PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
28566583-0	2017	Bergamottin Promotes Adipocyte Differentiation and Inhibits Tumor Necrosis Factor-alpha-induced Inflammatory Cytokines Induction in 3T3-L1 Cells.	bergamottin	0-11	tumor necrosis factor	Mus musculus	60-87
28566583-5	2017	In addition, Bergamottin increases the expression of adiponectin, an anti-inflammatory adipokine, and peroxisome proliferator activated receptor gamma (PPARgamma), a nuclear receptor regulating adipocyte differentiation.	bergamottin	13-24	adiponectin, C1Q and collagen domain containing	Mus musculus	53-64
28566583-5	2017	In addition, Bergamottin increases the expression of adiponectin, an anti-inflammatory adipokine, and peroxisome proliferator activated receptor gamma (PPARgamma), a nuclear receptor regulating adipocyte differentiation.	bergamottin	13-24	peroxisome proliferator activated receptor gamma	Mus musculus	102-150
28566583-5	2017	In addition, Bergamottin increases the expression of adiponectin, an anti-inflammatory adipokine, and peroxisome proliferator activated receptor gamma (PPARgamma), a nuclear receptor regulating adipocyte differentiation.	bergamottin	13-24	peroxisome proliferator activated receptor gamma	Mus musculus	152-161
28566583-8	2017	Treatment with Bergamottin further decreased the TNF-alpha-induced change in IkappaBalpha expression, suggesting that Bergamottin mediated the inhibition of NF-kappaB activation.	bergamottin	15-26	tumor necrosis factor	Mus musculus	49-58
28566583-8	2017	Treatment with Bergamottin further decreased the TNF-alpha-induced change in IkappaBalpha expression, suggesting that Bergamottin mediated the inhibition of NF-kappaB activation.	bergamottin	15-26	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	77-89
28566583-8	2017	Treatment with Bergamottin further decreased the TNF-alpha-induced change in IkappaBalpha expression, suggesting that Bergamottin mediated the inhibition of NF-kappaB activation.	bergamottin	118-129	tumor necrosis factor	Mus musculus	49-58
28566583-8	2017	Treatment with Bergamottin further decreased the TNF-alpha-induced change in IkappaBalpha expression, suggesting that Bergamottin mediated the inhibition of NF-kappaB activation.	bergamottin	118-129	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	77-89
28566583-9	2017	In addition, Bergamottin decreased the TNF-alpha-induced increase in the mRNA levels of pro-inflammatory adipokines, monocyte chemoattractant protein-1 and interleukin-6.	bergamottin	13-24	tumor necrosis factor	Mus musculus	39-48
28566583-9	2017	In addition, Bergamottin decreased the TNF-alpha-induced increase in the mRNA levels of pro-inflammatory adipokines, monocyte chemoattractant protein-1 and interleukin-6.	bergamottin	13-24	chemokine (C-C motif) ligand 2	Mus musculus	117-151
28566583-9	2017	In addition, Bergamottin decreased the TNF-alpha-induced increase in the mRNA levels of pro-inflammatory adipokines, monocyte chemoattractant protein-1 and interleukin-6.	bergamottin	13-24	interleukin 6	Mus musculus	156-169
26911804-0	2016	Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-kappaB signalling pathway in human chronic myelogenous leukaemia.	bergamottin	32-43	tumor necrosis factor	Homo sapiens	56-59
26911804-0	2016	Simvastatin in combination with bergamottin potentiates TNF-induced apoptosis through modulation of NF-kappaB signalling pathway in human chronic myelogenous leukaemia.	bergamottin	32-43	nuclear factor kappa B subunit 1	Homo sapiens	100-109
16481174-0	2006	Synthesis of 8-geranyloxypsoralen analogues and their evaluation as inhibitors of CYP3A4.	bergamottin	13-33	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	82-88
24492725-3	2014	Bergamottin inhibited hMATE1 mediated tetraethyl ammonium transport activity, with a Ki of 98.7 microM.	bergamottin	0-11	solute carrier family 47 member 1	Homo sapiens	22-28
22344702-0	2012	Identification of the residue in human CYP3A4 that is covalently modified by bergamottin and the reactive intermediate that contributes to the grapefruit juice effect.	bergamottin	77-88	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-45
22344702-1	2012	Previous studies have demonstrated that bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction.	bergamottin	40-51	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-133
22344702-1	2012	Previous studies have demonstrated that bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction.	bergamottin	53-55	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	127-133
22344702-2	2012	Although the covalent binding of [(14)C]BG to the CYP3A4 apoprotein has been demonstrated by SDS-polyacrylamide gel electrophoresis, the identity of the modified amino acid residue and the reactive intermediate species of BG responsible for the inactivation have not been reported.	bergamottin	40-42	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	50-56
22344702-3	2012	In the present study, we show that inactivation of CYP3A4 by BG results in formation of a modified apoprotein-3A4 and a GSH conjugate, both exhibiting mass increases of 388 Da, which corresponds to the mass of 6",7"-dihydroxybergamottin (DHBG), a metabolite of BG, plus one oxygen atom.	bergamottin	61-63	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-57
22344702-3	2012	In the present study, we show that inactivation of CYP3A4 by BG results in formation of a modified apoprotein-3A4 and a GSH conjugate, both exhibiting mass increases of 388 Da, which corresponds to the mass of 6",7"-dihydroxybergamottin (DHBG), a metabolite of BG, plus one oxygen atom.	bergamottin	240-242	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	51-57
22344702-7	2012	In conclusion, we have determined that the reactive intermediate, oxygenated DHBG, covalently binds to Gln273 and thereby contributes to the mechanism-based inactivation of CYP3A4 by BG.	bergamottin	79-81	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	173-179
21749392-8	2011	In agreement with published data, bergamottin, a natural product known to interact with CYP3A4, was shown to inhibit CYP3A4 with an IC50 of 13.63 microm and activate PXR with an EC50 of 6.7 microm.	bergamottin	34-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	88-94
21749392-8	2011	In agreement with published data, bergamottin, a natural product known to interact with CYP3A4, was shown to inhibit CYP3A4 with an IC50 of 13.63 microm and activate PXR with an EC50 of 6.7 microm.	bergamottin	34-45	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	117-123
21749392-8	2011	In agreement with published data, bergamottin, a natural product known to interact with CYP3A4, was shown to inhibit CYP3A4 with an IC50 of 13.63 microm and activate PXR with an EC50 of 6.7 microm.	bergamottin	34-45	nuclear receptor subfamily 1 group I member 2	Homo sapiens	166-169
20885377-1	2010	Mechanism-based inactivators such as bergamottin are useful chemical tools for identifying the functions of specific active-site amino acid residues in the reactions catalyzed by cytochromes P450 (CYPs or P450s), which are responsible for the metabolism of a wide variety of drugs and endogenous substrates.	bergamottin	37-48	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	191-195
20885377-1	2010	Mechanism-based inactivators such as bergamottin are useful chemical tools for identifying the functions of specific active-site amino acid residues in the reactions catalyzed by cytochromes P450 (CYPs or P450s), which are responsible for the metabolism of a wide variety of drugs and endogenous substrates.	bergamottin	37-48	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	205-210
19148864-5	2009	Of the tested constituents, only 10 microM bergamottin and 200 microM naringenin induced MDR1 mRNA levels 2.9- and 4.0-fold, respectively (P<0.01 for both), and CYP3A4 mRNA levels 3.2- and 15.6-fold (P<0.01 for both), respectively.	bergamottin	43-54	ATP binding cassette subfamily B member 1	Homo sapiens	89-93
19148864-5	2009	Of the tested constituents, only 10 microM bergamottin and 200 microM naringenin induced MDR1 mRNA levels 2.9- and 4.0-fold, respectively (P<0.01 for both), and CYP3A4 mRNA levels 3.2- and 15.6-fold (P<0.01 for both), respectively.	bergamottin	43-54	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	164-170
18451520-7	2008	Extracts having relatively strong inhibitory effects for CYP3A4 tended to contain higher amounts of naringin, bergamottin and 6",7"-dihydroxybergamottin.	bergamottin	110-121	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	57-63
25473508-6	2014	However, bergamottin appeared to be a significant in vitro CYP1A2 inducer starting from 5 to 50 mumol/L with induction ranging from 60 to 100-fold changes.	bergamottin	9-20	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	59-65
19943262-0	2010	Suppression of phorbol-12-myristate-13-acetate-induced tumor cell invasion by bergamottin via the inhibition of protein kinase Cdelta/p38 mitogen-activated protein kinase and JNK/nuclear factor-kappaB-dependent matrix metalloproteinase-9 expression.	bergamottin	78-89	mitogen-activated protein kinase 14	Homo sapiens	134-137
19943262-3	2010	Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	bergamottin	0-11	matrix metallopeptidase 9	Homo sapiens	80-85
19943262-3	2010	Bergamottin reduced phorbol-12-myristate-13-acetate (PMA)-induced activation of MMP-9 and MMP-2 and further inhibited cell invasion and migration.	bergamottin	0-11	matrix metallopeptidase 2	Homo sapiens	90-95
19943262-4	2010	Bergamottin suppressed PMA-enhanced expression of MMP-9 protein, mRNA and transcription activity levels through suppression of nuclear factor-kappaB (NF-kappaB) activation without changing the tissue inhibitor of metalloproteinase 1 level.	bergamottin	0-11	matrix metallopeptidase 9	Homo sapiens	50-55
19943262-5	2010	Bergamottin also reduced PMA-enhanced MMP-2 expression through suppression of membrane-type 1 MMP, but did not alter tissue inhibitor of metalloproteinase 2 levels.	bergamottin	0-11	matrix metallopeptidase 2	Homo sapiens	38-43
19943262-5	2010	Bergamottin also reduced PMA-enhanced MMP-2 expression through suppression of membrane-type 1 MMP, but did not alter tissue inhibitor of metalloproteinase 2 levels.	bergamottin	0-11	matrix metallopeptidase 14	Homo sapiens	78-97
19943262-6	2010	Bergamottin inhibited PMA-induced NF-kappaB nuclear translocation and IkappaBalpha degradation, which are upstream of PMA-induced MMP-9 expression and invasion.	bergamottin	0-11	NFKB inhibitor alpha	Homo sapiens	70-82
19943262-6	2010	Bergamottin inhibited PMA-induced NF-kappaB nuclear translocation and IkappaBalpha degradation, which are upstream of PMA-induced MMP-9 expression and invasion.	bergamottin	0-11	matrix metallopeptidase 9	Homo sapiens	130-135
19943262-7	2010	Furthermore, bergamottin strongly repressed the PMA-induced phosphorylation of p38 mitogen-activated protein kinase and c-Jun N-terminal kinase (JNK), which are dependent on the protein kinase C-delta pathway.	bergamottin	13-24	mitogen-activated protein kinase 14	Homo sapiens	79-82
19943262-8	2010	In conclusion, we demonstrated that the anti-invasive effects of bergamottin might occur through inhibition of protein kinase C-delta, p38 mitogen-activated protein kinase, and JNK phosphorylation and reduction of NF-kappaB activation, leading to downregulation of MMP-9 expression.	bergamottin	65-76	mitogen-activated protein kinase 14	Homo sapiens	135-138
19943262-8	2010	In conclusion, we demonstrated that the anti-invasive effects of bergamottin might occur through inhibition of protein kinase C-delta, p38 mitogen-activated protein kinase, and JNK phosphorylation and reduction of NF-kappaB activation, leading to downregulation of MMP-9 expression.	bergamottin	65-76	matrix metallopeptidase 9	Homo sapiens	265-270
16481174-2	2006	In this study, we report the effects of a series of novel furanocoumarins based on the naturally occurring derivative 8-geranylepoxypsoralen which has been shown to be a more potent inhibitor of CYP3A4 than its 5-position-substituted counterpart bergamottin.	bergamottin	246-257	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	195-201
15860655-9	2005	Other mechanism-based inactivators we identified include bergamottin (CYP1A2 besides previously reported CYP3A4), troglitazone (CYP3A4), rosiglitazone (CYP3A4), and pioglitazone (CYP3A4).	bergamottin	57-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	70-76
16338240-8	2006	Paradisin-A was found to be a potent CYP 3A4 inhibitor with an IC50 of 1.2 microM followed by DHB and bergamottin.	bergamottin	102-113	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	37-44
15269184-1	2004	Bergamottin (BG) and 6",7"-dihydroxybergamottin (DHB) are the most abundant furanocoumarins present in grapefruit juice and have been proposed as major intestinal CYP3A4 inhibitors contributing to grapefruit juice-drug interactions.	bergamottin	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	163-169
15670584-3	2005	We have investigated the interaction of four furocoumarins angelicin, bergamottin, isopimpinellin, and 8-methoxypsoralen with the expression and activity of aryl hydrocarbon receptor (AhR)-regulated CYP1A1 in rat hepatocytes in primary culture, both in the presence and absence of light.	bergamottin	70-81	aryl hydrocarbon receptor	Rattus norvegicus	157-182
15670584-3	2005	We have investigated the interaction of four furocoumarins angelicin, bergamottin, isopimpinellin, and 8-methoxypsoralen with the expression and activity of aryl hydrocarbon receptor (AhR)-regulated CYP1A1 in rat hepatocytes in primary culture, both in the presence and absence of light.	bergamottin	70-81	aryl hydrocarbon receptor	Rattus norvegicus	184-187
15670584-3	2005	We have investigated the interaction of four furocoumarins angelicin, bergamottin, isopimpinellin, and 8-methoxypsoralen with the expression and activity of aryl hydrocarbon receptor (AhR)-regulated CYP1A1 in rat hepatocytes in primary culture, both in the presence and absence of light.	bergamottin	70-81	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	199-205
15670584-4	2005	In intact hepatocytes pretreated with 2,3,7,8-tetrachlorodibenzo-p-dioxin and in microsomes isolated thereof, all furocoumarins tested acted as potent inhibitors of CYP1A1 activity bergamottin being the most potent inhibitor in microsomes with an IC(50) of 10 nM in the presence and 60 nM in the absence of light.	bergamottin	181-192	cytochrome P450, family 1, subfamily a, polypeptide 1	Rattus norvegicus	165-171
15269184-1	2004	Bergamottin (BG) and 6",7"-dihydroxybergamottin (DHB) are the most abundant furanocoumarins present in grapefruit juice and have been proposed as major intestinal CYP3A4 inhibitors contributing to grapefruit juice-drug interactions.	bergamottin	13-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	163-169
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	141-152	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	104-111
15072439-6	2004	Some components (e.g., bergamottin and quercetin) from grapefruit juice were reported to modulate Pgp activity.	bergamottin	23-34	ATP binding cassette subfamily B member 1	Homo sapiens	98-101
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	19-30	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-83
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	19-30	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	85-92
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	19-30	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	94-102
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	19-30	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	104-111
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	19-30	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	116-123
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	141-152	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	77-83
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	141-152	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	85-92
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	141-152	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	94-102
15499170-10	2004	On the other hand, bergamottin showed time-dependent decreases in IC(50) for CYP1A2, CYP 2C9, CYP 2C19, CYP 2D6 and CYP 3A4, suggesting that bergamottin is a quasi-irrversible or an irreversible inhibitor of the 5 CYP isoforms.	bergamottin	141-152	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	116-123
12167562-6	2002	A 48-h exposure of cultured human hepatocytes to bergamottin resulted in increased levels of immunoreactive CYP3A4, CYP1A1, and CYP1A2 proteins, and CYP3A4, CYP1A1, CYP1A2, CYP2B6, and UDP-glucuronosyl transferase mRNAs.	bergamottin	49-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155
12167562-3	2002	Treatment of hepatocytes with 0.1, 1, 5, and 10 microM bergamottin resulted in a concentration-dependent reduction in CYP3A4 activity (40-100%) in both human and monkey cells, as measured by testosterone 6 beta-hydroxylase activity.	bergamottin	55-66	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	118-124
12167562-6	2002	A 48-h exposure of cultured human hepatocytes to bergamottin resulted in increased levels of immunoreactive CYP3A4, CYP1A1, and CYP1A2 proteins, and CYP3A4, CYP1A1, CYP1A2, CYP2B6, and UDP-glucuronosyl transferase mRNAs.	bergamottin	49-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	157-163
12167562-4	2002	Bergamottin was potent at eliciting these inhibitory effects at both basal and induced states of CYP3A.	bergamottin	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	97-102
12167562-6	2002	A 48-h exposure of cultured human hepatocytes to bergamottin resulted in increased levels of immunoreactive CYP3A4, CYP1A1, and CYP1A2 proteins, and CYP3A4, CYP1A1, CYP1A2, CYP2B6, and UDP-glucuronosyl transferase mRNAs.	bergamottin	49-60	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	108-114
12167562-6	2002	A 48-h exposure of cultured human hepatocytes to bergamottin resulted in increased levels of immunoreactive CYP3A4, CYP1A1, and CYP1A2 proteins, and CYP3A4, CYP1A1, CYP1A2, CYP2B6, and UDP-glucuronosyl transferase mRNAs.	bergamottin	49-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	165-171
12167562-6	2002	A 48-h exposure of cultured human hepatocytes to bergamottin resulted in increased levels of immunoreactive CYP3A4, CYP1A1, and CYP1A2 proteins, and CYP3A4, CYP1A1, CYP1A2, CYP2B6, and UDP-glucuronosyl transferase mRNAs.	bergamottin	49-60	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	116-122
12167562-6	2002	A 48-h exposure of cultured human hepatocytes to bergamottin resulted in increased levels of immunoreactive CYP3A4, CYP1A1, and CYP1A2 proteins, and CYP3A4, CYP1A1, CYP1A2, CYP2B6, and UDP-glucuronosyl transferase mRNAs.	bergamottin	49-60	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	173-179
12167562-6	2002	A 48-h exposure of cultured human hepatocytes to bergamottin resulted in increased levels of immunoreactive CYP3A4, CYP1A1, and CYP1A2 proteins, and CYP3A4, CYP1A1, CYP1A2, CYP2B6, and UDP-glucuronosyl transferase mRNAs.	bergamottin	49-60	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	128-134
12167562-8	2002	These results suggest that bergamottin causes both inhibition of CYP3A and CYP1A1/2 enzymatic activities and induction of correspondent proteins and mRNAs.	bergamottin	27-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	65-70
12167562-8	2002	These results suggest that bergamottin causes both inhibition of CYP3A and CYP1A1/2 enzymatic activities and induction of correspondent proteins and mRNAs.	bergamottin	27-38	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	75-81
9054609-16	1997	The preferential inhibitory effect of bergamottin and coriandrin on the formation of anti diol-epoxide adducts derived from DMBA was further confirmed by separation of anti- and syn-diol-epoxide-DNA adducts using immobilized boronate chromatography.	bergamottin	38-49	joined toes	Mus musculus	178-181
11849049-4	2002	HPLC analysis of DNA adducts revealed that bergamottin preferentially inhibited formation of anti-DMBA diol-epoxide (DMBADE) derived DNA adducts, imperatorin, and isopimpinellin inhibited both anti- and syn- derived adducts, whereas 7,8-BF showed some selectivity for reduction of syn-DMBADE-DNA adducts.	bergamottin	43-54	joined toes	Mus musculus	203-206
11849049-4	2002	HPLC analysis of DNA adducts revealed that bergamottin preferentially inhibited formation of anti-DMBA diol-epoxide (DMBADE) derived DNA adducts, imperatorin, and isopimpinellin inhibited both anti- and syn- derived adducts, whereas 7,8-BF showed some selectivity for reduction of syn-DMBADE-DNA adducts.	bergamottin	43-54	joined toes	Mus musculus	281-284
11792681-16	2002	In hepatic microsomes, bergamottin treatment for 10 days reduced the activity of CYP3A12 by 50% and CYP1A1/2 by 75%.	bergamottin	23-34	cytochrome P450 3A12	Canis lupus familiaris	81-88
11792681-16	2002	In hepatic microsomes, bergamottin treatment for 10 days reduced the activity of CYP3A12 by 50% and CYP1A1/2 by 75%.	bergamottin	23-34	Cytochrome P450 1A1	Canis lupus familiaris	100-106
11792681-18	2002	In jejunal microsomes, CYP3A12 activity doubled with bergamottin treatment.	bergamottin	53-64	cytochrome P450 3A12	Canis lupus familiaris	23-30
7918236-0	1994	Effects of a new psoralen, 5-geranoxypsoralen, plus UVA radiation on murine ATPase positive Langerhans cells.	bergamottin	27-45	dynein, axonemal, heavy chain 8	Mus musculus	76-82
7918236-3	1994	We investigated the effects of repetitive treatments with 5-GOP plus UVA radiation (320-400 nm) on the number of ATPase+ epidermal Langerhans cells and on the induction of photoreactivity.	bergamottin	58-63	dynein, axonemal, heavy chain 8	Mus musculus	113-119
7918236-10	1994	We conclude that phototoxicity and decrease in the number of ATPase-stained epidermal immune cells observed after treatment with 5-GOP plus UVA radiation are not related to the DNA binding activity of the psoralen.	bergamottin	129-134	dynein, axonemal, heavy chain 8	Mus musculus	61-67
34632552-0	2022	Bergamottin protects against LPS-induced endotoxic shock by regulating the NF-kappaB signaling pathway.	bergamottin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
8117927-4	1993	Notably, coriandrin and bergamottin were approximately as potent as 7,8-benzoflavone, a relatively selective inhibitor of cytochrome P450 1A1.	bergamottin	24-35	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	122-141
34632552-8	2022	Pre-treatment with Bergamottin inhibited inflammatory cytokines expression and secretion induced by LPS, due to the inhibition of LPS-induced NF-kappaB signaling pathway activation, and improved pathological damages.	bergamottin	19-30	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
34632552-9	2022	These findings suggest that Bergamottin protects against LPS-induced endotoxin shock by regulating the NF-kappaB signaling pathway.	bergamottin	28-39	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	103-112
34168462-5	2021	Methods: The effect of BGM on the melanoma progression was analyzed by CCK-8 assays, colony formation assays, transwell assays, Annexin V-FITC Apoptosis Detection Kit, cell-cycle analysis, in vivo tumorigenicity analysis.	bergamottin	23-26	annexin A5	Homo sapiens	128-137
34812690-0	2021	Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-kappaB.	bergamottin	0-11	sirtuin 1	Mus musculus	65-70
34812690-0	2021	Bergamottin alleviates LPS-induced acute lung injury by inducing SIRT1 and suppressing NF-kappaB.	bergamottin	0-11	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
34812690-3	2021	Since bergamottin is a natural furanocoumarin showing the ability to inhibit the activation of NF-kappaB, in this study we aimed to determine the effect of bergamottin on ALI.	bergamottin	6-17	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
34812690-3	2021	Since bergamottin is a natural furanocoumarin showing the ability to inhibit the activation of NF-kappaB, in this study we aimed to determine the effect of bergamottin on ALI.	bergamottin	156-167	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	95-104
34812690-7	2021	Our results showed that LPS exposure led to increased production of TNF-alpha, IL-6, and monocyte chemoattractant protein-1 (MCP-1), which was impaired by bergamottin pre-treatment.	bergamottin	155-166	tumor necrosis factor	Mus musculus	68-77
34812690-7	2021	Our results showed that LPS exposure led to increased production of TNF-alpha, IL-6, and monocyte chemoattractant protein-1 (MCP-1), which was impaired by bergamottin pre-treatment.	bergamottin	155-166	interleukin 6	Mus musculus	79-83
34812690-7	2021	Our results showed that LPS exposure led to increased production of TNF-alpha, IL-6, and monocyte chemoattractant protein-1 (MCP-1), which was impaired by bergamottin pre-treatment.	bergamottin	155-166	chemokine (C-C motif) ligand 2	Mus musculus	89-123
34812690-7	2021	Our results showed that LPS exposure led to increased production of TNF-alpha, IL-6, and monocyte chemoattractant protein-1 (MCP-1), which was impaired by bergamottin pre-treatment.	bergamottin	155-166	chemokine (C-C motif) ligand 2	Mus musculus	125-130
34812690-9	2021	Mechanistically, bergamottin blocked LPS-induced activation of NF-kappaB signaling in lung tissues.	bergamottin	17-28	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
34812690-10	2021	Additionally, bergamottin treatment reduced NF-kappaB p65 protein acetylation, which was coupled with induction of SIRT1 expression.	bergamottin	14-25	sirtuin 1	Mus musculus	115-120
34812690-12	2021	Induction of SIRT1 and inhibition of NF-kappaB underlies the anti-inflammatory activity of bergamottin.	bergamottin	91-102	sirtuin 1	Mus musculus	13-18
34812690-12	2021	Induction of SIRT1 and inhibition of NF-kappaB underlies the anti-inflammatory activity of bergamottin.	bergamottin	91-102	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	37-46
34168462-0	2021	Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis.	bergamottin	0-11	microRNA 145	Homo sapiens	92-99
34168462-0	2021	Bergamottin Induces DNA Damage and Inhibits Malignant Progression in Melanoma by Modulating miR-145/Cyclin D1 Axis.	bergamottin	0-11	cyclin D1	Homo sapiens	100-109
34168462-13	2021	Conclusion: Thus, we conclude that BGM induces DNA damage and inhibits tumor progression in melanoma by modulating the miR-145/Cyclin D1 axis.	bergamottin	35-38	microRNA 145	Homo sapiens	119-126
34168462-13	2021	Conclusion: Thus, we conclude that BGM induces DNA damage and inhibits tumor progression in melanoma by modulating the miR-145/Cyclin D1 axis.	bergamottin	35-38	cyclin D1	Homo sapiens	127-136
31317804-8	2020	These findings were supported by the result that the kobs (0.00000118 min-1) of bergamottin for CYP3A was lower than the kdeg (0.0005 min-1) for CYP3A.	bergamottin	80-91	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	96-101
35458667-7	2022	Among the screened compounds, Bergamottin, a furocoumarin, showed selective hMAO-B inhibitory activity, fitting its active site well.	bergamottin	30-41	monoamine oxidase B	Homo sapiens	76-82
32664320-4	2020	Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibitor of the principal human metabolizing enzyme, cytochrome P450 3A4 (CYP3A4).	bergamottin	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	128-147
32664320-4	2020	Bergamottin is a furanocoumarin found in citrus plants, which is a strong inhibitor of the principal human metabolizing enzyme, cytochrome P450 3A4 (CYP3A4).	bergamottin	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	149-155
31317804-0	2020	Bergamottin can be used to assess CYP3A-mediated intestinal first-pass metabolism without affecting P-glycoprotein-mediated efflux in rats.	bergamottin	0-11	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	34-39
35188515-0	2022	Bergamottin promotes osteoblast differentiation and bone formation via activating the Wnt/beta-catenin signaling pathway.	bergamottin	0-11	catenin beta 1	Homo sapiens	90-102
31317804-2	2020	We investigated whether bergamottin would be useful for evaluating CYP3A-mediated intestinal metabolism in rats utilising its characteristics as a mechanism-based inhibitor of CYP3A.2.	bergamottin	24-35	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	67-72
31317804-8	2020	These findings were supported by the result that the kobs (0.00000118 min-1) of bergamottin for CYP3A was lower than the kdeg (0.0005 min-1) for CYP3A.	bergamottin	80-91	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	145-150
31317804-10	2020	These profiles of bergamottin enable the convenient assessment of CYP3A-mediated intestinal metabolism.	bergamottin	18-29	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	66-71
31317804-2	2020	We investigated whether bergamottin would be useful for evaluating CYP3A-mediated intestinal metabolism in rats utilising its characteristics as a mechanism-based inhibitor of CYP3A.2.	bergamottin	24-35	cytochrome P450, family 3, subfamily a, polypeptide 2	Rattus norvegicus	176-183
31317804-4	2020	The effect of bergamottin pre-treatment on hepatic CYP3A specifically was investigated with intravenous administration of buspirone.	bergamottin	14-25	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	51-56
31317804-6	2020	Co-administration of bergamottin significantly increased the AUC0-inf for buspirone and fexofenadine by 1.6-fold and 1.7-fold, respectively, indicating that bergamottin inhibited both CYP3A and P-gp.4.	bergamottin	21-32	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	184-189
31317804-6	2020	Co-administration of bergamottin significantly increased the AUC0-inf for buspirone and fexofenadine by 1.6-fold and 1.7-fold, respectively, indicating that bergamottin inhibited both CYP3A and P-gp.4.	bergamottin	157-168	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	184-189
30254074-0	2018	Structures of human cytochrome P450 1A1 with bergamottin and erlotinib reveal active-site modifications for binding of diverse ligands.	bergamottin	45-56	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	20-39
31941150-0	2020	Synthesis of Spin-Labelled Bergamottin: A Potent CYP3A4 Inhibitor with Antiproliferative Activity.	bergamottin	27-38	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	49-55
31941150-1	2020	Bergamottin (BM, 1), a component of grapefruit juice, acts as an inhibitor of some isoforms of the cytochrome P450 (CYP) enzyme, particularly CYP3A4.	bergamottin	0-11	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-148
31941150-1	2020	Bergamottin (BM, 1), a component of grapefruit juice, acts as an inhibitor of some isoforms of the cytochrome P450 (CYP) enzyme, particularly CYP3A4.	bergamottin	13-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	142-148
31941150-2	2020	Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized; chemically characterized, evaluated as a potential inhibitor of the CYP2C19, CYP3A4, and CYP2C9 enzymes; and compared to BM and known inhibitors such as ketoconazole (KET) (3A4), warfarin (WAR) (2C9), and ticlopidine (TIC) (2C19).	bergamottin	14-25	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	169-176
31941150-2	2020	Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized; chemically characterized, evaluated as a potential inhibitor of the CYP2C19, CYP3A4, and CYP2C9 enzymes; and compared to BM and known inhibitors such as ketoconazole (KET) (3A4), warfarin (WAR) (2C9), and ticlopidine (TIC) (2C19).	bergamottin	14-25	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	178-184
31941150-2	2020	Herein, a new bergamottin containing a nitroxide moiety (SL-bergamottin, SL-BM, 10) was synthesized; chemically characterized, evaluated as a potential inhibitor of the CYP2C19, CYP3A4, and CYP2C9 enzymes; and compared to BM and known inhibitors such as ketoconazole (KET) (3A4), warfarin (WAR) (2C9), and ticlopidine (TIC) (2C19).	bergamottin	14-25	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	190-196
29435067-4	2018	A Rac1-GTP pull-down assay demonstrated that bergamottin-treated glioma cells had a significantly decreased level of active Rac1-GTP compared with untreated cells (P<0.05).	bergamottin	45-56	Rac family small GTPase 1	Homo sapiens	2-6
29435067-4	2018	A Rac1-GTP pull-down assay demonstrated that bergamottin-treated glioma cells had a significantly decreased level of active Rac1-GTP compared with untreated cells (P<0.05).	bergamottin	45-56	Rac family small GTPase 1	Homo sapiens	124-128
29435067-0	2018	Bergamottin, a natural furanocoumarin abundantly present in grapefruit juice, suppresses the invasiveness of human glioma cells via inactivation of Rac1 signaling.	bergamottin	0-11	Rac family small GTPase 1	Homo sapiens	148-152
29435067-6	2018	Expression of constitutively activated Rac1 almost completely restored the migration and invasion of bergamottin-treated glioma cells.	bergamottin	101-112	Rac family small GTPase 1	Homo sapiens	39-43
29435067-3	2018	Bergamottin treatment caused a significant decrease in the expression and secretion of matrix metalloproteinase (MMP)-9 in glioma cells compared with untreated cells (P<0.05).	bergamottin	0-11	matrix metallopeptidase 9	Homo sapiens	87-119
29435067-7	2018	In addition, bergamottin-induced downregulation of MMP-9 was prevented by exogenous activated Rac1.	bergamottin	13-24	matrix metallopeptidase 9	Homo sapiens	51-56
29435067-7	2018	In addition, bergamottin-induced downregulation of MMP-9 was prevented by exogenous activated Rac1.	bergamottin	13-24	Rac family small GTPase 1	Homo sapiens	94-98
29435067-8	2018	The results of the present study demonstrated that bergamottin exhibits anti-invasive activity in human glioma cells through the inactivation of Rac1 and downregulation of MMP-9.	bergamottin	51-62	Rac family small GTPase 1	Homo sapiens	145-149
29435067-8	2018	The results of the present study demonstrated that bergamottin exhibits anti-invasive activity in human glioma cells through the inactivation of Rac1 and downregulation of MMP-9.	bergamottin	51-62	matrix metallopeptidase 9	Homo sapiens	172-177