119	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-64
17313964-3	2007	In this test, chronic administration of the non-selective SRI imipramine enhances the inhibitory effect on escape caused by the intra-DPAG injection of the 5-HT1A receptor agonist 8-OH-DPAT.	dpag	134-138	sorcin	Rattus norvegicus	58-61
17313964-3	2007	In this test, chronic administration of the non-selective SRI imipramine enhances the inhibitory effect on escape caused by the intra-DPAG injection of the 5-HT1A receptor agonist 8-OH-DPAT.	dpag	134-138	5-hydroxytryptamine receptor 1A	Rattus norvegicus	156-162
17313964-8	2007	The results indicate that chronic administration of fluoxetine and sertraline sensitizes 5-HT1A receptors in the DPAG.	dpag	113-117	5-hydroxytryptamine receptor 1A	Rattus norvegicus	89-95
17313964-9	2007	Overall, they support the view that facilitation of 5-HT1A receptor-mediated neurotransmission in the DPAG is implicated in the therapeutic effect of SRIs on panic disorder.	dpag	102-106	5-hydroxytryptamine receptor 1A	Rattus norvegicus	52-58
17900567-3	2007	The present paper examines the Fos-protein distribution in the brain of rats submitted to a conditioned place aversion (CPA) paradigm using the dPAG chemical stimulation with semicarbazide (SMC), an inhibitor of the GABA synthesizing enzyme, as US and the quadrant of an arena where the drug was injected as the paired neutral stimulus.	dpag	144-148	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
17320064-14	2007	These results demonstrate that nNOS within the dPAG plays a differential role in modulating cardiovascular responses and glutamatergic/GABAergic neurotransmission during thermal and mechanical nociception.	dpag	47-51	nitric oxide synthase 1	Rattus norvegicus	31-35
15342106-5	2004	We presently evaluate the role of the 5-HT1A, 5-HT2A and 5-HT2C receptors of the DPAG in the modulation of inhibitory avoidance and escape responses of rats submitted to the elevated T-maze.	dpag	81-85	5-hydroxytryptamine receptor 1A	Rattus norvegicus	38-44
15962186-11	2005	The present findings suggest that the 5-HT2A/2C receptor agonist has an inhibitory effect on maternal aggressive behavior when microinjected into the DPAG and no effect when microinjected into the MS. Ketanserin (1.0 microg/0.2 microl) decreased locomotion when microinjected into the DPAG and MS, but did not affect aggressive behavior.	dpag	150-154	5-hydroxytryptamine receptor 2A	Rattus norvegicus	38-44
15962186-11	2005	The present findings suggest that the 5-HT2A/2C receptor agonist has an inhibitory effect on maternal aggressive behavior when microinjected into the DPAG and no effect when microinjected into the MS. Ketanserin (1.0 microg/0.2 microl) decreased locomotion when microinjected into the DPAG and MS, but did not affect aggressive behavior.	dpag	285-289	5-hydroxytryptamine receptor 2A	Rattus norvegicus	38-44
15962186-12	2005	We interpret these findings as evidence for a specific role of 5-HT2A/2C receptors in the DPAG in the inhibition of female aggressive behavior, dissociated from those on motor activity.	dpag	90-94	5-hydroxytryptamine receptor 2A	Rattus norvegicus	63-69
15165987-6	2004	On the other hand, in nonpretreated rats, the inhibitory effect of dPAG stimulation on the cardiac baroreflex response could be markedly reduced by prior intra-NTS microinjection of granisetron, a 5-HT(3) receptor antagonist, or bicuculline, a GABA(A) receptor antagonist.	dpag	67-71	5-hydroxytryptamine receptor 3A	Rattus norvegicus	197-213
15265647-11	2004	Thus, the present results support the Fos data and indicate that the DPAG is involved in the expression of some but not all of the cardiovascular and behavioral components of the response to cat odor.	dpag	69-73	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-41
16367785-10	2005	The results suggest that activation of noradrenergic receptors within the dPAG can evoke pressor responses, which are mediated by acute vasopressin release.	dpag	74-78	arginine vasopressin	Rattus norvegicus	136-147
16231166-4	2005	We also investigated whether the 5-HT(1A) and 5-HT(2A) receptors in the DPAG mediate the behavioral consequences induced by the injection of WAY-100635 into the DRN.	dpag	72-76	5-hydroxytryptamine receptor 1A	Rattus norvegicus	33-40
16170231-3	2005	In the present study we further explore the hypothesis that sensitization of 5-HT1A and 5-HT 2 A receptors in the DPAG is involved in the anti-panic effect of imipramine.	dpag	114-118	5-hydroxytryptamine receptor 1A	Rattus norvegicus	77-89
16170231-11	2005	Therefore, chronic imipramine seems to sensitize both 5-HT1A and 5-HT 2 A receptors in the DPAG, strengthening the view that these receptors are involved in the mode of action of anti-panic drugs.	dpag	91-95	5-hydroxytryptamine receptor 1A	Rattus norvegicus	54-66
15649440-1	2005	Freezing and escape responses induced by gradual increases in the intensity of the electrical current applied to dorsal regions of the periaqueductal gray (dPAG) cause a distinct pattern of Fos distribution in the brain.	dpag	156-160	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	190-193
15649440-4	2005	To examine further this issue we measured Fos protein expression in brain areas activated by stimulation of the dPAG with glutamate (5 nmol/0.2 microL) and N-methyl-D-aspartate (NMDA) at doses that provoke either freezing (4 nmol/0.2 microL) or escape (7 nmol/0.2 microL) responses, respectively.	dpag	112-116	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-45
15501525-9	2004	The results showed that both the intraperitoneal and intra-DPAG injections of CCK-8s potentiated one-way escape behavior, suggesting a panicogenic action.	dpag	59-63	cholecystokinin	Rattus norvegicus	78-81
15501525-12	2004	Also, the results provide further evidence about the involvement of a CCK-mediated mechanism within the DPAG in the regulation of panic-related defensive behaviors.	dpag	104-108	cholecystokinin	Rattus norvegicus	70-73
15342106-5	2004	We presently evaluate the role of the 5-HT1A, 5-HT2A and 5-HT2C receptors of the DPAG in the modulation of inhibitory avoidance and escape responses of rats submitted to the elevated T-maze.	dpag	81-85	5-hydroxytryptamine receptor 2A	Rattus norvegicus	46-58
15342106-6	2004	The results showed that intra-DPAG administration of the 5-HT1A receptor antagonist WAY-100635 and of the preferential antagonists of 5-HT2A and 5-HT2C receptors, ketanserin and SDZ SER 082, respectively, did not change rat behavior in the elevated T-maze.	dpag	30-34	5-hydroxytryptamine receptor 1A	Rattus norvegicus	57-63
15342106-9	2004	Intra-DPAG injection of the 5-HT1A agonist 8-OH-DPAT and of DOI, a preferential 5-HT2A agonist, also inhibited escape, an effect antagonized by WAY-100635 and ketanserin, respectively.	dpag	6-10	5-hydroxytryptamine receptor 1A	Rattus norvegicus	28-34
15342106-9	2004	Intra-DPAG injection of the 5-HT1A agonist 8-OH-DPAT and of DOI, a preferential 5-HT2A agonist, also inhibited escape, an effect antagonized by WAY-100635 and ketanserin, respectively.	dpag	6-10	5-hydroxytryptamine receptor 2A	Rattus norvegicus	80-86
15342106-11	2004	5-HT1A and 5-HT2C receptors in the DPAG play an opposite role in inhibitory avoidance: whereas activation of the former receptors inhibits the acquisition of this response, activation of the latter facilitates it.	dpag	35-39	5-hydroxytryptamine receptor 1A	Rattus norvegicus	0-6
14583742-9	2004	CCK-8s injected into the dPAG induced Fos immunoreactivity in several brain areas related to defensive behavior, including the PAG, median, and dorsal raphe nuclei, superior colliculus, lateral septal nuclei, medial hypothalamus, and medial amygdala.	dpag	25-29	cholecystokinin	Rattus norvegicus	0-3
14583742-3	2004	The objective of this study was to investigate a possible anxiogenic effect of CCK-8 microinjected into the dPAG.	dpag	108-112	cholecystokinin	Rattus norvegicus	79-82
14583742-9	2004	CCK-8s injected into the dPAG induced Fos immunoreactivity in several brain areas related to defensive behavior, including the PAG, median, and dorsal raphe nuclei, superior colliculus, lateral septal nuclei, medial hypothalamus, and medial amygdala.	dpag	25-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-41
14583742-11	2004	These results suggest that CCK-8s, acting on CCK-2 receptors, may modulate anxiety reactions in the dPAG.	dpag	100-104	cholecystokinin	Rattus norvegicus	27-30
14583742-11	2004	These results suggest that CCK-8s, acting on CCK-2 receptors, may modulate anxiety reactions in the dPAG.	dpag	100-104	cholecystokinin	Rattus norvegicus	45-48
14642639-3	2003	The CBF effects evoked from DPAG and VPAG by chemical stimulation were preserved in spinalized rats supporting that the evoked CBF responses result directly from stimulation and are not secondary to AP changes.	dpag	28-32	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-7
14642639-3	2003	The CBF effects evoked from DPAG and VPAG by chemical stimulation were preserved in spinalized rats supporting that the evoked CBF responses result directly from stimulation and are not secondary to AP changes.	dpag	28-32	CCAAT/enhancer binding protein zeta	Rattus norvegicus	127-130
12815018-11	2003	Pretreatment with the VR1 receptor antagonist, capsazepine (10 nmol in 0.4 microl), into the dPAG blocked the capsaicin-induced hyperalgesia as well as the corresponding changes in on- and off-cell activity.	dpag	93-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-25
12815018-12	2003	VR1 receptor immunostaining was observed in the dPAG of untreated rats.	dpag	48-52	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-3
11091933-5	2000	The stress effect was reversed by intra-DPAG injection of alpha-helical-CRH9-41 (0.5 microgram).	dpag	40-44	corticotropin releasing hormone	Rattus norvegicus	72-75
12900043-2	2003	A previous Fos study also revealed a marked activation of the ventrolateral part of the periaqueductal gray (VLPAG) and a much smaller activation of its dorsal part (DPAG).	dpag	166-170	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-14
12900043-4	2003	We now test the role of the DPAG to see if its small activation (as revealed by Fos) is of any functional significance in the contextual fear response.	dpag	28-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	80-83
12062564-6	2002	The results suggest that sensitization of both 5-HT(1A) and 5-HT(2) receptors within the DPAG may be involved in the beneficial effect of imipramine in panic disorder (PD).	dpag	89-93	5-hydroxytryptamine receptor 1A	Rattus norvegicus	47-54
11801295-5	2001	Microinjection of NMDA/GLY(B) receptor agonists within the dPAG during test sessions in the EPM resulted in an enduring learned fear response detected in the retest.	dpag	59-63	Glycine auxotroph B, complementation of hamster	Homo sapiens	18-29
11091933-6	2000	These results suggest that the anxiogenic behavior of rats previously stressed by forced immobilization might involve facilitation of CRH-mediated neurotransmission in the DPAG.	dpag	172-176	corticotropin releasing hormone	Rattus norvegicus	134-137
9835395-3	1998	Evidence from a previous study suggests an involvement of SP in the neural substrates of aversion in the dorsal periaqueductal gray matter (DPAG).	dpag	140-144	tachykinin precursor 1	Homo sapiens	58-60
9835395-7	1998	The proaversive effects observed with DPAG microinjections of these neuropeptides in the present study gain further relevance when combined with previous reports showing unconditioned and conditioned aversive effects following DPAG microinjections of SP in the place aversion and the elevated plus maze tests, two widely used animal models of anxiety.	dpag	38-42	tachykinin precursor 1	Homo sapiens	251-253
9835395-7	1998	The proaversive effects observed with DPAG microinjections of these neuropeptides in the present study gain further relevance when combined with previous reports showing unconditioned and conditioned aversive effects following DPAG microinjections of SP in the place aversion and the elevated plus maze tests, two widely used animal models of anxiety.	dpag	227-231	tachykinin precursor 1	Homo sapiens	251-253
9835395-8	1998	These results confirm previous data showing that SP has a modulatory role in the DPAG and that its effects are probably due to its C-terminal fragment.	dpag	81-85	tachykinin precursor 1	Homo sapiens	49-51
9760107-1	1998	We have reported previously that the NPY Y1 receptor antagonist BIBP3226 applied into the dorsal periaqueductal gray matter (DPAG) has an anxiogenic-like effect in the elevated plus-maze test in rats.	dpag	125-129	neuropeptide Y	Rattus norvegicus	37-40
10475723-1	1999	Acute systemic administration of the selective serotonin (5-HT)1A receptor full agonist flesinoxan enhanced the sensitivity of rats to the panic-like aversion elicited by local stimulation of the dorsolateral periaqueductal grey (dPAG).	dpag	230-234	5-hydroxytryptamine receptor 1A	Rattus norvegicus	47-74
9802417-9	1998	These data suggest that endogenous NPY may regulate anxiety-related behaviour in rats by acting via the NPY Y1 receptors in DPAG.	dpag	124-128	neuropeptide Y	Rattus norvegicus	35-38
9802417-9	1998	These data suggest that endogenous NPY may regulate anxiety-related behaviour in rats by acting via the NPY Y1 receptors in DPAG.	dpag	124-128	neuropeptide Y	Rattus norvegicus	104-107
9760107-4	1998	These results provide additional evidence that NPY-ergic neurotransmission in the DPAG may be involved in the modulation of anxiety-related behaviour and suggest that endogenous NPY, released under stressful conditions in the DPAG, relieves anxiety via the NPY Y1 receptors.	dpag	82-86	neuropeptide Y	Rattus norvegicus	47-50
9760107-4	1998	These results provide additional evidence that NPY-ergic neurotransmission in the DPAG may be involved in the modulation of anxiety-related behaviour and suggest that endogenous NPY, released under stressful conditions in the DPAG, relieves anxiety via the NPY Y1 receptors.	dpag	226-230	neuropeptide Y	Rattus norvegicus	47-50
9760107-4	1998	These results provide additional evidence that NPY-ergic neurotransmission in the DPAG may be involved in the modulation of anxiety-related behaviour and suggest that endogenous NPY, released under stressful conditions in the DPAG, relieves anxiety via the NPY Y1 receptors.	dpag	226-230	neuropeptide Y	Rattus norvegicus	178-181
9760107-4	1998	These results provide additional evidence that NPY-ergic neurotransmission in the DPAG may be involved in the modulation of anxiety-related behaviour and suggest that endogenous NPY, released under stressful conditions in the DPAG, relieves anxiety via the NPY Y1 receptors.	dpag	226-230	neuropeptide Y	Rattus norvegicus	178-181
8985712-2	1996	An experimental situation in rats measuring dPAG stimulation self-interruption thresholds has been validated as realistically simulating several aspects of panic anxiety with objective signs of symptomatic and predictive validity using established antipanic and panicogenic agents; it was utilized here to evaluate the effects of various cholecystokinin B receptor ligands.	dpag	44-48	cholecystokinin B receptor	Rattus norvegicus	338-364
9813486-0	1997	[Effect of vasopressin in the rostral ventrolateral medulla on pressor response induced by dPAG stimulation].	dpag	91-95	arginine vasopressin	Rattus norvegicus	11-22
9427334-2	1997	administered corticotropin-releasing hormone (CRH), rats (n = 6-13) received microinjections into the DPAG of CRH (1 or 2 microg) or saline and were tested on the elevated plus maze.	dpag	102-106	corticotropin releasing hormone	Rattus norvegicus	110-113
9427334-4	1997	In a second experiment the anxiogenic effect of intra-DPAG CRH (2 microg) was prevented by previous microinjection of alpha-helical-CRH(9-41) (0.5 microg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 +/- 3.7, alpha-helical-CRH(9-41) + CRH 45.7 +/- 1.6).	dpag	54-58	corticotropin releasing hormone	Rattus norvegicus	59-62
9427334-4	1997	In a second experiment the anxiogenic effect of intra-DPAG CRH (2 microg) was prevented by previous microinjection of alpha-helical-CRH(9-41) (0.5 microg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 +/- 3.7, alpha-helical-CRH(9-41) + CRH 45.7 +/- 1.6).	dpag	54-58	corticotropin releasing hormone	Rattus norvegicus	132-135
9427334-4	1997	In a second experiment the anxiogenic effect of intra-DPAG CRH (2 microg) was prevented by previous microinjection of alpha-helical-CRH(9-41) (0.5 microg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 +/- 3.7, alpha-helical-CRH(9-41) + CRH 45.7 +/- 1.6).	dpag	54-58	corticotropin releasing hormone	Rattus norvegicus	132-135
9427334-4	1997	In a second experiment the anxiogenic effect of intra-DPAG CRH (2 microg) was prevented by previous microinjection of alpha-helical-CRH(9-41) (0.5 microg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 +/- 3.7, alpha-helical-CRH(9-41) + CRH 45.7 +/- 1.6).	dpag	54-58	corticotropin releasing hormone	Rattus norvegicus	132-135
9427334-4	1997	In a second experiment the anxiogenic effect of intra-DPAG CRH (2 microg) was prevented by previous microinjection of alpha-helical-CRH(9-41) (0.5 microg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 +/- 3.7, alpha-helical-CRH(9-41) + CRH 45.7 +/- 1.6).	dpag	54-58	corticotropin releasing hormone	Rattus norvegicus	132-135
9427334-4	1997	In a second experiment the anxiogenic effect of intra-DPAG CRH (2 microg) was prevented by previous microinjection of alpha-helical-CRH(9-41) (0.5 microg), a CRH antagonist (percentage of entries into open arms: saline + CRH 20.3 +/- 3.7, alpha-helical-CRH(9-41) + CRH 45.7 +/- 1.6).	dpag	54-58	corticotropin releasing hormone	Rattus norvegicus	132-135
9389166-4	1996	When both NRO and dPAG were stimulated, Fos- like immunoreactive (FLI) cells in the ventral periaqueductal grey (vPAG) and paragigantocellularis lateralis (PGL) were increased as compared with cases in which the stimulation was only delivered to dPAG, i.e., reaching a FLI cell count value of 66.5 +/- 8.3 and 10.8 +/- 1.5 respectively.	dpag	18-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-43
9389166-4	1996	When both NRO and dPAG were stimulated, Fos- like immunoreactive (FLI) cells in the ventral periaqueductal grey (vPAG) and paragigantocellularis lateralis (PGL) were increased as compared with cases in which the stimulation was only delivered to dPAG, i.e., reaching a FLI cell count value of 66.5 +/- 8.3 and 10.8 +/- 1.5 respectively.	dpag	246-250	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-43
7501649-6	1995	These results indicate that activation of 5-HT1A and 5-HT2A receptors inhibits aversion in the DPAG and that both receptors have to be functional for the expression of each one"s activation to occur.	dpag	95-99	5-hydroxytryptamine receptor 1A	Rattus norvegicus	42-54
11401004-11	2001	Microinjections of methysergide, a non-specific antagonist of 5-HT receptors, or ketanserin, an antagonist of 5-HT2A receptors, into the dPAG before testing significantly inhibited the antinociception without affecting any of the behavioral or autonomic conditioned responses.	dpag	137-141	5-hydroxytryptamine receptor 2A	Rattus norvegicus	110-116
11224050-2	1991	The present results show that microinjection into the DPAG of isamoltane (4-32nmol) a beta-blocking agent that binds to 5-HT(1B) receptors more selectively than propranolol, raised the threshold of aversive electrical stimulation of the rat DPAG in a dose-dependent manner.	dpag	54-58	5-hydroxytryptamine receptor 1B	Rattus norvegicus	120-127
11224050-4	1991	Therefore, the antiaversive effect of beta-adrenoceptor/5-HT(1B) receptor antagonists injected into the DPAG is likely to be mediated by endogenous 5-HT, through activation of 5-HT(2) receptors.	dpag	104-108	5-hydroxytryptamine receptor 1B	Rattus norvegicus	56-63
30405240-6	2018	mPFC-dPAG neurons display robust shock-induced excitations, as visualized by single-cell, projection-defined microendoscopic calcium imaging.	dpag	5-9	complement factor properdin	Mus musculus	0-4
34500037-8	2021	In addition, exodontia induction resulted in an upregulation of FosB/DeltaFosB in the CeA, PVN and dPAG, while UCS and exodontia + UCS upregulate FosB/DeltaFosB immunoreactivity in the CeA, PVN, dPAG and NAc.	dpag	99-103	FosB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-68
32376258-4	2020	This study investigated the involvement and a likely interplay between CB1 and MOR receptors localized into the dPAG on the regulation of fear-like defensive responses and antinociception (evaluated in tail-flick test) evoked by dPAG chemical stimulation with N-methyl-d-aspartate (NMDA).	dpag	112-116	opioid receptor mu 1	Homo sapiens	79-82
32376258-4	2020	This study investigated the involvement and a likely interplay between CB1 and MOR receptors localized into the dPAG on the regulation of fear-like defensive responses and antinociception (evaluated in tail-flick test) evoked by dPAG chemical stimulation with N-methyl-d-aspartate (NMDA).	dpag	229-233	cannabinoid receptor 1	Homo sapiens	71-74
32376258-4	2020	This study investigated the involvement and a likely interplay between CB1 and MOR receptors localized into the dPAG on the regulation of fear-like defensive responses and antinociception (evaluated in tail-flick test) evoked by dPAG chemical stimulation with N-methyl-d-aspartate (NMDA).	dpag	229-233	opioid receptor mu 1	Homo sapiens	79-82
30991078-2	2019	BDNF mediates the panicolytic effect induced by antidepressant drugs and produces these effects per se when injected into the dPAG.	dpag	126-130	brain-derived neurotrophic factor	Rattus norvegicus	0-4
30991078-3	2019	Based on these findings, we hypothesize that nitric oxide synthase (NOS) inhibitors would have panicolytic properties associated with increased BDNF signaling in the dPAG.	dpag	166-170	brain-derived neurotrophic factor	Rattus norvegicus	144-148
30991078-5	2019	Repeated, but not acute, AMG administration (15 mg/kg) also decreased nitrite levels and increased TRKB phosphorylation at residues Y706/7 in the dPAG.	dpag	146-150	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	99-103
30991078-6	2019	Notwithstanding the lack of AMG effect on total BDNF levels in this structure, the microinjection of the TRK antagonist K252a into the dPAG blocked the anti-escape effect of this drug in the ETM.	dpag	135-139	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	105-108
30770101-0	2019	NO in the dPAG modulates panic-like responses and ASIC1a expression in the prefrontal cortex and hippocampus in mice.	dpag	10-14	acid-sensing (proton-gated) ion channel 1	Mus musculus	50-56
30770101-11	2019	The present study suggests that the NO pathway in the dPAG plays a key role in panic-like responses in mice confronted by a rat, further, NO intra-dPAG injection also modulates the ASIC1a expression levels in the PFC and hippocampus.	dpag	54-58	acid-sensing (proton-gated) ion channel 1	Mus musculus	181-187
30770101-11	2019	The present study suggests that the NO pathway in the dPAG plays a key role in panic-like responses in mice confronted by a rat, further, NO intra-dPAG injection also modulates the ASIC1a expression levels in the PFC and hippocampus.	dpag	147-151	acid-sensing (proton-gated) ion channel 1	Mus musculus	181-187
30056125-6	2018	These results suggest that OAA is mediated by 5-HT2C receptors within the dPAG.	dpag	74-78	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	46-52
30405240-7	2018	Finally, photostimulation of dopamine terminals in the mPFC reveals an increase in the signal-to-noise ratio in mPFC-dPAG responses to aversive stimuli.	dpag	117-121	complement factor properdin	Mus musculus	55-59
30405240-7	2018	Finally, photostimulation of dopamine terminals in the mPFC reveals an increase in the signal-to-noise ratio in mPFC-dPAG responses to aversive stimuli.	dpag	117-121	complement factor properdin	Mus musculus	112-116
29519453-13	2018	These findings suggest that NK1 receptors are activated in both the VH and CeA during the processing of aversive information that derives from dPAG-ES.	dpag	143-147	carcinoembryonic antigen gene family 4	Rattus norvegicus	75-78
28554847-2	2017	Studies with drugs that interfere with serotonin-mediated neurotransmission suggest that the mu-opioid receptor (MOR) synergistically interacts with the 5-HT1A receptor in the dPAG to inhibit escape, a panic-related behavior.	dpag	176-180	opioid receptor mu 1	Homo sapiens	93-111
28799955-7	2017	An intra-dPAG injection of the 5-HT1A receptor agonist (+-)-8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) increased the [INCREMENT] threshold in both DBT and NGL, suggesting a panicolytic-like effect.	dpag	9-13	5-hydroxytryptamine receptor 1A	Rattus norvegicus	31-37
28799955-8	2017	DBT animals presented a more pronounced panicolytic-like response compared with NGL as a higher [INCREMENT] threshold was observed after 8-OH-DPAT treatment, which could be a consequence of the increased expression of the 5-HT1A receptor in the dPAG from DBT animals.	dpag	245-249	5-hydroxytryptamine receptor 1A	Rattus norvegicus	222-228
28797641-3	2017	This study further analyzes the mechanism of opiorphin panicolytic action, using the EST and drug injection inside the dPAG.	dpag	119-123	opiorphin prepropeptide	Homo sapiens	45-54
28797641-7	2017	Therefore, the anti-escape effect of opiorphin in the dPAG seems to be mediated by endogenous bradykinin, acting on kinin B2 receptors, which previous results have shown to interact synergistically with MOR in the dPAG to restrain escape in two animal models of panic.	dpag	54-58	opiorphin prepropeptide	Homo sapiens	37-46
28797641-7	2017	Therefore, the anti-escape effect of opiorphin in the dPAG seems to be mediated by endogenous bradykinin, acting on kinin B2 receptors, which previous results have shown to interact synergistically with MOR in the dPAG to restrain escape in two animal models of panic.	dpag	54-58	kininogen 1	Homo sapiens	94-104
28797641-7	2017	Therefore, the anti-escape effect of opiorphin in the dPAG seems to be mediated by endogenous bradykinin, acting on kinin B2 receptors, which previous results have shown to interact synergistically with MOR in the dPAG to restrain escape in two animal models of panic.	dpag	214-218	opiorphin prepropeptide	Homo sapiens	37-46
28797641-7	2017	Therefore, the anti-escape effect of opiorphin in the dPAG seems to be mediated by endogenous bradykinin, acting on kinin B2 receptors, which previous results have shown to interact synergistically with MOR in the dPAG to restrain escape in two animal models of panic.	dpag	214-218	kininogen 1	Homo sapiens	94-104
28797641-7	2017	Therefore, the anti-escape effect of opiorphin in the dPAG seems to be mediated by endogenous bradykinin, acting on kinin B2 receptors, which previous results have shown to interact synergistically with MOR in the dPAG to restrain escape in two animal models of panic.	dpag	214-218	opioid receptor mu 1	Homo sapiens	203-206
28554847-2	2017	Studies with drugs that interfere with serotonin-mediated neurotransmission suggest that the mu-opioid receptor (MOR) synergistically interacts with the 5-HT1A receptor in the dPAG to inhibit escape, a panic-related behavior.	dpag	176-180	opioid receptor mu 1	Homo sapiens	113-116
28554847-2	2017	Studies with drugs that interfere with serotonin-mediated neurotransmission suggest that the mu-opioid receptor (MOR) synergistically interacts with the 5-HT1A receptor in the dPAG to inhibit escape, a panic-related behavior.	dpag	176-180	5-hydroxytryptamine receptor 1A	Homo sapiens	153-168
28554847-4	2017	The latter evidence, points to an interaction between BK and opioids in the dPAG.	dpag	76-80	kininogen 1	Homo sapiens	54-56
28554847-7	2017	Our results showed that intra-dPAG injection of BK inhibited escape performance in a dose-dependent way, and this panicolytic-like effect was blocked by the BK type 2 receptor (B2R) antagonist HOE-140, and by the selective MOR antagonist CTOP.	dpag	30-34	kininogen 1	Homo sapiens	48-50
28554847-7	2017	Our results showed that intra-dPAG injection of BK inhibited escape performance in a dose-dependent way, and this panicolytic-like effect was blocked by the BK type 2 receptor (B2R) antagonist HOE-140, and by the selective MOR antagonist CTOP.	dpag	30-34	bradykinin receptor B2	Homo sapiens	157-175
28554847-7	2017	Our results showed that intra-dPAG injection of BK inhibited escape performance in a dose-dependent way, and this panicolytic-like effect was blocked by the BK type 2 receptor (B2R) antagonist HOE-140, and by the selective MOR antagonist CTOP.	dpag	30-34	bradykinin receptor B2	Homo sapiens	177-180
28554847-9	2017	Finally, intra-dPAG injection of captopril also impaired escape in a dose-dependent way, and this panicolytic-like effect was blocked by pretreatment with HOE-140, suggesting mediation by endogenous BK.	dpag	15-19	kininogen 1	Homo sapiens	199-201
28148494-9	2017	This study demonstrates that reduced anandamide content and upregulation of FAAH in the dPAG are associated with hyperalgesia and reduced heart rate sustained weeks after nerve injury.	dpag	88-92	fatty-acid amide hydrolase-like	Rattus norvegicus	76-80
28347824-3	2017	The 5-HT1A receptor (5-HT1A-R) is involved in regulating escape behavior that is organized in the dPAG.	dpag	98-102	5-hydroxytryptamine receptor 1A	Homo sapiens	4-19
28347824-3	2017	The 5-HT1A receptor (5-HT1A-R) is involved in regulating escape behavior that is organized in the dPAG.	dpag	98-102	5-hydroxytryptamine receptor 1A	Homo sapiens	21-29
28347824-7	2017	We also evaluated whether activation of the 5-HT1A-R or the mu-opioid receptor (MOR) in the dPAG contributes to the Nor-BNI effects.	dpag	92-96	opioid receptor mu 1	Homo sapiens	60-78
28347824-7	2017	We also evaluated whether activation of the 5-HT1A-R or the mu-opioid receptor (MOR) in the dPAG contributes to the Nor-BNI effects.	dpag	92-96	opioid receptor mu 1	Homo sapiens	80-83
28347824-12	2017	These results indicate that KOR enhances proximal defense in the dPAG through 5-HT1A-R modulation, independently of MOR.	dpag	65-69	opioid receptor kappa 1	Homo sapiens	28-31
28347824-12	2017	These results indicate that KOR enhances proximal defense in the dPAG through 5-HT1A-R modulation, independently of MOR.	dpag	65-69	5-hydroxytryptamine receptor 1A	Homo sapiens	78-86
26320545-1	2015	Previously reported results have shown that the inhibitory effect of fluoxetine on escape behavior, interpreted as a panicolytic-like effect, is blocked by pretreatment with either the opioid receptor antagonist naloxone or the 5-HT1A receptor (5-HT1A-R) antagonist WAY100635 via injection into the dorsal periaqueductal gray matter (dPAG).	dpag	334-338	5-hydroxytryptamine receptor 1A	Homo sapiens	228-243
27856260-8	2017	Furthermore, Fos protein-labelled neurons were observed in the dPAG after the stimulation of the dmVMH with 9nmol of NMDA.	dpag	63-67	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	13-16
27280429-8	2016	These data indicate that in the dPAG, anandamide, a FAAH-regulated lipid, contributes to regulation of baseline heart rate through influences on autonomic outflow.	dpag	32-36	fatty-acid amide hydrolase-like	Rattus norvegicus	52-56
27059332-8	2016	Moreover, the results of the present study suggest that 5-HT2C receptor activation in the dPAG is not critically involved in the control of predator-evoked fearful or antinociceptive responses.	dpag	90-94	5-hydroxytryptamine (serotonin) receptor 2C	Mus musculus	56-71
26320545-1	2015	Previously reported results have shown that the inhibitory effect of fluoxetine on escape behavior, interpreted as a panicolytic-like effect, is blocked by pretreatment with either the opioid receptor antagonist naloxone or the 5-HT1A receptor (5-HT1A-R) antagonist WAY100635 via injection into the dorsal periaqueductal gray matter (dPAG).	dpag	334-338	5-hydroxytryptamine receptor 1A	Homo sapiens	245-253
26320545-2	2015	Additionally, reported evidence indicates that the mu-opioid receptor (MOR) interacts with the 5-HT1A-R in the dPAG.	dpag	111-115	opioid receptor mu 1	Homo sapiens	51-69
26320545-2	2015	Additionally, reported evidence indicates that the mu-opioid receptor (MOR) interacts with the 5-HT1A-R in the dPAG.	dpag	111-115	opioid receptor mu 1	Homo sapiens	71-74
26320545-2	2015	Additionally, reported evidence indicates that the mu-opioid receptor (MOR) interacts with the 5-HT1A-R in the dPAG.	dpag	111-115	5-hydroxytryptamine receptor 1A	Homo sapiens	95-103
26320545-3	2015	In the present work, pretreatment of the dPAG with the selective MOR blocker CTOP antagonized the anti-escape effect of chronic fluoxetine (10 mg/kg, i.p., daily, for 21 days), as measured in the elevated T-maze (ETM) test, indicating mediation of this effect by the MOR.	dpag	41-45	opioid receptor mu 1	Homo sapiens	65-68
26320545-3	2015	In the present work, pretreatment of the dPAG with the selective MOR blocker CTOP antagonized the anti-escape effect of chronic fluoxetine (10 mg/kg, i.p., daily, for 21 days), as measured in the elevated T-maze (ETM) test, indicating mediation of this effect by the MOR.	dpag	41-45	opioid receptor mu 1	Homo sapiens	267-270
26320545-4	2015	In addition, the combined administration of sub-effective doses of the selective MOR agonist DAMGO (intra-dPAG) and sub-effective doses of chronic as well as subchronic (7 days) fluoxetine increased avoidance and escape latencies, suggesting that the activation of MORs may facilitate and accelerate the effects of fluoxetine.	dpag	106-110	opioid receptor mu 1	Homo sapiens	81-84
25485771-8	2015	In contrast, treating the dPAG with the kappa-opioid receptor agonist salvinorin-A increased the frequency [F(3,36)=12.4; p<0.01] and duration [F(3,34)=16.1; p<0.01] of defensive immobility induced by GABAA receptor blockade in the IC.	dpag	26-30	opioid receptor kappa 1	Homo sapiens	40-61
26183651-1	2015	Recent findings have identified the presence of transient receptor potential vanilloid-1 (TRPV1) channels within the dorsal portion of the periaqueductal gray (dPAG), suggesting their involvement in the control of pain and environmentally-induced antinociception.	dpag	160-164	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	48-88
26183651-1	2015	Recent findings have identified the presence of transient receptor potential vanilloid-1 (TRPV1) channels within the dorsal portion of the periaqueductal gray (dPAG), suggesting their involvement in the control of pain and environmentally-induced antinociception.	dpag	160-164	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	90-95
26183651-3	2015	Here, we investigated the role of these TRPV1 channels within the dPAG in the modulation of a tonic pain and in the oEPM-induced antinociception.	dpag	66-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-45
26183651-8	2015	Our results revealed an important role of TRPV1 channels within the dPAG in the modulation of pain and in the phenomenon known as fear-induced antinociception in mice.	dpag	68-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
25567506-10	2015	Moreover, c-Fos study shows the optical stimulation activates restricted range in midbrain: the optical stimulation affected only dPAG and its downstreams but electric stimulation activates both the upstream and downstream circuits, in which the glutamatergic neurons are largely occupied and play important role in "Stop" and "Escape" behavior controls.	dpag	130-134	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	10-15
25883049-13	2015	The long-lasting consequences of electrical stimulation of the dPAG may be prevented by NK1 receptor antagonism in the CeA.	dpag	63-67	tachykinin receptor 1	Rattus norvegicus	88-100
25617821-2	2015	In a previous study, we showed that noradrenaline (NA) microinjected into the dPAG caused a vasopressin-mediated pressor response, involving a relay in the hypothalamic paraventricular nucleus (PVN).	dpag	78-82	arginine vasopressin	Rattus norvegicus	92-103
25617821-7	2015	In conclusion, the present results suggest that bilateral PVN activation of non-NMDA glutamate receptors mediates the vasopressin-related cardiovascular response to the microinjection of NA into the dPAG.	dpag	199-203	arginine vasopressin	Rattus norvegicus	118-129
25840741-3	2015	In the present study we evaluated the participation of the BDNF-TRKB system of the dorsal periaqueductal gray matter (DPAG), a core structure involved in the pathophysiology of panic disorder, in AD-induced panicolytic-like effects in rats.	dpag	118-122	brain-derived neurotrophic factor	Rattus norvegicus	59-63
25840741-3	2015	In the present study we evaluated the participation of the BDNF-TRKB system of the dorsal periaqueductal gray matter (DPAG), a core structure involved in the pathophysiology of panic disorder, in AD-induced panicolytic-like effects in rats.	dpag	118-122	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	64-68
25840741-4	2015	The results showed that short- (3 days) or long-term (21 days) systemic treatment with the tricyclic ADs imipramine, clomipramine or desipramine increased BDNF levels in the DPAG.	dpag	174-178	brain-derived neurotrophic factor	Rattus norvegicus	155-159
25840741-8	2015	Imipramine, both after short and long-term administration, and fluoxetine under the latter regimen, raised the levels of phosphorylated TRKB in the DPAG.	dpag	148-152	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	136-140
25840741-11	2015	Altogether, our data suggests that facilitation of the BDNF-TRKB system in the DPAG is implicated in the panicolytic effect of ADs.	dpag	79-83	brain-derived neurotrophic factor	Rattus norvegicus	55-59
25840741-11	2015	Altogether, our data suggests that facilitation of the BDNF-TRKB system in the DPAG is implicated in the panicolytic effect of ADs.	dpag	79-83	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	60-64