PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32300978-0	2020	Luminescent Coordination Polymer for Picric Acid Detection and Treatment on Spinal Cord Injury Model Via Upregulating the trka Expression.	picric acid	37-48	neurotrophic receptor tyrosine kinase 1	Homo sapiens	122-126
31948581-5	2020	The results of the TNP assay show that the composite fluorescent probe exhibits two wide linear regions in the range of 1-8 and 10-70 muM with a low limit detection of 0.17 muM, which is lower than that of free CDs for TNP (0.3 muM).	picric acid	19-22	latexin	Homo sapiens	134-137
32385658-0	2020	Zn(II)-Based Coordination Polymer for Detection of Picric Acid in Aqueous Media and Treatment Effect against Deep Vein Thrombosis by Reducing P-ERK2 and p53 Expression.	picric acid	51-62	mitogen-activated protein kinase 1	Homo sapiens	144-148
32385658-0	2020	Zn(II)-Based Coordination Polymer for Detection of Picric Acid in Aqueous Media and Treatment Effect against Deep Vein Thrombosis by Reducing P-ERK2 and p53 Expression.	picric acid	51-62	tumor protein p53	Homo sapiens	153-156
31945433-1	2020	We report here on the green synthesis method of hydrogel nanocomposite (Na-Ala/Chit-cl-polyAAm/CQDs) incorporated with carbon quantum dots for picric acid sensing and biebrich scharlet dye removal from industrial waste water.	picric acid	143-154	chitinase 1	Homo sapiens	79-83
31771909-0	2020	A mechanical stability enhanced luminescence lanthanide MOF test strip encapsulated with polymer net for detecting picric acid and macrodantin.	picric acid	115-126	lysine acetyltransferase 8	Homo sapiens	56-59
31948581-5	2020	The results of the TNP assay show that the composite fluorescent probe exhibits two wide linear regions in the range of 1-8 and 10-70 muM with a low limit detection of 0.17 muM, which is lower than that of free CDs for TNP (0.3 muM).	picric acid	19-22	latexin	Homo sapiens	173-176
31948581-5	2020	The results of the TNP assay show that the composite fluorescent probe exhibits two wide linear regions in the range of 1-8 and 10-70 muM with a low limit detection of 0.17 muM, which is lower than that of free CDs for TNP (0.3 muM).	picric acid	19-22	latexin	Homo sapiens	173-176
31948581-5	2020	The results of the TNP assay show that the composite fluorescent probe exhibits two wide linear regions in the range of 1-8 and 10-70 muM with a low limit detection of 0.17 muM, which is lower than that of free CDs for TNP (0.3 muM).	picric acid	219-222	latexin	Homo sapiens	134-137
31948581-5	2020	The results of the TNP assay show that the composite fluorescent probe exhibits two wide linear regions in the range of 1-8 and 10-70 muM with a low limit detection of 0.17 muM, which is lower than that of free CDs for TNP (0.3 muM).	picric acid	219-222	latexin	Homo sapiens	173-176
31948581-5	2020	The results of the TNP assay show that the composite fluorescent probe exhibits two wide linear regions in the range of 1-8 and 10-70 muM with a low limit detection of 0.17 muM, which is lower than that of free CDs for TNP (0.3 muM).	picric acid	219-222	latexin	Homo sapiens	173-176
30249931-5	2019	Based on an inner filter effect between PA and P-CDs, a linear response is obtained for PA from 0.1 to 10 muM with a detection limit of 82 nM.	picric acid	40-42	latexin	Homo sapiens	106-109
30903871-0	2019	CdS QDs/N-methylpolypyrrole hybrids as fluorescent probe for ultrasensitive and selective detection of picric acid.	picric acid	103-114	CDP-diacylglycerol synthase 1	Homo sapiens	0-3
30903871-8	2019	Further studies unveiled that the emission of CdS QDs/NMPPY hybrid is strongly and selectively quenched by picric acid molecule with a large Stern-Volmer constant of 843,900 M-1 and an excellent detection limit of 4.6 x 10-7 M. The changes in the UV-vis spectra of picric acid solutions in the presence and absence of CdS QDs/NMPPY hybrid displayed that the fluorescence quenching occurs through a static quenching mechanism.	picric acid	107-118	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
30903871-8	2019	Further studies unveiled that the emission of CdS QDs/NMPPY hybrid is strongly and selectively quenched by picric acid molecule with a large Stern-Volmer constant of 843,900 M-1 and an excellent detection limit of 4.6 x 10-7 M. The changes in the UV-vis spectra of picric acid solutions in the presence and absence of CdS QDs/NMPPY hybrid displayed that the fluorescence quenching occurs through a static quenching mechanism.	picric acid	107-118	CDP-diacylglycerol synthase 1	Homo sapiens	318-321
30903871-8	2019	Further studies unveiled that the emission of CdS QDs/NMPPY hybrid is strongly and selectively quenched by picric acid molecule with a large Stern-Volmer constant of 843,900 M-1 and an excellent detection limit of 4.6 x 10-7 M. The changes in the UV-vis spectra of picric acid solutions in the presence and absence of CdS QDs/NMPPY hybrid displayed that the fluorescence quenching occurs through a static quenching mechanism.	picric acid	265-276	CDP-diacylglycerol synthase 1	Homo sapiens	46-49
30903871-8	2019	Further studies unveiled that the emission of CdS QDs/NMPPY hybrid is strongly and selectively quenched by picric acid molecule with a large Stern-Volmer constant of 843,900 M-1 and an excellent detection limit of 4.6 x 10-7 M. The changes in the UV-vis spectra of picric acid solutions in the presence and absence of CdS QDs/NMPPY hybrid displayed that the fluorescence quenching occurs through a static quenching mechanism.	picric acid	265-276	CDP-diacylglycerol synthase 1	Homo sapiens	318-321
30903871-9	2019	Finally, the proposed CdS QDs/NMPPY sensor was successfully utilized to determine the amount of picric acid in real water samples.	picric acid	96-107	CDP-diacylglycerol synthase 1	Homo sapiens	22-25
31594608-3	2020	The detection range is observed to be 0.1-120 muM of PA (22.9 ppb-27.5 ppm).	picric acid	53-55	latexin	Homo sapiens	46-49
31272039-4	2019	When the PA concentration ranged from 2.0 to 180 ng mL-1, the concentration was linearly related to the quenching intensity of the QDs, with a detection limit of 1.4 ng mL-1.	picric acid	9-11	L1 cell adhesion molecule	Mus musculus	52-56
31272039-4	2019	When the PA concentration ranged from 2.0 to 180 ng mL-1, the concentration was linearly related to the quenching intensity of the QDs, with a detection limit of 1.4 ng mL-1.	picric acid	9-11	L1 cell adhesion molecule	Mus musculus	169-173
30249931-5	2019	Based on an inner filter effect between PA and P-CDs, a linear response is obtained for PA from 0.1 to 10 muM with a detection limit of 82 nM.	picric acid	88-90	latexin	Homo sapiens	106-109
29842835-3	2018	Only one IP6K inhibitor is commonly used: N2-( m-(trifluoromethyl)benzyl) N6-( p-nitrobenzyl)purine (TNP).	picric acid	101-104	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	9-13
31459392-3	2019	The selectivity of L 1 toward PA has been demonstrated on the basis of fluorescence and absorption spectroscopy, and the species of recognition by electrospray ionization mass spectrometry.	picric acid	30-32	L1 cell adhesion molecule	Homo sapiens	19-22
31459392-6	2019	L 1 was demonstrated to detect PA in solid state selectively over other nitroaromatic compounds (NACs).	picric acid	31-33	L1 cell adhesion molecule	Homo sapiens	0-3
31459392-7	2019	To study the utility of L 1 in film, cellulose paper strips coated with L 1 were used and demonstrated the selective detection of PA.	picric acid	130-132	L1 cell adhesion molecule	Homo sapiens	24-27
31459392-7	2019	To study the utility of L 1 in film, cellulose paper strips coated with L 1 were used and demonstrated the selective detection of PA.	picric acid	130-132	L1 cell adhesion molecule	Homo sapiens	72-75
31459392-9	2019	Thus, L 1 was demonstrated as a sensitive, selective, and inexpensive probe for PA over several NACs by visual, spectral, and microscopy methods.	picric acid	80-82	L1 cell adhesion molecule	Homo sapiens	6-9
30338341-3	2018	Fluorescence drops with increasing concentration of PA which can be detected fluorometrically with a 0.14 muM limit of detection.	picric acid	52-54	latexin	Homo sapiens	106-109
30656313-0	2019	Pseudo five component reaction towards densely functionalized spiro[indole-3,2"-pyrrole] by picric acid, an efficient syn-diastereoselective catalyst: insight into the diastereoselection on C(sp3)-C(sp3) axial conformation.	picric acid	92-103	synemin	Homo sapiens	118-121
30267977-2	2019	The color change and quenching of the dye emission are selective detections of picric acid at nanomolar concentration is accomplished in water medium without having any interference from other NAC"s.	picric acid	79-90	X-linked Kx blood group	Homo sapiens	193-196
31458956-2	2018	These were demonstrated as efficient SERS substrates for the detection of multiple explosive molecules such as picric acid (5 muM), 2,4-dinitrotoluene (1 muM), and 3-nitro-1,2,4-triazol-5-one (10 muM) along with a common dye molecule (methylene blue, 5 nM).	picric acid	111-122	latexin	Homo sapiens	126-129
29913243-6	2018	Intrathecal injection of the P2X3/4 inhibitor TNP-ATP blocked the initial response to IL-6r in both males and females, but only blocked hyperalgesic priming in male mice.	picric acid	46-49	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	29-35
29913243-6	2018	Intrathecal injection of the P2X3/4 inhibitor TNP-ATP blocked the initial response to IL-6r in both males and females, but only blocked hyperalgesic priming in male mice.	picric acid	46-49	interleukin 6 receptor, alpha	Mus musculus	86-91
28682050-0	2017	Dual-Emitting Dye@MOF Composite as a Self-Calibrating Sensor for 2,4,6-Trinitrophenol.	picric acid	65-85	lysine acetyltransferase 8	Homo sapiens	18-21
29869157-7	2018	Response is linear in the 0.2 to 10 muM TNP concentration range, with a 0.1 muM detection limit (at S/N = 3) and a 15.98 muA muM-1 cm-2 sensitivity under optimal conditions.	picric acid	40-43	PWWP domain containing 3A, DNA repair factor	Homo sapiens	125-130
29145072-6	2018	The high selectivity exhibited by the nano-assembly allows to detect PA in real samples like tap water, river water and matchstick.	picric acid	69-71	nuclear RNA export factor 1	Homo sapiens	93-96
29145072-7	2018	Advantageously, the nano-assembly PM-GSH-CuNCs was chemically adsorbed over the cellulosic strips and applied for the naked-eye detection of PA down to 1muM.	picric acid	141-143	latexin	Homo sapiens	153-156
29448655-4	2018	This photoluminescent probe exhibits excellent sensitivity and selectivity toward PA from 0.4 muM to 80 muM with correlation coefficient (r) of 0.9987.	picric acid	82-84	latexin	Homo sapiens	94-97
29448655-4	2018	This photoluminescent probe exhibits excellent sensitivity and selectivity toward PA from 0.4 muM to 80 muM with correlation coefficient (r) of 0.9987.	picric acid	82-84	latexin	Homo sapiens	104-107
29448655-6	2018	Furthermore, the proposed C-dots for photoluminescent probe detection of PA in real water samples (river water, refinery wastewater and pharmaceutical factory wastewater) by adding 5 muM and 20 muM PA with satisfactory recoveries from 99.5% to 101.5%.	picric acid	73-75	latexin	Homo sapiens	183-186
29448655-6	2018	Furthermore, the proposed C-dots for photoluminescent probe detection of PA in real water samples (river water, refinery wastewater and pharmaceutical factory wastewater) by adding 5 muM and 20 muM PA with satisfactory recoveries from 99.5% to 101.5%.	picric acid	73-75	latexin	Homo sapiens	194-197
28792058-3	2017	This system displayed a higher beta2 value of 1.7 x 108 M-2 and was able to detect PA down to 1.12 ppm (4.99 muM).	picric acid	83-85	latexin	Homo sapiens	109-112
29618559-4	2018	We report that disrupting the inositol hexakisphosphate kinase 1 (Ip6k1) gene or pharmacologically inhibiting IP6K1 activity using the specific inhibitor TNP [N2-(m-(trifluoromethyl)benzyl) N6-(p-nitrobenzyl)purine] efficiently and effectively enhanced host bacterial killing but reduced pulmonary neutrophil accumulation, minimizing the lung damage caused by both Gram-positive and Gram-negative bacterial pneumonia.	picric acid	154-157	inositol hexakisphosphate kinase 1	Homo sapiens	66-71
29618559-4	2018	We report that disrupting the inositol hexakisphosphate kinase 1 (Ip6k1) gene or pharmacologically inhibiting IP6K1 activity using the specific inhibitor TNP [N2-(m-(trifluoromethyl)benzyl) N6-(p-nitrobenzyl)purine] efficiently and effectively enhanced host bacterial killing but reduced pulmonary neutrophil accumulation, minimizing the lung damage caused by both Gram-positive and Gram-negative bacterial pneumonia.	picric acid	154-157	inositol hexakisphosphate kinase 1	Homo sapiens	110-115
29533608-6	2018	Por-MOFs 1-3 can be employed as chemosensors because of a measured fluorescence quenching up to 70% for nitrobenzene, 1,4-dinitrobenzene, 4-nitrophenol, and phenol, with 2,4,6-trinitrophenol exhibiting a peculiar fluorescence profile.	picric acid	170-190	cytochrome p450 oxidoreductase	Homo sapiens	0-3
29456508-6	2018	In 2016, crystal structures of human P2X3 in complex with the competitive antagonists TNP-ATP and A-317491, and Ailuropoda melanoleuca P2X7 in complex with a series of allosteric antagonists were published, giving fascinating insights into the mechanism of channel antagonism.	picric acid	86-89	purinergic receptor P2X 3	Homo sapiens	37-41
29434105-1	2018	The solvent-extraction behavior of Li+ and Na+ with a Li+ selective metallacrown, [{Ru(eta6-3,5-dimethylanisole)(2,3-pyridinediolate)}3], was investigated in the presence of organic dye anions, 3",3"",5",5""-tetrabromophenolphthalein ethyl ester ([TBPE]-), 2,6-dichloroindophenolate, and picrate ([pic]-).	picric acid	288-295	endothelin receptor type A	Homo sapiens	69-72
28682050-2	2017	As a result, the obtained dye@MOF composite system features a blue emission of the ligand at 373 nm and a red emission of Rh6G at 570 nm when dispersed in solution, which could be used for decoding the trace amount of 2,4,6-trinitrophenol (TNP) by referring the peak-height ratio of each emission, even in coexistence with other potentially competitive nitroaromatic analytes.	picric acid	218-238	lysine acetyltransferase 8	Homo sapiens	30-33
28682050-2	2017	As a result, the obtained dye@MOF composite system features a blue emission of the ligand at 373 nm and a red emission of Rh6G at 570 nm when dispersed in solution, which could be used for decoding the trace amount of 2,4,6-trinitrophenol (TNP) by referring the peak-height ratio of each emission, even in coexistence with other potentially competitive nitroaromatic analytes.	picric acid	240-243	lysine acetyltransferase 8	Homo sapiens	30-33
31457676-3	2017	Py-azo-COP shows selective sensing toward the electron-deficient polynitroaromatic compound picric acid among the many other competing analogs that were investigated.	picric acid	92-103	caspase recruitment domain family member 16	Homo sapiens	7-10
28340788-6	2017	The reliability of NI-MFGDP-MS was characterized by the analysis of a picric acid-RDX-PETN mixture and a mixture of RDX-pond water.	picric acid	70-81	radixin	Homo sapiens	82-85
28094504-2	2017	1 presents a 2-fold interpenetrating network along with confined narrow channels and rich acylamide groups as well as potential metal open sites for excellent selective CO2 uptake over CH4/N2 and high luminescent response for 2,4,6-trinitrophenol (TNP) in DMA solution under ambient conditions.	picric acid	248-251	chimerin 2	Homo sapiens	185-191
28154132-10	2017	Pharmacologic inhibition of IP6K by TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] recapitulates the phenotype of IP6K1 deletion.	picric acid	36-39	diphosphoinositol pentakisphosphate kinase 1	Homo sapiens	28-32
28154132-10	2017	Pharmacologic inhibition of IP6K by TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] recapitulates the phenotype of IP6K1 deletion.	picric acid	36-39	inositol hexakisphosphate kinase 1	Homo sapiens	122-127
27689003-0	2016	TNP [N2-(m-Trifluorobenzyl), N6-(p-nitrobenzyl)purine] ameliorates diet induced obesity and insulin resistance via inhibition of the IP6K1 pathway.	picric acid	0-3	inositol hexaphosphate kinase 1	Mus musculus	133-138
27682429-1	2016	Addition of 2,4,6-trinitrophenol (HTNP) to an ethene-bridged diiron(III) mu-oxo bisporphyrin (1) in CH2 Cl2 initially leads to the formation of diiron(III) mu-hydroxo bisporphyrin (2 TNP) with a phenolate counterion that, after further addition of HTNP or dissolution in a nonpolar solvent, converts to a diiron(III) complex with axial phenoxide coordination (3 (TNP)2 ).	picric acid	12-32	transition protein 2	Homo sapiens	363-368
27171212-2	2016	The diamagnetic complex shows a highly intense AIE induced by NEt3H(+), which disappears after picric acid recognition and subsequently RET will quench the emission intensity.	picric acid	95-106	ret proto-oncogene	Homo sapiens	136-139
27090616-6	2016	Interestingly, these MOFs represent excellent fluorescent properties, which can be efficiently quenched by trace amounts of nitrofurazone (NZF) and nitrofurantoin (NFT) antibiotics as well as 2,4,6-trinitrophenol (TNP) and 4-nitrophenol (4-NP) organic explosives in water solution.	picric acid	214-217	PHD finger protein 20	Homo sapiens	139-142
26030223-4	2015	The Stern-Volmer (S-V) plot for Py excimer fluorescence quenching by PA shows two linear regions at low (0-1 muM) and high concentration range (>1 muM) with a quenching constant of 1.263 x 10(6) M(-1) and 5.08 x 10(4) M(-1), respectively.	picric acid	69-71	latexin	Homo sapiens	109-112
26585348-1	2016	Water soluble perylenediimide based fluorophore salt, N,N"-bis(ethelenetrimethyl ammoniumiodide)-perylene-3,4,9,10-tetracarboxylicbisimide (PDI-1), has been used for selective fluorescence sensing of picric acid (PA) and 4-nitroaniline (4-NA) in organic as well as aqueous medium across wide pH range (1.0 to 10.0).	picric acid	200-211	peptidyl arginine deiminase 1	Homo sapiens	140-145
26585348-1	2016	Water soluble perylenediimide based fluorophore salt, N,N"-bis(ethelenetrimethyl ammoniumiodide)-perylene-3,4,9,10-tetracarboxylicbisimide (PDI-1), has been used for selective fluorescence sensing of picric acid (PA) and 4-nitroaniline (4-NA) in organic as well as aqueous medium across wide pH range (1.0 to 10.0).	picric acid	213-215	peptidyl arginine deiminase 1	Homo sapiens	140-145
26592546-8	2015	For DPTB-MPS, the addition of 80 muM nitrobenzene, 60 muM m-nitrobenzene and 40 muM PA resulted in about 50% quenching in aqueous solutions.	picric acid	84-86	latexin	Homo sapiens	33-36
26585348-3	2016	Addition of picric acid (PA) and 4-nitroaniline (4-NA) into PDI-1 in DMF/aqueous solution selectively quenches the fluorescence.	picric acid	12-23	peptidyl arginine deiminase 1	Homo sapiens	60-65
26585348-3	2016	Addition of picric acid (PA) and 4-nitroaniline (4-NA) into PDI-1 in DMF/aqueous solution selectively quenches the fluorescence.	picric acid	25-27	peptidyl arginine deiminase 1	Homo sapiens	60-65
26585348-6	2016	Interestingly, PDI-1 showed selective fluorescence sensing of PA and 4-NA across wide pH range (1.0 to 10.0).	picric acid	62-64	peptidyl arginine deiminase 1	Homo sapiens	15-20
26585348-7	2016	Selective fluorescence sensing of PA and 4-NA has also been observed with trifluoroacetate (PDI-2), sulfate (PDI-3) salt of PDI-1 as well as octyl chain substituted PDI (PDI-4) without amine functionality.	picric acid	34-36	peptidyl arginine deiminase 2	Homo sapiens	92-97
26585348-7	2016	Selective fluorescence sensing of PA and 4-NA has also been observed with trifluoroacetate (PDI-2), sulfate (PDI-3) salt of PDI-1 as well as octyl chain substituted PDI (PDI-4) without amine functionality.	picric acid	34-36	peptidyl arginine deiminase 3	Homo sapiens	109-114
26585348-7	2016	Selective fluorescence sensing of PA and 4-NA has also been observed with trifluoroacetate (PDI-2), sulfate (PDI-3) salt of PDI-1 as well as octyl chain substituted PDI (PDI-4) without amine functionality.	picric acid	34-36	peptidyl arginine deiminase 1	Homo sapiens	124-129
26585348-7	2016	Selective fluorescence sensing of PA and 4-NA has also been observed with trifluoroacetate (PDI-2), sulfate (PDI-3) salt of PDI-1 as well as octyl chain substituted PDI (PDI-4) without amine functionality.	picric acid	34-36	peptidyl arginine deiminase 4	Homo sapiens	92-95
26585348-7	2016	Selective fluorescence sensing of PA and 4-NA has also been observed with trifluoroacetate (PDI-2), sulfate (PDI-3) salt of PDI-1 as well as octyl chain substituted PDI (PDI-4) without amine functionality.	picric acid	34-36	peptidyl arginine deiminase 4	Homo sapiens	170-175
26585348-8	2016	These studies suggest that PA and 4-NA might be having preferential interaction with PDI aromatic core and quenches the fluorescence.	picric acid	27-29	peptidyl arginine deiminase 4	Homo sapiens	85-88
26011558-5	2015	Traf3ip3 KO mice also exhibited a reduced amount of serum natural antibodies and impaired T cell-independent type II (TI-II) responses to trinitrophenol (TNP)-Ficoll antigen.	picric acid	138-152	TRAF3 interacting protein 3	Mus musculus	0-8
26030223-4	2015	The Stern-Volmer (S-V) plot for Py excimer fluorescence quenching by PA shows two linear regions at low (0-1 muM) and high concentration range (>1 muM) with a quenching constant of 1.263 x 10(6) M(-1) and 5.08 x 10(4) M(-1), respectively.	picric acid	69-71	latexin	Homo sapiens	150-153
25305621-1	2015	Herein, this study was focused to get a knowledge about the intermolecular charge transfer complexes between the second generation of poly(propylene amine) dendrimer (PPD2) with picric acid (PA) and iodine (I2) as pi and sigma-acceptors.	picric acid	178-189	limb development membrane protein 1	Homo sapiens	167-171
25305621-1	2015	Herein, this study was focused to get a knowledge about the intermolecular charge transfer complexes between the second generation of poly(propylene amine) dendrimer (PPD2) with picric acid (PA) and iodine (I2) as pi and sigma-acceptors.	picric acid	191-193	limb development membrane protein 1	Homo sapiens	167-171
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	picric acid	179-181	calcium binding protein, spermatid associated 1	Homo sapiens	255-259
25531209-3	2015	For validation of the proposed approach, 2,4,6-trinitrophenol (TNP) is used as the reporter for specific detection of phospholipase A2 (PLA2), a key enzyme in various membrane related physiological processes.	picric acid	41-61	phospholipase A2 group IB	Homo sapiens	118-134
25531209-3	2015	For validation of the proposed approach, 2,4,6-trinitrophenol (TNP) is used as the reporter for specific detection of phospholipase A2 (PLA2), a key enzyme in various membrane related physiological processes.	picric acid	41-61	phospholipase A2 group IB	Homo sapiens	136-140
25531209-3	2015	For validation of the proposed approach, 2,4,6-trinitrophenol (TNP) is used as the reporter for specific detection of phospholipase A2 (PLA2), a key enzyme in various membrane related physiological processes.	picric acid	63-66	phospholipase A2 group IB	Homo sapiens	118-134
25531209-3	2015	For validation of the proposed approach, 2,4,6-trinitrophenol (TNP) is used as the reporter for specific detection of phospholipase A2 (PLA2), a key enzyme in various membrane related physiological processes.	picric acid	63-66	phospholipase A2 group IB	Homo sapiens	136-140
25515515-6	2015	Also modification of the natural ligand ATP led to the discovery of P2X receptor antagonists like TNP-ATP (29), which, although not selective, showed high potency at P2X1, P2X3 (IC50 of 0.006 microM and 0.001 microM, respectively), and heteromeric P2X2/3 receptors.	picric acid	98-101	purinergic receptor P2X 1	Homo sapiens	166-170
25515515-6	2015	Also modification of the natural ligand ATP led to the discovery of P2X receptor antagonists like TNP-ATP (29), which, although not selective, showed high potency at P2X1, P2X3 (IC50 of 0.006 microM and 0.001 microM, respectively), and heteromeric P2X2/3 receptors.	picric acid	98-101	purinergic receptor P2X 3	Homo sapiens	172-176
25319016-5	2014	Moreover, it was found for the first time that the macrocycles could selectively recognize nitroaromatics explosives bearing methyl group through a CH3-pi interactions, and even exhibit a sole selectivity for TNT among the very difficultly differentiating nitroaromatics including trinitrophenol and trinitrobenzene.	picric acid	281-295	chromosome 16 open reading frame 82	Homo sapiens	209-212
24515606-1	2014	A ratiometric fluorescent probe based on dual luminescence QD/CPL for selective sensing of the nitroaromatic explosive picric acid (PA) was constructed.	picric acid	119-130	hephaestin	Homo sapiens	62-65
24515606-1	2014	A ratiometric fluorescent probe based on dual luminescence QD/CPL for selective sensing of the nitroaromatic explosive picric acid (PA) was constructed.	picric acid	132-134	hephaestin	Homo sapiens	62-65
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	picric acid	251-253	calcium binding protein, spermatid associated 1	Homo sapiens	183-187
23624039-3	2013	A buffer solution had been used and the extraction was carried out using organic solvent, the ion associates exhibit absorption maxima at 410, 410, 430 and 530 nm of (Br-HCl)with PA, CLPH, AR and Rk respectively; 410, 410, 435 and 530 of (E-HCl) with PA, CLPH, AR and Rk respectively.	picric acid	251-253	calcium binding protein, spermatid associated 1	Homo sapiens	255-259
23692257-0	2013	Attogram detection of picric acid by hexa-peri-hexabenzocoronene-based chemosensors by controlled aggregation-induced emission enhancement.	picric acid	22-33	hexosaminidase subunit alpha	Homo sapiens	37-41
23428419-8	2013	Further, we found that ATP-induced IL-1beta and IL-18 release from LPS-primed BMDCs was suppressed by pretreatment with P2X7 antagonist A438079 or P2X4 antagonist TNP-ATP.	picric acid	163-166	interleukin 1 beta	Mus musculus	35-43
23428419-8	2013	Further, we found that ATP-induced IL-1beta and IL-18 release from LPS-primed BMDCs was suppressed by pretreatment with P2X7 antagonist A438079 or P2X4 antagonist TNP-ATP.	picric acid	163-166	interleukin 18	Mus musculus	48-53
23428419-8	2013	Further, we found that ATP-induced IL-1beta and IL-18 release from LPS-primed BMDCs was suppressed by pretreatment with P2X7 antagonist A438079 or P2X4 antagonist TNP-ATP.	picric acid	163-166	purinergic receptor P2X, ligand-gated ion channel 4	Mus musculus	147-151
22508391-3	2012	Interestingly, COP-3 and COP-4 show very fast responses and high sensitivity to the nitroaromatic explosives, and also high selectivity for tracing picric acid (PA) and 2,4,6-trinitrotoluene (TNT) at low concentration (<1 ppm).	picric acid	148-159	caspase recruitment domain family member 16	Homo sapiens	15-18
23044918-2	2012	Furthermore, under identical reaction conditions, using a Co(II) salt instead, a novel 3D framework material, trip-MOF-1, was isolated and its sensitivity towards picric acid was also evaluated.	picric acid	163-174	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	58-64
23865349-5	2013	RESULTS: Significant differences in the eGFR results estimated through enzymatic and picric acid methods were observed for the same evaluation equation.	picric acid	85-96	epidermal growth factor receptor	Homo sapiens	40-44
23865349-6	2013	The intraclass correlation coefficient (ICC) of eGFR when the creatinine was measured by the picric acid method was significantly lower than that of the enzymatic method.	picric acid	93-104	epidermal growth factor receptor	Homo sapiens	48-52
22508391-3	2012	Interestingly, COP-3 and COP-4 show very fast responses and high sensitivity to the nitroaromatic explosives, and also high selectivity for tracing picric acid (PA) and 2,4,6-trinitrotoluene (TNT) at low concentration (<1 ppm).	picric acid	148-159	caspase recruitment domain family member 16	Homo sapiens	25-28
22508391-3	2012	Interestingly, COP-3 and COP-4 show very fast responses and high sensitivity to the nitroaromatic explosives, and also high selectivity for tracing picric acid (PA) and 2,4,6-trinitrotoluene (TNT) at low concentration (<1 ppm).	picric acid	161-163	caspase recruitment domain family member 16	Homo sapiens	15-18
22508391-3	2012	Interestingly, COP-3 and COP-4 show very fast responses and high sensitivity to the nitroaromatic explosives, and also high selectivity for tracing picric acid (PA) and 2,4,6-trinitrotoluene (TNT) at low concentration (<1 ppm).	picric acid	161-163	caspase recruitment domain family member 16	Homo sapiens	25-28
22560174-5	2012	Remarkably, the as-synthesized SNW-1 nanoparticles exhibit extremely high sensitivity and selectivity, as well as fast response to nitroaromatic explosives such as 2,4,6-trinitrotoluene (TNT), 2,4,6-trinitrophenylmethylnitramine (Tetryl) and picric acid (PA) without interference by common organic solvents, which is due to the nanoscaled size and unique hierarchical porosity of such fluorescence-based sensing material.	picric acid	242-253	SNW domain containing 1	Homo sapiens	31-36
22560174-5	2012	Remarkably, the as-synthesized SNW-1 nanoparticles exhibit extremely high sensitivity and selectivity, as well as fast response to nitroaromatic explosives such as 2,4,6-trinitrotoluene (TNT), 2,4,6-trinitrophenylmethylnitramine (Tetryl) and picric acid (PA) without interference by common organic solvents, which is due to the nanoscaled size and unique hierarchical porosity of such fluorescence-based sensing material.	picric acid	255-257	SNW domain containing 1	Homo sapiens	31-36
22956138-6	2012	We here describe a fluorescent method using the ATP analog TNP-ATP that allows evaluating the allosteric conformational changes at the ATP-binding site of PDK1 triggered by small compounds binding to the PIF-pocket.	picric acid	59-62	pyruvate dehydrogenase kinase 1	Homo sapiens	155-159
22298493-5	2012	A superquenching effect was observed in the picric-acid-detection process by using nanosuspensions of hb-P1/2.	picric acid	44-55	HMG-box transcription factor 1	Homo sapiens	102-109
22956138-6	2012	We here describe a fluorescent method using the ATP analog TNP-ATP that allows evaluating the allosteric conformational changes at the ATP-binding site of PDK1 triggered by small compounds binding to the PIF-pocket.	picric acid	59-62	PIF1 5'-to-3' DNA helicase	Homo sapiens	204-207
20026672-6	2010	In this study, we compared the effects of five formaldehyde concentrations between 0.25% and 4.0% (w/v) and five picric acid concentrations between 0.0% and 0.8% (w/v) on the IR of GLS, the voltage-gated sodium channel 1.8 (Na(v)1.8), and the capsaicin receptor TRPV1.	picric acid	113-124	glutaminase	Rattus norvegicus	181-184
21915898-6	2011	The deshieldings on H-3a, H-5a and the ortho protons of the phenyl groups are less in the nitrate and picrate than in the corresponding hydrochloride.	picric acid	102-109	H3 clustered histone 1	Homo sapiens	20-24
20938337-7	2010	Moreover, the amount of immunoprecipitated postsynaptic density-95/NR1/NR2B complex was increased in morphine-tolerant rats, and this was prevented by the TNP-ATP treatment.	picric acid	155-158	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	67-70
20938337-7	2010	Moreover, the amount of immunoprecipitated postsynaptic density-95/NR1/NR2B complex was increased in morphine-tolerant rats, and this was prevented by the TNP-ATP treatment.	picric acid	155-158	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	71-75
21272050-5	2011	Further, the Tc1 DNFB CS-initiating component, like Th1 response to TNP-Cl, was elicited by only 1-day after immunization, due to B-1 cells.	picric acid	68-71	negative elongation factor complex member C/D, Th1l	Mus musculus	52-55
21908915-0	2011	Enhanced indirect fluorescence detection of p-nitrophenol, 2,4-dinitrophenol and trinitrophenol by micellar electrokinetic capillary chromatography with in-column optical-fiber LED-induced fluorescence detection.	picric acid	81-95	small integral membrane protein 10 like 2A	Homo sapiens	177-180
21908915-1	2011	Enhanced indirect fluorescence detection with in-column optical-fiber LED-induced fluorescence (LED-IF) detection has been developed for the simultaneous separation and determination of p-nitrophenol, 2,4-dinitrophenol and trinitrophenol.	picric acid	223-237	small integral membrane protein 10 like 2A	Homo sapiens	70-73
21908915-1	2011	Enhanced indirect fluorescence detection with in-column optical-fiber LED-induced fluorescence (LED-IF) detection has been developed for the simultaneous separation and determination of p-nitrophenol, 2,4-dinitrophenol and trinitrophenol.	picric acid	223-237	small integral membrane protein 10 like 2A	Homo sapiens	96-99
19443836-4	2009	In HEK293 cells expressing TRPC6, application of mechanical stimuli (hypotonicity, shear, 2,4,6-trinitrophenol) caused, albeit not effective by themselves, a prominent potentiation of cationic currents (I(TRPC6)) induced by a muscarinic receptor agonist carbachol.	picric acid	90-110	transient receptor potential cation channel subfamily C member 6	Homo sapiens	27-32
20026672-8	2010	Lowering formaldehyde concentration elevated IR for all three antigens, while raising picric acid concentration increased Na(v)1.8 and TRPV1 IR.	picric acid	86-97	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	122-130
20026672-8	2010	Lowering formaldehyde concentration elevated IR for all three antigens, while raising picric acid concentration increased Na(v)1.8 and TRPV1 IR.	picric acid	86-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	135-140
19443836-4	2009	In HEK293 cells expressing TRPC6, application of mechanical stimuli (hypotonicity, shear, 2,4,6-trinitrophenol) caused, albeit not effective by themselves, a prominent potentiation of cationic currents (I(TRPC6)) induced by a muscarinic receptor agonist carbachol.	picric acid	90-110	transient receptor potential cation channel subfamily C member 6	Homo sapiens	205-210
19967073-4	2008	ATP-induced currents in TG neurons exhibited electrophysiological properties similar to those in HEK293 cells, and both ATP- and alpha ,beta-meATP-induced currents in TG neurons were effectively blocked by TNP-ATP, suggesting that P2X(3) mediates the majority of ATP-induced currents in TG neurons.	picric acid	206-209	ATPase phospholipid transporting 8A2	Homo sapiens	120-134
19425579-4	2009	The electropolymerization of the bis-aniline-cross-linked AuNPs composite in the presence of picric acid results in a molecular-imprinted matrix for the enhanced binding of TNT.	picric acid	93-104	chromosome 16 open reading frame 82	Homo sapiens	173-176
19427685-11	2009	TACI-/- mice had impaired IgM and IgG1 antibody responses to immunization, with a suboptimal dose of the type I T cell-independent antigen 2, 4, 6- Trinitrophenol (TNP)-LPS.	picric acid	139-162	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	0-4
19427685-11	2009	TACI-/- mice had impaired IgM and IgG1 antibody responses to immunization, with a suboptimal dose of the type I T cell-independent antigen 2, 4, 6- Trinitrophenol (TNP)-LPS.	picric acid	164-167	tumor necrosis factor receptor superfamily, member 13b	Mus musculus	0-4
19050295-4	2008	The relative nephritogenicity of anti-trinitrophenol switch variant mAbs was then explored and shown to be IgG2a > IgG2b, with no disease caused by IgG1.	picric acid	38-52	immunoglobulin heavy variable V1-9	Mus musculus	107-112
19050295-4	2008	The relative nephritogenicity of anti-trinitrophenol switch variant mAbs was then explored and shown to be IgG2a > IgG2b, with no disease caused by IgG1.	picric acid	38-52	immunoglobulin heavy constant gamma 2B	Mus musculus	118-123
19967073-4	2008	ATP-induced currents in TG neurons exhibited electrophysiological properties similar to those in HEK293 cells, and both ATP- and alpha ,beta-meATP-induced currents in TG neurons were effectively blocked by TNP-ATP, suggesting that P2X(3) mediates the majority of ATP-induced currents in TG neurons.	picric acid	206-209	purinergic receptor P2X 3	Homo sapiens	231-237
16199664-5	2005	This novel BFP/TNP-ATP FRET pair demonstrated efficient energy transfer as evidenced by appreciable BFP-donor quenching by bound TNP-ATP.	picric acid	15-18	ring finger protein 112	Homo sapiens	11-14
17567811-4	2007	N-Ethylmaleimide, (2-aminoethyl)-methane thiosulfonate, 2-aminoethoxydiphneyl borate, and trinitrophenol, compounds that are known to activate TRPA1, also failed to activate it in inside-out patches.	picric acid	90-104	transient receptor potential cation channel subfamily A member 1	Homo sapiens	143-148
18810995-1	2008	Nitroaromatic explosives like 2,4,6-trinitrotoluene (TNT) and 2,4,6-trinitrophenyl-N-methyl-nitramine (tetryl) comprise an important group of toxic environmental pollutants, whose toxicity is mainly attributed to the flavoenzyme electrontransferase-catalyzed redox cycling of their free radicals (oxidative stress) and DT-diaphorase [NAD(P)H:quinone oxidoreductase, NQO1, EC 1.	picric acid	62-82	NAD(P)H dehydrogenase, quinone 1	Mus musculus	319-332
18810995-1	2008	Nitroaromatic explosives like 2,4,6-trinitrotoluene (TNT) and 2,4,6-trinitrophenyl-N-methyl-nitramine (tetryl) comprise an important group of toxic environmental pollutants, whose toxicity is mainly attributed to the flavoenzyme electrontransferase-catalyzed redox cycling of their free radicals (oxidative stress) and DT-diaphorase [NAD(P)H:quinone oxidoreductase, NQO1, EC 1.	picric acid	62-82	crystallin, zeta	Mus musculus	342-364
18810995-1	2008	Nitroaromatic explosives like 2,4,6-trinitrotoluene (TNT) and 2,4,6-trinitrophenyl-N-methyl-nitramine (tetryl) comprise an important group of toxic environmental pollutants, whose toxicity is mainly attributed to the flavoenzyme electrontransferase-catalyzed redox cycling of their free radicals (oxidative stress) and DT-diaphorase [NAD(P)H:quinone oxidoreductase, NQO1, EC 1.	picric acid	62-82	NAD(P)H dehydrogenase, quinone 1	Mus musculus	366-370
17823266-8	2007	In experiment 2 we examined colocalization of kisspeptin and NKB in picric-acid fixed tissue collected from ovary intact ewes (n = 9).	picric acid	68-79	tachykinin precursor 3	Homo sapiens	61-64
17675587-4	2007	Furthermore, ATP-induced vasodilation was inhibited by both suramin and 2",3"-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), consistent with a P2X(1)-, P2X(2)-, or P2X(3)-mediated event and was not potentiated by ivermectin, indicating that these responses were not P2X(4) receptor-mediated.	picric acid	108-111	purinergic receptor P2X, ligand-gated ion channel, 1	Mus musculus	136-139
17675587-4	2007	Furthermore, ATP-induced vasodilation was inhibited by both suramin and 2",3"-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), consistent with a P2X(1)-, P2X(2)-, or P2X(3)-mediated event and was not potentiated by ivermectin, indicating that these responses were not P2X(4) receptor-mediated.	picric acid	108-111	purinergic receptor P2X, ligand-gated ion channel, 2	Mus musculus	145-151
17675587-4	2007	Furthermore, ATP-induced vasodilation was inhibited by both suramin and 2",3"-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), consistent with a P2X(1)-, P2X(2)-, or P2X(3)-mediated event and was not potentiated by ivermectin, indicating that these responses were not P2X(4) receptor-mediated.	picric acid	108-111	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	157-163
17675587-4	2007	Furthermore, ATP-induced vasodilation was inhibited by both suramin and 2",3"-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP), consistent with a P2X(1)-, P2X(2)-, or P2X(3)-mediated event and was not potentiated by ivermectin, indicating that these responses were not P2X(4) receptor-mediated.	picric acid	108-111	purinergic receptor P2X, ligand-gated ion channel 4	Mus musculus	259-265
17218316-0	2007	TRPA1 is differentially modulated by the amphipathic molecules trinitrophenol and chlorpromazine.	picric acid	63-77	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
17218316-6	2007	TRPA1 was robustly activated by the anionic amphipathic molecule trinitrophenol.	picric acid	65-79	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
16199664-5	2005	This novel BFP/TNP-ATP FRET pair demonstrated efficient energy transfer as evidenced by appreciable BFP-donor quenching by bound TNP-ATP.	picric acid	15-18	ring finger protein 112	Homo sapiens	100-103
16199664-7	2005	The estimated distances from the BFP module to the TNP-ATP-occupied active site for the full-length and C-terminally truncated proteins also reveal the possible folding geometry of this domain with respect to the kinase core.	picric acid	51-54	ring finger protein 112	Homo sapiens	33-36
15651782-6	2005	Molecular mechanics calculations indicated that the conformation of the energy-minimized 4a-2Ag+ picrate complex had two crushed pyramidal geometries made up of Ag+ ion and four sulfur atoms, i.e., S1, S2, S4, S5 and S6, S7, S9, S10, respectively.	picric acid	97-104	ribosomal protein S10	Homo sapiens	229-232
12807351-5	2003	We have assessed in the reporter antigen-popliteal lymph node assay whether HCB or TCHQ and TCBQ are able to induce a 2,4,6-trinitrophenyl (TNP) specific IgG1 response to the T cell-independent antigen TNP-Ficoll, which is indicative of neoantigen specific T cell help.	picric acid	118-138	LOC105243590	Mus musculus	154-158
11956191-6	2002	The affinities for TNP-ATP binding to K(ATP) COOH termini of Kir1.1, Kir6.1, and Kir6.2 were similar.	picric acid	19-22	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	61-67
12381730-3	2002	In addition, PIP(2) competed for TNP-ATP binding on the COOH termini of Kir1.1 and Kir6.x channels, providing a mechanism that can account for PIP(2) antagonism of ATP inhibition of these channels.	picric acid	33-36	prolactin induced protein	Homo sapiens	13-16
12381730-3	2002	In addition, PIP(2) competed for TNP-ATP binding on the COOH termini of Kir1.1 and Kir6.x channels, providing a mechanism that can account for PIP(2) antagonism of ATP inhibition of these channels.	picric acid	33-36	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	72-78
12381730-3	2002	In addition, PIP(2) competed for TNP-ATP binding on the COOH termini of Kir1.1 and Kir6.x channels, providing a mechanism that can account for PIP(2) antagonism of ATP inhibition of these channels.	picric acid	33-36	prolactin induced protein	Homo sapiens	143-146
12549939-5	2003	Both resting and transition state P-glycoprotein showed similar affinity for TNP-ATP/TNP-ADP and unlabeled ATP/ADP.	picric acid	77-80	ATP binding cassette subfamily B member 1	Homo sapiens	34-48
11956191-6	2002	The affinities for TNP-ATP binding to K(ATP) COOH termini of Kir1.1, Kir6.1, and Kir6.2 were similar.	picric acid	19-22	potassium inwardly rectifying channel subfamily J member 8	Homo sapiens	69-75
11956191-6	2002	The affinities for TNP-ATP binding to K(ATP) COOH termini of Kir1.1, Kir6.1, and Kir6.2 were similar.	picric acid	19-22	potassium inwardly rectifying channel subfamily J member 11	Homo sapiens	81-87
11956191-9	2002	Competition of TNP-ATP binding to the Kir1.1 COOH terminus by MgATP was complex with both Mg(2+) and MgATP effects.	picric acid	15-18	potassium inwardly rectifying channel subfamily J member 1	Homo sapiens	38-44
9288117-5	1997	On day 0 all mice were immunized with 100 micrograms trinitrobenzene sulfonic acid (TNP) haptenated ovalbumin (TNP-OVA) in complete Freund"s adjuvant.	picric acid	84-87	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	100-109
11777988-2	2002	In initial studies, we showed that the feeding of trinitrophenol-haptenated colonic protein to SJL/J mice induces CD4(+) regulatory T cells that transfer protection from induction of TNBS-colitis, and that such protection correlates with cells producing TGF-beta, not IL-10.	picric acid	50-64	transforming growth factor, beta 1	Mus musculus	254-262
11777988-2	2002	In initial studies, we showed that the feeding of trinitrophenol-haptenated colonic protein to SJL/J mice induces CD4(+) regulatory T cells that transfer protection from induction of TNBS-colitis, and that such protection correlates with cells producing TGF-beta, not IL-10.	picric acid	50-64	interleukin 10	Mus musculus	268-273
11575777-7	2001	Structural analysis (e.g., covalent N-H bond lengthening) indicates that the hydrogen bond between H3A and 08 of imidazole and betaine respectively (HB2) is slightly stronger than the bond between H1A and O1A of imidazole and picric acid (HB1), although HB1 is shorter than HB2: (dN...O(HB1)= 2.614(1) A, dN...O(HB2) = 2.684(1) A, dH...O(HB1) = 1.630(1) A, dH...O(HB2)= 1.635(1) A, dN-H(HB1) = 1.046(1) A, dN-H(HB2) = 1.057(1) A).	picric acid	226-237	keratin 82	Homo sapiens	149-152
10225870-6	1999	Even in the presence of overt infection, TNP-KLH-plus-rmIL-12-immunized mice were still capable of generating KLH-specific gamma interferon (IFN-gamma) as well as corresponding TNP-specific immunoglobulin G2a (IgG2a) titers.	picric acid	41-44	interferon gamma	Mus musculus	110-150
10225870-6	1999	Even in the presence of overt infection, TNP-KLH-plus-rmIL-12-immunized mice were still capable of generating KLH-specific gamma interferon (IFN-gamma) as well as corresponding TNP-specific immunoglobulin G2a (IgG2a) titers.	picric acid	41-44	immunoglobulin heavy variable V1-9	Mus musculus	210-215
10202045-1	1999	We previously demonstrated that 2,4,6-trinitrophenol (TNP)-OVA immunization leads to a transmural colitis in the IL-2-/- mouse that is caused by IL-12-driven CD4+ Th1 T cells and resembles human Crohn"s disease.	picric acid	32-52	interleukin 2	Mus musculus	113-117
10202045-1	1999	We previously demonstrated that 2,4,6-trinitrophenol (TNP)-OVA immunization leads to a transmural colitis in the IL-2-/- mouse that is caused by IL-12-driven CD4+ Th1 T cells and resembles human Crohn"s disease.	picric acid	54-57	interleukin 2	Mus musculus	113-117
9620356-4	1998	When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4.	picric acid	66-86	interleukin 2	Homo sapiens	191-195
9620356-4	1998	When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4.	picric acid	66-86	interferon gamma	Homo sapiens	200-209
9620356-4	1998	When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4.	picric acid	66-86	interleukin 4	Homo sapiens	242-246
9620356-4	1998	When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4.	picric acid	88-91	interleukin 2	Homo sapiens	191-195
9620356-4	1998	When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4.	picric acid	88-91	interferon gamma	Homo sapiens	200-209
9620356-4	1998	When ovalbumin-specific Th cells were cultured in the presence of 2,4,6 trinitrophenol (TNP)-specific B cells, M150 significantly increased the proliferation of Th cells and the secretion of IL-2 and IFN-gamma and decreased the production of IL-4.	picric acid	88-91	interleukin 4	Homo sapiens	242-246
11285118-6	2001	Monoclonal IgE anti-2,4,6-trinitrophenyl (TNP), administered with TNP-coupled SRBC (SRBC-TNP), can induce an efficient suppression in mice lacking FcgammaRI + RIII + FcepsilonRI (owing to the lack of the common gamma chain, FcRgamma), FcgammaRIIB or FcepsilonRII (CD23).	picric acid	20-40	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	166-177
11285118-6	2001	Monoclonal IgE anti-2,4,6-trinitrophenyl (TNP), administered with TNP-coupled SRBC (SRBC-TNP), can induce an efficient suppression in mice lacking FcgammaRI + RIII + FcepsilonRI (owing to the lack of the common gamma chain, FcRgamma), FcgammaRIIB or FcepsilonRII (CD23).	picric acid	20-40	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	224-232
11285118-6	2001	Monoclonal IgE anti-2,4,6-trinitrophenyl (TNP), administered with TNP-coupled SRBC (SRBC-TNP), can induce an efficient suppression in mice lacking FcgammaRI + RIII + FcepsilonRI (owing to the lack of the common gamma chain, FcRgamma), FcgammaRIIB or FcepsilonRII (CD23).	picric acid	20-40	Fc receptor, IgG, low affinity IIb	Mus musculus	235-246
11285118-6	2001	Monoclonal IgE anti-2,4,6-trinitrophenyl (TNP), administered with TNP-coupled SRBC (SRBC-TNP), can induce an efficient suppression in mice lacking FcgammaRI + RIII + FcepsilonRI (owing to the lack of the common gamma chain, FcRgamma), FcgammaRIIB or FcepsilonRII (CD23).	picric acid	20-40	Fc receptor, IgE, low affinity II, alpha polypeptide	Mus musculus	250-262
11285118-6	2001	Monoclonal IgE anti-2,4,6-trinitrophenyl (TNP), administered with TNP-coupled SRBC (SRBC-TNP), can induce an efficient suppression in mice lacking FcgammaRI + RIII + FcepsilonRI (owing to the lack of the common gamma chain, FcRgamma), FcgammaRIIB or FcepsilonRII (CD23).	picric acid	20-40	Fc receptor, IgE, high affinity I, gamma polypeptide	Mus musculus	264-268
10415005-4	1999	In response to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine, CD40Ltg+ mice developed higher titers of high-affinity IgG and IgG1 Ab than wild-type mice.	picric acid	15-29	LOC105243590	Mus musculus	157-161
10415005-4	1999	In response to trinitrophenol (TNP)-keyhole limpet hemocyanin and tetanus/diphtheria vaccine, CD40Ltg+ mice developed higher titers of high-affinity IgG and IgG1 Ab than wild-type mice.	picric acid	31-34	LOC105243590	Mus musculus	157-161
9575290-14	1998	On the basis of sensitivity to TNP-ATP, and other properties, one of these may correspond to the homomeric P2X2 receptor and the other(s) to heteromeric P2X2/3 receptors.	picric acid	31-34	purinergic receptor P2X 2	Rattus norvegicus	107-111
9415031-1	1997	Mice infected with African trypanosomes produce exceptionally large amounts of serum IgM, a major part of which binds to non-trypanosome antigens such as trinitrophenol and single-strand DNA.	picric acid	154-168	IgM	Bos taurus	85-88
9317162-0	1997	TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice.	picric acid	53-73	transforming growth factor, beta 1	Mus musculus	0-8
9317162-0	1997	TGF-beta production regulates the development of the 2,4,6-trinitrophenol-conjugated keyhole limpet hemocyanin-induced colonic inflammation in IL-2-deficient mice.	picric acid	53-73	interleukin 2	Mus musculus	143-147
9317162-1	1997	A severe, Th1-mediated experimental colitis with similarities to inflammatory bowel disease in humans can be induced by a single injection of 2,4,6-trinitrophenol (TNP)-substituted protein plus adjuvant in IL-2-/- mice.	picric acid	142-162	negative elongation factor complex member C/D	Homo sapiens	10-13
9317162-1	1997	A severe, Th1-mediated experimental colitis with similarities to inflammatory bowel disease in humans can be induced by a single injection of 2,4,6-trinitrophenol (TNP)-substituted protein plus adjuvant in IL-2-/- mice.	picric acid	142-162	interleukin 2	Homo sapiens	206-210
9317162-1	1997	A severe, Th1-mediated experimental colitis with similarities to inflammatory bowel disease in humans can be induced by a single injection of 2,4,6-trinitrophenol (TNP)-substituted protein plus adjuvant in IL-2-/- mice.	picric acid	164-167	negative elongation factor complex member C/D	Homo sapiens	10-13
9317162-1	1997	A severe, Th1-mediated experimental colitis with similarities to inflammatory bowel disease in humans can be induced by a single injection of 2,4,6-trinitrophenol (TNP)-substituted protein plus adjuvant in IL-2-/- mice.	picric acid	164-167	interleukin 2	Homo sapiens	206-210
9317162-3	1997	We show that LP T cells in TNP-KLH-immunized IL-2-/- mice fail to produce TGF-beta early (day 2), whereas LP T cells in TNP-KLH-immunized IL-2+/+ mice exhibit an approximately eightfold rise in TGF-beta secretion.	picric acid	27-30	interleukin 2	Mus musculus	45-49
9376129-2	1997	The equilibrium dissociation constants for sFc gamma RII at GK14.1-coated TNP-cap-DPPE/DPPC planar membranes containing 0.5-25 mol% TNP-cap-DPPE were approximately 1 microM.	picric acid	74-77	kallikrein related-peptidase 14	Mus musculus	60-64
8766555-7	1996	The mercury-induced IgG1 response in (NZB x NZW)F1 and SJL mice was found to be polyclonal and autoantibodies against double-stranded (ds)DNA, IgG, collagen, cardiolipin, phosphatidylethanolamine as well as antibodies against the hapten trinitrophenol were produced.	picric acid	237-251	LOC105243590	Mus musculus	20-24
8946960-1	1996	Association reactions of a recombinant CFTR-NBF-2 polypeptide fused to glutathione S-transferase with guanine nucleotides were monitored quantitatively by recording the fluorescence enhancement of excited trinitrophenol (TNP)-labelled GTP after binding to NBF-2.	picric acid	205-219	CF transmembrane conductance regulator	Homo sapiens	39-43
8946960-1	1996	Association reactions of a recombinant CFTR-NBF-2 polypeptide fused to glutathione S-transferase with guanine nucleotides were monitored quantitatively by recording the fluorescence enhancement of excited trinitrophenol (TNP)-labelled GTP after binding to NBF-2.	picric acid	221-224	CF transmembrane conductance regulator	Homo sapiens	39-43
8902280-6	1996	Avoidance of bitter picric acid was influenced by the Soa locus, but avoidance of acetic acid was not.	picric acid	20-31	sucrose octaacetate aversion	Mus musculus	54-57
8027580-4	1994	The ability of trinitrophenol modified A20 cells to stimulate the hybridomas was completely inhibited by monoclonal, anti-trinitrophenol, or anti-Ia antibodies and was significantly reduced by paraformaldehyde fixation immediately after trinitrophenol modification.	picric acid	15-29	tumor necrosis factor, alpha-induced protein 3	Mus musculus	39-42
8550578-8	1996	A truncated form of the EGF receptor TKD lacking the C-terminal autophosphorylation domain exhibited an enhanced affinity for TNP-ATP, which indicated that the autophosphorylation domain occupied the peptide substrate binding site of the TKD and modulated the binding of the nucleotide substrates.	picric acid	126-129	epidermal growth factor receptor	Homo sapiens	24-36
7705400-6	1995	We have shown that in the presence of a Th2 clone, higher immunization doses (above 100 micrograms trinitrophenol (TNP)-KLH/mouse) result in increased production of IgE and IgG1.	picric acid	99-113	heart and neural crest derivatives expressed 2	Mus musculus	40-43
7705400-6	1995	We have shown that in the presence of a Th2 clone, higher immunization doses (above 100 micrograms trinitrophenol (TNP)-KLH/mouse) result in increased production of IgE and IgG1.	picric acid	99-113	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	173-177
8206428-3	1994	There was a concurrent significant increase in serum IgA specific for trinitrophenol (TNP), phosphorylcholine, cardiolipin and sphingomyelin compared with controls, suggesting an elevation of autoreactive IgA.	picric acid	70-84	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	53-56
8206428-3	1994	There was a concurrent significant increase in serum IgA specific for trinitrophenol (TNP), phosphorylcholine, cardiolipin and sphingomyelin compared with controls, suggesting an elevation of autoreactive IgA.	picric acid	86-89	CD79A antigen (immunoglobulin-associated alpha)	Mus musculus	53-56
8558014-2	1996	We have previously shown that IL-12 promotes a primary Th1 response and suppresses a primary Th2 response in lymph nodes of mice primed with a model hapten-protein conjugate, 2,4,6-trinitrophenyl (TNP)-keyhole limpet hemocyanin (KLH).	picric acid	175-195	heart and neural crest derivatives expressed 2	Mus musculus	93-96
8027580-8	1994	Paraformaldehyde fixation and chloroquine treatment had similar effects on the ability of A20 cells to present ovalbumin to ovalbumin-specific hybridomas as they had on the ability of trinitrophenol modified A20 cells to present trinitrophenol to the trinitrophenol specific hybridomas.	picric acid	184-198	tumor necrosis factor, alpha-induced protein 3	Mus musculus	208-211
8027580-9	1994	One of seven T-cell hybridomas responded to trinitrophenol modified ovalbumin but not other trinitrophenol modified proteins.	picric acid	44-58	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	68-77
7521667-2	1994	Anti-CD48 mAb diminished the contact sensitivity response to the hapten trinitrophenol (TNP).	picric acid	72-86	CD48 antigen	Mus musculus	5-9
7521667-2	1994	Anti-CD48 mAb diminished the contact sensitivity response to the hapten trinitrophenol (TNP).	picric acid	88-91	CD48 antigen	Mus musculus	5-9
8027580-4	1994	The ability of trinitrophenol modified A20 cells to stimulate the hybridomas was completely inhibited by monoclonal, anti-trinitrophenol, or anti-Ia antibodies and was significantly reduced by paraformaldehyde fixation immediately after trinitrophenol modification.	picric acid	122-136	tumor necrosis factor, alpha-induced protein 3	Mus musculus	39-42
8027580-4	1994	The ability of trinitrophenol modified A20 cells to stimulate the hybridomas was completely inhibited by monoclonal, anti-trinitrophenol, or anti-Ia antibodies and was significantly reduced by paraformaldehyde fixation immediately after trinitrophenol modification.	picric acid	122-136	tumor necrosis factor, alpha-induced protein 3	Mus musculus	39-42
8027580-5	1994	Trinitrophenol-modified A20 cultured at 37 degrees C for 2 h prior to fixation was significantly more effective at stimulating the hybridomas than trinitrophenol-modified A20 fixed immediately.	picric acid	0-14	tumor necrosis factor, alpha-induced protein 3	Mus musculus	24-27
8027580-5	1994	Trinitrophenol-modified A20 cultured at 37 degrees C for 2 h prior to fixation was significantly more effective at stimulating the hybridomas than trinitrophenol-modified A20 fixed immediately.	picric acid	147-161	tumor necrosis factor, alpha-induced protein 3	Mus musculus	24-27
8027580-5	1994	Trinitrophenol-modified A20 cultured at 37 degrees C for 2 h prior to fixation was significantly more effective at stimulating the hybridomas than trinitrophenol-modified A20 fixed immediately.	picric acid	147-161	tumor necrosis factor, alpha-induced protein 3	Mus musculus	171-174
8027580-6	1994	The ability of A20 to present trinitrophenol was inhibited by chloroquine.	picric acid	30-44	tumor necrosis factor, alpha-induced protein 3	Mus musculus	15-18
8408044-6	1993	ATP competitively displaced the TNP-ATP binding.	picric acid	32-35	ATPase	Escherichia coli	0-3
8408044-6	1993	ATP competitively displaced the TNP-ATP binding.	picric acid	32-35	ATPase	Escherichia coli	36-39
2060575-0	1991	2,4,6-trinitrophenyl (TNP) responsiveness of anti-TNP (Sp6) transgenic mice.	picric acid	0-20	trans-acting transcription factor 6	Mus musculus	55-58
2060575-4	1991	Sp6, a monoclonal anti-2,4,6-trinitrophenyl (TNP) IgM has been shown to react with a variety of self antigens.	picric acid	23-43	trans-acting transcription factor 6	Mus musculus	0-3
2318895-8	1990	Also, similar to native yeast hexokinase, the fluorescent enhancement observed upon TNP-ATP binding to the synthetic peptide is greater than that observed upon TNP-ADP binding.	picric acid	84-87	hexokinase	Saccharomyces cerevisiae S288C	30-40
1700016-2	1990	Enriched suspensions of basophils were sensitized with IgE anti-trinitrophenol (TNP) hapten which was prepared from hybridoma culture supernatants.	picric acid	64-78	immunoglobulin heavy constant epsilon	Homo sapiens	55-58
1690511-2	1990	Three weeks after immunization with trinitrophenol conjugated bovine serum albumin (TNP17.3-BSA), the left kidneys of rats were perfused with 500 micrograms of TNP6.2-cationized human immunoglobulin G (C-HIgG) or TNP31.3-C-HIgG.	picric acid	36-50	albumin	Rattus norvegicus	69-82
2310016-4	1990	A picrate ion selective electrode is used to monitor the free picrate concentration directly in the presence of albumin and bound ligand.	picric acid	2-9	albumin	Bos taurus	112-119
1691711-2	1990	At this concentration, trinitrophenol-ovalbumin increased histamine release from a basal rate of 4.8 +/- 0.5 to 28.5 +/- 4.6% and peptidoleukotrienes from less than 0.1 to 4.2 +/- 1.3 ng/10(6) cells in the activated cells.	picric acid	23-37	serine (or cysteine) peptidase inhibitor, clade B, member 1, pseudogene	Mus musculus	38-47
2551380-1	1989	ATP and the fluorescent substrate analogue TNP-ATP bind competitively to the gastric H,-K-ATPase.	picric acid	43-46	dynein axonemal heavy chain 8	Homo sapiens	90-96
35611945-4	2022	The pGr-MoS2/GCE exhibited selectivity towards DHBI, in the presence of other toxic contaminants and metal ions such as phenol, dinitrophenol, trinitrophenol, urea and glucose, Hg(II), Ca(II), Ni(II), Zn(II), Cu(II), Na(I) and K(I).	picric acid	143-157	progesterone receptor	Homo sapiens	4-7
2572669-2	1989	Purified CD4+ BALB/c spleen T cells obtained 4-6 wk after total lymphoid irradiation (TLI) helped normal syngeneic B cells to produce a vigorous antibody response to TNP keyhole limpet hemocyanin in adoptive cell transfer experiments.	picric acid	166-169	CD4 antigen	Mus musculus	9-12
2972579-2	1988	We have previously shown that down-regulation by Ts cells after AC injection with 2,4,6-trinitrophenol (TNP)-coupled spleen cells (TNP-Spl) is initiated by the intraocular activation of Ts inducer cells.	picric acid	82-102	plasma serotonin level	Mus musculus	135-138
2972579-2	1988	We have previously shown that down-regulation by Ts cells after AC injection with 2,4,6-trinitrophenol (TNP)-coupled spleen cells (TNP-Spl) is initiated by the intraocular activation of Ts inducer cells.	picric acid	104-107	plasma serotonin level	Mus musculus	135-138
3493439-3	1987	We analysed the diversity of TCRs in a collection of H-2Kb-restricted, 2,4,6-trinitrophenyl (TNP)-specific (H-2Kb/TNP) cytotoxic T-cell (Tc) clones from C57BL/6 mice.	picric acid	71-91	histocompatibility 2, K1, K region	Mus musculus	108-117
2965649-3	1988	Here we demonstrate that pronounced variations in the stringency of MHC restriction, previously reported to occur during long-term culture of 2,4,6-trinitrophenyl (TNP)-specific CTL clones, may occur rapidly in a growth-dependent, reversible manner, i.e. without structural TcR variation.	picric acid	142-162	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	274-277
3121376-1	1987	Using a paraformaldehyde-picric acid-glutaraldehyde-containing fixative and treatment of the tissue with sodium borohydride, numerous and widespread TRH-immunoreactive cell bodies were observed in the central nervous system of colchicine-treated rats, including the olfactory bulb, cortical and hippocampal areas, the caudate nucleus and other subcortical areas, many hypothalamic nuclei, the periaqueductal central gray, pontine nuclei, medulla oblongata and the dorsal horn of the spinal cord.	picric acid	25-36	thyrotropin releasing hormone	Rattus norvegicus	149-152
3539259-2	1986	We found that the picric acid paraformaldehyde perfusion provided satisfactory conditions of fixation for visualizing the progesterone receptor in sections of frozen tissue.	picric acid	18-29	LOW QUALITY PROTEIN: progesterone receptor	Cavia porcellus	122-143
3262520-1	1988	We tested the effect of interferon (IFN)-alpha on the specific anti-2,4,6-trinitrophenyl (TNP) response induced by TNP-conjugated polyacrylamide beads in cultures of purified human B cells.	picric acid	68-88	interferon alpha 1	Homo sapiens	24-46
3770803-2	1986	Eight monoclonal anti-TNP IgG1s, which had similar affinities to the TNP residues in solution and in the membranes, were used in the experiment.	picric acid	22-25	immunoglobulin heavy constant gamma 1 (G1m marker)	Mus musculus	26-30
2875422-1	1986	Picric acid stimulated, in a dose-dependent manner, the release of [14C]acetylcholine (ACh) from isolated synaptosomes of rat cerebral cortex pre-loaded with labelled choline.	picric acid	0-11	acyl-CoA thioesterase 12	Rattus norvegicus	67-91
14878872-2	1951	Effect of 2-4-5 trinitrophenol and of 2-4-6 trinitrophenol on blood catalase].	picric acid	38-58	catalase	Homo sapiens	68-77
2421602-3	1986	The picrate-Coomassie blue method fixed and stained a small peptide (bradykinin, nine amino acids) that was not observed in gels stained with fast green, silver, or Coomassie blue following fixation in 50% trichloroacetic acid.	picric acid	4-11	kininogen 1	Homo sapiens	69-79
6142049-6	1984	Comparison of the TNP-nucleotide fluorescence features in different solvents with that of the TNP-nucleotide bound to sarcoplasmic reticulum ATPase indicates that, following phosphorylation, the binding domain excludes solvent molecules and confers restricted mobility to the TNP-nucleotide.	picric acid	18-21	dynein axonemal heavy chain 8	Homo sapiens	141-147
6182184-2	1982	Under light microscopy, the AFP-containing hepatocytes were successfully demonstrated in paraffin-embedded liver tissues fixed with 4% paraformaldehyde(PFA)-picric acid solution containing 0.5% glutaraldehyde (GA).	picric acid	157-168	alpha fetoprotein	Homo sapiens	28-31
6182184-7	1982	Furthermore, we describe the extreme usefulness of the block-staining method for demonstrating the subcellular localization of AFP using HRP-labeled reduced anti-AFP antisera on liver tissues fixed with 4% PFA-picric acid solution containing 0.5% GA.	picric acid	210-221	alpha fetoprotein	Homo sapiens	127-130
6260144-5	1981	In understanding the somewhat faster rates of the TNP-cytochrome c over native cytochrome c it is possible that (1) TNP-cytochrome c reacts more quickly since modification of the lysine-13 residue destabilizes somewhat the heme crevice or (2) in light of the hydrophobic nature of the trinitrophenyl group and the X-ray crystallographic structure of HiPIP, the TNP group facilitates electron transfer by interacting with a hydrophobic region on the HiPIP molecular surface.	picric acid	50-53	cytochrome c, somatic	Equus caballus	54-66
109569-3	1979	B10 spleen cells did not respond to syngeneic stimulating cells modified at 0.1 mM or lower, whereas B10.BR cells generated effector activity even when stimulated by TNP-self modified with as low as 0.031 mM TNBS.	picric acid	166-169	granzyme C	Mus musculus	101-104
109569-6	1979	These response patterns were verified by stimulating cultures of B10.BR and B10 spleen cells either with TNP conjugated to bovine serum albumin or bovine gamma globulin (B10.BR but not B10 cells responded to TNP-conjugated proteins) or with TNBS-modified glass-adherent spleen cells.	picric acid	105-108	granzyme C	Mus musculus	76-79
109569-6	1979	These response patterns were verified by stimulating cultures of B10.BR and B10 spleen cells either with TNP conjugated to bovine serum albumin or bovine gamma globulin (B10.BR but not B10 cells responded to TNP-conjugated proteins) or with TNBS-modified glass-adherent spleen cells.	picric acid	105-108	granzyme C	Mus musculus	76-79
109569-6	1979	These response patterns were verified by stimulating cultures of B10.BR and B10 spleen cells either with TNP conjugated to bovine serum albumin or bovine gamma globulin (B10.BR but not B10 cells responded to TNP-conjugated proteins) or with TNBS-modified glass-adherent spleen cells.	picric acid	105-108	granzyme C	Mus musculus	76-79
80421-0	1978	Relationship between trinitrophenol and H-2 antigens on trinitrophenyl-modified spleen cells.	picric acid	21-35	relaxin 2	Homo sapiens	40-43
6184323-7	1983	When leukocytes were incubated with TNP-labeled myeloma IgE and subsequently with fluorescein-labeled anti-TNP antibodies, no fluorescence was observed on basophil leukocytes, although binding of TNP-labeled IgE was demonstrated by anti-TNP antiserum-induced histamine release.	picric acid	36-39	immunoglobulin heavy constant epsilon	Homo sapiens	56-59
6970766-2	1981	We found that stimulation of nude mouse splenocytes with trinitrophenol (TNP)-derivatized autologous or allogeneic spleen cells in the presence of IL-2 generated hapten-specific CTL.	picric acid	57-71	interleukin 2	Mus musculus	147-151
6970766-2	1981	We found that stimulation of nude mouse splenocytes with trinitrophenol (TNP)-derivatized autologous or allogeneic spleen cells in the presence of IL-2 generated hapten-specific CTL.	picric acid	73-76	interleukin 2	Mus musculus	147-151
508733-4	1979	Picric acid, antimycin A and tetraphenylboron were also able to induce cytochrome b-559 photooxidation in chloroplast fragments, but not in whole cells.	picric acid	0-11	cytochrome b	Chlamydomonas reinhardtii	71-83
311343-2	1979	The LPS was extracted from a rough strain of bacteria (Salmonella minnesota R595) and chemically haptenated with either trinitrophenol or fluorescein isothiocyanate.	picric acid	120-134	toll-like receptor 4	Mus musculus	4-7
690447-0	1978	Relationship between trinitrophenol and H-2 antigens on trinitrophenyl-modified spleen cells.	picric acid	21-35	relaxin 2	Homo sapiens	40-43
303685-4	1977	We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS-responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added.	picric acid	60-63	toll-like receptor 4	Mus musculus	73-76
303685-4	1977	We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS-responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added.	picric acid	60-63	toll-like receptor 4	Mus musculus	98-101
303685-4	1977	We found that C3H/HeJ spleen cells produce antibody to MRBC-TNP when (a) LPS and macrophages from LPS-responsive C3HeB/FeJ mice or (b) tumor necrosis serum ([TNS] induced by LPS in responsive mice) are added.	picric acid	60-63	toll-like receptor 4	Mus musculus	98-101
1082923-0	1976	Virus and trinitrophenol hapten-specific T-cell-mediated cytotoxicity against H-2 incompatible target cells.	picric acid	10-24	histocompatibility-2, MHC	Mus musculus	78-81
33137228-2	2020	To address this issue, herein, we report a Perylenediimide-Peptide conjugate, PDI-1 , for detection of PA in methanol.	picric acid	103-105	peptidyl arginine deiminase 1	Homo sapiens	78-83
33336580-0	2022	3.5-scFv-beta-lactamase, a new protein detector of picric acid, the highly nitrated organic explosive.	picric acid	51-62	beta-lactamase	Escherichia coli	9-23
33930851-5	2021	On the one hand, due to their excellent conjugated properties and nitrogen-enriched structures, HBP and TBP exhibited incredibly high sensitivity to m-dinitrobenzene (m-DNB) and picric acid (PA) with KSV values of 2.57 x 105 and 4.93 x 104 L mol-1 and limits of detection of 1.17 x 10-11 and 6.08 x 10-11 mol L-1, respectively.	picric acid	178-189	heme binding protein 1	Homo sapiens	96-99
33930851-5	2021	On the one hand, due to their excellent conjugated properties and nitrogen-enriched structures, HBP and TBP exhibited incredibly high sensitivity to m-dinitrobenzene (m-DNB) and picric acid (PA) with KSV values of 2.57 x 105 and 4.93 x 104 L mol-1 and limits of detection of 1.17 x 10-11 and 6.08 x 10-11 mol L-1, respectively.	picric acid	191-193	heme binding protein 1	Homo sapiens	96-99