PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
9065782-0	1997	Functional interaction of the carboxylic acid group of agonists and the arginine residue of the seventh transmembrane domain of prostaglandin E receptor EP3 subtype.	Carboxylic Acids	30-45	prostaglandin E receptor 3	Homo sapiens	153-156
9061203-1	1997	Representative examples of NSAID cyclooxygenase inhibitors such as naproxen, ibufenac, ibuprofen, and butibufen have been transformed into 5-lipoxygenase inhibitors by replacement of the carboxylic acid moiety with a 4-hydroxythiazole group.	Carboxylic Acids	187-202	arachidonate 5-lipoxygenase	Homo sapiens	139-153
8955368-6	1996	This common feature of cytochrome c and quinol oxidases indicates that at least (i) one redox-sensitive carboxyl group is in the protonated state in the oxidized form and (ii) one carboxylic acid is involved at a catalytic step--presumably in proton translocation--of haem-copper oxidase.	Carboxylic Acids	180-195	cytochrome c, somatic	Homo sapiens	23-35
9017218-1	1997	The catalytic site of all dihydrofolate reductases contains an invariant carboxylic acid, equivalent to Asp-27 in Escherichia coli dihydrofolate reductase (ecDHFR).	Carboxylic Acids	73-88	dihydrofolate reductase	Escherichia coli	156-162
8937481-0	1996	Inhibition of a medium chain acyl-CoA synthetase involved in glycine conjugation by carboxylic acids.	Carboxylic Acids	84-100	acyl-CoA synthetase medium chain family member 1	Homo sapiens	16-48
8937481-1	1996	Molecular characteristics of carboxylic acids were investigated for the ability to inhibit a purified medium chain acyl-CoA synthetase, using hexanoic acid as a substrate.	Carboxylic Acids	29-45	acyl-CoA synthetase medium chain family member 1	Homo sapiens	102-134
8937481-9	1996	In addition, there was a good correlation between the lipophilicity of the carboxylic acids and the Ki values, suggesting that the lipophilicity of the carboxylic acids is a major determinant for inhibition of the medium chain acyl-CoA synthetase.	Carboxylic Acids	75-91	acyl-CoA synthetase medium chain family member 1	Homo sapiens	214-246
8937481-9	1996	In addition, there was a good correlation between the lipophilicity of the carboxylic acids and the Ki values, suggesting that the lipophilicity of the carboxylic acids is a major determinant for inhibition of the medium chain acyl-CoA synthetase.	Carboxylic Acids	152-168	acyl-CoA synthetase medium chain family member 1	Homo sapiens	214-246
9019529-4	1996	Significant CCK-A receptor inhibitory activities were found in only two series, that is, sulfoxide-carboxylic acid derivatives (9) and sulfone-carboxylic acid derivatives (10).	Carboxylic Acids	99-114	cholecystokinin A receptor	Homo sapiens	12-26
8931944-9	1996	Consistent with previous reports, (S)-configuration at the substituted phenethylamide center, a carboxylic acid and the presence of a phenyl ring were found to be associated with increased affinity at both CCK-A and CCK-B receptors.	Carboxylic Acids	96-111	cholecystokinin A receptor	Homo sapiens	206-211
8931944-9	1996	Consistent with previous reports, (S)-configuration at the substituted phenethylamide center, a carboxylic acid and the presence of a phenyl ring were found to be associated with increased affinity at both CCK-A and CCK-B receptors.	Carboxylic Acids	96-111	cholecystokinin B receptor	Homo sapiens	216-221
8831266-4	1996	Significant CCK-A receptor inhibitory activities were found in sulfone-carboxylic acid derivatives (7) having very hydrophobic sidechains.	Carboxylic Acids	71-86	cholecystokinin A receptor	Homo sapiens	12-26
8710847-2	1996	Three different redox-active carboxylic acids were coupled to the side chain of cis-4-amino-L-proline.	Carboxylic Acids	29-45	suppressor of cytokine signaling 6	Homo sapiens	80-85
8764602-3	1996	Because PUT-SOD had the highest PS values, SOD was modified in the present experiments by activating carboxylic acid groups to the reactive ester with water-soluble carbodiimide and then reacted with PUT as the nucleophilic reagent.	Carboxylic Acids	101-116	superoxide dismutase 1	Homo sapiens	12-15
8764602-3	1996	Because PUT-SOD had the highest PS values, SOD was modified in the present experiments by activating carboxylic acid groups to the reactive ester with water-soluble carbodiimide and then reacted with PUT as the nucleophilic reagent.	Carboxylic Acids	101-116	superoxide dismutase 1	Homo sapiens	43-46
8764602-4	1996	Preservation of SOD enzyme activity while maximizing the permeability was accomplished by adjusting the ionization of the protein carboxylic acid with pH.	Carboxylic Acids	130-145	superoxide dismutase 1	Homo sapiens	16-19
9019529-4	1996	Significant CCK-A receptor inhibitory activities were found in only two series, that is, sulfoxide-carboxylic acid derivatives (9) and sulfone-carboxylic acid derivatives (10).	Carboxylic Acids	143-158	cholecystokinin A receptor	Homo sapiens	12-26
7493972-0	1995	Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety.	Carboxylic Acids	129-144	prostaglandin-endoperoxide synthase 1	Homo sapiens	16-44
8653989-1	1996	Losartan, a selective angiotensin II (AT1) receptor antagonist for hypertension, is metabolized to an active carboxylic acid metabolite, E-3174, which has a longer half-life.	Carboxylic Acids	109-124	angiotensin II receptor type 1	Homo sapiens	38-41
8666343-7	1996	Enhanced stability of mature PAI-1 transcript could not be demonstrated in Hep G2 cells treated with the carboxylic acid.	Carboxylic Acids	105-120	serpin family E member 1	Homo sapiens	29-34
7493972-2	1995	From the crystal structure of sheep PGHS-1, it has been proposed that the carboxylic acid group of flurbiprofen is located in a favorable position for interacting with the arginine 120 residue of PGHS-1 (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249).	Carboxylic Acids	74-89	prostaglandin G/H synthase 1	Ovis aries	36-42
7493972-2	1995	From the crystal structure of sheep PGHS-1, it has been proposed that the carboxylic acid group of flurbiprofen is located in a favorable position for interacting with the arginine 120 residue of PGHS-1 (Picot, D., Loll, P. J., and Garavito, R. M. (1994) Nature 367, 243-249).	Carboxylic Acids	74-89	prostaglandin G/H synthase 1	Ovis aries	196-202
7493972-10	1995	These data provide biochemical evidence of the importance of the Arg120 residue in PGHS-1 for interaction with arachidonic acid and NSAIDs containing a free carboxylic acid moiety.	Carboxylic Acids	157-172	prostaglandin-endoperoxide synthase 1	Homo sapiens	83-89
7547972-1	1995	The ability of Drosophila alcohol dehydrogenase (D-ADH) to catalyze the oxidation of aldehydes to carboxylic acids has been re-examined.	Carboxylic Acids	98-114	Alcohol dehydrogenase	Drosophila melanogaster	15-47
8591727-1	1995	The aim of this study was to identify the form(s) of cytochrome P450 (CYP) responsible for the biotransformation of zolpidem to its alcohol derivatives which, after rapid conversion to carboxylic acids, represents the main way of metabolism in humans.	Carboxylic Acids	185-201	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	53-68
8591727-1	1995	The aim of this study was to identify the form(s) of cytochrome P450 (CYP) responsible for the biotransformation of zolpidem to its alcohol derivatives which, after rapid conversion to carboxylic acids, represents the main way of metabolism in humans.	Carboxylic Acids	185-201	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	70-73
7547972-1	1995	The ability of Drosophila alcohol dehydrogenase (D-ADH) to catalyze the oxidation of aldehydes to carboxylic acids has been re-examined.	Carboxylic Acids	98-114	Alcohol dehydrogenase	Drosophila melanogaster	49-54
7650690-5	1995	In contrast to those retinoids selective for the RARs, these RXR-selective retinoids have one less atom in the bridge linking the hydrophobic and carboxylic acid termini of the retinoid skeleton.	Carboxylic Acids	146-161	retinoid X receptor alpha	Homo sapiens	61-64
7654690-8	1995	In fact, the four new substrates of CYP2C9 described in this study, a carboxylic acid, phenol, and tetrazole derivative, each of which is related to tienilic acid, and the antiinflammatory drug, suprofen (with Km between 12 and 130 microM and kcat between 0.2 and 1.3 min-1), as well as almost all CYP2C9 substrates reported in the literature, exhibit a pKa below 7 (except phenytoin whose pKa is 8.1).	Carboxylic Acids	70-85	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	36-42
7654690-8	1995	In fact, the four new substrates of CYP2C9 described in this study, a carboxylic acid, phenol, and tetrazole derivative, each of which is related to tienilic acid, and the antiinflammatory drug, suprofen (with Km between 12 and 130 microM and kcat between 0.2 and 1.3 min-1), as well as almost all CYP2C9 substrates reported in the literature, exhibit a pKa below 7 (except phenytoin whose pKa is 8.1).	Carboxylic Acids	70-85	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	298-304
7736913-9	1995	It was then demonstrated that microsomes containing either recombinant human liver CYP2C9 or CYP3A4 were capable of oxidizing both losartan and the aldehyde E3179 to the carboxylic acid E3174.	Carboxylic Acids	170-185	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	83-89
7648404-9	1995	This quinoline-carboxylic acid derivative is a potent inhibitor of DHOdehase and has proven anti-proliferative activity.	Carboxylic Acids	15-30	dihydroorotate dehydrogenase (quinone)	Rattus norvegicus	67-76
7872797-0	1995	Probing the active sites of rat and human cytochrome P450 2E1 with alcohols and carboxylic acids.	Carboxylic Acids	80-96	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	42-61
7542927-15	1995	The idea that there is a site in the vasopressin-stimulated lanthanide-sensitive Ca2+ channel composed of carboxylic acid groups which bind Ca2+, Mn2+ or a lanthanide ion is consistent with the data obtained using the different lanthanides.	Carboxylic Acids	106-121	arginine vasopressin	Homo sapiens	37-48
7582974-4	1995	Possible LTA4 binding modes in the active site of LTA4 hydrolase, including a possible direct role for the carboxylic acid of LTA4 in the enzyme-catalyzed hydrolysis of leukotriene A4, are discussed.	Carboxylic Acids	107-122	leukotriene A4 hydrolase	Homo sapiens	50-64
7718556-4	1995	CD spectra and two-dimensional NMR experiments were performed to investigate the KR-ET-1 three-dimensional structure in water in the carboxylic acid and carboxylate states.	Carboxylic Acids	133-148	endothelin 1	Homo sapiens	84-88
7718556-6	1995	The KR-ET-1 carboxylic acid conformation was found to be very similar to ET-1, with a helix spanning residues 9-15 and an unconstrained C-terminal part.	Carboxylic Acids	12-27	endothelin 1	Homo sapiens	7-11
7736913-9	1995	It was then demonstrated that microsomes containing either recombinant human liver CYP2C9 or CYP3A4 were capable of oxidizing both losartan and the aldehyde E3179 to the carboxylic acid E3174.	Carboxylic Acids	170-185	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	93-99
7736922-7	1995	In a reconstituted system, P450 MUT-2 (CYP2C29) purified from mouse hepatic microsomes catalyzed the oxidation of o-, m-, and p-tolualdehydes to the carboxylic acids, and the specific activities (nmol/min/nmol P450) were 1.44, 2.81, and 2.32, respectively.	Carboxylic Acids	149-165	mutator 2	Mus musculus	32-37
7736922-7	1995	In a reconstituted system, P450 MUT-2 (CYP2C29) purified from mouse hepatic microsomes catalyzed the oxidation of o-, m-, and p-tolualdehydes to the carboxylic acids, and the specific activities (nmol/min/nmol P450) were 1.44, 2.81, and 2.32, respectively.	Carboxylic Acids	149-165	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	39-46
7916209-6	1994	A positive band at 1712 cm-1 caused by the protonation of an internal carboxylic acid in rhodopsin was shifted slightly to 1709 cm-1 in mutant E113D.	Carboxylic Acids	70-85	rhodopsin	Bos taurus	89-98
8612047-2	1995	The oxidative decarboxylation of carboxylic acids by the chemical cytochrome P-450 model and rat liver microsomal systems was investigated.	Carboxylic Acids	33-49	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	66-82
7895165-3	1994	In vitro, CLIP dissociation from DR alpha beta dimers occurs at different rates depending on the allele, and is facilitated by low pH and by detergents containing 8-10 carbon unbranched hydrocarbons, or by primary aliphatic amines or carboxylic acids.	Carboxylic Acids	234-250	CAP-Gly domain containing linker protein 1	Homo sapiens	10-14
7895165-3	1994	In vitro, CLIP dissociation from DR alpha beta dimers occurs at different rates depending on the allele, and is facilitated by low pH and by detergents containing 8-10 carbon unbranched hydrocarbons, or by primary aliphatic amines or carboxylic acids.	Carboxylic Acids	234-250	solute carrier family 26 member 3	Homo sapiens	33-41
7929034-0	1994	A conserved carboxylic acid group mediates light-dependent proton uptake and signaling by rhodopsin.	Carboxylic Acids	12-27	rhodopsin	Homo sapiens	90-99
8142254-4	1994	P1 and P10 were later shown by chemical and mass spectral studies to be carboxylic acids.	Carboxylic Acids	72-88	S100 calcium binding protein A10	Homo sapiens	7-10
8078928-4	1994	Sterol 27-hydroxylase has the unusual ability to hydroxylate the same methyl group three times to give a carboxylic acid; thus, 3 beta-hydroxy-5-cholestenoic acid is likely to be a direct product of the enzyme.	Carboxylic Acids	105-120	cytochrome P450 family 27 subfamily A member 1	Homo sapiens	0-21
8068654-4	1994	The Schiff base positive charge in rhodopsin is stabilized by a carboxylic acid counterion, Glu113.	Carboxylic Acids	64-79	rhodopsin	Homo sapiens	35-44
7956738-6	1994	The urinary metabolites resulted from hydroxylation at the C-7 methyl group at C-8 and C-9 in the isopropyl moiety, resulting in a series of mono- and dihydroxy-menthols and carboxylic acids, some of which are excreted in part as glucuronic acid conjugates.	Carboxylic Acids	174-190	complement C9	Rattus norvegicus	79-90
7945717-1	1994	Some carboxylic acids of N(3)-pyrazole substituted 1,2,3-benzotriazin-4-(3H)-ones and- quinazolin-4-(3H)-ones were prepared and tested for the inhibitory property of 3 alpha-hydroxysteroid dehydrogenase of rat liver cytosol.	Carboxylic Acids	5-21	aldo-keto reductase family 1, member C14	Rattus norvegicus	166-202
8308869-0	1994	Selective protection and relative importance of the carboxylic acid groups of zaragozic acid A for squalene synthase inhibition.	Carboxylic Acids	52-67	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	99-116
8308869-1	1994	Chemistry that allows selective modification of the carboxylic acid groups of the squalene synthase inhibitor zaragozic acid A (1) was developed and applied to the synthesis of compounds modified at the 3-,4-,5-,3,4-,3,5-, and 4,5-positions.	Carboxylic Acids	52-67	farnesyl diphosphate farnesyl transferase 1	Rattus norvegicus	82-99
7787879-4	1994	TRP2 functions as DOPAchrome tautomerase, an enzyme that preserves the carboxylic acid content of melanins, which would be spontaneously lost in its absence, while TRP1 is able to oxidize the DHICA produced by TRP2.	Carboxylic Acids	71-86	tRNA proline 2	Mus musculus	0-4
7787879-4	1994	TRP2 functions as DOPAchrome tautomerase, an enzyme that preserves the carboxylic acid content of melanins, which would be spontaneously lost in its absence, while TRP1 is able to oxidize the DHICA produced by TRP2.	Carboxylic Acids	71-86	dopachrome tautomerase	Mus musculus	18-40
7787879-4	1994	TRP2 functions as DOPAchrome tautomerase, an enzyme that preserves the carboxylic acid content of melanins, which would be spontaneously lost in its absence, while TRP1 is able to oxidize the DHICA produced by TRP2.	Carboxylic Acids	71-86	tRNA proline 2	Mus musculus	210-214
7901852-0	1993	Protonation states of membrane-embedded carboxylic acid groups in rhodopsin and metarhodopsin II: a Fourier-transform infrared spectroscopy study of site-directed mutants.	Carboxylic Acids	40-55	rhodopsin	Bos taurus	66-75
8302279-0	1994	A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.	Carboxylic Acids	196-212	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	48-75
8302279-0	1994	A recombinant phenobarbital-inducible rat liver UDP-glucuronosyltransferase (UDP-glucuronosyltransferase 2B1) stably expressed in V79 cells catalyzes the glucuronidation of morphine, phenols, and carboxylic acids.	Carboxylic Acids	196-212	UDP glucuronosyltransferase family 2 member B17	Rattus norvegicus	77-108
8312678-2	1993	Epalrestat is a carboxylic acid derivative which inhibits aldose reductase, an enzyme of the sorbitol (polyol) pathway.	Carboxylic Acids	16-31	aldo-keto reductase family 1 member B	Homo sapiens	58-74
8399169-3	1993	Two bands assigned to the C = O stretching mode of Asp and/or Glu carboxylic acid groups are absent in the D83N rhodopsin-->metarhodopsin II FTIR difference spectrum.	Carboxylic Acids	66-81	rhodopsin	Homo sapiens	112-121
8214591-1	1993	A fast and reliable method for the assay of UDP-glucuronosyltransferase (UGT) activity toward aglycones containing a carboxylic acid function is described.	Carboxylic Acids	117-132	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	44-71
8214591-1	1993	A fast and reliable method for the assay of UDP-glucuronosyltransferase (UGT) activity toward aglycones containing a carboxylic acid function is described.	Carboxylic Acids	117-132	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	73-76
8214591-3	1993	The technique was validated for each of the seven substrates tested by reversed-phase HPLC, and was then applied successfully to the determination of optimal conditions for the activation of the carboxylic acid-UGT, and the estimation of kinetic constants for the glucuronidation of clofibric acid, 2-naphthylacetic acid, naproxen, and 4,4,4-triphenylbutanoic acid in rat liver microsomes.	Carboxylic Acids	195-210	UDP glycosyltransferase 2 family, polypeptide B	Rattus norvegicus	211-214
8343512-0	1993	Regulation of the rhodopsin-transducin interaction by a highly conserved carboxylic acid group.	Carboxylic Acids	73-88	rhodopsin	Homo sapiens	18-27
8444840-1	1993	The environment of the retinylidene Schiff base in bovine rhodopsin has been studied by movement of its carboxylic acid counterion from position 113 to position 117 by site-specific mutagenesis.	Carboxylic Acids	104-119	rhodopsin	Bos taurus	58-67
8327562-3	1993	The compounds D/1, D/2 and E/1-E/5 were hydrolyzed to give the corresponding carboxylic acids.	Carboxylic Acids	77-93	leiomodin 1	Homo sapiens	14-34
8387599-3	1993	An exploration of stereochemistry indicates that the configuration of the carboxylic acids and the ring fusion in the inhibitors is important for potent cGMP PDE inhibition.	Carboxylic Acids	74-90	aldehyde dehydrogenase 7 family member A1	Homo sapiens	158-161
8423545-0	1993	Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs.	Carboxylic Acids	136-151	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	76-119
8096720-1	1993	D-Glucaro(1,4)lactone, a potent beta-glucuronidase inhibitor was attached via the carboxylic acid moiety to polyvinylbenzyl chloride (PVBC) using a bimolecular nucleophilic displacement reaction.	Carboxylic Acids	82-97	glucuronidase beta	Homo sapiens	32-50
8423545-5	1993	Two other carboxylic acid-containing drugs (clofibric acid and valproic acid) and a limited range of drugs containing an alcohol or phenolic functional group were also glucoronidated by expressed UGT2B7 variant.	Carboxylic Acids	10-25	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	196-202
1362946-3	1992	We have determined that rat hepatic alcohol dehydrogenase and aldehyde dehydrogenase are responsible for this biotransformation through sequential oxidation of the alcohol through the aldehyde to the carboxylic acid.	Carboxylic Acids	200-215	aldo-keto reductase family 1 member A1	Rattus norvegicus	36-57
1361949-4	1992	Since B13 is always a carboxylic acid in all known sequences of hexamer forming insulins, it is likely to be important in the hormone"s biology.	Carboxylic Acids	22-37	NADH:ubiquinone oxidoreductase subunit A5	Homo sapiens	6-9
1290616-12	1992	The key to the discovery of nonpeptide AII-receptor antagonists with improved oral activity and duration of action resulted from replacing the carboxylic acid group with the isosteric but more lipophilic tetrazole ring.	Carboxylic Acids	143-158	angiotensinogen	Homo sapiens	39-42
1304173-4	1992	By substituting carboxylic acids for axial glycines in the translated proteins both mutations would be expected to disrupt the secondary structure of the collagenous triple helix of the 96 kDa MBP subunits.	Carboxylic Acids	16-32	myelin basic protein	Homo sapiens	193-196
1417834-0	1992	Mouse hepatic microsomal oxidation of aliphatic aldehydes (C8 to C11) to carboxylic acids.	Carboxylic Acids	73-89	polymerase (RNA) III (DNA directed) polypeptide K	Mus musculus	65-68
1329948-1	1992	Rhodopsin and all of the vertebrate visual pigments have a carboxylic acid residue, Glu113, in the third transmembrane segment that serves as a counterion to the protonated Schiff base nitrogen of the chromophore.	Carboxylic Acids	59-74	rhodopsin	Bos taurus	0-9
1417834-1	1992	Addition of saturated and alpha, beta-unsaturated aliphatic aldehydes (C8 to C11) significantly increased NADPH oxidation with mouse hepatic microsomes, and the aldehydes themselves were oxidized to the corresponding carboxylic acids.	Carboxylic Acids	217-233	polymerase (RNA) III (DNA directed) polypeptide K	Mus musculus	77-80
1324315-7	1992	A metabolically stable LTA4 hydrolase inhibitor, RP64966, was obtained by insertion of an oxygen atom in the beta-position on the carboxylic acid side chain.	Carboxylic Acids	130-145	leukotriene A4 hydrolase	Rattus norvegicus	23-37
1516710-9	1992	It is thus proposed that either a glutamic or glutamine moiety at 297 is required for full LTA4 hydrolase activity, while the free carboxylic acid of glutamic acid is essential for aminopeptidase.	Carboxylic Acids	131-146	carboxypeptidase Q	Homo sapiens	181-195
1812067-5	1991	In the RNase T1-GpC complex, the 2"-OH group is in close proximity to the side chain carboxylic acid of Glu58 which leads to the formation of a hydrogen bond.	Carboxylic Acids	85-100	glycophorin C (Gerbich blood group)	Homo sapiens	16-19
1635058-4	1992	Several of the compounds have CCK-B binding affinities similar to the parent carboxylic acid 1 (CCK-B, IC50 = 1.7 nM; pK(a) = 5.6) and span a pK(a) range of less than 1 (sulfonic acid 27) to greater than 9.5 (5-thio-1,2,4-triazole 24).	Carboxylic Acids	77-92	cholecystokinin B receptor	Homo sapiens	30-35
1635058-4	1992	Several of the compounds have CCK-B binding affinities similar to the parent carboxylic acid 1 (CCK-B, IC50 = 1.7 nM; pK(a) = 5.6) and span a pK(a) range of less than 1 (sulfonic acid 27) to greater than 9.5 (5-thio-1,2,4-triazole 24).	Carboxylic Acids	77-92	cholecystokinin B receptor	Homo sapiens	96-101
1615843-3	1992	All but one of the new ACE inhibitors are carboxylic-acid compounds, and all of them maintain a pro-drug metabolic pathway.	Carboxylic Acids	42-57	angiotensin I converting enzyme	Homo sapiens	23-26
1312603-4	1992	The dichloronigericinol 7 impressively demonstrated that the C-1 carboxylic acid moiety was not required for a distinct activity against bacteria and viruses.	Carboxylic Acids	65-80	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	61-64
1713710-1	1991	The 2.05 angstrom (A) resolution crystal structure of a dodecasaccharide-Fab complex revealed an unusual carbohydrate recognition site, defined by aromatic amino acids and a structured water molecule, rather than the carboxylic acid and amide side chains and a structured water molecule, rather than the carboxylic acid and amide side chains that are features of transport and other carbohydrate binding proteins.	Carboxylic Acids	217-232	FA complementation group B	Homo sapiens	73-76
1713710-1	1991	The 2.05 angstrom (A) resolution crystal structure of a dodecasaccharide-Fab complex revealed an unusual carbohydrate recognition site, defined by aromatic amino acids and a structured water molecule, rather than the carboxylic acid and amide side chains and a structured water molecule, rather than the carboxylic acid and amide side chains that are features of transport and other carbohydrate binding proteins.	Carboxylic Acids	304-319	FA complementation group B	Homo sapiens	73-76
1655922-0	1991	[MALDO (microsomal aldehyde oxygenase): a cytochrome P-450 isozyme purified from mouse hepatic microsomes that catalyzes the oxygenation of aldehyde to carboxylic acid].	Carboxylic Acids	152-167	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	19-37
1676667-4	1991	Although none of the carboxylic acids tested were substrates for AST IV, they did competitively inhibit the enzyme with 1-naphthalenemethanol as substrate at pH 7.0.	Carboxylic Acids	21-37	sulfotransferase family 1A member 1	Rattus norvegicus	65-71
1850743-3	1991	Comparison of these values with those for model compounds indicates that KH1 and KH2 refer to equilibria involving the beta-diketone and carboxylic acid moieties, respectively.	Carboxylic Acids	137-152	potassium voltage-gated channel modifier subfamily F member 1	Homo sapiens	73-76
1850743-3	1991	Comparison of these values with those for model compounds indicates that KH1 and KH2 refer to equilibria involving the beta-diketone and carboxylic acid moieties, respectively.	Carboxylic Acids	137-152	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	81-84
2050688-11	1991	These results support the role of a carboxylic acid residue at position 302 in the catalytic activity of cytochrome P-450AROM.	Carboxylic Acids	36-51	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	105-125
1768424-3	1991	We show that [3H]CD-270 carboxylic acid binds specifically to CRABP, whereas the alcohol derivative binds strongly to CRBP.	Carboxylic Acids	24-39	TNF receptor superfamily member 14	Homo sapiens	17-23
1847130-0	1991	Oxygenation mechanism in conversion of aldehyde to carboxylic acid catalyzed by a cytochrome P-450 isozyme.	Carboxylic Acids	51-66	cytochrome P450, family 21, subfamily a, polypeptide 1	Mus musculus	82-98
1847130-1	1991	The oxygenation of an aldehyde, 11-oxo-delta 8-tetrahydrocannabinol to a carboxylic acid, delta 8-tetrahydrocannabinol-11-oic acid was catalyzed by cytochrome P-450 MUT-2 purified from hepatic microsomes of male ddN mice.	Carboxylic Acids	73-88	cytochrome P450, family 2, subfamily c, polypeptide 29	Mus musculus	148-170
16668043-8	1991	The partially purified H(+)-ATPase also showed sensitivity to the NCD-4, supporting the hypothesis that this carboxylic acid reagent is an inhibitor of the tonoplast ATPase from maize roots.	Carboxylic Acids	109-124	ATPase	Zea mays	28-34
16668043-8	1991	The partially purified H(+)-ATPase also showed sensitivity to the NCD-4, supporting the hypothesis that this carboxylic acid reagent is an inhibitor of the tonoplast ATPase from maize roots.	Carboxylic Acids	109-124	ATPase	Zea mays	166-172
1804048-0	1991	Effects of some lipophilic carboxylic acid on release of interferon gamma from the human peripheral blood leukocytes.	Carboxylic Acids	27-42	interferon gamma	Homo sapiens	57-73
1768424-3	1991	We show that [3H]CD-270 carboxylic acid binds specifically to CRABP, whereas the alcohol derivative binds strongly to CRBP.	Carboxylic Acids	24-39	cellular retinoic acid binding protein 1	Homo sapiens	62-67
1768424-4	1991	However, the low amount of CRABP present concomitantly with CRBP suggests that [3H]CD-270 alcohol might be oxidized into minute amounts of the corresponding carboxylic acid derivative.	Carboxylic Acids	157-172	retinol binding protein 1	Homo sapiens	60-64
1768424-4	1991	However, the low amount of CRABP present concomitantly with CRBP suggests that [3H]CD-270 alcohol might be oxidized into minute amounts of the corresponding carboxylic acid derivative.	Carboxylic Acids	157-172	TNF receptor superfamily member 14	Homo sapiens	83-89
2224187-1	1990	Simvastatin, a pro-drug lactone, forms the open carboxylic acid as a major metabolite that inhibits the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase.	Carboxylic Acids	48-63	3-hydroxy-3-methylglutaryl-CoA reductase	Homo sapiens	116-163
34913236-2	2022	Mixed anhydrides of carboxylic acids were prepared using isobutyl chloroformate and transformed to the corresponding KATs using a commercial copper catalyst, B 2 (pin) 2 and aqueous KHF 2 .	Carboxylic Acids	20-36	telomeric repeat binding factor 1	Homo sapiens	158-169
33778252-4	2021	The sensor array is composed of pH indicators and aniline dyes from classical spot tests, which enabled molecular recognition of a variety of aldehydes, ketones, and carboxylic acids as demonstrated by hierarchical clustering and principal component analyses.	Carboxylic Acids	166-182	phenylalanine hydroxylase	Homo sapiens	32-34
19138732-3	2009	In the copolymers permeability of B12 is controlled by both intramolecular and intermolecular hydrogen-bonding between the pyrrolidinone and carboxylic acid side chains.	Carboxylic Acids	141-156	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	34-37
2105083-5	1990	Analysis with Fourier transform infrared (FTIR)-photoacoustic spectroscopy demonstrated the presence of a new structure in the calmodulin molecule consistent with modification of carboxylic acid groups.	Carboxylic Acids	179-194	calmodulin 1	Homo sapiens	127-137
34710447-5	2022	Moreover, the XPS and ATR-FTIR results elucidated that the oxidation patterns under the exposure conditions followed from ketone/aldehyde formation to carboxylate groups (carboxylic acid/ester).	Carboxylic Acids	171-186	ATR serine/threonine kinase	Homo sapiens	22-25
34175538-0	2021	Non-carboxylic acid inhibitors of aldose reductase based on N-substituted thiazolidinedione derivatives.	Carboxylic Acids	4-19	aldo-keto reductase family 1 member B	Homo sapiens	34-50
34686102-4	2022	This dendrimer was formed by activating the carboxylic acid groups of DOTA-folic acid and bombesin with HATU and conjugating them to develop the dendrimer.	Carboxylic Acids	44-59	gastrin releasing peptide	Homo sapiens	90-98
34669980-0	2021	The Formal Cross-Coupling of Amines and Carboxylic Acids to Form sp3-sp3 Carbon-Carbon Bonds.	Carboxylic Acids	40-56	Sp3 transcription factor	Homo sapiens	65-68
34669980-0	2021	The Formal Cross-Coupling of Amines and Carboxylic Acids to Form sp3-sp3 Carbon-Carbon Bonds.	Carboxylic Acids	40-56	Sp3 transcription factor	Homo sapiens	69-72
34669980-1	2021	We have developed a deaminative-decarboxylative protocol to form sp3-sp3 carbon-carbon bonds from activated amines and carboxylic acids.	Carboxylic Acids	119-135	Sp3 transcription factor	Homo sapiens	65-68
34669980-1	2021	We have developed a deaminative-decarboxylative protocol to form sp3-sp3 carbon-carbon bonds from activated amines and carboxylic acids.	Carboxylic Acids	119-135	Sp3 transcription factor	Homo sapiens	69-72
34711686-6	2021	The present study determined that attractive carboxylic acids were mediated by broadly expressed Ir25a and Ir76b, as demonstrated by a candidate mutant library screen.	Carboxylic Acids	45-61	Ionotropic receptor 25a	Drosophila melanogaster	97-102
34711686-6	2021	The present study determined that attractive carboxylic acids were mediated by broadly expressed Ir25a and Ir76b, as demonstrated by a candidate mutant library screen.	Carboxylic Acids	45-61	Ionotropic receptor 76b	Drosophila melanogaster	107-112
34855394-0	2021	Finely Tuning Tridentate Carboxylic Acids for the Construction of Rod Scandium Metal-Organic Frameworks with High Chemical Stability and Selective Gas Adsorption.	Carboxylic Acids	25-41	gastrin	Homo sapiens	147-150
34855394-1	2021	By systematic ligand tuning for control of the secondary building units, the use of tridentate carboxylic acid to construct the rod scandium metal-organic framework NTUniv-55 (NTUniv = Nantong University) with high chemical stability and interesting selective gas adsorption was reported.	Carboxylic Acids	95-110	gastrin	Homo sapiens	260-263
34547831-4	2021	The designed dendrimeric platform was built with potential zinc-binding branching linkers (hydrazides) and termini (carboxylic acids and hydrazides) to confer potency against MMP-2/9.	Carboxylic Acids	116-132	matrix metallopeptidase 2	Homo sapiens	175-182
34904522-2	2022	One of the major in vivo metabolic pathways of vixotrigine in humans is the hydrolysis of the carboxamide to form the carboxylic acid metabolite M14.The in vitro formation of M14 in human hepatocytes was inhibited by the carboxylesterase (CES) inhibitor Bis(4-nitrophenyl) phosphate in a concentration-dependent manner.	Carboxylic Acids	118-133	carboxylesterase 1	Homo sapiens	221-237
34862252-10	2021	The major metabolic pathway was carboxylic acid glucuronidation, which was catalyzed predominantly by UGT2B7.	Carboxylic Acids	32-47	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	102-108
34619665-3	2021	Importantly, the reconstruction process relies on the esterification reaction between the organic solvent, i.e. ethanol and the carboxylic acid ligand, allowing the conversion of MOF without the addition of any other modulators and/or surfactants.	Carboxylic Acids	128-143	lysine acetyltransferase 8	Homo sapiens	179-182
34492763-0	2021	Probing the Ligand Exchange of N-Heterocyclic Carbene-Capped Ag2S Nanocrystals with Amines and Carboxylic Acids.	Carboxylic Acids	95-111	angiotensin II receptor type 1	Homo sapiens	61-65
34610632-1	2021	A novel peak-fitting assisted SERS (PF-SERS) strategy was developed for the first time to discriminate carboxylic acid enantiomers.	Carboxylic Acids	103-118	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	36-43
34581584-0	2021	Discovery and Optimization of Orally Bioavailable Phthalazone and Cinnolone Carboxylic Acid Derivatives as S1P2 Antagonists against Fibrotic Diseases.	Carboxylic Acids	76-91	sphingosine-1-phosphate receptor 2	Mus musculus	107-111
34405935-3	2021	Herein, an alternative to the asymmetric Kharasch-Sosnovsky reaction that utilized a chiral copper catalyst and purple-LED irradiation to enable the three-component coupling of 1,3-dienes, oxime esters, and carboxylic acids is reported.	Carboxylic Acids	207-223	small integral membrane protein 10 like 2A	Homo sapiens	119-122
34614030-4	2021	The sensor array itself is composed of pH indicators and aniline dyes that enable molecular recognition of carboxylic acids, amines and carbonyl-containing compounds.	Carboxylic Acids	107-123	phenylalanine hydroxylase	Homo sapiens	39-41
34612356-1	2021	CpxM(iii)-catalyzed enantioselective C-H functionalization reactions have progressed rapidly using either chiral cyclopentadienyl ligands or appropriate chiral carboxylic acids.	Carboxylic Acids	160-176	carboxypeptidase X, M14 family member 1	Homo sapiens	0-4
34612356-3	2021	In this review, we highlight the developments in CpxM(iii)-catalyzed enantioselective C-H functionalization reactions through migratory insertion of metal-carbenes/nitrenes by employing chiral CpxM(iii) complexes or achiral CpxM(iii) complexes combined with chiral carboxylic acids.	Carboxylic Acids	265-281	carboxypeptidase X, M14 family member 1	Homo sapiens	49-53
34492763-3	2021	Herein, solution 1H nuclear magnetic resonance methods were used to monitor ligand exchange reactions on stoichiometric Ag2S nanocrystal platforms with various primary amine and carboxylic acid ligands.	Carboxylic Acids	178-193	angiotensin II receptor type 1	Homo sapiens	120-124
34183377-3	2021	The human enzyme hAOX1 is characterized by a broad substrate specificity, oxidizing aromatic/aliphatic aldehydes into their corresponding carboxylic acids and hydroxylating various heteroaromatic rings.	Carboxylic Acids	138-154	aldehyde oxidase 1	Homo sapiens	17-22
34440262-7	2021	Furthermore, the GO enrichment analysis showed that fatty acid, monocarboxylic acid, carboxylic acid metabolic processes, negative regulation of neutrophil migration, and negative regulation of granulocyte and neutrophil chemotaxis were significantly enriched by ROR2 dysregulation.	Carboxylic Acids	85-100	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	263-267
34427396-10	2022	Our data suggest that HarmIR8a is important for H. armigera to detect short-chain carboxylic acids and mediate attraction behavior to acetic acid.	Carboxylic Acids	82-98	Ionotropic receptor 8a	Drosophila melanogaster	22-30
34369755-7	2021	We also used a systematic series of increasingly larger alkyl adenosine esters as chemical probes to characterize the structural basis of the exquisite ACS specificity for acetate over larger carboxylic acid substrates.	Carboxylic Acids	192-207	acyl-CoA synthetase short chain family member 2	Homo sapiens	152-155
35312238-7	2022	Without any additions, the mold was heated and the material transformed into a thermoset by reaction of the two carboxylic acid-derivatives of AdA and KL in the second step.	Carboxylic Acids	112-127	klotho	Homo sapiens	151-153
34170107-11	2021	It was found that the migratory behavior of CD4+ TEM cells carrying carboxylic acid-, biotin-, or Wheat germ agglutinin (WGA)-functionalized nanoparticles was not affected by the presence of the nanoparticle payload.	Carboxylic Acids	68-83	CD4 molecule	Homo sapiens	44-47
34143495-7	2021	Relaxin-2 significantly modified the hepatic levels of 19 glycerophospholipids, 2 saturated (SFA) and 1 monounsaturated (MUFA) fatty acids (FA), 3 diglycerides, 1 sphingomyelin, 2 aminoacids, 5 nucleosides, 2 nucleotides, 1 carboxylic acid, 1 redox electron carrier, and 1 vitamin.	Carboxylic Acids	224-239	relaxin 2	Homo sapiens	0-9
34193668-9	2021	The ionization of the carboxylic acid groups in the bola-type amphiphilic molecule with increasing pH is disadvantageous for micelle formation.	Carboxylic Acids	22-37	phenylalanine hydroxylase	Homo sapiens	99-101
34133080-0	2021	Crystal Phase Effects on the Gas-Phase Ketonization of Small Carboxylic Acids over TiO2 Catalysts.	Carboxylic Acids	61-77	gastrin	Homo sapiens	29-32
34205541-3	2021	Magnetic immunoconjugates built on the surface of carboxylic acid-microsized magnetic particles (HOOC-MBs) were used to selectively capture ST2.	Carboxylic Acids	50-65	ST2	Homo sapiens	140-143
34071735-8	2021	Docking calculations revealed that they reach the amino acid residues present in the distal cavity of the MPO active site, where both the amino and carboxylic acid groups of the alpha-aminopropenoic acid arm are structural requirements for anchoring.	Carboxylic Acids	148-163	myeloperoxidase	Homo sapiens	106-109
34093433-4	2021	The results revealed that several new categories of molecules, such as "fatty acyls" and "carboxylic acids and derivatives", could be released through osteocytic Cx43 channels.	Carboxylic Acids	90-106	gap junction protein, alpha 3	Mus musculus	162-166
34163646-3	2021	The axially chiral styrene-type carboxylic acids produced have been successfully applied to Cp*CoIII-catalyzed asymmetric C-H activation reactions, indicating their potential as chiral ligands or catalysts in asymmetric synthesis.	Carboxylic Acids	32-48	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	95-100
34471049-5	2021	Its carboxylic acid was attached to four amino acids (Ser289/His323/His449/Thr473), which contributes to the stabilization of Activating Function-2 helix 12, and its phenylpyrrole moiety was rotated 121.8 degrees in PPARgamma-LBD from that in PPARalpha-LBD to interact with Phe264.	Carboxylic Acids	4-19	peroxisome proliferator activated receptor gamma	Homo sapiens	216-225
34471049-5	2021	Its carboxylic acid was attached to four amino acids (Ser289/His323/His449/Thr473), which contributes to the stabilization of Activating Function-2 helix 12, and its phenylpyrrole moiety was rotated 121.8 degrees in PPARgamma-LBD from that in PPARalpha-LBD to interact with Phe264.	Carboxylic Acids	4-19	peroxisome proliferator activated receptor alpha	Homo sapiens	243-252
34471049-6	2021	PPARdelta-LBD has the consensus four amino acids (Thr253/His287/His413/Tyr437) towards the carboxylic acids of its ligands, but it seems to lack sufficient space to accept saroglitazar because of the steric hindrance between the Trp228 or Arg248 residue of PPARdelta-LBD and its methylthiophenyl moiety.	Carboxylic Acids	91-107	peroxisome proliferator activated receptor delta	Homo sapiens	0-9
35551933-2	2022	As an efficient ligand for Co2+, ethylenediaminetetraacetic acid (EDTA) was introduced on the surface of porous PAN nanofibers with the aid of a branched polyethyleneimine (PEI) linker to obtain an adsorbent with carboxylic acid groups.	Carboxylic Acids	213-228	complement C2	Homo sapiens	27-30
35551933-3	2022	On the adsorbent surface, the carboxylic acid and amine groups from EDTA could adsorb Co2+ via ion exchange and chelation, and amine groups from PEI that remained after EDTA functionalization played a role in coordinating Co2+.	Carboxylic Acids	30-45	complement C2	Homo sapiens	86-89
35551933-3	2022	On the adsorbent surface, the carboxylic acid and amine groups from EDTA could adsorb Co2+ via ion exchange and chelation, and amine groups from PEI that remained after EDTA functionalization played a role in coordinating Co2+.	Carboxylic Acids	30-45	complement C2	Homo sapiens	222-225
35551933-4	2022	The amine and carboxylic acid groups were simultaneously involved in the adsorption on the surface, making it possible to remove Co2+ over a wide pH range.	Carboxylic Acids	14-29	complement C2	Homo sapiens	129-132
35147261-2	2022	It was found that the influence of the CF2 moiety on the acidity/basicity of the corresponding carboxylic acids and amines was defined by inductive the effect of the fluorine atoms and was nearly the same for acyclic and cyclic aliphatic compounds.	Carboxylic Acids	95-111	ATPase H+ transporting accessory protein 1	Homo sapiens	39-42
35366497-4	2022	Mechanism of pH sensitive flocculation is based in protonation first of phenolic groups and later of carboxylic acid groups in the HAs molecules, resulting in a reduction of Zeta potential value.	Carboxylic Acids	101-116	phenylalanine hydroxylase	Homo sapiens	13-15
35536635-3	2022	As the key additive, the inorganic salt ZnF2 mildly reacts with carboxylic acid at a high temperature and in situ generates HF, which eliminates surface oxide impurities, thus facilitating epitaxial shell growth.	Carboxylic Acids	64-79	zinc finger protein 2	Homo sapiens	40-44
35299278-0	2022	Investigation of Carboxylic Acid Isosteres and Prodrugs for Inhibition of the Human SIRT5 Lysine Deacylase Enzyme.	Carboxylic Acids	17-32	sirtuin 5	Homo sapiens	84-89
35359496-1	2022	Autoinducing peptides I and IV (AIP-I/IV) are naturally occurring cyclic thiodepsipeptides (CTPs) bearing a Ser-Thr-Cys-Asp/Tyr (STC(D/Y)) tetrapeptide motif, where the Cys thiol (HSC) in the side-chain is linked to the Met C-terminal carboxylic acid (MCOOH) to form 5-residue macrothiolactones,-SC(D/Y)FIMCO-.	Carboxylic Acids	235-250	stanniocalcin 1	Homo sapiens	129-132
35039813-1	2022	Using a carboxylic acid linker, this work achieved the epitaxially coordinated assembly of a Ag-S layer into a three-dimensional semi-conductive framework, with high thermal stability, as well as an interesting temperature-dependent luminescence response.	Carboxylic Acids	8-23	jagged canonical Notch ligand 1	Homo sapiens	93-97
35001550-2	2022	Perylenebisimide (PBI) chromophore tagged fluorescent ABC-triblock polycaprolactone (PCL) nanoscaffold was engineered having carboxylic acid blocks for the chemical conjugation of cisplatin at the core and hydrophilic PEG blocks at the periphery.	Carboxylic Acids	125-140	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	54-57
2479428-7	1989	Vitronectin adsorbed on carboxylic acid-containing copolymers reacted more strongly with a conformationally sensitive antivitronectin monoclonal antibody (MoAb) than vitronectin adsorbed to polystyrene and was more susceptible to cleavage by plasma proteases(s).	Carboxylic Acids	24-39	vitronectin	Homo sapiens	0-11
2479428-7	1989	Vitronectin adsorbed on carboxylic acid-containing copolymers reacted more strongly with a conformationally sensitive antivitronectin monoclonal antibody (MoAb) than vitronectin adsorbed to polystyrene and was more susceptible to cleavage by plasma proteases(s).	Carboxylic Acids	24-39	vitronectin	Homo sapiens	122-133
2738889-3	1989	Estrogen receptor binding is decreased by polar groups such as carboxylic acids (10) as well as sterically demanding substituents.	Carboxylic Acids	63-79	estrogen receptor 1	Homo sapiens	0-17
2552116-1	1989	A series of reduced-size hexapeptide analogues of LH-RH were synthesized that contain the residues corresponding to amino acid positions 4-9 and are linked to various carboxylic acids in place of residue 3.	Carboxylic Acids	167-183	gonadotropin releasing hormone 1	Rattus norvegicus	50-55
2434259-7	1986	It also showed that lambda HCMHC8 spanned 14 kb of DNA and contained exon segments estimated to code for two-thirds of a MHC including the carboxylic acid terminus.	Carboxylic Acids	139-154	major histocompatibility complex, class I, C	Homo sapiens	29-32
3214547-0	1988	Carboxylic acids from hairpencils of male Amauris butterflies (Lep.	Carboxylic Acids	0-16	leptin	Homo sapiens	63-66
3214547-2	1988	63 Carboxylic acids were identified from the male hairpencils of four species of the genus Amauris (Lep.	Carboxylic Acids	3-19	leptin	Homo sapiens	100-103
3597381-1	1987	Cytochrome P-450 was demonstrated to catalyze the oxidative cleavage of carboxylic acid esters to the corresponding carboxylic acids.	Carboxylic Acids	116-132	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	0-16
3295239-4	1987	This is a suitably protected carboxylic acid useful as an intermediate for the preparation of renin inhibitory peptides.	Carboxylic Acids	29-44	renin	Homo sapiens	94-99
3051003-4	1988	The presence of the carboxylic acid in the side chain of Asp20 was necessary for effective binding to the p70 protein.	Carboxylic Acids	20-35	ubiquitin associated and SH3 domain containing B	Homo sapiens	106-109
3215949-0	1988	Use of perfluorated carboxylic acids in the separation of metabolites of vasopressin prior to radioimmunoassay.	Carboxylic Acids	20-36	arginine vasopressin	Homo sapiens	73-84
3334852-7	1988	These data suggest that the amino residue of Lys-10 and the carboxylic acid of Lys-26 in peptide T-11 play crucial roles in the ionic binding of alpha 2-plasmin inhibitor to the tranexamic acid-binding site (lysine-binding site) of plasminogen.	Carboxylic Acids	60-75	serpin family F member 2	Homo sapiens	145-170
2826144-5	1987	In unliganded methemoglobin pK1, which is associated with carboxylic acid groups, ranges between 4.0 and 5.5 for the three methemoglobins; pK2, which is associated with histidines and terminal amino groups, ranges from 6.2 to 6.7.	Carboxylic Acids	58-73	hemoglobin subunit gamma 2	Homo sapiens	14-27
2826144-5	1987	In unliganded methemoglobin pK1, which is associated with carboxylic acid groups, ranges between 4.0 and 5.5 for the three methemoglobins; pK2, which is associated with histidines and terminal amino groups, ranges from 6.2 to 6.7.	Carboxylic Acids	58-73	pyruvate kinase L/R	Homo sapiens	28-31
3790092-0	1986	Methylation of calmodulin at carboxylic acid residues in erythrocytes.	Carboxylic Acids	29-44	calmodulin 1	Homo sapiens	15-25
3733951-2	1986	The carboxylic acids, as their tert.-butyldimethylsilylated derivatives, are readily separable on a SPB-1 (bonded) capillary column.	Carboxylic Acids	4-20	FtsJ RNA 2'-O-methyltransferase 3	Homo sapiens	100-105
2861971-1	1985	Crayfish glutamic acid decarboxylase (GAD) is inhibited by some aliphatic carboxylic acid analogs of glutamate and gamma-amino-n-butyric acid (GABA).	Carboxylic Acids	74-89	glutamate decarboxylase 1	Homo sapiens	9-36
3005829-4	1986	Following demethylation of rauwolscine or yohimbine, the resultant carboxylic acid derivatives were reacted with 4-aminophenethylamine to yield the respective 4-aminophenethyl carboxamides, 17 alpha-hydroxy-20 alpha-yohimban-16 beta-[N-4-amino-phenethyl]carboxamide (rau-pAPC) and 17 alpha-hydroxy-20 beta-yohimban-16 alpha-[N-4-aminophenethyl]carboxamide.	Carboxylic Acids	67-82	protocadherin 8	Homo sapiens	271-275
2991518-0	1985	Synthesis and biological activity of carboxylic acid replacement analogues of the potent angiotensin converting enzyme inhibitor 5(S)-benzamido-4-oxo-6-phenylhexanoyl-L-proline.	Carboxylic Acids	37-52	angiotensin I converting enzyme	Rattus norvegicus	89-118
3157348-1	1985	Rat ovarian 20 alpha-hydroxysteroid dehydrogenase was shown to be effectively inhibited by adenosine derivatives, nicotinamide derivatives, NADP analogs, N-alkylammonium chlorides, and carboxylic acids through coenzyme-competitive inhibition studies.	Carboxylic Acids	185-201	aldo-keto reductase family 1, member C3	Rattus norvegicus	12-49
2861971-1	1985	Crayfish glutamic acid decarboxylase (GAD) is inhibited by some aliphatic carboxylic acid analogs of glutamate and gamma-amino-n-butyric acid (GABA).	Carboxylic Acids	74-89	glutamate decarboxylase 1	Homo sapiens	38-41
6740235-4	1984	These molecules may then associate by the chelation of divalent copper, via the carboxylic acid groups of the terminal sialic acid moieties of the carbohydrate side chains, to form the mucin per se.	Carboxylic Acids	80-95	LOC100508689	Homo sapiens	185-190
6435620-1	1984	A series of C-terminal deleted analogs of human growth hormone-releasing factor (hGRF) with either an amidated or a free carboxylic acid C-terminus were synthesized by solid phase methodology.	Carboxylic Acids	121-136	growth hormone releasing hormone	Homo sapiens	81-85
6086648-1	1984	Using cultured GH1 cells, a growth hormone and prolactin-producing rat pituitary cell line, we have shown that n-butyrate and other short chain carboxylic acids stimulate histone acetylation and elicit a reduction of thyroid hormone nuclear receptor which is inversely related to the extent of acetylation (Samuels, H. H., Stanley, F., Casanova, J., and Shao, T. C. (1980) J. Biol.	Carboxylic Acids	144-160	prolactin	Rattus norvegicus	47-56
6086648-13	1984	These results suggest that prolactin gene expression is under partial regulatory repression which is reversed by a carboxylic acid-mediated postsynthetic modification event which allows for stimulation of the prolactin gene by thyroid hormone.	Carboxylic Acids	115-130	prolactin	Rattus norvegicus	27-36
6086648-13	1984	These results suggest that prolactin gene expression is under partial regulatory repression which is reversed by a carboxylic acid-mediated postsynthetic modification event which allows for stimulation of the prolactin gene by thyroid hormone.	Carboxylic Acids	115-130	prolactin	Rattus norvegicus	209-218
6704128-3	1984	Considering the magnitude of the stability constant of the citrate-aluminum chelate, citrate and perhaps other carboxylic acids may protect calmodulin, and thus cells, from toxic aluminum ions.	Carboxylic Acids	111-127	calmodulin 1	Homo sapiens	140-150
1244102-3	1975	Carboxylic acid groups have been methylated with BCl3-methanol and phenolic and amine groups have been acylated to pentafluoropropionyl derivatives.	Carboxylic Acids	0-15	BCL3 transcription coactivator	Homo sapiens	49-53
7139917-7	1982	Carboxylic acid (M-1)- ions uniquely lose either CO2 (44 atomic mass units) or both H2O and CO2 (62 atomic mass units).	Carboxylic Acids	0-15	complement C2	Homo sapiens	84-95
7082376-7	1982	The phenomenon of intramolecular rearrangement of ester glucuronides must be considered whenever beta-glucuronidase is used in the analysis of conjugates of carboxylic acids.	Carboxylic Acids	157-173	glucuronidase beta	Homo sapiens	97-115
7241358-4	1981	Retention data are given for some common degradation products (C-17 ketones and C-17 carboxylic acid derivatives) and for methyl-, propyl-, and butylparabens with these mobile solvents.	Carboxylic Acids	85-100	cytokine like 1	Homo sapiens	80-84
7470554-6	1980	These results are interpreted in terms of methylation of carboxylic acid groups in fibrinogen by diazomethane providing a reduction of both negative charge and intermolecular repulsion, thereby enabling the modified fibrinogen molecules to polymerize.	Carboxylic Acids	57-72	fibrinogen beta chain	Homo sapiens	83-93
7470554-6	1980	These results are interpreted in terms of methylation of carboxylic acid groups in fibrinogen by diazomethane providing a reduction of both negative charge and intermolecular repulsion, thereby enabling the modified fibrinogen molecules to polymerize.	Carboxylic Acids	57-72	fibrinogen beta chain	Homo sapiens	216-226
6243999-3	1980	Spin labels derived from five carboxylic acids of different lengths were synthesized and incorporated in varying amounts into multilamellar and unilamellar vesicles made up of four different phosphatidylcholines.	Carboxylic Acids	30-46	spindlin 1	Homo sapiens	0-4
803968-12	1975	CPK molecular model studies suggested the functional group and the carboxylic acid must be able to fit within a site between 6.3 and 7.0 A in maximal length.	Carboxylic Acids	67-82	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Homo sapiens	0-3
6631216-1	1983	Incubation of the four purified HMG-CoA reductase phosphatases with the sodium salts of eleven polycarboxylic acids at concentrations of 40 mM, inactivated the enzymes to different degrees depending on the structure of the carboxylic acids.	Carboxylic Acids	99-115	3-hydroxy-3-methylglutaryl-CoA reductase	Rattus norvegicus	32-49
7470554-1	1980	To study the effect of the acidic amino acid residues on the physiological polymerization and clot formation of fibrinogen, the fibrinogen system was polymerized by interaction with diazomethane, a specific group reagent which modifies the carboxylic acid residues via the process of methylation.	Carboxylic Acids	240-255	fibrinogen beta chain	Homo sapiens	112-122
7470554-1	1980	To study the effect of the acidic amino acid residues on the physiological polymerization and clot formation of fibrinogen, the fibrinogen system was polymerized by interaction with diazomethane, a specific group reagent which modifies the carboxylic acid residues via the process of methylation.	Carboxylic Acids	240-255	fibrinogen beta chain	Homo sapiens	128-138
1174028-2	1975	The synthesis of the N-(1-adamantyl)-carboxylic acid amides (IV, VII, X) could be reallzed by interaction of I with carboxylic acids (II, V, VIII) via the carboxylic acid chlorides (III, VI, IX), the latter not being isolated for the simplification of the process.	Carboxylic Acids	116-132	cytochrome c oxidase subunit 8A	Homo sapiens	141-145
14420490-0	1959	Effect of insulin on the incorporation of C14 from C14-labeled carboxylic acids and bicarbonate into the protein of isolated rat diaphragm.	Carboxylic Acids	63-79	anti-Mullerian hormone receptor type 2	Rattus norvegicus	42-45
4226961-2	1967	Like aldehyde oxidase from other mammalian species, human liver aldehyde oxidase is an enzyme with dual substrate specificity, possessing the ability to catalyze not only the oxidation of aldehydes to the corresponding carboxylic acids, but also the hydroxylation of a number of nonaldehydic heterocyclic compounds; its relative activity towards the latter group of substrates is low, however, when compared with that of liver aldehyde oxidase from rabbit and guinea pig.	Carboxylic Acids	219-235	aldehyde oxidase 1	Homo sapiens	5-21
4226961-2	1967	Like aldehyde oxidase from other mammalian species, human liver aldehyde oxidase is an enzyme with dual substrate specificity, possessing the ability to catalyze not only the oxidation of aldehydes to the corresponding carboxylic acids, but also the hydroxylation of a number of nonaldehydic heterocyclic compounds; its relative activity towards the latter group of substrates is low, however, when compared with that of liver aldehyde oxidase from rabbit and guinea pig.	Carboxylic Acids	219-235	aldehyde oxidase 1	Homo sapiens	64-80
4226961-2	1967	Like aldehyde oxidase from other mammalian species, human liver aldehyde oxidase is an enzyme with dual substrate specificity, possessing the ability to catalyze not only the oxidation of aldehydes to the corresponding carboxylic acids, but also the hydroxylation of a number of nonaldehydic heterocyclic compounds; its relative activity towards the latter group of substrates is low, however, when compared with that of liver aldehyde oxidase from rabbit and guinea pig.	Carboxylic Acids	219-235	aldehyde oxidase 1	Homo sapiens	64-80
14420490-0	1959	Effect of insulin on the incorporation of C14 from C14-labeled carboxylic acids and bicarbonate into the protein of isolated rat diaphragm.	Carboxylic Acids	63-79	anti-Mullerian hormone receptor type 2	Rattus norvegicus	51-54
33784603-6	2021	In this study, by hybridizing the carboxylic acid of GFT505 and the parent nucleus of sulfuretin, we pioneeringly designed and synthetized a series of novel dual PPAR-alpha/delta agonists, expecting to provide a better benefit/risk ratio for PPARs.	Carboxylic Acids	34-49	peroxisome proliferator activated receptor alpha	Homo sapiens	162-178
34032451-1	2021	The visible-light photoredox/[Co(III)] cocatalyzed dehydrogenative functionalization of cyclic and acyclic styryl derivatives with carboxylic acids is documented.	Carboxylic Acids	131-147	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	30-37
33961345-0	2021	Crystal Phase Effects on the Gas-Phase Ketonization of Small Carboxylic Acids over TiO2 Catalysts.	Carboxylic Acids	61-77	PAXIP1 associated glutamate rich protein 1	Homo sapiens	29-32
33662540-3	2021	This letter describes the SAR efforts that led to the discovery of CYR715, a novel carboxylic acid-containing sGC stimulator, with an improved metabolic profile relative to our previously described stimulator, IWP-051.	Carboxylic Acids	83-98	guanylate cyclase 1 soluble subunit alpha 1	Rattus norvegicus	110-113
33984105-8	2021	We propose that this is a consequence of Eu3+ binding to both Tpy and to free carboxylic acid groups on the insulin surface.	Carboxylic Acids	78-93	insulin	Homo sapiens	108-115
33601161-6	2021	During the fragmentation process of dolutegravir and its degradation products DP1 to DP3 a formal addition of oxygen resulting in the respective carboxylic acid fragments was detected.	Carboxylic Acids	145-160	prostaglandin D2 receptor	Homo sapiens	78-81
33876634-0	2021	Deoxyfluorination of Carboxylic Acids with KF and Highly Electron-Deficient Fluoroarenes.	Carboxylic Acids	21-37	arylformamidase	Homo sapiens	43-45
33876634-1	2021	A deoxyfluorination reaction of carboxylic acids using potassium fluoride (KF) and highly electron-deficient fluoroarenes is reported here, giving acyl fluorides in moderate to excellent yield (57-92% based on NMR integration and 34-95% for isolated examples).	Carboxylic Acids	32-48	arylformamidase	Homo sapiens	75-77
33601161-5	2021	Furthermore, two carboxylic acid derivatives (DP4 and DP5) could be identified, which can be explained as the result of the hydrolysis of the exocyclic amide bond of dolutegravir and DP1, respectively.	Carboxylic Acids	17-32	transcription factor Dp family member 3	Homo sapiens	46-49
33601161-6	2021	During the fragmentation process of dolutegravir and its degradation products DP1 to DP3 a formal addition of oxygen resulting in the respective carboxylic acid fragments was detected.	Carboxylic Acids	145-160	APC regulator of WNT signaling pathway	Homo sapiens	85-88
33601161-5	2021	Furthermore, two carboxylic acid derivatives (DP4 and DP5) could be identified, which can be explained as the result of the hydrolysis of the exocyclic amide bond of dolutegravir and DP1, respectively.	Carboxylic Acids	17-32	harakiri, BCL2 interacting protein	Homo sapiens	54-57
33601161-5	2021	Furthermore, two carboxylic acid derivatives (DP4 and DP5) could be identified, which can be explained as the result of the hydrolysis of the exocyclic amide bond of dolutegravir and DP1, respectively.	Carboxylic Acids	17-32	prostaglandin D2 receptor	Homo sapiens	183-186
33601161-7	2021	This could be evidenced based on high resolution masses of the fragments as well as the comparison of the MS/MS spectra of the fragments with the spectra of the carboxylic acids DP4 and DP5.	Carboxylic Acids	161-177	transcription factor Dp family member 3	Homo sapiens	178-181
33917225-1	2021	A family of four push-pull porphyrazines of A3B type, where each unit A contains two peripheral propyl chains and the unit B is endowed with a carboxylic acid, were prepared.	Carboxylic Acids	143-158	apolipoprotein B mRNA editing enzyme catalytic subunit 3B	Homo sapiens	44-47
33348096-2	2021	In this work, a novel quinoline-benzimidazole conjugate containing one carboxylic acid group (QBM) was designed, and the QBM displayed highly selective fluorescence quenching response towards Pd2+ over other metal cations in aqueous solution.	Carboxylic Acids	71-86	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	192-195
33617218-10	2021	We postulate that interactions between a carboxylic acid substituent of herboxidiene and positively charged SF3B1 side chains in the inhibitor binding channel are needed to maintain inhibitor occupancy while counteracting the SF3B transition to a closed state that is required for stable U2 snRNP interactions with the intron.	Carboxylic Acids	41-56	splicing factor 3b subunit 1	Homo sapiens	108-113
33617218-10	2021	We postulate that interactions between a carboxylic acid substituent of herboxidiene and positively charged SF3B1 side chains in the inhibitor binding channel are needed to maintain inhibitor occupancy while counteracting the SF3B transition to a closed state that is required for stable U2 snRNP interactions with the intron.	Carboxylic Acids	41-56	LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated	Homo sapiens	291-296
33715419-2	2021	Materials & methods: Bioinformatic docking of candidate molecules featuring a wide range of carboxylic acid bioisosteres into complex with GPR40 was performed using TAK-875 and GW9508 templates.	Carboxylic Acids	92-107	free fatty acid receptor 1	Homo sapiens	139-144
33600157-4	2021	We showed that recombinant murine BCO2 converted the alcohol, aldehyde, and carboxylic acid of a beta-apocarotenoid substrate by oxidative cleavage at position C9,C10 into a beta-ionone and a diapocarotenoid product.	Carboxylic Acids	76-91	beta-carotene oxygenase 2	Mus musculus	34-38
33671136-4	2021	Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups.	Carboxylic Acids	114-129	TNF superfamily member 10	Homo sapiens	59-64
33671136-4	2021	Here, we present two different ways of covalently grafting TRAIL onto maghemite nanoparticles (NPs): (a) by using carboxylic acid groups of the protein to graft it onto maghemite NPs previously functionalized with amino groups, and (b) by using the amino functions of the protein to graft it onto NPs functionalized with carboxylic acid groups.	Carboxylic Acids	321-336	TNF superfamily member 10	Homo sapiens	59-64
33248147-8	2021	The previously reported carboxylic acid of SP, whose identity was confirmed by high-resolution mass spectrometric analysis, did not show cross-reactivity in the applied immunoassay and did not contribute to SP-like immunoreactivity results.	Carboxylic Acids	24-39	tachykinin precursor 1	Homo sapiens	43-45
33569679-4	2021	AuNPs/Cu-MOF composite was successfully synthesized by amidation reaction between AuNPs functionalized with amino group and Cu-MOFs containing carboxylic acid.	Carboxylic Acids	143-158	lysine acetyltransferase 8	Homo sapiens	9-12
32557875-1	2021	C(1)-Ammonium enolates are powerful, catalytically generated synthetic intermediates applied in the enantioselective alpha - functionalization of carboxylic acid derivatives.	Carboxylic Acids	146-161	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	0-4
33321618-3	2021	The modified beta-CD was grafted with Graphene oxide (GO), and the resulting platform gain many functional groups, including the hydroxyl (-OH), carboxylic acid (-COOH), and amine functional groups (-NH2).	Carboxylic Acids	145-160	ACD shelterin complex subunit and telomerase recruitment factor	Homo sapiens	13-20
32557875-2	2021	This review describes the recent developments in the generation and application of C(1)-ammonium enolates from various precursors (carboxylic acids, anhydrides, acyl imidazoles, aryl esters, alpha-diazoketones, alkyl halides) using isothiourea Lewis base organocatalysts.	Carboxylic Acids	131-147	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	83-87
33197310-3	2020	A Bcl-2-dephosphorylation probe, S1-6e, was designed by installing a carboxylic acid group to a Bcl-2 inhibitor.	Carboxylic Acids	69-84	BCL2 apoptosis regulator	Homo sapiens	2-7
33328099-1	2021	ALDH1A1, one important member of 19 ALDHs, can metabolize reactive aldehydes to their corresponding carboxylic acid derivatives and play important physiological and toxicological roles in many areas, including CNS, metabolic disorders, and cancers.	Carboxylic Acids	100-115	aldehyde dehydrogenase 1 family member A1	Homo sapiens	0-7
33326249-6	2020	Quartz crystal microbalance with dissipation monitoring (QCM-D) experiments revealed higher adsorbed mass of cationic lignin onto the CLP-coated substrate in comparison to the film prepared from dissolved lignin, suggesting preferential adsorption via the carboxylic acid enriched surfaces of CLPs.	Carboxylic Acids	256-271	calmodulin like 3	Homo sapiens	134-137
33521463-0	2021	Au/Ag/Cu-Mixed Catalysts for the Eco-Friendly Oxidation of 5-Hydroxymethylfurfural and Related Compounds to Carboxylic Acids under Atmospheric Oxygen in Water.	Carboxylic Acids	108-124	ciliogenesis associated kinase 1	Homo sapiens	33-36
33478031-1	2021	Aldehyde dehydrogenase 1A3 (ALDH1A3) belongs to an enzymatic superfamily composed by 19 different isoforms, with a scavenger role, involved in the oxidation of a plethora of aldehydes to the respective carboxylic acids, through a NAD+-dependent reaction.	Carboxylic Acids	202-218	aldehyde dehydrogenase family 1, subfamily A3	Mus musculus	0-26
33478031-1	2021	Aldehyde dehydrogenase 1A3 (ALDH1A3) belongs to an enzymatic superfamily composed by 19 different isoforms, with a scavenger role, involved in the oxidation of a plethora of aldehydes to the respective carboxylic acids, through a NAD+-dependent reaction.	Carboxylic Acids	202-218	aldehyde dehydrogenase family 1, subfamily A3	Mus musculus	28-35
33215924-5	2020	X-ray crystallography of 11s and related thieno[3,2-d]pyrimidines bound to STK17B revealed a unique P-loop conformation characterized by a salt bridge between R41 and the carboxylic acid of the inhibitor.	Carboxylic Acids	171-186	serine/threonine kinase 17b	Homo sapiens	75-81
33179941-3	2020	Herein, we employ an STM break junction (STM-BJ) technique to investigate the acid-base chemistry of carboxylic acid-based molecules at a Au (111) model surface and propose a prototype of a single-molecule pH sensor for the first time.	Carboxylic Acids	101-116	sulfotransferase family 1A member 3	Homo sapiens	21-24
33179941-3	2020	Herein, we employ an STM break junction (STM-BJ) technique to investigate the acid-base chemistry of carboxylic acid-based molecules at a Au (111) model surface and propose a prototype of a single-molecule pH sensor for the first time.	Carboxylic Acids	101-116	sulfotransferase family 1A member 3	Homo sapiens	41-44
33197310-3	2020	A Bcl-2-dephosphorylation probe, S1-6e, was designed by installing a carboxylic acid group to a Bcl-2 inhibitor.	Carboxylic Acids	69-84	BCL2 apoptosis regulator	Homo sapiens	96-101
32809824-3	2020	Herein, we describe the design, synthesis, and evaluation of carboxylic acid-based ACC inhibitors with organic anion transporting polypeptide (OATP) substrate properties, which facilitated selective distribution of the compounds at the therapeutic site of action (liver) relative to the periphery.	Carboxylic Acids	61-76	solute carrier organic anion transporter family member 1A2	Homo sapiens	103-141
32882265-5	2020	Subsequently, carboxylic acid-end MUC1 aptamer was used to covalently decorate the surface amine groups of the exosomes via amide bond formation to provide selective guided drug delivery (DOX@exosome-apt).	Carboxylic Acids	14-29	mucin 1, transmembrane	Mus musculus	34-38
33078806-1	2020	Here, we used malononitrile or AMBN as a cyanating agent to develop efficient and practical protocols for Cu-mediated decarboxylative cyanations, under aerobic conditions, of aryl carboxylic acids bearing nitro and methoxyl substituents at the ortho position as well as of heteroaromatic carboxylic acids.	Carboxylic Acids	180-196	ameloblastin	Homo sapiens	31-35
33146948-2	2021	Early setbacks with complex rotameric amide mixtures, provided the ideal environment for the discovery of the Oxa-Shono reaction-Osp 2 -Csp 3 bond cleavage of esters-providing two useful products in one-step: aldehyde selective oxidation level products and a mild de-esterification method to afford carboxylic acids in the process.	Carboxylic Acids	299-315	claudin 11	Homo sapiens	129-132
33090000-1	2020	Under irradiation of 456 nm blue light-emitting diodes, PPh3 catalyzes the iododecarboxylation of aliphatic carboxylic acid derived N-(acyloxy)phthalimide with lithium iodide as an iodine source.	Carboxylic Acids	108-123	caveolin 1	Homo sapiens	56-60
32920334-1	2020	Carbohydrate-rich waste streams can be used for bioproduction of medium-chain carboxylic acids (MCCA) such as caproic acid.	Carboxylic Acids	78-94	methylcrotonyl-CoA carboxylase subunit 1	Homo sapiens	96-100
33214850-2	2020	Several structure-activity relationship studies on both human relaxin 3 (containing 3 disulfide bonds) and its analogue A2 (two disulfide bonds) suggest that the C-terminal carboxylic acid of the tryptophan residue in the B-chain is important for RXFP3 activity.	Carboxylic Acids	173-188	relaxin 3	Homo sapiens	62-71
33214850-2	2020	Several structure-activity relationship studies on both human relaxin 3 (containing 3 disulfide bonds) and its analogue A2 (two disulfide bonds) suggest that the C-terminal carboxylic acid of the tryptophan residue in the B-chain is important for RXFP3 activity.	Carboxylic Acids	173-188	relaxin family peptide receptor 3	Homo sapiens	247-252
32809824-3	2020	Herein, we describe the design, synthesis, and evaluation of carboxylic acid-based ACC inhibitors with organic anion transporting polypeptide (OATP) substrate properties, which facilitated selective distribution of the compounds at the therapeutic site of action (liver) relative to the periphery.	Carboxylic Acids	61-76	solute carrier organic anion transporter family member 1A2	Homo sapiens	143-147
32787092-5	2020	Our results demonstrate that this prodrug strategy can be generalized to a variety of carboxylic acid-containing drug structures that satisfy the structural requirements of blood-brain barrier diffusion and FAAH substrate recognition.	Carboxylic Acids	86-101	fatty acid amide hydrolase	Homo sapiens	207-211
32743632-0	2020	Investigating the interaction between three perfluorinated carboxylic acids and the G protein-coupled estrogen receptor: spectroscopic analyses and computational simulations.	Carboxylic Acids	59-75	G protein-coupled estrogen receptor 1	Homo sapiens	84-119
32249465-2	2020	It is a pro-drug that is extensively metabolized to carebastine, its active carboxylic acid metabolite, by the hepatic microsomal isoenzyme cytochrome P450 (CYP).	Carboxylic Acids	76-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	140-155
32249465-2	2020	It is a pro-drug that is extensively metabolized to carebastine, its active carboxylic acid metabolite, by the hepatic microsomal isoenzyme cytochrome P450 (CYP).	Carboxylic Acids	76-91	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	157-160
32691597-0	2020	Synthesis of Acyl Fluorides from Carboxylic Acids Using NaF-Assisted Deoxofluorination with XtalFluor-E.	Carboxylic Acids	33-49	C-X-C motif chemokine ligand 8	Homo sapiens	56-59
32446711-3	2020	The natural ligand heme has two carboxylic acids which interact in the beta1 heme nitric oxide oxygen binding (HNOX) domain with the amino acids of the highly conserved Y-x-S-x-R motif.	Carboxylic Acids	32-48	BCL2 related protein A1	Homo sapiens	71-76
31769929-2	2020	Precisely, the carboxylic group of alpha-lipoic acid, as addend of the modified MoS 2 obtained upon 1,2-dithiolane functionalization, was employed as anchor site for the in-situ preparation and immobilization of the CdS nanoparticles in an one-pot two-step process.	Carboxylic Acids	15-25	CDP-diacylglycerol synthase 1	Homo sapiens	216-219
32414235-0	2020	Freezing of Aqueous Carboxylic Acid Solutions on Ice.	Carboxylic Acids	20-35	carboxylesterase 2	Homo sapiens	49-52
32385937-0	2020	Visible Light-induced Decarboxylative Alkylation of Heterocyclic Aromatics with Carboxylic Acids via Anthocyanin as a Photocatalyst.	Carboxylic Acids	80-96	DDB1 and CUL4 associated factor 7	Homo sapiens	101-112
32463165-1	2020	Mitochondrial aldehyde dehydrogenase 2 (ALDH2) is an enzyme that detoxifies aldehydes by converting them to carboxylic acids.	Carboxylic Acids	108-124	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	40-45
32250511-2	2020	Here we describe the mechanochemical synthesis of a reticular family of crystalline heterobimetallic metal-organic frameworks (MOFs) by polymerization of molecular Ru2 [II,III]  complexes, featuring unprotected carboxylic acid substituents, with Cu(OAc)2 .	Carboxylic Acids	211-226	doublecortin domain containing 2	Homo sapiens	164-167
32631572-2	2020	Until now, the most potent aldose reductase inhibitors have been carboxylic acid derivatives, which poorly permeate biological membranes.	Carboxylic Acids	65-80	aldo-keto reductase family 1 member B	Homo sapiens	27-43
32108961-10	2020	Our results revealed that hydroxylation of methyl group at C-21 position to form TUG-891 alcohol (M5) followed by oxidation to yield TUG-891 aldehyde (M7) and carboxylic acid (M4) were the major metabolism processes.	Carboxylic Acids	159-174	TBL1X/Y related 1	Homo sapiens	59-63
32470284-2	2020	Herein, we prepared a hydrothermally stable Eu-MOF that also resisted acid and base using a bifunctional organic ligand containing carboxylic acid groups which are easily coordinated to Eu ions, and Eu-phobic tetrazolyl groups as potential proton-hopping sites.	Carboxylic Acids	131-146	lysine acetyltransferase 8	Homo sapiens	47-50
32515597-1	2020	Free cationic manganese atoms and clusters Mnx+ (x = 1-3) have been reacted with small carboxylic acids (formic, acetic, and propionic acids) and methyl acetate in a flow tube reactor held at room temperature.	Carboxylic Acids	87-103	keratin 86	Homo sapiens	43-46
32398126-6	2020	Metabolomics analysis revealed that the relative concentrations of rumen microbial metabolites (mainly amino acids, carboxylic acids, and fatty acids) and the absolute concentrations of volatile fatty acids were higher in the high-MPY cows.	Carboxylic Acids	116-132	PY	Bos taurus	231-234
32133856-3	2020	Different sp3 carbon-bearing carboxylic acids were successfully employed as substrates, including phenylacetic acid-type substrates, as well as aliphatic carboxylic acids.	Carboxylic Acids	29-45	Sp3 transcription factor	Homo sapiens	10-13
32062971-3	2020	6:2 FTS was simultaneously transformed to perfluoroalkyl carboxylic acids (C2-C7 PFCAs) of different chain length, with perfluorohexanoic acid (C6) as the predominant one.	Carboxylic Acids	42-73	AKT interacting protein	Homo sapiens	4-7
31782480-1	2020	WS2 nanotubes functionalized with carboxylic acid functions (WS2-COOH) were used for improved immobilization of the enzyme tyrosinase in order to form an electrochemical biosensor towards catechol and dopamine.	Carboxylic Acids	34-49	tyrosinase	Homo sapiens	123-133
31806389-6	2020	All the materials, except the carboxylic acid functionalised one, offer high PPO loading capabilities and the immobilisation speed increases with functionalisation.	Carboxylic Acids	30-45	polyphenol oxidase, chloroplastic	Malus domestica	77-80
32159546-1	2020	A bulky carboxylic acid bearing one 1-adamantylmethyl and two methyl substituents at the alpha-position is demonstrated to work as an efficient carboxylate ligand source in Pd-catalyzed intermolecular C(sp2)-H bond arylation reactions.	Carboxylic Acids	8-23	Sp2 transcription factor	Homo sapiens	201-206
32213911-1	2020	2-Oxoesters constitute an important class of potent and selective inhibitors of human cytosolic phospholipase A2 (GIVA cPLA2) combining an aromatic scaffold or a long aliphatic chain with a short aliphatic chain containing a free carboxylic acid.	Carboxylic Acids	230-245	phospholipase A2 group IVA	Homo sapiens	119-124
31721064-8	2020	For females, an inverse association between the sum perfluoroalkyl carboxylic acids (SigmaPFCA) and SHBG was seen.	Carboxylic Acids	52-83	sex hormone binding globulin	Homo sapiens	100-104
32914122-6	2020	On the open surface of the ATR crystal this adduct underwent a fast oxidization into carboxylic acid as evidenced by the disappearance of the band at 1729 cm-1 and the formation of a new band at 1712 cm-1 and its subsequent conversion into a carboxylate band under basic conditions.	Carboxylic Acids	85-100	ATR serine/threonine kinase	Homo sapiens	27-30
32213911-1	2020	2-Oxoesters constitute an important class of potent and selective inhibitors of human cytosolic phospholipase A2 (GIVA cPLA2) combining an aromatic scaffold or a long aliphatic chain with a short aliphatic chain containing a free carboxylic acid.	Carboxylic Acids	230-245	phospholipase A2 group IVA	Homo sapiens	86-112
31492336-6	2020	The metallic Cu0 nanoparticles and alkaline HAP nanorods in the Cux/HAP catalyst synergistically catalyzed the oxidation of 1,2-propanediol to carboxylic acid.	Carboxylic Acids	143-158	cut like homeobox 1	Homo sapiens	64-67
32435420-3	2020	Superiorly, benzofuran-containing carboxylic acid derivatives 9b, 9e, and 9f acted as submicromolar hCA IX inhibitors with KIs = 0.91, 0.79, and 0.56 muM, respectively, with selective inhibitory profile against the target hCA IX over the off-target isoforms hCA I and II (SIs: 2 to >63 and 4-47, respectively).	Carboxylic Acids	34-49	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	258-270
32001263-11	2020	Out of 13 mirSNP"s analyzed, CYP2C19 rs4244285 was associated with clopidogrel drug resistance and clopidogrel carboxylic acid metabolite in urine and plasma.	Carboxylic Acids	111-126	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	29-36
31915112-4	2020	In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with KI values in lower micromolar potency (KIs = 0.36-0.85 muM for CA IX/XII).	Carboxylic Acids	57-72	carbonic anhydrase 3	Homo sapiens	155-161
31889664-1	2020	One of the most commonly used strategies to reduce hERG (human ether-a-go-go) activity in the drug candidates is introduction of a carboxylic acid group.	Carboxylic Acids	131-146	ETS transcription factor ERG	Homo sapiens	51-55
31889664-2	2020	During the optimization of PPARdelta modulators, some of the compounds containing a carboxylic acid were found to inhibit the hERG channel in a patch clamp assay.	Carboxylic Acids	84-99	peroxisome proliferator activated receptor delta	Homo sapiens	27-36
31889664-2	2020	During the optimization of PPARdelta modulators, some of the compounds containing a carboxylic acid were found to inhibit the hERG channel in a patch clamp assay.	Carboxylic Acids	84-99	ETS transcription factor ERG	Homo sapiens	126-130
31881454-2	2020	Additionally, piperazinylquinolones (PQs) have enough flexibility for chemical modification via their N-4 of piperazine ring and carboxylic acid at C-3.	Carboxylic Acids	129-144	complement C3	Homo sapiens	148-151
31808482-3	2020	Modification of the gastrin-releasing peptide receptor (GRPR) selective agonist [d-Phe6, beta-Ala11, Ala13, Nle14]Bn(6-14) with the carboxylic acid derivative yielded a bioconjugate with an optimal receptor activation and internalisation profile.	Carboxylic Acids	132-147	gastrin releasing peptide receptor	Homo sapiens	20-54
31808482-3	2020	Modification of the gastrin-releasing peptide receptor (GRPR) selective agonist [d-Phe6, beta-Ala11, Ala13, Nle14]Bn(6-14) with the carboxylic acid derivative yielded a bioconjugate with an optimal receptor activation and internalisation profile.	Carboxylic Acids	132-147	gastrin releasing peptide receptor	Homo sapiens	56-60
31812623-2	2020	Haptens containing terminal carboxylic group were conjugated to bovine serum albumin (BSA), rabbit serum albumin (RSA) or ovalbumin (OVA).	Carboxylic Acids	28-38	albumin	Oryctolagus cuniculus	71-84
31812623-2	2020	Haptens containing terminal carboxylic group were conjugated to bovine serum albumin (BSA), rabbit serum albumin (RSA) or ovalbumin (OVA).	Carboxylic Acids	28-38	albumin	Oryctolagus cuniculus	99-112
32071687-5	2020	We were also intrigued by the zinc coordination made by one of the carboxylic acids of LBQ657, leading us to explore alternative linkers to efficiently engage zinc for NEP inhibition.	Carboxylic Acids	67-83	membrane metalloendopeptidase	Homo sapiens	168-171
31915112-4	2020	In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with KI values in lower micromolar potency (KIs = 0.36-0.85 muM for CA IX/XII).	Carboxylic Acids	57-72	carbonic anhydrase 9	Homo sapiens	140-145
31915112-4	2020	In addition, compounds having hydroxamic acid (15a-b) or carboxylic acid (16a-b) functionalities resulted in greater selectivity ratios for CA IX/XII over CAI/II in the range of 4.1-121.5 although with KI values in lower micromolar potency (KIs = 0.36-0.85 muM for CA IX/XII).	Carboxylic Acids	57-72	carbonic anhydrase 9	Homo sapiens	265-270
31782079-8	2020	Furthermore, the application of 1-aminocyclopropane-1-carboxylic acid (ACC) significantly enhanced the expression level of ZFP5 while the application of 2-aminoethoxyvinyl glycine (AVG) had the opposite effect when either Pi or potassium was deprived.	Carboxylic Acids	32-69	zinc finger protein 5	Arabidopsis thaliana	123-127
31598849-8	2020	Further analysis of protein-protein interaction (PPI) revealed that Stk39 and Ass1 interacting through Mapk14-Ywhae were node proteins and participated in inflammatory response, carboxylic acid metabolic process, and small molecule metabolic process.	Carboxylic Acids	178-193	serine threonine kinase 39	Rattus norvegicus	68-73
31598849-8	2020	Further analysis of protein-protein interaction (PPI) revealed that Stk39 and Ass1 interacting through Mapk14-Ywhae were node proteins and participated in inflammatory response, carboxylic acid metabolic process, and small molecule metabolic process.	Carboxylic Acids	178-193	argininosuccinate synthase 1	Rattus norvegicus	78-82
31598849-8	2020	Further analysis of protein-protein interaction (PPI) revealed that Stk39 and Ass1 interacting through Mapk14-Ywhae were node proteins and participated in inflammatory response, carboxylic acid metabolic process, and small molecule metabolic process.	Carboxylic Acids	178-193	mitogen activated protein kinase 14	Rattus norvegicus	103-109
31598849-8	2020	Further analysis of protein-protein interaction (PPI) revealed that Stk39 and Ass1 interacting through Mapk14-Ywhae were node proteins and participated in inflammatory response, carboxylic acid metabolic process, and small molecule metabolic process.	Carboxylic Acids	178-193	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon	Rattus norvegicus	110-115
31654148-7	2020	Thus, the role of carboxylic acid reduction is likely of importance in the production of BCOH formation during the degradation of BCAA such as leucine.	Carboxylic Acids	18-33	AT-rich interaction domain 4B	Homo sapiens	130-134
31774676-5	2019	Notably, the introduction of a carboxylic acid group at position 30 was important for dual 5-LOX/COX inhibitory activity; furthermore, its combination with a carbonyl group at C-11 considerably increased 5-LOX inhibition.	Carboxylic Acids	31-46	arachidonate 5-lipoxygenase	Homo sapiens	91-96
31192586-2	2019	Counterintuitively, crystal structures of CatA and its homologues show a cluster of Glu and Asp residues binding the C-terminal carboxylic acid of the product or inhibitor.	Carboxylic Acids	128-143	cathepsin A	Homo sapiens	42-46
31774676-5	2019	Notably, the introduction of a carboxylic acid group at position 30 was important for dual 5-LOX/COX inhibitory activity; furthermore, its combination with a carbonyl group at C-11 considerably increased 5-LOX inhibition.	Carboxylic Acids	31-46	arachidonate 5-lipoxygenase	Homo sapiens	204-209
31774676-6	2019	Also, the presence of an alpha-hydroxy group at C-2 or a carboxylic acid group at C-23 markedly suppressed the 5-LOX activity.	Carboxylic Acids	57-72	arachidonate 5-lipoxygenase	Homo sapiens	111-116
31216077-4	2019	METHODS: The ion-molecule reactions of negative precursor ions (OH- , O - , O2  - , NO2 - and NO3 - ) with five aldehydes and four carboxylic acids was investigated in order to provide product ions and rate constants for the quantification of these compounds by negative ion SIFT-MS.	Carboxylic Acids	131-147	NBL1, DAN family BMP antagonist	Homo sapiens	94-97
31659919-1	2019	Aim: Targeting aldose reductase and oxidative stress with quinoxalin-2(1H)-one derivatives having a 1-hydroxypyrazole head as the bioisosteric replacement of carboxylic acid.	Carboxylic Acids	158-173	aldo-keto reductase family 1 member B	Homo sapiens	15-31
31703893-2	2019	In order to confirm key structural features to activate PPARalpha and/or PPARgamma, we have adopted structural modifications in the following parts: (i) the benzopyran core (hydrophobic nucleus) by benzopyran-4-one, dihydrobenzopyran or benzopyran-4-ol; (ii) the side chain at 2-position by shortening to C3, C4 and C5-carbons versus C-9-carbons of polycerasoidol; (iii) the carboxylic group (polar head) by oxygenated groups (hydroxyl, acetoxy, epoxide, ester, aldehyde) or non-oxygenated motifs (allyl and alkyl).	Carboxylic Acids	375-385	peroxisome proliferator activated receptor alpha	Homo sapiens	56-65
31348936-3	2019	For targeted delivery of anticancer therapeutics to alphavbeta3-expressing tumor cells, cyclic arginylglycylaspartic acid (RGD) peptide was covalently conjugated to the surface of carboxylic acid-functionalized carbon nanotubes (fCNTs), and the topoisomerase I inhibitor camptothecin (CPT) was encapsulated in the fCNTs (CPT@fCNT-RGD).	Carboxylic Acids	180-195	choline phosphotransferase 1	Homo sapiens	245-289
31580650-2	2019	MCP-SELEX isolates bound aptamers via highly efficient chemical cross-linking between amino groups of target proteins and activated carboxylic acid groups on magnetic beads (>90% coupling efficiency).	Carboxylic Acids	132-147	CD46 molecule	Homo sapiens	0-3
31660558-2	2019	Surface chirality that shortens the surface residence time of Abeta, for example, R-cysteine modification with carboxylic, secondary amine and thiol groups surrounding the chiral center, can retard Abeta oligomerization and fibrillation.	Carboxylic Acids	111-121	amyloid beta precursor protein	Homo sapiens	62-67
31660558-2	2019	Surface chirality that shortens the surface residence time of Abeta, for example, R-cysteine modification with carboxylic, secondary amine and thiol groups surrounding the chiral center, can retard Abeta oligomerization and fibrillation.	Carboxylic Acids	111-121	amyloid beta precursor protein	Homo sapiens	198-203
31525063-1	2019	Re2(CO)10 efficiently catalyzes the direct reduction of various carboxylic acids under mild conditions (rt, irradiation 350 or 395 nm).	Carboxylic Acids	64-80	G protein-coupled receptor 161	Homo sapiens	0-3
31666507-4	2019	The results provide direct evidence that diamond surfaces are coated by sp2-, and sp3-bonded amorphous carbon and functional groups of carboxylic acids (e.g., carboxyl, carboxylate, methyl, and methylene), indicating the geosynthesis of organic compounds in deep hydrous fluids.	Carboxylic Acids	135-151	Sp2 transcription factor	Homo sapiens	72-75
31666507-4	2019	The results provide direct evidence that diamond surfaces are coated by sp2-, and sp3-bonded amorphous carbon and functional groups of carboxylic acids (e.g., carboxyl, carboxylate, methyl, and methylene), indicating the geosynthesis of organic compounds in deep hydrous fluids.	Carboxylic Acids	135-151	Sp3 transcription factor	Homo sapiens	82-85
31687364-4	2019	The expression of hydroxy-carboxylic acid receptors (HCA)1, HCA2 and HCA3 was detected by immunoblotting, flow cytometry, immunofluorescence and RT-PCR assays.	Carboxylic Acids	18-41	HCA1	Homo sapiens	53-58
31649709-9	2019	Expression analysis of key genes associated with ethylene biosynthesis (aminocyclopropane-1-carboxylic acid synthase and oxidase; ACS and ACO) and polyphenol oxidase (PPO) showed the potential for increased ethylene production and the mechanism for enhanced PPO-mediated browning.	Carboxylic Acids	72-107	1-aminocyclopropane-1-carboxylate oxidase 2	Malus domestica	121-141
31649709-9	2019	Expression analysis of key genes associated with ethylene biosynthesis (aminocyclopropane-1-carboxylic acid synthase and oxidase; ACS and ACO) and polyphenol oxidase (PPO) showed the potential for increased ethylene production and the mechanism for enhanced PPO-mediated browning.	Carboxylic Acids	72-107	polyphenol oxidase, chloroplastic	Malus domestica	167-170
31649709-9	2019	Expression analysis of key genes associated with ethylene biosynthesis (aminocyclopropane-1-carboxylic acid synthase and oxidase; ACS and ACO) and polyphenol oxidase (PPO) showed the potential for increased ethylene production and the mechanism for enhanced PPO-mediated browning.	Carboxylic Acids	72-107	polyphenol oxidase, chloroplastic	Malus domestica	258-261
31572413-6	2019	When we introduced transgene into the lht1 mutant, the transgenic expression of LHT2, but not of LHT3 or amino acid permease 5 (AAP5), restored the ACC resistance phenotype of the lht1 mutant.	Carboxylic Acids	148-151	lysine histidine transporter 1	Arabidopsis thaliana	180-184
31572413-8	2019	In support, when expressed in Xenopus laevis oocytes, both LHT1 and LHT2 exhibited ACC-transporting activity, inducing inward current upon addition of ACC.	Carboxylic Acids	83-86	lysine histidine transporter 1	Arabidopsis thaliana	59-63
31572413-3	2019	Recently, our genetic characterization of an ACC-resistant mutant with normal ethylene sensitivity revealed that lysine histidine transporter 1 (LHT1) functions as a transporter of ACC.	Carboxylic Acids	45-48	lysine histidine transporter 1	Arabidopsis thaliana	113-150
31572413-3	2019	Recently, our genetic characterization of an ACC-resistant mutant with normal ethylene sensitivity revealed that lysine histidine transporter 1 (LHT1) functions as a transporter of ACC.	Carboxylic Acids	181-184	lysine histidine transporter 1	Arabidopsis thaliana	113-150
31572413-8	2019	In support, when expressed in Xenopus laevis oocytes, both LHT1 and LHT2 exhibited ACC-transporting activity, inducing inward current upon addition of ACC.	Carboxylic Acids	83-86	lysine histidine transporter 2	Arabidopsis thaliana	68-72
31572413-4	2019	As amino acid transporters might have broad substrate specificity, we hypothesized that other amino acid transporters including LHT1 paralogs might have the ACC-transporter activity.	Carboxylic Acids	157-160	lysine histidine transporter 1	Arabidopsis thaliana	128-132
31572413-8	2019	In support, when expressed in Xenopus laevis oocytes, both LHT1 and LHT2 exhibited ACC-transporting activity, inducing inward current upon addition of ACC.	Carboxylic Acids	151-154	lysine histidine transporter 1	Arabidopsis thaliana	59-63
31572413-6	2019	When we introduced transgene into the lht1 mutant, the transgenic expression of LHT2, but not of LHT3 or amino acid permease 5 (AAP5), restored the ACC resistance phenotype of the lht1 mutant.	Carboxylic Acids	148-151	lysine histidine transporter 2	Arabidopsis thaliana	80-84
31572413-8	2019	In support, when expressed in Xenopus laevis oocytes, both LHT1 and LHT2 exhibited ACC-transporting activity, inducing inward current upon addition of ACC.	Carboxylic Acids	151-154	lysine histidine transporter 2	Arabidopsis thaliana	68-72
31268307-5	2019	Structure-activity relationship studies revealed that a free phenol group at C-6 and a carboxylic acid at C-9" were key features for dual PPARalpha/gamma agonism activity.	Carboxylic Acids	87-102	peroxisome proliferator activated receptor alpha	Homo sapiens	138-147
31649855-2	2019	Activation of the carboxylic group with the DCC-HOBt-DMAP protocol afforded a high yield of the OBt ester 4, that was next converted into the highly crystalline di-depsidic dimer 5 upon treatment with DMAP.	Carboxylic Acids	18-28	DCC netrin 1 receptor	Homo sapiens	44-47
31343885-1	2019	A novel one-pot reaction of carboxylic acids, ynol ethers, and m-CPBA for the synthesis of alpha-carbonyloxy esters in the presence of Ag2O is described.	Carboxylic Acids	28-44	anterior gradient 2, protein disulphide isomerase family member	Homo sapiens	135-138
32626377-0	2019	Scientific Opinion on Flavouring Group Evaluation 5, Revision 3 (FGE.05Rev3): Branched- and straight-chain unsaturated aldehydes, dienals, unsaturated and saturated carboxylic acids and related esters with saturated and unsaturated aliphatic alcohols and a phenylacetic acid related ester from chemical groups 1, 2, 3, 5 and 15.	Carboxylic Acids	165-181	sulfatase modifying factor 1	Homo sapiens	65-68
32626377-0	2019	Scientific Opinion on Flavouring Group Evaluation 5, Revision 3 (FGE.05Rev3): Branched- and straight-chain unsaturated aldehydes, dienals, unsaturated and saturated carboxylic acids and related esters with saturated and unsaturated aliphatic alcohols and a phenylacetic acid related ester from chemical groups 1, 2, 3, 5 and 15.	Carboxylic Acids	165-181	REV3 like, DNA directed polymerase zeta catalytic subunit	Homo sapiens	71-75
31268706-4	2019	Additional spectroscopic and X-ray absorption spectroscopy (XAS) studies show that Cu2+ is coordinated by two carboxylic acid groups and the single amine group on an appended side chain of GdL1 and forms a ternary complex with HSA (GdL1-Cu2+-HSA).	Carboxylic Acids	110-125	immunoglobulin kappa variable 1-35	Mus musculus	83-86
30742770-3	2019	To our knowledge, when in their neutral form, carboxylic acids are typically protonated in the syn conformation by default in classical molecular modeling packages, with no consideration of alternative conformations, though we are not aware of any careful examination of this topic.	Carboxylic Acids	46-62	synemin	Homo sapiens	95-98
30917761-0	2019	Kujigamberoic acid A, a carboxylic acid derivative of kujigamberol, has potent inhibitory activity against the degranulation of RBL-2H3 cells.	Carboxylic Acids	24-39	RB transcriptional corepressor like 2	Rattus norvegicus	128-133
31117358-1	2019	Acetyl-CoA synthetase (ACS) is a member of a large superfamily of enzymes that display diverse substrate specificities, with a common mechanism of catalyzing the formation of a thioester bond between Coenzyme A and a carboxylic acid, while hydrolyzing ATP to AMP and pyrophosphate.	Carboxylic Acids	217-232	acetyl-CoA synthetase	Arabidopsis thaliana	0-21
31117358-1	2019	Acetyl-CoA synthetase (ACS) is a member of a large superfamily of enzymes that display diverse substrate specificities, with a common mechanism of catalyzing the formation of a thioester bond between Coenzyme A and a carboxylic acid, while hydrolyzing ATP to AMP and pyrophosphate.	Carboxylic Acids	217-232	acetyl-CoA synthetase	Arabidopsis thaliana	23-26
31042061-5	2019	For Olfr558, we confirmed activation by previously reported ligands and identified 16 additional carboxylic acids that activated this OR.	Carboxylic Acids	97-113	olfactory receptor family 51 subfamily E member 1	Mus musculus	4-11
30927647-3	2019	It was found that the formation of carboxylic acids can be maximized at 190  C, 70 bar and under an inert atmosphere, with concentrations after 2 h of 29.0 g/l of oxalic acid, 1.8 g/L of malic acid, 10.0 g/L of lactic acid, 4.1 g/L of formic acid, 11.8 g/L of acetic acid and 3.4 g/L of propionic acid.	Carboxylic Acids	35-51	erythrocyte membrane protein band 4.1 like 2	Homo sapiens	224-229
30742770-4	2019	Here, we investigate the general belief that carboxylic acids should always be protonated in the syn conformation.	Carboxylic Acids	45-61	synemin	Homo sapiens	97-100
30872479-2	2019	Molecular dynamics simulations of FFAR1 with agonist removed demonstrated a major rearrangement of the polar and charged anchor point residues for the carboxylic acid moiety of the agonist in the interhelical site, which was associated with closure of a neighboring, solvent-exposed pocket between the extracellular poles of TM-I, TM-II, and TM-VII.	Carboxylic Acids	151-166	free fatty acid receptor 1	Homo sapiens	34-39
30926247-1	2019	Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition comparable to the corresponding parent compounds.	Carboxylic Acids	83-98	diacylglycerol O-acyltransferase 1	Mus musculus	41-46
30926247-1	2019	Previously disclosed benzimidazole-based DGAT1 inhibitors containing a cyclohexane carboxylic acid moiety suffer from isomerization at the alpha position of the carboxylic acid group, generating active metabolites which exhibit DGAT1 inhibition comparable to the corresponding parent compounds.	Carboxylic Acids	83-98	diacylglycerol O-acyltransferase 1	Mus musculus	228-233
30858027-4	2019	Further molecular docking studies revealed that the compound 19a formed a coordinate bond with the heme iron through the carboxylic acid moiety.	Carboxylic Acids	121-136	SLAM family member 7	Homo sapiens	61-64
30852903-0	2019	Bilayer Adsorption of Porphyrin Molecules Substituted with Carboxylic Acid atop the NN4A Network Revealed by STM and DFT.	Carboxylic Acids	59-74	sulfotransferase family 1A member 3	Homo sapiens	109-112
30787099-3	2019	The hydroxypropylamine moiety that is critical in emixustat"s inhibition of RPE65 is oxidatively deaminated to three major carboxylic acid metabolites that appear rapidly in plasma.	Carboxylic Acids	123-138	retinoid isomerohydrolase RPE65	Homo sapiens	76-81
30887991-1	2019	A general and selective method is developed that allows difunctionalization of terminal alkynes by a Cu(iii)-CF3 complex and a carboxylic acid regioselectively and with unusual syn-stereochemistry.	Carboxylic Acids	127-142	synemin	Homo sapiens	177-180
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Carboxylic Acids	175-191	carnosine dipeptidase 2	Homo sapiens	65-69
30715803-9	2019	The analysis of the crystal structure of human MDM2 in complex with the compound (R)-6a (carboxylic acid of the active (R)-5a compound) revealed the classical three-finger binding mode.	Carboxylic Acids	89-104	MDM2 proto-oncogene	Homo sapiens	47-51
30721697-3	2019	Aldehyde dehydrogenase 2 (ALDH2), one of 19 human ALDH isozymes, metabolizes endogenous and exogenous aldehydes to their respective carboxylic acids.	Carboxylic Acids	132-148	aldehyde dehydrogenase 2 family member	Homo sapiens	0-24
30721697-3	2019	Aldehyde dehydrogenase 2 (ALDH2), one of 19 human ALDH isozymes, metabolizes endogenous and exogenous aldehydes to their respective carboxylic acids.	Carboxylic Acids	132-148	aldehyde dehydrogenase 2 family member	Homo sapiens	26-31
30721697-3	2019	Aldehyde dehydrogenase 2 (ALDH2), one of 19 human ALDH isozymes, metabolizes endogenous and exogenous aldehydes to their respective carboxylic acids.	Carboxylic Acids	132-148	aldehyde dehydrogenase 2 family member	Homo sapiens	26-30
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Carboxylic Acids	175-191	cathepsin D	Homo sapiens	79-83
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Carboxylic Acids	175-191	carnosine dipeptidase 2	Homo sapiens	140-144
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Carboxylic Acids	175-191	cathepsin D	Homo sapiens	195-199
30884823-5	2019	Fourier Transform Infrared (FTIR) spectroscopy demonstrated that PepA inhibits CatD activity by occupying its active site; the OH bond from PepA interacts with a CO bond from carboxylic acids of CatD catalytic aspartate dyad, favoring the deprotonation of Asp33 and consequently inhibiting CatD.	Carboxylic Acids	175-191	cathepsin D	Homo sapiens	195-199
30802072-1	2019	Here we reported a method for Cu2+-catalyzed ortho-acyloxylation of either the C(sp2)-H or C(sp2)-X (X = Cl, Br) bond of aromatic amides with carboxylic acid, especially olefine acids, to obtain corresponding products in good yields up to 91%.	Carboxylic Acids	142-157	Sp2 transcription factor	Homo sapiens	79-84
30802072-1	2019	Here we reported a method for Cu2+-catalyzed ortho-acyloxylation of either the C(sp2)-H or C(sp2)-X (X = Cl, Br) bond of aromatic amides with carboxylic acid, especially olefine acids, to obtain corresponding products in good yields up to 91%.	Carboxylic Acids	142-157	Sp2 transcription factor	Homo sapiens	91-96
30530814-2	2019	However, for some cyanopyrrolidine dipeptidyl peptidase 4 (DPP-4) inhibitors (vildagliptin, anagliptin, and besigliptin, but not saxagliptin), the conversion of nitrile group into carboxylic acid is their major metabolic pathway in vivo.	Carboxylic Acids	180-195	dipeptidylpeptidase 4	Rattus norvegicus	35-57
30762343-1	2019	A Zr metal-organic framework (MOF) 1-CoCl3 has been synthesized by solvothermal reaction of ZrCl4 with a carboxylic acid-functionalized CoIII-PNNNP pincer complex H4(L-CoCl3) ([L-CoCl3]4- = [(2,6-(NHPAr2)2C6H3)CoCl3]4-, Ar = p-C6H4CO2-).	Carboxylic Acids	105-120	mitochondrially encoded cytochrome c oxidase III	Homo sapiens	136-141
30839290-0	2019	Carbonic anhydrase II in complex with carboxylic acid-based inhibitors.	Carboxylic Acids	38-53	carbonic anhydrase 2	Homo sapiens	0-21
30530814-2	2019	However, for some cyanopyrrolidine dipeptidyl peptidase 4 (DPP-4) inhibitors (vildagliptin, anagliptin, and besigliptin, but not saxagliptin), the conversion of nitrile group into carboxylic acid is their major metabolic pathway in vivo.	Carboxylic Acids	180-195	dipeptidylpeptidase 4	Rattus norvegicus	59-64
33855470-3	2019	Regarding lysozyme our results helped to understand its catalytic mechanism and the carboxylic acid functional groups involved.	Carboxylic Acids	84-99	lysozyme	Homo sapiens	10-18
33833470-3	2019	Due to the efficient charge separation in the coordination process of Pt(PEt3)2(OTf)2 with pyridine and carboxylic acid and the directionality of metal-coordination bonds, these cages were prepared in high isolated yields (more than 90%).	Carboxylic Acids	104-119	POU class 2 homeobox 2	Homo sapiens	70-85
30656327-1	2019	The reactions of a series of carboxylic acids with H2B(C6F5) SMe2 are shown to afford species of the form [RC(O)OB(C6F5)]2O, (R = Tol 1, Ph 2, C6F53, Me2BrC 4, Me 5) in 87-95% yields with the concurrent reduction of the carboxylic acid to the corresponding aldehyde.	Carboxylic Acids	29-45	H2B clustered histone 21	Homo sapiens	51-59
30656327-1	2019	The reactions of a series of carboxylic acids with H2B(C6F5) SMe2 are shown to afford species of the form [RC(O)OB(C6F5)]2O, (R = Tol 1, Ph 2, C6F53, Me2BrC 4, Me 5) in 87-95% yields with the concurrent reduction of the carboxylic acid to the corresponding aldehyde.	Carboxylic Acids	29-44	H2B clustered histone 21	Homo sapiens	51-59
30523648-1	2019	A previously unknown transformation of aldehydes, ketones, and carboxylic acid derivatives leads to the formation of substituted oxiranes, aziridines, and azirines as shown by DFT and MP2 computations.	Carboxylic Acids	63-78	tryptase pseudogene 1	Homo sapiens	184-187
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	gap junction protein alpha 1	Homo sapiens	77-81
30867823-11	2019	Targeted metabolomics analysis further revealed that mTORC1 activation affected the metabolism of purine, carboxylic acid, and niacin in RPE.	Carboxylic Acids	106-121	CREB regulated transcription coactivator 1	Mus musculus	53-59
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	cell division cycle 20	Homo sapiens	23-28
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	H2A.X variant histone	Homo sapiens	30-35
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	enolase 1	Homo sapiens	37-41
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	caveolin 1	Homo sapiens	86-90
30451256-0	2018	Spin-crossover compounds based on iron(ii) complexes of 2,6-bis(pyrazol-1-yl)pyridine (bpp) functionalized with carboxylic acid and ethyl carboxylic acid.	Carboxylic Acids	112-127	spindlin 1	Homo sapiens	0-4
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	actin beta	Homo sapiens	43-47
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	ISG15 ubiquitin like modifier	Homo sapiens	49-54
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	lysine acetyltransferase 2B	Homo sapiens	55-60
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	heterogeneous nuclear ribonucleoprotein D	Homo sapiens	62-68
30678426-6	2019	The top ten hub genes (CDC20, H2AFX, ENO1, ACTB, ISG15,KAT2B, HNRNPD, YWHAE, GJA1 and CAV1) were identified, which play important roles in critical signalingpathways that regulate the process of oxidation-reduction reaction and carboxylic acid metabolism.	Carboxylic Acids	228-243	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	70-75
31161516-1	2019	Tubulin tyrosine ligase (TTL) catalyzes the addition of tyrosine derivatives to the C-terminal carboxylic acid of proteins.	Carboxylic Acids	95-110	tubulin tyrosine ligase	Homo sapiens	0-23
31161516-1	2019	Tubulin tyrosine ligase (TTL) catalyzes the addition of tyrosine derivatives to the C-terminal carboxylic acid of proteins.	Carboxylic Acids	95-110	tubulin tyrosine ligase	Homo sapiens	25-28
30655940-4	2019	Most synthetic GPR40 agonists have a carboxylic acid headgroup, which may cause idiosyncratic toxicities, including drug-induced-liver-injury (DILI).	Carboxylic Acids	37-52	free fatty acid receptor 1	Homo sapiens	15-20
30682805-7	2019	It was concluded that the negatively charged carboxylic acid group found in LEVO is attracting positively charged fibronectin, which in turn is attracting the cell to adhere to the adsorbed proteins on the surface of the scaffold.	Carboxylic Acids	45-60	fibronectin 1	Homo sapiens	114-125
31332754-2	2019	The enzyme tubulin tyrosine ligase incorporates coumarin-amino acids to the terminal carboxylic acid of proteins containing a short peptidic recognition sequence called Tub-tag.	Carboxylic Acids	85-100	tubulin tyrosine ligase	Homo sapiens	11-34
31332754-2	2019	The enzyme tubulin tyrosine ligase incorporates coumarin-amino acids to the terminal carboxylic acid of proteins containing a short peptidic recognition sequence called Tub-tag.	Carboxylic Acids	85-100	TUB bipartite transcription factor	Homo sapiens	169-172
30220232-4	2018	The structural evolution of DAAO inhibitors is presented from simple carboxylic acid derivatives via small, planar compounds with carboxylic acid mimetics to extended compounds whose binding is possible owing to DAAO flexibility.	Carboxylic Acids	69-84	D-amino acid oxidase	Homo sapiens	28-32
30109916-0	2018	Origin of Nb2 O5 Lewis Acid Catalysis for Activation of Carboxylic Acids in the Presence of a Hard Base.	Carboxylic Acids	56-72	contactin 5	Homo sapiens	10-13
30109916-1	2018	The Nb2 O5 surface catalyzes the amidation of carboxylic acids with amines through Nb5+ Lewis acid activation of the C=O group.	Carboxylic Acids	46-62	contactin 5	Homo sapiens	4-7
30109916-2	2018	In this work, DFT calculations were applied to theoretically investigate the C=O bond activation of a model carboxylic acid (acetic acid) on theta-Al2 O3 (110), anatase TiO2 (101), and T-Nb2 O5 (100) surfaces.	Carboxylic Acids	108-123	contactin 5	Homo sapiens	187-190
30308036-1	2018	BACKGROUND: Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes aldehydes to their corresponding carboxylic acids.	Carboxylic Acids	114-130	aldehyde dehydrogenase 1 family member A1	Homo sapiens	12-38
30308036-1	2018	BACKGROUND: Aldehyde dehydrogenase 1A1 (ALDH1A1) encodes an enzyme that oxidizes aldehydes to their corresponding carboxylic acids.	Carboxylic Acids	114-130	aldehyde dehydrogenase 1 family member A1	Homo sapiens	40-47
30220232-4	2018	The structural evolution of DAAO inhibitors is presented from simple carboxylic acid derivatives via small, planar compounds with carboxylic acid mimetics to extended compounds whose binding is possible owing to DAAO flexibility.	Carboxylic Acids	130-145	D-amino acid oxidase	Homo sapiens	28-32
29750408-3	2018	To date, several non-covalent small-molecule Keap1-Nrf2 inhibitors have been identified; however, many of them contain carboxylic acids and are rather large in size, which likely prevents or decreases CNS permeability.	Carboxylic Acids	119-135	kelch like ECH associated protein 1	Homo sapiens	45-50
30082428-0	2018	Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilon and Reveal Mechanisms for Selective Inhibition.	Carboxylic Acids	0-15	TANK binding kinase 1	Homo sapiens	73-77
30082428-0	2018	Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKepsilon and Reveal Mechanisms for Selective Inhibition.	Carboxylic Acids	0-15	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	82-92
30082428-4	2018	Herein we report crystal structures of TBK1 in complex with amlexanox and a series of analogs that modify its carboxylic acid moiety.	Carboxylic Acids	110-125	TANK binding kinase 1	Homo sapiens	39-43
30082428-5	2018	Removal of the carboxylic acid or mutation of the adjacent Thr156 residue significantly reduces potency toward TBK1, whereas conversion to a short amide or ester nearly abolishes the inhibitory effects.	Carboxylic Acids	15-30	TANK binding kinase 1	Homo sapiens	111-115
29750408-3	2018	To date, several non-covalent small-molecule Keap1-Nrf2 inhibitors have been identified; however, many of them contain carboxylic acids and are rather large in size, which likely prevents or decreases CNS permeability.	Carboxylic Acids	119-135	NFE2 like bZIP transcription factor 2	Homo sapiens	51-55
29799151-2	2018	The ability of the carboxylic acids to form strong hydrogen bonds with the PIL ion pair leads to an azeotropic composition richer in the acid component.	Carboxylic Acids	19-35	serpin family A member 2 (gene/pseudogene)	Homo sapiens	75-78
29932631-4	2018	Consistent with a model of active site Zn2+ chelation by the carboxylic acid present in tianeptine, newly synthesized analogues containing either a hydroxamic acid or ortho-aminoanilide exhibited increased potency and selectivity among the HDAC family.	Carboxylic Acids	61-76	histone deacetylase 9	Homo sapiens	240-244
29980364-4	2018	Biological assay results showed that methyl sulfone compounds 2 and 7 were the most potent COX inhibitors of this series and best than the corresponding carboxylic acids (methyl sulfone 2: IC50 COX-1 = 0.04 and COX-2 = 0.10 muM, and naproxen: IC50 COX-1 = 11.3 and COX-2 = 3.36 muM).	Carboxylic Acids	153-169	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	194-199
30197652-6	2018	Nitriles are converted by specific enzymes, nitrilases (NIT1-3), to their corresponding carboxylic acids.	Carboxylic Acids	88-104	nitrilase 1	Arabidopsis thaliana	56-60
30009780-6	2018	These results suggest that tubulin regulates the activation of AR through a direct interaction which can be controlled with phenolic derivates of carboxylic acids.	Carboxylic Acids	146-162	aldo-keto reductase family 1 member B	Homo sapiens	63-65
30022657-6	2018	After that, the capture monoclonal antibody for IL-6, IL-1beta, and TNF-alpha was modified to the carboxylic acid terminated sensing interface.	Carboxylic Acids	98-113	interleukin 6	Homo sapiens	48-52
30022657-6	2018	After that, the capture monoclonal antibody for IL-6, IL-1beta, and TNF-alpha was modified to the carboxylic acid terminated sensing interface.	Carboxylic Acids	98-113	interleukin 1 beta	Homo sapiens	54-62
30022657-6	2018	After that, the capture monoclonal antibody for IL-6, IL-1beta, and TNF-alpha was modified to the carboxylic acid terminated sensing interface.	Carboxylic Acids	98-113	tumor necrosis factor	Homo sapiens	68-77
30036059-6	2018	Inhibition of de novo lipogenesis with representative parent carboxylic acids and their respective acyl glucuronide conjugates in human hepatocytes demonstrated their propensity to activate cellular AMPK.	Carboxylic Acids	61-77	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	199-203
29980364-4	2018	Biological assay results showed that methyl sulfone compounds 2 and 7 were the most potent COX inhibitors of this series and best than the corresponding carboxylic acids (methyl sulfone 2: IC50 COX-1 = 0.04 and COX-2 = 0.10 muM, and naproxen: IC50 COX-1 = 11.3 and COX-2 = 3.36 muM).	Carboxylic Acids	153-169	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	211-216
29980364-4	2018	Biological assay results showed that methyl sulfone compounds 2 and 7 were the most potent COX inhibitors of this series and best than the corresponding carboxylic acids (methyl sulfone 2: IC50 COX-1 = 0.04 and COX-2 = 0.10 muM, and naproxen: IC50 COX-1 = 11.3 and COX-2 = 3.36 muM).	Carboxylic Acids	153-169	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	248-253
29980364-4	2018	Biological assay results showed that methyl sulfone compounds 2 and 7 were the most potent COX inhibitors of this series and best than the corresponding carboxylic acids (methyl sulfone 2: IC50 COX-1 = 0.04 and COX-2 = 0.10 muM, and naproxen: IC50 COX-1 = 11.3 and COX-2 = 3.36 muM).	Carboxylic Acids	153-169	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	265-270
29859380-0	2018	Carboxylic acid derivatives display potential selectivity for human histone deacetylase 6: Structure-based virtual screening, molecular docking and dynamics simulation studies.	Carboxylic Acids	0-15	histone deacetylase 6	Homo sapiens	68-89
29570292-3	2018	One such approach arose from the observation that carboxylic acid-based intermediates employed in our discovery efforts retained high MAP4K4 inhibitory potency and were devoid of the TDI risk.	Carboxylic Acids	50-65	mitogen-activated protein kinase kinase kinase kinase 4	Homo sapiens	134-140
29881969-7	2018	In samples from a Saharan Dust event and in samples with the lowest and the highest OCsec, ATR-FTIR analysis allowed us to identify organic functional groups including the non-acid organic hydroxyl C-OH group (e.g., sugars, anhydrosugars, and polyols), carbonyl C=O group, carboxylic acid COOH group, aromatic and aliphatic unsaturated C=C-H group, aliphatic saturated C-C-H group, and amine NH2 group.	Carboxylic Acids	273-288	ATR serine/threonine kinase	Homo sapiens	91-94
29774983-1	2018	The mechanism of the Ni0 -catalyzed reductive carboxylation reaction of C(sp2 )-O and C(sp3 )-O bonds in aromatic esters with CO2 to access valuable carboxylic acids was comprehensively studied by using DFT calculations.	Carboxylic Acids	149-165	Sp2 transcription factor	Homo sapiens	72-77
29679102-8	2018	This review concentrates on the physiological roles, regulation mechanisms, and harnessing strategies of Jen and AcpA orthologs in fungi, which provide potential clues for the biotechnological production of short-chain carboxylic acids with high efficiency.	Carboxylic Acids	219-235	proteinase 3	Homo sapiens	113-117
29505165-4	2018	Herein, the synthesis of a perthiatriarylmethyl (PST) radical and its dendritic derivatives, PST-TA and PST-NA, in which PST is covalently linked with dendrons containing three (TA) and nine (NA) carboxylic acids, respectively.	Carboxylic Acids	196-212	sulfotransferase family 1A member 1	Homo sapiens	49-52
29505165-4	2018	Herein, the synthesis of a perthiatriarylmethyl (PST) radical and its dendritic derivatives, PST-TA and PST-NA, in which PST is covalently linked with dendrons containing three (TA) and nine (NA) carboxylic acids, respectively.	Carboxylic Acids	196-212	sulfotransferase family 1A member 1	Homo sapiens	93-96
29505165-4	2018	Herein, the synthesis of a perthiatriarylmethyl (PST) radical and its dendritic derivatives, PST-TA and PST-NA, in which PST is covalently linked with dendrons containing three (TA) and nine (NA) carboxylic acids, respectively.	Carboxylic Acids	196-212	sulfotransferase family 1A member 1	Homo sapiens	93-96
29505165-4	2018	Herein, the synthesis of a perthiatriarylmethyl (PST) radical and its dendritic derivatives, PST-TA and PST-NA, in which PST is covalently linked with dendrons containing three (TA) and nine (NA) carboxylic acids, respectively.	Carboxylic Acids	196-212	sulfotransferase family 1A member 1	Homo sapiens	93-96
29670058-0	2018	Effective Conversion of Amide to Carboxylic Acid on Polymers of Intrinsic Microporosity (PIM-1) with Nitrous Acid.	Carboxylic Acids	33-48	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	89-94
29961803-3	2018	The results unexpectedly reveal that KDM6B accepts multiple Nepsilon-alkylated lysine analogues, forming alcohol, aldehyde and carboxylic acid products.	Carboxylic Acids	127-142	lysine demethylase 6B	Homo sapiens	37-42
29597170-3	2018	C (5)-substitution of the benzimidazole ring of BRP-7 by carboxylic acid and its bioisosteres provided compounds, exemplified by 57 that potently suppress LT formation (IC50 = 0.05 muM) by targeting FLAP along with inhibition of mPGES-1 (IC50 = 0.42 muM).	Carboxylic Acids	57-72	arachidonate 5-lipoxygenase activating protein	Homo sapiens	199-203
29597170-3	2018	C (5)-substitution of the benzimidazole ring of BRP-7 by carboxylic acid and its bioisosteres provided compounds, exemplified by 57 that potently suppress LT formation (IC50 = 0.05 muM) by targeting FLAP along with inhibition of mPGES-1 (IC50 = 0.42 muM).	Carboxylic Acids	57-72	prostaglandin E synthase	Mus musculus	229-236
29496875-4	2018	These catalysts transform a wide range of 1,4,2-dioxazol-5-ones, carbonylnitrene precursors easily accessible from carboxylic acids, into the corresponding gamma-lactams via sp3 and sp2 C-H amidation with exceptional selectivity.	Carboxylic Acids	115-131	Sp3 transcription factor	Homo sapiens	174-177
29644551-0	2018	Lipase catalyzed epoxidation of fatty acid methyl esters derived from unsaturated vegetable oils in absence of carboxylic acid.	Carboxylic Acids	111-126	PAN0_003d1715	Moesziomyces antarcticus	0-6
29421555-4	2018	We found that by tuning the initial protonation state of carboxylic acid residues of HA in a covalently crosslinked hydrogel modulate BMP-2 release at physiological pH by minimizing the electrostatic repulsion and maximizing the Van der Waals interactions.	Carboxylic Acids	57-72	bone morphogenetic protein 2	Homo sapiens	134-139
29509424-2	2018	The btp ligand, H3L, adopts a three-dimensional hydrogen bonding network in the crystalline state through a combination of carboxylic acid dimer and syn-anti-btp/carboxylic acid hydrogen bonding synthons.	Carboxylic Acids	162-177	synemin	Homo sapiens	149-152
29277042-11	2018	Moreover, Fe-Cu-MCM-41 showed excellent catalytic performance in suppressing the accumulation of carboxylic acid, especially for oxalic acid.	Carboxylic Acids	97-112	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	16-19
29496875-4	2018	These catalysts transform a wide range of 1,4,2-dioxazol-5-ones, carbonylnitrene precursors easily accessible from carboxylic acids, into the corresponding gamma-lactams via sp3 and sp2 C-H amidation with exceptional selectivity.	Carboxylic Acids	115-131	Sp2 transcription factor	Homo sapiens	182-185
29541369-0	2018	Linker Variation and Structure-Activity Relationship Analyses of Carboxylic Acid-based Small Molecule STAT3 Inhibitors.	Carboxylic Acids	65-80	signal transducer and activator of transcription 3	Homo sapiens	102-107
29258772-2	2018	Most of the GPR40 agonists in the literature have a carboxylic acid functional group, which may pose a risk for idiosyncratic drug toxicity.	Carboxylic Acids	52-67	free fatty acid receptor 1	Rattus norvegicus	12-17
29409752-6	2018	A co-crystal structure of CSR35 with RIPK2 revealed a resolved activation loop with an ionic interaction between the carboxylic acid installed in the inhibitor and the side-chain of Lys169.	Carboxylic Acids	117-132	receptor interacting serine/threonine kinase 2	Homo sapiens	37-42
29258772-3	2018	A novel series of GPR40 agonists containing a tetrazole as a carboxylic acid bioisostere was identified.	Carboxylic Acids	61-76	free fatty acid receptor 1	Rattus norvegicus	18-23
28756656-3	2017	Here, we report a strategy for CNS-selective distribution of the carboxylic acid containing thyromimetic sobetirome using prodrugs targeted to fatty-acid amide hydrolase (FAAH), which is expressed in the brain.	Carboxylic Acids	65-80	fatty acid amide hydrolase	Mus musculus	171-175
29404991-2	2018	Here, the natural enzyme tubulin tyrosine ligase incorporates noncanonical tyrosine derivatives to the terminal carboxylic acid of proteins containing a 14-amino acid recognition sequence called Tub-tag.	Carboxylic Acids	112-127	TUB bipartite transcription factor	Homo sapiens	195-198
28892705-1	2017	In this study, the effect of reduced hydrogen partial pressure (PH2) on the generation of carboxylic acids from acidogenic fermentation of glucose was investigated.	Carboxylic Acids	90-106	polyhomeotic homolog 2	Homo sapiens	64-67
28892705-5	2017	In addition, decreasing PH2 led to more carbon flow to carboxylic acids.	Carboxylic Acids	55-71	polyhomeotic homolog 2	Homo sapiens	24-27
28892705-7	2017	This study demonstrated that decreasing PH2 could increase the production of carboxylic acids, especially under the strategy of enhancing homoacetogenesis.	Carboxylic Acids	77-93	polyhomeotic homolog 2	Homo sapiens	40-43
29719676-6	2018	However, depending on reaction conditions and substrate identity (carboxylic acid, amide or carbamate), the internal nucleophiles may close with a strong net preference for either syn or anti addition relative to the Cl atom.	Carboxylic Acids	66-81	synemin	Homo sapiens	180-183
29181462-5	2017	The ROS-ARP is designed to change the hydrophilicity by ROS, revealing a carboxylic acid, which also catalyzes ketal hydrolysis along the polymer backbone.	Carboxylic Acids	73-88	mesencephalic astrocyte derived neurotrophic factor	Homo sapiens	8-11
29096096-2	2017	We previously reported a novel series of triazole-based uracil derivatives bearing aliphatic carboxylic acids with potent DPP-4 inhibitory activities in vitro, but these compounds showed poor hypoglycemic effects in vivo.	Carboxylic Acids	93-109	dipeptidylpeptidase 4	Mus musculus	122-127
29143006-3	2017	In contrast, the control molecule PDI-2, containing an ester group does not show aggregation even in decalin, indicating that H-bonding among the carboxylic acid is primarily responsible for H-aggregation, which is further verified by the FT-IR study.	Carboxylic Acids	146-161	peptidyl arginine deiminase 2	Homo sapiens	34-39
28627572-1	2017	Esterification of (4-hydroxyphenyl)diphenylphosphine, coordinated to the [Ru(eta6-p-cymene)Cl2] fragment, allows a series of bioactive carboxylic acids to be introduced directly into the organometallic molecule.	Carboxylic Acids	135-151	endothelin receptor type A	Homo sapiens	77-80
29022639-6	2017	In addition, since PAA has abundant free carboxylic acid groups, the PAA-GOx forms covalent bonds with the GO-PEI to curtail the leaching-out of GOx molecules.	Carboxylic Acids	41-56	hydroxyacid oxidase 1	Homo sapiens	73-76
29022639-6	2017	In addition, since PAA has abundant free carboxylic acid groups, the PAA-GOx forms covalent bonds with the GO-PEI to curtail the leaching-out of GOx molecules.	Carboxylic Acids	41-56	hydroxyacid oxidase 1	Homo sapiens	145-148
28532282-2	2017	First, PyHES was prepared via hydrophobic modification of hydroxyl groups in hydroxyethyl starch (HES) with propynylglycidyl ether (PGE), and then pH-responsive carboxylic acid group was connected to propynyl group via thiol-yne click reaction with NAC.	Carboxylic Acids	161-176	synuclein alpha	Homo sapiens	249-252
28831468-6	2017	Lignin functionalized with short chain carboxylic acids interacts with ligands directed at the norepinephrine transporter (NET), suggesting applications in sequestration of neuroactive compounds.	Carboxylic Acids	39-55	solute carrier family 6 member 2	Homo sapiens	95-121
28857471-0	2017	Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.	Carboxylic Acids	90-105	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	27-52
28809966-2	2017	Dual salt bridge formation between imidazole side chains and carboxylic acids resulted in the preorganization of the uracil monomers and the preferential formation of the cis-syn photodimer.	Carboxylic Acids	61-77	synemin	Homo sapiens	175-178
28787164-0	2017	Co(II)-Catalyzed Regioselective Cross-Dehydrogenative Coupling of Aryl C-H Bonds with Carboxylic Acids.	Carboxylic Acids	86-102	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-6
28722301-4	2017	The zinc-binding MMP-13 inhibitors contain a small set of zinc-binding groups (ZBGs), including hydroxamic acid, pyrimidinetrione, reversed hydroxamic acid and hydantoin, carboxylic acid, 1,2,4,-triazole, and 1,2,4,-triazolone.	Carboxylic Acids	171-186	matrix metallopeptidase 13	Homo sapiens	17-23
28483279-7	2017	Our results showed that the cyclization involving a C-terminal carboxylic acid (head-to-tail or side chain-to-tail) led to compounds with significantly diminished inhibitory potency towards PACE4, indicating that an appropriate balance between rigidity and flexibility of the structure is necessary to allow the optimal binding with the enzyme.	Carboxylic Acids	63-78	proprotein convertase subtilisin/kexin type 6	Homo sapiens	190-195
28775293-1	2017	Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite.	Carboxylic Acids	76-91	carboxylesterase 1	Homo sapiens	0-18
28775293-1	2017	Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite.	Carboxylic Acids	76-91	carboxylesterase 1	Homo sapiens	20-24
28657322-1	2017	Copper-catalyzed ortho-acyloxylation of the sp2 C-H bond of aryl amides with carboxylic acids is reported.	Carboxylic Acids	77-93	Sp2 transcription factor	Homo sapiens	44-47
28539218-2	2017	However, most existing PPAR ligands contain a carboxylic acid (CA) or thiazolidinedione (TZD) structure (acidic head group) that is essential for activity.	Carboxylic Acids	46-61	peroxisome proliferator activated receptor alpha	Homo sapiens	23-27
28540938-1	2017	A Rh(iii)-catalyzed C-H activation followed by conjugate addition to maleimides, using carboxylic acid as a traceless/deciduous directing group, to formally furnish a Csp2-Csp3 bond is presented.	Carboxylic Acids	87-102	regulator of calcineurin 2	Homo sapiens	167-171
28608694-6	2017	In the case of the analogous complex 1b bearing a more mobile distal strap, one of the carboxylic acid groups binds the iron(II) cation, leading to a six-coordinate ferrous complex.	Carboxylic Acids	87-102	serine/threonine kinase receptor associated protein	Homo sapiens	69-74
28746182-4	2017	This study aimed to investigate the effects of plumbagin-loaded prostate-specific membrane antigen (PSMA) aptamer-targeted poly D,L-lactic-co-glycolic acid-b-polyethylene glycol (PLGA-PEG) nanoparticles (NPs) on prostate cancer (PCa) in vitro.PLGA-PEG with a terminal carboxylic acid group (PLGA-PEG-COOH) was synthesized, and plumbagin was loaded on PLGA-PEG-COOH NPs using the nanoprecipitation method and characterized by field emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), and laser light scattering.	Carboxylic Acids	268-283	folate hydrolase 1	Homo sapiens	64-98
28746182-4	2017	This study aimed to investigate the effects of plumbagin-loaded prostate-specific membrane antigen (PSMA) aptamer-targeted poly D,L-lactic-co-glycolic acid-b-polyethylene glycol (PLGA-PEG) nanoparticles (NPs) on prostate cancer (PCa) in vitro.PLGA-PEG with a terminal carboxylic acid group (PLGA-PEG-COOH) was synthesized, and plumbagin was loaded on PLGA-PEG-COOH NPs using the nanoprecipitation method and characterized by field emission scanning electron microscopy (SEM), transmission electron microscopy (TEM), and laser light scattering.	Carboxylic Acids	268-283	folate hydrolase 1	Homo sapiens	100-104
28686585-6	2017	Here we describe a detailed protocol based on covalent binding of nucleophilic groups on Wnt proteins to activated carboxylic acid (COOH) or glutaraldehyde (COH) groups functionalized on synthetic surfaces.	Carboxylic Acids	115-130	Wnt family member 3A	Homo sapiens	89-92
28462834-3	2017	X-ray crystallography shows that the 1,2,3-triazol-4-one/ol acts as a carboxylic acid isostere, making a bi-dentate interaction with an arginine residue of Sortilin, an interaction which has not been previously characterised for this heterocycle.	Carboxylic Acids	70-85	sortilin 1	Homo sapiens	156-164
28266184-3	2017	The beta-1,3-glucan-complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (lambda>610 nm) than other beta-1,3-glucan-complexed fullerene derivatives.	Carboxylic Acids	58-73	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	4-12
28266184-4	2017	This result suggests that carboxylic acid moieties in the complex enhance the binding affinity with beta-1,3-glucan receptors on the surface of macrophages when the beta-1,3-glucan is recognized.	Carboxylic Acids	26-41	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	100-108
28266184-3	2017	The beta-1,3-glucan-complexed fullerene derivative with a carboxylic acid was found to have higher photodynamic activity toward macrophages under visible-light irradiation (lambda>610 nm) than other beta-1,3-glucan-complexed fullerene derivatives.	Carboxylic Acids	58-73	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	202-210
28266184-4	2017	This result suggests that carboxylic acid moieties in the complex enhance the binding affinity with beta-1,3-glucan receptors on the surface of macrophages when the beta-1,3-glucan is recognized.	Carboxylic Acids	26-41	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	165-173
28259841-2	2017	However, efforts to prepare small-molecule aldose reductase inhibitors (ARIs) have mostly yielded carboxylic acids with rather poor pharmacokinetics.	Carboxylic Acids	98-114	aldo-keto reductase family 1 member B1	Rattus norvegicus	43-59
27862978-0	2017	ABCC3 Polymorphisms and mRNA Expression Influence the Concentration of a Carboxylic Acid Metabolite in Patients on Clopidogrel and Aspirin Therapy.	Carboxylic Acids	73-88	ATP binding cassette subfamily C member 3	Homo sapiens	0-5
27862978-4	2017	We investigated the relationship of ABC-type efflux subfamily C member 3 (ABCC3) polymorphisms and mRNA expression with plasma concentrations of clopidogrel, salicylic acid (SA) and a carboxylic acid metabolite (CAM).	Carboxylic Acids	184-199	ATP binding cassette subfamily C member 3	Homo sapiens	74-79
28219011-1	2017	Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes the NAD+-dependent oxidation of aldehydes to their respective carboxylic acids.	Carboxylic Acids	142-158	aldehyde dehydrogenase 2 family member	Homo sapiens	0-24
28225218-5	2017	Finally, the bioconjugation ability of fluorescent derivatives bearing a free carboxylic acid was demonstrated through the covalent labeling of a model protein, namely, bovine serum albumin.	Carboxylic Acids	78-93	albumin	Homo sapiens	176-189
28254166-0	2017	Discovery of novel BTK inhibitors with carboxylic acids.	Carboxylic Acids	39-55	Bruton tyrosine kinase	Homo sapiens	19-22
28299936-0	2017	Development of Decarboxylative Cyanation Reactions for C-13/C-14 Carboxylic Acid Labeling Using an Electrophilic Cyanating Reagent.	Carboxylic Acids	65-80	homeobox C13	Homo sapiens	55-59
28254166-1	2017	We report the design and synthesis of a series of novel Bruton"s Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket.	Carboxylic Acids	105-120	Bruton tyrosine kinase	Homo sapiens	56-80
28219011-1	2017	Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes the NAD+-dependent oxidation of aldehydes to their respective carboxylic acids.	Carboxylic Acids	142-158	aldehyde dehydrogenase 2 family member	Homo sapiens	26-31
28254166-1	2017	We report the design and synthesis of a series of novel Bruton"s Tyrosine Kinase (BTK) inhibitors with a carboxylic acid moiety in the ribose pocket.	Carboxylic Acids	105-120	Bruton tyrosine kinase	Homo sapiens	82-85
28219011-1	2017	Aldehyde dehydrogenase 2 (ALDH2), one of 19 ALDH superfamily members, catalyzes the NAD+-dependent oxidation of aldehydes to their respective carboxylic acids.	Carboxylic Acids	142-158	aldehyde dehydrogenase 1 family member A1	Homo sapiens	26-30
28126414-1	2017	Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the hydrolysis of ester- or amide-containing compounds into the corresponding alcohols and carboxylic acids.	Carboxylic Acids	168-184	carboxylesterase 1	Homo sapiens	10-27
32625434-0	2017	Scientific Opinion on Flavouring Group Evaluation 7, Revision 5 (FGE.07Rev5): saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids from chemical group 5.	Carboxylic Acids	214-230	sulfatase modifying factor 1	Homo sapiens	65-68
28512568-4	2017	The carboxylic acid group of ACM forms theacid-amide dimer three-point synthon R32(9)R22(8)R32(9) with three different syn amides (VLM, 2HP and caprolactam).	Carboxylic Acids	4-19	synemin	Homo sapiens	71-74
28126414-1	2017	Mammalian carboxylesterases (CEs) are important serine hydrolases catalyzing the hydrolysis of ester- or amide-containing compounds into the corresponding alcohols and carboxylic acids.	Carboxylic Acids	168-184	cat eye syndrome chromosome region	Homo sapiens	29-32
27895112-1	2017	The main route of elimination of vildagliptin, which is an inhibitor of dipeptidyl peptidase-4 (DPP-4), in humans is cyano group hydrolysis to produce a carboxylic acid metabolite M20.7.	Carboxylic Acids	153-168	dipeptidyl peptidase 4	Homo sapiens	96-101
28112924-2	2017	The initial pyrrolidine hit was modified by moving the position of the carboxylic acid, a key pharmacophore for GPR40.	Carboxylic Acids	71-86	free fatty acid receptor 1	Homo sapiens	112-117
28112925-0	2017	Highly Potent Non-Carboxylic Acid Autotaxin Inhibitors Reduce Melanoma Metastasis and Chemotherapeutic Resistance of Breast Cancer Stem Cells.	Carboxylic Acids	18-33	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	34-43
28128371-1	2017	We report herein the efficient hydro-oxycarbonylation of symmetrical and unsymmetrical internal alkynes with carboxylic acids in water at 60  C, employing the catalytic system [AuCl(PPh3)]/AgOAc (5 mol%).	Carboxylic Acids	109-125	caveolin 1	Homo sapiens	182-186
27987935-3	2017	In this paper, near-infrared (NIR) photoluminescent Ag2S QDs capped by long-chain carboxylic acid were synthesized and then conjugated with CS via esterification reaction.	Carboxylic Acids	82-97	angiotensin II receptor type 1	Homo sapiens	52-56
28085282-1	2017	In the presence of catalytic amounts of the Au(I) cation [Au(PPh3)]+, a large variety of (Z)-beta-iodoenol esters (39 examples) could be synthesized under mild reaction conditions through the regio- and stereospecific intermolecular addition of carboxylic acids to iodoalkynes.	Carboxylic Acids	245-261	caveolin 1	Homo sapiens	61-65
32625258-0	2017	Scientific Opinion on Flavouring Group Evaluation 63, Revision 3 (FGE.63Rev3): aliphatic secondary alcohols, ketones and related esters evaluated by JECFA (59th and 69th meetings) structurally related to saturated and unsaturated aliphatic secondary alcohols, ketones and esters of secondary alcohols and saturated linear or branched-chain carboxylic acids evaluated by EFSA in FGE.07Rev4.	Carboxylic Acids	340-356	sulfatase modifying factor 1	Homo sapiens	66-69
27966272-1	2017	A PdII -catalyzed 2:1 coupling reaction of alkynylbenziodoxole with carboxylic acid to afford (alk-1-en-3-ynyl)benziodoxole, which is efficiently promoted by an octahydrophenazine ligand, is reported.	Carboxylic Acids	68-83	secretory leukocyte peptidase inhibitor	Homo sapiens	95-100
31961510-3	2017	The design of a B12 complex for the hybridization with TiO2 was simple and straightforward-cobyrinic acid, having seven carboxylic groups derived from naturally occurring B12 is stably immobilized on the TiO2 .	Carboxylic Acids	120-130	NADH:ubiquinone oxidoreductase subunit B3	Homo sapiens	16-19
27989121-4	2017	Here, bond length analysis of atomic (1.15-0.98 A) resolution X-ray crystal structures of the human protein DJ-1 and its bacterial homologue, YajL, was used to determine the protonation states of H-bonded carboxylic acids.	Carboxylic Acids	205-221	Parkinsonism associated deglycase	Homo sapiens	100-112
27916468-6	2017	Four compounds; diphenylthiazole glycine derivatives (15a, 15b) and diphenylimidazolo acetic acid derivatives (19a, 19b), which possess carboxylic acid group exhibited significant activity and selectivity against COX-1 over COX-2.	Carboxylic Acids	136-151	prostaglandin-endoperoxide synthase 1	Homo sapiens	213-218
27916468-6	2017	Four compounds; diphenylthiazole glycine derivatives (15a, 15b) and diphenylimidazolo acetic acid derivatives (19a, 19b), which possess carboxylic acid group exhibited significant activity and selectivity against COX-1 over COX-2.	Carboxylic Acids	136-151	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	224-229
27933999-3	2016	This DARP protocol employs low loadings of commercially available catalyst components, Pd2(dba)3 CHCl3 (0.5 mol%) and P(2-MeOPh)3 (2 mol%), sterically tuned carboxylic acid additives, and an environmentally friendly solvent, 2-methyltetrahydrofuran.	Carboxylic Acids	157-172	ankyrin repeat domain 23	Homo sapiens	5-9
27933999-3	2016	This DARP protocol employs low loadings of commercially available catalyst components, Pd2(dba)3 CHCl3 (0.5 mol%) and P(2-MeOPh)3 (2 mol%), sterically tuned carboxylic acid additives, and an environmentally friendly solvent, 2-methyltetrahydrofuran.	Carboxylic Acids	157-172	PAF1 homolog, Paf1/RNA polymerase II complex component	Homo sapiens	87-90
27827500-0	2016	NBS/DBU mediated one-pot synthesis of alpha-acyloxyketones from benzylic secondary alcohols and carboxylic acids.	Carboxylic Acids	96-112	nibrin	Homo sapiens	0-3
27196064-1	2016	The major metabolic pathway of clopidogrel is conversion to carboxylic acid by an esterase (CES1), forming clopidogrelic acid (SR26334) that is inactive.	Carboxylic Acids	60-75	carboxylesterase 1	Homo sapiens	92-96
27827500-1	2016	A simple and efficient one-pot NBS/DBU-mediated method has been developed for the synthesis of alpha-acyloxyketones from various benzylic secondary alcohols and carboxylic acids.	Carboxylic Acids	161-177	nibrin	Homo sapiens	31-34
27624080-0	2016	LAT1 activity of carboxylic acid bioisosteres: Evaluation of hydroxamic acids as substrates.	Carboxylic Acids	17-32	solute carrier family 7 member 5	Homo sapiens	0-4
27622746-3	2016	Various PPAR agonists have been developed, but most of them contain a carboxylic acid (CA) or thiazolidinedione (TZD) moiety, which is essential for the activity.	Carboxylic Acids	70-85	peroxisome proliferator activated receptor alpha	Homo sapiens	8-12
27435630-3	2016	On the one hand, comparative studies of the behaviour of DPPC monolayers in the presence or absence of PPH dendrimers in the subphase showed differences in the phase transitions, highlighting interactions between both dendrimers and phospholipid monolayers, with a larger incidence for the carboxylic acid capped dendrimer (negative control), validating its cellular toxicity.	Carboxylic Acids	290-305	enolase 1	Homo sapiens	103-106
27421777-0	2016	JWH-018 omega-OH, a shared hydroxy metabolite of the two synthetic cannabinoids JWH-018 and AM-2201, undergoes oxidation by alcohol dehydrogenase and aldehyde dehydrogenase enzymes in vitro forming the carboxylic acid metabolite.	Carboxylic Acids	202-217	aldo-keto reductase family 1 member A1	Homo sapiens	124-145
27647900-4	2016	Herein, we used the mild, highly efficient amidation reaction between alkylamine and N-hydroxysuccinimide-activated carboxylic acid to link the pendent amino functional groups of a rhomboidal metallacycle 10 to give metallacycle-cored polymers P1 and P2, which further yielded nanoparticles at low concentration and transformed into network structures as the concentration increased.	Carboxylic Acids	116-131	crystallin gamma F, pseudogene	Homo sapiens	244-253
27460349-0	2016	A Cu(ii) MOF with a flexible bifunctionalised terpyridine as an efficient catalyst for the single-pot hydrocarboxylation of cyclohexane to carboxylic acid in water/ionic liquid medium.	Carboxylic Acids	139-154	lysine acetyltransferase 8	Homo sapiens	9-12
27156644-3	2016	The immobilization was carried out through covalent immobilization of the AR through the terminal amino group or through available carboxylic acids.	Carboxylic Acids	131-147	androgen receptor	Homo sapiens	74-76
27134014-3	2016	After hydrolysis, the mixed SAMs exhibit behaviors from antimicrobial to antifouling, since the COOCH3-thiols were translated into carboxylic acid (COO(-)-) terminated thiols, which carried a net charge of -1 e. Simulation results showed that the main differences between COOCH3-/N(CH3)3(+)-SAM and COO(-)-/N(CH3)3(+)-SAM are the charged property and the hydration layer above the surface.	Carboxylic Acids	131-146	methionine adenosyltransferase 1A	Homo sapiens	28-32
27309907-3	2016	In this article, the discovery of selective, direct acting S1P1 agonists utilizing an ethanolamine scaffold containing a terminal carboxylic acid is described.	Carboxylic Acids	130-145	sphingosine-1-phosphate receptor 1	Rattus norvegicus	59-63
27384481-2	2016	Based on the basic mechanism of ALDH converting aldehyde to carboxylic acid with by-product NADH, we suggested that ALDH1L1 may contribute to ATP production using NADH through oxidative phosphorylation.	Carboxylic Acids	60-75	aldehyde dehydrogenase 1 family member L1	Homo sapiens	116-123
27448759-3	2016	Our previous studies showed that statins containing carboxylic acid chains possessed activity against histone deacetylases (HDACs), and strengthened their anti-HDAC activity through designing HMGR-HDAC dual inhibitors, JMF compounds.	Carboxylic Acids	52-67	high mobility group AT-hook 1	Homo sapiens	192-196
27006111-2	2016	A novel IELC method for the separation of this class of carboxylic acids by either HPLC or UHPLC utilizing a C18 column dynamically modified with sodium dodecyl sulfate has been developed.	Carboxylic Acids	56-72	Bardet-Biedl syndrome 9	Homo sapiens	109-112
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Carboxylic Acids	182-197	aldehyde dehydrogenase 3 family member A2	Homo sapiens	39-67
27107124-2	2016	This enzyme converted not only small aldehydes to carboxylic acids but also the large aldehyde all-trans-retinal to all-trans-retinoic acid with NAD(P)(+) We newly found that BcALDH and human ALDH (ALDH1A1) could reduce all-trans-retinal to all-trans-retinol with NADPH.	Carboxylic Acids	50-66	aldehyde dehydrogenase 1 family member A1	Homo sapiens	177-181
27107124-2	2016	This enzyme converted not only small aldehydes to carboxylic acids but also the large aldehyde all-trans-retinal to all-trans-retinoic acid with NAD(P)(+) We newly found that BcALDH and human ALDH (ALDH1A1) could reduce all-trans-retinal to all-trans-retinol with NADPH.	Carboxylic Acids	50-66	aldehyde dehydrogenase 1 family member A1	Homo sapiens	198-205
26820360-2	2016	The immunosensor was constructed by immobilizing a monoclonal anti-CA 15-3 antibody on the GO modified cysteamine (Cys) self-assembled monolayer (SAM) on an Au electrode (Au/Cys) through the amide bond formation between the carboxylic acid groups of GO/Py-COOH and amine groups of anti-CA 15-3.	Carboxylic Acids	224-239	mucin 1, cell surface associated	Homo sapiens	67-74
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Carboxylic Acids	182-197	aldehyde dehydrogenase 3 family member A2	Homo sapiens	69-74
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Carboxylic Acids	182-197	aldo-keto reductase family 1 member B	Homo sapiens	77-93
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Carboxylic Acids	182-197	aldo-keto reductase family 1 member B	Homo sapiens	95-97
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Carboxylic Acids	182-197	glutathione S-transferase kappa 1	Homo sapiens	295-320
27012748-15	2016	The major neutralizing enzymes include fatty aldehyde dehydrogenase (FALDH), aldose reductase (AR) and alcohol dehydrogenase (ADH), which transform the aldehyde to the corresponding carboxylic acid or alcohols, respectively, or by biding to the thiol group in glutathione (GSH) by the action of glutathione-S-transferase (GST).	Carboxylic Acids	182-197	glutathione S-transferase kappa 1	Homo sapiens	322-325
27100118-1	2016	This note describes a dimethyl dicarbonate-assisted, Pd(OAc)2/PPh3-catalyzed acylative Suzuki coupling of carboxylic acids with diarylborinic acids or tetraarylboronates for practical and efficient synthesis of sterically undemanding aryl ketones at room temperature.	Carboxylic Acids	106-122	caveolin 1	Homo sapiens	62-66
27052724-2	2016	Examples include glucose oxidation with glucose dehydrogenase to regulate blood glucose level, alcohol dissolution into carboxylic acid through alcohol dehydrogenase, and voltage-regulated H(+) channels activating bioluminescence in firefly and jellyfish.	Carboxylic Acids	120-135	aldo-keto reductase family 1 member A1	Homo sapiens	144-165
27120343-3	2016	The zinc benzonaphthoporphyrazine sensitizer NcS1 possessing one carboxylic acid and six 2,6-diisopropylphenoxy units showed a PCE value of 3.2% when used as a light-harvesting dye on a TiO2 electrode under one sun condition.	Carboxylic Acids	65-80	neuronal calcium sensor 1	Homo sapiens	45-49
27143882-3	2016	MATERIALS AND METHODS: The carboxylic acid groups were functionalized on the sidewalls of single-walled CNTs (SWCNTs) followed by diimidation to form amide bonds with the amine groups of the insulin.	Carboxylic Acids	27-42	insulin	Homo sapiens	191-198
26844930-5	2016	The most potent inhibitor 2-(benzyloxy)-6-(4-chloro-3,5-dimethylphenoxy)nicotinic acid (1 r: Ki =2.90 mum) likely binds in the p2 pocket of Mcl-1 and engages R263 in a salt bridge through its carboxylic acid, as supported by 2D (1) H-(15) N HSQC NMR data.	Carboxylic Acids	192-207	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	140-145
26886308-4	2016	Scanning electron microscopy micrographs uncovered its morphology, whereas the spectral data suggested an interaction between the carboxylic acid of DIC and the alkyldimethylamino moiety of RAN.	Carboxylic Acids	130-145	RAN, member RAS oncogene family	Homo sapiens	190-193
26704937-2	2016	Neutralization of the carboxylic acid moiety of the NSAID indomethacin to an ester or amide functionality confers COX-2 selectivity, but the molecular basis for this selectivity has not been completely revealed through mutagenesis studies and/or X-ray crystallographic attempts.	Carboxylic Acids	22-37	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	114-119
26577527-4	2016	Aldehyde dehydrogenase (ALDH) superfamily contains NAD(P)(+)-dependent isozymes which can detoxify endogenous and exogenous aldehydes into non-toxic carboxylic acids.	Carboxylic Acids	149-165	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	0-22
26577527-4	2016	Aldehyde dehydrogenase (ALDH) superfamily contains NAD(P)(+)-dependent isozymes which can detoxify endogenous and exogenous aldehydes into non-toxic carboxylic acids.	Carboxylic Acids	149-165	aldehyde dehydrogenase 3 family, member A1	Rattus norvegicus	24-28
26678554-2	2016	Novel glyoxalase activity, converting alpha-oxoaldehydes to carboxylic acids, has been reported for DJ-1 homologs in humans, worms, plants and bacteria.	Carboxylic Acids	60-76	Parkinsonism associated deglycase	Homo sapiens	100-104
26653735-4	2016	We previously have described highly potent and selective carboxylic acid containing MMP-13 inhibitors; however, nephrotoxicity in preclinical toxicology species precluded development.	Carboxylic Acids	57-72	matrix metallopeptidase 13	Homo sapiens	84-90
26653735-6	2016	Herein we report our efforts to optimize the MMP-13 potency and pharmacokinetic properties of non-carboxylic acid leads resulting in the identification of compound 43a lacking the previously observed preclinical toxicology at comparable exposures.	Carboxylic Acids	98-113	matrix metallopeptidase 13	Homo sapiens	45-51
27477658-5	2016	Through continuous study of the structure-CaSR-activity relation of a large number of gamma-glutamyl peptides, we have determined that the structural requirements for intense CaSR activity of gamma-glutamyl peptides are as follows: existence of an N-terminal gamma-L-glutamyl residue; existence of a moderately sized, aliphatic, neutral substituent at the second residue in an L-configuration; and existence of a C-terminal carboxylic acid, preferably with the existence of glycine as the third constituent.	Carboxylic Acids	424-439	calcium sensing receptor	Homo sapiens	175-179
26678172-3	2016	The carboxylic acids were generally poor inhibitors of isoforms hCA I, II and IV but were highly effective, low nanomolar inhibitors of hCA VII and XII.	Carboxylic Acids	4-20	carbonic anhydrase 1	Homo sapiens	64-69
26678172-3	2016	The carboxylic acids were generally poor inhibitors of isoforms hCA I, II and IV but were highly effective, low nanomolar inhibitors of hCA VII and XII.	Carboxylic Acids	4-20	carbonic anhydrase 7	Homo sapiens	136-151
27162011-3	2016	The biological evaluation of the obtained compounds showed that the carboxylic acid functionality of the lead compounds is of special importance for a pronounced inhibition of cPLA2alpha and FAAH.	Carboxylic Acids	68-83	phospholipase A2 group IVA	Homo sapiens	176-186
27162011-3	2016	The biological evaluation of the obtained compounds showed that the carboxylic acid functionality of the lead compounds is of special importance for a pronounced inhibition of cPLA2alpha and FAAH.	Carboxylic Acids	68-83	fatty acid amide hydrolase	Homo sapiens	191-195
26554162-2	2015	Primary antibody-AFP (Ab1) was immobilized onto the surface of reduced graphene nanosheets (rGO) through an amidation reaction between the carboxylic acid group of the rGO and the available amine groups of Ab1.	Carboxylic Acids	139-154	alpha fetoprotein	Homo sapiens	17-20
27424891-2	2016	The identification of several natural phenols and thieno[3,2-b]thiophene-2-carboxylic acid derivatives as agonists for GPR35, an orphan G protein-coupled receptor, had motivated us to examine the pharmacological activity of D-Luciferin, given that it also contains phenol and carboxylic acid moieties.	Carboxylic Acids	75-90	G protein-coupled receptor 35	Homo sapiens	119-124
26471326-4	2016	The first step is likely to be conversion of carbon-15 (C15) from a methyl group to a carboxylic acid by a cytochrome P450 mono-oxygenase (CYP).	Carboxylic Acids	86-101	cytochrome P450 711A1-like	Zea mays	107-137
26471326-4	2016	The first step is likely to be conversion of carbon-15 (C15) from a methyl group to a carboxylic acid by a cytochrome P450 mono-oxygenase (CYP).	Carboxylic Acids	86-101	cytochrome P450 711A1-like	Zea mays	139-142
26694455-4	2015	Montelukast is a carboxylic acid, a relatively potent inhibitor of OATP1B1, OATP1B3, and OATP2B1, and has previously been postulated to be actively transported into human hepatocytes.	Carboxylic Acids	17-32	solute carrier organic anion transporter family member 1B1	Homo sapiens	67-74
26694455-4	2015	Montelukast is a carboxylic acid, a relatively potent inhibitor of OATP1B1, OATP1B3, and OATP2B1, and has previously been postulated to be actively transported into human hepatocytes.	Carboxylic Acids	17-32	solute carrier organic anion transporter family member 1B3	Homo sapiens	76-83
26623975-3	2015	The protocol entails solution-phase synthesis of the Boc-protected pyrrole (Py) and imidazole (Im) carboxylic acid building blocks.	Carboxylic Acids	99-114	BOC cell adhesion associated, oncogene regulated	Homo sapiens	53-56
26428356-10	2015	In the carboxylic acids series the interaction of the carboxylate group with polar residues lining the CYP2E1 active site also has to be considered.	Carboxylic Acids	7-23	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	103-109
25910579-5	2015	Carboxylic acid moiety was additionally substituted to the back bone for ionic interaction with BMP-2.	Carboxylic Acids	0-15	bone morphogenetic protein 2	Mus musculus	96-101
26384288-6	2015	The subsequent introduction of a carboxylic acid moiety into 9 resulted in 14, which showed potent antagonist activity towards S1P2 with a much smaller species difference between human S1P2 and rat S1P2.	Carboxylic Acids	33-48	sphingosine-1-phosphate receptor 2	Homo sapiens	127-131
26306676-10	2015	Our result demonstrates that SAMs carrying carboxylic acid or amine allow for both cell adhesion and cell spreading because of preferentially adsorbed Vn.	Carboxylic Acids	43-58	vitronectin	Homo sapiens	151-153
26601426-0	2015	Cysteine amide adduct formation from carboxylic acid drugs via UGT-mediated bioactivation in human liver microsomes.	Carboxylic Acids	37-52	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	63-66
26601426-2	2015	In this study, we used cysteine (Cys) as trapping agent to gain new insights into the UGT-mediated bioactivation involving acyl glucuronides of carboxylic acid drugs.	Carboxylic Acids	144-159	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	86-89
25943251-6	2015	Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry.	Carboxylic Acids	252-267	interferon gamma	Homo sapiens	13-29
26007302-2	2015	The proposed chemical transformation of the carboxylic acid into an amide group led to a complete loss of hCA I and II inhibition (Kis >10,000nM) and enhanced the inhibitory activity against hCA IX and XII, with respect to the parent compound (incorporating a COOH function).	Carboxylic Acids	44-59	cytochrome P450 family 24 subfamily A member 1	Homo sapiens	106-118
26007302-2	2015	The proposed chemical transformation of the carboxylic acid into an amide group led to a complete loss of hCA I and II inhibition (Kis >10,000nM) and enhanced the inhibitory activity against hCA IX and XII, with respect to the parent compound (incorporating a COOH function).	Carboxylic Acids	44-59	carbonic anhydrase 9	Homo sapiens	194-200
26067160-2	2015	Monodispersed Ag2S nanoparticles with a surface of carboxylic acid-terminated were synthesized in the droplet microreactor.	Carboxylic Acids	51-66	angiotensin II receptor type 1	Homo sapiens	14-18
25936263-7	2015	All derivatives containing carboxylic acid at the position-17(2) were noted to be substrate for the ABCG2 (a member of the ATP binding cassette transporters) protein explaining their low retention in lung tumor cells expressing this transporter.	Carboxylic Acids	27-42	ATP binding cassette subfamily G member 2 (Junior blood group)	Mus musculus	100-105
25943251-6	2015	Biomolecules interferon-gamma (IFNgamma) and platelet-derived growth factor (PDGF) that selectively promote neuronal or oligodendrocyte lineage differentiation, respectively, are covalently cross-linked to the surface of the GO/PEDOT nanocomposite via carboxylic acid functional groups provided by GO using carbodiimide chemistry.	Carboxylic Acids	252-267	interferon gamma	Homo sapiens	31-39
25704243-1	2015	Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite.	Carboxylic Acids	76-91	carboxylesterase 1	Homo sapiens	0-18
26030520-3	2015	Optimized conditions for generating tertiary radicals from N-(acyloxy)phthalimide derivatives of tertiary carboxylic acids by visible-light irradiation in the presence of 1 mol % of commercially available Ru(bpy)3(PF6)2, diethyl 1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylate (8), and i-Pr2NEt and their coupling in dichloromethane at room temperature with alkene acceptors were developed.	Carboxylic Acids	106-122	sperm associated antigen 17	Homo sapiens	214-217
26257441-2	2015	This process was informed by studies of the intramycobacterial metabolism of CD117 and its inactive carboxylic acid derivative.	Carboxylic Acids	100-115	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	77-82
25599616-4	2015	We identified a 4-(phenyl)thio-1H-pyrazole as a novel scaffold for GPR109A agonist in a high throughput screen, which has no carboxylic acid moiety known to be important for binding.	Carboxylic Acids	125-140	hydroxycarboxylic acid receptor 2	Homo sapiens	67-74
25139477-7	2015	With regard to environmental recirculation, tap water was an important source of PFAAs to the Bromma WWTP influent, contributing >40% for each quantified sulfonic acid and up to 30% for the carboxylic acids.	Carboxylic Acids	193-209	nuclear RNA export factor 1	Homo sapiens	44-47
25704243-1	2015	Carboxylesterase 1 (CES1) hydrolyzes the prodrug clopidogrel to an inactive carboxylic acid metabolite.	Carboxylic Acids	76-91	carboxylesterase 1	Homo sapiens	20-24
25945809-9	2015	Competitive inhibition studies of 14 TH-like compounds revealed that recognition by Lat2 requires amino and carboxylic acid groups.	Carboxylic Acids	108-123	solute carrier family 7 member 8 L homeolog	Xenopus laevis	84-88
25790062-6	2015	The MTS reaction using a constitutional isomer of for-HBH that transposed the methylene unit to the carboxylic acid containing region, 5-[(5-aminopentyl)(hydroxy)amino]-5-oxopentanoic acid (for-PPH), gave the macrocycle for-[Fe(HPDFOE)] in a yield significantly less than that for for-[Fe(HHDFOE)], with the gallium(III) analogue for-[Ga(HPDFOE)] unable to be detected.	Carboxylic Acids	100-115	hemoglobin subunit alpha 1	Homo sapiens	54-57
25636004-5	2015	Crystal structures of two such compounds, phenylpyruvate (PPy) and 2-hydroxyimino-3-phenylpropanoic acid (HIPP), show binding with favorable ring stacking against the CtBP active site tryptophan and alternate modes of stabilizing the carboxylic acid moiety.	Carboxylic Acids	234-249	poly(rC) binding protein 2	Mus musculus	167-171
25678153-7	2015	Dye SM1, with two hexyloxyphenyl donors and one carboxylic acid anchor showed the best overall conversion efficiency of 4.36% (JSC = 10.91 mA cm(-2); VOC = 0.59 V; FF = 0.68).	Carboxylic Acids	48-63	SM1	Homo sapiens	4-7
25233258-0	2014	Design, synthesis, 3D pharmacophore, QSAR, and docking studies of carboxylic acid derivatives as Histone Deacetylase inhibitors and cytotoxic agents.	Carboxylic Acids	66-81	histone deacetylase 9	Homo sapiens	97-116
25616005-6	2015	Here we report a novel inactivation mechanism for CPP-115, a mechanism-based inactivator that undergoes GABA-AT-catalyzed hydrolysis of the difluoromethylene group to a carboxylic acid with concomitant loss of two fluoride ions and coenzyme conversion to pyridoxamine 5"-phosphate (PMP).	Carboxylic Acids	169-184	4-aminobutyrate aminotransferase	Homo sapiens	104-111
25474271-1	2015	The LFA-1 inhibitor and leukocyte adhesion suppressor BIRT-377 was prepared in high enantiomeric excess by desymmetrization of dimethyl 2-p-bromobenzyl-2-methylmalonate, followed by condensation of the resulting carboxylic acid with 3,5-dichloroaniline, saponification of the remaining ester and Curtius rearrangement as the key steps.	Carboxylic Acids	212-227	integrin subunit alpha L	Homo sapiens	4-9
25631325-1	2015	A rhodium(III)-catalyzed carboxylic acid directed decarboxylative C-H/C-H cross-coupling of carboxylic acids with thiophenes has been developed.	Carboxylic Acids	25-40	churchill domain containing 1	Homo sapiens	66-73
25631325-1	2015	A rhodium(III)-catalyzed carboxylic acid directed decarboxylative C-H/C-H cross-coupling of carboxylic acids with thiophenes has been developed.	Carboxylic Acids	92-108	churchill domain containing 1	Homo sapiens	66-73
25697780-1	2015	Pd-catalyzed beta-C-H functionalizations of carboxylic acid derivatives using an auxiliary as a directing group have been extensively explored in the past decade.	Carboxylic Acids	44-59	colony stimulating factor 2 receptor subunit beta	Homo sapiens	13-19
25680633-2	2015	To improve cell attachment, arginine-glycine-aspartic acid-serine (RGDS) peptides were covalently grafted to chitosan films, through the widely used coupling agents 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC-HCl) and N-hydroxysuccinimide (NHS), via the carboxylic acid function of the RGDS molecule.	Carboxylic Acids	261-276	ral guanine nucleotide dissociation stimulator	Homo sapiens	67-71
25634381-1	2015	Aldehyde dehydrogenases (ALDH) catalyze the irreversible oxidation of aldehydes to their corresponding carboxylic acid.	Carboxylic Acids	103-118	aldehyde dehydrogenase 1 family member A1	Homo sapiens	25-29
25760528-4	2015	UDP-glucuronosyltransferase (UGT) is a non-P450 enzyme that catalyzes glucuronidation, a major pathway for drugs possessing carboxylic acid, hydroxyl, and amine moieties.	Carboxylic Acids	124-139	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	0-27
25760528-4	2015	UDP-glucuronosyltransferase (UGT) is a non-P450 enzyme that catalyzes glucuronidation, a major pathway for drugs possessing carboxylic acid, hydroxyl, and amine moieties.	Carboxylic Acids	124-139	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	29-32
25425668-6	2014	MAX1 catalyzed consecutive oxidations at C-19 of CL to convert the C-19 methyl group into carboxylic acid, 9-desmethyl-9-carboxy-CL [designated as carlactonoic acid (CLA)].	Carboxylic Acids	90-105	cytochrome P450, family 711, subfamily A, polypeptide 1	Arabidopsis thaliana	0-4
25421939-9	2014	The x-ray crystal structures of BI-D binding to WT and H171T IN CCD dimers coupled with binding free energy calculations revealed the importance of the Ndelta- protonated imidazole group of His171 for hydrogen bonding to the BI-D tert-butoxy ether oxygen and establishing electrostatic interactions with the inhibitor carboxylic acid, whereas these interactions were compromised upon substitution to Thr171.	Carboxylic Acids	318-333	BH3 interacting domain death agonist	Homo sapiens	32-36
25277139-8	2014	The experimental and theoretical data were in agreement, which showed that substitution of the AA carboxylic acid with the 2-AG ester-glycerol changes the binding interaction of these lipids within the CYP2J2 active site, leading to different product distributions.	Carboxylic Acids	98-113	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	202-208
25441157-1	2014	In this paper, we have synthesized hyperbranched polyester microspheres with carboxylic acid functional groups (HBPE-CA) and developed a label-free electrochemical aptamer biosensor using thrombin-binding aptamer (TBA) as receptor for the measurement of thrombin in whole blood.	Carboxylic Acids	77-92	coagulation factor II, thrombin	Homo sapiens	188-196
25421939-9	2014	The x-ray crystal structures of BI-D binding to WT and H171T IN CCD dimers coupled with binding free energy calculations revealed the importance of the Ndelta- protonated imidazole group of His171 for hydrogen bonding to the BI-D tert-butoxy ether oxygen and establishing electrostatic interactions with the inhibitor carboxylic acid, whereas these interactions were compromised upon substitution to Thr171.	Carboxylic Acids	318-333	BH3 interacting domain death agonist	Homo sapiens	225-229
25363411-2	2014	Taking a series of carboxylic acid-based MMP-13 inhibitors as research object, this work utilized an extended QSAR method to analyze the structure-activity relationships.	Carboxylic Acids	19-34	matrix metallopeptidase 13	Homo sapiens	41-47
25264600-3	2014	Among them, carboxylic acid inhibitor 21k exhibited excellent potency and selectivity for MMP-13 over other MMPs.	Carboxylic Acids	12-27	matrix metallopeptidase 13	Rattus norvegicus	90-96
25264600-3	2014	Among them, carboxylic acid inhibitor 21k exhibited excellent potency and selectivity for MMP-13 over other MMPs.	Carboxylic Acids	12-27	matrix metallopeptidase 13	Rattus norvegicus	108-112
25454657-5	2014	Implemented carboxylic acid groups were converted into amine-reactive esters and covalently coupled to VEGF by forming stable amide bonds (standard EDC/NHS chemistry).	Carboxylic Acids	12-27	vascular endothelial growth factor A	Homo sapiens	103-107
25172614-4	2014	The results, mainly, showed the sorption of PFASs onto pellet surface from surrounding water with concentrations from method limit of quantification to 115 ng/kg for C5, C7, C8 and C10 carboxylic acids and C8 sulfonate acid.	Carboxylic Acids	185-201	homeobox C10	Homo sapiens	181-184
25152419-2	2014	The amino, thiol and carboxylic acid functional groups available on protein coated surface were utilized for covalent immobilization of glucose oxidase and beta-galactosidase, both independently, and in a step-wise manner on the same matrix, with no more than 10% loss of enzyme activity during immobilization.	Carboxylic Acids	21-36	galactosidase beta 1	Homo sapiens	156-174
25210805-1	2014	We have previously described Pb(II) and Bi(III) bimetallic complexes with overhanging carboxylic acid strapped porphyrins in which one metal ion is bound to the N-core ("out-of-plane", OOP), whereas the second one is bound to the strap ("hanging-atop", HAT).	Carboxylic Acids	86-101	submaxillary gland androgen regulated protein 3B	Homo sapiens	29-35
25210805-1	2014	We have previously described Pb(II) and Bi(III) bimetallic complexes with overhanging carboxylic acid strapped porphyrins in which one metal ion is bound to the N-core ("out-of-plane", OOP), whereas the second one is bound to the strap ("hanging-atop", HAT).	Carboxylic Acids	86-101	serine/threonine kinase receptor associated protein	Homo sapiens	102-107
24996175-7	2014	AOX1 is an enzyme of pharmacological and toxicological importance that metabolizes numerous xenobiotics to their respective carboxylic acids.	Carboxylic Acids	124-140	aldehyde oxidase 1	Mus musculus	0-4
24988361-4	2014	We found that (i) DAGL-alpha tolerates a variety of biaryl substituents, (ii) the sulfonamide is required for inducing a specific orientation of the 2,2-dimethylchroman substituent, and (iii) a carboxylic acid is essential for its activity.	Carboxylic Acids	194-209	diacylglycerol lipase alpha	Homo sapiens	18-28
25115848-2	2014	The synthesis and application of bright, highly water-soluble, and negatively charged sulfonic- or carboxylic acid derivatives of para-substituted aryl-alkynyl triazacyclononane complexes are described.	Carboxylic Acids	99-114	AT-rich interaction domain 3A	Homo sapiens	33-39
25046557-7	2014	It is shown that polymers with multiple phosphonic acid functionalities and PEG chains outperform other types of coating, including ligands, polyelectrolytes, and carboxylic acid functionalized PEG.	Carboxylic Acids	163-178	progestagen associated endometrial protein	Homo sapiens	194-197
24575896-0	2014	Contribution of cytochrome P450 and UDT-glucuronosyltransferase to the metabolism of drugs containing carboxylic acid groups: risk assessment of acylglucuronides using human hepatocytes.	Carboxylic Acids	102-117	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	16-31
24628410-14	2014	The carboxylic acid nature of both drugs may contribute to the prolonged COX-2 inhibition in exudate, despite short half-lives in blood.	Carboxylic Acids	4-19	cytochrome c oxidase subunit II	Felis catus	73-78
24560625-3	2014	Substrate dependency and high selectivity in binding of naphthoquinone tethered carboxylic acids or pyridines with bovine serum albumin (BSA) and human serum albumin (HSA) are observed.	Carboxylic Acids	80-96	albumin	Homo sapiens	122-141
25010490-7	2014	This seems to be a trend for carboxylic acids on complexing BeX2 compounds.	Carboxylic Acids	29-45	brain expressed X-linked 2	Homo sapiens	60-64
24728488-8	2014	In particular, UGT1A1, UGT1A7, and UGT1B1 displayed good glucuronidation activities toward most phenolic aglycones (4-methylumbelliferone, 4-nitrophenol, 1-naphthol, bisphenol A, and mycophenolic acid) and the two carboxylic acids (bilirubin and diclofenac).	Carboxylic Acids	214-230	UDP-glucuronosyltransferase 1-1	Danio rerio	15-21
24728488-8	2014	In particular, UGT1A1, UGT1A7, and UGT1B1 displayed good glucuronidation activities toward most phenolic aglycones (4-methylumbelliferone, 4-nitrophenol, 1-naphthol, bisphenol A, and mycophenolic acid) and the two carboxylic acids (bilirubin and diclofenac).	Carboxylic Acids	214-230	UDP glucuronosyltransferase 1 family, polypeptide A7	Danio rerio	23-29
24728488-8	2014	In particular, UGT1A1, UGT1A7, and UGT1B1 displayed good glucuronidation activities toward most phenolic aglycones (4-methylumbelliferone, 4-nitrophenol, 1-naphthol, bisphenol A, and mycophenolic acid) and the two carboxylic acids (bilirubin and diclofenac).	Carboxylic Acids	214-230	UDP glucuronosyltransferase 1 family, polypeptide B1	Danio rerio	35-41
24994116-3	2014	EMT-induced CS-like cells (HMLERshEcad) and isogenic parental cells (HMLERshCntrol) were simultaneously screened for their ability to generate energy-rich NADH when cultured in a standardized high-throughput metabolic phenotyping platform comprising >350 wells that were pre-loaded with different carbohydrates/starches, alcohols, fatty acids, ketones, carboxylic acids, amino acids, and bi-amino acids.	Carboxylic Acids	356-372	IL2 inducible T cell kinase	Homo sapiens	0-3
24628008-3	2014	Enzyme immobilization was successfully accomplished using 3-(3-dimethylaminopropyl) carbodiimide/N-hydroxysuccinimide (EDC/NHS) coupling to carboxylic acid functionalized PMMA micropillars.	Carboxylic Acids	140-155	NHS actin remodeling regulator	Homo sapiens	123-126
24752820-1	2014	Unactivated carboxylic acids and amines undergo organocatalytic Ph3P/CCl4-mediated amide bond formation by employing in situ reduction of triphenylphosphine oxide to triphenylphosphine in the presence of diethoxymethylsilane and bis(4-nitrophenyl)phosphate.	Carboxylic Acids	12-28	C-C motif chemokine ligand 4	Homo sapiens	69-73
24560625-3	2014	Substrate dependency and high selectivity in binding of naphthoquinone tethered carboxylic acids or pyridines with bovine serum albumin (BSA) and human serum albumin (HSA) are observed.	Carboxylic Acids	80-96	albumin	Homo sapiens	122-135
24512105-10	2014	The enzyme encoded by CES1 is a major liver enzyme that typically catalyzes the decomposition of ester into alcohol and carboxylic acid and is involved in drug or xenobiotics, fatty acid, and cholesterol metabolisms.	Carboxylic Acids	120-135	carboxylesterase 1	Homo sapiens	22-26
25050159-4	2014	We investigated a structural series containing carboxylic acids to reduce the putative hERG off-target activity.	Carboxylic Acids	47-63	ETS transcription factor ERG	Homo sapiens	87-91
24576660-1	2014	Glycine N-acyltransferase (GLYAT) is a phase II metabolic detoxification enzyme for exogenous (xenobiotic) and endogenous carboxylic acids; consisting of fatty acids, benzoic acid, and salicylic acid.	Carboxylic Acids	122-138	glycine-N-acyltransferase	Mus musculus	0-25
24576660-1	2014	Glycine N-acyltransferase (GLYAT) is a phase II metabolic detoxification enzyme for exogenous (xenobiotic) and endogenous carboxylic acids; consisting of fatty acids, benzoic acid, and salicylic acid.	Carboxylic Acids	122-138	glycine-N-acyltransferase	Mus musculus	27-32
24576660-8	2014	The successful recombinant expression and purification of mGLYAT can lead to solve unanswered questions associated with this enzyme, consisting of what is the chemical mechanism and what catalytic residues are essential for the how this phase II metabolic detoxification enzyme conjugates glycine to xenobiotic and endogenous carboxylic acids.	Carboxylic Acids	326-342	glycine-N-acyltransferase	Mus musculus	58-64
24434942-5	2014	The decomposition products of the oxidized PC2 contained CO2, acetone, propanal, propene, and carboxylic acid in agreement with the previous experimental studies.	Carboxylic Acids	94-109	keratin 6B	Homo sapiens	43-46
24732569-6	2014	We focused on the unique structure of a triazolopyrimidine scaffold that lacks a carboxylic acid to design the TAP1 probe that can undergo facilitated delivery across cell membranes.	Carboxylic Acids	81-96	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	111-115
24673361-1	2014	A discrete nanocage of core-shell design, in which carboxylic acid groups were tethered to the core and silanol to the shell interior, was found to react with Co2(CO)8 to form and stabilize a Co(I)-CO species.	Carboxylic Acids	51-66	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	192-197
24601644-2	2014	These inhibitors have in common a carboxylic acid moiety that engages in an electrostatic interaction with MDM2-His96.	Carboxylic Acids	34-49	MDM2 proto-oncogene	Homo sapiens	107-111
24548175-4	2014	We sought to investigate whether the versatile reactivity of the thioacids can be tuned for the conversion of carboxylic acids into corresponding thioacids in the presence of NaSH.	Carboxylic Acids	110-126	SAM domain, SH3 domain and nuclear localization signals 1	Homo sapiens	175-179
24618302-1	2014	Herein we report the design and synthesis of a series of novel bicyclic DGAT1 inhibitors with a carboxylic acid moiety.	Carboxylic Acids	96-111	diacylglycerol O-acyltransferase 1	Homo sapiens	72-77
24317299-1	2014	Amphoteric beta-1,3-glucans possessing both amino groups and carboxylic acid groups on the C6 positions of glucose units were designed and synthesized from naturally produced curdlan.	Carboxylic Acids	61-76	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	11-19
24530494-5	2014	Carboxylic acid derivatives 5 and 11 showed a multipotent moderate selective profile as EeACE and MAO A inhibitors.	Carboxylic Acids	0-15	monoamine oxidase A	Homo sapiens	98-103
24405416-4	2014	Herein we report the design, synthesis and optimization of YH239-EE (ethyl ester of the free carboxylic acid compound YH239), a potent p53-MDM2 antagonizing and apoptosis-inducing agent characterized by a number of leukemia cell lines as well as patient-derived AML blast samples.	Carboxylic Acids	93-108	tumor protein p53	Homo sapiens	135-138
24491842-3	2014	As a result of the comparison among the eight sugar-containing reductants, it was determined that C-6 of glycosides is oxidized to a carboxylic acid during the reduction of auric acid.	Carboxylic Acids	133-148	complement C6	Homo sapiens	98-101
24452510-4	2014	Our findings indicate that almost 40 % of entries deposited to the Protein Data Bank (PDB) reporting crystallization conditions contain at least one carboxylic acid.	Carboxylic Acids	149-164	dehydrogenase/reductase 2	Homo sapiens	67-84
24339217-2	2014	The derivatives show pronounced aggregation due to the synergistic effects of H-bonding between the carboxylic acid groups in a syn-syn catemer motif and pi stacking between the NDI chromophores.	Carboxylic Acids	100-115	synemin	Homo sapiens	55-58
24299827-4	2014	Here, GC-g-DMA-g-C60 nanogels also formed multi-nanogel aggregates due to the electrostatic interaction between the pendant carboxylic acid group (due to the DMA) and residual free amine group of GC at pH 7.4.	Carboxylic Acids	124-139	glucagon	Homo sapiens	6-10
24636064-0	2014	Inhibitory effect of medicinal plant-derived carboxylic acids on the human transporters hOAT1, hOAT3, hOATP1B1, and hOATP2B1.	Carboxylic Acids	45-61	solute carrier family 22 member 6	Homo sapiens	88-93
24636064-0	2014	Inhibitory effect of medicinal plant-derived carboxylic acids on the human transporters hOAT1, hOAT3, hOATP1B1, and hOATP2B1.	Carboxylic Acids	45-61	solute carrier family 22 member 8	Homo sapiens	95-100
24636064-0	2014	Inhibitory effect of medicinal plant-derived carboxylic acids on the human transporters hOAT1, hOAT3, hOATP1B1, and hOATP2B1.	Carboxylic Acids	45-61	solute carrier organic anion transporter family member 1B1	Homo sapiens	102-110
24636064-0	2014	Inhibitory effect of medicinal plant-derived carboxylic acids on the human transporters hOAT1, hOAT3, hOATP1B1, and hOATP2B1.	Carboxylic Acids	45-61	solute carrier organic anion transporter family member 2B1	Homo sapiens	116-124
24339217-2	2014	The derivatives show pronounced aggregation due to the synergistic effects of H-bonding between the carboxylic acid groups in a syn-syn catemer motif and pi stacking between the NDI chromophores.	Carboxylic Acids	100-115	synemin	Homo sapiens	128-131
24148241-9	2014	Conversely, at pH 2, E generally increases with addition of the nonionic MAA copolymer due to strong preferential adsorption to the uncharged carboxylic-acid group of MAA.	Carboxylic Acids	142-157	MAA	Homo sapiens	73-76
24148241-9	2014	Conversely, at pH 2, E generally increases with addition of the nonionic MAA copolymer due to strong preferential adsorption to the uncharged carboxylic-acid group of MAA.	Carboxylic Acids	142-157	MAA	Homo sapiens	167-170
23994369-7	2013	DHNB interacted with the molybdenum center of XO and was slowly converted to its carboxylic acid at a rate of 10-10 mol/L/s.	Carboxylic Acids	81-96	xanthine dehydrogenase	Mus musculus	46-48
24328274-3	2013	Such extraordinary stability hampers the individual binding of either carboxylic acid ligands through the amidine group or pyridine-type ligands through the Zn(II) metal atom to (Pc1)2.	Carboxylic Acids	70-85	polycystin 1, transient receptor potential channel interacting	Homo sapiens	179-182
24245989-2	2013	Its utility as an asymmetric variant of [CpRu(MeCN)3]PF6 is demonstrated through its ability to function in the branched-selective asymmetric allylic alkylation of phenols and carboxylic acids.	Carboxylic Acids	176-192	sperm associated antigen 17	Homo sapiens	53-56
24094436-2	2013	Modification of the carboxylic acid moiety of 2 gave N-neopentylacetamide derivative 10f, which had high in vitro PDE4B inhibitory activity (IC50=8.3 nM) and in vivo efficacy against lipopolysaccharide (LPS)-induced pulmonary neutrophilia in mice (ID50=16 mg/kg, ip).	Carboxylic Acids	20-35	phosphodiesterase 4B, cAMP specific	Mus musculus	114-119
24908294-6	2014	For this purpose, a 3D biosensor was composed of multi-walled carbon nanotubes with carboxylic acid functionalities (multi-walled carbon nanotubes-COOH) to increase the surface area for the range of human IL-10 detection.	Carboxylic Acids	84-99	interleukin 10	Homo sapiens	205-210
24061865-2	2013	In blood, BEN is rapidly metabolized into its highly reactive carboxylic acid (BA), presumably the predominant alkylating species.	Carboxylic Acids	62-77	general transcription factor II I repeat domain-containing 1	Mus musculus	10-13
23790185-0	2013	The transport of carboxylic acids and important role of the Jen1p transporter during the development of yeast colonies.	Carboxylic Acids	17-33	Jen1p	Saccharomyces cerevisiae S288C	60-65
23987321-0	2013	Preparation of carboxylic acid-bearing polysaccharide nanofiber made from euglenoid beta-1,3-glucans.	Carboxylic Acids	15-30	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	84-92
24059847-3	2013	Retinoic acid (RA), the carboxylic acid form of vitamin A, displays agonist activity toward several nuclear hormone receptors, including RA receptors (RARs) and peroxisome proliferator-activated receptor delta (PPARdelta).	Carboxylic Acids	24-39	arginyl-tRNA synthetase	Mus musculus	137-149
24059847-3	2013	Retinoic acid (RA), the carboxylic acid form of vitamin A, displays agonist activity toward several nuclear hormone receptors, including RA receptors (RARs) and peroxisome proliferator-activated receptor delta (PPARdelta).	Carboxylic Acids	24-39	arginyl-tRNA synthetase	Mus musculus	151-155
24059847-3	2013	Retinoic acid (RA), the carboxylic acid form of vitamin A, displays agonist activity toward several nuclear hormone receptors, including RA receptors (RARs) and peroxisome proliferator-activated receptor delta (PPARdelta).	Carboxylic Acids	24-39	peroxisome proliferator activator receptor delta	Mus musculus	161-209
24059847-3	2013	Retinoic acid (RA), the carboxylic acid form of vitamin A, displays agonist activity toward several nuclear hormone receptors, including RA receptors (RARs) and peroxisome proliferator-activated receptor delta (PPARdelta).	Carboxylic Acids	24-39	peroxisome proliferator activator receptor delta	Mus musculus	211-220
23906380-3	2013	Surface functional group conversion to carboxylic acid was accomplished by conjugating poly(ethylene glycol) diacid to IONP-Sil(NH2).	Carboxylic Acids	39-54	STIL centriolar assembly protein	Homo sapiens	124-127
23871442-3	2013	The carboxylic acid-based DGAT-1 inhibitor 1 was advanced to clinical trials for the treatment of type 2 diabetes, despite of the low passive permeability of 1.	Carboxylic Acids	4-19	diacylglycerol O-acyltransferase 1	Homo sapiens	26-32
23748131-1	2013	A carboxylic acid ligand, (Z)-4-(4-acetylphenylamino)-4-oxobut-2-enoic acid (APA-1), and its triphenyl-(APA-2) and tributyl-tin(IV) (APA-3) compounds have been synthesized and investigated for their binding with ds.DNA using UV-visible spectroscopy, fluorescence spectroscopy, cyclic voltammetry, and viscosity measurements under physiological conditions of pH and temperature.	Carboxylic Acids	2-17	zinc finger protein 410	Homo sapiens	77-82
22743087-4	2013	Our current paper compares the abilities of a variety of amino acid residues and derivatives to serve as pThr/pSer replacements by exploring the role of methyl functionality at the pThr beta-position and by replacing the phosphoryl group by phosphonic acid, sulfonic acid and carboxylic acids.	Carboxylic Acids	276-292	parathyroid hormone 1 receptor	Homo sapiens	105-109
23639650-2	2013	From SAR studies, the presence of alpha-l-rhamnosyl residue at the terminal of both C-3 and C-28 position for oleanolic acid bidesmosides was important to enhance cytotoxicity, and introducing more sugar residues at C3-OH of compound 12 with C-28 carboxylic acid is a favorable modification to ameliorate the anticancer activity.	Carboxylic Acids	247-262	complement C3	Homo sapiens	84-87
23758209-0	2013	Cu-catalyzed mild C(sp2)-H functionalization assisted by carboxylic acids en route to hydroxylated arenes.	Carboxylic Acids	57-73	Sp2 transcription factor	Homo sapiens	18-23
23701017-2	2013	We present porous graphitic carbon particles with covalently attached carboxylic acid groups (carboxylate-PGC) as a new HILIC stationary phase.	Carboxylic Acids	70-85	progastricsin	Homo sapiens	106-109
23701017-7	2013	The chromatographic performance of carboxylate-PGC as a HILIC phase is illustrated by separations of carboxylic acids, nucleotides, phenols, and amino acids.	Carboxylic Acids	101-117	progastricsin	Homo sapiens	47-50
23293887-5	2013	The docking studies of most potent analog (7) with 3D crystal structure of the nuclear factor kappa-B (NF-kappaB) P50 homodimer (PDB ID: 1NFK) revealed that carbonyl group of ester side chain and C-28 carboxylic acid groups were mainly involved in hydrogen bonding interaction.	Carboxylic Acids	201-216	nuclear factor kappa B subunit 1	Homo sapiens	79-101
23293887-5	2013	The docking studies of most potent analog (7) with 3D crystal structure of the nuclear factor kappa-B (NF-kappaB) P50 homodimer (PDB ID: 1NFK) revealed that carbonyl group of ester side chain and C-28 carboxylic acid groups were mainly involved in hydrogen bonding interaction.	Carboxylic Acids	201-216	nuclear factor kappa B subunit 1	Homo sapiens	103-112
23357006-6	2013	Human aldehyde dehydrogenase 2 (ALDH2), which is responsible for the oxidation of aldehydes to carboxylic acids, is then utilized as a target for SNP.	Carboxylic Acids	95-111	aldehyde dehydrogenase 2 family member	Homo sapiens	6-30
23357006-6	2013	Human aldehyde dehydrogenase 2 (ALDH2), which is responsible for the oxidation of aldehydes to carboxylic acids, is then utilized as a target for SNP.	Carboxylic Acids	95-111	aldehyde dehydrogenase 2 family member	Homo sapiens	32-37
23506825-2	2013	Clinical trials of PF-04691502, a highly potent and selective ATP competitive kinase inhibitor of class 1 PI3Ks and mTOR, from 4-methylpyridopyrimidinone series, led to the discovery of a metabolite with a terminal carboxylic acid, PF-06465603.	Carboxylic Acids	215-230	mechanistic target of rapamycin kinase	Homo sapiens	116-120
23581529-1	2013	The competitive adsorption of long-chain (C18 and C24) carboxylic acids versus n-decanol on graphite was investigated using frequency-modulation atomic force microscopy.	Carboxylic Acids	55-71	Bardet-Biedl syndrome 9	Homo sapiens	42-45
23667093-7	2013	MATERIAL/METHODS: In this study, using real-time PCR we measured relative mRNA expression, in the mutants compared to the wild-type strain, of selected genes associated with both carboxylic acid cycles and two cell transporters, Pma1 and Pdr12, of organic acids.	Carboxylic Acids	179-194	H(+)-exporting P2-type ATPase PMA1	Saccharomyces cerevisiae S288C	229-233
23510563-1	2013	Carboxylic acid derivatives of pyridoxal were developed as potent P2X(1) and P2X(3) receptor antagonists with modifications of a lead compound, pyridoxal-5"-phosphate-6-azophenyl-2",5"-disulfonate (5b, iso-PPADS).	Carboxylic Acids	0-15	purinergic receptor P2X 1	Homo sapiens	66-72
23618537-8	2013	Multi-stage tandem mass spectrometry (MSn) experiments of SPE extracts of the ozonated samples of E1 and of a deuterium-labeled analogue (E1-d4) showed that OTP-276 and OTP-318 had carboxylic acid and hydroxyl functional groups, as previously reported for OTPs of other hormones.	Carboxylic Acids	181-196	orthopedia homeobox	Homo sapiens	157-160
23618537-8	2013	Multi-stage tandem mass spectrometry (MSn) experiments of SPE extracts of the ozonated samples of E1 and of a deuterium-labeled analogue (E1-d4) showed that OTP-276 and OTP-318 had carboxylic acid and hydroxyl functional groups, as previously reported for OTPs of other hormones.	Carboxylic Acids	181-196	orthopedia homeobox	Homo sapiens	169-172
22639973-6	2013	KEY RESULTS Calculated hydrogen bonding energies between a series of synthetic carboxylic acid compounds and the homology models of the FFA1 receptor and GPR120, using docking simulations, correlated well with the effects of the compounds on ERK phosphorylation in transfected cells (R(2) = 0.65 for FFA1 receptor and 0.76 for GPR120).	Carboxylic Acids	79-94	free fatty acid receptor 4	Mus musculus	154-160
23453218-3	2013	An X-ray analysis of 8d showed that the inserted phenyl ring well mimicked the folded methylene linker of the gamma hydroxy carboxylic acid moiety but the carboxylic acid of 8d interacted with VDR in a different manner from gamma hydroxy carboxylic acids.	Carboxylic Acids	124-139	vitamin D receptor	Rattus norvegicus	193-196
23433519-8	2013	The binding energy of Pb(II) ion toward carboxylic acid, carbonyl, and hydroxyl groups was calculated.	Carboxylic Acids	40-55	submaxillary gland androgen regulated protein 3B	Homo sapiens	22-28
22639973-6	2013	KEY RESULTS Calculated hydrogen bonding energies between a series of synthetic carboxylic acid compounds and the homology models of the FFA1 receptor and GPR120, using docking simulations, correlated well with the effects of the compounds on ERK phosphorylation in transfected cells (R(2) = 0.65 for FFA1 receptor and 0.76 for GPR120).	Carboxylic Acids	79-94	mitogen-activated protein kinase 1	Mus musculus	242-245
22639973-6	2013	KEY RESULTS Calculated hydrogen bonding energies between a series of synthetic carboxylic acid compounds and the homology models of the FFA1 receptor and GPR120, using docking simulations, correlated well with the effects of the compounds on ERK phosphorylation in transfected cells (R(2) = 0.65 for FFA1 receptor and 0.76 for GPR120).	Carboxylic Acids	79-94	free fatty acid receptor 4	Mus musculus	327-333
23386702-1	2013	UNLABELLED: Carboxylesterases hydrolyze esters, amides, and thioesters to produce carboxylic acids and resulting alcohols, amines, and thiols, respectively.	Carboxylic Acids	82-98	carboxylesterase 1	Homo sapiens	12-29
23386702-2	2013	Uridine 5"-diphosphate- glucuronosyltransferases are colocalized with carboxylesterases and have the potential to further metabolize carboxylic acids to acyl glucuronides, but it is currently unknown if acyl glucuronides, being esters, also interact with carboxylesterases.	Carboxylic Acids	133-149	carboxylesterase 1	Homo sapiens	70-87
23386702-2	2013	Uridine 5"-diphosphate- glucuronosyltransferases are colocalized with carboxylesterases and have the potential to further metabolize carboxylic acids to acyl glucuronides, but it is currently unknown if acyl glucuronides, being esters, also interact with carboxylesterases.	Carboxylic Acids	133-149	carboxylesterase 1	Homo sapiens	255-272
23454516-3	2013	Most inhibitors of AKR1C3 are carboxylic acids, whose transport into cells is likely dominated by carrier-mediated processes.	Carboxylic Acids	30-46	aldo-keto reductase family 1 member C3	Homo sapiens	19-25
23350970-0	2013	Zn(OTf)2-promoted chemoselective esterification of hydroxyl group bearing carboxylic acids.	Carboxylic Acids	74-90	POU class 2 homeobox 2	Homo sapiens	3-8
23295227-1	2013	Only one crystal structure is currently available for tumor marker AKR1B10, complexed with NADP(+) and tolrestat, which is an aldose reductase inhibitor (ARI) of the carboxylic acid type.	Carboxylic Acids	166-181	aldo-keto reductase family 1 member B10	Homo sapiens	67-74
22931212-4	2013	In hepatocytes, PT predominantly formed three ribose conjugates: Rib-C1, the ribose conjugate (Rib-C2), and the carboxylic acid of Rib-C2 (Rib-C3).	Carboxylic Acids	112-127	RIB43A domain with coiled-coils 2	Rattus norvegicus	131-137
23295227-1	2013	Only one crystal structure is currently available for tumor marker AKR1B10, complexed with NADP(+) and tolrestat, which is an aldose reductase inhibitor (ARI) of the carboxylic acid type.	Carboxylic Acids	166-181	aldo-keto reductase family 1 member B	Homo sapiens	126-142
23295229-1	2013	Aldehyde dehydrogenase 1 (ALDH1A1) catalyzes the oxidation of toxic aldehydes to carboxylic acids.	Carboxylic Acids	81-97	aldehyde dehydrogenase 1 family member A1	Homo sapiens	26-33
23067318-2	2012	Methyl ester prodrug 14 is hydrolyzed in vivo to the corresponding carboxylic acid 15, a potent and selective S1P(1) antagonist.	Carboxylic Acids	67-82	sphingosine-1-phosphate receptor 1	Rattus norvegicus	110-116
23317570-1	2013	The structure-activity relationship studies of a novel series of carboxylic acid derivatives of pyridine-carboxamides as DGAT-1 inhibitors is described.	Carboxylic Acids	65-80	diacylglycerol O-acyltransferase 1	Homo sapiens	121-127
23177256-4	2013	Importantly, the carboxylic acid of JY-3-094 improves the physicochemical properties of the lead compound, which will facilitate the incorporation of additional hydrophobicity that might enhance Myc inhibitory activity further still.	Carboxylic Acids	17-32	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	195-198
24348091-5	2013	Anti-Kv 11.1 monoclonal antibodies (Kv 11.1-Mab) were further linked to the terminal carboxylic acid groups.	Carboxylic Acids	85-100	potassium voltage-gated channel modifier subfamily V member 2	Homo sapiens	5-12
24348091-5	2013	Anti-Kv 11.1 monoclonal antibodies (Kv 11.1-Mab) were further linked to the terminal carboxylic acid groups.	Carboxylic Acids	85-100	potassium voltage-gated channel modifier subfamily V member 2	Homo sapiens	36-43
23111421-1	2013	INTRODUCTION: Carboxylesterase 1 (CES1) is the primary enzyme responsible for converting clopidogrel into biologically inactive carboxylic acid metabolites.	Carboxylic Acids	128-143	carboxylesterase 1	Homo sapiens	14-32
23111421-1	2013	INTRODUCTION: Carboxylesterase 1 (CES1) is the primary enzyme responsible for converting clopidogrel into biologically inactive carboxylic acid metabolites.	Carboxylic Acids	128-143	carboxylesterase 1	Homo sapiens	34-38
23084275-4	2012	As a result, we could generate compounds showing the PPAR alpha/gamma dual activity, especially among which compound 22e had a franylmethyl group on the linker and 2,6-dimethyl phenyl ring at the carboxylic acid head group furnishing a highly potent dual agonist activity, together with a great glucose lowering effect.	Carboxylic Acids	196-211	peroxisome proliferator activated receptor alpha	Mus musculus	53-63
22821423-4	2013	However, full-length HBx was found in only 27 (54%) of the HCC tumors, whereas natural carboxylic acid (COOH)-truncated HBx was found in the remaining 23 (46%) tumors.	Carboxylic Acids	87-102	X protein	Hepatitis B virus	120-123
23136113-9	2012	Oxidation of the aldehyde functionality of ent-2 gave a carboxylic acid that was converted into the corresponding N-hexyl amide.	Carboxylic Acids	56-71	solute carrier family 29 member 2	Homo sapiens	43-48
23137448-3	2012	Here we describe the identification of a group of N-(methylsulfonyl)amides, derived from PPARalpha agonist carboxylic acids.	Carboxylic Acids	107-123	peroxisome proliferator activated receptor alpha	Homo sapiens	89-98
23025585-5	2012	The remaining free carboxylic acid groups were modified with sulfobetaine moieties, and anti-EpCAM antibody was finally introduced.	Carboxylic Acids	19-34	epithelial cell adhesion molecule	Homo sapiens	93-98
23018277-3	2012	The literature on phloem has been reviewed to determine the appropriate concentrations for the metal ions, amino acids and carboxylic acids in phloem sap.	Carboxylic Acids	123-139	SH2 domain containing 1A	Homo sapiens	150-153
22992107-2	2012	We aimed to create mPGES-1 inhibitors by modifying the structure of NSAIDs by replacing the carboxylic acid functionality by sulfonamide moieties.	Carboxylic Acids	92-107	prostaglandin E synthase	Mus musculus	19-26
22989032-4	2012	Selective inhibition of intestinal MTP is achieved via rapid hydrolysis of its ester linkage by liver-specific carboxylesterase(s), resulting in the formation of an inactive carboxylic acid metabolite 1.	Carboxylic Acids	174-189	microsomal triglyceride transfer protein	Homo sapiens	35-38
22700535-1	2012	The stereoselective epoxidation of styrene was catalyzed by H(2) O(2) -dependent cytochrome P450(SPalpha)  in the presence of carboxylic acids as decoy molecules.	Carboxylic Acids	126-142	CD5 molecule like	Homo sapiens	92-105
22991924-6	2012	Terminal triols and tetraols respectively underwent cleavage of their C-2 and C-3 moieties to afford their corresponding two- and three-carbon-unit-shorter carboxylic acids.	Carboxylic Acids	156-172	complement C2	Homo sapiens	70-81
22803810-4	2012	Structure-activity guided replacement of the A-ring carboxylic acid with halogens and incorporation of fluorine at the pyrimidine 5-position led to highly potent inhibitors of Aurora A that bind in a DFG-out conformation.	Carboxylic Acids	52-67	aurora kinase A	Homo sapiens	176-184
22829543-9	2012	CYP3A4 was the predominant enzyme involved in the oxidative metabolism of Rh2, whereas alcohol dehydrogenase and aldehyde dehydrogenase mainly catalyzed the metabolic conversion of alcohol to the corresponding carboxylic acid.	Carboxylic Acids	210-225	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	0-6
22829543-9	2012	CYP3A4 was the predominant enzyme involved in the oxidative metabolism of Rh2, whereas alcohol dehydrogenase and aldehyde dehydrogenase mainly catalyzed the metabolic conversion of alcohol to the corresponding carboxylic acid.	Carboxylic Acids	210-225	Rh associated glycoprotein	Homo sapiens	74-108
22927238-5	2012	Our approach also uncovered a periodic trend of increased binding and homodimerization of RXR when substituting a halogen atom for a proton ortho to the carboxylic acid on 1.	Carboxylic Acids	153-168	retinoid X receptor alpha	Homo sapiens	90-93
22835722-1	2012	A series of carboxylic acids carrying various functionalization on C-7 of their common 3H-spiro[benzofuran-2,1"-cyclohexane] skeleton were synthesized from filifolinol, as analogs of the natural Complement inhibitor K-76 COOH.	Carboxylic Acids	12-28	keratin 76	Homo sapiens	216-220
22554767-2	2012	Polymer-CPT conjugates (PCCs), which consisted of CPT-20-glycinate and poly(organophosphazene) bearing carboxylic acid, were synthesized, characterized for physicochemical properties, in vitro degradation and CPT release behaviors from the PCC, and evaluated their anticancer activity.	Carboxylic Acids	103-118	crystallin gamma D	Homo sapiens	24-27
22352697-13	2012	The combined results also suggest that diester prodrugs which conjugated two carboxylic acid groups of proper amino acid promoieties and parent drug through a linker can be used for PepT1-targeted prodrug design.	Carboxylic Acids	77-92	solute carrier family 15 member 1	Rattus norvegicus	182-187
22608962-2	2012	Optimisation of potency and ligand lipophilicity efficiency (LLE) resulted in a carboxylic acid containing clinical candidate 53 (AZD3988), which demonstrated excellent DGAT-1 potency (0.6 nM), good pharmacokinetics and pre-clinical in vivo efficacy that could be rationalised through a PK/PD relationship.	Carboxylic Acids	80-95	diacylglycerol O-acyltransferase 1	Homo sapiens	169-175
22966598-5	2012	Among diamine linkers with different chain lengths (C-4, C-8, and C-12), C-8 diamine (1,8-diaminooctane) produced the maximal PL intensity for QD-bound hydrogels, indicating that C-8 diamine was an optimal cross-linker between hydrogels and QDs with surface carboxylic acid groups.	Carboxylic Acids	258-273	homeobox C8	Homo sapiens	73-76
22966598-5	2012	Among diamine linkers with different chain lengths (C-4, C-8, and C-12), C-8 diamine (1,8-diaminooctane) produced the maximal PL intensity for QD-bound hydrogels, indicating that C-8 diamine was an optimal cross-linker between hydrogels and QDs with surface carboxylic acid groups.	Carboxylic Acids	258-273	homeobox C8	Homo sapiens	73-76
22364710-2	2012	It was clarified that the interaction between carbonyl/carboxylic acid groups of PCL and the HAp nanoparticles at an oil-water interface played a crucial role in the preparation of the stable Pickering-type emulsions and the HAp nanoparticle-armored microspheres.	Carboxylic Acids	55-70	retinoic acid receptor beta	Homo sapiens	93-96
22500641-3	2012	Modified prolines with aromatic groups syn to the carboxylic acid are better catalysts than those with small hydrophobic groups (1a is 43.5 times faster than 1f).	Carboxylic Acids	50-65	synemin	Homo sapiens	39-42
22380712-7	2012	Conversion of the carboxylic acid functionality to amides and long-chain analogues, however, yielded bioactive compounds that induced the heat shock response (HSR) and antioxidant response and inhibited Hsp90 activity.	Carboxylic Acids	18-33	heat shock protein 90 alpha family class A member 1	Homo sapiens	203-208
22364710-2	2012	It was clarified that the interaction between carbonyl/carboxylic acid groups of PCL and the HAp nanoparticles at an oil-water interface played a crucial role in the preparation of the stable Pickering-type emulsions and the HAp nanoparticle-armored microspheres.	Carboxylic Acids	55-70	retinoic acid receptor beta	Homo sapiens	225-228
22435596-1	2012	Although tetrathiafulvalene derivatives (TTFs) have been used as the redox-active unit in a lot of ion responsive receptors, only a few such examples of TTF carboxylic acids have been reported, especially about the responses to neutral organic molecules.	Carboxylic Acids	157-173	ras homolog family member H	Homo sapiens	41-44
22424978-0	2012	Discovery of novel and potent heterocyclic carboxylic acid derivatives as protein tyrosine phosphatase 1B inhibitors.	Carboxylic Acids	43-58	protein tyrosine phosphatase, non-receptor type 1	Mus musculus	74-105
22196621-4	2012	Herein, we report structure-activity studies on a carboxylic acid containing series of glucokinase activators with preferential activity in hepatocytes versus pancreatic beta-cells.	Carboxylic Acids	50-65	glucokinase	Homo sapiens	87-98
22209730-0	2012	A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) gamma agonists: design and synthesis of benzylpyrazole acylsulfonamides.	Carboxylic Acids	42-57	peroxisome proliferator activated receptor alpha	Homo sapiens	81-123
22209730-0	2012	A new class of non-thiazolidinedione, non-carboxylic-acid-based highly selective peroxisome proliferator-activated receptor (PPAR) gamma agonists: design and synthesis of benzylpyrazole acylsulfonamides.	Carboxylic Acids	42-57	peroxisome proliferator activated receptor alpha	Homo sapiens	125-129
22209730-1	2012	Herein, we describe the design, synthesis, and structure-activity relationships of novel benzylpyrazole acylsulfonamides as non-thiazolidinedione (TZD), non-carboxylic-acid-based peroxisome proliferator-activated receptor (PPAR) gamma agonists.	Carboxylic Acids	157-172	peroxisome proliferator activated receptor alpha	Homo sapiens	179-221
21893678-6	2011	In the planar structure of ox-LGD(2), H8 and H12 of LGD(2) were dehydrogenated and the C9 aldehyde was oxidized to a carboxylic acid, which formed a lactone ring with the hydrated ketone at C11.	Carboxylic Acids	117-132	polymerase (RNA) III (DNA directed) polypeptide K	Mus musculus	190-193
22894115-2	2012	Photocatalytic reduction of PFOA with beta-Ga2O3 in anoxic aqueous solution was investigated for the first time, and the results showed that the photoinduced electron (e(cb-)) coming from the beta-Ga2O3 conduction band was the major degradation substance for PFOA, and shorter-chain perfluorinated carboxylic acids (PFCAs, CnF2n+i1COOH, 1 < or = n < or = 6) were the dominant products.	Carboxylic Acids	298-314	NPHS1 adhesion molecule, nephrin	Homo sapiens	323-326
21920581-3	2011	The founding members of the family consist of biotin carboxylase, d-ala-d-ala ligase and glutathione synthetase, all of which catalyze the ATP-assisted reaction of a carboxylic acid with a nucleophile via the formation of an acylphosphate intermediate.	Carboxylic Acids	166-181	methylcrotonyl-CoA carboxylase subunit 2	Homo sapiens	46-64
21920581-3	2011	The founding members of the family consist of biotin carboxylase, d-ala-d-ala ligase and glutathione synthetase, all of which catalyze the ATP-assisted reaction of a carboxylic acid with a nucleophile via the formation of an acylphosphate intermediate.	Carboxylic Acids	166-181	glutathione synthetase	Homo sapiens	89-111
24900284-0	2011	Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids.	Carboxylic Acids	74-90	prostaglandin D2 receptor 2	Homo sapiens	31-36
21972974-8	2011	Conversely, the docked MMP9-D2 structure shows hydrophobic and hydrogen bonding between the ligand"s morpholine substituent and second carboxylic acid group with Leu187 and an amide, respectively.	Carboxylic Acids	135-150	matrix metallopeptidase 9	Homo sapiens	23-27
21887445-4	2011	On the other hand, a less-hindered carboxylic acid, such as 3-phenylpropanoic acid, functioned as a better acyl donor for the kinetic resolution of racemic secondary benzylic alcohols having branched aliphatic alkyl chains at the C-1 positions.	Carboxylic Acids	35-50	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	230-233
24900284-0	2011	Discovery of a Novel Series of CRTH2 (DP2) Receptor Antagonists Devoid of Carboxylic Acids.	Carboxylic Acids	74-90	prostaglandin D2 receptor 2	Homo sapiens	38-41
24900284-2	2011	Most CRTH2 antagonists known to date possess a carboxylic acid moiety, which is essential for binding.	Carboxylic Acids	47-62	prostaglandin D2 receptor 2	Homo sapiens	5-10
24900284-8	2011	Taken together, these data show that compounds devoid of carboxylic acid groups could represent an interesting alternative to current CRTH2 antagonists in development.	Carboxylic Acids	57-72	prostaglandin D2 receptor 2	Homo sapiens	134-139
21872056-9	2011	Linear response towards carboxylic acids was observed in the concentration range of 10(-4) to 10(-2)mold m(-3), with the slopes in the range of -110 to -150 mV dec(-1) (for acetate(-) and butyrate(-), respectively).	Carboxylic Acids	24-40	deleted in esophageal cancer 1	Homo sapiens	160-166
21459068-1	2011	Mitochondrial aldehyde dehydrogenase (ALDH2) is an enzyme that detoxifies aldehydes to carboxylic acids.	Carboxylic Acids	87-103	aldehyde dehydrogenase 2, mitochondrial	Mus musculus	38-43
21667987-0	2011	Stereospecific synthesis of syn-alpha-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids.	Carboxylic Acids	120-136	synemin	Homo sapiens	15-18
21667987-0	2011	Stereospecific synthesis of syn-alpha-oximinoamides by a three-component reaction of isocyanides, syn-chlorooximes, and carboxylic acids.	Carboxylic Acids	120-136	synemin	Homo sapiens	28-31
21667987-1	2011	A stereospecific multicomponent reaction among isocyanides, syn-chlorooximes, and carboxylic acids provides an efficient synthesis of biologically relevant syn-alpha-oximinoamides.	Carboxylic Acids	82-98	synemin	Homo sapiens	121-124
21185811-1	2011	Antiquitin (ALDH7) is a member of the aldehyde dehydrogenase superfamily which oxidizes various aldehydes to form the corresponding carboxylic acids.	Carboxylic Acids	132-148	aldehyde dehydrogenase 9 family member A1	Homo sapiens	12-17
21187079-3	2011	The oxidation of FOH and GGOH into their aldehyde intermediates were mainly mediated by alcohol dehydrogenases 1 (in the liver and colon) and 7 (in the stomach and lung), and the subsequent step into the carboxylic acids was catalyzed by a microsomal aldehyde dehydrogenase.	Carboxylic Acids	204-220	aldehyde dehydrogenase 3 family member A2	Homo sapiens	240-273
21742490-2	2011	Here we report the identification of N-(phenylsulfonyl)amides containing the benzothiazole scaffold, a novel class of potent PPARalpha antagonists obtained from chemical modification of carboxylic acid agonists.	Carboxylic Acids	186-201	peroxisome proliferator activated receptor alpha	Homo sapiens	125-134
21645689-2	2011	Carboxylic acid haptens of X, IX and 8-PN were synthesized by linking a spacer to their C4"-OH group followed by subsequent coupling to bovine serum albumin (BSA) to form conjugates that were employed as immunogens in BALB/c mice to raise antibodies.	Carboxylic Acids	0-15	albumin	Mus musculus	143-156
21232642-6	2011	In the second protocol the formation of an amide bond between carboxylic acid-coated gold nanoparticles and free surface amines of catalase using carbodiimide chemistry was performed.	Carboxylic Acids	62-77	catalase	Homo sapiens	131-139
21381756-4	2011	Most synthetic retinoid ligands are based on the retinoid scaffold and thus have similarities to the natural ligand with all previously disclosed RAR ligands having a carboxylic acid that makes a critical ionic bridge within the ligand binding domain of the receptors.	Carboxylic Acids	167-182	retinoic acid receptor alpha	Homo sapiens	146-149
21276780-1	2011	Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids.	Carboxylic Acids	75-91	aldehyde dehydrogenase 2 family member	Homo sapiens	0-24
21276780-1	2011	Aldehyde dehydrogenase 2 (ALDH2) catalyzes oxidation of toxic aldehydes to carboxylic acids.	Carboxylic Acids	75-91	aldehyde dehydrogenase 2 family member	Homo sapiens	26-31
21507633-4	2011	X-ray structures of the inhibitor/Pim-1 binding complex reveal important salt-bridge and hydrogen bond interactions mediated by the compound"s carboxylic acid and amino groups.	Carboxylic Acids	143-158	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	34-39
21220428-5	2011	Structure-activity relationship analysis allowed formulation of a general rule to predict selectivity for small carboxylic acids at the orthosteric binding site where ligands with substituted sp(3)-hybridized alpha-carbons preferentially activate FFA3, whereas ligands with sp(2)- or sp-hybridized alpha-carbons prefer FFA2.	Carboxylic Acids	112-128	free fatty acid receptor 2	Homo sapiens	319-323
21413799-0	2011	Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.	Carboxylic Acids	27-42	diacylglycerol O-acyltransferase 1	Rattus norvegicus	116-148
21365101-1	2011	In our pursuit of an efficient, protecting-group-free synthesis of the dual CCK1/CCK2 receptor antagonist 1, we have developed chemoselective conditions for sulfonamide formation reaction in pure water and a PhNMe(2) mediated carboxamide formation, both in the presence of a carboxylic acid.	Carboxylic Acids	275-290	C-C motif chemokine ligand 28	Homo sapiens	76-80
21429746-1	2011	The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-dependent inhibition and hERG affinity) relative to analogous non-zwitterionic inhibitors of the past (i.e., 3).	Carboxylic Acids	23-38	renin	Homo sapiens	184-189
21429746-1	2011	The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-dependent inhibition and hERG affinity) relative to analogous non-zwitterionic inhibitors of the past (i.e., 3).	Carboxylic Acids	23-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	236-242
21429746-1	2011	The incorporation of a carboxylic acid within in a series of 3-amido-4-aryl substituted piperidines (represented by general structure 32) led to the discovery of potent, zwitterionic, renin inhibitors with improved off-target profiles (CYP3A4 time-dependent inhibition and hERG affinity) relative to analogous non-zwitterionic inhibitors of the past (i.e., 3).	Carboxylic Acids	23-38	ETS transcription factor ERG	Homo sapiens	273-277
22291761-0	2011	Carboxylic acid derivatives of histone deacetylase inhibitors induce full length SMN2 transcripts: a promising target for spinal muscular atrophy therapeutics.	Carboxylic Acids	0-15	histone deacetylase 9	Homo sapiens	31-50
22291761-0	2011	Carboxylic acid derivatives of histone deacetylase inhibitors induce full length SMN2 transcripts: a promising target for spinal muscular atrophy therapeutics.	Carboxylic Acids	0-15	survival of motor neuron 2, centromeric	Homo sapiens	81-85
21296151-5	2011	In order to study the binding mode of this compound, three derivatives are synthesized to get more detail about the structure-activity relationship, molecular docking and the NMR spectra indicate that similar to most PPARgamma ligand, the carboxylic acid group is an important moiety for HL005 and contributes strong interaction with PPARgamma.	Carboxylic Acids	239-254	peroxisome proliferator activated receptor gamma	Homo sapiens	217-226
21296151-5	2011	In order to study the binding mode of this compound, three derivatives are synthesized to get more detail about the structure-activity relationship, molecular docking and the NMR spectra indicate that similar to most PPARgamma ligand, the carboxylic acid group is an important moiety for HL005 and contributes strong interaction with PPARgamma.	Carboxylic Acids	239-254	peroxisome proliferator activated receptor gamma	Homo sapiens	334-343
21053011-11	2011	The recombinant ALDH10A9 enzyme was shown to oxidize betaine aldehyde, 4-aminobutyraldehyde and 3-aminopropionaldehyde to their corresponding carboxylic acids.	Carboxylic Acids	142-158	aldehyde dehydrogenase 10A9	Arabidopsis thaliana	16-24
21146503-2	2011	The carboxylic acid group of the fatty acid was found to form a salt bridge with Arg(217) of HLE while unsaturation interacted with Phe(192) and Val(216) at the S(3) subsite, and alkyl end group occupied S(1) subsite.	Carboxylic Acids	4-19	elastase, neutrophil expressed	Homo sapiens	93-96
21277203-5	2011	The AKR1C3 inhibitory potency of the 4"-substituted 3-(phenylamino)benzoic acids shows a linear correlation with both electronic effects of substituents and the pK(a) of the carboxylic acid and secondary amine groups, which are interdependent.	Carboxylic Acids	174-189	aldo-keto reductase family 1 member C3	Homo sapiens	4-10
21130617-1	2011	An air-treated G4.5 poly(amidoamine) (PAMAM) dendrimer displayed the enhanced fluorescence enough to be utilized as a fluorescence marker to visualize avidin-biotin affinity: On a fluorescence microscopic image, the avidin labeled by a fluorescent G4.5 PAMAM dendrimer was observed to be selectively bound on the biotin pattern that was prepared by amide-bonding of biotin on a carboxylic acid-terminated self-assembled monolayer and in turn by UV-irradiation with a photomask on the monolayer.	Carboxylic Acids	378-393	tafazzin, phospholipid-lysophospholipid transacylase	Homo sapiens	15-19
21163906-3	2011	A structure-activity relationship for PFAAs was observed, where eight to ten fluorinated carbons and a carboxylic acid end group were optimal for maximal Vtg induction.	Carboxylic Acids	103-118	putative uncharacterized protein LOC400499	Homo sapiens	154-157
21153583-4	2011	Nanoparticle bioconjugation with highly purified human plasma fibronectin (Fn) is mediated by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, resulting in an amide linkage between the carboxylic acid-terminated surface of the nanoparticle and the primary amine of Fn.	Carboxylic Acids	209-224	fibronectin 1	Homo sapiens	62-73
21153583-4	2011	Nanoparticle bioconjugation with highly purified human plasma fibronectin (Fn) is mediated by 1-ethyl-3-(3-dimethylaminopropyl) carbodiimide and N-hydroxysuccinimide, resulting in an amide linkage between the carboxylic acid-terminated surface of the nanoparticle and the primary amine of Fn.	Carboxylic Acids	209-224	fibronectin 1	Homo sapiens	75-77
22041073-0	2011	Discovery of a novel acyl-CoA: cholesterol acyltransferase inhibitor: the synthesis, biological evaluation, and reduced adrenal toxicity of (4-phenylcoumarin)acetanilide derivatives with a carboxylic acid moiety.	Carboxylic Acids	189-204	sterol O-acyltransferase 1	Homo sapiens	21-58
20843536-7	2010	An in silico molecular docking model of 4-CB-2",5"-H(2)Q in the peroxidase site of hPGHS-2 together with ab initio quantum mechanical studies indicate that the close proximity of a negatively charged carboxylic acid in the peroxidase active site may be responsible for the observed perturbation in the spectrum.	Carboxylic Acids	200-215	prostaglandin-endoperoxide synthase 2	Homo sapiens	83-90
20925583-6	2010	These results could be helpful in investigating the potential association of GLYAT variants with an incidence of reduced efficiency in xenobiotic carboxylic acids detoxification in humans.	Carboxylic Acids	146-162	glycine-N-acyltransferase	Homo sapiens	77-82
20808936-9	2010	Several biological processes such as mitochondrial metabolic pathways, lipid metabolic and catabolic processes, lipid biosynthetic processes, carboxylic acid metabolic processes, iron ion binding and glutathione S-transferases were downregulated after leptin administration.	Carboxylic Acids	142-157	leptin	Mus musculus	252-258
20942492-0	2010	Cu(OTf)(2)-mediated Chan-Lam reaction of carboxylic acids to access phenolic esters.	Carboxylic Acids	41-57	POU class 2 homeobox 2	Homo sapiens	0-9
20942492-1	2010	A Cu(OTf)(2)-mediated Chan-Lam reaction of carboxylic acids with arylboronic acids is described.	Carboxylic Acids	43-59	POU class 2 homeobox 2	Homo sapiens	2-11
21874153-0	2010	Effect of Inhibiting Histone Deacetylase with Short-Chain Carboxylic Acids and Their Hydroxamic Acid Analogs on Vertebrate Development and Neuronal Chromatin.	Carboxylic Acids	58-74	histone deacetylase 9	Homo sapiens	21-40
21874153-1	2010	Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in human cervical carcinoma Hela cells and primary cultures from mouse forebrain, and a whole animal (Xenopus laevis) developmental assay.	Carboxylic Acids	0-16	histone deacetylase 9	Homo sapiens	55-74
21874153-1	2010	Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in human cervical carcinoma Hela cells and primary cultures from mouse forebrain, and a whole animal (Xenopus laevis) developmental assay.	Carboxylic Acids	0-16	histone deacetylase 9	Homo sapiens	76-80
21874153-1	2010	Carboxylic acids with known central nervous system and histone deacetylase (HDAC) inhibitory activities were converted to hydroxamic acids and tested using a suite of in vitro biochemical assays with recombinant HDAC isoforms, cell based assays in human cervical carcinoma Hela cells and primary cultures from mouse forebrain, and a whole animal (Xenopus laevis) developmental assay.	Carboxylic Acids	0-16	histone deacetylase 9	Homo sapiens	212-216
20886132-4	2010	(1)H, {(1)H}-(31)P HPDec MAS, CP MAS and 2D {(1)H}-(31)P CP-HETCOR MAS NMR experiments suggest that carboxylic acids are localized on the apatite nanocrystallite surface, resulting in the formation of a disordered outer layer.	Carboxylic Acids	100-116	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	19-28
20823284-0	2010	Preclinical characterization of BI 201335, a C-terminal carboxylic acid inhibitor of the hepatitis C virus NS3-NS4A protease.	Carboxylic Acids	56-71	KRAS proto-oncogene, GTPase	Homo sapiens	107-110
21155384-6	2010	Meanwhile, the design of 2"-carbethoxy-biphenylylmethyl analogues (XIa,b) was based upon the molecular modeling simulation fitting of their carboxylic acid bioprecursors with the previously generated and validated Ang II receptor antagonist hypothesis.	Carboxylic Acids	140-155	angiogenin	Felis catus	214-217
20715823-1	2010	C-Terminal carboxylic acid containing inhibitors of the NS3 protease are reported.	Carboxylic Acids	11-26	KRAS proto-oncogene, GTPase	Homo sapiens	56-59
20430399-8	2010	Moreover, by using specially labeled spin-probes based on stearic acids, functionalized at different separations from the carboxylic acid group, it was possible to interrogate the molecular physical behavior of surfactant shells at different distances from carbonate surfaces.	Carboxylic Acids	122-137	spindlin 1	Homo sapiens	37-41
20435140-5	2010	We speculated that the carboxylic acid of lithocholic acid could be recognized by Arg-274 in the ligand-binding domain of VDR.	Carboxylic Acids	23-38	vitamin D receptor	Homo sapiens	122-125
20518495-2	2010	They all start from the carboxylic acid [Fe(eta(5)-C(5)H(4)COOH)(eta(6)-C(6)Me(6))][PF(6)], 2, or its acyl chloride derivative [Fe(eta(5)-C(5)H(4)COCl)(eta(6)-C(6)Me(6))][PF(6)], 3.	Carboxylic Acids	24-39	endothelin receptor type A	Homo sapiens	44-47
20518495-2	2010	They all start from the carboxylic acid [Fe(eta(5)-C(5)H(4)COOH)(eta(6)-C(6)Me(6))][PF(6)], 2, or its acyl chloride derivative [Fe(eta(5)-C(5)H(4)COCl)(eta(6)-C(6)Me(6))][PF(6)], 3.	Carboxylic Acids	24-39	endothelin receptor type A	Homo sapiens	65-68
20518495-2	2010	They all start from the carboxylic acid [Fe(eta(5)-C(5)H(4)COOH)(eta(6)-C(6)Me(6))][PF(6)], 2, or its acyl chloride derivative [Fe(eta(5)-C(5)H(4)COCl)(eta(6)-C(6)Me(6))][PF(6)], 3.	Carboxylic Acids	24-39	endothelin receptor type A	Homo sapiens	65-68
20518495-2	2010	They all start from the carboxylic acid [Fe(eta(5)-C(5)H(4)COOH)(eta(6)-C(6)Me(6))][PF(6)], 2, or its acyl chloride derivative [Fe(eta(5)-C(5)H(4)COCl)(eta(6)-C(6)Me(6))][PF(6)], 3.	Carboxylic Acids	24-39	endothelin receptor type A	Homo sapiens	65-68
20450210-2	2010	In the present study, the density functional theory (DFT method), B3P86/6-311++G(2df,2p)//B3LYP/6-31+G(d), is found to be reliable to predict the C-COOH BDE of various structurally unrelated carboxylic acids.	Carboxylic Acids	191-207	homeobox D13	Homo sapiens	153-156
20685480-1	2010	Graphene-CdS (G-CdS) nanocomposites were successfully prepared by CdS nanocrystals (CdS NCs) formed in situ on the surface of graphene sheets, using graphene oxide (GO) sheets with rich negatively charged carboxylic acid groups as starting materials.	Carboxylic Acids	205-220	CDP-diacylglycerol synthase 1	Homo sapiens	9-12
20450210-6	2010	Also with the C-COOH BDE data obtained in this work, an excellent linear relationship has been found between the C-COOH BDE of carboxylic acids and the C-H BDE of their hydrocarbon analogues.	Carboxylic Acids	127-143	homeobox D13	Homo sapiens	120-123
20446713-1	2010	A facile NHC-mediated reaction of aromatic aldehydes with carbon dioxide leading to carboxylic acids is described.	Carboxylic Acids	84-100	high mobility group nucleosomal binding domain 4	Homo sapiens	9-12
20450210-4	2010	With the authorized theoretical protocol in hand, an extensive C-COOH BDE scale containing over 100 carboxylic acids has been established.	Carboxylic Acids	100-116	homeobox D13	Homo sapiens	70-73
20450210-6	2010	Also with the C-COOH BDE data obtained in this work, an excellent linear relationship has been found between the C-COOH BDE of carboxylic acids and the C-H BDE of their hydrocarbon analogues.	Carboxylic Acids	127-143	homeobox D13	Homo sapiens	21-24
20450210-6	2010	Also with the C-COOH BDE data obtained in this work, an excellent linear relationship has been found between the C-COOH BDE of carboxylic acids and the C-H BDE of their hydrocarbon analogues.	Carboxylic Acids	127-143	homeobox D13	Homo sapiens	120-123
20397156-7	2010	With vitamin B(3), a carboxylic acid, titration of DAB-G3-16-NH(2) shows that only six peripheral amino groups are protonated on average, even with excess vitamin B(3), because protonation is all the more difficult due to increased charge repulsion, as positive charges accumulate around the dendrimer.	Carboxylic Acids	21-36	immunoglobulin kappa variable 4-1	Homo sapiens	163-167
20405834-7	2010	Furthermore, it was demonstrated that 7-hydroxyraloxifene, which was previously believed to be a typical O(2)-derived metabolite of CYP3A4, is in fact produced by a highly unusual hydrolysis pathway from a putative ester, formed by the conjugation of raloxifene diquinone methide with a carboxylic acid moiety of CYP3A4, or other proteins in the reconstituted system.	Carboxylic Acids	287-302	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	132-138
20405834-7	2010	Furthermore, it was demonstrated that 7-hydroxyraloxifene, which was previously believed to be a typical O(2)-derived metabolite of CYP3A4, is in fact produced by a highly unusual hydrolysis pathway from a putative ester, formed by the conjugation of raloxifene diquinone methide with a carboxylic acid moiety of CYP3A4, or other proteins in the reconstituted system.	Carboxylic Acids	287-302	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	313-319
20452228-0	2010	Identification of new non-carboxylic acid containing inhibitors of aldose reductase.	Carboxylic Acids	26-41	aldo-keto reductase family 1 member B	Homo sapiens	67-83
20452228-1	2010	Non-carboxylic acid containing bioisosteres of (5-arylidene-2,4-dioxothiazolidin-3-yl)acetic acids, which are active as aldose reductase (ALR2) inhibitors, were designed by replacing the carboxylic group with the trifluoromethyl ketone moiety.	Carboxylic Acids	4-19	aldo-keto reductase family 1 member B	Homo sapiens	120-136
20452228-1	2010	Non-carboxylic acid containing bioisosteres of (5-arylidene-2,4-dioxothiazolidin-3-yl)acetic acids, which are active as aldose reductase (ALR2) inhibitors, were designed by replacing the carboxylic group with the trifluoromethyl ketone moiety.	Carboxylic Acids	4-19	aldo-keto reductase family 1 member B	Homo sapiens	138-142
20411940-1	2010	The role of selected carboxylic acids and their potential to influence the glycation pattern and the enzymatic activity of lysozyme using glucose and ribose were investigated independently of the pH of the reaction medium.	Carboxylic Acids	21-37	lysozyme	Homo sapiens	123-131
20411940-3	2010	The effect of carboxylic acids on the glycation of lysozyme was studied by electrospray ionization mass spectrometry (ESI-MS) and by the measurement of the residual enzyme activity of lysozyme in the glycated samples.	Carboxylic Acids	14-30	lysozyme	Homo sapiens	51-59
20411968-4	2010	Thus, the preferred anti-gauche conformation changes to syn-gauche when the negatively charged carboxylate groups transforms into neutral carboxylic acid.	Carboxylic Acids	138-153	synemin	Homo sapiens	56-59
20405902-5	2010	Also observed as minor constituents are the next two lowest-energy structures, one in which the carboxylic acid (O-)H group hydrogen-bonds to the amino NH(2) group (G-2), and the other where intramolecular hydrogen bonding occurs between the NH(2) and the carboxylic acid O(-H) groups (G-3).	Carboxylic Acids	96-111	crystallin gamma E, pseudogene	Homo sapiens	165-168
20405902-7	2010	The least favored structure, G-3, can be eliminated by annealing the matrix to 35 K. Addition of the first water molecule to G-1 takes place at the carboxylic acid group, with simultaneous hydrogen bonding of the water molecule to the carboxylic acid (C=)O and (O-)H. The results are consistent with the predominance of this structure, although there is evidence for a small amount of a hydrated G-2 structure.	Carboxylic Acids	148-163	BAG cochaperone 6	Homo sapiens	29-32
20405902-7	2010	The least favored structure, G-3, can be eliminated by annealing the matrix to 35 K. Addition of the first water molecule to G-1 takes place at the carboxylic acid group, with simultaneous hydrogen bonding of the water molecule to the carboxylic acid (C=)O and (O-)H. The results are consistent with the predominance of this structure, although there is evidence for a small amount of a hydrated G-2 structure.	Carboxylic Acids	235-250	BAG cochaperone 6	Homo sapiens	29-32
20337491-2	2010	The transformation is carried out by a sequence of denitrogenative formation of iminyl copper species from alpha-azidocarbonyl compounds and their C-C bond cleavage, where molecular oxygen (1 atm) is a prerequisite to achieve the catalytic process and one of the oxygen atoms of O(2) was found to be incorporated into the beta-carbon fragment as a carboxylic acid.	Carboxylic Acids	348-363	ATM serine/threonine kinase	Homo sapiens	192-195
24223494-1	2010	The combination of PPh3/I2 has been shown to be effective for conversion of a range of carboxylic acids to 2 , 3 , and Weinreb amides.	Carboxylic Acids	87-103	protein phosphatase 4 catalytic subunit	Homo sapiens	19-26
20381362-0	2010	Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1" and P4 positions.	Carboxylic Acids	46-61	beta-secretase 1	Homo sapiens	24-29
20381362-0	2010	Design of pentapeptidic BACE1 inhibitors with carboxylic acid bioisosteres at P1" and P4 positions.	Carboxylic Acids	46-61	crystallin gamma F, pseudogene	Homo sapiens	78-88
20381361-0	2010	Structure-activity relationships of bioisosteric replacement of the carboxylic acid in novel androgen receptor pure antagonists.	Carboxylic Acids	68-83	androgen receptor	Mus musculus	93-110
20202668-6	2010	First, the conjugated diene structure of Adda moiety was attacked by hydroxyl radical (OH()) to produce dihydroxylated products, then the hydroxylated 4-5 and/or 6-7 bond of Adda was cleaved into aldehyde or ketone peptide residues, and finally the residues were oxidized into the corresponding carboxylic acids.	Carboxylic Acids	295-311	adducin 1	Homo sapiens	41-45
20338211-0	2010	Effects of carboxylic acids on the uptake of non-transferrin-bound iron by astrocytes.	Carboxylic Acids	11-27	transferrin	Rattus norvegicus	49-60
20359235-1	2010	We show that ligand exchange with short-chain carboxylic acids (formic, acetic, and oxalic acid) can quantitatively remove oleic acid from the surface of PbSe and PbS quantum dot (QD) films to yield p-type, carboxylate-capped QD solids with field-effect hole mobilities in the range of 10(-4)-10(-1) cm(2) V(-1) s(-1).	Carboxylic Acids	46-62	cholinergic receptor muscarinic 3	Homo sapiens	154-157
20202668-6	2010	First, the conjugated diene structure of Adda moiety was attacked by hydroxyl radical (OH()) to produce dihydroxylated products, then the hydroxylated 4-5 and/or 6-7 bond of Adda was cleaved into aldehyde or ketone peptide residues, and finally the residues were oxidized into the corresponding carboxylic acids.	Carboxylic Acids	295-311	adducin 1	Homo sapiens	174-178
20379349-1	2010	Novel retinoids 1-3 containing perillyl alcohol were synthesized through the addition of perillyl alcohol to the activated carboxylic acids (retinoids) promoted by DCC (N, N"-Dicylohexyl cabodiimide).	Carboxylic Acids	123-139	DCC netrin 1 receptor	Homo sapiens	164-167
20175539-6	2010	Carboxylic acid functionalized SPNs were also synthesized and conjugated to bovine serum albumin (BSA) by carbodiimide-mediated chemistry, a key step in the realization of targeted imaging using conjugated polymers.	Carboxylic Acids	0-15	albumin	Homo sapiens	83-96
20060359-8	2010	Two metabolites, phenanthrene-dihydrodiol and naphthalene-1-diol were identified in neutral fraction of phenanthrene degradation by using GC-MS. As a result carboxylic acids and arone were generated during biodegradation of phenanthrene by Flavobacteria FCN2.	Carboxylic Acids	157-173	ficolin 2	Homo sapiens	254-258
20061389-0	2010	Oxidation of N-Nitrosoalkylamines by human cytochrome P450 2A6: sequential oxidation to aldehydes and carboxylic acids and analysis of reaction steps.	Carboxylic Acids	102-118	cytochrome P450 family 2 subfamily A member 6	Homo sapiens	43-62
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Carboxylic Acids	253-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	69-74
20055473-6	2010	The ligands and the copper(II) complexes featuring a carboxylic acid functional group have been conjugated to the tumor targeting peptide bombesin(7-14)-NH(2).	Carboxylic Acids	53-68	gastrin releasing peptide	Homo sapiens	138-146
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Carboxylic Acids	253-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Carboxylic Acids	253-268	complement C2	Homo sapiens	137-140
20061161-4	2010	A molecular modeling study where 8 was docked in the binding site of COX-2 indicated that the p-MeSO(2) COX-2 pharmacophore group on the C-2 phenyl ring is oriented in the vicinity of the COX-2 secondary pocket (Arg(513), Phe(518) and Val(523)) and the carboxylic acid substituent can interact with Ser(530).	Carboxylic Acids	253-268	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	104-109
19670406-6	2009	A liquid formulation of the 15% C8, C9 and C10 mixture in a silicone oil carrier (at 2.8 mg AI cm(-2)) was highly repellent against hungry stable flies in a blood-feeding membrane bioassay for at least 8 h. CONCLUSION: The low toxicity and reasonable activity and persistence of these carboxylic acids make them good candidates for development as protective materials against pest flies in livestock settings.	Carboxylic Acids	285-301	chromosome 12 open reading frame 57	Homo sapiens	43-46
20589074-1	2010	An alternating copolymer of styrene and maleic acid (alt-PSMA) differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties.	Carboxylic Acids	168-183	folate hydrolase 1	Homo sapiens	57-61
20589074-1	2010	An alternating copolymer of styrene and maleic acid (alt-PSMA) differs from other polyanionic antiviral agents in that the negative charges of alt-PSMA are provided by carboxylic acid groups instead of sulfate or sulfonate moieties.	Carboxylic Acids	168-183	folate hydrolase 1	Homo sapiens	147-151
19634003-5	2010	These carboxylic acid groups are expected to enhance calcium ion binding to the cerasome surface, causing an increase of HAp nucleation sites.	Carboxylic Acids	6-21	retinoic acid receptor beta	Homo sapiens	121-124
19902937-3	2009	Our previous SAR studies on the k values of betaGAs derived from o-, m-, and p-substituted benzoic acids demonstrated that the diversity and complexity of the k values were controlled by the electronic and/or steric effects of the parent carboxylic acids.	Carboxylic Acids	238-254	sarcosine dehydrogenase	Homo sapiens	13-16
19902937-4	2009	In the present study, we performed further SAR studies on the k values of 13 betaGAs derived from aralkyl carboxylic acids, focusing on the substituents and stereochemistry at the alpha-position of the parent carboxylic acids.	Carboxylic Acids	106-122	sarcosine dehydrogenase	Homo sapiens	43-46
19862782-6	2009	The high-temperature solid phases of even carboxylic acids are all P2(1)/c with Z=4, the molecules are united into dimers via strong hydrogen bonds.	Carboxylic Acids	42-58	H3 histone pseudogene 16	Homo sapiens	67-72
19635387-2	2009	PRV was coupled to keyhole limpt hemocyanin (KLH) and bovine serum albumin (BSA) via its terminal carboxylic acid group by carbodiimide reagent.	Carboxylic Acids	98-113	albumin	Homo sapiens	61-74
19819138-3	2009	SAR trends clearly reveal a stringent preference for a cyclohexyl group as one of the hydrophobes, and improved activities for carboxylic acid derivatives.	Carboxylic Acids	127-142	sarcosine dehydrogenase	Homo sapiens	0-3
19487247-2	2009	Unlike most UGT1A and UGT2B xenobiotic-metabolizing enzymes, UGT1A4 and UGT2B10 lack the ability to glucuronidate 4-methylumbelliferone (4MU) and 1-naphthol (1NP), both planar phenols, and naproxen (a carboxylic acid).	Carboxylic Acids	201-216	UDP glucuronosyltransferase family 1 member A4	Homo sapiens	61-67
19751053-1	2009	Inter- and intramolecular additions of alkyl radicals, generated by SET photochemical decarboxylation reactions of free carboxylic acids, to electron-deficient alkenes take place under mild conditions as part of efficient routes for the formation of N-Boc gamma-amino acids and macrocyclic lactones.	Carboxylic Acids	120-136	BOC cell adhesion associated, oncogene regulated	Homo sapiens	252-255
19487247-2	2009	Unlike most UGT1A and UGT2B xenobiotic-metabolizing enzymes, UGT1A4 and UGT2B10 lack the ability to glucuronidate 4-methylumbelliferone (4MU) and 1-naphthol (1NP), both planar phenols, and naproxen (a carboxylic acid).	Carboxylic Acids	201-216	UDP glucuronosyltransferase family 2 member B10	Homo sapiens	72-79
19523823-3	2009	Previously, we reported a library of tripeptidomimics of Ornithyl-Proline (Orn-Pro) conjugated with various unnatural amino acids and carboxylic acid derived heterocyclics based on the SAR studies of existing ACE inhibitors.	Carboxylic Acids	134-149	angiotensin I converting enzyme	Homo sapiens	209-212
19514753-3	2009	It was clarified that the interaction between carbonyl/carboxylic acid groups of PLLA and the HAp nanoparticles at the CH(2)Cl(2)-water interface played a crucial role to prepare the stable Pickering-type emulsion.	Carboxylic Acids	55-70	reticulon 3	Homo sapiens	94-97
19663761-0	2009	Investigating the photostability of carboxylic acids exposed to Mars surface ultraviolet radiation conditions.	Carboxylic Acids	36-52	methionyl-tRNA synthetase 1	Homo sapiens	64-68
19557260-0	2009	A Zn-based, pillared paddlewheel MOF containing free carboxylic acids via covalent post-synthesis elaboration.	Carboxylic Acids	53-69	lysine acetyltransferase 8	Homo sapiens	33-36
19557260-1	2009	A Zn-based, mixed-ligand (pillared paddlewheel), metal-organic framework (MOF) has been covalently and quantitatively decorated with free carboxylic acids to demonstrate the utility of covalent post-synthesis modification in the construction of otherwise inaccessible carboxy-functionalized MOFs.	Carboxylic Acids	138-154	lysine acetyltransferase 8	Homo sapiens	49-78
19885010-3	2009	It is well known that aggregation of Abeta depends on its hydrophobicity, and thus, in order to increase the hydrophilicity of Abeta, we considered using citrate, an anionic surfactant with three carboxylic acid groups.	Carboxylic Acids	196-211	amyloid beta precursor protein	Homo sapiens	37-42
19156818-3	2009	Furthermore, retinoic acid binding to CRABPII mutants that lack all previously identified interacting amino acids was rescued by providing a carboxylic acid dimer partner in the form of a Glu residue.	Carboxylic Acids	141-156	cellular retinoic acid binding protein 2	Homo sapiens	38-45
19663761-4	2009	Here, we present results with regard to the impact of solar UV radiation on various carboxylic acids, such as mellitic acid, which are of astrobiological interest to the study of Mars.	Carboxylic Acids	84-100	methionyl-tRNA synthetase 1	Homo sapiens	179-183
19350541-7	2009	For instance, Tris and Ethanolamine have dpH/dT=-0.028/ degrees C and -0.029/ degrees C, respectively, whereas carboxylic acids have low dpK(a)/dT values, i.e. in the -0.002/ degrees C to+0.002/ degrees C range.	Carboxylic Acids	111-127	TAO kinase 3	Homo sapiens	137-140
19297152-2	2009	Cell 1, containing carboxylic acid groups was reacted with triethylenetetramine to introduce amine functionality to this material to obtain cell 2.	Carboxylic Acids	19-34	carboxyl ester lipase pseudogene	Homo sapiens	0-6
19297152-2	2009	Cell 1, containing carboxylic acid groups was reacted with triethylenetetramine to introduce amine functionality to this material to obtain cell 2.	Carboxylic Acids	19-34	carboxyl ester lipase pseudogene	Homo sapiens	140-146
19422229-0	2009	Discovery of potent, selective, and orally active carboxylic acid based inhibitors of matrix metalloproteinase-13.	Carboxylic Acids	50-65	matrix metallopeptidase 13	Rattus norvegicus	86-113
19422229-3	2009	Our efforts have resulted in the discovery of a series of carboxylic acid inhibitors of MMP-13 that do not significantly inhibit the related MMP-1 (collagenase-1) or tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE).	Carboxylic Acids	58-73	matrix metallopeptidase 13	Rattus norvegicus	88-94
19422229-3	2009	Our efforts have resulted in the discovery of a series of carboxylic acid inhibitors of MMP-13 that do not significantly inhibit the related MMP-1 (collagenase-1) or tumor necrosis factor-alpha (TNF-alpha) converting enzyme (TACE).	Carboxylic Acids	58-73	matrix metallopeptidase 1	Rattus norvegicus	88-93
19328685-2	2009	Novel P2-P4 macrocycle inhibitors of NS3/4A comprising a P1 C-terminal carboxylic acid have recently been disclosed.	Carboxylic Acids	71-86	KRAS proto-oncogene, GTPase	Homo sapiens	37-40
19166503-3	2009	In this study, we explore the similarities and differences in the molecular receptive ranges of four mouse odorant receptors (MOR23-1, MOR31-4, MOR32-11 and MOR40-4), which have previously been identified as receptors for aliphatic carboxylic acids.	Carboxylic Acids	232-248	olfactory receptor family 52 subfamily AB member 4	Mus musculus	126-133
19138797-1	2009	pH-responsive polymers have been synthesised by grafting l-valine (PV-75), l-leucine (PL-75) and l-phenylalanine (PP-75) onto the pendant carboxylic acid moieties of a pseudo-peptide, poly(l-lysine iso-phthalamide), at a stoichiometric degree of substitution of 75 mol%.	Carboxylic Acids	138-153	RAB11 family interacting protein 5	Homo sapiens	114-119
19166503-3	2009	In this study, we explore the similarities and differences in the molecular receptive ranges of four mouse odorant receptors (MOR23-1, MOR31-4, MOR32-11 and MOR40-4), which have previously been identified as receptors for aliphatic carboxylic acids.	Carboxylic Acids	232-248	olfactory receptor family 52 subfamily B member 4	Mus musculus	135-142
19166503-3	2009	In this study, we explore the similarities and differences in the molecular receptive ranges of four mouse odorant receptors (MOR23-1, MOR31-4, MOR32-11 and MOR40-4), which have previously been identified as receptors for aliphatic carboxylic acids.	Carboxylic Acids	232-248	olfactory receptor family 52 subfamily E member 4	Mus musculus	144-152
19166503-3	2009	In this study, we explore the similarities and differences in the molecular receptive ranges of four mouse odorant receptors (MOR23-1, MOR31-4, MOR32-11 and MOR40-4), which have previously been identified as receptors for aliphatic carboxylic acids.	Carboxylic Acids	232-248	olfactory receptor family 56 subfamily B member 2	Mus musculus	157-164
19115942-1	2009	N-(2-Mercaptopropionyl glycine)-passivated gold clusters (Au-MPG) represent a unique networked system of monolayer-protected clusters (MPCs) due to inter- and/or intramolecular hydrogen bonding between the MPC units thanks to the terminal carboxylic acid groups of the monolayers.	Carboxylic Acids	239-254	N-methylpurine DNA glycosylase	Homo sapiens	61-64
19129007-1	2009	Zinc-phthalocyanine with tyrosine substituent (ZnPcTyro) was attached to different nanocrystalline semiconductors (SnO(2) and ZnO) via carboxylic acid group, the interaction of zinc-phthalocyanine with colloidal ZnO and SnO(2) was studied by absorption and fluorescence spectroscopy.	Carboxylic Acids	135-150	strawberry notch homolog 2	Homo sapiens	115-118
19206234-4	2009	Among relatively hard acids, Fe(OTf)(3) was the best catalyst, which is also the case for ester formation from carboxylic acids and olefins.	Carboxylic Acids	111-127	POU class 5 homeobox 1	Homo sapiens	29-38
18793843-2	2009	Amidation reaction of Candida antarctica lipase B (CALB) was investigated for direct amidation of carboxylic acid in organic solvent.	Carboxylic Acids	98-113	lipase	Staphylococcus aureus	41-47
19007110-1	2008	A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist 3.	Carboxylic Acids	107-123	free fatty acid receptor 4	Homo sapiens	21-51
18781344-7	2009	However, the activity of K148A could be chemically rescued by short-chain carboxylic acids in the presence of cobalt, indicating that the carboxylated lysine was needed to coordinate the binuclear ion within the active site of hydantoinase.	Carboxylic Acids	74-90	AWN88_RS03840	Agrobacterium tumefaciens	227-239
18979283-9	2009	A correlation was shown between cell growth inhibition and the increase in INO1 expression by the carboxylic acids, factors that were reversed in the presence of inositol.	Carboxylic Acids	98-114	inositol-3-phosphate synthase INO1	Saccharomyces cerevisiae S288C	75-79
18974051-5	2008	Structure-function studies indicate that the carboxylic acid moiety, nitration at the 9 or 10 olefinic carbon, and unsaturation is required for XOR inhibition.	Carboxylic Acids	45-60	xanthine dehydrogenase	Homo sapiens	144-147
19109024-2	2009	They could be synthesized easily from various carboxylic acids 10 and commercially available amines using TFP resin without purification.	Carboxylic Acids	46-62	inhibitor of carbonic anhydrase pseudogene	Homo sapiens	106-109
19062296-1	2009	Carboxylesterases are enzymes that hydrolyze a broad suite of endogenous and exogenous ester-containing compounds to the corresponding alcohol and carboxylic acid.	Carboxylic Acids	147-162	carboxylesterase 1	Homo sapiens	0-17
19007110-1	2008	A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist 3.	Carboxylic Acids	107-123	free fatty acid receptor 4	Homo sapiens	53-59
19007110-1	2008	A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist 3.	Carboxylic Acids	107-123	peroxisome proliferator activated receptor gamma	Homo sapiens	141-189
19007110-1	2008	A weak, nonselective G protein-coupled receptor 120 (GPR120) agonist 10 was found by screening a series of carboxylic acids derived from the peroxisome proliferator-activated receptor gamma (PPARgamma) agonist 3.	Carboxylic Acids	107-123	peroxisome proliferator activated receptor gamma	Homo sapiens	191-200
18698862-1	2008	Lysozyme was immobilized on a prefabricated carboxylic acid terminated chemical template, forming a tightly packed, one monolayer thick lysozyme pattern.	Carboxylic Acids	44-59	lysozyme	Homo sapiens	0-8
18640090-0	2008	Kinetic activation of yeast mitochondrial D-lactate dehydrogenase by carboxylic acids.	Carboxylic Acids	69-85	D-lactate dehydrogenase	Saccharomyces cerevisiae S288C	42-65
18950242-1	2008	A new catalyst system, generated in situ from Cu2O, 1,10-phenanthroline, PdI2, and Tol-BINAP, for the first time allows the decarboxylative coupling of carboxylic acids with aryl triflates.	Carboxylic Acids	152-168	peptidyl arginine deiminase 2	Homo sapiens	73-77
18698862-1	2008	Lysozyme was immobilized on a prefabricated carboxylic acid terminated chemical template, forming a tightly packed, one monolayer thick lysozyme pattern.	Carboxylic Acids	44-59	lysozyme	Homo sapiens	136-144
18620381-0	2008	Novel indoline-based acyl-CoA:cholesterol acyltransferase inhibitor with antiperoxidative activity: improvement of physicochemical properties and biological activities by introduction of carboxylic acid.	Carboxylic Acids	187-202	sterol O-acyltransferase 1	Oryctolagus cuniculus	21-57
18556441-8	2008	Methylation of the carboxylic acid moiety of CBDA led to disappearance of COX-2 selectivity.	Carboxylic Acids	19-34	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	74-79
18621125-10	2008	Furthermore, the affinity of THPO and muscimol underlines the possible importance of hPAT1 as a transporter for heterocyclic compounds consisting of a 3-isoxazolol moiety, which has been shown to function as a carboxylic acid bioisostere for substrates of the GABA receptor and transport systems.	Carboxylic Acids	210-225	thrombopoietin	Homo sapiens	29-33
18621125-10	2008	Furthermore, the affinity of THPO and muscimol underlines the possible importance of hPAT1 as a transporter for heterocyclic compounds consisting of a 3-isoxazolol moiety, which has been shown to function as a carboxylic acid bioisostere for substrates of the GABA receptor and transport systems.	Carboxylic Acids	210-225	solute carrier family 36 member 1	Homo sapiens	85-90
18621125-10	2008	Furthermore, the affinity of THPO and muscimol underlines the possible importance of hPAT1 as a transporter for heterocyclic compounds consisting of a 3-isoxazolol moiety, which has been shown to function as a carboxylic acid bioisostere for substrates of the GABA receptor and transport systems.	Carboxylic Acids	210-225	GABA type A receptor-associated protein	Homo sapiens	260-273
17896760-7	2008	A high recovery ratio of CD34(+) cells was achieved at 4 degrees C in a process using 20% dextran solution through PU membranes having carboxylic acid groups.	Carboxylic Acids	135-150	CD34 molecule	Homo sapiens	25-29
18491380-4	2008	In this study, we found that only maleic acid among various carboxylic acids examined markedly induced HGF production from human dermal fibroblasts.	Carboxylic Acids	60-76	hepatocyte growth factor	Homo sapiens	103-106
18473443-5	2008	The surface carboxylic acid generated is then used to tether an osmium complex, [Os(2,2"-bipyridyl)2(4-aminomethylpyridine)Cl]PF6, to provide a covalently bound redox-active monolayer, E(0) " of 0.29 V (vs Ag/AgCl in phosphate buffer, pH 7.4), on the pretreated glassy carbon electrode.	Carboxylic Acids	12-27	sperm associated antigen 17	Homo sapiens	126-129
18513975-1	2008	A new group of hybrid nitric oxide-releasing anti-inflammatory drugs (NONO-coxibs) wherein an O(2)-acetoxymethyl-1-(N-ethyl-N-methylamino)diazen-1-ium-1,2-diolate (11a-c) NO-donor moiety is attached directly to the carboxylic acid group of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids were synthesized.	Carboxylic Acids	215-230	non-POU domain containing octamer binding	Homo sapiens	70-74
18442910-1	2008	Incorporation of a carboxylic acid into a series of uracil derivatives as hGnRH-R antagonists resulted in a significant reduction of CYP3A4 inhibitory activity.	Carboxylic Acids	19-34	gonadotropin releasing hormone receptor	Homo sapiens	74-81
18442910-1	2008	Incorporation of a carboxylic acid into a series of uracil derivatives as hGnRH-R antagonists resulted in a significant reduction of CYP3A4 inhibitory activity.	Carboxylic Acids	19-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	133-139
18492610-0	2008	Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives.	Carboxylic Acids	104-119	aldo-keto reductase family 1 member B	Homo sapiens	60-76
18381445-4	2008	Computational modeling showed the direct interaction of the carboxylic acid moiety of statins with the catalytic site of HDAC2.	Carboxylic Acids	60-75	histone deacetylase 2	Homo sapiens	121-126
18492610-1	2008	In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously synthesized carboxylic acids which we had found to be very active in vitro aldose reductase (ALR2) inhibitors.	Carboxylic Acids	63-78	aldo-keto reductase family 1 member B	Homo sapiens	224-240
18492610-1	2008	In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously synthesized carboxylic acids which we had found to be very active in vitro aldose reductase (ALR2) inhibitors.	Carboxylic Acids	63-78	aldo-keto reductase family 1 member B	Homo sapiens	242-246
18492610-1	2008	In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously synthesized carboxylic acids which we had found to be very active in vitro aldose reductase (ALR2) inhibitors.	Carboxylic Acids	161-177	aldo-keto reductase family 1 member B	Homo sapiens	224-240
18492610-1	2008	In continuation of our studies, we here report a series of non-carboxylic acid containing 2,4-thiazolidinedione derivatives, analogues of previously synthesized carboxylic acids which we had found to be very active in vitro aldose reductase (ALR2) inhibitors.	Carboxylic Acids	161-177	aldo-keto reductase family 1 member B	Homo sapiens	242-246
18404779-1	2008	The aim was to study the COX-1 inhibiting efficacy in context with hydroxyl radical scavenging properties of compounds bearing a carboxylic acid and ester function, respectively.	Carboxylic Acids	129-144	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	25-30
18230616-5	2008	Derivatization of a carboxylic acid emanating from the core ring of one of the GGTI compounds dramatically improves their cellular activity.	Carboxylic Acids	20-35	protein geranylgeranyltransferase type I subunit beta	Homo sapiens	79-83
18308567-0	2008	Carboxylic acid bioisosteres acylsulfonamides, acylsulfamides, and sulfonylureas as novel antagonists of the CXCR2 receptor.	Carboxylic Acids	0-15	C-X-C motif chemokine receptor 2	Rattus norvegicus	109-114
18308567-1	2008	A series of novel acylsulfonamide, acylsulfamide, and sulfonylurea bioisosteres of carboxylic acids were prepared as CXCR2 antagonists.	Carboxylic Acids	83-99	C-X-C motif chemokine receptor 2	Rattus norvegicus	117-122
18232705-1	2008	A methodology for the enantioselective synthesis of alpha-fluorinated beta2-amino acids has been developed from readily available carboxylic acids 3.	Carboxylic Acids	130-146	potassium calcium-activated channel subfamily M regulatory beta subunit 2	Homo sapiens	70-75
18322911-4	2008	It was found that addition of PAA to the mineral solution and use of matrix with carboxylic acid groups promoted mineral growth and distribution of HAp.	Carboxylic Acids	81-96	retinoic acid receptor, beta	Mus musculus	148-151
18023179-0	2008	Carboxylic acid based quinolines as liver X receptor modulators that have LXRbeta receptor binding selectivity.	Carboxylic Acids	0-15	nuclear receptor subfamily 1 group H member 2	Homo sapiens	74-81
18175010-0	2008	Slow proton transfer from the hydrogen-labelled carboxylic acid side chain (Glu-165) of triosephosphate isomerase to imidazole buffer in D2O.	Carboxylic Acids	48-63	triosephosphate isomerase 1	Homo sapiens	88-113
17920042-2	2008	However, we previously found that the predominant biotransformation route for the hepatocarcinogen 1-hydroxymethylpyrene (1-HMP) in the rat in vivo is the oxidation of the side chain by alcohol dehydrogenases (ADHs) and aldehyde dehydrogenases to the carboxylic acid.	Carboxylic Acids	251-266	inner membrane mitochondrial protein	Homo sapiens	124-127
19006146-0	2008	DCC-Assisted esterification of a polyoxometalate-functionalized phenol with carboxylic acids (DCC: dicyclohexylcarbodiimide).	Carboxylic Acids	76-92	DCC netrin 1 receptor	Homo sapiens	0-3
19006146-0	2008	DCC-Assisted esterification of a polyoxometalate-functionalized phenol with carboxylic acids (DCC: dicyclohexylcarbodiimide).	Carboxylic Acids	76-92	DCC netrin 1 receptor	Homo sapiens	94-97
18445991-1	2008	Losartan, a selective angiotensin receptor antagonist, is mainly metabolized by CYP2C9 to an active carboxylic acid, E3174, which is pharmacologically more potent inhibitor than the parent compound.	Carboxylic Acids	100-115	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	80-86
18045085-1	2007	A macrocyclic calix[6]arene carboxylic acid derivative is found to extract lysine-rich protein cytochrome c from aqueous media into organic media through the complexation between the calixarene molecules and lysine residues on the surface of the protein.	Carboxylic Acids	28-43	cytochrome c, somatic	Homo sapiens	95-107
17932246-6	2008	We developed a novel nonbrain-permeable MCH antagonist analog with a carboxylic acid moiety to specifically test the site of action.	Carboxylic Acids	69-84	modifier of chinchilla	Mus musculus	40-43
17956868-7	2007	In this report we also identified a single active site residue important for glucuronidation of phenols and carboxylic acid substrates by UGT1A enzyme family.	Carboxylic Acids	108-123	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	138-143
17973530-1	2007	A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh3, CCl4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields.	Carboxylic Acids	63-79	protein phosphatase 4 catalytic subunit	Homo sapiens	99-103
17973530-1	2007	A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh3, CCl4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields.	Carboxylic Acids	63-79	C-C motif chemokine ligand 4	Homo sapiens	105-109
17973530-1	2007	A unique one-pot cyclization of 2-aminophenethyl alcohols with carboxylic acids in the presence of PPh3, CCl4, and NEt3 furnished the formation of N-acyl indolines in good to excellent yields.	Carboxylic Acids	63-79	tetraspanin 2	Homo sapiens	115-119
17458696-0	2007	Truncations and functional carboxylic acid residues of yeast processing alpha-glucosidase I. Yeast alpha-glucosidase I (Cwh41p) encoded by CWH41 is an endoplasmic reticulum (ER) membrane-bound glycoprotein (833 residues), which plays an important role in the early steps of the N-glycosylation pathway.	Carboxylic Acids	27-42	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	120-126
17920610-4	2007	OASIS HLB sorbent material (Waters) was used to extract and enrich polar carboxylic acids from aqueous solutions with recoveries greater than 80% for most analytes.	Carboxylic Acids	73-89	cAMP responsive element binding protein 3 like 1	Homo sapiens	0-5
17458696-0	2007	Truncations and functional carboxylic acid residues of yeast processing alpha-glucosidase I. Yeast alpha-glucosidase I (Cwh41p) encoded by CWH41 is an endoplasmic reticulum (ER) membrane-bound glycoprotein (833 residues), which plays an important role in the early steps of the N-glycosylation pathway.	Carboxylic Acids	27-42	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	139-144
17458696-6	2007	In addition, two highly conserved carboxylic acid residues, E580 and D584 of Cwht1p (corresponding to E613 and D617 of Cwh41p), located within the catalytic domain of yeast enzyme were subjected to mutation.	Carboxylic Acids	34-49	mannosyl-oligosaccharide glucosidase	Saccharomyces cerevisiae S288C	119-125
17766451-4	2007	Pad1p is therefore an unusual decarboxylase capable of accepting both aromatic and aliphatic carboxylic acids as substrates.	Carboxylic Acids	93-109	phenylacrylic acid decarboxylase PAD1	Saccharomyces cerevisiae S288C	0-5
17482256-3	2007	In the preparation of a monolayer, triethylene glycol-terminated alkanethiol was mixed with carboxylic acid-terminated alkanethiol at various compositions in order to reduce the non-specific adsorption of EGF.	Carboxylic Acids	92-107	epidermal growth factor like 1	Rattus norvegicus	205-208
17597201-4	2007	The carboxylated CarboSil can then be used to immobilize TM through the formation of an amide bond between the surface carboxylic acid groups and the lysine residues of TM.	Carboxylic Acids	119-134	thrombomodulin	Homo sapiens	57-59
17597201-4	2007	The carboxylated CarboSil can then be used to immobilize TM through the formation of an amide bond between the surface carboxylic acid groups and the lysine residues of TM.	Carboxylic Acids	119-134	thrombomodulin	Homo sapiens	169-171
17597201-5	2007	Aminated CarboSil can also be employed to initially couple heparin to the surface, and then the carboxylic acid groups on heparin can be further used to anchor TM.	Carboxylic Acids	96-111	thrombomodulin	Homo sapiens	160-162
17663527-6	2007	The spacer groups (X), the monodentate isocyanide units, and a tetradentate NS3 chelator bearing a pendant carboxylic acid (NS3COOH) were proposed as pharmacological modifiers.	Carboxylic Acids	107-122	KRAS proto-oncogene, GTPase	Homo sapiens	76-79
17572060-0	2007	Analysis of structure-cytotoxicity in vitro relationship (SAR) for perfluorinated carboxylic acids.	Carboxylic Acids	82-98	sarcosine dehydrogenase	Homo sapiens	58-61
17676806-1	2007	Optimization of the kinetic resolution of 2-amino-4-phenyl-butane was achieved at 80 degrees C using CAL-B-catalyzed aminolysis of carboxylic acids and their ethyl esters.	Carboxylic Acids	131-147	calbindin 1	Homo sapiens	101-106
17449253-0	2007	Evaluation of a diverse set of potential P1 carboxylic acid bioisosteres in hepatitis C virus NS3 protease inhibitors.	Carboxylic Acids	44-59	KRAS proto-oncogene, GTPase	Homo sapiens	94-97
17591750-2	2007	Adsorption of the LH1-RC complexes on the SAMs depended on the terminating group of the alkanethiols, where the adsoption increased in the following order for the terminating groups: amino groups > carboxylic acid groups > methyl groups.	Carboxylic Acids	201-216	procollagen-lysine,2-oxoglutarate 5-dioxygenase 1	Homo sapiens	18-21
17404764-1	2007	The gas phase Gibbs free energies deltaG(T) of dissociation reaction of 14 carboxylic acids were calculated on the SCF, as well as G3 and CBS-Q levels.	Carboxylic Acids	75-91	KIT ligand	Homo sapiens	115-118
17579775-5	2007	Structural features of MJE3 important for PGAM1 labeling included two key recognition elements (an indole ring and carboxylic acid), the stereochemical orientation of the spiroepoxide, and presentation of these various binding/reactive groups on a rigid cyclohexane scaffold.	Carboxylic Acids	115-130	phosphoglycerate mutase 1	Homo sapiens	42-47
17533125-1	2007	PPARgamma-activating thiazolidinediones and carboxylic acids such as farglitazar exert their anti-diabetic effects in part in PPARgamma rich adipose.	Carboxylic Acids	44-60	peroxisome proliferator activated receptor gamma	Homo sapiens	126-135
17449253-3	2007	Product-based NS3 protease inhibitors comprising a P1 C-terminal carboxylic acid have shown to be effective and we were interested in finding alternatives to this crucial carboxylic acid group.	Carboxylic Acids	65-80	KRAS proto-oncogene, GTPase	Homo sapiens	14-17
17449253-4	2007	Thus, a series of diverse P1 functional groups with different acidity and with possibilities to form a similar, or an even more powerful, hydrogen bond network as compared to the carboxylic acid were synthesized and incorporated into potential inhibitors of the NS3 protease.	Carboxylic Acids	179-194	KRAS proto-oncogene, GTPase	Homo sapiens	262-265
17449253-9	2007	Additionally, results from a pH-study suggest that the P(1) C-terminal of the inhibitors comprising a carboxylic acid, an acyl sulfonamide or an acyl cyanamide group binds in a similar mode in the active site of the NS3 protease.	Carboxylic Acids	102-117	KRAS proto-oncogene, GTPase	Homo sapiens	216-219
17516991-7	2007	Losartan and E3174, the CYP2C9-derived carboxylic acid metabolite of losartan in 8 hr urine were assayed by using high pressure liquid chromatography.	Carboxylic Acids	39-54	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	24-30
17500511-1	2007	High-throughput screening of a subset of the J&J compound library containing the carboxylic acid functional group uncovered a bromophenyl derivative as a moderate potent GPR40 agonist.	Carboxylic Acids	85-100	free fatty acid receptor 1	Mus musculus	174-179
17509630-9	2007	The spatial orientation of the carboxylic acid of the side chain is referred to two almost perpendicular planes (defined by (1) the carbon atoms C1/C6-C17/C20 and by (2) the methyl groups C18-C19 and the two carbon atoms to which they are linked, C10 and C13, respectively).	Carboxylic Acids	31-46	Bardet-Biedl syndrome 9	Homo sapiens	188-191
17509630-9	2007	The spatial orientation of the carboxylic acid of the side chain is referred to two almost perpendicular planes (defined by (1) the carbon atoms C1/C6-C17/C20 and by (2) the methyl groups C18-C19 and the two carbon atoms to which they are linked, C10 and C13, respectively).	Carboxylic Acids	31-46	homeobox C10	Homo sapiens	247-250
17509630-9	2007	The spatial orientation of the carboxylic acid of the side chain is referred to two almost perpendicular planes (defined by (1) the carbon atoms C1/C6-C17/C20 and by (2) the methyl groups C18-C19 and the two carbon atoms to which they are linked, C10 and C13, respectively).	Carboxylic Acids	31-46	homeobox C13	Homo sapiens	255-258
17371021-1	2007	We present a novel series of hydrogen-bonded, polycrystalline 1:1 complexes of Schiff base models of the cofactor pyridoxal-5"-phosphate (PLP) with carboxylic acids that mimic the cofactor in a variety of enzyme active sites.	Carboxylic Acids	148-164	pyridoxal phosphatase	Homo sapiens	138-141
17425347-3	2007	Our XPS results showed that the surface reaction between OTS-SAMs and oxygen plasma can generate new surface functional groups such as alcohol (C-O), aldehyde (C=O), and carboxylic acid (O-C=O), and their compositions can be controlled by using different treatment times and powers.	Carboxylic Acids	170-185	methionine adenosyltransferase 1A	Homo sapiens	61-65
17373851-3	2007	The polymer-bound monoacylglycerol 5, formed in this manner, is transformed to the respective polymer-bound diacylglycerols 7 and 9 by reaction of the free alcohol moiety with a second carboxylic acid under conditions that lead to retention or inversion of C-2 stereochemistry.	Carboxylic Acids	185-200	complement C2	Homo sapiens	257-260
17485826-4	2007	This conversion was found to be an efficient method for the preparation of carboxylic acids (Cn) to one-carbon degraded aldehydes (Cn-1) via 2-hydroperoxy acids.	Carboxylic Acids	75-91	5'-nucleotidase, cytosolic IA	Homo sapiens	131-135
17388359-2	2007	PFALs can be further oxidized in the gas phase to give perfluorinated carboxylic acids (PFCAs, CnF2n+1C(O)OH, n = 6, 12) which have been detected in animal tissues and at low parts per billion levels in human blood sera.	Carboxylic Acids	70-86	NPHS1 adhesion molecule, nephrin	Homo sapiens	95-98
17335217-0	2007	Palladium-catalyzed methylation and arylation of sp2 and sp3 C-H bonds in simple carboxylic acids.	Carboxylic Acids	81-97	Sp2 transcription factor	Homo sapiens	49-52
17320401-2	2007	In continuation of our attempts to develop novel cPLA(2)alpha inhibitors, a number of derivatives of these substances characterized by bioisosteric replacement of the carboxylic acid and carboxamide functionality, respectively, were prepared.	Carboxylic Acids	167-182	phospholipase A2 group IVA	Homo sapiens	49-61
17319704-1	2007	The redox properties of horse and yeast cytochrome c electrostatically immobilized on carboxylic acid-terminated self-assembled monolayers (SAMs) have been determined over a broad pH range (pH 3.5-8) in the absence and presence of nitric oxide.	Carboxylic Acids	86-101	cytochrome c, somatic	Equus caballus	40-52
17335217-0	2007	Palladium-catalyzed methylation and arylation of sp2 and sp3 C-H bonds in simple carboxylic acids.	Carboxylic Acids	81-97	Sp3 transcription factor	Homo sapiens	57-60
17240142-1	2007	The discovery, synthesis and structure-activity relationship (SAR) of novel carboxylic acid agonists for GPR40 are described.	Carboxylic Acids	76-91	free fatty acid receptor 1	Rattus norvegicus	105-110
17936933-1	2007	Carboxylesterases (CEs) are traditionally regarded as xenobiotic metabolizing enzymes that hydrolyze esterified xenobiotics to alcohol and carboxylic acid products.	Carboxylic Acids	139-154	carboxylesterase 1	Homo sapiens	0-17
17228871-5	2007	The introduction of a functional group at the side chain of C-11 modified the potency; carboxylic acid and primary amine decreased the cytotoxicity, whereas a cyano group increased the activity.	Carboxylic Acids	87-102	RNA polymerase III subunit K	Homo sapiens	60-64
17854102-6	2007	The hydration number determined for TbL3 decreases with increasing pH value and becomes fractional at pH 7.5, which points to an equilibrium between two differently solvated species and probably to the participation of the deprotonated carboxylic acid chain in the complexation.	Carboxylic Acids	236-251	transducin beta like 3	Homo sapiens	36-40
18417764-2	2007	Six main classes of reaction are observed corresponding to: two competing carboxylate abstraction pathways (from the sn1 and sn2 positions); phosphate abstraction; competing losses of the two different carboxylic acids from the sn1 and sn2 positions; loss of a protonated ligand, [L + H](+).	Carboxylic Acids	202-218	solute carrier family 38 member 3	Homo sapiens	228-231
18417764-2	2007	Six main classes of reaction are observed corresponding to: two competing carboxylate abstraction pathways (from the sn1 and sn2 positions); phosphate abstraction; competing losses of the two different carboxylic acids from the sn1 and sn2 positions; loss of a protonated ligand, [L + H](+).	Carboxylic Acids	202-218	solute carrier family 38 member 5	Homo sapiens	236-239
17197187-2	2007	The functionalities considered at C-9 were carboxylic acids and several derivatives such as esters, amides, nitriles or anhydrides.	Carboxylic Acids	43-59	complement C9	Homo sapiens	34-37
17112638-1	2007	A 30-membered library of amides based on the potent urotensin II (UII) receptor agonist FL104, has been synthesized from ten different carboxylic acids and three amines.	Carboxylic Acids	135-151	urotensin 2 receptor	Homo sapiens	52-79
17227023-5	2007	In-plane force titrations were found to have the sensitivity to detect ionic hydrogen bond formation between protonated and nonprotonated carboxylic acid groups in the proximity of the surface pK1/2, which generated a mean tensile differential surface stress of +1.2 +/- 0.3 mN/m at pH 6.0, corresponding to 1 pN attractive force between two adjacent MHA molecules.	Carboxylic Acids	138-153	prokineticin 1	Homo sapiens	193-198
16902417-7	2007	Only carboxylic acid-coated QDs significantly increased release of IL-1beta, IL-6, and IL-8.	Carboxylic Acids	5-20	interleukin 1 beta	Homo sapiens	67-75
16902417-7	2007	Only carboxylic acid-coated QDs significantly increased release of IL-1beta, IL-6, and IL-8.	Carboxylic Acids	5-20	interleukin 6	Homo sapiens	77-81
16902417-7	2007	Only carboxylic acid-coated QDs significantly increased release of IL-1beta, IL-6, and IL-8.	Carboxylic Acids	5-20	C-X-C motif chemokine ligand 8	Homo sapiens	87-91
16563728-4	2006	N-NCD was coated on gold electrode and glucose oxidase (GOx) was immobilized onto the surfaces of N-NCD by forming amide linkages between enzyme amine residues and carboxylic acid groups on N-NCD.	Carboxylic Acids	164-179	hydroxyacid oxidase 1	Homo sapiens	39-54
16563728-4	2006	N-NCD was coated on gold electrode and glucose oxidase (GOx) was immobilized onto the surfaces of N-NCD by forming amide linkages between enzyme amine residues and carboxylic acid groups on N-NCD.	Carboxylic Acids	164-179	hydroxyacid oxidase 1	Homo sapiens	56-59
16879970-0	2006	Further optimization of sulfonamide analogs as EP1 receptor antagonists: synthesis and evaluation of bioisosteres for the carboxylic acid group.	Carboxylic Acids	122-137	prostaglandin E receptor 1	Homo sapiens	47-50
16879970-2	2006	Compound 2b and its monocyclic acid analogs, in which the carboxylic acid residue of 2b was replaced with monocyclic acid bioisosteres, were found to show potent EP1 receptor antagonist activity.	Carboxylic Acids	58-73	prostaglandin E receptor 1	Homo sapiens	162-165
16443618-5	2006	Fibronectin is immobilized onto the hydrolyzed PLA surface through a condensation reaction between the carboxylic acid groups on the hydrolyzed PLA surface and the amino groups of fibronectin using water-soluble carbodiimide.	Carboxylic Acids	103-118	fibronectin 1	Homo sapiens	0-11
17003340-1	2006	Previously studied inhibitors of aldose reductase were largely from two chemical classes, spirosuccinamide/hydantoins and carboxylic acids.	Carboxylic Acids	122-138	aldo-keto reductase family 1 member B	Homo sapiens	33-49
16903719-4	2006	Complex 1a readily reacted with carboxylic acids to afford the tetranuclear copper(II) complexes, [Cu4{mu-(alpha-D-Glc-1P)}2(mu-CA)2(bpy)4](NO3)2 [CA = CH3COO (3), o-C6H4(COO)(COOH) (4)].	Carboxylic Acids	32-48	GLC1P	Homo sapiens	115-121
16757166-1	2006	Recently, we reported potent and small-sized beta-secretase (BACE1) inhibitors KMI-570 and KMI-684 in which we replaced carboxylic acid groups at the P(1)(") position of KMI-420 and KMI-429, respectively, with tetrazole derivatives as carboxylic acid bioisosteres.	Carboxylic Acids	120-135	beta-secretase 1	Homo sapiens	61-66
16757166-1	2006	Recently, we reported potent and small-sized beta-secretase (BACE1) inhibitors KMI-570 and KMI-684 in which we replaced carboxylic acid groups at the P(1)(") position of KMI-420 and KMI-429, respectively, with tetrazole derivatives as carboxylic acid bioisosteres.	Carboxylic Acids	235-250	beta-secretase 1	Homo sapiens	61-66
16453309-2	2006	In the photoreceptor rhodopsin, and possibly other rhodopsin-like GPCRs, protonation of a carboxylic acid in the conserved E(D)RY motif at the cytosolic end of transmembrane helix 3 (TM3) is coupled to receptor activation.	Carboxylic Acids	90-105	rhodopsin	Homo sapiens	21-30
16453309-2	2006	In the photoreceptor rhodopsin, and possibly other rhodopsin-like GPCRs, protonation of a carboxylic acid in the conserved E(D)RY motif at the cytosolic end of transmembrane helix 3 (TM3) is coupled to receptor activation.	Carboxylic Acids	90-105	rhodopsin	Homo sapiens	51-60
16632358-1	2006	A series of novel carboxylic acid-based alpha-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed.	Carboxylic Acids	18-33	matrix metallopeptidase 1	Homo sapiens	54-57
16632358-1	2006	A series of novel carboxylic acid-based alpha-sulfone MMP inhibitors have been synthesized and the in vitro enzyme SAR is discussed.	Carboxylic Acids	18-33	sarcosine dehydrogenase	Homo sapiens	115-118
16318858-7	2006	Of the other carboxylic acids studied, the short chain acids, C3-C5, without branching were the best inhibitors of histone deacetylase.	Carboxylic Acids	13-29	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	62-67
16732655-9	2006	The aggregation mechanism is, therefore, believed to be due to hydrogen-bonding between the hydrogens of the carboxylic acid groups and the ether oxygens present on the surface of the PEO-functionalized particles.	Carboxylic Acids	109-124	twinkle mtDNA helicase	Homo sapiens	184-187
16481167-3	2006	Herein, we report BACE1 inhibitors with P1" carboxylic acid bioisosteres in order to develop practical anti-Alzheimer"s disease drugs.	Carboxylic Acids	44-59	beta-secretase 1	Homo sapiens	18-23
16599619-1	2006	An efficient, transition-metal-free procedure for the N-arylation of amines, sulfonamides, and carbamates and O-arylation of phenols and carboxylic acids has been achieved by allowing these substrates to react with a variety of o-silylaryl triflates in the presence of CsF.	Carboxylic Acids	137-153	colony stimulating factor 2	Homo sapiens	269-272
16546182-4	2006	Here, using site-directed mutagenesis and fluorescent probe displacements, we show that Lys112 is the major determinant for governing hOBP-2A specificity towards aldehydes and small carboxylic acids.	Carboxylic Acids	182-198	odorant binding protein 2A	Homo sapiens	134-141
16190722-4	2005	Titration of the support materials showed the presence of 0.17 and 0.03 mmol/g carboxylic acid groups for CNF-O and CNF-OR, respectively.	Carboxylic Acids	79-94	NPHS1 adhesion molecule, nephrin	Homo sapiens	106-109
16263300-0	2006	New substrates and inhibitors of gamma-aminobutyric acid aminotransferase containing bioisosteres of the carboxylic acid group: design, synthesis, and biological activity.	Carboxylic Acids	105-120	4-aminobutyrate aminotransferase	Homo sapiens	33-73
16263300-1	2006	A series of potential substrates of gamma-aminobutyric acid aminotransferase (GABA-AT) with lipophilic bioisosteres of the carboxylic acid group (2-7) were synthesized and tested.	Carboxylic Acids	123-138	4-aminobutyrate aminotransferase	Homo sapiens	36-76
16263300-1	2006	A series of potential substrates of gamma-aminobutyric acid aminotransferase (GABA-AT) with lipophilic bioisosteres of the carboxylic acid group (2-7) were synthesized and tested.	Carboxylic Acids	123-138	4-aminobutyrate aminotransferase	Homo sapiens	78-85
16787354-5	2006	While most of the carboxylic acids ALR2 inhibitors are acetic acid derivatives, in the case of thienocinnolinone compounds, homologues higher than acetic acids showed to be more active.	Carboxylic Acids	18-34	lens aldose reductase pseudogene	Bos taurus	35-39
16213143-0	2006	Exploration of acyl sulfonamides as carboxylic acid replacements in protease inhibitors of the hepatitis C virus full-length NS3.	Carboxylic Acids	36-51	KRAS proto-oncogene, GTPase	Homo sapiens	125-128
16471557-2	2006	We consider the, so-called, carboxylic acid end-standing P85 (CAE-85) case where the carboxylic group is located at the end of both PEO parts and the carboxylic acid center-standing P85 (CAC-85) case where each of the carboxylic group presents between the PEO and PPO blocks.	Carboxylic Acids	28-43	protoporphyrinogen oxidase	Homo sapiens	264-267
16169736-1	2005	Previous studies from our laboratory have revealed that esterification/amidation of the carboxylic acid moiety in the nonsteroidal anti-inflammatory drug, indomethacin, generates potent and selective COX-2 inhibitors.	Carboxylic Acids	88-103	cytochrome c oxidase II, mitochondrial	Mus musculus	200-205
15812642-0	2005	Characterization of Sphingomonas aldehyde dehydrogenase catalyzing the conversion of various aromatic aldehydes to their carboxylic acids.	Carboxylic Acids	121-137	Aldehyde dehydrogenase	Escherichia coli	33-55
16190759-0	2005	A novel series of non-carboxylic acid, non-hydantoin inhibitors of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran-2-sulfonyl)-2H-pyridazin-3-one and congeners.	Carboxylic Acids	22-37	aldo-keto reductase family 1 member B1	Rattus norvegicus	67-83
16190759-1	2005	Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a long-standing challenge.	Carboxylic Acids	54-69	aldo-keto reductase family 1 member B1	Rattus norvegicus	98-114
16190759-1	2005	Discovery of a highly selective, potent, and safe non-carboxylic acid, non-hydantoin inhibitor of aldose reductase (AR) capable of potently blocking the excess glucose flux through the polyol pathway that prevails under diabetic conditions has been a long-standing challenge.	Carboxylic Acids	54-69	aldo-keto reductase family 1 member B1	Rattus norvegicus	116-118
16190722-4	2005	Titration of the support materials showed the presence of 0.17 and 0.03 mmol/g carboxylic acid groups for CNF-O and CNF-OR, respectively.	Carboxylic Acids	79-94	NPHS1 adhesion molecule, nephrin	Homo sapiens	116-119
16105239-6	2005	These results suggest that MCT1 contributes at least in part to the carrier-mediated transport of NSAIDs containing a carboxylic acid moiety across the apical membrane in Caco-2 cells.	Carboxylic Acids	118-133	solute carrier family 16 member 1	Homo sapiens	27-31
16032359-3	2005	The decarboxylated products and the intermediate 2-pyridones in the form of carboxylic acid methyl esters and carboxylic acids were screened for their effect on Abeta-peptide aggregation.	Carboxylic Acids	110-126	amyloid beta precursor protein	Homo sapiens	161-166
15792492-7	2005	It is proposed that [CuL]+ most likely features I coordinated via the deprotonated carboxylic acid group (O1) and the endocyclic oxygen atom (OR) forming a five-membered chelate ring.	Carboxylic Acids	83-98	cullin 2	Homo sapiens	21-24
15798002-9	2005	We conclude that CUDA and AUDA, by virtue of their carboxylic acid substitution, activate PPARalpha in addition to potently inhibiting sEH.	Carboxylic Acids	51-66	peroxisome proliferator activated receptor alpha	Homo sapiens	90-99
15799868-7	2005	In vitro zymography and enzyme assays showed for both hydroxamic acid and carboxylic acid compounds a good inhibition activity and a high selectivity for MMP-2.	Carboxylic Acids	74-89	matrix metallopeptidase 2	Mus musculus	154-159
15962356-3	2005	In contrast, compounds with different acyloxy groups at C-8 fragment by means of elimination of the corresponding carboxylic acids [M + H - (R(2)CO(2)H)](+) and consecutive losses of CO and H(2)O.	Carboxylic Acids	114-130	homeobox C8	Homo sapiens	56-59
15797139-2	2005	The lactonization could result from the C-2 carboxylic acid of the nonreducing residue condensing with the hydroxyl group or/and sulfated group at C-9 of the reducing residue to form a six-membered ring between two adjacent sialic acid residues.	Carboxylic Acids	44-59	complement C9	Homo sapiens	147-150
15849423-3	2005	We investigated the substrate specificities of firefly luciferase and CG6178 as an acyl-CoA synthetase utilizing a series of carboxylic acids.	Carboxylic Acids	125-141	uncharacterized protein	Drosophila melanogaster	70-76
15715496-2	2005	We reasoned that antithrombin activation should be possible with nonsulfated activators based only on carboxylic acid groups.	Carboxylic Acids	102-117	serpin family C member 1	Homo sapiens	17-29
15727850-3	2005	Unexpectedly, replacement of the carboxylic acid required for brequinar to inhibit hDHODH was not essential in the diisopropylamides that inhibited PfDHODH.	Carboxylic Acids	33-48	dihydroorotate dehydrogenase (quinone)	Homo sapiens	83-89
16097692-6	2005	When pH>4, the fluorescence emission peak at 499 nm gradually blue-shifted to 455 nm as pH was increasing, and an iso-fluorescence emission point was formed at 484 nm, indicating the dissociation of hydrogen ion of carboxylic acid at C-3.	Carboxylic Acids	218-233	complement C3	Homo sapiens	237-240
15686897-2	2005	Installation of a furan carboxylic acid fragment onto a low-micromolar sulfamide resulted in a 23-fold improvement in activity, providing a sub-micromolar, nonpeptidic IL-2 inhibitor (IC(50)=0.60 microM).	Carboxylic Acids	24-39	interleukin 2	Homo sapiens	168-172
15581900-1	2005	Drosophila alcohol dehydrogenase (DADH) is an NAD+-dependent enzyme that catalyzes the oxidation of alcohols to aldehydes/ketones and that is also able to further oxidize aldehydes to their corresponding carboxylic acids.	Carboxylic Acids	204-220	Alcohol dehydrogenase	Drosophila melanogaster	0-32
15684518-5	2005	In particular, 90 having a carboxylic acid functionality at the 7-position of the indole nucleus showed the most potent human beta3-AR agonistic activity.	Carboxylic Acids	27-42	adrenoceptor beta 3	Homo sapiens	126-134
15581900-1	2005	Drosophila alcohol dehydrogenase (DADH) is an NAD+-dependent enzyme that catalyzes the oxidation of alcohols to aldehydes/ketones and that is also able to further oxidize aldehydes to their corresponding carboxylic acids.	Carboxylic Acids	204-220	Alcohol dehydrogenase	Drosophila melanogaster	34-38
15598553-3	2005	Several carboxylic acid-based compounds were tested and shown to inhibit XR.	Carboxylic Acids	8-23	dicarbonyl and L-xylulose reductase	Homo sapiens	73-75
15578836-7	2004	Moreover the X-ray structure of rac-2 was also determined and exhibits as an outstanding feature the formation of a one-dimensional supramolecular species in which the cohesion of the system is maintained by strong hydrogen bonding between carboxylic acid groups of enantiomers Delta-2 and Lambda-2 (cationic parts) with d(O...O) = 2.6 A in agreement with the infrared results.	Carboxylic Acids	240-255	Rac family small GTPase 2	Homo sapiens	32-37
15609952-4	2004	In this work, we show that Delta H(o)(acid)(HX), EA(X(*)), and BDE(HX) are all linearly related for specific classes of compounds (e.g., alcohols and carboxylic acids), and therefore, only one of these quantities is needed to determine the others.	Carboxylic Acids	150-166	homeobox D13	Homo sapiens	63-66
15535725-1	2004	The photophysical and luminescence quenching properties of a platinum(II) acetylide-based conjugated polyelectrolyte, Pt-p, which features carboxylic acid solubilizing groups are reported.	Carboxylic Acids	139-154	regenerating family member 1 alpha	Homo sapiens	118-122
15623333-2	2004	By monitoring the solution pH change associated with metal uptake, it is concluded that Mg(II), Ca(II) and Zn(II) bind to carboxylic acid groups in melanin, Cu(II) binds to hydroxyl (OH) groups and Fe(III) binds to OH or amine groups.	Carboxylic Acids	122-137	carbonic anhydrase 2	Homo sapiens	96-102
15527800-2	2004	Fluorescence titrations show that the affinity of complex formation of Ca4.CaM with the key 21-residue target peptide increases 1000-fold from pH 9.0 to 4.8, suggesting the involvement of histidine and carboxylic acid residues.	Carboxylic Acids	202-217	calmodulin 1	Homo sapiens	75-78
15454216-2	2004	Introduction of a side chain with a carboxylic acid at the terminal position to 1 resulted in increased ability to inhibit human renal microsomal production of 20-HETE (7c: IC(50) 7.9nM), with good selectivity toward CYP2D6 and cyclooxygenases (COX)-1 and -2.	Carboxylic Acids	36-51	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	217-223
15454216-2	2004	Introduction of a side chain with a carboxylic acid at the terminal position to 1 resulted in increased ability to inhibit human renal microsomal production of 20-HETE (7c: IC(50) 7.9nM), with good selectivity toward CYP2D6 and cyclooxygenases (COX)-1 and -2.	Carboxylic Acids	36-51	prostaglandin-endoperoxide synthase 1	Homo sapiens	228-258
15287721-9	2004	One or more carboxylic acid residues in Eg5 undergo unique changes when ATP, but not ADP, interacts with the motor domain in the presence of monastrol.	Carboxylic Acids	12-27	kinesin family member 11	Homo sapiens	40-43
15646024-1	2004	BACKGROUND/AIMS: Retinoic acid (RA), the carboxylic acid form of vitamin A, through the activation of cognate receptors, stimulates the transcription of the gene encoding uncoupling protein 1 (UCP1), which is critical to brown adipose tissue (BAT) thermogenesis.	Carboxylic Acids	41-56	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	171-191
15646024-1	2004	BACKGROUND/AIMS: Retinoic acid (RA), the carboxylic acid form of vitamin A, through the activation of cognate receptors, stimulates the transcription of the gene encoding uncoupling protein 1 (UCP1), which is critical to brown adipose tissue (BAT) thermogenesis.	Carboxylic Acids	41-56	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	193-197
15323522-0	2004	Preparation and nanoscale mechanical properties of self-assembled carboxylic acid functionalized pentathiophene on mica.	Carboxylic Acids	66-81	MHC class I polypeptide-related sequence A	Homo sapiens	115-119
14607257-7	2003	Here, we briefly summarize the recent identification of neuropeptides W and B and carboxylic acid anions for their respective receptors GPR7, GPR8 and GPR40, GPR41, GPR43.	Carboxylic Acids	82-97	neuropeptides B and W receptor 1	Homo sapiens	136-140
15237983-1	2004	An alpha,alpha-dimethyl-3,5-dimethoxybenzyloxycarbonyl (DDZ)-protected amine monolayer can be selectively deprotected by the application of a voltage bias from a conducting AFM tip to afford localized nanoscale patterns that can be visualized by self-assembly of dendritic molecular objects with terminal carboxylic acid groups and different aspect ratios.	Carboxylic Acids	305-320	TOR signaling pathway regulator	Homo sapiens	177-180
15140071-7	2004	The pH-dependent binding of Mg(II) and Ca(II) suggests coordination of these ions to carboxylic acid groups in the pigment.	Carboxylic Acids	85-100	carbonic anhydrase 2	Homo sapiens	39-45
15468216-2	2004	PHB macromonomers were prepared from the esterification of oligomers with 2-hydroxyethyl methacrylate at their carboxylic acid end.	Carboxylic Acids	111-126	prohibitin 1	Homo sapiens	0-3
14719942-0	2004	In situ FTIR-ATR analysis and titration of carboxylic acid-terminated SAMs.	Carboxylic Acids	43-58	methionine adenosyltransferase 1A	Homo sapiens	70-74
15158806-4	2004	We propose that stampidine undergoes rapid enzymatic hydrolysis in the presence of lipase according to the following biochemical pathway: During the first step, hydrolysis of the ester group results in the formation of carboxylic acid.	Carboxylic Acids	219-234	PAN0_003d1715	Moesziomyces antarcticus	83-89
15115394-6	2004	The vinyl-ACCA is the first reported carboxylic acid containing a P1 residue that produced NS3 protease inhibitors that are significantly more active than inhibitors containing a cysteine at the same position.	Carboxylic Acids	37-52	KRAS proto-oncogene, GTPase	Homo sapiens	91-94
15047194-3	2004	In this study, recombinant expressed UGT isoforms were investigated with many structurally related carboxylic acid analogues, and the UGT rank order for catalyzing the glucuronidation of carboxylic acids was UGT2B7?UGT1A3 approximately UGT1A9.	Carboxylic Acids	187-203	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	208-214
15047194-3	2004	In this study, recombinant expressed UGT isoforms were investigated with many structurally related carboxylic acid analogues, and the UGT rank order for catalyzing the glucuronidation of carboxylic acids was UGT2B7?UGT1A3 approximately UGT1A9.	Carboxylic Acids	187-203	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	215-221
15047194-3	2004	In this study, recombinant expressed UGT isoforms were investigated with many structurally related carboxylic acid analogues, and the UGT rank order for catalyzing the glucuronidation of carboxylic acids was UGT2B7?UGT1A3 approximately UGT1A9.	Carboxylic Acids	187-203	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	236-242
14729911-3	2004	Positional cloning of the REF1 gene revealed that it encodes an aldehyde dehydrogenase, a member of a large class of NADP(+)-dependent enzymes that catalyze the oxidation of aldehydes to their corresponding carboxylic acids.	Carboxylic Acids	207-223	aldehyde dehydrogenase 2C4	Arabidopsis thaliana	26-30
14607257-7	2003	Here, we briefly summarize the recent identification of neuropeptides W and B and carboxylic acid anions for their respective receptors GPR7, GPR8 and GPR40, GPR41, GPR43.	Carboxylic Acids	82-97	neuropeptides B and W receptor 2	Homo sapiens	142-146
14607257-7	2003	Here, we briefly summarize the recent identification of neuropeptides W and B and carboxylic acid anions for their respective receptors GPR7, GPR8 and GPR40, GPR41, GPR43.	Carboxylic Acids	82-97	free fatty acid receptor 1	Homo sapiens	151-156
14607257-7	2003	Here, we briefly summarize the recent identification of neuropeptides W and B and carboxylic acid anions for their respective receptors GPR7, GPR8 and GPR40, GPR41, GPR43.	Carboxylic Acids	82-97	free fatty acid receptor 3	Homo sapiens	158-163
14607257-7	2003	Here, we briefly summarize the recent identification of neuropeptides W and B and carboxylic acid anions for their respective receptors GPR7, GPR8 and GPR40, GPR41, GPR43.	Carboxylic Acids	82-97	free fatty acid receptor 2	Homo sapiens	165-170
14629142-0	2003	Regio- and stereoselective C-2 and C-3 cleavage of 2-(1-aminoalkyl)aziridines with alcohols, carboxylic acids, and sodium iodide.	Carboxylic Acids	93-109	complement C2	Homo sapiens	27-30
14629142-0	2003	Regio- and stereoselective C-2 and C-3 cleavage of 2-(1-aminoalkyl)aziridines with alcohols, carboxylic acids, and sodium iodide.	Carboxylic Acids	93-109	complement C3	Homo sapiens	35-38
14629142-2	2003	Depending on the nucleophile used, aziridines 1 are cleaved at C-3 or C-2 with total regio- and stereoselectivity, affording chiral 2-alkoxy-1,3-diamines 2 with alcohols, or O-acylated-1-hydroxy-2,3-diamines 6 with carboxylic acids in moderate or high yield.	Carboxylic Acids	215-231	complement C2	Homo sapiens	70-73
12606640-2	2003	Bimatoprost (AGN 192024) is also a pharmacologically novel PGF(2alpha) analog, where the carboxylic acid is replaced by a neutral ethylamide substituent.	Carboxylic Acids	89-104	placental growth factor	Homo sapiens	59-62
12925531-2	2003	Several modes of inhibitor binding in the COX active site have been described including ion pairing of carboxylic acid containing inhibitors with Arg-120 of COX-1 and COX-2 and insertion of arylsulfonamides and sulfones into the COX-2 side pocket.	Carboxylic Acids	103-118	cytochrome c oxidase I, mitochondrial	Mus musculus	157-162
12925531-2	2003	Several modes of inhibitor binding in the COX active site have been described including ion pairing of carboxylic acid containing inhibitors with Arg-120 of COX-1 and COX-2 and insertion of arylsulfonamides and sulfones into the COX-2 side pocket.	Carboxylic Acids	103-118	cytochrome c oxidase II, mitochondrial	Mus musculus	167-172
12901672-8	2003	Further oxidation cleaved the hydroxylated 4-5 and/or 6-7 bond of Adda to form aldehyde or ketone peptide residues, which then were oxidized into the corresponding carboxylic acids.	Carboxylic Acids	164-180	adducin 1	Homo sapiens	66-70
12830881-3	2003	Excellent simultaneous separation and relatively highly sensitive conductimetric detection for these C1-C7 aliphatic carboxylic acids were achieved on the TSKgel SCX column (150 x 6 mm I.D.)	Carboxylic Acids	117-133	scleraxis bHLH transcription factor	Homo sapiens	162-165
12830882-5	2003	Excellent simultaneous separation and relatively high sensitive conductimetric detection for these C1-C6 aliphatic carboxylic acids were achieved in 25 min on the TSKgel SCX column (150 x 6 mm I.D.)	Carboxylic Acids	115-131	scleraxis bHLH transcription factor	Homo sapiens	170-173
12723952-8	2003	The biological studies showed that regardless of the point of attachment, all of the short-chain carboxylic acids, C-1 to C-3, were devoid of hormonal action, while many of the esters were estrogenic.	Carboxylic Acids	97-113	T cell receptor gamma constant 1	Homo sapiens	115-125
12686489-1	2003	The metabolic conjugation of exogenous and endogenous carboxylic acid substrates with endogenous glucuronic acid, mediated by the uridine diphosphoglucuronosyl transferase (UGT) superfamily of enzymes, leads to the formation of acyl glucuronide metabolites.	Carboxylic Acids	54-69	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	130-171
12686489-1	2003	The metabolic conjugation of exogenous and endogenous carboxylic acid substrates with endogenous glucuronic acid, mediated by the uridine diphosphoglucuronosyl transferase (UGT) superfamily of enzymes, leads to the formation of acyl glucuronide metabolites.	Carboxylic Acids	54-69	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	173-176
14504849-1	2003	OBJECTIVE: Losartan is metabolized to the active carboxylic acid metabolite EXP3174 by CYP2C9.	Carboxylic Acids	49-64	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	87-93
12888560-5	2003	We have screened a library of 720 structurally diverse commercially available carboxylic acids and identified 26 YopH inhibitors with IC50 values below 100 mum.	Carboxylic Acids	78-94	YopH	Yersinia pestis	113-117
12877578-0	2003	Selective protein tyrosine phosphatase 1B inhibitors: targeting the second phosphotyrosine binding site with non-carboxylic acid-containing ligands.	Carboxylic Acids	113-128	protein tyrosine phosphatase non-receptor type 1	Homo sapiens	10-41
12643901-3	2003	The SAR of the amino acid indicates that the carboxylic acid is required for inhibition and that L-histidine is the most favored amino acid.	Carboxylic Acids	45-60	sarcosine dehydrogenase	Homo sapiens	4-7
12734796-5	2003	Pdr12p appears to confer resistance to those carboxylic acids that, to a reasonable degree, partition into both the lipid bilayer and aqueous phases.	Carboxylic Acids	45-61	ATP-binding cassette multidrug transporter PDR12	Saccharomyces cerevisiae S288C	0-6
12496283-0	2003	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	Carboxylic Acids	105-121	free fatty acid receptor 3	Homo sapiens	39-44
12496283-0	2003	The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids.	Carboxylic Acids	105-121	free fatty acid receptor 2	Homo sapiens	49-54
12496284-2	2003	Ligand fishing experiments in HEK293 cells expressing human GPR40 revealed that a range of saturated and unsaturated carboxylic acids with carbon chain lengths greater than six were able to induce an elevation of [Ca(2+)](i), measured using a fluorometric imaging plate reader.	Carboxylic Acids	117-133	free fatty acid receptor 1	Homo sapiens	60-65
12565949-2	2003	Condensation of N-substituted amino acids or carboxylic acids containing polyether moiety with leinamycin resulted in the C-8 ester derivatives with good antitumor activity in several experimental models.	Carboxylic Acids	45-61	homeobox C8	Homo sapiens	122-125
12580614-6	2003	For the catalase and epoxidation reaction types, a marked reactivity enhancement is observed for the xanthene-bridged platform appended with a pendant carboxylic acid group, establishing that this approach can yield superior catalysts to analogues that do not control both proton and electron inventories.	Carboxylic Acids	151-166	catalase	Homo sapiens	8-16
12882297-0	2003	Lipase-catalyzed condensation of p-methoxyphenethyl alcohol and carboxylic acids with different steric and electrical properties in acetonitrile.	Carboxylic Acids	64-80	PAN0_003d1715	Moesziomyces antarcticus	0-6
12882297-1	2003	The substrate selectivity of Candida antarctica lipase for various carboxylic acids was systematically investigated for their condensation with p-methoxyphenethyl alcohol in acetonitrile.	Carboxylic Acids	67-83	PAN0_003d1715	Moesziomyces antarcticus	48-54
12236748-8	2002	Reaction of Li2 with carboxylic acids in DMSO results in acid-dependent decarboxylation of 2(-) with a rate that is dependent on the concentration of the acid and its pK(a).	Carboxylic Acids	21-37	ATP binding cassette subfamily A member 12	Homo sapiens	12-15
12413844-2	2002	The nitro group was predicted to bind to the Tyr48 and His110 active site residues of the enzyme, the site where acidic ALR2 inhibitors such as carboxylic acids bind in their anionic form.	Carboxylic Acids	144-160	aldo-keto reductase family 1 member B	Homo sapiens	120-124
12213451-1	2002	5-Substituted-1H-tetrazoles (RCN4H) are often used as metabolism-resistant isosteric replacements for carboxylic acids (RCO2H) in SAR-driven medicinal chemistry analogue syntheses.	Carboxylic Acids	102-118	sarcosine dehydrogenase	Homo sapiens	130-133
12546415-4	2002	According to the structure-activity relationship, including authentic thielavins C, D and 3 partial hydrolysates from thielavins A and B, 3 benzoic acid-units and carboxylic acid functions are essential for G6Pase inhibition.	Carboxylic Acids	163-178	glucose-6-phosphatase catalytic subunit 1	Rattus norvegicus	207-213
12203290-9	2002	Hence, solid-state measurements of the alpha phase of PTMA radical provided evidence of the intradimer interaction to confirm the transmission of a weak ferromagnetic interaction through the carboxylic acid bridges, as found for the NOA radical.	Carboxylic Acids	191-206	prothymosin alpha	Homo sapiens	54-58
12393206-5	2002	The transcription rate of the zwf-pgl-eda-operon was found to be about three times higher in the KT2440 background than in strain H. In both strains the induction of the zwf-pgl-eda-operon by carbohydrates during growth on carboxylic acids was not affected by carbon catabolite repression.	Carboxylic Acids	223-239	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	Pseudomonas putida KT2440	38-41
12393206-5	2002	The transcription rate of the zwf-pgl-eda-operon was found to be about three times higher in the KT2440 background than in strain H. In both strains the induction of the zwf-pgl-eda-operon by carbohydrates during growth on carboxylic acids was not affected by carbon catabolite repression.	Carboxylic Acids	223-239	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	Pseudomonas putida KT2440	178-181
11950844-7	2002	When six of the negatively charged carboxylic acid residues are replaced by their cognate amides, reducing net negative charge to B3, but increasing helical propensity as assessed by circular dichroism, the peptide stimulates CFTR channel function, but does not inhibit.	Carboxylic Acids	35-50	CF transmembrane conductance regulator	Homo sapiens	226-230
12193017-3	2002	The resin-bound C-10 acylated paclitaxel derivatives (6a-6e) were then treated with various carboxylic acids in the presence of 1,3-diisopropylcarbodiimide in toluene to provide polymer-supported 7,10-diacylpaclitaxels (8a-8u).	Carboxylic Acids	92-108	homeobox C10	Homo sapiens	16-20
12027654-1	2002	[reaction: see text] Prenyl (3-methylbut-2-enyl) ester is catalytically cleaved by TMS triflate affording carboxylic acid and isoprene in high yield under mild conditions with high chemoselectivity without causing epimerization of the neighboring chiral center.	Carboxylic Acids	106-121	PYD and CARD domain containing	Homo sapiens	83-86
12036871-5	2002	Changes to most of the carboxylic acids in this region resulted in decreased reactivity to VWF.	Carboxylic Acids	23-39	von Willebrand factor	Homo sapiens	91-94
11914097-0	2002	Mechanistic analyses of catalysis in human pancreatic alpha-amylase: detailed kinetic and structural studies of mutants of three conserved carboxylic acids.	Carboxylic Acids	139-155	amylase alpha 2A	Homo sapiens	43-67
16290612-6	2002	The miscibility apparently decreases with increasing chain length of the carboxylic acids (C15>C17>C19).	Carboxylic Acids	73-89	placenta associated 8	Homo sapiens	91-94
16290612-6	2002	The miscibility apparently decreases with increasing chain length of the carboxylic acids (C15>C17>C19).	Carboxylic Acids	73-89	cytokine like 1	Homo sapiens	98-101
11950315-2	2002	The oxidation of N-alkylamides by O(2), catalyzed by N-hydroxyphthalimide (NHPI) and Co(II) salt, leads under mild conditions to carbonyl derivatives (aldehydes, ketones, carboxylic acids, imides) whose distribution depends on the nature of the alkyl group and on the reaction conditions.	Carboxylic Acids	171-187	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	85-91
11914097-1	2002	The roles of three conserved active site carboxylic acids (D197, E233, and D300) in the catalytic mechanism of human pancreatic alpha-amylase (HPA) were studied by utilizing site-directed mutagenesis in combination with structural and kinetic analyses of the resultant enzymes.	Carboxylic Acids	41-57	amylase alpha 2A	Homo sapiens	117-141
11886806-4	2002	Besides retrieving several carboxylic acid derivatives, which are known to generally inhibit aldose reductase, docking proposed other families of putative inhibitors such as sulfonic acids, nitro-derivatives, sulfonamides and carbonyl derivatives.	Carboxylic Acids	27-42	aldo-keto reductase family 1 member B	Homo sapiens	93-109
11724238-3	2001	While addition of a basic residue did not improve the affinity of the inhibitor, a carboxylic acid attached to the phenyl ring increased the PK selectivity of the inhibitor.	Carboxylic Acids	83-98	kallikrein B1	Homo sapiens	141-143
11906294-6	2002	Variation of the size and the substituents of the cyclic system as well as the length of the carboxylic acid resulted in enhanced Ras/Raf interaction.	Carboxylic Acids	93-108	zinc fingers and homeoboxes 2	Homo sapiens	134-137
11844670-0	2002	Design and synthesis of peptide-based carboxylic acid-containing transition-state inhibitors of human neutrophil elastase.	Carboxylic Acids	38-53	elastase, neutrophil expressed	Homo sapiens	102-121
11844670-1	2002	In our search for a new agent, human neutrophil elastase (HNE) inhibitor, for the treatment of acute respiratory failure, we rationally designed and synthesized a series of peptide-based carboxylic acid-containing transition-state inhibitors.	Carboxylic Acids	187-202	elastase, neutrophil expressed	Homo sapiens	37-56
11844670-1	2002	In our search for a new agent, human neutrophil elastase (HNE) inhibitor, for the treatment of acute respiratory failure, we rationally designed and synthesized a series of peptide-based carboxylic acid-containing transition-state inhibitors.	Carboxylic Acids	187-202	elastase, neutrophil expressed	Homo sapiens	58-61
11786336-1	2002	We investigated the electron transfer (ET) rates between a well-defined gold electrode and cytochrome c immobilized at the carboxylic acid terminus of alkanethiol self-assembled monolayers (SAMs) by using the potential modulated electroreflectance technique.	Carboxylic Acids	123-138	cytochrome c, somatic	Homo sapiens	91-103
11786336-5	2002	This "gating" process arises from a rearrangement of the cytochrome c from a thermodynamically stable binding form on the carboxylic acid terminus to a configuration, which facilitates the most efficient ET pathways (surface diffusion process).	Carboxylic Acids	122-137	cytochrome c, somatic	Homo sapiens	57-69
11738621-1	2002	We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.	Carboxylic Acids	184-200	thyrotropin releasing hormone	Homo sapiens	57-86
11738621-1	2002	We report synthesis and biological activities of several thyrotropin-releasing hormone (TRH) analogues in which the N-terminal pyroglutamic acid residue has been replaced with various carboxylic acids and the central histidine is modified with substituted-imidazole derivatives.	Carboxylic Acids	184-200	thyrotropin releasing hormone	Homo sapiens	88-91
12076093-7	2002	Significant MREC protection was achieved by the superoxide scavengers SOD (1000 U ml(-1)) and a carboxylic acid derivative of carboxyfullerene (10 microM), the xanthine oxidase inhibitors oxypurinol (100 microM) and diphenyleneiodonium (DPI) (100 n M), and the cyclooxygenase inhibitors indomethacin (300 microM) and ibuprofen (300 microM).	Carboxylic Acids	96-111	xanthine dehydrogenase	Mus musculus	160-176
11745537-3	2002	XPS of acid-treated enamel demonstrated for all carboxylic acids ionic bonding to calcium of HAp.	Carboxylic Acids	48-64	reticulon 3	Homo sapiens	93-96
11700125-1	2001	[reaction--see text] Carboxylic acids possessing strongly electron withdrawing substituents in the alpha-position in the presence of DCC acylate sterically hindered and chemically sensitive alcohols.	Carboxylic Acids	21-37	DCC netrin 1 receptor	Homo sapiens	133-136
11513858-4	2001	Leu167 is important for the interaction with alpha(4) integrins, as is the C-terminal carboxylic acid of Arg168 exposed by thrombin cleavage.	Carboxylic Acids	86-101	coagulation factor II, thrombin	Homo sapiens	123-131
11693915-3	2001	Phenylacrylic acid decarboxylase (Pad1p) catalyses a decarboxylation step, by which aromatic carboxylic acids are converted to the corresponding vinyl derivatives.	Carboxylic Acids	93-109	phenylacrylic acid decarboxylase PAD1	Saccharomyces cerevisiae S288C	34-39
15348232-2	2001	Hirudin can block the active site of thrombin by means of its carboxylic acid reaction with the active regime of thrombin, and becomes a tightly bound complex, and thus controls the formation of thrombus.	Carboxylic Acids	62-77	coagulation factor II, thrombin	Homo sapiens	37-45
15348232-2	2001	Hirudin can block the active site of thrombin by means of its carboxylic acid reaction with the active regime of thrombin, and becomes a tightly bound complex, and thus controls the formation of thrombus.	Carboxylic Acids	62-77	coagulation factor II, thrombin	Homo sapiens	113-121
11572378-14	2001	These results agree with a binding site model involving more than one carboxylic acid group, providing charge complementarity and hydrogen bond donors for binding of L-PA.	Carboxylic Acids	70-85	lipoprotein(a)	Homo sapiens	166-170
11504641-3	2001	Modification of the right-hand side of the compounds by incorporation of a free carboxylic acid resulted in a few potent human beta(3) agonists with low affinities for beta(1)- and beta(2)-ARs.	Carboxylic Acids	80-95	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	127-134
11456069-6	2001	A plateau in bFGF binding was observed for heparinized E/N14C containing approximately 2.0-3.0 wt% of immobilized heparin which was obtained using a molar ratio of EDC to heparin-carboxylic acid groups of 0.4 during heparin immobilization (E/N14C-H(0.4)).	Carboxylic Acids	179-194	fibroblast growth factor 2	Homo sapiens	13-17
29711974-1	2001	The precatalyst [Cp*RuCl(cod)] promotes the head-to-head cyclodimerization of propargylic alcohols and the formation of novel alkylidene cyclobutenes (see scheme; Cp*=C5 Me5 , cod=1,5-cyclooctadiene) by addition of carboxylic acid to the Ru(eta4 -cyclobutadiene) intermediate and dehydration.	Carboxylic Acids	215-230	FAT atypical cadherin 1	Homo sapiens	170-173
11504641-3	2001	Modification of the right-hand side of the compounds by incorporation of a free carboxylic acid resulted in a few potent human beta(3) agonists with low affinities for beta(1)- and beta(2)-ARs.	Carboxylic Acids	80-95	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2	Homo sapiens	168-176
11440563-1	2001	[reaction: see text]anti-Oximes of 2-pyridylacetic acid esters are rapidly transformed to pyridine-2-carbonitrile under a variety of conditions while syn-oximes bearing tert-butyl esters can be conveniently deprotected to the corresponding carboxylic acid with subsequent fragmentation to the nitrile.	Carboxylic Acids	240-255	synemin	Homo sapiens	150-153
11054425-2	2001	In the present study, we observed that alpha-naphthoflavone (alpha-NF) exhibited a differential effect on CYP3A4-mediated product formation as shown by an increase and decrease, respectively, of the carboxylic acid (P(2)) and omega-3-hydroxylated (P(1)) metabolites of losartan, while losartan was found to be an inhibitor of the formation of the 5,6-epoxide of alpha-NF.	Carboxylic Acids	199-214	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	106-112
11297176-4	2001	The chemical analysis of absorbed residues in archaeological pottery is well established, and through the investigation of ceramic vessels (via gas chromatography, gas chromatography-mass spectrometry and gas chromatography-combustion-isotope ratio mass spectrometry) saturated carboxylic acids in the range C12 to C18 have been detected (with an unusually high abundance of C12) from vessels from the Nubian site of Qasr Ibrim.	Carboxylic Acids	278-294	Bardet-Biedl syndrome 9	Homo sapiens	315-318
11525507-7	2001	Thus, a major function of NIT1, NIT2 and NIT3 is assigned to be the conversion to carboxylic acids of nitriles from glucosinolate turnover or degradation.	Carboxylic Acids	82-98	nitrilase 1	Arabidopsis thaliana	26-30
11525507-7	2001	Thus, a major function of NIT1, NIT2 and NIT3 is assigned to be the conversion to carboxylic acids of nitriles from glucosinolate turnover or degradation.	Carboxylic Acids	82-98	nitrilase 2	Arabidopsis thaliana	32-36
11525507-7	2001	Thus, a major function of NIT1, NIT2 and NIT3 is assigned to be the conversion to carboxylic acids of nitriles from glucosinolate turnover or degradation.	Carboxylic Acids	82-98	nitrilase 3	Arabidopsis thaliana	41-45
11166796-2	2001	FALDH catalyzes the oxidation of medium- and long-chain fatty aldehydes to their corresponding carboxylic acids.	Carboxylic Acids	95-111	aldehyde dehydrogenase 3 family member A2	Homo sapiens	0-5
11358690-5	2001	Derivatives of GW-5638 with alterations at the carboxylic acid still showed increased ERbeta potency compared to ERalpha, but the magnitude of the activation with ERalpha was much higher than with ERbeta.	Carboxylic Acids	47-62	estrogen receptor 2	Rattus norvegicus	86-92
11229773-0	2001	Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3" group chirality.	Carboxylic Acids	104-119	matrix metallopeptidase 3	Homo sapiens	53-58
11229773-0	2001	Selectivity of inhibition of matrix metalloproteases MMP-3 and MMP-2 by succinyl hydroxamates and their carboxylic acid analogues is dependent on P3" group chirality.	Carboxylic Acids	104-119	matrix metallopeptidase 2	Homo sapiens	63-68
11229773-1	2001	Structure-activity relationships are described for a series of succinyl hydroxamic acids 1a-o and their carboxylic acid analogues 2a-o as inhibitors of matrix metalloproteases MMP-3 and MMP-2.	Carboxylic Acids	104-119	matrix metallopeptidase 3	Homo sapiens	176-181
11229773-1	2001	Structure-activity relationships are described for a series of succinyl hydroxamic acids 1a-o and their carboxylic acid analogues 2a-o as inhibitors of matrix metalloproteases MMP-3 and MMP-2.	Carboxylic Acids	104-119	matrix metallopeptidase 2	Homo sapiens	186-191
11000005-10	2000	The results suggest that CCK(1) and CCK(2) receptors recognize enatiomeric dispositions of the Trp(30) indole, Asp(32) carboxylic acid, and C-terminal phenyl groups arrayed about a common backbone configuration.	Carboxylic Acids	119-134	C-C motif chemokine ligand 28	Homo sapiens	25-31
11106612-3	2000	A difference band at 1744 cm(-1) (+)/1727 cm(-1) (-) was identified in the FTIR-difference spectrum of rhodopsin mutant D83N/E122Q in which spectral difference bands arising from the carbonyl stretching frequencies of protonated carboxylic acid groups were removed by mutation.	Carboxylic Acids	229-244	rhodopsin	Homo sapiens	103-112
11055335-3	2000	N-Terminal truncation resulted in tetrapeptides containing a C-terminal carboxylic acid, which exhibited low micromolar activity against the HCV serine protease.	Carboxylic Acids	72-87	coagulation factor II, thrombin	Homo sapiens	145-160
11020292-3	2000	Structure-affinity relationship studies show that a C-terminal free carboxylic acid and an S configuration of the Phe and betaHph residues are favorable for CCK(1) receptor recognition.	Carboxylic Acids	68-83	C-C motif chemokine ligand 28	Homo sapiens	157-163
11033414-1	2000	Oxidation of 1-O-hexadec-1"-enyl-arachidonoyl glycerophosphocholine (16:0p/20:4-GPC) by hydroxyl radical generated from Cu(II)/H(2)O(2) was found to yield major products corresponding to free carboxylic acids of 5-hydroxyeicosatetraenoic acid and several 5, 12-dihydroxyeicosatetraenoic acid.	Carboxylic Acids	192-208	glycophorin C (Gerbich blood group)	Homo sapiens	80-83
11033414-4	2000	When mixed micelles of 16:0p/20:4-GPC were treated with Cu(II)/H(2)O(2), oxidation of the arachidonate esterified to the plasmalogen glycerophosphocholine lipid resulted in the most abundant products oxidized at carbon-5 of esterified arachidonate, but free carboxylic acid products were not formed.	Carboxylic Acids	258-273	glycophorin C (Gerbich blood group)	Homo sapiens	34-37
11000005-10	2000	The results suggest that CCK(1) and CCK(2) receptors recognize enatiomeric dispositions of the Trp(30) indole, Asp(32) carboxylic acid, and C-terminal phenyl groups arrayed about a common backbone configuration.	Carboxylic Acids	119-134	cholecystokinin	Homo sapiens	25-28
10956053-1	2000	A highly conserved carboxylic acid residue in rhodopsin, Glu(134), modulates transducin (G(t)) interaction.	Carboxylic Acids	19-34	rhodopsin	Homo sapiens	46-55
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	Carboxylic Acids	216-231	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	4-31
11465080-2	2000	The UDP-glucuronosyltransferase (UGT) family catalyzes the glucuronidation of the glycosyl group of a nucleotide sugar to an acceptor compound (aglycone) at a nucleophilic functional group of oxygen (eg, hydroxyl or carboxylic acid groups), nitrogen (eg, amines), sulfur (eg, thiols), and carbon, with the formation of a beta-D-glucuronide product.	Carboxylic Acids	216-231	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	33-36
11465081-2	2000	Three human UDP-glucuronosyltransferases (UGTs) catalyzing the hepatic glucuronidation of carboxylic acid drugs have been identified, UGT1A3, UGT1A9 and a UGT2B7 variant.	Carboxylic Acids	90-105	beta-1,3-glucuronyltransferase 2	Homo sapiens	12-40
11465081-2	2000	Three human UDP-glucuronosyltransferases (UGTs) catalyzing the hepatic glucuronidation of carboxylic acid drugs have been identified, UGT1A3, UGT1A9 and a UGT2B7 variant.	Carboxylic Acids	90-105	beta-1,3-glucuronyltransferase 2	Homo sapiens	42-46
11465081-2	2000	Three human UDP-glucuronosyltransferases (UGTs) catalyzing the hepatic glucuronidation of carboxylic acid drugs have been identified, UGT1A3, UGT1A9 and a UGT2B7 variant.	Carboxylic Acids	90-105	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	134-140
11465081-2	2000	Three human UDP-glucuronosyltransferases (UGTs) catalyzing the hepatic glucuronidation of carboxylic acid drugs have been identified, UGT1A3, UGT1A9 and a UGT2B7 variant.	Carboxylic Acids	90-105	UDP glucuronosyltransferase family 1 member A9	Homo sapiens	142-148
11465081-2	2000	Three human UDP-glucuronosyltransferases (UGTs) catalyzing the hepatic glucuronidation of carboxylic acid drugs have been identified, UGT1A3, UGT1A9 and a UGT2B7 variant.	Carboxylic Acids	90-105	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	155-161
10759065-5	2000	In vitro, NTE potently catalyses hydrolysis of phenyl valerate: however, its physiological substrate is likely to be a metabolite of a much longer chain carboxylic acid, possibly associated with cell membranes.	Carboxylic Acids	153-168	patatin like phospholipase domain containing 6	Homo sapiens	10-13
10862684-2	2000	The carboxylic acid and amine precursors are based on 3-hydroxybutyrate and 4-amino-1-butanol, respectively, and have been acylated selectively using a variety of acyl donors catalyzed by porcine pancreatic lipase.	Carboxylic Acids	4-19	pancreatic lipase	Homo sapiens	196-213
10882025-2	2000	In the search for aldose reductase inhibitors less acidic than carboxylic acids, phenolic compounds related to benzopyran-4-one and chalcone are particularly interesting because they possess good inhibitory properties.	Carboxylic Acids	63-79	aldo-keto reductase family 1 member B	Homo sapiens	18-34
9928161-5	1998	NH2-terminal carboxylic acid analogs of galanin (1-16) have a very low affinity for the wild-type receptor, but substantially increased affinity for the Glu271Lys-hGalR1, suggesting that the NH2-terminus of galanin binds to the receptor near the transmembrane (TM) VI.	Carboxylic Acids	13-28	galanin receptor 1	Homo sapiens	163-169
11220344-3	2000	Selectivity control by the addition of Ca2+ to the carrier electrolyte made possible a baseline resolved separation of 14 carboxylic acids.	Carboxylic Acids	122-138	carbonic anhydrase 2	Homo sapiens	39-42
10640649-7	2000	Maximal bFGF binding was observed for E/N14C containing 20-30 mg heparin immobilized per gram of collagen which was obtained using a molar ratio of EDC to heparin-carboxylic acid groups of 0.4 for heparin immobilization (E/N14C-H(0.4)).	Carboxylic Acids	163-178	fibroblast growth factor 2	Homo sapiens	8-12
10639181-11	2000	Expansion of this approach can be envisioned for the modification of all carboxylic acid-containing NSAIDs into selective COX-2 inhibitors.	Carboxylic Acids	73-88	prostaglandin-endoperoxide synthase 2	Mus musculus	122-127
10901286-4	2000	RT-PCR experiments indicated that the PD-7 and TC-7 clones expressed the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A3 and UGT2B7, which could account for the glucuronidation of phenols and carboxylic acids observed.	Carboxylic Acids	202-218	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	73-100
10901286-4	2000	RT-PCR experiments indicated that the PD-7 and TC-7 clones expressed the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A3 and UGT2B7, which could account for the glucuronidation of phenols and carboxylic acids observed.	Carboxylic Acids	202-218	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	102-105
10901286-4	2000	RT-PCR experiments indicated that the PD-7 and TC-7 clones expressed the UDP-glucuronosyltransferase (UGT) isoforms UGT1A6, UGT1A3 and UGT2B7, which could account for the glucuronidation of phenols and carboxylic acids observed.	Carboxylic Acids	202-218	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	135-141
10639274-10	1999	These results support the hypothesis that the spatial relationship between the carboxylic acid and allylic hydroxyl functions is crucial for high binding affinity with BLTR.	Carboxylic Acids	79-94	leukotriene B4 receptor	Homo sapiens	168-172
10521266-0	1999	Analysis of the binding of hydroxamic acid and carboxylic acid inhibitors to the stromelysin-1 (matrix metalloproteinase-3) catalytic domain by isothermal titration calorimetry.	Carboxylic Acids	47-62	matrix metallopeptidase 3	Homo sapiens	81-94
10328974-6	1999	Aldose reductase inhibitors possessing either hydantoin or carboxylic acid groups prevented protein modification induced by naphthalene-1, 2-dihydrodiol but not protein modification induced by 1, 2-dihydroxynaphthalene or 1,2-naphthoquinone.	Carboxylic Acids	59-74	aldo-keto reductase family 1 member B1	Rattus norvegicus	0-16
10328974-8	1999	Lens proteins modified by naphthalene-1,2-dihydrodiol appear essentially identical to protein adducts formed with 1,2-naphthoquinone and their formation can be prevented by both hydantoin and carboxylic acid containing aldose reductase inhibitors.	Carboxylic Acids	192-207	aldo-keto reductase family 1 member B1	Rattus norvegicus	219-235
10212389-4	1999	High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule.	Carboxylic Acids	92-107	retinoic acid receptor alpha	Homo sapiens	52-74
10212389-4	1999	High retinoidal activity (agonist or antagonist for retinoic acid receptor (RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule.	Carboxylic Acids	92-107	retinoic acid receptor alpha	Homo sapiens	76-79
9895414-2	1999	Various coupling reaction conditions were tested to optimize the conjugation process between a hydroxyl terminal group of PLGA and a carboxylic acid group of Fmoc-Trp(Boc).	Carboxylic Acids	133-148	BOC cell adhesion associated, oncogene regulated	Homo sapiens	158-171
10742211-6	2000	Interestingly, the GDH-producing lactococcal strain produced a higher proportion of carboxylic acids, which are major aroma compounds.	Carboxylic Acids	84-100	gdh	Lactococcus lactis	19-22
10711632-1	2000	The effect of monovalent cation on the activity of the XL-I and XL-III forms of xenobiotic/medium-chain fatty acid:CoA ligase (XM-ligase) was investigated using a variety of different carboxylic acid substrates.	Carboxylic Acids	184-199	steroid sulfatase	Homo sapiens	55-59
10465408-4	1999	The ring or fused ring system occupying the outermost TTR binding pocket needs to be substituted with an acidic functional group (e.g. a carboxylic acid) to interact with complimentary charges in the TTR binding site.	Carboxylic Acids	137-152	transthyretin	Homo sapiens	54-57
10465408-4	1999	The ring or fused ring system occupying the outermost TTR binding pocket needs to be substituted with an acidic functional group (e.g. a carboxylic acid) to interact with complimentary charges in the TTR binding site.	Carboxylic Acids	137-152	transthyretin	Homo sapiens	200-203
10319433-4	1999	High retinoidal activity (agonist or antagonist for the retinoid receptor RAR) requires a carboxylic acid moiety and an appropriate hydrophobic group located at a suitable position on the molecule.	Carboxylic Acids	90-105	RAB40B, member RAS oncogene family	Homo sapiens	74-77
10201825-1	1999	An efficient solid-phase synthesis of benzisothiazolone-1,1-dioxide-based serine protease inhibitors involving alkylation of carboxylic acids with N-(bromomethyl)benzisothiazolone-1,1-dioxide has been developed.	Carboxylic Acids	125-141	coagulation factor II, thrombin	Homo sapiens	74-89
10091666-1	1999	Human pancreatic alpha-amylase (HPA) was expressed in the methylotrophic yeast Pichia pastoris and two mutants (D197A and D197N) of a completely conserved active site carboxylic acid were generated.	Carboxylic Acids	167-182	amylase alpha 2A	Homo sapiens	6-30
10091603-9	1999	These findings reveal an important conserved role for ALDH1 in retinoic acid synthesis in vivo, and demonstrate that conversion of retinoids from the aldehyde form to the carboxylic acid form is a crucial regulatory step in retinoid signaling.	Carboxylic Acids	171-186	aldehyde dehydrogenase 1 family member A1 L homeolog	Xenopus laevis	54-59
9790671-5	1998	These pKs are consistent with the involvement of two carboxylic acids, possibly E202(199) and either E334(327) or E450(443), and H447(440)H+ in the dealkylation of AChE.	Carboxylic Acids	53-69	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-168
9370372-6	1997	N-terminal carboxylic acid analogues of galanin have low affinity to wild-type GalR1, but substantially increased affinity to the Glu271Lys receptor mutant.	Carboxylic Acids	11-26	galanin receptor 1	Homo sapiens	79-84
9733775-8	1998	The alpha5-(229-448)-fibronectin complex is dissociated in the presence of an RGD peptide, as well as of a simple carboxylic acid, suggesting that the RGD aspartyl carboxylate is an essential element that directly interacts with the alpha5 cation-binding domain.	Carboxylic Acids	114-129	fibronectin 1	Homo sapiens	21-32
9668345-5	1998	MAG binding was abrogated by modification of the carboxylic acid, any hydroxyl, or the N-acetyl group of the ganglioside"s N-acetylneuraminic acid moiety.	Carboxylic Acids	49-64	myelin associated glycoprotein	Homo sapiens	0-3
9616184-6	1998	The reactivity of expressed human UGT1A3 toward hydroxylated and carboxylic acid-containing compounds was also examined.	Carboxylic Acids	65-80	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	34-40
9616184-8	1998	Drugs containing a carboxylic acid moiety, such as nonsteroidal anti-inflammatory agents (e.g. naproxen and ibuprofen) and fibrates (e.g. ciprofibrate), were substrates for human UGT1A3.	Carboxylic Acids	19-34	UDP glucuronosyltransferase family 1 member A3	Homo sapiens	179-185
9810690-2	1998	Glycoconjugates of AVP modified at the N-terminal amide (12a-e) were also synthesized from AVP and carboxylic acids (3a-e) using dicyclohexylcarbodiimide and 1-hydroxybenzotriazole as coupling agent.	Carboxylic Acids	99-115	arginine vasopressin	Rattus norvegicus	19-22
9726932-8	1998	The 1735 cm-1 vibration is also seen in the complex with C-terminal peptides devoid of free carboxylic acid groups, indicating that the corresponding carbonyl group is located on rhodopsin.	Carboxylic Acids	92-107	rhodopsin	Bos taurus	179-188
9394029-0	1997	Glucuronidation of opioids, carboxylic acid-containing drugs, and hydroxylated xenobiotics catalyzed by expressed monkey UDP-glucuronosyltransferase 2B9 protein.	Carboxylic Acids	28-43	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	121-152
9394029-6	1997	Stably expressed UGT2B9 also catalyzes the glucuronidation of profen nonsteroidal anti-inflammatory drugs, fibrate hypolipidemic agents, and straight-chain fatty acids at the carboxylic acid moiety.	Carboxylic Acids	175-190	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	17-23
9365024-4	1997	The purpose of the present study was to modify the antioxidant enzyme, catalase (CAT), with putrescine (PUT) at carboxylic acid groups whose ionization, and hence reactivity, was controlled with pH and investigate the effects on permeability and enzymatic activity.	Carboxylic Acids	112-127	catalase	Rattus norvegicus	71-79
9278394-14	1997	The binding to cysteine 813 defines the location of the extracytoplasmic loop between TM5 and TM6 and places the carboxylic acids 820 and 824 conserved between the gastric H,K- and the Na,K-ATPases in TM6, consistent with their assumed role in cation binding.	Carboxylic Acids	113-129	tropomyosin 3	Homo sapiens	86-89
9365024-4	1997	The purpose of the present study was to modify the antioxidant enzyme, catalase (CAT), with putrescine (PUT) at carboxylic acid groups whose ionization, and hence reactivity, was controlled with pH and investigate the effects on permeability and enzymatic activity.	Carboxylic Acids	112-127	catalase	Rattus norvegicus	81-84
9238015-2	1997	Mutant forms of rhodopsin were prepared in which the carboxylic acid counterion was moved relative to the positively charged chromophore Schiff base.	Carboxylic Acids	53-68	rhodopsin	Homo sapiens	16-25