PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 34792016-0 2022 Dipsacoside B Exerts a Beneficial Effect on Brain Injury in the Ischemic Stroke Rat through Inhibition of Mitochondrial E3 Ubiquitin Ligase 1. dipsacoside B 0-13 mitochondrial E3 ubiquitin protein ligase 1 Rattus norvegicus 106-141 34792016-1 2022 BACKGROUND: Upregulation of mitochondrial E3 ubiquitin ligase 1 (Mul1) contributes to brain injury in ischemic stroke due to disturbance of mitochondrial dynamics, and bioinformatics analysis predicts that Mul1 is a potential target of Dipsacoside B. dipsacoside B 236-249 mitochondrial E3 ubiquitin protein ligase 1 Rattus norvegicus 28-63 34792016-1 2022 BACKGROUND: Upregulation of mitochondrial E3 ubiquitin ligase 1 (Mul1) contributes to brain injury in ischemic stroke due to disturbance of mitochondrial dynamics, and bioinformatics analysis predicts that Mul1 is a potential target of Dipsacoside B. dipsacoside B 236-249 mitochondrial E3 ubiquitin protein ligase 1 Rattus norvegicus 65-69 34792016-1 2022 BACKGROUND: Upregulation of mitochondrial E3 ubiquitin ligase 1 (Mul1) contributes to brain injury in ischemic stroke due to disturbance of mitochondrial dynamics, and bioinformatics analysis predicts that Mul1 is a potential target of Dipsacoside B. dipsacoside B 236-249 mitochondrial E3 ubiquitin protein ligase 1 Rattus norvegicus 206-210 34792016-2 2022 OBJECTIVE: The aim of the study was to explore whether Dipsacoside B can exert a beneficial effect on brain injury in the ischemic stroke rat via targeting Mul1. dipsacoside B 55-68 mitochondrial E3 ubiquitin protein ligase 1 Rattus norvegicus 156-160 32793668-0 2020 The role of Neu1 in the protective effect of dipsacoside B on acetaminophen-induced liver injury. dipsacoside B 45-58 neuraminidase 1 Mus musculus 12-16 32793668-17 2020 Conclusions: These data indicate that DB alleviated hepatotoxicity caused by APAP at least in part via Neu1 inhibition, Akt/mTOR pathway is involved in the detoxification effect of DB on acetaminophen-induced hepatotoxicity. dipsacoside B 38-40 neuraminidase 1 Mus musculus 103-107 32793668-17 2020 Conclusions: These data indicate that DB alleviated hepatotoxicity caused by APAP at least in part via Neu1 inhibition, Akt/mTOR pathway is involved in the detoxification effect of DB on acetaminophen-induced hepatotoxicity. dipsacoside B 38-40 mechanistic target of rapamycin kinase Mus musculus 124-128