PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2583860-6	1989	Immunohistochemical analysis of formalin-fixed paraffin sections, using a polyclonal antibody against pS2 protein, showed specific staining of both cytoplasm and membrane of epithelial cells in the neck region of antral and body glands as well as in luminal secretions.	Paraffin	47-55	taste 2 receptor member 64 pseudogene	Homo sapiens	102-105
2575741-4	1989	In these specimens, fixed in Bouin"s solution and embedded in paraffin, CD 15 antigen was detected in the Reed-Sternberg cells and the mononuclear variety of Hodgkin cells in 64 patients (59%).	Paraffin	62-70	fucosyltransferase 4	Homo sapiens	72-77
2478107-3	1989	We used the avidin-biotin-peroxidase method to identify this material using antibodies to the serum glycoproteins carcinoembryonic antigen, alpha 1-antitrypsin, and alpha-fetoprotein on paraffin sections of pancreas obtained from a total of 21 patients: 9 with cystic fibrosis, 5 with chronic pancreatitis, and 7 controls.	Paraffin	186-194	alpha fetoprotein	Homo sapiens	165-182
2790701-0	1989	Immunohistochemical estrogen receptor determination in paraffin-embedded tissue.	Paraffin	55-63	estrogen receptor 1	Homo sapiens	20-37
2790701-2	1989	A new immunohistochemical assay using a monoclonal estrogen receptor (ER) antibody (H222, Abbott Laboratories, North Chicago) for determination of ER in formalin-fixed paraffin-embedded tissue was applied to evaluate its clinical value in a group of 145 previously untreated patients with advanced breast cancer.	Paraffin	168-176	estrogen receptor 1	Homo sapiens	147-149
2790701-7	1989	It is concluded that ER analysis in formalin-fixed paraffin-embedded tissue offers clinically useful information for allocation of patients to endocrine therapy.	Paraffin	51-59	estrogen receptor 1	Homo sapiens	21-23
2816820-4	1989	Immunohistochemical ER was assessed in 68 breast carcinomas, by an automated method using routinely processed formalin-fixed paraffin-embedded tissues, and manually with the use of snap-frozen tissues with a monoclonal anti-ER and peroxidase-antiperoxidase technique.	Paraffin	125-133	estrogen receptor 1	Homo sapiens	20-22
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Paraffin	171-179	interleukin 1 beta	Homo sapiens	122-131
2573621-0	1989	Comparative quality assessment in immunocytochemistry: pilot study of CD15 staining in paraffin wax embedded tissue in Hodgkin"s disease.	Paraffin	87-99	fucosyltransferase 4	Homo sapiens	70-74
2789247-1	1989	We investigated the immunohistochemical localization of osteocalcin in demineralized, paraffin-embedded normal and pathological human bone.	Paraffin	86-94	bone gamma-carboxyglutamate protein	Homo sapiens	56-67
2661407-1	1989	A panel of paraffin effective antibodies recognizing B cells and T cells (LN-2, MB1, L26, MT1, UCHL1, kappa, lambda) was used to characterize the immunophenotypes of 26 sinonasal non-Hodgkin"s lymphomas.	Paraffin	11-19	CD79a molecule	Homo sapiens	80-83
2768839-2	1989	In order to improve the detection of DNA aneuploidy in malignant melanomas, and to minimize diploid non-tumor cells in the sample, we developed a two-color staining strategy for S100 protein and DNA content in paraffin embedded samples.	Paraffin	210-218	S100 calcium binding protein A1	Homo sapiens	178-182
2807979-2	1989	In 5 microns paraffin sections most epithelial cells exhibited a pronounced immunoperoxidase staining for transferrin.	Paraffin	13-21	transferrin	Rattus norvegicus	106-117
2572685-3	1989	Antibodies to the protein product, p185, have been used for immunostaining of paraffin-embedded material, and have demonstrated that high levels of c-erbB-2 protein expression correlate with gene amplification under certain conditions.	Paraffin	78-86	erb-b2 receptor tyrosine kinase 2	Homo sapiens	148-156
2570047-4	1989	This study shows that overexpression of the c-erb B-2 oncoprotein is easily identifiable and can be detected on paraffin embedded sections using an immunohistochemical technique.	Paraffin	112-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	44-53
2551430-2	1989	A monoclonal antibody prepared from chicken type II collagen was used with paraffin sections, employing the ABC (avidin biotinylated horseradish peroxidase complex) peroxidase technique.	Paraffin	75-83	collagen type II alpha 1 chain	Gallus gallus	44-60
2470247-5	1989	In this study, paraffin-embedded tissue (PET) fixed in 10% (v/v) neutral buffered formalin (NBF) produced the best results, with a %CV below 4.7, whereas fixatives such as Zenker"s and B-5 produced poor %CVs (above 6.0) or uninterpretable TNP and light scatter data.	Paraffin	15-23	glycoprotein hormone subunit beta 5	Homo sapiens	185-188
2544220-3	1989	EGF-R status was assessed on routinely embedded paraffin sections with an antibody to the cytoplasmic domain of the tumour (F4 antibody).	Paraffin	48-56	epidermal growth factor receptor	Homo sapiens	0-5
2750677-9	1989	In paraffin sections of melanoma colonies, FN was observed associated with both the cell surface and the ECM.	Paraffin	3-11	fibronectin 1	Homo sapiens	43-45
2714341-1	1989	Monoclonal antibodies against an estrogen-regulated Mr 24,000 cytosol protein (p24) were used for immunocytochemical localization of p24 in formalin-fixed paraffin-embedded specimens from the primary tumor in 103 patients who received endocrine therapy for advanced breast cancer.	Paraffin	155-163	transmembrane p24 trafficking protein 2	Homo sapiens	79-82
2709813-1	1989	The distribution of the messenger ribonucleic acids (mRNAs) for chromogranin A and B was analyzed by in situ hybridization in normal and neoplastic endocrine tissues using frozen and paraffin tissue sections.	Paraffin	183-191	chromogranin A	Homo sapiens	64-84
2542151-3	1989	A monoclonal antibody directed at a 15-kilodalton (kd) gross cystic disease fluid protein (GCDFP-15) was applied immunohistochemically to paraffin sections of 105 breast cancers and 585 nonmammary malignancies in order to assess its value in this context.	Paraffin	138-146	prolactin induced protein	Homo sapiens	91-99
2654041-1	1989	Standard immunoperoxidase techniques were used to investigate the distribution of the intracellular proteinase cathepsin D, two serine proteinase inhibitors--alpha 1-antitrypsin (alpha 1-AT) and alpha 1-antichymotrypsin (alpha 1-AChy)--and plasma fibrin stabilizing factor XIII (FXIII) in paraffin-embedded tissues from early and late intrauterine pregnancy and ectopic pregnancy.	Paraffin	289-297	endogenous retrovirus group K member 25	Homo sapiens	100-110
2480629-4	1989	The NCA epitope recognized by MAb 47D10 is well preserved in formalin-fixed and paraffin-embedded tissues.	Paraffin	80-88	CEA cell adhesion molecule 4	Homo sapiens	4-7
2468075-7	1989	In paraffin sections as well as in frozen sections, ER staining was located at the nuclei of cancer cells.	Paraffin	3-11	estrogen receptor 1	Homo sapiens	52-54
2922380-0	1989	[Immunohistochemical demonstration of HIV-p24 antigen in formalin fixed and paraffin embedded brain and spinal cord tissue].	Paraffin	76-84	transmembrane p24 trafficking protein 2	Homo sapiens	42-45
2468075-0	1989	[Immunocytochemical staining of estrogen receptor in conventional formalin-fixed paraffin sections in human breast cancer].	Paraffin	81-89	estrogen receptor 1	Homo sapiens	32-49
2468075-3	1989	The ER stainability in formalin-fixed paraffin sections was compared with the levels of ER measuring dextran-coated charcoal (DCC) method, and with the stainability of ER in frozen sections.	Paraffin	38-46	estrogen receptor 1	Homo sapiens	4-6
2468075-4	1989	ER positive rates of paraffin sections and frozen sections were 52%, and 65% respectively.	Paraffin	21-29	estrogen receptor 1	Homo sapiens	0-2
2468075-6	1989	Results of ER staining in paraffin sections correlated well to those of DCC method and to those of ER staining in frozen sections.	Paraffin	26-34	estrogen receptor 1	Homo sapiens	11-13
2565624-2	1989	Our results demonstrate that the epitopes unique to proinsulin and insulin can be detected with the respective monoclonal antibodies using the protein A-gold technique after routine formaldehyde fixation and paraffin embedding of the tissues.	Paraffin	208-216	insulin	Homo sapiens	55-62
2565624-2	1989	Our results demonstrate that the epitopes unique to proinsulin and insulin can be detected with the respective monoclonal antibodies using the protein A-gold technique after routine formaldehyde fixation and paraffin embedding of the tissues.	Paraffin	208-216	insulin	Homo sapiens	52-62
2904980-0	1988	Immunohistochemical characterization of osteoclasts and osteoclast-like cells with monoclonal antibody MB1 on paraffin-embedded tissues.	Paraffin	110-118	CD79a molecule	Homo sapiens	103-106
2903446-3	1988	We describe a method for the immunohistochemical detection of overexpression of neu protein on formalin-fixed paraffin-embedded tissue, with the use of two different monoclonal antibodies.	Paraffin	110-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	80-83
2844401-2	1988	A new cell line (SIM-1) was derived from a peripheral neuroectodermal tumor (PNET) and used for the production of a monoclonal antibody (HBA-71), which recognizes a novel cell surface antigen of ES- and PNET-derived cells and paraffin-embedded tumor sections.	Paraffin	226-234	CD99 molecule (Xg blood group)	Homo sapiens	137-143
2458833-2	1988	Polyclonal, monospecific rabbit antibody to human FN was applied on formalin-fixed, paraffin-embedded tissue sections using the peroxidase-antiperoxidase staining technique.	Paraffin	84-92	fibronectin 1	Homo sapiens	50-52
2904980-1	1988	In this study we provide evidence that MB1, a newly developed monoclonal antibody which reacts with B lymphocytes and a proportion of T cells and monocytes, can be successfully used for the direct immunohistochemical identification of osteoclasts on paraffin-embedded surgical specimens.	Paraffin	250-258	CD79a molecule	Homo sapiens	39-42
2904980-3	1988	MB1 is thus proposed as a new immunohistochemical marker for osteoclasts on paraffin-embedded material.	Paraffin	76-84	CD79a molecule	Homo sapiens	0-3
2457423-1	1988	The expression of the alpha-fetoprotein (AFP) gene in hepatocellular carcinoma (HCC) and liver cirrhosis by in situ hybridization analysis of AFP mRNA in cryostat and paraffin-embedded tissue sections was studied.	Paraffin	167-175	alpha fetoprotein	Homo sapiens	22-39
2457423-1	1988	The expression of the alpha-fetoprotein (AFP) gene in hepatocellular carcinoma (HCC) and liver cirrhosis by in situ hybridization analysis of AFP mRNA in cryostat and paraffin-embedded tissue sections was studied.	Paraffin	167-175	alpha fetoprotein	Homo sapiens	41-44
2845551-1	1988	The expression of carcinoembryonic antigen (CEA) and related antigens in 40 formalin-fixed paraffin embedded tissues of 4 histological types of lung carcinomas was examined immunohistochemically using five monoclonal antibodies (MoABs) which distinguished different epitopes on CEA, and the correlation with serum-CEA (s-CEA) level and tissue-CEA (t-CEA) was also investigated.	Paraffin	91-99	CEA cell adhesion molecule 3	Homo sapiens	44-47
3046341-3	1988	We performed a semiquantitative analysis of the immunohistochemical distribution of renin in the kidneys of ten patients with end-stage renal disease and hypertension using a specific antihuman renin antibody and a peroxidase-antiperoxidase technique on paraffin sections of nephrectomy and/or autopsy specimens.	Paraffin	254-262	renin	Homo sapiens	84-89
3237544-2	1988	The use of oligonucleotide probes for hPRL and hGH labeled with 35S allowed detection of a specific messenger RNA in frozen and paraffin sections.	Paraffin	128-136	prolactin	Homo sapiens	38-42
3248478-12	1988	The human HMG1-IgM reacted with gastric cancer cells on paraffin embedded tissue section but did not react with normal gastric mucosa cells.	Paraffin	56-64	high mobility group box 1 pseudogene 5	Homo sapiens	10-14
2456979-1	1988	Immunoreactivity for S-100 protein, typically a marker for malignant melanoma and neural-derived tumors, was observed in neoplastic cells of 57 of 68 cases (84%) of formalin-fixed, paraffin-embedded primary and/or metastatic carcinoma of the breast of various histologic types.	Paraffin	181-189	S100 calcium binding protein A1	Homo sapiens	21-26
2903028-5	1988	By use of the peroxidase-antiperoxidase method of immunoperoxidase staining, antibodies to the PCB-binding protein were found to stain the Clara cells in sections of paraffin-embedded rat lungs.	Paraffin	166-174	secretoglobin family 1A member 1	Rattus norvegicus	95-114
3365669-1	1988	A study of two monoclonal antibodies compared with S-100 protein in paraffin sections.	Paraffin	68-76	S100 calcium binding protein A1	Homo sapiens	51-56
3279749-4	1988	However, negative results for S-100 protein staining were obtained in paraffin splenic sections of HCL cases.	Paraffin	70-78	S100 calcium binding protein A1	Homo sapiens	30-35
3292593-5	1988	Fibronectin was found in gingival crevices and in unstimulated as well as paraffin-stimulated whole saliva in pre- and post-treatment samples.	Paraffin	74-82	fibronectin 1	Homo sapiens	0-11
3360152-2	1988	We briefly review the literature on this subject with emphasis on our own results on immunohistochemical detection of neu overproduction in paraffin embedded tissue sections of human breast carcinomas.	Paraffin	140-148	erb-b2 receptor tyrosine kinase 2	Homo sapiens	118-121
3359893-7	1988	If the methodological variation and the intratumor variation were taken into account, there was a good correlation between DNA indices (r = 0.980) and between SPF values (r = 0.794) obtained from fresh and paraffin-embedded tumors.	Paraffin	206-214	SEC14 like lipid binding 2	Homo sapiens	159-162
2893663-9	1988	This is the first study showing that a determination of the level of c-erbB-2 protein in paraffin-embedded tumor sections may have prognostic value for the course of human breast cancer.	Paraffin	89-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-77
3359893-1	1988	Flow cytometric analysis of DNA ploidy and S-phase fraction (SPF) from paraffin-embedded tumors has become an important diagnostic and prognostic tool in clinical pathology and investigative oncology.	Paraffin	71-79	SEC14 like lipid binding 2	Homo sapiens	61-64
3321071-1	1987	The expression of the pS2 gene, which is induced by estrogen in the breast cancer cell line MCF-7, has been investigated in breast cancers by using pS2 mRNA determination in tumor specimens and immunocytochemistry to identify pS2 protein in paraffin-embedded sections.	Paraffin	241-249	taste 2 receptor member 64 pseudogene	Homo sapiens	22-25
3285295-4	1988	Immunohistochemistry on paraffin-embedded sections of tumors in which the neu gene was amplified showed distinct membrane staining of groups of tumor cells.	Paraffin	24-32	erb-b2 receptor tyrosine kinase 2	Homo sapiens	74-77
3146857-1	1988	The distribution pattern of fibronectin in the human placenta has been studied using the indirect immunoperoxidase (PAP) technique on formalin fixed paraffin embedded tissue samples.	Paraffin	149-157	fibronectin 1	Homo sapiens	28-39
3179032-6	1988	By paired staining for L1 and S-100 protein, macrophages and DC of the interdigitating or Langerhans type can be visualized simultaneously in routine formalin-fixed paraffin sections.	Paraffin	165-173	immunoglobulin kappa variable 1-16	Homo sapiens	23-35
2468461-4	1988	A positive reaction to AFP was demonstrated in the tumor cells in the ascitic fluid cellular samples as well as in the paraffin-embedded tissue section of the primary gastric carcinoma.	Paraffin	119-127	alpha fetoprotein	Homo sapiens	23-26
2825550-0	1987	Immunostaining of estrogen receptor in paraffin sections of breast carcinomas using monoclonal antibody D75P3 gamma: effects of fixation.	Paraffin	39-47	estrogen receptor 1	Homo sapiens	18-35
2825550-1	1987	Immunostaining of estrogen receptor was carried out on paraffin sections of breast carcinomas using an anti-estrophilin monoclonal antibody (D75P3 gamma) and the avidin-biotin technique.	Paraffin	55-63	estrogen receptor 1	Homo sapiens	18-35
2825550-4	1987	The estrogen receptor immunostaining on paraffin sections was found to be in concordance with that on frozen sections (Abbott ER-ICA) and with the steroid-binding assay (dextran-coated charcoal) in over 90% of the cases.	Paraffin	40-48	estrogen receptor 1	Homo sapiens	4-21
3440754-1	1987	Immunocytochemical studies with a monoclonal antibody (MAb-HL3), which recognises a major isozyme of human hepatic cytochrome P-450, have demonstrated this cytochrome in both cryostat and formalin-fixed paraffin-embedded sections of normal human adult liver.	Paraffin	203-211	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	115-131
3323430-10	1987	While the monoclonal antibodies MB1 and MT1 are of use in classifying lymphomas in paraffin section, they are not entirely lineage-specific, and the uncritical use of these two reagents alone may give rise to misdiagnosis; the use of a panel of monoclonal antibodies may yield more accurate results.	Paraffin	83-91	CD79a molecule	Homo sapiens	32-35
3668732-4	1987	Mab F4 is the first antibody to the EGF receptor to show reactivity in paraffin sections.	Paraffin	71-79	epidermal growth factor receptor	Homo sapiens	36-48
3032126-1	1987	The possible production of the opioid polypeptide beta-endorphin (beta-EP) was investigated in paraffin-embedded tissue from 17 ovarian tumors with the use of a specific anti-beta-EP antibody and the avidin-biotin-peroxidase staining technique.	Paraffin	95-103	proopiomelanocortin	Homo sapiens	50-64
3032126-1	1987	The possible production of the opioid polypeptide beta-endorphin (beta-EP) was investigated in paraffin-embedded tissue from 17 ovarian tumors with the use of a specific anti-beta-EP antibody and the avidin-biotin-peroxidase staining technique.	Paraffin	95-103	proopiomelanocortin	Homo sapiens	66-73
3026257-6	1987	Identification of NSE as assessed by immunohistochemical procedure employing the ABC method on formalin-fixed paraffin-embedded tissue sections in lung cancer cases of each histological type, showed that some materials from non-SCLC cases were positively stained despite the presence of normal serum NSE levels, and did not always parallel the serum levels.	Paraffin	110-118	enolase 2	Homo sapiens	18-21
2433953-2	1987	The expression of carcinoembryonic antigen (CEA) and related antigens in formalin-fixed paraffin-embedded tissues of 200 primary thyroid carcinomas and 22 nonmalignant thyroid lesions was studied immunocytochemically by using three monoclonal antibodies recognizing different epitopes on CEA and related antigens.	Paraffin	88-96	CEA cell adhesion molecule 3	Homo sapiens	18-42
2433953-2	1987	The expression of carcinoembryonic antigen (CEA) and related antigens in formalin-fixed paraffin-embedded tissues of 200 primary thyroid carcinomas and 22 nonmalignant thyroid lesions was studied immunocytochemically by using three monoclonal antibodies recognizing different epitopes on CEA and related antigens.	Paraffin	88-96	CEA cell adhesion molecule 3	Homo sapiens	44-47
2880658-1	1987	Stage-specific embryonic antigen-1 (SSEA-1) was localized on paraffin embedded, formalin fixed specimens of human renal tumors by immunoperoxidase staining using a monoclonal antibody.	Paraffin	61-69	fucosyltransferase 4	Homo sapiens	0-42
3545275-5	1987	Twenty-nine paraffin-embedded sections from other NPC patients stained with HNK-1 antibody showed a variable percentage of positive cells reaching 6 to 15% in nine patients.	Paraffin	12-20	beta-1,3-glucuronyltransferase 1	Homo sapiens	76-81
3540244-7	1986	The results show that MB1 and MT1 are useful markers for B and T cells in routinely fixed paraffin embedded tissue.	Paraffin	90-98	CD79a molecule	Homo sapiens	22-25
3319920-0	1987	Estrogen receptor localization in formalin-fixed, paraffin-embedded endometrium and endometriotic tissues.	Paraffin	50-58	estrogen receptor 1	Homo sapiens	0-17
3319920-1	1987	Monoclonal estrogen receptor (ER) antibody and indirect immunoperoxidase techniques were used to study the immunohistochemical localization of ER in paraffin sections of 20 surgical specimens containing foci of endometriosis.	Paraffin	149-157	estrogen receptor 1	Homo sapiens	143-145
3746349-1	1986	Copper-zinc superoxide dismutase (CuZn-SOD) has been localized in formalin-fixed, paraffin-embedded sections of both canine and rat brains.	Paraffin	82-90	superoxide dismutase 1	Rattus norvegicus	34-42
3531699-3	1986	This study uses an immunoperoxidase technique for localization of involucrin in paraffin sections of normal conjunctiva, conjunctival dysplasia, carcinoma in situ, and invasive carcinoma.	Paraffin	80-88	involucrin	Homo sapiens	66-76
3083888-5	1986	Antibodies of all seven clones can be used for immunomorphological identification of cytochrome P-450 on rat liver paraffin sections.	Paraffin	115-123	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	85-101
3706782-5	1986	By light microscope examination of seminal vesicle tissue in paraffin section, the MHS-5 antigen was localized in principal cells of the seminal vesicle epithelium.	Paraffin	61-69	calcium voltage-gated channel subunit alpha1 S	Homo sapiens	83-88
3463926-6	1986	Generally, the most practical way to confirm the diagnosis, in everyday practice, on fixed paraffin-embedded tissues is the demonstration of alpha-1-antitrypsin (A1AT) and/or lysozyme by the immunoperoxidase technique.	Paraffin	91-99	serpin family A member 1	Homo sapiens	141-160
2422595-1	1986	The distribution of substance P immunoreactive sites was investigated by immunoenzymatic methods in a large series of paraffin embedded human brain sections from the collection assembled by Oscar and Cecile Vogt several decades ago, as well as from more recent post-mortem material.	Paraffin	118-126	tachykinin precursor 1	Homo sapiens	20-31
2419044-1	1986	In this investigation, the presence of calcitonin and calmodulin has been demonstrated in immunoperoxidase formalin-fixed, paraffin-embedded sections of lung from autopsy tissues of four patients who died as a result of complications resulting from their cystic fibrosis disease.	Paraffin	123-131	calmodulin 1	Homo sapiens	54-64
3511322-0	1986	Monoclonal and polyclonal antibodies for the immunohistochemical detection of S-100 protein in paraffin embedded human tissues.	Paraffin	95-103	S100 calcium binding protein A1	Homo sapiens	78-83
3515832-1	1986	The immunoreactivity of the anti-Leu 7 (HNK-1) monoclonal antibody, a marker for natural killer cells, was evaluated with the peroxidase-anti-peroxidase (PAP) method on sections of human paraffin-embedded tissues from 135 tumors of the central nervous system and five esthesioneuroblastomas.	Paraffin	187-195	beta-1,3-glucuronyltransferase 1	Homo sapiens	33-38
3515832-1	1986	The immunoreactivity of the anti-Leu 7 (HNK-1) monoclonal antibody, a marker for natural killer cells, was evaluated with the peroxidase-anti-peroxidase (PAP) method on sections of human paraffin-embedded tissues from 135 tumors of the central nervous system and five esthesioneuroblastomas.	Paraffin	187-195	beta-1,3-glucuronyltransferase 1	Homo sapiens	40-45
2863627-0	1985	Practical importance of immunostaining paraffin-embedded biopsy samples of small lymphocytic and follicle centre cell lymphomas for S100 protein.	Paraffin	39-47	S100 calcium binding protein A1	Homo sapiens	132-136
3942531-2	1986	Rhodopsin was identified in formaldehyde-fixed, paraffin-embedded human fetal retina, and in five retinoblastomas using monoclonal antibody (MAb) MAb-E.	Paraffin	48-56	rhodopsin	Homo sapiens	0-9
3004013-1	1986	The expression of CEA and related antigens in formalin-fixed paraffin-embedded tissues of normal pancreas and different pancreatic neoplasms was studied immunocytochemically using three monoclonal antibodies (MAbs) recognizing different epitopes on CEA and related antigens.	Paraffin	61-69	CEA cell adhesion molecule 3	Homo sapiens	18-21
3004013-11	1986	The findings suggest that paraffin-embedded tissues of pancreatic duct type carcinomas, in contrast to nonduct type tumours and normal ducts, are distinguished by the presence of a CEA and NCA 95 related epitope.	Paraffin	26-34	CEA cell adhesion molecule 3	Homo sapiens	181-184
3004013-11	1986	The findings suggest that paraffin-embedded tissues of pancreatic duct type carcinomas, in contrast to nonduct type tumours and normal ducts, are distinguished by the presence of a CEA and NCA 95 related epitope.	Paraffin	26-34	CEA cell adhesion molecule 8	Homo sapiens	189-195
2411380-1	1985	Fibronectin, a high molecular weight glycoprotein component of the extracellular matrix, was localized extracellularly and intracellularly in the nuclei and the cytoplasm of hepatocellular carcinomas (HCC) by the use of the biotin-avidin method on paraffin-embedded, pepsin-treated tissue.	Paraffin	248-256	fibronectin 1	Homo sapiens	0-11
2417446-5	1985	Linear and nodular deposition of IgG, IgA, IgM, alpha 1-AT, Hpt, and beta-Lp were observed in the glomerular capillary walls of the renal specimens embedded in paraffin matrix.	Paraffin	160-168	serpin family A member 1	Homo sapiens	48-58
3513457-1	1986	Carcinoembryonic antigen (CEA) and S 100 protein (S 100) have been demonstrated in formalin-fixed paraffin sections of eccrine and apocrine sweat glands, and tumors of the sweat glands, as well as, for comparison, in a variety of tumors deriving from epidermal and follicular structures using the peroxidase-antiperoxidase technique.	Paraffin	98-106	S100 calcium binding protein A1	Homo sapiens	0-56
3911731-7	1985	These results show that immunohistochemical demonstration of S-100 protein and lysozyme can be successfully applied to formalin-fixed, paraffin embedded tissue after storage at room temperature for as long as 15 years.	Paraffin	135-143	S100 calcium binding protein A1	Homo sapiens	61-66
3911732-1	1985	The presence and distribution of S-100 protein antigen and lysozyme were investigated by the immunoperoxidase method in paraffin sections of 13 cases of chronic cutaneous leishmaniasis from Saudi Arabia.	Paraffin	120-128	S100 calcium binding protein A1	Homo sapiens	33-38
2414205-1	1985	Immunoreactivity for S-100 protein was investigated immunohistochemically in a series of 49 fixed and paraffin-embedded normal, reactive, and neoplastic human lymphoid tissue specimens.	Paraffin	102-110	S100 calcium binding protein A1	Homo sapiens	21-26
2415956-8	1985	In conventionally fixed and paraffin embedded specimens of the same tumors usually no immunoreactive tumor cells at all could be demonstrated, showing that SP is among the peptides vulnerable to poor histotechniques.	Paraffin	28-36	tachykinin precursor 1	Homo sapiens	156-158
2409790-1	1985	An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers.	Paraffin	154-162	enolase 2	Homo sapiens	28-51
3900142-1	1985	Paraffin sections from a series of 50 lymph nodes affected by Hodgkin"s disease were examined by means of the unlabelled primary antibody peroxidase-antiperoxidase method to detect those cells which contained S-100 protein.	Paraffin	0-8	S100 calcium binding protein A1	Homo sapiens	209-214
4036858-4	1985	Immunoperoxidase studies of paraffin-embedded sections (PIP) for cytoplasmic immunoglobulin showed polytypic marking in ten of these and a monotypic plasma cell population in seven.	Paraffin	28-36	prolactin induced protein	Homo sapiens	56-59
3839434-1	1985	The authors studied the occurrence of Ricinus communis agglutinin (RCA)-binding macrophage-histiocytes in paraffin-embedded tumor tissue of 38 patients with malignant lymphoma, small lymphocytic type, a tumor of low-grade malignancy.	Paraffin	106-114	agglutinin	Ricinus communis	67-70
3839434-5	1985	RCA staining of paraffin-embedded tumor tissue of the 38 cases revealed three groups of tumors: (1) tumors with numerous (greater than 10/high-power field [HPF]) stromal macrophage-histiocytes (4 patients); (2) tumors with a moderate number (4-9/HPF) of macrophage-histiocytes (5 patients); (3) tumors with rare or no (0-3/HPF) macrophage-histiocytes, or only thin, anuclear variants (29 patients).	Paraffin	16-24	agglutinin	Ricinus communis	0-3
4047467-1	1985	A 22mer oligonucleotide complementary to the rat vasopressin (AVP) mRNA was synthesized, radioactively labeled with 32P, and was applied to in situ hybridization with the mRNA on paraffin sections of the rat hypothalamus.	Paraffin	179-187	arginine vasopressin	Rattus norvegicus	62-65
2409790-1	1985	An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers.	Paraffin	154-162	enolase 2	Homo sapiens	53-56
2409790-1	1985	An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers.	Paraffin	154-162	enolase 2	Homo sapiens	147-150
6381607-2	1984	S-100 antiserum has an advantage in its ability to stain Langerhans cells in paraffin tissues.	Paraffin	77-85	S100 calcium binding protein A1	Homo sapiens	0-5
3914969-0	1985	A correlative study of alpha-1-antitrypsin and hepatitis B surface antigen in conventional paraffin sections of chronic liver diseases.	Paraffin	91-99	serpin family A member 1	Homo sapiens	23-42
2859089-4	1985	In serial paraffin sections, it was observed that SS28 was contained in the same neuronal cell bodies which also contain SS28.	Paraffin	10-18	somatostatin	Rattus norvegicus	50-54
2579517-6	1985	Anti-MAG and anti-BP both stained regenerating myelin sheaths which were very numerous in both paraffin and epon sections.	Paraffin	95-103	myelin-associated glycoprotein	Cavia porcellus	5-8
6239959-2	1984	The microscopic differentiation between type I (red) and type II (white) fibers were made by the histochemically demonstrated myosin-ATPase activity with frozen sections and also by the immunohistochemical demonstration of beta-enolase in the paraffin sections with indirect antibody method.	Paraffin	243-251	enolase 3	Homo sapiens	223-235
6088038-0	1984	HNK-1-defined antigen detected in paraffin-embedded neuroectoderm tumors and those derived from cells of the amine precursor uptake and decarboxylation system.	Paraffin	34-42	beta-1,3-glucuronyltransferase 1	Homo sapiens	0-5
6088038-2	1984	Immunoperoxidase staining of paraffin sections revealed that HNK-1 detects neuroectoderm-derived cancers and tumors with endocrine activity.	Paraffin	29-37	beta-1,3-glucuronyltransferase 1	Homo sapiens	61-66
6088038-3	1984	Because the antigen detected by HNK-1 is well conserved in paraffin sections, this antibody is of potential diagnostic value in routine histopathology and might help to elucidate the histogenesis of some poorly understood tumors.	Paraffin	59-67	beta-1,3-glucuronyltransferase 1	Homo sapiens	32-37
3860824-0	1985	Immunocytochemical staining of estrogen receptor in paraffin sections of human breast cancer by use of monoclonal antibody: comparison with that in frozen sections.	Paraffin	52-60	estrogen receptor 1	Homo sapiens	31-48
3860824-1	1985	Estrogen receptor (ER) in human breast cancer tissues was demonstrated in paraffin sections as well as in frozen sections by immunoperoxidase methods using monoclonal antibody (H222) against ER.	Paraffin	74-82	estrogen receptor 1	Homo sapiens	0-17
3860824-1	1985	Estrogen receptor (ER) in human breast cancer tissues was demonstrated in paraffin sections as well as in frozen sections by immunoperoxidase methods using monoclonal antibody (H222) against ER.	Paraffin	74-82	estrogen receptor 1	Homo sapiens	19-21
3860824-4	1985	The specific staining for ER was located exclusively in the nuclei of cancer cells in both paraffin and frozen sections.	Paraffin	91-99	estrogen receptor 1	Homo sapiens	26-28
3860824-7	1985	The results of immunocytochemical staining agreed with those of the dextran-coated charcoal assay in 89 (82%) of the 109 paraffin-sectioned tumor tissues and in 24 (86%) of the 28 frozen-sectioned tissues, indicating that ER can be demonstrated immunocytochemically by use of paraffin as well as frozen sections.	Paraffin	276-284	estrogen receptor 1	Homo sapiens	222-224
3887834-0	1985	Immunohistochemical studies on human brain tumors using anti-Leu 7 monoclonal antibody in paraffin-embedded specimens.	Paraffin	90-98	beta-1,3-glucuronyltransferase 1	Homo sapiens	61-66
3887834-1	1985	Using the four-step peroxidase-antiperoxidase (PAP) method, the presence of the antigen recognized with anti-Leu 7 monoclonal antibody was investigated in paraffin-embedded human brain tissue and tumors.	Paraffin	155-163	beta-1,3-glucuronyltransferase 1	Homo sapiens	109-114
3931406-0	1985	Immunohistochemical demonstration of carbonic anhydrase III and muscle-specific enolase in paraffin-embedded human skeletal muscle sections.	Paraffin	91-99	carbonic anhydrase 3	Homo sapiens	37-59
3931406-0	1985	Immunohistochemical demonstration of carbonic anhydrase III and muscle-specific enolase in paraffin-embedded human skeletal muscle sections.	Paraffin	91-99	enolase 3	Homo sapiens	64-87
6388311-6	1984	In normal pancreatic ducts, there was nonspecific cross-reacting antigen (NCA) or CEA-related substances containing antigenic determinants common to NCA, which were observed more easily in frozen sections than in paraffin sections.	Paraffin	213-221	CEA cell adhesion molecule 4	Homo sapiens	38-78
6388311-6	1984	In normal pancreatic ducts, there was nonspecific cross-reacting antigen (NCA) or CEA-related substances containing antigenic determinants common to NCA, which were observed more easily in frozen sections than in paraffin sections.	Paraffin	213-221	CEA cell adhesion molecule 3	Homo sapiens	82-85
6370192-1	1984	A peroxidase-antiperoxidase immunohistochemical method was used to detect the presence of intracellular and extracellular apolipoprotein B (apo B) in paraffin sections of human abdominal aortas and coronary arteries with and without atherosclerotic involvement.	Paraffin	150-158	apolipoprotein B	Homo sapiens	122-138
6090626-1	1984	The neuroendocrine marker neuron-specific enolase (NSE) has been reported to be detectable by immunohistochemistry in paraffin sections of neuroendocrine neoplasms of the lung.	Paraffin	118-126	enolase 2	Homo sapiens	26-49
6090626-1	1984	The neuroendocrine marker neuron-specific enolase (NSE) has been reported to be detectable by immunohistochemistry in paraffin sections of neuroendocrine neoplasms of the lung.	Paraffin	118-126	enolase 2	Homo sapiens	51-54
6478264-3	1984	Paraffin sections were reacted with the antiserum to purified chick duodenal calcium-binding protein.	Paraffin	0-8	calcium-binding protein	Gallus gallus	77-100
6427296-0	1984	Effects of fixation and enzymatic digestion on the immunohistochemical demonstration of laminin and fibronectin in paraffin embedded tissue.	Paraffin	115-123	fibronectin 1	Homo sapiens	100-111
6427296-1	1984	The effects of different fixatives and enzymatic digestion procedures on the immunohistochemical demonstration of fibronectin and laminin in paraffin embedded tissues have been compared.	Paraffin	141-149	fibronectin 1	Homo sapiens	114-125
6207141-1	1984	Leu 7 immunoreactivity was demonstrated with the indirect peroxidase-labelled antibody method on frozen and paraffin-embedded tissue sections of human digestive organs.	Paraffin	108-116	beta-1,3-glucuronyltransferase 1	Homo sapiens	0-5
6380184-3	1984	Positive reactions to carcinoembryonic antigen (CEA) were demonstrated in the tumor cells in the CSF sample as well as in the paraffin-embedded section of the primary rectal cancer.	Paraffin	126-134	CEA cell adhesion molecule 3	Homo sapiens	22-46
6380184-3	1984	Positive reactions to carcinoembryonic antigen (CEA) were demonstrated in the tumor cells in the CSF sample as well as in the paraffin-embedded section of the primary rectal cancer.	Paraffin	126-134	CEA cell adhesion molecule 3	Homo sapiens	48-51
6145741-0	1984	Optimization of tyrosine hydroxylase immunocytochemistry in paraffin sections using pretreatment with proteolytic enzymes.	Paraffin	60-68	tyrosine hydroxylase	Homo sapiens	16-36
6145741-1	1984	Immunocytochemical localization of tyrosine hydroxylase (TH) was performed on paraffin sections pretreated with various proteolytic enzymes.	Paraffin	78-86	tyrosine hydroxylase	Homo sapiens	35-55
6145741-1	1984	Immunocytochemical localization of tyrosine hydroxylase (TH) was performed on paraffin sections pretreated with various proteolytic enzymes.	Paraffin	78-86	tyrosine hydroxylase	Homo sapiens	57-59
6210326-2	1984	Cases of basal cell and squamous cell carcinoma were evaluated for the presence of involucrin using immunoperoxidase techniques on paraffin sections.	Paraffin	131-139	involucrin	Homo sapiens	83-93
6425959-1	1984	In the hippocampus formation of Bouin fixed and paraffin embedded specimens of Wistar rats somatostatin-immunoreactive cells could be demonstrated regularly in the hilus region.	Paraffin	48-56	somatostatin	Rattus norvegicus	91-103
6141004-1	1984	The expression of the carbohydrate structure defined by monoclonal antibody to murine stage-specific embryonic antigen 1 (SSEA-1) was examined, using immunofluorescence, in formalin-fixed, paraffin-embedded sections of normal fetal and adult human colon and human colonic adenocarcinoma.	Paraffin	189-197	fucosyltransferase 4	Mus musculus	122-128
6366091-5	1984	Immunoperoxidase staining of CEA (PAP method) was carried out using formalin-fixed paraffin embedded sections of 37 tumors.	Paraffin	83-91	CEA cell adhesion molecule 3	Homo sapiens	29-32
6310227-1	1983	Two hundred and two benign and malignant soft tissue lesions were studied for the presence of S-100 protein by means of the peroxidase-antiperoxidase technique on formalin-fixed, paraffin-embedded tissue.	Paraffin	179-187	S100 calcium binding protein A1	Homo sapiens	94-99
6195296-2	1983	Most tumor lines and paraffin-embedded tumors and normal tissues of neuroectodermal origin were specifically stained by HNK-1.	Paraffin	21-29	beta-1,3-glucuronyltransferase 1	Homo sapiens	120-125
6373974-3	1983	Lysozyme was detected with formalin-fixed, paraffin-embedded materials in 82 cases of synovial tissue (RA 50 cases, non-RA 32 cases) using the unlabelled peroxidase anti-peroxidase (PAP) method following Taylor, et al.	Paraffin	43-51	lysozyme	Homo sapiens	0-8
6195449-10	1983	Patterns of localization of involucrin in paraffin and frozen sections were compared with staining for cytokeratins in parallel sections.	Paraffin	42-50	involucrin	Homo sapiens	28-38
6874280-1	1983	The authors sought S-100 protein in sections cut from formalin- or glutaraldehyde-fixed, paraffin-embedded tumors from the eye and other sites by an immunoperoxidase technique, using rabbit antibovine S-100 protein antiserum, swine antirabbit serum, a peroxidase-antiperoxidase preparation, and amino-ethylcarbizole as developer.	Paraffin	89-97	S100 calcium binding protein A1	Homo sapiens	19-24
6355996-0	1983	Immunohistochemical detection of fibronectin using different fixatives in paraffin embedded sections.	Paraffin	74-82	fibronectin 1	Homo sapiens	33-44
6310427-3	1983	With antisera to the human enzyme, CE is demonstrated in paraffin sections on the apical surface of epithelial cells in the proximal tubule of the kidney, the mucosa of the small intestine, the syncytial trophoblast of the placenta, and the choroid plexus.	Paraffin	57-65	angiotensin I converting enzyme	Homo sapiens	35-37
6862625-5	1983	Immunoreactive Fn was detected in paraffin-stimulated whole saliva by enzyme-linked immunosorbent assays of saliva adsorbed onto gelatin-coated cuvettes and by immunoelectroblots (Western blots) of salivary components separated on sodium dodecyl sulfate-polyacrylamide slab gels.	Paraffin	34-42	fibronectin 1	Homo sapiens	15-17
6344800-2	1983	The cellular localization of glial S-100 protein was investigated in paraffin-embedded sections of cutaneous histiocytosis X and in a variety of cutaneous infiltrative disorders, including juvenile xanthogranuloma, necrobiotic xanthogranuloma, papular xanthoma, eruptive histiocytoma, and reticulohistiocytosis.	Paraffin	69-77	S100 calcium binding protein A1	Homo sapiens	35-40
6350232-4	1983	Using this antiserum and antisera to lysozyme and alpha-1-anti-trypsin we have stained paraffin sections of tissues containing reactive histiocytes, histiocytic proliferations, leukaemic infiltrates and lymphoreticular tumours of histiocytic and T-cell origin.	Paraffin	87-95	lysozyme	Homo sapiens	37-45
6347863-2	1983	We report the distribution of immunoreactive renin in the tumour visualized by light microscopy of both paraffin and resin embedded tissue sections.	Paraffin	104-112	renin	Homo sapiens	45-50
6347490-1	1983	Alpha-1-antitrypsin detected by immunoperoxidase has been used as a marker for infiltrating monocytes on formalin-fixed, paraffin-embedded sections of 75 renal biopsies.	Paraffin	121-129	serpin family A member 1	Homo sapiens	0-19
6341008-1	1983	CEA was studied in paraffin sections from 50 cases of colonic and 50 cases of gastric adenocarcinoma using immunoperoxidase and immunofluorescence techniques.	Paraffin	19-27	CEA cell adhesion molecule 3	Homo sapiens	0-3
6188883-1	1983	Bronchial endocrine cells containing gastrin-releasing peptide (GRP), a mammalian analog of bombesin, and adrenocorticotropic hormone (ACTH) were immunohistochemically localized in paraffin sections of normal and pathologic human lungs.	Paraffin	181-189	proopiomelanocortin	Homo sapiens	135-139
6339267-2	1983	Preliminary trypsinization of paraffin sections is necessary to unmask the immunoreactive lysozyme.	Paraffin	30-38	lysozyme	Homo sapiens	90-98
6301296-1	1982	The presence of S-100 protein was immunohistochemically studied in many types of formalin-fixed and paraffin-embedded tumors (260 cases).	Paraffin	100-108	S100 calcium binding protein A1	Homo sapiens	16-21
6184382-4	1982	Paraffin sections of cerebrum, brainstem, and spinal cord were immunostained with antisera to MAG and BP.	Paraffin	0-8	myelin-associated glycoprotein	Rattus norvegicus	94-97
6752046-1	1982	We sought S-100 protein in sections prepared from formalin-fixed paraffin-embedded tumor and normal tissues by an immunoperoxidase technique with a rabbit anti-bovine S-100 protein antiserum as first antibody and aminoethyl carbazole as developer.	Paraffin	65-73	S100 calcium binding protein A1	Homo sapiens	10-15
6182184-2	1982	Under light microscopy, the AFP-containing hepatocytes were successfully demonstrated in paraffin-embedded liver tissues fixed with 4% paraformaldehyde(PFA)-picric acid solution containing 0.5% glutaraldehyde (GA).	Paraffin	89-97	alpha fetoprotein	Homo sapiens	28-31
6297236-1	1982	Distribution of intracytoplasmic lysozyme in proliferative and neoplastic fibrohistiocytic lesions and non fibrohistiocytic tumors was studied by immunoperoxidase technique on formalin fixed, paraffin-embedded sections.	Paraffin	192-200	lysozyme	Homo sapiens	33-41
6801111-1	1982	The immunohistochemical detection of factor VIII/von Willebrand factor antigen (FVIII/vWF-AG) in formalin-fixed paraffin-embedded tissues was investigated using the peroxidase-antiperoxidase (PAP) method.	Paraffin	112-120	von Willebrand factor	Homo sapiens	86-89
6807528-1	1982	The presence of nervous tissue specific S100 protein was studied immunohistochemically in 47 cases of malignant melanoma and 25 pigmented nevi of various types of peroxidase-antiperoxidase immunoenzyme method on routine paraffin sections of the surgical specimens.	Paraffin	220-228	S100 calcium binding protein A1	Homo sapiens	40-44
6752789-1	1982	The carcinoembryonic antigen (CEA) was studied in paraffin sections of 114 benign breast lesions and in 65 tumor-bearing breasts using the indirect immune peroxidase technique.	Paraffin	50-58	CEA cell adhesion molecule 3	Homo sapiens	4-28
6752789-1	1982	The carcinoembryonic antigen (CEA) was studied in paraffin sections of 114 benign breast lesions and in 65 tumor-bearing breasts using the indirect immune peroxidase technique.	Paraffin	50-58	CEA cell adhesion molecule 3	Homo sapiens	30-33
7178763-1	1982	Lysozyme-producing cells were analysed by enzyme histochemistry in paraffin sections of synovial tissue of 60 patients with rheumatoid arthritis (RA) and 20 patients with osteoarthritis (OA).	Paraffin	67-75	lysozyme	Homo sapiens	0-8
6294975-0	1982	Demonstration of alpha 1-antitrypsin in paraffin sections of hepatoma and cirrhosis.	Paraffin	40-48	serpin family A member 1	Homo sapiens	17-36
7346797-1	1981	The presence of CEA was studied in paraffin sections of 100 benign breast lesions using an immunoperoxidase technique.	Paraffin	35-43	CEA cell adhesion molecule 3	Homo sapiens	16-19
6807709-0	1982	Demonstration of carcinoembryonic antigen (CEA) by means of the immunoperoxidase technique in paraffin-embedded specimens of tumour tissues.	Paraffin	94-102	CEA cell adhesion molecule 3	Homo sapiens	17-41
6807709-0	1982	Demonstration of carcinoembryonic antigen (CEA) by means of the immunoperoxidase technique in paraffin-embedded specimens of tumour tissues.	Paraffin	94-102	CEA cell adhesion molecule 3	Homo sapiens	43-46
6807709-1	1982	The unlabelled antibody-enzyme method with the peroxidase-antiperoxidase complex (PAP-complex) was used to demonstrate carcinoembryonic antigen (CEA) or CEA-like substances in paraffin-embedded specimens of tumour tissues with an anti-CEA-antiserum of a rabbit.	Paraffin	176-184	CEA cell adhesion molecule 3	Homo sapiens	119-143
6807709-1	1982	The unlabelled antibody-enzyme method with the peroxidase-antiperoxidase complex (PAP-complex) was used to demonstrate carcinoembryonic antigen (CEA) or CEA-like substances in paraffin-embedded specimens of tumour tissues with an anti-CEA-antiserum of a rabbit.	Paraffin	176-184	CEA cell adhesion molecule 3	Homo sapiens	145-148
6807709-1	1982	The unlabelled antibody-enzyme method with the peroxidase-antiperoxidase complex (PAP-complex) was used to demonstrate carcinoembryonic antigen (CEA) or CEA-like substances in paraffin-embedded specimens of tumour tissues with an anti-CEA-antiserum of a rabbit.	Paraffin	176-184	CEA cell adhesion molecule 3	Homo sapiens	153-156
6807709-1	1982	The unlabelled antibody-enzyme method with the peroxidase-antiperoxidase complex (PAP-complex) was used to demonstrate carcinoembryonic antigen (CEA) or CEA-like substances in paraffin-embedded specimens of tumour tissues with an anti-CEA-antiserum of a rabbit.	Paraffin	176-184	CEA cell adhesion molecule 3	Homo sapiens	153-156
6275815-5	1981	The short carbon chain paraffins with a high degree of chlorination increased the concentration of liver microsomal cytochrome P-450, inhibited the metabolism of 7-ethoxyresorufin but increased the metabolism of benzo(a)pyrene, especially the formation of the 4,5-diol metabolite.	Paraffin	23-32	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	116-132
6167343-1	1981	Paraffin-embedded tissues from 15 women with breast or endometrial carcinomas were analyzed in a study designed to explore the possible value and validity of an immunoperoxidase method for the detection of estrogen receptor in formalin-fixed paraffin-embedded tissue.	Paraffin	242-250	estrogen receptor 1	Homo sapiens	206-223
6168166-4	1981	The tumor tissues of the paraffin sections revealed a bright positive fluorescence for AFP with indirect immunofluorescence method.	Paraffin	25-33	alpha fetoprotein	Homo sapiens	87-90
6793028-0	1981	Effects of polychlorinated terphenyls and paraffins on rat liver microsomal cytochrome P-450 and in vitro metabolic activities.	Paraffin	42-51	cytochrome P450, family 2, subfamily g, polypeptide 1	Rattus norvegicus	76-92
7002956-1	1980	The distribution of fibronectin in 42 renal biopsies was investigated using an indirect immunoperoxidase technique on paraffin sections of formalin-fixed material.	Paraffin	118-126	fibronectin 1	Homo sapiens	20-31
6161618-2	1980	An immunoperoxidase procedure was used to localize the apolipoprotein B in the atherosclerotic lesions of vein grafts removed 5 years after an aortocoronary bypass operation and preserved by embedding in paraffin.	Paraffin	204-212	apolipoprotein B	Homo sapiens	55-71
7008496-3	1980	On comparing frozen sections of unfixed material with paraffin sections of formalin fixed material a slightly better preservation of the immunoreactivity of AAT was observed in frozen sections.	Paraffin	54-62	serpin family A member 1	Homo sapiens	157-160
7008496-10	1980	It is concluded that for the immunohistochemical demonstration of AAT in liver tissue the employment of indirect immunoperoxidase staining on formalin fixed, paraffin embedded material is recommendable as it combines a sensitive staining technique with a satisfactory preservation of immunoreactivity and tissue morphology.	Paraffin	158-166	serpin family A member 1	Homo sapiens	66-69
91477-1	1979	Using the indirect immunoperoxidase method, alpha 1-fetoprotein (AFP) can be demonstrated in paraffin sections of tumours by light-microscopy.	Paraffin	93-101	alpha fetoprotein	Homo sapiens	44-63
7001480-1	1980	By use of the indirect peroxidase-antiperoxidase complex immunocytochemical technique, antibody to purified human renal renin was applied to formalin-fixed paraffin sections of human cadaver brain.	Paraffin	156-164	renin	Homo sapiens	120-125
6772608-0	1980	Immunoperoxidase localisation of fibronectin in glomeruli of formalin fixed paraffin processed renal tissue.	Paraffin	76-84	fibronectin 1	Homo sapiens	33-44
6772608-1	1980	An indirect immunoperoxidase technique was used to demonstrate fibronectin in sections of routine formalin fixed paraffin embedded renal tissue.	Paraffin	113-121	fibronectin 1	Homo sapiens	63-74
7002391-3	1980	In indirect immunofluorescence on paraffin sections of bovine pituitary glands the antibodies could be used for the detection of PRL-producing cells.	Paraffin	34-42	prolactin	Bos taurus	129-132
6251326-2	1980	In these 20 cases alpha 1-antitrypsin was demonstrated in paraffin sections by a modification of the indirect peroxidase-antiperoxidase method.	Paraffin	58-66	serpin family A member 1	Homo sapiens	18-37
389221-1	1979	An immunoperoxidase technique was applied to the localization of IgE in formaldehyde-solution-fixed, paraffin-embedded tissue.	Paraffin	101-109	immunoglobulin heavy constant epsilon	Homo sapiens	65-68
91477-1	1979	Using the indirect immunoperoxidase method, alpha 1-fetoprotein (AFP) can be demonstrated in paraffin sections of tumours by light-microscopy.	Paraffin	93-101	alpha fetoprotein	Homo sapiens	65-68
86522-1	1979	Carcinoembryonic antigen (CEA) was studied by the indirect triple-bridge immunoperoxidase method in formalin-fixed paraffin-embedded tissue specimens from 191 patients with premalignant epithelial lesions or epidermoid carcinoma of the uterine cervix treated 12 years ago.	Paraffin	115-123	CEA cell adhesion molecule 3	Homo sapiens	0-24
225005-2	1979	Indirect immunofluorescent staining for CEA was carried out on formalin-fixed paraffin-embedded sections, and the slides were examined under code.	Paraffin	78-86	CEA cell adhesion molecule 3	Homo sapiens	40-43
378175-1	1979	An indirect immunoperoxidase technique was used to study the content and distribution of IgE in formaldehyde solution-fixed, paraffin-embedded adenoid and nasal tissues of atopic and nonatopic persons.	Paraffin	125-133	immunoglobulin heavy constant epsilon	Homo sapiens	89-92
93568-2	1979	As an extension of this work, the same approach was used to test for and to localize prolactin binding sites in autopsy and biopsy specimens of formalin fixed, paraffin embedded human prostate.	Paraffin	160-168	prolactin	Homo sapiens	85-94
86522-1	1979	Carcinoembryonic antigen (CEA) was studied by the indirect triple-bridge immunoperoxidase method in formalin-fixed paraffin-embedded tissue specimens from 191 patients with premalignant epithelial lesions or epidermoid carcinoma of the uterine cervix treated 12 years ago.	Paraffin	115-123	CEA cell adhesion molecule 3	Homo sapiens	26-29
365699-1	1978	An immunoperoxidase technique for the histological demonstration of Carcinoembryonic Antigen (CEA) was applied to paraffin sections from 74 breast carcinomas and 43 benign breast lesions.	Paraffin	114-122	CEA cell adhesion molecule 3	Homo sapiens	68-92
383819-0	1979	Demonstration of alpha 1-antitrypsin by immunofluorescence on paraffin-embedded hepatic and pancreatic tissue.	Paraffin	62-70	serpin family A member 1	Homo sapiens	17-36
383819-1	1979	Studies were performed in an attempt to improve current immunohistological techniques for the demonstration of alpha 1-antitrypsin (A1AT) in formalin-fixed paraffin-embedded tissues.	Paraffin	156-164	serpin family A member 1	Homo sapiens	111-130
383819-1	1979	Studies were performed in an attempt to improve current immunohistological techniques for the demonstration of alpha 1-antitrypsin (A1AT) in formalin-fixed paraffin-embedded tissues.	Paraffin	156-164	serpin family A member 1	Homo sapiens	132-136
288181-1	1979	The lysozyme activity was determined in paraffin stimulated whole saliva from 51 randomly selected children.	Paraffin	40-48	lysozyme	Homo sapiens	4-12
365699-1	1978	An immunoperoxidase technique for the histological demonstration of Carcinoembryonic Antigen (CEA) was applied to paraffin sections from 74 breast carcinomas and 43 benign breast lesions.	Paraffin	114-122	CEA cell adhesion molecule 3	Homo sapiens	94-97
209658-1	1978	Eighty glial and non-glial brain tumors have been studied to date using an immunologically specific and highly sensitive method of staining GFA protein which is applicable to formalin fixed and paraffin embedded tissue.	Paraffin	194-202	glutamine--fructose-6-phosphate transaminase 1	Homo sapiens	140-143
361205-1	1978	Carcinoembryonic antigen (CEA) was demonstrated in formalin-fixed paraffin embedded sections of normal small intestine using an immunoperoxidase method.	Paraffin	66-74	CEA cell adhesion molecule 3	Homo sapiens	0-30
80416-0	1978	Immunostaining of growth hormone and prolactin in paraffin-embedded and stored or previously stained materials.	Paraffin	50-58	growth hormone 1	Homo sapiens	18-32
80416-0	1978	Immunostaining of growth hormone and prolactin in paraffin-embedded and stored or previously stained materials.	Paraffin	50-58	prolactin	Homo sapiens	37-46
361759-10	1978	Trypsinised paraffin sections were, however, more suitable for intracellular Ig (c-Ig) than cryostat sections although the performance of cryostat sections could be improved by prior fixation with a coagulative fixative.	Paraffin	12-20	fibronectin 1	Homo sapiens	81-85
369084-3	1978	It thus appears that the incidence of positive CEA by immunoperoxidase staining of formalin-fixed, paraffin-embedded tumour tissue sections is much less than the frequency of blood or urinary CEA elevations in patients with urothelial cancer.	Paraffin	99-107	CEA cell adhesion molecule 3	Homo sapiens	47-50
204415-1	1978	Alpha-1-antitrypsin was demonstrated both by immunofluorescence and immunoperoxidase techniques in the peripheral islet cells of 15 normal human pancreases, processed freshly and after embedding in paraffin.	Paraffin	198-206	serpin family A member 1	Homo sapiens	0-19
337999-1	1977	Cellular localization of carcinoembryonic antigen (CEA) in medullary thyroid carcinoma was studied in ethanol-fixed, paraffin-embedded specimens using the direct and indirect immunofluorescent techniques.	Paraffin	117-125	CEA cell adhesion molecule 3	Homo sapiens	25-49
319818-2	1977	CEA was demonstrated in a higher percentage of the polyps received as fresh specimens that were rapidly frozen and fixed in ethanol, than in formalin-fixed, paraffin-embedded sections.	Paraffin	157-165	CEA cell adhesion molecule 3	Homo sapiens	0-3
338442-1	1977	An immunoperoxidase method for the demonstration of carcinoembryonic antigen (CEA) in tissues was applied to formalin-fixed paraffin embedded and glutaraldehyde-fixed resin sections of normal human small intestine.	Paraffin	124-132	CEA cell adhesion molecule 3	Homo sapiens	52-76
63319-3	1976	An indirect immunoperoxidase method for the localization of human chorionic gonadotropin (HCG) and alpha-fetoprotein (AFP) was done on formalin-fixed paraffin-embedded tissue from 10 neoplasms; HCG was present in all 10 neoplasms, and AFP was found in seven.	Paraffin	150-158	alpha fetoprotein	Homo sapiens	118-121
67737-1	1977	A modification of Wilson"s crystal violet staining for renin granules is able to show both centra and peripheral nerve fibres on paraffin sections with reproducible results.	Paraffin	129-137	renin	Homo sapiens	55-60
1237519-4	1975	This immunocytochemical method for demonstrating the presence of CEA functioned in both frozen, ethanol-fixed and formalin-fixed, paraffin-embedded tissues, thus making it applicable for use with tissue sections conventionally prepared for light microscopy.	Paraffin	130-138	CEA cell adhesion molecule 3	Homo sapiens	65-68
61690-1	1976	CEA activity was studied using a three-layer bridge immunoperoxidase method in paraffin-embedded histological sections of gastric mucosa from patients with gastric cancer and from normal asymptomatic subjects.	Paraffin	79-87	CEA cell adhesion molecule 3	Homo sapiens	0-3
794493-8	1976	An analysis of the formalin-paraffin-treated sections showed that immunoperoxidase-tested CEA positivity reflected CEA levels in tissue of at least 3.0-5.0 mug/g; this permitted retrospective estimates of minimal tissue CEA concentrations in older histopathologic specimens by the immunoperoxidase reaction method.	Paraffin	28-36	CEA cell adhesion molecule 3	Homo sapiens	90-93
794493-9	1976	Formalin-paraffin-treated sections as old as 10 years still had demonstrable CEA.	Paraffin	9-17	CEA cell adhesion molecule 3	Homo sapiens	77-80
1100679-0	1975	Immunofluorescent detection of alpha1-antitrypsin in paraffin embedded liver tissue.	Paraffin	53-61	serpin family A member 1	Homo sapiens	31-49
1100679-8	1975	These findings prove that paraffin embedded specimens are suitable for immunofluorescence detection of alpha1-antitrypsin and that a retrospective study on old paraffin blocks is possible.	Paraffin	26-34	serpin family A member 1	Homo sapiens	103-121
13947535-0	1963	Adsorbed films of bovine serum albumin: tensions at air-water surfaces and paraffin-water interfaces.	Paraffin	75-83	albumin	Homo sapiens	25-38
33675071-5	2021	The expression of tRF-Pro-CGG in paraffin-embedded tissues was detected by fluorescence in situ hybridization (FISH).	Paraffin	33-41	telomeric repeat binding factor 1	Homo sapiens	18-21
33957888-4	2021	METHODS: We used immunohistochemistry and qPCR, respectively, to detect p16 and HPV DNA in archrival formalin-fixed paraffin-embedded HNSCC tissues.	Paraffin	116-124	cyclin dependent kinase inhibitor 2A	Homo sapiens	72-75
33443847-11	2021	IHC is a reliable test for identifying the BRAF V600E mutation in ameloblastomas, presenting advantages such as being more frequently used in surgical pathology laboratories and requiring fewer critical steps for paraffin-embedded tissue compared with molecular biology techniques.	Paraffin	213-221	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	43-47
33290179-7	2021	METHODS: mIF staining was performed with formalin-fixed, paraffin-embedded slides from 10 patients with iLTS who underwent cricotracheal resection and 10 control specimens derived from rapid autopsy for CD4, CD8, CD20, FoxP3, PD-1, PD-L1, and cytokeratin.	Paraffin	57-65	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	9-12
33993060-7	2021	In this study, we have identified 44 (26.19 %) NOTCH1 gene mutations from a whole-exome sequencing of 168 OSCC formalin-fixed, paraffin-embedded (FFPE) tissue specimen.	Paraffin	127-135	notch receptor 1	Homo sapiens	47-53
33739392-6	2021	COL5A2 was upregulated in GC tissues by paraffin immunohistochemistry and RT-qPCR.	Paraffin	40-48	collagen type V alpha 2 chain	Homo sapiens	0-6
33893247-6	2021	The accuracy of ERBB2 copy number variations in tissue/formalin-fixed and paraffin-embedded samples was 95% with 86% sensitivity and 99% specificity.	Paraffin	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-21
33996912-4	2021	Here, we describe the use of mIF tyramide signal amplification for labeling up to eight markers on a single slide of formalin-fixed, paraffin-embedded tumor tissue to phenotype immune cells in tumor tissues.	Paraffin	133-141	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	29-32
32964396-5	2021	Immunostaining of 100 cases of astrocytomas for PELP1 was performed on paraffin-embedded sections.	Paraffin	71-79	proline, glutamate and leucine rich protein 1	Homo sapiens	48-53
33895166-4	2021	METHODS: We used immunohistochemistry to visualise loss of the cancer driver KDM6A in formalin-fixed paraffin embedded (FFPE) normal human colonic epithelium.	Paraffin	101-109	lysine demethylase 6A	Homo sapiens	77-82
33902956-6	2021	TSC1/2 expression levels in paraffin-embedded tissues were determined by immunohistochemistry (IHC) and then analyzed as subgroups.	Paraffin	28-36	TSC complex subunit 1	Homo sapiens	0-6
33656690-5	2021	METHODS: Plexin C1 overexpression was evaluated immunohistochemically on paraffin-embedded blocks of the HCC patients.	Paraffin	73-81	plexin C1	Homo sapiens	9-18
33751222-5	2021	Here we report a case of systemic apolipoprotein A-IV-associated amyloidosis that was confirmed by proteome analysis using formalin-fixed paraffin-embedded tissue and an immunohistochemical technique.	Paraffin	138-146	apolipoprotein A4	Homo sapiens	34-53
33675181-6	2021	Expression of Notch1 receptor and NICD1 was evaluated by immunohistochemistry on formalin fixed paraffin embedded tissues.	Paraffin	96-104	notch receptor 1	Homo sapiens	14-20
33759071-4	2022	This study contained two cohorts: in cohort A, AQP9 protein expression (from formalin fixed paraffin embedded tumor and paired adjacent tissue specimens) in 198 patients was detected by immunohistochemistry (IHC).	Paraffin	92-100	aquaporin 9	Homo sapiens	47-51
33710124-3	2021	Preliminary studies in our laboratory found low immunostaining for the NeuN antibody on formalin fixed and paraffin embedded (FFPE) human brain tissue.	Paraffin	107-115	RNA binding fox-1 homolog 3	Homo sapiens	71-75
33208670-5	2021	Albumin mRNA detection was performed using RNAscope run on formalin-fixed, paraffin-embedded tissue sections.	Paraffin	75-83	albumin	Homo sapiens	0-7
33561783-4	2021	METHODS: Expression of urokinase plasminogen activator receptor (uPAR) and epithelial cell adhesion molecule (EpCAM) are determined on paraffin-embedded human UCC using immunohistochemistry and on UCC cell lines by flow cytometry.	Paraffin	135-143	epithelial cell adhesion molecule	Homo sapiens	75-108
33561783-4	2021	METHODS: Expression of urokinase plasminogen activator receptor (uPAR) and epithelial cell adhesion molecule (EpCAM) are determined on paraffin-embedded human UCC using immunohistochemistry and on UCC cell lines by flow cytometry.	Paraffin	135-143	epithelial cell adhesion molecule	Homo sapiens	110-115
33597223-4	2022	The automated Idylla epidermal growth factor receptor (EGFR) mutation test has been developed to rapidly process formalin-fixed paraffin-embedded (FFPE) pathologic material, without previous DNA extraction.	Paraffin	128-136	epidermal growth factor receptor	Homo sapiens	21-53
33574923-5	2021	The expression of Twist, Slug and Snail in 229 paraffin-embedded ESCC and matched normal mucosal tissues was detected by immunohistochemistry.	Paraffin	47-55	twist family bHLH transcription factor 1	Homo sapiens	18-23
33631924-6	2021	Proteins of interest, including PRDX2, PRDX6, and Gelsolin, were differentially expressed in chemo-sensitive tumors versus chemo-resistant tissues and these observations were validated by immunohistochemistry in 92 formalin-fixed and paraffin-embedded (FFPE) specimens.	Paraffin	234-242	peroxiredoxin 2	Homo sapiens	32-37
33597223-4	2022	The automated Idylla epidermal growth factor receptor (EGFR) mutation test has been developed to rapidly process formalin-fixed paraffin-embedded (FFPE) pathologic material, without previous DNA extraction.	Paraffin	128-136	epidermal growth factor receptor	Homo sapiens	55-59
33572647-6	2021	The expression of PARP1 was also assessed by immunohistochemistry in formalin-fixed paraffin-embedded tissues of 128 primary cutaneous melanoma patients and correlated with follow-up and clinicopathologic features.	Paraffin	84-92	poly(ADP-ribose) polymerase 1	Homo sapiens	18-23
33547330-5	2021	The SNP rs2234693 in the ESR1 gene was genotyped on DNA from formalin-fixed paraffin embedded (FFPE) tumor tissue using Taqman assays and related to the primary endpoint disease-free survival (DFS) and secondary endpoint overall survival (OS).	Paraffin	76-84	estrogen receptor 1	Homo sapiens	25-29
33683683-0	2021	Automated Immunohistochemistry Assay for the Detection of Napsin-A in Formalin-Fixed Paraffin-Embedded Tissues from Lung Tumors.	Paraffin	85-93	napsin A aspartic peptidase	Homo sapiens	58-66
33413574-2	2021	We illustrate how multiplex immunofluorescence (mIF) combined with statistical modeling can be used to precisely estimate dynamic changes in sTIL score, PD-L1 expression, and other immune variables from a single paraffin-embedded slide, thus enabling comprehensive characterization of activity of novel immunotherapy agents.	Paraffin	212-220	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	48-51
33280268-1	2021	BACKGROUND: Human epidermal growth factor receptor 2-in situ hybridization (HER2-ISH) is widely approved for diagnostic, prognostic biomarker testing of formalin-fixed paraffin-embedded tissue blocks.	Paraffin	168-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-52
33280268-1	2021	BACKGROUND: Human epidermal growth factor receptor 2-in situ hybridization (HER2-ISH) is widely approved for diagnostic, prognostic biomarker testing of formalin-fixed paraffin-embedded tissue blocks.	Paraffin	168-176	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-80
33631963-6	2021	Next-generation sequencing (NGS) was performed on formalin-fixed paraffin-embedded tumor tissue, revealing one mutation in exon 5, TP53: p.A159 V, which may be associated with chemo-resistance.	Paraffin	65-73	tumor protein p53	Homo sapiens	131-135
33403038-6	2021	Immunohistochemical (IHC) staining was used to detect TC2N protein expression in Paraffin-embedded tissues in our center.	Paraffin	81-89	tandem C2 domains, nuclear	Homo sapiens	54-58
32358715-2	2020	The goal of this meta-analysis was to perform a systematic review of studies using the VE1 clone (specific for detection of the BRAF V600E mutation) on formalin-fixed paraffin embedded (FFPE) thyroid surgical resection specimens for primary papillary thyroid carcinoma.	Paraffin	167-175	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	128-132
33357312-5	2020	Among them, 132 patients with relatively complete clinical data and with EGFR gene mutation detection of paraffin-embedded pleural effusion sediment section according to the established quality control standard were included.	Paraffin	105-113	epidermal growth factor receptor	Homo sapiens	73-77
33037085-4	2021	In this study, it was observed that the expression levels of PCBP2 mRNA and protein were diametric in breast normal and cancer cell lines, paraffin-embedded and fresh tissue specimens, consistent with data from The Cancer Genome Atlas (TCGA) and the Clinical Proteomic Tumor Analysis Consortium (CPTAC).	Paraffin	139-147	poly(rC) binding protein 2	Homo sapiens	61-66
33124203-5	2021	We then used an immunohistochemical method to detect TMEM107 expression in 106 paraffin-embedded NSCLC and corresponding normal samples and analyzed its relationship with clinicopathological parameters.	Paraffin	79-87	transmembrane protein 107	Homo sapiens	53-60
32835941-6	2020	Additionally, the expression levels of E-cadherin and Vimentin were also evaluated by immunohistochemistry using the formalin-fixed paraffin embedded canine oral SCC tissues, and the results show that the expression level of Vimentin in TSCC was higher than in NTSCC.	Paraffin	132-140	vimentin	Canis lupus familiaris	225-233
33281931-6	2020	Genomic DNA was extracted from the paraffin-fixed tumour sample, and c.1504_1509dupGCCTAT (p.Ala502_Tyr503dup) mutation was detected in exon 9 of the KIT gene.	Paraffin	35-43	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	150-153
32307573-5	2020	CTNNB1-PLAG1 gene fusion was identified by reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissue (FFPE).	Paraffin	112-120	PLAG1 zinc finger	Homo sapiens	7-12
32891822-13	2020	IHC staining in HCC TMA further showed that the decreased of HPD in paraffin-imbedded HCC samples was linked to an adverse overall postoperative survival (p < 0.001).	Paraffin	68-76	4-hydroxyphenylpyruvate dioxygenase	Homo sapiens	61-64
33010699-6	2020	RESULTS: The results indicated that the dual-block assays significantly increased the HER2 overexpression (IHC 2+ and 3+) rate compared with the single paraffin block detection.	Paraffin	152-160	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90
33154942-9	2020	We tested P16INK4a expression on paraffin-embedded tissue sections from 9 tissue microarrays (TMAs), built with 2 mm cores derived from 133 uveal melanoma FFPE blocks, collected from 1990 to 2018, and from selected paraffin-blocks of 3 UM liver metastases.	Paraffin	33-41	cyclin dependent kinase inhibitor 2A	Homo sapiens	10-18
33659435-6	2020	In this protocol, we describe the procedure for double immunofluorescence staining of PDGFR-beta and alpha-SMA in swine Formalin-Fixed Paraffin-Embedded (FFPE) kidney biopsies and the method for image analysis and quantification.	Paraffin	135-143	platelet derived growth factor receptor alpha	Sus scrofa	86-96
33029912-6	2021	METHODS: Real-time RT-PCR was applied to evaluate hsa-miR-27a-3p and EGFR expressions in the formalin-fixed paraffin-embedded (FFPE) tissue samples obtained from 50 GBM and 50 normal people.	Paraffin	108-116	albumin	Homo sapiens	50-53
32772316-2	2020	METHODS: We designed single-molecule molecular inversion probes to target 18 MTOR somatic mutational hot-spots in unmatched, histologically proven focal cortical dysplasias from formalin-fixed, paraffin-embedded tissues of 50 patients.	Paraffin	194-202	mechanistic target of rapamycin kinase	Homo sapiens	77-81
32451170-4	2020	MATERIALS AND METHODS: TP53 was PCR amplified using the genomic DNA extracted from peripheral blood mononuclear cells and formalin-fixed, paraffin-embedded tissue sections from the tumor site of the patient, and was sequenced.	Paraffin	138-146	tumor protein p53	Homo sapiens	23-27
32621174-4	2020	We developed an amplicon-based panel to detect human epidermal receptor growth factor (HER2) amplification in formalin-fixed paraffin-embedded (FFPE) tumor tissue samples from 280 breast cancer and 50 gastric cancer patients.	Paraffin	125-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-91
32754325-2	2020	Reverse transcription-quantitative PCR was used to quantify the mRNA expression levels of HIF-1alpha, HIF-2alpha, prolyl hydroxylase (PHD)1, PHD2 and PHD3 in formalin-fixed paraffin-embedded (FFPE) tumour tissue samples from 41 patients with RCC, including 33 cases of clear cell RCC (ccRCC).	Paraffin	173-181	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
33047021-3	2020	Results show that compared with the base oil of liquid paraffin (LP), the coefficient of friction and wear rate of the BP nanosheets as the additives in liquid paraffin (BP-LP) are lower for the same loads.	Paraffin	160-168	opiorphin prepropeptide	Homo sapiens	170-175
32908618-7	2020	Results: In the paraffin sections of rat embryos, the immunohistochemical staining of RET, p75NTR, and Sox10 can all be used in demonstrating NCSCs.	Paraffin	16-24	ret proto-oncogene	Rattus norvegicus	86-89
32501574-5	2020	At the same time, the expression of WNT3 was verified by lncWNT3-IT by paraffin sectioning, fluorescence in situ hybridization, interference, overexpression, cytotoxicity assay, western blotting, and qPCR.	Paraffin	71-79	Wnt family member 3	Homo sapiens	36-40
32772147-4	2021	METHODS: In this study, for the first time, the staining pattern and clinical significance of MAGE-A2 were evaluated in 166 paraffin-embedded prostate tissues, including 148 cases of PCa and 18 cases of high-grade prostatic intraepithelial neoplasia (HPIN), by immunohistochemical analysis.	Paraffin	124-132	MAGE family member A2	Homo sapiens	94-101
32691176-8	2020	Furthermore, the presence of SS18-SSX2 fusion transcripts was confirmed by reverse transcription-polymerase chain reaction analysis, using a paraffin-embedded tumor specimen.	Paraffin	141-149	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	29-33
32416209-2	2020	Studies conducted on formalin-fixed paraffin-embedded (FFPE) tissue have found that nuclear expression of a monoclonal antibody NR4A3 (NOR-1) is a sensitive and specific diagnostic marker for ACC-SG.	Paraffin	36-44	nuclear receptor subfamily 4 group A member 3	Homo sapiens	128-133
32416209-2	2020	Studies conducted on formalin-fixed paraffin-embedded (FFPE) tissue have found that nuclear expression of a monoclonal antibody NR4A3 (NOR-1) is a sensitive and specific diagnostic marker for ACC-SG.	Paraffin	36-44	nuclear receptor subfamily 4 group A member 3	Homo sapiens	135-140
32157438-4	2020	METHODS: Immunohistochemical analysis was obtained to quantify RIP140 and LCoR expression in formalin-fixed paraffin embedded tissue sections of cervical intraepithelial neoplasia samples.	Paraffin	108-116	ligand dependent nuclear receptor corepressor	Homo sapiens	74-78
32436149-4	2020	AR status was detected by immunohistochemistry on formalin-fixed, paraffin-embedded tumoral tissue sections.	Paraffin	66-74	androgen receptor	Homo sapiens	0-2
32782703-5	2020	The c-KIT mutation at exon 11 c.1676T>C (p.V559A) was detected in the paraffin-embedded tumor tissue.	Paraffin	70-78	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-9
32774739-5	2020	Immunohistochemistry (IHC) was performed to analyze the expression of PCK2 in formalin-fixed paraffin-embedded (FFPE) tissue sections, including laryngeal squamous cell carcinoma tissues from various stages.	Paraffin	93-101	phosphoenolpyruvate carboxykinase 2 (mitochondrial)	Mus musculus	70-74
32674482-3	2020	We analyzed ERBB2 expression using a clinically applicable assay in formalin-fixed paraffin-embedded (FFPE) tumors (primary or metastatic) from a retrospective series of 77 patients with advanced HER2+ BC treated with T-DM1.	Paraffin	83-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-17
32429447-7	2020	In order to confirm this finding, we screened 38 paraffin-embedded tissue samples stage 4Sneuroblastoma for E2F3 protein expression using immunofluorescence, and we observed that augmented expression was strongly associated with impaired event-free survival.	Paraffin	49-57	E2F transcription factor 3	Homo sapiens	108-112
32560654-7	2020	mRNA for gene expression analysis of AR and steroidogenic enzymes was extracted from formalin-fixed paraffin embedded (FFPE) tissues and analyzed by real-time PCR.	Paraffin	100-108	androgen receptor	Homo sapiens	37-39
32532290-10	2020	The whole-exome sequencing identified TSC1 (c.2356C > T, p.R786*) mutation in both paraffin block tissue and blood samples.	Paraffin	83-91	TSC complex subunit 1	Homo sapiens	38-42
32566011-9	2020	HIF-1alpha expression was tested in paraffin-embedded sections using immunohistochemistry.	Paraffin	36-44	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
32671062-4	2020	The expression of CaSR protein and its relationship with pathological parameters were examined in paraffin sections from 51 LUAD patients, by immunohistochemistry.	Paraffin	98-106	calcium sensing receptor	Homo sapiens	18-22
32422543-12	2020	BRAF mutation analysis was primarily performed using the Cobas 4800 BRAF V600 Mutation Test (92.8%) on formalin-fixed, paraffin-embedded tissue (95.8%).	Paraffin	119-127	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
32150626-4	2020	EGFR expression was assessed on the archival Formalin Fixed Paraffin Embedded (FFPE) blocks using immunohistochemical staining technique.	Paraffin	60-68	epidermal growth factor receptor	Homo sapiens	0-4
32365531-3	2020	The levels of AR mRNA and protein in frozen, formalin-fixed, paraffin-embedded tissue samples from PTC and adjacent normal thyroid tissue were assessed by quantitative real-time polymerase chain reaction and immunohistochemical staining, respectively, and the relationships between AR expression and clinical features were analyzed.	Paraffin	61-69	androgen receptor	Homo sapiens	14-16
31205070-3	2020	We investigated 6 antibodies that are commonly used for breast cancer subtyping in research studies with immunohistochemistry (ER, PR, HER2, CK5/6, EGFR, and Ki67) in formalin-fixed paraffin-embedded breast tissue microarrays consisting of 148 patients.	Paraffin	182-190	erb-b2 receptor tyrosine kinase 2	Homo sapiens	135-139
31649039-0	2020	Justification of direct Sanger sequencing application for detection of KIT and PDGFRalpha gene mutations in formalin-fixed, paraffin-embedded samples from gastrointestinal stromal tumours.	Paraffin	124-132	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	71-74
32509056-7	2020	The expression of INHBA in paraffin-embedded NPC tissues was detected by immunohistochemistry (IHC).	Paraffin	27-35	inhibin subunit beta A	Homo sapiens	18-23
32509056-10	2020	In paraffin-embedded NPC tissues, immunoreactivity of INHBA was primarily detected in 53.70% (58/108) of these patients.	Paraffin	3-11	inhibin subunit beta A	Homo sapiens	54-59
32245434-0	2020	Clinical performance evaluation of the Idylla  EGFR Mutation Test on formalin-fixed paraffin-embedded tissue of non-small cell lung cancer.	Paraffin	84-92	epidermal growth factor receptor	Homo sapiens	47-51
32245434-3	2020	The Idylla  EGFR Mutation Test is a simple, fast and reliable method designed for the detection of EGFR mutations from formalin-fixed paraffin-embedded samples.	Paraffin	134-142	epidermal growth factor receptor	Homo sapiens	12-16
32245434-3	2020	The Idylla  EGFR Mutation Test is a simple, fast and reliable method designed for the detection of EGFR mutations from formalin-fixed paraffin-embedded samples.	Paraffin	134-142	epidermal growth factor receptor	Homo sapiens	99-103
32245434-5	2020	METHODS: EGFR mutational status was determined on 132 archived formalin-fixed paraffin-embedded tissue sections with Idylla  technology.	Paraffin	78-86	epidermal growth factor receptor	Homo sapiens	9-13
32184668-5	2020	Methods: We assessed the expression of LETM1 and genes related to cancer stemness, epithelial-mesenchymal transition (EMT), cell cycle, and PI3K/Akt signaling in 133 paraffin-embedded PCa tissue samples and cancer cells by using immunohistochemistry, immunofluorescence, and Western blotting.	Paraffin	166-174	AKT serine/threonine kinase 1	Homo sapiens	145-148
31846974-4	2020	The expression of c-Met was determined by immunohistochemistry using archived formalin-fixed paraffin-embedded samples.	Paraffin	93-101	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	18-23
31891442-4	2020	Trop-2 expression was assessed in 143 formalin-fixed-paraffin-embedded tumors and seven primary tumor cell lines by immunohistochemistry and flow cytometry, respectively.	Paraffin	53-61	tumor associated calcium signal transducer 2	Homo sapiens	0-6
32117765-4	2020	Methods: Trop-2 expression was assessed in 90 formalin-fixed-paraffin-embedded tumors and nine primary tumor cell lines by immunohistochemistry (IHC) and flow cytometry, respectively.	Paraffin	61-69	tumor associated calcium signal transducer 2	Homo sapiens	9-15
32166668-2	2020	Paraffin-embedded sections of NSCLC tissues from 399 NSCLC patients diagnosed in Renmin Hospital of Wuhan University were collected, 103 of them were detected for exons 18-21 mutation of EGFR by Sanger sequencing method, 296 cases were detected for exons 18-21 mutation by ARMS-PCR method.	Paraffin	0-8	epidermal growth factor receptor	Homo sapiens	187-191
32106280-4	2020	In the present study, we have investigated TOX expression in normal and neoplastic lymphoid tissues using a novel rat monoclonal antibody that recognizes its target molecule in paraffin-embedded tissue sections.	Paraffin	177-185	thymocyte selection-associated high mobility group box	Rattus norvegicus	43-46
32074729-3	2020	Paraffin sections of tissues were immune stained for p-AKT and p-mTOR, and the expression was assessed and correlated with the clinical features and prognosis.	Paraffin	0-8	mechanistic target of rapamycin kinase	Homo sapiens	65-69
32110671-5	2020	Next-generation sequencing on formalin fixed paraffin-embedded (FFPE) tissue was also performed and suggested HER2 gene amplification in the FFPE tissue.	Paraffin	45-53	erb-b2 receptor tyrosine kinase 2	Homo sapiens	110-114
32025485-2	2020	For NSCLC patients, EGFR mutation testing is performed using the commercial Cobas EGFR Mutation test v2.0, which can be used to analyze both formalin-fixed, paraffin-embedded (FFPE) tissue (FFPE test, or FT) and plasma samples (plasma test, or PT).	Paraffin	157-165	epidermal growth factor receptor	Homo sapiens	20-24
31309518-1	2020	The application of immunohistological methods provides an invaluable contribution in revealing the protein colocalization, which may reflect the occurrence of molecular interaction processes.This chapter describes comprehensive protocols for detection of S100A7/JAB1 colocalization by immunohistochemistry in archival formalin-fixed and paraffin-embedded skin biopsies from healthy and psoriatic subjects.	Paraffin	337-345	S100 calcium binding protein A7	Homo sapiens	255-261
31859115-0	2020	Comparison detection methods for EGFR in formalin-fixed paraffin-embedded tissues of patients with NSCLC.	Paraffin	56-64	epidermal growth factor receptor	Homo sapiens	33-37
31411003-2	2019	METHODS: Immunohistochemistry (IHC) techniques were used to examine the protein expression of HIF-1alpha in paraffin-embedded myeloid tissues from 82 patients with MDS and 33 controls (patients with lymphoma that is not invading myeloid tissues).	Paraffin	108-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	94-104
31545923-3	2019	This study was designed to identify an objective morphometric method for paraffin-embedded tissue samples to quantify the interganglionic distance between neighboring myenteric ganglia immunoreactive for neuron-specific enolase, as well as the number of myenteric and submucosal neuronal cell bodies/ganglion in jejunal specimens of patients with severe GI dysmotility.	Paraffin	73-81	enolase 2	Homo sapiens	204-227
31098781-0	2019	ASO Author Reflections: Precise p53 Analysis in Formalin-Fixed Paraffin-Embedded Specimens Can Predict Head and Neck Squamous Cell Carcinoma Outcomes.	Paraffin	63-71	tumor protein p53	Homo sapiens	32-35
31870098-0	2019	Cell Free Tumoral DNA Versus Paraffin Block Epidermal Growth Factor Receptor Mutation Detection in Patients with Non-Small Cell Lung Cancer.	Paraffin	29-37	epidermal growth factor receptor	Homo sapiens	44-76
31754264-2	2019	METHODS: We analysed by immunohistochemistry L1CAM protein expression in formalin-fixed, paraffin-embedded specimens from 309 GC patients.	Paraffin	89-97	L1 cell adhesion molecule	Homo sapiens	45-50
31395960-1	2019	Authors have only now noticed that in the Figure 3a, the immunohistochemical analysis of IL-4Ralpha on paraffin-embedded sections from breast is incorrect: IL-4 from breast was duplicated and used for the IL-4Ralpha staining.	Paraffin	103-111	interleukin 4	Homo sapiens	89-93
31263216-7	2019	Sequencing of PISD from paraffin-embedded tissue from the 1986 case revealed the identical homozygous variant.	Paraffin	24-32	phosphatidylserine decarboxylase	Homo sapiens	14-18
31638234-0	2019	Development of recurrence risk score using 95-gene classifier and its application to formalin-fixed paraffin-embedded tissues in ER-positive, HER2-negative and node-negative breast cancer.	Paraffin	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	142-146
31445213-0	2019	Multi-Center Evaluation of the Fully Automated PCR-Based Idylla EGFR Mutation Assay on Formalin-Fixed, Paraffin-Embedded Tissue of Human Lung Cancer.	Paraffin	103-111	epidermal growth factor receptor	Homo sapiens	64-68
31653220-5	2019	To understand the contribution of NF-kappaB in FISS, detection of activated NF-kappaB in paraffin-embedded specimens, in vitro establishment of primary cells derived from FISS, and evaluation of the effects of the NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on primary tumor cells were conducted.	Paraffin	89-97	nuclear factor kappa B subunit 1	Homo sapiens	76-85
31653220-5	2019	To understand the contribution of NF-kappaB in FISS, detection of activated NF-kappaB in paraffin-embedded specimens, in vitro establishment of primary cells derived from FISS, and evaluation of the effects of the NF-kappaB inhibitor, dehydroxymethylepoxyquinomicin (DHMEQ), on primary tumor cells were conducted.	Paraffin	89-97	nuclear factor kappa B subunit 1	Homo sapiens	76-85
31593979-6	2019	Expression of alpha-SMA protein in CAFs of the tumor microenvironment of the 44 formalin-fixed paraffin-embedded tissue blocks from the primary tumor of OPSCC evaluated by immunohistochemistry between HPV-positive and HPV-negative tumors separated by nested polymerase chain reaction.	Paraffin	95-103	actin alpha 1, skeletal muscle	Homo sapiens	14-23
31539530-3	2019	Immunohistochemical analysis of 167 paraffin-embedded archived breast cancer tissues showed that ARF3 expression was localized primarily in the cytoplasm and was significantly up-regulated in malignant specimens compared to benign specimens.	Paraffin	36-44	ADP ribosylation factor 3	Homo sapiens	97-101
31110050-2	2019	AIM: The rapid and fully automated Idylla EGFR Mutation Assay has been specifically designed to process formalin-fixed, paraffin-embedded sections without requiring preliminary DNA extraction.	Paraffin	120-128	epidermal growth factor receptor	Homo sapiens	42-46
31407509-0	2019	EGFR T790M detection in formalin-fixed paraffin-embedded tissues of patients with lung cancer using RNA-based in situ hybridization: A preliminary feasibility study.	Paraffin	39-47	epidermal growth factor receptor	Homo sapiens	0-4
31538424-4	2019	We performed immuo-histochemistry for glioma-associated oncogene homolog zinc finger protein 1 (Gli1), patched, Shh, and Ptch-mediated repression of smoothened (Smo) proteins using formalin-fixed, paraffin-embedded tissue derived from primary tumors.	Paraffin	197-205	patched 1	Homo sapiens	121-125
31493794-3	2019	However, identification of PAX3/7-FOXO1 fusion status is challenging when using formalin-fixed, paraffin-embedded (FFPE) material.	Paraffin	96-104	paired box 3	Homo sapiens	27-33
31441649-7	2019	Long-chain C18 chlorinated paraffins are also present, although they represent a relatively minor component.	Paraffin	27-36	Bardet-Biedl syndrome 9	Homo sapiens	11-14
30997532-4	2019	BRAF V600E mutation was detected using the real-time PCR in the formalin-fixed paraffin-embedded samples.	Paraffin	79-87	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
31391519-1	2019	PEBAX-5513/AgBF4/Al(NO3)3 membranes were fabricated for mixed olefin/paraffin separation.	Paraffin	69-77	NBL1, DAN family BMP antagonist	Homo sapiens	20-23
31455202-0	2019	Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue.	Paraffin	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-21
31455202-0	2019	Visualisation of HER2 homodimers in single cells from HER2 overexpressing primary formalin fixed paraffin embedded tumour tissue.	Paraffin	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-58
31262886-3	2019	PATIENTS AND METHODS: The online genomics analysis and visualization platform, R2, developed by the Oncogenomics department at the AMC (Amsterdam, The Netherlands) was used for in silico UCK2-mRNA correlation with overall survival of pancreatic cancer patients, while UCK2 protein expression was evaluated by immunohistochemistry on pancreatic tumor formalin-fixed-paraffin-embedded sections from independent pancreatic cancer patients.	Paraffin	365-373	uridine-cytidine kinase 2	Homo sapiens	187-191
31096078-7	2019	The nuclear translocation of NF-kappaB p65 was evaluated using immunofluorescence staining in paraffin-embedded slices.	Paraffin	94-102	synaptotagmin 1	Rattus norvegicus	39-42
31413756-3	2019	Methods: We retrospectively analyzed the expression of PSMD1 in 241 paraffin-embedded GC specimens of the training cohort by immunohistochemistry.	Paraffin	68-76	proteasome 26S subunit, non-ATPase 1	Homo sapiens	55-60
31367630-9	2019	DNA sequencing performed on paraffin-embedded tissue revealed two exactly coincident alterations in CDH1, C.57T&gt;G and C.1418A&gt;T. CONCLUSION: This case suggests that the combination of CDH1 mutations and WNT/beta-catenin signaling activation contributes to the carcinogenesis of gastrointestinal SMPC.	Paraffin	28-36	cadherin 1	Homo sapiens	100-104
31367630-9	2019	DNA sequencing performed on paraffin-embedded tissue revealed two exactly coincident alterations in CDH1, C.57T&gt;G and C.1418A&gt;T. CONCLUSION: This case suggests that the combination of CDH1 mutations and WNT/beta-catenin signaling activation contributes to the carcinogenesis of gastrointestinal SMPC.	Paraffin	28-36	cadherin 1	Homo sapiens	190-194
31208050-5	2019	Moreover, this method was proven to distinguish the BRAF V600E mutant from the wild type based on intrinsic differences by using a total of 312 CRC tissue samples paraffin-embedded, deparaffinized, and stained.	Paraffin	163-171	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	52-56
31234146-6	2019	In parallel, the expression of CRP and growth signaling pathway proteins was assessed on cell lines and paraffin-embedded primary pNEN.	Paraffin	104-112	C-reactive protein	Homo sapiens	31-34
29862474-2	2019	AR expression in 40 paraffin-embedded specimens of primarily diagnosed NMIBC after transurethral resection was examined by immunohistochemistry using a monoclonal AR antibody.	Paraffin	20-28	androgen receptor	Homo sapiens	0-2
30426328-0	2019	Comparison of Three Real-Time PCR Assays for the Detection of PIK3CA Somatic Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Breast Carcinomas.	Paraffin	105-113	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	62-68
31258360-6	2019	The EGFR protein levels were detected with immunohistochemistry methods from the sections of the patients" paraffin blocks.	Paraffin	107-115	epidermal growth factor receptor	Homo sapiens	4-8
31197538-7	2019	It was then extended to image and quantitatively evaluate HER2 homodimers in clinical formalin-fixed paraffin-embedded breast cancer tissue specimens.	Paraffin	101-109	erb-b2 receptor tyrosine kinase 2	Homo sapiens	58-62
28968266-4	2019	ERG IHC was performed on sections off the surface of corresponding paraffin tissue blocks.	Paraffin	67-75	ETS transcription factor ERG	Homo sapiens	0-3
31018021-5	2019	METHODS: CD4+ T-cell infiltration in Doc-treated paraffin-embedded specimens from transurethral resection of prostate, radical prostatectomy, or bone metastasis was detected by immunohistochemistry.	Paraffin	49-57	CD4 molecule	Homo sapiens	9-12
31127887-0	2019	Detection of Epidermal Growth Factor Receptor (EGFR) Gene Mutation in Formalin Fixed Paraffin Embedded Tissue by Polymerase Chain Reaction-Single Strand Conformational Polymorphism (PCR-SSCP) in Non-Small Cell Lung Cancer in the Northeastern Region of Thailand Background: The use of targeted specific genes in therapeutic and treatment decisions has been considered forlung cancer.	Paraffin	85-93	epidermal growth factor receptor	Homo sapiens	13-45
31127887-0	2019	Detection of Epidermal Growth Factor Receptor (EGFR) Gene Mutation in Formalin Fixed Paraffin Embedded Tissue by Polymerase Chain Reaction-Single Strand Conformational Polymorphism (PCR-SSCP) in Non-Small Cell Lung Cancer in the Northeastern Region of Thailand Background: The use of targeted specific genes in therapeutic and treatment decisions has been considered forlung cancer.	Paraffin	85-93	epidermal growth factor receptor	Homo sapiens	47-51
31139323-9	2019	We evaluated TOX protein expression in paraffin-embedded skin biopsies with immunohistochemistry, showing nuclear staining of CTCL infiltrates, suggesting it is a candidate diagnostic biomarker.	Paraffin	39-47	TSPY like 2	Homo sapiens	126-130
31218105-4	2019	HVEM expression was assessed in fresh and 140 archived paraffin-embedded ccRCC tissue samples by quantitative RT-PCR, western blot, and immunohistochemical staining.	Paraffin	55-63	TNF receptor superfamily member 14	Homo sapiens	0-4
31113916-3	2019	Immunohistochemical (IHC) analysis was used to detect ZNF207 protein expression in 135 cases of randomly selected paraffin-embedded HCC tissues.	Paraffin	114-122	zinc finger protein 207	Homo sapiens	54-60
30746817-4	2019	The expression of HIF-1alpha and MAP1LC3B was analyzed in the paraffin-embedded specimens by immunohistochemical method and in the hypoxic SACC-LM cells by immunofluorescence.	Paraffin	62-70	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
30944626-4	2019	The expression of GRHL1 was detected by immunohistochemistry in 266 formalin-fixed paraffin-embedded ESCC samples with the help of Pearson"s chi2 test, and Cox regression analysis was employed in order to distinguish independent prognostic factors.	Paraffin	83-91	grainyhead like transcription factor 1	Homo sapiens	18-23
30952761-4	2019	PIK3CA mutations were identified in formalin-fixed and paraffin-embedded surgical specimens from 112 patients with EBV-GC with available tumor tissue samples.	Paraffin	55-63	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-6
31040705-6	2019	Immunohistochemical analysis showed that 69.2% paraffin-embedded archival ESCC specimens exhibited high levels of PRR11 expression, and multivariate analysis revealed that PRR11 upregulation might be an independent prognostic indicator for the survival of patients with ESCC.	Paraffin	47-55	proline rich 11	Homo sapiens	114-119
31040705-6	2019	Immunohistochemical analysis showed that 69.2% paraffin-embedded archival ESCC specimens exhibited high levels of PRR11 expression, and multivariate analysis revealed that PRR11 upregulation might be an independent prognostic indicator for the survival of patients with ESCC.	Paraffin	47-55	proline rich 11	Homo sapiens	172-177
31183395-7	2019	Quantitative real-time PCR demonstrated that higher expression levels of IFN-gamma but muted IL-2 and KLRG-1 expression was detected in the cervix of patients with HPV16+ compared to HPV18+, which were further confirmed using 20 paraffin sections of cervical conization tissue.	Paraffin	229-237	interferon gamma	Homo sapiens	73-82
30882204-6	2019	We used the ImCal method to quantify HER2 in 35 breast cancer formalin-fixed paraffin-embedded patient samples, revealing a high degree of heterogeneity among patients, which contrasts with the homogeneous immunohistochemistry patient classification.	Paraffin	77-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-41
30971541-5	2019	TROP-2 expression was investigated via immunohistochemistry in sections prepared from paraffin blocks of the cases.	Paraffin	86-94	tumor associated calcium signal transducer 2	Homo sapiens	0-6
32308283-3	2019	Materials and Methods: Immunoexpression of E-cadherin antibody was evaluated in previously diagnosed, paraffin-embedded sections of 20 tissues each of well-differentiated and moderately differentiated OSCC, 17 tissues of poorly differentiated OSCC, and 10 tissues of normal oral mucosa; Chi-square test, analysis of variance, and Tukey"s honestly significant difference test were employed for statistical analysis.	Paraffin	102-110	cadherin 1	Homo sapiens	43-53
30768923-2	2019	METHODS: Immunohistochemistry was used to detect EDNRB protein expression level in 67 HCC paraffin embedded tissues and adjacent tissues.	Paraffin	90-98	endothelin receptor type B	Homo sapiens	49-54
29862475-4	2019	Twenty-four paraffin-embedded cases (14 females 10 men, 21-79 years) from different localizations were found to express somatostatin-receptor type 2 (SSTR2).	Paraffin	12-20	somatostatin receptor 2	Homo sapiens	120-148
31025635-4	2019	Immunohistochemical staining for IGFBP-rP1 was performed on paraffin-embedded tissues and the results were correlated with the patient"s demographic and clinicopathological data.	Paraffin	60-68	insulin like growth factor binding protein 7	Homo sapiens	33-42
29862475-4	2019	Twenty-four paraffin-embedded cases (14 females 10 men, 21-79 years) from different localizations were found to express somatostatin-receptor type 2 (SSTR2).	Paraffin	12-20	somatostatin receptor 2	Homo sapiens	150-155
31198984-6	2019	Immunohistochemistry (IHC) was used to determine the presence of WNT5A protein in the sections of formalin-fixed, paraffin-embedded tissue specimens derived from unchanged endome-trial controls (n = 6) and EC tumors (n = 19).	Paraffin	114-122	Wnt family member 5A	Homo sapiens	65-78
30866511-3	2019	We provide descriptions of electron microscopy and confocal microscopy of kuru amyloid plaques retrieved from a paraffin-embedded block of an old kuru case, named Kupenota.	Paraffin	112-120	prion protein	Homo sapiens	74-78
30628714-4	2019	The expression levels of gap-associated proteins of the Wnt/PCP pathway in paraffin-embedded cervical carcinoma samples were also evaluated by immunohistochemical staining.	Paraffin	75-83	Wnt family member 5A	Homo sapiens	56-59
30110125-2	2019	In a mass spectrometry-based global proteomic study of 44 formalin-fixed, paraffin-embedded (FFPE) primary TNBC tumors and 10 corresponding metastases, we found that Cytochrome P450 reductase (CYPOR) expression correlated with patient outcome.	Paraffin	74-82	cytochrome p450 oxidoreductase	Homo sapiens	193-198
30484953-3	2019	In this study, we examined the expression of Dab1 in 38 breast cancer paraffin sections, as well as 60 paired frozen breast cancer and their adjacent tissues.	Paraffin	70-78	DAB adaptor protein 1	Homo sapiens	45-49
30838039-6	2019	Results: The concordance rate of HER2 amplification examined in plasma and formalin-fixed paraffin-embedded (FFPE) samples with ddPCR was 81.4%, with a sensitivity of 76.5% and a specificity of 83.8%.	Paraffin	90-98	erb-b2 receptor tyrosine kinase 2	Homo sapiens	33-37
30783512-5	2019	The TGFbeta-EMT signature was validated as prognostic of 5-year MFS in 3 cohorts: a 133 NSCLC tumor dataset (P = 0.0002), a NanoString assays of RNA isolated from formalin-fixed paraffin-embedded samples from these same tumors (P = 0.0015), and a previously published NSCLC MFS dataset (P = 0.0015).	Paraffin	178-186	transforming growth factor beta 1	Homo sapiens	4-11
30811471-0	2019	Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma.	Paraffin	161-169	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	128-132
30439350-6	2019	Here, using antibodies against TKS5 and Cortactin, we describe for the first time structures strongly resembling invadopodia in various paraffin-embedded human tumor surgical specimens from pancreas and other organs.	Paraffin	136-144	SH3 and PX domains 2A	Homo sapiens	31-35
30657411-0	2019	Development and Characterization of a Novel Monoclonal Antibody Against Chitinase-like Protein CHID1 Applicable for Immunohistochemistry on Formalin Fixed Paraffin-Embedded Sections.	Paraffin	155-163	chitinase domain containing 1	Homo sapiens	95-100
30657411-5	2019	3D4 mAb specifically binds human CHID1 and was successfully used in enzyme-linked immunosorbent assay, immunoblotting, immunofluorescence on paraformaldehyde-fixed cells, and in immunohistochemistry of paraffin-embedded tissue specimens.	Paraffin	202-210	chitinase domain containing 1	Homo sapiens	33-38
30704487-3	2019	METHODS: The expression of AP-1 was examined by immunohistochemistry on paraffin-embedded tissues obtained from PTC and correspondent paracancerous tissues of 82 patients.	Paraffin	72-80	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	27-31
30583668-3	2018	Materials and methods: Tetra-ARMS PCR was employed to analyze the polymorphism status of theASIC1 and IL-6 genes with 85 paraffin-embedded tissue blocks from cases and 117 normal blood samples as controls.We also investigated mRNA expression levels of these genes in 12 cases and controls using real-time PCR.	Paraffin	121-129	interleukin 6	Homo sapiens	102-106
30542695-6	2019	The relationship between BPTF with clinicopathological features and the prognosis of glioma patients was analyzed by immunohistochemical staining in 113 cases of paraffin-embedded primary glioma specimens.	Paraffin	162-170	bromodomain PHD finger transcription factor	Homo sapiens	25-29
32099599-6	2019	Methods: Quantitative real-time polymerase chain reactions were carried out to analyze the expression levels of Snail1 in both normal and tumor specimens from a total of 122 paraffin-embedded tissues (FFPE) of CRC sample with known EMAST status.	Paraffin	174-182	snail family transcriptional repressor 1	Homo sapiens	112-118
30662627-0	2018	Droplet digital PCR for detection of BRAF V600E mutation in formalin-fixed, paraffin-embedded melanoma tissues: a comparison with Cobas  4800, Sanger sequencing, and allele-specific PCR.	Paraffin	76-84	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	37-41
30563489-0	2018	A novel detection methodology for HER2 protein quantitation in formalin-fixed, paraffin embedded clinical samples using fluorescent nanoparticles: an analytical and clinical validation study.	Paraffin	79-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-38
30674365-4	2018	METHODS: Immunohistochemistry for cyclooxygenase-2 was performed on a total of 100 oral squamous cell carcinoma formalin-fixed, paraffin-embedded blocks.	Paraffin	128-136	prostaglandin-endoperoxide synthase 2	Homo sapiens	34-50
30244634-4	2018	METHODS: Expression of miR-146b-5p and miR-146b-3p was assessed in formalin-fixed paraffin-embedded (FFPE) tissues samples of PTC patients and the relationship with lymph node metastasis was analyzed.. A variety of PTC cells including BHP10-3 and K1 cells were cultured and miR-146b-5p or miR-146b-3p were over-expressed with microRNA mimics.	Paraffin	82-90	microRNA 146b	Homo sapiens	23-31
29406329-5	2018	BRAF V600E status was assessed by pyrosequencing of DNA extracted from excess formalin-fixed, paraffin-embedded surgical material.	Paraffin	94-102	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
30459817-6	2018	A semi-quantitative scoring system was applied for demonstrating FOXJ1 localization in five areas per paraffin section, with individual sections being scored between 0 and 2.	Paraffin	102-110	forkhead box J1	Homo sapiens	65-70
30400781-4	2018	METHODS: The methylation status of 13 CpG sites (chr7: 23287345-23,287,426) in GPNMB gene"s promoter, was analyzed by pyrosequencing in human CRC cell lines (HCT116, SW480, and HT29) and microdissected African American paraffin embedded samples (20 normal, 21 non-advanced adenoma (NA), 48 advanced adenoma (AD), and 20 cancer tissues.	Paraffin	219-227	glycoprotein nmb	Homo sapiens	79-84
29802359-0	2018	Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas.	Paraffin	87-95	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	29-33
30299371-0	2018	Detection of IDH1 and IDH2 Mutation in Formalin-fixed Paraffin-embedded Gliomas Using Allele-specific COLD-PCR and Probe Melting Curve Analysis.	Paraffin	54-62	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	22-26
29981867-5	2018	We evaluated the diagnostic value of different methods to detect IDH2 mutations in formalin-fixed, paraffin-embedded tumor samples.	Paraffin	99-107	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	65-69
30243897-4	2018	It is based on EGFR screening methods using paraffin-embedded tumour specimen to select patients eligible for treatment.	Paraffin	44-52	epidermal growth factor receptor	Homo sapiens	15-19
29948147-4	2018	Whole-exome and RNA sequencing were performed on three formalin-fixed, paraffin-embedded ERG-positive and negative prostate cancer samples.	Paraffin	71-79	ETS transcription factor ERG	Homo sapiens	89-92
30541168-2	2018	Previously, the mutation of the BRAF gene V595E was identified in approximately 85 % of canine TCC cases by DNA sequencing of TCC tumour cells, both in frozen and paraffin-embedded tissue sections, as well as in urine.	Paraffin	163-171	B-Raf proto-oncogene, serine/threonine kinase	Canis lupus familiaris	32-36
29866615-3	2018	HER2 immunohistochemistry was performed using formalin-fixed, paraffin-embedded primary tumor specimens.	Paraffin	62-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
30211098-7	2018	Expression of mutant p53 protein from NPC tissue paraffin block with immunohistochemical cracking technique was using monoclonal rabbit Anti Human p53 clone 318-6-11 (Dako, North America, Inc., 6392 Via Real Carpinteria, CA 93013 USA), microscope light binoculars was assessed visually by an Anatomical Pathology Consultant.	Paraffin	49-57	tumor protein p53	Homo sapiens	21-24
30233874-8	2018	Methods: Mutations in EGFR gene were examined using real-time PCR technique in 1,108 formalin-fixed paraffin-embedded (FFPE) tissues, 398 FFPE cell-blocks and 470 cytological specimens of NSCLC.	Paraffin	100-108	epidermal growth factor receptor	Homo sapiens	22-26
30115035-0	2018	PIK3CA mutation is a favorable prognostic factor in esophageal cancer: molecular profile by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue.	Paraffin	161-169	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-6
30115035-15	2018	CONCLUSIONS: Our study provided profiles of cancer-related genes in Japanese patients with esophageal cancer by next-generation sequencing using surgically resected formalin-fixed, paraffin-embedded tissue, and identified the PIK3CA mutation as a favorable prognosis biomarker.	Paraffin	181-189	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	226-232
30009773-1	2018	AIMS: To investigate whether immunohistochemistry (IHC) could be used to screen BRAF mutation status in formalin-fixed paraffin-embedded (FFPE) colorectal carcinoma (CRC) and papillary thyroid carcinoma (PTC) samples.	Paraffin	119-127	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	80-84
33626829-0	2018	Real-Time PCR to Detect alpha-1 Antitrypsin S and Z Alleles in Formalin-Fixed Paraffin-Embedded Tissue.	Paraffin	78-86	serpin family A member 1	Homo sapiens	24-43
30087576-2	2018	The present study was designed to evaluate a chip-based digital PCR (dPCR) system for assessing HER2 amplification from formalin-fixed paraffin-embedded breast carcinoma tissue and to compare this system with immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH).	Paraffin	135-143	erb-b2 receptor tyrosine kinase 2	Homo sapiens	96-100
30087576-6	2018	Conclusion: These results demonstrate that chip-based dPCR is suitable for HER2 amplification detection in formalin-fixed paraffin-embedded samples in a clinical setting, providing the advantages of superior turnaround time, cost-effectiveness, and increased precision with absolute quantification compared with conventional tests such as FISH and IHC.	Paraffin	122-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	75-79
30031830-2	2018	METHODS: PIK3CA copy number status was assessed with fluorescence in situ hybridization in tissue microarrays generated from archival paraffin embedded blocks of 199 patients with primary penile squamous cell carcinoma (PSCC).	Paraffin	134-142	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	9-15
29952351-7	2018	In situ hybridization was performed to examine the distribution of Linc00312 expression in paraffin-embedded histological sections that were sensitive or resistant to cisplatin.	Paraffin	91-99	long intergenic non-protein coding RNA 312	Homo sapiens	67-76
30197332-5	2018	Materials and Methods: In this cross-sectional study, immunohistochemical staining was for TWIST performed on 30 paraffin-embedded blocks of OSCC.	Paraffin	113-121	twist family bHLH transcription factor 1	Homo sapiens	91-96
29903015-5	2018	Further, expression of mammaglobin-B protein was detected in paraffin-embedded mammary tumor tissues from the same subjects by IHC.	Paraffin	61-69	secretoglobin family 2A member 1	Homo sapiens	23-36
28808873-3	2018	HuR and COX-2 protein expression was assessed immunohistochemically on paraffin-embedded breast cancer tissue sections obtained from 121 patients and was statistically analyzed with clinicopathological parameters, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2), as well as with tumor cells" proliferative capacity and overall and disease-free patients" survival.	Paraffin	71-79	prostaglandin-endoperoxide synthase 2	Homo sapiens	8-13
29767260-4	2018	The protein expression level of ASRGL1 was determined in paraffin-embedded tumor specimen by immunohistochemistry.	Paraffin	57-65	asparaginase and isoaspartyl peptidase 1	Homo sapiens	32-38
29853535-7	2018	Galectin-3 expression in formalin-fixed paraffin-embedded lung tissue sections was demonstrated by using the immunohistochemistry methods.	Paraffin	40-48	galectin 3	Rattus norvegicus	0-10
29689598-3	2018	In this study, we analyzed the presence of PIK3CA mutations in formalin-fixed, paraffin-embedded, metastatic tissue and corresponding ctDNA from serum of patients with advanced breast cancer using a highly sensitive, optimized droplet digital PCR (ddPCR) assay.	Paraffin	79-87	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	43-49
29879227-9	2018	Although these DNA samples contain low overall yield of amplifiable DNA, our newly-developed assay successfully revealed BRAF V600 mutations in 6 of 93 formalin-fixed paraffin-embedded colorectal cancer tissues which KRAS mutation was not detected.	Paraffin	167-175	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	121-125
29866191-2	2018	METHODS: The component levels of the ERK-P65-miR23a/27a/24 axis in four fresh GC tissues, 101 paraffin-embedded GC tissues and four GC cell lines were determined by Western blotting, immunohistochemistry (IHC) or qRT-PCR.	Paraffin	94-102	mitogen-activated protein kinase 1	Homo sapiens	37-40
29297092-6	2018	Expression of COX-2 was studied by immunohistochemistry of formalin-fixed paraffin-embedded tissue samples of 20 melanomas.	Paraffin	74-82	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
29783799-11	2018	The paraffin-embedded tissues of all cases showed immunoreactivity for NSE and Syn, and the positive propotion of CgA was 10/17.	Paraffin	4-12	enolase 2	Homo sapiens	71-74
29783799-11	2018	The paraffin-embedded tissues of all cases showed immunoreactivity for NSE and Syn, and the positive propotion of CgA was 10/17.	Paraffin	4-12	chromogranin A	Homo sapiens	114-117
29394168-11	2018	Molecular examination (performed on paraffin-embedded tumor tissue using a 517 gene fusion next-generation sequencing assay) showed a JAZF1/SUZ12 translocation, which was then confirmed by fluorescence in situ hybridization (FISH).	Paraffin	36-44	JAZF zinc finger 1	Homo sapiens	134-139
29602637-5	2018	Expression of importin-11 was detected in 134 formalin-fixed and paraffin-embedded (FFPE) BCa tissues and 10 paired nonneoplastic bladder tissue specimens by immunohistochemistry.	Paraffin	65-73	importin 11	Homo sapiens	14-25
29716544-4	2018	Immunohistochemistry was used to examine the expression of NLRP3 and IL-1beta in the paraffin-embedded OSCC tissues.	Paraffin	85-93	NLR family pyrin domain containing 3	Homo sapiens	59-64
29716544-4	2018	Immunohistochemistry was used to examine the expression of NLRP3 and IL-1beta in the paraffin-embedded OSCC tissues.	Paraffin	85-93	interleukin 1 beta	Homo sapiens	69-77
29716544-9	2018	Obvious expression of NLRP3 and IL-1beta was found in the paraffin-embedded OSCC tissues, and the NLRP3 expression levels were correlated with the tumor size, lymphonode metastatic status and IL-1beta expression.	Paraffin	58-66	NLR family pyrin domain containing 3	Homo sapiens	22-27
29716544-9	2018	Obvious expression of NLRP3 and IL-1beta was found in the paraffin-embedded OSCC tissues, and the NLRP3 expression levels were correlated with the tumor size, lymphonode metastatic status and IL-1beta expression.	Paraffin	58-66	interleukin 1 beta	Homo sapiens	32-40
29530782-1	2018	PURPOSE: Prior studies have shown that nuclear reactivity for BRCA1-associated protein-1 (BAP1) yields prognostic information for paraffin-embedded uveal melanomas.	Paraffin	130-138	BRCA1 associated protein 1	Homo sapiens	62-88
29530782-1	2018	PURPOSE: Prior studies have shown that nuclear reactivity for BRCA1-associated protein-1 (BAP1) yields prognostic information for paraffin-embedded uveal melanomas.	Paraffin	130-138	BRCA1 associated protein 1	Homo sapiens	90-94
29740491-4	2018	The expression of miR-137 was analyzed inhuman lung cancer A549 and H1299 cells and normal bronchial epithelial BEAS-2B cells, 10 paired formalin-fixed paraffin-embedded lung cancer and normal tissue samples, and 56 archived paraffin-embedded lung cancer tissues.	Paraffin	225-233	microRNA 137	Homo sapiens	18-25
29169286-5	2018	Reverse transcription-polymerase chain reaction analysis using a formalin-fixed, paraffin-embedded tumor tissue specimen revealed the CRTC1-MAML2 fusion gene transcript.	Paraffin	81-89	mastermind like transcriptional coactivator 2	Homo sapiens	140-145
29565447-15	2018	The expression of interstitial IL-6 in paraffin-embedded tissues was detected by immunohistochemistry.	Paraffin	39-47	interleukin 6	Homo sapiens	31-35
29674997-10	2018	We also developed a protocol allowing efficient detection of VPAC1 by immunohistochemistry in paraffin-embedded human gastrointestinal tissue sections.	Paraffin	94-102	vasoactive intestinal peptide receptor 1	Homo sapiens	61-66
29552224-5	2018	In the present study, ERRalpha expression was detected in 15 fresh CRC tissues using quantitative real-time polymerase chain reaction (RT-qPCR) and in 128 paraffin-embedded CRC tissues using immunohistochemistry.	Paraffin	155-163	estrogen related receptor alpha	Homo sapiens	22-30
29104286-7	2018	Semiquantitative immunofluorescence and confocal imaging were used to assess ASC-specific protein expression in formalin-fixed paraffin-embedded tissue sections of breast of women and mammary tissue of mice following a low-fat (LF) or high-fat (HF) diet for 17 weeks.	Paraffin	127-135	PYD and CARD domain containing	Homo sapiens	77-80
29363723-8	2018	These antibodies against recombinant proteins may be used effectively to detect BDV p24 and p40 in paraffin sections.	Paraffin	99-107	transmembrane p24 trafficking protein 2	Homo sapiens	84-87
29658453-2	2018	METHODS: Real-time fluorescence quantitative PCR was used to detect BRAF-V600E mutation in paraffin-embedded tissue samples from 26 children with LCH.	Paraffin	91-99	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	68-72
29545609-3	2018	By staining thin (5-10 microm) paraffin and thick (50 microm) agarose tissue sections, we detected HER2- and CEA-positive human tumour cells infiltrating the surrounding tissues or metastasizing to different organs, including the brain, testis, lung, liver, and lymph nodes.	Paraffin	31-39	erb-b2 receptor tyrosine kinase 2	Homo sapiens	99-103
29467863-15	2018	CastPCR technology is a robust method with high sensitivity for the molecular detection of EGFR and BRAF mutations in clinical formalin-fixed paraffin-embedded samples.	Paraffin	142-150	epidermal growth factor receptor	Homo sapiens	91-95
27362474-0	2018	Immunoreactivity of a Monoclonal Antibody to SS18-SSX Fusion Gene Product in Formalin-fixed Paraffin-embedded Synovial Sarcoma Tissue Section.	Paraffin	92-100	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	45-49
29286163-9	2018	Staining of IFN-gamma in paraffin-embedded samples was positive in 92.6% (25/27) of specimens in which Aspergillus spp were the causative pathogen, which was significantly higher compared with specimens in which Mucorales was causative (P&lt;0.001), with only 4.2% (1/24) of specimens staining positive for IFN-gamma.	Paraffin	25-33	interferon gamma	Homo sapiens	12-21
29630110-5	2018	Immunohistochemical staining was used to assess the expression of UBE2C in 216 paraffin-embedded gastric cancer tissues.	Paraffin	79-87	ubiquitin conjugating enzyme E2 C	Homo sapiens	66-71
29517684-4	2018	In this paper, we investigated the expression of CXCL14 and NOS1 in specimens from patients with stage I-IIIA nonsmall cell lung cancer (NSCLC) after curative resection, and evaluated the prognostic significance of this gene expression in stromal fibroblasts and cancer cells.Immunohistochemistry was used to detect the expression of CXCL14 and NOS1 in 106 formalin fixed, paraffin-embedded specimens from patients with stage I-IIIA NSCLC.	Paraffin	373-381	C-X-C motif chemokine ligand 14	Homo sapiens	49-55
29435033-6	2018	Immunohistochemical analysis of 137 paraffin-embedded HCC tissue samples indicated that the expression of FXYD3 was associated with HCC clinicopathological characteristics.	Paraffin	36-44	FXYD domain containing ion transport regulator 3	Homo sapiens	106-111
29467863-15	2018	CastPCR technology is a robust method with high sensitivity for the molecular detection of EGFR and BRAF mutations in clinical formalin-fixed paraffin-embedded samples.	Paraffin	142-150	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	100-104
30511522-0	2018	[Paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples].	Paraffin	1-9	cyclin dependent kinase inhibitor 2A	Homo sapiens	64-67
29486735-5	2018	MK expression was assessed in post-surgical immunohistochemical studies of specimens in paraffin blocks.	Paraffin	88-96	midkine	Homo sapiens	0-2
30511522-1	2018	OBJECTIVE: To investigate paraffin section thickness in immunohistochemical detection of p16 expression in cervical tissue samples.	Paraffin	26-34	cyclin dependent kinase inhibitor 2A	Homo sapiens	89-92
30511522-3	2018	The results of p16 protein expression in paraffin sections with thickness of 2, 3, 4, 5 and 6 mum were compared using Logistic regression analysis.	Paraffin	41-49	cyclin dependent kinase inhibitor 2A	Homo sapiens	15-18
30511522-7	2018	CONCLUSIONS: Paraffin sections with thickness of 3.0-5.0 mum are recommended for immnohistochemical staining of p16 protein in cervical tissue samples.	Paraffin	13-21	cyclin dependent kinase inhibitor 2A	Homo sapiens	112-115
28219109-10	2018	In conclusion, highly sensitive molecular assays remain the gold standard for BRAF mutation analysis in LCH paraffin-embedded lesions.	Paraffin	108-116	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	78-82
29394946-3	2018	Real-time reverse transcription quantitative polymerase chain reaction was used to evaluate the expression of miR-198-5p in 23 formalin-fixed, paraffin-embedded (FFPE) LUSC tissues and corresponding non-cancerous tissues.	Paraffin	143-151	microRNA 198	Homo sapiens	110-117
29250174-5	2017	TPD54 expression was also determined by immunohistochemistry (IHC) in paraffin-embedded PCa tissues.	Paraffin	70-78	TPD52 like 2	Homo sapiens	0-5
29474159-8	2018	Results obtained from detection of ROR1 in paraffin-embedded breast adenocarcinoma tissue blocks (n = 11) also demonstrated that PAb anti-ROR1 can effectively be used in immunohistochemistry.	Paraffin	43-51	receptor tyrosine kinase like orphan receptor 1	Homo sapiens	35-39
28994508-3	2018	METHODS: In pleural and peritoneal effusions from 147 patients with diagnosed MM or with a differential diagnosis of MM and MH, the expression of BAP1 was examined by IHC on paraffin-embedded cell blocks (n = 121) and biopsies (n = 44).	Paraffin	174-182	BRCA1 associated protein 1	Homo sapiens	146-150
29635245-5	2018	We elucidated the localization of FOXJ1 by using immunofluorescence assays in paraffin sections and primary single cells.	Paraffin	78-86	forkhead box J1	Homo sapiens	34-39
29371935-4	2017	In this study, analysis of 19 frozen and 51 paraffin-embedded clinic pathological cases showed that UCH-L5 expression in glioma tissues was lower than normal brain tissues.	Paraffin	44-52	ubiquitin C-terminal hydrolase L5	Homo sapiens	100-106
28421464-6	2017	Somatic gene sequencing revealed a novel TP53 mutation in DNA extracted from paraffin-embedded tissue, a deletion of 8bp in exon 8 (c.811_818del8; GAGGTGCG/-) in homo or hemizygosis causing a subsequent frameshift and premature stop codon at position 302.	Paraffin	77-85	tumor protein p53	Homo sapiens	41-45
28929431-0	2017	Comment on: "Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma".	Paraffin	103-111	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	70-74
28929468-0	2017	Authors" Reply to Uguen: "Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma".	Paraffin	116-124	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	83-87
29206917-3	2018	Paraffin sections from N-glycosylation inhibitor tunicamycin treated ER-/PR-/HER2+ (double negative) breast tumor in athymic nude mice exhibited reduced N-glycan but increased GRP78 expression.	Paraffin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
29206917-3	2018	Paraffin sections from N-glycosylation inhibitor tunicamycin treated ER-/PR-/HER2+ (double negative) breast tumor in athymic nude mice exhibited reduced N-glycan but increased GRP78 expression.	Paraffin	0-8	heat shock protein 5	Mus musculus	176-181
28991229-8	2018	Furthermore, immunofluorescence on paraffin-embedded human tissue from 40 glioma and 40 invasive ductal breast carcinoma patient specimens revealed that cadherin-22 expression colocalized with areas of hypoxia and significantly correlated with tumor grade and progression-free survival or stage and tumor size, respectively.	Paraffin	35-43	cadherin 22	Homo sapiens	153-164
28823399-5	2018	BAP1 expression was evaluated by immunohistochemical staining of formalin-fixed, paraffin-embedded sections.	Paraffin	81-89	BRCA1 associated protein 1	Homo sapiens	0-4
29351293-3	2018	Absolute quantification of FGFR1 from formalin fixed paraffin embedded (FFPE) tissue of laryngeal SCCa was examined in this retrospective study.	Paraffin	53-61	fibroblast growth factor receptor 1	Homo sapiens	27-32
29424924-9	2018	MiR-133b expression correlated with tumor size (p = 0.015) and differentiation status (p = 0.013) in paraffin-embedded sections, but was only correlated with pTNM staging (p = 0.032) in frozen tissue samples.	Paraffin	101-109	microRNA 133b	Homo sapiens	0-8
29424924-14	2018	MiR-133b levels were downregulated in normal tissues compared to both paraffin and frozen tumor samples, and correlated with both HuR and TTP expression, which may affect the prognosis of NSCLC patients.	Paraffin	70-78	microRNA 133b	Homo sapiens	0-8
29202724-14	2017	CONCLUSION: Only the anti-EpCAM MAb to the membrane-proximal part is able to detect EpCAM on paraffin-embedded cervical cancer tissues.	Paraffin	93-101	epithelial cell adhesion molecule	Homo sapiens	26-31
29202724-14	2017	CONCLUSION: Only the anti-EpCAM MAb to the membrane-proximal part is able to detect EpCAM on paraffin-embedded cervical cancer tissues.	Paraffin	93-101	epithelial cell adhesion molecule	Homo sapiens	84-89
28948627-2	2017	METHODS: C-KIT exon 11 ITDs were detected by PCR in DNA extracted from formalin-fixed, paraffin-embedded canine MCTs sourced from three veterinary diagnostic laboratories in Adelaide and Melbourne.	Paraffin	87-95	KIT proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	9-14
29100713-3	2017	Herein, we describe a BRAF high resolution melting (HRM) assay that can differentiate low level of V600E and V600K mutations using formalin fixed, paraffin embedded (FFPE) reference standards for assay validation.	Paraffin	147-155	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	22-26
29479053-0	2017	A Computational Workflow Translates a 58-Gene Signature to a Formalin-Fixed, Paraffin-Embedded Sample-Based Companion Diagnostic for Personalized Treatment of the BRAF-Mutation-Like Subtype of Colorectal Cancers.	Paraffin	77-85	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	163-167
29479053-5	2017	The aim of this study is to translate this 58-gene signature from a research setting to a robust companion diagnostic that can use formalin-fixed, paraffin-embedded (FFPE) samples to select patients with the BRAF-mutation-like subtype.	Paraffin	147-155	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	208-212
28985579-6	2017	SIRT-3 expression was investigated by immunohistochemistry (IHC) in formalin-fixed and paraffin-embedded (FFPE) samples.	Paraffin	87-95	sirtuin 3	Homo sapiens	0-6
29103753-5	2017	MATERIALS AND METHODS: In this study, we examined BRAF V600E mutation from paraffin embedded OKC samples by tumor cell enriched microdissection and TA cloning of amplified DNA.	Paraffin	75-83	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	50-54
29042640-2	2017	Our goal was to validate multiplex immunofluorescence (mIF) panels to apply to formalin-fixed and paraffin-embedded tissues using a set of immune marker antibodies, with the Opal  7 color Kit (PerkinElmer) in the same tissue section.	Paraffin	98-106	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	55-58
29113241-4	2017	The Mena protein expression level was analyzed in paraffin-embedded GC samples and adjacent normal tissues by immunohistochemistry.	Paraffin	50-58	ENAH actin regulator	Homo sapiens	4-8
29113241-7	2017	In the paraffin-embedded tissue samples, the protein expression level of Mena was higher in G Ct issues compared with in adjacent normal tissues.	Paraffin	7-15	ENAH actin regulator	Homo sapiens	73-77
29285256-3	2017	Methods: Immunohistochemical analyses were carried out to quantify RIP140 and LCoR expression in formalin-fixed paraffin-embedded tissue sections cervical cancer samples.	Paraffin	112-120	ligand dependent nuclear receptor corepressor	Homo sapiens	78-82
29262544-3	2017	We evaluated the Idylla  EGFR Mutation Assay (Biocartis) for the detection of EGFR mutations in archived formalin-fixed paraffin-embedded (FFPE) tumor samples from a series of 55 patients with lung adenocarcinoma and compared these results with those obtained by a pyrosequencing ISO-15189 accredited laboratory method.	Paraffin	120-128	epidermal growth factor receptor	Homo sapiens	78-82
28750448-6	2017	ErbB mRNA expression levels were determined after extraction from formalin-fixed, paraffin-embedded tissue.	Paraffin	82-90	epidermal growth factor receptor	Homo sapiens	0-4
29085449-6	2017	Immunohistochemistry on 72 archived paraffin-embedded TSCC specimens suggested that high levels of PRR11 expression were significantly associated with clinical stage (P&lt;0.001), T classification (P=0.009), N classification (P=0.017) and vital status (P=0.010).	Paraffin	36-44	proline rich 11	Homo sapiens	99-104
28419571-5	2017	We isolated, cultured and expanded four primary cell lines from endometrium and identified byRT-qPCR the expression of OCT4, SOX2 but not NANOG (undifferentiated/embryonic markers), CD44 (MSCs marker) and c-KIT (stem cell marker) genes; and the encoded Oct4, Sox2 and Cd44 proteins by Western blot or immunostaining of paraffin-embedded tissue in endometrium.	Paraffin	319-327	POU domain, class 5, transcription factor 1	Bos taurus	119-123
28954486-5	2017	Immunoexpression of E-cadherin was evaluated histologically on paraffin fixed specimens.	Paraffin	63-71	cadherin 1	Homo sapiens	20-30
28720682-0	2017	Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase.	Paraffin	69-77	epidermal growth factor receptor	Homo sapiens	21-25
28720682-0	2017	Reducing Artifactual EGFR T790M Mutations in DNA from Formalin-Fixed Paraffin-Embedded Tissue by Use of Thymine-DNA Glycosylase.	Paraffin	69-77	thymine DNA glycosylase	Homo sapiens	104-127
28756979-3	2017	METHODS: Tbeta4 antibody was applied to the 4mum-thick paraffin sections of 57 gastric GISTs by immunohistochemistry.	Paraffin	55-63	thymosin beta 4 X-linked	Homo sapiens	9-15
28589341-8	2017	However, droplet digital polymerase chain reaction is a promising and reliable assay that can be used as a diagnostic tool to genotype formalin-fixed paraffin-embedded cancer samples for EGFR or another clinically relevant somatic mutation.	Paraffin	150-158	epidermal growth factor receptor	Homo sapiens	187-191
28583847-2	2017	Quantitative real-time PCR, western blotting and immunohistochemistry revealed TIMELESS was upregulated in NPC cell lines (n = 8 vs. NP69 cells), and freshly-frozen (n = 6) and paraffin-embedded human NPC specimens (n = 108 vs. normal samples/non-tumor cells).	Paraffin	177-185	timeless circadian regulator	Homo sapiens	79-87
28349199-4	2017	In the 33/35 hGH-iCJD cases with sufficient paraffin-embedded tissue for full pathological examination, we report the accumulation of the amyloid beta (Abeta) protein associated with Alzheimer"s disease (AD) in the brains and cerebral blood vessels in 18/33 hGH-iCJD patients and for the first time in 5/12 hGH recipients who died from causes other than CJD.	Paraffin	44-52	amyloid beta precursor protein	Homo sapiens	152-157
28295636-7	2017	Later paraffin section examination and immunohistochemistry corroborated with the squash findings and a final diagnosis of primary pituitary T cell lymphoma/leukemia in association with ACTH and TSH expressing pituitary adenoma was made.	Paraffin	6-14	proopiomelanocortin	Homo sapiens	186-190
28237182-4	2017	METHODS: c-Met expression was analyzed from 137 formalin-fixed paraffin-embedded tumor samples using a validated immunostaining protocol.	Paraffin	63-71	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-14
28625519-5	2017	All 33 EGFR-activating mutations detected in formalin-fixed paraffin-embedded (FFPE) tissue samples by the conventional method were also detected by this multiplex assay.	Paraffin	60-68	epidermal growth factor receptor	Homo sapiens	7-11
29100325-2	2017	Methods: The expression level of SLC1A5 was detected in 70 gastric cancer paraffin-embedded tissues by immunohistochemistry and also was detected in gastric cancer cell lines by qRT-PCR and western blotting analysis.	Paraffin	74-82	solute carrier family 1 (neutral amino acid transporter), member 5	Mus musculus	33-39
28649946-0	2017	Choline Transporter Immunohistochemistry: An Effective Substitute for Acetylcholinesterase Histochemistry to Diagnose Hirschsprung Disease With Formalin-fixed Paraffin-embedded Rectal Biopsies.	Paraffin	159-167	solute carrier family 5 member 7	Homo sapiens	0-19
28534992-3	2017	In the present study, the expression levels of IDH-1 and HIF-1alpha in 35 formalin-fixed paraffin-embedded sections from osteosarcoma patients were investigated by immunohistochemistry.	Paraffin	89-97	hypoxia inducible factor 1 subunit alpha	Homo sapiens	57-67
28727975-13	2017	AChE on frozen/calretinin on paraffin tissue is the best approach to avoid diagnostic errors.	Paraffin	29-37	acetylcholinesterase	Tribolium castaneum	0-4
28588314-2	2017	Here, we analyzed GNAS mutations in FD which were performed by pyrosequencing DNA isolated from formalin-fixed paraffin-embedded (FFPE) tissue.	Paraffin	111-119	GNAS complex locus	Homo sapiens	18-22
30480186-7	2017	AR immunohistochemistry was done on formalin-fixed, paraffin-embedded tissue blocks.	Paraffin	52-60	androgen receptor	Homo sapiens	0-2
28440399-3	2017	Herein, we first examined AAT expression in a panel of formalin-fixed paraffin-embedded tumor tissues from 88 lung adenocarcinoma patients undergoing curative resection, using immunohistochemical methods.	Paraffin	70-78	serpin family A member 1	Homo sapiens	26-29
29774995-2	2017	Method:Immunohistochemical staining of MCT-1 and p53 was carried out in 41 cases of laryngeal squamous cell carcinoma embedded in paraffin, and the relationship between positive expression and clinicopathological data was evaluated.	Paraffin	130-138	solute carrier family 16 member 1	Homo sapiens	39-44
29774995-2	2017	Method:Immunohistochemical staining of MCT-1 and p53 was carried out in 41 cases of laryngeal squamous cell carcinoma embedded in paraffin, and the relationship between positive expression and clinicopathological data was evaluated.	Paraffin	130-138	tumor protein p53	Homo sapiens	49-52
28881595-3	2017	Immunohistochemical staining of 203 paraffin-embedded bladder cancer tissues showed that Kindlin-2 expression correlated with advanced stage, high grade, and relapse of bladder cancer.	Paraffin	36-44	FERM domain containing kindlin 2	Homo sapiens	89-98
28468035-4	2017	Results: There were 173 cases with EGFR gene mutation in 582 cases of paraffin-embedded tissue in patients with NSCLC, and the mutation rate was 29.7%(173/582).	Paraffin	70-78	epidermal growth factor receptor	Homo sapiens	35-39
27837339-4	2017	METHODS: Digital droplet PCR (ddPCR) was performed for HER2 mRNA on 178 formalin-fixed paraffin-embedded (FFPE) breast cancer specimens.	Paraffin	87-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
28588698-4	2017	Therefore, the present study determined the levels of SULT1E1, STS and estrogen receptor alpha (ERalpha) protein in paraffin-embedded specimens from 206 patients with Federation of Gynecology and Obstetrics stage II-IV EOC treated with debulking surgery and standard platinum-based adjuvant chemotherapy.	Paraffin	116-124	estrogen receptor 1	Homo sapiens	96-103
28343305-7	2017	The presence of MECT1-MAML2 was evaluated with reverse transcription polymerase chain reaction using RNA extracted from formalin-fixed paraffin-embedded tumor tissue.	Paraffin	135-143	mastermind like transcriptional coactivator 2	Homo sapiens	22-27
28306608-4	2017	Paraffin-embedded glioma specimens were detected for the COX-2 expression using immunohistochemistry.	Paraffin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	57-62
28478955-4	2017	Here we report the immunohistochemical distribution of cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) in cat ovary and oviduct, using paraffin-embedded tissue samples and commercially available antibodies.	Paraffin	155-163	cannabinoid receptor 1	Homo sapiens	55-83
28478955-4	2017	Here we report the immunohistochemical distribution of cannabinoid receptor 1 (CB1R) and fatty acid amide hydrolase (FAAH) in cat ovary and oviduct, using paraffin-embedded tissue samples and commercially available antibodies.	Paraffin	155-163	fatty acid amide hydrolase	Homo sapiens	117-121
28130756-0	2017	Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.	Paraffin	90-98	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	57-61
27586674-3	2017	MATERIALS AND METHODS: Expression of activated Notch1 in ATC and PTC paraffin-embedded tissues was determined by immunohistochemistry.	Paraffin	69-77	notch receptor 1	Homo sapiens	47-53
29515640-4	2017	Endothelin-1 staining was performed on Paraffin Embedded blocks of preoperative needle biopsies.	Paraffin	39-47	endothelin 1	Homo sapiens	0-12
26919893-5	2017	Methods The feline androgen receptor gene was characterised and used to test clonality of feline lymphomas by PCR and polyacrylamide gel electrophoresis, using archival formalin-fixed, paraffin-embedded material.	Paraffin	185-193	androgen receptor	Homo sapiens	19-36
28471195-13	2017	CONCLUSION: During development of PLA method for detection of protein complexes between p53 family members we detected interactions of p53 and p63 with T-antigen and mut-p53 and DeltaNp63 with TAp73 tumour suppressor in tumour cell lines and p53 tetramers in paraffin sections of colorectal cancer tissue.	Paraffin	259-267	tumor protein p53	Homo sapiens	88-91
28471195-13	2017	CONCLUSION: During development of PLA method for detection of protein complexes between p53 family members we detected interactions of p53 and p63 with T-antigen and mut-p53 and DeltaNp63 with TAp73 tumour suppressor in tumour cell lines and p53 tetramers in paraffin sections of colorectal cancer tissue.	Paraffin	259-267	tumor protein p53	Homo sapiens	135-138
28471195-13	2017	CONCLUSION: During development of PLA method for detection of protein complexes between p53 family members we detected interactions of p53 and p63 with T-antigen and mut-p53 and DeltaNp63 with TAp73 tumour suppressor in tumour cell lines and p53 tetramers in paraffin sections of colorectal cancer tissue.	Paraffin	259-267	tumor protein p53	Homo sapiens	135-138
28471195-13	2017	CONCLUSION: During development of PLA method for detection of protein complexes between p53 family members we detected interactions of p53 and p63 with T-antigen and mut-p53 and DeltaNp63 with TAp73 tumour suppressor in tumour cell lines and p53 tetramers in paraffin sections of colorectal cancer tissue.	Paraffin	259-267	tumor protein p53	Homo sapiens	135-138
28130756-4	2017	METHODS: In our study, we assessed and compared BRAF mutations in 59 formalin-fixed and paraffin-embedded tumor samples of patients with metastatic melanoma with next-generation sequencing (NGS), Cobas  4800 BRAF V600 mutation test CE-IVD commercial kit, high-resolution melting PCR (HRM), multiplex real-time allele specific amplification (multiplexed RT-ASA) and immunohistochemistry (IHC).	Paraffin	88-96	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	48-52
28447972-4	2017	Sequencing artifacts associated with deamination events commonly found in formalin fixed paraffin embedded tissues can be partially remedied by the use of uracil DNA glycosylase during extraction steps.	Paraffin	89-97	uracil DNA glycosylase	Homo sapiens	155-177
29714414-2	2017	METHODS: Using immunohistochemistry, we detected the expressions of JNK and p-JNK proteins in 40 cases of paraffin wax-embedded PCa and 21 cases of BPH tissues and analyzed their relationships with advanced PCa and BPH as well as with the pathologic features of advanced PCa.	Paraffin	106-118	mitogen-activated protein kinase 8	Homo sapiens	68-71
29714414-2	2017	METHODS: Using immunohistochemistry, we detected the expressions of JNK and p-JNK proteins in 40 cases of paraffin wax-embedded PCa and 21 cases of BPH tissues and analyzed their relationships with advanced PCa and BPH as well as with the pathologic features of advanced PCa.	Paraffin	106-118	mitogen-activated protein kinase 8	Homo sapiens	78-81
28363001-6	2017	The expression of Ki-67 and caspase-3 were detected in 244 paraffin sections of NET using immunohistochemistry.	Paraffin	59-67	caspase 3	Homo sapiens	28-37
28039034-3	2017	In the current study, we explored the use of quantitative real time reverse transcription-PCR (RT-qPCR) as a potential method for the accurate relative quantification of the HER2 gene using formalin fixed paraffin embedded (FFPE) breast cancer biopsy samples.	Paraffin	205-213	erb-b2 receptor tyrosine kinase 2	Homo sapiens	174-178
28356761-6	2017	The protein expression of EphB4 and EphrinB2 was examined by immunohistochemistry using paraffin-embedded tumor tissues.	Paraffin	88-96	ephrin B2	Homo sapiens	36-44
28331615-5	2017	Expression of IRF-1 and PD-L1 in archival pre-treatment formalin-fixed, paraffin-embedded tumor samples were assessed by the AQUA method of quantitative immunofluorescence.	Paraffin	72-80	interferon regulatory factor 1	Homo sapiens	14-19
28039535-4	2017	METHODS: In this study, we used ddPCR to measure the HER2 gene copy number in clinical formalin-fixed paraffin-embedded samples of 41 primary breast cancer patients.	Paraffin	102-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
27543599-3	2017	AIMS: A novel, fully automated real-time PCR-based Idylla test is assessed to detect the BRAF mutation in formalin-fixed paraffin-embedded (FFPE) thyroid samples.	Paraffin	121-129	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	89-93
26574635-5	2017	S100A11 expression was evaluated by Western blot in 45 snap-frozen specimens (15 normal ovarian epithelia, 15 normal fallopian tube epithelia, and 15 HGSCs) and by immunohistochemistry in 211 paraffin-embedded specimens (40 normal fallopian tube epithelia, 54 normal ovarian epithelia, and 117 HGSCs).	Paraffin	192-200	S100 calcium binding protein A11	Homo sapiens	0-7
27778364-10	2017	This case shows the utility of adipophilin immunostaining to prove the lipid contents in neoplastic cells, which has the advantage of using formalin-fixed paraffin-embedded tissue and making needless frozen sections and ultrastructural studies to show these findings.	Paraffin	155-163	perilipin 2	Homo sapiens	31-42
28367232-6	2017	The expression of LINC00152 was also measured in 182 paraffin-embedded human TSCC tissues by in situ hybridization, increased expression of LINC00152 was significantly correlated with TSCC progression, such as T stage (p = 0.009), N stage (p = 0.036), TNM stage (p = 0.017), and associated with relapse (p &lt; 0.001), and invasion (p &lt; 0.001).	Paraffin	53-61	cytoskeleton regulator RNA	Homo sapiens	18-27
28218046-5	2017	Thyroid transcription factor 1 expression was assessed using indirect immunohistochemical detection in formalin-fixed paraffin-embedded tumour tissue at the time of diagnosis.	Paraffin	118-126	NK2 homeobox 1	Homo sapiens	0-30
27081897-4	2017	METHODS mRNA expression of ACTC1 expression was analyzed using quantitative real-time polymerase chain reaction (qRT-PCR) in 47 formalin-fixed, paraffin-embedded glioma tissues that were graded according to WHO criteria: Grade I (n = 4); Grade II (n = 12); Grade III (n = 6); and Grade IV (n = 25).	Paraffin	144-152	actin alpha cardiac muscle 1	Homo sapiens	27-32
27786596-7	2017	RESULTS: Our results showed that TDP-43 was overexpressed in melanoma paraffin samples compared with that in nevi tissues.	Paraffin	70-78	TAR DNA binding protein	Homo sapiens	33-39
28143425-5	2017	Tissue-specific expression of IGFBP-1 and IGF-1 was detected by immunohistochemistry in paraffin-embedded NPC tissues.	Paraffin	88-96	insulin like growth factor 1	Homo sapiens	42-47
28068934-3	2017	METHODS: We examined five hotspot mutations in the PIK3CA gene (E542K, E545K, E546K, H1047R, and H1047L) in formalin-fixed and paraffin-embedded tissue sections of paired endoscopic biopsy and surgically resected specimens from 181 patients undergoing curative resection for ESCC between 2000 and 2011 using a Luminex technology-based multiplex gene mutation detection kit.	Paraffin	127-135	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	51-57
29410959-3	2017	Methods: Immunohistological analysis was performed for the evaluation of the estrogen receptor alpha (ERalpha) in paraffin-embedded tissue specimens of 16 patients with a diagnosis of branchial cleft cyst, with three of them being pregnant.	Paraffin	114-122	estrogen receptor 1	Homo sapiens	77-100
29410959-3	2017	Methods: Immunohistological analysis was performed for the evaluation of the estrogen receptor alpha (ERalpha) in paraffin-embedded tissue specimens of 16 patients with a diagnosis of branchial cleft cyst, with three of them being pregnant.	Paraffin	114-122	estrogen receptor 1	Homo sapiens	102-109
28930757-6	2017	The protein levels of CCR7 were examined by immunohistochemistry using paraffin-embedded tumor tissues.	Paraffin	71-79	C-C motif chemokine receptor 7	Homo sapiens	22-26
29250535-7	2017	The expressions of HPV16 E6 and COX-2 in paraffin-embedded tissues of the invasive ductal breast cancer were detected by qPCR and IHC.	Paraffin	41-49	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	32-37
29953781-4	2017	MATERIALS AND METHODS: C-kit expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks of confirmed consecutive available USC uterine specimens of patients diagnosed from 2000 to 2014.	Paraffin	94-102	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	23-28
27550342-10	2016	SSEA-1 is a marker that detects malignant thyroid neoplasms in formalin-fixed paraffin-embedded thyroid tissue sections and may be a useful marker for thyroid cancer stem-like cells.	Paraffin	78-86	fucosyltransferase 4	Homo sapiens	0-6
29199726-7	2017	BRAF V600E mutation analysis was done by real time polymerase chain reaction after extracting genomic DNA from the representative archived formalin fixed paraffin embedded tumor tissue.	Paraffin	154-162	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
27544315-3	2017	METHODS: In this study, we analyzed HER2 mRNA expression in clinical formalin-fixed and paraffin-embedded (FFPE) samples using a one-tube nested reverse transcription quantitative polymerase chain reaction (RT-qPCR) assay.	Paraffin	88-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-40
27997533-5	2016	Patient-specific TP53 assays were developed for 31 unique mutations identified in formalin-fixed paraffin-embedded tumour DNA from these patients.	Paraffin	97-105	tumor protein p53	Homo sapiens	17-21
27929428-4	2016	By immunohistochemistry and fluorescence in-situ hybridization, HER2 expression was investigated in formalin-fixed paraffin-embedded surgical specimens from 90 DTC patients, 45 follicular (FTC) and 45 papillary (PTC) histotypes.	Paraffin	115-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	64-68
29118812-4	2017	Immunohistochemistry was used to analyze the expression of PDE5 in paraffin-embedded tissues obtained from 103 cases of WDTC.	Paraffin	67-75	phosphodiesterase 5A	Homo sapiens	59-63
28901323-0	2017	Human epidermal growth factor receptor 2 amplification detection by droplet digital polymerase chain reaction in formalin-fixed paraffin-embedded breast and gastric cancer samples.	Paraffin	128-136	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-40
28752453-4	2017	Here, we describe a highly sensitive method to detect the AAT antigen in formalin-fixed paraffin-embedded human or mouse tissues.	Paraffin	88-96	serpin family A member 1	Homo sapiens	58-61
28760494-4	2017	METHODS: TFF1 expression was examined on paraffin-embedded sections from 91 patients with resected PDAC using immunohistochemistry.	Paraffin	41-49	trefoil factor 1	Homo sapiens	9-13
28003030-6	2016	Immunohistochemical staining for p53 was performed on paraffin-embedded 5-mum sections using mouse anti-human tumor protein p53 monoclonal antibody (DO-7, Dako, Denmark).	Paraffin	54-62	tumor protein p53	Homo sapiens	33-36
27930669-3	2016	In this study, we developed a novel RNA-FISH assay using branched DNA probe to detect FGFR3-TACC3 fusions in formaldehyde-fixed paraffin-embedded (FFPE) human BC samples.	Paraffin	128-136	transforming acidic coiled-coil containing protein 3	Homo sapiens	92-97
27825029-4	2016	STUDY DESIGN: FGF-2 expression was investigated by immunohistochemistry from paraffin-embedded tissue in 26 patients with leiomyoma, in 24 cases with STUMP and in 21 patients with LMS.	Paraffin	77-85	fibroblast growth factor 2	Homo sapiens	14-19
27562488-9	2016	In addition to highlighting motile cilia, ARL13B immunohistochemistry also robustly highlights primary cilia in formalin-fixed paraffin-embedded sections.	Paraffin	127-135	ADP ribosylation factor like GTPase 13B	Homo sapiens	42-48
27737606-5	2016	Expert commentary: The therascreen  kit is a highly sensitive real-time polymerase chain reaction test that provides standardised testing and automated interpretation of EGFR mutation status in formalin-fixed, paraffin-embedded (FFPE) tissue samples.	Paraffin	210-218	epidermal growth factor receptor	Homo sapiens	170-174
27832134-0	2016	Comparison of the QuantiGene 2.0 Assay and Real-Time RT-PCR in the Detection of p53 Isoform mRNA Expression in Formalin-Fixed Paraffin-Embedded Tissues- A Preliminary Study.	Paraffin	126-134	tumor protein p53	Homo sapiens	80-83
27891503-4	2016	In this study, we have optimized the protocol for Sanger sequencing of TP53 using DNA extracted from archival paraffin-embedded biopsies.	Paraffin	110-118	tumor protein p53	Homo sapiens	71-75
27832134-4	2016	However, there are serious limitations when detecting p53 isoforms using this method, particularly for formalin-fixed paraffin-embedded (FFPE) tissues.	Paraffin	118-126	tumor protein p53	Homo sapiens	54-57
27639703-6	2016	We evaluated the MVD and VEGF expression of paraffin-embedded bone marrow samples from patients.	Paraffin	44-52	vascular endothelial growth factor A	Homo sapiens	25-29
28026806-3	2016	The aim of this study was to design a real-time PCR-based diagnostic kit for fast and cheap of EGFR mutations testing in paraffin blocks and plasma, and kit validation using samples from patients with NSCLC, and also comparative estimation of diagnostic features of real-time PCR with wild type blocking and digital PCR for mutation testing in blood plasma.	Paraffin	121-129	epidermal growth factor receptor	Homo sapiens	95-99
28026806-6	2016	Kit for EGFR mutations was validated using 411 samples of paraffin blocks.	Paraffin	58-66	epidermal growth factor receptor	Homo sapiens	8-12
27498060-5	2016	Immunohistochemistry on 165 paraffin-embedded sections showed that high expression of DIXDC1 was significantly correlated with tumor size (P = .002), histological differentiation (P = .001), tumor node metastasis (TNM) stage (P = .001), and the proliferation marker Ki-67 (P = .000).	Paraffin	28-36	DIX domain containing 1	Homo sapiens	86-92
27780269-7	2016	Next, we have measured the p53 expression in the paraffin embedded blocks prepared from bone marrow biopsy, using immunohistochemistry, and the expression levels correlated with VB9 and VB12 levels.	Paraffin	49-57	tumor protein p53	Homo sapiens	27-30
26296380-3	2016	BRAF exon 15 mutations were searched in formalin-fixed paraffin-embedded tissues from 86 papillary thyroid carcinoma using the three methods.	Paraffin	55-63	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-4
26574629-0	2016	GNAS Mutations in Fibrous Dysplasia: A Comparative Study of Standard Sequencing and Locked Nucleic Acid PCR Sequencing on Decalcified and Nondecalcified Formalin-fixed Paraffin-embedded Tissues.	Paraffin	168-176	GNAS complex locus	Homo sapiens	0-4
27391144-3	2016	Expression of COX-2 was detected immunohistochemically in standard sections of formalin-fixed paraffin-embedded tissue samples of 85 primary melanomas, 36 lymph node metastases, and five skin metastases including 39 cases of paired primary and metastatic lesions obtained from the same patient.	Paraffin	94-102	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
27599983-6	2016	The expressions of HSP90B1 and DDIT3 proteins were detected in all paraffin-embedded biopsy samples by immunochemistry.	Paraffin	67-75	DNA damage inducible transcript 3	Homo sapiens	31-36
27818595-3	2016	Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffin-embedded tissues using polyclonal antibodies.	Paraffin	93-101	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
27699037-3	2016	Expression analysis of TFF3 in 91 ovarian cancer patients was performed by immunohistochemistry of primary paraffin-embedded tumor samples.	Paraffin	107-115	trefoil factor 3	Homo sapiens	23-27
27456361-3	2016	First of all, the expression of BAG3 was examined in formalin-fixed, paraffin-embedded specimens by immunohistochemical staining.	Paraffin	69-77	BAG cochaperone 3	Homo sapiens	32-36
27155850-4	2016	PARP activity in fresh frozen tumor tissue was assessed by an enzymatic chemiluminescence assay and PARP protein expression in paraffin-embedded tumor tissue by IHC.	Paraffin	127-135	poly(ADP-ribose) polymerase 1	Homo sapiens	0-4
27565930-2	2016	MATERIALS AND METHODS: The peptide nucleic acid-locked nucleic acid polymerase chain reaction clamp method was used to detect mutations in exons 18, 19, 20, and 21 of the EGFR gene in DNA samples extracted from paraffin-embedded tissue sections.	Paraffin	211-219	epidermal growth factor receptor	Homo sapiens	171-175
27642616-0	2016	Data showing non-conventional HLA-B27 expression in axial joints and gut tissue from B27 transgenic rats, and in frozen and paraffin-fixed synovial SpA tissue.	Paraffin	124-132	surfactant protein A1	Rattus norvegicus	148-151
27218874-7	2016	APOE genotype was assessed in DNA extracted from paraffin-embedded cardiac muscle samples.	Paraffin	49-57	apolipoprotein E	Homo sapiens	0-4
27618787-3	2016	The purpose of this study was to accurately quantify HER2-HER3 dimerisation in formalin fixed paraffin embedded (FFPE) breast cancer tissue as a novel prognostic biomarker.FFPE tissues were obtained from patients included in the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study.	Paraffin	94-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
27158755-3	2016	In this article, we examined the RHOA G17V mutation in 18 cases of AITL by 3 different techniques of Sanger sequencing, fully automated SNP genotyping, and deep sequencing, using routine diagnostic formalin-fixed paraffin-embedded tissue.	Paraffin	213-221	ras homolog family member A	Homo sapiens	33-37
27504971-3	2016	METHODS: We examined the expression of miR-4443 in MDA-MB-231/S and MDA-MB-231 Epirubicin-resistant cell lines with 76 breast cancer formalin-fixed paraffin-embedded tissues by real-time PCR.	Paraffin	148-156	microRNA 4443	Homo sapiens	39-47
27921408-5	2016	Evaluation of apoptosis in paraffin-embedded lung tissue sections was performed using terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) assay and the cleaved caspase-3 immunohistochemistry assays.	Paraffin	27-35	caspase 3	Homo sapiens	207-216
27278367-3	2016	METHODS: Protein expression of FGFR1-4 was determined by immunohistochemistry on tissue microarrays containing 951 formalin-fixed paraffin embedded OCSCC and OPSCC tissues from the University Medical Center Utrecht and University Medical Center Groningen.	Paraffin	130-138	fibroblast growth factor receptor 1	Homo sapiens	31-36
26590370-2	2016	METHODS: The expression of Cav-1 and PI3K was analysed in 51 paraffin sections of metastatic (n = 30) and non-metastastic uveal melanomas (n = 21).	Paraffin	61-69	caveolin 1	Homo sapiens	27-32
27369359-2	2016	Paraffin tumors of all clinical subtypes from 1661 patients with operable breast cancer who were treated within 4 adjuvant trials with anthracycline-taxanes chemotherapy were informative for TP53 and PIK3CA mutation status (semiconductor sequencing genotyping) and for stromal TILs density.	Paraffin	0-8	tumor protein p53	Homo sapiens	191-195
27369359-2	2016	Paraffin tumors of all clinical subtypes from 1661 patients with operable breast cancer who were treated within 4 adjuvant trials with anthracycline-taxanes chemotherapy were informative for TP53 and PIK3CA mutation status (semiconductor sequencing genotyping) and for stromal TILs density.	Paraffin	0-8	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	200-206
27153549-2	2016	MATERIALS AND METHODS: Immunohistochemistry assay was used to detect expression of APAF-1 and COX-2 in paraffin-wax embedded tissues obtained before neo-CRT for patients with RAC.	Paraffin	103-115	apoptotic peptidase activating factor 1	Homo sapiens	83-89
26951817-5	2016	A whole-transcriptome analysis of heart biopsy specimens and formalin-fixed, paraffin-embedded samples revealed that MIAT was overexpressed in patients with CCC, compared with subjects with noninflammatory dilated cardiomyopathy and controls.	Paraffin	77-85	myocardial infarction associated transcript	Homo sapiens	117-121
27393448-2	2016	Liver toxicity was induced by administered CCL4 (single dose (1:1 in liquid paraffin) orally at 1.25 ml/kg.	Paraffin	76-84	C-C motif chemokine ligand 4	Rattus norvegicus	43-47
27153549-2	2016	MATERIALS AND METHODS: Immunohistochemistry assay was used to detect expression of APAF-1 and COX-2 in paraffin-wax embedded tissues obtained before neo-CRT for patients with RAC.	Paraffin	103-115	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	94-99
26921540-0	2016	Multicenter Evaluation of a Novel Automated Rapid Detection System of BRAF Status in Formalin-Fixed, Paraffin-Embedded Tissues.	Paraffin	101-109	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	70-74
27308263-0	2016	Quantitation of CDH1 promoter methylation in formalin-fixed paraffin-embedded tissues of breast cancer patients using differential high resolution melting analysis.	Paraffin	60-68	cadherin 1	Homo sapiens	16-20
27308263-6	2016	MATERIALS AND METHODS: Using differential high resolution melting analysis (D-HRMA), the methylation level of the CDH1 gene promoter was quantified in 98 breast cancer formalin-fixed paraffin-embedded (FFPE) tissues and also 10 fresh frozen normal breast tissues.	Paraffin	183-191	cadherin 1	Homo sapiens	114-118
27223112-3	2016	AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms.	Paraffin	160-168	interleukin 1 receptor type 1	Homo sapiens	108-113
27215400-3	2016	METHODS: EGFR mutation status was assessed for lung adenocarcinoma samples (formalin fixed- paraffin embedded samples) using qPCR, SNaPshot and NGS (Ion Torrent ) techniques.	Paraffin	92-100	epidermal growth factor receptor	Homo sapiens	9-13
27257141-0	2016	Antibody validation and scoring guidelines for ABCG2 immunohistochemical staining in formalin-fixed paraffin-embedded colon cancer tissue.	Paraffin	100-108	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	47-52
27284334-4	2016	The protein levels of HIF-3alpha were determined using immunohistochemical analysis of paraffin sections of 126 paired HCC and peritumoral tissues.	Paraffin	87-95	hypoxia inducible factor 3 subunit alpha	Homo sapiens	22-32
26921540-4	2016	In a multicenter approach, we evaluated a novel and fully automated PCR-based system (Idylla) capable of detecting BRAF V600 mutations in formalin-fixed, paraffin-embedded tissue within 90 minutes with high sensitivity.	Paraffin	154-162	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	115-119
26921540-10	2016	In conclusion, the Idylla system is a highly reliable and sensitive platform for detection of BRAF V600 mutations in formalin-fixed, paraffin-embedded material, providing an efficient alternative to conventional diagnostic methods, particularly for routine diagnostics laboratories with limited experience in molecular pathology.	Paraffin	133-141	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	94-98
27222192-2	2016	METHODS: Real-time q-PCR was used to detect the expression of NPAS2 mRNA in 40 fresh CRC tissues and paired adjacent tissues; immunohistochemistry was used to detect the expression of NPAS2 protein in 120 paraffin-embedded tumor and adjacent tissues.	Paraffin	205-213	neuronal PAS domain protein 2	Homo sapiens	184-189
27222192-5	2016	Among the paraffin-embedded CRC tissues, 19.2% were positive for NPAS2 expression, as compared to a much higher rate of 62.5% in the adjacent tissues (P&lt;0.05).	Paraffin	10-18	neuronal PAS domain protein 2	Homo sapiens	65-70
26662108-4	2016	And we investigated the AGK protein expression in paraffin-embedded specimens from 140 patients with early-stage CSCC and 30 cases of NCT by immunohistochemistry (IHC).	Paraffin	50-58	acylglycerol kinase	Homo sapiens	24-27
27461620-3	2016	This study aims to report on the prevalence of EGFR mutations in NSCLC and non-squamous lung cancer patients at diagnosis, using genomic deoxyribonucleic acid (DNA) obtained from paraffin-embedded tissue samples.	Paraffin	179-187	epidermal growth factor receptor	Homo sapiens	47-51
26662803-0	2016	Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.	Paraffin	83-91	notch receptor 1	Homo sapiens	23-29
26611647-4	2016	Immunochemistry was used to evaluate BAP1 expression in a large cohort of 474 paraffin-embedded specimens.	Paraffin	78-86	BRCA1 associated protein 1	Homo sapiens	37-41
26961138-5	2016	Relying on extracted DNAs from the paraffin-embedded tumor samples, EGFR mutations were detected by direct sequencing.	Paraffin	35-43	epidermal growth factor receptor	Homo sapiens	68-72
27513240-0	2016	eNOS gene polymorphisms in paraffin-embedded tissues of prostate cancer patients.	Paraffin	27-35	nitric oxide synthase 3	Homo sapiens	0-4
27092059-5	2016	For this purpose, we used a highly sensitive immunohistochemistry (IHC) technique to identify tyrosine hydroxylase (TH; EC 1.14.16.2), a marker for striatal dopaminergic axons and terminals, in formalin-fixed paraffin-embedded (FFPE) tissues obtained from autopsied human brains.	Paraffin	209-217	tyrosine hydroxylase	Homo sapiens	94-114
27092059-5	2016	For this purpose, we used a highly sensitive immunohistochemistry (IHC) technique to identify tyrosine hydroxylase (TH; EC 1.14.16.2), a marker for striatal dopaminergic axons and terminals, in formalin-fixed paraffin-embedded (FFPE) tissues obtained from autopsied human brains.	Paraffin	209-217	tyrosine hydroxylase	Homo sapiens	116-118
26626802-0	2016	Droplet digital polymerase chain reaction detection of HER2 amplification in formalin fixed paraffin embedded breast and gastric carcinoma samples.	Paraffin	92-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
26944829-4	2016	Confocal immunofluorescence of formalin and paraffin-embedded tissue was used to access the subcellular localization of EGFR.	Paraffin	44-52	epidermal growth factor receptor	Canis lupus familiaris	120-124
26782630-4	2016	The expression and significance of IDH2 were investigated by immunohistochemistry in formalin-fixed paraffin sections from 44 osteosarcoma patients.	Paraffin	100-108	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	35-39
26891729-1	2016	therascreen( ) EGFR RGQ PCR Kit is a real-time polymerase chain reaction test kit for the qualitative detection of exon 19 deletions and L858R mutation of the human EGFR gene in formalin-fixed paraffin-embedded non-small cell lung cancer (NSCLC) tissue.	Paraffin	193-201	epidermal growth factor receptor	Homo sapiens	15-19
26891729-1	2016	therascreen( ) EGFR RGQ PCR Kit is a real-time polymerase chain reaction test kit for the qualitative detection of exon 19 deletions and L858R mutation of the human EGFR gene in formalin-fixed paraffin-embedded non-small cell lung cancer (NSCLC) tissue.	Paraffin	193-201	epidermal growth factor receptor	Homo sapiens	165-169
27053957-3	2016	MATERIALS AND METHODS: Expression of EGFR, c-Met, and HER2 protein was detected by immunohistochemistry (IHC) in 180 paraffin-embedded tissue samples from stage IIB-IIIC ESCC patients.	Paraffin	117-125	epidermal growth factor receptor	Homo sapiens	37-41
27053957-3	2016	MATERIALS AND METHODS: Expression of EGFR, c-Met, and HER2 protein was detected by immunohistochemistry (IHC) in 180 paraffin-embedded tissue samples from stage IIB-IIIC ESCC patients.	Paraffin	117-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-58
27065677-5	2016	Immunohistochemistry (IHC) was carried out on all the cases to evaluate the expression of HER2 in formalin-fixed paraffin-embedded tissue samples.	Paraffin	113-121	erb-b2 receptor tyrosine kinase 2	Homo sapiens	90-94
26944953-2	2016	The expression of Lin28A and AR in formalin-fixed and paraffin-embedded surgical sections from 305 patients with ER-/Her2+ breast cancer was analyzed by immunohistochemistry, and the co-expression patterns in breast cancer cells were investigated by immunofluorescent staining.	Paraffin	54-62	lin-28 homolog A	Homo sapiens	18-24
26535981-7	2016	Immunohistochemistry for GHRH-R was performed on paraffin sections and the staining results were evaluated separately in both epithelial and mesenchymal components of each tumor.	Paraffin	49-57	growth hormone releasing hormone receptor	Homo sapiens	25-31
25475092-6	2016	Immunocytochemical staining of paraffin sections of muscle infected by T. spiralis enabled us to localize some orthologues of the human PDIs (PDIA3 and TMX1) and the chaperone GRP78.	Paraffin	31-39	protein disulfide isomerase family A member 3	Homo sapiens	142-147
26893746-4	2016	In the present study, the expression and activity of RhoA was evaluated in 34 paraffin-embedded and 20 frozen prostate tissue specimens obtained from 45 patients treated with radical prostatectomy for clinically localised cancer.	Paraffin	78-86	ras homolog family member A	Homo sapiens	53-57
26882358-4	2016	This is the first case of Denys Drash Syndrome with the uncommon missense c.1097G&gt;A [p.(Arg366His)] mutation in the WT1 gene which has been diagnosed on long-term stored formalin-fixed paraffin-embedded tissue in 1993.	Paraffin	188-196	WT1 transcription factor	Homo sapiens	119-122
27146728-3	2016	MATERIALS AND METHODS: Expression levels of TSLC1 were detected by immunohistochemical staining on formal-fixed paraffin embedded pathological specimen.	Paraffin	112-120	cell adhesion molecule 1	Homo sapiens	44-49
27323551-6	2016	Immuno-histochemical staining for P53 performed on paraffin blocks and quantified with 12- point weighted score proposed by W.Y chan.	Paraffin	51-59	tumor protein p53	Homo sapiens	34-37
27660801-10	2016	For both paraffin sections and frozen sections of pigmented tissues, purple VIP substrate is an excellent alternative to brown DAB substrate and non-permanent immunofluorescence methods.	Paraffin	9-17	vasoactive intestinal peptide	Homo sapiens	76-79
25475092-6	2016	Immunocytochemical staining of paraffin sections of muscle infected by T. spiralis enabled us to localize some orthologues of the human PDIs (PDIA3 and TMX1) and the chaperone GRP78.	Paraffin	31-39	heat shock protein family A (Hsp70) member 5	Homo sapiens	176-181
26820945-0	2016	Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).	Paraffin	112-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-54
26202929-0	2016	A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies.	Paraffin	86-94	calbindin 2	Homo sapiens	27-31
26202929-0	2016	A new monoclonal antibody (CAL2) detects CALRETICULIN mutations in formalin-fixed and paraffin-embedded bone marrow biopsies.	Paraffin	86-94	calreticulin	Homo sapiens	41-53
26820945-0	2016	Evaluation of Human Epidermal Growth Factor Receptor 2 (HER2) Gene Status in Human Breast Cancer Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens by Fluorescence In Situ Hybridization (FISH).	Paraffin	112-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-60
26422389-3	2016	METHODS: Using selected reaction monitoring mass spectrometry (SRM-MS), we quantified HER2 protein levels in formalin-fixed, paraffin-embedded (FFPE) tissue samples that had been classified as HER2 0, 1+, 2+ or 3+ by immunohistochemistry (IHC).	Paraffin	125-133	erb-b2 receptor tyrosine kinase 2	Homo sapiens	86-90
26335532-4	2016	The patients were genotyped by classical sequencing, and mTOR pathway activity was assessed by immunochemistry on formalin-fixed paraffin-embedded samples (PTEN/pPTEN/pAKT/pmTOR/pS6/p4EBP1).	Paraffin	129-137	mechanistic target of rapamycin kinase	Homo sapiens	57-61
26870241-3	2016	HSP and P-glycoprotein (the MDR1 gene product) expression was evaluated by immunohistochemical analysis of paraffin-embedded sections obtained from 37 patients with chondrosarcoma (19 male and 18 female; aged 33-85 years; mean age, 48.5 years).	Paraffin	107-115	ATP binding cassette subfamily B member 1	Homo sapiens	28-32
27020207-6	2016	The PIK3CA mutation was evaluated using the PNAClamp Detection Kit from DNA samples extracted from formalin fixed, paraffin embedded tissue.	Paraffin	115-123	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	4-10
27516024-2	2016	The aim of this study was to identify patients with EGFR mutations using allele-specific polymerase chain reaction (PCR), from formalin-fixed paraffin-embedded (FFPE) tissue and fresh tissue (FT).	Paraffin	142-150	epidermal growth factor receptor	Homo sapiens	52-56
26498465-3	2016	HuR and COX-2 proteins" expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 98 patients with benign (n = 48) and malignant (n = 50) lesions and was statistically analyzed with clinicopathological parameters, follicular cells" proliferative capacity and recurrence risk rate.	Paraffin	73-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	8-13
26673410-2	2015	The aim of this study was to develop an immunohistochemistry (IHC) assay to assess GR expression in archival formalin-fixed, paraffin-embedded human invasive breast carcinoma samples.	Paraffin	125-133	nuclear receptor subfamily 3 group C member 1	Homo sapiens	83-85
27562390-6	2016	In the present study, microvessel density was determined by immunohistochemical staining by using anti-CD34 monoclonal antibody in the paraffin blocks.	Paraffin	135-143	CD34 molecule	Homo sapiens	103-107
26240388-6	2015	To demonstrate the clinical applicability of our assay, we show specific detection of a point mutation in the EGFR gene in fresh frozen and formalin-fixed, paraffin-embedded (FFPE) lung cancer samples and confirm the detected mutation by in situ sequencing.	Paraffin	156-164	epidermal growth factor receptor	Homo sapiens	110-114
26631948-2	2016	Mutations in exon 11 of c-KIT were examined in 46 formalin-fixed paraffin-embedded canine GISTs using PCR of genomic DNA and reverse transcription-PCR (RT-PCR) of cDNA.	Paraffin	65-73	KIT proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	24-29
26001593-6	2015	As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis.	Paraffin	259-267	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	78-84
26554593-3	2015	METHODS: Gankyrin expression was assessed using immunohistochemical (IHC) methods in 166 paired paraffin-embedded NSCLC specimens and adjacent normal tissues.	Paraffin	96-104	proteasome 26S subunit, non-ATPase 10	Homo sapiens	9-17
26407762-0	2015	Multi-center evaluation of the novel fully-automated PCR-based Idylla  BRAF Mutation Test on formalin-fixed paraffin-embedded tissue of malignant melanoma.	Paraffin	108-116	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	71-75
26884876-4	2015	IFITM1 expression was analyzed in 144 archived, paraffin-embedded colorectal cancer tissues and corresponding normal colorectal mucosa by immunohistochemistry.	Paraffin	48-56	interferon induced transmembrane protein 1	Homo sapiens	0-6
26001593-6	2015	As a proof of the concept, we present the case of a metastatic patient with a PIK3CA wild-type primary tumor in which the PIK3CA E545K mutation was identified in both the circulating-free DNA obtained from a peripheral blood sample and in the formalin-fixed, paraffin-embedded liver metastasis.	Paraffin	259-267	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	122-128
26430961-4	2015	We then validated the CAD expression in BC cells by immunohistochemistry analysis using paraffin-embedded tissue blocks and western blots using BC cell lines.	Paraffin	88-96	caldesmon 1	Homo sapiens	22-25
26788216-2	2015	Gal-7 expression was immunohistochemically detected in the paraffin-embedded sections of 20 normal vulvar biopsy samples and 50 VSCC specimens.	Paraffin	59-67	galectin 7	Homo sapiens	0-5
26459371-3	2015	MATERIALS AND METHODS: We have analysed the immunohistochemical expression of Twist1 and Snai2, two of the most important transcription factors involved in epithelial to mesenchymal transition, in formalin-fixed paraffin-embedded samples of 23 spontaneous abortive pregnancies, 22 molar pregnancies (10 partial and 12 complete) and 7 term placentas.	Paraffin	212-220	twist family bHLH transcription factor 1	Homo sapiens	78-84
26578846-3	2015	The expression of the cell surface protein CD24 has already been claimed to be associated with shorter patient survival in non-small cell lung cancer (NSCLC), however, the prognostic value and applicability of CD24 immunostaining in paraffin embedded tissue specimens has been questioned due to the recent acknowledgement of restricted epitope specificity of the commonly used antibody SN3b.	Paraffin	233-241	CD24 molecule	Homo sapiens	43-47
26578846-3	2015	The expression of the cell surface protein CD24 has already been claimed to be associated with shorter patient survival in non-small cell lung cancer (NSCLC), however, the prognostic value and applicability of CD24 immunostaining in paraffin embedded tissue specimens has been questioned due to the recent acknowledgement of restricted epitope specificity of the commonly used antibody SN3b.	Paraffin	233-241	CD24 molecule	Homo sapiens	210-214
26702420-7	2015	[1], it was used for multiplex scanning PIK3CA hotspot mutations in formalin-fixed paraffin-embedded (FFPE) samples from patients with colorectal and lung cancer.	Paraffin	83-91	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	40-46
26452130-3	2015	We found that CTHRC1 expression was up-regulated in the paraffin-embedded EOC tissues compared to borderline or benign tumor tissues.	Paraffin	56-64	collagen triple helix repeat containing 1	Homo sapiens	14-20
26557914-5	2015	METHODS: Expression levels of CaSR and E-cadherin in paraffin sections from 117 resected lung adenocarcinoma patients were evaluated by immunohistochemistry.	Paraffin	53-61	calcium sensing receptor	Homo sapiens	30-34
26557914-5	2015	METHODS: Expression levels of CaSR and E-cadherin in paraffin sections from 117 resected lung adenocarcinoma patients were evaluated by immunohistochemistry.	Paraffin	53-61	cadherin 1	Homo sapiens	39-49
26484710-0	2015	Employing Digital Droplet PCR to Detect BRAF V600E Mutations in Formalin-fixed Paraffin-embedded Reference Standard Cell Lines.	Paraffin	79-87	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	40-44
26622810-5	2015	Cell surface and cytoplasmic expression of GRP78 was examined by immunohistochemical staining of GRP78 in breast cancer archival paraffin-embedded tumor specimens.	Paraffin	129-137	heat shock protein family A (Hsp70) member 5	Homo sapiens	43-48
25920992-1	2015	INTRODUCTION: Recent studies have proposed that FXYD3 and KRT20 mRNA quantified by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in paraffin could be biomarkers to detect lymph nodes with micrometastases that avoid detection by conventional analysis with hematoxylin-eosin (HE).	Paraffin	157-165	FXYD domain containing ion transport regulator 3	Homo sapiens	48-53
25920992-1	2015	INTRODUCTION: Recent studies have proposed that FXYD3 and KRT20 mRNA quantified by quantitative reverse transcription polymerase chain reaction (qRT-PCR) in paraffin could be biomarkers to detect lymph nodes with micrometastases that avoid detection by conventional analysis with hematoxylin-eosin (HE).	Paraffin	157-165	keratin 20	Homo sapiens	58-63
26036704-5	2015	After a 100-day cultivation, the paraffin reactor showed almost two times higher consumption rates of NO3 (-) (0.2268 mmol/day) and NH4 (+) (0.1403 mmol/day), compared to the control reactor without paraffin oil.	Paraffin	33-41	NBL1, DAN family BMP antagonist	Homo sapiens	102-105
26622790-6	2015	Immunohistochemical analysis for TBX5 expression was performed on 161 paraffin-embedded stage I and II GC tissue blocks.	Paraffin	70-78	T-box transcription factor 5	Homo sapiens	33-37
26149442-0	2015	Quantification of HER2 by Targeted Mass Spectrometry in Formalin-Fixed Paraffin-Embedded (FFPE) Breast Cancer Tissues.	Paraffin	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-22
26149442-2	2015	We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors.	Paraffin	147-155	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-121
26149442-2	2015	We have developed and evaluated a selectedreaction monitoring assay for the human receptor tyrosine-protein kinase erbB-2 (HER2) in formalin-fixed paraffin-embedded breast tumors.	Paraffin	147-155	erb-b2 receptor tyrosine kinase 2	Homo sapiens	123-127
26149442-6	2015	The six HER2 peptides were quantified by selected reaction monitoring in a cohort of 40 archival formalin-fixed paraffin-embedded tumor tissues from women with invasive breast carcinomas, which showed different levels of HER2 gene amplification as assessed by standard methods used in clinical pathology.	Paraffin	112-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	8-12
26149442-7	2015	The amounts of the six HER2 peptides were highly and significantly correlated with each other, indicating that peptide levels can be used as surrogates of protein amounts in formalin-fixed paraffin-embedded tissues.	Paraffin	189-197	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
26564508-0	2015	[Application of Immunohistochemistry and Immunofluorescence Staining in Detection of Phospholipase A2 Receptor on Paraffin Section of Renal Biopsy Tissue].	Paraffin	114-122	phospholipase A2 group IB	Homo sapiens	85-101
26330075-3	2015	We used Idylla to detect BRAF V600 mutations in archived formalin-fixed paraffin-embedded (FFPE) tumor samples and compared these results with those obtained using the cobas 4800 BRAF V600 Mutation Test or MiSeq deep sequencing system and with those obtained by a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory employing polymerase chain reaction-based sequencing, mass spectrometric detection, or next-generation sequencing.	Paraffin	72-80	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	25-29
25907264-6	2015	We demonstrate histopathological findings and confirm the HEY1-NCOA2 gene fusion in a formalin-fixed paraffin-embedded archival sample using simple reverse transcription polymerase chain reaction (RT-PCR) method.	Paraffin	101-109	hes related family bHLH transcription factor with YRPW motif 1	Homo sapiens	58-62
26366212-2	2015	We examined Eps15 homology domain 1 (EHD1) protein expression in paraffin sections of 85 resected SCLC tissues, metastatic lymph nodes and normal bronchial epithelial tissues using immunohistochemistry to study the correlation between EHD1 expression and patient clinicopathological features.	Paraffin	65-73	epidermal growth factor receptor pathway substrate 15	Homo sapiens	12-17
26193797-4	2015	We evaluated the expression of Abi1 in 223 paraffin-embedded EOC specimens by immunohistochemistry and 46 frozen EOC samples by Western blot and real-time reverse transcription polymerase chain reaction analysis.	Paraffin	43-51	abl interactor 1	Homo sapiens	31-35
26283398-7	2015	L1 proteins must be expressed for retrotransposition to occur; therefore, we evaluated the expression of open reading frame 1 protein (ORF1p), a protein encoded by L1, in eight of the EAC cases for which formalin-fixed paraffin embedded tissue was available.	Paraffin	219-227	ORF1	Homo sapiens	135-140
26713526-2	2015	METHODS: The expression of Cx26 in liver tissue was examined by immunohistochemistry staining in 159 paraffin-embeded liver sections, including 20 samples of normal liver tissue, 30 samples of chronic hepatitis, 33 samples of liver cirrhosis, and 76 samples of HCC.	Paraffin	101-109	gap junction protein beta 2	Homo sapiens	27-31
26311318-3	2015	Expression of Hoxd10 protein in 436 paraffin-embedded cancer tissues was also investigated.	Paraffin	36-44	homeobox D10	Homo sapiens	14-20
26366212-2	2015	We examined Eps15 homology domain 1 (EHD1) protein expression in paraffin sections of 85 resected SCLC tissues, metastatic lymph nodes and normal bronchial epithelial tissues using immunohistochemistry to study the correlation between EHD1 expression and patient clinicopathological features.	Paraffin	65-73	EH domain containing 1	Homo sapiens	37-41
25898889-4	2015	The utility of immunohistochemical staining using an antibody directed against apoE4 in paraffin-embedded tissue was also evaluated.	Paraffin	88-96	apolipoprotein E	Homo sapiens	79-84
25901506-3	2015	CIAPIN1 protein expression was detected in 32 samples of paraffin-embedded MM and adjacent healthy bone marrow tissue using immunohistochemistry.	Paraffin	57-65	cytokine induced apoptosis inhibitor 1	Homo sapiens	0-7
25716692-9	2015	The expression levels of BPTF and vimentin in CRC paraffin-embedded specimens were significantly higher than the expression in NATs (P &lt; 0.01), while the expressions of E-cadherin in tumors were obviously lower than in NATs (P &lt; 0.01).	Paraffin	50-58	bromodomain PHD finger transcription factor	Homo sapiens	25-29
26379923-0	2015	Over-expression of miR-675 in formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer patients.	Paraffin	45-53	microRNA 675	Homo sapiens	19-26
26186215-3	2015	METHODS: A multiple immunofluorescence technique was employed to concomitantly and quantitatively visualize the nuclear localization of p65 and RelB in 200 paraffin embedded samples.	Paraffin	156-164	RELB proto-oncogene, NF-kB subunit	Homo sapiens	144-148
26379923-12	2015	CONCLUSIONS: Taken together, our study demonstrated that miR-675 in formalin-fixed paraffin-embedded (FFPE) tissues might serve as a good source for biomarker discovery and breast cancer validation.	Paraffin	83-91	microRNA 675	Homo sapiens	57-64
25952101-5	2015	Our aim was to evaluate the clinical routine performance of a new dPCR-based test to detect and quantify BRAF mutation load in 47 paraffin-embedded cutaneous melanoma biopsies.	Paraffin	130-138	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	105-109
25517872-2	2015	The aim of this study was to investigate the use of a recently developed mutation-specific antibody (VE1; SpringBio, Pleasanton, CA) to detect the BRAF V600E protein in paraffin tissue.	Paraffin	169-177	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	147-151
25479940-5	2015	METHODS: Immunohistochemical staining of myeloperoxidase and CD44v9 was performed using paraffin-embedded tissue sections obtained from 54 patients who underwent gastric resection without preoperative treatment.	Paraffin	88-96	myeloperoxidase	Homo sapiens	41-56
26070193-2	2015	We examined the expression of PC by immunohistochemistry of paraffin-embedded breast tissue sections of 57 breast cancer patients with different stages of cancer progression.	Paraffin	60-68	pyruvate carboxylase	Homo sapiens	30-32
25663493-4	2015	Protein expression levels of PTPN12 were explored by semiquantitative immunohistochemical staining on archival formalin-fixed, paraffin-embedded pathological specimens consisting of 203 NPCs, and 40 normal nasopharyngeal mucosa tissues.	Paraffin	127-135	protein tyrosine phosphatase non-receptor type 12	Homo sapiens	29-35
26081767-1	2015	BACKGROUND: The purpose of this study was to develop a cost-effective approach for the determination of EGFR and KRAS mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) samples from Chinese patients based on a sensitive pyrosequencing (PS) technique.	Paraffin	146-154	epidermal growth factor receptor	Homo sapiens	104-108
26086362-3	2015	METHODS: A quantitative multiplex, methylation-specific PCR assay was developed to assess promoter methylation of the APC, CCND2, GSTP1, PTGS2 and RARB genes in formalin-fixed, paraffin-embedded tissue samples from 42 patients with benign prostatic hyperplasia and radical prostatectomy specimens of patients with high-risk PCa, encompassing training and validation cohorts of 147 and 71 patients, respectively.	Paraffin	177-185	prostaglandin-endoperoxide synthase 2	Homo sapiens	137-142
26086362-3	2015	METHODS: A quantitative multiplex, methylation-specific PCR assay was developed to assess promoter methylation of the APC, CCND2, GSTP1, PTGS2 and RARB genes in formalin-fixed, paraffin-embedded tissue samples from 42 patients with benign prostatic hyperplasia and radical prostatectomy specimens of patients with high-risk PCa, encompassing training and validation cohorts of 147 and 71 patients, respectively.	Paraffin	177-185	retinoic acid receptor beta	Homo sapiens	147-151
25825818-6	2015	Paraffin-embedded UA rings were used to localize CBS and CSE proteins by immunofluorescence microscopy.	Paraffin	0-8	cystathionine beta-synthase	Homo sapiens	49-52
25883126-8	2015	The expression of norepinephrine transporter (NET) and vesicular monoamine transporter (VMAT-1) was evaluated immunohistochemically in paraffin-embedded tumor tissues.	Paraffin	135-143	solute carrier family 6 member 2	Homo sapiens	18-44
25863425-0	2015	Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks.	Paraffin	96-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-39
25863425-0	2015	Clinical significance of assessing Her2/neu expression in gastric cancer with dual tumor tissue paraffin blocks.	Paraffin	96-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-43
25863425-1	2015	One paraffin block is routinely used for human epidermal growth factor receptor 2 (Her2/neu) immunohistochemistry (IHC) assessment.	Paraffin	4-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-81
25863425-1	2015	One paraffin block is routinely used for human epidermal growth factor receptor 2 (Her2/neu) immunohistochemistry (IHC) assessment.	Paraffin	4-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-91
26255449-5	2015	MATERIAL AND METHODS: Caveolin-1 expression was studied in a total of 82 formalin-fixed, paraffin-embedded specimens of ovarian serous tumors and its association with different clinicopathologic parameters was evaluated.	Paraffin	89-97	caveolin 1	Homo sapiens	22-32
25863425-2	2015	Here, we investigated if picking 2 paraffin blocks for Her2/neu evaluation on 1 slide is an economical, efficient, and practical method, which may reduce false negativity of Her2/neu IHC assessment due to intratumoral heterogeneity.	Paraffin	35-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
25863425-2	2015	Here, we investigated if picking 2 paraffin blocks for Her2/neu evaluation on 1 slide is an economical, efficient, and practical method, which may reduce false negativity of Her2/neu IHC assessment due to intratumoral heterogeneity.	Paraffin	35-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	174-178
25863425-9	2015	Our results implied that using dual paraffin blocks to assess Her2/neu expression of GC may help identify more patients with Her2/neu-positive GC who could benefit from targeted therapy, by reducing false-negative rate of Her2 status assessment.	Paraffin	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-66
25863425-9	2015	Our results implied that using dual paraffin blocks to assess Her2/neu expression of GC may help identify more patients with Her2/neu-positive GC who could benefit from targeted therapy, by reducing false-negative rate of Her2 status assessment.	Paraffin	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	62-70
25863425-9	2015	Our results implied that using dual paraffin blocks to assess Her2/neu expression of GC may help identify more patients with Her2/neu-positive GC who could benefit from targeted therapy, by reducing false-negative rate of Her2 status assessment.	Paraffin	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
26261610-5	2015	In this study, PCBP1 expression was evaluated by Western blot in 8 fresh lung cancer tissues and immunohistochemistry (IHC) on 145 paraffin-embedded slices.	Paraffin	131-139	poly(rC) binding protein 1	Homo sapiens	15-20
26191231-4	2015	MATERIALS AND METHODS: Immunohistochemistry was used to assess the level of XB130 protein in surgically resected, formalin-fixed, paraffin-embedded breast cancer specimens.	Paraffin	130-138	actin filament associated protein 1 like 2	Homo sapiens	76-81
26060153-7	2015	RESULTS: There were 49 paraffin blocks in the study.Significant correlations were found between cyclooxygenase-2 and tumour subtype (p=0.044) as well as between cyclooxygenase-2 and tumour diameter (p=0.026).	Paraffin	23-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-112
26060153-7	2015	RESULTS: There were 49 paraffin blocks in the study.Significant correlations were found between cyclooxygenase-2 and tumour subtype (p=0.044) as well as between cyclooxygenase-2 and tumour diameter (p=0.026).	Paraffin	23-31	prostaglandin-endoperoxide synthase 2	Homo sapiens	161-177
26022247-13	2015	CONCLUSIONS: We conclude that the SNP assay is suitable for rapid testing of allelic (im)balance at the HER2/TOP2A locus using paraffin-embedded tissues.	Paraffin	127-135	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-108
25934889-3	2015	EXPERIMENTAL DESIGN: An ITK-specific monoclonal antibody was used to probe sections from deidentified, formalin-fixed paraffin-embedded tumor blocks or cell line arrays and ITK was visualized by IHC.	Paraffin	118-126	IL2 inducible T cell kinase	Mus musculus	24-27
26214636-4	2015	METHODS: The immunohistochemical (IHC) expression of CD10, BCL6, MUM1 and BCL2 on paraffin-embedded formalin-fixed tumor samples from 103 centroblastic DLBCLs was analyzed.	Paraffin	82-90	BCL2 apoptosis regulator	Homo sapiens	74-78
26175941-4	2015	Furthermore, protein level of NDC80 was identified using immunochemistry in paraffin-embedded tumor specimen, with correlation between NDC80 expression and various clinicopathological parameters evaluated.	Paraffin	76-84	NDC80 kinetochore complex component	Homo sapiens	30-35
26604484-13	2015	The immunohistochemistry was carried out on neutral buffered formalin-fixed paraffin-embedded tissue sections by using the monoclonal antibody of HIF-1alpha.	Paraffin	76-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	146-156
25536018-4	2015	Here, a DNA-based EpCAM aptamer SYL3C is reported as a probe for the immunostaining of frozen and paraffin-embedded sections of colorectal cancer tissues.	Paraffin	98-106	epithelial cell adhesion molecule	Homo sapiens	18-23
26411101-7	2015	Twist expression of these tumours was estimated by immunohistochemistry, performed on paraffin sections.	Paraffin	86-94	twist family bHLH transcription factor 1	Homo sapiens	0-5
25568185-5	2015	Finally, we validated RacGAP1 protein expression using formalin-fixed paraffin-embedded samples from 298 CRC patients (Cohort 2) by immunohistochemistry.	Paraffin	70-78	Rac GTPase activating protein 1	Homo sapiens	22-29
25679210-4	2015	METHODS: In the present study, immunohistochemical staining of EGFR and CXCR4 was performed on paraffin-embedded specimens from 131 patients with surgically resected PDAC.	Paraffin	95-103	epidermal growth factor receptor	Homo sapiens	63-67
25651992-7	2015	After pathological diagnoses of NSCLC, EGFR mutation status in formalin-fixed, paraffin- embedded samples was confirmed by the PCR-invader method, and the concordance rates between the PCR methods were compared.	Paraffin	79-87	epidermal growth factor receptor	Homo sapiens	39-43
26122241-1	2015	This study quantified the expression of Y-box binding protein 1 (YB-1) by the immunohistochemical method based on pathological paraffin block specimens of aspiration biopsy from patients with osteosarcoma to explore the influence and regulatory mechanism of YB-1 in osteosarcoma and its significance.	Paraffin	127-135	Y-box binding protein 1	Homo sapiens	40-63
26122241-1	2015	This study quantified the expression of Y-box binding protein 1 (YB-1) by the immunohistochemical method based on pathological paraffin block specimens of aspiration biopsy from patients with osteosarcoma to explore the influence and regulatory mechanism of YB-1 in osteosarcoma and its significance.	Paraffin	127-135	Y-box binding protein 1	Homo sapiens	65-69
25948218-10	2015	CONCLUSION: Immunohistochemical tests for BRAF V600E in Paraffin-embedded tissue is of ideal sensitivity, 58% Chinese LCH patients have BRAF V600E positive and so LCH is a clonal disease but the exact role of BRAF V600E in LCH needs further research.	Paraffin	56-64	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	42-46
25948218-10	2015	CONCLUSION: Immunohistochemical tests for BRAF V600E in Paraffin-embedded tissue is of ideal sensitivity, 58% Chinese LCH patients have BRAF V600E positive and so LCH is a clonal disease but the exact role of BRAF V600E in LCH needs further research.	Paraffin	56-64	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	136-140
25948218-10	2015	CONCLUSION: Immunohistochemical tests for BRAF V600E in Paraffin-embedded tissue is of ideal sensitivity, 58% Chinese LCH patients have BRAF V600E positive and so LCH is a clonal disease but the exact role of BRAF V600E in LCH needs further research.	Paraffin	56-64	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	136-140
25848214-4	2015	Paraffin blocks from 48 HCC patients were used to detect ADAMTS5 and vascular endothelial growth factor (VEGF) expression and microvessel density (MVD).	Paraffin	0-8	vascular endothelial growth factor A	Homo sapiens	69-103
25588809-7	2015	We immunohistochemically evaluated Nrf2 expression in the paraffin-embedded surgically resected specimens of these 175 patients.	Paraffin	58-66	NFE2 like bZIP transcription factor 2	Homo sapiens	35-39
25659388-5	2015	METHODS AND MATERIALS: In this retrospective study, we performed polymerase chain reaction (PCR) amplification and deoxyribonucleic acid (DNA) sequencing of KIT (exons 9, 11, 13, and 17) and PDGFRA (exons 12 and 18) genes in 20 FFPE (formalin-fixed, paraffin-embedded) and 5 frozen GIST samples.	Paraffin	250-258	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	157-160
25640361-7	2015	Immunohistochemical expression of p16 INK4A was analyzed in pretreatment paraffin-embedded tumor blocks.	Paraffin	73-81	cyclin dependent kinase inhibitor 2A	Homo sapiens	34-37
26160036-4	2015	METHODS: The expression levels of miR-495 was examined in 62 archival formalin-fixed paraffin-embedded (FFPE) medulloblastoma specimens using TaqMan Real-time Quantitative PCR arrays.	Paraffin	85-93	microRNA 495	Homo sapiens	34-41
26539529-3	2015	CB1 and CB2 proteins" expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 87 patients with benign (n = 43) and malignant (n = 44) lesions and was statistically analyzed with clinicopathological parameters, follicular cells" proliferative capacity, and risk of recurrence rate estimated according to the American Thyroid Association (ATA) staging system.	Paraffin	71-79	cannabinoid receptor 1	Homo sapiens	0-3
25569410-8	2015	Thyroglobulin and thyroid transcription factor 1 stains displayed a strong staining on paraffin block.	Paraffin	87-95	NK2 homeobox 1	Homo sapiens	18-48
25473754-4	2015	Immunohistochemistry for p53 was performed on all paraffin blocks of fallopian tube and non-neoplastic endometrium.	Paraffin	50-58	tumor protein p53	Homo sapiens	25-28
25525358-4	2014	MATERIALS AND METHODS: EGFR gene mutations were detected by QDs-IHC, IHC, and ADx-ARMS in 65 cases of NSCLC composed of 55 formalin-fixed, paraffin-embedded specimens and ten pleural effusion cell blocks, including 13 squamous cell carcinomas, two adenosquamous carcinomas, and 50 adenocarcinomas.	Paraffin	139-147	epidermal growth factor receptor	Homo sapiens	23-27
25973151-6	2015	Immunohistochemical analysis of CrkII expression was performed on paraffin blocks of 64 car-cinomas of salivary glands, 10 pleomorphic adenomas, and 10 normal salivary glands.	Paraffin	66-74	CRK proto-oncogene, adaptor protein	Homo sapiens	32-37
25797291-4	2015	The expression of TLR4 and TLR5 was evaluated by immunohistochemisty in formalin-fixed paraffin-embedded prostate tissue from wild-type (WT) and TRAMP mice.	Paraffin	87-95	toll-like receptor 4	Mus musculus	18-22
26429165-4	2015	Paraffin sections were immunostained with antibodies against CD56, VEGF-A and CD34 using an Avidin-Biotin-Peroxidase technique.	Paraffin	0-8	CD34 molecule	Homo sapiens	78-82
26103892-4	2015	We identified five different BRAF mutations in a single assay analyzing 75 different formalin-fixed paraffin-embedded samples of cutaneous melanoma metastases from 29 patients.	Paraffin	100-108	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	29-33
25779069-4	2015	In 202 paraffin-embedded OTSCC samples, BATF2 was not expressed in 20 cases (9.9%), low expressed in 104 cases (51.5%) and highly expressed in 78 (38.6%).	Paraffin	7-15	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	40-45
25182852-4	2014	The expression of HuR and estrogen receptor alpha (ER-alpha) protein was examined by immunohistochemistry on paraffin embedding specimens containing endometrial carcinoma and adjacent non-cancerous tissues.	Paraffin	109-117	estrogen receptor 1	Homo sapiens	51-59
25118810-10	2014	Unfavorable risk cases potentially also responding to BRAF-inhibitory therapy can be identified by mutation testing using archival formaldehyde-fixed, paraffin-embedded tumor samples.	Paraffin	151-159	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	54-58
25236569-2	2014	In the present study, the BrightGen HER2 RT-qDx (Syantra, Calgary, Canada), which is based on a one-tube nested RT-qPCR method that detects HER2 mRNA overexpression, was clinically evaluated in a total of 237 formalin-fixed paraffin-embedded (FFPE) tissue samples from breast cancer patients.	Paraffin	224-232	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-40
25674250-4	2014	In the 22 matched samples, 13 cases of EGFR mutations were identified in paraffin-embedded biopsy tissue samples, 12 cases in the cell-free supernatant and 9 cases in the cell pellets of pleural effusion.	Paraffin	73-81	epidermal growth factor receptor	Homo sapiens	39-43
25674264-2	2014	METHODS: The immunohistochemical expression of p15(INK4b), p16(INK4a) and p21(Waf1/Cip1) were investigated in formalin-fixed paraffin-embedded specimens from 19 NCE, 51 CIN and 21 SCC cases, respectively.	Paraffin	125-133	cyclin dependent kinase inhibitor 2B	Homo sapiens	47-50
25674237-6	2014	In this study, the expression of YB-1 was examined in 32 fresh CRC tissues using quantitative real-time polymerase chain reaction (qRT-PCR) and in 170 paraffin-embedded CRC tissues using immunohistochemistry.	Paraffin	151-159	Y-box binding protein 1	Homo sapiens	33-37
25543707-2	2014	METHODS: The levels of TNF-alpha in paraffin tissue or plasma samples were detected by immunohistochemistry or ELISA assay in 88 lymphoma patients and 88 healthy controls.	Paraffin	36-44	tumor necrosis factor	Homo sapiens	23-32
25135238-7	2014	The TP53 genotype was assessed from paraffin-embedded diagnostic tumor biopsies using a standardized gene-specific TP53 sequencing protocol (mark53 kit; mark53 Ltd, Vienna, Austria).	Paraffin	36-44	tumor protein p53	Homo sapiens	4-8
25623974-3	2014	Polymerase chain reaction was used to amplify exon 15 of the BRAF gene from paraffin-embedded thyroid tumor specimens, followed by direct sequencing to detect the BRAF V600E mutation.	Paraffin	76-84	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	61-65
24630684-4	2014	ERG immunohistochemical staining was performed on diagnostic paraffin-embedded formalin-fixed sections with a ready-to-use kit (anti-ERG, EPR3864).	Paraffin	61-69	ETS transcription factor ERG	Homo sapiens	0-3
25279206-5	2014	HER-2 was detected by immunohistochemical examination on sections from formalin-fixed, paraffin-embedded tumor tissues.	Paraffin	87-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
25262426-4	2014	Immunohistochemical analysis of EZH2 on the paraffin-embedded pre-treatment tumor samples was performed and correlated with chemotherapy response and survival.	Paraffin	44-52	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	32-36
25263855-2	2014	EGFR mutations are commonly tested by Sanger sequencing or allele specific polymerase chain reaction (ASPCR) on formalin-fixed paraffin-embedded (FFPE) samples including cell blocks (CB) that may fail due to absence of tumor cells.	Paraffin	127-135	epidermal growth factor receptor	Homo sapiens	0-4
25239421-0	2014	Quantitative analysis of ERG expression and its splice isoforms in formalin-fixed, paraffin-embedded prostate cancer samples: association with seminal vesicle invasion and biochemical recurrence.	Paraffin	83-91	ETS transcription factor ERG	Homo sapiens	25-28
25204501-8	2014	Consistent with these observations, immunohistochemical (IHC) staining revealed that AEG-1 expression was associated with the protein levels of phosphor-c-Jun and MMP-2 in needle biopsy paraffin-embedded archival human osteosarcoma tissues.	Paraffin	186-194	metadherin	Homo sapiens	85-90
25295105-2	2014	The expression of TGF-beta1 protein was detected in paraffin-embedded sections of 25 normal ovarian epithelial tissues, 10 benign epithelial cysts and 72 epithelial ovarian cancer specimens, using the Strept Avidin Biotin Peroxidase Complex immunohistochemistry method.	Paraffin	52-60	transforming growth factor beta 1	Homo sapiens	18-27
25341494-7	2014	Immunohistochemical analysis revealed high expression of TBLR1 in 113 of 214 (52.8%) paraffin-embedded archival breast cancer.	Paraffin	85-93	TBL1X/Y related 1	Homo sapiens	57-62
25238260-6	2014	Furthermore, CTHRC1 immunoreactivity was evidently overexpressed in paraffin-embedded NSCLC tissues (212/292, 72.60%) in comparison to corresponding adjacent non-cancerous tissues (6/66, 9.09%) (p&lt;0.001).	Paraffin	68-76	collagen triple helix repeat containing 1	Homo sapiens	13-19
25199759-5	2014	PIK3CA mutations were evaluated in formalin-fixed, paraffin-embedded tissues from core biopsies with a tumor cell content of &gt;= 20% by using classical Sanger sequencing of exon 9 and exon 20.	Paraffin	51-59	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	0-6
24535833-6	2014	Evidence for a role of the PARP1 protein in melanoma ulceration and survival was investigated by testing gene expression levels taken from formalin-fixed paraffin-embedded tumors.	Paraffin	154-162	poly(ADP-ribose) polymerase 1	Homo sapiens	27-32
25838812-0	2014	HER-2 assessment in formalin-fixed paraffin-embedded breast cancer tissue by well-based reverse phase protein array.	Paraffin	35-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
25838812-6	2014	By well-based RPPA, we successfully detected HER-2 expression in 76 human breast formalin-fixed paraffin-embedded tissue samples.	Paraffin	96-104	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-50
24615121-5	2014	Gene expression levels of IMP3 and its molecular target IGF2 were analyzed in 29 frozen and 26 paraffin-embedded PC tissues using real-time polymerase chain reaction and immunohistochemistry.	Paraffin	95-103	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	26-30
25202347-6	2014	In addition, immunohistochemistry (IHC) was performed to detect the p53 expression level in specimens from 118 paraffin-embedded cancerous tissues.	Paraffin	111-119	tumor protein p53	Homo sapiens	68-71
25178940-4	2014	PTX-3 overexpression was evaluated using immunohistochemistry performed on archival paraffin-embedded specimens.	Paraffin	84-92	pentraxin 3	Homo sapiens	0-5
25052332-3	2014	OBJECTIVES: The aim of this study was to immunohistochemically evaluate the expression of the cell surface antigens CD4, CD8, CD25, CD14 and CD74, in pneumonic infiltrates in the alveolar septa using paraffin-embedded lung samples from autopsies of immunocompetent children who died of lethal, non-pandemic, severe acute respiratory infections.	Paraffin	200-208	CD4 molecule	Homo sapiens	116-119
25202389-6	2014	The present study therefore aimed to retrospectively investigate TACSTD2 protein expression by immunohistochemistry on paraffin-embedded primary tumor tissue samples from a series of consecutive SACC patients (n=81).	Paraffin	119-127	tumor associated calcium signal transducer 2	Homo sapiens	65-72
25218890-3	2014	EndoPredict is a quantitative reverse transcription PCR assay conducted on RNA from formalin-fixed, paraffin-embedded (FFPE) tissue that predicts the likelihood of distant recurrence in patients with ER-positive/HER2-negative breast cancer.	Paraffin	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	212-216
25259793-4	2014	In this study, we extended our analysis of myosin IC isoform expression patterns by analyzing the protein and mRNA expression in various mammalian cell lines and in various prostate specimens and tumor tissues from the transgenic mouse prostate (TRAMP) model by immunoblotting, qRT-PCR, and by indirect immunohistochemical staining of paraffin embedded prostate specimen.	Paraffin	335-343	myosin IC	Homo sapiens	43-52
25020254-0	2014	Superior performance of decloaking chamber-based heat-induced epitope retrieval method improves the quantification of Olig2 cells in paraffin-embedded section of embryonic mouse brain.	Paraffin	133-141	oligodendrocyte transcription factor 2	Mus musculus	118-123
24820657-6	2014	E-cadherin expression was assessed on paraffin-embedded skin biopsies.	Paraffin	38-46	cadherin 1	Homo sapiens	0-10
25400755-0	2014	Quantitative RT-PCR assay of HER2 mRNA expression in formalin-fixed and paraffin-embedded breast cancer tissues.	Paraffin	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-33
25400755-6	2014	Here we employed a quantitative PCR method to detect HER2 expression in one hundred ninety nine formalin-fixed and paraffin-embedded (FFPE) breast cancer tissue samples from the patients treated over two years at the Yonsei University Severance Hospital, Republic of Korea.	Paraffin	115-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-57
25203299-6	2014	We developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes.	Paraffin	127-135	ETS variant transcription factor 1	Homo sapiens	88-92
25033726-5	2014	We studied the expression of WT-1 in formalin-fixed, paraffin-embedded tumor sections from 77 cases of endometrial serous carcinoma.	Paraffin	53-61	WT1 transcription factor	Homo sapiens	29-33
25337593-5	2014	L1CAM expression was evaluated by immunohistochemistry using fresh formalin-fixed paraffin-embedded tissue block of the patients.	Paraffin	82-90	L1 cell adhesion molecule	Homo sapiens	0-5
24504073-0	2014	A novel approach for HLA-A typing in formalin-fixed paraffin-embedded-derived DNA.	Paraffin	52-60	major histocompatibility complex, class I, A	Homo sapiens	21-26
24504073-6	2014	In this study, we amplified the most polymorphic exons of the HLA-A gene, exons 2, 3, and 4, in 16 formalin-fixed paraffin-embedded samples &gt;10 years old.	Paraffin	114-122	major histocompatibility complex, class I, A	Homo sapiens	62-67
24867097-4	2014	Additionally, the protein expression of GOLPH3 was detected in 167 paraffin-embedded HCC samples by immunohistochemistry.	Paraffin	67-75	golgi phosphoprotein 3	Homo sapiens	40-46
24112103-3	2014	METHODS: TP53 mutations were determined with direct sequencing on paraffin-embedded carcinoma tissue from 31 young patients and compared with two older age OSCC reference groups: one from the same institute (N = 87) and an independent one (N = 675).	Paraffin	66-74	tumor protein p53	Homo sapiens	9-13
24878108-0	2014	Different detectability of cyclooxygenase-2 (COX-2) protein in standard paraffin sections and tissue microarrays of human melanomas and naevi - comparative study.	Paraffin	72-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	27-43
24878108-0	2014	Different detectability of cyclooxygenase-2 (COX-2) protein in standard paraffin sections and tissue microarrays of human melanomas and naevi - comparative study.	Paraffin	72-80	prostaglandin-endoperoxide synthase 2	Homo sapiens	45-50
24249219-0	2014	Progesterone receptor isoform analysis by quantitative real-time polymerase chain reaction in formalin-fixed, paraffin-embedded canine mammary dysplasias and tumors.	Paraffin	110-118	progesterone receptor	Canis lupus familiaris	0-21
24249219-10	2014	Analysis of progesterone receptor mRNA isoforms by RT-qPCR was successful in routinely formalin-fixed, paraffin-embedded tissue samples and enabled the distribution of isoforms A and B to be identified for the first time in dysplasias, benign tumors, and malignant tumors of the canine mammary gland.	Paraffin	103-111	progesterone receptor	Canis lupus familiaris	12-33
25159221-0	2014	Protease-resistant SOD1 aggregates in amyotrophic lateral sclerosis demonstrated by paraffin-embedded tissue (PET) blot.	Paraffin	84-92	superoxide dismutase 1	Homo sapiens	19-23
24946721-3	2014	Expression of TGFbeta-1 and EHD1 was evaluated by immunohistochemistry in paraffin sections from 105 NSCLC patients.	Paraffin	74-82	transforming growth factor beta 1	Homo sapiens	14-23
24946721-3	2014	Expression of TGFbeta-1 and EHD1 was evaluated by immunohistochemistry in paraffin sections from 105 NSCLC patients.	Paraffin	74-82	EH domain containing 1	Homo sapiens	28-32
25273481-7	2014	The IAPP gene was extracted from the paraffin-embedded liver tissue and sequenced.	Paraffin	37-45	islet amyloid polypeptide	Ursus maritimus	4-8
25159221-5	2014	RESULTS: Mouse and human paraffin-embedded brain and spinal cord tissue can be blotted to membranes and stained with anti-SOD1 antibodies.	Paraffin	25-33	superoxide dismutase 1	Homo sapiens	122-126
25120063-4	2014	METHODS: Immunohistochemistry (IHC) was used to detect ARID3B expression in 63 formalin-fixed paraffin-embedded (FFPE) invasive breast cancer samples.	Paraffin	94-102	AT-rich interaction domain 3B	Homo sapiens	55-61
25337253-3	2014	Immunohistochemistry was performed to examine Wnt5A expression in 94 paraffin-embedded cervical cancer samples.	Paraffin	69-77	Wnt family member 5A	Homo sapiens	46-51
24937674-4	2014	We performed immunohistochemistry on paraffin-embedded tissue microarrays of active Src and several proteins involved in the PI3K/Akt/mTOR pathway, PIK3CA mutational analysis and in vitro studies (SKBR3 and BT474 cancer cells).	Paraffin	37-45	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	84-87
25104140-4	2014	Immunohistochemistry was used to analyze the expression levels of GOLPH3 protein in paraffin-embedded tissues from 109 cases of PDAC.	Paraffin	84-92	golgi phosphoprotein 3	Homo sapiens	66-72
23719484-5	2014	E-cadherin expression was evaluated by immunohistochemistry of formalin-fixed paraffin-embedded skin biopsies of foreign body granulomas (n = 21) and sarcoidosis (n = 21).	Paraffin	78-86	cadherin 1	Mus musculus	0-10
25076295-4	2014	DESIGN: Napsin A immunohistochemistry was performed using a rabbit polyclonal antibody on formalin-fixed, paraffin-embedded surgical and fine-needle aspiration biopsy-derived, paraffin-embedded cell block specimens.	Paraffin	106-114	napsin A aspartic peptidase	Homo sapiens	8-16
25076295-4	2014	DESIGN: Napsin A immunohistochemistry was performed using a rabbit polyclonal antibody on formalin-fixed, paraffin-embedded surgical and fine-needle aspiration biopsy-derived, paraffin-embedded cell block specimens.	Paraffin	176-184	napsin A aspartic peptidase	Homo sapiens	8-16
24989027-5	2014	Immunohistochemistry was then used to examine AEG-1 expression in paraffin-embedded tissues obtained from 105 patients, and its association with clinicopathological parameters including cancer classification was examined.	Paraffin	66-74	metadherin	Homo sapiens	46-51
25009592-4	2014	Paraffin immunohistochemistry revealed: an exclusively cytoplasmic granular expression of ALK; CD138, immunoglobulin A (IgA) and CD79alpha positivity; and focal expression of multiple myeloma oncogene 1 (Mum-1), CD30 and epithelial membrane antigen (EMA).	Paraffin	0-8	CD79a molecule	Homo sapiens	102-124
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Paraffin	160-168	interleukin 6	Homo sapiens	105-109
24374727-4	2014	We used a multiplex protein assay to determine the tumor expression levels of the proangiogenic proteins IL-6, IL-8, bFGF, PDGF-BB and VEGF-A in formalin-fixed paraffin-embedded tumors from the MAX clinical trial patients with available tissue samples.	Paraffin	160-168	C-X-C motif chemokine ligand 8	Homo sapiens	111-115
24788590-4	2014	EGFR/p53 mutational analysis was performed on DNA extracted from paraffin-embedded tumors.	Paraffin	65-73	epidermal growth factor receptor	Homo sapiens	0-4
25197376-7	2014	Immunohistochemical analysis showed that 128 of 172 (74.4%) paraffin-embedded archival astrocytomas samples exhibited positive AEG-1 expression.	Paraffin	60-68	metadherin	Homo sapiens	127-132
25494138-4	2014	Aim: In this research work, the over expression of EGFR in formalin fixed paraffin-embedded (FFPE) colorectal cancer tumor tissue of patients was studied.	Paraffin	74-82	epidermal growth factor receptor	Homo sapiens	51-55
24673429-4	2014	Ro52 expression was assessed by immunohistochemical staining of paraffin-embedded and frozen salivary gland biopsies from 28 pSS patients and 19 non-pSS controls from Swedish and Norwegian registries, using anti-human Ro52 monoclonal antibodies.	Paraffin	64-72	tripartite motif containing 21	Homo sapiens	0-4
25071276-8	2014	S-100 immunostaining was done on paraffin sections.	Paraffin	33-41	S100 calcium binding protein A1	Homo sapiens	0-5
24877885-5	2014	Meanwhile, we performed reverse transcription-polymerase chain reaction (RT-PCR) to measure the expression of six microRNAs targeting ET-1 in formalin-fixed, paraffin-embedded coronary arteries.	Paraffin	158-166	endothelin 1	Homo sapiens	134-138
24912939-4	2014	METHODS: The localization of the NQO1 protein was determined in the SiHa cervical squamous cancer cell line using immunofluorescence (IF) staining, and immunohistochemical (IHC) staining performed on paraffin-embedded cervical SCC specimens from 177 patients.	Paraffin	200-208	NAD(P)H quinone dehydrogenase 1	Homo sapiens	33-37
24861922-6	2014	We also evaluated the expression of MMP-9 and HPSE protein in paraffin-embedded tumor tissues by immunohistochemistry.	Paraffin	62-70	heparanase	Homo sapiens	46-50
25045435-3	2014	METHODS: EpCAM expression was assessed by immunohistochemistry on paraffin-embedded primary EOC-tissue samples.	Paraffin	66-74	epithelial cell adhesion molecule	Homo sapiens	9-14
24461457-0	2014	72-gene classifier for predicting prognosis of estrogen receptor-positive and node-negative breast cancer patients using formalin-fixed, paraffin-embedded tumor tissues.	Paraffin	137-145	estrogen receptor 1	Homo sapiens	47-64
24939299-1	2014	In order to investigate the expression of nerve growth factor (NGF) and hypoxia inducible factor-1alpha (HIF-1alpha) and its correlation with angiogenesis in non-small cell lung cancer (NSCLC), paraffin-embedded tissue blocks from 20 patients with NSCLC were examined.	Paraffin	194-202	nerve growth factor	Homo sapiens	42-61
24939299-1	2014	In order to investigate the expression of nerve growth factor (NGF) and hypoxia inducible factor-1alpha (HIF-1alpha) and its correlation with angiogenesis in non-small cell lung cancer (NSCLC), paraffin-embedded tissue blocks from 20 patients with NSCLC were examined.	Paraffin	194-202	nerve growth factor	Homo sapiens	63-66
24939299-1	2014	In order to investigate the expression of nerve growth factor (NGF) and hypoxia inducible factor-1alpha (HIF-1alpha) and its correlation with angiogenesis in non-small cell lung cancer (NSCLC), paraffin-embedded tissue blocks from 20 patients with NSCLC were examined.	Paraffin	194-202	hypoxia inducible factor 1 subunit alpha	Homo sapiens	105-115
24287458-7	2014	Among them, quantitative RT-PCR using frozen and paraffin-embedded materials demonstrated that expression levels of miR193a-5p (P=0.002), which has been suggested to downregulate SMARCB1 mRNA expression, showed statistically different expression levels between malignant rhabdoid tumor and epithelioid sarcoma with no SMARCB1 gene alterations.	Paraffin	49-57	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 1	Homo sapiens	179-186
25013419-4	2014	METHODS: CD99 expression was measured in paraffin samples of bone marrow and extramedullary biopsies of 170 patients with MM.	Paraffin	41-49	CD99 molecule (Xg blood group)	Homo sapiens	9-13
24700253-4	2014	The expression of Notch1 was examined in paraffin-embedded sections of ICC (n=44) by immunohistochemistry.	Paraffin	41-49	notch receptor 1	Homo sapiens	18-24
25031739-4	2014	Wnt-5a and beta-catenin protein expression was detected by immunohistochemical staining of paraffin-embedded tissues of 85 cases of HCC and corresponding para-carcinoma tissues and 15 cases of hepatic cirrhosis.	Paraffin	91-99	Wnt family member 5A	Homo sapiens	0-6
24417340-6	2014	BRAF(V600E) testing was performed on paraffin-embedded blocks using SNaPshot mutational analysis.	Paraffin	37-45	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-5
25141312-5	2014	MATERIALS AND METHODS: An immunohistochemistry study of IMP3 oncofetal protein was performed on paraffin-embedded blocks of 76 cases, including Barrett"s esophagus, esophageal squamous epithelium, Barrett"s esophagus with low-grade dysplasia, Barrett"s esophagus with high-grade dysplasia, moderately differentiated esophageal adenocarcinoma, and poorly differentiated esophageal adenocarcinoma.	Paraffin	96-104	IMP U3 small nucleolar ribonucleoprotein 3	Homo sapiens	56-60
22891713-3	2014	The c.1430G&gt;T mutation in c-KIT exon 9 was detected in 15.7% (11 of 70) of samples by mutant-specific PCR but in only 7.1% (5 of 70) by PCR-restriction fragment length polymorphism (RFLP) in the genomic DNA isolated from 70 formalin-fixed paraffin-embedded sections or cells collected by fine needle aspiration.	Paraffin	242-250	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	29-34
24883046-0	2014	Assessment of vascular endothelial growth factor in formalin fixed, paraffin embedded colon cancer specimens by means of a well-based reverse phase protein array.	Paraffin	68-76	vascular endothelial growth factor A	Homo sapiens	14-48
24883046-6	2014	Protein lysates derived from formalin fixed, paraffin embedded tissue contained measurable immunoreactive VEGF molecules.	Paraffin	45-53	vascular endothelial growth factor A	Homo sapiens	106-110
24368645-5	2014	Mutational analysis of p53 and EGFR was performed on DNA extracted from paraffin-embedded tumors.	Paraffin	72-80	tumor protein p53	Homo sapiens	23-26
24215154-6	2014	RESULTS: Positive immunohistochemical staining for HCA2 was found in paraffin sections of human retina, and positive immunocytochemical staining for HCA2 in primary human RPE cells.	Paraffin	69-77	hydroxycarboxylic acid receptor 2	Homo sapiens	51-55
24679073-6	2014	RESULTS: We report that LDH-A was overexpressed in 52 of 54 (96%) paraffin-embedded cancer tissue samples and 0 of 54 para-carcinoma tissue samples.	Paraffin	66-74	lactate dehydrogenase A	Homo sapiens	24-29
24464231-5	2014	Here we describe a newly developed monoclonal antibody binding to the C-terminus of neurofibromin (clone NFC) which was selected for optimal performance in routinely processed formalin-fixed and paraffin-embedded tissue.	Paraffin	195-203	neurofibromin 1	Homo sapiens	84-97
24594115-6	2014	MATERIALS AND METHODS: Pyrosequencing and Sanger sequencing were performed to identify KRAS and BRAF mutations in paraffin-embedded samples of CRC.	Paraffin	114-122	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	96-100
24227542-3	2014	Immunohistochemistry for RECK protein was performed on formalin fixed and paraffin-embedded sections.	Paraffin	74-82	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	25-29
24421209-5	2014	Claudin-4 immunohistochemistry was performed on cell-block paraffin sections and scored for staining intensity, staining pattern (cytoplasmic versus membranous), and percentage of positive tumor cells.	Paraffin	59-67	claudin 4	Homo sapiens	0-9
24491355-4	2014	A combined analysis of immunohistochemistry and fluorescence in situ hybridization revealed ERBB2-amplified cancer cells in 51 of 475 formalin-fixed, paraffin-embedded gastric adenocarcinomas.	Paraffin	150-158	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-97
24119914-4	2014	MATERIALS AND METHODS: Immunohistochemistry was performed to examine AEG-1 protein expression in paraffin-embedded tissues from 38 FHWT patients.	Paraffin	97-105	metadherin	Homo sapiens	69-74
24290802-4	2014	METHODS: Immunohistochemical staining for adipophilin was performed on paraffin-embedded tissues and correlated with hematoxylin-eosin, periodic acid-Schiff (PAS), and mucicarmine-stained preparations.	Paraffin	71-79	perilipin 2	Homo sapiens	42-53
25911848-7	2014	We analyzed exon 15 of the BRAF gene in isolated DNA from 80 Formalin Fixed Paraffin-embedded (FFPE) CRC tumor tissues using PCR-RFLP method.	Paraffin	76-84	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	27-31
24581082-5	2014	XB130 expression was detected by immunohistochemical analysis on the paraffin-embedded tumour sections.	Paraffin	69-77	actin filament associated protein 1 like 2	Homo sapiens	0-5
24529991-5	2014	We show that DBs specifically detect the activated HER2/HER3 complex in formalin-fixed, paraffin-embedded cancer cells and exhibit superior detection specificity for phospho-HER3 compared to the corresponding monoclonal antibody.	Paraffin	88-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-55
23808402-4	2014	The BRAF assay was fully characterized by using plasmids and genomic DNA extracted from cell lines, metastatic colorectal cancer formalin-fixed, paraffin-embedded (FFPE) tissues, and thyroid nodule fine-needle aspirates.	Paraffin	145-153	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	4-8
24399291-3	2014	Immunohistochemistry was adopted to detect the expression of mGluRs (mGluR1, mGluR5, mGluR4) in 118 paraffin embedded osteosarcoma tissues and eight normal bone tissues.	Paraffin	100-108	glutamyl-tRNA synthetase 2, mitochondrial	Mus musculus	61-67
24461304-3	2014	We report a 71-year-old man with pleural EHE harboring CAMTA1 rearrangement confirmed by fluorescence in situ hybridization on paraffin embedded tissue.	Paraffin	127-135	calmodulin binding transcription activator 1	Homo sapiens	55-61
24753761-4	2014	APOBEC3G expression was evaluated by immunohistochemistry in paraffin-embedded primary colon carcinoma and paired hepatic metastasis tissues from 136 patients with liver metastasis from colon carcinoma that underwent hepatic resection.	Paraffin	61-69	apolipoprotein B mRNA editing enzyme catalytic subunit 3G	Homo sapiens	0-8
24162004-1	2014	We describe a case of human Becker muscular dystrophy (BMD)-like myopathy that was characterized by the declined stainability of dystrophin at sarcolemma in a pig and the immunostaining for dystrophin on the formalin-fixed, paraffin-embedded (FFPE) tissue.	Paraffin	224-232	dystrophin	Sus scrofa	190-200
24563687-4	2014	To this end we optimised antibodies against the proline-hydroxylated forms of HIF-1alpha for use in formalin fixed paraffin embedded (FFPE) immunohistochemistry to assess effects in tumour cells in vivo.	Paraffin	115-123	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
24398760-2	2014	METHOD: The presence of VEGF and MMP-9 proteins in paraffin-embedded tumour specimens from patients with glioma was detected using immunohistochemistry.	Paraffin	51-59	vascular endothelial growth factor A	Homo sapiens	24-28
23845288-5	2014	MATERIAL AND METHODS: In this retrospective study, BRAF mutation status was examined by direct sequencing on paraffin-embedded tumour specimens from 46 patients undergoing surgery for PTC in our institution from 1985 to 2000.	Paraffin	109-117	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	51-55
23798470-3	2014	METHODS: We examined the expression of HIF-1alpha, vascular endothelial growth factor-A (VEGF-A), thymidine phosphorylase (TP) and basic fibroblast growth factor (bFGF) in a total of 100 paraffin-embedded PDAC primary tumors using immunohistochemical staining, and assessed their clinicopathological correlations.	Paraffin	187-195	fibroblast growth factor 2	Homo sapiens	163-167
24287180-4	2014	Immunohistochemistry staining was adopted to determine the expression of SIRT3 in 65 formalin-fixed, paraffin-embedded samples from GC patients.	Paraffin	101-109	sirtuin 3	Homo sapiens	73-78
24555932-8	2014	MAb 5A5 detects HPCAL1 in formalin-fixed, paraffin-embedded pancreatic cancer cell lines, making it a potentially useful reagent for pathologists.	Paraffin	42-50	hippocalcin-like 1	Mus musculus	16-22
24374892-3	2014	METHODS: The protein levels of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha were detected by immunohistochemistry on paraffin sections of 126 paired hepatocellular carcinoma tissue and peritumoral tissue samples.	Paraffin	140-148	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-62
24287180-8	2014	Furthermore, immunohistochemistry analysis of 65 formalin-fixed, paraffin-embedded samples from GC patients showed that 67.7% (44/65) had decreased SIRT3 staining in the cancer tissues.	Paraffin	65-73	sirtuin 3	Homo sapiens	148-153
24112633-10	2014	Adipophilin positivity in vesicular and granular forms was detected in paraffin sections in all invasive tumors, most prominently in moderately differentiated and well-differentiated lesions.	Paraffin	71-79	perilipin 2	Homo sapiens	0-11
23791475-6	2014	These findings show that WT1 is a reliable marker of human sympathetic neuroblasts, which can be used routinely in formalin-fixed, paraffin-embedded tissues.	Paraffin	131-139	WT1 transcription factor	Homo sapiens	25-28
24377577-0	2014	High resolution melting analysis for epidermal growth factor receptor mutations in formalin-fixed paraffin-embedded tissue and plasma free DNA from non-small cell lung cancer patients.	Paraffin	98-106	epidermal growth factor receptor	Homo sapiens	37-69
23702645-4	2014	METHODS: HER2 protein expression was investigated using a FDA-approved antibody in 87 formalin-fixed and paraffin-embedded cases of PDAC with complete follow-up.	Paraffin	105-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
25422191-8	2014	The detection of DcR3 protein in the formalin- fixed and paraffin-embedded samples could assist to predict in prognosis of BUC patients.	Paraffin	57-65	TNF receptor superfamily member 6b	Homo sapiens	17-21
24716981-4	2014	Expression of p53 protein was evaluated immunohistochemically in sections of paraffin- embedded tissue.	Paraffin	77-85	tumor protein p53	Homo sapiens	14-17
24528049-3	2014	MATERIALS AND METHODS: In this prospective study, EGFR mutations in exons 18, 19, 20 and 21 in formalin-fixed paraffin-embedded biopsy specimens of consecutive NSCLC patients were asessed by real-time polymerase chain reaction.	Paraffin	110-118	epidermal growth factor receptor	Homo sapiens	50-54
24877104-6	2014	DAPK protein expression was performed using immunohistochemical assays in formalin-fixed, paraffin-embedded sections.	Paraffin	90-98	death associated protein kinase 1	Homo sapiens	0-4
24761869-2	2014	METHODS: Immunohistochemistry was applied to detect the expression of ERCC1, MSH2 and PARP1 in 111 cases of non-small cell lung cancer paraffin embedded surgical specimens.	Paraffin	135-143	poly(ADP-ribose) polymerase 1	Homo sapiens	86-91
23073516-1	2014	BACKGROUND: Investigation of p53 immunoreactivity in formalin-fixed paraffin-embedded tissues of normal renal tissue and renal cell carcinoma with respect to histopathologic subtype and nuclear grade of RCC.	Paraffin	68-76	tumor protein p53	Homo sapiens	29-32
24890176-0	2014	A simple and efficient method of DNA extraction from formalin-fixed and paraffin-embedded tissues for screening EGFR gene mutation by gene sequencing.	Paraffin	72-80	epidermal growth factor receptor	Homo sapiens	112-116
25016705-2	2014	METHODS: The presence of the Bcl-2/IgH fusion gene was detected in BM samples and paraffin-embedded lymph node (LN) samples from 103 patients with DLBCLs using FISH.	Paraffin	82-90	BCL2 apoptosis regulator	Homo sapiens	29-34
25016705-4	2014	RESULTS: Bcl-2/IgH translocation in paraffin-embedded LN tissue sections was observed in 43 (41.7%) patients by FISH.	Paraffin	36-44	BCL2 apoptosis regulator	Homo sapiens	9-14
25431591-5	2014	Paraffin sections were stained with CD34 and VEGF.	Paraffin	0-8	CD34 molecule	Homo sapiens	36-40
24262879-2	2014	METHODS: We assessed PIK3CA mutational status in exon 9 and exon 20 hot spots by Sanger sequencing of DNA derived from formalin fixed paraffin embedded tissue of 57 grade 3 endometrioid, 26 serous, 11 clear cell and 5 dedifferentiated carcinomas.	Paraffin	134-142	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	21-27
24300539-1	2014	The aims of this study were to assess the overexpression of p16 in formalin-fixed paraffin-embedded cervical carcinoma tissue blocks and to determine its concordance with the human papillomavirus (HPV) status using the SPF10-LiPA25 polymerase chain reaction System and its correlation with the histologic type of invasive cervical cancer (ICC) and individual HPV genotypes.	Paraffin	82-90	cyclin dependent kinase inhibitor 2A	Homo sapiens	60-63
23659424-6	2014	TLR4 expression was investigated by immunohistochemistry on paraffin sections of the trigeminal ganglia (TG).	Paraffin	60-68	toll-like receptor 4	Rattus norvegicus	0-4
24252932-5	2014	We also evaluated BATF2 expression in 202 paraffin-embedded OTSCC and 30 adjacent non-tumor samples by immunohistochemistry, and its relationship with clinicopathological features and prognosis was investigated.	Paraffin	42-50	basic leucine zipper ATF-like transcription factor 2	Homo sapiens	18-23
24669077-9	2014	Paraffin sections were immunostained with TTF-1 and p-63 and the tumors were subtyped.	Paraffin	0-8	NK2 homeobox 1	Homo sapiens	42-47
24173110-4	2014	Three SNPs in the p53 pathway were identified using the Sanger sequencing method from retrospectively collected paraffin-embedded biopsy specimens.	Paraffin	112-120	tumor protein p53	Homo sapiens	18-21
24527533-2	2014	METHODS: We determined the expressions of Cx26, Cx32 and Cx43 in the paraffin samples from 31 cases of PCa and 23 cases of BPH by SABC immunohistochemical staining, and analyzed the relationship of their expressions with the clinical and pathological parameters of PCa and BPH using the semiquantitative method.	Paraffin	69-77	gap junction protein beta 2	Homo sapiens	42-46
25300614-3	2014	METHODS: We assessed VEGF mRNA amplification on paraffin-embedded specimens by applying the RNAscope method for the first time in human pterygium, an in situ hybridization-based technique able to detect VEGF mRNA as a single gene copy on paraffin-embedded samples.	Paraffin	48-56	vascular endothelial growth factor A	Homo sapiens	21-25
25300614-3	2014	METHODS: We assessed VEGF mRNA amplification on paraffin-embedded specimens by applying the RNAscope method for the first time in human pterygium, an in situ hybridization-based technique able to detect VEGF mRNA as a single gene copy on paraffin-embedded samples.	Paraffin	238-246	vascular endothelial growth factor A	Homo sapiens	21-25
24358187-6	2013	Single microRNA RT-qPCR was conducted on formalin-fixed paraffin-embedded tumor biopsies of 20 additional cases, confirming higher expression of miR-9-5p, miR-31-5p, miR-129-2-3p and miR-214-3p in PCFCL as compared to PCLBCL-LT. MicroRNAs previously described to be higher expressed in ABC-type as compared to GCB-type nodal DLBCL were not differentially expressed between PCFCL and PCLBCL-LT.	Paraffin	56-64	microRNA 95	Homo sapiens	145-153
24391788-5	2013	Among these miRNAs, miR-133a and miR-133b expression was decreased by 135 folds and 47 folds respectively and the decreased expression was confirmed in both frozen and paraffin-embedded osteosarcoma samples.	Paraffin	168-176	microRNA 133b	Homo sapiens	33-41
23892415-4	2013	We had evaluated the frequency of EGFR mutations with three highly sensitive PCR techniques in formalin-fixed, paraffin-embedded samples of 143 NSCLC patients with central nervous system (CNS) metastases.	Paraffin	111-119	epidermal growth factor receptor	Homo sapiens	34-38
24286402-5	2013	METHODS: We have therefore retrospectively examined expression of miR-30b miR-30c in 41 formalin fixed paraffin embedded tissue samples from NSCLC patients when TKIs were used as first line therapy.	Paraffin	103-111	microRNA 30b	Homo sapiens	66-73
23700252-3	2013	Paraffin-embedded full-thickness isthmic segment of oviduct specimens received immunohistochemistry with c-kit/CD117 antibody.	Paraffin	0-8	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	105-110
23700252-3	2013	Paraffin-embedded full-thickness isthmic segment of oviduct specimens received immunohistochemistry with c-kit/CD117 antibody.	Paraffin	0-8	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	111-116
24100522-0	2013	Reliable PCR quantitation of estrogen, progesterone and ERBB2 receptor mRNA from formalin-fixed, paraffin-embedded tissue is independent of prior macro-dissection.	Paraffin	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-61
23873108-2	2013	Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient"s formalin-fixed paraffin-embedded tissue blocks.	Paraffin	263-271	Bmi1 polycomb ring finger oncogene	Mus musculus	81-85
23643871-3	2013	METHODS: Galectin-7 expression was assessed by immunohistochemical staining of a tissue microarray of paraffin-embedded specimens from 161 patients with cervical SCC treated with definitive radiation therapy in 1980-1999.	Paraffin	102-110	galectin 7	Homo sapiens	9-19
24551639-3	2013	MATERIAL AND METHODS: We performed IHC detection of p16(INK4a) in sections of paraffin embedded formalin fixed tissues of leukoplakia with or without dysplasia (n= 21) and SCC lesions (n= 69) and correlated with various patterns of p16(INK4a) positivity with respect to histological diagnosis.	Paraffin	78-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	52-55
24551639-3	2013	MATERIAL AND METHODS: We performed IHC detection of p16(INK4a) in sections of paraffin embedded formalin fixed tissues of leukoplakia with or without dysplasia (n= 21) and SCC lesions (n= 69) and correlated with various patterns of p16(INK4a) positivity with respect to histological diagnosis.	Paraffin	78-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	56-61
23674382-12	2013	CONCLUSIONS: EC and EZH2 expression was determined reliably by IHC on paraffin sections of EUS-FNA cell block specimens.	Paraffin	70-78	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	20-24
23994645-4	2013	This assay is successfully applied to the simultaneous detection of ERG3p, ERG5p, PTEN, and CEN10 genes in formalin-fixed, paraffin-embedded prostate tissues on BenchMark ULTRA instruments.	Paraffin	123-131	ETS transcription factor ERG	Homo sapiens	68-73
24347769-8	2013	The most commonly prescribed PIM was mineral oil-liquid paraffin (30, 14.3%) followed by spironolactone (25, 11.9%), digoxin (19, 9%), and benzodiazepines (14, 6.7%).	Paraffin	56-64	Pim-1 proto-oncogene, serine/threonine kinase	Homo sapiens	29-32
24499539-4	2013	Therefore, in this study, we analysed the combination of the expression of the extracellular matrix components Fibronectin and SPARC on formalin-fixed paraffin embedded tissue derived from 173 patients with DLBCL in order to recapitulate gene expression profiling data.	Paraffin	151-159	fibronectin 1	Homo sapiens	111-122
23702732-4	2013	Utilizing the data set from our previously performed DNA microarray studies on formalin-fixed and paraffin-embedded tissue, we found that the genes C15orf48 and KRT9 had a distinct and robust gene expression pattern in distinguishing squamous cell carcinoma from pseudoepitheliomatous hyperplasia.	Paraffin	98-106	chromosome 15 open reading frame 48	Homo sapiens	148-156
24301760-2	2013	In this study, a BRAF V600E mutation was detected in formalin-fixed and paraffin-embedded PTC samples using multiplex allele-specific polymerase chain reaction and denaturing high-performance liquid chromatography.	Paraffin	72-80	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	17-21
24551813-4	2013	The over-expression of HER-2/neu was examined retrospectively by immunohistochemistry method in 60 paraffin embedded samples collected in Babol, Iran, between 2010 and 2011.	Paraffin	99-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-32
24079595-3	2013	To reveal the spatial and temporal expression of DGKtheta we performed immunohistochemical staining on paraffin sections of mouse embryos.	Paraffin	103-111	diacylglycerol kinase, theta	Mus musculus	49-57
24094966-10	2013	Immunohistochemical staining for calretinin using paraffin-embedded tissue sections after cryostat sections clearly demonstrated decreased staining intensity compared to MAP-2.	Paraffin	50-58	calbindin 2	Homo sapiens	33-43
24066029-3	2013	In this report, we used a multispectral quantum dot labeling technique to label six RANK and c-Met convergent signaling pathway mediators simultaneously in formalin fixed paraffin embedded (FFPE) tissue specimens, quantify the intensity of each expression at the sub-cellular level, and investigated their potential utility as predictors of patient survival in Caucasian-American, African-American and Chinese men.	Paraffin	171-179	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	93-98
24086281-7	2013	Here we report an assay based on a rabbit monoclonal antibody that can reliably detect endogenous LKB1 protein (and its absence) in mouse and human formalin-fixed, paraffin-embedded tissues.	Paraffin	164-172	serine/threonine kinase 11	Mus musculus	98-102
24327789-6	2013	We determined the whole nucleotide sequence of cox1 (1,608 bp) using the paraffin-embedded cystic tissue which was compared with E. multilocularis isolates from China, Japan, Kazakhstan, Austria, France, and Slovakia.	Paraffin	73-81	COX1	Echinococcus multilocularis	47-51
24433772-2	2013	METHODS: The expression of Gli1, MDM2 and p53 proteins in 57 paired paraffin embedded pancreatic ductal adenocarcinoma (PDAC) specimens and adjacent non-cancerous pancreatic tissues was detected by immunohistochemistry.	Paraffin	68-76	tumor protein p53	Homo sapiens	42-45
23933945-3	2013	Expression of HER-2 and NF-KB protein were detected by immunohistochemical staining (SP method) of paraffin-embedded tissues in 75 tumors (observed group) and 22 normal gastric specimens.	Paraffin	99-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-19
23410206-5	2013	METHODS: We examined immunohistochemical expression of the Hh signaling mediators Sonic Hedgehog (Shh) and Glioblastoma (Gli)2 in paraffin-embedded normal versus histologically characterized human MTC tissue.	Paraffin	130-138	GLI family zinc finger 2	Homo sapiens	121-126
23857189-4	2013	METHODS: Small glutamine-rich tetratricopeptide repeat-containing protein alpha expression was evaluated by Western blot in 8 paired fresh lung cancer tissues and immunohistochemistry on 83 paraffin-embedded sections.	Paraffin	190-198	small glutamine rich tetratricopeptide repeat co-chaperone alpha	Homo sapiens	9-79
24332055-4	2013	The expression of ERalpha and ERbeta was analyzed by immunohistochemistry on paraffin-embedded sections.	Paraffin	77-85	estrogen receptor 1	Homo sapiens	18-25
24009630-0	2013	Comparison of Three BRAF Mutation Tests in Formalin-Fixed Paraffin Embedded Clinical Samples.	Paraffin	58-66	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	20-24
23727348-0	2013	Detection of truncated HER2 forms in formalin-fixed, paraffin-embedded breast cancer tissue captures heterogeneity and is not affected by HER2-targeted therapy.	Paraffin	53-61	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-27
23959396-4	2013	Using the VeraTag  assay platform, we developed a dual antibody proximity-based assay for the precise quantitation of HER3 total protein (H3T) from formalin-fixed paraffin-embedded (FFPE) breast tumors.	Paraffin	163-171	H3.4 histone	Homo sapiens	118-141
23977449-4	2013	A novel in situ hybridization method (RNAscope) was used to determine the transcript level of two relatively low expressed genes, CD44 and EpCAM in both individual formalin-fixed paraffin-embedded (FFPE) tissue sections and in an ESCC tissue microarray (TMA).	Paraffin	179-187	epithelial cell adhesion molecule	Homo sapiens	139-144
24707321-6	2013	Reverse transcription-polymerase chain reaction using paraffin sections amplified a SYT-SSX1 chimera transcript.	Paraffin	54-62	SSX family member 1	Homo sapiens	88-92
23883275-14	2013	CONCLUSIONS: STA fragment analysis is a simple and sensitive method to detect BRAF V600 mutations in formalin-fixed paraffin-embedded clinical samples.	Paraffin	116-124	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	78-82
24246914-2	2013	METHODS: ER immunostaining (EnVision method) was performed in 160 type I EC and 39 type II EC paraffin samples and was scored by ASCO/CAP criterion, H-Score and Allred scoring system.	Paraffin	94-102	estrogen receptor 1	Homo sapiens	9-11
23909422-6	2013	In addition, M3H9 MAb can detect the expression of the MuD protein in formalin-fixed, paraffin-embedded mouse ovary and uterus tissues.	Paraffin	86-94	adaptor-related protein complex 5, mu 1 subunit	Mus musculus	55-58
23743605-5	2013	We investigated 37 cases with hypopharyngeal squamous cell carcinoma, determined REG mRNA expression, which is easily detected in formalin-fixed paraffin-embedded tissues using the real-time reverse transcriptase-polymerase chain reaction method, and evaluated the survival rate using the Kaplan-Meier method.	Paraffin	145-153	regenerating family member 1 alpha	Homo sapiens	81-84
22362219-2	2013	In this study, we aimed to analyze the expression levels of Ki67 (MKI67) messenger RNA (mRNA) derived from formalin-fixed paraffin-embedded (FFPE) tissues for comparison with the immunohistochemical Ki67 labeling index, and investigate the correlation coefficients with clinical outcomes.	Paraffin	122-130	marker of proliferation Ki-67	Homo sapiens	66-71
23830013-0	2013	A survey of TREM2 antibodies reveals neuronal but not microglial staining in formalin-fixed paraffin-embedded postmortem Alzheimer"s brain tissues.	Paraffin	92-100	triggering receptor expressed on myeloid cells 2	Homo sapiens	12-17
23358413-0	2013	Droplet digital PCR measurement of HER2 copy number alteration in formalin-fixed paraffin-embedded breast carcinoma tissue.	Paraffin	81-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-39
23660872-5	2013	miRNA expression profiles were validated in an independent series of 30 composed of VHL-, SDHB-, SDHD-, and RET-related formalin-fixed paraffin-embedded PCC/PGL samples using quantitative real-time PCR.	Paraffin	135-143	ret proto-oncogene	Rattus norvegicus	108-111
23269354-2	2013	METHODS: The expression of E-cadherin was analysed immunohistochemically in formalin-fixed, paraffin-embedded samples from 54 patients with advanced-stage serous ovarian cancer and related to clinicopathological characteristics and patients survival.	Paraffin	92-100	cadherin 1	Homo sapiens	27-37
23582793-4	2013	The expression of c-FLIP was analyzed using the standard imunohistochemical method on formalin-fixed and routinely processed paraffin-embedded lymph node specimens and evaluated semi quantitavely as a percentage of tumor cells.	Paraffin	125-133	CASP8 and FADD like apoptosis regulator	Homo sapiens	18-24
23842856-12	2013	Our study is the first CYP2D6 association study using DNA from paraffin-embedded tumor tissue in which potentially false interpretation of genotyping results because of LOH was excluded.	Paraffin	63-71	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	23-29
23670122-0	2013	Association between lymphoma prognosis and aberrant methylation of ID4 and ZO-1 in bone marrow and paraffin-embedded lymphoma tissues of treatment-naive patients.	Paraffin	99-107	inhibitor of DNA binding 4, HLH protein	Homo sapiens	67-70
23670122-1	2013	The aim of the present study was to investigate the association between lymphoma prognosis and aberrant methylation of inhibitor of DNA binding factor 4 (ID4) and tight junction protein 1 (ZO-1) genes in samples isolated from the bone marrow and paraffin-embedded lymphoma tissues of treatment-naive lymphoma patients.	Paraffin	246-254	inhibitor of DNA binding 4, HLH protein	Homo sapiens	154-157
23670122-1	2013	The aim of the present study was to investigate the association between lymphoma prognosis and aberrant methylation of inhibitor of DNA binding factor 4 (ID4) and tight junction protein 1 (ZO-1) genes in samples isolated from the bone marrow and paraffin-embedded lymphoma tissues of treatment-naive lymphoma patients.	Paraffin	246-254	tight junction protein 1	Homo sapiens	189-193
23670122-4	2013	ID4 and ZO-1 promoter regions in the control group were completely unmethylated, whereas the rates of methylation of ID4 and ZO-1 in paraffin-embedded lymphoma tissues of the lymphoma patients were 80.4 and 84.3%, respectively.	Paraffin	133-141	inhibitor of DNA binding 4, HLH protein	Homo sapiens	117-120
23670122-4	2013	ID4 and ZO-1 promoter regions in the control group were completely unmethylated, whereas the rates of methylation of ID4 and ZO-1 in paraffin-embedded lymphoma tissues of the lymphoma patients were 80.4 and 84.3%, respectively.	Paraffin	133-141	tight junction protein 1	Homo sapiens	125-129
23670122-6	2013	The methylation positivity rates of the ID4 and ZO-1 genes in the bone marrow and paraffin-embedded lymphoma tissues of non-Hodgkin lymphoma patients were significantly higher compared to the rates in the Hodgkin lymphoma patients.	Paraffin	82-90	inhibitor of DNA binding 4, HLH protein	Homo sapiens	40-43
23670122-6	2013	The methylation positivity rates of the ID4 and ZO-1 genes in the bone marrow and paraffin-embedded lymphoma tissues of non-Hodgkin lymphoma patients were significantly higher compared to the rates in the Hodgkin lymphoma patients.	Paraffin	82-90	tight junction protein 1	Homo sapiens	48-52
23694980-3	2013	METHODS: EpCAM expression was analyzed by immunohistochemistry using the avidin-biotin-complex method on paraffin-embedded OC tissues obtained at primary surgery as well as on corresponding tumor samples of the same patients at relapse.	Paraffin	105-113	epithelial cell adhesion molecule	Homo sapiens	9-14
23509317-7	2013	Immunohistochemical staining for HIF1/2alpha was performed on formalin-fixed, paraffin-embedded tumor tissue.	Paraffin	78-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	33-44
23663243-5	2013	The p53 codon 72 SNP was identified from retrospectively collected paraffin-embedded biopsy specimens using Sanger sequencing.	Paraffin	67-75	tumor protein p53	Homo sapiens	4-7
23635316-4	2013	METHODS: SBEM protein expression was detected in 87 available formalin-fixed paraffin-embedded (FFPE) tissue specimens from TNBC patients by means of immunohistochemistry (IHC).	Paraffin	77-85	mucin like 1	Homo sapiens	9-13
23386666-0	2013	Comparison of molecular testing methods for the detection of EGFR mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer.	Paraffin	94-102	epidermal growth factor receptor	Homo sapiens	61-65
23386666-1	2013	AIM: To conduct a methods correlation study of three different assays for the detection of mutations at EGFR gene in human formalin-fixed paraffin-embedded tumour (FFPET) specimens of non-small cell lung carcinomas (NSCLC).	Paraffin	138-146	epidermal growth factor receptor	Homo sapiens	104-108
23825889-5	2013	Immunohistochemistry for CD10 was performed on the sections obtained from formalin-fixed, paraffin-embedded blocks.	Paraffin	90-98	membrane metalloendopeptidase	Homo sapiens	25-29
23526420-5	2013	And immunohistochemistry was used to evaluate BAP1 expression in archived 252 paraffin-embedded CRC specimens.	Paraffin	78-86	BRCA1 associated protein 1	Homo sapiens	46-50
23594689-5	2013	The most common mutation, BRAF V600E, can be detected by DNA sequencing and immunohistochemistry on formalin fixed, paraffin embedded tumour tissue.	Paraffin	116-124	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	26-30
23392590-8	2013	The increased expression of IL-34 was confirmed by immunohistochemistry in paraffin-embedded salivary glands from p-SS patients.	Paraffin	75-83	interleukin 34	Homo sapiens	28-33
23675755-4	2013	METHODS AND RESULTS: Here, we analyzed expression of TTF-1 protein (clone SPT24) by immunohistochemical staining of sections from paraffin embedded tumor samples in 247 primary breast cancers from the population-based Norwegian Breast Cancer Screening Program.	Paraffin	130-138	NK2 homeobox 1	Homo sapiens	53-58
24648955-12	2013	P-selectin expression of the four groups of rat colon tissues was determined using immunohistochemistry on paraffin sections.	Paraffin	107-115	selectin P	Rattus norvegicus	0-10
23590575-0	2013	Detection of epidermal growth factor receptor mutations in formalin fixed paraffin embedded biopsies in Malaysian non-small cell lung cancer patients.	Paraffin	74-82	epidermal growth factor receptor	Homo sapiens	13-45
23589923-3	2013	Modified Movat"s pentachrome staining, HE staining, immunohistochemistry and transmission electron microscopy were used to observe and to identify serial paraffin sections of aortic foot and inflammatory cells in CA adventitia of apoE-/- mice of 60 weeks old.	Paraffin	154-162	apolipoprotein E	Mus musculus	230-234
23621958-0	2013	Analytic performance studies and clinical reproducibility of a real-time PCR assay for the detection of epidermal growth factor receptor gene mutations in formalin-fixed paraffin-embedded tissue specimens of non-small cell lung cancer.	Paraffin	170-178	epidermal growth factor receptor	Homo sapiens	104-136
23590575-3	2013	The aim of this study was to detect EGFR mutations in formalin fixed paraffin embedded (FFPE) samples using both Scorpion ARMS and high resolution melt (HRM) assay, and to compare the sensitivity of these methods.	Paraffin	69-77	epidermal growth factor receptor	Homo sapiens	36-40
23564797-3	2013	MATERIALS AND METHODS: The expression of GAL-7 was determined in 63 formalin-fixed, paraffin-embedded EOC tissues using an immunohistochemical method and we compared various associated clinicopathological factors.	Paraffin	84-92	galectin 7	Homo sapiens	41-46
23331771-8	2013	We highlight two major aspects of this case: (1) the unusual occurrence of early PTLD involving the cardiac allograft and causing a fatal outcome, (2) the application of an immunological technique for HLA-DRB1 typing to posttransplant paraffin-embedded autopsy material to identify the recipient origin of this early malignancy, thus excluding a possible donor-transmitted neoplasm.	Paraffin	235-243	major histocompatibility complex, class II, DR beta 1	Homo sapiens	201-209
23142337-3	2013	Immunohistochemistry (IHC) was performed to examine AEG-1 protein expression in paraffin-embedded tissues from 93 patients with TSCC.	Paraffin	80-88	metadherin	Homo sapiens	52-57
23108908-4	2013	ILK protein expression was analyzed in 102 archived, paraffin-embedded CRC samples using immunohistochemistry.	Paraffin	53-61	integrin linked kinase	Homo sapiens	0-3
23417164-6	2013	HER2 status was             determined by quantitative immunoassay of fresh-frozen tissue and by IHC/FISH             of corresponding paraffin-embedded tissue.	Paraffin	135-143	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
23084583-2	2013	In the present study, we evaluated HER2 mRNA expression using a new mRNA in situ detection technique called RNAscope in 211 cases of formalin-fixed, paraffin-embedded gastric carcinoma.	Paraffin	149-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-39
22218908-3	2013	METHODS: We used the polymer-based method to perform an immunohistochemistry analysis of c-Met expression on 59 formalin-fixed, paraffin-embedded sections of surgical specimens.	Paraffin	128-136	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	89-94
23798809-4	2013	Calretinin processing was done on the paraffin-embedded blocks after routine histopathological examination.	Paraffin	38-46	calbindin 2	Homo sapiens	0-10
23603344-5	2013	The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkB1, GADD45A and JNK1.	Paraffin	29-37	nuclear factor kappa B subunit 1	Homo sapiens	196-201
22820660-3	2013	METHODS: We immunohistochemically analyzed expression of V600E-mutant BRAF protein in archival formalin-fixed, paraffin-embedded tissue specimens of 142 epithelial ovarian tumors [98 invasive carcinomas and 44 tumors of low malignant potential (LMP)] using monoclonal antibody VE1.	Paraffin	111-119	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	70-74
23603344-5	2013	The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkB1, GADD45A and JNK1.	Paraffin	29-37	mitogen-activated protein kinase 8	Homo sapiens	215-219
22906243-8	2013	Immunohistochemical studies of paraffin-embedded BM biopsies from patients with myelofibrosis, and age-matched controls without fibrosis, indicated co-localization of SP and its receptor neurokinin-1 (NK1).	Paraffin	31-39	tachykinin precursor 1	Homo sapiens	167-169
23250572-2	2013	We scrutinized the brain for tricellulin expression in endothelial and neural cells by using real-time polymerase chain reaction, Western blot and immunohistochemical and immunocytochemical analysis of cultured brain cells and paraffin sections of brain.	Paraffin	227-235	MARVEL domain containing 2	Homo sapiens	29-40
23275449-0	2013	Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues.	Paraffin	160-168	pyruvate dehydrogenase phosphatase catalytic subunit 1	Homo sapiens	31-34
23769435-2	2013	METHODS: With Q-scoring assessment and ROC curve analysis,immunohistochemistry was used to screen a panel of 309 paraffin-embedded non-small cell lung cancer(NSCLC) tumor samples, of which EGFR gene mutational status was previously documented by PCR-DNA sequencing.	Paraffin	113-121	epidermal growth factor receptor	Homo sapiens	189-193
23769436-5	2013	CONCLUSION: With high sensitivity and good specificity, immunohistochemistry using EGFR mutation-specific monoclonal antibodies is an adequate, easy and cost-effective prescreening method to detect EGFR mutations using paraffin-embedded tissue specimens of lung adenocarcinomas.	Paraffin	219-227	epidermal growth factor receptor	Homo sapiens	83-87
23769436-5	2013	CONCLUSION: With high sensitivity and good specificity, immunohistochemistry using EGFR mutation-specific monoclonal antibodies is an adequate, easy and cost-effective prescreening method to detect EGFR mutations using paraffin-embedded tissue specimens of lung adenocarcinomas.	Paraffin	219-227	epidermal growth factor receptor	Homo sapiens	198-202
23391338-3	2013	METHODS: HER2 levels were centrally analyzed by immunohistochemistry (IHC), silver in situ hybridization (SISH) and qRT-PCR in 217 pretherapeutic formalin-fixed, paraffin-embedded (FFPE) core biopsies.	Paraffin	162-170	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
23414519-2	2013	METHODOLOGY: Immunohistochemical expression of COX2 and iNOS was assessed in formalin fixed paraffin wax processed tissues obtained from 155 patients with bladder cancers (87 SCC and 68 TCC) and 39 patients with benign bladder cystitis.	Paraffin	92-104	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-51
23414519-2	2013	METHODOLOGY: Immunohistochemical expression of COX2 and iNOS was assessed in formalin fixed paraffin wax processed tissues obtained from 155 patients with bladder cancers (87 SCC and 68 TCC) and 39 patients with benign bladder cystitis.	Paraffin	92-104	nitric oxide synthase 2	Homo sapiens	56-60
23483646-1	2013	BACKGROUND: The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR) mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) samples and to correlate EGFR mutational status as determined by each method with the clinical response to EGFR tyrosine kinase inhibitors (TKIs).	Paraffin	235-243	epidermal growth factor receptor	Homo sapiens	167-199
23483646-1	2013	BACKGROUND: The aims of this study were to evaluate the abilities of direct sequencing (DS), peptide nucleic acid (PNA) clamping, and pyrosequencing methods to detect epidermal growth factor receptor (EGFR) mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung carcinoma (NSCLC) samples and to correlate EGFR mutational status as determined by each method with the clinical response to EGFR tyrosine kinase inhibitors (TKIs).	Paraffin	235-243	epidermal growth factor receptor	Homo sapiens	201-205
24252159-4	2013	RESULTS: To detect BRAF V600E mutation in formalin-fixed, paraffin-embedded (FFPE) tissue, we developed a method using Amplification Refractory Mutation System (ARMS)-PCR.	Paraffin	58-66	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	19-23
22989055-6	2013	CFTR protein expression was studied by immunohistochemistry in paraffin sections of testicular biopsies of six infertile men: Sertoli cell only syndrome, maturation arrest, secondary obstructive azoospermia, primary obstructive azoospermia due to congenital bilateral absence of the vas deferens (CBAVD), severe oligozoospermia, and retrograde ejaculation.	Paraffin	63-71	CF transmembrane conductance regulator	Homo sapiens	0-4
23205744-3	2013	MATERIAL AND METHODS: TIMP-1 expression was evaluated by immunohistochemistry (IHC) on formalin fixed paraffin embedded primary tumor tissue in two independent cohorts comprised of 236 and 192 patients, respectively.	Paraffin	102-110	TIMP metallopeptidase inhibitor 1	Homo sapiens	22-28
23886169-2	2013	MATERIALS AND METHODS: EGFR gene exons 18-21 in 48 specimens of paraffin-embedded tumor tissue from NSCLC patients were amplified by PCR, followed by direct sequencing and analysis of links to clinicopathological features and prognosis.	Paraffin	64-72	epidermal growth factor receptor	Homo sapiens	23-27
23803047-2	2013	METHODS: The Scorpions amplification refractory mutation system (Scorpions ARMS) was used to measure mutations in exons 18, 19, 20 and 21 of the EGFR gene in paraffin-embedded tumor tissue from NSCLC cases, and statistical analysis was performed to investigate links with clinicopathological features in different histological types of NSCLC.	Paraffin	158-166	epidermal growth factor receptor	Homo sapiens	145-149
24501865-7	2013	Immunohistochemical evaluation of the S100A1 protein expression was carried out on representative archival formalin -fixed -paraffin-embedded tissue materials.	Paraffin	124-132	S100 calcium binding protein A1	Homo sapiens	38-44
23534715-3	2013	We therefore determined immunohistochemical (IHC) expression of c-KIT in paraffin sections from 120 radical cystectomies of SCCs originally obtained from the Pathology Department of Suez Canal University (Ismailia, Egypt).	Paraffin	73-81	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	64-69
24070170-3	2013	METHODS: We evaluated the association between semi-quantitative, immunohistochemical staining of ER in formalin-fixed paraffin-embedded breast carcinomas and breast cancer-specific mortality risk in an observational cohort of invasive breast cancer in 681 white women and 523 black women ages 35-64 years at first diagnosis of invasive breast cancer, who were followed for a median of 10 years.	Paraffin	118-126	estrogen receptor 1	Homo sapiens	97-99
23691506-8	2013	EGFR mutation analysis using formalin-fixed paraffin-embedded lung cancer tissues demonstrated a mutant peak with Method A, whereas the mutant peak was undetectable with Methods B or C. Method A yielded the best DNA quantity and quality with outstanding efficiency, particularly when paucicellular specimens were used.	Paraffin	44-52	epidermal growth factor receptor	Homo sapiens	0-4
24133909-9	2013	MVD was calculated by immunohistochemical staining of endothelial cells with CD34 on tumor tissue paraffin sections.	Paraffin	98-106	CD34 molecule	Homo sapiens	77-81
23625175-5	2013	Expression of M2-PK and VEGF were examined in 142 cases of paraffin-embedded tissue blocks from patients with advanced gastric cancer.	Paraffin	59-67	vascular endothelial growth factor A	Homo sapiens	14-28
21681971-10	2013	The presence of prominent INCI (P = 0.036), papillary fragments (P = 0.041), and histologic features of BAC on paraffin block (P = 0.039) correlated with the presence of EGFR mutations.	Paraffin	111-119	epidermal growth factor receptor	Homo sapiens	170-174
23967554-2	2013	This study investigated the difference of nestin expression between pre-cancer (carcinoma in situ - CIS) and cancer of cervix in 129 tissues (49 normal cervix, 41 CIS, and 39 invasive cervical cancer) through the use of a paraffin-embedded tissue array.	Paraffin	222-230	nestin	Homo sapiens	42-48
22939115-3	2013	Bag-1 protein expression was studied by immunohistochemistry on original paraffin embedded tissue from 217 patients with microscopic radical resection (R0) of adenocarcinoma of the pancreatic head or periampullary region.	Paraffin	73-81	BAG cochaperone 1	Homo sapiens	0-5
23838566-6	2013	Using immunocytochemistry (ICC) in human paraffin-embedded tissue, 12/15-LOX expression was seen in macrophages of the focally necrotic lesions in the periventricular white matter, as well as in glial cells throughout the surrounding white matter with reactive gliosis.	Paraffin	41-49	arachidonate 15-lipoxygenase	Homo sapiens	67-76
24020139-6	2013	Immunohistochemical investigation of Bcl-2 and KJ67 expression was undertaken on paraffin blocks and showed elevated expression in the cases with endometrial polyps and hyperplasia, in contrast to atrophic endometria.	Paraffin	81-89	BCL2 apoptosis regulator	Homo sapiens	37-42
23036330-8	2013	Here we present a study which investigates whether ddPCR can be used to assess HER2 transcript levels in formalin-fixed paraffin embedded (FFPE) human breast tumors and whether these ddPCR measurements agree with prior assessments of these same samples by pathologists using immunohistochemistry (IHC) and in some cases fluorescence in situ hybridization (FISH).	Paraffin	120-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
23613408-5	2013	Immunohistochemistry (IHC) was used to detect the expression of Twist1 protein in 40 paraffin embedded BUC specimens and 14 paired non-cancerous mucosas, and their relationships with clinicopathological features.	Paraffin	85-93	twist family bHLH transcription factor 1	Homo sapiens	64-70
23841222-0	2013	Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging.	Paraffin	97-105	epidermal growth factor receptor	Homo sapiens	17-49
22987628-4	2013	EPCAM protein was visualized by immunohistochemistry of selected corresponding paraffin embedded tumor tissues.	Paraffin	79-87	epithelial cell adhesion molecule	Homo sapiens	0-5
23159593-0	2013	Evaluation of BRAF mutation testing methodologies in formalin-fixed, paraffin-embedded cutaneous melanomas.	Paraffin	69-77	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	14-18
24222856-0	2013	Identification of DLEC1 D215N Somatic Mutation in Formalin Fixed Paraffin Embedded Melanoma and Melanocytic Nevi Specimens.	Paraffin	65-73	DLEC1 cilia and flagella associated protein	Homo sapiens	18-23
23344868-2	2013	MATERIAL AND METHODS: The ErbB2 and beta-catenin immunostaining was     performed on paraffin embedded tissue sections of 20 ACP using     avidin-biotin-peroxidase complex method.	Paraffin	85-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-31
23666690-0	2013	c-kit mutational analysis in paraffin material.	Paraffin	29-37	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
23555633-4	2013	We identified 5 different BRAF mutations in a single assay analyzing 75 different formalin-fixed paraffin-embedded (FFPE) samples of cutaneous melanoma metastases from 29 patients.	Paraffin	97-105	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	26-30
23460885-8	2013	Here we report a newly developed EpCAM RNA aptamer, also known as a chemical antibody, which is not only specific but also more sensitive than current antibodies for the detection of EpCAM in formalin-fixed paraffin-embedded primary breast cancers.	Paraffin	207-215	epithelial cell adhesion molecule	Homo sapiens	33-38
23460885-8	2013	Here we report a newly developed EpCAM RNA aptamer, also known as a chemical antibody, which is not only specific but also more sensitive than current antibodies for the detection of EpCAM in formalin-fixed paraffin-embedded primary breast cancers.	Paraffin	207-215	epithelial cell adhesion molecule	Homo sapiens	183-188
23584600-0	2013	A multisite blinded study for the detection of BRAF mutations in formalin-fixed, paraffin-embedded malignant melanoma.	Paraffin	81-89	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	47-51
23161722-3	2012	We designed a BRAF pyrosequencing assay specific for the V600E mutation, which has a sensitivity of 5% and is applicable to paraffin-embedded tissue.	Paraffin	124-132	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	14-18
23578430-2	2013	METHODS: The expression of CRT protein in 33 paired paraffin embedded PDAC specimens and adjacent non-cancerous pancreatic tissues were detected by immunohistochemistry.	Paraffin	52-60	calreticulin	Homo sapiens	27-30
23648296-9	2013	CONCLUSIONS: The success rate of ADx-EGFR real-time PCR for formalin-fixed and paraffin-embedded tissues samples is significantly higher than that of Sanger sequencing (P &lt; 0.01).	Paraffin	79-87	epidermal growth factor receptor	Homo sapiens	37-41
23030524-0	2012	Assessing HER2 amplification by IHC, FISH, and real-time polymerase chain reaction analysis (real-time PCR) following LCM in formalin-fixed paraffin embedded tissue from 40 women with ovarian cancer.	Paraffin	140-148	erb-b2 receptor tyrosine kinase 2	Homo sapiens	10-14
23154548-5	2012	fluorescence in situ hybridization was performed for FGFR1 on formalin-fixed paraffin-embedded tumor tissue.	Paraffin	77-85	fibroblast growth factor receptor 1	Homo sapiens	53-58
23181982-5	2012	We retrospectively analyzed EGFR gene copy number by fluorescence in situ hybridization (FISH) in paraffin-embedded tissue from 215 patients recruited through a prospective colorectal cancer screening procedure and undergoing surgical colectomy.	Paraffin	98-106	epidermal growth factor receptor	Homo sapiens	28-32
23055340-5	2012	METHODS: EGFR protein expression was studied in 98 paraffin embedded tissue samples, organized in a tissue microarray.	Paraffin	51-59	epidermal growth factor receptor	Homo sapiens	9-13
23153332-3	2012	METHODS: EGFR status was analyzed by immunohistochemistry (IHC) in paraffin-embedded samples from 357 patients who received chemotherapy in 4 first-line trials.	Paraffin	67-75	epidermal growth factor receptor	Homo sapiens	9-13
22528516-3	2012	NDRG2 and CD24 expression in paraffin-embedded specimens gathered from 166 patients with lung adenocarcinoma was detected by immunohistochemical method.	Paraffin	29-37	CD24 molecule	Homo sapiens	10-14
23174497-10	2012	The Food and Drug Administration has approved the cobas BRAF V600 Mutation Test developed by Roche to analyze BRAF mutation status in formalin-fixed paraffin-embedded tumor samples.	Paraffin	149-157	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	56-60
23174497-10	2012	The Food and Drug Administration has approved the cobas BRAF V600 Mutation Test developed by Roche to analyze BRAF mutation status in formalin-fixed paraffin-embedded tumor samples.	Paraffin	149-157	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	110-114
23174497-13	2012	Some cross-reactivity with other variants of mutant BRAF was seen with the cobas V600 platform; however, this clinical test offers highly sensitive reproducible BRAF V600E mutation analysis in formalin-fixed paraffin-embedded tumor samples.	Paraffin	208-216	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	161-165
23205120-5	2012	Immunohistochemical staining was performed to detect the expression of mTOR and PTEN in paraffin-embedded gastric tissue sections obtained from 33 patients with gastric cancer and 30 normal controls.	Paraffin	88-96	mechanistic target of rapamycin kinase	Homo sapiens	71-75
23151048-4	2012	METHODS: Trop-2 protein expression was quantified using tissue microarrays consisting of formalin-fixed paraffin-embedded specimens from 118 patients who underwent surgical staging from 2001-9 by laparotomy for EEC.	Paraffin	104-112	tumor associated calcium signal transducer 2	Homo sapiens	9-15
23397769-4	2012	E-cadherin expression was determined by immunohistochemistry in paraffin- embedded tissue specimens from 80 patients.	Paraffin	64-72	cadherin 1	Homo sapiens	0-10
22849322-3	2012	Double immunohistochemical staining of CD20 and CD27 was carried out on paraffin-embedded SG tissue from 10 pSS patients to distinguish CD20(+)/CD27(+) memory B cells, and identify the CD20(+) glandular B cell zones (BCZ).	Paraffin	72-80	keratin 20	Homo sapiens	39-43
22332713-0	2012	Multisite analytic performance studies of a real-time polymerase chain reaction assay for the detection of BRAF V600E mutations in formalin-fixed, paraffin-embedded tissue specimens of malignant melanoma.	Paraffin	147-155	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	107-111
22406363-10	2012	Mutation analysis of EGFR exons 19 and 21 is feasible in microdissected paraffin sections from archival tissues.	Paraffin	72-80	epidermal growth factor receptor	Homo sapiens	21-25
22923193-5	2012	EGFR mutations of 126 Formalin-Fixed Paraffin-Embedded (FFPE), 47 fresh frozen             tissues and from 47 matched pre-operation serum specimens of NSCLC patients were             screened by the HRM assays.	Paraffin	37-45	epidermal growth factor receptor	Homo sapiens	0-4
22905766-4	2012	Immunohistochemistry (IHC) was performed to examine GOLPH3 protein expression in paraffin-embedded tissues from 179 cN0 oral tongue cancer patients.	Paraffin	81-89	golgi phosphoprotein 3	Homo sapiens	52-58
21216575-5	2012	Paraffin sections of the kidneys from normal male Wistar rats were immunostained by anti-Bcl-2 monoclonal antibody.	Paraffin	0-8	BCL2, apoptosis regulator	Rattus norvegicus	89-94
23168703-6	2012	Mutational analysis of TP53 was done in DNA extracted from formalin fixed paraffin embedded tissue of 80 CaP and 24 BPH cases.	Paraffin	74-82	tumor protein p53	Homo sapiens	23-27
22879539-5	2012	Detection of BRAF(V600) mutations was performed by pyrosequencing of DNA extracted from paraffin embedded samples.	Paraffin	88-96	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	13-22
27847452-2	2012	The toxicant CCl4 was used to induce nephrotoxicity at a dose of 1 ml/kg as 1:1(v/v) mixture with liquid paraffin twice weekly for 8 weeks.	Paraffin	105-113	C-C motif chemokine ligand 4	Rattus norvegicus	13-17
22823995-8	2012	BRAF(V600E) mutation was identified in DNA from paraffin-embedded tissues by direct sequencing.	Paraffin	48-56	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-5
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Paraffin	97-105	basic leucine zipper ATF-like transcription factor 3	Homo sapiens	158-163
22675169-4	2012	GOLPH3 protein expression was analyzed in 258 archived, paraffin-embedded breast cancer samples using immunohistochemistry.	Paraffin	56-64	golgi phosphoprotein 3	Homo sapiens	0-6
22804458-3	2012	In the work, the CDKL1 mRNA level in fresh biopsy tissues from 186 breast cancer patients, with 98 benign tissues as negative control, and CDKL1 protein in 30 paraffin-embedded tissues from primary breast cancer patients were detected by the real-time reverse transcriptase-polymerase chain reaction (RT-PCR) assay and immunohistochemical staining, respectively.	Paraffin	159-167	cyclin dependent kinase like 1	Homo sapiens	139-144
22684875-8	2012	We also observed higher BCL2 mRNA expression in 19 of 20 KCOT frozen samples and moderate to high Bcl-2 immunopositivity in the basal layer cells of 16 of 18 paraffin embedded KCOTs (median: 42.6 %).	Paraffin	158-166	BCL2 apoptosis regulator	Homo sapiens	98-103
22430898-3	2012	Proximity ligation assays (PLAs) were used to determine quantitative expression levels of isoform-specific activation (phosphorylation) of Akt1 and Akt2 in formalin-fixed, paraffin-embedded cell lines and breast cancer tumour tissues in situ.	Paraffin	172-180	AKT serine/threonine kinase 1	Homo sapiens	139-143
22245114-3	2012	We collected 48 cases of fibrous dysplasia from 3 institutions from 2002 to 2011 and performed polymerase chain reaction and direct bidirectional sequencing of exons 8 and 9 of GNAS using paraffin-embedded tissues.	Paraffin	188-196	GNAS complex locus	Homo sapiens	177-181
22476621-5	2012	Immunohistochemistry on paraffin-embedded sections localized TFF3 protein and also TFF2 in AM cells and Western blot analysis revealed TFF3 protein in AM.	Paraffin	24-32	trefoil factor 3	Homo sapiens	61-65
21999410-0	2012	Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.	Paraffin	33-41	amyloid beta precursor protein	Homo sapiens	79-91
22417857-1	2012	The study of proto-oncogene Her-2/neu using the fluorescence in situ hybridization (FISH) technique in routinely paraffin-embedded formalin-fixed tissue has become commonplace over the past decade and mandatory among invasive breast cancer expressing a score 2+ by immunohistochemical analysis of c-erbB2 protein.	Paraffin	113-121	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-37
22417858-4	2012	HER2 expression was detected by immunohistochemistry (IHC) performed on formalin-fixed, paraffin-embedded sections of the corresponding tumors.	Paraffin	88-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
23135121-3	2012	METHODS: The expressions of VEGF-C antibodies and anti-podoplanin were detected in 21 normal oral tissues and 88 paraffin sections of OSCC by immunohistochemistry(S-P); Determination of LVD (assessed by immunostaining for podoplanin) was performed as suggested by Weidner, the numerical value expressed by x+-s Intratumoral lymphatic vessels (I-LVD) and peritumoral lymphatic vessels (P-LVD) were assessed, respectively.	Paraffin	113-121	vascular endothelial growth factor C	Homo sapiens	28-34
22839358-5	2012	METHODS: c-KIT expression was scored by immunohistochemistry (IHC) as positive or negative in 139 formalin-fixed paraffin-embedded (FFPE) cases of vulvar carcinomas arrayed in a tissue microarray (TMA) using the DAKO A4502 rabbit polyclonal c-KIT antibody (diluted 1:100).	Paraffin	113-121	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-14
22773565-0	2012	A comprehensive procedural approach to genotyping KRAS and BRAF from paraffin embedded tissues for diagnostic purposes.	Paraffin	69-77	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	59-63
22484287-7	2012	Immunohistochemical localization of neprilysin was performed in 30 paraffin embedded specimens.	Paraffin	67-75	membrane metalloendopeptidase	Homo sapiens	36-46
22813799-6	2012	METHODS: Paraffin sections were generated for H&amp;E, E-cadherin, or terminal deoxynucleotidyl transferase-mediated X-dUTP nick end labeling staining from Fgfr2IIIb-/- and wild-type embryos between embryonic days (E) 10.5 and E14.5.	Paraffin	9-17	cadherin 1	Mus musculus	55-65
23110010-2	2012	METHODS: We analyzed the frequency of BRAF mutation in patients with primary cutaneous melanoma (n=58) or non-cutaneous one (n=27) by performing dual priming oligonucleotide-based multiplex real-time polymerase chain reaction to isolate and to purify the DNA from the formalin-fixed and paraffin-embedded tumors.	Paraffin	287-295	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	38-42
21777924-2	2012	We report results of a pilot trial designed to determine if treatment-mediated changes in gene expression can be detected in formalin-fixed paraffin-embedded (FFPE) samples after 10-d exposure to anastrozole in estrogen receptor (ER)-positive breast cancer compared with untreated controls.	Paraffin	140-148	estrogen receptor 1	Homo sapiens	230-232
22421194-5	2012	In the retrospective cohort, the concordance of PIK3CA mutation status by BEAMing between formalin-fixed, paraffin-embedded (FFPE) samples and ctDNA from temporally matched plasma was 100% (34 of 34).	Paraffin	106-114	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	48-54
22837134-4	2012	METHODS: Immunohistochemical detection of nestin was carried out on tissue microarrays constructed from 114 formalin-fixed and paraffin-embedded NSCLC samples.	Paraffin	127-135	nestin	Homo sapiens	42-48
23360043-4	2012	Immunohistochemical staining for p53 was performed on formalin fixed paraffin embedded tissue sections with appropriate positive and negative control.	Paraffin	69-77	tumor protein p53	Homo sapiens	33-36
21519871-5	2012	Moreover, the expression of the LOXL2 protein in specimens from 83 paraffin-embedded blocks was examined by immunohistochemical staining.	Paraffin	67-75	lysyl oxidase like 2	Homo sapiens	32-37
22647525-0	2012	A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections.	Paraffin	197-205	erb-b2 receptor tyrosine kinase 2	Homo sapiens	67-71
22858706-5	2012	Paraffin-embebeded sections were immunostained for p53 and p21WAF1.	Paraffin	0-8	tumor protein p53	Homo sapiens	51-54
22643064-5	2012	AEG-1 protein expression was investigated by immunohistochemistry in paraffin-embedded materials from 74 distant normal mucosa, 107 adjacent mucosa, 158 primary tumour, 35 lymph node metastasis and 9 liver metastasis samples.	Paraffin	69-77	metadherin	Homo sapiens	0-5
22498947-0	2012	Genomic amplification of hTERC in paraffin-embedded tissues of cervical intraepithelial neoplasia and invasive cancer.	Paraffin	34-42	telomerase RNA component	Homo sapiens	25-30
22498947-7	2012	Therefore, hTERC amplification within cervical lesions can be accurately assessed by fluorescence in situ hybridization analysis on paraffin tissue microarrays.	Paraffin	132-140	telomerase RNA component	Homo sapiens	11-16
22647525-0	2012	A gene-protein assay for human epidermal growth factor receptor 2 (HER2): brightfield tricolor visualization of HER2 protein, the HER2 gene, and chromosome 17 centromere (CEN17) in formalin-fixed, paraffin-embedded breast cancer tissue sections.	Paraffin	197-205	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-65
22534715-7	2012	Interestingly, direct DNA sequencing of the paraffin-embedded tumor sample identified a novel R248Q mutation in the TP53 gene.	Paraffin	44-52	tumor protein p53	Homo sapiens	116-120
22077630-4	2012	Gene mutations in KIT exons 9, 11, 13, and 17 were analyzed using paraffin-embedded tissue, and two different sets of primers with direct sequencing after polymerase chain reaction (PCR) for exon 9, 11, 13, and 17, and cloning of PCR products for exon 11.	Paraffin	66-74	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	18-21
23626605-2	2012	MATERIALS AND METHODS: [corrected] P16INK4a expression was evaluated by immunohistochemistry in 78 paraffin-embedded tissue samples including 39 normal cervical tissues, 11 low-grade CINs, 11 high-grade CINs, 22 cervical SCCs and 8 cervical adenocarcinomas.	Paraffin	99-107	cyclin dependent kinase inhibitor 2A	Homo sapiens	35-43
22150625-9	2012	In tumours still considered stage T1 after re-evaluation, HER2 was investigated by immunohistochemistry of paraffin-embedded material and scored according to the guidelines used in breast cancer.	Paraffin	107-115	erb-b2 receptor tyrosine kinase 2	Homo sapiens	58-62
22524657-2	2012	It could detect HLA-A, -B, and -C antigens in formalin-fixed paraffin embedded tissues.	Paraffin	61-69	major histocompatibility complex, class I, A	Homo sapiens	16-33
21862261-6	2012	BRAF(V600E) mutation analysis was performed by polymerase chain reaction (PCR)-based amplification of DNA extracted from paraffin-embedded tumor specimens, and the relationship between BRAF(V600E) mutation and various prognostic factors was investigated.	Paraffin	121-129	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	0-5
22493362-3	2012	Furthermore, protein expression of SLPI in 71 paraffin-embedded NPC biopsies was assessed by immunohistochemistry.	Paraffin	46-54	secretory leukocyte peptidase inhibitor	Homo sapiens	35-39
22179975-4	2012	The aim of the present study was to develop a method for the detection of chimeric PAX8-PPARG transcripts in formalin-fixed paraffin-embedded (FFPE) thyroid tumor samples by conventional RT-PCR.	Paraffin	124-132	peroxisome proliferator activated receptor gamma	Homo sapiens	88-93
22376167-5	2012	The BRAF V600E mutations were detected using direct sequencing of genomic DNA that was isolated from formalin-fixed paraffin-embedded tumor tissues.	Paraffin	116-124	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	4-8
22781601-3	2012	Histological and immunohistochemical staining were applied to other 25 cases of ALCL and paraffin-embedded tissue from human anaplastic large-cell lymphoma Karpas 299 cells to detect the protein of CD99 and ALK.	Paraffin	89-97	CD99 molecule (Xg blood group)	Homo sapiens	198-202
22374427-3	2012	METHODS: The expression of ER-alpha, ER-Beta1 and ER-Beta2 in the paraffin-embedded sections of 162 invasive luminal subtype breast cancer patients was detected with an immunohistochemical staining method.	Paraffin	66-74	estrogen receptor 1	Homo sapiens	27-35
22449154-2	2012	MATERIAL AND METHODS: immunohistochemical expression of CD117 and PDGFRA was evaluated in 99 paraffin-embedded GISTs in conjunction with KIT and PDGFRA mutational status.	Paraffin	93-101	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	56-61
22391175-2	2012	Using fluorescence in situ hybridization (FISH), the P53 gene was detected in paraffin-embedded tonsil tissues from 50 cases of DLBCL, while all the peripheral blood of patients was collected for detecting P53 protein in serum by using enzyme-linked immunosorbent assay (ELISA).	Paraffin	78-86	tumor protein p53	Homo sapiens	53-56
22316048-4	2012	METHODS: Two retrospective multi-site clinical studies examined GP88 expression by immunohistochemistry (IHC) analysis of paraffin-embedded breast tumor tissue sections from ER+ IDC patients (lymph node positive and negative, stage 1 to 3) in correlation with patients" survival outcomes.	Paraffin	122-130	granulin precursor	Homo sapiens	64-68
22316485-4	2012	The monoclonal antibody produced by hybridoma clone S79 specifically recognizes endogenous SURF-6 by Western and immunofluorescence analyses in various cultured human cells, and by immunohistochemistry in paraffin-embedded sections of human breast cancer samples.	Paraffin	205-213	surfeit 6	Homo sapiens	91-97
22052344-2	2012	We identified the same bcl-2/IgH fusion gene in             paraffin-embedded lymph node (LN) samples and BM samples using immunohistochemistry             (IHC), immunocytochemistry (ICC), cytologic morphology and fluorescence in situ             hybridization (FISH).	Paraffin	60-68	BCL2 apoptosis regulator	Homo sapiens	23-28
22052344-5	2012	Approximately 78.6% (44/56) of             the paraffin-embedded LN tissue sections that underwent FISH analysis had a bcl-2/IgH             translocation.	Paraffin	47-55	BCL2 apoptosis regulator	Homo sapiens	119-124
22190222-5	2012	Polymerase chain reaction was used to amplify exon 15 of the BRAF gene from paraffin-embedded thyroid tumor specimens, followed by direct sequencing to detect the BRAF(V600E) mutation.	Paraffin	76-84	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	61-65
21524815-10	2012	The expression of human VEGF was also checked by real-time polymerase chain reaction in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	104-112	vascular endothelial growth factor A	Homo sapiens	24-28
21971709-4	2012	The immunohistochemical expression of             the putative brain tumor stem cell markers CD133 and Nestin in paraffin sections             was analyzed using morphometry.	Paraffin	113-121	nestin	Homo sapiens	103-109
21861235-3	2012	METHODS: The expression of RhoGDI2 was detected in CRC cell lines, and 20 matched pairs of fresh CRC tissues, and 120 cases of clinical paraffin-embedded CRC tissues by real-time RT-PCR, Western blot, RT-PCR, or immunohistochemistry.	Paraffin	136-144	Rho GDP dissociation inhibitor beta	Homo sapiens	27-34
22872928-7	2012	The report establishes the benefits of slow Mohs paraffin wax-embedded tissue over frozen sections in terms of improved morphology, tissue preservation and immunocytochemical labelling with anti-CD34.	Paraffin	49-61	CD34 molecule	Homo sapiens	195-199
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Paraffin	52-60	epidermal growth factor receptor	Homo sapiens	119-123
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Paraffin	52-60	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-129
21861103-4	2012	The specific expression and subcellular distribution of S100A11 were examined in 78 paraffin-embedded lung cancers, 2 benign lung diseases as well as 22 healthy lung tissues by immunohistochemistry.	Paraffin	84-92	S100 calcium binding protein A11	Homo sapiens	56-63
23417399-4	2012	On serial paraffin sections, PGCs were detected immunohistochemically by expression of OCT4 and c-Kit, nerve fibers by beta-III-tubulin and stem cell factor (SCF) as a possible chemoattractive cue for PGC migration.	Paraffin	10-18	progastricsin	Homo sapiens	29-32
22330820-6	2012	The cellular distribution of ET-1 was assessed immunohistochemically in paraffin sections.	Paraffin	72-80	endothelin 1	Homo sapiens	29-33
22745528-5	2012	METHODS: Immunohistochemistry was performed for CD24 on the archival paraffin sections of retinoblastoma and correlated with clinicopathological features.	Paraffin	69-77	CD24 molecule	Homo sapiens	48-52
22639268-3	2012	This protocol describes a method to detect the diphosphorylated form of ERK (dpERK) on paraffin embedded tissue of early mouse embryo.	Paraffin	87-95	mitogen-activated protein kinase 1	Mus musculus	72-75
21993926-8	2012	Immunohistochemistry             of TRAIL was performed on paraffin-embedded plasmacytoma tissue sections.	Paraffin	59-67	TNF superfamily member 10	Homo sapiens	36-41
22234627-5	2012	HER-2 protein was quantified as total HER-2 protein expression (H2T) by the HERmark  assay (Monogram Biosciences, Inc., South San Francisco, CA) in formalin-fixed, paraffin-embedded tumor samples.	Paraffin	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
22234627-5	2012	HER-2 protein was quantified as total HER-2 protein expression (H2T) by the HERmark  assay (Monogram Biosciences, Inc., South San Francisco, CA) in formalin-fixed, paraffin-embedded tumor samples.	Paraffin	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-43
22310016-4	2012	Cytoplasmatic or membranous calreticulin overexpression in malignant or benign cells in paraffin-embedded tissues was determined using immunohistochemistry.	Paraffin	88-96	calreticulin	Homo sapiens	28-40
22246354-2	2011	METHODS: Envision immunohistochemistry was used to assay the expression levels of EphA7 and MTDH in the conventional paraffin-embedded sections from specimens of squamous cell cancer (n=45) and peritumoral normal tissues (n=10).	Paraffin	117-125	metadherin	Homo sapiens	92-96
22236543-3	2012	METHODS: In a total of 121 patients, PHD2 expression was investigated by immunohistochemistry in paraffin-embedded tissue and correlated with clinicopathological parameters and patient survival.	Paraffin	97-105	egl-9 family hypoxia inducible factor 1	Homo sapiens	37-41
22723849-3	2012	The expression levels of miR-196b were also validated in an independent cohort containing 128 formalin-fixed paraffin-embedded (FFPE) glioma samples using qRT-PCR.	Paraffin	109-117	microRNA 196b	Homo sapiens	25-33
22506009-3	2012	recently reported the presence of a canonical (V600E)B-RAF mutation in 57% of paraffin-embedded biopsies from LCH granuloma.	Paraffin	78-86	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	53-58
23188432-2	2012	PURPOSE: In the present study, we have evaluated the presence of E-cadherin (EC) in 34 cases of metastatic or non-metastatic invasive ductal breast carcinomas (IDC) by immunohistochemistry followed by transmission electron microscopy (TEM) evaluation on samples prepared from paraffin sections.	Paraffin	276-284	cadherin 1	Homo sapiens	65-75
22026810-2	2011	To detect cancer-specific somatic mutations in two hot-spot regions of PIK3CA gene, the helical and kinase domains (encoded by exons 9 and 20, respectively) in GBM and AA, the authors examined the respective sequences 31 paraffin-embedded samples (23 GBM and 8 AA).	Paraffin	221-229	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	71-77
22340379-12	2011	In paraffin-embedded sections, we also could observe by immunohistochemistry the CD4(+)IL-16(+) cells, CD8(+)IL-16(+) cells, CD19(+)IL-16(+) cells, and CD14(+)IL-16(+) cells.	Paraffin	3-11	CD4 molecule	Homo sapiens	81-84
22133054-4	2011	Immunohistochemistry (IHC) was performed to examine AEG-1 protein expression in paraffin-embedded tissues from 141 SGC patients.	Paraffin	80-88	metadherin	Homo sapiens	52-57
19925514-3	2011	METHODS: Immunohistochemical staining using antibodies against COX-2 was performed on paraffin sections of normal human eyes and selected eye tumours arising from cells expressing COX-2.	Paraffin	86-94	prostaglandin-endoperoxide synthase 2	Homo sapiens	63-68
22085302-3	2011	METHODS: IEX-1 expression was examined in paraffin-embedded specimens from 77 patients with epithelial ovarian tumors using immunohistochemistry.	Paraffin	42-50	immediate early response 3	Homo sapiens	9-14
22075385-2	2011	MATERIALS AND METHODS: Trop-2 expression was evaluated by immunohistochemistry (IHC) in paraffin-embedded tumor tissues, by real-time polymerase-chain-reaction (RT-PCR) and flow-cytometry in cell lines.	Paraffin	88-96	tumor associated calcium signal transducer 2	Homo sapiens	23-29
21572114-4	2011	Immunohistochemical staining for VEGF was performed on the paraffin blocks.	Paraffin	59-67	vascular endothelial growth factor A	Homo sapiens	33-37
22165133-3	2011	RESULTS: The expression of MKK4 in 48 cases of metastasis of lymph node group was significantly higher than 27 cases of without metastasis of lymph node group in 75 cases of paraffin-embedded OSCC samples (P &lt; 0.05).	Paraffin	174-182	mitogen-activated protein kinase kinase 4	Homo sapiens	27-31
21572321-9	2011	To conclude, mRNA expression levels of molecular markers in formalin-fixed paraffin-embedded specimens of primary gastric tumors can be useful for identifying patients with advanced gastric cancer who would most likely benefit from S-1 treatment.	Paraffin	75-83	proteasome 26S subunit, non-ATPase 1	Homo sapiens	232-235
22593804-3	2011	In this follow-up study, env protein expression was evaluated immunohistochemically in an additional 195 paraffin-embedded breast tumors from a second U.S. patient cohort (Baltimore, Maryland) and in 110 tumors from Chinese patients.	Paraffin	105-113	endogenous retrovirus group W member 1, envelope	Homo sapiens	25-28
22032578-8	2011	RESULTS: Immunohistochemical staining on the vessels of 32 paraffin-embedded GBM specimens revealed that all 32 (100%) specimens exhibited staining for PSMA to a variable extent.	Paraffin	59-67	folate hydrolase 1	Homo sapiens	152-156
21495021-5	2011	Among the enriched pathways, vascular endothelial growth factor (VEGF) pathway genes collectively were amplified, and alterations of this pathway were validated by fluorescence in situ hybridization (FISH) and immunohistochemistry analyses in 58 formalin-fixed, paraffin-embedded osteosarcoma archival tissues that had clinical follow-up information.	Paraffin	262-270	vascular endothelial growth factor A	Homo sapiens	65-69
22005870-4	2011	The protein expression of VHL and Bax was investigated by means of immunohistochemical analysis of paraffin-embedded clinical specimens from seventeen benign cartilage tumors and thirty-four chondrosarcomas.	Paraffin	99-107	BCL2 associated X, apoptosis regulator	Homo sapiens	34-37
22321542-2	2011	METHODS: Optimized oligonucleotide probe method was applied to detect EGFR mutations involving exons 18 - 21 using formalin fixed paraffin embedded tissue specimens of 309 NSCLC patients.	Paraffin	130-138	epidermal growth factor receptor	Homo sapiens	70-74
22321547-2	2011	METHODS: The EGFR gene exons 19 and 21 of paraffin-embedded tumor tissue were amplified by PCR, followed by direct sequencing in 282 surgically-removed specimens of NSCLC.	Paraffin	42-50	epidermal growth factor receptor	Homo sapiens	13-17
22321848-3	2011	And the expressions of uPA and uPAR in paraffin-embedded tissues were detected by immunohistochemistry.	Paraffin	39-47	plasminogen activator, urokinase	Homo sapiens	23-26
21289364-2	2011	PATIENTS AND METHODS: Using a novel assay, HER2 protein expression (H2T) was measured in formalin-fixed, paraffin-embedded primary breast tumors from 98 women treated with trastuzumab-based therapy for MBC.	Paraffin	105-113	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-47
22235214-4	2011	PATIENTS AND METHODS: The methylation pattern in the p16 gene promoter was analyzed by bisulfite direct sequencing in 43 paraffin-embedded formalin-fixed tissues from patients with HCC.	Paraffin	121-129	cyclin dependent kinase inhibitor 2A	Homo sapiens	53-56
21687944-1	2011	We examined the possibility that the localization of phosphorylated ERK1 and ERK2 (pERK1/2) can serve as a marker for the development of benign and borderline tumors as well as carcinoma of the ovary by an immunohistochemical method on ovarian paraffin sections, obtained from women aged 41-83 years.	Paraffin	244-252	mitogen-activated protein kinase 3	Homo sapiens	68-72
21687944-1	2011	We examined the possibility that the localization of phosphorylated ERK1 and ERK2 (pERK1/2) can serve as a marker for the development of benign and borderline tumors as well as carcinoma of the ovary by an immunohistochemical method on ovarian paraffin sections, obtained from women aged 41-83 years.	Paraffin	244-252	mitogen-activated protein kinase 1	Homo sapiens	77-81
21613637-5	2011	Expression of centromere protein F and survivin was detected through the immunohistochemical staining of paraffin-embedded tumour tissues and then scored.	Paraffin	105-113	centromere protein F	Homo sapiens	14-34
21933600-5	2011	METHODS: The expression of P53 protein and MDM-2 protein was immunohistochemically detected using monoclonal antibodies in 242 paraffin embedded tissues, including 30 normal brain tissues from patients with craniocerebral injury and 212 tissues from patients with primary glioma (grade I - II group: 5 cases of grade I, 119 cases of grade II; and grade III--IV group: 53 cases of grade III, and 35 cases of grade IV).	Paraffin	127-135	tumor protein p53	Homo sapiens	27-30
21908901-6	2011	Finally, we applied our assay to assess EGFR/HER2 dimerization in paraffin embedded cell pellets.	Paraffin	66-74	epidermal growth factor receptor	Homo sapiens	40-44
21908901-6	2011	Finally, we applied our assay to assess EGFR/HER2 dimerization in paraffin embedded cell pellets.	Paraffin	66-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-49
22866155-6	2011	DNA from paraffin-embedded tumor tissues was isolated and amplified for the exons of c-kit and pdgfra associated with a high frequency of mutations.	Paraffin	9-17	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	85-90
22866155-6	2011	DNA from paraffin-embedded tumor tissues was isolated and amplified for the exons of c-kit and pdgfra associated with a high frequency of mutations.	Paraffin	9-17	platelet derived growth factor receptor alpha	Homo sapiens	95-101
21625267-2	2011	Higher levels of iASPP proteins were examined in paraffin-embedded sections collected from 30 patients with prostate cancer using an immunohistochemical method.	Paraffin	49-57	protein phosphatase 1 regulatory subunit 13 like	Homo sapiens	17-22
21638088-4	2011	Here we describe the development of a monoclonal BRAF V600E mutation-specific antibody that can differentiate BRAF V600E and wild type protein in routinely processed formalin-fixed and paraffin-embedded tissue.	Paraffin	185-193	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	49-53
21693655-3	2011	PATIENTS AND METHODS: Epithelial p53 expression was evaluated using two immunohistochemical antibodies (DO7 and 1801) in formalin-fixed, paraffin-embedded tissue from patients with node-positive breast cancer who were randomized to four cycles of cyclophosphamide and one of three doses of doxorubicin (60, 75, or 90 mg/m(2); AC) and to receive four subsequent cycles of paclitaxel (T) or not.	Paraffin	137-145	tumor protein p53	Homo sapiens	33-36
21823022-2	2011	The streptavidin-biotin complex (SABC) immunohistochemical staining in paraffin-embedded tissues was used to detect the expression of VEGF in 23 cases of primary pterygia and 7 normal conjunctival specimens.	Paraffin	71-79	vascular endothelial growth factor A	Homo sapiens	134-138
21516079-3	2011	We report our experience of routine KRAS/BRAF mutation screening practice performed on 1130 formalin-fixed paraffin-embedded tumor samples from 992 colorectal cancer patients.	Paraffin	107-115	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	41-45
21866459-3	2011	MRP4 and P53 protein expression in the paraffin-embedded specimen were detected by immunohistochemistry.	Paraffin	39-47	tumor protein p53	Homo sapiens	9-12
21638088-4	2011	Here we describe the development of a monoclonal BRAF V600E mutation-specific antibody that can differentiate BRAF V600E and wild type protein in routinely processed formalin-fixed and paraffin-embedded tissue.	Paraffin	185-193	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	110-114
21329384-0	2011	Multiple reaction monitoring assay for pre-eclampsia related calcyclin peptides in formalin fixed paraffin embedded placenta.	Paraffin	98-106	S100 calcium binding protein A6	Homo sapiens	61-70
21551254-12	2011	Of note, there was significant overexpression of AQP1 in both mRNA and protein in the paraffin-embedded ACC cohort.	Paraffin	86-94	aquaporin 1 (Colton blood group)	Homo sapiens	49-53
21383546-9	2011	An increased percentage of immunoreactive cells and a higher staining intensity in cancerous vs. non-cancerous paraffin sections paralleled higher mRNA levels of OATP2A1, OATP3A1, OATP4A1 and OATP5A1 in cancerous tissues of HCC, CCC and MLT patients.	Paraffin	111-119	solute carrier organic anion transporter family member 4A1	Homo sapiens	180-187
21566511-3	2011	By using immunohistochemistry for adipophilin, which is a specific marker of lipid accumulation that can be applied to paraffin sections, we examined intracytoplasmic lipid in apocrine carcinomas.	Paraffin	119-127	perilipin 2	Homo sapiens	34-45
21474578-2	2011	EXPERIMENTAL DESIGN: The relationship between HOXB7 expression and clinical characteristics of CRC was analyzed in 224 paraffin-embedded archived CRC specimens by immunohistochemistry (IHC).	Paraffin	119-127	homeobox B7	Homo sapiens	46-51
21208645-4	2011	The microvessel density in paraffin sections from 97 patients was correlated with Twist1 expression up-regulation.	Paraffin	27-35	twist family bHLH transcription factor 1	Homo sapiens	82-88
21875481-4	2011	The expression of p-ERK1/2 protein was verified by immunohistochemistry in 126 paraffin-embeded specimens, including 19 normal esophageal mucosa, 55 esophageal carcinomas in situ and 52 invasive carcinomas.	Paraffin	79-87	mitogen-activated protein kinase 3	Homo sapiens	20-26
21875481-12	2011	In the 126 cases of paraffin-embeded specimens, positive expressions of both p-ERK1 and p-ERK2 in esophageal cancer tissues were 7.7% (4/52), significantly lower than those in adjacent normal mucosa (31.6%, 6/19) and carcinoma in situ (85.5%, 47/55, P &lt; 0.05).	Paraffin	20-28	mitogen-activated protein kinase 3	Homo sapiens	79-83
21875481-12	2011	In the 126 cases of paraffin-embeded specimens, positive expressions of both p-ERK1 and p-ERK2 in esophageal cancer tissues were 7.7% (4/52), significantly lower than those in adjacent normal mucosa (31.6%, 6/19) and carcinoma in situ (85.5%, 47/55, P &lt; 0.05).	Paraffin	20-28	mitogen-activated protein kinase 1	Homo sapiens	90-94
21383546-9	2011	An increased percentage of immunoreactive cells and a higher staining intensity in cancerous vs. non-cancerous paraffin sections paralleled higher mRNA levels of OATP2A1, OATP3A1, OATP4A1 and OATP5A1 in cancerous tissues of HCC, CCC and MLT patients.	Paraffin	111-119	solute carrier organic anion transporter family member 5A1	Homo sapiens	192-199
21488175-9	2011	In conclusion, IHC for Her2/neu, ER and PR performed on formalin-fixed, paraffin-embedded cell blocks prepared from fresh FNA and serous fluid is reliable in predicting the expression of these markers when correlated with IHC and FISH performed on the corresponding tumor tissue.	Paraffin	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-31
21425146-4	2011	METHODS: The goal of this study was to assess, in formalin-fixed, paraffin-embedded tumor tissue, the association between miR-137 promoter methylation and survival (both overall and disease free) and with prognostic factors including stage, tumor size, lymph node positivity, tumor grade, and surgical tumor margin positivity.	Paraffin	66-74	microRNA 137	Homo sapiens	122-129
21076843-4	2011	METHODS: The expression of RECK, MMP-2, and MMP-9 in paraffin sections of hamster and human CCA specimens was analyzed by immunohistochemistry.	Paraffin	53-61	reversion inducing cysteine rich protein with kazal motifs	Homo sapiens	27-31
19395284-3	2011	PATIENTS AND METHODS: Immunostaining with Mel-18 specific antibodies was performed on paraffin sections from 202 patients.	Paraffin	86-94	polycomb group ring finger 2	Homo sapiens	42-48
20652725-6	2011	EGFR immunohistochemistry staining was performed on paraffin-embedded sections with a mouse monoclonal antibody (clone 2-18C9; Dako).	Paraffin	52-60	epidermal growth factor receptor	Homo sapiens	0-4
21598493-3	2011	Different particle size quantum dots fluorescent probes were applied to detect P53 protein and Bcl-2 protein simultaneously in paraffin-embedded tissue section of human tongue squamous cell carcinoma under fluorescent microscope.	Paraffin	127-135	tumor protein p53	Homo sapiens	79-82
21598493-3	2011	Different particle size quantum dots fluorescent probes were applied to detect P53 protein and Bcl-2 protein simultaneously in paraffin-embedded tissue section of human tongue squamous cell carcinoma under fluorescent microscope.	Paraffin	127-135	BCL2 apoptosis regulator	Homo sapiens	95-100
21598493-6	2011	P53 protein and Bcl-2 protein can be combined with different particle size quantum dots fluorescent probes respectively in the same paraffin-embedded tissue section of human tongue squamous cell carcinoma and two kinds of fluorescene can be observed.	Paraffin	132-140	tumor protein p53	Homo sapiens	0-3
21598493-6	2011	P53 protein and Bcl-2 protein can be combined with different particle size quantum dots fluorescent probes respectively in the same paraffin-embedded tissue section of human tongue squamous cell carcinoma and two kinds of fluorescene can be observed.	Paraffin	132-140	BCL2 apoptosis regulator	Homo sapiens	16-21
21436696-3	2011	METHODS: Protein expression levels of TSLC1 was explored by semiquantitative immunohistochemical staining on archival formalin-fixed, paraffin-embedded pathological specimen consisting of 30 normal ovaries, 30 ovarian cystadenomas, 40 borderline ovarian tumors, and 160 invasive ovarian carcinomas.	Paraffin	134-142	cell adhesion molecule 1	Homo sapiens	38-43
21595169-5	2011	MATERIAL AND METHOD: An immunohistochemical assessment of cyclins A, B1, D1 and E expression was performed in the paraffin-embedded tumor tissues of 19 patients (9 men and 10 women).	Paraffin	114-122	cyclin A2	Homo sapiens	58-81
20405295-2	2011	METHODS: p16 and EGFR expression was investigated by immunohistochemistry from paraffin-embedded tissue in 39 patients with adenocarcinoma of the uterine cervix.	Paraffin	79-87	cyclin dependent kinase inhibitor 2A	Homo sapiens	9-12
21575498-3	2011	METHODS: The role of RhoA and NF-kappaB in gastric carcinoma was assessed by tissue array technology and the levels of RhoA and NF-kappaB expression in paraffin-embedded tissues was quantified by immunohistochemistry from 189 cases of gastric carcinoma, 54 cases of their adjacent tissues, and 32 cases of normal gastric mucosa.	Paraffin	152-160	ras homolog family member A	Homo sapiens	119-123
21575498-3	2011	METHODS: The role of RhoA and NF-kappaB in gastric carcinoma was assessed by tissue array technology and the levels of RhoA and NF-kappaB expression in paraffin-embedded tissues was quantified by immunohistochemistry from 189 cases of gastric carcinoma, 54 cases of their adjacent tissues, and 32 cases of normal gastric mucosa.	Paraffin	152-160	nuclear factor kappa B subunit 1	Homo sapiens	128-137
21453513-6	2011	Expression of IFN-gamma Ralpha in the tumors was determined by immunohistochemistry analysis of paraffin-embedded tissues.	Paraffin	96-104	interferon gamma	Homo sapiens	14-23
21498700-5	2011	KIT exon 10 was amplified from archival paraffin-embedded MCC specimens by PCR and sequenced.	Paraffin	40-48	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-3
20405295-2	2011	METHODS: p16 and EGFR expression was investigated by immunohistochemistry from paraffin-embedded tissue in 39 patients with adenocarcinoma of the uterine cervix.	Paraffin	79-87	epidermal growth factor receptor	Homo sapiens	17-21
21208810-4	2011	In addition, the activation status of VEGFR2/KDR receptors was investigated in formalin-fixed paraffin embedded tissues and related to VEGF.	Paraffin	94-102	vascular endothelial growth factor A	Homo sapiens	38-42
21204706-5	2011	We analyzed the HER-2 codon 655 polymorphisms in paraffin block sections from 58 breast cancer patients and 55 control subjects and evaluated the association of the polymorphic alleles with breast cancer.	Paraffin	49-57	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-21
20567952-4	2011	CD24 expression was examined immunohistochemically on paraffin-embedded tissue specimens from 207 patients who underwent surgical treatment for gallbladder carcinoma in the period between January 2004 and May 2009.	Paraffin	54-62	CD24 molecule	Homo sapiens	0-4
20473863-6	2011	Immunohistochemical staining of GRP78 was performed on archival paraffin-embedded formalin-fixed tumor specimens obtained from 48 female breast cancer patients before chemotherapy treatment.	Paraffin	64-72	heat shock protein family A (Hsp70) member 5	Homo sapiens	32-37
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Paraffin	158-166	epidermal growth factor receptor	Homo sapiens	55-59
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Paraffin	158-166	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	67-71
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Paraffin	158-166	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	76-82
21609571-2	2011	METHODS: EnVisiom immunohistochemical methods was used for determining the expressions of EphA7 and MTDH in routinely paraffin-embedded sections of surgically-resected specimens from 108 cases with gallbladder adenocarcinoma, 15 cases with adenomatous polyp and 35 cases with chronic cholecystitis treated from June 1996 to June 2006.	Paraffin	118-126	metadherin	Homo sapiens	100-104
20851148-3	2011	Moreover, previous immunohistochemical investigations were restricted to frozen sections from perfusion-fixed rodent brain, largely due to the limited availability of MOR antibodies that effectively stain paraffin-embedded tissues.	Paraffin	205-213	opioid receptor, mu 1	Mus musculus	167-170
20848448-3	2011	METHODS: p16 immunohistochemistry (IHC) was assessed in archival paraffin-embedded material for 55 patients with locally advanced SCCHN treated with a uniform regimen of cisplatin and radiation.	Paraffin	65-73	cyclin dependent kinase inhibitor 2A	Homo sapiens	9-12
21270602-3	2011	MATERIALS AND METHODS: : Immunohistochemical analysis for KIT expression was performed on paraffin sections from 45 patients: 30 primary and 15 recurrent tumors.	Paraffin	90-98	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	58-61
21283737-0	2011	Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay.	Paraffin	95-103	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	51-56
21251264-8	2011	Validation of FABP-1 was performed via antibody immunohistochemistry on formalin-fixed paraffin embedded pancreatic tissue microarrays (FFPE TMA).	Paraffin	87-95	fatty acid binding protein 1	Homo sapiens	14-20
22053664-1	2011	The expression of p16 as a tumor suppressor protein was evaluated in a retrospective analysis of paraffin-embedded tissue specimens of leiomyosarcoma (LMS), leiomyoma (LM) and normal myometrium.	Paraffin	97-105	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21
21791906-5	2011	The combination of primary and secondary antibodies that could simultaneously detect the T lymphocyte antigens CD4 or CD8, CD57 and TCRbeta in histochemical analysis of a paraffin-embedded human lymph node section was established, and was successfully applied to a human tissue section infiltrated with T lymphocytes that express these markers.	Paraffin	171-179	T cell receptor beta locus	Homo sapiens	132-139
21224371-4	2011	EXPERIMENTAL DESIGN: EpCAM protein expression was evaluated in 74 samples of formalin-fixed, paraffin-embedded NET tissue by immunohistochemistry.	Paraffin	93-101	epithelial cell adhesion molecule	Homo sapiens	21-26
21131835-1	2011	The aim of the study was to assess the expression of cyclooxygenases (COX)-2 in nonepithelial ovarian malignancies.COX-2 immunohistochemical staining was performed on newly prepared deparaffinized slides from formalin-fixed, paraffin-embedded archival tissue blocks of unselected nonepithelial ovarian malignancies diagnosed between January 1993 and October 2009 after reconfirmation of the diagnosis.	Paraffin	184-192	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	115-120
22442608-2	2011	MATERIALS AND METHODS: The standard immunohistochemical method along with MIB-1 and DO-7; DAKO antibodies was used to study the expression of p53 and ki-67 in paraffin-embedded tissue specimens.	Paraffin	159-167	tumor protein p53	Homo sapiens	142-145
22242209-2	2011	We assessed the immunohistochemical expression of p53 and P-gp using formalin-fixed, paraffin-embedded specimens in 108 patients diagnosed with de novo DLBC.	Paraffin	85-93	tumor protein p53	Homo sapiens	50-53
21717364-3	2011	The aim of this chapter is to comprehensively overview the materials and methods to perform the endometrial biopsy and to detect Claudin-4 in paraffin-embedded samples of endometrium.	Paraffin	142-150	claudin 4	Homo sapiens	129-138
21109929-3	2011	In this study, we performed immunohistochemical analysis of the expression of hMena protein in paraffin-embedded archival tissues of infiltrating ductal carcinomas (IDCs) obtained from 52 cases.	Paraffin	95-103	ENAH actin regulator	Homo sapiens	78-83
21134821-7	2010	All these cancers should be tested for HER2 on paraffin block resection or biopsy specimens of the primary tumour or metastases.	Paraffin	47-55	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-43
21866462-2	2011	Since ER status is a prognostic and predictive factor in some cancers, we analysed the immunohistochemical expression of ERalpha and ERbeta in Reed-Sternberg (RS) cells in paraffin-embedded lymph node specimens from 27 children with classical Hodgkin lymphoma (HL) in relation to histological type, clinical stage, age, and gender.	Paraffin	172-180	estrogen receptor 1	Homo sapiens	121-128
20444850-3	2010	PATIENTS AND METHODS: Mel-18 was detected by immunohistochemistry in paraffin-embedded tissues from 287 breast cancer patients, of which 287 were from primary cancer sites, 63 from matched adjacent noncancerous sites, and 35 from metastatic lymph nodes.	Paraffin	69-77	polycomb group ring finger 2	Homo sapiens	22-28
20455003-4	2010	Here we immunohistochemically assessed Y705-phosphorylated STAT3 (pY705-STAT3) in formalin-fixed, paraffin-embedded specimens of 111 patients with supratentorial glioblastomas and 25 patients with supratentorial grade III gliomas.	Paraffin	98-106	signal transducer and activator of transcription 3	Homo sapiens	59-64
20801641-2	2010	METHODS: Immunoreactivity of MMP-9 and TIMP-1 by carcinoma cells, lymphocytes and fibroblasts in archival specimens of paraffin-embedded primary tumours were retrospectively associated with outcome in 340 consecutive patients completely resected for CRC stages II-IV and subsequently treated with adjuvant 5-fluorouracil.	Paraffin	119-127	TIMP metallopeptidase inhibitor 1	Homo sapiens	39-45
20455003-4	2010	Here we immunohistochemically assessed Y705-phosphorylated STAT3 (pY705-STAT3) in formalin-fixed, paraffin-embedded specimens of 111 patients with supratentorial glioblastomas and 25 patients with supratentorial grade III gliomas.	Paraffin	98-106	signal transducer and activator of transcription 3	Homo sapiens	66-77
20461443-3	2010	We aimed to comprehensively review the evidence for the prognostic usefulness of p53 immunohistochemical expression in paraffin-embedded tissue specimens from diffusely infiltrating astrocytomas.	Paraffin	119-127	tumor protein p53	Homo sapiens	81-84
20961282-4	2010	The expression of NIS protein was investigated by immunohistochemistry in paraffin-embedded tissue sections using anti-hNIS monoclonal antibody by the labeled streptavidin-biotin method.	Paraffin	74-82	solute carrier family 5 member 5	Homo sapiens	18-21
19936974-4	2010	The expression patterns of mTOR and p70S6K in paraffin-embedded specimens gathered from 65 patients with primary osteosarcoma were detected by the method of immunohistochemistry using antibodies against mTOR and p70S6K.	Paraffin	46-54	mechanistic target of rapamycin kinase	Homo sapiens	27-31
21080877-2	2010	METHODS: PDGFRA expression was examined in 100 human osteosarcomas by immunohistochemistry using paraffin embedded tumour tissues, and capillary sequencing of genomic DNA was performed to search for mutations in exons 12 and 18 of the PDGFRA gene.	Paraffin	97-105	platelet derived growth factor receptor alpha	Homo sapiens	9-15
20558462-2	2010	METHODS: Immunohistochemical staining was performed to detect the expression of CD147 and vascular endothelial growth factor in paraffin-embedded sections from 62 bone marrow biopsies obtained from an equal number of patients with newly diagnosed acute myeloid leukemia.	Paraffin	128-136	vascular endothelial growth factor A	Homo sapiens	90-124
21351635-3	2010	Immunohistochemical staining were used to analyze the expressions of P16 protein in paraffin-embedded tissues from these 90 residing patients with lung cancer.	Paraffin	84-92	cyclin dependent kinase inhibitor 2A	Homo sapiens	69-72
21106507-4	2010	First, we analyzed the expression of CAV1 by immunostaining a tissue microarray containing 43 paraffin-embedded ESFT tumors with known EWS translocations.	Paraffin	94-102	caveolin 1	Homo sapiens	37-41
21036706-3	2010	In this study, the expression of filamin A (FLNA) and vascular endothelial growth factor (VEGF) in paraffin-embedded tumor samples from patients with well-characterized lung tumors was immunohistochemically analyzed and compared with clinical variables and survival outcome.	Paraffin	99-107	filamin A	Homo sapiens	33-42
21036706-3	2010	In this study, the expression of filamin A (FLNA) and vascular endothelial growth factor (VEGF) in paraffin-embedded tumor samples from patients with well-characterized lung tumors was immunohistochemically analyzed and compared with clinical variables and survival outcome.	Paraffin	99-107	filamin A	Homo sapiens	44-48
21036706-3	2010	In this study, the expression of filamin A (FLNA) and vascular endothelial growth factor (VEGF) in paraffin-embedded tumor samples from patients with well-characterized lung tumors was immunohistochemically analyzed and compared with clinical variables and survival outcome.	Paraffin	99-107	vascular endothelial growth factor A	Homo sapiens	90-94
20594581-0	2010	Diagnostic utility of dual-color break-apart chromogenic in situ hybridization for the detection of rearranged SS18 in formalin-fixed, paraffin-embedded synovial sarcoma.	Paraffin	135-143	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	111-115
20132196-4	2010	We performed immunohistochemical staining for NF-kappaB (p65) on paraffin-embedded sections of the tumour and corresponding normal tissues.	Paraffin	65-73	nuclear factor kappa B subunit 1	Homo sapiens	46-55
20594584-4	2010	KIT expression was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded material.	Paraffin	71-79	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-3
20811686-5	2010	Methylation-specific PCR (MSP) was performed to study inactivation of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes in 37 cases of paraffin embedded oral cancer.	Paraffin	136-144	secreted frizzled related protein 2	Homo sapiens	78-84
20044319-7	2010	As CD34 is also expressed by endothelial cells, we immunohistochemically stained 2-mum-thick serial paraffin sections of fat tissue obtained from various parts of formalin-fixed cadavers with anti-CD31 and anti-CD34 antibodies to distinguish ASCs from endothelial cells.	Paraffin	100-108	CD34 molecule	Homo sapiens	3-7
20811686-5	2010	Methylation-specific PCR (MSP) was performed to study inactivation of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes in 37 cases of paraffin embedded oral cancer.	Paraffin	136-144	dickkopf WNT signaling pathway inhibitor 3	Homo sapiens	109-114
20811686-5	2010	Methylation-specific PCR (MSP) was performed to study inactivation of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes in 37 cases of paraffin embedded oral cancer.	Paraffin	136-144	secreted frizzled related protein 4	Homo sapiens	86-92
20811686-5	2010	Methylation-specific PCR (MSP) was performed to study inactivation of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes in 37 cases of paraffin embedded oral cancer.	Paraffin	136-144	secreted frizzled related protein 5	Homo sapiens	94-100
20808855-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: FAAH immunoreactivity (FAAH-IR) was assessed in formalin-fixed paraffin-embedded non-malignant and tumour cores from 412 patients with prostate cancer.	Paraffin	95-103	fatty acid amide hydrolase	Homo sapiens	32-36
21051833-2	2010	METHODS: Envision Tm immunohistochemistry was used to detect the expression level of CHK1 and PLK1 in conventional paraffin-embedded sections from specimens of primary foci (n=59)and metastatic foci of lymph node (n=42) of gastric cancer, peritumoral tissues (n=20), and benign lesions of the stomach (n=95).	Paraffin	115-123	checkpoint kinase 1	Homo sapiens	85-89
20519626-3	2010	Here, using 2 orthogonal technologies for detecting cancer-associated mutations in formalin-fixed, paraffin-embedded material, we identified the oncogenic BRAF V600E mutation in 35 of 61 archived specimens (57%).	Paraffin	99-107	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	155-159
19554484-6	2010	The expression of ABI1 protein was measured using immunohistochemical staining of paraffin-embedded tissue specimens.	Paraffin	82-90	abl interactor 1	Homo sapiens	18-22
20700126-0	2010	In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues.	Paraffin	93-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-30
21180995-2	2010	METHODS: An immunohistochemistry study has been made on the protein caspase-3 in 17 of paraffin blocks of papillary carcinoma of the thyroid and 20 cases of colloid goiter, using SAMBA 4000   (System of Microscopic Analysis of Automatic Search), aiming analysis of the two variables: marker index and optical density.	Paraffin	87-95	caspase 3	Homo sapiens	68-77
20931533-3	2010	HER2 expression level and HER2 gene copy number in formalin-fixed and paraffin embedded tumor samples were detected by immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH), and the relationship between HER2 gene GH and clinicopathological characteristics were analyzed.	Paraffin	70-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
20736744-11	2010	The TMPRSS2 dual-color break-apart FISH probe cocktail provides a simple and reliable method for the detection of TMPRSS2-related genetic alterations in formalin-fixed paraffin-embedded tissue.	Paraffin	168-176	transmembrane serine protease 2	Homo sapiens	4-11
20736744-11	2010	The TMPRSS2 dual-color break-apart FISH probe cocktail provides a simple and reliable method for the detection of TMPRSS2-related genetic alterations in formalin-fixed paraffin-embedded tissue.	Paraffin	168-176	transmembrane serine protease 2	Homo sapiens	114-121
20670148-5	2010	Real-time polymerase chain reaction identifies the most common BRAF mutation, V600E, in frozen or paraffin-embedded colorectal cancer tissue.	Paraffin	98-106	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	63-67
20856894-5	2010	EXPERIMENTAL DESIGN: CD10 expression was evaluated by quantitative RT-PCR and immunohistochemistry using paraffin-embedded samples of normal breast tissue (n = 11); of morphologically normal ducts associated with DCIS (n = 10); and of DCIS without an invasive component (n = 154).	Paraffin	105-113	membrane metalloendopeptidase	Homo sapiens	21-25
20478579-5	2010	MATERIALS AND METHODS: PITX2 methylation status was assessed in formalin fixed, paraffin embedded prostatectomy tumor tissue samples from 476 patients from a total of 4 institutions on customized EpiChip PITX2 microarrays.	Paraffin	80-88	paired like homeodomain 2	Homo sapiens	23-28
21761367-1	2010	A phospho-tyrosine 537-ERalpha (p-Y537-ERalpha) antibody was validated for immunohistochemistry of formalin-fixed paraffin-embedded human breast cancer biopsies and used to interrogate multiple ER positive breast cancer cases present on tissue microarrays already constructed by the Manitoba Breast Tumor Bank.	Paraffin	114-122	estrogen receptor 1	Homo sapiens	23-30
21761367-1	2010	A phospho-tyrosine 537-ERalpha (p-Y537-ERalpha) antibody was validated for immunohistochemistry of formalin-fixed paraffin-embedded human breast cancer biopsies and used to interrogate multiple ER positive breast cancer cases present on tissue microarrays already constructed by the Manitoba Breast Tumor Bank.	Paraffin	114-122	estrogen receptor 1	Homo sapiens	39-46
20704797-3	2010	EnVison immunohistochemistry was used to detect the expression of GRP78 and GRP94 in the conventional paraffin-embedded liver sections.	Paraffin	102-110	heat shock protein family A (Hsp70) member 5	Homo sapiens	66-71
20216402-0	2010	Double immunohistochemical staining method for HIF-1alpha and its regulators PHD2 and PHD3 in formalin-fixed paraffin-embedded tissues.	Paraffin	109-117	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-57
20431032-3	2010	The aim of this study was to develop and evaluate the performance of a novel real-time PCR and post-PCR fluorescence melting curve analysis assay for the detection of IDH1 and IDH2 mutations in routine formalin-fixed, paraffin-embedded tissues of brain biopsies.	Paraffin	218-226	isocitrate dehydrogenase (NADP(+)) 2	Homo sapiens	176-180
20688016-1	2010	OBJECTIVE: To compare immunohistochemical estrogen receptor expression on formalin-fixed, paraffin-embedded breast carcinoma tissue sections by using regular, extended microwave heating and pressure cooker technique for heat induced antigen retrieval.	Paraffin	90-98	estrogen receptor 1	Homo sapiens	42-59
20689131-1	2010	The mammalian target of rapamycin (mTOR) signaling pathway was studied using immunohistochemical stains on paraffin-embedded tumor tissue from two patients with anaplastic thyroid carcinoma (ATC) and on paraffin-embedded normal thyroid tissue from 23 control patients.	Paraffin	107-115	mechanistic target of rapamycin kinase	Homo sapiens	4-33
20689131-1	2010	The mammalian target of rapamycin (mTOR) signaling pathway was studied using immunohistochemical stains on paraffin-embedded tumor tissue from two patients with anaplastic thyroid carcinoma (ATC) and on paraffin-embedded normal thyroid tissue from 23 control patients.	Paraffin	107-115	mechanistic target of rapamycin kinase	Homo sapiens	35-39
20689131-1	2010	The mammalian target of rapamycin (mTOR) signaling pathway was studied using immunohistochemical stains on paraffin-embedded tumor tissue from two patients with anaplastic thyroid carcinoma (ATC) and on paraffin-embedded normal thyroid tissue from 23 control patients.	Paraffin	203-211	mechanistic target of rapamycin kinase	Homo sapiens	4-33
20689131-1	2010	The mammalian target of rapamycin (mTOR) signaling pathway was studied using immunohistochemical stains on paraffin-embedded tumor tissue from two patients with anaplastic thyroid carcinoma (ATC) and on paraffin-embedded normal thyroid tissue from 23 control patients.	Paraffin	203-211	mechanistic target of rapamycin kinase	Homo sapiens	35-39
20699501-11	2010	CONCLUSION: Activated B and T cells express COX-1 and COX-2 in paraffin-embedded tissue sections of chronic tonsillitis.	Paraffin	63-71	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	54-59
19900756-4	2010	Further comparisons of formalin-fixed paraffin-embedded human choriocarcinoma, mole, and non-cancer trophoblast tissues confirmed the initial findings of low miR-199b expression and SET upregulation in choriocarcinomas, suggesting that microRNA-dysregulated SET protein may account for the rapid growth seen with choriocarcinomas.	Paraffin	38-46	microRNA 199b	Homo sapiens	158-166
21151530-1	2010	We report here the results of the analytical validation of assays that measure HER2 total protein (H2T) and HER2 homodimer (H2D) expression in Formalin Fixed Paraffin Embedded (FFPE) breast cancer tumors as well as cell line controls.	Paraffin	158-166	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-83
20236756-6	2010	Immunohistochemical analysis showed that 51 of 75 (68.0%) paraffin-embedded archival oligodendroglioma samples exhibited high expression of AEG-1.	Paraffin	58-66	metadherin	Homo sapiens	140-145
20459648-3	2010	The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed.	Paraffin	50-58	tumor protein p53	Homo sapiens	28-31
20502183-9	2010	In conclusion, we showed that the Biomed-2 TCR PCR worked well with DNA from paraffin-embedded tissue, revealing a high-clonality detection rate in CTCL, and thus should be highly recommended for routine molecular analysis.	Paraffin	77-85	TSPY like 2	Homo sapiens	148-152
20491588-2	2010	The mRNA and protein expression levels of Wnt1/beta-catenin genes in 70 ESCC and 15 adjacent noncancerous paraffin-embedded samples were determined by real-time quantitative polymerase chain reaction and immunohistochemical staining.	Paraffin	106-114	Wnt family member 1	Homo sapiens	42-46
20448346-4	2010	In the present study, we examined the expression of HMW-MAA in 95 paraffin-embedded, primary ALM lesions and 13 primary superficial spreading melanoma (SSM) lesions.	Paraffin	66-74	chondroitin sulfate proteoglycan 4	Homo sapiens	52-59
20304943-8	2010	Determination of PITX2 methylation in formalin-fixed and paraffin-embedded tissue samples from a cohort of 157 prostatectomy patients resulted in an excellent level of concordance of the clinical classification, as well as the measured output between the research assay and the Epichip PITX2.	Paraffin	57-65	paired like homeodomain 2	Homo sapiens	17-22
20371205-5	2010	We also sought to confirm the findings by sequencing the PTCH1 gene from DNA extracted from the paraffin-embedded tissue of these cases.	Paraffin	96-104	patched 1	Homo sapiens	57-62
20381697-3	2010	The carcinoembryonic antibody (anti-CEA) was immobilized on the modified magnetic particles, which were then attached on the surface of solid paraffin carbon paste electrode (SPCE) by an external magnetic field.	Paraffin	142-150	CEA cell adhesion molecule 3	Homo sapiens	36-39
20367313-10	2010	CONCLUSIONS: A multiplex polymerase chain reaction-based amplification followed by dideoxy-termination sequencing may be used advantageously for the evaluation of KRas and BRaf mutational status from formalin-fixed, paraffin-embedded samples.	Paraffin	216-224	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	172-176
20530420-2	2010	MATERIALS AND METHODS: The immunohistochemical expression of HIF1alpha was studied in formalin-fixed paraffin-embedded tissues from 60 patients who had undergone thoracic surgery for lung cancer (n=48) or pneumothorax (n=12) under OLV general anesthesia.	Paraffin	101-109	hypoxia inducible factor 1 subunit alpha	Homo sapiens	61-70
20492381-2	2010	METHODS: The expression of p-STAT3 was analyzed by immunohistochemistry using paraffin-embedded pretreatment cervical biopsy tissues.	Paraffin	78-86	signal transducer and activator of transcription 3	Homo sapiens	29-34
20207772-6	2010	RESULTS: The digital array detected and quantified rare gefitinib/erlotinib-sensitizing EGFR mutations (0.02%-9.26% abundance) that were present in formalin-fixed, paraffin-embedded samples of early-stage resectable lung tumors without an associated increase in gene copy number.	Paraffin	164-172	epidermal growth factor receptor	Homo sapiens	88-92
20375793-3	2010	METHODS: The expression of endothelial nitric oxide synthase was tested in formalin-fixed, paraffin-embedded tissues from specimens including 8 first trimester placentas, 3 partial hydatidiform moles, 20 complete hydatidiform moles, 2 invasive moles, and 5 choriocarcinomas.	Paraffin	91-99	nitric oxide synthase 3	Homo sapiens	27-60
20586029-2	2010	METHODS: Promoter methylation of the p14ARF gene was investigated by methylation-specific polymerase chain reaction in paraffin-embedded tissues from 76 patients with OSCC and 57 oral tissues used as healthy controls.	Paraffin	119-127	cyclin dependent kinase inhibitor 2A	Homo sapiens	37-43
20373884-4	2010	We, therefore, aim to investigate COX-2 expression in paraffin-embedded retinoblastoma specimens in a larger study group.	Paraffin	54-62	prostaglandin-endoperoxide synthase 2	Homo sapiens	34-39
20331873-4	2010	EGFR gene amplification was studied by fluorescence in situ hybridization using paraffin-embedded tissues.	Paraffin	80-88	epidermal growth factor receptor	Homo sapiens	0-4
19676046-5	2010	Furthermore, immunohistochemical analysis revealed that ILK1 protein was positive in 208 of 228 (91.2%) paraffin-embedded archival astrocytoma specimens.	Paraffin	104-112	integrin linked kinase	Homo sapiens	56-60
20056739-4	2010	RESULTS: The RT-PCR assay is applicable for detecting the various described fusion transcripts of PAX8/PPARG in formalin-fixed, paraffin-embedded thyroid tissue and in fine-needle aspirate biopsy washes from thyroid nodules.	Paraffin	128-136	peroxisome proliferator activated receptor gamma	Homo sapiens	103-108
20060709-5	2010	Trop-2 protein expression was then examined by immunohistochemistry in matched formalin-fixed paraffin-embedded EOC samples and in 13 normal ovaries.	Paraffin	94-102	tumor associated calcium signal transducer 2	Homo sapiens	0-6
19184568-3	2010	Their hK11 expression levels were examined by immunostaining on paraffin-embedded tumor specimens.	Paraffin	64-72	kallikrein related peptidase 11	Homo sapiens	6-10
20093389-0	2010	Mutation detection of epidermal growth factor receptor and KRAS genes using the smart amplification process version 2 from formalin-fixed, paraffin-embedded lung cancer tissue.	Paraffin	139-147	epidermal growth factor receptor	Homo sapiens	22-54
20450759-2	2010	METHODS: Immunohistochemical study for CD34 was performed on formalin-fixed paraffin-embedded tissue blocks of 54 cases of brain tumors occurring in patients with refractory epilepsy.	Paraffin	76-84	CD34 molecule	Homo sapiens	39-43
20335127-2	2010	METHODS: Immunohistochemical EnVison method was used to detect the expressions of ER, VIM, CEA and p16 in paraffin-embedded tissues from 31 cases of primary endocervical adenocarcinomas and 30 cases of endometrial adenocarcinomas.	Paraffin	106-114	CEA cell adhesion molecule 3	Homo sapiens	91-94
20335127-2	2010	METHODS: Immunohistochemical EnVison method was used to detect the expressions of ER, VIM, CEA and p16 in paraffin-embedded tissues from 31 cases of primary endocervical adenocarcinomas and 30 cases of endometrial adenocarcinomas.	Paraffin	106-114	cyclin dependent kinase inhibitor 2A	Homo sapiens	99-102
21042029-5	2010	Immunohistolocalisation of TNF-alpha was performed on paraffin-embedded sections.	Paraffin	54-62	tumor necrosis factor	Homo sapiens	27-36
19900134-5	2010	METHODS: COX-2 expression assessment by immunohistochemistry was performed on deparaffinized sections of paraffin-embedded tissue blocks.	Paraffin	80-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	9-14
20460933-4	2010	METHODS: We evaluated the expression of mTOR pathway molecules in paraffin-embedded liver and kidney samples from patients with AR PKD and control specimens from animals as well as humans.	Paraffin	66-74	mechanistic target of rapamycin kinase	Homo sapiens	40-44
20390900-1	2010	In the present study the catalytic oxidation of an industrial organic solvent consisting predominantly of C-9 to C-10 paraffins and napthtenics and derived from low aromatic white spirit on CuO and Pt catalysts was investigated at ambient pressure and temperatures between 330 and 770 K. Catalysts were prepared in the laboratory and compared to commercial ones.	Paraffin	118-127	homeobox C10	Homo sapiens	113-117
20010306-3	2010	Mutation analysis of TP53 Exons 4 to 9 on DNA from formalin-fixed, paraffin-embedded specimens was performed by bidirectional DNA sequencing.	Paraffin	67-75	tumor protein p53	Homo sapiens	21-25
19767729-4	2010	This study aimed to validate a new polymerase chain reaction-based test, called multiplex ligation-dependent probe amplification (MLPA), as a simple and quick method to simultaneously assess HER-2/neu and TopoII alpha gene amplification status in paraffin-embedded breast cancer samples.	Paraffin	247-255	erb-b2 receptor tyrosine kinase 2	Homo sapiens	191-200
20027033-2	2010	METHODS: Immunostaining for poly(ADP-ribose) polymerase was performed in 186 paraffin-embedded, serous ovarian cancers.	Paraffin	77-85	poly(ADP-ribose) polymerase 1	Homo sapiens	28-55
20053761-2	2010	EpCAM expression was evaluated by real-time PCR and immunohistochemistry in a total of 56 USPC fresh-frozen biopsies and paraffin-embedded tissues.	Paraffin	121-129	epithelial cell adhesion molecule	Homo sapiens	0-5
20845990-4	2010	Furthermore, immunohistochemistry analysis showed highly expressed AEG-1 in 96 of 102 (94.1%) cases of paraffin-embedded archival RCC tissue.	Paraffin	103-111	metadherin	Homo sapiens	67-72
20049829-5	2010	(125)I-CQ-PBCA NPs labeled the A beta plaques from the AD human post-mortem frontal cortical sections on paraffin-fixed slides.	Paraffin	105-113	amyloid beta precursor protein	Homo sapiens	31-37
21372598-2	2010	METHODS: MKK4 expression in endometrial cancer was assessed by immunohistochemistry using 87 paraffin-embedded tissue specimens, and clinical data was collected via a retrospective chart review.	Paraffin	93-101	mitogen-activated protein kinase kinase 4	Homo sapiens	9-13
19104930-5	2009	In this study we have investigated the usefulness of several antibodies generated to specific phosphorylated sites within ERalpha for immunohistochemistry of formalin-fixed, paraffin-embedded human breast cancer biopsy samples.	Paraffin	174-182	estrogen receptor 1	Homo sapiens	122-129
19437143-4	2009	We investigated WT1 expression in 90 paraffin-embedded pituitary adenomas, including eight atypical adenomas, and in 28 nontumorous pituitary glands by immunohistochemistry.	Paraffin	37-45	WT1 transcription factor	Homo sapiens	16-19
20055873-3	2009	HIF-1alpha expression was assessed by immunohistochemistry in formalin-fixed, paraffin wax-embedded tumour sections.	Paraffin	78-90	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
19911196-0	2009	Vascular endothelial growth factor C mRNA expression is a prognostic factor in epithelial ovarian cancer as detected by kinetic RT-PCR in formalin-fixed paraffin-embedded tissue.	Paraffin	153-161	vascular endothelial growth factor C	Homo sapiens	0-36
19911196-13	2009	mRNA extracted from paraffin-embedded tumor samples is suitable for VEGF-C gene expression studies.	Paraffin	20-28	vascular endothelial growth factor C	Homo sapiens	68-74
19930682-7	2009	RESULTS: YB-1-specific Mab F-E2G5 associates with conformational binding epitopes mapping to two domains within the N-terminal half of the protein and detects nuclear YB-1 protein by immunohistochemistry in paraffin-embedded breast cancer tissues.	Paraffin	207-215	Y-box binding protein 1	Homo sapiens	9-13
19930682-7	2009	RESULTS: YB-1-specific Mab F-E2G5 associates with conformational binding epitopes mapping to two domains within the N-terminal half of the protein and detects nuclear YB-1 protein by immunohistochemistry in paraffin-embedded breast cancer tissues.	Paraffin	207-215	Y-box binding protein 1	Homo sapiens	167-171
19895696-4	2009	MATERIALS AND METHODS: VEGF expression was determined by immunohistochemistry using anti-VEGF antibody in paraffin embedded primary tumour tissue from 56 neuroblastoma patients.	Paraffin	106-114	vascular endothelial growth factor A	Homo sapiens	23-27
20009901-3	2009	METHODS: Nuclear factor-kappaB subunits p65 and p50 were detected in 159 paraffin tissues including normal cervical, precancerous (squamous intraepithelial lesions), and cervical carcinoma tissues by immunohistochemistry.	Paraffin	73-81	nuclear factor kappa B subunit 1	Homo sapiens	48-51
19546475-2	2009	Results obtained by immunohistochemistry and immunofluorescence on paraffin-embedded tissue and whole-mount preparations show that Toll-like receptors (TLRs) -3 and -7, recognizing viral RNA, and TLR4, recognizing lipopolysaccharide (membrane component of Gram-negative bacteria), are expressed in the myenteric and submucous plexuses of murine intestine and human ileum, and in DRGs primary sensory neurons.	Paraffin	67-75	toll-like receptor 4	Mus musculus	196-200
19661148-5	2009	Signaling transducers phosphorylated SMAD2/3, and signaling modulators SMAD6, MAN-1, inhibin alpha (INHA), and beta-glycan were detected in Bouins fixed, paraffin-embedded adult human testis sections using immunohistochemistry.	Paraffin	154-162	LEM domain containing 3	Homo sapiens	78-83
20120772-2	2009	METHODS: PDCD5 expression was determined by EnVision immunohistochemical staining in formalin-fixed and paraffin-embedded specimens obtained from 12 subjects with NP, 22 with BPH, and 22 with PCa.	Paraffin	104-112	programmed cell death 5	Homo sapiens	9-14
19675076-0	2009	Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue.	Paraffin	117-125	estrogen receptor 1	Homo sapiens	0-19
19675076-3	2009	Therefore, we tested if ER expression analysis by a quantitative method might be useful in this regard in formalin-fixed paraffin-embedded (FFPE) tissue.	Paraffin	121-129	estrogen receptor 1	Homo sapiens	24-26
19644957-6	2009	Furthermore, we showed high expression of AEG-1 in 99/200 (49.5%) paraffin-embedded archival NSCLC specimens.	Paraffin	66-74	metadherin	Homo sapiens	42-47
19852739-8	2009	In particular, paired-like homeodomain transcription factor 2 (PITX2) DNA methylation has been validated using a robust assay for paraffin-embedded tissue for clinically relevant outcome prediction in early breast cancer patients treated by adjuvant tamoxifen therapy.	Paraffin	130-138	paired like homeodomain 2	Homo sapiens	15-61
19852739-8	2009	In particular, paired-like homeodomain transcription factor 2 (PITX2) DNA methylation has been validated using a robust assay for paraffin-embedded tissue for clinically relevant outcome prediction in early breast cancer patients treated by adjuvant tamoxifen therapy.	Paraffin	130-138	paired like homeodomain 2	Homo sapiens	63-68
19789507-3	2009	MATERIAL/METHODS: Immunohistochemical analysis of mTOR was performed on paraffin-embedded tissue specimens obtained from 141 patients with endometrial carcinoma.	Paraffin	72-80	mechanistic target of rapamycin kinase	Homo sapiens	50-54
19805961-8	2009	A subsequent molecular analysis performed using reverse transcriptase-polymerase chain reaction with RNA extracted from paraffin-embedded tissue, revealed SYT/SSX1 fusion gene which confirmed the diagnosis of synovial sarcoma.	Paraffin	120-128	SSX family member 1	Homo sapiens	159-163
19673544-0	2009	MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections.	Paraffin	125-133	heat shock protein family A (Hsp70) member 5	Homo sapiens	59-91
19673544-0	2009	MALDI-ion mobility separation-mass spectrometry imaging of glucose-regulated protein 78 kDa (Grp78) in human formalin-fixed, paraffin-embedded pancreatic adenocarcinoma tissue sections.	Paraffin	125-133	heat shock protein family A (Hsp70) member 5	Homo sapiens	93-98
19430729-3	2009	In the present study, the TIMP-1 expression was investigated immunohistochemically in 112 formalin-fixed paraffin embedded astrocytomas and related to tumour grade and overall patient survival by scoring the TIMP-1 immunoreactivity of both tumour cells and blood vessels.	Paraffin	105-113	TIMP metallopeptidase inhibitor 1	Homo sapiens	26-32
19292734-7	2009	HER2 status was studied by immunohistochemistry and fluorescence in situ hybridization (FISH) on paraffin-embedded tissue.	Paraffin	97-105	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
19617878-3	2009	KIT protein expression was evaluated by immunohistochemistry using formalin-fixed paraffin-embedded tissue.	Paraffin	82-90	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-3
19796081-0	2009	Oligonucleotide probe array for p53 gene alteration analysis in DNA from formalin-fixed paraffin-embedded breast cancer tissues.	Paraffin	88-96	tumor protein p53	Homo sapiens	32-35
19796081-2	2009	We sequenced the p53 gene in DNA extracted from archival paraffin-embedded BC tissues and compared the results obtained from direct sequencing with those obtained by oligonucleotide probe array (OPA).	Paraffin	57-65	tumor protein p53	Homo sapiens	17-20
19861268-3	2009	The maximum and mean standard uptake values (SUVmax and SUVmean, respectively) were measured in each patient, and the expression of VEGF was measured on paraffin sections using immunohistochemistry.	Paraffin	153-161	vascular endothelial growth factor A	Homo sapiens	132-136
19525925-12	2009	The high concordance rate of silver enhanced in situ hybridization and fluorescence in situ hybridization for the detection of EGFR amplification in paraffin-embedded glioblastomas samples demonstrates that silver enhanced in situ hybridization is a valid and attractive alternative to fluorescence in situ hybridization.	Paraffin	149-157	epidermal growth factor receptor	Homo sapiens	127-131
19685571-11	2009	CD3 and CD26 can only be detected on frozen sections, while HBD-2 can only be detected on paraffin-embedded sections.	Paraffin	90-98	defensin beta 4A	Homo sapiens	60-65
19551847-2	2009	The evaluation of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression by immunohistochemistry (IHC) is performed routinely on formalin-fixed, paraffin-embedded needle-core (NC) or excision tissue block (TB) preparations, according to the American Society of Clinical Oncology/College of American Pathologist guidelines.	Paraffin	205-213	erb-b2 receptor tyrosine kinase 2	Homo sapiens	116-120
19723044-2	2009	Immunohistochemical analysis with COX-2 antibody was performed on 148 paraffin-embedded tissue specimens of patients who were diagnosed as CIN in our institute.	Paraffin	70-78	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	34-39
19671866-2	2009	Previous studies have separately reported elevated expression of BSP, OPN, or DSPP in prostate tumor paraffin sections.	Paraffin	101-109	integrin binding sialoprotein	Homo sapiens	65-68
19548138-2	2009	METHODS: CD147 and VEGF expression in paraffin-embedded specimens gathered from 53 patients with advanced RCC and 12 healthy controls were detected by the method of immunohistochemistry.	Paraffin	38-46	vascular endothelial growth factor A	Homo sapiens	19-23
19723114-2	2009	Our previous study showed a high expression rate of COX-2 in paraffin-embedded tissue specimens from patients with vulvar cancer.	Paraffin	61-69	prostaglandin-endoperoxide synthase 2	Homo sapiens	52-57
19635143-4	2009	METHODS: MGB-2 expression was evaluated by quantitative real time-PCR in fresh-frozen tissue biopsies and was validated by immunohistochemistry in matched formalin fixed-paraffin embedded tissue samples derived from a total of 106 EOC patients and 27 controls.	Paraffin	170-178	secretoglobin family 2A member 1	Homo sapiens	9-14
19450871-4	2009	METHODS: The expression of uPA/uPAR was examined on paraffin-embedded tissue sections from primary EOC (n=100), and matched metastatic lesions (n=30) of untreated patients, normal ovarian tissues (n=20) as well as 8 primary and metastatic EOC cell lines by immunohistochemistry.	Paraffin	52-60	plasminogen activator, urokinase	Homo sapiens	27-30
19488035-7	2009	We found that anti-CD44v6 and CD24 antibodies that were directly conjugated to quantum dots retained their ability to recognize antigen in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	155-163	CD24 molecule	Homo sapiens	30-34
19640195-4	2009	Expression of c-erbB-2 was evaluated by immunohistochemistry in paraffin-embedded sections.	Paraffin	64-72	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-22
19587327-3	2009	METHODS: We determined the expression pattern of vascular endothelial growth factor (VEGF) and three of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vestibular schwannomas associated with neurofibromatosis type 2 and from 22 sporadic schwannomas.	Paraffin	163-171	vascular endothelial growth factor A	Homo sapiens	49-83
19587327-3	2009	METHODS: We determined the expression pattern of vascular endothelial growth factor (VEGF) and three of its receptors, VEGFR-2, neuropilin-1, and neuropilin-2, in paraffin-embedded samples from 21 vestibular schwannomas associated with neurofibromatosis type 2 and from 22 sporadic schwannomas.	Paraffin	163-171	vascular endothelial growth factor A	Homo sapiens	85-89
19575783-8	2009	HER2 status was examined by immunohistochemical analysis of paraffin-embedded specimens.	Paraffin	60-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
19567385-4	2009	MATERIALS AND METHODS: The expression of cyclin A and E was investigated in the paraffin-embedded tumor tissue of 71 patients (53 men and 18 women; age 59.27+/-8.50 years), using a monoclonal antibodies to cyclin A and to cyclin E. RESULTS: Forty-seven out of 71 (66%) tumor tissue specimens were positive for cyclin A and twenty-six (37%) were positive for cyclin E. In the majority of cases, nuclear staining was apparent.	Paraffin	80-88	cyclin A2	Homo sapiens	41-49
19513552-7	2009	HER2 protein levels directly correlated with FoxM1 expression in both breast carcinoma cell lines and paraffin-embedded breast cancer patient samples.	Paraffin	102-110	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
19574774-2	2009	Epithelial cell adhesion molecule expression was evaluated by real-time polymerase chain reaction and immunohistochemistry in 168 fresh-frozen biopsies and paraffin-embedded tissues.	Paraffin	156-164	epithelial cell adhesion molecule	Homo sapiens	0-33
19494791-3	2009	NQO1 protein levels were immunohistochemically determined in formalin-fixed paraffin-embedded tissues.	Paraffin	76-84	NAD(P)H quinone dehydrogenase 1	Homo sapiens	0-4
19513505-9	2009	Using immunohistochemistry and immunofluorescence to examine the expression of FOXO1 in 185 surgically resected, paraffin-embedded stage I-IV tumor samples, we observed a significant correspondence between positive staining for FOXO1 in early stage tumors and in tumors without nodal involvement; in contrast, no significant relationship was observed between FOXO1 expression and tumor status, lymphatic invasion, or venous invasion.	Paraffin	113-121	forkhead box O1	Homo sapiens	79-84
19317849-3	2009	We analysed EGFR expression using immunohistochemistry on formalin-fixed, paraffin embedded surgical specimens of all patients.	Paraffin	74-82	epidermal growth factor receptor	Homo sapiens	12-16
19650989-5	2009	METHODS: p53 gene and chromosome 13q14 expression in paraffin sections of 30 cases of primary intestinal lymphoma and 10 cases of lymph node reactive hyperplasia were ascertained using an improved FISH technique.	Paraffin	53-61	tumor protein p53	Homo sapiens	9-12
19306859-8	2009	Applying immunohistochemistry, we further validated alpha1-AT immunoreactivity in 51 formalin-fixed paraffin-embedded sections of breast tumors.	Paraffin	100-108	serpin family A member 1	Homo sapiens	52-61
19428110-3	2009	We investigated HLA-A expression in 165 paraffin embedded tissues and 21 fresh tissues from liver cancer patients.	Paraffin	40-48	major histocompatibility complex, class I, A	Homo sapiens	16-21
19552806-11	2009	CONCLUSION: We have generated a novel, highly-specific monoclonal antibody that detects RAI3 in formaldehyde-fixed paraffin-embedded tissue.	Paraffin	115-123	G protein-coupled receptor class C group 5 member A	Homo sapiens	88-92
19428110-5	2009	54% of the paraffin embedded tissues showed increased HLA-A expression in their cancerous part.	Paraffin	11-19	major histocompatibility complex, class I, A	Homo sapiens	54-59
19509244-3	2009	We determined the expression of epidermal growth factor receptor (EGFR) and activated mammalian target of rapamycin (p-mTOR) in paraffin-embedded surgical specimens of BTA (n = 89) by immunohistochemistry.	Paraffin	128-136	epidermal growth factor receptor	Homo sapiens	32-64
19575985-3	2009	The expression of hypoxia inducible factor 1 alpha (HIF-1alpha) was examined by immunohistochemical staining in 42 cases of formalin-fixed paraffin-embed squamous cell carcinoma.	Paraffin	139-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-50
19509244-3	2009	We determined the expression of epidermal growth factor receptor (EGFR) and activated mammalian target of rapamycin (p-mTOR) in paraffin-embedded surgical specimens of BTA (n = 89) by immunohistochemistry.	Paraffin	128-136	mechanistic target of rapamycin kinase	Homo sapiens	119-123
19442604-8	2009	Immunohistochemistry confirmed the presence of MMP-1 and MMP-13 in paraffin-embedded GCT tissue samples.	Paraffin	67-75	matrix metallopeptidase 13	Homo sapiens	57-63
19243385-9	2009	Moreover, immunohistochemistry on paraffin-embedded tissue revealed that c-FLIP(L) was expressed in 87.9% (29 of 33) of lung carcinoma tissues from the patients, but little in tissues from normal controls.	Paraffin	34-42	CASP8 and FADD like apoptosis regulator	Homo sapiens	73-79
19157508-2	2009	The expression of epithelial cell adhesion molecule and E-cadherin was examined immunohistochemically on a tissue microarray of formalin-fixed paraffin-embedded tissue specimens from 72 consecutive patients.	Paraffin	143-151	epithelial cell adhesion molecule	Homo sapiens	18-51
19485944-3	2009	Immunohistochemistry was used to determine the expression of TIMP-1 on 38 paraffin-embedded breast tissue specimens - 18 with invasive ductal carcinoma, 10 with invasive lobular carcinoma, and 10 specimens from patients with fibrocystic breast disease.	Paraffin	74-82	TIMP metallopeptidase inhibitor 1	Homo sapiens	61-67
19304953-4	2009	Immunohistochemical analysis revealed that 80 of 168 (47.6%) paraffin-embedded archival ESCC specimens exhibited high levels of AEG-1 expression.	Paraffin	61-69	metadherin	Homo sapiens	128-133
19322590-7	2009	These findings suggest that HuC/D-S100beta-immunostained paraffin cross sections of human colon can be regarded as valuable tools for the quantitative estimation of myenteric neurons and glial cells.	Paraffin	57-65	ELAV like RNA binding protein 3	Homo sapiens	28-31
19322590-7	2009	These findings suggest that HuC/D-S100beta-immunostained paraffin cross sections of human colon can be regarded as valuable tools for the quantitative estimation of myenteric neurons and glial cells.	Paraffin	57-65	S100 calcium binding protein B	Homo sapiens	34-42
19575985-3	2009	The expression of hypoxia inducible factor 1 alpha (HIF-1alpha) was examined by immunohistochemical staining in 42 cases of formalin-fixed paraffin-embed squamous cell carcinoma.	Paraffin	139-147	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
18989634-3	2009	We defined P53 overexpression through immunohistochemistry of paraffin-embedded tumor tissues, using cutpoints based on percent of cells positive.	Paraffin	62-70	tumor protein p53	Homo sapiens	11-14
19101992-3	2009	Immunohistochemical analysis revealed overexpression of PRL-3 in 97 of 174 (55.7%) paraffin-embedded archival NPC biopsies.	Paraffin	83-91	protein tyrosine phosphatase 4A3	Homo sapiens	56-61
19289615-4	2009	PATIENTS AND METHODS: Immunohistochemical expression of p16(INK4A) was analyzed in pretreatment paraffin-embedded tumor blocks from 156 patients treated with conventional primary radiotherapy alone.	Paraffin	96-104	cyclin dependent kinase inhibitor 2A	Homo sapiens	56-59
19289615-4	2009	PATIENTS AND METHODS: Immunohistochemical expression of p16(INK4A) was analyzed in pretreatment paraffin-embedded tumor blocks from 156 patients treated with conventional primary radiotherapy alone.	Paraffin	96-104	cyclin dependent kinase inhibitor 2A	Homo sapiens	60-65
19100628-0	2009	Pax5 immunostaining in paraffin-embedded sections of canine non-Hodgkin lymphoma: a novel canine pan pre-B- and B-cell marker.	Paraffin	23-31	paired box 5	Canis lupus familiaris	0-4
19431122-0	2009	Her-2/neu gene amplification in paraffin-embedded tissue sections of meningioma patients.	Paraffin	32-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-9
19178934-3	2009	Immunohistochemical staining was performed to assess ER and PR expression in paraffin-embedded ovarian cancers.	Paraffin	77-85	estrogen receptor 1	Homo sapiens	53-55
20076883-2	2009	METHODS: The immunohistochemical expression of Her-2/Neu was studied in 37 formalin-fixed paraffin-embedded tissue sections.	Paraffin	90-98	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-56
19131554-4	2009	Using immunohistology with a new epitope retrieval technique for paraffin-embedded tissues, ED-B FN expression was found in biopsies from more than 200 Hodgkin and non-Hodgkin lymphoma patients of nearly all entities, and in patients with myeloproliferative diseases.	Paraffin	65-73	fibronectin 1	Homo sapiens	92-96
19411751-2	2009	METHODS: EnVisionTM immunohistochemistry was used for detecting the expression of VHL and HIF-1alpha in routinely paraffin-embedded sections from the specimens of lung cancer (n=80) and normal lung tissues (n=20).	Paraffin	114-122	hypoxia inducible factor 1 subunit alpha	Homo sapiens	90-100
19322925-2	2009	METHODS: PRL-3 expression in paraffin-embedded tumor specimens from 293 patients with gastric cancer was studied retrospectively by immunohistochemistry.	Paraffin	29-37	protein tyrosine phosphatase 4A3	Homo sapiens	9-14
19521280-5	2009	Paraffin immunohistochemistry showed finely granular cytoplasmic ALK1 expression, positive CD138, IgA, p63 (VS38), focal positive epithelial membrane antigen and CD4, and lambda light chain restriction whereas negative CD20 and CD30 staining.	Paraffin	0-8	CD4 molecule	Homo sapiens	162-165
19365965-0	2009	Biomarker p16(INK4a) on paraffin sections prepared from cervical brush samples highlights nuclear changes resulting in unquestionable cytohistodiagnosis.	Paraffin	24-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	10-13
19365965-0	2009	Biomarker p16(INK4a) on paraffin sections prepared from cervical brush samples highlights nuclear changes resulting in unquestionable cytohistodiagnosis.	Paraffin	24-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	14-19
19365965-10	2009	CONCLUSION: Cervical brush samples allow an unequivocal cytohistodiagnosis based on the (pre)malignant nuclear changes highlighted by the p16 staining of the paraffin sections.	Paraffin	158-166	cyclin dependent kinase inhibitor 2A	Homo sapiens	138-141
19365985-0	2009	Biomarker p16(INK4a) on paraffin sections from residual material: cancerous tissue fragments overlooked in false negative papanicolaou-stained thin-layer slide.	Paraffin	24-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	10-13
19365985-0	2009	Biomarker p16(INK4a) on paraffin sections from residual material: cancerous tissue fragments overlooked in false negative papanicolaou-stained thin-layer slide.	Paraffin	24-32	cyclin dependent kinase inhibitor 2A	Homo sapiens	14-19
19521280-5	2009	Paraffin immunohistochemistry showed finely granular cytoplasmic ALK1 expression, positive CD138, IgA, p63 (VS38), focal positive epithelial membrane antigen and CD4, and lambda light chain restriction whereas negative CD20 and CD30 staining.	Paraffin	0-8	keratin 20	Homo sapiens	219-223
19225135-4	2009	We developed a single-tube multiplex TaqMan (mERPR+HER2) assay to quantitate mRNA levels of ER, PR, HER2, and two housekeeping genes for breast cancer formalin-fixed, paraffin-embedded sections.	Paraffin	167-175	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-55
19063875-3	2009	We attempted to establish a new method for the detection of EGFR gene mutations with the use of paraffin-embedded samples.	Paraffin	96-104	epidermal growth factor receptor	Homo sapiens	60-64
19214113-0	2009	A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue.	Paraffin	172-180	epidermal growth factor receptor	Homo sapiens	93-97
19214113-0	2009	A novel proximity assay for the detection of proteins and protein complexes: quantitation of HER1 and HER2 total protein expression and homodimerization in formalin-fixed, paraffin-embedded cell lines and breast cancer tissue.	Paraffin	172-180	erb-b2 receptor tyrosine kinase 2	Homo sapiens	102-106
19138840-9	2009	Comparison of immunohistochemical staining on frozen sections and paraffin sections showed a reasonable concordance in Akt and BAD immunoreactivity.	Paraffin	66-74	AKT serine/threonine kinase 1	Homo sapiens	119-122
19212684-5	2009	Using tissue microarray of samples from 47 paraffin-embedded osteosarcoma cases, 26, 17, 20 and 12 cases showed positive immunostaining of EGFR, Stat-3, survivin and Erk, respectively.	Paraffin	43-51	epidermal growth factor receptor	Homo sapiens	139-143
19225135-4	2009	We developed a single-tube multiplex TaqMan (mERPR+HER2) assay to quantitate mRNA levels of ER, PR, HER2, and two housekeeping genes for breast cancer formalin-fixed, paraffin-embedded sections.	Paraffin	167-175	estrogen receptor 1	Homo sapiens	46-48
19188148-4	2009	EXPERIMENTAL DESIGN: We examined, by immunohistochemistry, FlnA localization in paraffin-embedded human prostate tissue representing different stages of progression.	Paraffin	80-88	filamin A	Homo sapiens	59-63
18988640-2	2009	Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR.	Paraffin	84-92	paired box 3	Homo sapiens	31-35
18988640-2	2009	Here, the authors detected the PAX3/7-FKHR fusion transcripts in 17 formalin-fixed, paraffin-embedded RMSs and 26 other SRCTs using one-step RT-PCR.	Paraffin	84-92	forkhead box O1	Homo sapiens	38-42
19096907-6	2009	This study was designed to evaluate the efficacy of different fixatives, of microwaving and microwave pretreatment method to retrieve p53 immunoreactivity in paraffin-embedded non-lesioned (adjacent normal tissue) human skin samples or pathological human skin samples diagnosed as basal cell carcinoma.	Paraffin	158-166	tumor protein p53	Homo sapiens	134-137
19082477-4	2009	We also performed immunohistochemical analysis of the expression of hMena protein in 50 cases of paraffin-embedded archival colorectal tissues, and found that an elevated hMena expression is correlated to the cases with advanced TNM stages of colorectal carcinomas (P&lt;0.001).	Paraffin	97-105	ENAH actin regulator	Homo sapiens	68-73
18815565-2	2009	Tumor tissues are formalin fixed and paraffin embedded (FFPE) for histopathologic evaluation, making the development of an antibody against c-MET that accurately and reproducibly detects the protein in FFPE samples an urgent need.	Paraffin	37-45	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	140-145
19697624-3	2009	METHODS: The expression of ERBB2 has been analyzed immunohistochemically in formalin-fixed paraffin-embedded primary uterine sarcomas (n = 11).	Paraffin	91-99	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-32
20797332-3	2008	METHODS: Immunohistochemical method was used to detect the heparanase expression in the routinely paraffin-embedded sections of surgical specimen of 66 cases with NSCLC and 15 ones with normal lung tissues.	Paraffin	98-106	heparanase	Homo sapiens	59-69
19489222-3	2009	METHODS: HER2 overexpression on paraffin sections from thirty-seven cases of breast invasive ductal carcinoma was evaluated using CB11 and the evaluation procedure had been repeated for five times scored the tests together according to the HercepTest and new American Society of Clinical Oncology/College of American Pathologists (ASCO/CAP) grading schemes by 2 experienced pathologists together.	Paraffin	32-40	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
18660793-6	2009	Immunostaining for epidermal growth factor receptor (EGFR) was performed on paraffin-embedded tissue sections containing tumor from these specimens, using the avidin-biotin-peroxidase method.	Paraffin	76-84	epidermal growth factor receptor	Homo sapiens	53-57
18544678-0	2008	Gene expression predicts overall survival in paraffin-embedded tissues of diffuse large B-cell lymphoma treated with R-CHOP.	Paraffin	45-53	DNA damage inducible transcript 3	Homo sapiens	119-123
19087271-5	2008	C-erbB2 gene expression was analyzed in 30 different human tissue samples of primary invasive breast cancer, following formalin fixation and subsequent paraffin-embedding.	Paraffin	152-160	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-7
18382348-1	2008	Detection of the tumor-specific fusion gene, FUS-CREB3L2, is useful in the diagnosis of low-grade fibromyxoid sarcoma (LGFMS), especially by reverse transcription (RT)-polymerase chain reaction (PCR) using formalin-fixed, paraffin-embedded (FFPE) tumor tissues.	Paraffin	222-230	FUS RNA binding protein	Homo sapiens	45-48
18984785-4	2008	COX-2 expression was assessed in formalin-fixed paraffin-embedded tissues from 14 sarcoids, 11 melanomas, and 37 SCC that represent various anatomic sites by using standard immunohistochemical methods.	Paraffin	48-56	prostaglandin-endoperoxide synthase 2	Equus caballus	0-5
18382348-0	2008	DNA-based polymerase chain reaction for detecting FUS-CREB3L2 in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens.	Paraffin	117-125	FUS RNA binding protein	Homo sapiens	50-53
18787015-9	2008	CONCLUSIONS: Our data indicate that this PCR-free L-FISH method can be used to evaluate ERBB2 amplification in both cell-containing (paraffin-embedded tissue) and cell-free (serum) samples.	Paraffin	133-141	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-93
18949419-7	2008	The expression of HIF-1alpha was measured in paraffin-embedded specimens from patients by immunohistochemistry.	Paraffin	45-53	hypoxia inducible factor 1 subunit alpha	Homo sapiens	18-28
18854030-5	2008	DNA was extracted after laser microdissection from the 181 paraffin-embedded HER2 amplified (n=39) or HER2 negative (n=142) tumor specimens with sufficient tumor available to perform molecular analysis.	Paraffin	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	77-81
18840722-0	2008	Blocks to paraffin get the CHOP, +R.	Paraffin	10-18	DNA damage inducible transcript 3	Homo sapiens	27-31
18700874-3	2008	In this study, we characterized a set of nine mAbs, developed against the C domain of human ACE, which recognize the denatured forms of ACE and thus are suitable for the detection and quantification of somatic ACE (sACE) and testicular ACE (tACE) using Western blotting and immunohistochemistry on paraffin-embedded human tissues.	Paraffin	298-306	angiotensin I converting enzyme	Homo sapiens	92-95
18847499-2	2008	METHODS: To this end, the expression of VEGF was analyzed by immunohistochemistry using paraffin-embedded pre-treatment cervical biopsy tissues.	Paraffin	88-96	vascular endothelial growth factor A	Homo sapiens	40-44
19256750-9	2008	Immunohistochemical analysis of p16INK4A was performed on 53 formalin fixed and paraffin embedded samples of various stages of cervical neoplastic lesions.	Paraffin	80-88	cyclin dependent kinase inhibitor 2A	Homo sapiens	32-40
18971621-1	2008	BACKGROUND: FISH and immunohistochemistry (IHC) on formalin-fixed paraffin embedded (FFPE) tissue are currently used in the clinical laboratory to determine HER2 status in invasive breast cancer patients.	Paraffin	66-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	157-161
18587329-5	2008	E-cadherin staining was conducted on the paraffin-embedded sections of the breast lesions using two different source antibodies.	Paraffin	41-49	cadherin 1	Homo sapiens	0-10
18852138-4	2008	Immunohistochemistry of paraffin-embedded human tissue shows that ATX levels are markedly increased in human primary and metastatic melanoma relative to benign nevi.	Paraffin	24-32	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	66-69
18813308-4	2008	TROP2 antigen expression was investigated retrospectively by immunohistochemistry in paraffin-embedded primary tumour tissue samples from a series (n=197) of consecutive patients with pancreatic adenocarcinoma.	Paraffin	85-93	tumor associated calcium signal transducer 2	Homo sapiens	0-5
18760195-9	2008	METHODS: Expression of p16 in ten samples of Iranian paraffin-embedded skin BCC were studied using in situ RT-PCR and immunohistochemistry on p16INK4a gene.	Paraffin	53-61	cyclin dependent kinase inhibitor 2A	Homo sapiens	23-26
18854653-3	2008	PATIENTS AND METHODS: Here, using immunohistochemistry, we analyzed the levels of alpha V integrins and VEGF in paraffin sections of 20 patients with untreated osteosarcoma, and 31 patients with adriamycin/cisplatin/ifosfamide-treated osteosarcoma.	Paraffin	112-120	vascular endothelial growth factor A	Homo sapiens	104-108
18700874-3	2008	In this study, we characterized a set of nine mAbs, developed against the C domain of human ACE, which recognize the denatured forms of ACE and thus are suitable for the detection and quantification of somatic ACE (sACE) and testicular ACE (tACE) using Western blotting and immunohistochemistry on paraffin-embedded human tissues.	Paraffin	298-306	angiotensin I converting enzyme	Homo sapiens	136-139
18700874-3	2008	In this study, we characterized a set of nine mAbs, developed against the C domain of human ACE, which recognize the denatured forms of ACE and thus are suitable for the detection and quantification of somatic ACE (sACE) and testicular ACE (tACE) using Western blotting and immunohistochemistry on paraffin-embedded human tissues.	Paraffin	298-306	angiotensin I converting enzyme	Homo sapiens	136-139
18700874-3	2008	In this study, we characterized a set of nine mAbs, developed against the C domain of human ACE, which recognize the denatured forms of ACE and thus are suitable for the detection and quantification of somatic ACE (sACE) and testicular ACE (tACE) using Western blotting and immunohistochemistry on paraffin-embedded human tissues.	Paraffin	298-306	angiotensin I converting enzyme	Homo sapiens	136-139
18700874-8	2008	Their high reactivity in paraffin-embedded tissues provides opportunities to study changes in the pattern of ACE expression and glycosylation (particularly with mAb 5B9) in different tissues and cells.	Paraffin	25-33	angiotensin I converting enzyme	Homo sapiens	109-112
19031942-2	2008	MATERIALS AND METHODS: Activated (phosphorylated) p38-MAPK was immunohistochemically assessed in paraffin-embedded tumors obtained at primary debulking surgery from 45 patients treated with gemcitabine for platinum-resistant recurrence.	Paraffin	97-105	mitogen-activated protein kinase 14	Homo sapiens	50-53
18837891-5	2008	The present study was designed to evaluate Bcl-2 protein expression in breast tumor paraffin-embedded fixed tissue and sought to investigate association with the Bcl-2 protein release in patient serum, as well as its relationship with clinicopathological features.	Paraffin	84-92	BCL2 apoptosis regulator	Homo sapiens	43-48
18720326-7	2008	The positive detection of the SYT-SSX1 fusion transcripts with reverse-transcription polymerase chain reaction in formalin-fixed and paraffin-embedded tissue confirmed the synovial sarcoma diagnosis.	Paraffin	133-141	SSX family member 1	Homo sapiens	34-38
18021217-3	2008	MGB-2 expression was evaluated by real-time polymerase chain reaction (PCR) and immunohistochemistry (IHC) in fresh frozen biopsies and paraffin-embedded tissues derived from a total of 70 patients including 50 primary EEC and 20 normal endometria (NECs).	Paraffin	136-144	secretoglobin family 2A member 1	Homo sapiens	0-5
18619459-3	2008	METHODS: We immunohistochemically assayed p53 expression in paraffin-fixed colon cancer specimens in a large prospective cohort of women with 22 years of follow-up to examine the relationship of folate intake and intake of other one-carbon nutrients to risks by tumor p53 expression.	Paraffin	60-68	tumor protein p53	Homo sapiens	42-45
20735955-4	2008	METHODS: The expression of BAG-1 was detected by real-time PCR in formalin-fixed, paraffin-embedded human lung cancer tissues of 156 cases.	Paraffin	82-90	BAG cochaperone 1	Homo sapiens	27-32
18355177-7	2008	CONCLUSION: Chromogenic double staining of CD4/FoxP3 is a promising tool for the detection of Treg in paraffin-embedded tissue of OSCC.	Paraffin	102-110	CD4 molecule	Homo sapiens	43-46
18705844-4	2008	The expression of Bcl-2 and Bax was assessed by immunochemistry on paraffin-embedded placental specimens.	Paraffin	67-75	BCL2 apoptosis regulator	Homo sapiens	18-23
18705844-4	2008	The expression of Bcl-2 and Bax was assessed by immunochemistry on paraffin-embedded placental specimens.	Paraffin	67-75	BCL2 associated X, apoptosis regulator	Homo sapiens	28-31
18440293-0	2008	GSTT1 and GSTM1 gene copy number analysis in paraffin-embedded tissue using quantitative real-time PCR.	Paraffin	45-53	glutathione S-transferase mu 1	Homo sapiens	10-15
18474542-5	2008	METHODS: The expression of p-mTOR (Ser2448) was immunohistochemically assessed in a validated tissue microarray comprising triplicate tissue biopsy cores of 108 formalin-fixed, paraffin-embedded OSCCs.	Paraffin	177-185	mechanistic target of rapamycin kinase	Homo sapiens	27-33
18330889-2	2008	We examined, for the first time, 196 paraffin-embedded CRC cases from Northern Iran for mutations in P53 exons 5-8 using PCR-direct sequencing.	Paraffin	37-45	tumor protein p53	Homo sapiens	101-104
18554951-2	2008	STUDY DESIGN: Streptavidin peroxidase immunohistochemical staining was used to detect the expression of HIF-1alpha and CD34 in paraffin-embedded samples from 25 patients.	Paraffin	127-135	hypoxia inducible factor 1 subunit alpha	Homo sapiens	104-114
18554951-2	2008	STUDY DESIGN: Streptavidin peroxidase immunohistochemical staining was used to detect the expression of HIF-1alpha and CD34 in paraffin-embedded samples from 25 patients.	Paraffin	127-135	CD34 molecule	Homo sapiens	119-123
18780655-1	2008	AIM: To examine by means of immunohistochemistry the expression of the tumor suppressing gene p53 and gene p21 in cells of malignant melanoma of the uvea from formalin-paraffin material from patients, who were during the period 2000 - 2006 surgically treated due to malignant melanoma of the uvea at the Department of Ophthalmology in the University Hospital in Brno (Brunn), Czech Republic, E.U., and to correlate the results of the immunohistochemical detection with clinical signs of the tumor of each patient.	Paraffin	168-176	tumor protein p53	Homo sapiens	94-97
18371184-5	2008	Therefore, we investigated WT1 expression in paraffin-embedded brain sections from 28 controls, 48 cases with astrogliosis of various etiology and 219 astrocytomas [World Health Organization (WHO) grades I-IV] by immunohistochemistry.	Paraffin	45-53	WT1 transcription factor	Homo sapiens	27-30
18705836-3	2008	The diagnosis of alveolar rhabdomyosarcoma was confirmed by the detection of PAX3-FKHR fusion gene transcripts in the paraffin-embedded tumor tissue.	Paraffin	118-126	forkhead box O1	Homo sapiens	82-86
18479731-12	2008	Because the anti-PD-1.6.4 antibody works on paraffin sections, it represents a useful tool to differentiate SLL/CLL from other small B-cell lymphomas.	Paraffin	44-52	programmed cell death 1	Mus musculus	17-21
18667776-2	2008	METHODS: EnVision immunohistochemical method was used to detect the expressive levels of EZH2 and PTEN in routinely paraffin-embedded sections in the resected specimens of gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp(n = 15), and chronic cholecystitis (n = 35).	Paraffin	116-124	enhancer of zeste 2 polycomb repressive complex 2 subunit	Homo sapiens	89-93
18705836-3	2008	The diagnosis of alveolar rhabdomyosarcoma was confirmed by the detection of PAX3-FKHR fusion gene transcripts in the paraffin-embedded tumor tissue.	Paraffin	118-126	paired box 3	Homo sapiens	77-81
18400268-2	2008	METHODS: We performed immunohistochemistry for COX-2 on paraffin-embedded tumors of UCUUT specimens from 79 patients.	Paraffin	56-64	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	47-52
18516290-10	2008	In addition, Pyrosequencing is useful in detecting PIK3CA mutation in archival paraffin tumor tissue.	Paraffin	79-87	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	51-57
18445689-0	2008	Paraffin-based 6-gene model predicts outcome in diffuse large B-cell lymphoma patients treated with R-CHOP.	Paraffin	0-8	DNA damage inducible transcript 3	Homo sapiens	102-106
18445689-5	2008	Herein, we evaluated the predictive power of a paraffin-based 6-gene model in R-CHOP-treated DLBCL patients.	Paraffin	47-55	DNA damage inducible transcript 3	Homo sapiens	80-84
18519759-8	2008	Immunohistochemical analysis revealed high expression of AEG-1 in 100 of 225 (44.4%) paraffin-embedded archival breast cancer biopsies.	Paraffin	85-93	metadherin	Homo sapiens	57-62
18366005-4	2008	METHODS: This paper investigated, for the first time, claudin-2 expression in the pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy.	Paraffin	95-103	claudin 2	Homo sapiens	54-63
18474293-0	2008	Detection of the TMPRSS2-ETS fusion gene in prostate carcinomas: retrospective analysis of 55 formalin-fixed and paraffin-embedded samples with clinical data.	Paraffin	113-121	transmembrane serine protease 2	Homo sapiens	17-24
18223028-8	2008	In paraffin sections of atrial appendage tissue, we observed a distinct staining pattern for ACE2 which appeared different from that of ACE.	Paraffin	3-11	angiotensin I converting enzyme	Homo sapiens	93-96
18348286-2	2008	We have developed a high-throughput scanning assay with automatic calling to detect TP53 mutations in DNA from fresh frozen (FF) and formalin-fixed paraffin-embedded (FFPE) tissues.	Paraffin	148-156	tumor protein p53	Homo sapiens	84-88
18221322-6	2008	LOH in paraffin-embedded specimens was detected in 22.6% and 12.9% for FHIT and p53 respectively.	Paraffin	7-15	tumor protein p53	Homo sapiens	80-83
18172859-5	2008	We also evaluated the expression of MMP-9 and TIMP-1 protein and mRNA in paraffin-embedded tumor tissues from the 60 breast cancer patients by immunohistochemistry and in situ hybridization.	Paraffin	73-81	TIMP metallopeptidase inhibitor 1	Homo sapiens	46-52
18452136-2	2008	In this study high-quality CdSe QDs prepared in a paraffin-oleic acid system were used as fluorescent labels in direct and indirect detection of carcinoembryonic antigen (CEA), a cancer marker expressed on the surface of HeLa cells.	Paraffin	50-58	CEA cell adhesion molecule 3	Homo sapiens	145-169
18452136-2	2008	In this study high-quality CdSe QDs prepared in a paraffin-oleic acid system were used as fluorescent labels in direct and indirect detection of carcinoembryonic antigen (CEA), a cancer marker expressed on the surface of HeLa cells.	Paraffin	50-58	CEA cell adhesion molecule 3	Homo sapiens	171-174
18306351-1	2008	BACKGROUND: Fluorescence in situ hybridization (FISH) is the gold standard for assessing HER-2 status for breast cancers, and paraffin-embedded tissue sections are used routinely for HER-2 FISH.	Paraffin	126-134	erb-b2 receptor tyrosine kinase 2	Homo sapiens	183-188
18204431-7	2008	A monoclonal antibody against PPAR-gamma was used to stain formalin-fixed paraffin-embedded tissue.	Paraffin	74-82	peroxisome proliferator activated receptor gamma	Homo sapiens	30-40
18395914-3	2008	Experimental hepatic fibrosis was induced by subcutaneous injection of carbon tetrachloride (CCl4 soluted in liquid paraffin with the concentration of 300 g/L, the dosage of injection was 3 mL/kg, twice per week for 8 wk).	Paraffin	116-124	C-C motif chemokine ligand 4	Rattus norvegicus	93-97
18395906-5	2008	p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections.	Paraffin	71-79	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
17919838-5	2008	COX-2 expression was assessed immunohistochemically using a mouse monoclonal antibody on formalin-fixed paraffin-embedded tumor specimens taken before RT.	Paraffin	104-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
18646324-3	2008	DNA from tumor tissue extracted from the paraffin sections was used as template for amplification of the E-cadherin gene exonic regions.	Paraffin	41-49	cadherin 1	Homo sapiens	105-115
18234280-4	2008	Immunoreactivity of p16(INK4) was investigated using paraffin sections from 8 different sample groups (n = 80), including organ donor bladders with normal and/or reactive urothelium; bladder biopsies with reactive atypia; isolated carcinoma in situ; high-grade UC with concurrent carcinoma in situ; low-grade papillary urothelial neoplasms; high-grade stage T1 UC; and high-grade stage T2-T4 UC without concomitant carcinoma in situ.	Paraffin	53-61	cyclin dependent kinase inhibitor 2A	Homo sapiens	20-23
18234280-4	2008	Immunoreactivity of p16(INK4) was investigated using paraffin sections from 8 different sample groups (n = 80), including organ donor bladders with normal and/or reactive urothelium; bladder biopsies with reactive atypia; isolated carcinoma in situ; high-grade UC with concurrent carcinoma in situ; low-grade papillary urothelial neoplasms; high-grade stage T1 UC; and high-grade stage T2-T4 UC without concomitant carcinoma in situ.	Paraffin	53-61	cyclin dependent kinase inhibitor 2A	Homo sapiens	24-28
18393238-3	2008	Immunohistochemical staining for P53 was performed on paraffin-embedded sections.	Paraffin	54-62	tumor protein p53	Homo sapiens	33-36
18507060-5	2008	Immunohistochemical reactions were performed for p53 staining in paraffin embedded histological sections of oral leukoplakia lesions.	Paraffin	65-73	tumor protein p53	Homo sapiens	49-52
18303411-0	2008	Detection of FOXO1 (FKHR) gene break-apart by fluorescence in situ hybridization in formalin-fixed, paraffin-embedded alveolar rhabdomyosarcomas and its clinicopathologic correlation.	Paraffin	100-108	forkhead box O1	Homo sapiens	13-18
18208813-0	2008	CD33 detection by immunohistochemistry in paraffin-embedded tissues: a new antibody shows excellent specificity and sensitivity for cells of myelomonocytic lineage.	Paraffin	42-50	CD33 molecule	Homo sapiens	0-4
18398703-3	2008	p53 and BCL-2 immunohistochemical expression was determined using paraffin blocks containing the tumor area.	Paraffin	66-74	BCL2 apoptosis regulator	Homo sapiens	8-13
18188593-3	2008	We conducted this study trying to elucidate the role of NFkappaB in bladder UC and its potential prognostic significance, by quantifying immunohistochemically the levels of p65/RelA expression in paraffin-embedded tissue from 116 patients.	Paraffin	196-204	nuclear factor kappa B subunit 1	Homo sapiens	56-64
18196271-2	2008	We investigated the impact of tissue injury by preoperative sampling on the level of uPA/PAI-1 in paraffin tissue of 55 breast cancer cases by immunohistochemistry.	Paraffin	98-106	plasminogen activator, urokinase	Homo sapiens	85-88
18208813-1	2008	A new monoclonal antibody to CD33 that reacts in paraffin-embedded tissue samples was evaluated.	Paraffin	49-57	CD33 molecule	Homo sapiens	29-33
18208813-6	2008	This anti-CD33 antibody will be a useful marker in the workup of acute leukemias and myeloid sarcomas on paraffin-embedded tissue samples.	Paraffin	105-113	CD33 molecule	Homo sapiens	10-14
18465327-7	2008	RESULTS AND CONCLUSION: IHC stainings for ER, PgR, and HER2 showed a substantial agreement between a single 1mm TMA core and the corresponding whole section, between central and peripheral cores, and between cores from two different paraffin blocks from the same tumor.	Paraffin	233-241	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-59
18026799-3	2008	METHODS: IEX-1 protein expression was examined on paraffin-embedded specimens from 78 patients with pancreatic ductal adenocarcinoma using immunohistochemistry.	Paraffin	50-58	immediate early response 3	Homo sapiens	9-14
18084248-6	2008	TROP2 expression was examined by immunohistochemistry in a series of 90 patients on a tissue microarray of paraffin-embedded specimens.	Paraffin	107-115	tumor associated calcium signal transducer 2	Homo sapiens	0-5
18210110-7	2008	Molecular analysis of AAT and HFE genes in paraffin-embedded tissue or blood can confirm the diagnosis and allows the zygosity status to be defined.	Paraffin	43-51	serpin family A member 1	Homo sapiens	22-25
18607961-5	2008	From these patients we chose 21 who had never smoked or drunk alcohol and performed immunohistochemical staining for p53 protein in paraffin-embedded archival blocks.	Paraffin	132-140	tumor protein p53	Homo sapiens	117-120
18592792-4	2008	METHODS: Expression of KIT was analyzed immunohistochemically (n = 12) in formalin-fixed paraffin-embedded primary uterine sarcomas.	Paraffin	89-97	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	23-26
18333330-12	2008	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Paraffin	117-125	SSX family member 1	Homo sapiens	156-161
18632221-4	2008	METHODS: Methylation-specific polymerase chain reaction (MSP) was performed to detect E-cadherin promoter hypermethylation in paraffin embedded tissues from patients with NPC and normal nasopharyngeal tissues.	Paraffin	126-134	cadherin 1	Homo sapiens	86-96
18071837-5	2008	We detected the expression of TTF-1 protein and messenger RNA (mRNA) in paraffin-embedded lung carcinomas and their normal lung tissues by tissue microarray.	Paraffin	72-80	NK2 homeobox 1	Homo sapiens	30-35
16775119-5	2008	METHODS: Ep-CAM expression was investigated retrospectively by immunohistochemistry in paraffin-embedded primary tumour tissue samples from a series of consecutive patients with pancreatic (n = 153) and ampullary cancer (n = 34).	Paraffin	87-95	epithelial cell adhesion molecule	Homo sapiens	9-15
17899426-3	2008	Immunohistochemical analysis for Her2/neu was done on paraffin-fixed tissues with CB11 antibodies (BioGenex, San Ramon, CA, USA).	Paraffin	54-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	33-41
17451461-3	2008	The aim of the present study was to evaluate HER-2 expression by immunohistochemistry (IHC) in 12 USPC formalin-fixed, paraffin-embedded (FFPE) samples.	Paraffin	119-127	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-50
18021371-6	2007	The modifications of in situ hybridization of mRNA phosphatase of regenerating liver-3 (PRL-3) methods are preformed in the study of paraffin-embedded slides.	Paraffin	133-141	protein tyrosine phosphatase 4A3	Homo sapiens	51-86
19082950-6	2008	In this chapter, we will describe a technique that provides a more reliable, much simpler approach for the demonstration of cyclooxygenase-1 and cyclooxygenase-2 expression in frozen, vibratome or paraffin sections, and/or cells in cultures.	Paraffin	197-205	prostaglandin-endoperoxide synthase 1	Homo sapiens	124-140
19082950-6	2008	In this chapter, we will describe a technique that provides a more reliable, much simpler approach for the demonstration of cyclooxygenase-1 and cyclooxygenase-2 expression in frozen, vibratome or paraffin sections, and/or cells in cultures.	Paraffin	197-205	prostaglandin-endoperoxide synthase 2	Homo sapiens	145-161
18227018-2	2008	METHODS: TTF-1 mRNA was detected using tissue microarray and in situ hybridization in 1320 different paraffin-embedded tissue specimens.	Paraffin	101-109	NK2 homeobox 1	Homo sapiens	9-14
17418618-2	2008	EpCAM expression was examined immunohistochemically on a tissue microarray (TMA) of paraffin embedded tissue specimens from 77 consecutive patients who underwent surgical treatment for squamous cell carcinoma of the oral cavity in the period between 1980 and 1997 at the Department of Craniomaxillofacial and Oral Surgery, Innsbruck Medical University.	Paraffin	84-92	epithelial cell adhesion molecule	Homo sapiens	0-5
18091380-3	2007	The overexpression of HER2 was studied on paraffin sections of 50 breast cancers using a polyclonal antibody assay (HercepTest) and monoclonal antibodies (clones SV2-61gamma and CB11).	Paraffin	42-50	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-26
19391487-2	2008	In this study we evaluated the immunohistochemical expression of AR in a series of 37 formalin-fixed, paraffin-embedded malignant salivary gland tumors using two commercially available antibodies.	Paraffin	102-110	androgen receptor	Homo sapiens	65-67
20103886-3	2007	In this study, the expression and distribution of phosphorylated ERK (p-ERK) in normal human skin and SCC with different degrees of differentiation was examined by immunohistochemical analysis using formalin-fixed paraffin embedded sections.	Paraffin	214-222	mitogen-activated protein kinase 1	Homo sapiens	65-68
20103886-3	2007	In this study, the expression and distribution of phosphorylated ERK (p-ERK) in normal human skin and SCC with different degrees of differentiation was examined by immunohistochemical analysis using formalin-fixed paraffin embedded sections.	Paraffin	214-222	mitogen-activated protein kinase 1	Homo sapiens	72-75
18048815-4	2007	MATERIALS AND METHODS: The complete coding region of the p53 gene was queried using DNA from paraffin-embedded tissues and employing a p53 gene-sequencing chip.	Paraffin	93-101	tumor protein p53	Homo sapiens	57-60
18021371-6	2007	The modifications of in situ hybridization of mRNA phosphatase of regenerating liver-3 (PRL-3) methods are preformed in the study of paraffin-embedded slides.	Paraffin	133-141	protein tyrosine phosphatase 4A3	Homo sapiens	88-93
17892529-4	2007	Immunohistochemistry performed on paraffin sections of the involuting mammary gland revealed IGFBP-5 positive staining of epithelial cells only outside the nucleus.	Paraffin	34-42	insulin like growth factor binding protein 5	Homo sapiens	93-100
17987122-5	2007	METHODOLOGY/PRINCIPAL FINDINGS: The HER2 status of primary tumors and metastases was evaluated by both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) analysis of paraffin-embedded tissue on conventional slides.	Paraffin	188-196	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-40
17824790-13	2007	CONCLUSIONS: Our results show that the real-time polymerase chain reaction method is a rapid and accurate method for identifying BRAF mutations, such as V600E, in both paraffin-embedded tissue and fine-needle aspirate specimens.	Paraffin	168-176	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	129-133
17968460-2	2007	METHODS: Using immunohistochemistry, we investigated the distribution of androgen receptor (AR) in the extragenital tissues of paraffin-embedded tissue sections of first trimester (8-12 weeks gestation) human embryos.	Paraffin	127-135	androgen receptor	Homo sapiens	73-90
17968460-2	2007	METHODS: Using immunohistochemistry, we investigated the distribution of androgen receptor (AR) in the extragenital tissues of paraffin-embedded tissue sections of first trimester (8-12 weeks gestation) human embryos.	Paraffin	127-135	androgen receptor	Homo sapiens	92-94
18055344-4	2007	BCL2 /IgH translocation was analyzed in paraffin-embedded tissues from follicular lymphoma patients by using polymerase chain reaction (PCR) analysis of the major breakpoint region (MBR), the intermediate cluster region (ICR), and the minor cluster region.	Paraffin	40-48	BCL2 apoptosis regulator	Homo sapiens	0-4
17590872-6	2007	The sequences of exon 1 of K-Ras and exons 9 and 20 of PIK3CA were determined by direct sequencing using genomic DNA extracted from paraffin-embedded blocks.	Paraffin	132-140	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha	Homo sapiens	55-61
17964965-18	2007	RT-PCR, using paraffin-embedded tissue sections, can effectively detect the characteristic EWS-WT1 fusion gene transcript.	Paraffin	14-22	WT1 transcription factor	Homo sapiens	91-98
17721270-1	2007	To clarify the significance of cdc25B, which plays an important physiologic role in regulation of the G2/M check point, in progression of gastric cancer, 125 samples of paraffin-embedded gastric cancers were investigated by immunohistochemistry.	Paraffin	169-177	cell division cycle 25B	Homo sapiens	31-37
18303625-6	2007	TNF-alpha proteins in paraffin-embedded lung sections were immunohistochemistrily stained on tissue microarray with PV method.	Paraffin	22-30	tumor necrosis factor	Rattus norvegicus	0-9
17882246-0	2007	Immunofluorescence on proteinase XXIV-digested paraffin sections.	Paraffin	47-55	endogenous retrovirus group K member 25	Homo sapiens	22-32
17721195-11	2007	In conclusion, FUS-CREB3L1/L2 fusion transcripts can be detected in paraffin-embedded LGFMS in a sensitive manner, using reverse transcription-polymerase chain reaction.	Paraffin	68-76	FUS RNA binding protein	Homo sapiens	15-18
17542985-2	2007	PATIENTS, MATERIALS AND METHODS: The expression and activation of the cell survival protein Akt was analysed by immunohistochemical staining of paraffin-embedded tissue microarray sections of prostate carcinoma taken from 52 Japanese men who under radical prostatectomy.	Paraffin	144-152	AKT serine/threonine kinase 1	Homo sapiens	92-95
17555500-0	2007	Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas.	Paraffin	54-62	menin 1	Homo sapiens	18-22
17597495-7	2007	Second, ribonuclease protection assay on paraffin-embedded specimens showed overexpression of PAR-1 and PAR-2 mRNA in K compared to NS and HS.	Paraffin	41-49	coagulation factor II thrombin receptor	Homo sapiens	94-99
17354029-4	2007	METHODS: The expression of VEGF-C was evaluated using immunohistochemistry (IHC) on 59 paraffin-embedded archival specimens from patients with squamous cell esophageal carcinomas and 54 paraffin-embedded archival specimens of patients with esophageal adenocarcinomas arising in Barrett"s mucosa.	Paraffin	87-95	vascular endothelial growth factor C	Homo sapiens	27-33
17354029-4	2007	METHODS: The expression of VEGF-C was evaluated using immunohistochemistry (IHC) on 59 paraffin-embedded archival specimens from patients with squamous cell esophageal carcinomas and 54 paraffin-embedded archival specimens of patients with esophageal adenocarcinomas arising in Barrett"s mucosa.	Paraffin	186-194	vascular endothelial growth factor C	Homo sapiens	27-33
17699857-4	2007	EXPERIMENTAL DESIGN: We determined expression of p-mTOR in paraffin-embedded surgical specimens of BTA by immunohistochemistry with a monoclonal antibody to phosphorylated mTOR.	Paraffin	59-67	mechanistic target of rapamycin kinase	Homo sapiens	49-55
17699857-4	2007	EXPERIMENTAL DESIGN: We determined expression of p-mTOR in paraffin-embedded surgical specimens of BTA by immunohistochemistry with a monoclonal antibody to phosphorylated mTOR.	Paraffin	59-67	mechanistic target of rapamycin kinase	Homo sapiens	51-55
17640856-1	2007	BACKGROUND AND OBJECTIVES: In the present paper we report that SAP, an intracytoplasmic molecule that is involved in cell signaling, is an immunohistologic marker for germinal center T cells in paraffin-embedded tissue.	Paraffin	194-202	amyloid P component, serum	Sus scrofa	63-66
17640856-3	2007	DESIGN AND METHODS: Expression of SAP and PD-1 was investigated by immunohistochemistry in paraffin-embedded tissue sections and in cell lines.	Paraffin	91-99	amyloid P component, serum	Sus scrofa	34-37
17605082-5	2007	We show herein the unequivocal identification of oval cells in paraffin-embedded mouse liver samples based on strong E-cadherin expression different from that of hepatocytes and bile duct cells.	Paraffin	63-71	cadherin 1	Mus musculus	117-127
17367324-4	2007	p16(INK4a) expression was analyzed in paraffin-embedded sections using immunohistochemical staining.	Paraffin	38-46	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
17341475-1	2007	This study identifies the actin-binding protein, coronin-1a, as a novel and effective immunohistochemical marker for microglia in both cell cultures and in formaldehyde-fixed, paraffin-embedded tissue.	Paraffin	176-184	coronin 1A	Homo sapiens	49-59
17634528-3	2007	EXPERIMENTAL DESIGN: Expression of ER alpha and ER beta were examined using an immunohistochemical methods in 73 paraffin-embedded sections collected from patients with ESCC who had been subjected to esophageal resection and digestive reconstruction without any preoperative induction therapy.	Paraffin	113-121	estrogen receptor 1	Homo sapiens	35-43
17587181-3	2007	The HER2 status was determined using both immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) in the paraffin-embedded surgical specimens after neoadjuvant chemotherapy.	Paraffin	122-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	4-8
17606720-7	2007	METHODS AND RESULTS: Immunohistochemical expression of Prx1 and Nrf2 was evaluated in paraffin-embedded tissues from 90 patients who underwent a curative surgical resection.	Paraffin	86-94	NFE2 like bZIP transcription factor 2	Homo sapiens	64-68
17636064-3	2007	METHODS: tPA and von Willebrand factor (vWF), a vascular endothelial cell marker, are detected on vascular endothelium by immunoperoxidase methods with specific antibodies on formalin fixed paraffin embedded sural nerve biopsies from six diabetic and six axonal neuropathy control nerves without vasculopathy.	Paraffin	190-198	von Willebrand factor	Homo sapiens	17-38
17636064-3	2007	METHODS: tPA and von Willebrand factor (vWF), a vascular endothelial cell marker, are detected on vascular endothelium by immunoperoxidase methods with specific antibodies on formalin fixed paraffin embedded sural nerve biopsies from six diabetic and six axonal neuropathy control nerves without vasculopathy.	Paraffin	190-198	von Willebrand factor	Homo sapiens	40-43
18074738-4	2007	PATIENTS AND METHODS: Immunohistochemistry was performed, using a monoclonal antibody against bax, in paraffin-embedded tumor specimens from 47 cases of gastric cancer.	Paraffin	102-110	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
17442372-3	2007	Here, we studied the expression of pontin in 34 patients with histologically proven colorectal cancer by immunohistochemistry on paraffin-embedded colorectal cancer samples using the monoclonal mouse anti-pontin (5G3-11) antibody.	Paraffin	129-137	RuvB like AAA ATPase 1	Homo sapiens	35-41
17018686-2	2007	METHODS: c-kit expression was examined in 100 human osteosarcomas by immunohistochemistry using paraffin embedded tumour tissues, and capillary sequencing of genomic DNA was performed to search for mutations in exons 9 and 11 of the c-kit gene.	Paraffin	96-104	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-14
17492461-2	2007	hPLAP enzyme activity was retained during paraffin and methylmethacrylate (MMA) embedding, and was best preserved using 40% ethanol as fixative.	Paraffin	42-50	alkaline phosphatase, placental	Homo sapiens	0-5
17559647-4	2007	hPLAP is an excellent marker enzyme, providing superb histological detection quality in paraffin and plastic sections.	Paraffin	88-96	alkaline phosphatase, placental	Homo sapiens	0-5
17498596-9	2007	Both c-kit and CD34 antigen were positive with strong and diffuse stainability in smears as well as paraffin sections by immunoperoxidase staining.	Paraffin	100-108	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	5-10
17498596-9	2007	Both c-kit and CD34 antigen were positive with strong and diffuse stainability in smears as well as paraffin sections by immunoperoxidase staining.	Paraffin	100-108	CD34 molecule	Homo sapiens	15-19
17609359-5	2007	Cyclooxygenase-2 expression was found in 6 of 22 (27%) paraffin-embedded equine SCCs.	Paraffin	55-63	prostaglandin-endoperoxide synthase 2	Equus caballus	0-16
18069630-2	2007	METHODS: Methylation specific PCR (MSP) was used to examine the promoter methylation of tumor suppressor genes E-cadherin, hMLH1, APC and MGMT in paraffin-embedded gastric cancer tissue and adjacent normal foveolar epithelium in 106 cases.	Paraffin	146-154	cadherin 1	Homo sapiens	111-121
17594159-5	2007	Expression of COX-2 and p53 proteins was examined by immunohistochemistry in paraffin-embedded cancer tissue blocks, and the relationship between COX-2 and/or p53 expression with clinicopathologic parameters was analyzed.	Paraffin	77-85	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	14-19
17343903-3	2007	METHODS: Mammaglobin B expression was evaluated by real-time PCR and/or immunohistochemistry in fresh-frozen biopsies and paraffin-embedded tissues derived from a total of 137 patients including 69 primary EOC with different histologies, 28 serous papillary omental metastasis, 8 borderline tumors, 26 benign cystadenomas and 14 normal ovaries.	Paraffin	122-130	secretoglobin family 2A member 1	Homo sapiens	9-22
17492461-3	2007	Endogenous alkaline phosphatase activity could be completely blocked by heat inactivation in paraffin and MMA sections, allowing histochemical detection of hPLAP in the complete absence of background staining.	Paraffin	93-101	alkaline phosphatase, placental	Homo sapiens	156-161
17492461-7	2007	In conclusion, hPLAP provides superb detection quality in paraffin and plastic sections, and constitutes an excellent genetic marker for cell tracking in hard and soft tissues.	Paraffin	58-66	alkaline phosphatase, placental	Homo sapiens	15-20
17425388-5	2007	RESULTS: Ten cases were positive for thyroid transcription factor 1, which was confirmed on subsequent paraffin sections.	Paraffin	103-111	NK2 homeobox 1	Homo sapiens	37-67
17522398-2	2007	METHODS: We estimated cyclooxygenase-2 (COX-2) expression by immunohistochemical assay of sections from paraffin-embedded colorectal-cancer specimens from two large cohorts of participants who provided data on aspirin use from a questionnaire every 2 years.	Paraffin	104-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	22-38
17522398-2	2007	METHODS: We estimated cyclooxygenase-2 (COX-2) expression by immunohistochemical assay of sections from paraffin-embedded colorectal-cancer specimens from two large cohorts of participants who provided data on aspirin use from a questionnaire every 2 years.	Paraffin	104-112	prostaglandin-endoperoxide synthase 2	Homo sapiens	40-45
17493233-1	2007	AIMS: To report on the mutation-specific restriction enzyme digest (MSRED) method using paraffin-embedded tissue as a means of detecting GNAS1 mutations in fibrous dysplasia (FD), and to determine if any of the reported GNAS1 mutations in endocrine neoplasms, not previously documented in FD, can be found in FD.	Paraffin	88-96	GNAS complex locus	Homo sapiens	137-142
17712964-7	2007	The expression of TNF-alpha protein in paraffin-embedded lung sections with Streptavidin/ peroxidase(SP) immunohistochemistry on tissue microarray were measured by image-pro Plus.	Paraffin	39-47	tumor necrosis factor	Rattus norvegicus	18-27
17391929-2	2007	Streptavidin peroxidase immunohistochemical staining was used to detect the expression level of iNOS and CD34 in paraffin-embedded samples from 25 patients.	Paraffin	113-121	nitric oxide synthase 2	Homo sapiens	96-100
17391929-2	2007	Streptavidin peroxidase immunohistochemical staining was used to detect the expression level of iNOS and CD34 in paraffin-embedded samples from 25 patients.	Paraffin	113-121	CD34 molecule	Homo sapiens	105-109
17505259-4	2007	The expression of COX-2 was determined immunohistochemically in formalin-fixed, paraffin-embedded specimens of 33 early Clark I/II melanomas and 58 naevi.	Paraffin	80-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
17974277-3	2007	PRDM1 protein was detected in paraffin-embedded tissue by immunohistochemistry.	Paraffin	30-38	PR/SET domain 1	Homo sapiens	0-5
17974277-6	2007	RESULTS: (1) PRDM1 protein was found in paraffin-embedded tissues in 90.0% (18/20) of squamous cell carcinoma, 13.3% (2/15) of adenocarcinoma, and 0 (0/10) small cell lung cancer.	Paraffin	40-48	PR/SET domain 1	Homo sapiens	13-18
17380529-3	2007	METHODS: P53 expression was determined by immunohistochemistry in paraffin-embedded tissue specimens from 107 consecutive patients (107 primary squamous cell carcinomas of the supraglottic larynx and 46 matched lymph node metastases).	Paraffin	66-74	tumor protein p53	Homo sapiens	9-12
17438182-7	2007	Analysis of DNA from paraffin-embedded tissues showed loss of heterozygosity at CDKN2A loci in all 3 melanomas studied but not in Hodgkin lymphoma.	Paraffin	21-29	cyclin dependent kinase inhibitor 2A	Homo sapiens	80-86
17549665-2	2007	METHODS: BAG-1 expression was evaluated by immunohistochemistry in paraffin-embedded tissues of leukoplakia (n=25) and carcinoma of the tongue (n=61).	Paraffin	67-75	BAG cochaperone 1	Homo sapiens	9-14
17394498-7	2007	CONCLUSIONS: We have analysed PTPgamma expression in archival paraffin-embedded tissues for the first time, demonstrating particularly high expression in endocrine cells and both down- and up-regulation in neoplasia, the latter possibly reflecting the undifferentiated state of the neoplastic cells, suggesting a complex role for this phosphatase.	Paraffin	62-70	protein tyrosine phosphatase receptor type G	Homo sapiens	30-38
17471153-0	2007	Molecular detection of SS18-SSX fusion gene transcripts by cRNA in situ hybridization in synovial sarcoma using formalin-fixed, paraffin-embedded tumor tissue specimens.	Paraffin	128-136	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	23-27
17471153-9	2007	Our results suggest that BT-based ISH can be used as a molecular technique for the detection of SS18-SSX using formalin-fixed, paraffin-embedded tissues.	Paraffin	127-135	SS18 subunit of BAF chromatin remodeling complex	Homo sapiens	96-100
16933138-3	2007	CASE REPORT: We investigated the expression of E-cadherin and N-cadherin in paraffin-embedded sequential surgical specimens and autopsy specimens from a 4-year-old girl with recurrent ependymoma, subsequent to cerebrospinal fluid (CSF) dissemination.	Paraffin	76-84	cadherin 1	Homo sapiens	47-57
17362749-4	2007	Immunohistochemical techniques using monoclonal anti-CD20 antibody was used on paraffin sections from 38 renal allograft biopsy specimens.	Paraffin	79-87	keratin 20	Homo sapiens	53-57
17217995-2	2007	To further investigate the hypothesis that AR gene amplification is associated with increased cell proliferation, we analyzed 123 paraffin-embedded prostate cancer specimens from men who experienced tumor relapse during androgen withdrawal therapy.	Paraffin	130-138	androgen receptor	Homo sapiens	43-45
17295648-7	2007	Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L2 fusion transcripts.	Paraffin	85-93	FUS RNA binding protein	Homo sapiens	119-122
17535680-2	2007	METHODS: Immunohistochemistry EnVision method was used to detect E-cadherin and beta-catenin expression in 90 paraffin-embedded tissue samples of neuroblastomas.	Paraffin	110-118	cadherin 1	Homo sapiens	65-75
17535680-3	2007	The methylation status of CpG islands of E-cadherin promoter was investigated by MSP in 7 fresh tissue and 24 paraffin-embedded tissue samples.	Paraffin	110-118	cadherin 1	Homo sapiens	41-51
17251340-0	2007	Improved detection of KIT exon 11 duplications in formalin-fixed, paraffin-embedded gastrointestinal stromal tumors.	Paraffin	66-74	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	22-25
16977458-3	2007	METHODS: Fluorescent in situ hybridization was used to analyse the C-MYC and CDKN2A genes on isolated nuclei from 49 paraffin-embedded primary NMs.	Paraffin	117-125	cyclin dependent kinase inhibitor 2A	Homo sapiens	77-83
17251340-8	2007	Use of the PCR assay amplifying the specific region affected by duplications and yielding 129 bp in wild-type KIT can substantially improve the detection of these mutations in formalin-fixed, paraffin-embedded GISTs.	Paraffin	192-200	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	110-113
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Paraffin	104-112	caspase 1	Homo sapiens	206-215
16854613-2	2007	EGFR expression was examined immunohistochemically on a tissue microarray (TMA) of paraffin embedded tissue specimens from 109 patients who underwent surgical treatment for squamous cell carcinoma of the oral cavity and oropharynx in the period between 1980 and 1997.	Paraffin	83-91	epidermal growth factor receptor	Homo sapiens	0-4
17255298-7	2007	Our group has recently reported that B7-H1 is aberrantly expressed in both primary and metastatic renal cell carcinoma (RCC) as revealed via immunohistochemical staining of both fresh-frozen and paraffin-embedded nephrectomy specimens.	Paraffin	195-203	CD274 antigen	Mus musculus	37-42
17404013-5	2007	By means of immunohistochemistry we estimated the level of overexpression of bcl-2 proteins in a series of the 26 formalin fixed, paraffin-embedded samples of oral squamous cell carcinoma (OSCC).	Paraffin	130-138	BCL2 apoptosis regulator	Homo sapiens	77-82
17223848-1	2007	The study aimed to demonstrate the expression of nitric oxide converting enzyme, nitric oxide synthase (e-NOS), and endothelin-1 (Et-1) in formalin-fixed paraffin-embedded placental tissue, and to demonstrate a difference in staining intensity between heavy smokers and non-smokers.	Paraffin	154-162	endothelin 1	Homo sapiens	130-134
18165170-13	2007	For immunoohistochemical expression of ERalpha paraffin-embedded specimens fixed in 4% buffered formalin were used.	Paraffin	47-55	estrogen receptor 1	Homo sapiens	39-46
17452774-2	2007	METHODS: Expression of HIF-1alpha and proteins in the HIF-1alpha pathway (Glut-1, CAIX, VEGF) in paraffin-embedded specimens of normal (n=17), premalignant (n=17) and endometrioid endometrial carcinoma (n=39) was explored by immunohistochemistry, in relation to microvessel density (MVD).	Paraffin	97-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	23-33
17452774-2	2007	METHODS: Expression of HIF-1alpha and proteins in the HIF-1alpha pathway (Glut-1, CAIX, VEGF) in paraffin-embedded specimens of normal (n=17), premalignant (n=17) and endometrioid endometrial carcinoma (n=39) was explored by immunohistochemistry, in relation to microvessel density (MVD).	Paraffin	97-105	hypoxia inducible factor 1 subunit alpha	Homo sapiens	54-64
17406061-7	2007	Using indirect immunoperoxidase staining of paraffin-embedded sections, active caspase-3 was found in infarcted neurons that co-localized with TUNEL-positive cells.	Paraffin	44-52	caspase 3	Homo sapiens	79-88
17597023-13	2007	The expression of caspase-3 positive cells was determined immunohistochemically in paraffin-embedded specimens.	Paraffin	83-91	caspase 3	Homo sapiens	18-27
17419234-3	2007	METHODOLOGY: Expression of the VEGF-C and VEGF-D in human submucosal colorectal cancers was investigated in paraffin-embedded stepwise sections by means of immunohistochemistry, and the correlation between immunohistochemical expression pattern and clinicopathological features was also evaluated.	Paraffin	108-116	vascular endothelial growth factor C	Homo sapiens	31-37
17177989-5	2006	METHODS: MDR-1 has been studied by standard LSAB-HRP immunohistochemical technique, in paraffin embedded RCC samples.	Paraffin	87-95	ATP binding cassette subfamily B member 1	Homo sapiens	9-14
17395400-3	2007	The present study investigates the immunohistochemical expression of seven essential cell cycle proteins (p21, p27, p14, p16, p53, mdm2, and cyclin E) in paraffin-embedded sections from 42 bone marrow biopsies obtained from an equal number of patients with newly diagnosed acute myeloid leukemia (AML).	Paraffin	154-162	cyclin dependent kinase inhibitor 1A	Homo sapiens	106-109
18500171-1	2007	In this paper, we investigated Cdx2 and claudin-2 expression in pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy to determine the correlation between the expressions of these 2 genes during gastric carcinogenesis by immunochemical ABC technique.	Paraffin	77-85	claudin 2	Homo sapiens	40-49
17201750-1	2006	CD34 is considered a pan-endothelial cell marker for paraffin-embedded sections.	Paraffin	53-61	CD34 molecule	Homo sapiens	0-4
16938384-7	2006	Similar patterns of zHSF1a and zHSF2 mRNA expression in the brain regions of developing zebrafish were detected by whole mount in situ hybridization and paraffin sectioning, suggesting that most of the two HSF gene activities were controlled by a common mechanism during the embryonic development of zebrafish.	Paraffin	153-161	heat shock transcription factor 2	Danio rerio	31-36
16556662-11	2006	CONCLUSIONS: Immunohistochemical staining for adipophilin and perilipin is a useful ancillary technique for the demonstration of lipid in SGC that may be applied to paraffin-wax sections.	Paraffin	165-177	perilipin 2	Homo sapiens	46-57
17109742-4	2006	RESULTS: In the formalin-fixed and paraffin embedded normal canine liver vimentin showed staining of hepatic fibroblasts, probably including MF in portal areas and around hepatic veins; however, HSC were in general negative.	Paraffin	35-43	vimentin	Canis lupus familiaris	73-81
17088985-3	2006	P-glycoprotein was assessed by immunohistochemistry on paraffin-embedded tissue samples collected at time of diagnosis from 94 osteosarcoma patients, treated with the Italian Sarcoma Group/Scandinavian Sarcoma Group 1 (ISG/SSG 1) protocol.	Paraffin	55-63	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
17143353-4	2006	At the end of dietary treatment, a single dose of CCl4 (2.5 ml/kg intraperitoneally) in paraffin (1:1 v/v) was given to 6 rats in each group after overnight fasting.	Paraffin	88-96	C-C motif chemokine ligand 4	Rattus norvegicus	50-54
17063086-6	2006	Immunohistochemical analysis of routinely processed paraffin-embedded bone marrow sections showed that CBFbeta-SMMHC staining is predominantly nuclear in all cases of AML-M4Eo and is not nuclear in other AML types.	Paraffin	52-60	myosin heavy chain 11	Homo sapiens	111-116
16678891-3	2006	METHODS: We assessed by immunohistochemistry the expression of the Ep-CAM antigen on tissue microarrays containing paraffin-embedded tissue samples of 199 patients with documented EOC.	Paraffin	115-123	epithelial cell adhesion molecule	Homo sapiens	67-73
17374210-2	2006	METHODS: Immunohistochemical study for caveolin-1 and CD34 was performed on paraffin sections of 154 cases of primary lung cancer and adjacent non-neoplastic lung parenchymal tissue, as well as 36 cases with nodal metastasis.	Paraffin	76-84	caveolin 1	Homo sapiens	39-49
16938666-6	2006	Pax-5, BOB.1, and CD79a antigens are the most reliable B-lineage markers for paraffin immunophenotyping B-ALL/B-LBL.	Paraffin	77-85	CD79a molecule	Homo sapiens	18-23
16984257-5	2006	Real-time quantitative RT-PCR assay performed on mRNA extracted from formalin-fixed paraffin-embedded CCA and normal skin (NS) samples further demonstrated the overexpression of the KGF/FGF-7 gene in all CCA samples compared with NS.	Paraffin	84-92	fibroblast growth factor 7	Homo sapiens	182-185
16984257-5	2006	Real-time quantitative RT-PCR assay performed on mRNA extracted from formalin-fixed paraffin-embedded CCA and normal skin (NS) samples further demonstrated the overexpression of the KGF/FGF-7 gene in all CCA samples compared with NS.	Paraffin	84-92	fibroblast growth factor 7	Homo sapiens	186-191
16949920-5	2006	In a combined analysis of immunohistochemistry and fluorescence in situ hybridization on 552 formalin-fixed and paraffin-embedded gastric cancer tissues, 38 cases were found to have HER2 amplification.	Paraffin	112-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	182-186
16595146-5	2006	METHODS: TSP 1 expression was investigated by immunohistochemistry from paraffin-embedded tissue in 26 patients with leiomyoma, in 24 patients with STUMP and in 21 patients with LMS.	Paraffin	72-80	thrombospondin 1	Homo sapiens	9-14
17183836-1	2006	The present study provides an analysis of immunohistochemical expression and localization of epidermal growth factor receptor (EGFR) in formalin fixed paraffin embedded specimens of prostate.	Paraffin	151-159	epidermal growth factor receptor	Homo sapiens	93-125
17183836-1	2006	The present study provides an analysis of immunohistochemical expression and localization of epidermal growth factor receptor (EGFR) in formalin fixed paraffin embedded specimens of prostate.	Paraffin	151-159	epidermal growth factor receptor	Homo sapiens	127-131
16916505-0	2006	HER-2 DNA quantification of paraffin-embedded breast carcinomas with LightCycler real-time PCR in comparison to immunohistochemistry and chromogenic in situ hybridization.	Paraffin	28-36	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
16621014-0	2006	Microwave-assisted antigen retrieval and incubation with cox-2 antibody of archival paraffin-embedded human oligodendroglioma and astrocytomas.	Paraffin	84-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	57-62
16931951-0	2006	Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens.	Paraffin	109-117	FUS RNA binding protein	Homo sapiens	23-26
16931951-4	2006	In the present study, we conducted a reverse transcription-polymerase chain reaction assay to detect the FUS-CREB3L2 fusion transcripts using formalin-fixed, paraffin-embedded tumor tissue specimens from 16 LGFMSs including 3 cases with giant collagen rosettes.	Paraffin	158-166	FUS RNA binding protein	Homo sapiens	105-108
16517973-0	2006	Characterization of anti-TIMP-1 monoclonal antibodies for immunohistochemical localization in formalin-fixed, paraffin-embedded tissue.	Paraffin	110-118	TIMP metallopeptidase inhibitor 1	Homo sapiens	25-31
16517973-1	2006	The aim of this study was to evaluate seven anti-TIMP-1 (tissue inhibitor of metalloproteinase-1) monoclonal antibodies by immunohistochemical (IHC) staining of formalin-fixed, paraffin-embedded (FFPE) tissue.	Paraffin	177-185	TIMP metallopeptidase inhibitor 1	Homo sapiens	49-55
16964464-3	2006	Two protocols are proposed allowing the thermal demasking procedure to be avoided during detection of neuron marker NeuN on paraffin sections examined by light and confocal microscopy.	Paraffin	124-132	RNA binding fox-1 homolog 3	Homo sapiens	116-120
16948517-6	2006	A CD10 monoclonal antibody was applied to formalin-fixed, paraffin-embedded tissue.	Paraffin	58-66	membrane metalloendopeptidase	Homo sapiens	2-6
16916505-1	2006	OBJECTIVES: To compare the detection of HER-2 status by real-time PCR, on paraffin-embedded breast carcinomas, in respect to immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH).	Paraffin	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-45
16841374-5	2006	The approach has been validated by comparison of results with standard analyses for HER-2 amplification status in formalin-fixed, paraffin-embedded breast cancers and is applicable to the analysis of other clinically relevant genomic aberrations as well as of use in research investigations.	Paraffin	130-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	84-89
16839708-4	2006	EGFR expression in pretreatment paraffin-embedded tumor biopsy specimens was assessed by immunohistochemistry.	Paraffin	32-40	epidermal growth factor receptor	Homo sapiens	0-4
16673118-4	2006	The expression of CD10 was immunohistochemically examined in 47 paraffin embedded NPC biopsies from Tunisian patients compared with 16 reactional nasopharyngeal mucosas.	Paraffin	64-72	membrane metalloendopeptidase	Homo sapiens	18-22
17235726-4	2006	c-erbB-2 overexpression was evaluated using immunohistochemistry performed on archival paraffin-embedded specimens.	Paraffin	87-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
16898965-2	2006	Paraffin-embedded bone marrow samples (PE-BM) are, in most cases, the only tissue accessible to perform retrospective analyses of novel targets such as VEGF and/or its receptors.	Paraffin	0-8	vascular endothelial growth factor A	Homo sapiens	152-156
16739114-3	2006	This paper documents Jaw1/LRMP expression at the protein level in human tissues by immunohistochemical and western blotting analysis using an antibody reactive with paraffin-embedded tissues.	Paraffin	165-173	inositol 1,4,5-triphosphate receptor associated 2	Homo sapiens	21-25
16739114-3	2006	This paper documents Jaw1/LRMP expression at the protein level in human tissues by immunohistochemical and western blotting analysis using an antibody reactive with paraffin-embedded tissues.	Paraffin	165-173	inositol 1,4,5-triphosphate receptor associated 2	Homo sapiens	26-30
16863546-6	2006	Following microdissection and RNA isolation, quantitative real-time PCR was used to measure Cox-2 gene expression in paraffin-embedded (N = 16) and fresh frozen (N = 12) tissue.	Paraffin	117-125	prostaglandin-endoperoxide synthase 2	Homo sapiens	92-97
16863546-8	2006	RESULTS: Median Cox-2 expression in the squamous epithelium from paraffin embedded biopsies in patients with reflux disease was significantly increased compared to controls (p = 0.04).	Paraffin	65-73	prostaglandin-endoperoxide synthase 2	Homo sapiens	16-21
16835330-6	2006	p53 protein accumulation was assessed immunohistochemically using sections of paraffin-embedded benign breast tissue from 104 cases and 385 controls; for 82 of these cases and 327 of the controls, DNA was successfully extracted from the breast tissue for p53 gene analysis using PCR-single-strand conformation polymorphism/direct sequencing.	Paraffin	78-86	tumor protein p53	Homo sapiens	0-3
16785783-5	2006	Immunohistochemical evaluation of TRAIL expression was performed on formalin-fixed paraffin-embedded sections from 29 GE junction/esophageal biopsies, 20 gastric biopsies, 6 esophagectomies, 2 small bowel resection specimens, and 5 colon biopsies.	Paraffin	83-91	TNF superfamily member 10	Homo sapiens	34-39
16825506-3	2006	We therefore developed a new assay for detecting EGFR mutation using only a paraffin section of a small biopsy specimen.	Paraffin	76-84	epidermal growth factor receptor	Homo sapiens	49-53
16780589-4	2006	The expression of SCF receptor Kit was assessed using immunostaining of paraffin-embedded bronchial sections.	Paraffin	72-80	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	31-34
16723714-3	2006	Here, we developed a novel allele-specific real-time PCR assay to detect the Cav-1 P132L mutation in mammary tumor cells isolated by laser capture microdissection from formalin-fixed paraffin-embedded breast cancer samples.	Paraffin	183-191	caveolin 1	Homo sapiens	77-82
16785796-0	2006	Development of new rabbit monoclonal antibody to progesterone receptor (Clone SP2): no heat pretreatment but effective for paraffin section immunohistochemistry.	Paraffin	123-131	Sp2 transcription factor	Homo sapiens	78-81
16785796-3	2006	The authors developed the first rabbit anti-PgR mAb (clone SP2) used in IHC on formalin-fixed, paraffin-embedded tissue sections from breast carcinomas.	Paraffin	95-103	Sp2 transcription factor	Homo sapiens	59-62
16685386-9	2006	The current study suggests that DNA extraction with the DEXPAT kit followed by nested PCR is a simple and reliable technique for analyzing the EGFR gene status with paraffin-embedded samples.	Paraffin	165-173	epidermal growth factor receptor	Homo sapiens	143-147
16682728-4	2006	Amplification of HER-2/neu was determined retrospectively in paraffin-embedded tumor tissue sections by chromogenic in situ hybridization.	Paraffin	61-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-26
16574270-5	2006	c-kit, analyzed as immunohistochemical expression in paraffin-embedded tumour tissues, was observed in 60% of patients.	Paraffin	53-61	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
16718800-2	2006	METHODS: The expression of TFF1 and TFF2 was immunohistochemically analyzed in paraffin-embedded samples from 140 patients including 35 cases of chronic superficial gastritis (CSG), 35 cases of gastric ulcer (GU), 35 cases of chronic atrophic gastritis (CAG) and 35 cases of gastric cancer (GC).	Paraffin	79-87	trefoil factor 1	Homo sapiens	27-31
16718800-2	2006	METHODS: The expression of TFF1 and TFF2 was immunohistochemically analyzed in paraffin-embedded samples from 140 patients including 35 cases of chronic superficial gastritis (CSG), 35 cases of gastric ulcer (GU), 35 cases of chronic atrophic gastritis (CAG) and 35 cases of gastric cancer (GC).	Paraffin	79-87	trefoil factor 2	Homo sapiens	36-40
16585013-2	2006	DESIGN AND METHODS: Here we document the expression of PRDM1 in normal and neoplastic lymphoid cells, through the use of a monoclonal antibody that recognizes the molecule in paraffin-embedded tissue sections.	Paraffin	175-183	PR/SET domain 1	Homo sapiens	55-60
16634810-3	2006	In this study, we investigated for the first time, the glomerular expression of phosphorylated STAT3 in paraffin sections from animals with experimental mesangial proliferative glomeronephritis.	Paraffin	104-112	signal transducer and activator of transcription 3	Homo sapiens	95-100
16795991-1	2006	BACKGROUND/AIMS: To evaluate epidermal growth factor receptor (EGFR) gene status in pancreatic ductal adenocarcinoma correlating the results to protein expression and clinicopathological features METHODOLOGY: Using tissue microarray technology (TMArrayer 100), fifty (n = 50) paraffin-embedded tissue samples of histologically-confirmed primary tumors were cored twice at a diameter of 1 mm and re-embedded into the final recipient block.	Paraffin	276-284	epidermal growth factor receptor	Homo sapiens	63-67
16700663-5	2006	An immunohistochemical method was used to investigate the expression of COX-2 and p53 proteins on formalin-fixed, paraffin-embedded tissue specimens of squamous cell carcinomas (SCC), basal cell carcinomas (BCC), Bowen"s disease (BD), actinic keratosis (AK) and porokeratosis.	Paraffin	114-122	prostaglandin-endoperoxide synthase 2	Homo sapiens	72-77
16700663-5	2006	An immunohistochemical method was used to investigate the expression of COX-2 and p53 proteins on formalin-fixed, paraffin-embedded tissue specimens of squamous cell carcinomas (SCC), basal cell carcinomas (BCC), Bowen"s disease (BD), actinic keratosis (AK) and porokeratosis.	Paraffin	114-122	tumor protein p53	Homo sapiens	82-85
16784656-6	2006	(2) On apoptosis-related gene proteins, the expression of Bcl-2 was significantly decreased in paraffin sections of NCTD group when compared with control group (P &lt; 0.05); The expression of Bcl-2 mRNA, Survivin mRNA was significantly decreased, with significantly increased expression of Bax mRNA in NCTD group.	Paraffin	95-103	B cell leukemia/lymphoma 2	Mus musculus	58-63
16784656-6	2006	(2) On apoptosis-related gene proteins, the expression of Bcl-2 was significantly decreased in paraffin sections of NCTD group when compared with control group (P &lt; 0.05); The expression of Bcl-2 mRNA, Survivin mRNA was significantly decreased, with significantly increased expression of Bax mRNA in NCTD group.	Paraffin	95-103	B cell leukemia/lymphoma 2	Mus musculus	193-198
21144307-4	2006	METHODS: The expression of VEGF-C and podoplanin were detected in 66 paraffin sections of NSCLC and 8 inflammatory pseudotumor tissues by immunohistochemistry (SP).	Paraffin	69-77	vascular endothelial growth factor C	Homo sapiens	27-33
16469859-9	2006	Multiplex aQRT-PCR reliably identified the HER-2 gene in microdissected breast cancer samples; in formalin-fixed, paraffin-embedded specimens; and in plasma circulating DNA from cancer patients.	Paraffin	114-122	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-48
16133023-2	2006	METHODS: The expression patterns of hTR and hTRT were detected by in situ hybridization (ISH) in paraffin-embedded samples of 55 eyelid sebaceous gland carcinoma, 12 chalazia, and four sebaceous adenoma.	Paraffin	97-105	telomerase RNA component	Homo sapiens	36-39
16269171-4	2006	METHODS: The expression of E7, TGF-beta1, TbetaR-II and Smad4 was detected by immunohistochemistry in paraffin-embedded cervical samples, and by RT-PCR and Western blotting in cervical cancer cell lines.	Paraffin	102-110	transforming growth factor beta 1	Homo sapiens	31-40
16827107-5	2006	MATERIALS AND METHODS: Immunohistochemistry was employed to analyze the protein expression of p53, deltaNp73 and deltaNp63 in paraffin-embedded tumor samples from 132 well-characterized lung cancer patients.	Paraffin	126-134	tumor protein p53	Homo sapiens	94-97
16638859-3	2006	EXPERIMENTAL DESIGN: We immunohistochemically examined GnT-V expression in paraffin-embedded bladder cancer specimen using anti-GnT-V monoclonal antibody.	Paraffin	75-83	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	55-60
16616093-2	2006	DESIGN: Immunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues.	Paraffin	89-97	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-41
16426842-3	2006	This study investigated the clinical significance of RARRES1 protein and its association with RARRES3 protein expression in 161 (26 adenoma, 13 distal normal mucosa and 122 primary colorectal adenocarcinoma) paraffin-embedded colorectal tissues by immunohistochemistry.	Paraffin	208-216	retinoic acid receptor responder 1	Homo sapiens	53-60
16546643-4	2006	PATIENTS AND METHODS: Expression of NGF and TrkA was explored using immunohistochemistry in paraffin-embedded tissues of 32 cases of salivary ACC.	Paraffin	92-100	nerve growth factor	Homo sapiens	36-39
16875632-2	2006	METHODS: Immunohistochemical staining for c-erbB2 was performed on paraffin-embedded specimens of primary breast cancer from 284 patients, and the relation to its prognosis was statistically analyzed.	Paraffin	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-49
16507908-6	2006	Paraffin-embedded tissue blotting analysis showed PrP(Sc) in skeletal muscle in localized anatomical structures that had the morphological and immunohistochemical characteristics of nerve fibers.	Paraffin	0-8	prion protein	Homo sapiens	50-53
16847810-5	2006	p53 and HER2/neu protein expression were evaluated by immunohistochemistry (IHC) using antibodies against p53 (clone PAb 1801, Novocastra) and against HER2/neu (Dako) in paraffin-embedded specimens of tumors.	Paraffin	170-178	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-159
16463269-3	2006	STAT3 activation was assessed by immunohistochemistry using a monoclonal antibody specific for tyrosine(705)-phosphorylated STAT3 (pSTAT3(tyr705)) and a tissue microarray containing 49 paraffin-embedded ESFT tumours with known EWS translocations.	Paraffin	185-193	signal transducer and activator of transcription 3	Homo sapiens	0-5
16586562-4	2006	Tumor DNA extracted from paraffin-embedded specimens revealed somatic mutation with a deletion mutation at different codons in exon 11 of c-kit gene after direct sequencing analysis.	Paraffin	25-33	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	138-143
16495697-5	2006	METHODS: We evaluated the immunohistochemical expression of CA IX and VEGF on paraffin-embedded material of 154 resection specimens: 39 esophageal, 73 cardiac, and 42 distal gastric adenocarcinomas (UICC classification).	Paraffin	78-86	vascular endothelial growth factor A	Homo sapiens	70-74
16426842-3	2006	This study investigated the clinical significance of RARRES1 protein and its association with RARRES3 protein expression in 161 (26 adenoma, 13 distal normal mucosa and 122 primary colorectal adenocarcinoma) paraffin-embedded colorectal tissues by immunohistochemistry.	Paraffin	208-216	phospholipase A and acyltransferase 4	Homo sapiens	94-101
16487366-3	2006	METHODS AND RESULTS: Anti-NeuN immunohistochemistry was performed on paraffin-embedded biopsy specimens of 106 diffuse astrocytomas, 100 pilocytic astrocytomas, 107 ependymomas, 59 1p-aberrant oligodendroglial neoplasms, 115 glioblastomas, 115 medulloblastomas, 14 gangliogliomas/gangliocytomas and 10 central neurocytomas.	Paraffin	69-77	RNA binding fox-1 homolog 3	Homo sapiens	26-30
16152581-4	2006	EGFR mutation was assessed from DNA of 63 paraffin-embedded small needle biopsy/aspiration specimens from 62 patients with NSCLC treated with gefitinib.	Paraffin	42-50	epidermal growth factor receptor	Homo sapiens	0-4
16152581-11	2006	In conclusion, EGFR mutation analysis is feasible in needle biopsy/aspiration paraffin-fixed specimens.	Paraffin	78-86	epidermal growth factor receptor	Homo sapiens	15-19
16489060-6	2006	EXPERIMENTAL DESIGN: The expression of PHD2 was studied from paraffin-embedded normal tissue (n = 21) and head and neck squamous cell carcinoma (HNSCC; n = 44) by immunohistochemistry.	Paraffin	61-69	egl-9 family hypoxia inducible factor 1	Homo sapiens	39-43
16467085-9	2006	RESULTS: EGFR mutations were detected in 16 of 61 fresh frozen tumor specimens, 24 of 91 dissected formalin-fixed, paraffin-embedded tumor specimens, and 11 of 26 undissected formalin-fixed, paraffin-embedded tumor specimens.	Paraffin	115-123	epidermal growth factor receptor	Homo sapiens	9-13
16467085-9	2006	RESULTS: EGFR mutations were detected in 16 of 61 fresh frozen tumor specimens, 24 of 91 dissected formalin-fixed, paraffin-embedded tumor specimens, and 11 of 26 undissected formalin-fixed, paraffin-embedded tumor specimens.	Paraffin	191-199	epidermal growth factor receptor	Homo sapiens	9-13
16420307-4	2006	METHODS: CD10 protein immunohistochemistry was performed on paraffin-embedded biopsies of 13 TE and 23 BCC diagnosed by routine microscopy.	Paraffin	60-68	membrane metalloendopeptidase	Homo sapiens	9-13
16406879-6	2006	Paraffin embedded tumor specimens were immunohistochemically examined by the avidin-biotin peroxidase method using monoclonal antibody against GnT-V.	Paraffin	0-8	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	143-148
16825764-8	2006	In situ hybridization on paraffin sections of mouse tissues demonstrated that Hmbox1 is widely expressed in pancreas and the expression of this gene can also be detected in pallium, hippocampus and hypothalamus.	Paraffin	25-33	homeobox containing 1	Mus musculus	78-84
16204226-3	2006	The aim of our study was to work out a reliable, immunohistochemical detection of the stress-inducible Hsp70i protein and enabling discrimination between Hsp70i and Hsc70 proteins in paraffin-embedded human tissues.	Paraffin	183-191	heat shock protein family A (Hsp70) member 1A	Homo sapiens	103-109
16204226-7	2006	In liver tissue embedded in paraffin, regardless the fixative used, positive Hsp70i staining could be visible only if antigen retrieval was applied.	Paraffin	28-36	heat shock protein family A (Hsp70) member 1A	Homo sapiens	77-83
16432453-7	2006	The expression of COX-2 was determined immunohistochemically in formalin-fixed, paraffin-embedded specimens of 64 human melanocytic skin tumours (17 naevi, 36 primary cutaneous melanomas and 11 lymph node melanoma metastases, with six pairs of primary and metastatic lesions obtained from the same patients).	Paraffin	80-88	prostaglandin-endoperoxide synthase 2	Homo sapiens	18-23
16649377-4	2006	Proper quality paraffin blocks were chosen for immunohistochemical staining for P53 through the immunoperoxidase method.	Paraffin	15-23	tumor protein p53	Homo sapiens	80-83
17219721-2	2006	The localization of PCNA was demonstrated in paraffin sections of pig ovarian tissue using primary mouse monoclonal anti-PCNA antibody.	Paraffin	45-53	proliferating cell nuclear antigen	Sus scrofa	20-24
17455801-0	2006	Retrospective sequence analysis of the human PRNP gene from the formaldehyde-fixed paraffin-embedded tissues: report of two cases of Creutzfeldt-Jakob disease.	Paraffin	83-91	prion protein	Homo sapiens	45-49
16569359-1	2006	Our study is aimed at evaluating the presence of p53 and Ki67 expression by immunohistochemistry in a series of 11 paraffin-embedded penile carcinomas.	Paraffin	115-123	tumor protein p53	Homo sapiens	49-52
16761510-4	2006	Upon standard procedure of formalin fixation, embedding in paraffin and examination of slides stained with hematoxillin-eosin, a semiquantitaive method of evaluation of immunohistochemical expression of the HER-2 protein has been performed in all tissue samples of the tumor.	Paraffin	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	207-212
16297499-3	2006	Bcl-xL expression was assessed on paraffin sections by in situ hybridization (ISH) and immunohistochemistry (IMH).	Paraffin	34-42	BCL2 like 1	Homo sapiens	0-6
16930013-7	2006	In this chapter, we present methodology for detection of genetic inactivation of TSC1 and TSC2 in paraffin-embedded archival tissues.	Paraffin	98-106	TSC complex subunit 1	Homo sapiens	81-85
16491599-0	2006	Measurement of estrogen receptor status by immunocytochemistry in paraffin wax sections.	Paraffin	66-78	estrogen receptor 1	Homo sapiens	15-32
16491599-3	2006	In particular, ER status as determined on paraffin sections by immunocytochemical assay has been shown to be superior to the ligand-binding assay for predicting response to adjuvant endocrine therapy in breast cancer.	Paraffin	42-50	estrogen receptor 1	Homo sapiens	15-17
16491599-7	2006	The aim of this chapter is to describe the methodology currently used for optimal reproducible demonstration, scoring, and assessment of ER status in paraffin wax-embedded tissue sections in relation to the management of breast cancer in a routine or clinical-trial setting.	Paraffin	150-162	estrogen receptor 1	Homo sapiens	137-139
16675157-4	2006	We performed methylation-specific PCR of p16INK4a and p14ARF genes in colorectal cancer paraffin blocks with its paired normal samples, as well as immunohistochemical stainings for p16 and p53, and MI analysis.	Paraffin	88-96	cyclin dependent kinase inhibitor 2A	Homo sapiens	41-49
17671399-3	2006	METHODS: The VEGF genotypes were determined using paraffin-embedded tissue from 413 patients who underwent a surgical resection and peripheral blood lymphocytes from 413 healthy controls by PCR-RFLP assay.	Paraffin	50-58	vascular endothelial growth factor A	Homo sapiens	13-17
16675157-4	2006	We performed methylation-specific PCR of p16INK4a and p14ARF genes in colorectal cancer paraffin blocks with its paired normal samples, as well as immunohistochemical stainings for p16 and p53, and MI analysis.	Paraffin	88-96	cyclin dependent kinase inhibitor 2A	Homo sapiens	54-60
16675157-4	2006	We performed methylation-specific PCR of p16INK4a and p14ARF genes in colorectal cancer paraffin blocks with its paired normal samples, as well as immunohistochemical stainings for p16 and p53, and MI analysis.	Paraffin	88-96	cyclin dependent kinase inhibitor 2A	Homo sapiens	41-44
16401921-2	2006	METHODS: Cox-2 expression was examined immunohistochemically in paraffin blocks of 99 patients.	Paraffin	64-72	prostaglandin-endoperoxide synthase 2	Homo sapiens	9-14
17189989-0	2006	Protocol modifications influence the result of EGF receptor immunodetection by EGFR pharmDx in paraffin-embedded cancer tissues.	Paraffin	95-103	epidermal growth factor receptor	Homo sapiens	47-59
17189989-0	2006	Protocol modifications influence the result of EGF receptor immunodetection by EGFR pharmDx in paraffin-embedded cancer tissues.	Paraffin	95-103	epidermal growth factor receptor	Homo sapiens	79-83
17189989-4	2006	The golden standard for the determination of EGFR protein expression in paraffin-embedded cancer tissues is the EGFR pharmDxTM kit.	Paraffin	72-80	epidermal growth factor receptor	Homo sapiens	45-49
16311126-6	2005	A p53 protein immunohistochemical analysis was performed on paraffin-embedded tissues.	Paraffin	60-68	tumor protein p53	Homo sapiens	2-5
17867601-9	2006	By establishing methods for the detection of c-kit codon 816 mutations in paraffin-embedded tissues, the pathologist holds a central position in the diagnosis of systemic mastocytoses.	Paraffin	74-82	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	45-50
16324192-2	2005	METHODS AND RESULTS: Fluorescence in situ hybridization of the EGFR gene and CEP7 was carried out on paraffin-embedded material from 48 rectal carcinomas combined with immunohistochemical detection of EGFR with a polymer detection kit.	Paraffin	101-109	epidermal growth factor receptor	Homo sapiens	63-67
16311126-11	2005	Of 10 serous papillary carcinomas, 8 (80%) for which paraffin blocks were available overexpressed the p53 protein.	Paraffin	53-61	tumor protein p53	Homo sapiens	102-105
16457151-4	2005	METHODS: The protein expression of p185(HER2) and PTEN was examined by immunohistochemical stain in paraffin-embedded tissues of 94 (M:F, 52:42) gastric adenocarcinoma patients by using monoclonal antibody, and the results were related to clinicopathological variables and survival.	Paraffin	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-44
16386505-3	2005	MATERIALS AND METHODS: Nuclear PARP-1 immunohistochemical expression (clone: PARP01) was studied in 155 paraffin-embedded renal biopsies from suboptimal donors and 95 kidney allograft biopsies with histopathological diagnosis of ATN.	Paraffin	104-112	poly(ADP-ribose) polymerase 1	Homo sapiens	31-37
15876524-10	2005	For paraffin-embedded tissue vWF gave higher values for vascularity than CD31.	Paraffin	4-12	von Willebrand factor	Homo sapiens	29-32
15876524-12	2005	Comparison of the results for fresh frozen tissue and paraffin-processed tissue suggests that this is acceptable for vWF but not for CD31.	Paraffin	54-62	von Willebrand factor	Homo sapiens	117-120
16375215-4	2005	Immunostaining for p53 protein was performed on formalin-fixed, paraffin-embedded tissue sections, using the alkaline phosphatase antialkaline phosphatase (APAAP) method.	Paraffin	64-72	tumor protein p53	Homo sapiens	19-22
16105969-9	2005	CONCLUSION: This is the first localization of CCK1 receptors in human formalin-fixed, paraffin-embedded tissues at the cellular level.	Paraffin	86-94	C-C motif chemokine ligand 28	Homo sapiens	46-50
16536311-3	2005	FISH for HER2 gene expression status was performed using PathVysion DNA probe kit on the archival paraffin-embedded sections of breast cancer tissues from 28 Chinese female patients with immunohistochemical staining scores of (3 +), (2 +), (1 +) and 0.	Paraffin	98-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
16049311-0	2005	JAZF1/JJAZ1 gene fusion in endometrial stromal sarcomas: molecular analysis by reverse transcriptase-polymerase chain reaction optimized for paraffin-embedded tissue.	Paraffin	141-149	JAZF zinc finger 1	Homo sapiens	0-5
16243795-5	2005	EXPERIMENTAL DESIGN: An antibody specific against pSer70 Bcl-2 was generated for thorough immunohistochemical examination of paraffin-embedded tumor specimens, allowing detection of the endogenously expressed antigen among a range of Bcl-2-positive colorectal neoplasms, including 75 tubular adenomas, 114 adenocarcinomas, and 15 cases of cancer in adenomas.	Paraffin	125-133	BCL2 apoptosis regulator	Homo sapiens	57-62
16166434-5	2005	Standard immunohistochemical techniques were used to study the expression of TSP-1 in 5-microm tumor sections from paraffin-embedded tissue blocks.	Paraffin	115-123	thrombospondin 1	Homo sapiens	77-82
15920704-1	2005	simultaneous detection of HER2/neu gene amplification and protein overexpression in paraffin-embedded breast cancer.	Paraffin	84-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-34
16091133-5	2005	By performing immunofluorescence staining after antigen retrieval of paraffin-embedded cervical tissue samples, this study reports for the first time that connexin26 and connexin30, in addition to connexin43, are expressed in differentiating cells of normal human cervical epithelia.	Paraffin	69-77	gap junction protein beta 2	Homo sapiens	155-165
16398406-4	2005	METHODS: MMP-13 expression was analyzed in 51 paraffin-embedded tumor samples from patients with invasive CMM, ten samples from in situ melanomas, and in eight samples from benign lesions (three dermal melanocytic nevi, three compound melanocytic nevi and two atypical melanocytic nevi) using immunohistochemical techniques.	Paraffin	46-54	matrix metallopeptidase 13	Homo sapiens	9-15
16536278-18	2005	RT-PCR successfully amplified the EWS-WT1 chimeric mRNA in 1 case using paraffin-embedded tissue.	Paraffin	72-80	WT1 transcription factor	Homo sapiens	34-41
16536278-24	2005	EWS-WT1 fusion transcript can be detected in formalin-fixed, paraffin-embedded tissue by RT-PCR, which may thus serve as a useful diagnostic adjunct for DSRCT.	Paraffin	61-69	WT1 transcription factor	Homo sapiens	0-7
16115926-14	2005	CONCLUSION: The AQUA system provides a continuous measurement of EGFR on paraffin-embedded tissue and was able to reveal the association between EGFR expression and outcome expected from the biological role of EGFR.	Paraffin	73-81	epidermal growth factor receptor	Homo sapiens	65-69
16115926-14	2005	CONCLUSION: The AQUA system provides a continuous measurement of EGFR on paraffin-embedded tissue and was able to reveal the association between EGFR expression and outcome expected from the biological role of EGFR.	Paraffin	73-81	epidermal growth factor receptor	Homo sapiens	145-149
16115926-14	2005	CONCLUSION: The AQUA system provides a continuous measurement of EGFR on paraffin-embedded tissue and was able to reveal the association between EGFR expression and outcome expected from the biological role of EGFR.	Paraffin	73-81	epidermal growth factor receptor	Homo sapiens	145-149
15956035-3	2005	The mutation analysis of the EGFR kinase domain was performed for 30 patients using paraffin-embedded tumor tissue.	Paraffin	84-92	epidermal growth factor receptor	Homo sapiens	29-33
16080576-3	2005	The IHC method of streptavidin biotin peroxidase on paraffin tissue sections was used to detect bcl2 and p53 oncoproteins and PAR4 pro-apoptotic protein expression in surgical specimens.	Paraffin	52-60	BCL2 apoptosis regulator	Homo sapiens	96-100
16012707-5	2005	By performing immunohistochemistry on paraffin-embedded tissue sections, we found that ptyr-845 EGFR was significantly co-expressed with Her-2/neu and ptyr-1248 Her-2/neu (p=0.043 and p=0.040, respectively), while ptyr-1173 EGFR was only correlated to Her-2/neu expression (p=0.042).	Paraffin	38-46	epidermal growth factor receptor	Homo sapiens	96-100
15978332-2	2005	The association of several clinicopathological parameters with the immunohistochemical expression of COX-2 was analyzed in paraffin-embedded esophageal cancer specimens.	Paraffin	123-131	prostaglandin-endoperoxide synthase 2	Homo sapiens	101-106
16080576-3	2005	The IHC method of streptavidin biotin peroxidase on paraffin tissue sections was used to detect bcl2 and p53 oncoproteins and PAR4 pro-apoptotic protein expression in surgical specimens.	Paraffin	52-60	tumor protein p53	Homo sapiens	105-108
15942643-5	2005	EpCAM expression on CTC was determined by flow cytometry (FCM) and by immunohistochemistry (IHC) in paraffin-embedded tissue.	Paraffin	100-108	epithelial cell adhesion molecule	Homo sapiens	0-5
15949590-4	2005	We used immunohistochemistry to analyze the protein expression of Grp78 in paraffin-embedded tumor samples from 132 well-characterized lung cancer patients and compared the expression level of Grp78, clinical variables and survival outcome.	Paraffin	75-83	heat shock protein family A (Hsp70) member 5	Homo sapiens	66-71
15924153-8	2005	Moreover, immunohistochemistry on paraffin-embedded tissue revealed c-FLIP expression in 39% (14 of 36) of NKTL patients.	Paraffin	34-42	CASP8 and FADD like apoptosis regulator	Homo sapiens	68-74
15976348-3	2005	METHODS: Expression of the c-kit protein was detected immunohistochemically in a total of 37 archival paraffin wax embedded NTs using polyclonal rabbit antihuman c-kit antibody.	Paraffin	102-114	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	27-32
15913990-1	2005	Expression of HER2 was evaluated by immunohistochemical techniques in 84 osteosarcoma (OS) and 113 Ewing"s sarcoma (ES) paraffin-embedded tumour biopsies.	Paraffin	120-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-18
15968330-0	2005	[Detection of EWS-WT1 fusion transcripts in paraffin-embedded tissues for desmoplastic small round cell tumor].	Paraffin	44-52	WT1 transcription factor	Homo sapiens	14-21
15968330-5	2005	CONCLUSION: The analysis of the EWS-WT1 fusion transcript which was performed on formalin-fixed, paraffin-embedded tissues is a sensitive and specific method in the diagnosis and differential diagnosis of DSRCT.	Paraffin	97-105	WT1 transcription factor	Homo sapiens	32-39
15958615-2	2005	EXPERIMENTAL DESIGN: The expression of phospho-Ser473-Akt (p-Akt) was assessed by immunohistochemistry in paraffin-embedded samples from patients enrolled in a Southwest Oncology Group clinical trial of gastroesophageal junction tumors and by immunohistochemistry and Western blotting in human colon tumor xenografts at various times after removal from the animal.	Paraffin	106-114	AKT serine/threonine kinase 1	Homo sapiens	54-57
16021567-0	2005	Immunohistochemical analysis of a muscle ankyrin-repeat protein, Arpp, in paraffin-embedded tumors: evaluation of Arpp as a tumor marker for rhabdomyosarcoma.	Paraffin	74-82	ankyrin repeat domain 2	Homo sapiens	65-69
15922891-2	2005	METHODS: E-cadherin expression was assessed immunohistochemically in sections from paraffin embedded tissues in a group of 54 patients with follicular carcinoma and its variants who were followed for a median of 7.25 years.	Paraffin	83-91	cadherin 1	Homo sapiens	9-19
15772955-4	2005	COX-2 expression was determined by immunohistochemical staining of formalin-fixed, paraffin-embedded tumor tissue.	Paraffin	83-91	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-5
16021575-7	2005	Because we found a differential expression in PAR-1 protein, but not in PAR-2, we next investigated the expression of PAR-1 messenger RNA (mRNA) by ribonuclease protection assay in paraffin-embedded tissues using a paraffin block RNA isolation procedure.	Paraffin	181-189	coagulation factor II thrombin receptor	Homo sapiens	118-123
15897572-3	2005	EXPERIMENTAL DESIGN: EGFR mutations in exons 18 to 21 were analyzed by DNA sequencing of paraffin-embedded tumor tissues from gefitinib-treated NSCLC patients.	Paraffin	89-97	epidermal growth factor receptor	Homo sapiens	21-25
15785748-7	2005	Owing to its potential as a novel therapeutic marker, expression of the high-affinity epithelial receptor for Clostridium perfringens enterotoxin (CPE) claudin-4 was further validated through immunohistochemical analysis of formalin-fixed paraffin-embedded specimens from which the primary USPC cultures were obtained, as well as an independent set of archival USPC specimens.	Paraffin	239-247	claudin 4	Homo sapiens	152-161
16158936-5	2005	Immunohistochemical staining for p53 was performed on paraffin-embedded tissue sections using the avidin-biotin-peroxidase method.	Paraffin	54-62	tumor protein p53	Homo sapiens	33-36
16158946-2	2005	MATERIALS AND METHODS: The expression of COX-2 was evaluated in 68 paraffin-embedded sporadic colorectal adenomas by immunohistochemistry.	Paraffin	67-75	prostaglandin-endoperoxide synthase 2	Homo sapiens	41-46
15786420-6	2005	The HER-2 gene was examined by fluorescence in situ hybridization either in paraffin-embedded tissue samples (48 primary tumors and 9 metastatic tumors) or in fine-needle aspirates (12 primary tumors and 51 metastatic tumors).	Paraffin	76-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	4-9
15863133-3	2005	METHODS: A total of 114 ovarian serous tumors, including 9 adenomas, 34 borderline, and 71 carcinomas, were analyzed immunohistochemically using a CD24 monoclonal antibody on paraffin blocks.	Paraffin	175-183	CD24 molecule	Homo sapiens	147-151
15868931-3	2005	HER2 gene status was evaluated on paraffin sections with the CISH technique using a digoxigenin-labeled DNA probe.	Paraffin	34-42	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
15732132-0	2005	Simultaneous detection of HER2/neu gene amplification and protein overexpression in paraffin-embedded breast cancer.	Paraffin	84-92	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-34
15746676-3	2005	STUDY DESIGN: Immunohistochemical evaluation was used to examine HER2/neu expression in paraffin blocks from 27 women with stage IA to IV uterine serous papillary endometrial cancer.	Paraffin	88-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-69
15746676-3	2005	STUDY DESIGN: Immunohistochemical evaluation was used to examine HER2/neu expression in paraffin blocks from 27 women with stage IA to IV uterine serous papillary endometrial cancer.	Paraffin	88-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	70-73
16105454-4	2005	The expression of iNOS protein in paraffin-embedded lung sections with Streptavidin/peroxidase (SP) immunohistochemistry on tissue microarray was measured by Image-Pro Plus.	Paraffin	34-42	nitric oxide synthase 2	Rattus norvegicus	18-22
15722800-0	2005	Development of new rabbit monoclonal antibody to estrogen receptor: immunohistochemical assessment on formalin-fixed, paraffin-embedded tissue sections.	Paraffin	118-126	estrogen receptor 1	Homo sapiens	49-66
15735172-4	2005	METHODS: Runx2/Cbfa1 and NFkappaB (p65) immunoreactivity was assessed on 11 paraffin wax embedded archival specimens of human primary osteosarcoma by standard immunohistochemical methods and scored on a scale of 0-3.	Paraffin	76-88	RUNX family transcription factor 2	Homo sapiens	9-14
15668953-0	2005	Determination of threshold values for determining the size of the fraction of steroid hormone receptor-positive tumor cells in paraffin-embedded breast carcinomas.	Paraffin	127-135	nuclear receptor subfamily 4 group A member 1	Homo sapiens	86-102
15668953-1	2005	BACKGROUND: For 4 years we used a multiparameter DNA flow cytometric (MP-FCM) technique to assess steroid hormone receptor expression in the diagnostic workup of routinely processed formalin-fixed, paraffin-embedded breast carcinomas as an alternative to immunohistochemistry (IHC) for the quantification of hormone receptor-positive cells.	Paraffin	198-206	nuclear receptor subfamily 4 group A member 1	Homo sapiens	106-122
15816493-3	2005	Immunohistochemical staining of the paraffin sections was performed using a polyclonal antibody to VEGF-C.	Paraffin	36-44	vascular endothelial growth factor C	Homo sapiens	99-105
15845181-2	2005	This study analyzed HIF-1a messenger RNA expression levels using real-time quantitative polymerase chain reaction (PCR) in paraffin-embedded surgical specimens from 54 stage IIB-III patients with non-small-cell lung cancer (NSCLC) treated with induction platinum/gemcitabine followed by surgery between September 1998 and December 2002.	Paraffin	123-131	hypoxia inducible factor 1 subunit alpha	Homo sapiens	20-26
15785205-7	2005	MAb 5C8 detected all the known expression sites of full-size ACE using formalin-fixed and paraffin-embedded human tissues.	Paraffin	90-98	angiotensin I converting enzyme	Homo sapiens	61-64
15796387-3	2005	Immunohistochemical analysis of paraffin-embedded tissue sections showed that neoplastic cells in metastatic brain tumors, especially in cells that invaded blood vessels, exhibit intense heparanase immunoreactivity.	Paraffin	32-40	heparanase	Homo sapiens	187-197
15943037-3	2005	The aim of this study was to assess EGFR expression in human high-grade astrocytomas by means of immunohistochemistry on formalin-fixed, paraffin-embedded sections and to compare these findings with the results of our previous study on frozen sections from these tumours, in which we found about 60% EGFR positivity (10).	Paraffin	137-145	epidermal growth factor receptor	Homo sapiens	36-40
15742394-1	2005	AIM: To analyze the expression of retinoic acid receptor responder 3 (RARRES3) protein in paraffin-embedded tissues of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), and the correlation of RARRES3 production with tumor differentiation.	Paraffin	90-98	phospholipase A and acyltransferase 4	Homo sapiens	34-68
15742394-1	2005	AIM: To analyze the expression of retinoic acid receptor responder 3 (RARRES3) protein in paraffin-embedded tissues of hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC), and the correlation of RARRES3 production with tumor differentiation.	Paraffin	90-98	phospholipase A and acyltransferase 4	Homo sapiens	70-77
15682491-2	2005	METHODS: NF-kappaB activation was assayed by immunohistochemical staining in formalin-fixed, paraffin-embedded specimens from 45 gastric carcinoma patients.	Paraffin	93-101	nuclear factor kappa B subunit 1	Homo sapiens	9-18
16168125-5	2005	METHODS: We used immunohistochemistry to detect PDGFR-alpha overexpression on a series of 181 formalin-fixed paraffin-embedded invasive ductal breast carcinomas and in two breast cancer cell lines: MCF-7 and HS578T.	Paraffin	109-117	platelet derived growth factor receptor alpha	Homo sapiens	48-59
15654038-4	2005	APOE genotypes were determined by polymerase chain reaction of genomic DNA extracted from paraffin embedded tissue sections.	Paraffin	90-98	apolipoprotein E	Homo sapiens	0-4
15875732-0	2005	p53 alterations in sequential biopsies of Asian follicular lymphoma: a study of immunohistochemical staining pattern and gene mutations by PCR-SSCP in paraffin-embedded tissues.	Paraffin	151-159	tumor protein p53	Homo sapiens	0-3
15875732-3	2005	We aimed to investigate the frequency of p53 gene alterations in paraffin-embedded tissue using commercially available PCR-SSCP, and to correlate the results with P53 protein expression by immunohistochemistry.	Paraffin	65-73	tumor protein p53	Homo sapiens	41-44
15770300-4	2005	METHODS: The study was conducted in the year 2001 using polymerase chain reaction (PCR), to detect bcl-2 gene rearrangement in paraffin sections in 5 FL and 23 DLBCL cases diagnosed at the Department of Pathology at Jordan University of Science and Technology, Irbid, Jordan.	Paraffin	127-135	BCL2 apoptosis regulator	Homo sapiens	99-104
15762275-1	2005	Immunohistochemical analysis is used routinely to determine the estrogen receptor (ER) status of breast cancers in paraffin sections.	Paraffin	115-123	estrogen receptor 1	Homo sapiens	64-81
15762275-1	2005	Immunohistochemical analysis is used routinely to determine the estrogen receptor (ER) status of breast cancers in paraffin sections.	Paraffin	115-123	estrogen receptor 1	Homo sapiens	83-85
15613866-6	2005	Moreover, fluorescence in situ hybridization performed on paraffin-embedded tissue sections demonstrated an immunoglobulin heavy chain (IGH)/BCL2 translocation signal in both follicular and diffuse components, but an IGH/c-MYC translocation signal in only the diffuse component.	Paraffin	58-66	BCL2 apoptosis regulator	Homo sapiens	141-145
15987433-3	2005	METHODS: In this study c-erbB2 and topoisomerase IIalpha protein were evaluated by immunohistochemistry in formalin-fixed paraffin-embedded tissue from 225 samples of primary breast cancer, obtained between 1986 and 1998.	Paraffin	122-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	23-30
15681472-2	2005	We used DNA isolated from microdissected formalin-fixed, paraffin-embedded gastric tumors for mutation analysis of a region of the human gene for uracil-DNA glycosylase (UNG), encoding the UNG catalytic domain, and detected apparent base substitutions which, after further investigation, proved to be polymerase chain reaction (PCR) artifacts.	Paraffin	57-65	uracil DNA glycosylase	Homo sapiens	170-173
16227675-2	2005	To understand the expression of PDGF-A, PDGF-B and the beta-receptor (PDGF-Rbeta) in B cell lymphoproliferative disorders, we used an immunohistochemical method to stain formalin-fixed, paraffin-embedded tissues in 5 patients with reactive lymphoid hyperplasia, 15 with non-Hodgkin"s lymphoma and 23 with B cell chronic lymphocytic leukemia (B-CLL).	Paraffin	186-194	platelet derived growth factor receptor beta	Homo sapiens	70-80
16132618-5	2005	Using indirect immunoperoxidase staining of paraffin embedded sections, we observed the presence of FGF-2 in neurones, astrocytes, macrophages and endothelial cells.	Paraffin	44-52	fibroblast growth factor 2	Homo sapiens	100-105
16286910-6	2005	IHC for HER-2/neu was performed on paraffin sections of the core biopsy before treatment and the excised specimen following chemotherapy and scored as Negative (0-1+), 2+ and 3+.	Paraffin	35-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	8-17
15671552-2	2005	EXPERIMENTAL DESIGN: Cyclin D3 immunoreactivity was evaluated in 223 formalin-fixed and paraffin-embedded samples of LSCC patients with a mean follow-up of 62.8 +/- 43.2 months.	Paraffin	88-96	cyclin D3	Homo sapiens	21-30
16669252-3	2005	Two protocols allowing to avoid antigen heat unmasking procedure during demonstration of the NeuN neuronal label in paraffin sections by the light and confocal microscopy are presented.	Paraffin	116-124	RNA binding fox-1 homolog 3	Homo sapiens	93-97
15755011-1	2005	OBJECTIVE: To evaluate the expression of E-cadherin, a calcium-dependent cell adhesion molecule, in a retrospective analysis of paraffin-embedded tissue specimens of cervical squamous carcinoma and the relationship with histopathological differentiation and lymph node status.	Paraffin	128-136	cadherin 1	Homo sapiens	41-51
15589581-4	2005	METHODS: P16 expression was investigated by immunohistochemistry from paraffin-embedded tissue in 26 patients with leiomyoma, in 24 patients with STUMP, and in 21 patients with LMS.	Paraffin	70-78	cyclin dependent kinase inhibitor 2A	Homo sapiens	9-12
15589603-5	2005	METHODS: Immunohistochemical staining for c-KIT was performed on paraffin-embedded tissue blocks of 20 consecutive uterine specimens with carcinosarcoma, 40 with endometrial carcinoma, and 12 with atrophic endometrium.	Paraffin	65-73	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	42-47
16249809-7	2005	We also studied the IgH and bcl-2 (major breakpoint region=MBR) gene rearrangement on paraffin embedded samples with conventional PCR methods.	Paraffin	86-94	BCL2 apoptosis regulator	Homo sapiens	28-33
16006757-7	2005	METHODS: TIMP-1 or -2 was evaluated with avidin-biotin immunohistochemical staining from paraffin-embedded sections of primary breast carcinoma of 132 cases.	Paraffin	89-97	TIMP metallopeptidase inhibitor 1	Homo sapiens	9-21
15875085-4	2005	The expression of Ki-67 and EGFR protein was visualized on formalin fixed, paraffin embedded sections using immunohistochemistry (IHC).	Paraffin	75-83	epidermal growth factor receptor	Homo sapiens	28-32
16293973-4	2005	Immunohistochemical analysis of MKP-1 was performed on paraffin-embedded tissues.	Paraffin	55-63	dual specificity phosphatase 1	Homo sapiens	32-37
18035698-4	2005	In the present study, we have established methods for the detection of CD25 and the c-kit mutation D816V in paraffin-embedded bone marrow trephine biopsy specimen of 57 patients with various subtypes of mastocytoses and 239 controls.	Paraffin	108-116	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	84-89
16456730-1	2005	The aim of this study was to determine the expression of Bcl-2 gene and prognostic importance of Bcl-2 expression in paraffin embedded blocks of patients diagnosed with non-small cell lung cancer (NSCLC).	Paraffin	117-125	BCL2 apoptosis regulator	Homo sapiens	97-102
16477876-10	2005	All paraffin sections were found to contain lymphocytic infiltrations of CD43 and CD45RO phenotype in the tumor front.	Paraffin	4-12	sialophorin	Homo sapiens	73-77
15459092-0	2004	Additional data for oligonucleotide arrays of the p53 gene in DNA from formalin-fixed, paraffin-embedded tissue.	Paraffin	87-95	tumor protein p53	Homo sapiens	50-53
15386352-6	2004	The expression of TGF-beta(1) mRNA in 108 paraffin-embedded cervical carcinomas was detected by mRNA in situ hybridization.	Paraffin	42-50	transforming growth factor beta 1	Homo sapiens	18-29
21251403-2	2004	METHODS: Tbeta4 expression was detected in samples of 76 paraffin-embedded specimens with the neighboring noncancerous tissue using anti-Tbeta4 IgY antibody (primary antibody) by immunohistochemical staining.	Paraffin	57-65	thymosin beta 4 X-linked	Homo sapiens	9-15
15623594-3	2004	EXPERIMENTAL DESIGN: Mutational analysis of the kinase domain of EGFR coding sequence was done on 101 fresh frozen tumor tissues from patients without prior gefitinib treatment and 16 paraffin-embedded tumor tissues from patients treated with gefitinib.	Paraffin	184-192	epidermal growth factor receptor	Homo sapiens	65-69
15623599-8	2004	This is the first localization of all of the VIP/PACAP receptor subtypes in human formalin-fixed, paraffin-embedded tissues.	Paraffin	98-106	vasoactive intestinal peptide	Homo sapiens	45-48
15627062-2	2004	METHODS: The expression level and localization of S6K have been detected in formalin fixed, paraffin embedded sections of normal human breast tissues, adenomas and adenocarcinomas with different grade of differentiation.	Paraffin	92-100	ribosomal protein S6 kinase B2	Homo sapiens	50-53
15603096-3	2004	p53 Protein was detected in paraffin sections using the monoclonal p53 antibody.	Paraffin	28-36	tumor protein p53	Homo sapiens	0-3
15585136-9	2004	Immunohistochemical analysis revealed strong and diffuse KIT expression in each of the 16 paraffin-embedded sections examined.	Paraffin	90-98	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	57-60
15577317-2	2004	METHODS: The expression of p53 and Bcl-2 protein was assessed by immunohistochemistry from paraffin blocks.	Paraffin	91-99	tumor protein p53	Homo sapiens	27-30
15577317-2	2004	METHODS: The expression of p53 and Bcl-2 protein was assessed by immunohistochemistry from paraffin blocks.	Paraffin	91-99	BCL2 apoptosis regulator	Homo sapiens	35-40
15486938-5	2004	Paraffin-embedded liver tissue specimens were obtained from individuals who were homozygous for the Z (Glu342Lys), Mmalton (52Phe del), and Siiyama (Ser53Phe) alleles of alpha(1)-antitrypsin that result in hepatic inclusions and profound plasma deficiency.	Paraffin	0-8	serpin family A member 1	Homo sapiens	170-190
15469471-4	2004	CD10 was demonstrated in paraffin sections using the avidin-biotin immunoperoxidase technique.	Paraffin	25-33	membrane metalloendopeptidase	Homo sapiens	0-4
21244797-2	2004	METHODS: A rapid immunohistochemical method (streptoavidin-peroxidase, SP) was used to detect VEGF and CD44v6 proteins expression in 43 paraffin-embedded resected NSCLC tissues retrospectively.	Paraffin	136-144	vascular endothelial growth factor A	Homo sapiens	94-98
15596909-3	2004	In a retrospective study on patients with biopsy-proven diagnosis of meningioma, her-2/neu overexpression was evaluated using immunohistochemistry (IHC) performed on paraffin-embedded specimens.	Paraffin	166-174	erb-b2 receptor tyrosine kinase 2	Homo sapiens	81-90
15367415-2	2004	PATIENTS AND METHODS: The protein expression of E-cadherin was immunohistochemically evaluated in formalin-fixed, paraffin-embedded samples in 104 patients with primary ovarian carcinomas.	Paraffin	114-122	cadherin 1	Homo sapiens	48-58
15474538-3	2004	In this study, in situ hybridizations of whole-mount and paraffin sections of adult zebrafish brains, pituitaries, and ovarian follicles showed that CYP19A2 was strongly expressed in the olfactory bulb (OB), ventral telencephalon (TEL), preoptic area (POA), and ventral/caudal hypothalamic zone (HT) of the brain, and in the anterior and posterior lobes of the pituitary.	Paraffin	57-65	cytochrome P450, family 19, subfamily A, polypeptide 1b	Danio rerio	149-156
15523893-6	2004	In this study, p53 protein immunoreactivity was investigated in paraffin sections of primary nasopharyngeal tumors and metastatic cervical lymph nodes and association with clinical and histopathological characteristics was evaluated.	Paraffin	64-72	tumor protein p53	Homo sapiens	15-18
15646831-3	2004	Big ET-1 expression was evaluated in paraffin-embedded tissue sections from 10 NSCLC tumours using immunohistochemistry and in situ hybridisation.	Paraffin	37-45	endothelin 1	Homo sapiens	4-8
15355919-3	2004	EXPERIMENTAL DESIGN: COX-2 expression in normal colonic mucosa (n = 50), hyperplastic polyps (n = 43), sporadic adenomas (n = 67), and invasive colonic adenocarcinoma (n = 39) was studied in formalin-fixed and paraffin-embedded tissue sections from endoscopy biopsy and colonic resection specimens.	Paraffin	210-218	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	21-26
15648285-2	2004	Recently, a WT1 antibody raised against N-terminal 1-181 amino acids of human WT1 became commercially available for immunohistochemical use on paraffin-embedded tissue.	Paraffin	143-151	WT1 transcription factor	Homo sapiens	12-15
15648285-2	2004	Recently, a WT1 antibody raised against N-terminal 1-181 amino acids of human WT1 became commercially available for immunohistochemical use on paraffin-embedded tissue.	Paraffin	143-151	WT1 transcription factor	Homo sapiens	78-81
15648285-6	2004	WT1 immunostaining was performed on paraffin material using the WT1(6F-H2) antibody.	Paraffin	36-44	WT1 transcription factor	Homo sapiens	0-3
15488021-1	2004	Our previous studies indicate that glucose transporter 5 (GLUT5) is a microglial marker in routine paraffin sections, and is rarely present in monocytes/macrophages of the peripheral organs.	Paraffin	99-107	solute carrier family 2 member 5	Homo sapiens	35-56
15488021-1	2004	Our previous studies indicate that glucose transporter 5 (GLUT5) is a microglial marker in routine paraffin sections, and is rarely present in monocytes/macrophages of the peripheral organs.	Paraffin	99-107	solute carrier family 2 member 5	Homo sapiens	58-63
15510616-9	2004	The paraffin block of the one patient with a very high HER-2/neu serum level was also stained for HER-2/neu overexpression.	Paraffin	4-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	55-64
15510616-9	2004	The paraffin block of the one patient with a very high HER-2/neu serum level was also stained for HER-2/neu overexpression.	Paraffin	4-12	erb-b2 receptor tyrosine kinase 2	Homo sapiens	98-107
15246568-0	2004	Analysis of p53 mutations in cells taken from paraffin-embedded tissue sections of ductal carcinoma in situ and atypical ductal hyperplasia of the breast.	Paraffin	46-54	tumor protein p53	Homo sapiens	12-15
15337797-5	2004	The expression of BCL10 and NF-kappaB in pretreatment paraffin-embedded lymphoma tissues was evaluated by immunohistochemistry and confocal immunofluorescence microscopy.	Paraffin	54-62	nuclear factor kappa B subunit 1	Homo sapiens	28-37
15333784-2	2004	The distribution of AR was examined in paraffin-embedded tissue sections of the lower urogenital tract using 55 human embryos of 8-12 weeks of gestation.	Paraffin	39-47	androgen receptor	Homo sapiens	20-22
15300917-0	2004	Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma.	Paraffin	39-47	BCL2 apoptosis regulator	Homo sapiens	13-17
15300917-5	2004	Fluorescence in situ hybridization on paraffin-embedded tissue sections (T-FISH) identified a translocation of BCL2 with IGH gene.	Paraffin	38-46	BCL2 apoptosis regulator	Homo sapiens	111-115
15284539-5	2004	METHODS: MUC4 and ErbB2 receptor expression was localized by immunohistochemical studies using archival formalin-fixed and paraffin-embedded tissue.	Paraffin	123-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-23
15197780-2	2004	Expression of c-kit was examined immunohistochemically in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	74-82	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	14-19
15450303-1	2004	To investigate the relationship between the expression of cyclooxygenase-2 (COX-2), and invasive depth and angiogenesis in human transitional cell carcinoma (TCC), the expression of COX-2 and von Willebrand factor (vWF) was detected in paraffin-embedded transitional cell carcinoma specimens from 50 patients with histologically confirmed bladder transitional cell carcinoma.	Paraffin	236-244	prostaglandin-endoperoxide synthase 2	Homo sapiens	58-74
15551757-2	2004	We immunohistochemically demonstrated the expression and intracellular localization of FKHRL1 in human breast tumors by the novel anti-FKHRL1 antibody which is available for formalin-fixed paraffin-embedded specimens.	Paraffin	189-197	forkhead box O3	Homo sapiens	87-93
15551757-2	2004	We immunohistochemically demonstrated the expression and intracellular localization of FKHRL1 in human breast tumors by the novel anti-FKHRL1 antibody which is available for formalin-fixed paraffin-embedded specimens.	Paraffin	189-197	forkhead box O3	Homo sapiens	135-141
15247769-4	2004	MATERIALS AND METHODS: Caveolin-1 expression was evaluated by immunohistochemistry using rabbit polyclonal antibody against caveolin-1 in 60 paraffin embedded primary renal cell carcinoma specimens and 6 metastatic renal cell carcinoma specimens.	Paraffin	141-149	caveolin 1	Homo sapiens	23-33
15252319-11	2004	Electron microscopic studies performed on the paraffin-embedded renal tumor and formalin-fixed lung tumor revealed the typical rhomboid crystals of proto-renin.	Paraffin	46-54	renin	Homo sapiens	154-159
15245814-3	2004	METHODS: The immunohistochemical expression of HIF-1 alpha was evaluated in 93 formalin-fixed paraffin-embedded primary transitional cell carcinoma tissue samples.	Paraffin	94-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	47-58
15305981-4	2004	We have modified the paraffin-embedded tissue blot (PET blot), a technique combining immunohistochemistry (IHC), histoblot and Western blotting, for the detection of PrP(res) in paraffin sections in peripheral tissues in variant CJD.	Paraffin	21-29	prion protein	Homo sapiens	166-169
15305981-4	2004	We have modified the paraffin-embedded tissue blot (PET blot), a technique combining immunohistochemistry (IHC), histoblot and Western blotting, for the detection of PrP(res) in paraffin sections in peripheral tissues in variant CJD.	Paraffin	178-186	prion protein	Homo sapiens	166-169
15302512-5	2004	Immunohistochemistry was performed using a monoclonal mouse anti-AR antibody on paraffin-embedded tissue sections of tumors obtained from transurethral resection, radical cystectomy, or resection of metastases.	Paraffin	80-88	androgen receptor	Homo sapiens	65-67
15363317-1	2004	OBJECTIVE: To investigate the expression of EWS-FLI1/ERG fusion transcript resulting from t(11;12)(q24;12) in paraffin-embedded tissues and its diagnostic implication for Ewing"s sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET).	Paraffin	110-118	ETS transcription factor ERG	Homo sapiens	53-56
15363317-2	2004	METHODS: One-step reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to detect a characteristic EWS-FLI1/ERG fusion transcript in 25 cases of ES/pPNET and 15 cases of other small round cell tumors (including 8 cases of rhabdomyosarcoma, 4 cases of synovial sarcoma, 2 cases of neuroblastoma and 1 case of lymphoma) using formalin-fixed and paraffin-embedded tissues.	Paraffin	359-367	ETS transcription factor ERG	Homo sapiens	124-127
15363320-0	2004	[Application of immunohistochemistry-laser microdissection-PCR technique in detecting p53 gene mutation in paraffin sections of gastric cancer].	Paraffin	107-115	tumor protein p53	Homo sapiens	86-89
15363320-2	2004	METHODS: The expression of p53 protein in 41 paraffin-embedded advanced gastric cancer samples was assessed by immunohistochemistry.	Paraffin	45-53	tumor protein p53	Homo sapiens	27-30
15363320-12	2004	CONCLUSIONS: IHC-LMD-PCR technique can be successfully applied in paraffin sections of gastric cancers for the detection of p53 gene mutations.	Paraffin	66-74	tumor protein p53	Homo sapiens	124-127
15183529-3	2004	In this study, the expression of phosphorylated Akt at Thr308 and Ser473, BCL-2-antagonist of cell death (BAD) at Ser136 and glycogen synthase kinase-3beta (GSK-3beta) at Ser9 in 47 paraffin-embedded human colorectal carcinoma (CRC) tissues were determined by immunohistochemical staining in order to dissect the alterations in the signal transduction pathways in CRC.	Paraffin	182-190	AKT serine/threonine kinase 1	Homo sapiens	48-51
15248926-2	2004	The purpose of this study was to evaluate the relationship of the cisplatin sensitivity/prognosis with the expression of excision repair cross complement-1 (ERCC-1), metallothionein (MT), and p53 in the paraffin-embedded tissue of advanced non-small cell lung cancer (NSCLC).	Paraffin	203-211	tumor protein p53	Homo sapiens	192-195
15213596-6	2004	We have evaluated the immunohistochemical expression of p16 in a series of formalin-fixed, paraffin-embedded vulvar carcinomas and their putative precursors.	Paraffin	91-99	cyclin dependent kinase inhibitor 2A	Homo sapiens	56-59
15240539-3	2004	EXPERIMENTAL DESIGN: A(3)AR mRNA expression in various tumor tissues was tested in paraffin-embedded slides using reverse transcription-PCR analysis.	Paraffin	83-91	adenosine A3 receptor	Homo sapiens	21-27
15168356-4	2004	Double immunostainings for CD34 and Ki-67 can be used on paraffin-embedded tissue to determine the endothelial proliferation fraction.	Paraffin	57-65	CD34 molecule	Homo sapiens	27-31
15208356-0	2004	Immunohistochemical detection of EGFR in paraffin-embedded tumor tissues: variation in staining intensity due to choice of fixative and storage time of tissue sections.	Paraffin	41-49	epidermal growth factor receptor	Homo sapiens	33-37
15454013-2	2004	METHODS: ADAM8 and ADAM12 was detected by immunohistochemistry (SP) in 40 paraffin-embedded specimens of central giant cell lesions of jaw, 10 peripheral giant cell lesions, 9 cherubisms, 6 aneurysmal bone cysts.	Paraffin	74-82	ADAM metallopeptidase domain 12	Homo sapiens	19-25
15227730-3	2004	The expression status of RAR-beta in cancer cells and adjacent normal appearing bronchial epithelium from 39 patients, diagnosed as stage I NSCLC and undergone a curative lung resection, was analyzed in paraffin-embedded tissue sections by IHC staining.	Paraffin	203-211	retinoic acid receptor beta	Homo sapiens	25-33
14749257-5	2004	Immunohistochemistry on sections of paraffin-embedded rat kidneys showed a distribution of AE2a/AE2b labeling in the kidney similar to the distribution of AE2 in the rat kidney reported previously.	Paraffin	36-44	solute carrier family 4 member 2	Rattus norvegicus	91-94
21232219-2	2004	METHODS: c-kit protein expression was detected in 52 formalin-fixed and paraffin-embedded SCLC, 20 non-small cell lung cancer (NSCLC) and 10 normal lung tissues by immunohistochemistry with rabbit antibody to human c-kit protein.	Paraffin	72-80	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-14
15192961-8	2004	Immunohistochemical staining using paraffin-embedded tissue revealed intraluminal tumor cells expressing leukocyte common antigen and CD20 but not CD3.	Paraffin	35-43	keratin 20	Homo sapiens	134-138
15201505-4	2004	From 1998 to 2002, using CISH and IHC, the amplification and protein expression of the HER-2/neu oncogene were examined using paraffin sections in 130 breast carcinomas and to determine the prognostic role of HER-2/neu for outcome after a follow-up of 24- 64 months.	Paraffin	126-134	erb-b2 receptor tyrosine kinase 2	Homo sapiens	87-96
15171988-0	2004	The use of proliferating cell nuclear antigen immunohistochemistry with a unique functional marker to detect postnatal neurogenesis in paraffin-embedded sections of the mature pig brain.	Paraffin	135-143	proliferating cell nuclear antigen	Sus scrofa	11-45
15239399-5	2004	Results of immunohistochemical analysis of paraffin-embedded specimens were positive for cyclin D1 and Bcl2 in the tumor cells.	Paraffin	43-51	BCL2 apoptosis regulator	Homo sapiens	103-107
15269478-6	2004	MATERIALS AND METHODS: p53 protein expression was evaluated on formalin-fixed paraffin-embedded sections using streptavidin biotin immunoperoxidase technique after high temperature antigen retrieval.	Paraffin	78-86	tumor protein p53	Homo sapiens	23-26
15099948-3	2004	Demonstration of p53 polymorphism was performed in DNA extracted from paraffin-embedded sections using the polymerase chain reaction (PCR).	Paraffin	70-78	tumor protein p53	Homo sapiens	17-20
15131052-2	2004	EXPERIMENTAL DESIGN: Immunohistochemistry was performed on paraffin-embedded sections by using rabbit antiserum against COX-2.	Paraffin	59-67	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	120-125
15131054-4	2004	EXPERIMENTAL DESIGN: Ep-CAM expression was examined immunohistochemically on paraffin-embedded tissue specimens from 99 patients who underwent surgical treatment for gallbladder carcinoma in the period between August 1988 and May 1999.	Paraffin	77-85	epithelial cell adhesion molecule	Homo sapiens	21-27
15100248-0	2004	C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections.	Paraffin	65-73	KIT proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	0-5
15113851-5	2004	METHODS: KIT expression was evaluated by means of immunohistochemistry in paraffin wax embedded sections from 67 tissue samples.	Paraffin	74-86	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	9-12
15138929-2	2004	We examined the immunoreactivity of Foxa2 in paraffin sections of 75 lung tumors: 17 typical carcinoids, 2 atypical carcinoids, 4 large cell neuroendocrine (NE) carcinomas, 23 small cell carcinomas, 19 adenocarcinomas, 7 squamous cell carcinomas, and 3 (non-NE) large cell carcinomas, using a polyclonal rabbit Foxa2 antibody and a biotin-streptavidin detection system.	Paraffin	45-53	forkhead box A2	Homo sapiens	36-41
15100248-0	2004	C-kit gene product (CD117) immunoreactivity in canine and feline paraffin sections.	Paraffin	65-73	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	20-25
15100248-2	2004	To evaluate the pattern of CD117 expression in dogs and cats, we applied a polyclonal antibody on paraffin sections from 44 samples of normal tissues and 104 tumors.	Paraffin	98-106	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	27-32
15182488-6	2004	The expression of iNOS protein in the paraffin-embedded lung sections was measured with streptavidin/peroxidase (SP) immunohistochemistry on tissue microarray and quantified by Image-Pro Plus.	Paraffin	38-46	nitric oxide synthase 2	Rattus norvegicus	18-22
15129118-5	2004	METHODS: Immunohistochemical analysis for transforming growth factor-beta1 and glial cell line-derived neurotrophic factor and their receptors TbetaR II, GFRalpha-1, and Ret was performed on formalin-fixed, paraffin-embedded archival surgical specimens.	Paraffin	207-215	glial cell derived neurotrophic factor	Homo sapiens	79-122
15338868-2	2004	METHODS: Immunohistochemistry staining (PicTure two steps method) was used to detect connexin 43 and E-cadherin expression in 60 paraffin-embedded laryngeal carcinomas and 10 normal epithelia around tumors.	Paraffin	129-137	cadherin 1	Homo sapiens	101-111
15041112-4	2004	p53 immunostaining was performed on paraffin-embedded tissues using monoclonal antibody DO7 and an automated immunostainer.	Paraffin	36-44	tumor protein p53	Homo sapiens	0-3
15080298-1	2004	We studied expression of vascular endothelial growth factor (VEGF) in paraffin-embedded bone marrow sections obtained from 15 patients with chronic myeloid leukemia (CML) in chronic phase (CP), 3 in accelerated phase (AP), 7 in myeloid blast phase (BP(M)), 6 in lymphoid blast phase (BP(L)), and in 3 normal bone marrow samples.	Paraffin	70-78	vascular endothelial growth factor A	Homo sapiens	25-59
15080298-1	2004	We studied expression of vascular endothelial growth factor (VEGF) in paraffin-embedded bone marrow sections obtained from 15 patients with chronic myeloid leukemia (CML) in chronic phase (CP), 3 in accelerated phase (AP), 7 in myeloid blast phase (BP(M)), 6 in lymphoid blast phase (BP(L)), and in 3 normal bone marrow samples.	Paraffin	70-78	vascular endothelial growth factor A	Homo sapiens	61-65
15073595-2	2004	EGFR expression was investigated in paraffin sections of resection specimens of 89 gastric carcinomas from Mexican Mestizo patients using standardized immunohistochemistry with antigen retrieval (Dako EGFRpharmDx assay detection system).	Paraffin	36-44	epidermal growth factor receptor	Homo sapiens	0-4
15190803-2	2004	METHODS: Expression of P16 and nm23 proteins was examined by SABC immunohistochemical method in 39 cases of paraffin blocks of normal salivary gland tissues and salivary gland tumors.	Paraffin	108-116	cyclin dependent kinase inhibitor 2A	Homo sapiens	23-26
15054739-4	2004	METHODS: MUC4 antigens and ErbB2 receptor expression are localized by immunohistochemical studies that use archival formalin-fixed and paraffin-embedded tissue.	Paraffin	135-143	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-32
15010889-4	2004	To further investigate the molecular mechanisms underlying bladder carcinogenesis with this specific etiology, mutation analysis of p53 gene (exon 5-8) was performed for 11 and 18 paraffin-embedded bladder cancers in Ukrainians, respectively collected before and after the Chernobyl disaster.	Paraffin	180-188	tumor protein p53	Homo sapiens	132-135
15051039-7	2004	Bcl-2 expression was investigated by immunohistochemistry from paraffin-embedded tissue.	Paraffin	63-71	BCL2 apoptosis regulator	Homo sapiens	0-5
15010841-0	2004	Detection of (NAD(P)H:Quinone oxidoreductase-1, EC 1.6.99.2) 609C--&gt;T and 465C--&gt;T polymorphisms in formalin-fixed, paraffin-embedded human tumour tissue using PCR-RFLP.	Paraffin	122-130	NAD(P)H quinone dehydrogenase 1	Homo sapiens	14-46
15010841-4	2004	This study describes a method that is suitable for analysing NQO1 polymorphisms in genomic DNA isolated from formalin-fixed paraffin-embedded tissue.	Paraffin	124-132	NAD(P)H quinone dehydrogenase 1	Homo sapiens	61-65
15161050-5	2004	Good correlation was found between percentages of ER-positive cells in LSC and by image analysis in paraffin-embedded sections (r=0.59, p&lt;0.001).	Paraffin	100-108	estrogen receptor 1	Homo sapiens	50-52
15028026-0	2004	Detection of glyceraldehyde 3-phosphate dehydrogenase messenger RNA using a peptide nucleic acid probe in paraffin-embedded archival specimens.	Paraffin	106-114	glyceraldehyde-3-phosphate dehydrogenase	Homo sapiens	13-53
15043789-4	2004	In situ hybridization (ISH) was used to demonstrate the expression of hTR in 55 cases of paraffin-embedded sebaceous carcinoma of the eyelid, and the results were compared with the proliferative index determined by Mib-1 immuno-labeling, histological patterns and recurrence of the tumor.	Paraffin	89-97	telomerase RNA component	Homo sapiens	70-73
15041052-2	2004	METHODS: The expression of E-cadherin, CD44s, and CD44v6, was evaluated immunohistochemically using monoclonal antibodies against epitopes of standard and variant proteins, in paraffin-embedded mesopharyngeal cancer tissues from 57 patients who had received curative therapy.	Paraffin	176-184	cadherin 1	Homo sapiens	27-37
21211185-2	2004	METHODS: The expression of heparanase was assessed in 122 paraffin-embedded specimens and 38 freshly-taken tissues by immunohistochemical staining and Western blot.	Paraffin	58-66	heparanase	Homo sapiens	27-37
14726466-0	2004	Evaluation of oligonucleotide arrays for sequencing of the p53 gene in DNA from formalin-fixed, paraffin-embedded breast cancer specimens.	Paraffin	96-104	tumor protein p53	Homo sapiens	59-62
14726466-2	2004	The purpose of this study was to determine whether a p53 microarray could be used to sequence the p53 gene in DNA extracted from formalin-fixed, paraffin-embedded (FFPE) tissues.	Paraffin	145-153	tumor protein p53	Homo sapiens	98-101
14712499-8	2004	Immunohistochemical analysis of a limited series (n = 8) of paraffin-embedded breast cancers indicated that the level of CD46 protein expression directly associates with that of the mRNA and, where prominent, is localized in the tumor epithelial cell population, including at the plasma membrane.	Paraffin	60-68	CD46 molecule	Homo sapiens	121-125
14968440-5	2004	NEP gene expression was monitored by RT-PCR, NEP mRNA was detected in paraffin tissue sections and cultured cells of human prostate by the highly sensitive method of one step-in situ reverse transcriptase-polymerase chain reaction (RT-PCR).	Paraffin	70-78	membrane metalloendopeptidase	Homo sapiens	45-48
15038405-5	2004	PATIENTS AND METHODS: Bcl-2 expression was investigated using immunohistochemical techniques on paraffin-embedded tissue from 21 patients with uterine LMS.	Paraffin	96-104	BCL2 apoptosis regulator	Homo sapiens	22-27
15163002-3	2004	EGFR gene amplification and chromosome 7 aneuploidy was detected in 34 formalin-fixed, paraffin-embedded benign and malignant gliomas by chromogenic in situ hybridization (CISH) using digoxigenin-labeled EGFR and biotin-labeled chromosome 7 centromeric probes.	Paraffin	87-95	epidermal growth factor receptor	Homo sapiens	0-4
15101720-2	2004	We reviewed the diagnosis of 48 patients with FL and investigated the type of bcl-2 gene rearrangement using DNA from paraffin-embedded tumor samples obtained at the time of diagnosis.	Paraffin	118-126	BCL2 apoptosis regulator	Homo sapiens	78-83
14983936-1	2004	We performed a comprehensive immunohistochemical evaluation of claudin 4 protein expression in paraffin-embedded tissue samples from 72 patients with primary infiltrating pancreatic cancer, 38 patients with metastatic pancreatic cancer, and a panel of normal control tissue samples from various organs.	Paraffin	95-103	claudin 4	Homo sapiens	63-72
15043312-10	2004	Positivity for JAZF1-JJAZ1 fusion transcripts was found in four of 10 fresh-frozen samples and in one of five paraffin-embedded ESTs.	Paraffin	110-118	JAZF zinc finger 1	Homo sapiens	15-20
14871971-3	2004	EXPERIMENTAL DESIGN: Unstained sections of paraffin-embedded tumor samples were stained with p185/HER2 receptor antibody.	Paraffin	43-51	erb-b2 receptor tyrosine kinase 2	Homo sapiens	98-102
15328914-2	2004	Squamous carcinoma and carcinoma in situ from the female genital tract were examined for the expression of p16 by paraffin immunohistochemistry.	Paraffin	114-122	cyclin dependent kinase inhibitor 2A	Homo sapiens	107-110
15033020-4	2004	The expression of iNOS protein in paraffin-embedded lung sections with Streptavidin/peroxidase (SP) immunohistochemistry were measured by tissue microarray and Image-Pro Plus.	Paraffin	34-42	nitric oxide synthase 2	Rattus norvegicus	18-22
15041817-5	2004	Mast cell tissular infiltration can be identified on paraffin sections by tryptase or CD117 (c-kit) immuno-staining.	Paraffin	53-61	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	86-91
15253134-4	2004	The EGFR expression was visualized in formalin-fixed, paraffin-embedded sections, using immunohistochemistry.	Paraffin	54-62	epidermal growth factor receptor	Homo sapiens	4-8
14760079-3	2004	EXPERIMENTAL DESIGN: Immunohistochemistry for moesin monoclonal antibody was performed on 103 paraffin-embedded specimens from patients with primary OSCC, including 30 patients with locoregional lymph node metastasis, and in the sections from nude mice transplanted with two cell lines derived from a single human tongue cancer (SQUU-A and SQUU-B).	Paraffin	94-102	moesin	Homo sapiens	46-52
15318940-2	2004	METHODS: We assessed Her-2/neu alteration using CISH on formalin-fixed paraffin-embedded primary invasive ductal carcinoma tumors in which IHC (CB11 antibody) had previously been performed, and we compared the results with IHC.	Paraffin	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-26
15318940-2	2004	METHODS: We assessed Her-2/neu alteration using CISH on formalin-fixed paraffin-embedded primary invasive ductal carcinoma tumors in which IHC (CB11 antibody) had previously been performed, and we compared the results with IHC.	Paraffin	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-30
15041817-5	2004	Mast cell tissular infiltration can be identified on paraffin sections by tryptase or CD117 (c-kit) immuno-staining.	Paraffin	53-61	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	93-98
14631380-0	2004	Evaluation of the predictive value of Her-2/neu gene expression on osteosarcoma therapy in laser-microdissected paraffin-embedded tissue.	Paraffin	112-120	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-47
14694519-5	2004	In paraffin sections, cells that expressed IL-6 or MCP-1 were identified by combined in situ hybridization and immunohistochemistry.	Paraffin	3-11	interleukin 6	Homo sapiens	43-47
15188024-5	2004	TTF-1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues.	Paraffin	60-68	NK2 homeobox 1	Homo sapiens	0-5
15648603-3	2004	The present study evaluates the amplification of HER-2/neu gene in paraffin sections from 42 cases of Ewing"s sarcoma by a real-time quantitative polymerase reaction method using LightCycler system (Roche diagnostics, GmbH Mannheim, Germany).	Paraffin	67-75	erb-b2 receptor tyrosine kinase 2	Homo sapiens	49-58
14687488-2	2003	METHODS: HIF-1alpha protein expression was determined by immunohistochemistry in formalin-fixed and paraffin-embedded specimens obtained from 13 cases of NP, 28 cases of BPH, and 34 cases of Pca.	Paraffin	100-108	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
15192305-9	2004	Immunohistochemistry using anti-PGF antibody on the paraffin blocks from lung cancer patients showed that PGF expression was significantly higher in SCLC than NSCLC tissue sections (32 vs. 5.6%, p = 0.041, Fisher"s exact test).	Paraffin	52-60	placental growth factor	Homo sapiens	32-35
13680221-4	2004	Immunohistochemical study for COX-2 was carried out using formalin-fixed paraffin-embedded tissues.	Paraffin	73-81	prostaglandin-endoperoxide synthase 2	Homo sapiens	30-35
14693064-4	2003	METHODS: Immunohistochemical assay with the LSAB immunostaining technique was used to determine protein expression of P-gp and LRP in the specimens of paraffin-embedded tissues from 151 cases of breast carcinoma and 40 normal breast tissues (control).	Paraffin	151-159	ATP binding cassette subfamily B member 1	Homo sapiens	118-122
14520710-4	2003	AKT expression was investigated by immunohistochemistry in sections from 56 paraffin-embedded prostate specimens displaying benign prostatic tissue (BPT), prostatic intraepithelial neoplasia (PIN), and primary tumors graded 2-5 according to Gleason.	Paraffin	76-84	AKT serine/threonine kinase 1	Homo sapiens	0-3
14669341-2	2003	METHODS: P-gp was stained with streptavidin-peroxidase complex immunohistochemical method in routine paraffin-embedded sections of gallbladder carcinomas.	Paraffin	101-109	ATP binding cassette subfamily B member 1	Homo sapiens	9-13
14632806-3	2003	Expression of a paraffin-reactive p16INK4a marker has recently been shown to increase in cervical squamous neoplasms as lesions progress from low-grade dysplasia to squamous cell carcinoma in situ.	Paraffin	16-24	cyclin dependent kinase inhibitor 2A	Homo sapiens	34-42
14613648-9	2003	(3) In 42 paraffin-embedded GCT specimens, the positive expression rates of NOS1, NOS2, and NOS3 protein were 85.7%, 59.5%, and 31.0% in MGC, 54.8%, 28.6%, and 14.3% in MC, respectively.	Paraffin	10-18	nitric oxide synthase 3	Homo sapiens	92-96
14682475-3	2003	METHODS: c-erbB-2 protein over-expression was studied immunohistochemically (IHC) in 68 paraffin-embedded thyroid tumors (12 follicular adenomas, 20 papillary carcinomas, 20 follicular carcinomas, eight medullary carcinomas, eight anaplastic carcinomas), diagnosed at the Pathology Department of Cukurova University.	Paraffin	88-96	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-17
14602487-6	2003	METHODS: We studied the expression of Cox-2 by immunohistochemistry in 106 primary breast carcinoma specimens collected over a three-year period, using a commercially available polyclonal antibody on formalin-fixed, paraffin-embedded tissue.	Paraffin	216-224	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
14615822-11	2003	Recently the demonstration of CD 99 and CD 117, which can now be done on paraffin sections, may be useful to identify blasts of granulocytic origin.	Paraffin	73-81	CD99 molecule (Xg blood group)	Homo sapiens	30-35
14652816-2	2003	We have examined immunohistochemical PCDGF expression in 206 paraffin-embedded human breast lesions and investigated its association with clinicopathological variables.	Paraffin	61-69	granulin precursor	Homo sapiens	37-42
12973686-4	2003	We examined qualitatively and semi-quantitatively the immunohistochemical expression of trypsin and TATI on paraffin-embedded serial tissue sections from 91 colorectal adenocarcinomas.	Paraffin	108-116	serine peptidase inhibitor Kazal type 1	Homo sapiens	100-104
14568798-7	2003	INTERVENTIONS: Expression of VEGF-A and VEGF-C was determined by immunohistochemistry on formalin-fixed, paraffin-embedded biopsy specimens.	Paraffin	105-113	vascular endothelial growth factor A	Homo sapiens	29-35
14506673-4	2003	The results obtained in the ER immunocytochemical assay on aspirates and paraffin sections using the antibody SP1 and those obtained on paraffin sections using the antibody 6F11 were quite similar.	Paraffin	73-81	estrogen receptor 1	Homo sapiens	28-30
14507575-5	2003	METHODS: Leu-7 was studied immunohistochemically in paraffin-embedded specimens from 55 human autopsied hearts (mean age 69 years, range 42-94 years, 34 males, 21 females).	Paraffin	52-60	beta-1,3-glucuronyltransferase 1	Homo sapiens	9-14
14514922-4	2003	METHODS: The expression of Wnt2, Wnt5a, Wnt5b, Wnt7b, and Wnt10b was defined by in situ, antisense RNA hybridisation of paraffin wax embedded sections of benign naevi and malignant melanoma.	Paraffin	120-132	Wnt family member 10B	Homo sapiens	58-64
12886520-4	2003	Caspase-3 levels in formalin-fixed, paraffin-embedded specimens were quantified using immunohistochemical detection and video image analysis.	Paraffin	36-44	caspase 3	Homo sapiens	0-9
14666713-3	2003	MATERIALS AND METHODS: Overexpression of VEGF was evaluated in 202 archival paraffin-embedded tissue specimens using an avidin-biotin immunohistochemical (IHC) assay.	Paraffin	76-84	vascular endothelial growth factor A	Homo sapiens	41-45
14572158-2	2003	The expression of VEGF and MVD was assessed on tissue sections formalin-fixed and paraffin-embedded by immunohistochemical staining using anti-VEGF antibody of human origin and anti-CD34 monoclonal antibody.	Paraffin	82-90	vascular endothelial growth factor A	Homo sapiens	18-22
14562283-6	2003	An immunohistochemical study of p53 expression was performed on paraffin-embedded tissue.	Paraffin	64-72	tumor protein p53	Homo sapiens	32-35
12930346-1	2003	Described here is the use of detecting TLS/FUS-CHOP fusion transcripts to confirm the diagnosis of a myxoid liposarcoma by nested reverse transcription-polymerase chain reaction assay using archival formalin-fixed, paraffin-embedded tissues of a young man with a benign-looking myxoid tumor on his upper extremity, which is often misdiagnosed clinically or histopathologically as a benign tumor.	Paraffin	215-223	FUS RNA binding protein	Homo sapiens	39-42
14582702-6	2003	The expression of the COX-2 protein was immunohistochemically examined on formalin-fixed and paraffin-embedded tissue sections using an anti-COX-2 antibody and an avidin-biotin complex method.	Paraffin	93-101	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12970315-3	2003	We analyzed exons 11 and 15 of BRAF gene in six human thyroid cancer cell lines and 207 paraffin-embedded thyroid tumor tissues.	Paraffin	88-96	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	31-35
12767065-5	2003	In an independent and blinded fashion, HER 2/neu expression was assessed in paraffin sections from 139 of the tumor specimens using the HercepTest kit.	Paraffin	76-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-44
12930690-1	2003	OBJECTIVE: To detect the PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded rhabdomyosarcoma tissues by one-step RT-PCR and discuss its diagnostic potential.	Paraffin	87-95	paired box 3	Homo sapiens	25-29
12930690-1	2003	OBJECTIVE: To detect the PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded rhabdomyosarcoma tissues by one-step RT-PCR and discuss its diagnostic potential.	Paraffin	87-95	forkhead box O1	Homo sapiens	44-48
12902879-5	2003	Testing for Her-2/neu overexpression was performed on paraffin-embedded archival tumor tissue using immunohistochemistry (IHC) (Hercep test).	Paraffin	54-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	12-21
14506948-6	2003	BSP protein expression was evaluated by the immunophosphatase technique using a BSP polyclonal antibody in paraffin-embedded cervical biopsies.	Paraffin	107-115	integrin binding sialoprotein	Homo sapiens	0-3
12838316-3	2003	The expression of RARRES3 protein in 151 paraffin-embedded colorectal tissues (11 distal normal mucosa, 20 adenoma and 120 colorectal adenocarcinoma) was determined by immunohistochemistry.	Paraffin	41-49	phospholipase A and acyltransferase 4	Homo sapiens	18-25
12829666-10	2003	RESULTS: These results were extended by developing a fluorescent-based quantitative immunocytochemistry technique to assess the levels of CYP3A4/5 in 18 paraffin-embedded primary biopsy sections.	Paraffin	153-161	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	138-144
12823708-4	2003	METHODS AND RESULTS: The immunohistochemical expression of p57kip2 protein was investigated using paraffin-embedded tissue sections in histologically unequivocal cases of CHM (n = 51), PHM (n = 7), invasive mole (n = 1), and hydropic miscarriage (n = 2), as well as in histologically undetermined cases (n = 9).	Paraffin	98-106	cyclin dependent kinase inhibitor 1C	Homo sapiens	59-66
12787041-3	2003	METHODS: The expression of moesin was evaluated immunohistochemically in paraffin-embedded tissues of 59 specimens of OSCC, 35 specimens of OED, 17 specimens of VC, and five specimens of normal oral epithelium.	Paraffin	73-81	moesin	Homo sapiens	27-33
12696066-10	2003	Immunohistochemical staining of paraffin sections from six cases demonstrated expression of JUNB protein in five cases and BCL2 in three cases.	Paraffin	32-40	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-96
12796027-4	2003	CD117 overexpression was evaluated using immunohistochemistry (A4052 polyclonal antibody) performed on archival paraffin-embedded specimens.	Paraffin	112-120	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
12734658-4	2003	In the present study, we screened paraffin-embedded brain tissue from different areas of 18 cases (8 autopsy cases and 10 biopsies) for alterations in the TP53 and PTEN genes.	Paraffin	34-42	tumor protein p53	Homo sapiens	155-159
12696066-10	2003	Immunohistochemical staining of paraffin sections from six cases demonstrated expression of JUNB protein in five cases and BCL2 in three cases.	Paraffin	32-40	BCL2 apoptosis regulator	Homo sapiens	123-127
12754286-5	2003	Here we report the application of a tyramine/CARD (catalyzed reporter deposition)-enhanced nonradioactive in situ hybridization (ISH) protocol for detection of catalase mRNA in sections of perfusion-fixed, paraffin-embedded rat brain.	Paraffin	206-214	catalase	Rattus norvegicus	160-168
12754286-8	2003	In parallel IHC experiments, using an antigen retrieval method consisting of combined trypsin digestion and microwave treatment of paraffin sections, the catalase antigen was found as distinct cytoplasmic granules in most catalase mRNA-positive neurons.	Paraffin	131-139	catalase	Rattus norvegicus	154-162
12753718-4	2003	METHODS: The expression of MTS1 and E-cadherin were detected by SP immunohistochemical technique in 54 paraffin-embedded tissue specimens of breast cancer.	Paraffin	103-111	cyclin dependent kinase inhibitor 2A	Homo sapiens	27-31
12753718-4	2003	METHODS: The expression of MTS1 and E-cadherin were detected by SP immunohistochemical technique in 54 paraffin-embedded tissue specimens of breast cancer.	Paraffin	103-111	cadherin 1	Homo sapiens	36-46
12707028-8	2003	In addition, the mRNA levels of cyclin D1 and Stat 3 were determined by quantitative real-time reverse transcriptase-polymerase chain reaction of paraffin-embedded microdissected tissue.	Paraffin	146-154	signal transducer and activator of transcription 3	Homo sapiens	46-52
12649669-5	2003	In this study, c-kit immunoreactivity was evaluated on paraffin sections of 72 endometrial adenocarcinomas (57 endometrioid, 10 serous, and 5 clear cell) with a polyclonal antibody.	Paraffin	55-63	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	15-20
12894514-3	2003	Her2/neu levels were immunohistochemically detected on formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her2/neu Oncoprotein Ab-17 monoclonal antibody(mAb).	Paraffin	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
12894514-3	2003	Her2/neu levels were immunohistochemically detected on formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her2/neu Oncoprotein Ab-17 monoclonal antibody(mAb).	Paraffin	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	5-8
12894514-3	2003	Her2/neu levels were immunohistochemically detected on formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her2/neu Oncoprotein Ab-17 monoclonal antibody(mAb).	Paraffin	71-79	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
12944180-1	2003	Aberrant p53 protein accumulation was measured immunohistologically in 342 colorectal paraffin-embedded tissue sections from 115 patients (24 with adenocarcinoma, 59 with adenoma and 32 "hospital controls").	Paraffin	86-94	tumor protein p53	Homo sapiens	9-12
12725433-4	2003	Using immunohistochemical techniques on paraffin-embedded tissue we have successfully shown that CgA is selectively expressed in ciliated cells of the bovine oviduct.	Paraffin	40-48	chromogranin A	Bos taurus	97-100
26680921-4	2003	MATERIALS AND METHODS: We compared the immunohistochemistry (IHC) detection of Her-2/neu overexpression, with differential polymerase chain reaction (PCR) to assess the gene amplification of the Her-2/ neu, in 163 cases of invasive ductal carcinoma of the breast using paraffin-embedded tissue.	Paraffin	269-277	erb-b2 receptor tyrosine kinase 2	Homo sapiens	195-205
12841678-7	2003	p53 protein accumulation was determined by immunohistochemistry on paraffin-embedded tumor specimens from 58/71 samples available for this study.	Paraffin	67-75	tumor protein p53	Homo sapiens	0-3
12926141-3	2003	MATERIALS AND METHODS: Expression of u-PA protein was investigated immunohistochemically on paraffin-embedded section from 61 patients with untreated prostate cancer.	Paraffin	92-100	plasminogen activator, urokinase	Homo sapiens	37-41
12714894-3	2003	HER-2/neu overexpression was evaluated using immunohistochemistry (IHC) performed on paraffin-embedded specimens.	Paraffin	85-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-9
12629411-5	2003	E-cadherin expression was evaluated by immunostaining on formalin fixed, paraffin embedded tissue sections using anti E-cadherin murine monoclonal antibody, HECD1 and standard avidin-biotin immunoperoxidase complex technique.	Paraffin	73-81	cadherin 1	Homo sapiens	0-10
12532420-5	2003	The mutation status of exons 5-8 of p53 was analyzed by denaturing high pressure liquid chromatography (DHPLC) in formalin-fixed, paraffin-embedded tumor sections, followed by direct sequencing of cases with aberrant chromatographic patterns.	Paraffin	130-138	tumor protein p53	Homo sapiens	36-39
12690299-3	2003	Expression of c-kit was analysed in 57 paraffin-embedded sections of choroidal melanoma specimens and three choroidal melanoma cell lines using immunochemistry and Western blotting.	Paraffin	39-47	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	14-19
12715168-5	2003	Her2/neu was immunohistochemically detected on sections from formalin-fixed, paraffin-embedded tissues using c-erbB-2/Her-2/neu oncoprotein Ab-17 monoclonal antibody (mAb).	Paraffin	77-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
12648880-4	2003	P53 expression was detected in paraffin-embedded endometrial specimens by immunohistochemical methods.	Paraffin	31-39	tumor protein p53	Homo sapiens	0-3
12637466-3	2003	HER2 gene amplification (HER2_AMP) was evaluated by fluorescence in situ hybridization (FISH; Ventana Medical Systems HER-2/neu probe; Tucson, AZ), and HER2 protein overexpression (HER2_EXP) was evaluated by immunohistochemistry (IHC; Oncogene Science antibody Ab-3; Cambridge, MA) on parallel-cut formalin-fixed paraffin-embedded tissue sections.	Paraffin	313-321	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
12633561-3	2003	METHOD: Expression of COX-2 in 67 stage 1 NSCLC paraffin-embedded tumor samples was determined by immunohistochemistry (IHC).	Paraffin	48-56	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	22-27
12598308-3	2003	Here we describe a method for the selective amplification and specific detection of c-kit mutation Asp816--&gt;Val in complete tissue sections cut from up to 24-year-old paraffin blocks.	Paraffin	170-178	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	84-89
12820338-0	2003	Her2/neu analysis in formalin-fixed, paraffin-embedded breast carcinomas: comparison of immunohistochemistry and multiparameter DNA flow cytometry.	Paraffin	37-45	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
12820338-8	2003	Immunohistochemistry for Her2/neu was done on paraffin sections of all cases using the same polyclonal Her2/neu antibody in a SABC-peroxidase procedure after heat-induced antigen retrieval.	Paraffin	46-54	erb-b2 receptor tyrosine kinase 2	Homo sapiens	25-33
12610357-3	2003	Aims of our study were: 1) to determine the incidence of c-Kit expression in formalin-fixed paraffin-embedded tissue (FFPE) in pulmonary small cell carcinoma (SCC) and non small cell carcinoma (NSCC), pulmonary carcinoid, and malignant mesothelioma (MM); and 2) to test the feasibility of c-Kit determination using commercially available antibodies and routine immunohistochemical settings, comparing the performance of two commercially available antibodies, Dako and Santa Cruz.	Paraffin	92-100	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	57-62
12576817-3	2003	MATERIALS AND METHODS: Immunostaining for COX-2 was performed on paraffin embedded bladder biopsy specimens from 2 independent groups of patients without muscle invasive carcinoma, including 39 with carcinoma in situ and 34 with stage T1 tumors.	Paraffin	65-73	prostaglandin-endoperoxide synthase 2	Homo sapiens	42-47
12856639-10	2003	In addition, iNOS protein levels were significantly higher in paraffin-embedded prostate cancer tissue sections than in adjacent nonneoplastic tissue.	Paraffin	62-70	nitric oxide synthase 2	Homo sapiens	13-17
12729479-7	2003	In conclusion, immunohistochemistry of CD10 in paraffin sections is valuable in the classification of thyroid follicular lesions into benign and malignant groups and in the diagnosis of follicular variant of papillary thyroid carcinoma.	Paraffin	47-55	membrane metalloendopeptidase	Homo sapiens	39-43
12559346-4	2003	METHODS: p16 and p53 expression were detected by immunohistochemical analysis of 90 paraffin specimens of resected NSCLC, including 35 squamous cell carcinoma, 47 adenocarcinoma, and eight large cell carcinoma, between stages I and IV.	Paraffin	84-92	cyclin dependent kinase inhibitor 2A	Homo sapiens	9-12
12576455-2	2003	EXPERIMENTAL DESIGN: Expression of p27(Kip1) was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded bone marrow biopsies.	Paraffin	101-109	zinc ribbon domain containing 2	Homo sapiens	35-38
12536226-0	2003	Human GLUT5 immunolabeling is useful for evaluating microglial status in neuropathological study using paraffin sections.	Paraffin	103-111	solute carrier family 2 member 5	Homo sapiens	6-11
26680909-4	2003	MATERIALS AND METHODS: The expression of c-met protein was investigated using immunohistochemical staining of 50 paraffin embedded gastric cancers, and by measuring the serum uPAR levels, before and after an operation, in gastric cancer patients using an ELISA assay.	Paraffin	113-121	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	41-46
12559346-4	2003	METHODS: p16 and p53 expression were detected by immunohistochemical analysis of 90 paraffin specimens of resected NSCLC, including 35 squamous cell carcinoma, 47 adenocarcinoma, and eight large cell carcinoma, between stages I and IV.	Paraffin	84-92	tumor protein p53	Homo sapiens	17-20
12686777-4	2003	Also, COX-2 expression was detected by an immunohistochemical method in 55 paraffin-embedded gastric adenocarcinoma tissues.	Paraffin	75-83	prostaglandin-endoperoxide synthase 2	Homo sapiens	6-11
15314975-0	2003	Expression of p21 and bcl-2 proteins in paraffin-embedded preparations of non-small cell lung cancer in stage IIIA after Etoposide and Cisplatin induced chemotherapy.	Paraffin	40-48	cyclin dependent kinase inhibitor 1A	Homo sapiens	14-17
15314975-0	2003	Expression of p21 and bcl-2 proteins in paraffin-embedded preparations of non-small cell lung cancer in stage IIIA after Etoposide and Cisplatin induced chemotherapy.	Paraffin	40-48	BCL2 apoptosis regulator	Homo sapiens	22-27
14995078-2	2003	This was a retrospective study in which MT and p53 immunopositive staining in 32 laryngeal SCC paraffin-embedded sections, were correlated with clinical recurrence.	Paraffin	95-103	tumor protein p53	Homo sapiens	47-50
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Paraffin	107-115	CD4 molecule	Homo sapiens	26-29
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Paraffin	107-115	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	36-41
12472850-2	2002	Expression of COX-2 in the TMJ disc and the synovial membrane in 26 human TMJ samples (internal derangement of TMJ; n=16, and control; n=10) was measured by an immunohistological technique using paraffin-embedded tissue and specific antihuman COX-2 polyclonal antibody.	Paraffin	195-203	prostaglandin-endoperoxide synthase 2	Homo sapiens	14-19
12474230-9	2003	Immunofluorescence studies using four formalin-fixed, paraffin wax-embedded MCL tumours demonstrated cytoplasmic localization of STAT3, as opposed to the nuclear localization of the pSTAT3 species.	Paraffin	54-66	signal transducer and activator of transcription 3	Homo sapiens	129-134
12622775-4	2003	In formalin-fixed and paraffin-embedded human tissues, immunohistochemistry revealed all known expression sites of ACE, e.g. the epithelial brush borders of proximal kidney tubules, epithelial cells of epididymis, endothelial cells, activated macrophages as well as germ cells during spermatogenesis.	Paraffin	22-30	angiotensin I converting enzyme	Homo sapiens	115-118
12566814-4	2003	Immunohistochemical analysis for p53 was done on paraffin-fixed tissues with DO-7 antibodies.	Paraffin	49-57	tumor protein p53	Homo sapiens	33-36
12456216-8	2002	Paraffin immunohistochemical studies showed positivity of the tumor cells for CD45, TIA-1, granzyme B, CD56, and CD3 epsilon.	Paraffin	0-8	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	84-89
12514788-5	2002	The expression of TGF-beta(1) mRNA in 108 paraffin-embedded cervical carcinomas was detected by mRNA in situ hybridization.	Paraffin	42-50	transforming growth factor beta 1	Homo sapiens	18-29
12429983-2	2002	Paraffin-embedded pathological tissue was utilised for the immunohistochemical analysis of mVd and TP expression.	Paraffin	0-8	mevalonate (diphospho) decarboxylase	Mus musculus	91-94
12461058-5	2002	MATERIALS/METHODS: The expression of TSP-1 was studied in formalin fixed, paraffin wax embedded sections from 58 cases of pure DCIS, using a monoclonal antibody against TSP-1 and the avidin-biotin-diaminobenzidine immunoperoxidase detection system.	Paraffin	74-86	thrombospondin 1	Homo sapiens	37-42
14752227-10	2003	RESULTS: Using paraffin-embedded gastric cancer specimens, we found AFP immunohistochemically in 2 of 25 (8%) patients.	Paraffin	15-23	alpha fetoprotein	Homo sapiens	68-71
12493030-0	2003	p53 expression in normal paraffin-embedded tissue using different antibodies and antigen retrieval buffer systems.	Paraffin	25-33	tumor protein p53	Homo sapiens	0-3
12493030-1	2003	AIMS: The study was undertaken to demonstrate wild-type p53 in normal paraffin-embedded tissues using two widely used antibodies, DO7 and 1801 and two different antigen retrieval buffer systems.	Paraffin	70-78	tumor protein p53	Homo sapiens	56-59
12493030-10	2003	CONCLUSIONS: Our study demonstrates the presence of p53 in normal paraffin-embedded tissue with nuclear and/or cytoplasmic localization in some instances.	Paraffin	66-74	tumor protein p53	Homo sapiens	52-55
12824535-1	2003	This chapter describes the techniques necessary to identify p53 genomic mutations in either frozen or paraffin-embedded tumor samples.	Paraffin	102-110	tumor protein p53	Homo sapiens	60-63
12824536-4	2003	The most important is immunocytochemical p53 staining of sections from paraffin embedded tissues.	Paraffin	71-79	tumor protein p53	Homo sapiens	41-44
12759537-2	2003	The expression of the markers examined - Bcl-2, c-erbB-2, p53 - was detected in paraffin sections of the tumors by the streptavidin-biotin peroxidase method following heat-induced antigen retrieval, and the apoptosis rate was determined by the TUNEL method.	Paraffin	80-88	BCL2 apoptosis regulator	Homo sapiens	41-46
12759537-2	2003	The expression of the markers examined - Bcl-2, c-erbB-2, p53 - was detected in paraffin sections of the tumors by the streptavidin-biotin peroxidase method following heat-induced antigen retrieval, and the apoptosis rate was determined by the TUNEL method.	Paraffin	80-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	48-56
12759537-2	2003	The expression of the markers examined - Bcl-2, c-erbB-2, p53 - was detected in paraffin sections of the tumors by the streptavidin-biotin peroxidase method following heat-induced antigen retrieval, and the apoptosis rate was determined by the TUNEL method.	Paraffin	80-88	tumor protein p53	Homo sapiens	58-61
12660452-5	2003	An immunohistochemical technique with monoclonal antibodies (DO-7) was used to detect the p53 phenotype in paraffin-fixed material.	Paraffin	107-115	tumor protein p53	Homo sapiens	90-93
12439911-4	2002	METHODS: Immunohistochemical staining of E-cadherin and beta-catenin was performed from paraffin specimens of 163 gastric carcinomas, 44 gastric mucosal dysplasia, and 25 intestinal metaplasia, 28 atrophic gastritis and 12 healthy controls.	Paraffin	88-96	cadherin 1	Homo sapiens	41-51
12459649-2	2002	In the laboratory setting, immunohistochemical staining with MIA antibody was performed in paraffin-embedded tissues from six amelanotic uveal melanomas and eight metastatic lesions of uveal melanomas.	Paraffin	91-99	MIA SH3 domain containing	Homo sapiens	61-64
12622905-10	2002	The paraffin-embedded tissues of all cases showed immunoreactivity for B-cell markers CD20, CD45RA.	Paraffin	4-12	keratin 20	Homo sapiens	86-90
12526218-11	2002	In 40 paraffin embedded specimens of BTCC, the intensity of COX-2 expression was associated with tumor grade and stage.	Paraffin	6-14	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	60-65
12658356-9	2002	CREB was detected in hepatocyte nuclei in autoclaved paraffin sections by Southwestern histochemistry.	Paraffin	53-61	cAMP responsive element binding protein 1	Mus musculus	0-4
12497652-4	2002	This study investigated the immunohistochemical expression of E-cadherin and alpha-, beta-, gamma-catenins in 33 paraffin embedded formalin fixed tissues of endometrial carcinomas.	Paraffin	113-121	cadherin 1	Homo sapiens	62-72
12439912-3	2002	The expression of Flt-1 and KDR in paraffin-embedded specimens of gastric cancer was determined by immunohistochemistry.	Paraffin	35-43	fms related receptor tyrosine kinase 1	Homo sapiens	18-23
12552965-5	2002	Immunohistochemical analysis was performed to determine BRCA1 and the apoptosis-related proteins bcl-2, Bax and p53 in paraffin-embedded tissues of 156 sporadic invasive ductal carcinomas.	Paraffin	119-127	tumor protein p53	Homo sapiens	112-115
12530058-7	2002	Stage-specific expression of the sim2-s protein was seen in normal matched paraffin sections of the colon tumors.	Paraffin	75-83	SIM bHLH transcription factor 2	Homo sapiens	33-37
12454817-2	2002	Paraffin blocks from 72 patients were selected for investigation of DNA methylation patterns in the CpG island of p16(INK4a) by methylation-specific polymerase chain reaction.	Paraffin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	114-117
12404291-4	2002	METHODS: The authors assessed the immunohistochemical expression of VEGF and metalloproteinases MMP-2 and MMP-9 in paraffin embedded biopsy specimens of malignant melanomas (18 invasive melanomas and 10 in situ melanomas); dysplastic nevi with architectural disorder and cytologic atypia of melanocytes; Spitz nevi; and compound or predominantly intradermal, ordinary, benign melanocytic nevi.	Paraffin	115-123	vascular endothelial growth factor A	Homo sapiens	68-72
12419936-7	2002	These findings suggest the accuracy of the present method of ACE genotyping from paraffin-embedded tissues.	Paraffin	81-89	angiotensin I converting enzyme	Homo sapiens	61-64
12419936-2	2002	Therefore, the present study was designed to investigate the accuracy of genotyping for the insertion (I)/deletion (D) polymorphism of the angiotensin-converting enzyme (ACE) gene from paraffin-embedded tissues of autopsy cases from Hisayama Town, Japan.	Paraffin	185-193	angiotensin I converting enzyme	Homo sapiens	170-173
12443735-1	2002	Cyclooxygenase-2 (COX-2) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 15 pigs with naturally occurring pleuropneumonia caused by Actinobacillus pleuropneumoniae.	Paraffin	87-99	prostaglandin-endoperoxide synthase 2	Sus scrofa	0-16
12443735-1	2002	Cyclooxygenase-2 (COX-2) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 15 pigs with naturally occurring pleuropneumonia caused by Actinobacillus pleuropneumoniae.	Paraffin	87-99	prostaglandin-endoperoxide synthase 2	Sus scrofa	18-23
12237881-0	2002	Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material.	Paraffin	151-159	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	68-72
12429306-3	2002	Paraffin-embedded cancer tissue samples were immunohistochemically stained for COX-2, and possible correlations with clinicopathologic features, such as age, shape and multiplicity of tumor, recurrence, and progression were examined.	Paraffin	0-8	prostaglandin-endoperoxide synthase 2	Homo sapiens	79-84
12203775-8	2002	We also examined the level of synthesis of E-cadherin protein by immunohistochemical staining in different paraffin-embedded samples of dysplastic and non-dysplastic origin in a subset of our patients.	Paraffin	107-115	cadherin 1	Homo sapiens	43-53
12209956-5	2002	Interestingly, cadherin-8, previously shown in mice to be restricted to the CNS and thymus during development, was detected by RT-PCR, immunofluorescence and in situ hybridization in 4 of 16 RCC cell lines as well as in paraffin sections of the corresponding human RCC biopsies.	Paraffin	220-228	cadherin 8	Mus musculus	15-25
12237881-0	2002	Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material.	Paraffin	151-159	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	82-87
12375051-5	2002	We, therefore, used a double differential polymerase chain reaction (ddPCR) for determination of the amplification/deletion profiles of erbB-1, -2, -3 and -4 genes in formalin-fixed, paraffin embedded (FFPE) specimens of human PHEOs.	Paraffin	183-191	epidermal growth factor receptor	Homo sapiens	136-157
12487901-3	2002	In situ hybridization (ISH) was used to demonstrate the expression of hTR in 55 cases of paraffin-embedded tarsal gland carcinoma, and the results were compared with the proliferative index determined by Mib-1 immunolabeling, histological patterns and recurrence of the tumor.	Paraffin	89-97	telomerase RNA component	Homo sapiens	70-73
12354802-5	2002	METHODS: Immunohistochemistry for MMP-13 was performed on formalin fixed, paraffin wax embedded sections of a large series of colorectal cancers (n = 249), all of which had uniform clinical and pathological information available.	Paraffin	74-86	matrix metallopeptidase 13	Homo sapiens	34-40
12237881-4	2002	This study describes an immunohistochemical method using BXP-21 to study ABCG2 expression in formalin-fixed, paraffin-embedded tissues.	Paraffin	109-117	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-78
12237881-0	2002	Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material.	Paraffin	151-159	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	73-76
12237881-0	2002	Frequent expression of the multi-drug resistance-associated protein BCRP/MXR/ABCP/ABCG2 in human tumours detected by the BXP-21 monoclonal antibody in paraffin-embedded material.	Paraffin	151-159	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	77-81
12508547-4	2002	METHODS: The expressions of MMP-9 and VEGF were detected on paraffin-embedded samples from 51 cases of OSCC, 10 cases of oral squamous cell papilloma, and 10 of normal oral mucosa by immunohistochemistry.	Paraffin	60-68	vascular endothelial growth factor A	Homo sapiens	38-42
12379773-2	2002	We used RT-PCR to examine gene expression of nitric oxide synthase 2 (NOS-2), nitric oxide synthase 3 (NOS-3), endothelin, and vascular endothelial growth factor (VEGF) and its flk-1 receptor (VEGF-R) in main pulmonary arteries and in intraparenchymal arteries microdissected from alcohol-fixed paraffin blocks.	Paraffin	295-303	vascular endothelial growth factor A	Homo sapiens	163-167
12378631-8	2002	ELISA and immunohistochemistry demonstrated that the human single chain Fv antibody against hepatitis C E2 antigen has a specific binding character with hepatitis virus E2 antigen and paraffin-embedded tissue, but did not react with liver tissues from healthy persons or patients with chronic hepatitis B.	Paraffin	184-192	CD99 molecule (Xg blood group)	Homo sapiens	104-114
12163362-7	2002	Furthermore, nested reverse transcriptase-polymerase chain reaction from formalin-fixed, paraffin-embedded tissue was performed and demonstrated that the Nkx2.5/Csx and eHAND gene product to be detected in all cases, and in three of six cases, respectively.	Paraffin	89-97	NK2 homeobox 5	Homo sapiens	154-160
12194113-5	2002	METHODS: Immunohistochemistry by a monoclonal TTF-1 antibody was performed on paraffin sections of human fetal and neonatal lung tissues.	Paraffin	78-86	NK2 homeobox 1	Homo sapiens	46-51
12243462-5	2002	The juxtamembrane domain of c-KIT was amplified using the polymerase chain reaction from genomic DNA preparations of 88 paraffin-embedded mast cell tumors from selected breeds.	Paraffin	120-128	KIT proto-oncogene, receptor tyrosine kinase	Canis lupus familiaris	28-33
12209610-3	2002	We used a MAb, 57B, recognizing MAGE-A4 protein in paraffin-embedded sections, to evaluate its expression in bladder cancers by employing TMA including 2,317 samples from 1,849 patients.	Paraffin	51-59	MAGE family member A4	Homo sapiens	32-39
12115529-5	2002	Immunoreactivity for maspin and p53 antibodies with paraffin-embedded carcinoma tissue was investigated using labeled streptavidin-biotin methods.	Paraffin	52-60	tumor protein p53	Homo sapiens	32-35
12192480-2	2002	MATERIAL AND METHODS: Immunohistochemical techniques were used to evaluate p53 expression in paraffin-embedded tissue specimens of 50 EOC cases.	Paraffin	93-101	tumor protein p53	Homo sapiens	75-78
12127055-3	2002	The analysis of HER-2 is usually performed on formalin-fixed paraffin tissue sections obtained from surgery.	Paraffin	61-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-21
12171495-2	2002	DESIGN: We performed immunohistochemistry for detection of CD10 and Bcl-6 in paraffin-embedded tissue sections from 32 patients who had surgically resected primary intestinal lymphomas.	Paraffin	77-85	membrane metalloendopeptidase	Homo sapiens	59-63
12144911-4	2002	METHODS: Retrospective screening for MEN1 gene mutations was carried out in 10 archived, paraffin-embedded neuroendocrine tumors.	Paraffin	89-97	menin 1	Homo sapiens	37-41
12147090-1	2002	AIMS: We tried to improve the evaluation of E-cadherin immunostaining in paraffin sections, to distinguish the less aggressive variants of ductal infiltrating breast cancer from other variants.	Paraffin	73-81	cadherin 1	Homo sapiens	44-54
12131365-4	2002	MATERIALS AND METHODS: We examined 48 paraffin embedded renal cell carcinoma specimens and corresponding nonneoplastic kidney tissues for the activation status of STAT3 on immunohistochemistry using anti-phospho-specific (p)-STAT3 antibody, which recognizes only activated STAT3.	Paraffin	38-46	signal transducer and activator of transcription 3	Homo sapiens	163-168
12131150-13	2002	This study emphasizes the utility of analysis of the EWS-WT1 gene fusion transcript, which was performed on paraffin-embedded tissues, to confirm the diagnosis.	Paraffin	108-116	WT1 transcription factor	Homo sapiens	53-60
12177241-3	2002	T-cadherin expression was observed in both normal epidermal basal cells and adnexal epithelial cells of formalin-fixed and paraffin-embedded tissue sections.	Paraffin	123-131	cadherin 13	Homo sapiens	0-10
12100148-5	2002	IL-6 expression was determined on paraffin-wax sections of biopsy material by means of an immunohistochemical assay.	Paraffin	34-42	interleukin 6	Homo sapiens	0-4
12062599-5	2002	The status of p53 was immunohistochemically assessed in paraffin-embedded pretreatment biopsy specimens, along with appropriate controls.	Paraffin	56-64	tumor protein p53	Homo sapiens	14-17
12119473-7	2002	RESULTS: Light microscopy of paraffin renal biopsy sections stained with a polyclonal antibody against the ASGPR showed proximal tubular epithelial cell staining of the cytoplasm and particularly in the basolateral region.	Paraffin	29-37	asialoglycoprotein receptor 1	Homo sapiens	107-112
12080224-3	2002	The expression of E-cadherin and alpha-, beta-, and gamma-catenin was investigated using immunohistochemical technique with formalin-fixed, paraffin-embedded tissue specimens obtained from 108 patients who underwent surgery for early gastric cancer.	Paraffin	140-148	cadherin 1	Homo sapiens	18-28
12167105-7	2002	Paraffin immunohistochemical analysis was carried out using anti-p53 and anti-Ki-67 antibodies on the initial tumor tissues.	Paraffin	0-8	tumor protein p53	Homo sapiens	65-68
12325482-9	2002	Fibronectin was detected in paraffin sections from 70 skin wounds of dissected subjects immunohistochemically by the indirect immunoperoxidase reaction and by the use of the ABC technique labelled with alkaline phosphatase.	Paraffin	28-36	fibronectin 1	Homo sapiens	0-11
12100961-4	2002	Specific antibodies against PDE5 were tested on both paraffin sections and cytologic smears.	Paraffin	53-61	phosphodiesterase 5A	Homo sapiens	28-32
12051635-5	2002	We evaluated calretinin reactivity in formalin-fixed, paraffin-embedded sections of 10 LCT, three SCT, five Leydig cell hyperplasia, two Sertoli cell adenomas, eight seminomatous tumors, five nonseminomatous germ cell tumors (mixed tumor), one adenomatoid tumor, and two normal testes using a standard immunohistochemical technique with a microwave-mediated epitope retrieval.	Paraffin	54-62	calbindin 2	Homo sapiens	13-23
12114287-8	2002	We found immunoreactivity for the IL-6 receptor on cultured cells and paraffin-embedded sections of adrenal tissues.	Paraffin	70-78	interleukin 6	Homo sapiens	34-38
12140380-2	2002	We investigated the expression of CD10 in formalin-fixed, paraffin-embedded tissue specimens of 72 cutaneous melanomas (28 primary, 26 metastatic to the skin and 18 lymph node metastases).	Paraffin	58-66	membrane metalloendopeptidase	Homo sapiens	34-38
12045714-5	2002	The detection of either deletion or insertion mutations within the exon 11 of KIT was performed on genomic DNA extracted from 40 paraffin-embedded samples from 38 patients.	Paraffin	129-137	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	78-81
12009234-3	2002	HER-2/neu overexpression was evaluated using immunohistochemistry (IHC) performed on paraffin-embedded specimens.	Paraffin	85-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-9
12065771-3	2002	In the present study, we investigated the heparanase mRNA expression by using in situ hybridization in 116 paraffin-embedded tissues of primary gastric carcinomas.	Paraffin	107-115	heparanase	Homo sapiens	42-52
12575349-2	2002	METHODS: MMP1 and TIMP1 proteins were detected with the immunohistochemical method of avidin-biotin complex in formalin-fixed and routinely paraffin-embeded specimens of 46 patients.	Paraffin	140-148	TIMP metallopeptidase inhibitor 1	Homo sapiens	18-23
12109783-0	2002	Expression of E-cadherin in prostate cancer in formalin-fixed, paraffin-embedded tissues: correlation with pathological features.	Paraffin	63-71	cadherin 1	Homo sapiens	14-24
12109783-2	2002	The present study aimed to assess the expression of E-cadherin in formalin-fixed and paraffin-embedded radical prostatectomy specimens and to compare its expression with the pathological stage and Gleason score.	Paraffin	85-93	cadherin 1	Homo sapiens	52-62
12168872-9	2002	The presence of bcl-2 mRNA was assessed on paraffin-embedded, 4 microm-thick sections, using a standard in situ hybridization method with a commercially available bcl-2 probe (Maxim Biotech, USA), while the streptavidin-biotin immunohistochemical technique was employed to detect bcl-2 protein expression using the monoclonal anti-bcl-2 antibody (DAKO, USA).	Paraffin	43-51	BCL2 apoptosis regulator	Homo sapiens	16-21
12229934-2	2002	For that purpose, heating for 10 min by microwave (MW) up t o 100 degrees C in citrate buffer, pH 6.0, prior to immunostaining is often used to retrieve Bcl-2 antigens in archival formalin-fixed, paraffin-embedded tissue.	Paraffin	196-204	BCL2 apoptosis regulator	Homo sapiens	153-158
12006548-3	2002	In this study, we have evaluated the expression of HER-2/neu in several fresh, established, paraffin-embedded, fixed USPCs.	Paraffin	92-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	51-60
14612291-2	2002	METHODS: The s-p immunohistochemistry assay was used to detect the expression of the bcl-2 gene on paraffin-embedded sections from 97 cases of primary pancreatic carcinoma, 32 cases of pancreatitis, and 21 cases of normal pancreas.	Paraffin	99-107	BCL2 apoptosis regulator	Homo sapiens	85-90
11914633-10	2002	Examination of the microdissected paraffin-embedded tissues revealed p53 mutations in the malignant epithelioid areas in AML but not in the renal parenchyma or typical AML areas.	Paraffin	34-42	tumor protein p53	Homo sapiens	69-72
11954027-2	2002	This immunohistochemical study evaluates the effectiveness of WT1 as a marker for malignant mesothelioma in paraffin sections of cell block preparations derived from effusion specimens.	Paraffin	108-116	WT1 transcription factor	Homo sapiens	62-65
11897797-7	2002	This study demonstrates the utility of using a recently commercially available antibody to cleaved caspase 3 in archival paraffin sections, suggesting that this may be a highly specific and sensitive method generally applicable to many studies of archival material.	Paraffin	121-129	caspase 3	Homo sapiens	99-108
11948129-3	2002	In this study, we wanted to determine: (a) whether the degree of Akt activation can be assessed by immunohistochemical staining of paraffin- embedded human prostate cancer biopsies with an antibody to phospho-Akt (Ser473); and (b) whether phospho-MAPK/Erk1/2 and phospho-Akt expression are altered in prostate cancer.	Paraffin	131-139	AKT serine/threonine kinase 1	Homo sapiens	65-68
11948129-7	2002	CONCLUSION: The activation state of the cell survival protein Akt can be analyzed in human prostate cancer by immunohistochemical staining of paraffin-embedded tissue with a phospho-specific Akt (Ser473) antibody.	Paraffin	142-150	AKT serine/threonine kinase 1	Homo sapiens	62-65
11948129-7	2002	CONCLUSION: The activation state of the cell survival protein Akt can be analyzed in human prostate cancer by immunohistochemical staining of paraffin-embedded tissue with a phospho-specific Akt (Ser473) antibody.	Paraffin	142-150	AKT serine/threonine kinase 1	Homo sapiens	191-194
11950913-0	2002	Availability of CD10 immunohistochemistry as a marker of breast myoepithelial cells on paraffin sections.	Paraffin	87-95	membrane metalloendopeptidase	Homo sapiens	16-20
11950913-3	2002	In the present study, we demonstrated CD10 immunohistochemically on paraffin sections of both normal and pathological breast tissues, comparing its staining patterns to those of smooth muscle actin (SMA), which is now commonly used to highlight myoepithelium.	Paraffin	68-76	membrane metalloendopeptidase	Homo sapiens	38-42
11950913-11	2002	We concluded that CD10 could be another useful marker of breast myoepithelial cells on paraffin sections.	Paraffin	87-95	membrane metalloendopeptidase	Homo sapiens	18-22
11950915-4	2002	In this study, we assessed the utility of paraffin section immunohistochemistry (IHC) for CD10 compared with FC in a cohort of 50 DLBCLs.	Paraffin	42-50	membrane metalloendopeptidase	Homo sapiens	90-94
11927338-3	2002	METHODS: The expression of p53, mdm2, and bcl-2 protein was studied by immunohistochemical methods in paraffin-embedded nephrectomy specimens from 112 patients whose clinicopathologic data confirmed renal cell carcinoma.	Paraffin	102-110	BCL2 apoptosis regulator	Homo sapiens	42-47
12014682-3	2002	This study was performed to examine the expression of u-PA in benign, borderline and malignant tumors of the ovary by immunohistochemical evaluation on formalin-fixed, paraffin-embedded specimens applying monoclonal antibody 3689 directed to the b-chain of u-PA.	Paraffin	168-176	plasminogen activator, urokinase	Homo sapiens	54-58
11879807-8	2002	Immunolocalization of the SOD1 and SOD2 proteins in paraffin-embedded tissue sections revealed a marked increase in the density of SOD immunopositive profiles (particularly glia) in the typical PSP brain, particularly within the white matter.	Paraffin	52-60	superoxide dismutase 1	Homo sapiens	26-30
11879807-8	2002	Immunolocalization of the SOD1 and SOD2 proteins in paraffin-embedded tissue sections revealed a marked increase in the density of SOD immunopositive profiles (particularly glia) in the typical PSP brain, particularly within the white matter.	Paraffin	52-60	superoxide dismutase 1	Homo sapiens	26-29
11927338-3	2002	METHODS: The expression of p53, mdm2, and bcl-2 protein was studied by immunohistochemical methods in paraffin-embedded nephrectomy specimens from 112 patients whose clinicopathologic data confirmed renal cell carcinoma.	Paraffin	102-110	tumor protein p53	Homo sapiens	27-30
12451999-2	2002	METHODS: Seventy-nine patients with cervical cancer and 23 with cases of normal cervical epithelium in geriatric people were investigated immunohistochemically for expression of p53 and c-erbB2 in paraffin sections.	Paraffin	197-205	tumor protein p53	Homo sapiens	178-181
12451999-2	2002	METHODS: Seventy-nine patients with cervical cancer and 23 with cases of normal cervical epithelium in geriatric people were investigated immunohistochemically for expression of p53 and c-erbB2 in paraffin sections.	Paraffin	197-205	erb-b2 receptor tyrosine kinase 2	Homo sapiens	186-193
12002339-2	2002	p53 immunohistochemical expression was determined in archival paraffin embedded tissue blocks of 30 breast sarcoma patients, (19 fibrosarcomas, nine malignant fibrohistiocytomas and two liposarcomas) treated at the Hospital do Cancer AC Camargo, Sao Paulo, Brazil from 1955 to 1990.	Paraffin	62-70	tumor protein p53	Homo sapiens	0-3
11895488-6	2002	CK7 immunostaining was performed on sections from formalin-fixed paraffin blocks.	Paraffin	65-73	keratin 7	Homo sapiens	0-3
11894632-3	2002	Immunohistochemical analysis with monoclonal antibodies against human CEA was performed in order to detect CEA in formalin fixed and paraffin embedded biopsy specimens of middle ear mucosa in chronic otitis media.	Paraffin	133-141	CEA cell adhesion molecule 3	Homo sapiens	70-73
12479060-6	2002	RESULTS: The positive rate of Smad4, p21wafI, and p16 in paraffin embedded human pancreatic cancer tissue was 58.93%, 48.21%, and 42.86%, respectively, whereas the positive rate of these proteins in matched normal tissue was 89.29%, 87.5%, and 76.79% respectively.	Paraffin	57-65	cyclin dependent kinase inhibitor 2A	Homo sapiens	50-53
12234029-4	2002	We have looked for overexpression of c-erbB-2 gene product in paraffin-embedded material from 230 cases of soft tissue sarcoma, in order to establish a possible new prognostic marker and a potentially new treatment option.	Paraffin	62-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-45
11800658-2	2002	These cytoplasmic structures were immunoreactive with antibodies against chromogranin A and synaptophysin in paraffin-embedded tissue.	Paraffin	109-117	chromogranin A	Homo sapiens	73-87
11789735-0	2002	A formalin-fixed, paraffin-processed cell line standard for quality control of immunohistochemical assay of HER-2/neu expression in breast cancer.	Paraffin	18-26	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-117
11899739-6	2002	We analyzed clinical and pathological parameters including bcl-2 expression in paraffin-embedded tumor samples using immunohistochemical technique.	Paraffin	79-87	BCL2 apoptosis regulator	Homo sapiens	59-64
11815982-6	2002	Paraffin sections of tumor were immunostained by MIC2 antibody, a marker of immature T cells.	Paraffin	0-8	CD99 molecule (Xg blood group)	Homo sapiens	49-53
11788674-9	2002	We first studied the expression of human NIS (hNIS) protein by immunohistochemistry in paraffin-embedded tissue sections using a specific anti-hNIS monoclonal antibody.	Paraffin	87-95	solute carrier family 5 member 5	Homo sapiens	41-44
12815795-5	2002	In this work we have performed the immunohistochemical method, using the monoclonal and policlonal specific antibodies against c-kit receptor (CD117) in paraffin embedded block.	Paraffin	153-161	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	143-148
12677891-8	2002	In this review we focus also on the methodology of FISH in paraffin sections and tissue imprints with respect to the detection of copy numbers of chromosome 17 and the ERBB2 gene.	Paraffin	59-67	erb-b2 receptor tyrosine kinase 2	Homo sapiens	168-173
12056646-5	2002	A series of 129 oral squamous cell cancers was investgated retrospectively for expression of P53 protein by immunohistochemistry of paraffin-embedded tissue sections.	Paraffin	132-140	tumor protein p53	Homo sapiens	93-96
12168790-6	2002	We therefore decided to establish a PCR assay for detection of GADD153 in paraffin-embedded tissue.	Paraffin	74-82	DNA damage inducible transcript 3	Homo sapiens	63-70
11788674-9	2002	We first studied the expression of human NIS (hNIS) protein by immunohistochemistry in paraffin-embedded tissue sections using a specific anti-hNIS monoclonal antibody.	Paraffin	87-95	solute carrier family 5 member 5	Homo sapiens	46-50
11825926-2	2002	METHOD: p16 expression in 225 head and neck squamous cell carcinomas (HNSCCs) was studied using an immunohistochemical method and paraffin wax embedded tumour tissues.	Paraffin	130-142	cyclin dependent kinase inhibitor 2A	Homo sapiens	8-11
12658752-2	2002	The expression of c-erbB2 was detected immunohistochemically by monoclonal antibody against the gene on the formalin-fixed paraffin sections of 21 hydatidiform moles, 21 invasive moles, 20 choriocarcinomas and 30 normal placentas.	Paraffin	123-131	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-25
11684968-0	2001	Reduced sensitivity of paraffin-based RT-PCR assays for ETV6-NTRK3 fusion transcripts in morphologically defined infantile fibrosarcoma.	Paraffin	23-31	ETS variant transcription factor 6	Homo sapiens	56-60
12680645-5	2002	Multiplex RT-nPCR could be applied successfully to formalin-fixed, paraffin-embedded tissues for the detection and differentiation between North American and European genotypes of PRRSV.	Paraffin	67-75	nasopharyngeal carcinoma-related protein	Homo sapiens	13-17
12065876-2	2002	METHODS: The expression of p53 and mdm2 was analyzed by an immunohistochemical assay in 80 formalin-fixed paraffin embedded primary tumour samples and related to the clinical response to 5-fluorouracil therapy and to the prognosis of the patients.	Paraffin	106-114	tumor protein p53	Homo sapiens	27-30
12597335-0	2002	Genetic analysis of HER-2/neu gene amplification in paraffin embedded tumour tissue in women with breast cancer.	Paraffin	52-60	erb-b2 receptor tyrosine kinase 2	Homo sapiens	20-29
12477328-4	2002	IL-8 and TNF-alpha were visualized by means of immunohistochemistry in paraffin-embedded heart valve biopsies from 6 patients with infective endocarditis who required cardiac surgery during the active phase of the infection.	Paraffin	71-79	C-X-C motif chemokine ligand 8	Homo sapiens	0-4
11504565-5	2001	In both series, ApoE was evaluated from archival paraffin-embedded brain material.	Paraffin	49-57	apolipoprotein E	Homo sapiens	16-20
11753991-4	2001	METHODS: The immunohistochemical expression of TGF-alpha, EGF-R, and c-erb B-2 was studied in paraffin material of 62 clinical Wilms tumors.	Paraffin	94-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	69-78
11843932-7	2001	Expression of VEGF and VEGF-C was evaluated by immunohistochemistry of formalin-fixed, paraffin-embedded biopsy specimens.	Paraffin	87-95	vascular endothelial growth factor A	Homo sapiens	14-18
11843932-7	2001	Expression of VEGF and VEGF-C was evaluated by immunohistochemistry of formalin-fixed, paraffin-embedded biopsy specimens.	Paraffin	87-95	vascular endothelial growth factor C	Homo sapiens	23-29
11829192-4	2001	In the present study p53 and bcl-2 expression in paraffin sections from 50 cases of laryngeal squamous cell carcinoma were analysed and correlated with routine clinico-pathological parameters.	Paraffin	49-57	BCL2 apoptosis regulator	Homo sapiens	29-34
11745466-7	2001	Mutations in the TMPRSS2 gene were screened using DNA isolated from paraffin-embedded prostate cancer tissues from 9 patients with aggressive prostate cancer and from 9 patients with nonaggressive disease.	Paraffin	68-76	transmembrane serine protease 2	Homo sapiens	17-24
11745687-1	2001	The present study analysed by immunohistochemistry the protein level of cyclin A and Ki-67 in a panel of paraffin-embedded tissue obtained from 172 primary (110 superficial and 62 nodular) and 73 metastatic melanomas, and ten benign naevi.	Paraffin	105-113	cyclin A2	Homo sapiens	72-80
11740810-4	2001	MVD was measured as mean of 10 fields (MVD) and the single highest field (SHF) on anti-CD34-stained Zenker-fixed paraffin-embedded bone marrow biopsy sections at 400x magnification.	Paraffin	113-121	CD34 molecule	Homo sapiens	87-91
12815292-7	2002	The present report based on gated analysis of androgen receptor expression in nuclei isolated from archival formalin fixed/paraffin embedded breast tumors shows that receptor expression in aneuploid sub-populations is greater than that of the diploid cells.	Paraffin	123-131	androgen receptor	Homo sapiens	46-63
11784698-1	2002	A monoclonal antibody to excitatory amino acid transporter 1 (EAAT1) has been generated which robustly stains paraffin-embedded, formaldehyde-fixed as well as snap-frozen human post-mortem brain tissue.	Paraffin	110-118	solute carrier family 1 member 3	Homo sapiens	25-60
11784698-1	2002	A monoclonal antibody to excitatory amino acid transporter 1 (EAAT1) has been generated which robustly stains paraffin-embedded, formaldehyde-fixed as well as snap-frozen human post-mortem brain tissue.	Paraffin	110-118	solute carrier family 1 member 3	Homo sapiens	62-67
11751513-3	2001	EXPERIMENTAL DESIGN: NF-kappaB activation was determined by immunohistochemical analysis of formalin-fixed, paraffin-embedded specimens from 64 gastric carcinoma patients.	Paraffin	108-116	nuclear factor kappa B subunit 1	Homo sapiens	21-30
11724658-4	2001	In 5 microm sections prepared from archival paraffin-wax blocks, VEGF-A was demonstrated by standard immunohistochemistry using a monoclonal antibody.	Paraffin	44-52	vascular endothelial growth factor A	Homo sapiens	65-71
11866987-0	2001	[Detection of the expression of Smad4, transforming growth factor beta(1) and beta receptor II proteins in paraffin-embedded human pancreatic cancer tissues].	Paraffin	107-115	transforming growth factor beta 1	Homo sapiens	39-73
11866987-2	2001	METHODS: The expression of Smad4, TGF beta1 and TbetaR II in paraffin embedded pancreatic carcinoma tissues was detected by using antibodies against Smad4, TGF beta1 and TbetaR II with EnVision immunohistochemistry.	Paraffin	61-69	transforming growth factor beta 1	Homo sapiens	34-43
11866987-2	2001	METHODS: The expression of Smad4, TGF beta1 and TbetaR II in paraffin embedded pancreatic carcinoma tissues was detected by using antibodies against Smad4, TGF beta1 and TbetaR II with EnVision immunohistochemistry.	Paraffin	61-69	transforming growth factor beta 1	Homo sapiens	156-165
11822753-7	2001	Expression of HER-2/neu was determined by immunohistochemical analysis on fixed, paraffin-embedded tissues.	Paraffin	81-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-23
11784357-2	2001	In both series, ApoE was evaluated from archival paraffin-embedded brain material.	Paraffin	49-57	apolipoprotein E	Homo sapiens	16-20
11698000-4	2001	OBJECTIVES: In this study, we investigated the expression of c-Kit in granulocytic sarcoma (GS) using paraffin-embedded tissue.	Paraffin	102-110	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	61-66
11706079-3	2001	We have developed an immunohistochemical assay that allows the evaluation of p14(ARF) expression in formalin-fixed, paraffin-embedded tissues, using commercially available antibodies.	Paraffin	116-124	cyclin dependent kinase inhibitor 2A	Homo sapiens	77-80
11679182-3	2001	Vascular endothelial growth factor (VEGF) was also immunostained on the same paraffin block specimen.	Paraffin	77-85	vascular endothelial growth factor A	Homo sapiens	0-34
11679182-3	2001	Vascular endothelial growth factor (VEGF) was also immunostained on the same paraffin block specimen.	Paraffin	77-85	vascular endothelial growth factor A	Homo sapiens	36-40
11601132-2	2001	This immunohistochemical study evaluates the effectiveness of TTF-1 as a marker for pulmonary adenocarcinomas in paraffin sections of cell block preparations derived from effusion and fine-needle aspiration specimens.	Paraffin	113-121	NK2 homeobox 1	Homo sapiens	62-67
11668470-5	2001	Immunostaining for AR on paraffin sections and imprint smears of SDC was performed, including 51 benign and other malignant salivary gland tumors.	Paraffin	25-33	androgen receptor	Homo sapiens	19-21
11813493-1	2001	Occurrence of fibronectin was detected in paraffin sections of burn skin samples, excised from surviving patients, as well as skin samples removed from the death persons, who succumbed burn wounds.	Paraffin	42-50	fibronectin 1	Homo sapiens	14-25
11740051-3	2001	Immunohistochemical staining method was used for detecting p53 and bcl-2 expression on paraffin blocks of three pure insular, five follicular or papillary thyroid carcinomas with a major insular component (more than 50%) and six with a minor insular component (20-50%).	Paraffin	87-95	tumor protein p53	Homo sapiens	59-62
11852356-7	2001	ETV6-NK3 chimeric RNA was detected by reverse transcriptase polymerase chain reaction in two cases out four cases from paraffin-embedded tissue blocks.	Paraffin	119-127	ETS variant transcription factor 6	Homo sapiens	0-4
11740051-3	2001	Immunohistochemical staining method was used for detecting p53 and bcl-2 expression on paraffin blocks of three pure insular, five follicular or papillary thyroid carcinomas with a major insular component (more than 50%) and six with a minor insular component (20-50%).	Paraffin	87-95	BCL2 apoptosis regulator	Homo sapiens	67-72
11826915-1	2001	An immunohistochemical (IHC) study of the c-erbB-2 protein was performed in paraffin-embedded tissues from 506 primary breast carcinomas.	Paraffin	76-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-50
11679947-13	2001	Thus, RT-PCR detection of EWS-CHN or TAF2N-CHN fusion gene using archival paraffin-embedded tissue is a feasible and useful ancillary technique for the diagnosis of EMCS.	Paraffin	74-82	nuclear receptor subfamily 4 group A member 3	Homo sapiens	30-33
11679947-13	2001	Thus, RT-PCR detection of EWS-CHN or TAF2N-CHN fusion gene using archival paraffin-embedded tissue is a feasible and useful ancillary technique for the diagnosis of EMCS.	Paraffin	74-82	nuclear receptor subfamily 4 group A member 3	Homo sapiens	43-46
11820718-3	2001	METHOD: Tumoral pepsinogen C expression was retrospectively analyzed in 35 paraffin-embedded tissues from patients with primary malignant cutaneous melanoma and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi and 2 dysplastic melanocytic nevi), using immunohistochemical methods.	Paraffin	75-83	progastricsin	Homo sapiens	16-28
11820720-2	2001	Immunohistochemical study of the expression of c-erbB-2 was performed in formalin-fixed, paraffin-embedded sections from 82 gastric adenocarcinomas using polyclonal antibody.	Paraffin	89-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-55
11745263-9	2001	HER2 immunohistochemistry on paraffin embedded tissue was performed in 18 patients.	Paraffin	29-37	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-4
11536377-4	2001	Hepatic encephalopathy was induced in Wistar rats by administration of CCl4 at a dose of 1 mL/kg orally in liquid paraffin (1:1) twice a week for 90 days.	Paraffin	114-122	C-C motif chemokine ligand 4	Rattus norvegicus	71-75
11555602-4	2001	We used in situ hybridization to evaluate the expression of several metastasis-related genes, including MMP-9 and E-cadherin, in paraffin-embedded biopsy specimens from 55 patients with muscle-invasive TCC treated with neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy and radical cystectomy.	Paraffin	129-137	cadherin 1	Homo sapiens	114-124
11505451-3	2001	We have developed a rat monoclonal antibody against pBHRF1, which can detect BHRF1 in paraffin sections.	Paraffin	86-94	apoptosis regulator BHRF1	Human gammaherpesvirus 4	53-58
11445851-3	2001	To characterize the involvement of the p53 gene abnormality in this disease, we analyzed expression and sequence alteration of p53 by immunohistochemical analysis of the protein expression and quantitative DNA/PCR and PCR-SSCP assays of the gene in 28 paraffin-embedded tissue specimens.	Paraffin	252-260	tumor protein p53	Homo sapiens	127-130
11758715-1	2001	The expression of EGFR family and steroid hormone receptors was examined in a series of 40 cases of pure ductal carcinoma in situ (DCIS) of the breast by immunohistochemical staining of paraffin-embedded sections.	Paraffin	186-194	epidermal growth factor receptor	Homo sapiens	18-22
11506953-3	2001	Histological analysis for E-cadherin expression was carried out on paraffin-embedded tumour tissues.	Paraffin	67-75	cadherin 1	Homo sapiens	26-36
11464277-9	2001	A polyclonal antibody generated against PHF3 shows nuclear expression in most investigated formalin-fixed, paraffin embedded tissues.	Paraffin	107-115	PHD finger protein 3	Homo sapiens	40-44
11479861-3	2001	METHODS: Immunohistochemistry staining of paraffin-embedded appendices was performed with GAP-43, VIP, and SP.	Paraffin	42-50	vasoactive intestinal peptide	Homo sapiens	98-101
11449307-2	2001	The purpose of the present study was to analyze the expression of the oncogenes c-erbB-2 and c-myc and of the suppressor gene p53 by immunohistochemical techniques in archival paraffin-embedded tissue blocks of 48 male breast cancer patients, treated at the A.C. Camargo Cancer Hospital, Sao Paulo, SP, Brazil.	Paraffin	176-184	tumor protein p53	Homo sapiens	126-129
11436168-11	2001	Ten tumors were evaluated with MIB-1, p53, and CD99 antibodies by paraffin immunohistochemistry.	Paraffin	66-74	CD99 molecule (Xg blood group)	Homo sapiens	47-51
11422747-4	2001	METHODS: P-gp expression was determined by immunohistochemistry of paraffin sections using two different monoclonal antibodies (UIC2 and MRK16).	Paraffin	67-75	ATP binding cassette subfamily B member 1	Homo sapiens	9-13
11392883-2	2001	Immunohistochemical staining for CD10 (clone 56C6) was performed on paraffin-embedded tissue from 26 cases of classic FL.	Paraffin	68-76	membrane metalloendopeptidase	Homo sapiens	33-37
11391591-5	2001	Mutations in the MEN1 gene were sought using polymerase chain reaction analysis on paraffin embedded tissue from two members of one of the families.	Paraffin	83-91	menin 1	Homo sapiens	17-21
11358811-3	2001	We identified mutations in exons 5-8 of p53 using DNA extracted from formalin-fixed paraffin-embedded tissue blocks from 146 whites and 26 non-whites with astrocytic glioma by PCR-single-strand conformation polymorphism and direct sequencing.	Paraffin	84-92	tumor protein p53	Homo sapiens	40-43
11377343-13	2001	The anti-PSMA mAbs 7E11 and PM2J004.5 are useful in the pathologic evaluation of paraffin-embedded metastatic prostate cancer specimens.	Paraffin	81-89	folate hydrolase 1	Homo sapiens	9-13
11387307-4	2001	By means of immunohistochemistry and a computerized image analysis, bcl-2 immunostaining was localized and quantified in 36 randomly selected paraffin-embedded ectopic trophoblast tissue specimens collected from women undergoing surgery for ruptured (n = 18) and non-ruptured (n = 18) tubal ectopic pregnancies.	Paraffin	142-150	BCL2 apoptosis regulator	Homo sapiens	68-73
11484979-1	2001	Paraffin embebbed tumour tissues from 47 T1-2 N0-1 M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34).	Paraffin	0-8	CD34 molecule	Homo sapiens	213-217
11316543-4	2001	METHODS AND MATERIALS: The nuclear expression of HAP1 and p53 proteins was studied by immunohistochemistry in paraffin-embedded material from 95 patients with locally advanced squamous cell head-and-neck cancer (HNC) treated with radical radiotherapy (38 cases with induction platinum-based chemotherapy and 57 with concurrent platinum chemoradiotherapy).	Paraffin	110-118	huntingtin associated protein 1	Homo sapiens	49-53
11316543-4	2001	METHODS AND MATERIALS: The nuclear expression of HAP1 and p53 proteins was studied by immunohistochemistry in paraffin-embedded material from 95 patients with locally advanced squamous cell head-and-neck cancer (HNC) treated with radical radiotherapy (38 cases with induction platinum-based chemotherapy and 57 with concurrent platinum chemoradiotherapy).	Paraffin	110-118	tumor protein p53	Homo sapiens	58-61
11378576-0	2001	Paraffin immunoreactivity of CD10, CDw75, and Bcl-6 in follicle center cell lymphoma.	Paraffin	0-8	membrane metalloendopeptidase	Homo sapiens	29-33
11378576-5	2001	Since no previous study has correlated paraffin immunoreactivity(PIR) of CD10, CDw75, and bcl-6 in FCCL (Grades 1-3), this is this study"s purpose.	Paraffin	39-47	membrane metalloendopeptidase	Homo sapiens	73-77
11378576-9	2001	Results showed that, CD10 by paraffin IH(PIH) was positive in 23 [18(strong); 3(moderate); 2(weak)] and negative in 6(3, Grade 2; 3, Grade 3).	Paraffin	29-37	membrane metalloendopeptidase	Homo sapiens	21-25
11407477-6	2001	Immunohistochemistry on paraffin-embedded tissue sections of 159 cases revealed a significant increase in intensity of ETB receptor expression from common nevi over dysplastic nevi and primary MM to metastatic MM.	Paraffin	24-32	endothelin receptor type B	Homo sapiens	119-122
11331447-5	2001	METHODS: Immunohistochemistry was used to detect VEGF expression in archival paraffin-embedded surgical thyroid specimens from 96 subjects with papillary thyroid cancer.	Paraffin	77-85	vascular endothelial growth factor A	Homo sapiens	49-53
11883122-1	2001	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Paraffin	86-94	transferrin	Homo sapiens	66-77
11306434-7	2001	Immunohistochemical studies on formalin-fixed, paraffin-embedded sections of surgical and autopsy material from lungs of individuals with LAM showed diffuse NO synthase III (NOSIII) expression in the lesional smooth muscle of LAM similar to that in the vascular endothelium.	Paraffin	47-55	nitric oxide synthase 3	Homo sapiens	157-172
11306434-7	2001	Immunohistochemical studies on formalin-fixed, paraffin-embedded sections of surgical and autopsy material from lungs of individuals with LAM showed diffuse NO synthase III (NOSIII) expression in the lesional smooth muscle of LAM similar to that in the vascular endothelium.	Paraffin	47-55	nitric oxide synthase 3	Homo sapiens	174-180
11298532-5	2001	METHODS: We examined changes in the expression of MDR-1 and MRP genes at the mRNA level before and after chemotherapy by reverse transcription-polymerase chain reaction (RT-PCR) analysis using formalin-fixed, paraffin-embedded sections of 18 specimens taken from eight melanoma patients.	Paraffin	209-217	ATP binding cassette subfamily B member 1	Homo sapiens	50-55
11298532-5	2001	METHODS: We examined changes in the expression of MDR-1 and MRP genes at the mRNA level before and after chemotherapy by reverse transcription-polymerase chain reaction (RT-PCR) analysis using formalin-fixed, paraffin-embedded sections of 18 specimens taken from eight melanoma patients.	Paraffin	209-217	ATP binding cassette subfamily C member 1	Homo sapiens	60-63
11380603-4	2001	Immunohistochemical CD34-stained paraffin-embedded bone marrow biopsies of 21 patients with stage III multiple myeloma were studied.	Paraffin	33-41	CD34 molecule	Homo sapiens	20-24
11883122-1	2001	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Paraffin	86-94	transferrin	Homo sapiens	79-81
11277419-4	2001	In their experience, nuclear or mitotic staining of Bcl-2, in contrast with cytoplasmic Bcl-2 immunoreactivity, is rarely observed in formaldehyde-fixed, paraffin-embedded breast cancer specimens.	Paraffin	154-162	BCL2 apoptosis regulator	Homo sapiens	52-57
11242790-1	2001	A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues.	Paraffin	105-113	ETS variant transcription factor 6	Homo sapiens	69-73
11242790-11	2001	These results show the diagnostic usefulness of RT-PCR methods to detect ETV6-NTRK3 fusion transcripts in archival formalin-fixed paraffin-embedded tissue and the important role of NTRK3 in the development of CIFS, despite its being a protein of little importance in differential diagnosis.	Paraffin	130-138	ETS variant transcription factor 6	Homo sapiens	73-77
11289281-4	2001	METHODS: Mutation screening of the hot spots of the K-ras gene and of the evolutionarily conserved regions of the TP53 gene was performed by denaturing gradient gel electrophoresis technique in formalin-fixed paraffin-embedded specimens of 55 consecutive patients with Dukes C colon cancer treated with adjuvant 5-fluorouracil-based chemotherapy.	Paraffin	209-217	tumor protein p53	Homo sapiens	114-118
11226731-4	2001	Paraffin sections of the fetal brains on embryonic day (ED) 10, 12, 14, 16 and 18 were applied for the immunostains of Bcl-2 and Bax.	Paraffin	0-8	B cell leukemia/lymphoma 2	Mus musculus	119-124
11277417-4	2001	The authors compared the use of different types of probes to detect calcitonin mRNA in 10 cases of formalin-fixed, paraffin-embedded medullary thyroid carcinoma with and without TSA.	Paraffin	115-123	calcitonin related polypeptide alpha	Homo sapiens	68-78
11277417-7	2001	These results show that cRNA probes are the most sensitive types of probes for detecting mRNA molecules in formalin-fixed, paraffin-embedded tissue sections and that tyramide amplification can increase the sensitivity for detection of calcitonin mRNA in formalin-fixed, paraffin-embedded tissue sections at least 2- to 4-fold with cRNA probes.	Paraffin	270-278	calcitonin related polypeptide alpha	Homo sapiens	235-245
11228231-3	2001	In a second group of five sets of twin pairs with or without TTTS, immunolocalization of Epo was performed in archived paraffin wax sections of liver and kidney collected at autopsy.	Paraffin	119-131	erythropoietin	Homo sapiens	89-92
11315621-3	2001	hBD-2 expression was studied using immunohistochemistry and in situ hybridization on formalin-fixed, paraffin-embedded tissue sections from 30 cases of squamous cell carcinoma and 6 cases of leukoplakia.	Paraffin	101-109	defensin beta 4A	Homo sapiens	0-5
12733343-4	2001	Immunohistochemical staining with monoclonal antibody against human recombinant bFGF was performed in the paraffin section of rat lung.	Paraffin	106-114	fibroblast growth factor 2	Homo sapiens	80-84
11277266-6	2001	Demethylation of the CpG loci around the Spl binding site was shown in cases with high BMP-6 expression by sequencing analysis of the methylated cytosine from paraffin-embedded materials.	Paraffin	159-167	bone morphogenetic protein 6	Homo sapiens	87-92
11426536-1	2001	We evaluated immunohistochemically the expression of two negative regulators of the cell cycle, namely retinoblastoma gene product (pRb) and WAF1/Cip1 gene product (p21), in paraffin sections from 93 patients with non-Hodgkin"s lymphomas (NHL) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival.	Paraffin	174-182	cyclin dependent kinase inhibitor 1A	Homo sapiens	141-145
11305779-3	2001	The expression and localization of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) in paraffin-embedded skin samples from that study were evaluated in the present investigation.	Paraffin	106-114	nitric oxide synthase 2	Homo sapiens	35-66
11305779-3	2001	The expression and localization of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) in paraffin-embedded skin samples from that study were evaluated in the present investigation.	Paraffin	106-114	nitric oxide synthase 2	Homo sapiens	68-72
11305779-3	2001	The expression and localization of inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX-2) in paraffin-embedded skin samples from that study were evaluated in the present investigation.	Paraffin	106-114	prostaglandin-endoperoxide synthase 2	Homo sapiens	96-101
11221862-6	2001	Annexin V staining confirmed that primary melanoma cells underwent apoptosis after treatment These experiments suggest that in situ hybridization of PAX3 on paraffin-embedded tissue may represent a novel means to identify melanoma cell lesions, which appear to become dependent on expression of this deregulated transcription factor.	Paraffin	157-165	paired box 3	Homo sapiens	149-153
11239756-3	2001	The amplification/overexpression of c-erbB-2 from fresh frozen or paraffin-embedded breast tumour tissue samples was analysed by polymerase chain reaction (PCR) technique (75%), immunohistochemically (17%) or by Southern blot analysis (8%).	Paraffin	66-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-44
11156682-3	2001	We describe a reverse transcriptase in situ PCR (RT in situ PCR) method that permits the target-specific direct incorporation of the reporter nucleotide into the different transcripts that comprise the TCR beta, using paraffin-embedded, formalin-fixed tissue.	Paraffin	218-226	T cell receptor beta locus	Homo sapiens	202-210
11156682-8	2001	We conclude that the RT in situ PCR methodology will allow the routine determination of monoclonal vs multiclonal expression patterns of the TCR beta using archival paraffin-embedded tissues.	Paraffin	165-173	T cell receptor beta locus	Homo sapiens	141-149
11175634-5	2001	OBJECTIVE: To characterize the expression pattern of E-cadherin in normal and leukemic erythroid precursors by immunohistochemistry in paraffin-embedded tissue and bone marrow aspirate smears.	Paraffin	135-143	cadherin 1	Homo sapiens	53-63
11175634-9	2001	RESULTS: In paraffin-embedded bone marrow biopsy and rib specimens and in air-dried bone marrow aspirate smears, strong membrane expression of E-cadherin was seen in the normal erythroid precursors in all cases.	Paraffin	12-20	cadherin 1	Homo sapiens	143-153
11223831-2	2001	METHODS: Expression of nm23 and MTS1 mRNA was determined by quantitative analysis from paraffin-embedded tumor tissue.	Paraffin	87-95	cyclin dependent kinase inhibitor 2A	Homo sapiens	32-36
11426536-1	2001	We evaluated immunohistochemically the expression of two negative regulators of the cell cycle, namely retinoblastoma gene product (pRb) and WAF1/Cip1 gene product (p21), in paraffin sections from 93 patients with non-Hodgkin"s lymphomas (NHL) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival.	Paraffin	174-182	cyclin dependent kinase inhibitor 1A	Homo sapiens	146-150
11426536-1	2001	We evaluated immunohistochemically the expression of two negative regulators of the cell cycle, namely retinoblastoma gene product (pRb) and WAF1/Cip1 gene product (p21), in paraffin sections from 93 patients with non-Hodgkin"s lymphomas (NHL) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival.	Paraffin	174-182	cyclin dependent kinase inhibitor 1A	Homo sapiens	165-168
12426170-2	2001	METHODS: Immunohistochemical method was used to detect the expression of CD20, CD45RO and cyclin D1 in 31 formalin- fixed and paraffin-embedded tissue samples of human small cell lymphomas.	Paraffin	126-134	keratin 20	Homo sapiens	73-77
11213078-6	2001	Active transforming growth factor (TGF) beta1 was quantified in paraffin sections by immunofluorescence and confocal microscopical analysis.	Paraffin	64-72	transforming growth factor beta 1	Homo sapiens	7-45
11208826-3	2001	MATERIALS AND METHODS: HER-2/neu overexpression was studied on paraffin sections of 85 invasive breast cancers using a panel of five monoclonal (9G6, 3B5, CB11, TAB250, GSF-HER2) and two polyclonal antibodies (A8010, A0485) in addition to the HercepTest (DAKO, Glostrup, Denmark).	Paraffin	63-71	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-32
11305953-4	2001	MATERIALS AND METHODS: We studied the expression of the genes encoding multidrug resistance associated protein (MDR1) and lung cancer associated resistance protein (LRP) in formalin-fixed, paraffin-embedded tumor samples from 52 patients treated for locally advanced breast cancer by means of induction chemotherapy followed by rescue mastectomy.	Paraffin	189-197	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
11305953-4	2001	MATERIALS AND METHODS: We studied the expression of the genes encoding multidrug resistance associated protein (MDR1) and lung cancer associated resistance protein (LRP) in formalin-fixed, paraffin-embedded tumor samples from 52 patients treated for locally advanced breast cancer by means of induction chemotherapy followed by rescue mastectomy.	Paraffin	189-197	LDL receptor related protein 1	Homo sapiens	165-168
11521731-3	2001	The method most frequently employed is immunohistochemical (IHC) detection of the HER2 receptor in paraffin sections.	Paraffin	99-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	82-86
11169510-0	2001	Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy.	Paraffin	53-61	premelanosome protein	Homo sapiens	14-19
11208730-6	2001	Single-strand conformation polymorphism analysis showed a mutation of c-kit in tumor DNA extracted from paraffin-embedded specimens.	Paraffin	104-112	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	70-75
11134189-4	2001	PATIENTS AND METHODS: Expression of mEH was semiquantitatively assessed by immunohistochemistry in sections prepared from archival paraffin blocks of primary breast cancers from 179 patients with a mean follow-up time of 81 months.	Paraffin	131-139	epoxide hydrolase 1, microsomal	Mus musculus	36-39
11124460-1	2001	Localization of calmodulin, a calcium binding protein, was identified in adult gerbil cochleas using paraffin section immunohistochemistry and immunogold electron microscopy with monoclonal antibody against bovine calmodulin.	Paraffin	101-109	calmodulin	Bos taurus	16-26
21340809-0	2001	c-erbB-2 Immunohistochemistry in Paraffin Tumors.	Paraffin	33-41	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
11223819-1	2001	BACKGROUND: Immunohistological methods for the detection of estrogen receptor in human breast cancer using formalin-fixed, paraffin-embedded tissue not only have the advantages of being cheaper and requiring less tissue but also have several theoretical advantages.	Paraffin	123-131	estrogen receptor 1	Homo sapiens	60-77
11692147-2	2001	Immunohistochemical analysis of MDM2 and p53 proteins on paraffin embedded sections from 64 surgically resected ESCCs and matched histologically normal tissues showed overexpression of MDM2 protein in 23/64 (36%) ESCCs, while the histopathologically normal esophageal tissues did not show detectable level of MDM2 immunoreactivity.	Paraffin	57-65	tumor protein p53	Homo sapiens	41-44
21340896-4	2001	The advantages of SPF as a proliferative index include that it can be obtained rapidly from fresh, frozen, or paraffin wax-embedded tissue without the need for radioactive chemicals.	Paraffin	110-122	SEC14 like lipid binding 2	Homo sapiens	18-21
21340899-3	2001	The ICRF In Situ Hybridization Service has hybridized more than 44,000 sections of principally formalin-fixed, paraffin wax-embedded tissues, with a high success rate.	Paraffin	111-123	regenerating family member 1 alpha	Homo sapiens	4-8
11148457-1	2001	Expression of p53 protein and MDM2 was evaluated in paraffin-embedded tissue from 78 patients with papillary carcinomas of the thyroid (PCT), in order to elucidate the relationship between them and their correlations with some clinicopathologic features implicated in tumor progression.	Paraffin	52-60	tumor protein p53	Homo sapiens	14-17
11326673-4	2000	MATERIALS AND METHODS: In primary breast carcinoma samples from 115 women undergoing surgery in our department in 1999, a polyclonal rabbit antibody to human c-erbB-2 oncoprotein was used for immunohistochemical assessment of the c-erbB-2 expression in formalin-fixed paraffin-embedded material.	Paraffin	268-276	erb-b2 receptor tyrosine kinase 2	Homo sapiens	158-166
11127916-0	2000	Immunohistochemical detection of CD10 in paraffin sections of hematopoietic neoplasms: a comparison with flow cytometry detection in 56 cases.	Paraffin	41-49	membrane metalloendopeptidase	Homo sapiens	33-37
11127916-4	2000	Thirty-nine of the 40 (97%) flow cytometric CD10-positive cases also expressed CD10 by immunohistochemistry in formalin- or B5-fixed, paraffin-embedded tissue, with only one case of precursor B-lymphoblastic leukemia being positive by flow cytometry and negative by immunohistochemistry.	Paraffin	134-142	membrane metalloendopeptidase	Homo sapiens	44-48
11127916-4	2000	Thirty-nine of the 40 (97%) flow cytometric CD10-positive cases also expressed CD10 by immunohistochemistry in formalin- or B5-fixed, paraffin-embedded tissue, with only one case of precursor B-lymphoblastic leukemia being positive by flow cytometry and negative by immunohistochemistry.	Paraffin	134-142	membrane metalloendopeptidase	Homo sapiens	79-83
11127916-8	2000	This study demonstrates that the new CD10 monoclonal antibody clone 56C6 is a reliable marker for detection of CD10 antigen expression in formalin-and B5-fixed paraffin-embedded tissue after heat-induced epitope retrieval when compared with flow cytometry detection of fresh tissue samples.	Paraffin	160-168	membrane metalloendopeptidase	Homo sapiens	37-41
11127916-8	2000	This study demonstrates that the new CD10 monoclonal antibody clone 56C6 is a reliable marker for detection of CD10 antigen expression in formalin-and B5-fixed paraffin-embedded tissue after heat-induced epitope retrieval when compared with flow cytometry detection of fresh tissue samples.	Paraffin	160-168	membrane metalloendopeptidase	Homo sapiens	111-115
11127917-0	2000	CD10 expression in follicular lymphoma versus reactive follicular hyperplasia: evaluation in paraffin-embedded tissue.	Paraffin	93-101	membrane metalloendopeptidase	Homo sapiens	0-4
11127917-12	2000	These findings indicate that immunohistochemical staining of paraffin-embedded tissue sections for CD10 may help differentiate reactive from neoplastic follicular lesions.	Paraffin	61-69	membrane metalloendopeptidase	Homo sapiens	99-103
11127920-3	2000	We retrospectively investigated the immunohistochemical expression of p21 protein in consecutive paraffin sections from 131 transitional cell carcinomas (TCCs) and related it to p53 protein expression, clinicopathologic parameters, proliferative fraction, and survival.	Paraffin	97-105	cyclin dependent kinase inhibitor 1A	Homo sapiens	70-73
11062142-2	2000	This study analyzed the correlation of hnRNP A2/B1 expression with molecular alterations in phenotypically different epithelial cells of paraffin-embedded pulmonary tissues.	Paraffin	137-145	heterogeneous nuclear ribonucleoprotein A2/B1	Homo sapiens	39-47
12107344-4	2001	METHOD: A polyclonal antibody against caspase-3 was applied using a standard immunohistochemical procedure to paraffin sections.	Paraffin	110-118	caspase 3	Homo sapiens	38-47
11194191-4	2000	Paraffin embedded skin tissues were stained with monoclonal antibodies to human ER and PR by immunohistochemistry.	Paraffin	0-8	estrogen receptor 1	Homo sapiens	80-82
11102891-4	2000	Immunoreactivity for EGF-R, TGF-alpha, p53 and c-erbB-2 with paraffin-embedded carcinoma tissue was investigated using labeled streptavidin-biotin methods.	Paraffin	61-69	epidermal growth factor receptor	Homo sapiens	21-26
11102891-4	2000	Immunoreactivity for EGF-R, TGF-alpha, p53 and c-erbB-2 with paraffin-embedded carcinoma tissue was investigated using labeled streptavidin-biotin methods.	Paraffin	61-69	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-55
11073807-10	2000	We conclude that CISH, using conventional bright-field microscopy in evaluation, is a useful alternative for determination of HER-2/neu amplification in paraffin-embedded tumor samples, especially for confirming the immunohistochemical staining results.	Paraffin	153-161	erb-b2 receptor tyrosine kinase 2	Homo sapiens	132-135
11051374-4	2000	Mutation detection of the KRAS and TP53 genes was performed on paraffin-embedded tumor material, using denaturating gradient gel electrophoresis.	Paraffin	63-71	tumor protein p53	Homo sapiens	35-39
11137210-5	2000	4H84 and HCA2 bind to HLA-G despite aldehyde fixation and also paraffin embedding.	Paraffin	63-71	hydroxycarboxylic acid receptor 2	Homo sapiens	9-13
11054722-2	2000	The expression of ACE was studied by immunohistochemistry in paraffin-embedded lung sections from adults undergoing heart-lung transplantation for severe primary (n=6) and secondary (n=7) pulmonary arterial hypertension (PH), compared with age-matched controls (n=11).	Paraffin	61-69	angiotensin I converting enzyme	Homo sapiens	18-21
11106083-4	2000	In addition, the identification of this case supports the suggestion that the use of CD20 antibodies alone in paraffin sections may lead to an incorrect determination of cell lineage in some cases.	Paraffin	110-118	keratin 20	Homo sapiens	85-89
11070118-4	2000	Topo-IIalpha and c-erbB-2 immunoreactivity were detected on paraffin sections.	Paraffin	60-68	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-25
11012744-10	2000	Neoplastic cells in paraffin-embedded tissue specimens from these patients had CD3(CD3epsilon)+ CD56(123C3)+ granzyme+ TIA-1+ EBERT+ CD43(MT1)- CD45RO(UCHL-1)- CD57(Leu7)- CD20(L26)- phenotypes.	Paraffin	20-28	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	119-124
11012744-10	2000	Neoplastic cells in paraffin-embedded tissue specimens from these patients had CD3(CD3epsilon)+ CD56(123C3)+ granzyme+ TIA-1+ EBERT+ CD43(MT1)- CD45RO(UCHL-1)- CD57(Leu7)- CD20(L26)- phenotypes.	Paraffin	20-28	sialophorin	Homo sapiens	133-137
11064816-2	2000	STUDY DESIGN: The immunohistochemical (IHC) expression of VEGF and FGFR was examined in paraffin sections of 56 NSCLC in relation to the presence of lymph node metastases and p53 expression.	Paraffin	88-96	vascular endothelial growth factor A	Homo sapiens	58-62
11064817-2	2000	STUDY DESIGN: In this immunohistochemical study we investigated staining patterns and then determined the correlation between TGF-beta 1 expression and androgen receptor status in the epithelium and stroma of 60 paraffin-embedded tissues from radical prostatectomies.	Paraffin	212-220	androgen receptor	Homo sapiens	152-169
11100749-4	2000	Immunohistochemical CD34 stained paraffin-embedded bone marrow biopsies of 44 patients with newly diagnosed MM were studied.	Paraffin	33-41	CD34 molecule	Homo sapiens	20-24
11202158-0	2000	Pitfalls in the immunohistochemical localization of the cystic fibrosis transmembrane conductance regulator in paraffin embedded sweat glands.	Paraffin	111-119	CF transmembrane conductance regulator	Homo sapiens	56-107
11202158-4	2000	The purpose of this study was to test CFTR antibodies in paraffin-embedded skin biopsies to take advantage of the superior tissue preservation as compared to cryofixation.	Paraffin	57-65	CF transmembrane conductance regulator	Homo sapiens	38-42
11070123-2	2000	hTR expression was determined by in situ hybridization (ISH) on paraffin-embedded sections, obtained from patients with cervical intraepithelial neoplasia (CIN) I-III or cervical cancer and from normal controls.	Paraffin	64-72	telomerase RNA component	Homo sapiens	0-3
11032854-2	2000	In hematoxylin and eosin-stained paraffin sections, we detect empty lacunae in osteocytes in calvariae from Col1a1(r/r) mice at age 2 weeks, increasing through age 10-12 months.	Paraffin	33-41	collagen, type I, alpha 1	Mus musculus	108-114
11344609-1	2000	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Paraffin	86-94	transferrin	Homo sapiens	66-77
11344609-1	2000	The present study was planned to detect the iron binding protein, transferrin (TR) in paraffin sections of the human breast tumors.	Paraffin	86-94	transferrin	Homo sapiens	79-81
11268475-3	2000	PATIENTS AND METHODS: Nuclear immunohistochemical expression of p53 protein was determined in formalin-fixed paraffin-embedded archival tumor tissue samples from 190 primary colorectal adenocarcinomas.	Paraffin	109-117	tumor protein p53	Homo sapiens	64-67
11062698-5	2000	The aim of this study was to detect the protein expression patterns of MDR-1 product by immunohistochemistry in formalin-fixed-paraffin-embedded tissues.	Paraffin	127-135	ATP binding cassette subfamily B member 1	Homo sapiens	71-76
11107054-5	2000	In the three cases, a reverse transcription-polymerase chain reaction (RT-PCR) using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX1 fusion gene transcripts resulting from translocation t(X;18)(p11.2;q11.2), which is specific for synovial sarcoma.	Paraffin	133-141	SSX family member 1	Homo sapiens	172-176
11131659-3	2000	METHODS: We investigated the immunohistochemical expression of the CD10 antigen on formalin-fixed, paraffin-embedded tissue specimens of normal skin and 162 cutaneous proliferative lesions, mostly mesenchymal tumors.	Paraffin	99-107	membrane metalloendopeptidase	Homo sapiens	67-71
10948336-3	2000	To characterize the involvement of the p53 gene abnormality in this disease, we analyzed expression and sequence alteration of p53 by immunohistochemical analysis of the protein expression and quantitative DNA/PCR and PCR-SSCP assays of the gene in 33 paraffin-embedded tissue specimens.	Paraffin	252-260	tumor protein p53	Homo sapiens	127-130
11014570-0	2000	Anti-CD10 immunoperoxidase staining of paraffin-embedded acute leukemias: comparison with flow cytometric immunophenotyping.	Paraffin	39-47	membrane metalloendopeptidase	Homo sapiens	5-9
11014570-3	2000	56C6 is a monoclonal antibody that is now commercially available for the detection of CD10 in routinely processed paraffin-embedded tissue.	Paraffin	114-122	membrane metalloendopeptidase	Homo sapiens	86-90
11014570-12	2000	We conclude that immunohistochemical staining of paraffin-embedded tissue, either B5- or formalin-fixed, is an effective method for the detection of CD10 in acute leukemia.	Paraffin	49-57	membrane metalloendopeptidase	Homo sapiens	149-153
10953132-2	2000	MATERIALS AND METHODS: Immunohistochemical staining for p53 was semiquantitatively scored in archival formalin fixed, paraffin embedded tumor tissue obtained at diagnosis in 221 patients with prostate cancer.	Paraffin	118-126	tumor protein p53	Homo sapiens	56-59
10944602-3	2000	Pre-treatment tumour VEGF expression was examined immunohistochemically in formalin-fixed, paraffin-embedded biopsies using a widely available commercial antibody.	Paraffin	91-99	vascular endothelial growth factor A	Homo sapiens	21-25
10948341-5	2000	Immunostaining for p53 protein with 4 different antibodies was performed on paraffin-embedded specimens from 69 patients with adenocarcinoma and squamous cell carcinoma of the oesophagus.	Paraffin	76-84	tumor protein p53	Homo sapiens	19-22
11071572-6	2000	Reverse transcriptase-polymerase chain reaction performed on paraffin block-retrieved tissue demonstrated the EWS/WT-1 fusion transcript characteristic of the t(11;22)(p13;q12).	Paraffin	61-69	WT1 transcription factor	Homo sapiens	110-118
20950544-26	2000	TSP-1 can be detected reliably in formalin-fixed , paraffin-embedded tissues by immunohistochemical method.	Paraffin	51-59	thrombospondin 1	Homo sapiens	0-5
10861481-5	2000	In addition, we analyzed the p16-protein expression of 28 primary gastric carcinomas and their normal counterparts by immunohistochemical staining (IHC) on paraffin sections.	Paraffin	156-164	cyclin dependent kinase inhibitor 2A	Homo sapiens	29-32
10912946-1	2000	Desmoplastic small round-cell tumor of the paratesticular region: report of an adult case with demonstration of EWS and WT1 gene fusion using paraffin-embedded tissue.	Paraffin	142-150	WT1 transcription factor	Homo sapiens	120-123
11775943-3	2000	bcl-2 expression in these paraffin embraced specimens was examined by immunohistochemical technique with specific monoclonal antibodies.	Paraffin	26-34	BCL2 apoptosis regulator	Homo sapiens	0-5
10888749-1	2000	Recent studies on paraffin-embedded tissue have shown that the cyclin-dependent kinase inhibitor p27(Kip1) is expressed in normal thyroid cells, whereas it is downregulated in neoplastic cells.	Paraffin	18-26	zinc ribbon domain containing 2	Homo sapiens	97-100
10878544-5	2000	IL-6 receptor immunostaining was evaluated in 21 paraffin-embedded prostate tumour specimens.	Paraffin	49-57	interleukin 6	Homo sapiens	0-4
10870048-5	2000	The zygosity status of alpha-1-antitrypsin was verified by analysis of single strand conformational polymorphism and by sequencing DNA extracted from paraffin embedded tissue.	Paraffin	150-158	serpin family A member 1	Homo sapiens	23-42
10811105-5	2000	c-kit mutations were analyzed on paraffin-embedded specimens by PCR-single-strand conformation polymorphism followed by direct sequencing; the c-kit proto-oncogene encodes a receptor of tyrosine kinase, which plays an important role in the regulation of normal and neoplastic hematopoiesis by the interaction with its specific ligand, termed stem cell factor.	Paraffin	33-41	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	0-5
10854209-5	2000	As a model system amplification of c-erbB2/Her-2/neu gene and the adjacent topoisomerase IIalpha gene was determined in paraffin-embedded breast cancer specimens (n = 23) after immunohistochemical labeling and laser-based microdissection of tumor cells.	Paraffin	120-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-42
10854209-5	2000	As a model system amplification of c-erbB2/Her-2/neu gene and the adjacent topoisomerase IIalpha gene was determined in paraffin-embedded breast cancer specimens (n = 23) after immunohistochemical labeling and laser-based microdissection of tumor cells.	Paraffin	120-128	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-52
10937066-0	2000	Protein kinase C (PKC) isoenzymes immunohistochemistry in lymph node revealing solution-fixed, paraffin-embedded bladder tumors.	Paraffin	95-103	protein kinase C alpha	Homo sapiens	18-21
10850547-2	2000	A novel polymerase chain reaction (PCR) approach for the analysis of the entire p53 coding and splice site regions from microdissected, formalin-fixed, paraffin-embedded tumor tissues has been developed which allows multiple genetic analyses to be performed from one primary amplification reaction.	Paraffin	152-160	tumor protein p53	Homo sapiens	80-83
10897337-3	2000	This is a highly selective approach, whereby immunostained sections of formalin fixed, paraffin wax embedded tissue are exposed to ultraviolet irradiation to damage the DNA in p53 negative cells.	Paraffin	87-99	tumor protein p53	Homo sapiens	176-179
10782151-4	2000	A new antibody for CD10 (56C6) in paraffin embedded tissue sections, however, has recently become available.	Paraffin	34-42	membrane metalloendopeptidase	Homo sapiens	19-23
10782151-5	2000	OBJECTIVE: To study the expression of CD10 in paraffin sections of T-lymphoblastic lymphoma/leukemia using monoclonal antibody 56C6.	Paraffin	46-54	membrane metalloendopeptidase	Homo sapiens	38-42
10874882-6	2000	Our findings suggest that with the use of the paraffin-reactive antibodies CD34 (QBEND10), MPO, CD68 (PG-M1), antihemoglobin, and factor VIII-related antigen, immunohistochemistry can be used to subclassify AML.	Paraffin	46-54	CD34 molecule	Homo sapiens	75-79
10843285-3	2000	WT1 immunostaining was performed on paraffin material using the WT(C-19) antibody after heat-antigen retrieval.	Paraffin	36-44	WT1 transcription factor	Homo sapiens	0-3
10843287-0	2000	CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas.	Paraffin	29-37	membrane metalloendopeptidase	Homo sapiens	0-4
10874665-6	2000	Mdm2 and p53 were demonstrated by immunohistology on formalin-fixed and paraffin-embedded tumor tissue.	Paraffin	72-80	tumor protein p53	Homo sapiens	9-12
11127510-0	2000	Mutation analysis of the p53 tumor suppressor gene using paraffin-embedded specimens of human transitional cell carcinomas by the direct sequencing method.	Paraffin	57-65	tumor protein p53	Homo sapiens	25-28
10785471-3	2000	METHODS: The expression of p21 was evaluated by immunohistochemical analysis with the monoclonal antibody WAF1 (Oncogene Science) on 106 formalin-fixed, paraffin-embedded tissue samples of epithelial ovarian cancer.	Paraffin	153-161	cyclin dependent kinase inhibitor 1A	Homo sapiens	27-30
10815906-4	2000	The overexpression of mdm2 and p53 proteins was investigated on paraffin-embedded material by using monoclonal antibodies.	Paraffin	64-72	tumor protein p53	Homo sapiens	31-34
10885605-5	2000	p53 staining was performed by immunohistochemistry, using the monoclonal antibody DO7 on paraffin-embedded tissue.	Paraffin	89-97	tumor protein p53	Homo sapiens	0-3
10748449-4	2000	Immunohistochemical localization of PRL was performed on formalin-fixed paraffin-embedded tissue sections.	Paraffin	72-80	prolactin	Homo sapiens	36-39
10759187-3	2000	The in situ hybridization procedure on formalin-fixed paraffin-embedded material was improved to such a degree that we could, for the first time, visualize AVP mRNA expressing neurons in the human SCN and carry out quantitative measurements.	Paraffin	54-62	arginine vasopressin	Homo sapiens	156-159
10809364-4	2000	28 gastric dysplasia, 45 Early GC and 98 Advanced Gastric Cancers were evaluated for expression of the oncogenes p53, c-ErbB2, c-myc and the EGFr in paraffin-embedded material utilizing Avidin-Biotin immunohistochemistry techniques.	Paraffin	149-157	tumor protein p53	Homo sapiens	113-116
10809367-6	2000	By immunohistochemistry done with a polyclonal antibody to recombinant FGF-2 on paraffin sections, FGF-2 was localized in fibroblasts, endothelial cells and smooth muscle cells of tissue samples of BPH.	Paraffin	80-88	fibroblast growth factor 2	Homo sapiens	71-76
10809367-6	2000	By immunohistochemistry done with a polyclonal antibody to recombinant FGF-2 on paraffin sections, FGF-2 was localized in fibroblasts, endothelial cells and smooth muscle cells of tissue samples of BPH.	Paraffin	80-88	fibroblast growth factor 2	Homo sapiens	99-104
11775905-3	2000	Immunohistochemical staining of 27 paraffin sections was performed using antibodies to ER and PR.	Paraffin	35-43	estrogen receptor 1	Homo sapiens	87-89
10786806-4	2000	We used R-PCR to analyze estrogen receptor gene expression in a series of invasive breast carcinomas, and our results show an excellent correlation between estrogen receptor mRNA expression and protein product accumulation determined by standard immunocytochemistry on paraffin sections.	Paraffin	269-277	estrogen receptor 1	Homo sapiens	156-173
10780666-3	2000	Expression and mutations of the p53 gene were examined in the paraffin-embedded specimens of the nasal lesions from 42 Chinese (Beijing and Chengdu) and Japanese (Okinawa and Osaka) patients with nasal NK/T-cell lymphoma by the immunohistochemistry and single strand conformation polymorphism (SSCP) analysis of polymerase chain reaction (PCR) amplified products followed by direct sequencing.	Paraffin	62-70	tumor protein p53	Homo sapiens	32-35
10718209-7	2000	In the present study the authors optimized a polymerase chain reaction-based mutation screening method, fluorescence-single strand conformation polymorphism (F-SSCP), that allows p53 status to be assessed accurately and reproducibly in routinely handled, formalin-fixed and paraffin-embedded tumor specimens.	Paraffin	274-282	tumor protein p53	Homo sapiens	179-182
10751531-3	2000	Silver staining PCR-SSCP method was used to detect mutations in exons 5, 6, 7, 8 of p53 gene and MSI at 4 loci on chromosomes 2, 5, 17 in the 73 paraffin-embedded biopsy specimens, and the relationship between them was studied further.	Paraffin	145-153	tumor protein p53	Homo sapiens	84-87
10705818-0	2000	Paraffin-section detection of CD10 in 505 nonhematopoietic neoplasms.	Paraffin	0-8	membrane metalloendopeptidase	Homo sapiens	30-34
10705818-6	2000	The monoclonal antibody clone 56C6 is a reliable marker for CD10 in paraffin immunohistochemistry after heat-induced epitope retrieval.	Paraffin	68-76	membrane metalloendopeptidase	Homo sapiens	60-64
10704736-3	2000	To elucidate the possible role of P-gp in such an intrinsic drug resistance of prostate cancers, its expression was examined immunohisochemically using two P-gp isoform-specific monoclonal antibodies (mAbs) with the paraffin embedded prostate samples derived from five nonmalignant and 30 untreated prostate cancer patients.	Paraffin	216-224	ATP binding cassette subfamily B member 1	Homo sapiens	34-38
20937211-2	2000	METHODS: Immunohistochemistry was employed to detect the expression of p16 protein in 114 paraffin-embedded primary lung cancer tissues.	Paraffin	90-98	cyclin dependent kinase inhibitor 2A	Homo sapiens	71-74
10927863-3	2000	Paraffin sections were stained by using monoclonal antibody D07 for p53 protein and PC-10 for PCNA.	Paraffin	0-8	tumor protein p53	Homo sapiens	68-71
10735609-0	2000	Detection of alpha-1-antitrypsin PiZ individuals by SSCP and DNA sequencing in formalin-fixed and paraffin-embedded tissue: a comparison with immunohistochemical analysis.	Paraffin	98-106	serpin family A member 1	Homo sapiens	13-32
10735609-8	2000	DNA sequence analysis revealed the same single-base mutation at position 342 of AAT exon V. CONCLUSIONS: SSCP analysis proved a sensitive and specific technique for the detection of the PiZ mutation at the gene level, which allowed unequivocal differentiation between heterozygous and homozygous PiZ status from paraffin-embedded archival tissue specimens.	Paraffin	312-320	serpin family A member 1	Homo sapiens	80-83
10735946-4	2000	We studied the expression of iNOS in paraffin sections of 41 benign naevi and 52 primary malignant melanomas (MM) of the skin, as well as in 13 metastatic MM.	Paraffin	37-45	nitric oxide synthase 2	Homo sapiens	29-33
10682666-3	2000	Immunohistochemical p53 (pAb 1801 mAb) and TS (TS106 mAb) expression on formalin-fixed paraffin-embedded primary tumour specimens was related to probability of clinical response to chemotherapy, time to progression and overall survival.	Paraffin	87-95	tumor protein p53	Homo sapiens	20-23
10664627-4	2000	We compared the results from 2 laboratories for HER-2/neu determined by IHC on paraffin sections of the same 100 consecutive invasive breast cancers.	Paraffin	79-87	erb-b2 receptor tyrosine kinase 2	Homo sapiens	48-57
10644313-4	2000	Immunohistochemical detection of p53 and c-erbB-2 expression was performed on paraffin wax embedded tissue.	Paraffin	78-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	41-49
10741470-5	2000	CCK-BR mRNA was detected in paraffin tissue sections by the highly sensitive method of in situ reverse transcriptase-polymerase chain reaction (RT-PCR).	Paraffin	28-36	cholecystokinin B receptor	Homo sapiens	0-6
10640975-16	2000	Compared with 7E11, the PM2J004.5 anti-PSMA mAb is a more sensitive immunohistochemical marker of prostate carcinoma in formalin fixed, paraffin embedded tissue.	Paraffin	136-144	folate hydrolase 1	Homo sapiens	39-43
10646863-9	2000	Immunohistochemistry experiments showed that topoisomerase IIalpha and ICBP90 were coexpressed in proliferating areas of paraffin-embedded human appendix tissues and in high-grade breast carcinoma tissues.	Paraffin	121-129	UHRF1 binding protein 1	Homo sapiens	71-77
10632491-0	2000	Utility of paraffin section immunohistochemistry for C-KIT (CD117) in the differential diagnosis of systemic mast cell disease involving the bone marrow.	Paraffin	11-19	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	53-58
10632491-0	2000	Utility of paraffin section immunohistochemistry for C-KIT (CD117) in the differential diagnosis of systemic mast cell disease involving the bone marrow.	Paraffin	11-19	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	60-65
10632491-5	2000	The authors have employed immunohistochemistry for the C-KIT encoded tyrosine kinase receptor protein, CD117, for detection of mast cells on paraffin sections of 89 bone marrow specimens including systemic mast cell disease and other disorders.	Paraffin	141-149	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	55-60
10632491-5	2000	The authors have employed immunohistochemistry for the C-KIT encoded tyrosine kinase receptor protein, CD117, for detection of mast cells on paraffin sections of 89 bone marrow specimens including systemic mast cell disease and other disorders.	Paraffin	141-149	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	103-108
10618603-4	2000	Immunohistochemical expression of nuclear p53 protein was assessed in formalin fixed, paraffin embedded archival tumor tissue.	Paraffin	86-94	tumor protein p53	Homo sapiens	42-45
11827067-9	2000	Western blotting of the proteins isolated from the tumor tissues and immunohistochemical control study on the paraffin samples of a third of these cases (25/86) all indicated a significant upregulation of the c-met protein in the Dukes" C tumor glands compared to the Dukes" B stages (P &lt; 0.001 and P &lt; 0.05, respectively).	Paraffin	110-118	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	209-214
10667465-4	2000	About 20% of paraffin-embedded tissues from the breast cancers of cases were identified as positive for HER-2/neu amplification (HER-2/neu+) by differential PCR.	Paraffin	13-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	104-113
10667465-4	2000	About 20% of paraffin-embedded tissues from the breast cancers of cases were identified as positive for HER-2/neu amplification (HER-2/neu+) by differential PCR.	Paraffin	13-21	erb-b2 receptor tyrosine kinase 2	Homo sapiens	129-139
10855503-5	2000	In order to shed some light on this issue, we analysed the localisation of two proteins that are involved in early steps of meiotic recombination, RAD50 and MRE11, relative to AEs and SCs by immunofluorescence labelling of paraffin sections of the mouse testis, using affinity-purified polyclonal antibodies against RAD50 and MRE11, and monoclonal and polyclonal antibodies against SC components.	Paraffin	223-231	RAD50 double strand break repair protein	Mus musculus	147-152
11831985-2	2000	METHODS: Immunohistochemical SABC method was used to detect the expression of proto-oncogene bcl-2 and MTS1/p16 in 51 paraffin-embedded primary transitional cell carcinoma of bladder specimens and 5 normal bladder mucosa specimens.	Paraffin	118-126	BCL2 apoptosis regulator	Homo sapiens	93-98
10664070-5	2000	In paraffin sections, positive immunolabeling for catalase was distributed along the apical cytoplasm of the epithelia of digestive ducts and stomach and throughout the cytoplasm of digestive tubule cells.	Paraffin	3-11	catalase	Homo sapiens	50-58
11050805-0	2000	Bcl-2 molecular analysis in paraffin-embedded biopsies from diffuse large B-cell lymphomas.	Paraffin	28-36	BCL2 apoptosis regulator	Homo sapiens	0-5
10658907-0	2000	Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors.	Paraffin	111-119	ETS variant transcription factor 6	Homo sapiens	17-21
10658907-1	2000	We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks.	Paraffin	261-269	ETS variant transcription factor 6	Homo sapiens	111-115
10636514-5	2000	Immunohistochemical staining was performed to assess p53 expression in paraffin-embedded ovarian cancers.	Paraffin	71-79	tumor protein p53	Homo sapiens	53-56
10974929-4	2000	p53 protein accumulation was detected by immunohistochemistry using antibodies against p53: NCL-p53 (clone BP-53-12) (Novocastra) on paraffin embedded specimens.	Paraffin	133-141	tumor protein p53	Homo sapiens	0-3
11831985-2	2000	METHODS: Immunohistochemical SABC method was used to detect the expression of proto-oncogene bcl-2 and MTS1/p16 in 51 paraffin-embedded primary transitional cell carcinoma of bladder specimens and 5 normal bladder mucosa specimens.	Paraffin	118-126	cyclin dependent kinase inhibitor 2A	Homo sapiens	103-107
11831985-2	2000	METHODS: Immunohistochemical SABC method was used to detect the expression of proto-oncogene bcl-2 and MTS1/p16 in 51 paraffin-embedded primary transitional cell carcinoma of bladder specimens and 5 normal bladder mucosa specimens.	Paraffin	118-126	cyclin dependent kinase inhibitor 2A	Homo sapiens	108-111
10606817-6	1999	Sequence analysis of exons 5 through 8 of p53 was performed on cloned PCR-amplified DNA of formalin-fixed, paraffin-embedded tumors.	Paraffin	107-115	tumor protein p53	Homo sapiens	42-45
10697578-6	1999	The expression of primary tumor bcl-2 protein was immunohistochemically evaluated by antihuman bcl-2 monoclonal antibody (diluted 1:100, Dako, Copenhagen, Denmark) on formalin-fixed paraffin-embedded tissue.	Paraffin	182-190	BCL2 apoptosis regulator	Homo sapiens	32-37
10632350-1	1999	To evaluate both the clinicopathological and prognostic significance of p53 protein, the expression of p53 protein was immunohistochemically examined by use of CM1, PAb1801, DO7, and DO1 antibodies on paraffin-embedded colorectal adenocarcinomas from 293 patients.	Paraffin	201-209	tumor protein p53	Homo sapiens	103-106
10783640-9	1999	The sensitivity (100%) and specificity (100%) of reactivity for Calretinin and Ber-EP4 showed that the immunocytochemical results on paraffin embedded material from cavity effusions are very reliable, so that the tested immunocytochemical panel can be useful in cytological differential diagnosis between reactive mesothelial hyperplasia/mesothelioma and metastatic carcinoma.	Paraffin	133-141	calbindin 2	Homo sapiens	64-74
10628802-1	1999	TP53 and MDM2 genes and their protein expression were evaluated in frozen and paraffin-embedded tissue from 27 patients with malignant fibrous histiocytoma to elucidate the relationship between them, their implication in tumor progression mechanisms and their possible diagnostic-prognostic value in malignant fibrous histiocytoma.	Paraffin	78-86	tumor protein p53	Homo sapiens	0-4
10633997-5	1999	METHODS: We performed double immunofluorescence staining of PRL and GH in paraffin-embedded specimens of various pituitary adenomas with subsequent observation with a confocal laser-scanning microscope.	Paraffin	74-82	growth hormone 1	Homo sapiens	68-70
10626170-4	1999	METHODOLOGY: In a retrospective case-series p53 expression was assessed using standard immunohistochemical methods in the paraffin-embedded specimens of 45 liver resections for colorectal metastases, performed in 43 patients in a single institution between "86 and "96.	Paraffin	122-130	tumor protein p53	Homo sapiens	44-47
10547596-2	1999	Cellular expression of HAP1 was determined using a standard avidin-biotin-peroxidase complex (ABC) technique and an anti-HAP1 rabbit polyclonal antibody on paraffin-embedded tissue sections from normal lung and in 103 primary non-small cell lung carcinomas (NSCLCs).	Paraffin	156-164	huntingtin associated protein 1	Homo sapiens	23-27
10541972-5	1999	MATERIALS AND METHODS: Immunostaining for E-cadherin was performed on paraffin- embedded biopsy specimens from patients with adenocarcinoma and squamous cell carcinoma of the oesophagus.	Paraffin	70-78	cadherin 1	Homo sapiens	42-52
10544251-3	1999	We have studied the level of expression of hTR and hTRT in four different models of neoplastic and preneoplastic lesions using the RT-PCR method on RNA extracted from paraffin-embedded human tissues after microdissection.	Paraffin	167-175	telomerase RNA component	Homo sapiens	43-46
10562364-3	1999	METHODS: The prognostic significance of DNA ploidy, SPF, and Pgp expression on paraffin-embedded sections from 107 patients with colorectal carcinoma was determined.	Paraffin	79-87	ATP binding cassette subfamily B member 1	Homo sapiens	61-64
10547578-1	1999	Androgen receptor (AR) gene amplification was analysed by fluorescence in situ hybridization (FISH) from 24 paraffin-embedded prostate carcinoma samples recurring locally during hormonal therapy and prostate-specific antigen (PSA) expression from 15/24 of these samples was studied by immunohistochemistry (IHC).	Paraffin	108-116	androgen receptor	Homo sapiens	0-17
10534164-4	1999	ApoE genotype was determined by nested polymerase chain reaction on genomic DNA extracted from archival paraffin-embedded materials.	Paraffin	104-112	apolipoprotein E	Homo sapiens	0-4
10564439-1	1999	We examined the expression of the transforming growth factor beta (TGF-beta) in 28 human temporomandibular joint (TMJ) samples (internal derangement of TMJ and control specimens) by an immunohistological method using paraffin-embedded tissues and a polyclonal antibody specific to human TGF-beta.	Paraffin	217-225	transforming growth factor beta 1	Homo sapiens	34-65
10360820-7	1999	This antibody reacts with the CD43 protein regardless of its glycosylation in Western blot analysis, immunoprecipitation and immuno-histochemistry of paraffin sections.	Paraffin	150-158	sialophorin	Homo sapiens	30-34
10564439-1	1999	We examined the expression of the transforming growth factor beta (TGF-beta) in 28 human temporomandibular joint (TMJ) samples (internal derangement of TMJ and control specimens) by an immunohistological method using paraffin-embedded tissues and a polyclonal antibody specific to human TGF-beta.	Paraffin	217-225	transforming growth factor beta 1	Homo sapiens	67-75
10451492-3	1999	Polymerase chain reaction (PCR) amplification of the highly polymorphic human androgen receptor gene (HUMARA) was performed on the DNA extracted from the paraffin-embedded lesional tissue microdissected to sample the admixed smooth muscle and blood vessel component (SMC/BV) and the adipose tissue component.	Paraffin	154-162	androgen receptor	Homo sapiens	78-95
10451492-3	1999	Polymerase chain reaction (PCR) amplification of the highly polymorphic human androgen receptor gene (HUMARA) was performed on the DNA extracted from the paraffin-embedded lesional tissue microdissected to sample the admixed smooth muscle and blood vessel component (SMC/BV) and the adipose tissue component.	Paraffin	154-162	androgen receptor	Homo sapiens	102-108
10404098-5	1999	In situ hybridization was performed to evaluate telomerase-RNA (hTR) expression in the corresponding paraffin-embedded tumors.	Paraffin	101-109	telomerase RNA component	Homo sapiens	64-67
10459542-6	1999	P53 mutations were analyzed on DNA extracted from paraffin-embedded specimens with use of single strand conformation polymorphism, followed by direct sequencing.	Paraffin	50-58	tumor protein p53	Homo sapiens	0-3
10497849-1	1999	Currently, the immunohistochemical evaluation of cytotoxic granule-associated proteins such as TIA-1 and granzyme B can be carried out on paraffin sections.	Paraffin	138-146	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	95-100
10511809-0	1999	[Utility of the paraffin-embedded section method on the detection of estrogen receptor from breast cancer tissues--comparison of the paraffin-embedded section method (6F11 and 1D5) with frozen section (H222) and dextran-coated charcoal (DCC) ones].	Paraffin	16-24	estrogen receptor 1	Homo sapiens	69-86
10518106-5	1999	METHODS: p53 expression in formalin-fixed, paraffin-embedded samples of 239 patients with primary esophageal squamous cell carcinoma (TNM stage I:79 cases, stage II: 82 cases, stage III: 78 cases), who underwent esophageal resection without additional treatment, were analyzed by immunohistochemical staining using a polyclonal antibody, RSP53.	Paraffin	43-51	tumor protein p53	Homo sapiens	9-12
10427139-5	1999	Sequence analysis of exons 5 through 8 of p53 was performed on subcloned PCR-amplified DNA, extracted from formalin-fixed, paraffin-embedded tumors.	Paraffin	123-131	tumor protein p53	Homo sapiens	42-45
10432193-2	1999	Thus, we examined the expression of CD34 in 20 human temporomandibular joint (TMJ) samples with internal derangement and in 10 control specimens by an immunohistological technique using paraffin-embedded tissue and specific anti-human CD34 monoclonal antibody.	Paraffin	186-194	CD34 molecule	Homo sapiens	36-40
12541358-2	1999	METHOD: The immuno-histochemical LSAB method was used to analyse the ER and PR in paraffin section specimen of 71 cases of nasopharyngeal carcinoma.	Paraffin	82-90	estrogen receptor 1	Homo sapiens	69-71
10511809-12	1999	Among these methods of ER detection from breast cancer tissues, the paraffin-embedded section method seemed to be the most useful.	Paraffin	68-76	estrogen receptor 1	Homo sapiens	23-25
11869534-2	1999	METHODS: Reverse transcription-polymerase chain reaction (RT-PCR) and citric acid-microwave-ABC immunohistochemistry (ICH) were used to observe mRNA transcription forms and protein distributions of bcl-x in 30 frozen tissues and 109 paraffin embedded tissues (both including reactive hyperplasia and common types of lymphoma).	Paraffin	233-241	BCL2 like 1	Homo sapiens	198-203
10360820-8	1999	Immuno-histochemical analysis of paraffin sections from colon adenoma and carcinoma tissues as well as colon cancer cell lines revealed that CD43 was predominantly localised intracellularly, in contrast to leukocyte-type cells.	Paraffin	33-41	sialophorin	Homo sapiens	141-145
10383711-6	1999	Using immunohistochemistry, we studied the expression of the FGF-1 and FGF-2 proteins in archival, paraffin-embedded tissue that was available from 17 oesophageal resection specimens that included OAs and OA precursor lesions.	Paraffin	99-107	fibroblast growth factor 1	Homo sapiens	61-66
10629648-5	1999	Mutant p53 protein IHC overexpression was examined from paraffin embedded tissues using monoclonal DO-7 Ab.	Paraffin	56-64	tumor protein p53	Homo sapiens	7-10
10424737-5	1999	Using immunohistochemistry, we detected VEGF, MMP-9 and E-cadherin expression in paraffin-embedded specimens of oesophageal squamous cell carcinoma.	Paraffin	81-89	vascular endothelial growth factor A	Homo sapiens	40-44
10424737-5	1999	Using immunohistochemistry, we detected VEGF, MMP-9 and E-cadherin expression in paraffin-embedded specimens of oesophageal squamous cell carcinoma.	Paraffin	81-89	cadherin 1	Homo sapiens	56-66
10430278-0	1999	Desmoplastic small round-cell tumor of the paratesticular region: report of an adult case with demonstration of EWS and WT1 gene fusion using paraffin-embedded tissue.	Paraffin	142-150	WT1 transcription factor	Homo sapiens	120-123
10483067-2	1999	MATERIALS AND METHODS: The expression of p53 and MDM2 proteins was determined immunohistochemically in 51 formalin-fixed, paraffin embedded specimens of odontogenic cysts and tumours.	Paraffin	122-130	tumor protein p53	Homo sapiens	41-44
10456688-5	1999	Developed, therefore, is a quantitative, image-analysis-based immunohistochemical technique for the analysis of GSTM1 protein in paraffin-embedded tissue samples.	Paraffin	129-137	glutathione S-transferase mu 1	Homo sapiens	112-117
10383150-4	1999	The expression of cyclin A was determined by immunohistochemistry in paraffin sections of 126 soft tissue sarcomas.	Paraffin	69-77	cyclin A2	Homo sapiens	18-26
10554161-13	1999	CONCLUSIONS: The procedures described can be used for processing of archival paraffin-embedded mammary tumors for monitoring of ER expression and aneuploidy.	Paraffin	77-85	estrogen receptor 1	Homo sapiens	128-130
10357417-5	1999	METHODS: The expression of YB-1 in the nucleus was examined immunohistochemically in 42 paraffin embedded primary Stage III (International Federation of Gynecology and Obstetrics) serous ovarian carcinoma tumors extirpated by primary surgery at Kyushu University Hospital between 1985-1995.	Paraffin	88-96	Y-box binding protein 1	Homo sapiens	27-31
10375432-3	1999	Paraffin sections fixed in Bouin-Hollande solution were immunostained with rabbit antiserum against VIP.	Paraffin	0-8	vasoactive intestinal peptide	Homo sapiens	100-103
10365929-12	1999	Immunohistochemical analysis on paraffin sections using a large panel of antibodies (16 lesions: AML: 13; CML: 3) showed strong reactivity for LCA (CD45), lysozyme, myeloperoxidase (MPD), LN2 (CD74), HLA-DR, and MT1 (CD43) in the majority of cases, and variable staining for monocyte/macrophage markers (KP1/CD68, PGM1/CD68, Mac387, Ki-M1p).	Paraffin	32-40	myeloperoxidase	Homo sapiens	165-180
10366466-3	1999	The expression of VEGF was immunohistochemically evaluated by polyclonal antibody anti-VEGF (Santa Cruz, CA, dilution 1:100) on formalin-fixed paraffin-embedded tissue.	Paraffin	143-151	vascular endothelial growth factor A	Homo sapiens	18-22
10374774-2	1999	WT1 allelic integrity was examined by loss of heterozygosity (LOH) studies in formalin-fixed, paraffin-embedded (FFPE) ductal carcinoma in situ (DCIS, n = 20) and fresh frozen primary invasive breast carcinomas (n = 24).	Paraffin	94-102	WT1 transcription factor	Homo sapiens	0-3
10374780-3	1999	This study retrospectively evaluates bcl-2 and bcl-x immunostaining in paraffin-embedded materials in gangliogliomas.	Paraffin	71-79	BCL2 apoptosis regulator	Homo sapiens	37-42
10374780-3	1999	This study retrospectively evaluates bcl-2 and bcl-x immunostaining in paraffin-embedded materials in gangliogliomas.	Paraffin	71-79	BCL2 like 1	Homo sapiens	47-52
10326701-4	1999	Expression of VEGF and MMP2 was evaluated immunohistochemically by polyclonal antibody anti-VEGF (dilution, 1:100) and affinity purified, rabbit anti-MMP2, formalin fixed, paraffin embedded tissue.	Paraffin	172-180	vascular endothelial growth factor A	Homo sapiens	14-18
10561207-5	1999	Expression of BAG-1 was determined by immunohistochemical staining of paraffin-embedded breast tumor tissues.	Paraffin	70-78	BAG cochaperone 1	Homo sapiens	14-19
10360677-10	1999	CEA levels measured by RILG, in cryostat (n = 15) and paraffin (n = 19) sections from colorectal cancer patients showed a range of CEA concentration (38.9-594 ng g(-1) and 22.5-212.5 ng g(-1) respectively).	Paraffin	54-62	CEA cell adhesion molecule 3	Homo sapiens	131-134
10226061-5	1999	Immunohistochemical analysis of resin- or paraffin-embedded sections from surgical specimens of bronchial mucosa revealed strong membrane staining for EGFR within the bronchial epithelium; this was particularly evident between basal cells and the basal aspect of columnar cells.	Paraffin	42-50	epidermal growth factor receptor	Homo sapiens	151-155
10470136-2	1999	Immunohistochemical techniques were used to demonstrate the presence of growth hormone receptors in 126 formalin-fixed, paraffin-embedded melanocytic tumours comprising melanocytic naevi, superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma and metastatic melanomas.	Paraffin	120-128	growth hormone 1	Homo sapiens	72-86
10326590-6	1999	We examined TP53 protein expression from paraffin-embedded colon tissue of the patient with an immunohistochemical method.	Paraffin	41-49	tumor protein p53	Homo sapiens	12-16
10334533-3	1999	PATIENTS AND METHODS: ER status was evaluated in 1,982 primary breast cancers by IHC on formalin-fixed paraffin-embedded tissue sections, using antibody 6F11 and standard methodology.	Paraffin	103-111	estrogen receptor 1	Homo sapiens	22-24
10349985-4	1999	bcl-2 and p53 protein expression were demonstrated by immunohistochemical methods, using formalin-fixed, paraffin-embedded biopsy tissues.	Paraffin	105-113	BCL2 apoptosis regulator	Homo sapiens	0-5
10405909-6	1999	MATERIALS AND METHODS: The expression of TGF beta was detected immunohistochemically in slide-mounted thin sections (4 microns) cut from paraffin-blocked adult UPJ segments obtained during primary pyeloplasty (N = 11), secondary pyeloplasty after failed endopyelotomy with documented crossing vessels (N = 10), secondary pyeloplasty after failed endopyelotomy without crossing vessels (N = 11), and normal UPJs removed during nephrectomy for purposes unrelated to obstruction (N = 11).	Paraffin	137-145	transforming growth factor beta 1	Homo sapiens	41-49
10349985-4	1999	bcl-2 and p53 protein expression were demonstrated by immunohistochemical methods, using formalin-fixed, paraffin-embedded biopsy tissues.	Paraffin	105-113	tumor protein p53	Homo sapiens	10-13
10201006-9	1999	Nonradioactive in situ hybridization studies on sections from formalin-fixed and paraffin-embedded, normally concentrating kidneys showed strong expression of BGT, SMIT, and AR mRNAs in interstitial and collecting duct cells of the papilla, whereas expression of SDH mRNA was much weaker in both cell types.	Paraffin	81-89	aldo-keto reductase family 1 member B	Homo sapiens	174-176
10494109-7	1999	We have examined regional and cell-type-specific expression of Prx-I and Prx-II in paraffin sections of human brain using immunohistochemical methods.	Paraffin	83-91	peroxiredoxin 2	Homo sapiens	73-79
10560479-10	1999	CONCLUSION: The incidence of c-erbB-2 expression in fresh cytologic material is significantly higher (P &lt; .05) than in formalin-fixed, paraffin-embedded tissue.	Paraffin	138-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-37
10621843-3	1999	p53 protein expression was evaluated by immunohistochemical analysis on paraffin-embedded sections of 62 representative oral cancer biopsies and 22 leukoplakias, using p53-specific monoclonal antibody DO-7.	Paraffin	72-80	tumor protein p53	Homo sapiens	0-3
10199466-5	1999	In a series of 94 examined cases of HD, we identified 9 CD21-positive ones (4 of 37 cases of nodular sclerosis, 1 of 41 mixed cellularity, and 4 of 12 lymphocyte depletion HD) without any other B-cell marker on paraffin sections.	Paraffin	211-219	complement C3d receptor 2	Homo sapiens	56-60
10201006-9	1999	Nonradioactive in situ hybridization studies on sections from formalin-fixed and paraffin-embedded, normally concentrating kidneys showed strong expression of BGT, SMIT, and AR mRNAs in interstitial and collecting duct cells of the papilla, whereas expression of SDH mRNA was much weaker in both cell types.	Paraffin	81-89	sorbitol dehydrogenase	Homo sapiens	263-266
10098760-10	1999	We conclude that in paraffin archival material, calculation of SPF according to Baisch is preferable in clinical use due to better separation between low-risk and high-risk groups, and also the possibility to identify patients who metastasize late.	Paraffin	20-28	SEC14 like lipid binding 2	Homo sapiens	63-66
10408787-0	1999	Comprehensive TP53-denaturing gradient gel electrophoresis mutation detection assay also applicable to archival paraffin-embedded tissue.	Paraffin	112-120	tumor protein p53	Homo sapiens	14-18
10424405-5	1999	S-phase fraction (SPF) was measured flowcytometrically in paraffin sections.	Paraffin	58-66	SEC14 like lipid binding 2	Homo sapiens	18-21
10408787-4	1999	When testing the assay on DNA from cultured lung cancer cell lines and from paraffin-embedded Dukes C colorectal carcinomas, significant TP53 mutations were observed at high frequencies in 15 of 16 lung cancer cell lines (94%) and in 21 of 30 paraffin-embedded tissue samples of Dukes C colorectal carcinomas (70%).	Paraffin	76-84	tumor protein p53	Homo sapiens	137-141
10408787-4	1999	When testing the assay on DNA from cultured lung cancer cell lines and from paraffin-embedded Dukes C colorectal carcinomas, significant TP53 mutations were observed at high frequencies in 15 of 16 lung cancer cell lines (94%) and in 21 of 30 paraffin-embedded tissue samples of Dukes C colorectal carcinomas (70%).	Paraffin	243-251	tumor protein p53	Homo sapiens	137-141
9915473-7	1999	Using the same iNOS antibody, the distribution of iNOS was examined in formalin-fixed, paraffin embedded samples of various grades of TCC.	Paraffin	87-95	nitric oxide synthase 2	Homo sapiens	50-54
12938516-1	1999	To understand the relationship between expression of P53 protein and HPV16/18 infection in laryngeal papillomas, PCR and immunohistochemical techniques were used to examine the paraffin-embedded tissue samples of laryngeal papillomas from 35 subjects.	Paraffin	177-185	tumor protein p53	Homo sapiens	53-56
10071687-3	1999	Immunostaining for p53 protein was performed on paraffin and frozen sections from 61 patients with different grades of meningiomas using monoclonal antibodies (mAbs) DO-1 and pAb240.	Paraffin	48-56	tumor protein p53	Homo sapiens	19-22
9916928-1	1999	Expression of protein kinase C (PKC) isoenzymes -alpha, -beta, -delta, -epsilon, -gamma, -iota, -lambda, -mu, -theta, and -zeta, and of their common receptor for activated C-kinase (RACK)-1, was determined immunohistochemically using specific antibodies in formalin-fixed and paraffin-embedded specimens of early prostatic adenocarcinomas (n = 23) obtained at radical prostatectomy.	Paraffin	276-284	protein kinase C alpha	Homo sapiens	32-35
9989450-6	1999	In immunohistochemical protocols on paraffin embedded tissue, antibodies to both tuberin and hamartin prominently labelled atypical and dysmorphic neuroglial cells that are a defining feature of TSC tubers.	Paraffin	36-44	TSC complex subunit 1	Homo sapiens	93-101
9895334-0	1999	Identification of MEN1 mutations in sporadic enteropancreatic neuroendocrine tumors by analysis of paraffin-embedded tissue.	Paraffin	99-107	menin 1	Homo sapiens	18-22
9895334-3	1999	This study describes techniques used to identify mutations in the MEN1 gene in DNA extracted from paraffin-preserved tissue.	Paraffin	98-106	menin 1	Homo sapiens	66-70
9895334-4	1999	Two novel mutations are identified in the MEN1 gene from nine archived paraffin-embedded neuroendocrine tumors, demonstrating that retrospective genetic analysis can be used to identify mutations in the MEN1 gene from preserved tissue.	Paraffin	71-79	menin 1	Homo sapiens	42-46
9895334-5	1999	Conditions are provided by which paraffin-embedded tissue can be used as a source of genetic material for sequence information of sufficient quality for mutational studies of the MEN1 gene.	Paraffin	33-41	menin 1	Homo sapiens	179-183
9934586-6	1999	CONCLUSIONS: Our results indicate that overexpression of c-erbB-2 oncoprotein is easily identifiable by immunohistochemistry in paraffin sections of certain thyroid tumours after applying an antigen retrieval method.	Paraffin	128-136	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-65
10436692-6	1999	Immunohistochemical gene Bcl-2 protein expression was determined in paraffin included pathological slices.	Paraffin	68-76	BCL2 apoptosis regulator	Homo sapiens	25-30
9894462-0	1999	Immunohistochemical detection of CD10 with monoclonal antibody 56C6 on paraffin sections.	Paraffin	71-79	membrane metalloendopeptidase	Homo sapiens	33-37
9894462-1	1999	We tested a total of 174 paraffin-embedded hematolymphoid neoplasias to determine whether CD10 can be specifically and sensitivity detected on paraffin sections using monoclonal antibody 56C6 after epitope retrieval.	Paraffin	143-151	membrane metalloendopeptidase	Homo sapiens	90-94
9894462-7	1999	CD10 is reliably detectable with antibody 56C6 on paraffin sections using epitope retrieval.	Paraffin	50-58	membrane metalloendopeptidase	Homo sapiens	0-4
9916921-0	1999	NCL-CD10-270: a new monoclonal antibody recognizing CD10 in paraffin-embedded tissue.	Paraffin	60-68	membrane metalloendopeptidase	Homo sapiens	4-8
9916921-0	1999	NCL-CD10-270: a new monoclonal antibody recognizing CD10 in paraffin-embedded tissue.	Paraffin	60-68	membrane metalloendopeptidase	Homo sapiens	52-56
9916921-5	1999	We have used a recombinant protein corresponding to the whole of CD10 to generate a monoclonal antibody that is effective in paraffin-embedded tissue sections.	Paraffin	125-133	membrane metalloendopeptidase	Homo sapiens	65-69
10228798-4	1999	METHODOLOGY: The expression of E-cadherin was evaluated in 57 formalin-fixed, paraffin-embedded specimens of colorectal cancer by immunohistochemistry.	Paraffin	78-86	cadherin 1	Homo sapiens	31-41
10690631-3	1999	The positive clones selected by ELISA were found to exhibit strong staining of nuclear p53 in both fresh and archival paraffin embedded breast tumour tissue sections.	Paraffin	118-126	tumor protein p53	Homo sapiens	87-90
10335877-1	1999	To estimate the age of skin wounds, the endothelial adhesion molecule VCAM-1 (CD 106) was detected in paraffin sections after autoclaving and using the ABC technique.	Paraffin	102-110	vascular cell adhesion molecule 1	Homo sapiens	70-76
10335877-1	1999	To estimate the age of skin wounds, the endothelial adhesion molecule VCAM-1 (CD 106) was detected in paraffin sections after autoclaving and using the ABC technique.	Paraffin	102-110	vascular cell adhesion molecule 1	Homo sapiens	78-84
9926866-1	1998	BcL-xL and Bcl-2 proteins were identified by paraffin section immunohistochemistry in the neuropil core of the barrelettes of the caudalis spinal trigeminal nucleus 6 h after birth.	Paraffin	45-53	B cell leukemia/lymphoma 2	Mus musculus	11-16
10714205-5	1999	In gastric carcinoma specimens known to express mutant E-cadherin messenger RNA these monoclonal antibodies target exclusively tumor cells in routine formalin fixed and paraffin embedded material from biopsies, primary tumors and lymph node metastases.	Paraffin	169-177	cadherin 1	Homo sapiens	55-65
11397270-1	1999	The expression of p53 protein was investigated in eight formalin-fixed, paraffin-embedded conjunctival squamous cell carcinomas of five horses and one cow, dog and cat each by an immunohistochemical procedure in order to evaluate protein overexpression.	Paraffin	72-80	tumor protein p53	Equus caballus	18-21
9950165-11	1999	Accordingly, CENP-F seems to be a useful proliferation marker for formalin-fixed and paraffin-embedded material.	Paraffin	85-93	centromere protein F	Homo sapiens	13-19
10363822-1	1999	The developmental expression pattern of the carbohydrate epitope CD15 (Lewis X, Le X) (alpha1--&gt;3-fucosyl-N-acetyl-lactosamine) has been immunocytochemically evaluated in paraffin sections within the human basal ganglia from 10 weeks gestation to three years after birth.	Paraffin	174-182	fucosyltransferase 4	Homo sapiens	65-69
9885382-0	1999	Frequent amplification of C-erbB2 (HER-2/Neu) oncogene in cervical carcinoma as detected by non-fluorescence in situ hybridization technique on paraffin sections.	Paraffin	144-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	26-33
9885382-0	1999	Frequent amplification of C-erbB2 (HER-2/Neu) oncogene in cervical carcinoma as detected by non-fluorescence in situ hybridization technique on paraffin sections.	Paraffin	144-152	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-44
9885382-8	1999	The results of the present study showed frequent amplification of C-erbB2 in cervical carcinoma on paraffin sections.	Paraffin	99-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	66-73
9870098-1	1998	OBJECTIVE: To describe the laser scanning cytometry (LSC) processing and analysis developed for the quantitative analysis of estrogen receptor (ER) content in routine paraffin sections of breast carcinomas.	Paraffin	167-175	estrogen receptor 1	Homo sapiens	125-142
9870098-1	1998	OBJECTIVE: To describe the laser scanning cytometry (LSC) processing and analysis developed for the quantitative analysis of estrogen receptor (ER) content in routine paraffin sections of breast carcinomas.	Paraffin	167-175	estrogen receptor 1	Homo sapiens	144-146
9951940-3	1998	METHODOLOGY: The expression of E-cadherin was evaluated in 83 formalin-fixed, paraffin-embedded specimens of gastric cancer by immunohistochemistry.	Paraffin	78-86	cadherin 1	Homo sapiens	31-41
9871990-4	1998	Tissue specimens were collected 12-14 h postmortem and investigated for fibronectin on paraffin sections (alkaline phosphatase and monoclonal anti-alkaline phosphatase procedure).	Paraffin	87-95	fibronectin 1	Homo sapiens	72-83
10197079-8	1998	Immunohistochemistry (IHC) for erbB-2 protein expression in corresponding paraffin-embedded samples was evaluated.	Paraffin	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-37
9862580-3	1998	p16 protein expression was evaluated immunohistochemically on paraffin sections using monoclonal and polyclonal anti-p16 antibodies, and by immunoblotting of tumour cell suspensions.	Paraffin	62-70	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-3
9886570-3	1998	Exons 5-8 of the p53 gene were examined for mutations by the polymerase chain reaction-single strand conformation polymorphism technique and DNA sequencing, using DNA from formalin-fixed paraffin-embedded tissues.	Paraffin	187-195	tumor protein p53	Homo sapiens	17-20
9929161-1	1998	bcl-2 expression was examined on paraffin-embedded specimens in proliferative, hyperplastic, and neoplastic human endometrium by immunohistochemistry.	Paraffin	33-41	BCL2 apoptosis regulator	Homo sapiens	0-5
9891464-2	1998	We evaluated E-cadherin expression immunohistochemically in 43 formalin-fixed, paraffin-embedded specimens of pancreatic cancer and investigated its relationship to histopathological features.	Paraffin	79-87	cadherin 1	Homo sapiens	13-23
9820167-3	1998	HAP1 expression levels were determined after staining of formalin-fixed paraffin-embedded tumour sections with a rabbit antiserum raised against recombinant HAP1.	Paraffin	72-80	huntingtin associated protein 1	Homo sapiens	0-4
9784320-3	1998	p53 expression was studied in archival paraffin-embedded tissue by immunohistochemistry.	Paraffin	39-47	tumor protein p53	Homo sapiens	0-3
9800799-5	1998	Expression of HER-2/neu in paraffin-embedded tumor samples was determined by immunohistochemistry and scored with a semiquantitative method.	Paraffin	27-35	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-23
9788259-6	1998	These results were confirmed by immunohistochemistry, but a relatively higher frequency of c-Met expression was detected in adenomatous goiters (25%), follicular adenoma (44%) and papillary carcinoma (100%) using formalin-fixed and paraffin-embedded materials.	Paraffin	232-240	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	91-96
9924428-5	1998	Currently available antibodies against CD79a, in particular JCB117, allow the identification of B cells, and hence B lymphoblastic disease, in paraffin-embedded material.	Paraffin	143-151	CD79a molecule	Homo sapiens	39-44
9893752-2	1998	This procedure greatly improved the detection rate of the p24 and gp41 HIV surface antigens in formalin fixed, paraffin wax embedded, HIV positive central nervous system (CNS) tissue while restricting staining to areas of the CNS showing evidence of neuropathology.	Paraffin	111-123	transmembrane p24 trafficking protein 2	Homo sapiens	58-61
9732201-4	1998	METHODS: The expression of p21 protein was immunohistochemically analysed in paraffin-embedded specimens of 186 patients with primary transitional cell bladder tumours.	Paraffin	77-85	cyclin dependent kinase inhibitor 1A	Homo sapiens	27-30
9893638-0	1998	Expression of MDR1 mRNA and encoding P-glycoprotein in archival formalin-fixed paraffin-embedded gall bladder cancer tissues.	Paraffin	79-87	ATP binding cassette subfamily B member 1	Homo sapiens	14-18
9758366-4	1998	Therefore, we performed a survey of bcl-2 expression in 778 cases of NHL using immunohistochemical techniques applied to routinely processed and paraffin-embedded tissues.	Paraffin	145-153	BCL2 apoptosis regulator	Homo sapiens	36-41
9796260-1	1998	In a case histologically proven prostatic ductal adenocarcinoma with endometrioid features associated with rectal invasion and multiple liver metastases the expression of prostate specific antigen (PSA) and carcinoembryonic antigen (CEA) was studied immunohistochemically on paraffin sections to clarify markedly elevated PSA and relatively elevated CEA in sera.	Paraffin	275-283	CEA cell adhesion molecule 3	Homo sapiens	171-237
9796260-1	1998	In a case histologically proven prostatic ductal adenocarcinoma with endometrioid features associated with rectal invasion and multiple liver metastases the expression of prostate specific antigen (PSA) and carcinoembryonic antigen (CEA) was studied immunohistochemically on paraffin sections to clarify markedly elevated PSA and relatively elevated CEA in sera.	Paraffin	275-283	CEA cell adhesion molecule 3	Homo sapiens	233-236
9769126-1	1998	We have analysed the expression of bcl-2 protein retrospectively in 34 primary male breast carcinomas (MBC), using the monoclonal antibody bcl-2 in formalin-fixed, paraffin-embedded tissues.	Paraffin	164-172	BCL2 apoptosis regulator	Homo sapiens	35-40
9792280-4	1998	We have applied cyanogen bromide cleavage, a technique used routinely for fragmenting proteins for sequencing experiments, to solubilize transferrin polypeptides and glycopolypeptides from formalin-fixed, paraffin wax-embedded rat liver.	Paraffin	205-217	transferrin	Rattus norvegicus	137-148
9828839-1	1998	Transient transfection of COS-1 cells followed by fixation, embedding in paraffin, and immunohistochemistry has identified anti-vascular endothelial growth factor (anti-VEGF) mouse monoclonal antibodies that efficiently immunostain VEGF in paraffin-embedded tissue sections.	Paraffin	240-248	vascular endothelial growth factor A	Homo sapiens	169-173
9828839-7	1998	This study has shown that the commercially available anti-VEGF monoclonal antibody M293 is excellent for the immunohistochemical localization of VEGF in paraffin sections.	Paraffin	153-161	vascular endothelial growth factor A	Homo sapiens	58-62
9828839-7	1998	This study has shown that the commercially available anti-VEGF monoclonal antibody M293 is excellent for the immunohistochemical localization of VEGF in paraffin sections.	Paraffin	153-161	vascular endothelial growth factor A	Homo sapiens	145-149
9736404-3	1998	The aim of this study was to investigate the expression of p16 and Rb proteins by immunohistochemistry using 98 formalin-fixed and paraffin-embedded samples of various cervical neoplastic lesions.	Paraffin	131-139	cyclin dependent kinase inhibitor 2A	Homo sapiens	59-62
9655287-4	1998	Histopathologic/genetic analysis of p53 was performed on formalin fixed, paraffin embedded tissues.	Paraffin	73-81	tumor protein p53	Homo sapiens	36-39
9737788-7	1998	ILK may be a sensitive and specific immunohistochemical marker and useful for the positive identification of ES and PNET in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	140-148	integrin linked kinase	Homo sapiens	0-3
9873831-0	1998	Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers.	Paraffin	45-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	15-20
9698472-2	1998	Immunostaining for p53 protein was performed on formalin-fixed, paraffin-embedded sections from 158 patients with verified uterine sarcomas using monoclonal p53 antibody (DO-1).	Paraffin	64-72	tumor protein p53	Homo sapiens	19-22
9873831-0	1998	Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers.	Paraffin	45-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	22-26
9873831-0	1998	Alterations of CDKN2 (MTS1/p16INK4A) gene in paraffin-embedded tumor tissues of human stomach, lung, cervix and liver cancers.	Paraffin	45-53	cyclin dependent kinase inhibitor 2A	Homo sapiens	27-35
9626345-7	1998	Immunohistochemical analyses of formalin-fixed paraffin-embedded sections of tissues with specific antibodies revealed a prevalent cytoplasmic cyclin E staining in the thyroid tissues analyzed.	Paraffin	47-55	cyclin E1	Rattus norvegicus	143-151
9650754-1	1998	Using immunohistochemistry we evaluated the expression of two negative regulators of the cell cycle, the retinoblastoma gene product (pRb) and the WAF1/Cip1 gene product (p21), in consecutive paraffin sections from 54 gliomas (49 astrocytomas and 5 oligodendrogliomas) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival.	Paraffin	192-200	cyclin dependent kinase inhibitor 1A	Homo sapiens	147-151
9620022-5	1998	Paraffin sections of 9 reactive lymph nodes and 43 low-grade and 60 high-grade malignant lymphomas were reacted with antibodies against pRB and p16.	Paraffin	0-8	cyclin dependent kinase inhibitor 2A	Homo sapiens	144-147
9650754-1	1998	Using immunohistochemistry we evaluated the expression of two negative regulators of the cell cycle, the retinoblastoma gene product (pRb) and the WAF1/Cip1 gene product (p21), in consecutive paraffin sections from 54 gliomas (49 astrocytomas and 5 oligodendrogliomas) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival.	Paraffin	192-200	cyclin dependent kinase inhibitor 1A	Homo sapiens	171-174
9771440-2	1998	METHODS: The immunoperoxidase technique with an antibody directed against eNOS was applied to paraffin sections from first and second trimester placentas, placenta accreta, partial and complete hydatidiform moles, and choriocarcinoma.	Paraffin	94-102	nitric oxide synthase 3	Homo sapiens	74-78
9836068-7	1998	This method is applicable to DNA from fresh frozen tissues, and, after the TcR beta rearrangement of a patient"s malignant T-cell clone has been identified by the screening PCR, DNA can also be detected in follow-up formalin-fixed paraffin-embedded samples by the J beta-specific PCR with high sensitivity and specificity.	Paraffin	231-239	T cell receptor beta locus	Homo sapiens	75-83
9645763-3	1998	In the present study, p53 gene mutations were analyzed on paraffin-embedded specimens from 24 patients with PRS (4 men and 20 women) by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) followed by direct sequencing.	Paraffin	58-66	tumor protein p53	Homo sapiens	22-25
10923515-2	1998	METHODS: In vitro transcriptional RNA probe labeled with biotin and in situ hybridization method were used in this study to detect p16 mRNA in the paraffin embedded tissue of human primary breast carcinoma from 120 cases.	Paraffin	147-155	cyclin dependent kinase inhibitor 2A	Homo sapiens	131-134
9638703-3	1998	Immunohistochemical analysis with monoclonal antibodies to bcl-2 oncoprotein in formalin-fixed paraffin-embedded tissue sections revealed that severe epithelial dysplasias had a higher percentage of immunoreactivity than did mild and moderate dysplasias and squamous cell carcinomas.	Paraffin	95-103	BCL2 apoptosis regulator	Homo sapiens	59-64
9595036-8	1998	Strong positive nuclear staining of the p53 protein was detected in both normal and tumor paraffin-embedded tissues.	Paraffin	90-98	tumor protein p53	Homo sapiens	40-43
9666819-4	1998	Our aim was to investigate immunohistochemically the expression of moesin together with CD44 on paraffin tissue sections of a series of melanocytic tumours.	Paraffin	96-104	moesin	Homo sapiens	67-73
10200490-1	1998	The ontogenic profile of expression of four members of the Bcl-2 family (Bcl-2, Bcl-x, Bax and Bak) was examined in the mouse by immunohistochemistry using paraffin sections.	Paraffin	156-164	B cell leukemia/lymphoma 2	Mus musculus	59-64
9596274-0	1998	Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disorders.	Paraffin	0-8	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	34-39
9570628-3	1998	METHODS: A monoclonal antibody against the c-erbB-2 oncoprotein has been used immunocytochemically in a retrospective study of formalin-fixed, paraffin-embedded samples from 28 consecutive intestinal-type adenocarcinomas (ITACs) of the nose and paranasal sinuses.	Paraffin	143-151	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-51
9797697-4	1998	Immunohistochemical expression of p53 protein was evaluated in formalin-fixed paraffin-embedded sections of CRC liver metastases using the monoclonal antibodies (MAbs) D01 and Pab 1801.	Paraffin	78-86	tumor protein p53	Homo sapiens	34-37
9596274-0	1998	Paraffin section detection of the c-kit gene product (CD117) in human tissues: value in the diagnosis of mast cell disorders.	Paraffin	0-8	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	54-59
10923439-2	1998	METHODS: Immunohistochemical method was used to detect and analyse the expression of P16 protein of CDKN2 suppressor gene of 76 cases in formalin-fixed, paraffin-embedded tissue specimens of human lung cancer.	Paraffin	153-161	cyclin dependent kinase inhibitor 2A	Homo sapiens	85-88
9579543-3	1998	p53 protein immunohistochemistry was performed on 37 paraffin embedded biopsies from 27 patients with CTCL; LCT was present in 15 biopsies.	Paraffin	53-61	tumor protein p53	Homo sapiens	0-3
9605068-3	1998	METHODS: The expression of vascular endothelial growth factor was determined by an immunohistochemical analysis from 91 paraffin specimens of completely resected non-small-cell lung cancers using anti-growth factor polyclonal antibody.	Paraffin	120-128	vascular endothelial growth factor A	Homo sapiens	27-61
9610570-4	1998	Immunohistology procedures were used to assess GRN-A expression in paraffin-embedded prostate tissue samples.	Paraffin	67-75	granulin precursor	Homo sapiens	47-50
10923439-2	1998	METHODS: Immunohistochemical method was used to detect and analyse the expression of P16 protein of CDKN2 suppressor gene of 76 cases in formalin-fixed, paraffin-embedded tissue specimens of human lung cancer.	Paraffin	153-161	cyclin dependent kinase inhibitor 2A	Homo sapiens	100-105
9546345-3	1998	In the current study, 59 cases of nasopharyngeal carcinoma were evaluated for expression of the p16 tumor suppressor protein by immunohistochemical analysis of paraffin-embedded tissue.	Paraffin	160-168	cyclin dependent kinase inhibitor 2A	Homo sapiens	96-99
9609668-0	1998	Simultaneous detection of p53 nuclear protein and chromosome aberrations on sections from formalin-fixed, paraffin-embedded breast cancer tissue.	Paraffin	106-114	tumor protein p53	Homo sapiens	26-29
9607618-9	1998	p53 mutant status was assessed immunohistochemically from sections of the formalin-fixed, paraffin-embedded pretreatment biopsy and the resected specimen.	Paraffin	90-98	tumor protein p53	Homo sapiens	0-3
9529014-5	1998	Immunohistochemical staining of the paraffin sections was performed using monoclonal antibodies to cyclin E and p53.	Paraffin	36-44	tumor protein p53	Homo sapiens	112-115
9495360-3	1998	In a comprehensive study, we analyzed p16 protein expression by immuno-histochemistry (IHC) on paraffin sections of 94 primary ovarian carcinomas of different histological subtype.	Paraffin	95-103	cyclin dependent kinase inhibitor 2A	Homo sapiens	38-41
9785008-0	1998	Detection of TLS/FUS-CHOP fusion transcripts in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues.	Paraffin	156-164	FUS RNA binding protein	Homo sapiens	13-16
9785008-2	1998	In this study, we conducted a nested reverse transcription-polymerase chain reaction (RT-PCR)-based assay to detect the TLS/FUS-CHOP fusion gene transcripts using archival formalin-fixed, paraffin-embedded tumor specimens.	Paraffin	188-196	FUS RNA binding protein	Homo sapiens	120-123
9713590-5	1998	Synthesis of p16/CDKN2 and pRb proteins was determined by immunohistochemistry in 19 specimens of formalin fixed, paraffin wax embedded tissues.	Paraffin	114-126	cyclin dependent kinase inhibitor 2A	Homo sapiens	13-16
9515788-3	1998	We analyzed p53 mutations on paraffin-embedded specimens from 21 patients with PAL by PCR-single-strand conformational polymorphism followed by direct sequencing.	Paraffin	29-37	tumor protein p53	Homo sapiens	12-15
9543338-2	1998	Using mono- and polyclonal antibodies and a digoxigenin-labeled 713 bp riboprobe, the androgen receptor expression in paraffin sections of fetal, infantile, and pubertal prostates was studied at the protein and RNA level.	Paraffin	118-126	androgen receptor	Homo sapiens	86-103
9520947-0	1998	Amplification of c-erbB-2 in gastric cancer: detection in formalin-fixed, paraffin-embedded tissue by fluorescence in situ hybridization.	Paraffin	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	17-25
9520949-5	1998	Mouse monoclonal antibody to c-Src protein was applied to 3-micron sections from formalin-fixed, paraffin-embedded tissues using the avidin-biotin-peroxidase method.	Paraffin	97-105	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	29-34
9532005-3	1998	We investigated GCDFP-15 expression in a large series of formalin-fixed, paraffin-embedded normal human adult and fetal tissues using the monoclonal antibody BRST-2.	Paraffin	73-81	prolactin induced protein	Homo sapiens	16-24
9543489-1	1998	Apolipoprotein E (APOE) genotyping of genomic DNA extracted from formaldehyde-fixed specimens is cumbersome: there is not only a low yield or failure of PCR amplification (presumably due to degradation of DNA in the formaldehyde-fixed and paraffin-embedded tissue), but the standard method also involves the separation of DNA fragments as small as 48, 72, 81 and 91 bp requiring high-yield PCR products.	Paraffin	239-247	apolipoprotein E	Homo sapiens	0-16
9682769-6	1998	p53 protein expression was evaluated by immunohistochemistry (IHC) on paraffin-embedded sections.	Paraffin	70-78	tumor protein p53	Homo sapiens	0-3
9516946-3	1998	Therefore, to test the hypothesis that HER-2/neu expression is associated with a poorer response to tamoxifen, a shorter time to treatment failure (TTF), and worse survival in estrogen receptor (ER)-positive metastatic breast cancer, we examined 205 paraffin-embedded blocks of tumors from patients enrolled on Southwest Oncology Group 8228 for HER-2/neu expression.	Paraffin	250-258	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-48
9602692-3	1998	METHODS: The immunohistochemical expression of p21WAF1/CIP1 gene was measured in 33 placentas, 28 partial hydatidiform moles, 54 complete hydatidiform moles, and 13 choriocarcinomas in paraffin wax embedded tissue.	Paraffin	185-197	cyclin dependent kinase inhibitor 1A	Homo sapiens	55-59
9510369-6	1998	Both anti-LMP and anti-TAP mAb stained keratinocytes and infiltrating lymphocytes in frozen and formalin-fixed, paraffin embedded sections of normal skin in indirect immunoperoxidase reactions.	Paraffin	112-120	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)	Mus musculus	23-26
9452263-4	1998	METHODS: The authors analyzed Cg A mRNA in 20 cases of SCLC in formalin fixed, paraffin embedded tissue using a new, highly sensitive in situ hybridization method that was developed from the maximized immunohistochemistry (ImmunoMax) method.	Paraffin	79-87	chromogranin A	Homo sapiens	30-34
9520085-6	1998	Paraffin-embedded sections from normal, pancreatitis, and cancerous human pancreatic tissue and normal, N-nitrosobis(2-oxopropyl)amine (BOP)-treated hyperplastic, and cancerous hamster pancreatic tissues were processed immunohistochemically for galectin-3 using the MAb M3/38.	Paraffin	0-8	BOP	Homo sapiens	136-139
11189425-2	1998	The LZM distribution of regional lymph nodes incised from laryngocarcinoma patients in paraffin sections was observed by immunohistochemical technique.	Paraffin	87-95	lysozyme	Homo sapiens	4-7
9510045-3	1998	MATERIALS AND METHODS: Immunostaining for p53 protein was performed on paraffin-embedded specimens from 69 patients with adeno- and squamous cell carcinoma of the oesophagus.	Paraffin	71-79	tumor protein p53	Homo sapiens	42-45
9445187-12	1998	CONCLUSIONS: In this study, p53p overexpression was infrequent in paraffin embedded melanoma specimens and independent of the primary melanoma"s anatomic site.	Paraffin	66-74	tumor protein p53	Homo sapiens	28-32
9580543-4	1998	Expression of mutant p53 was evaluated in 655 human breast carcinomas (349 node-positive and 306 node-negative patients) with long-term clinical follow-up by immunohistochemistry in sections from paraffin embedded tumors.	Paraffin	196-204	tumor protein p53	Homo sapiens	21-24
9516946-3	1998	Therefore, to test the hypothesis that HER-2/neu expression is associated with a poorer response to tamoxifen, a shorter time to treatment failure (TTF), and worse survival in estrogen receptor (ER)-positive metastatic breast cancer, we examined 205 paraffin-embedded blocks of tumors from patients enrolled on Southwest Oncology Group 8228 for HER-2/neu expression.	Paraffin	250-258	estrogen receptor 1	Homo sapiens	40-42
9615190-1	1998	Paraffin embedded and formalin fixed needle biopsies of prostate cancer (PC) were used to immunocytochemically detect the p120 nucleolar protein in relation to the Gleason histological gradings (GHG), the labelling indices of proliferating nuclear immunocytochemical markers (PCNA/Cyclin, Ki-67/MIB1) and the argyrophilic nucleolar region (AgNOR) rate.	Paraffin	0-8	NOP2 nucleolar protein	Homo sapiens	122-126
9719502-4	1998	In addition, p53 protein overexpression was assessed by immunohistochemistry using the monoclonal antibody DO-7 on paraffin-embedded tissue sections.	Paraffin	115-123	tumor protein p53	Homo sapiens	13-16
9454886-2	1998	CDKN2/p16 homozygous deletions was studied in paraffin-embedded sections of 45 astrocytic tumours by multiplex PCR.	Paraffin	46-54	cyclin dependent kinase inhibitor 2A	Homo sapiens	0-5
9728289-6	1998	To date, the ICRF in situ Hybridisation Service has hybridised over 30,000 sections of principally formalin-fixed, paraffin-embedded tissues, with a high success rate.	Paraffin	115-123	regenerating family member 1 alpha	Homo sapiens	13-17
9773296-1	1998	Immunohistochemical detection of p53 in paraffin-embedded biopsy specimens has important diagnostic, prognostic and therapeutic applications.	Paraffin	40-48	tumor protein p53	Homo sapiens	33-36
9522220-1	1998	AIMS: To study the expression of the epithelial adhesion molecule E-cadherin and its associated proteins alpha and beta catenin in paraffin sections of normal ovaries, benign cystadenomas and ovarian carcinomas, and in immortalized normal ovarian surface epithelial cells and ovarian carcinoma cells in culture.	Paraffin	131-139	cadherin 1	Homo sapiens	66-76
9416838-4	1997	In this study we addressed the possible prognostic value of the molecular alterations identified in exons 5-8 of the TP53 gene in DNAs from 151 paraffin-embedded NSCLC sections corresponding to 59 Spanish and 92 Polish stage I-IIIA resected patients.	Paraffin	144-152	tumor protein p53	Homo sapiens	117-121
9728362-0	1998	Analysis of BAX expression in human tissues using the anti-BAX, 4F11 monoclonal antibody on paraffin sections.	Paraffin	92-100	BCL2 associated X, apoptosis regulator	Homo sapiens	12-15
9728362-11	1998	This report shows the usefulness the monoclonal antibody anti-BAX 4F11 on paraffin sections and demonstrates that the human BAX tissular distribution is close to, but not similar, to the profile observed in the mouse.	Paraffin	74-82	BCL2 associated X, apoptosis regulator	Homo sapiens	62-65
15678854-6	1998	Immunohistochemical determination of p53 protein was performed on tissular samples formalin fixed and paraffin embedded, using mouse monoclonal antibody DAKO--p53 DO 7 p53 human antiprotein.	Paraffin	102-110	tumor protein p53	Homo sapiens	37-40
9793967-4	1998	In both cases, immunohistochemistry applied to paraffin sections revealed reactivity of tumor cells for CD10, 20 and 79a.	Paraffin	47-55	membrane metalloendopeptidase	Homo sapiens	104-108
9820867-6	1998	Then, the investigation of CD21 expression was performed only in the EBV-positive tumors with immunohistochemical method for CD21 antigen on paraffin sections.	Paraffin	141-149	complement C3d receptor 2	Homo sapiens	125-129
15678851-4	1998	In this study we analyzed the expression of p53 protein in a variety of salivary gland malignant tumors fixed in formalin and included in paraffin, using the method of immunohistochemical coloring with the anti-p53 DO-7 antibody.	Paraffin	138-146	tumor protein p53	Homo sapiens	44-47
9436971-0	1997	The combination of in situ hybridization and immunohistochemical analysis: an evaluation of Her2/neu expression in paraffin-embedded breast carcinomas and adjacent normal-appearing breast epithelium.	Paraffin	115-123	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-100
9389770-8	1997	Using this optimized ImmunoMax method, we were able to detect CD2, CD3, CD4, and CD5 with conventional monoclonal antibodies in formalin-fixed, paraffin-embedded tissue specimens of various lymphoid tissues.	Paraffin	144-152	CD4 molecule	Homo sapiens	72-75
9494587-2	1997	We investigated the localization of p53 protein in association with HPV in paraffin sections of 10 dysplastic and 12 malignant laryngeal squamous epithelium specimens by using immunohistochemical and in situ hybridization techniques.	Paraffin	75-83	tumor protein p53	Homo sapiens	36-39
10374328-2	1997	METHODS: The expression of p53 protein was determined in the paraffin embedded tissues of 171 cases of cervical carcinoma, 68 cases of SIL and 29 cases of chronic cervicitis, using ABC immunohistochemical method.	Paraffin	61-69	tumor protein p53	Homo sapiens	27-30
9438369-1	1997	In a case of insulin suicide in a nondiabetic woman, insulin was detected in routinely formalin fixed and paraffin embedded subcutaneous injection marks, in spite of a post-morterm interval of 24 days.	Paraffin	106-114	insulin	Homo sapiens	13-20
9438369-1	1997	In a case of insulin suicide in a nondiabetic woman, insulin was detected in routinely formalin fixed and paraffin embedded subcutaneous injection marks, in spite of a post-morterm interval of 24 days.	Paraffin	106-114	insulin	Homo sapiens	53-60
9397628-4	1997	Paraffin-embedded tissue blocks of surgical margins from 24 patients with oral cavity and oropharyngeal squamous cell carcinoma were immunostained for p53 protein.	Paraffin	0-8	tumor protein p53	Homo sapiens	151-154
9376600-2	1997	The incidence and prognostic significance of Bax protein expression in diffuse non-Hodgkin"s lymphomas with a large cell component (DLCL) was determined by an immunohistochemical method by using paraffin-embedded tumors from a cohort of patients treated uniformly with combination chemotherapy (n = 139).	Paraffin	195-203	BCL2 associated X, apoptosis regulator	Homo sapiens	45-48
9568536-1	1997	The distribution of the 3-fucosyl-N-acetyl-lactosamine (FAL, CD15) epitope in the developing mouse cerebellum was examined with the aid of immunohistochemistry of paraffin sections.	Paraffin	163-171	fucosyltransferase 4	Mus musculus	61-65
9376600-4	1997	Paraffin sections from diagnostic biopsies were successfully immunostained for Bax in 113 cases.	Paraffin	0-8	BCL2 associated X, apoptosis regulator	Homo sapiens	79-82
9390033-4	1997	In this study, the expression of the Grb2 adaptor protein was determined in both normal human breast tissue and mammary cancers, using immunoblotting experiments and immunostaining on paraffin-embedded tissue sections.	Paraffin	184-192	growth factor receptor bound protein 2	Homo sapiens	37-41
9368590-1	1997	We investigated the expression of p53 in 82 formalin-fixed, paraffin-embedded archival tissue specimens of lip and intraoral squamous cell carcinomas (SCCs) from the period 1930-1995, by immunohistochemistry using three monoclonal antibodies (MAbs DO-7, DO-1 and 1801).	Paraffin	60-68	tumor protein p53	Homo sapiens	34-37
9343323-0	1997	MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-grade lymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities.	Paraffin	41-49	CD99 molecule (Xg blood group)	Homo sapiens	0-4
9343323-0	1997	MIC2, TdT, bcl-2, and CD34 expression in paraffin-embedded high-grade lymphoma/acute lymphoblastic leukemia distinguishes between distinct clinicopathologic entities.	Paraffin	41-49	CD34 molecule	Homo sapiens	22-26
9290950-4	1997	The expression of p53 was determined by immunohistochemistry in 19 pheochromocytomas and in 17 MTCs using two antibodies (D01 and D07) on frozen and paraffin-embedded tissues.	Paraffin	149-157	tumor protein p53	Homo sapiens	18-21
9815833-1	1997	Expression of the p16 gene product in human primary pancreatic carcinoma (PC) was investigated in paraffin-embedded tissue using a monoclonal antibody against p16 protein, clone G175-405, by means of immunohistochemistry, and the correlation of results with various clinicopathological parameters was evaluated.	Paraffin	98-106	cyclin dependent kinase inhibitor 2A	Homo sapiens	18-21
10325638-1	1997	To explore the carcinogenic effect of asbestos at molecular level, we directly analyzed the mutations of exon 5, 7 and 8 of anti-oncogene p53 in paraffin-embedded human lung tissue affected by asbestos for the first time.	Paraffin	145-153	tumor protein p53	Homo sapiens	138-141
18470734-3	1997	It is only immunohistology (CD20, CD43, CD68) of the paraffin blocks from the resection specimen that can lead to the final diagnosis of intermediate grade malignant lymphoma.	Paraffin	53-61	keratin 20	Homo sapiens	28-32
9561622-2	1997	The amplification of HER-2/neu oncogene in the DNA of paraffin-embedded specimens was determined by differential PCR.	Paraffin	54-62	erb-b2 receptor tyrosine kinase 2	Homo sapiens	21-30
9413739-0	1997	Immunohistochemical detection of nucleolar protein p120 in paraffin-embedded tissues.	Paraffin	59-67	NOP2 nucleolar protein	Homo sapiens	51-55
9413739-3	1997	In the present study, a reliable immunostaining method was used to detect p120 on formalin-fixed, paraffin wax-embedded tissue, testing it on 148 samples from different neoplastic and non-neoplastic tissues from different organs (breast, colon, lung, prostate, bladder, lymph nodes, skin, tongue and liver).	Paraffin	98-110	NOP2 nucleolar protein	Homo sapiens	74-78
9413739-6	1997	Our results show that the nucleolar protein p120 can be detected by routine immunohistochemistry in formalin-fixed, paraffin-embedded tissue and is expressed in all nucleated cells under any biological condition.	Paraffin	116-124	NOP2 nucleolar protein	Homo sapiens	44-48
9250154-2	1997	An immunohistochemical method using polyclonal antibodies against ornithine transcarbamylase visualized the mosaicism in serial paraffin sections.	Paraffin	128-136	ornithine transcarbamylase	Mus musculus	66-92
10920912-2	1997	METHODS: Levels of c-erbB-2 and p53 protein were detected by immunohistochemistry in 184 paraffin-embeded blocks.	Paraffin	89-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	19-27
10920912-2	1997	METHODS: Levels of c-erbB-2 and p53 protein were detected by immunohistochemistry in 184 paraffin-embeded blocks.	Paraffin	89-97	tumor protein p53	Homo sapiens	32-35
9298936-4	1997	Optimal conditions for in situ hybridization for TNF alpha mRNA in paraffin-embedded tissue were established.	Paraffin	67-75	tumor necrosis factor	Homo sapiens	49-58
9241072-4	1997	METHODS: p16 expression was determined by immunohistochemical analysis of 115 paraffin specimens of primary NSCLC that were curatively resected.	Paraffin	78-86	cyclin dependent kinase inhibitor 2A	Homo sapiens	9-12
9284204-3	1997	The immunohistochemical analysis of chromogranin A and neuron-specific enolase in formalin-fixed, paraffin wax embedded prostatic tissue chips was related to other prognostic variables and patient survival.	Paraffin	98-110	chromogranin A	Homo sapiens	36-50
9284204-3	1997	The immunohistochemical analysis of chromogranin A and neuron-specific enolase in formalin-fixed, paraffin wax embedded prostatic tissue chips was related to other prognostic variables and patient survival.	Paraffin	98-110	enolase 2	Homo sapiens	55-78
9274823-1	1997	Human immunodeficiency virus type 1 (HIV-1) infection of the brain has been demonstrated in formalin fixed, paraffin embedded post-mortem brain tissue (PM) by chromogenic immunohistochemistry for the HIV p24 antigen.	Paraffin	108-116	transmembrane p24 trafficking protein 2	Homo sapiens	204-207
9286277-3	1997	METHODS: Expression of HLA-A and -B antigens was determined on 30 formalin-fixed and paraffin-embedded sections of uveal melanoma by immunohistochemistry with locus-specific monoclonal antibodies and scored semiquantitatively.	Paraffin	85-93	major histocompatibility complex, class I, A	Homo sapiens	23-35
9339128-3	1997	To determine the bcl-2 immunoreactivity, we used a monoclonal antibody directed against the bcl-2 protein by immunohistochemistry from paraffin-embedded tissue in a series of 91 women with breast cancer.	Paraffin	135-143	BCL2 apoptosis regulator	Homo sapiens	92-97
9267826-10	1997	HER-2/neu oncogene amplification can be assessed using automated FISH on formalin-fixed, paraffin-embedded tissue.	Paraffin	89-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
9267826-10	1997	HER-2/neu oncogene amplification can be assessed using automated FISH on formalin-fixed, paraffin-embedded tissue.	Paraffin	89-97	erb-b2 receptor tyrosine kinase 2	Homo sapiens	6-9
9252718-2	1997	We determined EGF-R expression by an immunohistochemical assay on paraffin-embedded primary breast cancer tissue by means of the anti EGF-R mab E30 (Merck, FRG) and streptavidin-peroxidase technique.	Paraffin	66-74	epidermal growth factor receptor	Homo sapiens	14-19
9214672-7	1997	Mutation of the p53 gene was indicated by overexpression of p53 protein (i.e., cellular accumulation of mutant p53 protein) in paraffin-embedded ovarian cancer tissue blocks; the mutant protein was detected by means of standard immunohistochemical techniques.	Paraffin	127-135	tumor protein p53	Homo sapiens	16-19
9214672-7	1997	Mutation of the p53 gene was indicated by overexpression of p53 protein (i.e., cellular accumulation of mutant p53 protein) in paraffin-embedded ovarian cancer tissue blocks; the mutant protein was detected by means of standard immunohistochemical techniques.	Paraffin	127-135	tumor protein p53	Homo sapiens	60-63
9214672-7	1997	Mutation of the p53 gene was indicated by overexpression of p53 protein (i.e., cellular accumulation of mutant p53 protein) in paraffin-embedded ovarian cancer tissue blocks; the mutant protein was detected by means of standard immunohistochemical techniques.	Paraffin	127-135	tumor protein p53	Homo sapiens	60-63
9240173-4	1997	The expression of the MDR-1 gene product was determined immunohistochemically using the JSB-1 antibody in formalin-fixed paraffin-embedded tumour samples from these patients.	Paraffin	121-129	ATP binding cassette subfamily B member 1	Homo sapiens	22-27
21528173-3	1997	Expression of HBEC-MDGI, as detected by in situ hybridization in paraffin-embedded normal breast tissues, was maximal in the most differentiated lobules type 4, low in the moderately differentiated lobules type 3, and absent in the least differentiated lobules types 1 and 2.	Paraffin	65-73	fatty acid binding protein 3	Homo sapiens	19-23
9182597-1	1997	The developmental expression of the 3-fucosyl-N-acetyl-lactosamine (CD15, Lex, SSEA-1) epitope has been examined immunohistochemically in paraffin sections of the mouse hippocampus.	Paraffin	138-146	fucosyltransferase 4	Mus musculus	68-72
9301455-4	1997	We used monoclonal antibody 124 to investigate Bcl-2 expression in paraffin sections of 62 primary breast carcinomas.	Paraffin	67-75	BCL2 apoptosis regulator	Homo sapiens	47-52
9301456-1	1997	This short report describes the detection of mutations of the TP53 tumour suppressor gene in sporadic ovarian carcinomas using archival paraffin-embedded tissues and automated fluorescent DNA sequencing.	Paraffin	136-144	tumor protein p53	Homo sapiens	62-66
9224289-4	1997	Expression of P-selectin in the iris-ciliary body was studied by immunohistochemistry using wholemounts and paraffin embedded sections of iris-ciliary body prepared at various time intervals.	Paraffin	108-116	selectin P	Rattus norvegicus	14-24
9224289-7	1997	RESULTS: P-selectin immunoreactivities were observed in the vessels of the iris in whole iris-ciliary body mounts and on the surface of the microvascular endothelium in paraffin-embedded sections.	Paraffin	169-177	selectin P	Rattus norvegicus	9-19
9253517-4	1997	DESIGN AND METHODS: An Apo-E genotyping method was tested for use on formalin-fixed paraffin-embedded brain tissue, using semi-nested PCR followed by hybridization with biotin-labeled allele-specific oligonucleotides, and chemiluminescent detection.	Paraffin	84-92	apolipoprotein E	Homo sapiens	23-28
9812577-0	1997	[Detection of p53 gene mutation in paraffin-embedded asbestos-related lung cancer tissue].	Paraffin	35-43	tumor protein p53	Homo sapiens	14-17
9186368-1	1997	PURPOSE: To evaluate retrospectively c-erbB-2 oncogene amplification in paraffin embedded specimens of collecting duct carcinoma of the kidney (CDC) with competitive polymerase chain reaction (PCR).	Paraffin	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	37-45
9216855-4	1997	To assess the relationship between the LOH status of the p53 gene in the liver cirrhosis stage and that in HCC, we analyzed the samples microdissected from paraffin-embedded tissues using the polymerase-chain-reaction-based assay.	Paraffin	156-164	tumor protein p53	Homo sapiens	57-60
9236923-7	1997	METHODS: Expression of p53 and PCNA were detected by immunocytochemistry in paraffin-embedded sections of infiltrating duct carcinoma and control breast tissue (normal tissue and adenoma).	Paraffin	76-84	tumor protein p53	Homo sapiens	23-26
9192832-2	1997	E-CD-specific antibody 5H9 was applied to paraffin-embedded tissues.	Paraffin	42-50	cadherin 1	Homo sapiens	0-4
10680515-1	1997	To explore significance of transforming growth factor beta 1 (TGF beta 1) in the pathogenesis of oral submucous fibrosis (OSF), TGF beta 1 mRNAs in keratinocytes of the paraffin embeded tissues of 25 OSF cases, 5 normals (NOR) and 10 oral lichen planus (OLP) were determined by the in situ hybridization technique.	Paraffin	169-177	transforming growth factor beta 1	Homo sapiens	128-138
9191518-5	1997	METHODS: The authors analyzed the numeric aberrations of chromosome 17 and p53 gene deletions in 11 paraffin embedded pleomorphic adenomas (PA) and 9 carcinomas in pleomorphic adenoma (CIPA), using FISH techniques.	Paraffin	100-108	tumor protein p53	Homo sapiens	75-78
9185695-3	1997	We analyzed p53 mutations on paraffin-embedded specimens from 33 patients with AS by polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) followed by direct sequencing.	Paraffin	29-37	tumor protein p53	Homo sapiens	12-15
9179065-7	1997	p53 immunostaining was performed on paraffin embedded tissue.	Paraffin	36-44	tumor protein p53	Homo sapiens	0-3
9176382-3	1997	TIA-1 expression was evaluated by paraffin immunohistochemistry in 115 T- or NK-cell neoplasms, 45 B-cell neoplasms, and 45 Hodgkin"s lymphomas.	Paraffin	34-42	TIA1 cytotoxic granule associated RNA binding protein	Homo sapiens	0-5
9190996-12	1997	The reactivity of the cadherin-specific antibodies with antigens in paraffin sections make them powerful and reliable markers in the practice of diagnostic surgical pathology.	Paraffin	68-76	cadherin 1	Homo sapiens	22-30
9228249-1	1997	The expression of c-erbB-2 oncogene and p53 tumor suppressor gene was studied in methacarn-fixed, paraffin-embedded biopsy specimens from 58 benign breast lesions and 129 sporadic breast carcinomas, using the supersensitive monoclonal antibodies CB 11 and BP 53-12-1 and the biotin-streptAvidin-amplified methodology.	Paraffin	98-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
9292148-2	1997	This study was undertaken to evaluate four anti-WT1 antibodies and use the most specific one to examine the expression of WT1 in formalin fixed, paraffin wax embedded tissues from human embryos, fetuses, and paediatric renal neoplasms.	Paraffin	145-157	WT1 transcription factor	Homo sapiens	122-125
9378810-0	1997	A new mdr-1 encoded P-170 specific monoclonal antibody: (6/1C) on paraffin wax embedded tissue without pretreatment of sections.	Paraffin	66-78	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	6-11
9378810-0	1997	A new mdr-1 encoded P-170 specific monoclonal antibody: (6/1C) on paraffin wax embedded tissue without pretreatment of sections.	Paraffin	66-78	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Mus musculus	20-25
9378810-1	1997	AIMS: The generation and characterisation of a monoclonal antibody that specifically recognises the mdr-1 encoded protein, P-glycoprotein (P-170), on routinely processed formalin fixed, paraffin wax embedded tissue sections.	Paraffin	186-198	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	100-105
9378810-1	1997	AIMS: The generation and characterisation of a monoclonal antibody that specifically recognises the mdr-1 encoded protein, P-glycoprotein (P-170), on routinely processed formalin fixed, paraffin wax embedded tissue sections.	Paraffin	186-198	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Mus musculus	139-144
9378810-7	1997	Immunohistochemical studies on formalin fixed, paraffin wax embedded normal adult kidney, liver, and breast tissue and a range of fetal tissues exhibited staining patterns of a variety of secretory surfaces consistent with documented mdr-1 specific staining.	Paraffin	47-59	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	234-239
9378810-10	1997	CONCLUSIONS: This new monoclonal antibody, chosen for its specificity with the mdr-1 encoded P-170 and its reactivity on routinely fixed paraffin wax embedded tissue samples without pretreatment, appears to be useful for the investigation of P-170 in archival material.	Paraffin	137-149	ATP-binding cassette, sub-family B (MDR/TAP), member 1B	Mus musculus	79-84
9378810-10	1997	CONCLUSIONS: This new monoclonal antibody, chosen for its specificity with the mdr-1 encoded P-170 and its reactivity on routinely fixed paraffin wax embedded tissue samples without pretreatment, appears to be useful for the investigation of P-170 in archival material.	Paraffin	137-149	phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 alpha	Mus musculus	93-98
9249730-6	1997	In this study, we report the findings of immunohistochemical stains for TGF-beta, performed on paraffin sections of 14 human HCCs of the usual type and 11 examples of the fibrolamellar variant (FLC).	Paraffin	95-103	transforming growth factor beta 1	Homo sapiens	72-80
9205860-1	1997	We investigated the expression of androgen receptor (AR) protein in transitional cell carcinoma of human urinary bladder in paraffin-embedded sections of tumours obtained from nine patients with urinary bladder cancer treated by radical cystectomy.	Paraffin	124-132	androgen receptor	Homo sapiens	34-51
9205860-1	1997	We investigated the expression of androgen receptor (AR) protein in transitional cell carcinoma of human urinary bladder in paraffin-embedded sections of tumours obtained from nine patients with urinary bladder cancer treated by radical cystectomy.	Paraffin	124-132	androgen receptor	Homo sapiens	53-55
9205870-0	1997	Detectability of retinoblastoma (Rb) gene product and p53 antigen expression decreases in stored paraffin sections.	Paraffin	97-105	tumor protein p53	Homo sapiens	54-57
9467347-1	1997	OBJECTIVES: To evaluate the expression of E-cadherin, a calcium-dependent cell adhesion molecule, in a retrospective analysis of paraffin embedded tissue specimens of oral squamous cell carcinoma and relationship with the clinical TNM stage and histochemical differentiation.	Paraffin	129-137	cadherin 1	Homo sapiens	42-52
9108467-1	1997	The in vivo patterns of CPP32 (Caspase-3) gene expression were determined using an immunohistochemical approach and paraffin-embedded normal human tissues.	Paraffin	116-124	caspase 3	Homo sapiens	24-29
9108467-1	1997	The in vivo patterns of CPP32 (Caspase-3) gene expression were determined using an immunohistochemical approach and paraffin-embedded normal human tissues.	Paraffin	116-124	caspase 3	Homo sapiens	31-40
9110288-2	1997	O13, a monoclonal antibody that recognizes CD99, the p30/32MIC2 gene product, has been used to identify a number of cell types, including lymphoblasts, in paraffin sections.	Paraffin	155-163	CD99 molecule (Xg blood group)	Homo sapiens	43-47
12114668-5	1997	Immunohistochemical staining for p53 was performed on paraffin sections of formalin-fixed tumor tissue.	Paraffin	54-62	tumor protein p53	Homo sapiens	33-36
9215149-1	1997	AIM: To document the frequency and extent of p53 gene product expression in paraffin sections of resected non-small cell carcinoma of the lung and in cytological preparations of the same tumours; to determine the effect of microwave antigen retrieval on antigen detection.	Paraffin	76-84	tumor protein p53	Homo sapiens	45-48
9111231-5	1997	Specific LC1-ir was detected in ramified microglia of brains perfused with acidified aldehydes and embedded in paraffin.	Paraffin	111-119	annexin A1	Rattus norvegicus	9-12
9129144-5	1997	Positive staining of p53 protein was observed in three of the paraffin embedded tissues that were available: brain tumor, rhabdomyosarcoma, and lymphocytes from a normal lymph node from the rhabdomyosarcoma patient.	Paraffin	62-70	tumor protein p53	Homo sapiens	21-24
9098647-3	1997	To apply these molecular markers to commonly available archival material, we used reverse transcriptase-polymerase chain reaction and oligonucleotide hybridization methodology to develop an assay capable of identifying PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded tissue.	Paraffin	281-289	paired box 3	Homo sapiens	219-223
9136508-1	1997	Immunohistochemical analysis of the p53 protein was performed on paraffin sections of tumor tissue from 210 breast cancer patients.	Paraffin	65-73	tumor protein p53	Homo sapiens	36-39
9126051-3	1997	In this study, we have used an antibody against amyloid precursor protein, known to be a sensitive marker of axonal damage in a number of other contexts, in immunocytochemical experiments on paraffin embedded multiple sclerosis lesions of varying ages in order to see at which stage of the disease axonal damage, in addition to demyelination, occurs and may thus contribute to the development of disability in patients.	Paraffin	191-199	amyloid beta precursor protein	Homo sapiens	48-73
9076236-3	1997	DESIGN: We screened for p53 protein expression in a variety of benign epithelial lesions of upper respiratory tract using monoclonal antibody DO-1 on paraffin-embedded material.	Paraffin	150-158	tumor protein p53	Homo sapiens	24-27
9148861-2	1997	This study aimed to detect abnormalities in the gene structure, expression and localization of TGF-beta1, in paraffin-embedded samples from 31 ovarian neoplasias (21 malignant, 5 borderline and 5 benign).	Paraffin	109-117	transforming growth factor beta 1	Homo sapiens	95-104
21227061-3	1997	The purpose of this study was to assess the expression pattern of the CDKN2 protein product p 16 in a series of 104 prostatic adenocarcinomas treated by radical prostatectomy, using immunohistochemical detection on archival, paraffin-embedded material.	Paraffin	225-233	cyclin dependent kinase inhibitor 2A	Homo sapiens	70-75
9075790-1	1997	The relationship between p53 overexpression and clinicopathologic variables in gastric cancer was evaluated using 304 paraffin-embedded gastric tumor tissues.	Paraffin	118-126	tumor protein p53	Homo sapiens	25-28
9071734-0	1997	A rapid and nonisotopic method for the screening and sequencing of p53 gene mutations in formalin-fixed, paraffin-embedded tumors.	Paraffin	105-113	tumor protein p53	Homo sapiens	67-70
9071734-2	1997	In this study, we describe a sensitive, rapid, nonisotopic and inexpensive procedure for the polymerase chain reaction (PCR)-single-stranded conformational polymorphism (SSCP) detection and subsequent sequencing of p53 mutations in formalin-fixed and paraffin-embedded tumor (PET) samples.	Paraffin	251-259	tumor protein p53	Homo sapiens	215-218
21227061-3	1997	The purpose of this study was to assess the expression pattern of the CDKN2 protein product p 16 in a series of 104 prostatic adenocarcinomas treated by radical prostatectomy, using immunohistochemical detection on archival, paraffin-embedded material.	Paraffin	225-233	cyclin dependent kinase inhibitor 2A	Homo sapiens	92-96
8995554-6	1997	We conclude that PCR-TGGE is an appropriate method for detection of p53 point mutations in paraffin-embedded material.	Paraffin	91-99	tumor protein p53	Homo sapiens	68-71
10743081-2	1997	METHODS: Four-stage peroxidase antiperoxidase complex (PAP) method was applied to comparatively investigate the expression and distribution of Bcl-2 protein in formalin-fixed, paraffin-embedded lymph node tissue comprising 12 cases of reactive follicular hyperplasia and 71 cases of NHL.	Paraffin	176-184	BCL2 apoptosis regulator	Homo sapiens	143-148
9120731-7	1997	The ability of this method to detect 19 individual HLA DRB1 alleles or groups of alleles, covering all common DRB1 specificities, was confirmed via concordant results when compared with "direct" (single amplification step) PCR-SSP analysis of one cell line-derived and nine peripheral blood-derived DNA samples, and with five DNA samples extracted from paraffin biopsies.	Paraffin	353-361	major histocompatibility complex, class II, DR beta 1	Homo sapiens	51-59
9120731-7	1997	The ability of this method to detect 19 individual HLA DRB1 alleles or groups of alleles, covering all common DRB1 specificities, was confirmed via concordant results when compared with "direct" (single amplification step) PCR-SSP analysis of one cell line-derived and nine peripheral blood-derived DNA samples, and with five DNA samples extracted from paraffin biopsies.	Paraffin	353-361	major histocompatibility complex, class II, DR beta 1	Homo sapiens	55-59
8995081-9	1997	We concluded that the P53 and BCL2 expression detected by immunohistochemistry in routinely processed, paraffin-embedded tissues: (1) has no prognostic significance; and (2) was not correlated with pathologic disease stage, histologic grade, or vascular invasion.	Paraffin	103-111	BCL2 apoptosis regulator	Homo sapiens	30-34
8980360-3	1997	Genomic p53 was amplified with the polymerase chain reaction (PCR) from formalin-fixed, paraffin-embedded tissues.	Paraffin	88-96	tumor protein p53	Homo sapiens	8-11
9313826-2	1997	The p53 immunohistochemistry was performed on paraffin sections from 88 tumour samples.	Paraffin	46-54	tumor protein p53	Homo sapiens	4-7
9066684-2	1997	The study was performed on paraffin sections using the monoclonal antibodies DO7 and CBE1; the former recognizes both the wild-type and the mutant p53 forms, the latter recognizes the external domain of the transmembrane c-erbB-2 protein.	Paraffin	27-35	chromosome 9 open reading frame 24	Homo sapiens	85-89
9000604-1	1997	We could determine the S-phase fraction (SPF) by flow cytometric DNA analysis of paraffin archival material in 160 of 260 patients with soft-tissue sarcoma of extremity and trunk wall.	Paraffin	81-89	SEC14 like lipid binding 2	Homo sapiens	41-44
9033263-1	1997	High-resolution analyses of interleukin-6 mRNA in paraffin sections of lymph nodes.	Paraffin	50-58	interleukin 6	Homo sapiens	28-41
9058631-4	1997	METHODS: The p53 expression in tumour tissue was studied by immunohistochemistry using CM1 polyclonal rabbit antibody and formalin-fixed, paraffin-embedded material.	Paraffin	138-146	tumor protein p53	Homo sapiens	13-16
9083512-1	1997	We evaluated the expression of MDR1/p-glycoprotein in paediatric tumours using reverse transcriptase polymerase chain reaction (RT-PCR), RNA dot blot analysis, and immunohistochemistry on formalin fixed paraffin-embedded material with JSB-1 and C-219 monoclonal antibodies, and compared these three techniques.	Paraffin	203-211	ATP binding cassette subfamily B member 1	Homo sapiens	31-35
9032539-2	1997	MATERIALS AND METHODS: The p53 protein in the paraffin-embedded materials taken from 72 patients with RCCs was evaluated immunohistochemically and was compared with the histological findings, expression of proliferating cell nuclear antigen (PCNA), genetic instability as assessed by 2c deviation index (2cDI) and 5c exceeding rate (5cER) as well as clinical outcome.	Paraffin	46-54	tumor protein p53	Homo sapiens	27-30
8942496-3	1996	STUDY DESIGN: Immunohistochemical evaluation was used to examine p53 expression in paraffin blocks from 179 endometrial adenocarcinomas.	Paraffin	83-91	tumor protein p53	Homo sapiens	65-68
9868092-1	1997	Using polymerase chain reaction single strand conformational polymorphism (PCR-SSCP) and EB staining technique, paraffin-embeded sections of 20 hydatidiform mole and 4 choriocarcinoma were detected in the exons 5 and 8 of p53 gene.	Paraffin	112-120	tumor protein p53	Homo sapiens	222-225
10073037-0	1997	[Study of detecting p53 gene of laryngeal carcinoma on paraffin-embedded tissue sections by in situ polymerase chain reaction].	Paraffin	55-63	tumor protein p53	Homo sapiens	20-23
10073037-1	1997	In order to investigate alterations of p53 gene in laryngeal carcinoma, five cases of paraffin-embedded tissue were detected by in situ polymerase chain reaction (PCR).	Paraffin	86-94	tumor protein p53	Homo sapiens	39-42
9393591-3	1997	p53 nuclear accumulation was detected in 48% of the primary tumours using the PAb1801 antibody in archival paraffin-embedded tissue sections.	Paraffin	107-115	tumor protein p53	Homo sapiens	0-3
9521509-1	1997	The immunohistological expression of p53 and MDM2 oncoproteins was examined in paraffin embedded tissue from 106 patients with transitional cell carcinoma of the urinary bladder and was related to various clinicopathological features, the expression of proliferation associated markers (proliferating cell nuclear antigen - PCNA - and Ki-67), c-erb B-2 oncoprotein and epidermal growth factor receptor (EGFR), as well as to survival.	Paraffin	79-87	tumor protein p53	Homo sapiens	37-40
9337544-7	1997	Paraffin sections of tumours were stained immunohistochemically by antibody against endothelial marker CD34.	Paraffin	0-8	CD34 molecule	Homo sapiens	103-107
11091754-2	1996	The bcl-2 protein was detected by immunohistochemistry on paraffin embedded tissue sections and its presence was confirmed by Western blot analysis of whole cell lysates.	Paraffin	58-66	BCL2 apoptosis regulator	Homo sapiens	4-9
9031911-3	1996	AR immunocytochemistry was performed on 30 paraffin-embedded uterine sections of pre-menopausal women who were scheduled for hysterectomy because of benign gynaecologic abnormalities.	Paraffin	43-51	androgen receptor	Homo sapiens	0-2
8958295-2	1996	Both antibodies are able to detect pS2 in formalin-fixed, paraffin-embedded tissues.	Paraffin	58-66	trefoil factor 1	Homo sapiens	35-38
9222302-4	1997	Expression of P-gp was immunohistochemically studied by using two monoclonal antibodies, JSB-1 and C-219, on paraffin-embedded sections from 55 patients with soft-tissue sarcoma.	Paraffin	109-117	ATP binding cassette subfamily B member 1	Homo sapiens	14-18
9260591-4	1997	The expression of the proteins p53 and mdm2 was determined immunohistochemically using formalin-fixed, paraffin-embedded material.	Paraffin	103-111	tumor protein p53	Homo sapiens	31-34
9059354-1	1997	AIMS: To investigate wet heat pretreatment (pressure cooking) as a means of antigen retrieval for demonstration of MyoD1 in paraffin wax embedded tissue.	Paraffin	124-136	myogenic differentiation 1	Homo sapiens	115-120
9342752-6	1997	Our results indicate that IHC could be applied for studies of p53 protein accumulation in archival formalin fixed, paraffin-embedded bladder tumours.	Paraffin	115-123	tumor protein p53	Homo sapiens	62-65
8955620-0	1996	Detection of p53 gene abnormality by sequence analysis of archival paraffin tissue.	Paraffin	67-75	tumor protein p53	Homo sapiens	13-16
8942499-3	1996	Overexpression of p53 protein was determined with the use of immunohistochemistry on fixed and paraffin-embedded tissue.	Paraffin	95-103	tumor protein p53	Homo sapiens	18-21
8813082-2	1996	In this study we demonstrate the potential use of NeuN as a diagnostic neuronal marker using a wide range of formalin-fixed, paraffin-embedded human surgical and autopsy specimens from the central and peripheral nervous system.	Paraffin	125-133	RNA binding fox-1 homolog 3	Homo sapiens	50-54
8994354-3	1996	In the present study, we examined the expression of VEGF in the paraffin sections of 20 eyes harboring retinoblastoma or posterior uveal melanoma, but also in corresponding tumor cellines.	Paraffin	64-72	vascular endothelial growth factor A	Homo sapiens	52-56
8997010-1	1996	Using a polyclonal antibody against the c-erbB-2 gene product, an immunohistochemical study on the expression of c-erbB-2 oncoprotein was performed in routine formalin-fixed, paraffin-embedded tissue sections from 119 patients with primary breast cancer.	Paraffin	175-183	erb-b2 receptor tyrosine kinase 2	Homo sapiens	113-121
8918900-1	1996	The relationship between expression of the c-erbB-2 proto-oncogene and the biology of breast cancer has been investigated widely, most studies using immunohistochemistry in formalin-fixed, paraffin-embedded tissues.	Paraffin	189-197	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-51
9387524-2	1996	METHODS: The amplification and expression of c-erbB2 oncogene were determined from formalin-fixed, paraffin-embedded tissues of 25 normal, 31 hyperplastic, and 72 malignant samples of the endometrium in 128 patients, using differential polymerase chain reaction (DPCR) and an immunohistochemical technique.	Paraffin	99-107	erb-b2 receptor tyrosine kinase 2	Homo sapiens	45-52
8863659-3	1996	To evaluate expression of the CD79 alpha antigen in acute myeloid leukemia (AML), we studied forty-eight cases of AML by paraffin section immunohistochemistry.	Paraffin	121-129	CD79a molecule	Homo sapiens	30-40
8813082-10	1996	The results indicate that NeuN immunoreactivity is a sensitive and specific neuronal marker in formalin-fixed, paraffin-embedded tissues, and may be useful in diagnostic histopathology.	Paraffin	111-119	RNA binding fox-1 homolog 3	Homo sapiens	26-30
8957065-3	1996	Moreover, c-met protein was demonstrated in 34 (72.3%) of 47 surgically resected adenocarcinomas, 20 (38.5%) of 52 squamous cell carcinomas and 3 of 5 others, and the results were mostly confirmed immunohistochemically in formalin-fixed and paraffin-embedded tumors of the same case.	Paraffin	241-249	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	10-15
8808919-3	1996	MATERIALS AND METHODS: The expression of p53 and bcl-2 was evaluated in archival paraffin-embedded RP specimens from 175 patients followed from 1 to 9 years (mean = 4.6 years) and correlated with stage, grade, race and serologic (PSA) recurrence following surgery.	Paraffin	81-89	tumor protein p53	Homo sapiens	41-44
8938590-3	1996	Hybridisation histochemistry was used to detect transcription of PTHrP and PTH in serial paraffin sections through the 12.5- and 13.5-day rat embryo parathyroid anlage, as well as in sections through the 17.5-day embryonic and adult parathyroid glands.	Paraffin	89-97	parathyroid hormone	Rattus norvegicus	65-68
8816590-3	1996	The authors determined the ER status of 103 invasive breast cancers by paraffin-based, automated immunohistochemistry on the Ventana ES using a new monoclonal antibody, CC4-5, and compared the results to those of parallel DCC biochemical analysis and manual immunohistochemical analysis using anti-ER monoclonal antibody ER1D5.	Paraffin	71-79	estrogen receptor 1	Homo sapiens	27-29
8958547-1	1996	A new monoclonal antibody against estrogen receptor (ID5, Dako) has shown promising results when applied to formalin fixed, paraffin embedded tissue.	Paraffin	124-132	estrogen receptor 1	Homo sapiens	34-51
8816590-2	1996	Recent second generation anti-ER antibodies and new epitope retrieval methods have produced paraffin-based immunohistochemical results that correlate closely with the dextran-coated charcoal (DCC) assay and appear to represent a superior method of ER assay.	Paraffin	92-100	estrogen receptor 1	Homo sapiens	30-32
8917409-0	1996	Effect of microwave oven heating times on androgen receptor antigen retrieval from paraffin-embedded prostatic adenocarcinoma.	Paraffin	83-91	androgen receptor	Homo sapiens	42-59
9387269-1	1996	Paraffin-embedded hepatocellular carcinoma (HCC) samples were used to study point mutation of p53 gene at 249 codon in the exon 7 by polymerase chain reaction and gel electrophoresis under Hae III enzyme digestion.	Paraffin	0-8	tumor protein p53	Homo sapiens	94-97
8816885-0	1996	Immunohistochemical detection of p21waf1/cip1/sdi1 and p53 proteins in formalin-fixed, paraffin-embedded tissue sections of colorectal carcinoma.	Paraffin	87-95	cyclin dependent kinase inhibitor 1A	Homo sapiens	33-45
9009679-3	1996	Paraffin fixed specimens of benign and malignant neoplasia, occurring in patients with NF1 and NF2, were tested for the presence of p53: a reliable marker of genetic oncosupression.	Paraffin	0-8	neurofibromin 1	Homo sapiens	87-90
8797881-3	1996	We analyzed BSP expression in 454 breast-cancer patients by immunohistochemistry on archival paraffin-embedded material using an anti-BSP polyclonal antibody.	Paraffin	93-101	integrin binding sialoprotein	Homo sapiens	12-15
8761369-0	1996	TP53 mutation analyses on breast carcinomas: a study of paraffin-embedded archival material.	Paraffin	56-64	tumor protein p53	Homo sapiens	0-4
8879300-2	1996	The accumulation of p53 protein was studied immunohistochemically using monoclonal antibody BP53-12 on formalin-fixed paraffin-embedded sections of 36 KS lesions, of which 14 were classified histologically as early type and 22 as spindle-cell or mixed type.	Paraffin	118-126	tumor protein p53	Homo sapiens	20-23
8683636-1	1996	BACKGROUND: We previously observed decreased p53 immunostaining over time in paraffin-embedded sections of ductal carcinoma in situ of the breast of women; these sections had been stored on slides at room temperature.	Paraffin	77-85	tumor protein p53	Homo sapiens	45-48
8761369-1	1996	The aim of this investigation was to examine the possibility of analysing TP53 mutations in archival paraffin-embedded material with the constant denaturant gel electrophoresis (CDGE) method.	Paraffin	101-109	tumor protein p53	Homo sapiens	74-78
8881915-2	1996	METHODS: Expression of p53 was evaluated immunocytochemically in a retrospective study of formalin fixed, paraffin wax embedded tissue.	Paraffin	106-118	tumor protein p53	Homo sapiens	23-26
8758921-4	1996	Of the 17 anti-CD43 mAbs used, 9 reacted with leukocytes in paraffin-fixed formalin-embedded lymph node tissues.	Paraffin	60-68	sialophorin	Homo sapiens	15-19
8912347-3	1996	In this study we examined both benign and borderline malignant/malignant mucinous neoplasms for p53 protein accumulation by the means of an anti-human p53 protein monoclonal antibody on paraffin sections.	Paraffin	186-194	tumor protein p53	Homo sapiens	96-99
8797205-1	1996	Evaluation of the p53 gene protein expression and proliferative potential with MIB-1 monoclonal antibody (MBL Co.), a new marker of cellular proliferation that binds Ki67 in paraffin sections, by immunohistochemical studies were made in 10 cases of the non-recurrent meningiomas and the 8 cases (17 samples) of the recurrent meningiomas.	Paraffin	174-182	tumor protein p53	Homo sapiens	18-21
8666362-4	1996	Paraffin-embedded tissue sections were immunostained with monoclonal antibody to p53 and MDM2 proteins.	Paraffin	0-8	tumor protein p53	Homo sapiens	81-84
8663952-2	1996	OBJECTIVE: To demonstrate how the detection of p53 protein in formaldehyde-fixed, paraffin-embedded oropharyngeal carcinoma may be used as a factor in estimating prognosis.	Paraffin	82-90	tumor protein p53	Homo sapiens	47-50
8679463-2	1996	Expression of Bcl-2 was determined using immunohistochemistry on paraffin-embedded sections in a series of 441 premenopausal, lymph node-negative breast cancers of patients randomised to receive perioperative chemotherapy (5-fluorouracil, doxorubicin, cyclophosphamide) or no perioperative chemotherapy.	Paraffin	65-73	BCL2 apoptosis regulator	Homo sapiens	14-19
12114639-0	1996	Possible Relation of p53 and mdm-2 Oncoprotein Expression in Thyroid Carcinoma: A Molecular-Pathological and Immunohistochemical Study on Paraffin-Embedded Tissue.	Paraffin	138-146	tumor protein p53	Homo sapiens	21-24
8818693-2	1996	To investigate whether overexpressed bcl-2 and abnormally stabilized p53 are associated with reduced apoptosis in paraffin sections of non-small cell lung carcinoma, apoptotic, mitotic, and Ki-67 labelling indices were determined and correlated with bcl-2 and p53 immunoreactivity in 54 squamous cell carcinomas and 22 adenocarcinomas.	Paraffin	114-122	BCL2 apoptosis regulator	Homo sapiens	37-42
8818693-2	1996	To investigate whether overexpressed bcl-2 and abnormally stabilized p53 are associated with reduced apoptosis in paraffin sections of non-small cell lung carcinoma, apoptotic, mitotic, and Ki-67 labelling indices were determined and correlated with bcl-2 and p53 immunoreactivity in 54 squamous cell carcinomas and 22 adenocarcinomas.	Paraffin	114-122	tumor protein p53	Homo sapiens	69-72
8843456-4	1996	Immunohistochemical localization of transforming growth factor-alpha in archival paraffin-embedded sections was performed with commercially available monoclonal antibodies.	Paraffin	81-89	tumor necrosis factor	Homo sapiens	36-68
8640687-0	1996	Paraffin section immunocytochemistry for estrogen receptor: the time has come.	Paraffin	0-8	estrogen receptor 1	Homo sapiens	41-58
8640700-0	1996	Estrogen receptor immunocytochemistry in paraffin embedded tissues with ER1D5 predicts breast cancer endocrine response more accurately than H222Sp gamma in frozen sections or cytosol-based ligand-binding assays.	Paraffin	41-49	estrogen receptor 1	Homo sapiens	0-17
8640700-3	1996	Lately, new monoclonal antibodies derived by recombinant ER technology have been developed that work well on paraffin embedded, formalin fixed tissue sections.	Paraffin	109-117	estrogen receptor 1	Homo sapiens	57-59
8640700-6	1996	RESULTS: ER1D5 in paraffin provided the highest correlation with endocrine response (Kendall"s tau [r] = 0.57; P&lt;0.001) whereas ER by DCC failed to correlate (r= -0.002; P&lt;0.99).	Paraffin	18-26	estrogen receptor 1	Homo sapiens	9-11
8635161-4	1996	In the present study, somatic alterations of p16/MTS1 were examined concentrating on histologically defined superficial bladder carcinomas by polymerase chain reaction (PCR)-single strand conformation polymorphism (SSCP) technique using paraffin embedded materials.	Paraffin	237-245	cyclin dependent kinase inhibitor 2A	Homo sapiens	45-48
8831062-5	1996	The expression of the c-erbB-2 protein was evaluated by immunohistochemical staining of the gene product with the avidin-biotin-complex method using paraffin-embedded tissues sections.	Paraffin	149-157	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-30
8840159-5	1996	Staining of paraffin sections of Merkel cell carcinomas with an anti-bcl-2 monoclonal antibody revealed strong bcl-2 protein immunoreactivity in all 5 tumors tested.	Paraffin	12-20	BCL2 apoptosis regulator	Homo sapiens	69-74
8840159-5	1996	Staining of paraffin sections of Merkel cell carcinomas with an anti-bcl-2 monoclonal antibody revealed strong bcl-2 protein immunoreactivity in all 5 tumors tested.	Paraffin	12-20	BCL2 apoptosis regulator	Homo sapiens	111-116
8816839-4	1996	Protein p53 expression was evaluated by immunohistochemistry using Pab 1801, Pab 240, DO7 and CM1 antibodies on paraffin-embedded sections.	Paraffin	112-120	tumor protein p53	Homo sapiens	8-11
8683246-3	1996	bcl2 and p53 protein expression was studied on paraffin-embedded tumor tissue by immunohistochemistry in relation to clinical factors.	Paraffin	47-55	tumor protein p53	Homo sapiens	9-12
8675997-0	1996	Immunohistochemical detection of thrombospondin-1 in formalin-fixed, paraffin-embedded tissue.	Paraffin	69-77	thrombospondin 1	Homo sapiens	33-49
8675997-5	1996	Our objective in this study was to determine the optimal antigen retrieval (AR) protocol for detection of TSP in formalin-fixed, paraffin-embedded tissue by using tissue sections from patients with invasive transitional cell carcinoma of the bladder.	Paraffin	129-137	thrombospondin 1	Homo sapiens	106-109
8675997-7	1996	Our results demonstrate that TSP can be reliably detected in paraffin-embedded tissue by immunohistochemical techniques that utilize AR with high-temperature microwave heating and a low-pH Tris-HCI buffer.	Paraffin	61-69	thrombospondin 1	Homo sapiens	29-32
21594450-2	1996	In this retrospective study the pS2 protein expression was detected by immunohistochemistry in formalin-fixed, paraffin-embedded breast cancer sections from 219 patients with primary breast cancer.	Paraffin	111-119	taste 2 receptor member 64 pseudogene	Homo sapiens	32-35
8818255-2	1996	This is a longitudinal study of p53 expression in fixed, paraffin-embedded tissue from 3 patients with multiple, recurrent, squamous cell carcinomas of floor of mouth (n = 4, 4, 3).	Paraffin	57-65	tumor protein p53	Homo sapiens	32-35
16696068-0	1996	Nested PCR-SSCP assay for the detection of p53 mutations in paraffin wax embedded bone tumours: improvement of sensitivity and fidelity.	Paraffin	60-72	tumor protein p53	Homo sapiens	43-46
8671959-5	1996	The immunohistochemical strept.ABC method was performed on paraffin sections for the detection of bcl-2 protein with a monoclonal antibody after microwave pretreatment.	Paraffin	59-67	BCL2 apoptosis regulator	Homo sapiens	98-103
8766529-1	1996	We investigated immunohistochemical localization of P-glycoprotein (P-gp) on paraffin-embedded sections from 103 cases of previously untreated pancreatic tumors and also analyzed multidrug resistance-1 (MDR1) gene expression by polymerase chain reaction after reverse transcription in 35 cases.	Paraffin	77-85	ATP binding cassette subfamily B member 1	Homo sapiens	52-66
8766529-1	1996	We investigated immunohistochemical localization of P-glycoprotein (P-gp) on paraffin-embedded sections from 103 cases of previously untreated pancreatic tumors and also analyzed multidrug resistance-1 (MDR1) gene expression by polymerase chain reaction after reverse transcription in 35 cases.	Paraffin	77-85	ATP binding cassette subfamily B member 1	Homo sapiens	68-72
10330207-3	1996	Mutational analysis of p53 was performed retrospectively by means of topographic genotyping (TG), using formalin-fixed, paraffin-embedded tissue of the primary and recurrent tumor.	Paraffin	120-128	tumor protein p53	Homo sapiens	23-26
8782209-10	1996	We used the DO-7 monoclonal antibody reactive for the N-terminal of the p53 protein on formalin-fixed paraffin-embedded tissue.	Paraffin	102-110	tumor protein p53	Homo sapiens	72-75
8623909-5	1996	Our purpose was to investigate the possibility that E-cadherin could be demonstrated in paraffin-embedded whole prostates and metastatic prostate cancer.	Paraffin	88-96	cadherin 1	Homo sapiens	52-62
8688970-3	1996	The expression of cyclin D3 was studied immunohistochemically in archival formalin-fixed, paraffin-embedded specimens from normal organs obtained from three autopsy cases and 237 human primary pulmonary carcinomas.	Paraffin	90-98	cyclin D3	Homo sapiens	18-27
8761996-1	1996	Expression of beta-trace protein (beta-trace), recently identified as glutathion-independent prostaglandin D synthase (prostaglandin-H2 D-isomerase; EC 5.3.99.2), was localized in paraffin sections of the human brain by in situ hybridization using digoxigenin-labeled antisense cRNA probes.	Paraffin	180-188	prostaglandin D2 synthase	Homo sapiens	14-32
8761996-1	1996	Expression of beta-trace protein (beta-trace), recently identified as glutathion-independent prostaglandin D synthase (prostaglandin-H2 D-isomerase; EC 5.3.99.2), was localized in paraffin sections of the human brain by in situ hybridization using digoxigenin-labeled antisense cRNA probes.	Paraffin	180-188	prostaglandin D2 synthase	Homo sapiens	93-117
8761996-1	1996	Expression of beta-trace protein (beta-trace), recently identified as glutathion-independent prostaglandin D synthase (prostaglandin-H2 D-isomerase; EC 5.3.99.2), was localized in paraffin sections of the human brain by in situ hybridization using digoxigenin-labeled antisense cRNA probes.	Paraffin	180-188	prostaglandin D2 synthase	Homo sapiens	119-147
8640663-3	1996	METHODS: The expression of p53 was studied immunohistochemically in 200 gastric carcinomas using paraffin embedded surgical specimens and endoscopic biopsies.	Paraffin	97-105	tumor protein p53	Homo sapiens	27-30
8623909-6	1996	Microwaving in citrate buffer was the best of five methods tested for the demonstration of E-cadherin in paraffin-embedded prostate and was used to investigate 53 primary prostate cancers from 44 patients and lymph node metastases from 14 patients.	Paraffin	105-113	cadherin 1	Homo sapiens	91-101
8623909-9	1996	The use of monoclonal anti-human E-cadherin (HECD-1) with microwaving in citrate buffer followed by immunoperoxidase staining with heavy metal enhancement for the demonstration of E-cadherin in paraffin-embedded tissue will, for the first time, allow the use of archival tissue for prognostic studies of E-cadherin in prostate cancer and other tissue.	Paraffin	194-202	cadherin 1	Homo sapiens	180-190
8623909-9	1996	The use of monoclonal anti-human E-cadherin (HECD-1) with microwaving in citrate buffer followed by immunoperoxidase staining with heavy metal enhancement for the demonstration of E-cadherin in paraffin-embedded tissue will, for the first time, allow the use of archival tissue for prognostic studies of E-cadherin in prostate cancer and other tissue.	Paraffin	194-202	cadherin 1	Homo sapiens	180-190
8623923-10	1996	Labeling of paraffin sections with PG-B6p proved useful for differentiating proliferation centers in B-CLL (BCl-2+/BCL-6-) from trapped germinal centers in mantle cell lymphomas (BCL-2-/BCL-6+) and for identifying neoplastic cells in cases of nodular, lymphocyte-predominance Hodgkin"s disease.	Paraffin	12-20	BCL2 apoptosis regulator	Homo sapiens	108-113
8767868-3	1996	Expression of p53 protein was examined by immunohistochemistry in paraffin-embedded sections.	Paraffin	66-74	tumor protein p53	Homo sapiens	14-17
8623923-10	1996	Labeling of paraffin sections with PG-B6p proved useful for differentiating proliferation centers in B-CLL (BCl-2+/BCL-6-) from trapped germinal centers in mantle cell lymphomas (BCL-2-/BCL-6+) and for identifying neoplastic cells in cases of nodular, lymphocyte-predominance Hodgkin"s disease.	Paraffin	12-20	BCL2 apoptosis regulator	Homo sapiens	179-184
8643220-1	1996	An immunohistochemical stain to the c-ErbB-2 protein was performed in 225 paraffin-embedded tissue blocks from patients with locally advanced gastric cancer who underwent curative resection.	Paraffin	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-44
8781989-0	1996	Retrieval of estradiol receptor in paraffin sections of resting porcine uteri by microwave treatment.	Paraffin	35-43	estrogen receptor 1	Homo sapiens	13-31
8835823-1	1996	The expression of p53 protein was studied in odontogenic keratocysts (OKC, 11 solitary, 5 recurrent and 6 NBCCS cysts), radicular (RC, n = 5) and dentigerous (DC, n = 5) cysts, using a panel of antibodies to p53 (clone BP53-12, clone 1801 and polyclonal CM1) and a sensitive biotin-streptavidin method on paraffin embedded sections.	Paraffin	305-313	tumor protein p53	Homo sapiens	18-21
8733771-4	1996	The bcl-2 protein was detected after antigen retrieval with bcl-2 monoclonal antibody using archival formalin-fixed, paraffin-embedded tissue material.	Paraffin	117-125	BCL2 apoptosis regulator	Homo sapiens	4-9
8641546-1	1996	We examined the expression of E-cadherin and collagenase type IV in formalin-fixed, paraffin-embedded specimens of human gastric carcinoma by an in situ mRNA hybridization (ISH) technique.	Paraffin	84-92	cadherin 1	Homo sapiens	30-40
8780936-2	1996	Paraffin-embedded tissues of 46 bone marrow biopsies were stained with a monoclonal antibody to bcl-2 protein using the supersensitive streptavidin biotin immunoperoxidase method after a microwave heating of the sections.	Paraffin	0-8	BCL2 apoptosis regulator	Homo sapiens	96-101
8734653-3	1996	METHODS: We attempted to retrieve the trichohyalin antigenicity in formalin-fixed, paraffin-embedded biopsy specimens that included normal skin as well as skin tumors such as trichofolliculoma and pilotricoma.	Paraffin	83-91	trichohyalin	Homo sapiens	38-50
8606380-5	1996	METHODS: Immunohistochemical analysis with a monoclonal antibody (DO7) specific for p53 protein was used to detect expression of the protein in formalin-fixed, paraffin-embedded tumor samples from 69 head and neck cancer patients treated with definitive local therapy (surgery and/or radiotherapy) between January 1980 and October 1983 at The University of Texas M. D. Anderson Cancer Center.	Paraffin	160-168	tumor protein p53	Homo sapiens	84-87
8644851-3	1996	DNA isolated from paraffin-embedded specimens was subjected to polymerase chain reaction amplification for a highly polymorphic region of the human androgen receptor gene (HUMARA).	Paraffin	18-26	androgen receptor	Homo sapiens	148-165
8670040-5	1996	The expression of the c-erbB-2 protein was evaluated by immunohistochemical staining of the gene product with the avidin-biotin-complex method using both fresh frozen and paraffin-embedded tissue sections.	Paraffin	171-179	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-30
8611406-2	1996	Expression of P53 protein was detected by an immunohistochemical approach using the monoclonal antibody PAb1801 on paraffin-embedded sections of tumours obtained surgically from 102 stage II - IIIa patients with non-small-cell lung cancer (52 squamous cell carcinomas, 50 adenocarcinomas).	Paraffin	115-123	tumor protein p53	Homo sapiens	14-17
8695259-1	1996	The expression of mutated p53 protein was studied in paraffin-embedded, formalin-fixed tumour specimens from 183 women with endometrial carcinoma.	Paraffin	53-61	tumor protein p53	Homo sapiens	26-29
8734919-5	1996	Staining of paraffin sections of Merkel cell carcinomas with an anti-bcl-2 monoclonal antibody revealed strong bcl-2 protein immunoreactivity in all 5 tumors tested.	Paraffin	12-20	BCL2 apoptosis regulator	Homo sapiens	69-74
8734919-5	1996	Staining of paraffin sections of Merkel cell carcinomas with an anti-bcl-2 monoclonal antibody revealed strong bcl-2 protein immunoreactivity in all 5 tumors tested.	Paraffin	12-20	BCL2 apoptosis regulator	Homo sapiens	111-116
8608838-9	1996	p53 protein overexpression was determined immunohistochemically from paraffin sections of the original primary tumour and resected metastases.	Paraffin	69-77	tumor protein p53	Homo sapiens	0-3
8626117-5	1996	Immunohistochemical staining for the p53 protein with monoclonal antibody PAb 1801 was performed in the paraffin-embedded tissue of each case to screen for p53 overexpression.	Paraffin	104-112	tumor protein p53	Homo sapiens	37-40
8732185-2	1996	Using immunoperoxidase staining on paraffin sections, the immunohistochemical results show that CD34 antigen is expressed widely on human CNS endothelium in grey and white matter, in the eye including retina, and in the anterior and posterior lobes of the pituitary.	Paraffin	35-43	CD34 molecule	Homo sapiens	96-100
8691320-1	1996	To examine the expression of p53 protein and gene alterations in oral epithelial lesions including epithelial dysplasias and primary squamous cell carcinomas, immunohistochemical and temperature gradient gel electrophoresis (TGGE) methods were applied to formalin-fixed and paraffin-embedded tissues.	Paraffin	274-282	tumor protein p53	Homo sapiens	29-32
9388844-2	1996	METHOD: Using a rabbit polyclonal antibody against P16 (N-20), the expression of P16 protein was studied immunohistochemically on formalin fixed, paraffin embedded sections.	Paraffin	146-154	cyclin dependent kinase inhibitor 2A	Homo sapiens	81-84
8758275-2	1996	METHODS: Expression of EGFR oncoprotein was studied by immunohistochemistry in paraffin-embedded tumor tissues from 28 patients with endometrioid carcinoma of the ovary.	Paraffin	79-87	epidermal growth factor receptor	Homo sapiens	23-27
8711933-3	1996	In this study, we investigated the immunohistochemical expression of p53 in formalin fixed paraffin embedded archival specimens of 36 extrahepatic bile duct cancers in which p53 expression was found in eighteen (50%) cases.	Paraffin	91-99	tumor protein p53	Homo sapiens	69-72
8593669-1	1996	The expression of the 3-fucosyl-N-acetyl-lactosamine (CD15) epitope during the embryonic development of the mouse inner ear has been immunohistochemically studied on paraffin sections from day 8.5 to day 19 of gestation.	Paraffin	166-174	fucosyltransferase 4	Mus musculus	54-58
8608964-1	1996	Optimal conditions for immunohistochemical staining of tumor necrosis factor-alpha (TNF-alpha) in paraffin-embedded tissue sections were established to investigate TNF-alpha expression in human primary malignant melanomas.	Paraffin	98-106	tumor necrosis factor	Homo sapiens	55-82
8608964-1	1996	Optimal conditions for immunohistochemical staining of tumor necrosis factor-alpha (TNF-alpha) in paraffin-embedded tissue sections were established to investigate TNF-alpha expression in human primary malignant melanomas.	Paraffin	98-106	tumor necrosis factor	Homo sapiens	84-93
8598230-5	1996	The expression of CD34 was analyzed with FC on fresh bone marrow cells and with IH on sections of paraffin-embedded bone marrow.	Paraffin	98-106	CD34 molecule	Homo sapiens	18-22
8695923-7	1996	Immunohistochemistry was performed with an anti-bcl-2 monoclonal antibody on paraffin sections.	Paraffin	77-85	BCL2 apoptosis regulator	Homo sapiens	48-53
8925599-3	1996	We used a set of 6 different antibodies against p53, suitable for paraffin section (PAb1801, PAb240, DO-1, DO-7, BP53-12, CM-1).	Paraffin	66-74	tumor protein p53	Homo sapiens	48-51
8964169-6	1996	Twenty-six (48%) smears and 23 (43%) matched paraffin sections gave specific signal for c-erbB-2 oncoprotein.	Paraffin	45-53	erb-b2 receptor tyrosine kinase 2	Homo sapiens	88-96
8964169-1	1996	Most of the data regarding the significance of c-erbB-2 oncogene expression as a prognostic marker in breast cancer have been generated in many large retrospective studies by retrieving the corresponding oncoprotein in archival paraffin embedded sections.	Paraffin	228-236	erb-b2 receptor tyrosine kinase 2	Homo sapiens	47-55
9816168-5	1996	The expression of bcl-2 was analyzed by immunohistochemistry on paraffin-embedded sections from 71 consecutive stage I-II SCCHN patients treated with curative RT.	Paraffin	64-72	BCL2 apoptosis regulator	Homo sapiens	18-23
8598357-2	1996	METHODS AND MATERIALS: Epidermal growth factor receptor protein expression was investigated immunohistochemically in formalin-fixed, paraffin-embedded surgical specimens of 55 glioblastoma multiforme, 14 anaplastic astrocytoma, and 2 astrocytomas given definitive irradiation.	Paraffin	133-141	epidermal growth factor receptor	Homo sapiens	23-55
8600035-1	1996	The immunohistochemical expression of bcl-2 and p53 proteins was evaluated in formalin-fixed, paraffin-embedded surgical specimens from 212 patients with primary gastric lymphoma.	Paraffin	94-102	BCL2 apoptosis regulator	Homo sapiens	38-43
8600043-4	1996	Ki67 (MIB-1) and p53 monoclonal antibodies (active on paraffin embedded tissues) provide insight into nuclear proliferation and control, respectively.	Paraffin	54-62	tumor protein p53	Homo sapiens	17-20
8778328-2	1996	This immunohistochemical study on formalin-fixed, paraffin-embedded material found p53 expression in 43 per cent (n = 51) of carcinomas using a monoclonal antibody (DO-1), whereas no immunoreactivity for p53 was present in tumour-associated non-neoplastic gastric mucosa or tumour stroma.	Paraffin	50-58	tumor protein p53	Homo sapiens	83-86
8608381-6	1996	RESULTS: Microscopic examination of paraffin-embedded sections showed CD34-negative DFSP tumor cells with positive staining of endothelial cells.	Paraffin	36-44	CD34 molecule	Homo sapiens	70-74
8920221-0	1996	Immunohistochemical detection of P53 overexpression in paraffin wax-embedded squamous cell carcinomas of cattle, horses, cats and dogs.	Paraffin	55-67	tumor protein p53	Homo sapiens	33-36
8801209-5	1996	The expression of p53 protein was detected immunohistochemically in paraffin wax embedded liver specimens, after microwave pretreatment.	Paraffin	68-80	tumor protein p53	Homo sapiens	18-21
8920221-7	1996	Thus p53 antigen could be detected immunohistochemically in formalin-fixed and paraffin wax-embedded tissues of SCCs of domestic animals.	Paraffin	79-91	tumor protein p53	Equus caballus	5-8
8625227-12	1996	Paraffin-section immunostaining showed positive reactions for epithelial membrane antigen (100%), keratin (AE1/AE3) (88%), alpha-lactalbumin (88%), GCDFP-15 (76%), and carcinoembryonic antigen (72%); S-100 protein was rarely detected (4%).	Paraffin	0-8	lactalbumin alpha	Homo sapiens	123-140
8625227-12	1996	Paraffin-section immunostaining showed positive reactions for epithelial membrane antigen (100%), keratin (AE1/AE3) (88%), alpha-lactalbumin (88%), GCDFP-15 (76%), and carcinoembryonic antigen (72%); S-100 protein was rarely detected (4%).	Paraffin	0-8	prolactin induced protein	Homo sapiens	148-156
8821949-3	1996	Within a defined population between 1947 and 1994, we found 12 cases of primary sinonasal T-cell lymphoma, all with a CD20-, CD3+ immunophenotype in paraffin sections.	Paraffin	149-157	keratin 20	Homo sapiens	118-122
8619936-2	1996	This antibody was used in an immunohistochemical procedure to detect the c-erbB-2 protein on a series of 88 paraffin-embedded human breast carcinomas.	Paraffin	108-116	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-81
9431695-0	1996	Immunoreactivity of new antibodies anti-p53 and anti-MDM-2 in paraffin embedded tissue samples.	Paraffin	62-70	tumor protein p53	Homo sapiens	40-43
9431695-1	1996	Detection of various epitopes of the p53 and MDM-2 proteins, using new antibodies was performed on formalin-fixed and paraffin-embedded tissue samples from breast cancer and compared with results obtained using well-characterized antibodies.	Paraffin	118-126	tumor protein p53	Homo sapiens	37-40
8554449-4	1996	DESIGN: Anti-human Pit-1 polyclonal antibody against synthetic peptide was applied to perform the avidin-biotinperoxidase complex method on paraffin sections of 75 surgically obtained pituitary adenomas and 12 nontumorous human pituitaries obtained at autopsy.	Paraffin	140-148	POU class 1 homeobox 1	Homo sapiens	19-24
8871764-2	1996	We describe the immunohistochemical detection of tumor necrosis factor-alpha using formaldehyde fixed and paraffin embedded tissue and a polyclonal anti-serum with high tumor necrosis factor-alpha neutralising activity.	Paraffin	106-114	tumor necrosis factor	Homo sapiens	49-76
8547651-13	1996	Thus bcl-2 protein expression, as demonstrated in routinely paraffin-embedded tissue, appears to be predictive of poor DFS, in agreement with the role of bcl-2 in chemotherapy-induced apoptosis.	Paraffin	60-68	BCL2 apoptosis regulator	Homo sapiens	5-10
8704095-2	1996	We examined paraffin sections for the expression of interleukin-1 alpha, interleukin-1 beta and tumor necrosis factor-alpha, in 40 cases of Hodgkin"s disease.	Paraffin	12-20	interleukin 1 beta	Homo sapiens	73-123
8954175-1	1996	The polymerase chain reaction and HaeIII enzymatic digestion were used to study the seventh exon of the p53 gene in 29 primary and recurrent hepatomas in paraffin-embedded samples from 11 patients.	Paraffin	154-162	tumor protein p53	Homo sapiens	104-107
8832944-4	1996	OBJECTIVE AND METHODS: The aim of the present study is to examine the frequency of immunohistochemically detectable p53 protein by using two monoclonal antibodies (D07 and BP53-12) in 8 cases of formalin-fixed and paraffin-embedded specimens of verrucous skin carcinoma.	Paraffin	214-222	tumor protein p53	Homo sapiens	116-119
8685041-2	1996	Expression of bcl-2 protein was analyzed in 54 cases of primary non-Hodgkin"s malignant lymphomas of the oral cavity by immunohistologic staining of paraffin-embedded tissue.	Paraffin	149-157	BCL2 apoptosis regulator	Homo sapiens	14-19
8570124-1	1996	The expression of pS2 estrogen-inducible protein was investigated using formalin-fixed, paraffin-embedded sections from 210 primary breast cancers.	Paraffin	88-96	taste 2 receptor member 64 pseudogene	Homo sapiens	18-21
9102728-6	1996	The purpose of this study was to verify the presence of ICAM-1 and VCAM-1 in paraffin-embedded tissue section of seven cases of U-NPC.	Paraffin	77-85	vascular cell adhesion molecule 1	Homo sapiens	67-73
21551913-5	1996	Histologic analysis of cresyl violet-stained paraffin sections was performed at 72 h. bcl-2 protein was expressed in CA1 neurons, a region that is injured, yet survives after seizures.	Paraffin	45-53	BCL2, apoptosis regulator	Rattus norvegicus	86-91
7494231-5	1995	METHODS: Retinoblastoma (Rb) and p16INK4 protein expression was determined by immunohistochemical analysis from archival paraffin specimens of 12 primary thoracic mesotheliomas and a nonmalignant pleural biopsy specimen.	Paraffin	121-129	cyclin dependent kinase inhibitor 2A	Homo sapiens	33-40
8732103-0	1996	[Detection of point mutation of p53 gene by silver staining PCR-SSCP in paraffin-embedded malignant fibrous histiocytoma].	Paraffin	72-80	tumor protein p53	Homo sapiens	32-35
8732103-1	1996	Silver staining PCR-SSCP method was used to detect point mutation of p53 gene in paraffin-embedded malignant fibrous histiocytoma (MFH) tissues.	Paraffin	81-89	tumor protein p53	Homo sapiens	69-72
7503357-2	1995	We describe here a novel microdissection technique employed to correlate HER2/neu (HER2) immunohistochemical staining with HER2 genetic analysis in formalin-fixed, paraffin-embedded breast tissue.	Paraffin	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-81
8550236-0	1995	E-cadherin expression in bladder cancer using formalin-fixed, paraffin-embedded tissues: correlation with histopathological grade, tumour stage and survival.	Paraffin	62-70	cadherin 1	Homo sapiens	0-10
8599466-1	1995	The accumulation of p53 protein was studied immunohistochemically on paraffin-embedded sections of 26 Spitz nevi (SNs), 26 primary invasive cutaneous malignant melanomas (MMs), 20 metastases of MM, and 17 ordinary compound nevi (CNs), using monoclonal antibody BP53-12.	Paraffin	69-77	tumor protein p53	Homo sapiens	20-23
8599466-4	1995	We believe that the immunohistochemical detection of p53 protein with the use of monoclonal antibodies such as BP53-12 on paraffin sections, especially when strong nuclear reactivity is demonstrated, may prove to be an adjunctive tool in the histopathologic differentiation of MM from SN.	Paraffin	122-130	tumor protein p53	Homo sapiens	53-56
8521382-6	1995	We have developed an immunohistochemical assay that allows us to assess p16 expression in formalin-fixed, paraffin-embedded tissues.	Paraffin	106-114	cyclin dependent kinase inhibitor 2A	Homo sapiens	72-75
8521382-15	1995	Our data show that: (a) immunohistochemistry may be a suitable modality to screen for RB and CDKN2/MTS1 abnormalities in paraffin-embedded tissues; (b) undetectable levels of p16 expression occur at a relatively high frequency; (c) p16 and pRB expression in common human malignancies is not mutually exclusive; (d) loss of function of both tumor suppressor genes appears to be a distinctly uncommon phenomenon; and (e) different types of carcinomas have variable rates of disturbance in the p16/pRB pathway.	Paraffin	121-129	cyclin dependent kinase inhibitor 2A	Homo sapiens	93-98
7503357-2	1995	We describe here a novel microdissection technique employed to correlate HER2/neu (HER2) immunohistochemical staining with HER2 genetic analysis in formalin-fixed, paraffin-embedded breast tissue.	Paraffin	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	73-77
7503357-2	1995	We describe here a novel microdissection technique employed to correlate HER2/neu (HER2) immunohistochemical staining with HER2 genetic analysis in formalin-fixed, paraffin-embedded breast tissue.	Paraffin	164-172	erb-b2 receptor tyrosine kinase 2	Homo sapiens	83-87
8747669-6	1995	During treatment with the angiotensin converting enzyme inhibitor captopril, the secretion rates tended to increase for unstimulated and paraffin-chewing stimulated whole saliva and for parotid secretion.	Paraffin	137-145	angiotensin I converting enzyme	Homo sapiens	26-55
8750153-4	1995	PATIENTS AND METHODS: A series of 133 primary breast cancers was investigated for expression of the Bcl-2 protein by immunohistochemistry of paraffin-embedded tissue sections.	Paraffin	141-149	BCL2 apoptosis regulator	Homo sapiens	100-105
8634783-0	1995	A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.	Paraffin	120-128	tumor protein p53	Homo sapiens	60-63
8640471-0	1995	Immunohistochemical detection of p53 overexpression in formalin-fixed, paraffin-embedded sections of endometrial carcinoma.	Paraffin	71-79	tumor protein p53	Homo sapiens	33-36
8522248-3	1995	METHODS: In a retrospective study of 196 patients with epithelial ovarian cancer, the amplification of the oncogenes HER-2/neu and INT-2 in the DNA of paraffin-embedded tumor cells was determined by quantitative PCR.	Paraffin	151-159	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-126
8924229-1	1995	We have performed this study to define the usefulness of an anti-human progenitor cell antigen-1(anti-CD34) to distinguish some kinds of soft tissue tumors in formalin-fixed, paraffin-embedded tissues.	Paraffin	175-183	CD34 molecule	Homo sapiens	102-106
8640471-2	1995	However using CM1 and an enhanced method based on microwave heating and protease digestion enabled the immunohistochemical detection of p53 overexpression in formalin-fixed, paraffin-embedded sections of endometrial carcinoma, although very few positive stainings were obtained without such an enhanced treatment.	Paraffin	174-182	tumor protein p53	Homo sapiens	136-139
8640471-7	1995	CONCLUSION: Enhanced immunodetection of p53 in paraffin-embedded tissues will provide a useful alternative to the usual fresh-tissue assay.	Paraffin	47-55	tumor protein p53	Homo sapiens	40-43
9815924-1	1995	Immunohistochemical (IHC) staining for p53 protein nuclear expression was evaluated in archival paraffin-embedded radical prostatectomy specimens from 139 patients with clinically localized prostate cancer followed up from 1 to 8 (mean, 4) years.	Paraffin	96-104	tumor protein p53	Homo sapiens	39-42
8751332-4	1995	To explore the differences in the expression of p53 protein in these two tumor types, we performed immunohistochemistry on 10 conventional pulmonary adenocarcinomas and 12 bronchioalveolar carcinomas on formalin-fixed and paraffin-embedded material, using the commercially available monoclonal antibody against the mutant p53 protein.	Paraffin	222-230	tumor protein p53	Homo sapiens	48-51
8595375-1	1995	A quantitative method of polymerase chain reaction (PCR) using both digoxigenin and radioactive labelled probes has been used for the detection of the c-erbB-2 proto-oncogene amplification in breast carcinomas with formalin-fixed paraffin-embedded tissue sections.	Paraffin	230-238	erb-b2 receptor tyrosine kinase 2	Homo sapiens	151-159
7477163-0	1995	More on p53 antigen loss in stored paraffin slides.	Paraffin	35-43	tumor protein p53	Homo sapiens	8-11
7478521-7	1995	Immunohistochemical staining of paraffin-embedded astrocytomas and glioblastomas showed that tumor cells and not contaminating normal cells were positive for p21.	Paraffin	32-40	cyclin dependent kinase inhibitor 1A	Homo sapiens	158-161
7485387-7	1995	However, in formalin-fixed, paraffin-embedded tissue, discrimination of active TGF-beta by CC(1-30) was lost and immunoreactivity was distinctly extracellular, as previously reported for this antibody.	Paraffin	28-36	transforming growth factor beta 1	Homo sapiens	79-87
7485387-10	1995	Two antibodies to peptides 78-109 showed mild to moderate preferential immunoreactivity with active TGF-beta only in paraffin sections.	Paraffin	117-125	transforming growth factor beta 1	Homo sapiens	100-108
8822113-1	1995	The expression of p53 and bcl-2 was immunohistochemically investigated in 61 formalin-fixed, paraffin-embedded invasive breast carcinomas.	Paraffin	93-101	tumor protein p53	Homo sapiens	18-21
8599924-5	1995	The results obtained in the ER immunocytochemical assay on aspirates and paraffin-sections using the antibody 1D5 and those obtained on frozen sections using the antibody H222 were closely similar.	Paraffin	73-81	estrogen receptor 1	Homo sapiens	28-30
7495699-13	1995	The use of these immunocytochemical techniques should enable the retrospective determination of possible changes in androgen receptor expression in a variety of archival paraffin-embedded tissues, including samples of the human central nervous system.	Paraffin	170-178	androgen receptor	Homo sapiens	116-133
8581156-9	1995	Immunoelectron microscopy using paraffin sections disclosed insulin-immunoreactive secretory granules in the cytoplasm.	Paraffin	32-40	insulin	Homo sapiens	60-67
7560893-0	1995	Patterns of immunoreactivity to an anti-fibronectin polyclonal antibody in formalin-fixed, paraffin-embedded oral tissues are dependent on methods of antigen retrieval.	Paraffin	91-99	fibronectin 1	Homo sapiens	40-51
8570558-3	1995	Our study set out to determine whether the immunohistochemical detection of uPA in formalin-fixed, paraffin-embedded primary breast cancer tissues is of prognostic relevance.	Paraffin	99-107	plasminogen activator, urokinase	Homo sapiens	76-79
7591299-0	1995	ERBB2 gene amplification detected by fluorescent differential polymerase chain reaction in paraffin-embedded breast carcinoma tissues.	Paraffin	91-99	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-5
8697990-7	1995	Immunohistochemistry (ABC method) on section of paraffin embedded tissue is a reliable method for detecting c-myc and p53 gene expression in HCC.	Paraffin	48-56	tumor protein p53	Homo sapiens	118-121
8745486-2	1995	METHODS: Expression of p53 was studied by immunohistochemistry in paraffin sections from 23 normal endometrium, 44 endometrial hyperplasia and 103 endometrial carcinoma.	Paraffin	66-74	tumor protein p53	Homo sapiens	23-26
7591299-4	1995	This fluorescent differential polymerase chain reaction (fd-PCR) method was used for quantificative determination of ERBB2 gene amplification in 195 formalin-fixed, paraffin-embedded breast carcinoma tissues.	Paraffin	165-173	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-122
7579380-6	1995	The results of immunohistochemistry analysis using a monoclonal anti-p53 antibody on paraffin-embedded specimens were compared with the SSCP data, the tumor karyotypes, and clinical course of each patient.	Paraffin	85-93	tumor protein p53	Homo sapiens	69-72
7560890-0	1995	Detection of P53 expression and S-phase cell fraction in paraffin-embedded tissue by a double-labeling technique.	Paraffin	57-65	tumor protein p53	Homo sapiens	13-16
8630898-2	1995	METHODS: p53 protein expression was studied by immunohistochemistry from paraffin embedded tissue in a series of 136 patients with malignant ovarian epithelial tumors.	Paraffin	73-81	tumor protein p53	Homo sapiens	9-12
7490678-0	1995	Detection of loss of heterozygosity of p53 gene in paraffin-embedded breast cancers by non-isotopic PCR-SSCP.	Paraffin	51-59	tumor protein p53	Homo sapiens	39-42
7490678-1	1995	A rapid non-isotopic PCR-SSCP (polymerase chain reaction-single-stranded conformation polymorphism) method was developed in this study to detect polymorphism and loss of heterozygosity (LOH) of p53 in formalin-fixed and paraffin-embedded samples of normal breast tissue and of breast cancer.	Paraffin	220-228	tumor protein p53	Homo sapiens	194-197
8552577-5	1995	Thirty-six esophageal resection specimens were studied, using a monoclonal antibody to the bcl-2 protein on fixed paraffin-embedded specimens.	Paraffin	114-122	BCL2 apoptosis regulator	Homo sapiens	91-96
8556954-1	1995	CD43 antibodies are best known for identifying normal and neoplastic T cells and a subset of neoplastic B cells in paraffin sections.	Paraffin	115-123	sialophorin	Homo sapiens	0-4
8771158-3	1995	Tumor p53 protein expression was detected by means of immunohistochemistry using the monoclonal antibody D07 on formalin fixed paraffin-embedded tissue sections.	Paraffin	127-135	tumor protein p53	Homo sapiens	6-9
8771158-7	1995	Our study suggested that the immunohistochemical assay was a simple method of detection of mutant p53 proteins in routinely processed paraffin-embedded tissues of primary mammary carcinoma.	Paraffin	134-142	tumor protein p53	Homo sapiens	98-101
8556954-12	1995	CD43 expression by B cells sometimes might be underestimated in paraffin sections because it is much weaker than on T cells.	Paraffin	64-72	sialophorin	Homo sapiens	0-4
7672793-2	1995	We evaluated the E-CD expression in 55 cases of urinary bladder papillary transitional cell carcinoma using a double-linked immunoalkaline phosphatase procedure on formalin-fixed, paraffin-embedded specimens quantified as percentage positive staining area with the Roche RPW image analyzer (Roche Image Analysis Systems, Elon College, NC).	Paraffin	180-188	cadherin 1	Homo sapiens	17-21
8575232-2	1995	Quantitative analysis of P53 protein expression was performed on paraffin-embedded tissues from 55 smooth muscle tumors of the gastrointestinal tract, using immunofluorescence and flow cytometry.	Paraffin	65-73	tumor protein p53	Homo sapiens	25-28
7488387-1	1995	The distribution of Bcl-2 oncoprotein was studied immunohistochemically in formaldehyde-fixed and paraffin-embedded reactive and neoplastic lymphoid tissue.	Paraffin	98-106	BCL2 apoptosis regulator	Homo sapiens	20-25
8522289-3	1995	Expression of bcl-2 protein was analysed in 30 cases of thymoma by immunohistological staining of paraffin-embedded tissue.	Paraffin	98-106	BCL2 apoptosis regulator	Homo sapiens	14-19
8748236-4	1995	In paraffin sections of prostatic tumors immunoreactive bFGF was found in fibroblasts, smooth muscle cells, and endothelial cells.	Paraffin	3-11	fibroblast growth factor 2	Homo sapiens	56-60
7472782-3	1995	p53 expression was evaluated by immunohistochemistry in formalin-fixed, paraffin-embedded tissue from 23 leiomyosarcomas, 10 tumours of uncertain malignant potential (TUMPs), and 18 leiomyomas.	Paraffin	72-80	tumor protein p53	Homo sapiens	0-3
8697968-3	1995	The expression of p53 protein was also immunohistochemically studied in formalin-fixed paraffin embedded specimens of 76 colorectal adenocarcinomas and 112 colorectal polyps.	Paraffin	87-95	tumor protein p53	Homo sapiens	18-21
7474461-0	1995	[A study on immunohistochemical detection of estrogen receptor in the breast cancer tissue--a comparison between routinely paraffin-embedded and frozen sections].	Paraffin	123-131	estrogen receptor 1	Homo sapiens	45-62
7474461-4	1995	However, it is noteworthy that estrogen receptor is detectable with paraffin-embedded section although the rate of positivity is low.	Paraffin	68-76	estrogen receptor 1	Homo sapiens	31-48
7474461-5	1995	It is desirable that further development of the antibody for estrogen receptor in the breast cancer tissue with paraffin-embedded section will be continued.	Paraffin	112-120	estrogen receptor 1	Homo sapiens	61-78
7637331-4	1995	EXPERIMENTAL DESIGN: AR was studied in paraffin sections from 90 men for whom endocrine response, survival (except one case), and/or biochemical AR was known.	Paraffin	39-47	androgen receptor	Homo sapiens	21-23
7632952-4	1995	In this report, we describe a new anti-CD79a monoclonal antibody, JCB117, which reacts with human B cells in paraffin embedded tissue sections, including decalcified bone marrow trephines.	Paraffin	109-117	CD79a molecule	Homo sapiens	39-44
8520001-4	1995	The expression of bcl-2 protein was evaluated using an immunoalkaline phosphatase technique in 54 pre-operative breast cancer aspirates and in paraffin-embedded sections from 20 matched surgical specimens.	Paraffin	143-151	BCL2 apoptosis regulator	Homo sapiens	18-23
7496162-8	1995	Eight out of 11 cases from whom samples of paraffin-embedded tissue were available showed more prominent staining for HMB-45 than for S-100.	Paraffin	43-51	S100 calcium binding protein B	Homo sapiens	134-139
7657383-0	1995	Detection of TP53 gene mutation in human meningiomas: a study using immunohistochemistry, polymerase chain reaction/single-strand conformation polymorphism and DNA sequencing techniques on paraffin-embedded samples.	Paraffin	189-197	tumor protein p53	Homo sapiens	13-17
16696005-1	1995	Aim-To investigate the expression of p53 protein in invasive squamous cell carcinoma (SCC) of the larynx and dysplasia in relation to histological grade and tobacco smoking.Method-Paraffin wax embedded tissue sections from 41 cases of invasive SCC of the larynx, 28 cases of dysplasia and 14 control laryngeal biopsy specimens were studied immunohistochemically using two anti-p53 monoclonal antibodies (DO7 and 1801).	Paraffin	180-192	tumor protein p53	Homo sapiens	37-40
21597769-2	1995	In the present study, the expression of u-PA was immunohistochemically investigated in various thyroid tissues by using formaline-fixed, paraffin-embedded tissue sections.	Paraffin	137-145	plasminogen activator, urokinase	Homo sapiens	40-44
8625105-5	1995	Immunohistochemical staining for p53 was performed on paraffin embedded tissue of each case.	Paraffin	54-62	tumor protein p53	Homo sapiens	33-36
7564160-7	1995	The analysis of two paraffin-embedded tumors suggested that changes in the size of the pericentromeric hybridization signals of chromosome 12 may be attributed to the presence of i(12)(p10).	Paraffin	20-28	S100 calcium binding protein A10	Homo sapiens	185-188
7781795-4	1995	To this end, the expression of EGF-R mRNA and protein by non-radioactive in-situ hybridization and immunohistochemistry, respectively, were determined on histological preparations of formalin-fixed paraffin-embedded colorectal surgical specimens.	Paraffin	198-206	epidermal growth factor receptor	Homo sapiens	31-36
7779717-0	1995	Immunohistochemical assay for epidermal growth factor receptor on paraffin-embedded sections: validation against ligand-binding assay and clinical relevance in breast cancer.	Paraffin	66-74	epidermal growth factor receptor	Homo sapiens	30-62
7667210-0	1995	[Immunohistochemical detection of pS2 protein in paraffin sections of breast carcinoma tissue.	Paraffin	49-57	taste 2 receptor member 64 pseudogene	Homo sapiens	34-37
7667210-5	1995	In 162 cases of primary breast cancer, pS2 was tested by immunohistochemical procedures on formalin-fixed and paraffin-embedded tissues.	Paraffin	110-118	taste 2 receptor member 64 pseudogene	Homo sapiens	39-42
7546049-2	1995	Quantitation of DNA ploidy was determined on Feulgen-stained touch imprints with an image analyzer, whereas localization of the immunohistochemical reaction of Erb-B2 and p53 protein was evaluated in paraffin-embedded tumor specimens with microscopy.	Paraffin	200-208	tumor protein p53	Homo sapiens	171-174
7636625-1	1995	HECD-1 monoclonal antibody has been used to localize E-cadherin, a calcium-dependent cell-cell adhesion molecule, in microwave-treated, paraffin-embedded sections from 53 cases of cervical intraepithelial neoplasia (CIN) (11 CIN I, 22 CIN II, and 20 CIN III), 16 invasive cervical squamous cell carcinomas, and seven metastases.	Paraffin	136-144	cadherin 1	Homo sapiens	53-63
7715901-2	1995	EGFR gene amplification was examined by slot-blot hybridization using DNA extracted from formalin-fixed, paraffin-embedded tissues.	Paraffin	105-113	epidermal growth factor receptor	Homo sapiens	0-4
8580833-10	1995	Paraffin section immunophenotyping demonstrated reactivity of the atypical cells for CD15, 43, 45RO, 45RB, 68, lysozyme and/or S100.	Paraffin	0-8	fucosyltransferase 4	Homo sapiens	85-89
8580833-10	1995	Paraffin section immunophenotyping demonstrated reactivity of the atypical cells for CD15, 43, 45RO, 45RB, 68, lysozyme and/or S100.	Paraffin	0-8	lysozyme	Homo sapiens	111-119
7645934-0	1995	Correlation of P-glycoprotein overexpression and cellular prognostic factors in formalin-fixed, paraffin-embedded tumor samples from breast cancer patients.	Paraffin	96-104	ATP binding cassette subfamily B member 1	Homo sapiens	15-29
7645934-2	1995	We have been able to verify this previously on fresh-frozen tumor samples, but up to now P-glycoprotein detection on formalin-fixed, paraffin-embedded material has generally been unsatisfactory.	Paraffin	133-141	ATP binding cassette subfamily B member 1	Homo sapiens	89-103
7647329-1	1995	To assess the practical prognostic value of pS2, we evaluated its expression by immunohistochemistry in paraffin-embedded tissue from 942 previously untreated invasive ductal carcinomas (IDC) resected in our center between 1980 and 1986.	Paraffin	104-112	taste 2 receptor member 64 pseudogene	Homo sapiens	44-47
7607382-12	1995	In this study, the determination of EGF-R in formalin-fixed, paraffin-embedded tumour samples proved feasible.	Paraffin	61-69	epidermal growth factor receptor	Homo sapiens	36-41
7739705-0	1995	p53 antigen loss in stored paraffin slides.	Paraffin	27-35	tumor protein p53	Homo sapiens	0-3
7607381-2	1995	It is possible to demonstrate the presence of mutant p 53 protein types in tumour cell nuclei by applying immunohistochemical procedures to paraffin sections (Clon DO 1, Dianova).	Paraffin	140-148	tumor protein p53	Homo sapiens	53-57
7607382-0	1995	[Immunohistochemical detection of epidermal growth factor receptor (EGF-R) in paraffin sections of breast carcinoma tissue: correlation and clinical significance].	Paraffin	78-86	epidermal growth factor receptor	Homo sapiens	34-66
7607382-0	1995	[Immunohistochemical detection of epidermal growth factor receptor (EGF-R) in paraffin sections of breast carcinoma tissue: correlation and clinical significance].	Paraffin	78-86	epidermal growth factor receptor	Homo sapiens	68-73
7607382-4	1995	Studies with immunohistochemical analyses of EGF-R overexpression in formalin-fixed, paraffin-embedded tumour samples are rare.	Paraffin	85-93	epidermal growth factor receptor	Homo sapiens	45-50
7607382-5	1995	In a retrospective study, we examined the clinical data from 142 patients and the EGF-R expression in their formalin-fixed, paraffin-embedded tumour samples.	Paraffin	124-132	epidermal growth factor receptor	Homo sapiens	82-87
7738518-2	1995	In this study, the tissue specificities of one polyclonal (pAb) and three monoclonal (mAbs) antibodies to mammalian P-glycoprotein were identified in paraffin-embedded, parasagittal whole-body sections of the guppy Poecilia reticulata.	Paraffin	150-158	ATP binding cassette subfamily B member 1	Homo sapiens	116-130
11091532-8	1995	As a summary from our studies, c-erbB-2 immunohistochemical staining on paraffin sections might be the best independent prognostic factor in axillary node-negative breast cancers.	Paraffin	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-39
7697606-4	1995	METHODS: Overexpression of the c-erbB-2 protein was studied by immunohistochemistry in paraffin-embedded tumor tissue from 106 patients with ovarian cancer.	Paraffin	87-95	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-39
7615358-2	1995	Mutations in exons 5 through 8 of the p53 gene were identified by a denaturing gradient gel electrophoresis (DGGE) assay and cycle sequencing, whereas p53 protein accumulation was detected in paraffin-embedded tissue by immunostaining using 2 different murine monoclonal antibodies (MAbs) (BP53-12 and DO7).	Paraffin	192-200	tumor protein p53	Homo sapiens	151-154
7576299-1	1995	The expression of the p53 protein (p53) was compared with those of several oncogenes including c-fos (Fos), c-jun (Jun), and epidermal growth factor receptor (EGFR1) using immunohistochemistry in frozen and paraffin-embedded sections of 25 basal cell carcinomas (BCCs) to find out any correlation between p53 and oncogenes in the pathogenesis of human BCC.	Paraffin	207-215	tumor protein p53	Homo sapiens	22-25
7726729-0	1995	A microwave method that enhances detection of aberrant p53 expression in formalin-fixed, paraffin-embedded tissues.	Paraffin	89-97	tumor protein p53	Homo sapiens	55-58
7726729-10	1995	CONCLUSIONS: Microwave pretreatment in conjunction with the use of either PAb1801 or DO7 is highly efficacious in the immunohistochemical detection of aberrant p53 expression in formalin-fixed, paraffin-embedded tissues.	Paraffin	194-202	tumor protein p53	Homo sapiens	160-163
7723282-6	1995	EGF-R expression was detected by immunohistochemistry on paraffin-embedded tumor sections of the same specimens.	Paraffin	57-65	epidermal growth factor receptor	Homo sapiens	0-5
7790991-2	1995	Expression of the bcl-2 protein within the Hodgkin and Reed-Sternberg (HRS) cells was investigated in 86 cases of HD by immunohistochemistry on cryostat or paraffin sections.	Paraffin	156-164	BCL2 apoptosis regulator	Homo sapiens	18-23
7734516-12	1995	Immunohistochemical analysis of the same paraffin-embedded sections showed that infectivity and level of expression of p53 in lung tissue were dose-dependent.	Paraffin	41-49	tumor protein p53	Homo sapiens	119-122
7882282-5	1995	METHODS: Immunohistochemical staining for HER was performed on 10% formalin fixed paraffin embedded primary carcinomas from 440 patients with negative axillary lymph nodes with a median follow-up of 119 months.	Paraffin	82-90	erb-b2 receptor tyrosine kinase 2	Homo sapiens	42-45
7774494-1	1995	Expression of the neu oncogene has been extensively examined in frozen and paraffin section breast cancers; however, very few studies examine neu oncoprotein oncoprotein expression in fine-needle aspirates.	Paraffin	75-83	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-21
7774494-2	1995	To this effect, we compared the expression of neu oncoprotein in formalin-fixed paraffin-embedded breast cancers and the corresponding fine-needle aspirates of these cancers.	Paraffin	80-88	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-49
7774494-3	1995	There was 100% correlation between the expression of neu oncoprotein in the paraffin-embedded breast cancers and the fine-needle aspirates, indicating the suitability of fine-needle aspirates for the expression of neu oncoprotein in breast cancers.	Paraffin	76-84	erb-b2 receptor tyrosine kinase 2	Homo sapiens	53-56
7538162-1	1995	A reverse transcriptase nested polymerase reaction (RT-nPCR) method has been developed to detect the presence of a tumour-specific translocation in archival formalin-fixed, paraffin-embedded tissue.	Paraffin	173-181	nasopharyngeal carcinoma-related protein	Homo sapiens	55-59
7856554-2	1995	The aim of this study is to investigate whether hepatitis B e antigen (HBeAg) reactivity can be detected on formalin-fixed, paraffin-embedded liver tissue, and whether immunohistochemical detection of intrahepatic HBeAg may help to distinguish between "wild-type" and "eminus" hepatitis B virus (HBV) infection.	Paraffin	124-132	capsid protein;pre-capsid protein	Hepatitis B virus	48-77
7856554-8	1995	These results show that HBeAg can be detected in formalin-fixed, paraffin-embedded liver specimens, and the method is sensitive and specific.	Paraffin	65-73	capsid protein;pre-capsid protein	Hepatitis B virus	24-29
7620345-11	1995	We demonstrate that antigen retrieval techniques increase p53 immunoreactivity in paraffin embedded melanocytic tissues.	Paraffin	82-90	tumor protein p53	Homo sapiens	58-61
7889478-3	1995	METHODS: Paraffin blocks were prepared for staining with antibody against S-100 protein in 121 cases of gastric cancer.	Paraffin	9-17	S100 calcium binding protein A1	Homo sapiens	74-79
7796648-2	1995	Detection of overexpression of p53 protein was carried out by immunohistochemical staining (IHS) using the monoclonal antibody DO-1 on paraffin sections.	Paraffin	135-143	tumor protein p53	Homo sapiens	31-34
7695015-4	1995	In this study, we analyzed bcl-2 protein expression in cutaneous malignant melanoma (MM) (29 cases) and benign melanocytic nevi (BMN) (35 cases) using a high specific anti-bcl-2 monoclonal antibody with a standard three-step immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue sections.	Paraffin	271-279	BCL2 apoptosis regulator	Homo sapiens	27-32
7556591-6	1995	Nuclear p53 immunoreactivity was assessed using a monoclonal antibody, DO-1, on Formalin-fixed paraffin-embedded specimens.	Paraffin	95-103	tumor protein p53	Homo sapiens	8-11
7896192-3	1995	A combined reverse transcription/polymerase chain reaction was used to study E6/E7 transcription patterns in fresh and/or fixed paraffin-embedded tissues of HPV 16-positive cervical cancers.	Paraffin	128-136	protein E6*;transforming protein E6	Human papillomavirus type 16	77-82
7860045-1	1995	Several studies of benign breast lesions using methacran-fixed, paraffin-embedded tissues and cytological preparations have suggested that p53 accumulation in these lesions as detected by immunohistochemical (IHC) staining is rare to absent.	Paraffin	64-72	tumor protein p53	Homo sapiens	139-142
7745116-2	1995	METHODS: The expression of p53, Rb and bcl-2 proteins in paraffin wax embedded tonsil tissue sections was detected by immunohistochemistry using an (APAAP) technique following microwave irradiation.	Paraffin	57-69	tumor protein p53	Homo sapiens	27-30
7860046-5	1995	Image analysis showed that the surfaces positive with anti-p53 and the staining intensity were decreased (P &lt; .01) on paraffin sections.	Paraffin	121-129	tumor protein p53	Homo sapiens	59-62
7745116-2	1995	METHODS: The expression of p53, Rb and bcl-2 proteins in paraffin wax embedded tonsil tissue sections was detected by immunohistochemistry using an (APAAP) technique following microwave irradiation.	Paraffin	57-69	BCL2 apoptosis regulator	Homo sapiens	39-44
7856728-3	1995	We describe an immunohistochemical analysis of fixed, paraffin-embedded tissue using both a polyclonal rabbit and a monoclonal mouse antibody to the Bcl-2 protein.	Paraffin	54-62	BCL2 apoptosis regulator	Homo sapiens	149-154
7531794-5	1995	EXPERIMENTAL DESIGN: We used nucleic acid in situ hybridization to detect bFGF-specific mRNA transcripts within MCs in formalin-fixed, paraffin-embedded specimens of nonlesional human skin and skin containing increased numbers of MCs, including granulation tissues, benign cutaneous mastocytosis, and solitary neurofibromas.	Paraffin	135-143	fibroblast growth factor 2	Homo sapiens	74-78
7742922-0	1995	Antigen retrieval for bcl-2 protein in formalin-fixed, paraffin-embedded sections.	Paraffin	55-63	BCL2 apoptosis regulator	Homo sapiens	22-27
7814152-3	1995	Bcl-2 protein was detected by immunohistochemistry on paraffin-embedded tissue sections.	Paraffin	54-62	BCL2 apoptosis regulator	Homo sapiens	0-5
7852482-5	1995	Putative p53 mutations were detected by immunohistochemistry on paraffin-embedded sections using polyclonal CM-1 and monoclonal DO-7 and PAb1801 antibodies.	Paraffin	64-72	tumor protein p53	Homo sapiens	9-12
7618442-1	1995	The hippocampal distribution of mRNA for the N-methyl-D-aspartate (NMDA) receptor subunit 1 (NR1) was examined by non-radioactive in situ hybridization in 21 archival formalin-fixed and paraffin-embedded surgical specimens from patients with pharmacoresistant chronic epilepsy and in normal control specimens obtained at autopsy.	Paraffin	186-194	glutamate ionotropic receptor NMDA type subunit 1	Homo sapiens	45-96
7669946-2	1995	We therefore applied paraffin-section immunohistochemistry, which permits detailed morphological analysis of the tissue distribution of fibronectin, in order to evaluate the alterations of fibronectin in terms of quantity and localization during the progression of atherosclerosis in humans.	Paraffin	21-29	fibronectin 1	Homo sapiens	136-147
7578871-1	1995	We describe the distribution of interleukin-6 and interleukin-1 alpha in thyroid tissues obtained from patients with autoimmune diseases or neoplastic thyroid disorders employing immunohistochemistry in sections from paraffin embedded tissue blocks.	Paraffin	217-225	interleukin 6	Homo sapiens	32-45
7819040-5	1995	The immunohistochemical detection of mutations of the p53 gene has been demonstrated to be a reliable, easily performed and thereby widely available technique for the investigation of fresh-frozen or paraffin-embedded tumour specimens.	Paraffin	200-208	tumor protein p53	Homo sapiens	54-57
7718322-1	1995	Epidermal growth factor receptor (EGFr) levels were evaluated in paraffin-embedded tumour specimens of non-small cell lung cancer (NSCLC) from 176 patients who underwent surgical resection.	Paraffin	65-73	epidermal growth factor receptor	Homo sapiens	34-38
7713486-1	1995	Bcl-2 protein expression was studied in a series of 58 MALT lymphomas using a monoclonal antibody which recognises this protein in routinely processed paraffin embedded tissue.	Paraffin	151-159	BCL2 apoptosis regulator	Homo sapiens	0-5
21597698-1	1995	Overexpression of PCNA (more than 25% positive tumour cells) and positivity of c-erbB-2 oncoprotein were immunohistochemically demonstrated in 490 formalin-fixed and paraffin-embedded breast carcinomas.	Paraffin	166-174	erb-b2 receptor tyrosine kinase 2	Homo sapiens	79-87
7757285-1	1995	We have used an avidin-biotin immunoperoxidase technique to localise epithelial cadherin (E-cadherin), a calcium-dependent cell-cell adhesion molecule, in 107 paraffin-embedded sections from 93 patients consisting of 24 with colorectal adenoma, 55 with rectal carcinoma and 14 with liver metastases.	Paraffin	159-167	cadherin 1	Homo sapiens	69-88
7706515-1	1995	AIM: To develop polymerase chain reaction based artificial restriction fragment length polymorphism (artificial RFLP PCR) assays for DR3 and DR4 alleles of the multiallelic DRB1 locus and to apply them to paraffin wax embedded archival material.	Paraffin	205-217	major histocompatibility complex, class II, DR beta 1	Homo sapiens	173-177
7706515-5	1995	Typing of 10 paraffin wax embedded samples using artificial RFLP PCR was in complete agreement with previous typing at the DRB1 locus.	Paraffin	13-25	major histocompatibility complex, class II, DR beta 1	Homo sapiens	123-127
7704245-1	1995	The expression of p53 protein was studied in formalin-fixed paraffin-embedded specimens of 41 well-differentiated adenocarcinomas of the gall-bladder, six cases of acute cholecystitis and 23 cases of chronic cholecystitis, using a monoclonal p53 (PAb 1801) antibody and streptavidin-biotin.	Paraffin	60-68	tumor protein p53	Homo sapiens	18-21
8548125-7	1995	In conclusion, AD2 recognizes the outer arm dynein heavy chains of healthy cilia and may be useful in diagnosing and classifying PCD light microscopically especially when only paraffin-embedded specimens are available.	Paraffin	176-184	apolipoprotein E	Homo sapiens	15-18
7527509-5	1994	In the second part of the study, accumulation of p53 protein was determined in 42 archival paraffin-embedded specimens from oral leukoplakia and correlated with the degree of epithelial dysplasia.	Paraffin	91-99	tumor protein p53	Homo sapiens	49-52
7656779-1	1995	Quantitative DNA dot blot hybridization and immunohistochemical method were employed to detect amplification and overexpression of proto-oncogene c-erbB2 in 101 paraffin-embedded breast cancers.	Paraffin	161-169	erb-b2 receptor tyrosine kinase 2	Homo sapiens	131-153
7895575-9	1994	(2) Paraffin-embedded cell blocks made from hepatic aspirate material are suitable for immunostaining with polyclonal CEA antibody.	Paraffin	4-12	CEA cell adhesion molecule 3	Homo sapiens	118-121
7876377-2	1994	METHODS: Immunocytochemistry for p53 was performed in 65 specimens of formalin fixed, paraffin wax embedded cervical tissue using a polyclonal antibody against recombinant p53.	Paraffin	86-98	tumor protein p53	Homo sapiens	33-36
7983360-1	1994	We developed an in situ hybridization technique for measurement of proliferative cell numbers through detection of histone mRNA in routinely fixed, paraffin-embedded tissue sections.	Paraffin	148-156	H2B clustered histone 1	Rattus norvegicus	115-122
7884585-3	1994	We have used an avidin-biotin immunoperoxidase technique to localize E-cadherin in microwave-treated, paraffin-embedded sections from 36 patients with pancreatic adenocarcinomas.	Paraffin	102-110	cadherin 1	Homo sapiens	69-79
7977649-2	1994	The prognostic significance of Bcl-2 protein expression was investigated by immunocytochemistry from paraffin-embedded tissue in a series of 174 women with breast cancer, treated with radical surgery with or without regional radiotherapy, and who had been followed up for the median of 31 years or until death.	Paraffin	101-109	BCL2 apoptosis regulator	Homo sapiens	31-36
7942634-1	1994	Immunohistochemical staining for the p53 protein was performed in microwave-fixed, paraffin-embedded sections of normal, premalignant and malignant tissues of the female genital tract using a monoclonal antibody, PAb 1801.	Paraffin	83-91	tumor protein p53	Homo sapiens	37-40
7720108-0	1994	[Detection of point mutation of p53 gene by non-isotopic PCR-SSCP in paraffin-embedded breast cancer tissue].	Paraffin	69-77	tumor protein p53	Homo sapiens	32-35
7720108-1	1994	Non-isotopic PCR-SSCP method was used to detect point mutation of p53 gene in paraffin-embedded breast cancers.	Paraffin	78-86	tumor protein p53	Homo sapiens	66-69
7531507-5	1994	Paraffin ovarian sections were pretreated with proteinase K and then end-labeled with biotinylated deoxyuridine triphosphate (dUTP) by incubation with the enzyme terminal deoxynucleotidyl transferase (TDT).	Paraffin	0-8	DNA nucleotidylexotransferase	Rattus norvegicus	162-199
7531507-5	1994	Paraffin ovarian sections were pretreated with proteinase K and then end-labeled with biotinylated deoxyuridine triphosphate (dUTP) by incubation with the enzyme terminal deoxynucleotidyl transferase (TDT).	Paraffin	0-8	DNA nucleotidylexotransferase	Rattus norvegicus	201-204
7868086-1	1994	The prognostic significance of c-erbB-2 expression was studied in paraffin wax embedded colorectal cancer tissue using a monoclonal antibody.	Paraffin	66-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-39
11578436-3	1994	We also examined the expression of p53 in paraffin tissues by immunohistochemical staining and determined the incidence of human papillomavirus (HPV) sequences in the same tissues by multitype PCR analysis to correlate them to the allelic loss on chromosome 17p13 and p53 mutation.	Paraffin	42-50	tumor protein p53	Homo sapiens	35-38
7959668-1	1994	Immunohistochemical expression of the cellular phosphoprotein p53 was investigated in archival, formalin-fixed, and paraffin-embedded surgical breast tissue specimens from 543 patients using the polyclonal antibody CM-1.	Paraffin	116-124	tumor protein p53	Homo sapiens	62-65
7959674-4	1994	The polymerase chain reaction (PCR) of the rearranged T-cell receptor beta chain genome (TcR beta) derived from paraffin sections showed monoclonality.	Paraffin	112-120	T cell receptor beta locus	Homo sapiens	89-97
7962351-5	1994	Putative p53 mutations were detected by immunohistochemistry on paraffin-embedded sections using polyclonal CM-1 and monoclonal DO-7 and PAb1801 antibodies.	Paraffin	64-72	tumor protein p53	Homo sapiens	9-12
7580888-2	1994	Sequences of the p53 gene have been obtained from DNA extracted from frozen and formalin-fixed paraffin-embedded cancer tissues.	Paraffin	95-103	tumor protein p53	Homo sapiens	17-20
7848689-1	1994	BACKGROUND AND METHODS: p53 protein expression was studied immunohistochemically in 73 colorectal adenocarcinomas, using monoclonal antibody D07 in alcohol fixed, paraffin embedded tissue.	Paraffin	163-171	tumor protein p53	Homo sapiens	24-27
8092400-4	1994	All six of the specimens (from five patients) for which paraffin tissue was available marked as B cell phenotype and were positive for bcl-2 protein.	Paraffin	56-64	BCL2 apoptosis regulator	Homo sapiens	135-140
7931487-2	1994	PATIENTS AND METHODS: The S-phase fraction (SPF) size was determined by DNA flow cytometry from paraffin-embedded tissue obtained at diagnosis from 490 patients with non-Hodgkin"s lymphoma, diagnosed in a defined geographic area from 1970 to 1991.	Paraffin	96-104	SEC14 like lipid binding 2	Homo sapiens	44-47
7838839-0	1994	Immunocytochemical detection of cyclin A and cyclin D in formalin-fixed, paraffin-embedded tissues: novel, pertinent markers of cell proliferation.	Paraffin	73-81	cyclin A2	Homo sapiens	32-40
7823248-2	1994	Genomic p53 was amplified by the polymerase chain reaction (PCR) from paraffin-embedded sections of tumour and non-tumour tissue.	Paraffin	70-78	tumor protein p53	Homo sapiens	8-11
7922972-6	1994	METHODS: p53 expression in formalin fixed, paraffin embedded samples of 204 patients with primary squamous cell carcinoma of the esophagus, who underwent esophageal resection, were analyzed immunohistochemically with DO-1, a monoclonal antibody that detects wild-type and mutant forms of p53.	Paraffin	43-51	tumor protein p53	Homo sapiens	9-12
7992894-5	1994	Standard immunoperoxidase methods were used to identify type IV collagen, laminin, and fibronectin in paraffin sections.	Paraffin	102-110	fibronectin 1	Homo sapiens	87-98
7530851-0	1994	p53 immunolabeling in archival paraffin-embedded tissues: optimal protocol based on microwave heating for eight antibodies on lung carcinomas.	Paraffin	31-39	tumor protein p53	Homo sapiens	0-3
21559604-2	1994	Positive staining for p53 protein was detected in 44 of 71 (62%) of these tumors on paraffin-embedded tissue, even in dysplastic areas.	Paraffin	84-92	tumor protein p53	Homo sapiens	22-25
7805554-1	1994	The monoclonal antibody to p53 and a rapid immunohistochemical method were used in this study to detect p53 expression in 50 paraffin-embedded breast cancers and 7 benign hyperplastic diseases of breast.	Paraffin	125-133	tumor protein p53	Homo sapiens	104-107
7822215-0	1994	Sensitive detection of human growth hormone mRNA in routinely formalin-fixed, paraffin-embedded transgenic mouse tissues by non-isotopic in situ hybridization.	Paraffin	78-86	growth hormone 1	Homo sapiens	29-43
7822215-1	1994	A sensitive technique of non-isotopic in situ hybridization (NISH) is presented, which permits the detection of human growth hormone (hGH) mRNA in routinely formalin-fixed, paraffin-embedded transgenic mouse tissues and human post mortem pituitaries; the latter were used as positive tissue controls in this study.	Paraffin	173-181	growth hormone 1	Homo sapiens	118-132
7928628-0	1994	Nuclear accumulation of p53 protein correlates with mutations in the p53 gene on archival paraffin-embedded tissues of human breast cancer.	Paraffin	90-98	tumor protein p53	Homo sapiens	24-27
7928628-0	1994	Nuclear accumulation of p53 protein correlates with mutations in the p53 gene on archival paraffin-embedded tissues of human breast cancer.	Paraffin	90-98	tumor protein p53	Homo sapiens	69-72
7928628-8	1994	We conclude that the immunohistochemical detection of nuclear p53 protein accumulation is highly associated with p53 gene mutations in archival paraffin-embedded tissues, and that this method is useful for rapid screening of p53 abnormalities.	Paraffin	144-152	tumor protein p53	Homo sapiens	62-65
7708439-9	1994	P53 was investigated by immunohistochemistry, using a monoclonal anti-p53 antibody (DO-7), on formalin fixed, paraffin embedded tissue.	Paraffin	110-118	tumor protein p53	Homo sapiens	0-3
7882774-1	1994	Quantitative analysis of p53 protein expression was performed on paraffin-embedded tissues from 55 smooth muscle tumors of the gastrointestinal tract by using immunofluorescence and flow cytometry.	Paraffin	65-73	tumor protein p53	Homo sapiens	25-28
7913577-10	1994	Both p53 protein and p185 antibodies work well on routine, formalin-fixed, paraffin-embedded tissue and are easily used in routine diagnostic procedures.	Paraffin	75-83	tumor protein p53	Homo sapiens	5-8
7931842-4	1994	We examined 62 endoscopic oesophageal biopsies and 36 oesophageal resections for p53 overexpression using the monoclonal antibody DO-7 on paraffin-embedded tissue.	Paraffin	138-146	tumor protein p53	Homo sapiens	81-84
7545945-6	1994	p24 antigen was detected by immunocytochemical staining of paraffin-fixed sections in the germinal centers within lymphoid tissue, although little or no antigen was found in areas of lymph node or spleen containing T lymphocytes from either presymptomatic patients or patients with AIDS.	Paraffin	59-67	transmembrane p24 trafficking protein 2	Homo sapiens	0-3
7518652-5	1994	We report here that CD34 monoclonal antibodies reacted with 11 of 14 solitary fibrous tumors in paraffin sections.	Paraffin	96-104	CD34 molecule	Homo sapiens	20-24
8027537-0	1994	Immunohistochemical detection of the androgen receptor with monoclonal antibody F39.4 in routinely processed, paraffin-embedded human tissues after microwave pre-treatment.	Paraffin	110-118	androgen receptor	Homo sapiens	37-54
8027537-1	1994	We describe the immunohistochemical detection of the human androgen receptor (AR) in routinely processed, paraffin-embedded tissue with the monoclonal antibody (MAb) F39.4.	Paraffin	106-114	androgen receptor	Homo sapiens	59-76
8027537-1	1994	We describe the immunohistochemical detection of the human androgen receptor (AR) in routinely processed, paraffin-embedded tissue with the monoclonal antibody (MAb) F39.4.	Paraffin	106-114	androgen receptor	Homo sapiens	78-80
8027537-6	1994	After prolonged fixation times or long-term storage of paraffin-embedded tissue, the staining intensity for the AR did not deteriorate.	Paraffin	55-63	androgen receptor	Homo sapiens	112-114
7911296-4	1994	METHODS: The differential polymerase chain reaction (PCR) procedure was used to detect amplification of the HER-2/neu gene in DNA samples from the novel human gastrinoma cell line (PT) and from paraffin-embedded samples of gastrinomas.	Paraffin	194-202	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-117
7911272-3	1994	We used immunocytochemical techniques to retrospectively study the expression of the c-erb B-2 oncogene product in formalin-fixed, paraffin-embedded trophoblastic tissues as a potential indicator of the development of persistent gestational trophoblastic disease.	Paraffin	131-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	85-94
7911456-1	1994	P-glycoprotein expression was analyzed on 137 formalin-fixed, paraffin-embedded human tumours by monoclonal antibody (MAb) MC57.	Paraffin	62-70	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
7520411-3	1994	Recently there has been controversy surrounding reports of B-cell antigen expression by Reed-Sternberg and related cells, and we have therefore studied 108 cases of Hodgkin"s disease immunohistochemically using a novel antibody which detects mb-1 protein in paraffin sections.	Paraffin	258-266	CD79a molecule	Homo sapiens	242-246
8204009-0	1994	Estrogen receptor detection in paraffin sections of adenocarcinoma of the colon, pancreas, and lung.	Paraffin	31-39	estrogen receptor 1	Homo sapiens	0-17
8204009-2	1994	Estrogen receptor status was determined by immunohistochemical methods using the ER-ICA (Abbott Laboratories, North Chicago, Ill) antibody on paraffin sections.	Paraffin	142-150	estrogen receptor 1	Homo sapiens	0-17
8200229-3	1994	METHODS: IgG1 monoclonal antibody to human p53 protein (PAb 1801) was used to detect p53 in formalin-fixed, paraffin-embedded archival tumors resected from 84 patients with tumor limited to the bowel wall.	Paraffin	108-116	tumor protein p53	Homo sapiens	85-88
8189040-0	1994	Androgen receptor immunostaining and its tissue distribution in formalin-fixed, paraffin-embedded sections after microwave treatment.	Paraffin	80-88	androgen receptor	Homo sapiens	0-17
8189040-1	1994	We used microwave (MW) oven heat treatment to unmask human androgen receptor (AR) immunostaining in formalin-fixed, paraffin-embedded tissue.	Paraffin	116-124	androgen receptor	Homo sapiens	59-76
8189040-1	1994	We used microwave (MW) oven heat treatment to unmask human androgen receptor (AR) immunostaining in formalin-fixed, paraffin-embedded tissue.	Paraffin	116-124	androgen receptor	Homo sapiens	78-80
8189040-8	1994	MW heat treatment of tissue samples in an excellent method of localizing AR antigenicity, enabling immunohistochemical evaluation of AR status in formalin-fixed, paraffin-embedded material.	Paraffin	162-170	androgen receptor	Homo sapiens	73-75
8189040-8	1994	MW heat treatment of tissue samples in an excellent method of localizing AR antigenicity, enabling immunohistochemical evaluation of AR status in formalin-fixed, paraffin-embedded material.	Paraffin	162-170	androgen receptor	Homo sapiens	133-135
7937720-10	1994	Three of eleven cases, all of which expressed EGFR, were felt to show EGFR gene amplification using a modification of the differential polymerase chain reaction on archival, formalin-fixed, paraffin-embedded tissue.	Paraffin	190-198	epidermal growth factor receptor	Homo sapiens	70-74
8089905-2	1994	Immunohistochemical localization of estrogen receptor on frozen/paraffin section was scored in a semi-quantitative fashion incorporating both the intensity and the distribution of specific staining.	Paraffin	64-72	estrogen receptor 1	Homo sapiens	36-53
7808790-3	1994	At present, our aim was, firstly, to see which were the best technical conditions for detection of p53 in the available paraffin-embedded tumor specimens, using several antibodies, specific for various epitopes; secondly, to investigate if some relation might exist between this expression and the histological features of these tumors.	Paraffin	120-128	tumor protein p53	Homo sapiens	99-102
8012775-2	1994	PATIENTS AND METHODS: The immunohistochemical status of the p53 protein in 28 pT1 primary bladder cancers was determined on frozen tissue and archival paraffin block sections using three primary antibodies (CM-1, PAB1801 and D07).	Paraffin	151-159	tumor protein p53	Homo sapiens	60-63
7915095-0	1994	Immunohistochemical studies on c-erbB-2 oncoprotein expression in paraffin embedded tissues in invasive and non-invasive human breast lesions.	Paraffin	66-74	erb-b2 receptor tyrosine kinase 2	Homo sapiens	31-39
8012776-4	1994	p53 expression was determined by immuno-histochemistry on paraffin embedded sections and flow cytometry was performed on cell suspensions derived from the same blocks.	Paraffin	58-66	tumor protein p53	Homo sapiens	0-3
11578406-1	1994	The expression of c-erbB-2 oncogene has been studied in 74 formalin fixed paraffin embedded invasive epithelial ovarian malignancies using a monoclonal c-erbB-2 protein antibody.	Paraffin	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
7909490-4	1994	METHODS: The immunostaining for HER-2/neu oncoprotein was performed on formaldehyde-solution-fixed, paraffin-embedded sections of 888 node-positive breast cancers resected between 1980 and 1986 and for which a follow-up of 2.5-10.5 years was available.	Paraffin	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-41
7520582-1	1994	Incidence of delta F508, a severe mutation of the CFTR gene is found to be 36.3% in paraffin block cystic fibrosis liver tissues.	Paraffin	84-92	CF transmembrane conductance regulator	Homo sapiens	50-54
8043159-9	1994	Since p53 (PAb 1801) expression can withstand formalin fixation and pepsin treatment of paraffin-embedded tissues, flow cytometric analysis of archival specimens is feasible, and clinical correlations such as these may be carried out in retrospective studies of other tumors.	Paraffin	88-96	tumor protein p53	Homo sapiens	6-9
8133533-4	1994	METHODS: The expression of Bcl-2 and p53 was detected by immunohistochemistry on paraffin-embedded sections from 283 node-negative resectable breast cancers treated with local-regional therapy alone until relapse.	Paraffin	81-89	BCL2 apoptosis regulator	Homo sapiens	27-32
8133533-4	1994	METHODS: The expression of Bcl-2 and p53 was detected by immunohistochemistry on paraffin-embedded sections from 283 node-negative resectable breast cancers treated with local-regional therapy alone until relapse.	Paraffin	81-89	tumor protein p53	Homo sapiens	37-40
7909221-5	1994	Positive staining for both p53 and HER-2/neu in paraffin-embedded tissues indicates an underlying genetic abnormality: point mutations in the p53 gene and amplification of the HER-2/neu gene.	Paraffin	48-56	tumor protein p53	Homo sapiens	27-30
7909221-5	1994	Positive staining for both p53 and HER-2/neu in paraffin-embedded tissues indicates an underlying genetic abnormality: point mutations in the p53 gene and amplification of the HER-2/neu gene.	Paraffin	48-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-44
7907940-4	1994	Overexpression of c-erbB-2 oncoprotein was studied by immunohistochemical alkaline phosphatase-antialkaline phosphatase staining of formalin fixed, paraffin embedded tissue sections of the primary tumor.	Paraffin	148-156	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
7909221-5	1994	Positive staining for both p53 and HER-2/neu in paraffin-embedded tissues indicates an underlying genetic abnormality: point mutations in the p53 gene and amplification of the HER-2/neu gene.	Paraffin	48-56	tumor protein p53	Homo sapiens	142-145
7909221-5	1994	Positive staining for both p53 and HER-2/neu in paraffin-embedded tissues indicates an underlying genetic abnormality: point mutations in the p53 gene and amplification of the HER-2/neu gene.	Paraffin	48-56	erb-b2 receptor tyrosine kinase 2	Homo sapiens	176-185
8028481-2	1994	Four additional members of the odorant receptor family were cloned from mouse olfactory mucosa and in situ hybridization was performed with paraffin-embedded tissue using digoxigenin labelled, non-radioactive antisense RNA probes for these individual receptor genes.	Paraffin	140-148	olfactory receptor family 6 subfamily F member 2	Mus musculus	31-47
8192247-5	1994	Standard immunoperoxidase methods were used to identify type IV collagen, laminin and fibronectin in paraffin sections.	Paraffin	101-109	fibronectin 1	Homo sapiens	86-97
7909307-0	1994	c-erbB-2 amplification in breast cancer: detection in formalin-fixed, paraffin-embedded tissue by in situ hybridization.	Paraffin	70-78	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
7511998-0	1994	Measuring c-erbB-2 oncogene amplification in fresh and paraffin-embedded tumors by competitive polymerase chain reaction.	Paraffin	55-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	10-18
7511998-4	1994	Using this procedure, we measured c-erbB-2 amplification in breast and bladder carcinomas in both fresh tumor tissues and paraffin-embedded tissue samples and assessed the precision, sensitivity, and accuracy of the assay.	Paraffin	122-130	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-42
7909307-1	1994	We describe a sensitive and practical in situ hybridization method, using a digoxigenin-labeled probe, for the detection of c-erbB-2 amplification in breast cancer in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	183-191	erb-b2 receptor tyrosine kinase 2	Homo sapiens	124-132
8207615-1	1994	Using a panel of antibodies to carcinoembryonic antigen (CEA), in paraffin-processed biopsy material patchy, predominantly membranous positivity was seen on tumour cells in 70 per cent of cases of superficial spreading melanoma, 60 per cent of nodular melanomas, and 75 per cent of secondary deposits studied with unabsorbed polyclonal anti-CEA only.	Paraffin	66-74	CEA cell adhesion molecule 3	Homo sapiens	31-55
8207615-1	1994	Using a panel of antibodies to carcinoembryonic antigen (CEA), in paraffin-processed biopsy material patchy, predominantly membranous positivity was seen on tumour cells in 70 per cent of cases of superficial spreading melanoma, 60 per cent of nodular melanomas, and 75 per cent of secondary deposits studied with unabsorbed polyclonal anti-CEA only.	Paraffin	66-74	CEA cell adhesion molecule 3	Homo sapiens	57-60
8207615-1	1994	Using a panel of antibodies to carcinoembryonic antigen (CEA), in paraffin-processed biopsy material patchy, predominantly membranous positivity was seen on tumour cells in 70 per cent of cases of superficial spreading melanoma, 60 per cent of nodular melanomas, and 75 per cent of secondary deposits studied with unabsorbed polyclonal anti-CEA only.	Paraffin	66-74	CEA cell adhesion molecule 3	Homo sapiens	341-344
8156496-3	1994	METHODS: The status of the p53 gene was studied by immunohistochemistry of formalin-fixed paraffin-embedded biopsy samples from 72 patients with atypical endometrial hyperplasia or endometrioid carcinoma who underwent hysterectomy immediately after biopsy and from 5 patients with benign endometria.	Paraffin	90-98	tumor protein p53	Homo sapiens	27-30
8058713-0	1994	Androgen receptor immunohistochemistry on paraffin-embedded tissue.	Paraffin	42-50	androgen receptor	Homo sapiens	0-17
8195931-3	1994	BCL-2 protein was detected in all the 46 formalin-fixed, paraffin-embedded samples from 34 patients representing all clinical stages and sites of involvement.	Paraffin	57-65	BCL2 apoptosis regulator	Homo sapiens	0-5
8163696-1	1994	AIMS: (i) To assess the validity of an immunocytochemical technique for detecting pS2 protein in paraffin wax embedded tissue; (ii) to provide further data on the relation between pS2 protein and oestrogen receptor (ER) and progesterone receptor (PgR).	Paraffin	97-109	taste 2 receptor member 64 pseudogene	Homo sapiens	82-85
8163696-10	1994	This provides strong support for using immunohistochemistry for pS2 in paraffin wax embedded tissue.	Paraffin	71-83	taste 2 receptor member 64 pseudogene	Homo sapiens	64-67
8162251-3	1994	We have developed a method utilizing polymerase chain reaction (PCR) for the direct analysis of p53 mutation by single-strand conformation polymorphism (SSCP) and by direct DNA sequencing of the p53 gene using a single 10-microns paraffin-embedded tissue section.	Paraffin	230-238	tumor protein p53	Homo sapiens	195-198
8162251-4	1994	We applied this method to screen for p53 gene mutations in exons 5-8 in human gliomas utilizing paraffin-embedded tissues.	Paraffin	96-104	tumor protein p53	Homo sapiens	37-40
8162254-7	1994	Paraffin sections of some adenomas that were negative for CgA protein had detectable CgA mRNA by in situ hybridization analysis.	Paraffin	0-8	chromogranin A	Homo sapiens	58-61
8162254-7	1994	Paraffin sections of some adenomas that were negative for CgA protein had detectable CgA mRNA by in situ hybridization analysis.	Paraffin	0-8	chromogranin A	Homo sapiens	85-88
8006643-8	1994	These data confirm 1) the feasibility of detecting HCV RNA in formalin-fixed, paraffin-embedded tissue from patients with chronic HCV infection, 2) show that sustained response to IFN is associated with loss of liver HCV RNA at the end of IFN therapy, and 3) offer an explanation for recurrence in patients who relapse.	Paraffin	78-86	interferon alpha 1	Homo sapiens	180-183
7508682-0	1994	New immunohistochemical "sandwich" staining method for mdr1 P-glycoprotein detection with JSB-1 monoclonal antibody in formalin-fixed, paraffin-embedded human tissues.	Paraffin	135-143	ATP binding cassette subfamily B member 1	Homo sapiens	60-74
21607363-0	1994	Immunohistochemical expression of p53 paraffin sections from colon-cancer specimens - comparison between 2 new monoclonal-antibodies.	Paraffin	38-46	tumor protein p53	Homo sapiens	34-37
21607363-2	1994	We examined the immunohistochemical expression of p53 in 40 paraffin-embedded samples obtained from colon carcinomas using the two new MAbs DO-1 and DO-7.	Paraffin	60-68	tumor protein p53	Homo sapiens	50-53
8116572-1	1994	The authors had previously reported that the accumulation of p53 is clearly demonstrable in microwave-fixed, paraffin-embedded sections of colorectal carcinomas.	Paraffin	109-117	tumor protein p53	Homo sapiens	61-64
7508682-1	1994	We have developed a new immunoperoxidase "sandwich" staining method for amplified detection of P-glycoprotein (Pgp) that is suitable for use on formalin-fixed, paraffin-embedded (conventional) tissue sections.	Paraffin	160-168	ATP binding cassette subfamily B member 1	Homo sapiens	95-109
7508682-1	1994	We have developed a new immunoperoxidase "sandwich" staining method for amplified detection of P-glycoprotein (Pgp) that is suitable for use on formalin-fixed, paraffin-embedded (conventional) tissue sections.	Paraffin	160-168	ATP binding cassette subfamily B member 1	Homo sapiens	111-114
7508682-11	1994	This new immunoperoxidase sandwich staining method using JSB-1 now allows reliable Pgp detection in sections of formalin-fixed, paraffin-embedded (archived) surgical specimens and small biopsy materials commonly used for diagnostic purposes.	Paraffin	128-136	ATP binding cassette subfamily B member 1	Homo sapiens	83-86
8311654-4	1994	Positive nuclear p53 immunoreactivity was detected in 37% of paraffin-embedded primary tumors (21.8% in the Japanese group, 52.6% in the American group) and in 50% of xenotransplanted carcinoma cell lines.	Paraffin	61-69	tumor protein p53	Homo sapiens	17-20
8008749-1	1994	p53 expression in formalin-fixed, paraffin-embedded archival specimens of intrahepatic cholangiocarcinoma: retrieval of p53 antigenicity by microwave oven heating of tissue sections.	Paraffin	34-42	tumor protein p53	Homo sapiens	0-3
7905364-1	1994	BACKGROUND: A polyclonal antihuman c-erbB-2 oncoprotein antibody recognized c-erbB-2 oncoprotein in routinely formaldehyde-fixed, paraffin-embedded specimens.	Paraffin	130-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	35-43
7905364-1	1994	BACKGROUND: A polyclonal antihuman c-erbB-2 oncoprotein antibody recognized c-erbB-2 oncoprotein in routinely formaldehyde-fixed, paraffin-embedded specimens.	Paraffin	130-138	erb-b2 receptor tyrosine kinase 2	Homo sapiens	76-84
21566945-1	1994	Tumoral Carcino Embryonic Antigen (CEA) and Tissue Polypeptide Antigen (TPA) expression was investigated by immunoperoxidase technique on paraffin embedded tissues of 191 patients with infiltrating breast cancer and negative axillary nodes.	Paraffin	138-146	plasminogen activator, tissue type	Homo sapiens	72-75
7907612-5	1994	Applying these fixatives to samples from a further 16 gastrectomy specimens, strong membrane staining of c-erbB-2 protein was found in the tumour in eight of 16 cases (50%) using paraffin wax sections, and staining was stronger in the better differentiated carcinomas.	Paraffin	179-191	erb-b2 receptor tyrosine kinase 2	Homo sapiens	105-113
7907612-7	1994	CONCLUSIONS: These results indicate that fixation and paraffin wax embedding affect the results of immunohistochemical demonstration of c-erbB-2 in gastric cancer.	Paraffin	54-66	erb-b2 receptor tyrosine kinase 2	Homo sapiens	136-144
8008749-10	1994	These results shows that a pretreatment of tissue sections by microwave oven heating is a very good method for demonstrating p53 protein in formalin-fixed, paraffin-embedded archival materials and that DO-7, BP53-12, and CM1 are useful antibodies for detection of p53 in formalin-fixed, paraffin-embedded archival materials.	Paraffin	156-164	tumor protein p53	Homo sapiens	125-128
8008749-4	1994	We investigated expression of p53 in formalin-fixed, paraffin-embedded archival specimens of 40 CCs (22 autopsy cases and 18 surgical cases) by immunohistochemistry using four antibodies (PAb1801, DO-7, BP53-12, CM1).	Paraffin	53-61	tumor protein p53	Homo sapiens	30-33
8032216-5	1994	We found point mutations in 25% (9 of 36) of cultured melanomas and 0% in 34 fresh melanoma biopsies; however, increased p53 expression was found in 42% of paraffin-embedded melanoma specimens and 7% of benign lesions.	Paraffin	156-164	tumor protein p53	Homo sapiens	121-124
8111580-7	1994	Immunohistochemical staining of formalin-fixed, paraffin-embedded tumor samples detected iCT in two of four tumors from patients whose tumor cell lines had CT mRNA by RPA and iCT by RIA, but in none of six whose tumor cell lines had undetectable CT mRNA.	Paraffin	48-56	calcitonin related polypeptide alpha	Homo sapiens	90-92
7903962-2	1994	METHODS AND MATERIALS: Immunohistochemical analysis for c-erb B-2 over-expression was retrospectively performed on 107 paraffin-embedded specimens of women with Stage I or II breast cancer entered in a randomized trial.	Paraffin	119-127	erb-b2 receptor tyrosine kinase 2	Homo sapiens	56-65
7904895-1	1994	BACKGROUND: Expression and cellular localization of the multidrug resistance gene product P-glycoprotein, which plays an important role in multidrug resistance to cancer chemotherapy, were immunohistochemically studied in paraffin sections from 55 patients with primary liver carcinoma.	Paraffin	222-230	ATP binding cassette subfamily B member 1	Homo sapiens	90-104
8140894-4	1994	We have used immunocytochemistry for the beta-amyloid precursor protein (beta APP) as a marker for axonal injury in formalin-fixed, paraffin-embedded sections of human brain.	Paraffin	132-140	amyloid beta precursor protein	Homo sapiens	41-71
8140894-4	1994	We have used immunocytochemistry for the beta-amyloid precursor protein (beta APP) as a marker for axonal injury in formalin-fixed, paraffin-embedded sections of human brain.	Paraffin	132-140	amyloid beta precursor protein	Homo sapiens	73-81
8279627-8	1994	Five demonstrated light-chain restriction; one was an immunoglobulin-negative B-cell neoplasm; and six, in which only formalin-fixed, paraffin-embedded tissue was available, demonstrated overexpression of the bcl-2 protein.	Paraffin	134-142	BCL2 apoptosis regulator	Homo sapiens	209-214
8293402-5	1994	Assessment of EGFR overexpression was done at the protein level by the use of an anti-EGFR polyclonal antibody that reacts with the cytoplasmic membrane glycoprotein receptor in paraffin-embedded tissues.	Paraffin	178-186	epidermal growth factor receptor	Homo sapiens	14-18
8293402-5	1994	Assessment of EGFR overexpression was done at the protein level by the use of an anti-EGFR polyclonal antibody that reacts with the cytoplasmic membrane glycoprotein receptor in paraffin-embedded tissues.	Paraffin	178-186	epidermal growth factor receptor	Homo sapiens	86-90
8293408-5	1994	Immunostaining for mutant p53 proteins was performed on tissues fixed in formaldehyde solution and embedded in paraffin; the tissues were from these 44 astrocytomas and another 103 astrocytomas obtained from archival material.	Paraffin	111-119	tumor protein p53	Homo sapiens	26-29
8308286-2	1994	In this study we have extended NISH technology for mRNA detection to include the use of digoxigenin-labelled riboprobes to localise low abundance mRNA for interleukin-4 in paraffin embedded material (from active inflammatory bowel disease).	Paraffin	172-180	interleukin 4	Homo sapiens	155-168
7917539-1	1994	In the present study, pS2 protein expression in pulmonary adenocarcinoma was investigated on paraffin-embedded sections obtained from 170 patients.	Paraffin	93-101	taste 2 receptor member 64 pseudogene	Homo sapiens	22-25
7506924-1	1994	The availability of antibodies which recognise p53 protein in paraffin-embedded tissue has created the opportunity to use immunohistochemistry to study the expression of p53 in a wide variety of clinical material.	Paraffin	62-70	tumor protein p53	Homo sapiens	47-50
7719291-0	1994	p53 mutant gene expression in paraffin embedded and fresh frozen tissue of different urogenital tumors.	Paraffin	30-38	tumor protein p53	Homo sapiens	0-3
7509767-1	1994	Possible changes in the expression of the HNK-1 carbohydrate epitope in the inner connective tissue layer of the human ciliary body, located between the ciliary epithelium and muscle, was studied using 2 formalin-fixed, paraffin-embedded eyes with exfoliation syndrome, 33 eyes with different types of glaucoma, and 21 morphologically normal control eyes.	Paraffin	220-228	beta-1,3-glucuronyltransferase 1	Homo sapiens	42-47
7843462-1	1994	Distribution of S-100 protein in porcine ovaries was revealed by an application of polyclonal antibodies against S-100 protein and PAP universal kit to formalin-fixed, paraffin-embedded tissues.	Paraffin	168-176	S100 calcium binding protein A1	Homo sapiens	16-21
8144145-1	1994	The expression of BCL-2 protein was analysed in 10 fetal and 45 infant breast specimens by immunocytochemical staining of methacarn-fixed, paraffin-embedded tissue.	Paraffin	139-147	BCL2 apoptosis regulator	Homo sapiens	18-23
7523560-5	1994	In a pilot experiment, RNAs isolated from formalin-fixed (FF) and formalin-fixed and paraffin-embedded (FFPE) canine prostatic tissues were shown to be of sufficient quality to permit amplification of KGF mRNA by RT-PCR.	Paraffin	85-93	fibroblast growth factor 7	Canis lupus familiaris	201-204
8165016-0	1994	Paraffin section p53 protein immunohistochemistry in neuroectodermal tumors.	Paraffin	0-8	tumor protein p53	Homo sapiens	17-20
7931822-1	1994	Immunocytochemical detection of p53 protein products in paraffin sections is possible with a number of antisera, monoclonal and polyclonal.	Paraffin	56-64	tumor protein p53	Homo sapiens	32-35
7816281-4	1994	An Il-1 beta cDNA probe was 32P-labelled by random primers and hybridized to paraffin-embedded tissue sections after de-waxing.	Paraffin	77-85	interleukin 1 beta	Homo sapiens	3-12
7909153-9	1994	This study demonstrates the use of paraffin sections in the analysis of p53 alterations in neoplasia.	Paraffin	35-43	tumor protein p53	Homo sapiens	72-75
7903441-1	1994	Expression of the c-erbB-2 oncogene protein was investigated by immunohistochemistry in 110 paraffin-embedded blocks of primary breast cancer.	Paraffin	92-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
8186888-0	1994	Polymerase chain reaction-single strand conformation polymorphism analysis of the p53 gene in paraffin-embedded surgical material from human renal cell carcinomas.	Paraffin	94-102	tumor protein p53	Homo sapiens	82-85
7902202-4	1993	METHODS: Immunohistochemical reactivity to c-erbB-2 protein was examined in formalin-fixed, paraffin-embedded tissue sections from patients with gastric cancer.	Paraffin	92-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	43-51
8252480-5	1993	METHODS: Tumor tissues of 156 patients with primary invasive breast cancer were analyzed immunohistochemically for the presence of p53 protein in paraffin-embedded material.	Paraffin	146-154	tumor protein p53	Homo sapiens	131-134
8253523-1	1993	We examined the expression of pS2 protein in 48 invasive ductal breast carcinomas with an extensive intraductal component, using immunohistochemical staining of paraffin-embedded sections.	Paraffin	161-169	taste 2 receptor member 64 pseudogene	Homo sapiens	30-33
8238731-3	1993	The goal of this study was to determine the frequency and relationship of p53 gene alterations and hepatitis B in formalin-fixed, paraffin-embedded HCCs resected in the United States.	Paraffin	130-138	tumor protein p53	Homo sapiens	74-77
7514077-0	1994	Preferential localization of c-kit product in tissue mast cells, basal cells of skin, epithelial cells of breast, small cell lung carcinoma and seminoma/dysgerminoma in human: immunohistochemical study on formalin-fixed, paraffin-embedded tissues.	Paraffin	221-229	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	29-34
8291686-1	1993	Endothelin-1 (ET-1) localization in bone cells and associated vascular endothelial cells in metaphyseal bone marrow of the rat femur was examined by a biotin-streptoavidin-horseradish peroxidase method in paraffin sections and by indirect immunogold techniques in post-embedded ultrathin sections.	Paraffin	205-213	endothelin 1	Rattus norvegicus	0-12
8158458-1	1993	The expression of the nuclear protein p53 in oligodendrogliomas was investigated by immunohistochemistry, using a monoclonal anti-p53 antibody (DO-7) on formalin-fixed, paraffin-embedded material in 84 histologically verified cases, and compared with the histopathological grade and survival.	Paraffin	169-177	tumor protein p53	Homo sapiens	38-41
7901994-13	1993	We conclude that the immunohistochemical detection of p53 nuclear accumulation in formalin-fixed, paraffin-embedded tissue is highly associated with mutations in the p53 gene; this association has now been demonstrated in a large number of tumors.	Paraffin	98-106	tumor protein p53	Homo sapiens	54-57
7901994-13	1993	We conclude that the immunohistochemical detection of p53 nuclear accumulation in formalin-fixed, paraffin-embedded tissue is highly associated with mutations in the p53 gene; this association has now been demonstrated in a large number of tumors.	Paraffin	98-106	tumor protein p53	Homo sapiens	166-169
8314240-1	1993	12E7 is a monoclonal antibody to the MIC2 gene product and can be applied to formalin-fixed, paraffin-embedded tissue.	Paraffin	93-101	CD99 molecule (Xg blood group)	Homo sapiens	37-41
8238244-4	1993	Immunostaining for BCL-2 on paraffin material was performed using microwave treatment of tissue sections before the application of the primary monoclonal antibody.	Paraffin	28-36	BCL2 apoptosis regulator	Homo sapiens	19-24
7692889-0	1993	Retrieval of p53 protein in paraffin-embedded head and neck tumor tissues.	Paraffin	28-36	tumor protein p53	Homo sapiens	13-16
7692889-1	1993	OBJECTIVES: To improve the detection of p53 protein in formalin-fixed, paraffin-embedded head and neck tumor tissues.	Paraffin	71-79	tumor protein p53	Homo sapiens	40-43
7692889-8	1993	RESULTS: An antigen retrieval method facilitated the unmasking of previously inaccessible p53 antigenic determinants in formalin-fixed, paraffin-embedded tissues.	Paraffin	136-144	tumor protein p53	Homo sapiens	90-93
7692889-11	1993	CONCLUSIONS: Antigen retrieval method in formalin-fixed, paraffin-embedded tissue demonstrated a significant increase in p53 immunostaining.	Paraffin	57-65	tumor protein p53	Homo sapiens	121-124
21573436-4	1993	Expression of p53 protein and P-170 glycoprotein was detected by immunohistochemistry using the PAb1801 and C219 monoclonal antibody respectively, on sections from paraffin-embedded tumor biopsies.	Paraffin	164-172	tumor protein p53	Homo sapiens	14-17
8244314-9	1993	These results demonstrate the utility of the commercially obtained bcl-2 antibody in distinguishing FL from FH in B5-fixed, paraffin-embedded tissue sections.	Paraffin	124-132	BCL2 apoptosis regulator	Homo sapiens	67-72
8244324-3	1993	We describe the localization of p53 protein in association with HPV in paraffin sections of a spectrum of benign, dysplastic, and malignant anogenital squamous epithelia using immunohistochemical and in situ hybridization techniques.	Paraffin	71-79	tumor protein p53	Homo sapiens	32-35
7905629-0	1993	Assessment of c-erbB-2 amplification by immunohistochemistry in paraffin-embedded breast cancer.	Paraffin	64-72	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-22
7691930-0	1993	Antigen retrieval technique utilizing citrate buffer or urea solution for immunohistochemical demonstration of androgen receptor in formalin-fixed paraffin sections.	Paraffin	147-155	androgen receptor	Homo sapiens	111-128
7691930-1	1993	We developed a staining protocol for demonstration of androgen receptor (AR) in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	96-104	androgen receptor	Homo sapiens	54-71
7691930-1	1993	We developed a staining protocol for demonstration of androgen receptor (AR) in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	96-104	androgen receptor	Homo sapiens	73-75
8104689-8	1993	Importantly, a series of molecularly characterized breast cancer specimens were used to confirm that the antibody used was of sufficient sensitivity and specificity to identify those cancers overexpressing the HER-2/neu protein in this formalin-fixed, paraffin-embedded tissue cohort.	Paraffin	252-260	erb-b2 receptor tyrosine kinase 2	Homo sapiens	210-219
7901825-1	1993	c-erbB-2 gene amplification was examined by slot blot hybridization using DNAs extracted from formalin-fixed and paraffin-embedded tissues of primary gastric carcinomas.	Paraffin	113-121	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
8237246-0	1993	Analysis of the Gs alpha gene in growth hormone-secreting pituitary adenomas by the polymerase chain reaction-direct sequencing method using paraffin-embedded tissues.	Paraffin	141-149	GNAS complex locus	Homo sapiens	16-24
8402645-13	1993	We conclude that analysis of methylation in the androgen receptor gene should allow study of clonality in most formalin-fixed, paraffin-embedded tissue specimens from women, including small preneoplastic lesions or rare conditions for which sufficient material is not available for analysis by other techniques.	Paraffin	127-135	androgen receptor	Homo sapiens	48-65
8397058-3	1993	RESULTS: C-erbB-2 protein was located on the cell membrane of cancer cells in formalin-fixed, paraffin-embedded sections.	Paraffin	94-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-17
7508232-3	1993	Using streptavidin-biotin complex method, p53 was identified in 33% of dysplastic squamous lesions, 50% of squamous cell carcinomas (SCCs) and 36% of basal cell carcinomas (BCCs) on frozen section, whereas 25% of dysplastic squamous lesions, 40% of SCCs, and 32% of BCCs showed p53 positivity on paraffin-embedded sections.	Paraffin	296-304	tumor protein p53	Homo sapiens	42-45
8232185-1	1993	The localization of Cu/Zn and Mn superoxide dismutase (SOD), which catalyzes the dismutation of superoxide radicals (O2-) to O2 and H2O2, in various thyroid disorders was studied by an immunohistochemical technique in 20% formalin fixed paraffin embedded thin sections using anti-human Cu/Zn and Mn-SOD antibodies.	Paraffin	237-245	superoxide dismutase 1	Homo sapiens	55-58
8283348-6	1993	Overexpression of the p53 protein was found by immunostaining of sections from formalin-fixed, paraffin-embedded material in 55 per cent (51/92) of the tumours.	Paraffin	95-103	tumor protein p53	Homo sapiens	22-25
8283352-0	1993	Immunocytochemical p53 detection by microwave oven heating of routinely formalin-fixed paraffin sections.	Paraffin	87-95	tumor protein p53	Homo sapiens	19-22
8363836-0	1993	A method for PCR sequencing of the p53 gene from a single 10-microns frozen or paraffin-embedded tissue section.	Paraffin	79-87	tumor protein p53	Homo sapiens	35-38
8248107-1	1993	p53 overexpression was studied immunohistochemically in paraffin-embedded bone marrow biopsies using a recently described technique for antigen retrieval based on microwave oven heating of paraffin sections.	Paraffin	56-64	tumor protein p53	Homo sapiens	0-3
8248107-1	1993	p53 overexpression was studied immunohistochemically in paraffin-embedded bone marrow biopsies using a recently described technique for antigen retrieval based on microwave oven heating of paraffin sections.	Paraffin	189-197	tumor protein p53	Homo sapiens	0-3
8347496-1	1993	The expression of p53 protein was immunohistochemically studied in formalin-fixed paraffin-embedded biopsy specimens of 203 colorectal carcinomas by use of a monoclonal antibody specific for the p53 protein.	Paraffin	82-90	tumor protein p53	Homo sapiens	18-21
8371594-0	1993	Bcl-2 protein in centrocytic lymphoma; a paraffin section study.	Paraffin	41-49	BCL2 apoptosis regulator	Homo sapiens	0-5
8101229-5	1993	Using an immunoperoxidase technique, we stained archival formalin-fixed, paraffin-embedded tissue sections with a monoclonal antibody to the 185-kilodalton protein product (p185) of the HER-2/neu gene.	Paraffin	73-81	erb-b2 receptor tyrosine kinase 2	Homo sapiens	186-195
8112175-1	1993	Expression of P53 protein was detected immunohistochemically in formalin-fixed, paraffin-embedded tissues from 67 patients with bladder carcinoma and 6 normal bladder controls.	Paraffin	80-88	tumor protein p53	Homo sapiens	14-17
8218573-4	1993	Gold colloid of 5 nm diameter particle size prepared with white phosphorus minimized nonspecific background labeling of beta-casein in paraffin embedded sections of the mammary epithelium of pregnant mice.	Paraffin	135-143	casein beta	Mus musculus	120-131
8265245-3	1993	Accurate and reliable determination of pS2 status in breast cancer can be made on the basis of immunohistochemistry using formalin fixed paraffin embedded sections.	Paraffin	137-145	taste 2 receptor member 64 pseudogene	Homo sapiens	39-42
8415589-1	1993	The p53 gene was examined in a series of formalin-fixed paraffin-embedded astrocytic neoplasms of various types by polymerase chain reaction (PCR), single-strand conformation polymorphism analysis (SSCP), and direct sequencing of amplified DNA.	Paraffin	56-64	tumor protein p53	Homo sapiens	4-7
8099533-6	1993	METHODS: The expression of c-erbB-2 protein was immunohistochemically investigated in the formaldehyde-fixed, paraffin-embedded tissues of 17 cases of IMHN, and 14 cases of pancreatic ductal cell carcinoma (8 cases with lymph node metastasis), using polyclonal and monoclonal c-erbB-2(p185) antibodies by the avidin-biotin method.	Paraffin	110-118	erb-b2 receptor tyrosine kinase 2	Homo sapiens	27-35
8468448-0	1993	Immunocytochemical localization of androgen receptor with polyclonal antibody in paraffin-embedded human tissues.	Paraffin	81-89	androgen receptor	Homo sapiens	35-52
8496982-5	1993	METHODS: Expression of mutant p53 protein was detected by an immunohistochemical technique using a 1:50 dilution of PAb1801 monoclonal antibody on paraffin-embedded tumor specimens obtained from 256 axillary lymph node-negative breast cancer patients, with long-term follow-up (median, 72 months).	Paraffin	147-155	tumor protein p53	Homo sapiens	30-33
32370448-2	1993	In the present study, p53 immunoreactivity was investigated in formalin-fixed, paraffin-embedded tissues from human and animal pituitary tumors, using the avidin-biotin-peroxidase complex technique.	Paraffin	79-87	tumor protein p53	Homo sapiens	22-25
8392521-3	1993	METHODS: The presence and localisation of the p53 protein in formalin fixed, paraffin wax embedded specimens of anal squamous epithelium (normal and neoplastic) was examined using immunohistochemical staining with a panel of two monoclonal antibodies (DO-1, DO-7) and one polyclonal antibody (CM-1).	Paraffin	77-89	tumor protein p53	Homo sapiens	46-49
7684193-2	1993	Immunohistochemical staining with a monoclonal antibody (DO-7) and a polyclonal antibody (CM-1) to p53 protein (both wild type and mutant) on formalin-fixed paraffin sections showed a strong correlation with malignancy grade.	Paraffin	157-165	tumor protein p53	Homo sapiens	99-102
8468448-1	1993	We investigated the immunohistochemical localization of androgen receptor (AR) using a polyclonal antibody for 55 KD recombinant human AR in human tissues fixed with 4% paraformaldehyde solution and embedded in paraffin.	Paraffin	211-219	androgen receptor	Homo sapiens	56-73
8468448-1	1993	We investigated the immunohistochemical localization of androgen receptor (AR) using a polyclonal antibody for 55 KD recombinant human AR in human tissues fixed with 4% paraformaldehyde solution and embedded in paraffin.	Paraffin	211-219	androgen receptor	Homo sapiens	75-77
7687354-1	1993	Although over-expression of the C-erbB-2 oncogene product can be detected on formalin-fixed, paraffin-embedded sections from tumours of the human breast, fixation results in a considerable loss of immunostaining for this protein.	Paraffin	93-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	32-40
7688167-1	1993	Expression of p53 protein was examined in 67 cases of primary transitional cell carcinoma of the bladder and 6 normal controls using an immunohistochemical method on paraffin sections.	Paraffin	166-174	tumor protein p53	Homo sapiens	14-17
7682766-2	1993	Expression of the epithelial-specific adhesion molecule E-cadherin has been assessed in paraffin-embedded tissue from a series of 72 colorectal carcinomas.	Paraffin	88-96	cadherin 1	Homo sapiens	56-66
8385977-1	1993	The expression of pS2 was examined histochemically in paraffin sections taken from biopsy material from patients diagnosed with ductal carcinoma in situ (DCIS).	Paraffin	54-62	taste 2 receptor member 64 pseudogene	Homo sapiens	18-21
8489284-2	1993	For assessing malignant potential in diploid colorectal cancer, flow cytometric analysis of S-phase fraction (SPF) was investigated using paraffin-embedded materials from 79 carcinoma patients who had been treated from 1971 to 1989.	Paraffin	138-146	SEC14 like lipid binding 2	Homo sapiens	110-113
7681857-0	1993	Expression of the human progenitor cell antigen CD34 (HPCA-1) distinguishes dermatofibrosarcoma protuberans from fibrous histiocytoma in formalin-fixed, paraffin-embedded tissue.	Paraffin	153-161	CD34 molecule	Homo sapiens	48-52
7681857-3	1993	OBJECTIVE: This study is aimed at the introduction of a monoclonal antibody (anti-human progenitor cell antigen-1; anti-CD34) that distinguishes between DFSP and FH in formalin-fixed, paraffin-embedded tissue.	Paraffin	184-192	CD34 molecule	Homo sapiens	120-124
7681857-6	1993	CONCLUSION: CD34 immunostaining of paraffin-embedded specimens may be useful in differentiating between DFSP and FH.	Paraffin	35-43	CD34 molecule	Homo sapiens	12-16
7684758-1	1993	We describe a simple immunohistochemical method for simultaneous demonstration of insulin, glucagon, somatostatin, and pancreatic polypeptide cells of the Langerhans islet in routinely fixed paraffin-embedded human and Syrian hamster pancreases.	Paraffin	191-199	insulin	Homo sapiens	82-89
8452928-4	1993	Immunohistochemical techniques were used to localize TP2 in paraffin-embedded testis sections from mice and rats.	Paraffin	60-68	transition protein 2	Mus musculus	53-56
8384406-1	1993	Striking differences were found between different histological types of breast cancer when 263 invasive breast carcinomas were tested for nuclear p53 accumulation in formaldehyde-fixed paraffin sections.	Paraffin	185-193	tumor protein p53	Homo sapiens	146-149
8384408-1	1993	The spectrum of p53 gene mutations was determined in formalin-fixed, paraffin-embedded samples of small-cell lung cancer derived from 28 patients.	Paraffin	69-77	tumor protein p53	Homo sapiens	16-19
8104720-1	1993	A monoclonal antibody, NCL-CB11, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunohistochemically in a retrospective study of formalin-fixed paraffin embedded breast neoplasm biopsies.	Paraffin	199-207	erb-b2 receptor tyrosine kinase 2	Homo sapiens	103-111
8483890-0	1993	p53 protein immunostaining in routinely processed paraffin-embedded sections.	Paraffin	50-58	tumor protein p53	Homo sapiens	0-3
8094977-2	1993	The expression of c-erbB-2 oncoprotein was determined on formalin-fixed paraffin-embedded tissue, using a monoclonal anti-c-erbB-2 antibody by the avidin-biotin immunoperoxidase method.	Paraffin	72-80	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-26
8439966-0	1993	A rapid colorimetric in situ messenger RNA hybridization technique for analysis of epidermal growth factor receptor in paraffin-embedded surgical specimens of human colon carcinomas.	Paraffin	119-127	epidermal growth factor receptor	Homo sapiens	83-115
8439966-1	1993	We have developed a rapid colorimetric in situ mRNA hybridization procedure to analyze epidermal growth factor receptor (EGF-R) transcripts in paraffin-embedded surgical specimens of human colon carcinomas.	Paraffin	143-151	epidermal growth factor receptor	Homo sapiens	87-119
8439966-1	1993	We have developed a rapid colorimetric in situ mRNA hybridization procedure to analyze epidermal growth factor receptor (EGF-R) transcripts in paraffin-embedded surgical specimens of human colon carcinomas.	Paraffin	143-151	epidermal growth factor receptor	Homo sapiens	121-126
8439966-6	1993	In situ hybridization of paraffin-embedded sections of primary human colon carcinoma and metastases from liver and lymph node revealed cell-specific staining with EGF-R antisense oligonucleotide probes that correlated directly with Northern blot and immunohistochemistry analyses.	Paraffin	25-33	epidermal growth factor receptor	Homo sapiens	163-168
7682888-2	1993	In a case of endometrioid carcinoma of the prostate the expression of Leu7 and prostatic specific antigen (PSA) was studied immunohistochemically on paraffin sections.	Paraffin	149-157	beta-1,3-glucuronyltransferase 1	Homo sapiens	70-74
21573575-7	1993	In contrast to frozen sections, the pS2 positivity on paraffin sections could not be evaluated by image analysis system because of the background.	Paraffin	54-62	taste 2 receptor member 64 pseudogene	Homo sapiens	36-39
8483890-3	1993	We report a technique for immunostaining of the altered p53 protein in routinely processed paraffin-embedded tissue sections, comparing this method with a frozen-section immunostain method for concordance.	Paraffin	91-99	tumor protein p53	Homo sapiens	56-59
8321742-2	1993	Immunohistochemical study for epidermal growth factor (EGF) and epidermal growth factor receptor (EGFR) was performed on paraffin-embedded tissue specimens from 39 colorectal and 24 gastric carcinomas.	Paraffin	121-129	epidermal growth factor receptor	Homo sapiens	98-102
8483890-9	1993	We propose that this new paraffin-embedded section immunostaining method will be of value as a screening technique for the investigation of p53 mutations in archived human tumors.	Paraffin	25-33	tumor protein p53	Homo sapiens	140-143
8434637-0	1993	Detection of p53 overexpression in routinely paraffin-embedded tissue of human carcinomas using a novel target unmasking fluid.	Paraffin	45-53	tumor protein p53	Homo sapiens	13-16
8434637-1	1993	With the aid of a newly developed target unmasking fluid (TUF), p53 overexpression was visualized by immunohistochemistry on recent and archival paraffin-embedded tissue samples of colon, stomach, and pancreas neoplasms.	Paraffin	145-153	tumor protein p53	Homo sapiens	64-67
8093216-1	1993	An immunohistochemical study of the c-erbB-2 protein was conducted on formalin-fixed paraffin-embedded tissue sections from 136 primary gastric carcinomas and 50 metastatic lymph-node tumors obtained at gastrectomy.	Paraffin	85-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	36-44
8101139-3	1993	We used newly-developed PCR-RFLP technique to detect the point mutation of the 7th exon of p53 gene in fresh and paraffin embedded tissues of hepatocellular carcinoma in studying 40 cases.	Paraffin	113-121	tumor protein p53	Homo sapiens	91-94
7905303-1	1993	Immunohistochemical c-erbB-2 protein overexpression was detected in 34 of 124 (27.4%) paraffin-embedded breast cancer specimens.	Paraffin	86-94	erb-b2 receptor tyrosine kinase 2	Homo sapiens	20-28
8382897-6	1993	In this study, we stained paraffin sections from eight samples of gliosarcomas from seven patients with an antibody to p53.	Paraffin	26-34	tumor protein p53	Homo sapiens	119-122
7678023-5	1993	In the present study, we found that the epitopes of HRF20 were well preserved for immunohistochemistry even in acetone-fixed and paraffin-embedded tissues, as well as in frozen tissues that have been conventionally used for HRF20.	Paraffin	129-137	CD59 molecule (CD59 blood group)	Homo sapiens	52-57
8433213-0	1993	Immunohistochemical analysis of the p53 oncoprotein on paraffin sections using a series of novel monoclonal antibodies.	Paraffin	55-63	tumor protein p53	Homo sapiens	36-39
8433213-4	1993	Furthermore, at least three MAbs (Bp53-11, Bp53-12, and Bp53-28) proved to be reliable reagents for immunohistochemistry on paraffin-embedded specimens.	Paraffin	124-132	BP53	Homo sapiens	34-38
8433213-4	1993	Furthermore, at least three MAbs (Bp53-11, Bp53-12, and Bp53-28) proved to be reliable reagents for immunohistochemistry on paraffin-embedded specimens.	Paraffin	124-132	BP53	Homo sapiens	43-47
8433213-4	1993	Furthermore, at least three MAbs (Bp53-11, Bp53-12, and Bp53-28) proved to be reliable reagents for immunohistochemistry on paraffin-embedded specimens.	Paraffin	124-132	BP53	Homo sapiens	43-47
8097100-9	1993	The results show that immunohistochemical demonstration of c-erbB-2 oncoprotein overexpression in paraffin embedded archival material has no prognostic value over already established predictors in TCC.	Paraffin	98-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	59-67
8105839-1	1993	Competitive polymerase chain reaction (PCR) systems were developed for rapid and quantitative estimation of HER-2 (c-erbB-2) and INT-2 oncogene amplification in paraffin-embedded ovarian cancer tissue samples.	Paraffin	161-169	erb-b2 receptor tyrosine kinase 2	Homo sapiens	108-113
8318988-4	1993	Here we describe a simple technique for DNA isolation that permits mutational analysis of p53 from minimal amounts of paraffin-embedded archival tissue samples.	Paraffin	118-126	tumor protein p53	Homo sapiens	90-93
8449825-0	1993	bcl-2 gene rearrangement analysis of Japanese follicular lymphomas by polymerase chain reaction in formalin-fixed, paraffin-embedded tissue specimens.	Paraffin	115-123	BCL2 apoptosis regulator	Homo sapiens	0-5
8094884-1	1993	We studied the overexpression of c-erbB-2 protein in formalin-fixed, paraffin-embedded tissues from matched primary tumors and metastatic lymph nodes derived from each of 95 breast carcinoma patients.	Paraffin	69-77	erb-b2 receptor tyrosine kinase 2	Homo sapiens	33-41
8236825-0	1993	Epidermal growth factor receptor expression in squamous cell lung carcinomas: an immunohistochemical and gene analysis in formalin-fixed, paraffin-embedded material.	Paraffin	138-146	epidermal growth factor receptor	Homo sapiens	0-32
7694421-1	1993	The expression of involucrin, a structural component of the envelope of mature squamous epithelium, was studied in 166 paraffin-embedded breast carcinomas.	Paraffin	119-127	involucrin	Homo sapiens	18-28
8236825-5	1993	In addition, analysis of the EGFr gene was carried out by Southern blotting and DPCR on paraffin extracted DNA from the same carcinoma cases.	Paraffin	88-96	epidermal growth factor receptor	Homo sapiens	29-33
8506620-2	1993	Using a microwave oven heating method, we have detected over-expression of p53 in buffered-formalin fixed, paraffin-embedded sections of oesophageal carcinomas immunohistochemically and examined the relationship between the p53 over-expression and postoperative survival.	Paraffin	107-115	tumor protein p53	Homo sapiens	75-78
1484319-0	1992	p53 immunostaining in the distinction between benign and malignant mesothelial proliferations using formalin-fixed paraffin sections.	Paraffin	115-123	tumor protein p53	Homo sapiens	0-3
1487569-1	1992	A histochemical investigation of lectin-binding sites was carried out on formalin-fixed paraffin-embedded sections of 60 skin appendage tumors and adjacent normal skin appendages, using four different biotinylated lectins, peanut agglutinin (PNA), Dolichos biflorus agglutinin (DBA), soybean agglutinin (SBA), and Ulex europaeus agglutinin-1 (UEA-1), and avidin-biotin-horseradish peroxidase labeling.	Paraffin	88-96	LOW QUALITY PROTEIN: lectin	Glycine max	33-39
1484319-2	1992	The object of this study was to examine the frequency of immunohistochemically detectable p53 overexpression in routinely processed, paraffin-embedded tissue from pleural mesotheliomas and from pleura showing reactive mesothelial hyperplasia, using a polyclonal antibody to formalin-resistant p53 epitopes, and to consider the diagnostic utility of this antibody in the distinction between mesothelioma and reactive mesothelium in pleural biopsy specimens.	Paraffin	133-141	tumor protein p53	Homo sapiens	90-93
1484319-6	1992	In conclusion, this study suggests that p53 immunostaining can help to distinguish epithelial or biphasic mesothelioma from reactive mesothelial hyperplasia in formalin-fixed, paraffin-embedded pleural biopsy specimens.	Paraffin	176-184	tumor protein p53	Homo sapiens	40-43
1358427-4	1992	METHODS: Immunohistologic study of the c-erbB-2 gene product was done in formaldehyde-fixed paraffin-embedded tissue specimens obtained from 88 transitional cell carcinomas of the human urinary bladder.	Paraffin	92-100	erb-b2 receptor tyrosine kinase 2	Homo sapiens	39-47
1282509-1	1992	The distribution of the carbohydrate epitope CD15 was investigated on paraffin sections of the brains of man and mammals (monkey, dog, rabbit, rat, mouse, dolphin), reptile, bird and fish by means of immunohistochemistry.	Paraffin	70-78	fucosyltransferase 4	Homo sapiens	45-49
1295480-7	1992	Mutant p53-protein, as detected by immunohistochemistry in paraffin embedded tumor tissue, does not appear to influence metastasis-free survival in patients with breast cancer.	Paraffin	59-67	tumor protein p53	Homo sapiens	7-10
1362199-8	1992	Our results suggest that immunohistochemistry for CD15 is potentially useful in diagnostic neuropathology as a marker for granulocytes in paraffin sections, as a supplementary tool for the histopathological grading of gliomas, and as an aid for differentiation between anaplastic glioma cells and non-neoplastic glia.	Paraffin	138-146	fucosyltransferase 4	Homo sapiens	50-54
1282511-1	1992	The distribution of the carbohydrate epitope 3-fucosyl-N-acetyl-lactosamine (CD15) has been immunocytochemically evaluated in coronal paraffin sections through the magnocellular basal forebrain system--the nucleus basalis of Meynert, the nucleus of the diagonal band of Broca and the medial septal nucleus--of 202 human brains.	Paraffin	134-142	fucosyltransferase 4	Homo sapiens	77-81
1356909-0	1992	Detection of c-erbB-2 activation in paraffin-embedded tissue by immunohistochemistry.	Paraffin	36-44	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-21
1358045-3	1992	The present study evaluates c-erbB-2 protein over-production in sarcomas and in small round-cell tumors of childhood by applying an immunohistochemical technique to formalin-fixed, paraffin-embedded tissues.	Paraffin	181-189	erb-b2 receptor tyrosine kinase 2	Homo sapiens	28-36
1358781-3	1992	Immunoreactive p53 was observed in the nuclei of tumor cells in 4% paraformaldehyde-fixed, frozen sections (12 of 15) and paraffin-embedded sections (11 of 15), but not in routinely processed (10% formalin-fixed) specimens.	Paraffin	122-130	tumor protein p53	Homo sapiens	15-18
1356909-1	1992	Commercially available monoclonal antibodies were tested for their ability to detect increased levels of c-erbB-2 protein in formalin-fixed, paraffin-embedded breast carcinomas.	Paraffin	141-149	erb-b2 receptor tyrosine kinase 2	Homo sapiens	105-113
1356909-11	1992	Two additional antibodies (3B5 and N3/D10) detect c-erbB-2 protein overproduction in paraffin-embedded tissue, but are more difficult to interpret.	Paraffin	85-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	50-58
1475013-3	1992	As shown by double immunostaining of paraffin-embedded sections of the aggregates, this AII-LIR was localized only in gonadotrophs.	Paraffin	37-45	angiotensinogen	Rattus norvegicus	88-91
1444195-0	1992	Improved immunohistochemical detection of p53 protein in paraffin--embedded tissues reveals elevated levels in most head and neck and lung carcinomas: correlation with clinicopathological parameters.	Paraffin	57-65	tumor protein p53	Homo sapiens	42-45
1408139-6	1992	Five of the six cases showed involvement of the p53 gene as assessed by LOH at the AccII site within the gene, and by immunoreactivity to CM-1, an antibody which recognizes the mutated form of the p53 protein in paraffin-embedded material.	Paraffin	212-220	tumor protein p53	Homo sapiens	48-51
1408139-6	1992	Five of the six cases showed involvement of the p53 gene as assessed by LOH at the AccII site within the gene, and by immunoreactivity to CM-1, an antibody which recognizes the mutated form of the p53 protein in paraffin-embedded material.	Paraffin	212-220	tumor protein p53	Homo sapiens	197-200
1461572-2	1992	Immunohistochemistry on paraffin sections at postnatal days (P)7, 14, 21, 30 and 60 showed an overall similarity in laminar distribution of NPY neurons in all 3 visual areas of both normal- and dark-reared animals.	Paraffin	24-32	neuropeptide Y	Rattus norvegicus	140-143
1444195-3	1992	However, the antibody is effective in AMeX-fixed specimens, thereby permitting the improved morphologic localization of p53 phosphoprotein in paraffin embedded tissue.	Paraffin	142-150	tumor protein p53	Homo sapiens	120-123
1444195-1	1992	We have analyzed the expression of the p53 tumor suppressor gene in paraffin-embedded sections of normal and malignant head and neck and lung tumors by immunohistochemistry using the PAb 1801 monoclonal antibody (MAb).	Paraffin	68-76	tumor protein p53	Homo sapiens	39-42
1520594-1	1992	p53 expression was examined in 55 gastric and 107 colorectal carcinomas with an immunoperoxidase technique, using the polyclonal antibody CM1 on routinely fixed, paraffin embedded tissue.	Paraffin	162-170	tumor protein p53	Homo sapiens	0-3
1341005-0	1992	Detection of estrogen receptor in formalin-fixed and paraffin-embedded breast carcinoma: correlation with histological patterns.	Paraffin	53-61	estrogen receptor 1	Homo sapiens	13-30
1364264-1	1992	Monoclonal antibodies to the extracellular domain of the c-erbB-2 oncoprotein (p185) react with routinely processed, paraffin-embedded human tissues, and positive staining with these reagents has been shown to correlate with gene overexpression.	Paraffin	117-125	erb-b2 receptor tyrosine kinase 2	Homo sapiens	57-65
21584551-2	1992	With a monoclonal antibody for EGF-receptor and avidin-biotin-peroxidase complex (ABC), the expression of EGF-receptor was evaluated in paraffin-embedded sections.	Paraffin	136-144	epidermal growth factor receptor	Homo sapiens	106-118
1352359-8	1992	Overexpression of the p53 and c-erbB-2 proteins was studied immunohistochemically in archival paraffin-embedded tumor samples, using the CM-1 polyclonal and the TAb 250 monoclonal antibodies, respectively.	Paraffin	94-102	tumor protein p53	Homo sapiens	22-25
1381866-5	1992	Therefore, using monoclonal antibody D5, which allows ER-D5 detection of the estrogen receptor related antigen on paraffin sections, we investigated whether or not estrogen receptors are present in the prostatic cancer preparation and studied the survival rate of prostatic cancer as well as relationship with recurrence.	Paraffin	114-122	estrogen receptor 1	Homo sapiens	77-94
1607637-0	1992	p53 overexpression in formalin-fixed, paraffin-embedded tissue detected by immunohistochemistry.	Paraffin	38-46	tumor protein p53	Homo sapiens	0-3
1607637-3	1992	We examined p53 expression in paraffin-embedded tissues from 50 epithelial ovarian cancers and 25 primary breast cancers with a modified immunohistochemical (IHC) technique developed in this laboratory, using monoclonal antibody (MAb) PAb1801.	Paraffin	30-38	tumor protein p53	Homo sapiens	12-15
1607637-6	1992	Immunodetection of p53 in paraffin-embedded tissue blocks will be a useful alternative to the standard fresh-tissue assay and can accurately reflect the level of p53 expression in human tumors.	Paraffin	26-34	tumor protein p53	Homo sapiens	19-22
1505911-1	1992	The localization of the expression of several cytochrome P-450 genes in normal and diseased human liver was investigated by in situ hybridization of formalin-fixed, paraffin wax-embedded archival tissue samples with 35S-labeled antisense RNA probes.	Paraffin	165-177	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	46-62
1319835-9	1992	Also, carcinoma cells with p53 mutations existing within adenoma tissues are detectable by immunostaining, even in formalin-fixed, paraffin-embedded specimens.	Paraffin	131-139	tumor protein p53	Homo sapiens	27-30
1619684-9	1992	Protein expression of TP53 was seen by immunostaining of sections from paraffin-embedded material using a mouse monoclonal antibody.	Paraffin	71-79	tumor protein p53	Homo sapiens	22-26
1341005-1	1992	The authors studied the expression of estrogen receptor (ER) in tissues of breast carcinomas which were previously fixed in formalin and paraffin-embedded.	Paraffin	137-145	estrogen receptor 1	Homo sapiens	38-55
1341005-1	1992	The authors studied the expression of estrogen receptor (ER) in tissues of breast carcinomas which were previously fixed in formalin and paraffin-embedded.	Paraffin	137-145	estrogen receptor 1	Homo sapiens	57-59
1347094-3	1992	Mutations were not found in Ki-ras, but 9 p53 mutations, including 2 deletions, were found in 7 patients by direct DNA sequencing after polymerase chain reaction amplification of DNA from formalin-fixed, paraffin-embedded tissue.	Paraffin	204-212	tumor protein p53	Homo sapiens	42-45
1352125-5	1992	The present demonstration of positive c-erbB-2 immunostaining in papillary thyroid carcinomas is contradictory to previous findings on formalin-fixed, paraffin-embedded material, and emphasises the importance of tissue quality for c-erbB-2 protein detection.	Paraffin	151-159	erb-b2 receptor tyrosine kinase 2	Homo sapiens	38-46
1349163-1	1992	Amplification and overexpression of the HER2 (c-erbB-2) oncogene was assessed in paraffin-embedded specimens from 27 in situ carcinomas of the breast and from 122 stage II breast cancers.	Paraffin	81-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-44
1349163-1	1992	Amplification and overexpression of the HER2 (c-erbB-2) oncogene was assessed in paraffin-embedded specimens from 27 in situ carcinomas of the breast and from 122 stage II breast cancers.	Paraffin	81-89	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-54
1317462-3	1992	METHODS: IgG1 monoclonal antibody to human p53 protein (PAb 1801) and immunohistochemical methods were used to detect p53 protein accumulation in archival formalin-fixed, paraffin-embedded, randomly selected carcinomas.	Paraffin	171-179	tumor protein p53	Homo sapiens	118-121
1510215-1	1992	A total of 26 specimens of histologically determined, cutaneous Bowen"s disease from 23 patients were investigated for the incidence of mutant p53 protein expression by an indirect immunoperoxidase technique using the monoclonal antiserum CM1 on paraffin-embedded formalin-fixed tissue sections.	Paraffin	246-254	tumor protein p53	Homo sapiens	143-146
1358601-5	1992	Sequence analysis of the DNAs extracted from paraffin sections of pituitary, parathyroid, and pancreas tumors demonstrated the substitution of thymidine for cytidine in codon 201 of the Gs alpha gene that resulted in replacement of arginine (CGT) with cysteine (TGT) only in the pituitary adenoma, but not in the parathyroid and pancreas tumors.	Paraffin	45-53	GNAS complex locus	Homo sapiens	186-194
1357834-1	1992	We have studied the patterns of P-glycoprotein expression before and after 3 cycles of induction chemotherapy (5-fluorouracil, adriamycin and cyclophosphamide) using immunohistochemically stained paraffin-embedded specimen of 28 patients with locally advanced breast cancer.	Paraffin	196-204	ATP binding cassette subfamily B member 1	Homo sapiens	32-46
1374590-1	1992	Expression of bcl-2 protein was analyzed in 140 cases of follicular lymphoma by immunohistologic staining of paraffin-embedded tissue; 85% of cases were positive, the frequency being related to histologic grade (100% for the small-cleaved cell type, 86% for the mixed cell type, and 76% for the large cell group).	Paraffin	109-117	BCL2 apoptosis regulator	Homo sapiens	14-19
1625062-1	1992	Using a panel of polyclonal and monoclonal antibodies to CEA-related antigens in paraffin-processed cervical biopsies, CEA and NCA expression has been demonstrated on the cell membrane of normal mature cervical squames.	Paraffin	81-89	CEA cell adhesion molecule 3	Homo sapiens	57-60
1625062-1	1992	Using a panel of polyclonal and monoclonal antibodies to CEA-related antigens in paraffin-processed cervical biopsies, CEA and NCA expression has been demonstrated on the cell membrane of normal mature cervical squames.	Paraffin	81-89	CEA cell adhesion molecule 3	Homo sapiens	119-122
1625062-1	1992	Using a panel of polyclonal and monoclonal antibodies to CEA-related antigens in paraffin-processed cervical biopsies, CEA and NCA expression has been demonstrated on the cell membrane of normal mature cervical squames.	Paraffin	81-89	CEA cell adhesion molecule 4	Homo sapiens	127-130
1577221-5	1992	By immunohistochemical staining of paraffin-embedded tissues using a polyclonal antibody to c-erbB-2 gene products, the cell membrane was stained positively in three cases of gastric cancers which overexpressed c-erbB-2 mRNA.	Paraffin	35-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	92-100
1577221-5	1992	By immunohistochemical staining of paraffin-embedded tissues using a polyclonal antibody to c-erbB-2 gene products, the cell membrane was stained positively in three cases of gastric cancers which overexpressed c-erbB-2 mRNA.	Paraffin	35-43	erb-b2 receptor tyrosine kinase 2	Homo sapiens	211-219
1559760-4	1992	In this study, angiotensinogen (ANG) was localized using an affinity-purified antibody and paraffin sections of seven human eyes.	Paraffin	91-99	angiotensinogen	Homo sapiens	15-30
1559760-4	1992	In this study, angiotensinogen (ANG) was localized using an affinity-purified antibody and paraffin sections of seven human eyes.	Paraffin	91-99	angiotensinogen	Homo sapiens	32-35
1737400-4	1992	In the present study, mutations in the p53 gene were investigated by direct sequencing analysis after polymerase chain reaction amplification of exons 5 to 8, using paraffin-embedded primary tumors and cultured cells.	Paraffin	165-173	tumor protein p53	Homo sapiens	39-42
1371204-5	1992	A further MAb, IT-Ks20.8, recognized CK 20 in sections of formalin-fixed, paraffin-embedded tissue samples.	Paraffin	74-82	keratin 20	Homo sapiens	37-42
1546693-0	1992	Immunohistochemical study of p53 expression in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma.	Paraffin	64-72	tumor protein p53	Homo sapiens	29-32
1413493-1	1992	The expression of the p53 gene product was investigated immunocytochemically in a retrospective series of 164 formalin-fixed paraffin-embedded invasive breast carcinomas with pathologically proven negative lymph nodes.	Paraffin	125-133	tumor protein p53	Homo sapiens	22-25
1546693-1	1992	Expression of p53, a tumor-suppressor gene product, was studied immunohistochemically in microwave-fixed, paraffin-embedded sections of 84 colorectal carcinomas and 44 adenomas.	Paraffin	106-114	tumor protein p53	Homo sapiens	14-17
1546693-9	1992	The immunohistochemical detection of p53 in microwave-fixed, paraffin-embedded sections of colorectal carcinoma and adenoma can provide valuable information about the mechanism of carcinogenesis in colorectal epithelium.	Paraffin	61-69	tumor protein p53	Homo sapiens	37-40
1371175-3	1992	We evaluated 24 formalin fixed paraffin embedded tissue specimens of cervical carcinoma in situ for the presence of estrogen receptor by the immunoperoxidase technique.	Paraffin	31-39	estrogen receptor 1	Homo sapiens	116-133
1346366-3	1992	Immunohistochemical assessment of c-erbB-2 protein product expression was made using paraffin-embedded tumour tissue from 65 of these 72 patients.	Paraffin	85-93	erb-b2 receptor tyrosine kinase 2	Homo sapiens	34-42
1515241-1	1992	Expression of the oestrogen-regulated pS2 protein was investigated on paraffin-embedded sections of primary breast tumours from 200 node-negative patients.	Paraffin	70-78	taste 2 receptor member 64 pseudogene	Homo sapiens	38-41
1569122-5	1992	Most importantly, they also permit the detection of p53 in archival tumour material that has been conventionally fixed in formalin and embedded in paraffin wax.	Paraffin	147-159	tumor protein p53	Homo sapiens	52-55
1729539-9	1992	The antigen recognized by mAb Due ABC 3 was stable to fixation with formaldehyde and paraffin emmbedding, different proteases, alkaline treatment and heat exposure up to 70C.	Paraffin	85-93	ATP-binding cassette, sub-family A (ABC1), member 3	Mus musculus	34-39
1329310-2	1992	Recombinant tumour necrosis factor alpha (TNF) was biotinylated via amino-groups and the resultant probe was applied to formalin-fixed, paraffin-embedded tissue sections of 94 primary bronchial carcinomas and to normal peripheral lung parenchyma.	Paraffin	136-144	tumor necrosis factor	Homo sapiens	42-45
1350695-1	1992	The expression of the c-erbB-2 proto-oncogene product was investigated immunohistochemically in 474 formalin-fixed and paraffin-embedded human breast tissue samples.	Paraffin	119-127	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-30
16668669-1	1992	The distribution of napin and cruciferin, the two major storage proteins in rape seed, Brassica napus, has been visualized during seed development by antibody staining of paraffin-embedded and sectioned seeds.	Paraffin	171-179	cruciferin	Brassica napus	30-40
1375354-2	1992	Polyclonal antibody to apoB immunosustained senile plaque amyloid, vascular amyloid, subpial amyloid deposits and intracellular NFTs in formalin-fixed, paraffin-embedded brain sections from patients with Alzheimer disease.	Paraffin	152-160	apolipoprotein B	Homo sapiens	23-27
1371985-0	1992	Anti-CD34 immunoperoxidase staining in paraffin sections of acute leukemia: comparison with flow cytometric immunophenotyping.	Paraffin	39-47	CD34 molecule	Homo sapiens	5-9
1371985-9	1992	This is the first report of anti-CD34 staining of acute leukemia in paraffin-embedded sections.	Paraffin	68-76	CD34 molecule	Homo sapiens	33-37
1687240-1	1991	Detection of c-erbB-2 oncogene product expression by monoclonal antibody staining (avidin-biotin technique) in formalin-fixed, paraffin-embedded atypical hyperplasias (AH, n = 20), intraductal carcinomas (IDCA, n = 27) and invasive carcinomas (INVCA, n = 48) was compared to ploidy determinations obtained by flow cytometry (INVCA) or image analysis (AH, IDCA).	Paraffin	127-135	erb-b2 receptor tyrosine kinase 2	Homo sapiens	13-21
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Paraffin	93-101	interleukin 1 beta	Homo sapiens	56-65
1764370-4	1991	One of the antibodies, CM1, recognises p53 in formalin-fixed, paraffin-embedded archival material and using this reagent we found immunodetectable p53 in 28 of 124 (23%) pancreatic cancers.	Paraffin	62-70	tumor protein p53	Homo sapiens	39-42
1723130-1	1991	Monoclonal antibody QBEND10 is reactive with the CD34 antigen in aldehyde-fixed, decalcified, paraffin-embedded bone marrow biopsies.	Paraffin	94-102	CD34 molecule	Homo sapiens	49-53
1724084-6	1991	P-glycoprotein expression was identified in paraffin-embedded tissues by immunohistochemistry using monoclonal antibody C219 and was scored as the percentage of cells stained.	Paraffin	44-52	ATP binding cassette subfamily B member 1	Homo sapiens	0-14
1687809-2	1991	Formic acid pretreatment on formalin fixed, paraffin-embedded thin sections enhanced immunostaining of PrP in both congophilic and non-congophilic kuru plaques which were absent in sporadic CJD patients with short clinical courses.	Paraffin	44-52	prion protein	Homo sapiens	103-106
1682277-1	1991	c-erbB-2 protein over-expression was studied immunohistochemically in 319 paraffin-embedded breast carcinomas representing 89% of all breast-cancer cases operated in the Tampere University Hospital between 1977 and 1981.	Paraffin	74-82	erb-b2 receptor tyrosine kinase 2	Homo sapiens	0-8
1942310-12	1991	Immunohistochemical analysis with a p185HER-2/neu polyclonal antibody, on formalin fixed, paraffin embedded tissue, was specific for HER-2/neu overexpression but not as sensitive as Northern analysis.	Paraffin	90-98	erb-b2 receptor tyrosine kinase 2	Homo sapiens	46-49
1942310-12	1991	Immunohistochemical analysis with a p185HER-2/neu polyclonal antibody, on formalin fixed, paraffin embedded tissue, was specific for HER-2/neu overexpression but not as sensitive as Northern analysis.	Paraffin	90-98	erb-b2 receptor tyrosine kinase 2	Homo sapiens	40-49
1724087-0	1991	Myeloperoxidase: a specific marker for myeloid cells in paraffin sections.	Paraffin	56-64	myeloperoxidase	Homo sapiens	0-15
1724087-1	1991	Immunohistochemical detection of intracellular myeloperoxidase, a major constituent of primary granules of neutrophilic myeloid cells, was determined in paraffin sections of 161 specimens using a rabbit polyclonal antibody to human myeloperoxidase and an indirect immunoperoxidase technique.	Paraffin	153-161	myeloperoxidase	Homo sapiens	47-62
1724087-12	1991	Immunohistochemical detection of myeloperoxidase represents a sensitive and highly specific technique for identification of mature and immature myeloid cells in paraffin-embedded tissue.	Paraffin	161-169	myeloperoxidase	Homo sapiens	33-48
1756270-6	1991	This method allowed us to determine the ER B genotype of women with ER+ and ER- tumors, starting with minute amounts of DNA from frozen or paraffin embedded tissues.	Paraffin	139-147	estrogen receptor 1	Homo sapiens	40-42
24186521-1	1991	The plasma-membrane H(+)-ATPase (EC 3.6.1.35) of maize (Zea mays L.) coleoptiles and enclosed leaves has been localized at the optical-microscope level utilizing paraffin sections and a specific monoclonal antibody.	Paraffin	162-170	membrane H(+)-ATPase 1	Zea mays	4-31
1653518-7	1991	Chromogranin A mRNA, which codes for the major secretory granule protein, was present in 25/26 tumors including all tumors that were negative for pituitary hormone mRNAs, indicating adequate preservation of specific mRNA transcripts in the paraffin-embedded sections of tumor cells.	Paraffin	240-248	chromogranin A	Homo sapiens	0-14
1720817-0	1991	Immunohistochemical demonstration of keratin 7 in routinely fixed paraffin-embedded human tissues.	Paraffin	66-74	keratin 7	Homo sapiens	37-46
1720817-8	1991	Our study shows that the keratin 7 Mab OV-TL 12/30 is an excellent marker for tumour histopathology since it is reactive in paraffin-embedded formalin-fixed human tissues.	Paraffin	124-132	keratin 7	Homo sapiens	25-34
1681040-0	1991	Immunohistochemical detection of the epidermal growth factor receptor in paraffin-embedded human tissues.	Paraffin	73-81	epidermal growth factor receptor	Homo sapiens	37-69
1685075-1	1991	The expression of c-erb B-2 oncoprotein was studied immunohistochemically in paraffin embedded biopsy specimens of 91 female breast carcinomas.	Paraffin	77-85	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-27
32357643-0	1991	Expression of chromogranin a protein and messenger RNA and tyrosine hydroxylase protein in paraffin-embedded sections of neuroendocrine neoplasms.	Paraffin	91-99	chromogranin A	Homo sapiens	14-28
32357643-7	1991	These results indicate that tyrosine hydroxylase may be another useful marker for neuroblastic tumors and that chromogranin A mRNA can be detected in routinely processed formalin-fixed paraffin-embedded tissue sections.	Paraffin	185-193	chromogranin A	Homo sapiens	111-125
1951842-4	1991	The monoclonal anti-ERP H222 was used with a modified avidin-biotin-peroxidase complex (ABC) method and paraffin sections.	Paraffin	104-112	ETS transcription factor ELK3	Homo sapiens	20-23
1923535-2	1991	Immunohistochemical staining with new polyclonal (CM-1) and monoclonal antibodies (BP 53-12 and BP53-24) to p53 on methacarn-fixed paraffin sections showed positive staining in 161 (76%).	Paraffin	131-139	BP53	Homo sapiens	83-88
1923535-2	1991	Immunohistochemical staining with new polyclonal (CM-1) and monoclonal antibodies (BP 53-12 and BP53-24) to p53 on methacarn-fixed paraffin sections showed positive staining in 161 (76%).	Paraffin	131-139	tumor protein p53	Homo sapiens	108-111
1681040-1	1991	Expression of the epidermal growth factor (EGF) receptor was evaluated by immunohistochemical staining of formalin-fixed, paraffin-embedded tumour tissues employing two antibodies raised to short synthetic peptides from the cytoplasmic domain of the molecule.	Paraffin	122-130	epidermal growth factor receptor	Homo sapiens	18-56
1715411-0	1991	[Demonstration of PIVKA-II and AFP production by gastric cancer by indirect immunoenzymatic staining of paraffin sections].	Paraffin	104-112	alpha fetoprotein	Homo sapiens	18-34
1722381-2	1991	Using an immunohistochemical technique and a panel of monoclonal antibodies we have localized IFN-alpha, -beta and -gamma directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy and in the hydatidiform mole.	Paraffin	149-157	interferon alpha 1	Homo sapiens	94-121
1721722-0	1991	Detection of P-glycoprotein with JSB-1 monoclonal antibody in B-5 fixed and paraffin-embedded cell lines and tissues.	Paraffin	76-84	ATP binding cassette subfamily B member 1	Homo sapiens	13-27
1721722-1	1991	We analyzed the expression of P-glycoprotein (Pgp) by immunohistochemistry using JSB-1 monoclonal antibody (MAb) on paraffin-embedded sections of the multi-drug resistant (MDR) (CHrC5 and CEM-VLB), and sensitive (AuxB1 and CEM) cell lines, and also in normal kidney, colon, adrenal and in kidney and colon carcinomas.	Paraffin	116-124	ATP binding cassette subfamily B member 1	Homo sapiens	30-44
1721722-1	1991	We analyzed the expression of P-glycoprotein (Pgp) by immunohistochemistry using JSB-1 monoclonal antibody (MAb) on paraffin-embedded sections of the multi-drug resistant (MDR) (CHrC5 and CEM-VLB), and sensitive (AuxB1 and CEM) cell lines, and also in normal kidney, colon, adrenal and in kidney and colon carcinomas.	Paraffin	116-124	ATP binding cassette subfamily B member 1	Homo sapiens	46-49
1679345-0	1991	Quantitation of HER-2/neu oncoprotein overexpression in invasive breast cancer by image analysis: a study comparing fresh and paraffin-embedded material.	Paraffin	126-134	erb-b2 receptor tyrosine kinase 2	Homo sapiens	16-25
1679345-5	1991	There was in general a good concordance (r = 0.83) in HER-2/neu expression values between fresh and paraffin-embedded material.	Paraffin	100-108	erb-b2 receptor tyrosine kinase 2	Homo sapiens	54-63
1679345-9	1991	It was concluded that both fresh-frozen and paraffin-embedded, formalin-fixed material is suitable for assessment of HER-2/neu protein overexpression by image analysis and provides comparable HER-2/neu expression values in most cases.	Paraffin	44-52	erb-b2 receptor tyrosine kinase 2	Homo sapiens	117-126
1681535-0	1991	Immunohistochemical assay of neu/c-erbB-2 oncogene product in paraffin-embedded tissues in early breast cancer: retrospective follow-up study of 245 stage I and II cases.	Paraffin	62-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-32
1681535-0	1991	Immunohistochemical assay of neu/c-erbB-2 oncogene product in paraffin-embedded tissues in early breast cancer: retrospective follow-up study of 245 stage I and II cases.	Paraffin	62-70	erb-b2 receptor tyrosine kinase 2	Homo sapiens	33-41
1681535-1	1991	The expression of neu oncoprotein was assayed by immunohistochemistry (IHC) on 245 paraffin-embedded, Stage I and II breast cancers from patients treated at the City of Hope between the years 1980 and 1987.	Paraffin	83-91	erb-b2 receptor tyrosine kinase 2	Homo sapiens	18-21
1852132-8	1991	Although detection of ER protein in paraffin sections correlates highly with the biochemical assay in this report and in other reported studies, the clinical significance of increased sensitivity by ISH is unknown and must await clinical correlative follow-up studies.	Paraffin	36-44	estrogen receptor 1	Homo sapiens	22-24
1949914-0	1991	Demonstration of estrogen receptor by immunohistochemical staining in paraffin sections of breast carcinoma.	Paraffin	70-78	estrogen receptor 1	Homo sapiens	17-34
1852132-0	1991	Detection of estrogen receptor in paraffin-embedded sections of breast carcinoma by immunohistochemistry and in situ hybridization.	Paraffin	34-42	estrogen receptor 1	Homo sapiens	13-30
1672256-1	1991	The expression of the c-erbB-2 oncogene has been evaluated using an immunohistochemical technique with the 21N polyclonal antibody in paraffin embedded tissue from 465 patients treated between the years 1975-1981 for Stage I and II breast cancer.	Paraffin	134-142	erb-b2 receptor tyrosine kinase 2	Homo sapiens	22-30
1852132-2	1991	Recent reports from various laboratories have shown the utility of immunohistochemical detection of ER protein in paraffin-embedded tissue sections.	Paraffin	114-122	estrogen receptor 1	Homo sapiens	100-102
2025606-8	1991	We conclude that the expression EGF-R can be detected reliably by the F4 antibody in both the fresh frozen and formalin fixed, paraffin embedded material and could be useful in assessing the clinical importance of EGF-R in archival tumour material.	Paraffin	127-135	epidermal growth factor receptor	Homo sapiens	32-37
1852132-6	1991	These results indicate that ER protein can be readily detected in enzyme-treated paraffin tissue sections and that the IHC detection of ER protein correlates highly with the DCC assay.	Paraffin	81-89	estrogen receptor 1	Homo sapiens	28-30
1850611-1	1991	Expression of the oestrogen-regulated pNR-2/pS2 protein has been studied in paraffin sections of a series of 172 primary breast cancers using an immunohistochemical technique.	Paraffin	76-84	trefoil factor 1	Homo sapiens	38-43
1850611-1	1991	Expression of the oestrogen-regulated pNR-2/pS2 protein has been studied in paraffin sections of a series of 172 primary breast cancers using an immunohistochemical technique.	Paraffin	76-84	trefoil factor 1	Homo sapiens	44-47
1705091-1	1991	The authors immunohistochemically assessed the presence of estrogen receptor (ER) in formalin-fixed, paraffin-embedded tissue sections of 68 breast carcinomas by an automated method using Pronase (CalBiochem, La Jolla, CA) predigestion and alkaline phosphatase detection (Method 1).	Paraffin	101-109	estrogen receptor 1	Homo sapiens	59-76
1705091-1	1991	The authors immunohistochemically assessed the presence of estrogen receptor (ER) in formalin-fixed, paraffin-embedded tissue sections of 68 breast carcinomas by an automated method using Pronase (CalBiochem, La Jolla, CA) predigestion and alkaline phosphatase detection (Method 1).	Paraffin	101-109	estrogen receptor 1	Homo sapiens	78-80
1705091-5	1991	These findings indicate that ER immunohistochemical studies on formalin-fixed paraffin-embedded tissues (as assayed by Method 1) provide useful clinical information when the results are positive.	Paraffin	78-86	estrogen receptor 1	Homo sapiens	29-31
1707960-2	1991	Two peptides were immunogenic in rabbits and antisera against one peptide reacted with the pNR-2 protein in sections of formalin-fixed, paraffin-embedded breast tumour.	Paraffin	136-144	trefoil factor 1	Homo sapiens	91-96
1707090-1	1991	Sequential immunocytochemical double labeling of glial fibrillary acidic protein (GFAP) and transferrin (Tf) was used for the simultaneous identification of astrocytes and oligodendrocytes in paraffin-embedded sections of the rat brain.	Paraffin	192-200	transferrin	Rattus norvegicus	105-107
1670998-1	1991	Using a polyclonal antibody that is monospecific for the erbB-2 oncogene product, an immunohistochemical study of the expression of erbB-2 protein was performed in formalin-fixed paraffin-embedded tissue sections from 260 primary gastric cancers.	Paraffin	179-187	erb-b2 receptor tyrosine kinase 2	Homo sapiens	132-138
1924172-5	1991	The original paraffin-embedded specimen from which this mutant cell line was established was obtained, and sequence analysis detected the identical mutation in the p53 gene as that seen in the derived cell line.	Paraffin	13-21	tumor protein p53	Homo sapiens	164-167
1708502-0	1991	Image analysis for quantitation of estrogen receptor in formalin-fixed paraffin-embedded sections of breast carcinoma.	Paraffin	71-79	estrogen receptor 1	Homo sapiens	35-52
1958387-0	1991	Estrogen receptor in primary breast cancer estimated in paraffin-embedded tissue.	Paraffin	56-64	estrogen receptor 1	Homo sapiens	0-17
1958387-2	1991	Estrogen receptor (ER) was estimated immunohistochemically in formalin-fixed and paraffin-embedded tissue from the primary breast cancer in 349 postmenopausal patients with a high risk of recurrence and compared with the results of dextran-coated charcoal assay.	Paraffin	81-89	estrogen receptor 1	Homo sapiens	0-17
1958387-2	1991	Estrogen receptor (ER) was estimated immunohistochemically in formalin-fixed and paraffin-embedded tissue from the primary breast cancer in 349 postmenopausal patients with a high risk of recurrence and compared with the results of dextran-coated charcoal assay.	Paraffin	81-89	estrogen receptor 1	Homo sapiens	19-21
1958387-8	1991	The same was true for receptor-defined subgroups regardless if the ER receptor was estimated in paraffin-embedded tissue or by the dextran-coated charcoal method.	Paraffin	96-104	estrogen receptor 1	Homo sapiens	67-69
1935457-1	1991	Nuclear debris may significantly interfere with the analysis of S-phase fraction (SPF) from paraffin-embedded tumors.	Paraffin	92-100	SEC14 like lipid binding 2	Homo sapiens	82-85
1935458-0	1991	Flow cytometric measurement of p53 protein expression and DNA content in paraffin-embedded tissue from bronchial carcinomas.	Paraffin	73-81	tumor protein p53	Homo sapiens	31-34
1935458-3	1991	After immunostaining, the nuclei prepared from paraffin-embedded tissue were stained with propidium iodide for simultaneous measurement of DNA content; 17 of 24 lung cancers were p53 positive.	Paraffin	47-55	tumor protein p53	Homo sapiens	179-182
1935458-9	1991	In conclusion, using the monoclonal antibody PAb 1801, p53 is detectable in cell nuclei prepared from paraffin-embedded bronchial carcinoma biopsies.	Paraffin	102-110	tumor protein p53	Homo sapiens	55-58
1856109-1	1991	The distribution of the mRNAs for chromogranin A and B was analyzed by in situ hybridization with 35S-labeled oligonucleotide probes in formalin-fixed paraffin-embedded carcinoid tumor tissues.	Paraffin	151-159	chromogranin A	Homo sapiens	34-54
1953367-2	1991	Main mechanisms of the ultrasound effects on tissues as well as a method of the UTP-1 apparatus use for the acceleration of the paraffin embedding are presented.	Paraffin	128-136	PWP2 small subunit processome component	Homo sapiens	80-85
1680118-3	1991	In this study immunohistochemical staining for p53-protein was performed on frozen- and paraffin-embedded samples from patients with Hodgkin"s (HD) and non-Hodgkin"s lymphomas (NHL).	Paraffin	88-96	tumor protein p53	Homo sapiens	47-50
1667050-2	1991	We conclude, that the lysozyme content of sarcoidotic granulomas, estimated immunohistochemically, may be a useful morphological parameter of the activity of the disease, applicable on formol fixed and paraffin embedded bioptical material.	Paraffin	202-210	lysozyme	Homo sapiens	22-30
1651583-1	1991	Pro-opiomelanocortin (POMC) mRNA was detected on paraffin sections by in situ hybridization (ISH) in corticotrophs of 12 nontumorous pituitaries, 11 functioning corticotroph, and 11 silent pituitary adenomas.	Paraffin	49-57	proopiomelanocortin	Homo sapiens	0-20
1651583-1	1991	Pro-opiomelanocortin (POMC) mRNA was detected on paraffin sections by in situ hybridization (ISH) in corticotrophs of 12 nontumorous pituitaries, 11 functioning corticotroph, and 11 silent pituitary adenomas.	Paraffin	49-57	proopiomelanocortin	Homo sapiens	22-26
1724830-8	1991	The virus-antigen p24 could neither be detected immunohistochemically in the paraffin sections nor in the frozen material of the brain or by in-situ-hybridization.	Paraffin	77-85	transmembrane p24 trafficking protein 2	Homo sapiens	18-21
2254647-3	1990	The immunolocalization of TGF-beta 2 was investigated in formalin-fixed, paraffin-embedded cultured cells and murine tissue.	Paraffin	73-81	transforming growth factor, beta 2	Mus musculus	26-36
2133250-9	1990	We localized pro-uPA/uPA immunohistochemically in paraffin-embedded formalin-fixed breast cancer tissue sections.	Paraffin	50-58	plasminogen activator, urokinase	Homo sapiens	17-20
2133250-9	1990	We localized pro-uPA/uPA immunohistochemically in paraffin-embedded formalin-fixed breast cancer tissue sections.	Paraffin	50-58	plasminogen activator, urokinase	Homo sapiens	21-24
1701822-10	1990	The expression of endothelins in tissue macrophages was demonstrated in paraffin sections of human lung using immunohistochemistry.	Paraffin	72-80	endothelin 1	Homo sapiens	18-29
1973458-0	1990	NCL-CB11, a new monoclonal antibody recognizing the internal domain of the c-erbB-2 oncogene protein effective for use on formalin-fixed, paraffin-embedded tissue.	Paraffin	138-146	erb-b2 receptor tyrosine kinase 2	Homo sapiens	75-83
2121042-4	1990	The V kappa or V lambda subgroup of the cIg or sIg also could be identified after deparaffinization and enzyme treatment of formalin-fixed, paraffin-embedded specimens.	Paraffin	84-92	fibronectin 1	Homo sapiens	40-43
1695726-9	1990	The high expression results in easy and specific detection of the antigen in immunocytochemical analysis of paraffin embedded tissue sections making HBA-71 a useful tool in tumor diagnosis.	Paraffin	108-116	CD99 molecule (Xg blood group)	Homo sapiens	149-155
2372497-1	1990	Relationship of EGF-R with histology and survival using fixed paraffin embedded tissue and the F4, monoclonal antibody.	Paraffin	62-70	epidermal growth factor receptor	Homo sapiens	16-21
2372497-2	1990	The expression of epidermal growth factor receptor (EGF-R) in 34 formalin fixed paraffin embedded specimens of malignant mesothelioma was examined using the F4 antibody.	Paraffin	80-88	epidermal growth factor receptor	Homo sapiens	18-50
2372497-2	1990	The expression of epidermal growth factor receptor (EGF-R) in 34 formalin fixed paraffin embedded specimens of malignant mesothelioma was examined using the F4 antibody.	Paraffin	80-88	epidermal growth factor receptor	Homo sapiens	52-57
1976118-6	1990	Paraffin sections from all 19 tumors with c-erbB-2 amplification, and those from only one of 104 tumors without the amplification were positively stained with polyclonal anti-c-erbB-2 protein antibody.	Paraffin	0-8	erb-b2 receptor tyrosine kinase 2	Homo sapiens	175-183
2277146-4	1990	Although a few melanosomes in the tumor cells seen in electron microscopic examination provided crucial proof for the diagnosis of Spitz nevus, the positive reactivity to S-100 protein in ordinary formalin-fixed, paraffin-embedded tissues proved to be very useful in the differentiation of Spitz nevus from tumors of histiocytic origin, especially those of the mononuclear phagocytic system.	Paraffin	213-221	S100 calcium binding protein A1	Homo sapiens	171-176
2192300-2	1990	For this purpose, we developed a sensitive immunoperoxidase technique to visualize MEnk-positive patches in routinely prepared formalin-fixed paraffin-embedded striatal tissues.	Paraffin	142-150	proopiomelanocortin	Homo sapiens	83-87
2373290-2	1990	Using antibodies to laminin in paraffin sections and cultured embryos, we have studied the distribution of laminin and its involvement in the first morphogenetic events, beginning with the first extensive cellular migrations and interactions that result in the induction of the primitive streak (PS) and of the neural plate in the early chick embryo.	Paraffin	31-39	laminin, beta 2 (laminin S)	Gallus gallus	20-27
2112420-3	1990	We examined the distribution of the MS1-EL4 cell derivatives by staining whole embryos with X-gal and by making serial paraffin sections.	Paraffin	119-127	muscle size 1	Mus musculus	36-39
1973161-1	1990	Using a polyclonal antibody monospecific to the c-erbB-2 oncogene product, an immunohistochemical study on the expression of c-erbB-2 protein was performed in formalin-fixed, paraffin-embedded tissue sections from 176 primary breast carcinomas in which amplification of the c-erbB-2 gene had been detected in 28 cases.	Paraffin	175-183	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-133
1973161-1	1990	Using a polyclonal antibody monospecific to the c-erbB-2 oncogene product, an immunohistochemical study on the expression of c-erbB-2 protein was performed in formalin-fixed, paraffin-embedded tissue sections from 176 primary breast carcinomas in which amplification of the c-erbB-2 gene had been detected in 28 cases.	Paraffin	175-183	erb-b2 receptor tyrosine kinase 2	Homo sapiens	125-133
2110593-1	1990	The aspartic proteinase zymogen, progastricsin, which occurs in normal gastroduodenal mucosa and prostate, has been localized by the immunogold-silver method in formalin-fixed, paraffin-embedded sections of metastatic adenocarcinoma in lymph nodes and liver, the primary site being known in each case.	Paraffin	177-185	progastricsin	Homo sapiens	33-46
2187320-7	1990	The antigenicity of CEA and NCA in normal tissues was significantly lost after paraffin embedding as compared to frozen sections.	Paraffin	79-87	CEA cell adhesion molecule 3	Homo sapiens	20-23
2303291-2	1990	We have studied immunohistochemically the incidence of alpha 1-AT on histologic sections from paraffin-embedded tissues of surgically resected colorectal carcinomas and their metastatic foci, polypectomized adenomas, and normal mucosae.	Paraffin	94-102	serpin family A member 1	Homo sapiens	55-65
2187320-7	1990	The antigenicity of CEA and NCA in normal tissues was significantly lost after paraffin embedding as compared to frozen sections.	Paraffin	79-87	CEA cell adhesion molecule 4	Homo sapiens	28-31
2187320-8	1990	NCA was consistently demonstrated in eccrine sweat glands embedded in paraffin.	Paraffin	70-78	CEA cell adhesion molecule 4	Homo sapiens	0-3
2154140-7	1990	The methodology for the ER-ICA assay was more technically demanding in paraffin sections than that of the estradiol antibody and considerably more expensive.	Paraffin	71-79	estrogen receptor 1	Homo sapiens	24-26
2187320-9	1990	In various tumor tissues, CEA and NCA were colocalized and expression increased sufficiently to be detected in paraffin sections.	Paraffin	111-119	CEA cell adhesion molecule 3	Homo sapiens	26-29
2187320-9	1990	In various tumor tissues, CEA and NCA were colocalized and expression increased sufficiently to be detected in paraffin sections.	Paraffin	111-119	CEA cell adhesion molecule 4	Homo sapiens	34-37
1969111-7	1990	Labelling for c-erbB-2 protein was generally weaker in paraffin sections than in frozen sections and in six of 11 positive cases, specific staining could be detected only in frozen sections.	Paraffin	55-63	erb-b2 receptor tyrosine kinase 2	Homo sapiens	14-22
33816221-4	2021	Case Study: We report about SCCT that occurred 45 months after the initial diagnosis of ADC in an East Asian never-smoker woman with advanced-stage EGFR Del-19-mutant lung ADC treated with combined chemoradiotherapy before the era of insurance coverage for EGFR-TKIs in this country and subsequently gefitinib; deletion at codon 746-750 in exon 19 of the EGFR gene was ascertained in the original formalin-fixed paraffin-embedded lung biopsy tissue.	Paraffin	412-420	epidermal growth factor receptor	Homo sapiens	148-152
1698166-4	1990	The monoclonal antibodies to c-erbB-2 and EGF-R immunostained subpopulations of tumour cells on sections of formalin-fixed, paraffin wax embedded human infiltrating and invasive ductal carcinomas of breast.	Paraffin	124-136	erb-b2 receptor tyrosine kinase 2	Homo sapiens	29-37
2403579-1	1990	We investigated the immunoperoxidase demonstration of vasopressin (VSP) bound to paraffin-embedded sections of rat kidney and the effects of various fixatives.	Paraffin	81-89	arginine vasopressin	Rattus norvegicus	54-65
2403579-1	1990	We investigated the immunoperoxidase demonstration of vasopressin (VSP) bound to paraffin-embedded sections of rat kidney and the effects of various fixatives.	Paraffin	81-89	arginine vasopressin	Rattus norvegicus	67-70
2190198-1	1990	Langerhans cells and their pathologic counterparts can be identified in paraffin sections using immunohistochemical staining for S-100 protein.	Paraffin	72-80	S100 calcium binding protein A1	Homo sapiens	129-134
33811629-5	2021	METHODS: In the present study, the expression of TYRP1 and HIF-1alpha was investigated on 61 formalin-fixed paraffin-embedded choroidal melanoma samples by immunohistochemistry.	Paraffin	108-116	tyrosinase related protein 1	Homo sapiens	49-54
33811629-5	2021	METHODS: In the present study, the expression of TYRP1 and HIF-1alpha was investigated on 61 formalin-fixed paraffin-embedded choroidal melanoma samples by immunohistochemistry.	Paraffin	108-116	hypoxia inducible factor 1 subunit alpha	Homo sapiens	59-69
33768318-3	2021	In this study, we aim to validate the diagnostic performance of multiplex BCL2/BCL6 FISH approach in formalin-fixed paraffin-embedded FLs and DBCLs and cytological samples of DLBCL comparing to the classic set of single break-apart probes.	Paraffin	116-124	BCL2 apoptosis regulator	Homo sapiens	74-78
1698166-4	1990	The monoclonal antibodies to c-erbB-2 and EGF-R immunostained subpopulations of tumour cells on sections of formalin-fixed, paraffin wax embedded human infiltrating and invasive ductal carcinomas of breast.	Paraffin	124-136	epidermal growth factor receptor	Homo sapiens	42-47
2088481-6	1990	Conditions are described for use of HCA2 and HC10 in immunohistochemical staining of formalin-fixed, paraffin-embedded sections.	Paraffin	101-109	CYCS pseudogene 25	Homo sapiens	45-49
34894899-5	2022	Positive immunolabeling for CPA3 was observed in nonneoplastic mast cells in 20/20 formalin-fixed paraffin-embedded normal tissues (skin, liver, spleen, intestine), and in 63/63 MCTs irrespective of their histological grade.	Paraffin	98-106	carboxypeptidase A3	Canis lupus familiaris	28-32
34775733-7	2022	Immunohistochemistry for PLK4 in paraffin-embedded tissue was performed from the biopsy and surgical specimens.	Paraffin	33-41	polo like kinase 4	Homo sapiens	25-29
34810101-7	2022	Consequently, the findings of this study highlighted the rapid diagnosis of gastric and colon cancer cases from paraffin-embedded tissues via ATR-MIR spectroscopy complemented with chemometrics.	Paraffin	112-120	ATR serine/threonine kinase	Homo sapiens	142-145
34635261-2	2022	The solid microparticles of Pb(II) (Pb(CH3COO)2(s)) immobilized into the carbon paste sensor containing carbon black and paraffin were firstly reduced at initial potentials and further reoxidized at around -0.60 V during anodic scan.	Paraffin	121-129	submaxillary gland androgen regulated protein 3B	Homo sapiens	28-34
34391866-5	2021	Using the high-throughput RNA-sequencing data from TCGA and paraffin-embedded specimens from two cohorts, our study uncovered that the expression of HADH was significantly associated with the overall survival and the infiltrating level of tumor-infiltrating immune cells in KIRC, particularly the Tregs, which suggested that HADH could be a novel potential prognostic biomarker and therapeutic targets in KIRC.	Paraffin	60-68	hydroxyacyl-CoA dehydrogenase	Homo sapiens	149-153
34391866-5	2021	Using the high-throughput RNA-sequencing data from TCGA and paraffin-embedded specimens from two cohorts, our study uncovered that the expression of HADH was significantly associated with the overall survival and the infiltrating level of tumor-infiltrating immune cells in KIRC, particularly the Tregs, which suggested that HADH could be a novel potential prognostic biomarker and therapeutic targets in KIRC.	Paraffin	60-68	hydroxyacyl-CoA dehydrogenase	Homo sapiens	325-329
34344387-3	2021	This study aimed to validate the Idylla  platform for the detection of EGFR/KRAS mutations in cytological NSCLC samples prepared as cytoblocks using AGAR and paraffin embedding.	Paraffin	158-166	epidermal growth factor receptor	Homo sapiens	71-75
34531104-3	2022	Immunohistochemical methods were used to detect BASP1 expression in 100 paraffin-embedded specimens of TSCC tissue.	Paraffin	72-80	brain abundant membrane attached signal protein 1	Homo sapiens	48-53
34400544-3	2021	The Idylla EGFR mutation test (IEMT) has been specifically designed to process formalin-fixed paraffin-embedded sections without requiring preliminary DNA extraction.This study aims to evaluate the diagnostic accuracy of IEMT when used to analyse archival histopathology material.	Paraffin	94-102	epidermal growth factor receptor	Homo sapiens	11-15
34362389-7	2021	Immunohistochemistry (IHC) staining was performed to evaluate the expression of NAT10 in formalin fixed paraffin-embedded (FFPE) samples of HNSCC.	Paraffin	104-112	N-acetyltransferase 10	Homo sapiens	80-85
34829293-3	2021	PXR protein expression was assessed immunohistochemically on formalin fixed paraffin-embedded breast invasive carcinoma tissue sections, obtained from 148 patients, and was correlated with clinicopathological parameters, molecular phenotypes, tumor cells" proliferative capacity, and overall disease-free patients" survival.	Paraffin	76-84	nuclear receptor subfamily 1 group I member 2	Homo sapiens	0-3
34341374-0	2021	Author Correction: Machine learning algorithm improved automated droplet classification of ddPCR for detection of BRAF V600E in paraffin-embedded samples.	Paraffin	128-136	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	114-118
34289525-1	2021	We previously reported the usefulness of droplet digital polymerase chain reaction (ddPCR) for the assessment of Human epithelial growth factor receptor 2 (HER2) gene amplification in breast cancer using formalin-fixed and paraffin-embedded sections.	Paraffin	223-231	erb-b2 receptor tyrosine kinase 2	Homo sapiens	156-160
34116682-5	2021	The type of sample (peripheral blood and formalin-fixed paraffin-embedded tissue) used for testing was significantly associated with the BRAF V600E mutation status (p-value = 0.000 and 0.000).	Paraffin	56-64	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	137-141
34298614-2	2021	To clarify the potential of AKR1B1 and AKR1B10 as tissue biomarkers of endometrial cancer, we evaluated the immunohistochemical levels of AKR1B1 and AKR1B10 in tissue paraffin sections from 101 well-characterized patients with endometrioid endometrial cancer and 12 patients with serous endometrial cancer and compared them with the clinicopathological data.	Paraffin	167-175	aldo-keto reductase family 1 member B	Homo sapiens	138-144
34266469-5	2021	We study HER2 amplification in ductal carcinoma in situ (DCIS) as an event that can be both quantified and spatially located via fluorescence in situ hybridization (FISH) and immunohistochemistry on fixed paraffin-embedded tissue.	Paraffin	205-213	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
34136904-3	2021	We evaluated the analytical performance of a targeted mass spectrometry-based assay for quantifying HER2 protein in formalin-fixed paraffin-embedded (FFPE) and frozen BC biopsies.	Paraffin	131-139	erb-b2 receptor tyrosine kinase 2	Homo sapiens	100-104
34135377-0	2021	Machine learning algorithm improved automated droplet classification of ddPCR for detection of BRAF V600E in paraffin-embedded samples.	Paraffin	109-117	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	95-99
34178624-3	2021	Materials and Methods: We verify a co-expression of BRAF V600E mutation and PD-L1 high expression more than 50% on formalin-fixed paraffin-embedded tumor sample of a newly diagnosed lung adenocarcinoma patient by immunohistochemistry and BRAF V600E/EGFR/ALK/ROS1 Mutations Detection Kit.	Paraffin	130-138	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	52-56
34551701-3	2021	OBJECTIVES: The present study aimed to investigate Myosin Light Chain 9(MYL9) expression in Epithelial Ovarian Cancer (EOC) tissues (including paraffin-embedded and fresh tissue samples) and its relationship with clinicopathological characteristics, as well as its potential prognostic value in patients with EOC.	Paraffin	143-151	myosin light chain 9	Homo sapiens	51-71
34127544-6	2021	In a targeted gene expression profiling of pre-treatment tumor biopsies in 11 patients with available formalin-fixed, paraffin-embedded tissue, we observed that KIT, ATG12, TNFRSF10C, PBK, ITGA2, GATA3, CLU, NCAM1, SYT17 and LTK were differentially expressed in patients with responder versus non-responder tumors.	Paraffin	118-126	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	161-164
34236631-3	2021	This chapter describes how to identify and localize NF-kappaB proteins in human tissue using immunohistochemical staining on formalin-fixed paraffin-embedded and frozen tissue.	Paraffin	140-148	nuclear factor kappa B subunit 1	Homo sapiens	52-61
34551701-3	2021	OBJECTIVES: The present study aimed to investigate Myosin Light Chain 9(MYL9) expression in Epithelial Ovarian Cancer (EOC) tissues (including paraffin-embedded and fresh tissue samples) and its relationship with clinicopathological characteristics, as well as its potential prognostic value in patients with EOC.	Paraffin	143-151	myosin light chain 9	Homo sapiens	72-76
35574028-4	2022	We observed and quantified the expression of apelin, SDHB, CHGB, ERBB-2, CNTN4, and SUCLG2 in paraffin-embedded samples using immunohistochemical staining.	Paraffin	94-102	apelin	Homo sapiens	45-51
35501674-2	2022	Materials and Methods: PSMA-antibody was applied to the paraffin blocks of 51 patients who were diagnosed with squamous cell carcinoma of the larynx and underwent laryngectomy and one who underwent lymph node dissection.	Paraffin	56-64	folate hydrolase 1	Homo sapiens	23-27
35574415-3	2022	Methods: HER2 protein expression was tested by immunohistochemistry (IHC) in formalin-fixed, paraffin-embedded (FFPE) samples from 4,836 CRC patients in our institution.	Paraffin	93-101	erb-b2 receptor tyrosine kinase 2	Homo sapiens	9-13
35468339-0	2022	Distinct expression signatures of miR-130a, miR-301a, miR-454 in formalin fixed paraffin embedded tissue samples of prostate cancer patients.	Paraffin	80-88	microRNA 454	Homo sapiens	54-61
35468339-5	2022	Accordingly, in the present study, we aimed to reveal the clinical significance of miR-130a, miR-301a, miR-454 expression levels in formalin fixed paraffin embedded (FFPE) tissue samples of prostate cancer patients.	Paraffin	147-155	microRNA 454	Homo sapiens	103-110
35574028-4	2022	We observed and quantified the expression of apelin, SDHB, CHGB, ERBB-2, CNTN4, and SUCLG2 in paraffin-embedded samples using immunohistochemical staining.	Paraffin	94-102	erb-b2 receptor tyrosine kinase 2	Homo sapiens	65-71
35459777-3	2022	Therefore, we developed an automated high-throughput mIF workflow for quantitative single-cell level assessment of formalin fixed paraffin embedded tissue (FFPE), leveraging tyramide signal amplification on a Ventana Ultra platform coupled with automated multispectral imaging on a Vectra 3 platform.	Paraffin	130-138	macrophage migration inhibitory factor (glycosylation-inhibiting factor)	Mus musculus	53-56
35565309-4	2022	Droplet digital PCR (ddPCR) was used to implement the assessment of HER2 status in formalin-fixed paraffin-embedded (FFPE) tumor DNA from a retrospective cohort (86 patients) and in cell-free DNA (cfDNA) samples from a prospective cohort (28 patients).	Paraffin	98-106	erb-b2 receptor tyrosine kinase 2	Homo sapiens	68-72
35412687-12	2022	The KIT D816V mutation in formalin fixed paraffin embedded (FFPE) skin was evaluable in 87.5% of MCPM patients and had both 100% sensitivity and specificity.	Paraffin	41-49	KIT proto-oncogene, receptor tyrosine kinase	Homo sapiens	4-7
35265254-3	2022	We carried out a preliminary evaluation of PLAG1 translocation by fluorescence in-situ hybridization (FISH), immunohistochemistry (IHC) and HMGA2 IHC on twenty-five archived formalin-fixed paraffin-embedded tissues of PAs and its clinicopathologic features.	Paraffin	189-197	PLAG1 zinc finger	Homo sapiens	43-48
35014680-4	2022	TGM2 expression was shown to be elevated in formalin-fixed paraffin-embedded skin biopsies from patients with T-cell lymphoma relative to skin tissue from healthy cases.	Paraffin	59-67	transglutaminase 2	Homo sapiens	0-4
35202002-2	2022	METHODS: Immunohistochemistry staining was performed to examine the expression of Galectin-9 in paraffin-embedded tissues from 140 cases of HBV-associated HCC specimens.	Paraffin	96-104	galectin 9	Homo sapiens	82-92
35228756-11	2022	Furthermore, the performance of Idylla  EGFR Mutation Test and Qiagen Therascreen  EGFR RGQ PCR on archived paraffin sections of limited quantities is available with the high agreement of results.	Paraffin	108-116	epidermal growth factor receptor	Homo sapiens	83-87
35481563-4	2022	Materials and methods: We analyzed the expression of CB1R in 61 paraffin-embedded glioma and 4 normal brain tissues using automated immunohistochemical assay.	Paraffin	64-72	cannabinoid receptor 1	Homo sapiens	53-57
35017170-5	2022	Semaphorin 3B antigen was detected in immune deposits by immunohistochemistry and confocal microscopy on paraffin-embedded biopsies.	Paraffin	105-113	semaphorin 3B	Homo sapiens	0-13
35043182-6	2022	Coexpression of StSN2 and StGAPC1 in bud eyes and apical buds was verified by immunofluorescence analysis of paraffin sections.	Paraffin	109-117	snakin-2	Solanum tuberosum	16-21
35223984-2	2021	Objective: The aim of this study was to search the prognostic biomarkers of EOC and to investigate the expression of G protein-coupled receptor kinase 5 (GRK5) and actin alpha cardiac muscle 1 (ACTC1) in EOC tissues (both paraffin-embedded and fresh-frozen tissues) and to explore their association with clinicopathological parameters and prognostic value in patients with EOC.	Paraffin	222-230	G protein-coupled receptor kinase 5	Homo sapiens	117-152
35223984-2	2021	Objective: The aim of this study was to search the prognostic biomarkers of EOC and to investigate the expression of G protein-coupled receptor kinase 5 (GRK5) and actin alpha cardiac muscle 1 (ACTC1) in EOC tissues (both paraffin-embedded and fresh-frozen tissues) and to explore their association with clinicopathological parameters and prognostic value in patients with EOC.	Paraffin	222-230	G protein-coupled receptor kinase 5	Homo sapiens	154-158
35223984-2	2021	Objective: The aim of this study was to search the prognostic biomarkers of EOC and to investigate the expression of G protein-coupled receptor kinase 5 (GRK5) and actin alpha cardiac muscle 1 (ACTC1) in EOC tissues (both paraffin-embedded and fresh-frozen tissues) and to explore their association with clinicopathological parameters and prognostic value in patients with EOC.	Paraffin	222-230	actin alpha cardiac muscle 1	Homo sapiens	164-192
35223984-2	2021	Objective: The aim of this study was to search the prognostic biomarkers of EOC and to investigate the expression of G protein-coupled receptor kinase 5 (GRK5) and actin alpha cardiac muscle 1 (ACTC1) in EOC tissues (both paraffin-embedded and fresh-frozen tissues) and to explore their association with clinicopathological parameters and prognostic value in patients with EOC.	Paraffin	222-230	actin alpha cardiac muscle 1	Homo sapiens	194-199
35159076-4	2022	We assessed the immunohistochemical levels of AKR1B1 and AKR1B10 in tissue paraffin sections from 99 patients with high-grade serous ovarian cancer (HGSC) and compared these levels with clinicopathological characteristics, survival, and response to chemotherapy.	Paraffin	75-83	aldo-keto reductase family 1 member B	Homo sapiens	46-52
35545361-5	2022	This study aims to evaluate the consistency of EGFR mutant gene expression between the 2 methods, and to explore a reliable way for preserving cytological data and making full use of cytological archival data via cell HE staining smear and cell paraffin section.	Paraffin	245-253	epidermal growth factor receptor	Homo sapiens	47-51
35545361-10	2022	EGFR gene mutation was detected by amplification refractory mutation system-polymerase chain reaction in 57 paired cell HE staining smears and cell paraffin sections.	Paraffin	148-156	epidermal growth factor receptor	Homo sapiens	0-4
2475778-3	1989	We retrospectively examined the association between the expression of Hpr and the recurrence of cancer in 70 patients with early breast cancer (Stage I or II) treated by mastectomy from 1977 through 1985, using immunohistochemical analysis of routinely processed paraffin-embedded tissue and evaluating it without knowledge of the patients" status.	Paraffin	263-271	haptoglobin-related protein	Homo sapiens	70-73
2675623-0	1989	Immunocytochemical staining of progesterone receptor in paraffin sections of human breast cancers.	Paraffin	56-64	progesterone receptor	Homo sapiens	31-52
2675623-3	1989	Six could detect PR in paraffin sections, with Li 417, LET 456, and LET 126 giving the best results.	Paraffin	23-31	progesterone receptor	Homo sapiens	17-19
2675623-11	1989	Weaker intensity and fewer number of PR-positive cells were found for paraffin-embedded tumors.	Paraffin	70-78	progesterone receptor	Homo sapiens	37-39
2675623-13	1989	In conclusion, this immunocytochemical method for detection of PR and ER on paraffin sections offers an alternative to frozen tissue.	Paraffin	76-84	progesterone receptor	Homo sapiens	63-65
34972731-3	2022	PATIENTS AND METHODS: This study analysed the protein expression of p16 in 202 paraffin blocks from Sudanese women with breast cancer using immunohistochemistry.	Paraffin	79-87	cyclin dependent kinase inhibitor 2A	Homo sapiens	68-71
2772896-7	1989	In paraffin sections six of 16 cases expressed epithelial membrane antigen (EMA).	Paraffin	3-11	mucin 1, cell surface associated	Homo sapiens	47-80
2772896-9	1989	The EMA reactivity was of nearly equal intensity in paraffin and frozen sections, while the reactivity of LCA and Ber-H2 was significantly reduced in paraffin sections, implying only partial preservation of the antigens.	Paraffin	52-60	mucin 1, cell surface associated	Homo sapiens	4-7
2477988-2	1989	The alpha subunit of human chorionic gonadotropin (HCG) was localized Immunohistochemically in paraffin sections of normal human tissues and neuroendocrine tumors.	Paraffin	95-103	chorionic gonadotropin subunit beta 5	Homo sapiens	4-55
2682614-0	1989	Immunocytochemical assay of progesterone receptors in paraffin-embedded specimens of endometrial carcinoma and hyperplasia: a preliminary evaluation.	Paraffin	54-62	progesterone receptor	Homo sapiens	28-50
2524457-6	1989	The immunoreactivity of Ca2+-ATPase and myoglobin were well preserved after fixation of the muscles in Bouin"s solution, or in formol/acetic acid fixative, and paraffin embedding.	Paraffin	160-168	myoglobin	Rattus norvegicus	40-49
2517130-2	1989	FVIII/vWF Ag was localized clearly in the tissue fixed with various common fixatives and embedded in paraffin without enzyme treatment.	Paraffin	101-109	coagulation factor VIII	Homo sapiens	0-5
2682614-1	1989	An immunohistochemical method for the detection of progesterone receptors (PgR) using the monoclonal anti-PgR antibody KD 68 was utilized to study paraffin-embedded tissue sections from women with endometrial carcinoma and hyperplasia.	Paraffin	147-155	progesterone receptor	Homo sapiens	51-73
2830712-11	1988	EMA was detected effectively in paraffin-embedded sections.	Paraffin	32-40	mucin 1, cell surface associated	Homo sapiens	0-3
2682614-1	1989	An immunohistochemical method for the detection of progesterone receptors (PgR) using the monoclonal anti-PgR antibody KD 68 was utilized to study paraffin-embedded tissue sections from women with endometrial carcinoma and hyperplasia.	Paraffin	147-155	progesterone receptor	Homo sapiens	75-78
2732347-3	1989	B19-DNA was detectable in paraffin wax embedded fetal tissue from the liver, heart, lung, brain and thymus.	Paraffin	26-38	eva-1 homolog C	Homo sapiens	0-3
3613527-1	1987	MAM-6 antigen is detectable in a large variety of formalin fixed and paraffin embedded normal and neoplastic tissues throughout the body with some exceptions.	Paraffin	69-77	mucin 1, cell surface associated	Homo sapiens	0-5
2461928-8	1987	In both plastic and paraffin sections, pretreatment with neuraminidase enhanced the sensitivity of Leu-M1 reactivity, but markedly decreased its specificity.	Paraffin	20-28	neuraminidase 1	Homo sapiens	57-70
2703136-11	1989	A satisfactory validity can be obtained today through the development of highly specific monoclonal antibodies against the progesterone receptor complex, with the complete receptor diagnosis of mammary carcinoma both immunocytochemically in frozen sections and additionally, of progesterone receptors in paraffin wax sections.	Paraffin	304-316	progesterone receptor	Homo sapiens	123-144
3068893-1	1988	Anti-rat myoglobin (Mb) was prepared and used in the avidin-biotin-peroxidase complex (ABC) method on paraffin-embedded sections of nine soft tissue tumors (including two rhabdomyosarcomas) of rats.	Paraffin	102-110	myoglobin	Rattus norvegicus	20-22
3276207-10	1988	The HECA-452 antigen is preserved in paraffin sections of sublimate formaldehyde- and also routinely formalin-fixed tissues.	Paraffin	37-45	hdc homolog, cell cycle regulator	Homo sapiens	4-8
2892311-5	1987	Thus our retrospective investigation of routinely processed and paraffin-embedded trephine biopsies shows that the diagnosis of a megakaryoblastic crisis in CML as well as AM may be easily established with the aid of the anti-factor VIII method.	Paraffin	64-72	cytochrome c oxidase subunit 8A	Homo sapiens	233-237
2492243-2	1989	We have determined the spatial pattern of beta 3-tubulin expression by localizing the beta 3 mRNA in paraffin sections using a 3" message-specific RNA probe and by localizing the beta 3 protein using a polyclonal antibody specific for Drosophila beta 3-tubulin.	Paraffin	101-109	beta-Tubulin at 60D	Drosophila melanogaster	42-56
3312298-5	1987	A recent promising development has therefore been the demonstration that polyclonal antisera raised against the CD3/T3 T cell specific marker (purified by affinity chromatography) are suitable for staining T cells in paraffin sections.	Paraffin	217-225	CD3 antigen, epsilon polypeptide	Mus musculus	112-115
2465399-0	1988	Distinction between hepatocellular carcinoma, cholangiocarcinoma, and metastatic carcinoma based on immunohistochemical staining for carcinoembryonic antigen and for cytokeratin 19 on paraffin sections.	Paraffin	184-192	keratin 19	Homo sapiens	166-180
3539312-1	1987	The effectiveness of an immunoperoxidase technique using four monoclonal antibodies (mAb) is compared to a technique using one polyclonal antibody (pAb) to detect human thyroglobulin (Tg) in paraffin sections of 55 thyroid carcinomas.	Paraffin	191-199	thyroglobulin	Homo sapiens	169-182
3539312-1	1987	The effectiveness of an immunoperoxidase technique using four monoclonal antibodies (mAb) is compared to a technique using one polyclonal antibody (pAb) to detect human thyroglobulin (Tg) in paraffin sections of 55 thyroid carcinomas.	Paraffin	191-199	thyroglobulin	Homo sapiens	184-186
3543065-1	1986	The aspartic proteinase cathepsin D was purified from human spleen and localised in various formalin fixed paraffin embedded human tissues using the peroxidase-antiperoxidase (PAP) technique.	Paraffin	107-115	cathepsin D	Homo sapiens	24-35
3454079-0	1987	Detection of histidine decarboxylase (HDC) in paraffin sections of formalin fixed rat stomach using avidin-biotin-peroxidase-complex method.	Paraffin	46-54	histidine decarboxylase	Rattus norvegicus	13-36
3537539-3	1986	Specific binding of swine immune serum against luteinizing hormone-releasing hormone has been detected with the protein A-biotin-streptavidin method employed on paraffin and vibratome sections of fetal and postnatal pig hypothalamus.	Paraffin	161-169	gonadotropin releasing hormone 1	Sus scrofa	47-84
2993153-2	1985	With commercially available monoclonal antibodies and an indirect immunoperoxidase technique, EMA localization was evaluated in paraffin-embedded tissues from a wide variety of neoplasms (320 specimens).	Paraffin	128-136	mucin 1, cell surface associated	Homo sapiens	94-97
3454079-0	1987	Detection of histidine decarboxylase (HDC) in paraffin sections of formalin fixed rat stomach using avidin-biotin-peroxidase-complex method.	Paraffin	46-54	histidine decarboxylase	Rattus norvegicus	38-41
3454079-7	1987	Therefore, ABC method of HDC is thought to be a useful technique for the detection of enterochromaffin-like cells using paraffin sections.	Paraffin	120-128	histidine decarboxylase	Rattus norvegicus	25-28
2988710-2	1985	In paraffin sections from the brains of 60-day-old rats 5"-nucleotidase immunoreactivity occurred in the same white-matter regions as myelin-basic protein immunoreactivity and histological staining of myelin.	Paraffin	3-11	5' nucleotidase, ecto	Rattus norvegicus	56-71
2988710-4	1985	In the paraffin sections from the brains of younger (20-day-old) rats the staining of 5"-nucleotidase in the white matter was faint and patchy.	Paraffin	7-15	5' nucleotidase, ecto	Rattus norvegicus	86-101
2988710-5	1985	In paraffin sections from spinal cord, 5"-nucleotidase immunoreactivity was observed throughout the lateral white-matter columns and, frequently, in the cell bodies of interfascicular oligodendroglia.	Paraffin	3-11	5' nucleotidase, ecto	Rattus norvegicus	39-54
3128050-6	1987	Expression of immunohistochemically detectable EMA in paraffin sections suggests the antigen to be useful as a new marker of salivary gland function, of either acinar compartments or ductal segments.	Paraffin	54-62	mucin 1, cell surface associated	Homo sapiens	47-50
6084247-1	1984	The immunoperoxidase technique was used to study the localization of pregnancy-associated plasma protein A (PAPP-A) in formaldehyde-fixed paraffin-embedded tissue from normal human placentae at the gestational age of 8, 15 and 40 weeks.	Paraffin	138-146	pappalysin 1	Homo sapiens	69-106
3988245-9	1985	Mucin stains on routine fixed paraffin-embedded tissue provide a simple screening method to sharpen the assessment of dysplasia and cancer-risk in patients with ulcerative colitis despite the limitations referred to above.	Paraffin	30-38	LOC100508689	Homo sapiens	0-5
6375461-1	1984	The immunohistochemical localization of luteinizing hormone-releasing hormone (LHRH) was studied in paraffin and vibratome-sectioned tissue from adult female hamsters that were treated neonatally with monosodium glutamate (MSG) or hypertonic saline.	Paraffin	100-108	gonadotropin releasing hormone 1	Homo sapiens	40-77
6084247-1	1984	The immunoperoxidase technique was used to study the localization of pregnancy-associated plasma protein A (PAPP-A) in formaldehyde-fixed paraffin-embedded tissue from normal human placentae at the gestational age of 8, 15 and 40 weeks.	Paraffin	138-146	pappalysin 1	Homo sapiens	108-114
6375461-1	1984	The immunohistochemical localization of luteinizing hormone-releasing hormone (LHRH) was studied in paraffin and vibratome-sectioned tissue from adult female hamsters that were treated neonatally with monosodium glutamate (MSG) or hypertonic saline.	Paraffin	100-108	gonadotropin releasing hormone 1	Homo sapiens	79-83
3531106-2	1986	The immunohistochemical localization of neuropeptide Y (NPY) was correlated with those of dopamine-beta-hydroxylase (DBH) and vasoactive intestinal polypeptide (VIP) by mapping serial 7 micron paraffin sections at three levels of the guinea pig lower brainstem: a) area postrema, b) dorsal motor nucleus of the vagus, and c) nucleus prepositus of the hypoglossal nerve.	Paraffin	193-201	VIP peptides	Cavia porcellus	161-164
6375461-2	1984	There appeared to be a reduction in LHRH-positive fibers in the median eminence of animals with an MSG-induced lesion of the arcuate nucleus in paraffin-embedded tissue.	Paraffin	144-152	gonadotropin releasing hormone 1	Homo sapiens	36-40
6363816-2	1984	Utilizing an immunofluorescence procedure for the cellular and extracellular localization of eosinophil MBP in formalin-fixed, paraffin-embedded tissues, we studied skin biopsies from onchocerciasis patients before and during treatment with topically or orally administered DEC. Before DEC, there was little or no inflammatory response in either dermis or epidermis and microfilariae were essentially intact.	Paraffin	127-135	myelin basic protein	Homo sapiens	104-107
6367693-6	1984	Moreover, measurement of the feature "maximal nuclear diameter" on paraffin sections from 42 further cases showed the possibility of morphometric discrimination of low and high malignant NHL in histopathological diagnostics.	Paraffin	67-75	regulator of telomere elongation helicase 1	Homo sapiens	187-190
7394510-1	1980	Two methods for extraction and determination of benzo[a]pyrene and other PAH in liquid and white soft paraffins, widely used for medicinal and cosmetic purposes, are compared.	Paraffin	102-111	phenylalanine hydroxylase	Homo sapiens	73-76
6164245-1	1981	The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas.	Paraffin	136-144	pappalysin 1	Homo sapiens	67-103
6164245-1	1981	The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas.	Paraffin	136-144	pappalysin 1	Homo sapiens	105-111
5339392-0	1966	Histochemical demonstration of beta-glucuronidase and N-Acetyl-beta-glucosaminidase on paraffin section using naphthol AS substrates.	Paraffin	87-95	glucuronidase beta	Homo sapiens	31-49
6801111-1	1982	The immunohistochemical detection of factor VIII/von Willebrand factor antigen (FVIII/vWF-AG) in formalin-fixed paraffin-embedded tissues was investigated using the peroxidase-antiperoxidase (PAP) method.	Paraffin	112-120	coagulation factor VIII	Homo sapiens	80-85
5339392-0	1966	Histochemical demonstration of beta-glucuronidase and N-Acetyl-beta-glucosaminidase on paraffin section using naphthol AS substrates.	Paraffin	87-95	O-GlcNAcase	Homo sapiens	54-83
7030457-7	1981	The distribution of LHRH immunoreactivity was determined by immunocytochemical procedures on Bouin"s fixed, paraffin-embedded brain sections.	Paraffin	108-116	progonadoliberin-1	Cavia porcellus	20-24
33839437-4	2021	The cD1 status (gene amplified/nonamplified) was determined on formalin-fixed paraffin-embedded tumor tissue sections by chromogenic in situ hybridization.	Paraffin	78-86	cyclin D1	Homo sapiens	4-7
14934016-0	1952	The use of paraffin as an aid in obliterating the pleural space following total pneumonectomy.	Paraffin	11-19	activation induced cytidine deaminase	Homo sapiens	26-29
6166655-1	1981	Immunocytochemical localization of neuropeptides such as luteinizing hormone-releasing hormone (LHRH) is generally performed on Bouin"s fixed tissue sections, following tissue dehydration in alcohols and embedment in paraffin.	Paraffin	217-225	gonadotropin releasing hormone 1	Homo sapiens	57-94
33368602-4	2021	METHODS/RESULTS: Expression of MUC4 was assessed by immunohistochemistry in a total of 97 rhabdomyosarcomas using formalin-fixed paraffin-embedded tissue sections.	Paraffin	129-137	mucin 4, cell surface associated	Homo sapiens	31-35
33840146-9	2021	Next-generation sequencing studies (sarcoma gene fusion NGS panel with subsequent Sanger confirmation) performed on formalin-fixed paraffin-embedded tissue detected a fusion product between MEAF6 exon 4 (NM_001270875) and SUZ12 exon 2 (NM_001321207.1).	Paraffin	131-139	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	222-227
33689055-4	2021	RESULTS: TIP was detected by immunohistochemical staining of CD138 in the paraffin-embedded specimen after surgery in the discovery set and was validated by using an established computational algorithm in the GEO and TCGA sets.	Paraffin	74-82	syndecan 1	Homo sapiens	61-66
6166655-1	1981	Immunocytochemical localization of neuropeptides such as luteinizing hormone-releasing hormone (LHRH) is generally performed on Bouin"s fixed tissue sections, following tissue dehydration in alcohols and embedment in paraffin.	Paraffin	217-225	gonadotropin releasing hormone 1	Homo sapiens	96-100
7012361-0	1980	One micrometre paraffin sections: an aid to interpretation of immunoperoxidase staining of immunoglobulins.	Paraffin	15-23	activation induced cytidine deaminase	Homo sapiens	37-40
33677883-3	2021	The protein expression of LEF1 and TdT was detected by immunohistochemistry in 53 paraffin-embedded tissue samples of LBL/ALL.	Paraffin	82-90	lymphoid enhancer binding factor 1	Homo sapiens	26-30
1033009-6	1976	The single-cell protein (SCP) products obtaine on different substrates (paraffins, alcohols or inorganic substrates) are evaluated as regards their general composition, amino acid content and nutritive value.	Paraffin	72-81	urocortin 3	Homo sapiens	25-28
33519444-4	2020	Protein expression of IQGAP3 was also evaluated immunohistochemically in archived paraffin-embedded specimens from 257 breast cancer patients, and the associations between IQGAP3 expression level, clinical characteristics, and prognosis were analyzed.	Paraffin	82-90	IQ motif containing GTPase activating protein 3	Homo sapiens	22-28
33519444-7	2020	Additionally, high levels of IQGAP3 expression were detected in 110/257 (42.8%) of archived paraffin-embedded breast cancer specimens.	Paraffin	92-100	IQ motif containing GTPase activating protein 3	Homo sapiens	29-35
33385586-4	2021	We report development of a qRT-PCR-based Lymphoma cell-of-origin (LCOO) assay to determine ABC, GCB, and Unclassifiable (UC) subtypes in formalin-fixed, paraffin embedded tissue (FFPET) DLBCL samples.	Paraffin	153-161	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	91-94
33562537-3	2021	EG and CS can carry 90 and 40 wt.% paraffin, respectively.	Paraffin	35-43	citrate synthase	Homo sapiens	7-9
34050137-4	2021	Using 150 formalin-fixed and paraffin-embedded samples and 8 fresh samples, we found high PNO1 expression in HCC tumor tissues through Western blotting and RT-PCR.	Paraffin	29-37	partner of NOB1 homolog	Homo sapiens	90-94
33341705-4	2021	CCND1 amplification was examined in paraffin-embedded skin biopsies and excisions using a dual-probes fluorescence in situ hybridization (FISH) (11q13 and CEP11).	Paraffin	36-44	cyclin D1	Homo sapiens	0-5
33270750-4	2020	ALCAM expression in 45 patients with MB was evaluated by immunohistochemical analysis of formalin-fixed paraffin-embedded clinical specimens and the relationship between ALCAM expression and pathological type/molecular subgroup, such as WNT, SHH, Group 3, and Group 4, was examined.	Paraffin	104-112	activated leukocyte cell adhesion molecule	Homo sapiens	0-5
33457012-6	2020	Methods: Expression of CLDN18.2 in 105 formalin-fixed, paraffin-embedded (FFPE) tumor tissues was detected by immunohistochemistry (IHC) and evaluated according to FAST criteria.	Paraffin	55-63	claudin 18	Homo sapiens	23-29
34049150-4	2021	Moreover, the levels of RAD54B in paraffin-embedded samples were evaluated using immunohistochemistry (IHC).	Paraffin	34-42	RAD54 homolog B	Homo sapiens	24-30
33024003-6	2020	Protein levels of ACE2 were visualized by immunohistochemistry on paraffin-embedded lung tissue samples and quantified in alveolar and bronchial epithelium.	Paraffin	66-74	angiotensin converting enzyme 2	Homo sapiens	18-22
33890816-5	2021	Here, we tested several commercially available serological reagents and identified a monoclonal antibody suitable for the immunohistochemical detection of PRAME in formalin-fixed paraffin-embedded specimens.	Paraffin	179-187	PRAME nuclear receptor transcriptional regulator	Homo sapiens	155-160
32802162-5	2020	Immunohistochemical staining for HER3 was performed on formalin-fixed paraffin-embedded surgical specimens.	Paraffin	70-78	erb-b2 receptor tyrosine kinase 3	Homo sapiens	33-37
33037736-3	2020	Evaluation of formalin-fixed paraffin-embedded (FFPE) and frozen tissues of adenomas and CRCs, along with their corresponding normal samples, showed that TRIP13 was gradually increased in its phenotypic expression from adenoma to carcinoma, and that its overexpression in CRCs was independent of patient"s gender, age, race/ethnicity, pathologic stage, and p53 and microsatellite instability (MSI) status.	Paraffin	29-37	thyroid hormone receptor interactor 13	Homo sapiens	154-160
33123247-3	2020	Immunohistochemical staining for HER3 was performed using formalin-fixed paraffin-embedded surgical specimens and biopsy samples.	Paraffin	73-81	erb-b2 receptor tyrosine kinase 3	Homo sapiens	33-37
32711549-4	2020	METHODS: Immunohistochemistry (IHC) was conducted to assess the expression of Sirt6 on paraffin-embedded tissues.	Paraffin	87-95	sirtuin 6	Homo sapiens	78-83
33687169-6	2021	Materials and Methods: In this experimental study, localization of Flk-1/KDR was investigated by immunohistochemistry and immunofluorescence techniques, in paraffin embedded tissue sections.	Paraffin	156-164	kinase insert domain protein receptor	Mus musculus	67-72
32733643-5	2020	Marker potential of S100A8 and S100A9 was confirmed by immunohistochemistry of paraffin-embedded pathological samples.	Paraffin	79-87	S100 calcium binding protein A8	Homo sapiens	20-26
33687169-6	2021	Materials and Methods: In this experimental study, localization of Flk-1/KDR was investigated by immunohistochemistry and immunofluorescence techniques, in paraffin embedded tissue sections.	Paraffin	156-164	kinase insert domain protein receptor	Mus musculus	73-76
33679132-2	2021	Methods: The expression of HSF1 in 110 paraffin-embedded cervical cancer sections of different grades was examined via immunohistochemistry analyses.	Paraffin	39-47	heat shock transcription factor 1	Homo sapiens	27-31
32314446-0	2020	Combination of KRAS and SMAD4 mutations in formalin-fixed paraffin-embedded tissues as a biomarker for pancreatic cancer.	Paraffin	58-66	SMAD family member 4	Homo sapiens	24-29
33176814-3	2020	METHOD: We investigated the expression of KPNA2 protein by immunohistochemistry on paraffin-embedded surgical specimens from 223 patients with malignant and benign bone tumors, including 81 osteosarcomas, 42 chondrosarcomas, 15 ESs, 28 osteoid osteomas, 20 osteochondromas and 37 chondroblastomas.	Paraffin	83-91	karyopherin subunit alpha 2	Homo sapiens	42-47
33552282-4	2021	Immunohistochemistry was used to retrospectively examine the expression levels of AMPK and TET2 in paraffin-embedded specimens obtained from 343 patients with CRC.	Paraffin	99-107	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	82-86
33109151-9	2020	Immunological tests in paraffin section also confirmed that up-regulation of FAP was present in advanced stage HGSOC patients.	Paraffin	23-31	fibroblast activation protein alpha	Homo sapiens	77-80
32028329-3	2020	METHODS: Immunofluorescence for TLR3, TLR4, and TLR9 on paraffin embedded biopsies from uninfected, viremic, immune success, and immune failure colons was imaged by deconvolution microscopy and quantified with MetaMorph software.	Paraffin	56-64	toll like receptor 3	Homo sapiens	32-36
32028329-3	2020	METHODS: Immunofluorescence for TLR3, TLR4, and TLR9 on paraffin embedded biopsies from uninfected, viremic, immune success, and immune failure colons was imaged by deconvolution microscopy and quantified with MetaMorph software.	Paraffin	56-64	toll like receptor 9	Homo sapiens	48-52
33500629-4	2021	Next-generation sequencing performed on paraffin sections of the postoperative tumor samples indicated the presence of the ERBB3 V104L mutation.	Paraffin	40-48	erb-b2 receptor tyrosine kinase 3	Homo sapiens	123-128
32202907-5	2020	We first found that in formalin-fixed, paraffin-embedded (FFPE) malignant lung samples, 90% (28/31) had increased SHOX2 and/or PTGER4 promoter methylation as compared with their adjacent non-malignant samples.	Paraffin	39-47	short stature homeobox 2	Homo sapiens	114-119
32138807-4	2020	Expression of EIF5A2protein were analyzed in paraffin-embedded human ATC tissues and adjacent nontumorous tissues(ANCT) (n=24) by immunochemistry.	Paraffin	45-53	eukaryotic translation initiation factor 5A2	Homo sapiens	14-20
33433416-2	2021	Aim: To validate the diagnosis made by morphology and immunohistochemistry (IHC) by fluorescence in-situ hybridization (FISH) for EWSR1 rearrangement on formalin fixed paraffin embedded (FFPE) tissues.	Paraffin	168-176	EWS RNA binding protein 1	Homo sapiens	130-135
32867667-6	2021	METHOD: The immunohistochemical expression of KMT2C/MLL3, H3K4me2 and H3K4me3 was analyzed in formalin fixed paraffin embedded tissue from 96 patients with lung adenocarcinoma.	Paraffin	109-117	lysine methyltransferase 2C	Homo sapiens	46-51
32314796-9	2020	CXCR4 and MMP-2 proteins in tumor tissues were detected by immunohistochemistry on paraffin-embedded tissue sections.	Paraffin	83-91	matrix metallopeptidase 2	Homo sapiens	10-15
31529315-4	2020	Protein expression of phosphorylated CDK2 (p-CDK2) in paraffin-embedded tissue specimens of ACC from 17 patients was investigated by immunohistochemistry (IHC).	Paraffin	54-62	cyclin dependent kinase 2	Homo sapiens	37-41
31529315-4	2020	Protein expression of phosphorylated CDK2 (p-CDK2) in paraffin-embedded tissue specimens of ACC from 17 patients was investigated by immunohistochemistry (IHC).	Paraffin	54-62	cyclin dependent kinase 2	Homo sapiens	45-49
33683681-6	2021	Here we describe an automated IHC protocol used in our laboratory for the detection of TTF-1 in formalin-fixed, paraffin-embedded (FFPE) tissue sections from lung tumors.	Paraffin	112-120	transcription termination factor 1	Homo sapiens	87-92
33269348-5	2020	In a subset of this cohort we validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry.	Paraffin	100-108	angiotensin converting enzyme 2	Homo sapiens	40-44
32362707-9	2020	Our study suggests while GAN is able to attain formalin fixed and paraffin embedded tissue image quality, GAN requires further prior knowledge as input to model intrinsic micro-anatomical details, such as capillary wall, urinary pole, nuclei placement, suggesting developing semi-supervised architectures by using these above details as prior information.	Paraffin	66-74	gigaxonin	Homo sapiens	25-28
32534365-3	2020	METHOD AND RESULTS: We examined 86 thyroid lymphoma cases using fluorescence in situ hybridization (FISH) for the detection of t(3;14)/FOXP1-IGH in formalin fixed paraffin-embedded tissue (FFPE).	Paraffin	163-171	immunoglobulin heavy locus	Homo sapiens	141-144
33042836-2	2020	Methods: Using immunohistochemistry, the expression of B7-H3 was detected in a total of 213 formalin-fixed paraffin-embedded CRC tissue specimens.	Paraffin	107-115	CD276 molecule	Homo sapiens	55-60
32428030-5	2020	Immunohistochemical analysis of a comprehensive set of tissue microarrays comprising over 1,200 formalin-fixed, paraffin-embedded tissue cores from human epithelial tumors and inflammatory disease confirmed that NOX1 is overexpressed in human colon and small intestinal adenocarcinomas, as well as adenomatous polyps, compared to adjacent, uninvolved intestinal mucosae.	Paraffin	112-120	NADPH oxidase 1	Homo sapiens	212-216
31338584-4	2019	Light microscopic and fluorescence immunolabeling in paraffin-embedded murine ES tissue sections (male C57BL/6 mice, 6-8 weeks old) demonstrated the presence of the calcium-sensing receptor CaSR, transient receptor potential cation channel subtypes TRPV5 and TRPV6, sarco/endoplasmic reticulum Ca2+-ATPases SERCA1 and SERCA2, Na+/Ca2+ exchanger NCX2, and plasma membrane Ca2+ ATPases PMCA1 and PMCA4 in ES epithelial cells.	Paraffin	53-61	calcium-sensing receptor	Mus musculus	190-194
31261288-4	2019	We designed, optimized, and validated a dual-color TCF4/CD123 immunohistochemistry stain for use in formalin-fixed paraffin-embedded tissue sections.	Paraffin	115-123	transcription factor 4	Homo sapiens	51-55
32847623-2	2020	This study aimed at investigating the immunohistochemical expression of PAX-8 among Sudanese females diagnosed with cervical, endometrial, and ovarian cancers between December 2017 and May 2019 by studying their Formalin-fixed paraffin embedded blocks.	Paraffin	227-235	paired box 8	Homo sapiens	72-77
31261288-4	2019	We designed, optimized, and validated a dual-color TCF4/CD123 immunohistochemistry stain for use in formalin-fixed paraffin-embedded tissue sections.	Paraffin	115-123	interleukin 3 receptor subunit alpha	Homo sapiens	56-61
31492174-11	2019	Immunohistochemical staining of greater than 50% of tumor nuclei on formalin-fixed paraffin-embedded tissue using the monoclonal rabbit antibody to NUT (clone C52B1), has a specificity of 100%, and sensitivity of 87% for the diagnosis of NUT midline carcinoma.	Paraffin	83-91	NUT midline carcinoma family member 1	Homo sapiens	148-151
31260927-1	2019	Very short-chain chlorinated paraffins (vSCCPs, C6-9) occurred in 94% of wildlife samples from the Yangtze River Delta (YRD), China, with CnClm comparable to that of a local CP product, CP-52.	Paraffin	29-38	complement C6	Homo sapiens	48-52
32458628-9	2020	CONCLUSION: Optimised Dako FISH protocol was noted to be more suited for detecting SYT-SSX FISH signals on paraffin embedded tissues in comparison to Cytocell FISH protocol.	Paraffin	107-115	synaptotagmin 1	Homo sapiens	83-86
31535357-5	2020	All patients were analyzed for SAMD9 gene mutation using paraffin-embedded tumoral calcinosis specimens.	Paraffin	57-65	sterile alpha motif domain containing 9	Homo sapiens	31-36
32449514-6	2020	SOAT1 protein expression was determined by immunohistochemistry on formalin-fixed paraffin-embedded specimens.	Paraffin	82-90	sterol O-acyltransferase 1	Homo sapiens	0-5
31125781-5	2019	The expression of TGF-alpha and Ki-67 were detected by immunohistochemical staining of paraffin-embedded patient tissue specimens.	Paraffin	87-95	transforming growth factor alpha	Homo sapiens	18-27
32691176-8	2020	Furthermore, the presence of SS18-SSX2 fusion transcripts was confirmed by reverse transcription-polymerase chain reaction analysis, using a paraffin-embedded tumor specimen.	Paraffin	141-149	SSX family member 2	Homo sapiens	34-38
32064493-4	2020	METHODS: Functional characterization of the NOX1 variant included ROS generation, wound healing, 2-dimensional collective chemotactic migration, single-cell planktonic migration in heterologous cell lines, and RNA scope and immunohistochemistry of paraffin-embedded patient tissue samples.	Paraffin	248-256	NADPH oxidase 1	Homo sapiens	44-48
31069614-7	2019	Moreover, we found a 50-fold upregulation of FBLN2 gene expression in paraffin-embedded tissues compared with the enriched epithelial cells of peripheral blood lymphocytes of patients.	Paraffin	70-78	fibulin 2	Homo sapiens	45-50
30955082-5	2019	LLT1 expression was analyzed on paraffin-embedded tissue samples obtained from 100 patients with cSCC by immunohistochemistry.	Paraffin	32-40	C-type lectin domain family 2 member D	Homo sapiens	0-4
32176632-1	2020	OBJECTIVE: LGR4 expression in serous ovarian cancer paraffin-embedded tissues and fresh tissues were investigated, and its expression associated with clinicopathological parameters and prognosis in serous ovarian cancer was explored.	Paraffin	52-60	leucine rich repeat containing G protein-coupled receptor 4	Homo sapiens	11-15
32176632-4	2020	RESULTS: LGR4 expression was much higher both in paraffin-embedded and fresh cancer tissues than that in paratumor tissues, respectively, and its expression was associated with recurrence free survival and overall survival in serous ovarian cancer patients.	Paraffin	49-57	leucine rich repeat containing G protein-coupled receptor 4	Homo sapiens	9-13
31638234-0	2019	Development of recurrence risk score using 95-gene classifier and its application to formalin-fixed paraffin-embedded tissues in ER-positive, HER2-negative and node-negative breast cancer.	Paraffin	100-108	epiregulin	Homo sapiens	129-131
31754355-5	2019	Methods: The occludin mRNA level was compared between paraffin-embedded tissues of 40 patients with melanoma and 10 subjects with normal skin.	Paraffin	54-62	occludin	Homo sapiens	13-21
32714079-5	2020	The FLAD1 protein expression were detected in 106 paraffin-embedded GC tissues by immunohistochemistry (IHC).	Paraffin	50-58	flavin adenine dinucleotide synthetase 1	Homo sapiens	4-9
31313968-2	2019	Therefore, sensitive and specific monoclonal antibodies detecting PDPN are necessary for immunohistochemical analyses, especially using formalin-fixed paraffin-embedded tissues.	Paraffin	151-159	podoplanin	Homo sapiens	66-70
30890279-6	2019	Arg-1 expression levels were determined in paraffin-embedded CRC tissue specimens (n = 236) by immunohistochemistry.	Paraffin	43-51	arginase 1	Homo sapiens	0-5
32377713-11	2020	Furthermore, alpha2M pretreatment suppressed the expression of 8-hydroxy-2"-deoxyguanosine in mandibular bone and tongue paraffin embedded sections, which is a marker of oxidative damage, and increased SOD2 expression in mucosa and tongue paraffin embedded sections.	Paraffin	121-129	alpha-2-macroglobulin	Rattus norvegicus	13-20
31011147-3	2019	MATERIAL AND METHODS: A retrospective descriptive study of the immunohistochemical expression of CCR4, CCR5, CCR7 and CXCR4 in paraffin-embedded samples of 124 patients with SCC of the tongue and floor of the mouth was performed, considering 98 cases from Brazil and 26 cases from Chile.	Paraffin	127-135	C-C motif chemokine receptor 4	Homo sapiens	97-101
31079917-4	2019	Immunohistochemistry (IHC) analysis was used to examine DLL3 expression in paraffin-embedded SCLC tumor samples.	Paraffin	75-83	LOC105375808	Homo sapiens	56-60
32377713-11	2020	Furthermore, alpha2M pretreatment suppressed the expression of 8-hydroxy-2"-deoxyguanosine in mandibular bone and tongue paraffin embedded sections, which is a marker of oxidative damage, and increased SOD2 expression in mucosa and tongue paraffin embedded sections.	Paraffin	239-247	alpha-2-macroglobulin	Rattus norvegicus	13-20
32157438-4	2020	METHODS: Immunohistochemical analysis was obtained to quantify RIP140 and LCoR expression in formalin-fixed paraffin embedded tissue sections of cervical intraepithelial neoplasia samples.	Paraffin	108-116	nuclear receptor interacting protein 1	Homo sapiens	63-69
32606792-3	2020	Materials and Methods: Quantitative real-time PCR and Western blot analysis were used to analyze the expression of TMED3 mRNA and protein in 182 paraffin-embedded primary breast cancer tissues and 60 paired noncancerous tissues and 25 fresh primary breast cancer tissues and surrounding adjacent noncancerous tissues.	Paraffin	145-153	transmembrane p24 trafficking protein 3	Homo sapiens	115-120
31258769-5	2019	WNT6 expression was detected using immunohistochemistry (IHC) analyses on paraffin-embedded specimens.	Paraffin	74-82	Wnt family member 6	Homo sapiens	0-4
31139323-9	2019	We evaluated TOX protein expression in paraffin-embedded skin biopsies with immunohistochemistry, showing nuclear staining of CTCL infiltrates, suggesting it is a candidate diagnostic biomarker.	Paraffin	39-47	thymocyte selection associated high mobility group box	Homo sapiens	13-16
30781400-3	2019	In this context, we evaluated the infiltration of FoxP3+ Tregs on 205 human formalin-fixed paraffin-embedded HNSCC and we assessed its prognostic value compared to other potential prognostic factors, including HPV infection.	Paraffin	91-99	forkhead box P3	Homo sapiens	50-55
32184668-5	2020	Methods: We assessed the expression of LETM1 and genes related to cancer stemness, epithelial-mesenchymal transition (EMT), cell cycle, and PI3K/Akt signaling in 133 paraffin-embedded PCa tissue samples and cancer cells by using immunohistochemistry, immunofluorescence, and Western blotting.	Paraffin	166-174	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	39-44
31745876-0	2020	Concurrent Immunohistochemical Localization and Western Blot Analysis of the MIF Receptor, CD74, in Formalin-Fixed, Paraffin-Embedded Tissue.	Paraffin	116-124	macrophage migration inhibitory factor	Homo sapiens	77-80
30268943-0	2019	A Single-Tube, EuroClonality-Inspired, TRG Clonality Multiplex PCR Aids Management of Patients with Enteropathic Diseases, including from Formaldehyde-Fixed, Paraffin-Embedded Tissues.	Paraffin	158-166	T cell receptor gamma locus	Homo sapiens	39-42
30414134-4	2019	Here we describe the detection of phospho-Smad1/5/9 on paraformaldehyde-fixed and paraffin-embedded tissue sections by immunofluorescence.	Paraffin	82-90	SMAD family member 1	Homo sapiens	42-47
30988760-4	2019	Immunohistochemical staining was used to detect the expression of EIF5A2 protein levels in 72 paraffin-embedded PCa tumor specimens.	Paraffin	94-102	eukaryotic translation initiation factor 5A2	Homo sapiens	66-72
30739992-5	2019	Expression levels of Twist1, a transcriptional regulator of epithelial-mesenchymal transition, were examined in paraffin-embedded tissue sections of an experimental rat breast model to find physiological alternations coincident with reproductive hormonal changes.	Paraffin	112-120	twist family bHLH transcription factor 1	Rattus norvegicus	21-27
31745876-0	2020	Concurrent Immunohistochemical Localization and Western Blot Analysis of the MIF Receptor, CD74, in Formalin-Fixed, Paraffin-Embedded Tissue.	Paraffin	116-124	CD74 molecule	Homo sapiens	91-95
31882696-6	2019	The nonsynonymous mutation for KMT2B p.Ile2602Val identified in the formalin-fixed paraffin-embedded tumor sample was also confirmed in the CSC.	Paraffin	83-91	lysine methyltransferase 2B	Homo sapiens	31-36
32146795-3	2019	Fascin marker staining was performed on paraffin blocks of breast samples using immunohistochemistry (IHC) method.	Paraffin	40-48	fascin actin-bundling protein 1	Homo sapiens	0-6
29189264-10	2018	CONCLUSIONS: Our study is the first to show CD123 is positive in a subset of formalin-fixed, paraffin-embedded MGZLs and CHLs, in contrast to PMBL which is largely negative.	Paraffin	93-101	interleukin 3 receptor subunit alpha	Homo sapiens	44-49
31278883-4	2019	Immunohistochemical studies in a cohort of 152 paraffin-embedded BC tissues displayed that upregulated expression of KIFC1 clearly correlated with pT status (P = .014) and recurrent status (P = .002).	Paraffin	47-55	kinesin family member C1	Homo sapiens	117-122
30062819-5	2018	TREX1 distribution in human brain was further evaluated by immunohistochemical analyses of formalin-fixed, paraffin-embedded samples from normal controls and patients with RVCL and ischemic stroke.	Paraffin	107-115	three prime repair exonuclease 1	Homo sapiens	0-5
30403872-1	2018	The discovery of appropriate synthetic reaction conditions for fabricating a stable zirconium-based molecular sieve (Zr-fum-fcu-MOF) with minimal defects and its utilization in the challenging separation of linear paraffins from branched paraffins is reported.	Paraffin	214-223	lysine acetyltransferase 8	Homo sapiens	128-131
30403872-1	2018	The discovery of appropriate synthetic reaction conditions for fabricating a stable zirconium-based molecular sieve (Zr-fum-fcu-MOF) with minimal defects and its utilization in the challenging separation of linear paraffins from branched paraffins is reported.	Paraffin	238-247	lysine acetyltransferase 8	Homo sapiens	128-131
31197258-3	2019	Here, the EuroClonality-NGS Working Group presents a multicentre technical feasibility study of a novel approach involving next-generation sequencing (NGS) of IGH and IGK loci rearrangements that is highly suitable for detecting IG gene rearrangements in frozen and formalin-fixed paraffin-embedded tissue specimens.	Paraffin	281-289	immunoglobulin heavy locus	Homo sapiens	159-162
30010043-7	2018	RESULTS: After detection of the CUX1-ALK fusion gene, RNA sequencing analysis of formalin-fixed paraffin-embedded sections from the primary tumor specimen was applied to reveal a 97-nucleotide fragment from CUX1 intron 8 inserted before the nucleotide 53 position in ALK exon 20.	Paraffin	96-104	cut like homeobox 1	Homo sapiens	207-211
31332036-3	2019	In our study, TP73 protein expression was detected by immunochemistry in 118 paraffin-embedded cervical cancer tissue specimens and 40 paraffin-embedded normal cervical epithelium tissue specimens.	Paraffin	77-85	tumor protein p73	Homo sapiens	14-18
30160021-0	2018	Stability of oestrogen and progesterone receptor antigenicity in formalin-fixed paraffin-embedded breast cancer tissue over time.	Paraffin	80-88	progesterone receptor	Homo sapiens	27-48
30410061-3	2018	METHODS: We developed a proximity ligation assay to detect ER and PR-B (ER:PR-B) interactions in formalin-fixed paraffin-embedded tissues.	Paraffin	112-120	RB transcriptional corepressor 1	Homo sapiens	66-70
30410061-3	2018	METHODS: We developed a proximity ligation assay to detect ER and PR-B (ER:PR-B) interactions in formalin-fixed paraffin-embedded tissues.	Paraffin	112-120	RB transcriptional corepressor 1	Homo sapiens	75-79
30115536-3	2018	In this research, we measured the expression of UQCRC2 protein by immunohistochemistry assay in 89 paired paraffin-embedded tumor tissues and corresponding adjacent normal tissues from patients with colorectal adenocarcinoma and investigated possible correlations of UQCRC2 expression with clinicopathological parameters and prognosis.	Paraffin	106-114	ubiquinol-cytochrome c reductase core protein 2	Homo sapiens	48-54
29725460-4	2018	In the present study, the expression of TFAP4 was detected in 30 matched pairs of fresh CRC tissues, 187 cases of clinical paraffin-embedded CRC tissues and CRC cell lines using the reverse transcriptase-quantitative polymerase chain reaction, immunohistochemistry or western blot analysis.	Paraffin	123-131	transcription factor AP-4	Homo sapiens	40-45
31332036-3	2019	In our study, TP73 protein expression was detected by immunochemistry in 118 paraffin-embedded cervical cancer tissue specimens and 40 paraffin-embedded normal cervical epithelium tissue specimens.	Paraffin	135-143	tumor protein p73	Homo sapiens	14-18
30448772-4	2019	NKp46 was next assessed by immunohistochemistry in paraffin-embedded biopsies from 204 patients with CD, RCDI, RCDII or GI T-cell lymphomas and from a validation cohort of 61 patients.	Paraffin	51-59	natural cytotoxicity triggering receptor 1	Homo sapiens	0-5
29343200-2	2018	This study examined CD31 immunoreactivity of 347 formalin-fixed, paraffin-embedded normal, nonneoplastic, and neoplastic canine tissues.	Paraffin	65-73	platelet and endothelial cell adhesion molecule 1	Homo sapiens	20-24
30294590-14	2018	We detected the MYD88 p.L265P mutation in formalin fixed paraffin embedded (FFPE) tissue from the brain biopsy and the CSF-ctDNA.	Paraffin	57-65	MYD88 innate immune signal transduction adaptor	Homo sapiens	16-21
30448772-7	2019	In paraffin biopsies, detection of &gt;25 NKp46+ IEL per 100 epithelial cells discriminated RCDII from CD and RCDI.	Paraffin	3-11	natural cytotoxicity triggering receptor 1	Homo sapiens	42-47
30015848-4	2018	In the present study, we evaluated the expression of AHR/HSP-90 in 25 formalin-fixed, paraffin-embedded human oral cancer specimens by IHC analysis.	Paraffin	86-94	aryl hydrocarbon receptor	Homo sapiens	53-56
31101574-3	2019	Herein, we assessed the expression of LETM1 and its relationship with cancer stemness genes, cell cycle markers, PI3K/Akt/NFkappaB signaling pathway genes, and HIF1alpha in 102 paraffin-embedded CRA tissue samples using immunohistochemistry (IHC).	Paraffin	177-185	leucine zipper and EF-hand containing transmembrane protein 1	Homo sapiens	38-43
30015909-4	2018	The present study also reported high expression of HES6 in 138/213 (64.8%) paraffin-embedded archived CRC specimens.	Paraffin	75-83	hes family bHLH transcription factor 6	Homo sapiens	51-55
29900041-3	2018	In this study, positive correlations between NTS and interleukin (IL)-8 were identified at both the mRNA and protein levels in 71 fresh HCC tissues and 100 paraffin-embedded HCC tissues.	Paraffin	156-164	chemokine (C-X-C motif) ligand 15	Mus musculus	53-71
29435030-5	2018	FAK expression was investigated in 100 formalin-fixed, paraffin-embedded human thymic epithelial tumor (TET) specimens using immunohistochemical analysis with FAK-specific monoclonal antibody 4.47, and the associations between FAK expression and clinicopathological parameters (including sex, age, tumor size, myasthenia gravis, World Health Organization classification and Masaoka-Koga stage) were analyzed.	Paraffin	55-63	protein tyrosine kinase 2	Homo sapiens	0-3
30251729-2	2018	OBJECTIVES: To compare immunohistochemical detection of Human chorionic gonadotropin (hCG) expression in paraffin embedded tissue of squamous cell carcinomas (SCC) and high grade squamous intraepithelial lesions (HSIL).	Paraffin	105-113	hypertrichosis 2 (generalised, congenital)	Homo sapiens	86-89
29032825-5	2017	We used PCR and capillary sequencing to assess the presence of specific TTC28-L1 transductions in formalin-fixed paraffin-embedded (FFPE) blocks from six different anatomical sites (five tumors and one normal control) for four ENOC and three CCOC cases, and compared the results to the presence of single nucleotide variations (SNVs)/frame shift (fs) mutations detected using multiplex PCR and next generation sequencing.	Paraffin	113-121	tetratricopeptide repeat domain 28	Homo sapiens	72-77
31105829-7	2019	Additionally, in 42 cases of renal cancer formalin-fixed paraffin-embedded specimens, patients with higher expression levels of miR-378a-5p had significantly longer overall survival rates (P&lt;0.05) than patients with lower miR-378a-5p expression levels.	Paraffin	57-65	MLX interacting protein	Homo sapiens	128-131
29218243-5	2017	Immunohistochemistry (IHC) was conducted to characterize the expression pattern of HBXIP in 152 archived paraffin-embedded ESCC and matched nontumorous tissues.	Paraffin	105-113	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	83-88
30630006-5	2019	Immunohistochemical analysis of 134 paraffin-embedded archived HCC tissues showed that the protein expression level of PES1 was positively correlated with clinical characteristics and reduced the survival time of HCC patients.	Paraffin	36-44	pescadillo ribosomal biogenesis factor 1	Homo sapiens	119-123
29089751-9	2017	The expression levels of TGF-beta/Smad pathway-related makers (TGF-betaRII, p-Smad2, p-Smad3, Smad7 and TGF-beta) in alveolar M2 macrophages were detected by two consecutive paraffin section IHS.	Paraffin	174-182	transforming growth factor, beta 1	Mus musculus	25-33
29089751-9	2017	The expression levels of TGF-beta/Smad pathway-related makers (TGF-betaRII, p-Smad2, p-Smad3, Smad7 and TGF-beta) in alveolar M2 macrophages were detected by two consecutive paraffin section IHS.	Paraffin	174-182	SMAD family member 7	Mus musculus	34-38
30175411-2	2018	We evaluated the expression level of miR-1247-5p in 224 formalin-fixed, paraffin-embedded specimens (112 BC and matched cancer free tissues) by quantitative real-time reverse transcriptase polymerase chain reaction (qRT-PCR).	Paraffin	72-80	microRNA 1247	Homo sapiens	37-45
30502715-3	2019	In our study, we validated the FOXP3/CD25 double staining antibody cocktails for detecting Tregs in paraffin-embedded tissue.	Paraffin	100-108	forkhead box P3	Homo sapiens	31-36
30032824-5	2018	MATERIALS AND METHODS: We developed a Droplet Digital PCR (ddPCR) assay to measure HOXA9 promoter methylation in formalin-fixed paraffin-embedded (FFPE) biospecimens generated during routine pathology.	Paraffin	128-136	homeobox A9	Homo sapiens	83-88
29564261-2	2017	Materials and Methods: Immunohistochemistry (IHC) study for HDGF was performed on paraffin-embedded blocks of patients with breast carcinoma in Modarres hospital, Tehran, Iran, since 1387-1390 (74 cases); three separate pathologists read the slides after complete IHC staining.	Paraffin	82-90	heparin binding growth factor	Homo sapiens	60-64
30502715-9	2019	In conclusion, FOXP3/CD25 double staining antibody cocktails can be easily applied to paraffin-embedded tissue, and FOXP3+/CD25+ Tregs count was positively correlated with FOPX3+ Tregs count but they were not interchangeable.	Paraffin	86-94	forkhead box P3	Homo sapiens	15-20
30391262-12	2019	CONCLUSIONS: Routine combination of choline acetyltransferase and myelin basic protein immunostaining provides a highly specific, highly contrasted paraffin-embedded sections where optical differentiation of myelinated motor fibers is easy and straightforward.	Paraffin	148-156	myelin basic protein	Homo sapiens	66-86
27028240-3	2017	To address this, we have developed a 2-step diagnostic test to identify NTRK1, NTRK2, NTRK3, ROS1, and ALK rearrangements in formalin-fixed paraffin-embedded clinical specimens.	Paraffin	140-148	neurotrophic receptor tyrosine kinase 1	Homo sapiens	72-77
29891190-3	2018	HOMER2 protein expression was detected on paraffin-embedded tissues from 336 cases using immunohistochemistry (IHC).	Paraffin	42-50	homer scaffold protein 2	Homo sapiens	0-6
29894486-9	2018	Immunohistochemistry revealed the level of FOXP3 expression to be lower in tumoral MFs than in plaque lesions in paraffin-embedded tissue.	Paraffin	113-121	forkhead box P3	Homo sapiens	43-48
30655829-5	2019	The protein expression level of AKR1B10 was determined in paraffin-embedded biopsy specimens using immunohistochemistry.	Paraffin	58-66	aldo-keto reductase family 1 member B10	Homo sapiens	32-39
29169286-5	2018	Reverse transcription-polymerase chain reaction analysis using a formalin-fixed, paraffin-embedded tumor tissue specimen revealed the CRTC1-MAML2 fusion gene transcript.	Paraffin	81-89	CREB regulated transcription coactivator 1	Homo sapiens	134-139
28658321-2	2017	METHOD OF STUDY: Stathmin-1 (STMN1), p53, and tristetraprolin (TTP) expression in paraffin-embedded villus tissue was determined using immunohistochemistry.	Paraffin	82-90	ZFP36 ring finger protein	Homo sapiens	63-66
29707109-4	2018	Methods: PDCD4 nuclear expression was assessed by immunohistochemistry (IHC) in 40 non-neoplastic pleural (NNP) and 40 MPM formalin-fixed and paraffin-embedded specimens.	Paraffin	142-150	programmed cell death 4	Homo sapiens	9-14
28735527-5	2017	We evaluated the expression of FAP-alpha by PCR techniques in fresh frozen and in paraffin-embedded tissues, and compared it to the expression in non-cancer tissues.	Paraffin	82-90	fibroblast activation protein alpha	Homo sapiens	31-40
30322013-6	2018	Quantitative real-time RT-PCR of RNA extracted from formalin-fixed paraffin-embedded (FFPE) samples showed that the relative expression of miR-143 was higher in GBM patients compared to control individuals.	Paraffin	67-75	microRNA 143	Homo sapiens	139-146
28735527-6	2017	To detect the protein expression level of FAP-alpha in paraffin-embedded tissues we used chromogenic immunohistochemical (IHC) staining.	Paraffin	55-63	fibroblast activation protein alpha	Homo sapiens	42-51
28323289-2	2017	METHODS: We used modified BIOMED-2 protocols to detect monoclonal expansions of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) genes in 957 formalin-fixed paraffin-embedded samples from 717 patients.	Paraffin	167-175	immunoglobulin heavy constant delta	Homo sapiens	80-106
29363723-8	2018	These antibodies against recombinant proteins may be used effectively to detect BDV p24 and p40 in paraffin sections.	Paraffin	99-107	interleukin 9	Homo sapiens	92-95
27389555-1	2018	BACKGROUND: Growth factor receptor HER3 (ErbB3) lacks standardized immunohistochemistry (IHC)-based methods for formalin-fixed paraffin-embedded (FFPE) tissue samples.	Paraffin	127-135	erb-b2 receptor tyrosine kinase 3	Homo sapiens	35-39
27389555-1	2018	BACKGROUND: Growth factor receptor HER3 (ErbB3) lacks standardized immunohistochemistry (IHC)-based methods for formalin-fixed paraffin-embedded (FFPE) tissue samples.	Paraffin	127-135	erb-b2 receptor tyrosine kinase 3	Homo sapiens	41-46
28323289-2	2017	METHODS: We used modified BIOMED-2 protocols to detect monoclonal expansions of immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) genes in 957 formalin-fixed paraffin-embedded samples from 717 patients.	Paraffin	167-175	immunoglobulin heavy constant delta	Homo sapiens	108-111
29802359-0	2018	Duplications of KIAA1549 and BRAF screening by Droplet Digital PCR from formalin-fixed paraffin-embedded DNA is an accurate alternative for KIAA1549-BRAF fusion detection in pilocytic astrocytomas.	Paraffin	87-95	KIAA1549	Homo sapiens	16-24
28675018-5	2017	Double immunohistochemical analysis was applied to investigate the expression of CD44 and CD133 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues.	Paraffin	99-107	prominin 1	Homo sapiens	90-95
29475926-4	2018	CUL-1 and -2 protein expression was examined with IHC on paraffin-embedded tissue sections.	Paraffin	57-65	cullin 1	Homo sapiens	0-12
30377136-4	2018	We also examined MMP20 protein expressions in 134 paraffin-embedded endometrial carcinoma tissues and 34 paraffin-embedded endometrial tissues using immunohistochemistry.	Paraffin	50-58	matrix metallopeptidase 20	Homo sapiens	17-22
28343305-7	2017	The presence of MECT1-MAML2 was evaluated with reverse transcription polymerase chain reaction using RNA extracted from formalin-fixed paraffin-embedded tumor tissue.	Paraffin	135-143	CREB regulated transcription coactivator 1	Homo sapiens	16-21
30058680-2	2018	PATIENTS AND METHODS: The expression level of miR-551b was determined in 50 paraffin-embedded cervical specimens (10 normal squamous epithelium, 18 condylomas, 8 CIN1, and 14 CIN2-3) using quantitative Real-time polymerase chain reaction (qRT-PCR).	Paraffin	76-84	microRNA 551b	Homo sapiens	46-54
28410240-8	2017	Immunohistochemistry (IHC) staining assay of 145 paraffin-embedded gastric cancer tissues showed that Ulk1 was over-expressed in majority (114 out of 145) of gastric cancer tissues.	Paraffin	49-57	unc-51 like autophagy activating kinase 1	Homo sapiens	102-106
28128276-5	2017	We performed whole gene expression analysis of formalin-fixed paraffin-embedded tissue from sarcomatoid mesothelioma and lung sarcomatoid carcinoma and observed significant differences in the expression of MUC4 and other genes between sarcomatoid mesothelioma and lung sarcomatoid carcinoma.	Paraffin	62-70	mucin 4, cell surface associated	Homo sapiens	206-210
29970672-3	2018	The expression of CD133 protein in paraffin specimens of two groups of patients was detected with immunohistochemistry SP assay.	Paraffin	35-43	prominin 1	Homo sapiens	18-23
28356761-6	2017	The protein expression of EphB4 and EphrinB2 was examined by immunohistochemistry using paraffin-embedded tumor tissues.	Paraffin	88-96	EPH receptor B4	Homo sapiens	26-31
29116339-4	2018	In this study, we identified for the first time that beta-arrestin-1 was upregulated in the kidney from mice with unilateral ureteral obstruction nephropathy as well as in the paraffin-embedded sections of human kidneys from the patients with diabetic nephropathy, polycystic kidney, or uronephrosis, which normally causes renal fibrosis.	Paraffin	176-184	arrestin, beta 1	Mus musculus	53-68
30431717-4	2018	The expression of NEDD9 was analyzed immunohistochemically in 71 formalin-fixed and paraffin-embedded transbronchial biopsy specimens of primary lung adenocarcinoma.	Paraffin	84-92	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	18-23
30056896-6	2018	Microscopic evaluation of ETAR expression (polyclonal antibody) was performed on paraffin sections.	Paraffin	81-89	endothelin receptor type A	Homo sapiens	26-30
28255115-3	2017	The protein expressions of CXCL12, CXCR4 and CXCR7 in paraffin-embedded samples from 160 patients with different molecular subtypes were detected by immunohistochemical staining.	Paraffin	54-62	C-X-C motif chemokine ligand 12	Homo sapiens	27-33
28079349-4	2018	METHODS: mRNA expression of IL13Ralpha2 was measured using real-time quantitative reverse transcription polymerase chain reaction (qRT-PCR) in 52 formalin-fixed paraffin-embedded glioma samples (4 pilocytic astrocytomas, 9 diffuse astrocytomas, 12 anaplastic astrocytomas, and 27 glioblastomas, grade IV).	Paraffin	161-169	interleukin 13 receptor subunit alpha 2	Homo sapiens	28-39
28280347-4	2017	METHODS: The expression of ALDOA was detected using immunohistochemical staining in 162 formalin-fixed, paraffin-embedded ccRCC sections.	Paraffin	104-112	aldolase, fructose-bisphosphate A	Homo sapiens	27-32
28579665-1	2017	Immunohistochemical detection of FOXP3 antigen is a usable marker for detection of regulatory T lymphocytes (TR) in formalin fixed and paraffin embedded sections of different types of tumor tissue.	Paraffin	135-143	forkhead box P3	Homo sapiens	33-38
29122010-5	2017	Nav1.5 and ER-beta expression was detected by using immunohistochemistry (IHC) on tissue microarray constructed from paraffin-embedded specimens.	Paraffin	117-125	estrogen receptor 2	Homo sapiens	11-18
29720147-5	2018	Quantitative real-time polymerase chain reaction (qRT-PCR), western blotting (WB) and immunohistochemical (IHC) assays were performed to investigate CRBP-1 expression in 101 paraffin-embeded TSCC tissues and 48 pairs of freshly frozen tissues.	Paraffin	174-182	retinol binding protein 1	Homo sapiens	149-155
28583379-4	2017	METHODS: The presence of the FGFR4-388Arg variant was determined in 114 formalin-fixed, paraffin-embedded lung SCC tissue samples by DNA genotyping and was correlated with clinicopathologic data.	Paraffin	88-96	fibroblast growth factor receptor 4	Homo sapiens	29-34
28093193-7	2017	RESULTS: HBXIP protein showed a mainly cytoplasmic staining pattern in cervical cancers by using IHC staining in paraffin embedded cervical cancer tissues and IF staining in SiHa cervical cancer cells.	Paraffin	113-121	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	9-14
29510198-3	2018	In the present study, we checked the expression of miR-485-5p in 87 pairs of paraffin-embedded lung cancer and matched non-cancerous specimens.	Paraffin	77-85	microRNA 485	Homo sapiens	51-58
28814085-3	2017	METHODS: The immunostaining status of ADAMTS1,8, and 18 were investigated in formalin-fixed paraffin-embedded samples of 25 patients who underwent curative resection for GC.	Paraffin	92-100	ADAM metallopeptidase with thrombospondin type 1 motif 1	Homo sapiens	38-45
29054399-8	2017	This assay also proved to be highly efficient in detecting the MYD88 L265P mutation, even in archival paraffin-embedded tissues.	Paraffin	102-110	MYD88 innate immune signal transduction adaptor	Homo sapiens	63-68
29617441-4	2018	Expressions of PD-1 and PD-L1 were detected immunohistochemically in 25 formalin-fixed, paraffin-embedded tumor specimens from 24 patients with intracranial germinoma consisting of 22 primary and 3 recurrent tumors.	Paraffin	88-96	programmed cell death 1	Homo sapiens	15-19
28848996-3	2017	In the present study, ROCK1 expression was examined in 356 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissues using immunohistochemistry, and its clinical implications and prognostic significance were analyzed.	Paraffin	75-83	Rho associated coiled-coil containing protein kinase 1	Homo sapiens	22-27
28472789-3	2017	METHODS: Immuno-histochemistry was carried out to characterize the ZNF667 expression in paraffin-embedded HCC samples.	Paraffin	88-96	zinc finger protein 667	Homo sapiens	67-73
29707138-4	2018	RNF2 was detected immunohistochemically in standard formalin-fixed paraffin-embedded samples of 9 benign nevi, 60 melanomas and 24 nodal metastases.	Paraffin	67-75	ring finger protein 2	Homo sapiens	0-4
27629878-5	2017	Immunohistochemistry was used to detect Dsg2 expression in 70 cases of paraffin-embedded NSCLC tissues.	Paraffin	71-79	desmoglein 2	Homo sapiens	40-44
28107608-9	2017	RESULTS: We observed that TCF3 had a higher expression in NPC than in non-tumourous nasopharyngeal tissues of 117 archived paraffin-embedded NPC specimens, and 80 (68.4%) biopsy tissues revealed high levels of TCF3 expression.	Paraffin	123-131	transcription factor 3	Homo sapiens	26-30
30697297-6	2018	Methods: The current studyexplored FOXE-1 and STIP-1 expressions by the immunohistochemical methods in 36 paraffin blocks retrieved from 36 patients of PTC, analyzed the relationships between their levels of expression,clinicopathological parameters, prognosis, and survival of patients.	Paraffin	106-114	forkhead box E1	Homo sapiens	35-41
28718367-10	2017	HBXIP protein showed a mainly cytoplasmic staining pattern in non-small-cell lung cancer using immunohistochemical staining in paraffin-embedded non-small-cell lung cancer tissues and immunofluorescence staining in A549 cells.	Paraffin	127-135	late endosomal/lysosomal adaptor, MAPK and MTOR activator 5	Homo sapiens	0-5
29629425-4	2017	The first approach involved identification of patient-specific genomic EWSR1 fusion breakpoints in formalin-fixed, paraffin-embedded tumor DNA using a broad, hybridization capture-based next generation sequencing (NGS) panel, followed by design of patient-specific droplet digital PCR (ddPCR) assays for plasma cfDNA interrogation .	Paraffin	115-123	EWS RNA binding protein 1	Homo sapiens	71-76
28485172-3	2017	FXR protein expression was assessed immunohistochemically on paraffin-embedded breast cancer tissues obtained from 115 breast cancer patients and was statistically analyzed with clinicopathological parameters, estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) expression, as well as with tumor cells" proliferative capacity and overall and disease-free patients" survival.	Paraffin	61-69	nuclear receptor subfamily 1 group H member 4	Homo sapiens	0-3
29642180-3	2018	The protein expression of CSTA was evaluated by the immunostaining of formalin-fixed, paraffin-embedded sections of ESCC samples from 59 patients who underwent surgery, and its relationship with clinical features was analyzed.The mRNA expression of CSTA was significantly decreased in ESCC compared with that in matched normal mucosa (P &lt; .0001).	Paraffin	86-94	cystatin A	Homo sapiens	26-30
27876449-12	2017	The values of temperature showed significant increment immediately after paraffin therapy at each time point in Exp group.	Paraffin	73-81	muscleblind like splicing regulator 1	Homo sapiens	112-115
29079956-6	2018	Eighty-six of 126 (68.3%) paraffin-embedded glioma biopsies showed high expression of COX7A2.	Paraffin	26-34	cytochrome c oxidase subunit 7A2	Homo sapiens	86-92
27978870-3	2016	METHODS: The expressions of PD-1 and PD-L1 in 20 cases of PC paraffin-embedded tissue specimens were detected through immunohistochemistry.	Paraffin	61-69	programmed cell death 1	Homo sapiens	28-32
28411179-5	2017	Immunohistochemistry with anti-CLU was performed on paraffin sections from 39 thyroid tumors.	Paraffin	52-60	clusterin	Homo sapiens	31-34
30056913-4	2018	Immunohistochemical evaluation of AT1R expression was performed on 4 mum-thick paraffin sections mounted on silanized slides.	Paraffin	79-87	angiotensin II receptor type 1	Homo sapiens	34-38
26657878-10	2017	These results suggest that these antibodies are reliable and reproducible tools for immunohistochemistry analysis of ER and PR expression levels in formalin-fixed and paraffin-embedded breast carcinoma tissues on the Dako Omnis platform.	Paraffin	167-175	progesterone receptor	Homo sapiens	124-126
28247010-6	2017	Real-time PCR analysis conducted using formalin-fixed paraffin-embedded tissues with atherosclerotic lesions demonstrated an increase in the levels of many inflammatory chemokines, including Cxcl16, while antibody arrays performed using frozen atherosclerotic tissue samples showed elevated TIMP-1 expression.	Paraffin	54-62	chemokine (C-X-C motif) ligand 16	Mus musculus	191-197
28259923-5	2017	We found that PLAGL2 expression was upregulated in the paraffin-embedded CRC tissues compared to borderline or benign tissues.	Paraffin	55-63	PLAG1 like zinc finger 2	Homo sapiens	14-20
28101486-4	2016	METHODS: ER-alpha and PR expression was evaluated in paraffin-embedded tumor tissue samples of 45 males and 158 females followed up for 7.2 +- 3.7 years.	Paraffin	53-61	progesterone receptor	Homo sapiens	22-24
27430713-4	2016	KLK5 expression was detected in 48 paraffin-embedded tumor tissue samples and corresponding tumor-free areas within the same specimens, 40 paired normal and CRC frozen tissues, and serum samples from 70 patients with CRC (including 38 serum samples taken pre- and post-surgery) and 53 healthy individuals.	Paraffin	35-43	kallikrein related peptidase 5	Homo sapiens	0-4
28928843-8	2017	Immunohistochemical analysis revealed decreased expression of SPOPL in 42/56 (75%) paraffin-embedded archival MB biopsies, and SPOPL expression may be associated with the MB differentiation level (P=0.011).	Paraffin	83-91	speckle type BTB/POZ protein like	Homo sapiens	62-67
27431784-5	2016	The expression levels of miR-203a were analyzed in 109 formalin-fixed paraffin-embedded paired normal and tumor tissue samples.	Paraffin	70-78	microRNA 203a	Homo sapiens	25-33
28415912-1	2017	A novel immunohistochemistry (IHC) approach has been developed to label and localize osterix, a bone-specific transcription factor, within formalin-fixed, paraffin-embedded, tissue-engineered constructs uniquely containing synthetic polymers and human periosteal tissue.	Paraffin	155-163	Sp7 transcription factor	Homo sapiens	85-92
27457382-3	2016	METHODS: Foxp3 expression was examined using immunohistochemistry (IHC) in paraffin-embedded tissue samples from 273 OSCC patients.	Paraffin	75-83	forkhead box P3	Homo sapiens	9-14
28191697-9	2017	Monoclonal rearrangement of the T-cell receptor (TCR) and immunoglobulin heavy chain (IGH) genes was confirmed by polymerase chain reaction (PCR) using whole paraffin sections.	Paraffin	158-166	immunoglobulin heavy constant delta	Homo sapiens	58-84
28191697-9	2017	Monoclonal rearrangement of the T-cell receptor (TCR) and immunoglobulin heavy chain (IGH) genes was confirmed by polymerase chain reaction (PCR) using whole paraffin sections.	Paraffin	158-166	immunoglobulin heavy constant delta	Homo sapiens	86-89
28606091-3	2017	METHODS: The relationship between LASP2 expression and clinical characteristics of CRC was analyzed in 89 paraffin-embedded archived CRC specimens by immunohistochemistry (IHC).	Paraffin	106-114	nebulette	Homo sapiens	34-39
28095858-4	2017	METHODS: qPCR and in situ hybridization were used to evaluate the expression of miR-4775 in 544 pairs of paraffin-embedded normal and CRC tissues.	Paraffin	105-113	microRNA 4775	Homo sapiens	80-88
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Paraffin	140-148	septin 9	Homo sapiens	35-40
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Paraffin	140-148	DNA fragmentation factor subunit alpha	Homo sapiens	81-85
26892748-5	2016	The results of TGA showed that sublimit temperature values regarding the first degradation steps of both capsules were quite over the phase change or working temperatures of encapsulated paraffins.	Paraffin	187-196	T-box transcription factor 1	Homo sapiens	15-18
28137569-7	2017	As a case study, we will describe a breast cancer-focused super-SILAC approach, which we used in a recent publication to profile hPTMs in frozen and formalin-fixed paraffin-embedded human samples, revealing previously unknown marks that differentiate breast cancer subtypes.	Paraffin	164-172	parathymosin	Homo sapiens	129-134
28549422-4	2017	METHODS: Immunohistochemical staining of pVHL in formalin-fixed, paraffin-embedded sections of cancerous and other tissues from 19 tongue cancer patients showed positivity for LOH of VHL in four samples, negativity in four samples, and was non-informative in 11 samples.	Paraffin	65-73	von Hippel-Lindau tumor suppressor	Homo sapiens	41-45
27654256-2	2016	METHODS: Immunohistochemistry was performed to detect the expression of CK19 and SCCAg using polyclonal antibody on 149 pair of formalin-fixed, paraffin-embedded cervical squamous cell carcinoma and histologically negative sentinel lymph node tissue samples, and results were compared with data from the prospectively registry of cervical squamous cell carcinoma by univariate and multivariate logistic regression model focusing specifically on recurrence.	Paraffin	144-152	keratin 19	Homo sapiens	72-76
26662803-0	2016	Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.	Paraffin	83-91	hes family bHLH transcription factor 1	Homo sapiens	31-35
26200836-2	2016	MATERIALS AND METHODS: EnVision immunohistochemical method for determining the expression of BRMS1 and HPA was used in routinely paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma, peritumoral tissues, polyp, and chronic cholecystitis.	Paraffin	129-137	BRMS1 transcriptional repressor and anoikis regulator	Homo sapiens	93-98
28549422-4	2017	METHODS: Immunohistochemical staining of pVHL in formalin-fixed, paraffin-embedded sections of cancerous and other tissues from 19 tongue cancer patients showed positivity for LOH of VHL in four samples, negativity in four samples, and was non-informative in 11 samples.	Paraffin	65-73	von Hippel-Lindau tumor suppressor	Homo sapiens	42-45
28336434-5	2017	Immunohistochemistry (IHC) was carried out to detect Vav1 expression in paraffin samples from 112 primary ESCC patients.	Paraffin	72-80	vav guanine nucleotide exchange factor 1	Homo sapiens	53-57
26453693-5	2016	EXPERIMENTAL DESIGN: Immunohistochemistry for tumor expression of CXCL12 was assessed as a biomarker of relapse alongside vascular invasion, histology (percentage embryonal carcinoma), and MIB1 staining for proliferation in formalin-fixed paraffin-embedded orchidectomy samples from patients enrolled in the Medical Research Council"s TE08/22 prospective trials of surveillance in stage I NSGCTs.	Paraffin	239-247	C-X-C motif chemokine ligand 12	Homo sapiens	66-72
27159521-9	2016	Immunohistochemical staining of paraffin-embedded skin sections showed enrichment of IFI-16 in CD31-positive vascular endothelial cells in biopsy specimens from scleroderma patients and normal controls.	Paraffin	32-40	platelet and endothelial cell adhesion molecule 1	Homo sapiens	95-99
28087477-3	2017	TNFAIP8 expression was evaluated using real-time polymerase chain reaction (PCR) and Western blot analysis in 20 fresh IDC tissues and immunohistochemical analysis in 351 paraffin-embedded IDC tissues.	Paraffin	171-179	TNF alpha induced protein 8	Homo sapiens	0-7
26872033-6	2016	In preceding immunohistochemistry experiments using paraffin-block sections from endometriosis (N = 33) and control (N = 27) group, retrospectively, HMGB-1 expression was shown in both epithelial and stromal cell.	Paraffin	52-60	high mobility group box 1	Homo sapiens	149-155
26285647-10	2016	Immunohistochemical (IHC) staining of PDCD4, one of the signature proteins, on an independent set of formalin-fixed paraffin-embedded tumor tissues provided and independent technical validation (HR = 0.72; 95% CI = 0.57 to 0.92; multivariate Cox regression p value = 0.009).	Paraffin	116-124	programmed cell death 4	Homo sapiens	38-43
28137646-5	2017	Moreover, whole mount preparations and paraffin sections both demonstrated that the number of CD68+ macrophages in the APP/PS1 mice ileum significantly increased (p<0.05).	Paraffin	39-47	CD68 antigen	Mus musculus	94-98
26450751-5	2016	SUBJECTS AND METHODS: Expression patterns of FGF19 protein in 100 paired formalin-fixed and paraffin-embedded cancerous and adjacent noncancerous tissues from patients with thyroid cancer were detected by immunohistochemistry.	Paraffin	92-100	fibroblast growth factor 19	Homo sapiens	45-50
29120119-2	2017	Immunohistochemistry was performed on formalin-fixed, paraffin-embeddedtissue by the RET, p27 and cyclin D1 antibodies.	Paraffin	54-62	cyclin D1	Homo sapiens	98-107
26709519-6	2015	Immunohistochemistry (IHC) was used to analyze B3GNT3 protein expression in paraffin-embedded tissues from 196 early-stage cervical cancer patients.	Paraffin	76-84	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 3	Homo sapiens	47-53
28096238-7	2017	Interestingly, immunofluorescence labeling performed on formalin-fixed paraffin-embedded prostate tissues showed an exclusive expression of the TRPA1 channel in prostate cancer stromal cells.	Paraffin	71-79	transient receptor potential cation channel subfamily A member 1	Homo sapiens	144-149
26545775-6	2015	Immunohistochemistry (IHC) was conducted to characterize the expression pattern of Thoc1 in 185 archived paraffin-embedded CRC specimens.	Paraffin	105-113	THO complex 1	Homo sapiens	83-88
27707590-7	2017	We established LINC00518 and PRAME in both adhesive patch melanoma samples and underlying formalin fixed paraffin embedded (FFPE) samples of surgically excised primary melanomas and in melanoma lymph node metastases.	Paraffin	105-113	PRAME nuclear receptor transcriptional regulator	Homo sapiens	29-34
26755907-5	2015	The expression of CXCR4 and CXCL12 was assessed by immunohistochemistry on the paraffin blocks and compared to the expression of angiogenesis marker (CD34) and proliferation indicators (Ki-67, AgNORs).	Paraffin	79-87	C-X-C motif chemokine ligand 12	Homo sapiens	28-34
27734382-6	2017	Here, we describe a method for visualizing the CCN2 signal as an odontogenic activity in formalin-fixed paraffin-embedded (FFPE) sections of demineralized human teeth and human dental pulp cells.	Paraffin	104-112	cellular communication network factor 2	Homo sapiens	47-51
25917404-7	2015	It is apparent from immonohistology data that both benign and cancerous (primary and metastasis) formalin fixed paraffin embedded (FFPE) tissue samples exhibit CLU expression.	Paraffin	112-120	clusterin	Homo sapiens	160-163
27734400-4	2017	This chapter describes a detailed in situ hybridization technique for the detection of CCN1 and CCN5 in formalin-fixed, paraffin-embedded patient samples of breast and pancreatic cancers.	Paraffin	120-128	cellular communication network factor 5	Homo sapiens	96-100
25896974-9	2015	We identified two new formalin-fixed, paraffin-embedded tissue-compatible diagnostic immunohistochemical markers; LMOD1 for subtype I leiomyosarcoma and ARL4C for subtype II leiomyosarcoma.	Paraffin	38-46	leiomodin 1	Homo sapiens	114-119
25896974-9	2015	We identified two new formalin-fixed, paraffin-embedded tissue-compatible diagnostic immunohistochemical markers; LMOD1 for subtype I leiomyosarcoma and ARL4C for subtype II leiomyosarcoma.	Paraffin	38-46	ADP ribosylation factor like GTPase 4C	Homo sapiens	153-158
27994670-4	2016	Then western blotting and immunohistochemistry were used to assess miR-320a target gene expression in fresh frozen (n=19, breast cancer and matched non-malignant adjacent tissue samples) and formalin-fixed paraffin-embedded (FFPE) (n=130, invasive BC tissues, the same panel detected for miR-320a expression previously) breast tissues, respectively.	Paraffin	206-214	microRNA 320a	Homo sapiens	67-75
26186215-3	2015	METHODS: A multiple immunofluorescence technique was employed to concomitantly and quantitatively visualize the nuclear localization of p65 and RelB in 200 paraffin embedded samples.	Paraffin	156-164	RELA proto-oncogene, NF-kB subunit	Homo sapiens	136-139
25132355-9	2015	Using paraffin sections from human cortex, cerebellum, and hippocampus, OATP1A2 was localized to neurons and neuronal processes, while OATP2B1 is expressed in endothelial cells of brain capillaries.	Paraffin	6-14	solute carrier organic anion transporter family member 1A2	Homo sapiens	72-79
27705080-7	2016	Moreover, the anti-Pax1 MAbs cross-react with human PAX1 protein and are applicable in immunohistochemical detection procedures using paraformaldehyde/formalin-fixed tissues embedded in paraffin.	Paraffin	186-194	paired box 1	Homo sapiens	19-23
26175849-3	2015	MATERIALS AND METHODS: In this paper, we explored the expression of miR-29b in a cohort of 67 pairs of formalin-fixed paraffin-embedded specimens with detailed pathological and clinical characteristics, and further analyzed the effects of miR-29b on the malignant phenotype of HER-2-positive breast cancer cells and the relevant mechanisms involved.	Paraffin	118-126	microRNA 29b-1	Homo sapiens	68-75
27705080-7	2016	Moreover, the anti-Pax1 MAbs cross-react with human PAX1 protein and are applicable in immunohistochemical detection procedures using paraformaldehyde/formalin-fixed tissues embedded in paraffin.	Paraffin	186-194	paired box 1	Homo sapiens	52-56
27287872-5	2016	Furthermore, in our large set of formalin-fixed paraffin-embedded cohort (n = 338), VCAN protein was detected exclusively in cancer stroma by immunohistochemistry, demonstrating a stepwise increase of stromal VCAN from normal tissues through stage 0 to stage IV tumors.	Paraffin	48-56	versican	Homo sapiens	84-88
26221920-4	2015	MATERIAL AND METHODS: Immunohistochemical detection of MUC-1 protein using HMFG-1 and HMFG-2 MoAbs was made in 5 mm thick, paraffin embedded slides, and the avidin-biotin method was used.	Paraffin	123-131	mucin 1, cell surface associated	Homo sapiens	55-60
27251576-3	2016	Here, our immunohistochemistry (IHC) assay and Western blot assay results showed that Nek1 expression was significantly upregulated in fresh and paraffin-embedded human glioma tissues.	Paraffin	145-153	NIMA related kinase 1	Homo sapiens	86-90
25876105-11	2015	CONCLUSION: Increased GLB1 is a valuable marker in formalin-fixed paraffin-embedded (FFPE) tissues for the senescence-like phenotype and associates with improved cancer outcomes.	Paraffin	66-74	galactosidase beta 1	Homo sapiens	22-26
25503078-3	2015	We evaluated the use of WRN protein immunohistochemistry for diagnosing WS using paraffin-embedded bone marrow sections.	Paraffin	81-89	WRN RecQ like helicase	Homo sapiens	24-27
25503078-8	2015	Thus, immunohistochemical detection of WRN in erythroblasts from bone marrow paraffin sections could be useful in screening of WS cases and worthy of further molecular confirmation.	Paraffin	77-85	WRN RecQ like helicase	Homo sapiens	39-42
27045402-1	2016	In the present study, our aim was to assess the incidence of BCL-1 gene rearrangements in formalin-fixed paraffin embedded (FFPE) tissue in patients with non-Hodgkin lymphomas (NHL).	Paraffin	105-113	cyclin D1	Homo sapiens	61-66
25973121-9	2015	Fluorescence in situ hybridization on paraffin section showed a translocation involving the EWSR1 gene region.	Paraffin	38-46	EWS RNA binding protein 1	Homo sapiens	92-97
26799253-4	2016	Immunohistochemistry was performed to examine EIF5A2 protein expression in paraffin-embedded tissues from 314 patients with cervical cancer.	Paraffin	75-83	eukaryotic translation initiation factor 5A2	Homo sapiens	46-52
25349132-7	2015	In paraffin embedded tissues, we found that tumor infiltrating lymphocytes expressed PD-1 in 3/6 cases.	Paraffin	3-11	programmed cell death 1	Homo sapiens	85-89
27255554-4	2016	METHODS: Immunohistochemistry of HK2 and Beta2AR was performed on 155 paraffin embedded HCC samples retrieved from the archives of pathology department.	Paraffin	70-78	hexokinase 2	Homo sapiens	33-36
25429837-6	2015	Immunohistochemistry analysis was performed on formalin-fixed paraffin-embedded section of 116 cases of EOCs and indicated that USP14 was significantly associated with clinical pathologic variables.	Paraffin	62-70	ubiquitin specific peptidase 14	Homo sapiens	128-133
26662140-2	2015	Here we use quantitative real-time polymerase chain reaction (qRT-PCR) to investigate the expression of the microRNAs resident on chromosome 21 (miR-ch21) in laser capture microdissected (LCM) tissues from formalin-fixed paraffin-embedded (FFPE) archived, prostate adenocarcinoma samples.	Paraffin	221-229	MLX interacting protein	Homo sapiens	145-148
27267836-4	2016	In this study, we determined the PHGDH protein expression using tissue microarray immunohistochemistry (TMA-IHC) on 193 pairs of formalin-fixed, paraffin-embedded specimens of CRC and adjacent tissues, 25 chronic colitis, 41 low-, and 19 high-grade intraepithelial neoplasia specimens, and we also determined PHGDH mRNA level using quantitative reverse transcription PCR (qRT-PCR) on additional 23 pairs of fresh CRC tissues and adjacent tissues.	Paraffin	145-153	phosphoglycerate dehydrogenase	Homo sapiens	33-38
25270739-4	2015	PTOV1 protein expression was also analyzed in archived paraffin-embedded EOC tissues using immunohistochemistry (IHC), and its association with overall survival of patients was analyzed by statistical analysis.	Paraffin	55-63	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	0-5
26500335-0	2016	Immunohistochemical detection of cytoplasmic nucleophosmin in formalin-fixed paraffin-embedded marrow trephine biopsies in acute myeloid leukaemia.	Paraffin	77-85	nucleophosmin 1	Homo sapiens	45-58
25432794-6	2014	For detection of the NAB2-STAT6 fusion gene, RT-PCR was performed using RNA extracted from formalin-fixed and paraffin-embedded tissues.	Paraffin	110-118	NGFI-A binding protein 2	Homo sapiens	21-25
26592251-5	2016	BHMT expression was analyzed in 68 paired HCC samples (HCC tissues vs matched adjacent non-cancerous liver tissues), 115 paraffin-embedded HCC sections (primary cohort), and 65 paraffin-embedded HCC sections (validation cohort) using immunohistochemistry (IHC).	Paraffin	121-129	betaine--homocysteine S-methyltransferase	Homo sapiens	0-4
25427922-5	2014	In addition, immunohistochemistry (IHC) was used to examine URG4 expression in paraffin-embedded tissues from 167 cervical cancer patients (FIGO stages Ib1-IIa2).	Paraffin	79-87	upregulator of cell proliferation	Homo sapiens	60-64
27430660-10	2016	Finally, SERPIND1 (HCII) was validated at the protein level by immunohistochemistry in 107 paraffin-embedded ovarian tissues.	Paraffin	91-99	serpin family D member 1	Homo sapiens	9-17
27430660-10	2016	Finally, SERPIND1 (HCII) was validated at the protein level by immunohistochemistry in 107 paraffin-embedded ovarian tissues.	Paraffin	91-99	serpin family D member 1	Homo sapiens	19-23
27618787-3	2016	The purpose of this study was to accurately quantify HER2-HER3 dimerisation in formalin fixed paraffin embedded (FFPE) breast cancer tissue as a novel prognostic biomarker.FFPE tissues were obtained from patients included in the METABRIC (Molecular Taxonomy of Breast Cancer International Consortium) study.	Paraffin	94-102	erb-b2 receptor tyrosine kinase 3	Homo sapiens	58-62
25373709-3	2014	METHODS: The immunohistochemical expression of p-Smad2 was evaluated in 78 formalin-fixed paraffin-embedded surgical resection specimens from clinical stage I to IIIA non-small cell lung cancer.	Paraffin	90-98	SMAD family member 2	Homo sapiens	49-54
28446397-4	2016	Branched DNA-liquidchip technique (bDNA-LCT) was used for detecting ASNS mRNA expression in paraffin-embedded tissue sections in the 10 cases of relapsed or refractory extranodal NK/T cell lymphoma and in 5 cases of chronic rhinitis.	Paraffin	92-100	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	68-72
24862097-1	2014	PURPOSE: Evaluation diagnostic usefulness of immunoglobulin light chains (Igkappa, Iglambda) and incomplete IGH D-J clonal gene rearrangements in formalin-fixed, paraffin-embedded (FFPE) tissue of patients with B-cell non-Hodgkin lymphomas (B-NHL).	Paraffin	162-170	immunoglobulin heavy constant delta	Homo sapiens	108-113
26861461-2	2016	EXPERIMENTAL DESIGN: The expression of SIRT6 in 60 paired paraffin-embedded HCC tissues and adjacent nontumoral liver tissues was examined by immunohistochemistry.	Paraffin	58-66	sirtuin 6	Homo sapiens	39-44
27126659-0	2016	Detection of SYT-SSX mutant transcripts in formalin-fixed paraffin-embedded sarcoma tissues using one-step reverse transcriptase real-time PCR.	Paraffin	58-66	synaptotagmin 1	Homo sapiens	13-16
27466985-3	2016	PATIENTS AND METHODS: We determined the autophagy activity in human Rb tissues by assessing the autophagy markers microtubule-associated protein light chain 3B (LC3) and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry and then associated their expression with patient clinicopathological features.	Paraffin	205-213	RB transcriptional corepressor 1	Homo sapiens	68-70
25304007-6	2014	XRCC2 protein was analyzed by immunohistochemistry for the paraffin sections of 120 CRC cases.	Paraffin	59-67	X-ray repair cross complementing 2	Homo sapiens	0-5
27126659-0	2016	Detection of SYT-SSX mutant transcripts in formalin-fixed paraffin-embedded sarcoma tissues using one-step reverse transcriptase real-time PCR.	Paraffin	58-66	SSX family member 2	Homo sapiens	17-20
25550857-3	2014	Herein, we investigated the protein expression and the clinicopathological significance of IRAK1 in 3 formalin-fixed paraffin-embedded lung cancer tissue microarrays by using immunohistochemistry, which included 365 tumor and 30 normal lung tissues.	Paraffin	117-125	interleukin 1 receptor associated kinase 1	Homo sapiens	91-96
26220827-3	2016	EphB4 and EphB6 protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 127 patients with benign (n = 71) and malignant (n = 56) thyroid lesions.	Paraffin	73-81	EPH receptor B6	Homo sapiens	10-15
25062904-6	2014	SIX1 protein mainly showed cytoplasmic/perinuclear staining pattern in breast cancer using IHC in paraffin embedded breast cancer tissues and IF in MDA-MB468 cancer cells.	Paraffin	98-106	SIX homeobox 1	Homo sapiens	0-4
27311570-5	2016	The expression of PTK6 was detected using immunohistochemical staining in 150 formalin-fixed, paraffin-embedded, early-stage cervical squamous cell cancer sections and 10 normal cervical tissue sections.	Paraffin	94-102	protein tyrosine kinase 6	Homo sapiens	18-22
26883017-3	2016	Using immunohistochemistry, we determined C14orf166 expression in paraffin-embedded tissues from 121 breast cancer patients.	Paraffin	66-74	RNA transcription, translation and transport factor	Homo sapiens	42-51
27371849-3	2016	In addition, immunohistochemistry was used to evaluate the expression and location of IL-33 on paraffin sections in selected 12 cases with different pathological types, to analyze the correlation of IL-33 expression with clinicopathological variables and overall survival.	Paraffin	95-103	interleukin 33	Homo sapiens	86-91
25567595-2	2014	METHODS: CD123 expression was evaluated by EliVision immunohistochemical staining in formalin-fixed and paraffin-embedded tissues from 30 cases of Kikuchi"s disease, 5 cases of T cell lymphoma, 10 cases of reactive lymphoid hyperplasia and 10 cases of chronic tonsillitis.	Paraffin	104-112	interleukin 3 receptor subunit alpha	Homo sapiens	9-14
26907767-8	2016	Immunohistochemical staining on formalin-fixed paraffin-embedded tissues available in our cohort of patients confirmed higher PYGM expression in normal breast tissue compared to equivalent tumoral zone.	Paraffin	47-55	glycogen phosphorylase, muscle associated	Homo sapiens	126-130
25120655-5	2014	In the present study, the expression levels of miR-320a were investigated in 15 paraffin-embedded in situ breast carcinoma and 130 invasive breast cancer tissues, and the prognostic value for breast cancer patients was assessed.	Paraffin	80-88	microRNA 320a	Homo sapiens	47-55
27223112-3	2016	AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms.	Paraffin	160-168	interleukin 1 receptor like 1	Homo sapiens	103-107
26383518-4	2016	Immunohistochemistry was applied to analyze the protein expression level of DCLK1 and Lgr5 in paraffin-embedded CRC tissues.	Paraffin	94-102	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	86-90
26442717-8	2016	In the 145 paraffin-embedded samples, CD133+ colorectal cancer was also associated with local recurrence of tumorigenesis (p=0.035) and distant metastasis (p=0.017), while patients with over 5% CD133+ tumor cells exhibited a decreased survival rate (p=0.001).	Paraffin	11-19	prominin 1	Homo sapiens	38-43
27837631-4	2016	Molecular-genetic study of MyD88 L265P gene polymorphism was done by isolation of genomic DNA from paraffin embedded tissue by means of polymerase chain reaction (PCR).	Paraffin	99-107	MYD88 innate immune signal transduction adaptor	Homo sapiens	27-32
25007965-6	2014	Antibodies against ERbeta variants were validated for staining specificity in cell lines by siRNA knockdown of ESR2 and staining reproducibility on formalin-fixed paraffin-embedded tissue by quantitative immunofluorescence (QIF) using AQUA technology.	Paraffin	163-171	estrogen receptor 2	Homo sapiens	19-25
25009592-4	2014	Paraffin immunohistochemistry revealed: an exclusively cytoplasmic granular expression of ALK; CD138, immunoglobulin A (IgA) and CD79alpha positivity; and focal expression of multiple myeloma oncogene 1 (Mum-1), CD30 and epithelial membrane antigen (EMA).	Paraffin	0-8	syndecan 1	Homo sapiens	95-100
25009592-4	2014	Paraffin immunohistochemistry revealed: an exclusively cytoplasmic granular expression of ALK; CD138, immunoglobulin A (IgA) and CD79alpha positivity; and focal expression of multiple myeloma oncogene 1 (Mum-1), CD30 and epithelial membrane antigen (EMA).	Paraffin	0-8	interferon regulatory factor 4	Homo sapiens	175-202
25009592-4	2014	Paraffin immunohistochemistry revealed: an exclusively cytoplasmic granular expression of ALK; CD138, immunoglobulin A (IgA) and CD79alpha positivity; and focal expression of multiple myeloma oncogene 1 (Mum-1), CD30 and epithelial membrane antigen (EMA).	Paraffin	0-8	interferon regulatory factor 4	Homo sapiens	204-209
27325258-3	2016	Here, we provide a protocol to perform immunostaining for phospho-H2AX on cells, cryosections and formalin-fixed, paraffin-embedded tissues.	Paraffin	114-122	H2A.X variant histone	Homo sapiens	66-70
24961466-6	2014	Immunohistochemical analysis showed a high expression of SRPK1 in 132 paraffin samples of patients with breast cancer; statistical analyses demonstrated that high expression of SRPK1 significantly correlated with clinical staging of patients with breast cancer (P &lt; 0.001), TNM classification (P &lt; 0.05).	Paraffin	70-78	SRSF protein kinase 1	Homo sapiens	57-62
26770238-3	2015	METHODS: The expression of miR-370 was determined with quantitative real-time polymerase chain reaction in 60 formalin-fixed, paraffin-embedded primary breast cancer tissues.	Paraffin	126-134	microRNA 370	Homo sapiens	27-34
26708178-6	2015	In this paper we have evaluated the GPX4 and GPX7 expression in some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC by immunohistochemistry and RT-qPCR analysis.	Paraffin	69-77	glutathione peroxidase 7	Homo sapiens	45-49
26499152-4	2015	Meanwhile NEK-6 expression in 94 paraffin samples of gastric cancer tissues was examined by immunohistochemistry and its positivity was compared among different clinicopathologic features.	Paraffin	33-41	NIMA related kinase 6	Homo sapiens	10-15
25120750-4	2014	The expression of CD133 and nestin was measured by systematic random sampling in stained paraffin sections from 239 glioma patients diagnosed between 2005 and 2009.	Paraffin	89-97	prominin 1	Homo sapiens	18-23
26297962-4	2015	Members of the miR-17 family were evaluated for expression in a vulvar tumor cell line (SW954) and 20 HPV negative formalin-fixed paraffin-embedded (FFPE) samples by quantitative real-time PCR (qRT-PCR).	Paraffin	130-138	microRNA 17	Homo sapiens	15-21
24483941-2	2014	MnSOD expression was analyzed immunohistochemically in 48 formalin-fixed and paraffin-embedded specimens from patients with UC who had undergone endoscopical biopsy.	Paraffin	77-85	superoxide dismutase 2	Homo sapiens	0-5
26499152-7	2015	In 94 paraffin samples, positive expression rate of NEK-6 was 60.6%(57/94), and NEK-6 expression was significantly associated with gastric cancer distant metastasis, lymph nodes metastasis and TNM staging(all P&lt;0.05).	Paraffin	6-14	NIMA related kinase 6	Homo sapiens	52-57
26377392-10	2015	Using light microscopy with computed morphometry for quantitative analysis, OXTR expressions were estimated in calibrated areas of the paraffin sections.	Paraffin	135-143	oxytocin receptor	Homo sapiens	76-80
24627131-5	2014	Additionally, NRP-1 protein expression in 139 archived paraffin-embedded BC samples was analyzed by immunohistochemistry and correlated with clinicopathological characteristics and survival.	Paraffin	55-63	neuropilin 1	Homo sapiens	14-19
26141041-4	2015	The expression of Ring1 was evaluated using Western blot analysis in 8 paired fresh HCC tissues and immunohistochemistry on 98 paraffin-embedded sections from 2005 to 2008.	Paraffin	127-135	ring finger protein 1	Homo sapiens	18-23
24708788-3	2014	METHODS: The protein and mRNA levels of MIF in paraffin-embedded human PC samples, chronic pancreatitis specimens, and normal pancreas were measured by immunohistochemistry and quantitative reverse-transcriptase polymerase chain reaction.	Paraffin	47-55	macrophage migration inhibitory factor	Homo sapiens	40-43
26429515-0	2015	Ultra-Tuning of the Rare-Earth fcu-MOF Aperture Size for Selective Molecular Exclusion of Branched Paraffins.	Paraffin	99-108	lysine acetyltransferase 8	Homo sapiens	35-38
25964093-5	2015	Immunohistochemistry was performed to examine c14orf166 protein expression in archived paraffin-embedded tumor samples from 109 patients with clinicopathologically confirmed NPC.	Paraffin	87-95	RNA transcription, translation and transport factor	Homo sapiens	46-55
24656090-2	2014	SDC1 levels were analyzed in 213 samples (119 paraffin-embedded and 79 serum samples of BC patients and 15 controls) using immunohistochemistry and enzyme-linked immunosorbent assay.	Paraffin	46-54	syndecan 1	Homo sapiens	0-4
26429515-3	2015	The newly constructed RE (Y(3+) and Tb(3+)) fcu-MOF analogues display unprecedented total exclusion of branched paraffins from normal paraffins.	Paraffin	112-121	lysine acetyltransferase 8	Homo sapiens	48-51
26429515-3	2015	The newly constructed RE (Y(3+) and Tb(3+)) fcu-MOF analogues display unprecedented total exclusion of branched paraffins from normal paraffins.	Paraffin	134-143	lysine acetyltransferase 8	Homo sapiens	48-51
24529991-5	2014	We show that DBs specifically detect the activated HER2/HER3 complex in formalin-fixed, paraffin-embedded cancer cells and exhibit superior detection specificity for phospho-HER3 compared to the corresponding monoclonal antibody.	Paraffin	88-96	erb-b2 receptor tyrosine kinase 3	Homo sapiens	56-60
26516944-5	2015	Real-time polymerase chain reaction to detect the ASPSCR1-TFE3 fusion transcript on paraffin-embedded tissue blocks has been shown to be more sensitive and specific than detection of TFE3 by immunohistochemical stain.	Paraffin	84-92	transcription factor binding to IGHM enhancer 3	Homo sapiens	58-62
24696733-2	2014	This study was to evaluate the potential predictive value of miR-98 expression in formalin-fixed paraffin-embedded tissue of breast cancer patients.	Paraffin	97-105	microRNA 98	Homo sapiens	61-67
24696733-9	2014	These results suggest that over-expression of miR-98 in formalin-fixed paraffin-embedded tissues might serve as a valuable source for biomarker discovery in breast cancer patients.	Paraffin	71-79	microRNA 98	Homo sapiens	46-52
26305455-5	2015	Immunohistochemistry (IHC) was performed to analyze PTOV1 protein expression in paraffin-embedded tissues from 123 patients.	Paraffin	80-88	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	52-57
26248586-4	2015	Immunohistochemical analysis revealed that RCCs exhibited higher levels of CENPH expression than normal renal tissues in paraffin-embedded archival specimens.	Paraffin	121-129	centromere protein H	Homo sapiens	75-80
26167763-3	2015	The composites filled with 50 wt% of the Fe-Co/NPC-2.0 samples in paraffin show a maximum reflection loss (RL) of -21.7 dB at a thickness of 1.2 mm; in addition, a broad absorption bandwidth for RL &lt; -10 dB which covers from 12.2 to 18 GHz can be obtained, and its minimum reflection loss and bandwidth (RL values exceeding -10 dB) are far greater than those of commercial carbonyl iron powder under a very low thickness (1-1.5 mm).	Paraffin	66-74	NPC intracellular cholesterol transporter 2	Homo sapiens	47-52
26268359-4	2015	We tested KIF5B-RET translocation in Formalin Fixed Paraffin Embedded using fluorescence in situ hybridization.	Paraffin	52-60	kinesin family member 5B	Homo sapiens	10-15
24695631-4	2014	The expression level of LMTK3 in 69 archival paraffin-embedded colorectal tumor tissue specimens was examined by immunohistochemistry (IHC).	Paraffin	45-53	lemur tyrosine kinase 3	Homo sapiens	24-29
25907264-6	2015	We demonstrate histopathological findings and confirm the HEY1-NCOA2 gene fusion in a formalin-fixed paraffin-embedded archival sample using simple reverse transcription polymerase chain reaction (RT-PCR) method.	Paraffin	101-109	nuclear receptor coactivator 2	Homo sapiens	63-68
24463084-5	2014	Immunohistochemical staining was conducted of CD74 on paraffin-embedded tumor sample slices.	Paraffin	54-62	CD74 molecule	Homo sapiens	46-50
25545408-5	2015	METHODS: Immunohistochemistry was used to investigate expression of WRN in formalin-fixed, paraffin wax-embedded tissue specimens of 9 squamous cell carcinoma (SCC), 15 actinic keratosis (AK), 11 Bowen disease (BD) and 11 normal-appearing peripheral tissue samples, obtained from patients during surgical resections.	Paraffin	91-103	WRN RecQ like helicase	Homo sapiens	68-71
24281232-3	2014	STUDY DESIGN: Arginase-1 and HepPar-1 IHC was performed on formalin-fixed, paraffin-embedded fine needle aspiration (FNA) cell blocks (CB) of PAD (n = 46), tissue microarray (TMA) of PAD (n = 33), FNA CB of HCC (n = 44) and TMA of HCC (n = 85).	Paraffin	75-83	arginase 1	Homo sapiens	14-41
26035311-3	2015	By switching the prenucleated metals to form robust Co-Pd or Co-Cu bimetallic nanocatalysts, the selectivity of CO hydrogenation could be adjusted purposely towards heavy paraffins, light olefins or oxygenates.	Paraffin	171-180	COPD	Homo sapiens	52-57
25883126-8	2015	The expression of norepinephrine transporter (NET) and vesicular monoamine transporter (VMAT-1) was evaluated immunohistochemically in paraffin-embedded tumor tissues.	Paraffin	135-143	solute carrier family 18 member A1	Homo sapiens	88-94
26109910-3	2015	METHODS: MiR-203 expression in 95 formalin-fixed, paraffin embedded (FFPE) HCC tissues and their paired adjacent non-cancerous tissues was evaluated by quantitative reverse transcription polymerase chain reaction (qRT-PCR).	Paraffin	50-58	microRNA 203a	Homo sapiens	9-16
26091472-7	2015	HRs results of TP slides and those of formalin-fixed paraffin-embedded (FFPE) slides were correlated well for ER (concordance rate =  3.3%, kappa value = 0.85) and PR (concordance rate = 88.6%, kappa value = 0.75).	Paraffin	53-61	progesterone receptor	Homo sapiens	164-166
25870121-3	2015	The expression of PAUF was immunohistochemically determined in 345 formalin-fixed, paraffin-embedded cervical cancer tissues and 107 normal cervical epitheliums.	Paraffin	83-91	zymogen granule protein 16B	Homo sapiens	18-22
24935362-2	2014	MATERIALS AND METHODS: We have designed four gene molecular beacon (MB) probes for multiplex quantitative real-time polymerase chain reactions to examine RRM1, XRCC1, TUBB3 and TS mRNA expression in paraffin-embedded specimens from 50 patients with advanced or metastatic carcinomas.	Paraffin	199-207	ribonucleotide reductase catalytic subunit M1	Homo sapiens	154-158
24935362-2	2014	MATERIALS AND METHODS: We have designed four gene molecular beacon (MB) probes for multiplex quantitative real-time polymerase chain reactions to examine RRM1, XRCC1, TUBB3 and TS mRNA expression in paraffin-embedded specimens from 50 patients with advanced or metastatic carcinomas.	Paraffin	199-207	tubulin beta 3 class III	Homo sapiens	167-172
24265557-2	2013	METHODS: B7-H3 expression patterns were compared between cancer and paired adjacent normal renal parenchyma by immunohistochemistry in paraffin-embedded specimens from 200 consecutive patients with clear cell renal cell carcinoma from January to December 2010.	Paraffin	135-143	CD276 molecule	Homo sapiens	9-14
25843803-2	2015	The correlation of TRIM16 expression and clinical features of NSCLC was analyzed in paraffin-embedded archived normal lung tissues and NSCLC tissues by immunohistochemical analysis.	Paraffin	84-92	tripartite motif containing 16	Homo sapiens	19-25
23664661-4	2013	Immunohistochemical analysis revealed that paraffin-embedded archival CCRCC specimens exhibited higher levels of OIP5 expression than normal renal tissues.	Paraffin	43-51	Opa interacting protein 5	Homo sapiens	113-117
25809616-3	2015	Poteligeo Test IHC (CCR4 staining kit) is a newly developed staining kit that can examine the presence of CCR4 expressed on tumor cells of adult T-cell leukemia/lymphoma, peripheral T-cell lymphoma and cutaneous T-cell lymphoma before treatment of anti-CCR4 antibody using paraffin-embedded samples.	Paraffin	273-281	C-C motif chemokine receptor 4	Homo sapiens	20-24
25809616-3	2015	Poteligeo Test IHC (CCR4 staining kit) is a newly developed staining kit that can examine the presence of CCR4 expressed on tumor cells of adult T-cell leukemia/lymphoma, peripheral T-cell lymphoma and cutaneous T-cell lymphoma before treatment of anti-CCR4 antibody using paraffin-embedded samples.	Paraffin	273-281	C-C motif chemokine receptor 4	Homo sapiens	106-110
25809616-3	2015	Poteligeo Test IHC (CCR4 staining kit) is a newly developed staining kit that can examine the presence of CCR4 expressed on tumor cells of adult T-cell leukemia/lymphoma, peripheral T-cell lymphoma and cutaneous T-cell lymphoma before treatment of anti-CCR4 antibody using paraffin-embedded samples.	Paraffin	273-281	C-C motif chemokine receptor 4	Homo sapiens	106-110
25940978-5	2015	CXCL12 was validated by immunohistochemistry in paraffin-embedded cervical cancer tissues before radiotherapy.	Paraffin	48-56	C-X-C motif chemokine ligand 12	Homo sapiens	0-6
26155204-8	2015	The result of PCR genotyping with extracted DNA from the paraffin sections showed existence of 10 Pdx1-knockout mice and corresponded to results of immunostaining.	Paraffin	57-65	pancreatic and duodenal homeobox 1	Mus musculus	98-102
23528862-9	2013	Immunohistochemical staining with CD133 and other biomarkers has been used to characterize thyroid cancer stem-like cells in paraffin sections of thyroid cancers.	Paraffin	125-133	prominin 1	Homo sapiens	34-39
25535872-4	2015	Fascin expression was examined through the immunohistochemistry of paraffin embedded tissue microarrays including 560 cores of primary tumour and metastasis.	Paraffin	67-75	fascin actin-bundling protein 1	Homo sapiens	0-6
23947899-3	2013	METHODS: Cyclin D1 immunohistochemical analysis (IHC) was used to evaluate 201 fixed, paraffin-embedded endometrial samples which included simple hyperplasia (n = 27), atypical complex hyperplasia (ACH) (n = 41), endometrioid carcinoma (n = 103), endometrial serous carcinoma (ESC) (n = 21) and clear cell carcinoma (CCC) (n = 9).	Paraffin	86-94	cyclin D1	Homo sapiens	9-18
24707321-6	2013	Reverse transcription-polymerase chain reaction using paraffin sections amplified a SYT-SSX1 chimera transcript.	Paraffin	54-62	synaptotagmin 1	Homo sapiens	84-87
25993328-4	2015	The aim of our study is to provide a recommendation and report on pitfalls in the use of phospho-specific antibodies against mTORC1-targets phospho-RPS6 (Ser235/236; Ser240/244) and phospho-4EBP1 (Thr37/46) in formalin fixed, paraffin embedded material.	Paraffin	226-234	CREB regulated transcription coactivator 1	Mus musculus	125-131
25569410-8	2015	Thyroglobulin and thyroid transcription factor 1 stains displayed a strong staining on paraffin block.	Paraffin	87-95	thyroglobulin	Homo sapiens	0-13
24748127-7	2014	In formalin-fixed paraffin-embedded and microdissected frozen samples, miR-373 expression was significantly down-regulated in pancreatic cancer compared with that in healthy pancreas (P &lt; 0.001 and P = 0.005, respectively).	Paraffin	18-26	microRNA 373	Homo sapiens	71-78
26150155-11	2015	In summary, we present a specific and reliable IHC staining of LC3B and p62 on formalin fixed and paraffin embedded human tissue.	Paraffin	98-106	microtubule associated protein 1 light chain 3 beta	Homo sapiens	63-67
24284254-3	2013	The expression of URGCP in 278 paraffin-embedded, archived clinical HCC samples was analyzed by immunohistochemistry (IHC) and statistic analysis conducted to examine the relationship of prognosis and URGCP expression.	Paraffin	31-39	upregulator of cell proliferation	Homo sapiens	18-23
24284254-4	2013	RESULTS: IHC analysis revealed a high expression of URGCP in all HCC cell lines and in 122/278 (43.8%) paraffin-embedded archived HCC specimens.	Paraffin	103-111	upregulator of cell proliferation	Homo sapiens	52-57
25371726-6	2014	Immunohistochemical analysis showed that 88 of 133 (66.2%) paraffin-embedded NPC biopsies exhibited positive expression of CHD1L, but all non-cancerous nasopharyngeal specimens were negative for CHD1L expression.	Paraffin	59-67	chromodomain helicase DNA binding protein 1 like	Homo sapiens	123-128
23715628-4	2013	FOXE1 expression in 81 PTC paraffin-embedded blocks was also evaluated retrospectively by immunohistochemistry (IHC) and its correlation with the clinicopathological parameters of PTC patients was analyzed.	Paraffin	27-35	forkhead box E1	Homo sapiens	0-5
23826410-4	2013	Expression of the lysosomal marker LAMP-1 (lysosomal-associated membrane protein-1) was investigated by immunohistochemistry in 112 formalin fixed paraffin embedded astrocytomas and compared with tumor grade and overall patient survival.	Paraffin	147-155	lysosomal associated membrane protein 1	Homo sapiens	35-41
25925041-4	2015	The expression of Talin-1 was analyzed by immunohistochemical staining in 233 paraffin-embedded NPC specimens with clinical follow-up data and cox regression analysis was used to identify independent prognostic factors.	Paraffin	78-86	talin 1	Homo sapiens	18-25
24737069-4	2014	METHODS/PATIENTS: Stromal expression of CA IX in 361 formalin-fixed, paraffin-embedded specimens of invasive esophageal cancers, 206 adenocarcinoma (AC) and 155 squamous cell carcinoma (SCC), was investigated.	Paraffin	69-77	carbonic anhydrase 9	Homo sapiens	40-45
24990775-3	2015	PRLR expression was analyzed in 63 paraffin-embedded biopsies of uterine cervical tissue.	Paraffin	35-43	prolactin receptor	Homo sapiens	0-4
25536568-14	2014	Consequently the I-FISH method allows identification of of MYC and IGH gene rearrangements in tissue cells substrate of lymphoma fixed in paraffin.	Paraffin	138-146	immunoglobulin heavy locus	Homo sapiens	67-70
23161183-3	2013	Podoplanin expression was investigated immunohistochemically in 200 formalin-fixed, paraffin embedded specimens of invasive esophagal ACs, their corresponding metastases and 35 precursor lesions.	Paraffin	84-92	podoplanin	Homo sapiens	0-10
25582503-2	2015	We examined variations of the NAB2-STAT6 fusion gene in 40 cases of SFT using formalin-fixed, paraffin-embedded tissues and secondary genetic alterations of tumor protein p53 (TP53),, platelet-derived growth factor receptor, beta polypeptide (PDGFRB), and telomerase reverse transcriptase (TERT) promoters.	Paraffin	94-102	NGFI-A binding protein 2	Homo sapiens	30-34
23143646-2	2013	METHODS: The protein expression of FAK was investigated in 153 paraffin-embedded tissues by immunohistochemical analysis and then correlated with various clinicopathologic parameters.	Paraffin	63-71	protein tyrosine kinase 2	Homo sapiens	35-38
24982352-4	2014	MATERIALS AND METHODS: Evaluation of the cytoplasmic expression of PROX1 in normal gastric mucosa and gastric cancer was performed by IHC followed by RNAscope, an in situ hybridization-based method for detecting PROX1 mRNA amplification on paraffin-embedded samples and to evaluate its clinical impact.	Paraffin	240-248	prospero homeobox 1	Homo sapiens	67-72
23161413-3	2013	By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with bipolar disorder.	Paraffin	88-96	phospholipase C beta 1	Homo sapiens	79-84
24649153-9	2013	As expression of miR-486 was measured from formalin-fixed paraffin-embedded (FFPE) samples, this study demonstrated that measurement of miR-486 may be readily translated into clinical applications.	Paraffin	58-66	microRNA 486-1	Homo sapiens	17-24
25548443-1	2015	This study investigates PCR analysis of immunoglobulin heavy chain (IgH) and T cell receptor (TCR) gene rearrangements on paraffin-embedded tissue sections and bone marrow aspirates of patients suspected to have lymphoproliferative disorders but with inconclusive diagnosis in histopathological examination.	Paraffin	122-130	immunoglobulin heavy constant delta	Homo sapiens	40-66
24414991-4	2014	RING1 expression was evaluated by Immunoblot in 8 paired fresh lung cancer tissues and immunohistochemistry on 69 paraffin-embedded sections from 2006 to 2009.	Paraffin	114-122	ring finger protein 1	Homo sapiens	0-5
25548443-1	2015	This study investigates PCR analysis of immunoglobulin heavy chain (IgH) and T cell receptor (TCR) gene rearrangements on paraffin-embedded tissue sections and bone marrow aspirates of patients suspected to have lymphoproliferative disorders but with inconclusive diagnosis in histopathological examination.	Paraffin	122-130	immunoglobulin heavy constant delta	Homo sapiens	68-71
23569128-2	2013	METHODS: To evaluate the prognostic significance of downregulated PCDH10 protein levels, immunohistochemistry was used to assess the level of PCDH10 protein in surgically-resected formalin-fixed, paraffin wax-embedded transitional cell carcinoma specimens.	Paraffin	196-208	protocadherin 10	Homo sapiens	142-148
24977712-4	2014	Expression of TLR4 and MyD88 was assessed immunohistochemically in 198 paraffin-embedded ovarian tissues and in an embryonal carcinoma model of cancer stemness.	Paraffin	71-79	MYD88 innate immune signal transduction adaptor	Homo sapiens	23-28
23262439-4	2013	The expression of JARID1B was evaluated by immunohistochemistry in formalin-fixed paraffin-embedded samples of 30 nevi, 27 primary melanomas, four lymph node metastases, and one local recurrence of melanoma.	Paraffin	82-90	lysine demethylase 5B	Homo sapiens	18-25
25684949-3	2015	The protein expression of FGFR4 in formalin-fixed, paraffin-embedded (FFPE) GC tissues was determined by immunohistochemical (IHC) analysis.	Paraffin	51-59	fibroblast growth factor receptor 4	Homo sapiens	26-31
23912258-4	2014	RFC expression was assessed using a two-step model of immunohistochemical staining in paraffin-embedded tissue samples.	Paraffin	86-94	solute carrier family 19 member 1	Homo sapiens	0-3
25155396-6	2015	METHODS: Computer-assisted whole-slide analysis, together with enzymatic epitope retrieval, was used for CD31-based microvessel quantification in 131 pretreatment formalin-fixed and paraffin-embedded biopsies from three bone tumor centers.	Paraffin	182-190	platelet and endothelial cell adhesion molecule 1	Homo sapiens	105-109
25973068-3	2015	Lgr5 protein expression was evaluated by immunohistochemistry in 94 paraffin-embedded cervical carcinoma specimens.	Paraffin	68-76	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	0-4
25973071-3	2015	Immunohistochemistry was performed to evaluation of STOML2 expression in 94 paraffin-embedded cervical cancer samples.	Paraffin	76-84	stomatin like 2	Homo sapiens	52-58
22595948-11	2013	These results demonstrate that mouse monoclonal PAX8 [BC12] stains nuclei exclusively and performs well in formalin-fixed paraffin-embedded tissues.	Paraffin	122-130	paired box 8	Homo sapiens	48-52
24435655-5	2014	Immunohistochemical analysis also showed strong membranous and cytoplasmic localization of CD71 in paraffin-embedded tumors.	Paraffin	99-107	transferrin receptor	Homo sapiens	91-95
24596534-2	2013	MATERIAL AND METHODS: In the present work, the expression of HER-3 in a group of 35 HER-2 positive patients with BC was studied by performing immunohistochemistry (IHC) in formalin-fixed paraffin embedded tissues.	Paraffin	187-195	erb-b2 receptor tyrosine kinase 3	Homo sapiens	61-66
23841222-0	2013	Detection of the epidermal growth factor receptor, amphiregulin and epiregulin in formalin-fixed paraffin-embedded human placenta tissue by matrix-assisted laser desorption/ionization mass spectrometry imaging.	Paraffin	97-105	epiregulin	Homo sapiens	68-78
25384402-7	2015	Paraffin slices were labeled with p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) by immunofluorescence staining, and then were co-labeled with hexaribonucleotide binding protein-3 (NeuN), glial fibrillary acidic protein (GFAP) and anti-integrin alphaM (CD11b) antibody (OX-42) to explore the associations of p38MAPK and JNK with nerve cells or glial cell.	Paraffin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	34-70
25384402-7	2015	Paraffin slices were labeled with p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) by immunofluorescence staining, and then were co-labeled with hexaribonucleotide binding protein-3 (NeuN), glial fibrillary acidic protein (GFAP) and anti-integrin alphaM (CD11b) antibody (OX-42) to explore the associations of p38MAPK and JNK with nerve cells or glial cell.	Paraffin	0-8	mitogen activated protein kinase 14	Rattus norvegicus	72-79
24333852-5	2014	We first converted this antibody into bivalent IgG, and verified its ability to recognize PAPP-A in sections of formalin-fixed and paraffin-embedded tissue.	Paraffin	131-139	pappalysin 1	Homo sapiens	90-96
25286760-5	2015	The expression of NF45 was evaluated by Western blot in 8 paired fresh ESCC tissues and immunohistochemistry on 105 paraffin-embedded slices.	Paraffin	116-124	interleukin enhancer binding factor 2	Homo sapiens	18-22
23137022-4	2012	The analysis of syndecan-1 expression in liver biopsies was performed by immunohistochemistry on formalin-fixed, paraffin-embedded samples.	Paraffin	113-121	syndecan 1	Homo sapiens	16-26
25016705-2	2014	METHODS: The presence of the Bcl-2/IgH fusion gene was detected in BM samples and paraffin-embedded lymph node (LN) samples from 103 patients with DLBCLs using FISH.	Paraffin	82-90	immunoglobulin heavy locus	Homo sapiens	35-38
25016705-4	2014	RESULTS: Bcl-2/IgH translocation in paraffin-embedded LN tissue sections was observed in 43 (41.7%) patients by FISH.	Paraffin	36-44	immunoglobulin heavy locus	Homo sapiens	15-18
24276989-4	2014	Foxp3+ TILs as well as CD8+ ones were detected by immunohistochemistry on paraffin-embedded tumor samples from 62 patients.	Paraffin	74-82	forkhead box P3	Homo sapiens	0-5
23009111-3	2012	The real-time quantitative reverse transcription-polymerase chain reaction was carried out to detect TLR9 expression in 41 formalin-fixed paraffin-embedded samples.	Paraffin	138-146	toll like receptor 9	Homo sapiens	101-105
25452807-3	2015	The protein expression levels of DPC4/Smad4 were detected by immunohistochemistry in paraffin-embedded samples of NSCLC.	Paraffin	85-93	SMAD family member 4	Homo sapiens	33-37
25452807-3	2015	The protein expression levels of DPC4/Smad4 were detected by immunohistochemistry in paraffin-embedded samples of NSCLC.	Paraffin	85-93	SMAD family member 4	Homo sapiens	38-43
23741244-14	2012	EWS-WT1 fusion transcripts were detected in 3 out of 4 cases, but not in any other tumor types studied as controls using paraffin-embedded tissue by FISH.	Paraffin	121-129	EWS RNA binding protein 1	Homo sapiens	0-3
24527533-2	2014	METHODS: We determined the expressions of Cx26, Cx32 and Cx43 in the paraffin samples from 31 cases of PCa and 23 cases of BPH by SABC immunohistochemical staining, and analyzed the relationship of their expressions with the clinical and pathological parameters of PCa and BPH using the semiquantitative method.	Paraffin	69-77	gap junction protein alpha 1	Homo sapiens	57-61
22862905-7	2012	The presence of an SYT-SSX1 and/or SYT-SSX2 gene fusion resulting from t(X;18) was demonstrated from paraffin blocks by reverse transcriptase polymerase chain reaction in five cases.	Paraffin	101-109	synaptotagmin 1	Homo sapiens	19-22
24391982-7	2013	DKK1 protein expression was also evaluated in paraffin sections from 102 patients with NSCLC by immunohistochemistry, and 65(63.73%)tumors were DKK1 positive.	Paraffin	46-54	dickkopf WNT signaling pathway inhibitor 1	Homo sapiens	0-4
22862905-7	2012	The presence of an SYT-SSX1 and/or SYT-SSX2 gene fusion resulting from t(X;18) was demonstrated from paraffin blocks by reverse transcriptase polymerase chain reaction in five cases.	Paraffin	101-109	synaptotagmin 1	Homo sapiens	35-38
22862905-7	2012	The presence of an SYT-SSX1 and/or SYT-SSX2 gene fusion resulting from t(X;18) was demonstrated from paraffin blocks by reverse transcriptase polymerase chain reaction in five cases.	Paraffin	101-109	SSX family member 2	Homo sapiens	39-43
24602014-3	2015	METHODS: CD1a immunoreactivity was used to identify lesional cells in archival paraffin-embedded samples of cutaneous LCH.	Paraffin	79-87	CD1a molecule	Homo sapiens	9-13
23836289-3	2013	The density of intratumoral FOXP3+ lymphocytes in paraffin-embedded tissues was assessed by immunohistochemical analyses in appropriate cases.	Paraffin	50-58	forkhead box P3	Homo sapiens	28-33
26191531-8	2015	Dual label immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue revealed reduced expression of tropoelastin in LANA positive spindle cell regions quantified by Ariol SL-50 scanning analysis.	Paraffin	50-58	LANA	Human gammaherpesvirus 8	128-132
20863722-0	2012	Paraffin-embedded tissue is less accurate than frozen section analysis for determining VHL mutational status in sporadic renal cell carcinoma.	Paraffin	0-8	von Hippel-Lindau tumor suppressor	Homo sapiens	87-90
20863722-10	2012	VHL mutations were found in 52.1% of the whole paraffin samples whereas 98% were mutated; 72% could be sequenced, resulting in 69.1% of VHL mutations in this subset.	Paraffin	47-55	von Hippel-Lindau tumor suppressor	Homo sapiens	0-3
20863722-14	2012	CONCLUSION: Tumoral DNA extraction and VHL mutation analysis can be performed from formalin-fixed paraffin-embedded (FFPE) tissue in RCC.	Paraffin	98-106	von Hippel-Lindau tumor suppressor	Homo sapiens	39-42
23784051-3	2013	METHODS: We examined Lgr5 expression in 384 formalin-fixed paraffin-embedded CRC specimens from 296 CRC patients, including 64 patients treated with 5-fluorouracil (5-FU)-based chemotherapy.	Paraffin	59-67	leucine rich repeat containing G protein-coupled receptor 5	Homo sapiens	21-25
22490335-5	2012	This miRNA classifier showed consistent results in formalin-fixed paraffin-embedded tissues and was able to distinguish cyclin D1-negative MCL from other lymphomas.	Paraffin	66-74	cyclin D1	Homo sapiens	120-129
25634174-6	2015	Immunohistochemistry assays assessed PTOV1 protein expression in paraffin-embedded clinical samples taken from 215 HCC patients.	Paraffin	65-73	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	37-42
25634174-9	2015	In the paraffin-embedded tissue samples from 215 HCC patients, PTOV1 protein expression was significantly correlated with T classification, N classification, clinical stage, and serum alpha-fetoprotein.	Paraffin	7-15	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	63-68
24053422-4	2013	Immunohistochemical staining for TUBB3 and ERCC1 was performed using paraffin wax-embedded tumor tissues.	Paraffin	69-81	tubulin beta 3 class III	Homo sapiens	33-38
26278137-4	2015	BCSC-1 expression was detected in ESCC and normal tissues adjacent to tumor tissues by Western blot analysis and real-time PCR  as well as immunohistochemistry of paraffin sections.	Paraffin	163-171	von Willebrand factor A domain containing 5A	Homo sapiens	0-6
22159627-3	2012	METHODS: In our study, protein expression levels of SGLT1 were explored by semiquantitative immunohistochemical staining on archival formalin-fixed paraffin-embedded pathologic specimen consisting of 178 epithelial ovarian tumors.	Paraffin	148-156	major facilitator superfamily domain containing 4B	Homo sapiens	52-57
24053763-6	2013	RESULTS: Immunohistochemical analysis showed that 176 of 266 (66.17%) paraffin-embedded archival NPC biopsies showed high expression of NRP-1, but no non-cancerous nasopharyngeal specimens showed positive expression of NRP-1.	Paraffin	70-78	neuropilin 1	Homo sapiens	136-141
22382782-3	2012	Using paraffin-embedded sections from normal adult autopsy specimens and glioma resection specimens, we demonstrate that nucleolin expression is limited in the normal human brain specifically to mature neurons, ependymal cells, and granular cells of the dentate gyrus.	Paraffin	6-14	nucleolin	Homo sapiens	121-130
24903677-7	2015	In conclusion, our results reassured the high specificity of annexin A1 and pERK, as well as the diagnostic value of standard HCL markers of CD11c, CD25, CD103, and CD123 also in paraffin-embedded BM samples.	Paraffin	179-187	integrin subunit alpha X	Homo sapiens	141-146
24903677-7	2015	In conclusion, our results reassured the high specificity of annexin A1 and pERK, as well as the diagnostic value of standard HCL markers of CD11c, CD25, CD103, and CD123 also in paraffin-embedded BM samples.	Paraffin	179-187	interleukin 2 receptor subunit alpha	Homo sapiens	148-152
24903677-7	2015	In conclusion, our results reassured the high specificity of annexin A1 and pERK, as well as the diagnostic value of standard HCL markers of CD11c, CD25, CD103, and CD123 also in paraffin-embedded BM samples.	Paraffin	179-187	interleukin 3 receptor subunit alpha	Homo sapiens	165-170
24053763-6	2013	RESULTS: Immunohistochemical analysis showed that 176 of 266 (66.17%) paraffin-embedded archival NPC biopsies showed high expression of NRP-1, but no non-cancerous nasopharyngeal specimens showed positive expression of NRP-1.	Paraffin	70-78	neuropilin 1	Homo sapiens	219-224
21800286-3	2012	METHODS: Total FAK expression was analyzed via immunohistochemistry in tissue microarrays consisting of formalin-fixed, paraffin-embedded SCLC specimens from 85 patients.	Paraffin	120-128	protein tyrosine kinase 2	Homo sapiens	15-18
23354604-8	2013	With the tempol pre-treatment, the immunoreactivity of COX-2 and nitrotyrosine in paraffin-embedded tissue slices was profoundly decreased.	Paraffin	82-90	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	55-60
21835426-8	2012	Thus, detection of the ASPSCR1-TFE3 fusion transcript was considered applicable for formalin-fixed, paraffin-embedded tissues with superior sensitivity as compared with TFE3 immunohistochemical staining.	Paraffin	100-108	transcription factor binding to IGHM enhancer 3	Homo sapiens	31-35
25481017-0	2014	Detection of immunoglobulin IGH gene rearrangements on formalin-fixed, paraffin embedded tissue in lymphoid malignancies.	Paraffin	71-79	immunoglobulin heavy locus	Homo sapiens	28-31
24332055-4	2013	The expression of ERalpha and ERbeta was analyzed by immunohistochemistry on paraffin-embedded sections.	Paraffin	77-85	estrogen receptor 2	Homo sapiens	30-36
23643873-6	2013	Immunochemistry analysis showed that M-CSFR(+) cells located in all tested paraffin-embedded tissues and M-CSFR(+) cell centres with the characteristic of melano-macrophage centres(MMCs) was found in the spleen, head kidney, kidney, gut and liver.	Paraffin	75-83	colony stimulating factor 1 receptor	Homo sapiens	39-43
25305095-3	2014	In this study, we established a robust assay for the detection of SRSF2 mutations in decalcified, paraffin-embedded bone marrow (BM) biopsies and investigated its diagnostic utility.	Paraffin	98-106	serine and arginine rich splicing factor 2	Homo sapiens	66-71
22098598-11	2012	Reverse transcriptase polymerase chain reaction (RT-PCR) of a paraffin-embedded tissue sample revealed SYT-SSX fusion transcripts, and the diagnosis of synovial sarcoma was confirmed.	Paraffin	62-70	synaptotagmin 1	Homo sapiens	103-106
22052344-2	2012	We identified the same bcl-2/IgH fusion gene in             paraffin-embedded lymph node (LN) samples and BM samples using immunohistochemistry             (IHC), immunocytochemistry (ICC), cytologic morphology and fluorescence in situ             hybridization (FISH).	Paraffin	60-68	immunoglobulin heavy locus	Homo sapiens	29-32
22052344-5	2012	Approximately 78.6% (44/56) of             the paraffin-embedded LN tissue sections that underwent FISH analysis had a bcl-2/IgH             translocation.	Paraffin	47-55	immunoglobulin heavy locus	Homo sapiens	125-128
23905607-4	2013	Placental inflammatory activity was evaluated by quantifying immunohistochemically the levels of p65/RelA expression of nuclear transcription factor-kappa beta (NF-kB) in paraffin-embedded tissue samples.	Paraffin	171-179	RELA proto-oncogene, NF-kB subunit	Homo sapiens	101-105
22149278-7	2011	In addition, anti-MUC1-CD can be used to detect expression of the MUC1-C subunit in formalin-fixed, paraffin-embedded tissues.	Paraffin	100-108	mucin 1, cell surface associated	Homo sapiens	18-22
22149278-7	2011	In addition, anti-MUC1-CD can be used to detect expression of the MUC1-C subunit in formalin-fixed, paraffin-embedded tissues.	Paraffin	100-108	mucin 1, cell surface associated	Homo sapiens	66-70
23589362-5	2013	The increased expression of Arg1 mRNA and protein was validated by Western blot, Q-RT-PCR, paraffin tissue microarray and immunohistochemistry.	Paraffin	91-99	arginase 1	Homo sapiens	28-32
22088988-5	2011	For prognostic analysis, MALAT-1 RNA was detected on paraffin-embedded non-small cell lung cancer (NSCLC) tissue probes (n = 352) using in situ hybridization.	Paraffin	53-61	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	25-32
22088988-11	2011	In situ hybridization on paraffin-embedded lung cancer tissue probes revealed that high MALAT-1 RNA expression in squamous cell carcinoma of the lung was associated with a poor prognosis.	Paraffin	25-33	metastasis associated lung adenocarcinoma transcript 1 (non-coding RNA)	Mus musculus	88-95
25259564-4	2014	METHODS: In this study, the authors investigated MMP2 and TIMP2 gene polymorphisms in formalin-fixed paraffin-embedded tissue samples obtained from meningioma patients who had previously undergone surgery at the authors" institution.	Paraffin	101-109	matrix metallopeptidase 2	Homo sapiens	49-53
23278563-4	2013	The levels and locations of syndecan-1 and -2 immunostainings were analyzed using formalin-fixed and paraffin-embedded tissue samples of OSCC and CSCC cases together with clinical data.	Paraffin	101-109	syndecan 1	Homo sapiens	28-45
25375219-4	2014	TCF3 protein expression dynamics were detected by immunohistochemistry of 118 paraffin-embedded specimens, and the clinical significance of TCF3 was assessed by clinical correlation and Kaplan-Meier analyses.	Paraffin	78-86	transcription factor 3	Homo sapiens	0-4
22081130-6	2011	Two polymorphic loci of the APC gene were investigated for LOH and sequence analysis was performed for the mutation cluster region of the APC gene on formalin fixed, paraffin embedded samples.	Paraffin	166-174	APC regulator of WNT signaling pathway	Homo sapiens	138-141
23593387-4	2013	miR-34a expression in eighty-three cases of HCC formalin-fixed paraffin-embedded (FFPE) tissues decreased significantly compared to that in the adjacent liver tissues (P&lt;0.01), as detected by real-time quantitative RT-PCR (RT-qPCR).	Paraffin	63-71	microRNA 34a	Homo sapiens	0-7
22336504-3	2011	Genetic Leu125Val polymorphism of PECAM-1 was detected by PCR-SSCP in myocardial paraffin blocks of 37 ACS cases and 43 control cases, and Ser128Arg polymorphism of E-selectin was detected by PCR-RFLP in myocardial paraffin blocks of 39 ACS cases and 43 control cases, respectively.	Paraffin	81-89	platelet and endothelial cell adhesion molecule 1	Homo sapiens	34-41
22336504-3	2011	Genetic Leu125Val polymorphism of PECAM-1 was detected by PCR-SSCP in myocardial paraffin blocks of 37 ACS cases and 43 control cases, and Ser128Arg polymorphism of E-selectin was detected by PCR-RFLP in myocardial paraffin blocks of 39 ACS cases and 43 control cases, respectively.	Paraffin	215-223	platelet and endothelial cell adhesion molecule 1	Homo sapiens	34-41
25117073-6	2014	Immunohistochemistry (IHC) was performed to examine HSPA2 protein expression in paraffin-embedded tissues from 119 HCC patients.	Paraffin	80-88	heat shock protein family A (Hsp70) member 2	Homo sapiens	52-57
24996384-4	2014	METHODS: ISG15 expression was examined immunohistologically in paraffin-embedded human placental and decidual tissue samples of all pregnancy trimesters on adjacent sections (first trimester n = 5, second n = 5, third n = 3).	Paraffin	63-71	ISG15 ubiquitin like modifier	Homo sapiens	9-14
23531100-8	2013	We confirmed the expression of a subset of these differentially expressed genes (ANGPT2, ANTXR1, SMARCE1, RGS5, CTAG2, LTBP2, CLDN11, and KISS1) using qPCR and utilized immunohistochemistry on a panel of paraffin embedded infantile hemangioma tumor tissues to demonstrate that the cancer/testis antigen CTAG2 is highly abundant in vessel-dense proliferating infantile hemangiomas and with significantly reduced levels during tumor involution as vascular density decreases.	Paraffin	204-212	angiopoietin 2	Homo sapiens	81-87
22092403-3	2011	METHODS AND RESULTS: PR expression was examined by immunohistochemistry (n=143) and kinetic reverse transcription-polymerase chain reaction (RT-PCR) from formalin-fixed and paraffin-embedded tissue (n=55).	Paraffin	173-181	progesterone receptor	Homo sapiens	21-23
22005870-4	2011	The protein expression of VHL and Bax was investigated by means of immunohistochemical analysis of paraffin-embedded clinical specimens from seventeen benign cartilage tumors and thirty-four chondrosarcomas.	Paraffin	99-107	von Hippel-Lindau tumor suppressor	Homo sapiens	26-29
25158006-12	2014	The anti-SP-10 antibody works well in different fixatives, on paraffin-embedded as well as cryosections, and has been shown to be useful for characterizing spermatogenic defects in mutant mice.	Paraffin	62-70	acrosomal vesicle protein 1	Mus musculus	9-14
23603344-5	2013	The absolute mRNA content of paraffin embedded samples of salivary gland cancer was determined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR) using specific primers for NFkB1, GADD45A and JNK1.	Paraffin	29-37	growth arrest and DNA damage inducible alpha	Homo sapiens	203-210
23131707-5	2013	PAR-2 expression was evaluated by immunohistochemical method in formalin-fixed and paraffin-embedded tissues of surgical lung biopsies from patients with IPF.	Paraffin	83-91	F2R like trypsin receptor 1	Homo sapiens	0-5
25248672-6	2014	The P receptor (PR) mutation PROGINS was not detected in women from group A. Semi-quantitation of immunoreactive PRA/B, PRB and Sp1 (a transcription factor related to P signaling) in paraffin-embedded endometrial sections, did not show statistically significant differences amongst groups.	Paraffin	183-191	RB transcriptional corepressor 1	Homo sapiens	120-123
21670698-5	2011	The Id-1 protein was detected by immunohistochemistry and Western blot in paraffin-embedded and fresh carcinoma tissues.	Paraffin	74-82	inhibitor of DNA binding 1, HLH protein	Homo sapiens	4-8
24021782-2	2013	We used immunocytochemistry to assess the utility of chemokine CXC ligand 12 (CXCL12) as a novel diagnostic marker for PTC employing paraffin-embedded cell blocks.	Paraffin	133-141	C-X-C motif chemokine ligand 12	Homo sapiens	63-76
21887928-0	2011	[Our experience with detection of JAK2 mutations in paraffin-embedded trephine bone marrow biopsies of patients with chronic myeloproliferative disorders].	Paraffin	52-60	Janus kinase 2	Homo sapiens	34-38
24021782-2	2013	We used immunocytochemistry to assess the utility of chemokine CXC ligand 12 (CXCL12) as a novel diagnostic marker for PTC employing paraffin-embedded cell blocks.	Paraffin	133-141	C-X-C motif chemokine ligand 12	Homo sapiens	78-84
21247708-5	2011	We retrospectively analyzed amplification of STK15 gene in normal urothelium of 68 patients having undergone radical cystectomy for urothelial bladder carcinoma of the bladder at our department between 1998 and 2006 with available paraffin specimens.	Paraffin	231-239	aurora kinase A	Homo sapiens	45-50
24212133-5	2014	Immunohistochemical analysis for DR4 and DR5 was carried out on formalin-fixed paraffin-embedded sections of skin tissues using avidin-biotin peroxidase method.	Paraffin	79-87	TNF receptor superfamily member 10a	Homo sapiens	33-36
24240587-4	2013	MATERIALS AND METHODS: We conducted a systematic assessment of EphrinB1 expression in a set of 75 formalin-fixed paraffin-embedded breast cancers, using immunohistochemical staining (IHC) with a specific antibody, and we examined the relationship between EphrinB1 expression, histopathological parameters, and the expression of estrogen (ER), progesterone (PR), and HER-2 receptors.	Paraffin	113-121	ephrin B1	Homo sapiens	63-71
24925603-5	2014	COX-2 protein was detected by immunohistochemistry in formalin-fixed, paraffin wax-embedded lung tissues from 10 pigs infected experimentally with Mh.	Paraffin	70-82	cytochrome c oxidase subunit II	Sus scrofa	0-5
21423629-4	2011	Immunohistochemistry for CENP-A was performed on 80 paraffin-embedded HCC specimens, and the clinical significance of its expression was analyzed.	Paraffin	52-60	centromere protein A	Homo sapiens	25-31
22989649-4	2012	The paraffin removal test showed that the paraffin removal efficiencies of strain N2 and KB18 were 79.0% and 61.2%, respectively.	Paraffin	4-12	keratin 75	Homo sapiens	89-93
21167898-6	2011	Moreover, using immunohistochemistry on paraffin-embedded colonic tissue sections, we could show a co-localisation of DMBT1 and galectin 3 in human intestine, suggesting a potential physiological interaction.	Paraffin	40-48	galectin 3	Homo sapiens	128-138
21609571-2	2011	METHODS: EnVisiom immunohistochemical methods was used for determining the expressions of EphA7 and MTDH in routinely paraffin-embedded sections of surgically-resected specimens from 108 cases with gallbladder adenocarcinoma, 15 cases with adenomatous polyp and 35 cases with chronic cholecystitis treated from June 1996 to June 2006.	Paraffin	118-126	EPH receptor A7	Homo sapiens	90-95
24913732-7	2014	Secondly, we used branched DNA-liquidchip technology (bDNA-LCT) for detecting ASNS mRNA in formalin-fixed, paraffin-embedded tissue sections in 50 cases of NK/T cell lymphoma and in 12 cases of nasal polyps and chronic rhinitis.	Paraffin	107-115	asparagine synthetase (glutamine-hydrolyzing)	Homo sapiens	78-82
25013483-2	2014	The present study evaluated the mRNA expression of LRIG2 in tumor specimens obtained from 39 NSCLC patients by SYBR Green quantitative polymerase chain reaction and the protein expression of LRIG2 in formalin-fixed paraffin sections obtained from 116 NSCLC patients by immunohistochemistry.	Paraffin	215-223	leucine rich repeats and immunoglobulin like domains 2	Homo sapiens	191-196
22989649-4	2012	The paraffin removal test showed that the paraffin removal efficiencies of strain N2 and KB18 were 79.0% and 61.2%, respectively.	Paraffin	42-50	keratin 75	Homo sapiens	89-93
22842912-6	2012	Immunohistochemical analysis             revealed that 52 of 72 (72.2%) paraffin-embedded primary liver cancer tissues             displayed strong cytoplasmic staining of SMC4 protein, whereas only 6 (8.3%) normal             liver tissues showed immunostaining of SMC4.	Paraffin	72-80	structural maintenance of chromosomes 4	Homo sapiens	172-176
24947166-5	2014	Immunohistochemistry was performed to assess PTOV1 protein expression in 169 paraffin-embedded, archived breast cancer samples.	Paraffin	77-85	PTOV1 extended AT-hook containing adaptor protein	Homo sapiens	45-50
21107850-8	2011	The preponderance of SHH activity in adult MB tumours was also shown by positive SFRP1 immunostaining in 16/19 adult paraffin-embedded adult MB tumour blocks.	Paraffin	117-125	secreted frizzled related protein 1	Homo sapiens	81-86
22842912-6	2012	Immunohistochemical analysis             revealed that 52 of 72 (72.2%) paraffin-embedded primary liver cancer tissues             displayed strong cytoplasmic staining of SMC4 protein, whereas only 6 (8.3%) normal             liver tissues showed immunostaining of SMC4.	Paraffin	72-80	structural maintenance of chromosomes 4	Homo sapiens	266-270
24624358-0	2014	Pyrosequencing as a fast and reliable method in detecting the MYD88 p.L265P mutation in decalcified formalin-fixed and paraffin-embedded tissues.	Paraffin	119-127	MYD88 innate immune signal transduction adaptor	Homo sapiens	62-67
22855134-5	2012	Selected protein targets LGR4 and LGR6 were further validated on paraffin-embedded sections of ten intestinal and ten poorly cohesive (diffuse)-type GCs and their corresponding non-malignant tissue using immunohistochemistry.	Paraffin	65-73	leucine rich repeat containing G protein-coupled receptor 4	Homo sapiens	25-29
22820140-2	2011	We evaluated immunohistochemical expression of MMP-2 and TIMP-2 in paraffin sections of 12 human fetal thyroids at mid-term gestation and 79 thyroid tumors of follicular origin.	Paraffin	67-75	matrix metallopeptidase 2	Homo sapiens	47-52
21866462-2	2011	Since ER status is a prognostic and predictive factor in some cancers, we analysed the immunohistochemical expression of ERalpha and ERbeta in Reed-Sternberg (RS) cells in paraffin-embedded lymph node specimens from 27 children with classical Hodgkin lymphoma (HL) in relation to histological type, clinical stage, age, and gender.	Paraffin	172-180	estrogen receptor 2	Homo sapiens	133-139
22947189-7	2012	METHODS AND RESULTS: HLA-E expression was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections of 79 SCC, 38 ASC, and 75 AC patients.	Paraffin	94-102	major histocompatibility complex, class I, E	Homo sapiens	21-26
21183427-4	2010	The aim of this study was to determine the localization pattern of ASPP-2 in a variety of normal and malignant human tissues, including liver, lung, prostate, small intestine, kidney, ovary, bladder, cervix, breast, stomach, bowel, gallbladder, endometrium, pancreas, spleen and thyroid.The distribution and expression of ASPP-2 was assessed by immunohistochemistry in a range of formalin-fixed, paraffin embedded, benign and malignant human tissues, using a mouse monoclonal antibody against ASPP-2.The results showed a variable pattern of positivity of ASPP-2 within the tissues studied.	Paraffin	396-404	tumor protein p53 binding protein 2	Homo sapiens	67-73
20132196-4	2010	We performed immunohistochemical staining for NF-kappaB (p65) on paraffin-embedded sections of the tumour and corresponding normal tissues.	Paraffin	65-73	RELA proto-oncogene, NF-kB subunit	Homo sapiens	57-60
24366063-3	2014	In the current study, the expression of Galphao was analyzed by immunohistochemistry in paraffin-embedded tissue sections from 70 patients with GC and its cellular role was examined by small interfering RNA (siRNA)-mediated downregulation.	Paraffin	88-96	G protein subunit alpha o1	Homo sapiens	40-47
24257328-0	2014	Immunoelectron microscopic observation of chicken glucagon-like peptide (GLP)-1-containing cells in tissues derived from thin section, paraffin block and conventional method.	Paraffin	135-143	glucagon	Gallus gallus	50-79
20597554-0	2010	Citric acid antigen retrieval (CAAR) for tryptic peptide imaging directly on archived formalin-fixed paraffin-embedded tissue.	Paraffin	101-109	CTPL1	Homo sapiens	0-36
23691478-2	2012	METHODS: The level of CENP-H expression in the paraffin sections of 62 UCC cases was determined by the SP immunohistochemical method, with complete clinicopathologic data in all cases.	Paraffin	47-55	centromere protein H	Homo sapiens	22-28
19766362-3	2010	The expression of Id-1 protein was assessed in formalin-fixed, paraffin-embedded surgical specimens of ACCs by immunohistochemical staining.	Paraffin	63-71	inhibitor of DNA binding 1, HLH protein	Homo sapiens	18-22
23691478-4	2012	RESULTS: Immunohistochemical assay showed strong CENP-H expression in 61.29% (38/62) of the paraffin-embedded cervical cancer tissues.	Paraffin	92-100	centromere protein H	Homo sapiens	49-55
24105272-4	2014	The expression of SERPINB1 was evaluated using western blot analysis in 8 paired fresh HCC specimens and immunohistochemistrical assay on 67 paraffin-embedded HCC slices.	Paraffin	141-149	serpin family B member 1	Homo sapiens	18-26
22810971-5	2012	METHODS: CDH17 and CDX2 expressions in 182 paraffin-embedded EOC specimens were detected by immunohistochemical staining.	Paraffin	43-51	cadherin 17	Homo sapiens	9-14
24941742-7	2014	We also detected the expression of Bmp15 in oocyte at different development stages by immunofluorescence of fixed paraffin-embedded ovary sections.	Paraffin	114-122	bone morphogenetic protein 15	Cricetulus griseus	35-40
20421271-4	2010	DESIGN AND METHODS: Nuclear expression of CKS1B and p27(Kip1) was evaluated by immunohistochemistry in decalcified, paraffin-embedded bone marrow biopsies from 94 patients with newly diagnosed multiple myeloma.	Paraffin	116-124	CDC28 protein kinase regulatory subunit 1B	Homo sapiens	42-47
20700126-0	2010	In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues.	Paraffin	93-101	protein tyrosine kinase 6	Homo sapiens	31-56
20700126-0	2010	In situ quantification of HER2-protein tyrosine kinase 6 (PTK6) protein-protein complexes in paraffin sections from breast cancer tissues.	Paraffin	93-101	protein tyrosine kinase 6	Homo sapiens	58-62
22892044-0	2012	Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue.	Paraffin	180-188	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
19777244-4	2010	METHODS: A method with Western blotting and immunohistological staining for MMP-19 was performed using paraffin embedded human corneas.	Paraffin	103-111	matrix metallopeptidase 19	Homo sapiens	76-82
25081715-4	2014	MATERIALS AND METHODS: Immunohistochemistry was applied to evaluate TLR9 expression in 97 formalin-fixed paraffin-embedded cervical samples from Uyghur women; 32 diagnosed with cervical squamous cell carcinomas (CSCC) , 14 with low-grade cervical intraepithelial neoplasias (CINI), 10 medium-grade (CINII), 24 high-grade (CINIII), and 17 chronic cervicitis.	Paraffin	105-113	toll like receptor 9	Homo sapiens	68-72
22892044-0	2012	Nm23/nucleoside diphosphate kinase-A as a potent prognostic marker in invasive pancreatic ductal carcinoma identified by proteomic analysis of laser micro-dissected formalin-fixed paraffin-embedded tissue.	Paraffin	180-188	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	5-36
22970002-3	2012	Immunohistochemical analysis was performed to examine CXCR4 and CD133 protein expression in paraffin-embedded stage II or III primary colon cancer tissues and matched lymph nodes.	Paraffin	92-100	prominin 1	Homo sapiens	64-69
25124588-4	2014	The present study was undertaken to determine the level of TLR9 expression in cervical neoplasias from Tunisian women with 53 formalin-fixed and paraffin-embedded specimens, including 22 samples of invasive cervical carcinoma (ICC), 18 of cervical intraepithelial neoplasia (CIN), 7 of condyloma and 6 normal cervical tissues as control cases.	Paraffin	145-153	toll like receptor 9	Homo sapiens	59-63
20530450-2	2010	PATIENTS AND METHODS: Oestrogen and progesterone receptor expression was investigated by immunohistochemistry from paraffin-embedded tissue in 39 patients with adenocarcinoma of the uterine cervix.	Paraffin	115-123	progesterone receptor	Homo sapiens	36-57
20379448-3	2010	METHODS: Immunohistochemical staining of syndecan-1 was performed in 101 formalin fixed, paraffin embedded sections of normal, hyperplastic, and malignant endometrial tissues.	Paraffin	89-97	syndecan 1	Homo sapiens	41-51
22783425-3	2012	Immunohistochemical staining for Aur-A was performed on the paraffin sections of 208 patients with NPC.	Paraffin	60-68	aurora kinase A	Homo sapiens	33-38
20032008-7	2010	ERalpha, ERbeta, the coregulatory proteins SRC-1 and nuclear corepressor (NCoR), and the tyrosine kinase receptor HER2 were localised by immunohistochemistry and immnofluorescence in paraffin-embedded tissue from thyroid tumour patients (n=111).	Paraffin	183-191	nuclear receptor coactivator 1	Homo sapiens	43-48
25169552-4	2014	MATERIALS AND METHODS: The expression levels of miR-15a were analysed in BC formalin fixed paraffin embedded (FFPE) tissues by microarray and quantitative real-time PCR.	Paraffin	91-99	microRNA 15a	Homo sapiens	48-55
24132303-2	2013	Herein, we investigate the nature of olefin and paraffin binding on Fe/MOF-74 and identify several factors that determine separation efficiency using the first-principles calculations.	Paraffin	48-56	lysine acetyltransferase 8	Homo sapiens	71-74
24132303-6	2013	In particular, Fe/MOF-74 is shown to be a unique system where the guest-dependent magnetic transition observed only for the olefin adsorption is a secondary reason for the high olefin-paraffin adsorption selectivity measured.	Paraffin	184-192	lysine acetyltransferase 8	Homo sapiens	18-21
22515233-5	2012	In the organomicas with dodecylammonium, a transition from a parallel layer to a bilayer-paraffin arrangement is observed when the layer charge of the mica increases.	Paraffin	89-97	MHC class I polypeptide-related sequence A	Homo sapiens	13-17
23838921-6	2013	Immunohistochemical staining was used to determine the expression of GOLM1 in archived formalin-fixed, paraffin-embedded tissue specimens.	Paraffin	103-111	golgi membrane protein 1	Homo sapiens	69-74
23970101-4	2013	CENP-H protein levels were determined in 60 paired paraffin-embedded HCC tissues using immunohistochemistry (IHC), and the correlation with clinicopathological features and patient prognosis was analyzed.	Paraffin	51-59	centromere protein H	Homo sapiens	0-6
23970101-7	2013	In 60 paired paraffin-embedded tissues, CENP-H was upregulated in the HCC samples (38/60, 63.3%) relative to the adjacent non-cancerous samples (21/60, 35%, P=0.003), and a higher level of upregulation was associated with tumor size (P=0.032); higher histological grade (P=0.001); more advanced TNM stage (P=0.002) and Chinese clinical stage (P=0.008); and poorer prognosis.	Paraffin	13-21	centromere protein H	Homo sapiens	40-46
23981156-0	2013	PCR-based clonality analysis in diffuse large B-cell lymphoma using BIOMED-2 primers of IgH (FR3) on formalin-fixed paraffin-embedded tissue.	Paraffin	116-124	immunoglobulin heavy locus	Homo sapiens	88-91
23518907-5	2013	The expression of caspase-3 was assessed immunohistochemically in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	82-90	caspase 3	Rattus norvegicus	18-27
22747594-2	2013	The purpose of this study was to analyze SD-1 expression profile immunohistochemically in archival, paraffin-embedded tissue sections of ameloblastomas and in common odontogenic cysts arising from the same locale.	Paraffin	100-108	syndecan 1	Homo sapiens	41-45
23102595-3	2013	Pirh2 protein expression was assessed by immunohistochemical analysis in 92 paraffin-embedded specimens of human ccRCC and 30 specimens of adjacent normal renal tissue.	Paraffin	76-84	ring finger and CHY zinc finger domain containing 1	Homo sapiens	0-5
23995116-0	2013	MYD88 (L265P) Mutation in Malignant Lymphoma Using Formalin-Fixed Paraffin-Embedded Section.	Paraffin	66-74	MYD88 innate immune signal transduction adaptor	Homo sapiens	0-5
22642932-0	2012	Detection of JAK2 mutations in paraffin marrow biopsies by high resolution melting analysis: identification of L611S alone and in cis with V617F in polycythemia vera.	Paraffin	31-39	Janus kinase 2	Homo sapiens	13-17
22642932-8	2012	This indicates that these assays can detect known and novel JAK2 mutations in exons 12 and 14 using either fresh or paraffin-embedded archival materials.	Paraffin	116-124	Janus kinase 2	Homo sapiens	60-64
22147505-7	2012	Another 91 paraffin-embedded HCC tissues were examined by immunohistochemistry.	Paraffin	11-19	HCC	Homo sapiens	29-32
23252871-6	2012	Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion.	Paraffin	78-86	EWS RNA binding protein 1	Homo sapiens	119-124
23226728-3	2012	The expression of NEDD9 was analyzed by the SP method of immunohistochemistry for 60 formalin-fixed and paraffin-embedded (FFPE) lung adenocarcinoma tissues in which 32 cases were metastastic and 28 were without metastases.	Paraffin	104-112	neural precursor cell expressed, developmentally down-regulated 9	Homo sapiens	18-23
23050799-6	2012	Additionally, the proteins encoded by DEFA 1/3 and DEFA 4 were visualized in paraffin-embedded tissue sections by immunohistochemical staining.	Paraffin	77-85	defensin alpha 4	Homo sapiens	51-57
23031716-5	2012	The expression of B cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) was examined immunohistochemically on formalin-fixed paraffin-embedded primary tissue specimens.	Paraffin	144-152	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	84-89
22992310-3	2012	METHODS: We evaluated the expression of miR-34 in formalin-fixed paraffin-embedded (FFPE) human colon cancer tissue specimens compared to normal colonic mucosa.	Paraffin	65-73	microRNA 34a	Homo sapiens	40-46
23012488-7	2012	These results indicate that the two novel rat mAbs to the mouse and human/monkey podoplanin are useful for Western-blot and immunostaining of somatic tissues on paraffin-embedded sections as well as frozen sections.	Paraffin	161-169	podoplanin	Homo sapiens	81-91
22931894-5	2012	MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue.	Paraffin	54-62	major vault protein	Homo sapiens	0-3
22302483-8	2012	Immunofluorescence study on formalin-fixed, paraffin-embedded specimens confirmed the cytoplasmic expression of cathepsin D in cancer cells and non-tumor portions.	Paraffin	44-52	cathepsin D	Homo sapiens	112-123
22870594-2	2012	A study was conducted at the Department of Pathology, University of Malaya Medical Centre to determine the expression of CD133 in 56 archived, formalin-fixed, paraffin-embedded colorectal adenocarcinoma in comparison with adjacent benign colorectal epithelium by immunohistochemical staining for CD133 expression.	Paraffin	159-167	prominin 1	Homo sapiens	121-126
22179975-4	2012	The aim of the present study was to develop a method for the detection of chimeric PAX8-PPARG transcripts in formalin-fixed paraffin-embedded (FFPE) thyroid tumor samples by conventional RT-PCR.	Paraffin	124-132	paired box 8	Homo sapiens	83-87
22953501-2	2012	METHODS AND RESULTS: We used immunohistochemical techniques to evaluate monoclonal antibodies against CD2AP on over 400 formalin fixed paraffin embedded tissue blocks retrieved from the host institutions of three authors.	Paraffin	135-143	CD2 associated protein	Homo sapiens	102-107
22245045-6	2012	Furthermore, immunohistochemistry using paraffin-embedded tissues from 62 patients showed not only that the frequency of recurrence was correlated with the plectin expression but that the prognosis of patients with a high plectin was extremely poor.	Paraffin	40-48	plectin	Homo sapiens	156-163
22245045-6	2012	Furthermore, immunohistochemistry using paraffin-embedded tissues from 62 patients showed not only that the frequency of recurrence was correlated with the plectin expression but that the prognosis of patients with a high plectin was extremely poor.	Paraffin	40-48	plectin	Homo sapiens	222-229
22415220-0	2012	Immunohistochemical detection of glypican-5 in paraffin-embedded material: an optimized method for a novel research antibody.	Paraffin	47-55	glypican 5	Homo sapiens	33-43
21982044-4	2012	Expression of B7-H3 in endometrial hyperplasia, endometrial carcinoma, and the endothelium of tumor-associated vasculature was assessed using immunohistochemistry from paraffin-embedded tissue blocks.	Paraffin	168-176	CD276 molecule	Homo sapiens	14-19
21644819-7	2012	We describe a detailed method for immunostaining MMP-9 in mouse lung paraffin-embedded tissue utilizing human ovary as a control since MMP-9 is known to be over-expressed in human ovarian carcinomas.	Paraffin	69-77	matrix metallopeptidase 9	Mus musculus	49-54
20224723-3	2010	To further assess the clinical and biological significance of GSK-3beta inactivation in MCL, we employed immunohistochemistry to assess the expression of the phosphorylated/inactive form of GSK-3beta (pGSK-3beta) in 83 paraffin-embedded tumors, and correlated its expression with various biological and clinical parameters.	Paraffin	219-227	glycogen synthase kinase 3 beta	Homo sapiens	190-199
19741063-5	2010	Additionally, the SP-A expression pattern was evaluated by immunohistochemistry in formalin-fixed, paraffin-embedded lung tissue sections from the same subjects.	Paraffin	99-107	surfactant protein A1	Homo sapiens	18-22
20019769-2	2009	METHODS: Expression of co-stimulator CD86 and ICOS was examined by immunohistochemistry on paraffin embedded tissue from patients with CD (30 cases) and normal controls (20 cases).	Paraffin	91-99	CD86 molecule	Homo sapiens	37-41
19516275-4	2009	We then outline how a highly specific immunohistochemical assay can be exploited to diagnose NPM1-mutated AML and myeloid sarcoma in paraffin-embedded samples by looking at aberrant nucleophosmin accumulation in cytoplasm of leukaemic cells.	Paraffin	133-141	nucleophosmin 1	Homo sapiens	93-97
19820381-6	2009	Reverse transcriptase polymerase chain reaction analysis from paraffin-embedded tissue revealed EWS-FLI1 fusion product in 1 case.	Paraffin	62-70	EWS RNA binding protein 1	Homo sapiens	96-99
19332433-4	2009	The aim of the present retrospective study was to determine the expression of galectin-3 immunoperoxidase in laryngeal carcinoma by examining paraffin-embedded larynx biopsies from 65 patients, 10 in situ laryngeal carcinomas, 27 laryngeal carcinomas without metastases, and 28 with metastases.	Paraffin	142-150	galectin 3	Homo sapiens	78-88
19500341-5	2009	CENP-H protein level in paraffin-embedded tongue cancer tissues were tested by immunohistochemical staining and undergone statistical analysis.	Paraffin	24-32	centromere protein H	Homo sapiens	0-6
19500341-9	2009	It was overexpressed in 55.95% (94/168) of the paraffin-embedded tongue cancer tissues, and there was a strong correlation between CENP-H expression and clinical stage, as well as T classification.	Paraffin	47-55	centromere protein H	Homo sapiens	131-137
19401687-4	2009	Immunohistochemical staining of paraffin-embedded tissues showed that hnRNP K was overexpressed in PCa, where it was localised both in the cytoplasm and in the nucleus.	Paraffin	32-40	heterogeneous nuclear ribonucleoprotein K	Homo sapiens	70-77
19232520-8	2009	By immunohistochemical analysis, we found that paraffin-embedded archival HCC tissues showed higher expression of STK15 than adjacent tumors and normal liver tissues.	Paraffin	47-55	aurora kinase A	Homo sapiens	114-119
19509563-4	2009	miR-29b expression was analyzed using quantitative stem-loop reverse transcriptase polymerase chain reaction on a set of 50 formalin-fixed, paraffin-embedded ovarian serous carcinoma samples.	Paraffin	140-148	microRNA 29b-1	Homo sapiens	0-7
19492023-2	2009	In this study, we optimized the protocol conditions for the detection of X chromosome-linked phosphoglycerate kinase-1 (pgk-1) gene in paraffin-embedded sections of mouse reproductive organs.	Paraffin	135-143	phosphoglycerate kinase 1	Mus musculus	93-118
19492023-2	2009	In this study, we optimized the protocol conditions for the detection of X chromosome-linked phosphoglycerate kinase-1 (pgk-1) gene in paraffin-embedded sections of mouse reproductive organs.	Paraffin	135-143	phosphoglycerate kinase 1	Mus musculus	120-125
19052772-0	2009	Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver.	Paraffin	129-137	vinculin	Homo sapiens	0-8
19052772-0	2009	Vinculin and cellular retinol-binding protein-1 are markers for quiescent and activated hepatic stellate cells in formalin-fixed paraffin embedded human liver.	Paraffin	129-137	retinol binding protein 1	Homo sapiens	13-47
19032384-4	2009	Immunohistochemical (IHC) expression of PAR-2 was examined using paraffin-embedded sections from 30 BCCs, 30 SCCs and also 30 normal sun-exposed skin specimens.	Paraffin	65-73	F2R like trypsin receptor 1	Homo sapiens	40-45
19148512-4	2009	Mucin histochemistry by paradoxical concanavalin A (Con A) staining and immunostaining for 45M1, MUC2 glycoprotein and CD10 of mucin was performed in surgically obtained paraffin-embedded specimens from 106 gastric adenocarcinomas.	Paraffin	170-178	LOC100508689	Homo sapiens	0-5
18720326-7	2008	The positive detection of the SYT-SSX1 fusion transcripts with reverse-transcription polymerase chain reaction in formalin-fixed and paraffin-embedded tissue confirmed the synovial sarcoma diagnosis.	Paraffin	133-141	synaptotagmin 1	Homo sapiens	30-33
18695901-2	2008	The expression of CAIX and VEGF was evaluated immunohistochemically in 122 paraffin-embedded ccRCC specimens.	Paraffin	75-83	carbonic anhydrase 9	Homo sapiens	18-22
18751416-4	2008	PATIENTS AND METHODS: The production of CCN2 was explored by using immunohistochemistry on paraffin-embedded tissues from 20 cases of mandibular squamous cell carcinoma.	Paraffin	91-99	cellular communication network factor 2	Homo sapiens	40-44
18300804-12	2008	Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).	Paraffin	89-97	EWS RNA binding protein 1	Homo sapiens	147-152
18300804-12	2008	Reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues demonstrated transcripts of the EWSR1-ATF1 (31/33) or EWSR1-CREB1 fusion gene (2/33).	Paraffin	89-97	EWS RNA binding protein 1	Homo sapiens	169-174
18245522-10	2008	RESULTS: We showed CCR9 expression in 88 of 102 paraffin-embedded metastatic melanomas from the small intestine, 8 of 8 melanoma lines derived from metastases in the small intestine, and 0 of 96 metastatic melanomas from other sites.	Paraffin	48-56	C-C motif chemokine receptor 9	Homo sapiens	19-23
18231910-4	2008	The pattern of FOXP3 protein expression was evaluated using standard immunohistochemistry in paraffin-embedded tissue samples.	Paraffin	93-101	forkhead box P3	Homo sapiens	15-20
18210110-7	2008	Molecular analysis of AAT and HFE genes in paraffin-embedded tissue or blood can confirm the diagnosis and allows the zygosity status to be defined.	Paraffin	43-51	homeostatic iron regulator	Homo sapiens	30-33
18333330-12	2008	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX 1 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Paraffin	117-125	synaptotagmin 1	Homo sapiens	152-155
17936340-5	2008	METHODS: Immunohistochemistry was used to analyze PAR-2 expression in fixed paraffin-embedded tumor tissue from 16 patients with invasive cervical cancer.	Paraffin	76-84	F2R like trypsin receptor 1	Homo sapiens	50-55
17706406-9	2007	CONCLUSIONS: The distribution of CA IX expression in paraffin-embedded tissue sections seen in this series is consistent with previous studies in bladder cancer, but does not provide significant prognostic information with respect to the response to radiotherapy at 3 months and disease-specific survival after radical radiotherapy.	Paraffin	53-61	carbonic anhydrase 9	Homo sapiens	33-38
18001421-5	2007	METHODS: We studied immunohistochemical expression of CD1a on paraffin-embedded tissue in 12 cases of SCC and 11 cases of PEH of the skin.	Paraffin	62-70	CD1a molecule	Homo sapiens	54-58
17940995-5	2007	S100A2 expression in 14 pancreatic cancer cell lines, microdissected cells and formalin-fixed paraffin-embedded (FFPE) samples was examined by quantitative reverse transcription-polymerase chain reaction (qRT-PCR).	Paraffin	94-102	S100 calcium binding protein A2	Homo sapiens	0-6
17440926-4	2007	TLR9 expression was evaluated by immunohistochemistry in 55 formalin-fixed paraffin-embedded cervical tissues; nine normal cervical specimens, 10 low-grade cervical intraepithelial neoplasias (CINs), 12 high-grade CINs, and 24 invasive squamous cell carcinomas (ISCCs).	Paraffin	75-83	toll like receptor 9	Homo sapiens	0-4
17850769-7	2007	Ketamine-induced Tnnt1 expression was confirmed and characterized using RNA in situ hybridization techniques in paraffin embedded brain tissue sections.	Paraffin	112-120	troponin T1, skeletal, slow	Mus musculus	17-22
21880371-0	2012	Molecular cytogenetic interphase analysis of Phosphoinositide-specific Phospholipase C beta1 gene in paraffin-embedded brain samples of major depression patients.	Paraffin	101-109	phospholipase C beta 1	Homo sapiens	45-86
21880371-3	2012	By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 gene, which codifies for the PI-PLC beta1 enzyme, in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with major depression and in 15 normal controls.	Paraffin	138-146	phospholipase C beta 1	Homo sapiens	79-84
21880371-3	2012	By using interphase fluorescent in situ hybridization methodology, we analyzed PLCB1 gene, which codifies for the PI-PLC beta1 enzyme, in paraffin embedded samples of orbito-frontal cortex of 15 patients affected with major depression and in 15 normal controls.	Paraffin	138-146	phospholipase C beta 1	Homo sapiens	114-120
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Paraffin	52-60	erb-b2 receptor tyrosine kinase 3	Homo sapiens	131-135
17711507-1	2007	A monoclonal antibody (mAb) MY.1E12 was applied to detect MUC1 with sialylated glycans in a total of 55 formalin-fixed, paraffin-embedded surgical specimens of ovarian clear cell adenocarcinomas.	Paraffin	120-128	mucin 1, cell surface associated	Homo sapiens	58-62
22969936-4	2012	PRLR expression was analyzed in 48 paraffin-embedded tissues (18 RRP and 30 laryngeal cancer tissues) by immunoperoxidase staining.	Paraffin	35-43	prolactin receptor	Homo sapiens	0-4
17786718-0	2007	A limited number of IgH-primers binding to framework region 1 is sufficient to detect the majority of mature small B-cell non-Hodgkin lymphomas on formalin-fixed paraffin-embedded tissue by PCR.	Paraffin	162-170	immunoglobulin heavy locus	Homo sapiens	20-23
17786718-1	2007	IGH gene rearrangement analysis by PCR is the widely accepted tool to determine clonality of B-cell lymphoid proliferations on formalin-fixed, paraffin-embedded tissue, but the results are often unsatisfying in terms of sensitivity.	Paraffin	143-151	immunoglobulin heavy locus	Homo sapiens	0-3
21815153-2	2012	METHODS: EnVision immunohistochemical method for determining the expressions of MUC1 and MUC5AC was used in routinely paraffin-embedded sections of surgically resected specimens from gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenoma (n = 15), and chronic cholecystitis (n = 35).	Paraffin	118-126	mucin 1, cell surface associated	Homo sapiens	80-84
21960059-9	2012	High expression of miR34a can be detected also in paraffin-embedded tissues by in situ hybridization, thus contributing to an easy routine evaluation of this miRNA.	Paraffin	50-58	microRNA 34a	Homo sapiens	19-25
24213134-9	2011	To the best of our knowledge, this is the first published report evaluating the implications of increased IHC expression of CENPA in paraffin embedded breast tissue samples.	Paraffin	133-141	centromere protein A	Homo sapiens	124-129
17882793-0	2007	[Monoclonal analysis of immunoglobulin heavy chain and T-cell receptor gamma chain gene rearrangements in paraffin-embedded tissues from non-Hodgkin lymphoma patients].	Paraffin	106-114	immunoglobulin heavy constant delta	Homo sapiens	24-50
22385677-7	2012	Immunohistochemical analysis demonstrated a high expression of SOX9 in 74/142 (52.1%) paraffin-embedded archival lung cancer biopsies.	Paraffin	86-94	SRY-box transcription factor 9	Homo sapiens	63-67
17845763-3	2007	RT-PCR Detection of the SYT-SSX fusion gene was performed using paraffin embedded tissue samples.	Paraffin	64-72	synaptotagmin 1	Homo sapiens	24-27
17845767-0	2007	[Detection of t (11; 18) and rearrangement of bcl-10 in paraffin-embedded samples using interphase fluorescence in-situ hybridization].	Paraffin	56-64	BCL10 immune signaling adaptor	Homo sapiens	46-52
17368732-4	2007	RESULTS: The expression of MUC1 was found in 92% (39/42) of EOC and 90% (27/30) of the matched metastatic lesions in frozen tissue sections respectively while the expression of MUC1 was found in 95% (57/60) of EOC and 5% (1/20) of normal ovarian tissues in paraffin-embedded sections respectively.	Paraffin	257-265	mucin 1, cell surface associated	Homo sapiens	27-31
17543078-0	2007	Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.	Paraffin	45-53	transcription factor binding to IGHM enhancer 3	Homo sapiens	25-29
17892132-2	2007	METHODS: (1) The levels of AT1R mRNA were examined by quantitative reverse transcriptase-polymerase chain reaction( RT-PCR) in paraffin-embedded tissues from 35 cases of cervical squamous cell carcinoma, 15 cases of cervical intraepithelial neoplasia (CIN), and 15 cases of normal cervix, and in Siha and C33a cells.	Paraffin	127-135	angiotensin II receptor type 1	Homo sapiens	27-31
17873329-7	2007	In samples of archived paraffin-embedded endometrial tissue TrkB was localized to the cytoplasm of epithelial cells of the eutopic endometrium from women with endometriosis (n = 7) and without endometriosis (n = 10).	Paraffin	23-31	neurotrophic receptor tyrosine kinase 2	Homo sapiens	60-64
17471153-9	2007	Our results suggest that BT-based ISH can be used as a molecular technique for the detection of SS18-SSX using formalin-fixed, paraffin-embedded tissues.	Paraffin	127-135	SSX family member 2	Homo sapiens	101-104
17143956-2	2006	METHODS: Rabbit-anti-FHIT antibody was used to detect FHIT protein expression in 64 formalin-fixed, paraffin-embedded tissue specimens of inflammatory bowel disease (IBD) by citrate-microwave-streptavidin (SP)-HRP immunohistochemical method.	Paraffin	100-108	fragile histidine triad diadenosine triphosphatase	Homo sapiens	54-58
17153776-0	2006	Detection of the t(11;18) API2/MALT1 translocation associated with gastric MALT lymphoma in routine formalin-fixed, paraffin-embedded small endoscopic biopsy specimens by robust real-time RT-PCR.	Paraffin	116-124	MALT1 paracaspase	Homo sapiens	31-36
17259097-2	2006	METHODS: SP immunohistochemistry was used to detect the expression of galectin-3 in 158 cases of paraffin-embedded specimens (including 30 normal mucosa, 25 adenoma, 65 carcinoma and 38 metastatic tumor specimens).	Paraffin	97-105	galectin 3	Homo sapiens	70-80
16949936-3	2006	In this study, detection of expression of syndecan-1 protein and Epstein-Barr virus-encoded latent membrane protein-1 (LMP-1) in primary, recurrent, and metastatic NPC specimens in paraffin sections was performed by immunohistochemistry.	Paraffin	181-189	syndecan 1	Homo sapiens	42-52
17023741-3	2006	We assayed expression of Smad4 in OSCC and normal oral mucosa by performing immunohistochemistry using paraffin-embedded tissue samples.	Paraffin	103-111	SMAD family member 4	Homo sapiens	25-30
16886681-4	2006	MATERIALS AND METHODS: The expression of CLU was studied immunohistochemically in paraffin sections of primary cutaneous malignant melanomas, metastases of malignant melanomas and acquired melanocytic naevi.	Paraffin	82-90	clusterin	Homo sapiens	41-44
16670177-8	2006	In paraffin-embedded brain tissue samples of two affected siblings of the Pakistani patient, cathepsin D was absent, suggesting rapid degradation of the c.764dupA mutant cathepsin D at mRNA or protein level in vivo.	Paraffin	3-11	cathepsin D	Homo sapiens	170-181
16800931-1	2006	To evaluate the expression of P120ctn in non-Hodgkin"s lymphoma (NHL) and to explore its clinical significance, immunohistochemistry stain method was applied to comparatively investigate the protein expression of P120ctn in paraffin-embedded lymph node tissue slices from 40 cases of NHL and 10 cases of reactive hyperplasia of lymph node.	Paraffin	224-232	catenin delta 1	Homo sapiens	30-37
16800931-1	2006	To evaluate the expression of P120ctn in non-Hodgkin"s lymphoma (NHL) and to explore its clinical significance, immunohistochemistry stain method was applied to comparatively investigate the protein expression of P120ctn in paraffin-embedded lymph node tissue slices from 40 cases of NHL and 10 cases of reactive hyperplasia of lymph node.	Paraffin	224-232	catenin delta 1	Homo sapiens	213-220
16700664-5	2006	Anti-CXCR3 staining is a useful marker for human cutaneous and mucosal MC in paraffin-embedded sections.	Paraffin	77-85	C-X-C motif chemokine receptor 3	Homo sapiens	5-10
16594742-12	2006	For practical purposes, CD31 may be used as an immunohistochemical marker for distinguishing between white and brown fat and for diagnosing hibernoma in paraffin sections.	Paraffin	153-161	platelet and endothelial cell adhesion molecule 1	Homo sapiens	24-28
16495697-5	2006	METHODS: We evaluated the immunohistochemical expression of CA IX and VEGF on paraffin-embedded material of 154 resection specimens: 39 esophageal, 73 cardiac, and 42 distal gastric adenocarcinomas (UICC classification).	Paraffin	78-86	carbonic anhydrase 9	Homo sapiens	60-65
16430470-2	2006	METHOD AND RESULTS: A polyclonal antibody to the C terminus of CD19 was used to immunostain paraffin-embedded samples of normal and neoplastic lymphoid tissues.	Paraffin	92-100	CD19 molecule	Homo sapiens	63-67
16543737-0	2006	Development of a novel method to detect Helicobacter pylori cagA genotype from paraffin-embedded materials: comparison between patients with duodenal ulcer and gastric cancer in young Japanese.	Paraffin	79-87	S100 calcium binding protein A8	Homo sapiens	60-64
16543737-2	2006	We investigated the implication of the cagA polymorphism in young Japanese patients using paraffin-embedded sections.	Paraffin	90-98	S100 calcium binding protein A8	Homo sapiens	39-43
16543737-7	2006	RESULTS: We established a novel method to determine the cagA subtype using paraffin-embedded sections.	Paraffin	75-83	S100 calcium binding protein A8	Homo sapiens	56-60
16543737-10	2006	CONCLUSIONS: cagA polymorphism can be evaluated with the use of paraffin-embedded sections.	Paraffin	64-72	S100 calcium binding protein A8	Homo sapiens	13-17
16354354-2	2005	An immunohistochemical technique was employed for detection of PGR- and EGR-specific immunoreactivity in MECh samples using formalin-fixed paraffin-embedded tissue sections.	Paraffin	139-147	progesterone receptor	Homo sapiens	63-66
16224211-3	2005	Recently, antibodies directed against M2A (D2-40), Podoplanin, and Prox-1 that specifically mark lymphatic vessels in paraffin-embedded sections have become available.	Paraffin	118-126	prospero homeobox 1	Homo sapiens	67-73
16210018-7	2005	MAIN OUTCOME MEASURE(S): Matrix metalloproteinase 1, ERalpha, and ERbeta protein expression in paraffin-embedded tissue biopsies was measured by IHC.	Paraffin	95-103	estrogen receptor 2	Homo sapiens	66-72
15782116-3	2005	In addition, we used a sensitive RT-PCR strategy to define the expression of SEPT9 isoforms in archival formalin-fixed and paraffin-embedded normal human tissues.	Paraffin	123-131	septin 9	Homo sapiens	77-82
15861408-7	2005	Additionally, among the extracellular matrix proteins analyzed, expression of fibronectin was elevated in the RXRalpha-/- as assessed by immunostaining in paraffin-embedded sections and proepicardial explants.	Paraffin	155-163	retinoid X receptor alpha	Mus musculus	110-118
15613866-6	2005	Moreover, fluorescence in situ hybridization performed on paraffin-embedded tissue sections demonstrated an immunoglobulin heavy chain (IGH)/BCL2 translocation signal in both follicular and diffuse components, but an IGH/c-MYC translocation signal in only the diffuse component.	Paraffin	58-66	immunoglobulin heavy constant delta	Homo sapiens	108-134
15613866-6	2005	Moreover, fluorescence in situ hybridization performed on paraffin-embedded tissue sections demonstrated an immunoglobulin heavy chain (IGH)/BCL2 translocation signal in both follicular and diffuse components, but an IGH/c-MYC translocation signal in only the diffuse component.	Paraffin	58-66	immunoglobulin heavy constant delta	Homo sapiens	136-139
15665281-6	2005	Immunostaining of myelin basic protein on paraffin sections derived from 18 incompletely resected JPAs suggests that JPA without myelin basic protein-positively stained tumor cells may have a higher tendency to progress.	Paraffin	42-50	myelin basic protein	Homo sapiens	18-38
16308102-4	2005	Here, we describe a double-immunostaining strategy for formalin-fixed, paraffin-embedded tissues that aims at evaluating the distribution of Prox-1 and CD 31 - a cytoplasmic pan-endothelial marker - in a series of 28 mucousae, cutaneous and soft tissue vascular lesions and tumors, including hemangiomas, lymphangiomas, lymphangiectasia, and Kaposi"s sarcomas.	Paraffin	71-79	prospero homeobox 1	Homo sapiens	141-147
16308102-4	2005	Here, we describe a double-immunostaining strategy for formalin-fixed, paraffin-embedded tissues that aims at evaluating the distribution of Prox-1 and CD 31 - a cytoplasmic pan-endothelial marker - in a series of 28 mucousae, cutaneous and soft tissue vascular lesions and tumors, including hemangiomas, lymphangiomas, lymphangiectasia, and Kaposi"s sarcomas.	Paraffin	71-79	platelet and endothelial cell adhesion molecule 1	Homo sapiens	152-157
15623599-8	2004	This is the first localization of all of the VIP/PACAP receptor subtypes in human formalin-fixed, paraffin-embedded tissues.	Paraffin	98-106	adenylate cyclase activating polypeptide 1	Homo sapiens	49-54
15470680-10	2004	Investigation of the relationship between E2F6 and RING1 by immunofluorescence and confocal analysis, in HL cell lines and paraffin sections, revealed co-expression of both proteins in the same tumour cells.	Paraffin	123-131	E2F transcription factor 6	Homo sapiens	42-46
15598229-2	2004	Paraffin sections of ovary were immunostained with mouse monoclonal antibody to proliferating cell nuclear antigen (PCNA).	Paraffin	0-8	proliferating cell nuclear antigen	Bos taurus	80-114
15598229-2	2004	Paraffin sections of ovary were immunostained with mouse monoclonal antibody to proliferating cell nuclear antigen (PCNA).	Paraffin	0-8	proliferating cell nuclear antigen	Bos taurus	116-120
15582534-6	2004	The monoclonal Ab can be used to detect AKR1C3 expression by immunohistochemistry in sections of paraffin-embedded mammary gland and prostate.	Paraffin	97-105	aldo-keto reductase family 1 member C3	Homo sapiens	40-46
15565546-0	2004	Identification of various exon combinations of the ews/fli1 translocation: an optimized RT-PCR method for paraffin embedded tissue -- a report by the CWS-study group.	Paraffin	106-114	EWS RNA binding protein 1	Homo sapiens	51-54
22024187-8	2011	MATERIALS AND METHODS: We used the immunochemistry method to investigate the expression of galectin-3 and cyclin D1 in the paraffin-embedded tumor tissue of 47 patients (32 men and 15 women; mean age 59.34 +- 8.90).	Paraffin	123-131	galectin 3	Homo sapiens	91-101
21752896-12	2011	CONCLUSIONS: Our results demonstrate that SDHA immunohistochemistry on paraffin-embedded tumors can reveal the presence of SDHA germline mutations and allowed the identification of SDHA-related tumors in at least 3% of patients affected by apparently sporadic (para)sympathetic paragangliomas and pheochromocytomas.	Paraffin	71-79	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	42-46
21752896-12	2011	CONCLUSIONS: Our results demonstrate that SDHA immunohistochemistry on paraffin-embedded tumors can reveal the presence of SDHA germline mutations and allowed the identification of SDHA-related tumors in at least 3% of patients affected by apparently sporadic (para)sympathetic paragangliomas and pheochromocytomas.	Paraffin	71-79	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	123-127
21752896-12	2011	CONCLUSIONS: Our results demonstrate that SDHA immunohistochemistry on paraffin-embedded tumors can reveal the presence of SDHA germline mutations and allowed the identification of SDHA-related tumors in at least 3% of patients affected by apparently sporadic (para)sympathetic paragangliomas and pheochromocytomas.	Paraffin	71-79	succinate dehydrogenase complex flavoprotein subunit A	Homo sapiens	123-127
21185830-3	2011	Fluorescent in situ hybridization analysis performed on paraffin-embedded tissue sections of primary tumor sample indicated one rearranged locus of EWSR1 gene and one additional red signal.	Paraffin	56-64	EWS RNA binding protein 1	Homo sapiens	148-153
21225230-7	2011	We also detected 12-LOX overexpression in PCa SCs in human PCa tissue samples by paraffin-section based immunofluorescent 4-channel confocal microscopy.	Paraffin	81-89	arachidonate 12-lipoxygenase, 12S type	Homo sapiens	17-23
21279521-12	2011	We conclude that immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts in formalin-fixed, paraffin-embedded tissues are powerful tools in the diagnosis of ASPS, particularly in cases with unusual morphologic features.	Paraffin	125-133	transcription factor binding to IGHM enhancer 3	Homo sapiens	82-86
21674866-2	2011	The aim of this research was to reveal sporadic, postzygous RB1 gene mutations, in particular loss of heterozygosity (LOH), from formalin-fixed, paraffin-embedded tumor samples in RB patients, as well as tracking RB1 allele inheritance in 10 RB families.	Paraffin	145-153	RB transcriptional corepressor 1	Homo sapiens	60-63
21391734-4	2011	We evaluated CD40 expression in formalin-fixed, paraffin-embedded samples from 181 breast carcinomas using immunohistochemical staining with CD40 antibody.	Paraffin	48-56	CD40 molecule	Homo sapiens	13-17
21088377-3	2011	MATERIALS AND METHODS: Immunohistochemical CLU expression was investigated in paraffin-embedded archival tissues of initial transurethral resection specimens of 46 patients with non-muscle-invasive bladder carcinoma.	Paraffin	78-86	clusterin	Homo sapiens	43-46
15565546-26	2004	CONCLUSIONS: Using our different sets of exon specific primer pairs, it was possible to detect 4 different breakpoints of ews/fli1 fusion transcripts and the ews/erg fusion by RT-PCR in RNA isolates from formalin-fixed, paraffin-embedded Ewing"s tumor tissue.	Paraffin	220-228	EWS RNA binding protein 1	Homo sapiens	122-125
15487888-3	2004	We used immunohistochemistry (IHC) to investigate SCP-1 expression in paraffin-fixed EOC samples and ELISA to test sera from a subgroup of patients for SCP-1 antibody.	Paraffin	70-78	synaptonemal complex protein 1	Homo sapiens	50-55
21912076-4	2012	A peptide antibody against AMTN was raised in rabbits, affinity purified and used for immunohistochemical analyses on sagittal and transverse paraffin sections of decalcified mouse hemimandibles.	Paraffin	142-150	amelotin	Oryctolagus cuniculus	27-31
15447686-1	2004	Stereological methods were used to quantify secretin and gastric inhibitory peptide (GIP)-immunoreactivity (GIP-IR) in paraffin sections of the duodenum, jejunum and ileum of fetal and neonatal piglets.	Paraffin	119-127	GIP	Sus scrofa	85-88
15447686-1	2004	Stereological methods were used to quantify secretin and gastric inhibitory peptide (GIP)-immunoreactivity (GIP-IR) in paraffin sections of the duodenum, jejunum and ileum of fetal and neonatal piglets.	Paraffin	119-127	GIP	Sus scrofa	108-111
22049223-4	2012	METHODS: The CRBP1 gene methylation promoter was assessed by methylation specific PCR analysis in tissue samples from larynx cancer specimens and its expression was assessed by immunohistochemistry on paraffin embedded tissue using tissue microarray.	Paraffin	201-209	retinol binding protein 1	Homo sapiens	13-18
15363040-10	2004	Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue.	Paraffin	139-147	MALT1 paracaspase	Homo sapiens	19-24
15300917-5	2004	Fluorescence in situ hybridization on paraffin-embedded tissue sections (T-FISH) identified a translocation of BCL2 with IGH gene.	Paraffin	38-46	immunoglobulin heavy locus	Homo sapiens	121-124
20001967-5	2010	RGS2 protein was detected by immunostaining in 118 paraffin-embedded specimens, and the correlations between clinicopathological factors and survival time and RGS2 expression were analysed.	Paraffin	51-59	regulator of G protein signaling 2	Homo sapiens	0-4
22349375-5	2012	Immunohistochemistry and statistics were used to evaluate the correlation of nm23-H1 expression with clinicopathological features and clinical outcomes in paraffin-embedded archival tissues including 93 cases of primary NPC and 20 cases of cervical lymphonode metastatic NPC (LMNPC).	Paraffin	155-163	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	77-84
21086718-6	2010	TLR9 expression was examined in the dermis and epidermis by immunohistochemical analysis of paraffin-embedded biopsy tissue.	Paraffin	92-100	toll like receptor 9	Homo sapiens	0-4
19806481-4	2010	We analyzed the expression of cyclinD1 and p16 antigens in a series of 42 MB with various grades and pathological types by immunohistochemical analysis on paraffin-embedded sections.	Paraffin	155-163	cyclin D1	Homo sapiens	30-38
15280411-7	2004	CRBP1 expression was assessed by immunohistochemistry on formalin fixed, paraffin wax embedded tissue.	Paraffin	73-85	retinol binding protein 1	Homo sapiens	0-5
15563089-3	2004	The expression of MMP14 protein in paraffin-embedded tissues was determined immunohistochemically.	Paraffin	35-43	matrix metallopeptidase 14	Homo sapiens	18-23
22246354-2	2011	METHODS: Envision immunohistochemistry was used to assay the expression levels of EphA7 and MTDH in the conventional paraffin-embedded sections from specimens of squamous cell cancer (n=45) and peritumoral normal tissues (n=10).	Paraffin	117-125	EPH receptor A7	Homo sapiens	82-87
21710496-5	2011	One of these reagents, recognizing an epitope located at the COOH terminus of the MAGE-A10 gene product, was used to stain a multitumor tissue microarray comprising more than 2,500 paraffin-embedded specimens including healthy tissues, benign tumors and malignancies of different histological origin.	Paraffin	181-189	MAGE family member A10	Homo sapiens	82-90
15122585-6	2004	When tumor cells retrieved from paraffin-embedded tissue were examined by flow cytometry, higher proportions of cells expressing only cdk4 or cyclin D1 in type A cases and of cells expressing any cyclin or cdk in type B cases showed a subdiploid DNA content.	Paraffin	32-40	cyclin dependent kinase 4	Homo sapiens	134-138
15239399-5	2004	Results of immunohistochemical analysis of paraffin-embedded specimens were positive for cyclin D1 and Bcl2 in the tumor cells.	Paraffin	43-51	cyclin D1	Homo sapiens	89-98
20714875-3	2010	The expression of AT1R and AT2R proteins in paraffin-embedded slices of tissue was detected by immunohistochemistry.	Paraffin	44-52	angiotensin II receptor type 1	Homo sapiens	18-22
20714875-3	2010	The expression of AT1R and AT2R proteins in paraffin-embedded slices of tissue was detected by immunohistochemistry.	Paraffin	44-52	angiotensin II receptor type 2	Homo sapiens	27-31
21887928-9	2011	Paraffin embedded tissues represent a valuable source of DNA which can be used in the diagnostics of both JAK2 exon 12 and exon 14 mutations.	Paraffin	0-8	Janus kinase 2	Homo sapiens	106-110
21317913-4	2011	The expression of syndecan-1 and -2 was examined by immunohistochemical staining in a series of 60 paraffin-embedded tissue samples from patients with localized prostate cancer.	Paraffin	99-107	syndecan 1	Homo sapiens	18-35
20591216-3	2010	METHODS: Tissue microarray and immunohistochemical staining were performed to detect PAK1 in paraffin specimens of 189 gastric carcinomas, 54 paracancer tissues, 40 lymph nodes and 30 healthy tissues.	Paraffin	93-101	p21 (RAC1) activated kinase 1	Homo sapiens	85-89
20514415-5	2010	CA9 expression was examined in paraffin-embedded sections by immunohistochemistry.	Paraffin	31-39	carbonic anhydrase 9	Homo sapiens	0-3
15256115-1	2004	OBJECTIVE: To investigate the feasibility of detecting API2-MALT1 fusion gene transcript in paraffin-embedded tissue and its diagnostic value for pulmonary MALT lymphoma.	Paraffin	92-100	MALT1 paracaspase	Homo sapiens	60-65
15256115-9	2004	CONCLUSION: Detection of API2-MALT1 fusion transcript in paraffin-embedded tissues is feasible by nested RT-PCR and is of diagnostic value.	Paraffin	57-65	MALT1 paracaspase	Homo sapiens	30-35
15338868-2	2004	METHODS: Immunohistochemistry staining (PicTure two steps method) was used to detect connexin 43 and E-cadherin expression in 60 paraffin-embedded laryngeal carcinomas and 10 normal epithelia around tumors.	Paraffin	129-137	gap junction protein alpha 1	Homo sapiens	85-96
21383546-9	2011	An increased percentage of immunoreactive cells and a higher staining intensity in cancerous vs. non-cancerous paraffin sections paralleled higher mRNA levels of OATP2A1, OATP3A1, OATP4A1 and OATP5A1 in cancerous tissues of HCC, CCC and MLT patients.	Paraffin	111-119	solute carrier organic anion transporter family member 2A1	Homo sapiens	162-169
15000843-0	2004	Wild-type estrogen receptor beta expression in normal and neoplastic paraffin-embedded tissues.	Paraffin	69-77	estrogen receptor 2	Homo sapiens	10-32
15000843-1	2004	Recently, several antibodies have allowed the detection of estrogen receptor beta (ER-beta) in paraffin-embedded tissue; however, these attempts have failed to specifically identify the wild-type form and revealed technical difficulties such as the necessity for alterations to standard staining protocols and amplification detection systems.	Paraffin	95-103	estrogen receptor 2	Homo sapiens	59-81
21251909-5	2011	Paraffin-embedded human tissues of BPH and PC were used to examine LRF expression.	Paraffin	0-8	zinc finger and BTB domain containing 7A	Homo sapiens	67-70
15000843-1	2004	Recently, several antibodies have allowed the detection of estrogen receptor beta (ER-beta) in paraffin-embedded tissue; however, these attempts have failed to specifically identify the wild-type form and revealed technical difficulties such as the necessity for alterations to standard staining protocols and amplification detection systems.	Paraffin	95-103	estrogen receptor 2	Homo sapiens	83-90
15000843-2	2004	The aim of this study was to generate a monoclonal antibody that could provide enhanced sensitivity for detection of ER-beta in paraffin embedded tissues.	Paraffin	128-136	estrogen receptor 2	Homo sapiens	117-124
14569466-3	2004	METHOD: Immunohistochemical analysis of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expression was carried out in paraffin-embedded sections of surgically resected esophageal squamous cell carcinoma (ESCC) (58 cases) and paired distal normal esophageal tissues (44 cases) and correlated with clinicopathological parameters.	Paraffin	144-152	matrix metallopeptidase 2	Homo sapiens	40-66
14694526-0	2004	Evaluation of MDM2 and CDK4 amplification by real-time PCR on paraffin wax-embedded material: a potential tool for the diagnosis of atypical lipomatous tumours/well-differentiated liposarcomas.	Paraffin	62-74	cyclin dependent kinase 4	Homo sapiens	23-27
20413684-7	2010	In situ PCR was then performed to detect the mouse X chromosome-linked phosphoglycerate kinase-1 (pgk-1) gene on the paraffin sections.	Paraffin	117-125	phosphoglycerate kinase 1	Mus musculus	98-103
20428818-5	2010	Validation study using real-time quantitative RT-PCR in formalin-fixed paraffin-embedded cancer tissues and paired normal epithelia obtained by Laser-captured microdissection revealed that miR-205 showed highest expression in both malignant and benign squamous epithelia, although it was less expressed in cell lines and tissues other than squamous epithelia.	Paraffin	71-79	microRNA 205	Homo sapiens	189-196
21537090-3	2011	METHODS: Immunohistochemistry for cyclin D1 and DNA flowcytometry for cell cycle parameters was done on paraffin embedded tumour samples from 45 patients with OSCC RESULTS: Higher expression of cyclin D1 was observed only in 30 (66.6%) of 45 cases that correlated with advanced age (P &lt;0.02), higher tumour stage (P&lt;0.01), histological differentiation and lymph node metastasis (P &lt;0.01).	Paraffin	104-112	cyclin D1	Homo sapiens	194-203
15034217-4	2004	Expression of cyclin D1 and p53 was analyzed using standard immunohistochemical method of B5-fixed and routinely processed paraffin-embedded bone marrow specimens.	Paraffin	123-131	cyclin D1	Homo sapiens	14-23
21738817-2	2011	In this study the differential expressions of candidate proteins nucleophosmin, nucleoside diphosphate kinase A/B (NDKA/B), osteoinducive factor (mimecan), and pyru-vate kinase M2 from a quantitative proteome signature for invasive ductal breast cancer were determined by immunohistochemistry on 53 tissue slices from formalin-fixed and paraffin-embedded tumor and control tissue samples from ten patients and fourteen controls.	Paraffin	337-345	nucleophosmin 1	Homo sapiens	65-78
15103201-5	2004	RESULT: A specific chimeric gene, the SSX-SYT fusion gene, was identified in the formalin-fixed paraffin-embedded surgical specimen using the reverse-transcription polymerase chain reaction (RT-PCR) technique.	Paraffin	96-104	synaptotagmin 1	Homo sapiens	42-45
20156214-7	2010	Immunohistochemical analysis of formalin-fixed paraffin-embedded (FFPE) breast cancer tissues revealed higher TLR9 protein expression in hormone-receptor (HR)-negative specimens (n = 116, P &lt; 0.001).	Paraffin	47-55	toll like receptor 9	Homo sapiens	110-114
21343393-5	2011	These 2 independent lines of evidence relied upon the generation of a novel tool, an anti-TLR3 antibody (40F9.6) validated for routine detection of TLR3 expression on paraffin-embedded tissues.	Paraffin	167-175	toll like receptor 3	Homo sapiens	90-94
20196862-3	2010	RESULTS: Podoplanin expression was determined by immunohistochemistry in paraffin-embedded tissue specimens from 84 patients with laryngeal premalignancies and 53 patients with laryngeal squamous cell carcinomas.	Paraffin	73-81	podoplanin	Homo sapiens	9-19
20056739-4	2010	RESULTS: The RT-PCR assay is applicable for detecting the various described fusion transcripts of PAX8/PPARG in formalin-fixed, paraffin-embedded thyroid tissue and in fine-needle aspirate biopsy washes from thyroid nodules.	Paraffin	128-136	paired box 8	Homo sapiens	98-102
14693064-4	2003	METHODS: Immunohistochemical assay with the LSAB immunostaining technique was used to determine protein expression of P-gp and LRP in the specimens of paraffin-embedded tissues from 151 cases of breast carcinoma and 40 normal breast tissues (control).	Paraffin	151-159	major vault protein	Homo sapiens	127-130
14613648-9	2003	(3) In 42 paraffin-embedded GCT specimens, the positive expression rates of NOS1, NOS2, and NOS3 protein were 85.7%, 59.5%, and 31.0% in MGC, 54.8%, 28.6%, and 14.3% in MC, respectively.	Paraffin	10-18	nitric oxide synthase 1	Homo sapiens	76-80
21343393-5	2011	These 2 independent lines of evidence relied upon the generation of a novel tool, an anti-TLR3 antibody (40F9.6) validated for routine detection of TLR3 expression on paraffin-embedded tissues.	Paraffin	167-175	toll like receptor 3	Homo sapiens	148-152
14585093-5	2003	METHODS: Gal3 immunoperoxidase reaction was carried out on 91 sections of thyroid gland samples fixed in formalin and embedded in paraffin.	Paraffin	130-138	galectin 3	Homo sapiens	9-13
21283737-0	2011	Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay.	Paraffin	95-103	hepatocyte growth factor	Homo sapiens	13-37
21283737-0	2011	Detection of hepatocyte growth factor (HGF) ligand-c-MET receptor activation in formalin-fixed paraffin embedded specimens by a novel proximity assay.	Paraffin	95-103	hepatocyte growth factor	Homo sapiens	39-42
19004480-5	2010	The immunolocalisation of cofilin was studied by immunohistochemistry in 34 formalin-fixed, paraffin wax-embedded gastrointestinal endocrine cell tumors using a tissue microarray platform.	Paraffin	92-104	cofilin 1	Homo sapiens	26-33
22553708-2	2011	METHODS: Immunohistochemical technique was used to detect the expression of MMP-2 and MMP-9 in 41 cases of paraffin embedded Rb samples.	Paraffin	107-115	matrix metallopeptidase 2	Homo sapiens	76-81
20037605-7	2010	The housekeeping gene GUSB exhibited low variation of expression in frozen and paraffin-embedded lung tissues, whereas PGK1 had the lowest variation in lymphoma tissues.	Paraffin	79-87	glucuronidase beta	Homo sapiens	22-26
14535549-4	2003	The objectives of this study were 1) to compare biochemical typing with DNA typing of transferrin, 2) to determine if transferrin DNA from archival paraffin-embedded tissue samples can be recovered and typed with molecular methods, and 3) to determine if there was an association between foal death caused by R. equi and transferrin type.	Paraffin	148-156	inhibitor of carbonic anhydrase	Equus caballus	118-129
14535549-4	2003	The objectives of this study were 1) to compare biochemical typing with DNA typing of transferrin, 2) to determine if transferrin DNA from archival paraffin-embedded tissue samples can be recovered and typed with molecular methods, and 3) to determine if there was an association between foal death caused by R. equi and transferrin type.	Paraffin	148-156	inhibitor of carbonic anhydrase	Equus caballus	118-129
21472357-2	2010	Immunohistochemistry was performed in order to assess the expression pattern of TXR1 in paraffin-embedded specimens of 107 GC patients who underwent radical D2 gastrectomy with long-term follow-up.	Paraffin	88-96	proline rich 13	Homo sapiens	80-84
14513578-2	2003	METHODS: By immunohistochemical analysis in 200 paraffin-embedded tissues of OSCC and Western Blot in 9 fresh tissues of OSCC using a monoclonal antibody, the expression of nm23-H1/NDPK-A were detected in dividing groups accompanied with the clinical and pathological data of cervical lymph node metastases and modes of invasion.	Paraffin	48-56	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	173-180
20359085-2	2009	METHOD: Ninety-two cases of paraffin section with immunoperoxidase (SP) staining method was used to detect the distribution of Pin1 and CyclinD1 in 10 cases of laryngeal normal epithelial tissue, 39 cases of laryngeal papilloma, 27 cases of laryngeal papilloma with middle, severe atypical hyperplasia and 16 cases of laryngeal carcinoma.	Paraffin	28-36	cyclin D1	Homo sapiens	136-144
20813971-4	2010	Similar patterns for CFH and MAC were observed for RPE cells when serial paraffin sections of the laser spots were analyzed.	Paraffin	73-81	complement component factor h	Mus musculus	21-24
19930704-2	2009	METHODS: The expressions of P-gp, LRP and MRP in formalin-fixed paraffin-embedded tissue sections from 59 gastric cancer patients were determined by a labbelled Streptavidin-Peroxidase (SP) immunohistochemical technique, and the results were analyzed in correlation with clinicopathological data.	Paraffin	64-72	ATP binding cassette subfamily C member 3	Homo sapiens	42-45
20009901-3	2009	METHODS: Nuclear factor-kappaB subunits p65 and p50 were detected in 159 paraffin tissues including normal cervical, precancerous (squamous intraepithelial lesions), and cervical carcinoma tissues by immunohistochemistry.	Paraffin	73-81	RELA proto-oncogene, NF-kB subunit	Homo sapiens	40-43
12801267-1	2003	The immunohistochemical expression of cathepsin D was performed in paraffin embedded tissue from 79 endometrial carcinomas, 35 cases of hyperplasia, and 32 normal endometrium using the streptavidin-biotin method to investigate the role of cathepsin D (CD) in these lesions and its possible relationship with other potential and established prognostic markers.	Paraffin	67-75	cathepsin D	Homo sapiens	38-49
12697480-2	2003	METHOD: Immunohistochemical staining for PR and HER2 was performed on paraffin embedded tumor specimens obtained from 185 patients with breast cancer, and follow-up studies were conducted and the survival time of the patients recorded.	Paraffin	70-78	progesterone receptor	Homo sapiens	41-43
20847290-0	2010	A molecular profile of focal segmental glomerulosclerosis from formalin-fixed, paraffin-embedded tissue.	Paraffin	79-87	actinin alpha 4	Homo sapiens	23-57
20811686-5	2010	Methylation-specific PCR (MSP) was performed to study inactivation of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes in 37 cases of paraffin embedded oral cancer.	Paraffin	136-144	secreted frizzled related protein 1	Homo sapiens	70-76
12769341-2	2003	Polymerase chain reaction (PCR) has been used with increasing frequency to detect clonal rearrangements of the immunoglobulin heavy chain (IgH) in formaldehyde fixed, paraffin wax embedded tissues.	Paraffin	167-179	immunoglobulin heavy constant delta	Homo sapiens	111-137
12769341-2	2003	Polymerase chain reaction (PCR) has been used with increasing frequency to detect clonal rearrangements of the immunoglobulin heavy chain (IgH) in formaldehyde fixed, paraffin wax embedded tissues.	Paraffin	167-179	immunoglobulin heavy constant delta	Homo sapiens	139-142
19527987-4	2009	Fascin expression was investigated through the immunohistochemistry of paraffin-embedded tissue in 73 cases of melanocytic lesions of the skin, including 20 benign nevi, 12 dysplastic nevi, 4 lentigo malignas, 25 malignant melanomas and 12 metastatic melanomas.	Paraffin	71-79	fascin actin-bundling protein 1	Homo sapiens	0-6
20808855-3	2010	METHODOLOGY/PRINCIPAL FINDINGS: FAAH immunoreactivity (FAAH-IR) was assessed in formalin-fixed paraffin-embedded non-malignant and tumour cores from 412 patients with prostate cancer.	Paraffin	95-103	fatty-acid amide hydrolase-like	Rattus norvegicus	55-59
19671866-2	2009	Previous studies have separately reported elevated expression of BSP, OPN, or DSPP in prostate tumor paraffin sections.	Paraffin	101-109	dentin sialophosphoprotein	Homo sapiens	78-82
20564221-0	2010	Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues.	Paraffin	131-139	TIMP metallopeptidase inhibitor 4	Homo sapiens	63-102
20163606-5	2009	Paraffin sections of the mammary gland were immunostained with LAP antibody.	Paraffin	0-8	lingual antimicrobial peptide	Bos taurus	63-66
12602907-6	2003	Expression of MMP-2 was studied in paraffin-embedded tissue sections from primary tumors using a specific monoclonal antibody for MMP-2 in an avidin-biotin-peroxidase immunohistochemical staining.	Paraffin	35-43	matrix metallopeptidase 2	Homo sapiens	14-19
20564221-0	2010	Development of a monoclonal antibody that specifically detects tissue inhibitor of metalloproteinase-4 (TIMP-4) in formalin-fixed, paraffin-embedded human tissues.	Paraffin	131-139	TIMP metallopeptidase inhibitor 4	Homo sapiens	104-110
12538472-3	2003	EXPERIMENTAL DESIGN: p125(FAK) expression in formalin-fixed paraffin-embedded (FFPE) tissue was studied using immunohistochemical assays on 24 matched primary colorectal carcinomas and colorectal liver metastases as well as 18 different colorectal liver metastases using monoclonal anti-FAK 4.47.	Paraffin	60-68	protein tyrosine kinase 2	Homo sapiens	26-29
20564221-6	2010	In contrast, the antibody displayed high specificity and sensitivity for TIMP-4 including in formalin-fixed and paraffin-embedded specimens of human breast specimens.	Paraffin	112-120	TIMP metallopeptidase inhibitor 4	Homo sapiens	73-79
19483633-4	2009	Fascin expression was investigated through the immunohistochemistry of paraffin-embedded tissue in 79 cases of uterine smooth muscle tumor including 22 usual leiomyoma, 31 LV, 4 STUMP, and 22 LMS cases.	Paraffin	71-79	fascin actin-bundling protein 1	Homo sapiens	0-6
20557864-2	2010	METHODS: Using the fluorescence property of QDs and indirect immunofluorescence methods to detect the IgA and complement C3 in formalin-fixed paraffin-embedded (FFPE) tissues of IgAN.	Paraffin	142-150	IGAN1	Homo sapiens	178-182
19430293-0	2009	A novel JAK2 exon 12 mutation identified in the retrospective analysis of paraffin-embedded tissues of polycythemia vera patients.	Paraffin	74-82	Janus kinase 2	Homo sapiens	8-12
19430293-1	2009	The aim of the study was to screen formalin-fixed, paraffin-embedded tissues of polycythemia vera patients for the presence of JAK2(V617F) and JAK2 exon 12 mutations.	Paraffin	51-59	Janus kinase 2	Homo sapiens	127-131
19430293-1	2009	The aim of the study was to screen formalin-fixed, paraffin-embedded tissues of polycythemia vera patients for the presence of JAK2(V617F) and JAK2 exon 12 mutations.	Paraffin	51-59	Janus kinase 2	Homo sapiens	143-147
19430293-8	2009	We confirmed that paraffin-embedded tissues represent a valuable source of DNA, which can be used in diagnostics of both JAK2 exon 12 and exon 14 mutations and we described 1 novel JAK2 exon 12 mutation.	Paraffin	18-26	Janus kinase 2	Homo sapiens	121-125
19430293-8	2009	We confirmed that paraffin-embedded tissues represent a valuable source of DNA, which can be used in diagnostics of both JAK2 exon 12 and exon 14 mutations and we described 1 novel JAK2 exon 12 mutation.	Paraffin	18-26	Janus kinase 2	Homo sapiens	181-185
23365501-3	2003	Expression of retinoblastoma gene protein product (pRB) was investigated in 118 formalin-fixed, paraffin-embedded cervical tissues by immunohistochemistry using commercially available antibody directed against RB protein.	Paraffin	96-104	RB transcriptional corepressor 1	Homo sapiens	14-28
23365501-3	2003	Expression of retinoblastoma gene protein product (pRB) was investigated in 118 formalin-fixed, paraffin-embedded cervical tissues by immunohistochemistry using commercially available antibody directed against RB protein.	Paraffin	96-104	RB transcriptional corepressor 1	Homo sapiens	51-54
20214994-9	2010	Immunohistochemical analysis of paraffin embedded skin wounds from mice showed that MMP-9 protein was localized at the leading-edge keratinocytes in front of the migrating epidermal layer.	Paraffin	32-40	matrix metallopeptidase 9	Mus musculus	84-89
12520742-8	2002	Expression of LRP in 50 paraffin specimens of ovarian cancer was determined using immunohistochemistry.	Paraffin	24-32	major vault protein	Homo sapiens	14-17
20042850-6	2010	The absence of JAK2 demonstrated in the paraffin samples of the tumors may be related to the unusual evolution in this particular case.	Paraffin	40-48	Janus kinase 2	Homo sapiens	15-19
12446380-5	2002	Immunohistochemistry was performed for Smads3/4 in paraffin sections of the specimens.	Paraffin	51-59	SMAD family member 3	Homo sapiens	39-47
12473599-3	2002	We developed an immunohistochemical assay suitable for the detection of pRb2/p130, the last discovered member of the retinoblastoma gene family, on formalin-fixed and paraffin-embedded sections.	Paraffin	167-175	proline rich protein BstNI subfamily 2	Homo sapiens	72-76
19329940-6	2009	Further, immunohistochemical staining for transgelin was performed on paraffin sections of 62 and 126 cases of normal colorectal mucosa and colorectal cancer specimens, respectively.	Paraffin	70-78	transgelin	Homo sapiens	42-52
19178934-3	2009	Immunohistochemical staining was performed to assess ER and PR expression in paraffin-embedded ovarian cancers.	Paraffin	77-85	progesterone receptor	Homo sapiens	60-62
20426910-5	2010	The expression of Skp2 was examined by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.	Paraffin	79-87	S-phase kinase associated protein 2	Homo sapiens	18-22
19242719-0	2009	The detection of CD14 and CD16 in paraffin-embedded bone marrow biopsies is useful for the diagnosis of chronic myelomonocytic leukemia.	Paraffin	34-42	CD14 molecule	Homo sapiens	17-21
12428799-4	2002	We examined clusterin expression by paraffin immunohistochemical analysis in 41 systemic ALCLs (18 ALK-1+ and 23 ALK-1-), 9 primary cutaneous ALCLs, and 4 secondary cutaneous ALCLs.	Paraffin	36-44	clusterin	Homo sapiens	12-21
19898867-4	2010	METHODS: In present study, we investigated HMGB1 expression and its prognostic significance in CRC by performing immunohistochemical analysis, using a total of 192 paraffin-embedded archival CRC samples.	Paraffin	164-172	high mobility group box 1	Homo sapiens	43-48
12411587-2	2002	We used a real-time quantitative reverse transcription-polymerase chain reaction (qRT-PCR) method to quantify levels of cyclin D1, CD20, and cyclophilin A mRNA in manually microdissected, paraffin-embedded tissue sections using an ABI 7700 qRT-PCR system.	Paraffin	188-196	cyclin D1	Homo sapiens	120-129
19221643-4	2009	We investigated the cathepsin-D expression in these breast lesions using immunohistochemistry (IH; paraffin-embedded tissues).	Paraffin	99-107	cathepsin D	Homo sapiens	20-31
18612800-1	2008	The aim of the present study was to investigate the localization and distribution of the putative brain tumour stem cell marker CD133 in formalin fixed paraffin embedded astrocytomas.	Paraffin	152-160	prominin 1	Homo sapiens	128-133
12170088-2	2002	We report here the analyses of PAX8-PPARgamma in a series of 118 thyroid tumors using a newly developed RT-PCR assay to detect this rearrangement in frozen and paraffin-embedded tissues and using immunostaining with a PPARgamma antibody.	Paraffin	160-168	paired box 8	Homo sapiens	31-35
18612800-3	2008	The immunohistochemical expression of CD133 in paraffin sections was analysed using morphometry.	Paraffin	47-55	prominin 1	Homo sapiens	38-43
19915453-6	2010	Patients with XPC can therefore be diagnosed by IHC from paraffin-embedded skin biopsies from regions of skin that are without sun damage or sun-induced tumors.	Paraffin	57-65	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	14-17
18925697-3	2008	We determined the expression of MMP-2 in 152 formalin-fixed, paraffin embedded specimens of Duke"s B colon carcinomas by immunohistochemical analysis using MMP-2 monoclonal antibody.	Paraffin	61-69	matrix metallopeptidase 2	Homo sapiens	32-37
12354520-1	2002	The expression of mRNA encoding interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of PRRSV.	Paraffin	269-281	interferon gamma	Sus scrofa	32-48
19915453-8	2010	This fast and inexpensive method should increase the options for the diagnosis of patients with XPC from paraffin-embedded skin biopsies and could be developed for other complementation groups.	Paraffin	105-113	XPC complex subunit, DNA damage recognition and repair factor	Homo sapiens	96-99
12354520-1	2002	The expression of mRNA encoding interferon-gamma (IFN-gamma) and tumour necrosis factor-alpha (TNF-alpha) was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of PRRSV.	Paraffin	269-281	tumor necrosis factor	Sus scrofa	95-104
19614992-4	2010	METHODS: We used a commercially available antibody to K75 on formalin-fixed, paraffin-embedded tissue from clinically and histologically "normal" scalp (n=9); clinically diseased scalp from patients with CCCA (n=15); and clinically "normal" scalp from patients with CCCA (n=6).	Paraffin	77-85	keratin 75	Homo sapiens	54-57
12123792-10	2002	These results indicate that PgR636 and PgR1294 are optimal antibodies for IHC detection of PR in routine paraffin tissue blocks.	Paraffin	105-113	progesterone receptor	Homo sapiens	91-93
18785805-10	2008	This technology forms the basis for the Previstagetrade mark GCC Colorectal Cancer Staging Test encompassing a proprietary multiplex qRT-PCR assay compatible with formalin-fixed, paraffin-embedded lymph nodes for detecting occult metastases.	Paraffin	179-187	guanylate cyclase 2C	Homo sapiens	61-64
18355177-7	2008	CONCLUSION: Chromogenic double staining of CD4/FoxP3 is a promising tool for the detection of Treg in paraffin-embedded tissue of OSCC.	Paraffin	102-110	forkhead box P3	Homo sapiens	47-52
19912575-3	2010	Immunohistochemistry analysis of frozen and paraffin-embedded tissue samples, applying an extended panel of specific anti-HLA monoclonal antibodies, showed elevated HLA class I antigen expression in 95.6% of the tumors vs only 12.9% of normal renal tissues.	Paraffin	44-52	MHC class I polypeptide-related sequence A	Homo sapiens	165-184
18413654-0	2008	FOXP3 immunohistochemistry on formalin-fixed paraffin-embedded tissue: poor correlation between different antibodies.	Paraffin	45-53	forkhead box P3	Homo sapiens	0-5
18413654-6	2008	This report describes the experience of using two commonly used monoclonal FOXP3 antibodies on formalin-fixed paraffin-embedded sections of different organs, including the cervix and vulva.	Paraffin	110-118	forkhead box P3	Homo sapiens	75-80
12150740-0	2002	Detection of SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction.	Paraffin	43-51	synaptotagmin 1	Homo sapiens	13-16
12150740-0	2002	Detection of SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction.	Paraffin	43-51	SSX family member 2	Homo sapiens	17-20
12150740-1	2002	OBJECTIVE: To assess the feasibility of detecting SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction (RT-PCR).	Paraffin	80-88	synaptotagmin 1	Homo sapiens	50-53
12150740-1	2002	OBJECTIVE: To assess the feasibility of detecting SYT-SSX fusion transcripts in paraffin-embedded tissues of synovial sarcoma by reverse transcription-polymerase chain reaction (RT-PCR).	Paraffin	80-88	SSX family member 2	Homo sapiens	54-57
12150740-2	2002	METHODS: RT-PCR was used to amplify the SYT-SSX fusion transcripts using archival formalin-fixed paraffin-embedded tumor specimens from a series of 37 synovial sarcoma cases.	Paraffin	97-105	synaptotagmin 1	Homo sapiens	40-43
12150740-2	2002	METHODS: RT-PCR was used to amplify the SYT-SSX fusion transcripts using archival formalin-fixed paraffin-embedded tumor specimens from a series of 37 synovial sarcoma cases.	Paraffin	97-105	SSX family member 2	Homo sapiens	44-47
18632638-4	2008	Here, we characterized the PAFR expression pattern in 4 normal human ovarian surface epithelial (HOSE) cell lines, 13 ovarian cancer cell lines, paraffin blocks (n = 84), and tissue microarrays (n = 230) from patients with ovarian cancer.	Paraffin	145-153	platelet activating factor receptor	Homo sapiens	27-31
20588040-5	2010	We evaluated the immunohistochemical expression of CA-9 in the paraffin-embedded specimens of 265 gastric adenocarcinomas.	Paraffin	63-71	carbonic anhydrase 9	Homo sapiens	51-55
12118104-5	2002	Expression of galectin-3, a nonintegrin beta-galactosidase-binding lectin, has been reported to be significant in PLGA and decreased in ACC.Formalin-fixed paraffin-embedded tissue from 9 ACC and 14 PLGA were immunostained for c-kit and galectin-3.	Paraffin	155-163	galectin 3	Homo sapiens	14-24
12428063-4	2002	MATERIAL AND METHODS: The expression of MRP1, MRP2, MRP3, MDR1, and MDR3 was investigated by quantitative RT-PCR analyses in paraffin-embedded tissues obtained from 9 cases of HCC, 16 cases of cirrhosis, 10 cases of chronic extrahepatic cholestasis, and 16 cases of normal liver.	Paraffin	125-133	mutS homolog 3	Homo sapiens	40-44
20204254-11	2010	The cytoplasmic expression of COX-2 protein was studied in paraffin sections of the colon by immunohistochemistry with COX-2 specific antibody which showed a very high presence of this inducible enzyme with the DMH group while in all other groups of animals it was not visible or weekly expressed.	Paraffin	59-67	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	30-35
12000707-3	2002	We detected the biosynthetic enzyme histidine decarboxylase by immunohistochemistry in paraffin sections of 12 biopsies of SCLC tumors.	Paraffin	87-95	histidine decarboxylase	Homo sapiens	36-59
18387992-6	2008	The presence of an SYT-SSX gene fusion resulting from t(X;18) was demonstrated from paraffin blocks by reverse transcriptase polymerase chain reaction in both cases.	Paraffin	84-92	synaptotagmin 1	Homo sapiens	19-22
18587209-5	2008	The detection and activity of two MMPs (2 and 9) were performed by immunohistochemistry in formalin-fixed, paraffin-embedded sections of odontogenic myxoma and immunofluorescence of the cultured cells and, by gelatin zymographic analysis of Mix1 conditioned media, respectively.	Paraffin	107-115	matrix metallopeptidase 2	Homo sapiens	34-38
19824120-2	2009	METHODS: Immunohistochemistry was used to detect LRP16 expression in 336 cases of paraffin-embedded gastric carcinoma tissues and 60 cases of distal normal mucosa.	Paraffin	82-90	mono-ADP ribosylhydrolase 1	Homo sapiens	49-54
12905795-0	2002	[Alterations of DPC4/SMAD4/MADH4 gene detected in paraffin-embedded tissues of human pancreatic carcinomas].	Paraffin	50-58	SMAD family member 4	Homo sapiens	16-20
12905795-0	2002	[Alterations of DPC4/SMAD4/MADH4 gene detected in paraffin-embedded tissues of human pancreatic carcinomas].	Paraffin	50-58	SMAD family member 4	Homo sapiens	21-26
12905795-0	2002	[Alterations of DPC4/SMAD4/MADH4 gene detected in paraffin-embedded tissues of human pancreatic carcinomas].	Paraffin	50-58	SMAD family member 4	Homo sapiens	27-32
12905795-1	2002	OBJECTIVE: To demonstrate the alterations of DPC4/SMAD4/MADH4 gene in paraffin-embedded tissues of pancreatic carcinomas.	Paraffin	70-78	SMAD family member 4	Homo sapiens	45-49
12905795-1	2002	OBJECTIVE: To demonstrate the alterations of DPC4/SMAD4/MADH4 gene in paraffin-embedded tissues of pancreatic carcinomas.	Paraffin	70-78	SMAD family member 4	Homo sapiens	50-55
12905795-1	2002	OBJECTIVE: To demonstrate the alterations of DPC4/SMAD4/MADH4 gene in paraffin-embedded tissues of pancreatic carcinomas.	Paraffin	70-78	SMAD family member 4	Homo sapiens	56-61
17517527-1	2008	Cyclooxygenase(COX)-2 expression was evaluated in 24 paraffin-embedded canine nasal carcinoma tissue samples by immunohistochemistry.	Paraffin	53-61	cytochrome c oxidase subunit II	Canis lupus familiaris	0-21
19797419-5	2009	METHODS: We analyzed the expression of the BMP-2 antigen in a series of 98 gliomas of various grade and histology by immunohistochemistry on paraffin-embedded sections.	Paraffin	141-149	bone morphogenetic protein 2	Homo sapiens	43-48
18705404-2	2008	MATERIAL AND METHODS: The expression of CD40 on paraffin-embedded ovarian cancer tissues (n=58) and normal ovarian tissues (n=15) was tested by immunohistochemistry, and CD40 expression on ovarian cancer cells derived from fresh surgical specimens was tested by flow cytometry analysis.	Paraffin	48-56	CD40 molecule	Homo sapiens	40-44
18705404-4	2008	RESULTS: CD40 expression was detected in 60.3% (35/58) of paraffin-embedded ovarian cancer tissues and 73.3% (11/15) of fresh ovarian cancer tissues, but not in normal ovarian tissues (n=15).	Paraffin	58-66	CD40 molecule	Homo sapiens	9-13
18188593-3	2008	We conducted this study trying to elucidate the role of NFkappaB in bladder UC and its potential prognostic significance, by quantifying immunohistochemically the levels of p65/RelA expression in paraffin-embedded tissue from 116 patients.	Paraffin	196-204	RELA proto-oncogene, NF-kB subunit	Homo sapiens	173-176
18188593-3	2008	We conducted this study trying to elucidate the role of NFkappaB in bladder UC and its potential prognostic significance, by quantifying immunohistochemically the levels of p65/RelA expression in paraffin-embedded tissue from 116 patients.	Paraffin	196-204	RELA proto-oncogene, NF-kB subunit	Homo sapiens	177-181
12419158-2	2002	METHODS: Detecting FHIT protein expression in 60 cases of formalin-fixed, paraffin-embedded colorectal carcinoma by citrate-microwave-SP immunohistochemical method, and analyzing its relationship to histological grade, Dukes" stage and 5-year survival rate.	Paraffin	74-82	fragile histidine triad diadenosine triphosphatase	Homo sapiens	19-23
11879807-8	2002	Immunolocalization of the SOD1 and SOD2 proteins in paraffin-embedded tissue sections revealed a marked increase in the density of SOD immunopositive profiles (particularly glia) in the typical PSP brain, particularly within the white matter.	Paraffin	52-60	superoxide dismutase 2	Homo sapiens	35-39
19723143-4	2009	METHODS AND RESULTS: The expression of the CD133 stem cell antigen in a series of 73 patients with rectal cancer of various ypTNM stages was analysed by immunohistochemistry on formalin-fixed paraffin-embedded sections.	Paraffin	192-200	prominin 1	Homo sapiens	43-48
11854597-2	2002	In this study, the authors describe a new real-time reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect SYT/SSX fusion transcripts using paraffin-embedded and frozen tumor specimens.	Paraffin	159-167	synaptotagmin 1	Homo sapiens	126-129
18212749-1	2008	To evaluate whether parvovirus B19, a common human pathogen, was also involved in papillary thyroid carcinoma (PTC), 112 paraffin-embedded thyroid specimens of benign nodules, papillary, medullary and follicular carcinomas, and normal controls were examined for B19 DNA and capsid protein by nested PCR, in situ hybridisation (ISH) and immunohistochemistry (IHC).	Paraffin	121-129	eva-1 homolog C	Homo sapiens	31-34
19521280-5	2009	Paraffin immunohistochemistry showed finely granular cytoplasmic ALK1 expression, positive CD138, IgA, p63 (VS38), focal positive epithelial membrane antigen and CD4, and lambda light chain restriction whereas negative CD20 and CD30 staining.	Paraffin	0-8	syndecan 1	Homo sapiens	91-96
19223510-3	2009	EXPERIMENTAL DESIGN: Immunohistochemistry and Western blot were used to determine Ubc9 expression in paraffin-embedded tumor tissue and frozen specimens of the matched tumors from the same patient, respectively.	Paraffin	101-109	ubiquitin conjugating enzyme E2 I	Homo sapiens	82-86
11979374-5	2002	In 10 of these cases in which paraffin-embedded tissue was available for study, CD69 immunohistochemical staining of paraffin sections correlated with frozen section expression.	Paraffin	30-38	CD69 molecule	Homo sapiens	80-84
11979374-5	2002	In 10 of these cases in which paraffin-embedded tissue was available for study, CD69 immunohistochemical staining of paraffin sections correlated with frozen section expression.	Paraffin	117-125	CD69 molecule	Homo sapiens	80-84
11979374-6	2002	CD69 immunostaining was performed on paraffin sections from 53 additional cases of peripheral T cell lymphoma and correlated with immunoreactivity for other Th1 differentiation markers (P &lt; 0.0001) and was associated with specific subtypes of peripheral T cell lymphoma, including angioimmunoblastic lymphoma, Lennert"s lymphoma, and mycosis fungoides/Sezary syndrome, previously noted to express Th1 differentiation-associated markers.	Paraffin	37-45	CD69 molecule	Homo sapiens	0-4
11979374-9	2002	In addition, CD69 is a useful immunohistochemical marker for specific T cell lymphomas in frozen and paraffin-embedded tissue.	Paraffin	101-109	CD69 molecule	Homo sapiens	13-17
17893871-4	2008	PAR-4 expression levels were analyzed in 4 established pancreatic tumor cell lines, 10 normal pancreatic tissues, 44 frozen tumor tissues and 25 paraffin-embedded pancreatic adenocarcinoma samples by Real Time RT-PCR, Western blot analysis and immunohistochemistry.	Paraffin	145-153	Prader Willi/Angelman region RNA 4	Homo sapiens	0-5
17893871-10	2008	Of 25 paraffin-embedded tumors, 9 showed downregulation of PAR-4 protein and this downregulation of PAR-4 correlated significantly with K-ras mutational status (p &lt; 0.00002).	Paraffin	6-14	Prader Willi/Angelman region RNA 4	Homo sapiens	59-64
19225135-4	2009	We developed a single-tube multiplex TaqMan (mERPR+HER2) assay to quantitate mRNA levels of ER, PR, HER2, and two housekeeping genes for breast cancer formalin-fixed, paraffin-embedded sections.	Paraffin	167-175	progesterone receptor	Homo sapiens	48-50
17893871-10	2008	Of 25 paraffin-embedded tumors, 9 showed downregulation of PAR-4 protein and this downregulation of PAR-4 correlated significantly with K-ras mutational status (p &lt; 0.00002).	Paraffin	6-14	Prader Willi/Angelman region RNA 4	Homo sapiens	100-105
11826189-3	2002	We have developed a real-time, reverse transcriptase-polymerase chain reaction (RT-PCR) multiplex assay for the identification of the primary fusion transcript types (SYT-SSX1 and SYT-SSX2) from formalin-fixed, paraffin-embedded (FFPE) tissues.	Paraffin	211-219	synaptotagmin 1	Homo sapiens	167-170
18553161-5	2009	Human genetic polymorphism Val16Ala of MnSOD was obtained from blood and paraffin-embedded tumor samples.	Paraffin	73-81	superoxide dismutase 2	Homo sapiens	39-44
12502190-2	2002	Immunohistochemical staining with monoclonal antibody against nm23 using LSAB2/HRP method on formalin-fixed, paraffin-embedded sections obtained from 32 tumors was performed.	Paraffin	109-117	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	62-66
11844241-1	2002	OBJECTIVE: In a previous study, we documented lower levels of immunoexpression of platelet endothelial cell (EC) adhesion molecule (CD31) in paraffin sections of cerebral cavernous malformations (CCMs), compared with arteriovenous malformations (AVMs) or normal brain tissue.	Paraffin	141-149	platelet and endothelial cell adhesion molecule 1	Homo sapiens	132-136
11844241-10	2002	CONCLUSION: The expression of CD31 in CCMs can be underestimated in paraffin sections.	Paraffin	68-76	platelet and endothelial cell adhesion molecule 1	Homo sapiens	30-34
19122826-6	2008	METHODS: Using immunofluorescence, we determined the expression of 14-3-3 beta, epsilon, gamma, eta, theta, sigma, and zeta in paraffin sections of the human cornea and conjunctiva.	Paraffin	127-135	endothelin receptor type A	Homo sapiens	75-78
19349673-2	2009	METHODS: EnVison immunohistochemistry was used to detect the expression of ubiquitin and cul-1 in the conventional paraffin-embedded sections from the specimens of lung cancer (n = 80) and benign lesion tissues of the lung (n = 20).	Paraffin	115-123	cullin 1	Homo sapiens	89-94
18097796-0	2007	Development of an optimal antigen retrieval protocol for immunohistochemistry of retinoblastoma protein (pRB) in formalin fixed, paraffin sections based on comparison of different methods.	Paraffin	129-137	RB transcriptional corepressor 1	Homo sapiens	105-108
11753987-5	2001	Immunohistochemistry using the catalyzed signal amplification system was employed to detect LANA and p53 on paraffin embedded tissues and the immunofluorescence technique was used on cell lines.	Paraffin	108-116	LANA	Human gammaherpesvirus 8	92-96
11753991-4	2001	METHODS: The immunohistochemical expression of TGF-alpha, EGF-R, and c-erb B-2 was studied in paraffin material of 62 clinical Wilms tumors.	Paraffin	94-102	transforming growth factor alpha	Homo sapiens	47-56
19056846-4	2009	CK2beta immunostaining was assessed in two tissue microarrays, one constructed from paraffin-embedded blocks of 95 ECs and another from 70 samples of normal endometrium.	Paraffin	84-92	casein kinase 2 beta	Homo sapiens	0-7
11688576-1	2001	CD31 (platelet endothelial adhesion molecule, PECAM-1) is generally regarded to be the most sensitive and specific endothelial marker in paraffin sections.	Paraffin	137-145	platelet and endothelial cell adhesion molecule 1	Homo sapiens	0-4
11688576-1	2001	CD31 (platelet endothelial adhesion molecule, PECAM-1) is generally regarded to be the most sensitive and specific endothelial marker in paraffin sections.	Paraffin	137-145	platelet and endothelial cell adhesion molecule 1	Homo sapiens	46-53
11688576-17	2001	CD31 may also be useful as a nonlysosomal marker of macrophages in formalin-fixed, paraffin-embedded sections.	Paraffin	83-91	platelet and endothelial cell adhesion molecule 1	Homo sapiens	0-4
18051796-1	2007	A 64-year-old man who ingested liquid paraffin as a laxative for over two years, was admitted to our hospital with a persistent interstitial lung shadow and marked elevation of serum KL-6.	Paraffin	38-46	mucin 1, cell surface associated	Homo sapiens	183-187
17948965-3	2007	We have raised a rabbit polyclonal antibody against a synthetic peptide that recognises denatured MICA on both Western blots and in formalin-fixed paraffin-embedded sections.	Paraffin	147-155	MHC class I polypeptide-related sequence A	Homo sapiens	98-102
11561755-1	2001	In order to confirm the presence of SYT-SSX fusion gene in epithelial and spindle cell components of synovial sarcoma, we performed a nested reverse transcriptase-polymerase chain reaction (RT-PCR) using microbeam microdissection of membrane-mounted native tissue (MOMeNT) technique applied on formalin-fixed, paraffin-embedded tumor specimens from two biphasic synovial sarcomas and a control tissue of adamantinoma.	Paraffin	310-318	synaptotagmin 1	Homo sapiens	36-39
19160091-2	2009	We tried to determine the methylation status and its impact on the expression of two tumor related genes Casp-8 and Rb1 in 103 bladder tumor tissues and 48 control paraffin-embedded tissues by using MSP-PCR and SQRT-PCR.	Paraffin	164-172	caspase 8	Homo sapiens	105-111
11315260-5	2001	METHOD: Immunohistochemical analysis of cyclin D1 expression was carried out in paraffin-embedded sections of surgically resected esophageal squamous cell carcinomas (ESCC) (70 patients) and matched with histopathologically normal esophageal tissues from a distant site.	Paraffin	80-88	cyclin D1	Homo sapiens	40-49
17954183-4	2007	Foxp3 staining was performed on paraffin-embedded sections with a monoclonal antibody after antigen retrieval.	Paraffin	32-40	forkhead box P3	Homo sapiens	0-5
11378551-3	2001	To elucidate the histogenesis of PCNSL, we analyzed the source of the cells from its variable region (VH) sequences using the polymerase chain reaction (PCR) method to amplify the immunoglobulin heavy chain (IgH) gene of DNA extracted from paraffin sections.	Paraffin	240-248	immunoglobulin heavy constant delta	Homo sapiens	208-211
19647948-3	2009	An anti-FAK antibody was used to study the protein expression in paraffin-embedded samples of normal and neoplastic, hematolymphoid and non-hematolymphoid tissues by immunohistochemistry.	Paraffin	65-73	protein tyrosine kinase 2	Homo sapiens	8-11
17705020-5	2007	Additional immunohistochemical analysis showed the negative expression of transferrin receptor (TfR) on the formalin-fixed paraffin-embedded specimen.	Paraffin	123-131	transferrin receptor	Homo sapiens	74-94
17705020-5	2007	Additional immunohistochemical analysis showed the negative expression of transferrin receptor (TfR) on the formalin-fixed paraffin-embedded specimen.	Paraffin	123-131	transferrin receptor	Homo sapiens	96-99
11253131-3	2001	METHODS: Immunohistochemical staining for TGF-beta RII was performed on 15 paraffin wax embedded biopsies from patients with precancerous laryngeal lesions who subsequently developed invasive squamous cell carcinoma of the larynx, and on 30 control biopsies from patients who did not develop cancer in a comparable follow up period.	Paraffin	75-87	transforming growth factor beta receptor 2	Homo sapiens	42-54
19647948-7	2009	We demonstrate for the first time the expression of FAK in paraffin-embedded hematolymphoid tissue samples.	Paraffin	59-67	protein tyrosine kinase 2	Homo sapiens	52-55
19886254-9	2009	The presence of vimentin, desmin and PCNA was detected immunohistochemically in sections prepared with a paraffin method.	Paraffin	105-113	vimentin	Sus scrofa	16-24
11159766-3	2001	METHODS: A quantitative real-time reverse transcription (RT)-PCR assay was developed for cyclin D1 mRNA suitable for use with RNA extracted from fresh and formalin-fixed, paraffin-embedded tissues.	Paraffin	171-179	cyclin D1	Homo sapiens	89-98
11223831-2	2001	METHODS: Expression of nm23 and MTS1 mRNA was determined by quantitative analysis from paraffin-embedded tumor tissue.	Paraffin	87-95	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	23-27
17641845-5	2007	Assessment of paraffin sections demonstrated that the expression of Cx43 protein in PCa cells was abnormally located and markedly diminished as compared with normal prostatic epithelial ones, displaying a negative correlation to the pathological grade (chi2=4.025, P&lt;0.05).	Paraffin	14-22	gap junction protein alpha 1	Homo sapiens	68-72
19088041-9	2008	An independent set of 406 paraffin-embedded tumors also revealed a high PMF1 methylation rate (77.6%).	Paraffin	26-34	polyamine modulated factor 1	Homo sapiens	72-76
11224869-7	2001	METHODS: In addition to the immunohistochemical study, a reverse transcription-polymerase chain reaction (RT-PCR) assay was conducted for the SYT-SS10 fusion gene using archival formalin-fixed paraffin-embedded tumor specimens.	Paraffin	193-201	synaptotagmin 1	Homo sapiens	142-145
18266960-7	2008	Paraffin sections of healthy bone and bone from patients with Paget"s disease and giant cell tumour of the bone were used to study Cx43 expression in vivo.	Paraffin	0-8	gap junction protein alpha 1	Homo sapiens	131-135
11245340-5	2001	Expression of the immunoreactive protein for MMP-2 was evaluated prospectively in this study in paraffin tissue sections from primary tumors of 100 postmenopausal, node-positive breast carcinoma patients treated with an adjuvant antiestrogen therapy.	Paraffin	96-104	matrix metallopeptidase 2	Homo sapiens	45-50
11305953-4	2001	MATERIALS AND METHODS: We studied the expression of the genes encoding multidrug resistance associated protein (MDR1) and lung cancer associated resistance protein (LRP) in formalin-fixed, paraffin-embedded tumor samples from 52 patients treated for locally advanced breast cancer by means of induction chemotherapy followed by rescue mastectomy.	Paraffin	189-197	ATP binding cassette subfamily C member 3	Homo sapiens	71-110
19033103-0	2008	[Primers for detecting gene rearrangement in different regions of immunoglobulin heavy chain genes and their application in diagnosis of paraffin-embedded lymphoma tissues].	Paraffin	137-145	immunoglobulin heavy constant delta	Homo sapiens	66-92
11172303-0	2001	Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists.	Paraffin	69-77	synaptotagmin 1	Homo sapiens	57-60
11194191-4	2000	Paraffin embedded skin tissues were stained with monoclonal antibodies to human ER and PR by immunohistochemistry.	Paraffin	0-8	progesterone receptor	Homo sapiens	87-89
19033103-1	2008	OBJECTIVE: To analyze and optimize the gene rearrangement primers of different frame regions (FR) of immunoglobulin heavy chain (IgH) genes by bioinformatic methods and explore the application of these primers in the detection of paraffin-embedded lymphoma tissues.	Paraffin	230-238	immunoglobulin heavy constant delta	Homo sapiens	101-127
19033103-1	2008	OBJECTIVE: To analyze and optimize the gene rearrangement primers of different frame regions (FR) of immunoglobulin heavy chain (IgH) genes by bioinformatic methods and explore the application of these primers in the detection of paraffin-embedded lymphoma tissues.	Paraffin	230-238	immunoglobulin heavy constant delta	Homo sapiens	129-132
19033103-8	2008	CONCLUSION: Primers from IgH FR3 region genes are more sensitive than that from the FR1 and FR2 regions in the detection of gene rearrangement in paraffin-embedded lymphoma tissues.	Paraffin	146-154	immunoglobulin heavy constant delta	Homo sapiens	25-28
11079730-4	2000	METHODS: Immunohistochemical analysis of pRb and p16INK4a proteins was carried out in paraffin-embedded sections from 61 surgically resected ESCCs and matched normal tissues, and the results correlated with clinicopathological parameters using chi square and Fisher"s exact tests.	Paraffin	86-94	RB transcriptional corepressor 1	Homo sapiens	41-44
18853312-2	2008	PTI-1 expression was evaluated in human prostate cancer cell lines and in paraffin-embedded archive tissues.	Paraffin	74-82	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	0-5
11131333-2	2000	Paraffin sections of healthy follicles and various stages of atretic and cystic follicles were immunostained with mouse monoclonal antibody to proliferating cell nuclear antigen (PCNA).	Paraffin	0-8	proliferating cell nuclear antigen	Bos taurus	179-183
17977643-3	2008	TRPV2 mRNA expression in normal human urothelial cells (NHUCs), UC cell lines, and formalin-fixed paraffin-embedded normal (n=6) and cancer bladder tissues (n=58) was evaluated by polymerase chain reaction (PCR) and quantitative real-time PCR (RT-PCR).	Paraffin	98-106	transient receptor potential cation channel subfamily V member 2	Homo sapiens	0-5
11425189-7	2000	We conclude that this novel chemical deglycosylation method that causes selective cleavage of distinct glycans will be useful in unmasking various mucin gene products and glycoproteins containing similar O-glycosidic linkages in the tissue sections of formalin-fixed paraffin embedded normal and pathological tissues.	Paraffin	267-275	LOC100508689	Homo sapiens	147-152
11107054-5	2000	In the three cases, a reverse transcription-polymerase chain reaction (RT-PCR) using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX1 fusion gene transcripts resulting from translocation t(X;18)(p11.2;q11.2), which is specific for synovial sarcoma.	Paraffin	133-141	synaptotagmin 1	Homo sapiens	168-171
18599112-7	2008	MVP expression was studied by immunohistochemistry in paraffin-embedded tumour tissue.	Paraffin	54-62	major vault protein	Homo sapiens	0-3
11037346-6	2000	Using double-label immunohistochemical techniques on formalin-fixed and paraffin-embedded tissues and specific antibodies directed against pituitary hormones and GnRHR, we found GnRHR immunoreactivity not only in FSH/LH cells, but also in GH- and thyroid-stimulating hormone (TSH) cells.	Paraffin	72-80	gonadotropin releasing hormone receptor	Homo sapiens	178-183
10920202-4	2000	We generated polyclonal antibodies that bind to the VASA protein in formalin-fixed, paraffin-embedded tissue and characterized VASA protein expression in human germ cells at various stages of development.	Paraffin	84-92	vasa	Drosophila melanogaster	52-56
19066503-12	2008	A unique advantage of the SMRT array is that one can use DNA isolated from formalin fixed paraffin embedded samples.	Paraffin	90-98	nuclear receptor corepressor 2	Homo sapiens	26-30
10935650-9	2000	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX2 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Paraffin	117-125	synaptotagmin 1	Homo sapiens	152-155
10935650-9	2000	In both cases, reverse transcription-polymerase chain reaction using ribonucleic acid extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX2 fusion gene transcripts, which are characteristic molecular findings of synovial sarcoma.	Paraffin	117-125	SSX family member 2	Homo sapiens	156-160
18676747-3	2008	EXPERIMENTAL DESIGN: Expression of pRb2/p130 was evaluated by immunohistochemistry on formalin-fixed, paraffin-embedded sections in 41 STSs.	Paraffin	102-110	proline rich protein BstNI subfamily 2	Homo sapiens	35-39
11314514-2	2000	METHODS: The distribution pattern of TGF-beta 1 mRNA during tooth development was analyzed on 5 microns serial sections of paraformaldehyde-fixed and paraffin-embedded embryonic mouse heads or mandibles.	Paraffin	150-158	transforming growth factor, beta 1	Mus musculus	37-47
18676747-10	2008	CONCLUSIONS: This study shows for the first time the potential prognostic value of pRb2/130 expression evaluated on formalin-fixed, paraffin-embedded sections in STSs patients.	Paraffin	132-140	proline rich protein BstNI subfamily 2	Homo sapiens	83-87
18223028-8	2008	In paraffin sections of atrial appendage tissue, we observed a distinct staining pattern for ACE2 which appeared different from that of ACE.	Paraffin	3-11	angiotensin converting enzyme 2	Homo sapiens	93-97
10867287-5	2000	On serial paraffin section, iNOS could be detected first after 3 h in the lateral wall, the supporting cells of the organ of Corti and in cells of the spiral ganglion and was observed up to 12 h. After the injection of LPS, the threshold of compound action potential became significantly worse after 12 h in the LPS group.	Paraffin	10-18	nitric oxide synthase, inducible	Cavia porcellus	28-32
18221322-6	2008	LOH in paraffin-embedded specimens was detected in 22.6% and 12.9% for FHIT and p53 respectively.	Paraffin	7-15	fragile histidine triad diadenosine triphosphatase	Homo sapiens	71-75
18469354-5	2008	We evaluated hHpr1/p84/Thoc1 expression in 133 NSCLC patients by immunohistochemistry of tissue microarrays using paraffin-embedded tumor tissue and we confirmed the tissue staining by Western blot analysis.	Paraffin	114-122	THO complex 1	Homo sapiens	13-18
10749136-6	2000	In the present study, we developed a monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues.	Paraffin	142-150	SSX family member 4	Homo sapiens	92-96
10735505-4	2000	Paraffin sections of 99 non-small-cell carcinomas were reacted with an anti-Fhit polyclonal antibody in a standard immunohistochemical reaction.	Paraffin	0-8	fragile histidine triad diadenosine triphosphatase	Homo sapiens	76-80
18303407-3	2008	We established cyclin D1 expression level in 116 frozen and formalin-fixed, paraffin-embedded primary tumors from patients diagnosed with a variety of B-cell lymphoproliferative disorders.	Paraffin	76-84	cyclin D1	Homo sapiens	15-24
18041745-6	2008	RESULTS: Using immunohistochemistry, we found that 99 of 146 paraffin-embedded GC samples expressed Bmi-1 extensively.	Paraffin	61-69	BMI1 proto-oncogene, polycomb ring finger	Homo sapiens	100-105
10594136-3	2000	The diagnosis was confirmed by demonstration of the characteristic SYT/SSX gene fusion by reverse transcriptase polymerase chain reaction (RT-PCR) performed upon RNA extracted from the paraffin block of the biopsy.	Paraffin	185-193	synaptotagmin 1	Homo sapiens	67-70
10718490-5	1999	Expression of MMP-2 protein was studied in paraffin-embedded tissue sections from primary tumors by using specific MMP-2 monoclonal antibody in an immunohistochemical staining.	Paraffin	43-51	matrix metallopeptidase 2	Homo sapiens	14-19
18197378-0	2008	Optimization of a method for the immunocytochemical detection of nestin in paraffin sections of the rat brain.	Paraffin	75-83	nestin	Rattus norvegicus	65-71
10600292-7	1999	Syndecan-1 expression was determined on paraffin-embedded tissue blocks using a human syndecan-1-specific monoclonal antibody B-B4 and immunohistochemistry.	Paraffin	40-48	syndecan 1	Homo sapiens	0-10
18197378-1	2008	The aim of the present work was to develop an optimal and simple protocol for the immunocytochemical detection of nestin (an intermediate filament protein often used as a marker for neural stem cells) in paraffin sections of the rat brain without using an antigen demasking procedure, as this distorts tissue structure.	Paraffin	204-212	nestin	Rattus norvegicus	114-120
18180112-4	2008	Paraffin-embedded tissue sections from 47 high-grade soft tissue sarcomas had previously been immunostained for CA IX and quantified using image analysis.	Paraffin	0-8	carbonic anhydrase 9	Homo sapiens	112-117
10544218-3	1999	In this study we developed monoclonal antibodies (MAbs) to CYP1B1 that are effective on formalin-fixed, paraffin-embedded tissue sections and investigated the presence of CYP1B1 in a series of primary breast cancers.	Paraffin	104-112	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	59-65
17658213-2	2007	hENT1 expression was analyzed by immunohistochemical staining in 24 NSCLC biopsy samples of formalin-fixed, paraffin-embedded tissues.	Paraffin	108-116	solute carrier family 29 member 1 (Augustine blood group)	Homo sapiens	0-5
10551739-1	1999	The expression of Fhit (fragile histidine triad) protein in oral squamous cell carcinoma (OSCC) and adjacent oral epithelium was evaluated by immunohistochemistry on formalin-fixed paraffin-embedded blocks of 32 cases of OSCC.	Paraffin	181-189	fragile histidine triad diadenosine triphosphatase	Homo sapiens	18-22
17895758-5	2007	In 48 cases, the amplification status of MDM2 and CDK4 could be evaluated with quantitative polymerase chain reaction on paraffin-embedded tissues extracted DNAs.	Paraffin	121-129	cyclin dependent kinase 4	Homo sapiens	50-54
10480344-9	1999	There was thus a strong discrepancy between results for paraffin block and fresh samples, probably because of the short life of CCND1.	Paraffin	56-64	cyclin D1	Homo sapiens	128-133
10452682-2	1999	In this study, we investigated the expression of cyclin D1 in the formalin-fixed and paraffin-embedded human hepatocellular carcinoma (HCC) tissues of 25 patients, using monoclonal antibody 5D4 raised against cyclin D1.	Paraffin	85-93	cyclin D1	Homo sapiens	49-58
18306533-2	2007	Cyclin D1 immunohistochemistry was performed on 2-4 mm thick paraffin sections using labelled streptavidin biotin kit.	Paraffin	61-69	cyclin D1	Homo sapiens	0-9
10652592-2	1999	Immunohistochemical staining for cathepsin D (clone D13A) was performed in paraffin embedded-tissues from 39 invasive squamous cell carcinomas, 13 in situ carcinomas, 35 cases of dysplasia, 10 papillomas and 17 cases of keratosis.	Paraffin	75-83	cathepsin D	Homo sapiens	33-44
17520683-3	2007	METHODS: Expression levels of CD100 in patients with localized STS were evaluated immunohistochemically on paraffin-embedded sections from 81 patients, including 47 men and 34 women with a median age of 54 years.	Paraffin	107-115	semaphorin 4D	Homo sapiens	30-35
10373649-7	1999	The aim of this study was to detect the protein expression pattern of NM23-H1 product in 24 OSCCs by immunohistochemistry in paraffin-embedded tissues using a monoclonal antibody non-cross-reactive with NM23-H2.	Paraffin	125-133	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	70-77
17125961-3	2007	METHODS: Immunohistochemical detection of Cripto was performed by using mAb C13 on 120 formalin-fixed paraffin-embedded breast tumour specimens in tissue microarrays.	Paraffin	102-110	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	42-48
12569791-2	1999	METHODS: HGV NS5 antigen was detected in paraffin-embedded HCC tissues from 53 autopsy patients by using immunohistochemical method with antiHGV NS5 monoclonal antibody.	Paraffin	41-49	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	13-16
16947015-3	2007	The specific endothelial cell marker CD 31 (PECAM) was used to immunohistochemically investigate 42 paraffin-embedded complete mid-sagittal human intervertebral disc sections of various ages (0-86 years) and varying extent of histomorphological degeneration.	Paraffin	100-108	platelet and endothelial cell adhesion molecule 1	Homo sapiens	37-42
17355452-7	2007	RESULTS: VIPR2 immunostaining was clearly positive in HPC and reactive bile ductules on paraffin-embedded and frozen tissue sections.	Paraffin	88-96	vasoactive intestinal peptide receptor 2	Homo sapiens	9-14
17493171-3	2007	The anti-CD109 antibody generated by the authors was available for formalin-fixed paraffin section, and it strongly stained myoepithelial cells and basal cells but not ductal, acinar, and secretory cells in these glands.	Paraffin	82-90	CD109 molecule	Homo sapiens	9-14
16254589-6	2007	PAX6 expression levels and patterns were analysed by Western blot analysis of total retinal protein and by immunohistochemistry on paraffin sections, respectively.	Paraffin	131-139	paired box 6	Homo sapiens	0-4
10379685-0	1999	Molecular detection of EWS-FLI1 chimeric transcripts in Ewing family tumors by nested reverse transcription-polymerase chain reaction: application to archival paraffin-embedded tumor tissues.	Paraffin	159-167	EWS RNA binding protein 1	Homo sapiens	23-26
17143956-2	2006	METHODS: Rabbit-anti-FHIT antibody was used to detect FHIT protein expression in 64 formalin-fixed, paraffin-embedded tissue specimens of inflammatory bowel disease (IBD) by citrate-microwave-streptavidin (SP)-HRP immunohistochemical method.	Paraffin	100-108	fragile histidine triad diadenosine triphosphatase	Homo sapiens	21-25
17425390-5	2007	DESIGN: Immunohistochemical staining for MUC4 was performed on formalin-fixed, paraffin-embedded tissue samples from 343 cases of NSCLC arranged in a high-density tissue microarray.	Paraffin	79-87	mucin 4, cell surface associated	Homo sapiens	41-45
10475236-6	1999	Individual antibodies of our panel recognize distinct pools of Cdk4/6, a feature reflected by their differential applicability in immunoblotting, immunoprecipitation, kinase assays, and immunostaining including immunohistochemistry on archival paraffin-embedded tissue sections.	Paraffin	244-252	cyclin dependent kinase 4	Homo sapiens	63-69
17376306-3	2007	METHODS: Fascin expression was immunohistochemically detected using monoclonal antibody against fascin in 86 paraffin embedded tissues, including 10 cases of sinonasal mucosa with chronic inflammation, 10 of EP, 45 of IP with dysplasia (45 cases were divided into three groups: IP with mild dysplasia, IP with moderate dysplasia, and IP with severe dysplasia, 15 cases each), and 21 of cancerated IP.	Paraffin	109-117	fascin actin-bundling protein 1	Homo sapiens	9-15
10084967-1	1999	We have examined the distribution of ubiquitin and the related ubiquitin cross-reactive protein (UCRP) in paraffin-embedded sections of human and baboon endometrium and decidua by immunoperoxidase or immunofluorescence cytochemistry with antibodies raised against ubiquitin, UCRP, CD45, and insulin-like growth factor-binding protein-1.	Paraffin	106-114	ISG15 ubiquitin like modifier	Homo sapiens	63-95
17345708-2	2006	METHODS: Semi-nested polymerase chain reaction ( PCR) with two pairs of primers was used to detect monoclonal IgH gene rearrangement in paraffin-embedded tissues from 11 patients with B-cell lymphoma, and one-stepped PCR with two pairs of primers was used to detect T-cell receptor gene rearrangement from 23 patients with NK/T-cell lymphoma and 20 patients with T-cell lymphoma.	Paraffin	136-144	immunoglobulin heavy constant delta	Homo sapiens	110-113
16595147-8	2006	Over-expression of PRKAA1 was further confirmed by immunohistochemical staining on 125 paraffin-embedded cervical cancer tissues.	Paraffin	87-95	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	19-25
10084967-1	1999	We have examined the distribution of ubiquitin and the related ubiquitin cross-reactive protein (UCRP) in paraffin-embedded sections of human and baboon endometrium and decidua by immunoperoxidase or immunofluorescence cytochemistry with antibodies raised against ubiquitin, UCRP, CD45, and insulin-like growth factor-binding protein-1.	Paraffin	106-114	ISG15 ubiquitin like modifier	Homo sapiens	97-101
17471153-0	2007	Molecular detection of SS18-SSX fusion gene transcripts by cRNA in situ hybridization in synovial sarcoma using formalin-fixed, paraffin-embedded tumor tissue specimens.	Paraffin	128-136	SSX family member 2	Homo sapiens	28-31
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Paraffin	104-112	fragile histidine triad diadenosine triphosphatase	Homo sapiens	186-190
16557382-5	2006	Syndecan-1 expression was assessed from formalin-fixed and paraffin-embedded tumour samples using immunohistochemistry.	Paraffin	59-67	syndecan 1	Homo sapiens	0-10
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Paraffin	104-112	fragile histidine triad diadenosine triphosphatase	Homo sapiens	253-257
17255272-6	2007	By immunohistochemical analysis, we found that 76 of 160 (47.5%) paraffin-embedded archival NPC biopsies showed high expression of CENP-H.	Paraffin	65-73	centromere protein H	Homo sapiens	131-137
16825501-0	2006	Detection of the activating JAK2 V617F mutation in paraffin-embedded trephine bone marrow biopsies of patients with chronic myeloproliferative diseases.	Paraffin	51-59	Janus kinase 2	Homo sapiens	28-32
16825501-8	2006	Thus, detection of the V617F JAK2 mutation is feasible in paraffin-embedded trephine biopsies and represents a major advance in the diagnostic evaluation of CMPD.	Paraffin	58-66	Janus kinase 2	Homo sapiens	29-33
10037284-5	1999	Immunohistochemical analysis was used to detect eIF4E on paraffin embedded sections of the tumor and the histologically negative surgical margins.	Paraffin	57-65	eukaryotic translation initiation factor 4E	Homo sapiens	48-53
10529510-9	1999	IgH gene rearrangement in formalin-fixed, paraffin-embedded specimens was determined by polymerase chain reaction in 11 patients with chronic gastritis.	Paraffin	42-50	immunoglobulin heavy locus	Homo sapiens	0-3
17951164-17	2007	The activity of cathepsin D in saliva of cystic fibrosis patient is significantly higher than in healthy controls before the stimulation of excretion with paraffin pledgets.	Paraffin	155-163	cathepsin D	Homo sapiens	16-27
23902357-3	1999	Paraffin-embedded liver sections were incubated with homologous monoclonal antibody against Atlantic salmon Vtg.	Paraffin	0-8	vitellogenin	Salmo salar	108-111
16926285-4	2006	Aberrant cytoplasmic expression of mutated NPM proteins was identified with anti-NPM antibodies in 2 or more myeloid hemopoietic cell lineages in 99 (61.5%) of 161 of NPMc+ AML paraffin-embedded bone marrow biopsies; lymphoid involvement was excluded in 3 investigated cases.	Paraffin	177-185	nucleophosmin 1	Homo sapiens	43-46
10563250-0	1999	In situ RT-PCR allows the detection of ornithine decarboxylase mRNA in paraffin embedded archival human hyperplastic breast tissues.	Paraffin	71-79	ornithine decarboxylase 1	Homo sapiens	39-62
16713333-8	2006	RCP was immunohistochemically localized in paraffin sections of liver specimens using standard methods.	Paraffin	43-51	CGRP receptor component	Homo sapiens	0-3
17149955-4	2006	EWS-FLI1 was detected by reverse transcriptase polymerase chain reaction on all 32 fresh FNAC samples and by fluorescence in situ hybridization on 16 paraffin blocks.	Paraffin	150-158	EWS RNA binding protein 1	Homo sapiens	0-3
16687090-1	2006	BACKGROUND &amp; OBJECTIVE: Clonality detection through amplifying immunoglobulin heavy chain (IgH) by polymerase chain reaction (PCR) is a useful tool in diagnosis of lymphoma, but the false negative rate is high, especially in paraffin-embedded tissues.	Paraffin	229-237	immunoglobulin heavy constant delta	Homo sapiens	67-93
16687090-1	2006	BACKGROUND &amp; OBJECTIVE: Clonality detection through amplifying immunoglobulin heavy chain (IgH) by polymerase chain reaction (PCR) is a useful tool in diagnosis of lymphoma, but the false negative rate is high, especially in paraffin-embedded tissues.	Paraffin	229-237	immunoglobulin heavy constant delta	Homo sapiens	95-98
16616093-2	2006	DESIGN: Immunohistochemical study for p16, pRb, and cyclin D1 proteins in formalin-fixed paraffin-embedded endometriotic and adenomyotic tissues.	Paraffin	89-97	cyclin D1	Homo sapiens	52-61
9827660-7	1998	As a next step, we developed a technique for TRH mRNA in situ hybridization using a [35S] CTP-labeled TRH cRNA antisense probe in formalin-fixed paraffin-embedded sections.	Paraffin	145-153	thyrotropin releasing hormone	Homo sapiens	45-48
9827660-7	1998	As a next step, we developed a technique for TRH mRNA in situ hybridization using a [35S] CTP-labeled TRH cRNA antisense probe in formalin-fixed paraffin-embedded sections.	Paraffin	145-153	thyrotropin releasing hormone	Homo sapiens	102-105
17149955-9	2006	With use of fluorescence in situ hybridization, EWS break was detected in 10 of 11 paraffin blocks used and was negative in desmoplastic small round cell tumor.	Paraffin	83-91	EWS RNA binding protein 1	Homo sapiens	48-51
9785199-3	1998	Formalin-fixed paraffin-embedded tissue was used for avidin-biotin immunocytochemical localization of IGFBPs utilizing standard methodology.	Paraffin	15-23	insulin-like growth factor binding protein 1	Mus musculus	102-108
17327058-2	2006	METHODS: The expression of lymphatic vessel endothelium markers podoplanin, VEGFR-3 and vascular endothelium marker CD31 was detected in paraffin sections from 68 cases of NSCLC and 8 cases of pulmonary inflammatory myofibroblastic tumor (PIMT) by immunohistochemistry (SP).	Paraffin	137-145	platelet and endothelial cell adhesion molecule 1	Homo sapiens	116-120
16369807-4	2006	In addition, galectin-3 expression was evaluated at the protein level by immunohistochemistry in 90 formalin-fixed paraffin-embedded cervical tissues, 10 normal cervical specimens, 20 low-grade squamous intraepithelial lesions (LSILs), 20 high-grade squamous intraepithelial lesions (HSILs), and 40 invasive squamous cell carcinomas (ISCCs).	Paraffin	115-123	galectin 3	Homo sapiens	13-23
17013093-6	2006	Expression of CDK-2 was determined immunohistochemically in formalin-fixed paraffin-embedded specimens comprising 76 lesions including 41 primary cutaneous melanomas, 15 lymph node melanoma metastases (in eight cases correlated with primary tumours), three melanoma recurrences (two cases correlated with both primary and metastatic melanomas) and 17 nevi.	Paraffin	75-83	cyclin dependent kinase 2	Homo sapiens	14-19
16438724-3	2006	METHODS: Smad4 expression was investigated by immunohistochemistry in formalin-fixed, paraffin-embedded tissue from 197 samples of primary breast cancer obtained between 1986 and 1998.	Paraffin	86-94	SMAD family member 4	Homo sapiens	9-14
9875140-5	1998	The expression of MMP-2 immunoreactive protein was studied with immunoperoxidase staining in paraffin-embedded sections of 50 cases of primary skin melanoma by using specific, affinity purified antibodies.	Paraffin	93-101	matrix metallopeptidase 2	Homo sapiens	18-23
9758365-5	1998	Immunohistochemical analysis of seprase expression in 41 formalin-fixed and paraffin-embedded specimens of human breast tissue revealed preferential immunoreactivity with the malignant cells of IDC (27 cases).	Paraffin	76-84	fibroblast activation protein alpha	Homo sapiens	32-39
17366784-3	2006	Imunohistochemistry was used to detect Smad4 and subtribes of MAPK in 71 paraffin samples.	Paraffin	73-81	SMAD family member 4	Homo sapiens	39-44
9679965-6	1998	We analyzed galectin-3 expression by immunoperoxidase staining in both paraffin-embedded cytological thyroid sediments (cell blocks) obtained by fine-needle aspiration biopsy and their histological counterparts.	Paraffin	71-79	galectin 3	Homo sapiens	12-22
9620022-5	1998	Paraffin sections of 9 reactive lymph nodes and 43 low-grade and 60 high-grade malignant lymphomas were reacted with antibodies against pRB and p16.	Paraffin	0-8	RB transcriptional corepressor 1	Homo sapiens	136-139
16428492-4	2006	EXPERIMENTAL DESIGN: PTHrP expression was assessed in paraffin-embedded tumor samples from 407 patients with NSCLC by immunohistochemistry.	Paraffin	54-62	parathyroid hormone like hormone	Homo sapiens	21-26
16820374-5	2006	Cx43 staining on paraffin-embedded kidney sections were studied by immunohistochemistry.	Paraffin	17-25	gap junction protein alpha 1	Homo sapiens	0-4
16739311-5	2006	MATERIALS AND METHOD: The protein expression of SMAD4 was evaluated immunohistochemically in 86 formalin-fixed and paraffin-embedded CRC samples.	Paraffin	115-123	SMAD family member 4	Homo sapiens	48-53
9541471-6	1998	Immunohistochemistry on formaldehyde-fixed paraffin-embedded normal human tissues revealed the presence of the class III beta-tubulin isotype in cell bodies and processes of neuronal cells in the peripheral and central nervous systems.	Paraffin	43-51	tubulin beta 3 class III	Homo sapiens	111-133
21176446-4	2006	METHODS: FHIT protein expression was detected in 298 cases of formalin fixed paraffin-embedded human samples by immunohistochemistry, including 51 precancerous lesions, 161 lung cancer samples, 30 normal lung tissue samples, 23 pulmonary benign lesion tissues and 33 metastatic lymph nodes.	Paraffin	77-85	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
16550604-5	2006	Immunohistochemical analysis of CatS expression was performed on 126 paraffin-embedded tumour samples.	Paraffin	69-77	cathepsin S	Felis catus	32-36
15876524-8	2005	Results for CD31 were higher in frozen tissue than paraffin-embedded tissue.	Paraffin	51-59	platelet and endothelial cell adhesion molecule 1	Homo sapiens	12-16
16193085-3	2005	In this study, FOXP3 protein expression has been analysed using a new anti-FOXP3 monoclonal antibody in 172 paraffin-embedded lymphoma samples.	Paraffin	108-116	forkhead box P3	Homo sapiens	15-20
9466563-0	1998	Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.	Paraffin	117-125	major vault protein	Homo sapiens	43-62
9466563-0	1998	Immunohistochemical detection of the human major vault protein LRP with two monoclonal antibodies in formalin-fixed, paraffin-embedded tissues.	Paraffin	117-125	major vault protein	Homo sapiens	63-66
9623520-5	1998	Immunohistochemical staining of paraffin sections, performed using a monoclonal antibody (9H7) against the peptide sequence 109-141 of human PTHrP, detected PTHrP in the cytoplasm and nucleoli of melanoma cells in an autopsy specimen but not in specimens from this patient prior to onset of hypercalcemia.	Paraffin	32-40	parathyroid hormone like hormone	Homo sapiens	141-146
16785796-0	2006	Development of new rabbit monoclonal antibody to progesterone receptor (Clone SP2): no heat pretreatment but effective for paraffin section immunohistochemistry.	Paraffin	123-131	progesterone receptor	Homo sapiens	49-70
9623520-5	1998	Immunohistochemical staining of paraffin sections, performed using a monoclonal antibody (9H7) against the peptide sequence 109-141 of human PTHrP, detected PTHrP in the cytoplasm and nucleoli of melanoma cells in an autopsy specimen but not in specimens from this patient prior to onset of hypercalcemia.	Paraffin	32-40	parathyroid hormone like hormone	Homo sapiens	157-162
16785796-3	2006	The authors developed the first rabbit anti-PgR mAb (clone SP2) used in IHC on formalin-fixed, paraffin-embedded tissue sections from breast carcinomas.	Paraffin	95-103	progesterone receptor	Homo sapiens	44-47
16718270-4	2006	The expression of lysosome-associated membrane protein-1 was for the first time determined immunohistochemically in formalin-fixed paraffin-embedded specimens comprising 42 primary cutaneous melanomas, 15 lymph node melanoma metastases (11 correlated with primary tumours), three melanoma recurrences (correlated with both primary and metastatic melanomas), 27 nevi and four epithelial tumours (two seborrhoeic keratoses and two basal cell carcinomas).	Paraffin	131-139	lysosomal associated membrane protein 1	Homo sapiens	18-56
9466735-2	1998	In the present study, immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements were examined by the polymerase chain reaction (PCR) in formalin-fixed and paraffin-embedded specimens obtained from 18 patients; the advantages of this method were evaluated.	Paraffin	176-184	immunoglobulin heavy constant delta	Homo sapiens	50-53
16682285-10	2006	This work helps to characterize the spectrum of mutations in the Brazilian population, and to confirm that formaldehyde-fixed paraffin tissue can provide valuable information on the RB1 status in retinoblastoma patients.	Paraffin	126-134	RB transcriptional corepressor 1	Homo sapiens	182-185
9556426-0	1998	Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases.	Paraffin	61-69	synaptotagmin 1	Homo sapiens	17-20
9556426-0	1998	Detection of the SYT-SSX chimeric RNA of synovial sarcoma in paraffin-embedded tissue and its application in problematic cases.	Paraffin	61-69	SSX family member 2	Homo sapiens	21-24
9556426-1	1998	We report the development of a reverse-transcriptase polymerase chain reaction assay that detects (in paraffin-embedded, formalin-fixed tissue) the SYT-SSXchimeric RNA transcript resulting from the t(X;18) of synovial sarcoma.	Paraffin	102-110	synaptotagmin 1	Homo sapiens	148-151
16181461-5	2005	A peptide-specific anti-RPE65 antibody was used for immunohistochemical staining of formalin-fixed and paraffin-embedded tissue sections of the respective tumours.	Paraffin	103-111	retinoid isomerohydrolase RPE65	Homo sapiens	24-29
16630058-2	2006	We examined the expression of the main p73 isoforms in adult human and mouse telencephalon and choroid plexus by immunohistochemistry on paraffin sections, and immunoblotting (IB) of tissue extracts and cerebrospinal fluid (CSF), using antibodies against different protein domains.	Paraffin	137-145	tumor protein p73	Homo sapiens	39-42
16186327-4	2005	A polymerase chain reaction (PCR) was performed on DNA extracted from vitrectomy specimens or from paraffin-embedded sections, to amplify the clonally rearranged heavy-chain immunoglobulin (IgH) genes.	Paraffin	99-107	immunoglobulin heavy locus	Homo sapiens	190-193
9349575-10	1997	Immunostaining of the corresponding formalin-fixed paraffin-embedded tissue sections detected MUC1 mucin protein at the apical domain of follicular cells.	Paraffin	51-59	mucin 1, cell surface associated	Homo sapiens	94-98
9349575-10	1997	Immunostaining of the corresponding formalin-fixed paraffin-embedded tissue sections detected MUC1 mucin protein at the apical domain of follicular cells.	Paraffin	51-59	LOC100508689	Homo sapiens	99-104
16269171-4	2006	METHODS: The expression of E7, TGF-beta1, TbetaR-II and Smad4 was detected by immunohistochemistry in paraffin-embedded cervical samples, and by RT-PCR and Western blotting in cervical cancer cell lines.	Paraffin	102-110	transforming growth factor beta receptor 2	Homo sapiens	42-51
9276186-0	1997	Obtaining clone-specific primer and probe for the immunoglobulin heavy-chain gene from paraffin-embedded tissue of B-cell lymphoma: technical considerations.	Paraffin	87-95	immunoglobulin heavy constant delta	Homo sapiens	50-76
16157025-3	2005	To apply these molecular markers to commonly available archival materials, we evaluated the feasibility of detecting EWS-Ets including EWS-Fli1 and EWS-ERG fusion transcripts in paraffin-embedded tissues and its diagnostic value for detecting ES/pPNET.	Paraffin	178-186	EWS RNA binding protein 1	Homo sapiens	117-120
16157025-16	2005	CONCLUSIONS: Molecular detection of EWS-Fli1 fusion transcripts in formalin-fixed paraffin-embedded material by nested RT-PCR is feasible and is useful for the diagnosis and differential diagnosis of ES/pPNETs.	Paraffin	82-90	EWS RNA binding protein 1	Homo sapiens	36-39
16269171-4	2006	METHODS: The expression of E7, TGF-beta1, TbetaR-II and Smad4 was detected by immunohistochemistry in paraffin-embedded cervical samples, and by RT-PCR and Western blotting in cervical cancer cell lines.	Paraffin	102-110	SMAD family member 4	Homo sapiens	56-61
16091133-5	2005	By performing immunofluorescence staining after antigen retrieval of paraffin-embedded cervical tissue samples, this study reports for the first time that connexin26 and connexin30, in addition to connexin43, are expressed in differentiating cells of normal human cervical epithelia.	Paraffin	69-77	gap junction protein beta 6	Homo sapiens	170-180
16619496-3	2006	Immunohistochemistry was used to analyze the protein expression of p53R2 in paraffin-embedded tumor samples from 130 well-characterized non-small cell lung cancer (NSCLC) patients and the expression level of p53R2, clinical variables and survival outcome were compared.	Paraffin	76-84	ribonucleotide reductase regulatory TP53 inducible subunit M2B	Homo sapiens	67-72
16061856-6	2005	In the cells isolated from paraffin-embedded tissue blocks, SP-A was deleted from 87% of the carcinoma tissues and 32% of the adjacent normal-appearing bronchial tissues.	Paraffin	27-35	surfactant protein A1	Homo sapiens	60-64
9209450-5	1997	Paraffin sections of 105 cases of ALCL were immunostained using anti-p80 antibody, and 30 of them were shown to express p80.	Paraffin	0-8	coilin	Homo sapiens	120-123
16507107-4	2006	METHODS: We studied HER-3 and HER-4 protein expression in106 paraffin embedded specimens of primary colorectal tumors using immunohistochemistry.	Paraffin	61-69	erb-b2 receptor tyrosine kinase 4	Homo sapiens	30-35
9167178-8	1997	Our data are at variance with previous mRNA studies on malignant melanoma, and indicate that routine immunohistochemical analysis for nm23 protein on paraffin-embedded tumour tissue cannot reliably be used as a prognostic marker for patients suffering from malignant melanoma.	Paraffin	150-158	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	134-138
9083560-3	1997	On paraffin sections, the Apo E immunoreactivity of diffuse plaques was weak and varied according to the method of fixation or pretreatment before immunostaining.	Paraffin	3-11	apolipoprotein E	Canis lupus familiaris	26-31
16055749-0	2005	Apolipoprotein D expression in primary brain tumors: analysis by quantitative RT-PCR in formalin-fixed, paraffin-embedded tissue.	Paraffin	104-112	apolipoprotein D	Homo sapiens	0-16
16055749-2	2005	ApoD expression was investigated by real-time quantitative RT-PCR using RNA extracted from 68 formalin-fixed, paraffin-embedded brain specimens.	Paraffin	110-118	apolipoprotein D	Homo sapiens	0-4
15732141-4	2005	To overcome this problem, an AID-specific monoclonal antibody suitable for immunohistochemical staining of formalin-fixed, paraffin wax-embedded tissue sections has been generated.	Paraffin	123-135	activation induced cytidine deaminase	Homo sapiens	29-32
16046527-6	2006	Angiogenesis was assessed by quantifying the microvessel density on CD31-stained paraffin sections and this was reduced by 60% in the PPP-treated group.	Paraffin	81-89	platelet/endothelial cell adhesion molecule 1	Mus musculus	68-72
9155651-5	1997	Weak cytoplasmic CD32 staining was observed in paraffin sections of normal lymphocytes but only when sections were microwave treated.	Paraffin	47-55	Fc gamma receptor IIa	Homo sapiens	17-21
16465772-7	2006	However, the molecular assessment of paraffin-embedded tissues revealed the monoclonal IgH gene rearrangement, which allowed the confident diagnosis of B cell lymphoma.	Paraffin	37-45	immunoglobulin heavy locus	Homo sapiens	87-90
9094461-3	1997	METHODS: Nm23 protein was detected immunohistochemically on paraffin sections using the highly sensitive labeled avidin-biotin technique.	Paraffin	60-68	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	9-13
15900369-5	2005	METHODS: We studied 35 consecutive paraffin-embedded liver tissues cases referred to Research Center for Gastroenterology and Liver Diseases, Tehran, Iran during the year 2001 to 2002 for liver biopsy due to its elevation of alanine aminotransferase (ALT) levels for more than 6 months.	Paraffin	35-43	glutamic--pyruvic transaminase	Homo sapiens	225-249
15977687-6	2005	Immunohistochemistry with pancytokeratin (AE1/AE3) was done on the paraffin sections.	Paraffin	67-75	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	42-49
16184379-4	2006	METHODS: Galectin-3 expression was investigated in paraffin sections of 35 ACC of the head and neck.	Paraffin	51-59	galectin 3	Homo sapiens	9-19
15735574-0	2005	Molecular diagnosis of synovial sarcoma: RT-PCR detection of SYT-SSX1/2 fusion transcripts in paraffin-embedded tissue.	Paraffin	94-102	synaptotagmin 1	Homo sapiens	61-69
15735574-6	2005	We also developed a method useful for RT-PCR SYT-SSX fusion transcript detection in formalin-fixed, paraffin-embedded tissue.	Paraffin	100-108	synaptotagmin 1	Homo sapiens	45-48
8908250-1	1996	Nitric oxide synthase (NOS) isoforms I and III were localized in the guinea pig cochlea by indirect immunohistochemistry using frozen sections and paraffin sections.	Paraffin	147-155	nitric oxide synthase, inducible	Cavia porcellus	0-21
8878025-0	1996	Use of CD23 (BU38) on paraffin sections in the diagnosis of small lymphocytic lymphoma and mantle cell lymphoma.	Paraffin	22-30	Fc epsilon receptor II	Homo sapiens	7-11
8878025-4	1996	We evaluated staining for the CD23 antigen in paraffin sections, using BU38, an antibody that detects a fixation-resistant epitope of the antigen.	Paraffin	46-54	Fc epsilon receptor II	Homo sapiens	30-34
17338222-0	2006	[Optimization of the immunocytochemical detection of nestin in paraffin sections of the rat brain].	Paraffin	63-71	nestin	Rattus norvegicus	53-59
8878025-13	1996	These results demonstrate that the BU38 antibody can detect CD23 on the cells of SLLs in paraffin sections and that this antibody can have diagnostic utility in routine diagnosis.	Paraffin	89-97	Fc epsilon receptor II	Homo sapiens	60-64
8623758-0	1996	Detection of the bcl-1 rearrangement at the major translocation cluster in frozen and paraffin-embedded tissues of mantle cell lymphomas by polymerase chain reaction.	Paraffin	86-94	cyclin D1	Homo sapiens	17-22
21187021-5	2005	METHODS: Expression of MRP was detected in 62 cases of paraffin-embedded NSCLC samples by streptavidin-biotin-peroxidase complex immunohistochemistry method, as well as in 30 fresh cases of NSCLC samples and corresponding normal lung tissues by immunohistochemistry and Western blot.	Paraffin	55-63	ATP binding cassette subfamily C member 3	Homo sapiens	23-26
17338222-1	2006	The aim of this study was to develop an optimal and easy protocol for immunocytochemical demonstration of nestin (an intermediate filament protein which is believed to be a neuronal stem cell marker) in paraffin sections of rat brain with target retrieval procedure being omitted for better preservation of the neural tissue structure.	Paraffin	203-211	nestin	Rattus norvegicus	106-112
15644781-6	2005	Using a polyclonal antibody to TFEB on formalin-fixed, paraffin-embedded tissue sections, we found that all 7 renal neoplasms with the t(6;11) demonstrated moderate (2 cases) or strong (5 cases) nuclear TFEB immunoreactivity.	Paraffin	55-63	transcription factor EB	Homo sapiens	31-35
16195916-4	2005	DCX expression was assessed in 69 paraffin-embedded brain tumors of neuroepithelial origin.	Paraffin	34-42	doublecortin	Homo sapiens	0-3
8857669-5	1996	Thus, MoAb MAT-1 could recognize the cells with melanogenic activity on routine formalin-fixed paraffin-embedded sections.	Paraffin	95-103	methionine adenosyltransferase 1A	Homo sapiens	11-16
8857669-7	1996	Nevertheless, MoAb MAT-1 can be expected to be very useful for identifying melanogenic cells on paraffin-embedded sections, because we have to date no other antibody available for it.	Paraffin	96-104	methionine adenosyltransferase 1A	Homo sapiens	19-24
16309203-5	2005	The expression of MMP-2 was studied immunohistochemically in paraffin-embedded tissue samples from the primary tumours by using a specific monoclonal antibody to MMP-2.	Paraffin	61-69	matrix metallopeptidase 2	Homo sapiens	18-23
8611372-3	1996	After affinity purification, the antiserum specifically detected overexpression of cyclin D1 in formalin-fixed, paraffin-embedded tumour material also.	Paraffin	112-120	cyclin D1	Homo sapiens	83-92
15619215-8	2004	Our study demonstrates the suitability of in situ hybridization with MLH1 and MSH2 probes for paraffin-embedded tissue.	Paraffin	94-102	mutS homolog 2	Homo sapiens	78-82
15586569-2	2004	The immunohistochemical pattern of E-cad expression was evaluated in formalin-fixed and paraffin-embedded sections of 6 normal mammary glands, 3 dysplasias, 12 benign tumors (8 benign mixed tumors, 4 adenomas), and 60 malignant tumors (12 stage 0, 29 stage I, 19 stage II) of the canine mammary gland.	Paraffin	88-96	cadherin 1	Canis lupus familiaris	35-40
16260273-4	2005	eIF-4E expression was evaluated by immunohistochemistry in 88 formalin-fixed, paraffin-embedded cervical tissues; 10 normal cervical specimens; 19 low-grade cervical intraepithelial neoplasias (CINs); 19 high-grade CINs; and 40 invasive squamous cell carcinomas (ISCCs).	Paraffin	78-86	eukaryotic translation initiation factor 4E	Homo sapiens	0-6
15337797-5	2004	The expression of BCL10 and NF-kappaB in pretreatment paraffin-embedded lymphoma tissues was evaluated by immunohistochemistry and confocal immunofluorescence microscopy.	Paraffin	54-62	BCL10 immune signaling adaptor	Homo sapiens	18-23
15300917-0	2004	Detection of BCL2-IGH rearrangement on paraffin-embedded tissue sections obtained from a small submucosal tumor of the rectum in a patient with recurrent follicular lymphoma.	Paraffin	39-47	immunoglobulin heavy locus	Homo sapiens	18-21
15363317-0	2004	[Detection of EWS-FLI1 fusion transcript in Ewing"s sarcoma/peripheral primitive neuroectodermal tumors by one-step RT-PCR using paraffin-embedded tissues].	Paraffin	129-137	EWS RNA binding protein 1	Homo sapiens	14-17
15363317-1	2004	OBJECTIVE: To investigate the expression of EWS-FLI1/ERG fusion transcript resulting from t(11;12)(q24;12) in paraffin-embedded tissues and its diagnostic implication for Ewing"s sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET).	Paraffin	110-118	EWS RNA binding protein 1	Homo sapiens	44-47
15363317-2	2004	METHODS: One-step reverse transcriptase-polymerase chain reaction (RT-PCR) was employed to detect a characteristic EWS-FLI1/ERG fusion transcript in 25 cases of ES/pPNET and 15 cases of other small round cell tumors (including 8 cases of rhabdomyosarcoma, 4 cases of synovial sarcoma, 2 cases of neuroblastoma and 1 case of lymphoma) using formalin-fixed and paraffin-embedded tissues.	Paraffin	359-367	EWS RNA binding protein 1	Homo sapiens	115-118
8637203-2	1996	It has been demonstrated that ER and PgR detected by immunohistochemical methods in formalin-fixed paraffin-embedded tissue can be quantified by computerized image analysis.	Paraffin	99-107	progesterone receptor	Homo sapiens	37-40
8787145-1	1996	In situ reverse transcriptase-polymerase chain reaction amplification with labeled-probe hybridization (in situ RT-PCR/LPH) was used to detect measles virus RNA within formalin-fixed, paraffin-embedded brain tissue sections from a patient who died with subacute sclerosing panencephalitis (SSPE).	Paraffin	184-192	lactase	Homo sapiens	119-122
8521382-15	1995	Our data show that: (a) immunohistochemistry may be a suitable modality to screen for RB and CDKN2/MTS1 abnormalities in paraffin-embedded tissues; (b) undetectable levels of p16 expression occur at a relatively high frequency; (c) p16 and pRB expression in common human malignancies is not mutually exclusive; (d) loss of function of both tumor suppressor genes appears to be a distinctly uncommon phenomenon; and (e) different types of carcinomas have variable rates of disturbance in the p16/pRB pathway.	Paraffin	121-129	RB transcriptional corepressor 1	Homo sapiens	86-88
16343185-1	2005	Fragile histidine triad (FHIT), a candidate of tumor suppressor protein, expression was examined on paraffin-embedded specimens in proliferative, secretory, hyperplastic, and neoplastic human endometrium by immunohistochemistry.	Paraffin	100-108	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-23
8526214-0	1995	Detection of bcl-1 gene rearrangement and B-cell clonality in mantle cell lymphoma using formalin-fixed, paraffin-embedded tissues.	Paraffin	105-113	cyclin D1	Homo sapiens	13-18
8526214-12	1995	With specialized nucleic acid isolation techniques and appropriate PCR protocol design, formalin-fixed, paraffin-embedded tissue is an adequate source of DNA for assessing MTC bcl-1 and IgH gene rearrangements.	Paraffin	104-112	cyclin D1	Homo sapiens	176-181
8522248-3	1995	METHODS: In a retrospective study of 196 patients with epithelial ovarian cancer, the amplification of the oncogenes HER-2/neu and INT-2 in the DNA of paraffin-embedded tumor cells was determined by quantitative PCR.	Paraffin	151-159	fibroblast growth factor 3	Homo sapiens	131-136
15221934-4	2004	In the present study, the expression of E2F-4 was assessed immunohistochemically on paraffin wax sections from 265 breast carcinomas and expression was compared with both clinicopathological variables and disease outcome in an attempt to identify its possible role as a TSG and to assess its prognostic value, if any, in breast cancer.	Paraffin	84-96	E2F transcription factor 4	Homo sapiens	40-45
16343185-1	2005	Fragile histidine triad (FHIT), a candidate of tumor suppressor protein, expression was examined on paraffin-embedded specimens in proliferative, secretory, hyperplastic, and neoplastic human endometrium by immunohistochemistry.	Paraffin	100-108	fragile histidine triad diadenosine triphosphatase	Homo sapiens	25-29
7490683-2	1995	Using a characterized polyclonal antiserum to UCRP, immunohistochemical localization of UCRP was performed on paraffin-processed normal human tissues and in human tissues known to contain ubiquitinated intracellular inclusions.	Paraffin	110-118	ISG15 ubiquitin like modifier	Homo sapiens	88-92
16082258-0	2005	A simple antigen retrieval method for the optimal demonstration of cyclin-D1 overexpression in formalin-fixed paraffin-embedded cases of mantle cell lymphoma.	Paraffin	110-118	cyclin D1	Homo sapiens	67-76
15571322-3	2004	Immunohistochemistry and non-radioisotopic-detected in situ hybridization were used to study protein and mRNA expression profiles for MMPs-2, -3 and -9 in paraffin sections of 70 invasive breast carcinomas.	Paraffin	155-163	matrix metallopeptidase 2	Homo sapiens	134-151
7655022-5	1995	Paraffin sections of 105 cases of ALCL were immunostained using anti-p80 antibody, and 30 of them were shown to express p80.	Paraffin	0-8	coilin	Homo sapiens	69-72
16082258-3	2005	However, demonstration of cyclin D1 by immunohistochemistry on formalin-fixed, paraffin-embedded tissue is often fraught with technical difficulties, chiefly poor staining intensity largely due to insufficient antigen retrieval.	Paraffin	79-87	cyclin D1	Homo sapiens	26-35
15151211-1	2004	We evaluated the immunohistochemical staining profile of clusterin in paraffin sections of 143 neoplasms (non-Hodgkin lymphoma, 83, including 41 anaplastic large cell lymphomas [ALCLs]; Hodgkin lymphoma, 17; primary and metastatic carcinoma, 30; and other neoplasms, 13).	Paraffin	70-78	clusterin	Homo sapiens	57-66
16244583-4	2005	PATIENTS AND METHODS: We examined the relationship between galectin-3 and cell proliferation by comparative immunostaining for galectin-3 and proliferating cell nuclear antigen (PCNA) in paraffin-embedded tissues from 126 cases of papillary thyroid carcinoma.	Paraffin	187-195	galectin 3	Homo sapiens	59-69
15111593-4	2004	The distribution of beta-galactosidase expression was analyzed in paraffin-embedded sections.	Paraffin	66-74	galactosidase beta 1	Homo sapiens	20-38
7473270-0	1995	Immunocytochemical detection of ornithine decarboxylase (ODC) in paraffin-embedded tissues as a possible prognostic indicator for oral lesions.	Paraffin	65-73	ornithine decarboxylase 1	Homo sapiens	32-55
7473270-0	1995	Immunocytochemical detection of ornithine decarboxylase (ODC) in paraffin-embedded tissues as a possible prognostic indicator for oral lesions.	Paraffin	65-73	ornithine decarboxylase 1	Homo sapiens	57-60
16155800-0	2005	A multi-centre investigation towards reaching a consensus on the immunohistochemical detection of ERbeta in archival formalin-fixed paraffin embedded human breast tissue.	Paraffin	132-140	estrogen receptor 2	Homo sapiens	98-104
7667207-3	1995	Using new antibodies makes it possible to evaluate the estrogen and progesterone receptor status in formalin-fixed and paraffin-embedded tissue.	Paraffin	119-127	progesterone receptor	Homo sapiens	68-89
7667207-5	1995	We used antibody 1D5.26 reacting with the estrogen receptor and mPR1 specific for the progesterone receptor in paraffin-embedded tissue.	Paraffin	111-119	prolactin receptor	Mus musculus	64-68
7667207-5	1995	We used antibody 1D5.26 reacting with the estrogen receptor and mPR1 specific for the progesterone receptor in paraffin-embedded tissue.	Paraffin	111-119	progesterone receptor	Homo sapiens	86-107
15054739-4	2004	METHODS: MUC4 antigens and ErbB2 receptor expression are localized by immunohistochemical studies that use archival formalin-fixed and paraffin-embedded tissue.	Paraffin	135-143	mucin 4, cell surface associated	Homo sapiens	9-13
15051038-3	2004	METHODS: MMP-1 and MMP-2 expression was investigated by immunohistochemistry from paraffin-embedded tissue in 26 patients with leiomyoma, in 24 patients with STUMP, and in 21 patients with LMS.	Paraffin	82-90	matrix metallopeptidase 2	Homo sapiens	19-24
14976524-4	2004	FHIT expression was determined by immunohistochemistry in formalin-fixed paraffin-embedded tissues from 54 squamous cell carcinomas (SCC) and 44 adenocarcinomas (AC) of the lung.	Paraffin	73-81	fragile histidine triad diadenosine triphosphatase	Homo sapiens	0-4
15013699-8	2004	This pilot study demonstrates the presence of PAH-DNA adducts in archived paraffin-embedded endoscopic esophageal biopsy samples that are close to 20 years old, and suggests that an appropriate set of archived samples could be used to prospectively correlate PAH-DNA adduct formation with risk of esophageal cancer development.	Paraffin	74-82	phenylalanine hydroxylase	Homo sapiens	46-49
15019823-6	2004	MAIN OUTCOME MEASURE(S): Paraffin-embedded endometrium was immunostained to determine the localization of MIP-3beta.	Paraffin	25-33	C-C motif chemokine ligand 19	Homo sapiens	106-115
15043312-10	2004	Positivity for JAZF1-JJAZ1 fusion transcripts was found in four of 10 fresh-frozen samples and in one of five paraffin-embedded ESTs.	Paraffin	110-118	SUZ12 polycomb repressive complex 2 subunit	Homo sapiens	21-26
14991539-5	2004	We conclude that the in situ hybridization assay for the detection of Ku70 and Ku80 expression used in this study is also suitable for tissue microarray analysis of paraffin-embedded melanoma samples.	Paraffin	165-173	X-ray repair cross complementing 5	Homo sapiens	79-83
14736821-4	2004	In situ hybridization for beta4 mRNA was performed on paraffin-embedded tissue sections of 25 invasive breast carcinomas using a hyperbiotinylated oligonucleotide DNA probe.	Paraffin	54-62	tubulin beta 3 class III	Homo sapiens	26-31
14657954-8	2004	MUC4 protein was expressed in 32 of 35 (91.4%) lung adenocarcinomas on paraffin-embedded tissue.	Paraffin	71-79	mucin 4, cell surface associated	Homo sapiens	0-4
14657954-10	2004	We conclude that MUC4 is a very specific (100%) and sensitive (91.4%) marker of lung adenocarcinomas on paraffin-embedded tissue that could be useful in diagnostic practice in the distinction between malignant mesothelioma and adenocarcinoma.	Paraffin	104-112	mucin 4, cell surface associated	Homo sapiens	17-21
14716825-2	2004	METHODS: ERbeta expression in CRC was investigated by immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections from 40 CRCs, 10 colonic adenomas, and 10 normal colon mucosa biopsies.	Paraffin	102-110	estrogen receptor 2	Homo sapiens	9-15
14555840-3	2004	The level of expression of GalNAc-T3 was analyzed immunohistochemically in paraffin-embedded tumor samples from surgically resected specimens of 59 patients with pancreatic ductal adenocarcinoma.	Paraffin	75-83	polypeptide N-acetylgalactosaminyltransferase 3	Homo sapiens	27-36
14695141-7	2003	EXPERIMENTAL DESIGN: We used immunohistochemistry to analyze the protein expression of the key initiator caspase-8 and caspase-9 in paraffin-embedded tumor samples from 77 well characterized MB patients and compared the expression levels of caspase-8 and caspase-9 with apoptosis indices, clinical variables, and survival outcomes.	Paraffin	132-140	caspase 8	Homo sapiens	105-114
14578412-4	2003	Immunohistochemistry was performed with a specific antibody for oatp-E in paraffin sections of rat eyes.	Paraffin	74-82	solute carrier organic anion transporter family, member 4a1	Rattus norvegicus	64-70
14624933-4	2003	A specific monoclonal antibody for MMP-2 was used to detect the antigen by a semiquantitative immunohistochemical staining of paraffin-embedded tissue sections.	Paraffin	126-134	matrix metallopeptidase 2	Homo sapiens	35-40
12951195-3	2003	Paraffin embedded brain sections immunoreacted with an antibody specific for phosphorylated ERKs.	Paraffin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	92-96
14506673-8	2003	The results were compared with assessment by the classic method with mouse monoclonal antibody 1A6 (PR) on paraffin sections and total agreement was observed.	Paraffin	107-115	progesterone receptor	Homo sapiens	100-102
14514922-4	2003	METHODS: The expression of Wnt2, Wnt5a, Wnt5b, Wnt7b, and Wnt10b was defined by in situ, antisense RNA hybridisation of paraffin wax embedded sections of benign naevi and malignant melanoma.	Paraffin	120-132	Wnt family member 2	Homo sapiens	27-31
12828982-5	2003	DESIGN: Paraffin-stimulated salivary samples were collected from nine pregnant women 1 month before delivery and about 2 months afterwards and assayed for salivary CA VI concentration, BC and flow rate.	Paraffin	8-16	carbonic anhydrase 6	Homo sapiens	164-169
14514379-0	2003	[Detection of cyclin D1 protein expression and t(11;14) chromosomal translocation in paraffin-embedded tissues and its clinicopathologic significance for mantle cell lymphoma].	Paraffin	85-93	cyclin D1	Homo sapiens	14-23
14514379-1	2003	OBJECTIVE: To investigate the feasibility of detecting cyclin D1 protein expression and t(11;14) chromosomal translocation in paraffin-embedded tissues and its diagnostic and differential diagnostic significance for mantle cell lymphoma (MCL).	Paraffin	126-134	cyclin D1	Homo sapiens	55-64
14514379-12	2003	CONCLUSION: The combined detection of cyclin D1 and t(11;14) in paraffin-embedded tissues is found to be a specific and feasible method for diagnosis and differential diagnosis of mantle cell lymphoma.	Paraffin	64-72	cyclin D1	Homo sapiens	38-47
12832382-5	2003	We immunostained paraffin-embedded decidual sections for a specific Th2 and Tc2 cell marker termed "chemo-attractant receptor-homologous molecule expressed on Th2 cells (CRTH2)" and T-cell markers CD3 and CD8.	Paraffin	17-25	transcobalamin 2	Homo sapiens	76-79
12820428-4	2003	PATIENTS AND METHODS: Immunohistochemical analysis of CD40 expression was performed on 59 paraffin-embedded archival tissues.	Paraffin	90-98	CD40 molecule	Homo sapiens	54-58
12684163-6	2003	RESULTS AND CONCLUSIONS: Immunohistologic localization of endothelial cells was best accomplished using anti-CD31 in Zn-fixed, paraffin-embedded tissues.	Paraffin	127-135	platelet/endothelial cell adhesion molecule 1	Mus musculus	109-113
12684163-10	2003	We conclude that anti-CD31 immunostaining in Zn-fixed, paraffin-embedded murine tissue offered superior morphology and permitted optimal identification of proliferating endothelial cells during infarct repair.	Paraffin	55-63	platelet/endothelial cell adhesion molecule 1	Mus musculus	22-26
12631600-5	2003	Immunohistochemistry for CRBP1 was performed on paraffin sections of ovarian tumors using polyclonal affinity-purified rabbit anti-CRBP1 antibody.	Paraffin	48-56	retinol binding protein 1	Homo sapiens	25-30
12527925-3	2003	And to evaluate the biological significance, immunohistochemical expression of PAR-2 in malignant and non-malignant human pancreatic tissues was examined using paraffin-embedded sections.	Paraffin	160-168	F2R like trypsin receptor 1	Homo sapiens	79-84
12527925-4	2003	The presence of PAR-2 was confirmed in all 5 pancreatic cancer cell lines and all 21 paraffin-embedded specimens from human pancreatic cancer examined.	Paraffin	85-93	F2R like trypsin receptor 1	Homo sapiens	16-21
12473599-10	2002	This study demonstrates for the first time the potential independent prognostic value of pRb2/p130 expression on formalin-fixed, paraffin-embedded sections from lung cancer patients.	Paraffin	129-137	proline rich protein BstNI subfamily 2	Homo sapiens	89-93
12404291-4	2002	METHODS: The authors assessed the immunohistochemical expression of VEGF and metalloproteinases MMP-2 and MMP-9 in paraffin embedded biopsy specimens of malignant melanomas (18 invasive melanomas and 10 in situ melanomas); dysplastic nevi with architectural disorder and cytologic atypia of melanocytes; Spitz nevi; and compound or predominantly intradermal, ordinary, benign melanocytic nevi.	Paraffin	115-123	matrix metallopeptidase 2	Homo sapiens	96-101
12376514-6	2002	We measured cyclin D1 status in paraffin-embedded, archived tissue from 78.8% of the breast cancer cases using immunohistochemistry.	Paraffin	32-40	cyclin D1	Homo sapiens	12-21
12370115-4	2002	METHODS: We retrospectively analysed galectin-3 expression by immunoperoxidase staining on 32 cytological paraffin-embedded samples of cystic papillary carcinoma and on 12 samples of benign cysts, both obtained by FNA biopsy.	Paraffin	106-114	galectin 3	Homo sapiens	37-47
12354182-2	2002	ERalpha was visualized by immunohistochemistry on paraffin sections of ovaries obtained from 11 non-pregnant and 2 pregnant animals.	Paraffin	50-58	estrogen receptor 1	Bos taurus	0-7
7540362-3	1995	In a previous study, the authors demonstrated expression of cyclin D1 in 15 of 15 cases of mantle cell lymphoma and 1 of 8 cases of B-chronic lymphocytic leukemia (B-CLL) using a polyclonal antibody and microwave enhanced immunohistochemical staining method on paraffin-embedded tissue sections.	Paraffin	261-269	cyclin D1	Homo sapiens	60-69
7752392-10	1995	Loss of RB immunohistochemical staining in paraffin-embedded tissue was detected in none of the primary tumors (0 of 30) or metastatic tumors (0 of 12).	Paraffin	43-51	RB transcriptional corepressor 1	Homo sapiens	8-10
7675778-11	1995	Nuclear cyclin D1 protein can be detected in approximately one-third of infiltrating breast carcinomas using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue.	Paraffin	161-169	cyclin D1	Homo sapiens	8-17
7750083-4	1995	It offers the advantages of retrospectively determining the amount of ODC in samples previously embedded in paraffin.	Paraffin	108-116	ornithine decarboxylase 1	Homo sapiens	70-73
7567941-0	1995	Keratin 19 in paraffin sections of medullary carcinoma and other benign and malignant breast lesions.	Paraffin	14-22	keratin 19	Homo sapiens	0-10
7612496-3	1995	PATIENTS AND METHODS: To assess the utility of in situ hybridization (ISH) to detect cyclin D1 mRNA expression in formalin-fixed, paraffin embedded tissue, five MCL specimens from three patients and two cases of B-cell small lymphocytic lymphoma (B-SLL) were studied.	Paraffin	130-138	cyclin D1	Homo sapiens	85-94
7612496-9	1995	CONCLUSIONS: Overexpression of cyclin D1 mRNA can be detected in MCL by ISH using formalin fixed paraffin embedded tissue.	Paraffin	97-105	cyclin D1	Homo sapiens	31-40
7861542-2	1995	Paraffin sections were immunostained with either anti-GLUT1 or GLUT4 antibody by the avidin-biotin-peroxidase complex method.	Paraffin	0-8	solute carrier family 2 member 4	Homo sapiens	63-68
8088760-0	1994	Cathepsin D immunostaining in paraffin-embedded breast cancer cells and macrophages: correlation with cytosolic assay.	Paraffin	30-38	cathepsin D	Homo sapiens	0-11
8004587-2	1994	METHODS: Using a polyclonal serum to the 37-67 region of PTHrP, and 35S-labeled riboprobes, the authors investigated the cellular expression of PTHrP mRNA and peptide in formalin fixed, paraffin embedded sections from 16 invasive cervical tumors.	Paraffin	186-194	parathyroid hormone like hormone	Homo sapiens	144-149
8058716-0	1994	Progesterone receptor detection in paraffin sections of human breast cancers by an immunoperoxidase technique incorporating microwave heating.	Paraffin	35-43	progesterone receptor	Homo sapiens	0-21
8058716-1	1994	We sought to establish an easily interpretable and highly sensitive immunohistochemical method for detecting progesterone receptor protein in formalin-fixed, paraffin-embedded samples of breast carcinomas.	Paraffin	158-166	progesterone receptor	Homo sapiens	109-130
8144142-1	1994	Archival material from 47 primary invasive adenocarcinomas of the uterine cervix was examined using an immunocytochemical technique for detection of oestrogen receptor and progesterone receptor in paraffin-wax embedded tissues.	Paraffin	197-209	progesterone receptor	Homo sapiens	172-193
7931823-2	1994	NCL-DK4 has been proved to be highly effective for use on formalin-fixed, paraffin-embedded tissues, enabling the study of c-jun expression at a cellular level in both normal and neoplastic human tissues.	Paraffin	74-82	nucleolin	Homo sapiens	0-3
8007456-2	1993	IL-5 cDNA probes were labeled with digoxigenin-dUTP and hybridized to frozen or paraffin tissue sections.	Paraffin	80-88	interleukin 5	Homo sapiens	0-4
7693339-10	1993	Moreover, paraffin-embedded sections of primary tumors from human osteosarcomas, chondrosarcomas, and leiomyosarcoma stain intensely for Met and/or HGF/SF and display extensive tumor cell heterogeneity with regard to both paracrine and autocrine stimulation.	Paraffin	10-18	hepatocyte growth factor	Homo sapiens	148-154
8168154-2	1993	With this technique, we have been able to detect expression of J chain and mu chain in a single 6-10-microns-thick formalin-fixed paraffin-embedded section of fetal liver tissue.	Paraffin	130-138	joining chain of multimeric IgA and IgM	Homo sapiens	63-83
8514608-6	1993	Immunohistochemical study, using paraffin-embedded sections of the tumor tissue obtained at autopsy, revealed numerous PTHrP-positive cells and expression of PTHrP gene was confirmed by Northern blot analysis.	Paraffin	33-41	parathyroid hormone like hormone	Homo sapiens	119-124
8104720-1	1993	A monoclonal antibody, NCL-CB11, raised against a synthetic peptide from the predicted sequence of the c-erbB-2 protein has been used immunohistochemically in a retrospective study of formalin-fixed paraffin embedded breast neoplasm biopsies.	Paraffin	199-207	nucleolin	Homo sapiens	23-26
8392481-1	1993	We present a new application of an immunocytochemical technique on central nervous tissue which utilizes Golgi-Cox impregnated paraffin embedded material.	Paraffin	127-135	cytochrome c oxidase subunit 8A	Homo sapiens	111-114
8470339-9	1993	For the retrospective examination of paraffin-embedded material, the detection of vWF and GP IIIa appears to be the most reliable method for the identification of megakaryocytic cells.	Paraffin	37-45	von Willebrand factor	Canis lupus familiaris	82-85
8105839-0	1993	HER-2 and INT-2 amplification estimated by quantitative PCR in paraffin-embedded ovarian cancer tissue samples.	Paraffin	63-71	fibroblast growth factor 3	Homo sapiens	10-15
8105839-1	1993	Competitive polymerase chain reaction (PCR) systems were developed for rapid and quantitative estimation of HER-2 (c-erbB-2) and INT-2 oncogene amplification in paraffin-embedded ovarian cancer tissue samples.	Paraffin	161-169	fibroblast growth factor 3	Homo sapiens	129-134
1325266-3	1992	METHODS: The expression of TGF-alpha and its relation to the HBV antigens were evaluated in human HCC and adjacent nontumorous livers from 33 patients from the United States and China using immunoperoxidase staining of paraffin-embedded sections.	Paraffin	219-227	transforming growth factor alpha	Homo sapiens	27-36
1322859-2	1992	We applied immunohistochemistry using the avidin-biotin-peroxidase technique to localize PLP in formalin-fixed, paraffin-embedded tissues of two human pancreatic carcinomas associated with hypercalcemia and normal blood parathyroid hormone levels.	Paraffin	112-120	parathyroid hormone like hormone	Homo sapiens	89-92
1636730-2	1992	Immunoperoxidase studies of formaldehyde solution-fixed and paraffin-embedded rat lung demonstrated staining for SP-D in the cytoplasm of a subpopulation of bronchiolar epithelial cells as well as type II cells.	Paraffin	60-68	surfactant protein D	Rattus norvegicus	113-117
1592525-2	1992	Strong statistical validation was obtained in the use of BrE-3 in immunohistochemical procedures where scores for the expression of the mucin on paraffin-embedded sections of the primary breast tumors were studied.	Paraffin	145-153	LOC100508689	Homo sapiens	136-141
1374774-1	1992	Periodate pretreatment of paraffin sections of ethanol-fixed gastrointestinal mucosae was used to characterize the carbohydrate or peptidic nature of mucin epitopes by immunoperoxidase.	Paraffin	26-34	LOC100508689	Homo sapiens	150-155
12452072-3	2002	METHODS: Fhit protein expression in 66 cases of formalin-fixed, paraffin-embedded breast cancer composed of 6 in situ and 60 invasive ductal carcinoma were detected with citrate-microwave-Streptavidin-HRP(SP) immunohistochemical method, using rabbit antibody to human FHIT gene protein and relationships to invasion and lymphatic metastasis were analyzed.	Paraffin	64-72	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
16383299-0	2005	[Detection of cyclin D1 mRNA by reverse transcription-polymerase chain reaction in paraffin-embedded tissues and its diagnostic significance for mantle cell lymphoma].	Paraffin	83-91	cyclin D1	Homo sapiens	14-23
12037384-2	2002	Staining of paraffin sections from allergic and nonallergic patients revealed nNOS immunoreactivity (nNOS-IR) in the muscular layer of vessels, in the basal portion of submucosal glands and in the periost and the osteocytes of the turbinate bones.	Paraffin	12-20	nitric oxide synthase 1	Homo sapiens	78-82
1377856-4	1992	As shown in preparations of human retina and pineal organ, IRBP can be successfully demonstrated in formalin-fixed and paraffin-embedded tissue: the IRBP immunoreaction is located to the outer and inner segments of retinal photoreceptor cells and to perikarya of certain pinealocytes.	Paraffin	119-127	retinol binding protein 3	Homo sapiens	59-63
1377856-4	1992	As shown in preparations of human retina and pineal organ, IRBP can be successfully demonstrated in formalin-fixed and paraffin-embedded tissue: the IRBP immunoreaction is located to the outer and inner segments of retinal photoreceptor cells and to perikarya of certain pinealocytes.	Paraffin	119-127	retinol binding protein 3	Homo sapiens	149-153
12037384-2	2002	Staining of paraffin sections from allergic and nonallergic patients revealed nNOS immunoreactivity (nNOS-IR) in the muscular layer of vessels, in the basal portion of submucosal glands and in the periost and the osteocytes of the turbinate bones.	Paraffin	12-20	nitric oxide synthase 1	Homo sapiens	101-105
16383299-1	2005	OBJECTIVE: To investigate the feasibility of detecting cyclin D1 mRNA in paraffin-embedded tissues by reverse transcriptase polymerase chain reaction (RT-PCR) and competitive RT-PCR and its diagnostic and differential diagnostic significance for mantle cell lymphoma (MCL).	Paraffin	73-81	cyclin D1	Homo sapiens	55-64
1327036-1	1992	We examined expression of the major surfactant-associated protein SP-A, a product characteristic of type II pneumocytes, in a panel of 126 non-small-cell lung carcinomas (NSCLC) by immunohistochemistry using routine paraffin-embedded material.	Paraffin	216-224	surfactant protein A1	Homo sapiens	66-70
16383299-8	2005	(3) cyclin D1 mRNA was detected in 34 nodal mantle cell lymphoma cases by RT-PCR in paraffin-embedded tissues.	Paraffin	84-92	cyclin D1	Homo sapiens	4-13
16383299-12	2005	(4) Cyclin D1 mRNA overexpression was detected in 27 cases of nodal mantle cell lymphoma by competitive RT-PCR in paraffin-embedded tissues.	Paraffin	114-122	cyclin D1	Homo sapiens	4-13
11900573-5	2002	DESIGN: Cyclin D1 immunohistochemical analysis was used to evaluate 108 fixed, paraffin-embedded endometrial biopsy specimens and uterine resections obtained from 108 patients.	Paraffin	79-87	cyclin D1	Homo sapiens	8-17
16383299-15	2005	CONCLUSION: RT-PCR and competitive RT-PCR detection of cyclin D1 mRNA overexpression could be used for the diagnosis and differential diagnosis of mantle cell lymphoma in paraffin-embedded blocks.	Paraffin	171-179	cyclin D1	Homo sapiens	55-64
15910293-2	2005	CXCR3 expression was localized in formalin-fixed, paraffin-embedded renal allograft biopsies without signs of rejection (C4d-negative, Banff 0, n = 16), with C4d deposits as a sign of humoral rejection (C4d-positive, Banff 0, n = 8), with cellular rejection (C4d-negative, Banff I, n = 7) and with signs of both cellular and humoral rejection (C4d-positive, Banff 1, n = 5).	Paraffin	50-58	C-X-C motif chemokine receptor 3	Homo sapiens	0-5
11932895-4	2002	METHODS: The expression of GalNAc-T3 was evaluated immunohistochemically in 106 paraffin embedded samples from surgically resected colorectal carcinomas and was related to patient and tumor characteristics.	Paraffin	80-88	polypeptide N-acetylgalactosaminyltransferase 3	Homo sapiens	27-36
1744798-0	1991	CD23 expression in non-Hodgkin lymphoma: immunohistochemical demonstration using the antibody BU38 on paraffin sections.	Paraffin	102-110	Fc epsilon receptor II	Homo sapiens	0-4
1656005-0	1991	Immunohistochemical determination of CD23 expression in Hodgkin"s disease using paraffin sections.	Paraffin	80-88	Fc epsilon receptor II	Homo sapiens	37-41
16335684-8	2005	Immunohistochemical staining for Tg was performed on formalin-fixed, paraffin-embedded sections with anti-Tg antibodies.	Paraffin	69-77	thyroglobulin	Homo sapiens	33-35
1827636-2	1991	The expression of CD23 on the surface of lymphocytes in paraffin wax sections of synovial biopsy specimens was studied using a novel mouse monoclonal antibody, BU38.	Paraffin	56-68	Fc epsilon receptor II	Homo sapiens	18-22
12325398-10	2002	Our results confirmed that the immunodetection of the PgR and Ki-67 antigens on the paraffin sections of meningiomas provides a valuable tool for estimating the biological behavior of meningiomas.	Paraffin	84-92	progesterone receptor	Homo sapiens	54-57
11920593-5	2002	Immunoreactivity for monoclonal anti-cyclinD1 antibody (clone DCS-6) with paraffin-embedded carcinoma tissues was investigated using a labeled streptavidin-biotin method.	Paraffin	74-82	cyclin D1	Homo sapiens	37-45
15735172-4	2005	METHODS: Runx2/Cbfa1 and NFkappaB (p65) immunoreactivity was assessed on 11 paraffin wax embedded archival specimens of human primary osteosarcoma by standard immunohistochemical methods and scored on a scale of 0-3.	Paraffin	76-88	RELA proto-oncogene, NF-kB subunit	Homo sapiens	35-38
12479060-6	2002	RESULTS: The positive rate of Smad4, p21wafI, and p16 in paraffin embedded human pancreatic cancer tissue was 58.93%, 48.21%, and 42.86%, respectively, whereas the positive rate of these proteins in matched normal tissue was 89.29%, 87.5%, and 76.79% respectively.	Paraffin	57-65	SMAD family member 4	Homo sapiens	30-35
15689315-0	2005	[Analysis of immunoglobulin heavy chain genes rearrangement by PCR from paraffin-embedded tissue in B-cell lymphomes in Tunisia].	Paraffin	72-80	immunoglobulin heavy constant delta	Homo sapiens	13-39
11774187-9	2001	CONCLUSION: When HH is clinically and/or histologically suspected, HFE gene sequencing of formalin-fixed, paraffin-embedded liver biopsy specimens is a rapid and cost-effective approach to genotypic diagnosis of HH.	Paraffin	106-114	homeostatic iron regulator	Homo sapiens	67-70
1872731-8	1991	The use of a polyclonal rabbit anti-MG2 reagent in either frozen or paraffin-embedded tissues gave the same immunocytochemical results as those obtained with the monoclonal antibody.	Paraffin	68-76	mucin 7, secreted	Homo sapiens	36-39
15634444-0	2004	[Detection of ASPL-TFE3 fusion gene by reverse transcriptase polymerase chain reaction in paraffin-embedded tumor tissues of alveolar soft part sarcoma].	Paraffin	90-98	transcription factor binding to IGHM enhancer 3	Homo sapiens	19-23
1821419-5	1991	The mAB A53-B/A2 (CK19) stained selectively the folliculo-stellate cells in frozen and paraffin sections.	Paraffin	87-95	keratin 19	Homo sapiens	18-22
11866984-13	2001	CONCLUSIONS: (1) Detection of SYT-SSX fusion gene in paraffin-embedded tissues was found to be a sensitive and specific method for the diagnosis and differential diagnosis of synovial sarcoma.	Paraffin	53-61	SSX family member 2	Homo sapiens	34-37
11866985-1	2001	OBJECTIVE: To demonstrate that a characteristic SYT-SSX fusion gene resulting from chromosomal translocation t (X; 18) (p11; q11) was detectable in archival paraffin-embedded synovial sarcoma tissues.	Paraffin	157-165	synaptotagmin 1	Homo sapiens	48-51
11866985-1	2001	OBJECTIVE: To demonstrate that a characteristic SYT-SSX fusion gene resulting from chromosomal translocation t (X; 18) (p11; q11) was detectable in archival paraffin-embedded synovial sarcoma tissues.	Paraffin	157-165	SSX family member 2	Homo sapiens	52-55
11866987-2	2001	METHODS: The expression of Smad4, TGF beta1 and TbetaR II in paraffin embedded pancreatic carcinoma tissues was detected by using antibodies against Smad4, TGF beta1 and TbetaR II with EnVision immunohistochemistry.	Paraffin	61-69	SMAD family member 4	Homo sapiens	27-32
11866987-2	2001	METHODS: The expression of Smad4, TGF beta1 and TbetaR II in paraffin embedded pancreatic carcinoma tissues was detected by using antibodies against Smad4, TGF beta1 and TbetaR II with EnVision immunohistochemistry.	Paraffin	61-69	transforming growth factor beta receptor 2	Homo sapiens	48-57
11866987-2	2001	METHODS: The expression of Smad4, TGF beta1 and TbetaR II in paraffin embedded pancreatic carcinoma tissues was detected by using antibodies against Smad4, TGF beta1 and TbetaR II with EnVision immunohistochemistry.	Paraffin	61-69	SMAD family member 4	Homo sapiens	149-154
11866987-2	2001	METHODS: The expression of Smad4, TGF beta1 and TbetaR II in paraffin embedded pancreatic carcinoma tissues was detected by using antibodies against Smad4, TGF beta1 and TbetaR II with EnVision immunohistochemistry.	Paraffin	61-69	transforming growth factor beta receptor 2	Homo sapiens	170-179
2250189-1	1990	An avidin-biotin enhanced immunoperoxidase procedure using monoclonal antibodies (AA1, AA3, and AA5) prepared against human mast cell tryptase resulted in intense staining of mast cells in paraffin-embedded tissue.	Paraffin	189-197	AA1	Homo sapiens	82-85
15634444-9	2004	CONCLUSIONS: The expression of ASPL-TFE3 fusion transcripts in paraffin-embedded tumor tissues can serve as an useful molecular marker in the diagnosis of ASPS.	Paraffin	63-71	transcription factor binding to IGHM enhancer 3	Homo sapiens	36-40
15466169-4	2004	We have now screened for breaks at NRG1 in paraffin sections of breast tumors.	Paraffin	43-51	neuregulin 1	Homo sapiens	35-39
1975165-1	1990	The purpose of this report is to assess whether phenotyping by three monoclonal antibodies routinely used in paraffin sections (Ber-H2-Leu-M1-EMA) and shown to be the most useful for diagnosis may be a predictive factor for recurrences.	Paraffin	109-117	mucin 1, cell surface associated	Homo sapiens	142-145
2171484-4	1990	Several applications of the polymerase chain reaction for B19 DNA detection are discussed: i) Detection of B19 DNA sequences in paraffin-embedded fetal tissues in a case of intrauterine fetal death; ii) The presence of B19 DNA in a case of B19 infection after a bone marrow transplantation was demonstrated for a longer period of time as compared to detection with dot-hybridization; iii) In a considerable number of sera, proven to be B19 specific IgM positive, the presence of B19 DNA was demonstrated.	Paraffin	128-136	eva-1 homolog C	Homo sapiens	58-61
15325567-2	2004	Toll-like receptor-4 and CD14 proteins were detected by immunohistochemical analysis of sections of whole human eyes embedded in paraffin with monoclonal antibodies against human toll-like receptor-4 (HTA-125), human CD14 (RPA-M1), or as a control, an irrelevant mouse IgG1k (MOPC-21).	Paraffin	129-137	CD14 molecule	Homo sapiens	25-29
2171484-4	1990	Several applications of the polymerase chain reaction for B19 DNA detection are discussed: i) Detection of B19 DNA sequences in paraffin-embedded fetal tissues in a case of intrauterine fetal death; ii) The presence of B19 DNA in a case of B19 infection after a bone marrow transplantation was demonstrated for a longer period of time as compared to detection with dot-hybridization; iii) In a considerable number of sera, proven to be B19 specific IgM positive, the presence of B19 DNA was demonstrated.	Paraffin	128-136	eva-1 homolog C	Homo sapiens	107-110
2171484-4	1990	Several applications of the polymerase chain reaction for B19 DNA detection are discussed: i) Detection of B19 DNA sequences in paraffin-embedded fetal tissues in a case of intrauterine fetal death; ii) The presence of B19 DNA in a case of B19 infection after a bone marrow transplantation was demonstrated for a longer period of time as compared to detection with dot-hybridization; iii) In a considerable number of sera, proven to be B19 specific IgM positive, the presence of B19 DNA was demonstrated.	Paraffin	128-136	eva-1 homolog C	Homo sapiens	107-110
2171484-4	1990	Several applications of the polymerase chain reaction for B19 DNA detection are discussed: i) Detection of B19 DNA sequences in paraffin-embedded fetal tissues in a case of intrauterine fetal death; ii) The presence of B19 DNA in a case of B19 infection after a bone marrow transplantation was demonstrated for a longer period of time as compared to detection with dot-hybridization; iii) In a considerable number of sera, proven to be B19 specific IgM positive, the presence of B19 DNA was demonstrated.	Paraffin	128-136	eva-1 homolog C	Homo sapiens	107-110
2171484-4	1990	Several applications of the polymerase chain reaction for B19 DNA detection are discussed: i) Detection of B19 DNA sequences in paraffin-embedded fetal tissues in a case of intrauterine fetal death; ii) The presence of B19 DNA in a case of B19 infection after a bone marrow transplantation was demonstrated for a longer period of time as compared to detection with dot-hybridization; iii) In a considerable number of sera, proven to be B19 specific IgM positive, the presence of B19 DNA was demonstrated.	Paraffin	128-136	eva-1 homolog C	Homo sapiens	107-110
11520144-2	2001	METHODS: EMA immunostaining was performed in 178 paraffin-embedded specimens including 105 endometrial cancers, 40 endometrial hyperplasias, and 33 benign endometriums.	Paraffin	49-57	mucin 1, cell surface associated	Homo sapiens	9-12
11680983-3	2001	Immunoglobulin heavy chain gene rearrangement was detected by polymerase chain reaction using third-complementary-determining region (CDR 3) specific primers in BM mononuclear cells and spleen cells embedded in paraffin.	Paraffin	211-219	CDR3	Homo sapiens	134-139
15284539-5	2004	METHODS: MUC4 and ErbB2 receptor expression was localized by immunohistochemical studies using archival formalin-fixed and paraffin-embedded tissue.	Paraffin	123-131	mucin 4, cell surface associated	Homo sapiens	9-13
2139890-0	1990	Immunohistochemical determination of CD23 expression in Hodgkin"s disease using paraffin sections.	Paraffin	80-88	Fc epsilon receptor II	Homo sapiens	37-41
2139890-2	1990	We studied the expression of CD23 in paraffin sections of lymphoid tissue using the monoclonal antibody BU38.	Paraffin	37-45	Fc epsilon receptor II	Homo sapiens	29-33
15543376-3	2004	The immunoexpression of the pan-cytokeratin AE1AE3 was studied in paraffin-embedded tissue sections from 24 Wilms" tumors (12 with nephrogenic rests) and also tissue samples from 15 corresponding normal kidneys, to evaluate epithelial differentiation in the genesis of Wilms" tumor.	Paraffin	66-74	adenosine deaminase 2	Homo sapiens	28-31
1739138-3	1992	The authors used an indirect immunofluorescent technique to localize eosinophil granule major basic protein (MBP) in formalin-fixed, paraffin-embedded tissue specimens from 50 patients.	Paraffin	133-141	proteoglycan 2, pro eosinophil major basic protein	Homo sapiens	69-107
1739138-3	1992	The authors used an indirect immunofluorescent technique to localize eosinophil granule major basic protein (MBP) in formalin-fixed, paraffin-embedded tissue specimens from 50 patients.	Paraffin	133-141	myelin basic protein	Homo sapiens	109-112
11479017-4	2001	Paraffin embedded brain sections immunoreacted with an antibody selective for the phosphorylated erks.	Paraffin	0-8	mitogen activated protein kinase 3	Rattus norvegicus	97-101
11351307-3	2001	In the present study, a method for the immunochemical detection of NY-ESO-1 in paraffin-embedded tissues has been developed and used to define the expression pattern of NY-ESO-1 in normal tissues and in a panel of human tumors.	Paraffin	79-87	cancer/testis antigen 1A	Homo sapiens	67-75
34627038-8	2021	Moreover, there was a clear increase in signal intensity for paraffin sections when an AR step was performed compared to condition without AR.	Paraffin	61-69	ferredoxin reductase	Mus musculus	87-89
15084384-4	2004	Immunohistochemical investigation of paraffin sections of 44 SCLC and 40 NSCLC tumors revealed recoverin-positive reaction in 30 SCLC (68%) and 34 NSCLC (85%) sections.	Paraffin	37-45	recoverin	Homo sapiens	95-104
34308375-4	2021	Here we describe an optimized protocol for immunostaining of ACE2 in formalin fixed paraffin embedded human (FFPE) pancreas, small intestine and kidney tissue sections obtained from organ donors and autopsies.	Paraffin	84-92	angiotensin converting enzyme 2	Homo sapiens	61-65
11335900-7	2001	The expression of Skp2 also was examined by immunohistochemistry using formalin fixed, paraffin embedded tissue sections from the same cases.	Paraffin	87-95	S-phase kinase associated protein 2	Homo sapiens	18-22
15102689-5	2004	Immunohistochemistry analysis for FAK was performed on paraffin-embedded tissues.	Paraffin	55-63	protein tyrosine kinase 2	Homo sapiens	34-37
34188154-5	2021	We validated ACE2 protein expression and localization in formalin-fixed, paraffin-embedded matched colon and ileal tissues using immunohistochemistry.	Paraffin	73-81	angiotensin converting enzyme 2	Homo sapiens	13-17
11358058-0	2001	The application of a PCR technique for the detection of immunoglobulin heavy chain gene rearrangements in fresh or paraffin-embedded skin tissue.	Paraffin	115-123	immunoglobulin heavy constant delta	Homo sapiens	56-82
15024701-4	2004	The potential importance of overproduction of protein products in neoplastic development, led us also to study a possible high expression of cdk4, mdm2 and gli proteins in immunohistochemical staining experiments on paraffin-embedded tissue samples of the same cases.	Paraffin	216-224	cyclin dependent kinase 4	Homo sapiens	141-145
11358058-2	2001	Having refined a PCR technique for the detection of immunoglobulin heavy chain (IgH) gene rearrangement in both fresh and formalin-fixed, paraffin-embedded skin samples, we undertook to define the role of this assay in the diagnostic setting.	Paraffin	138-146	immunoglobulin heavy constant delta	Homo sapiens	52-78
11358058-2	2001	Having refined a PCR technique for the detection of immunoglobulin heavy chain (IgH) gene rearrangement in both fresh and formalin-fixed, paraffin-embedded skin samples, we undertook to define the role of this assay in the diagnostic setting.	Paraffin	138-146	immunoglobulin heavy constant delta	Homo sapiens	80-83
11422798-6	2001	The SYT-SSX2 fusion transcripts were detected by a reverse transcription-polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissue.	Paraffin	149-157	synaptotagmin 1	Homo sapiens	4-7
11422798-6	2001	The SYT-SSX2 fusion transcripts were detected by a reverse transcription-polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissue.	Paraffin	149-157	SSX family member 2	Homo sapiens	8-12
11277266-6	2001	Demethylation of the CpG loci around the Spl binding site was shown in cases with high BMP-6 expression by sequencing analysis of the methylated cytosine from paraffin-embedded materials.	Paraffin	159-167	sphingosine-1-phosphate lyase 1	Homo sapiens	41-44
34168109-3	2021	The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.	Paraffin	53-61	prostaglandin D2 receptor	Homo sapiens	10-13
35468339-5	2022	Accordingly, in the present study, we aimed to reveal the clinical significance of miR-130a, miR-301a, miR-454 expression levels in formalin fixed paraffin embedded (FFPE) tissue samples of prostate cancer patients.	Paraffin	147-155	microRNA 130a	Homo sapiens	83-91
15190803-2	2004	METHODS: Expression of P16 and nm23 proteins was examined by SABC immunohistochemical method in 39 cases of paraffin blocks of normal salivary gland tissues and salivary gland tumors.	Paraffin	108-116	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	31-35
35586706-3	2022	Expression of a three-gene signature (IGFBP3, F3, VGLL3) was measured in formalin-fixed paraffin-embedded material from diagnostic core needle biopsies (CNB) of these patients.	Paraffin	88-96	vestigial like family member 3	Homo sapiens	50-55
11812324-2	2001	METHODS: The distribution pattern of TGF-beta 1 mRNA was analysed on 5 microns serial sections of paraformaldehyde-fixed and paraffin-embedded embryonic mouse heads or mandibles using in situ hybridization.	Paraffin	125-133	transforming growth factor, beta 1	Mus musculus	37-47
14747034-0	2004	Efficient treatment of paraffin-embedded cervical tissue for HPV DNA testing by HC-II and PCR assays.	Paraffin	23-31	serpin family D member 1	Homo sapiens	80-85
11159207-0	2001	API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.	Paraffin	134-142	MALT1 paracaspase	Homo sapiens	5-10
35137520-4	2022	Immunohistochemistry(IHC) was used to evaluate the protein expression level of TUSC3 in four paired specimens, 220 paraffin-embedded CSCC specimens and 60 cases of normal cervical tissues(NCTs), respectively.	Paraffin	115-123	tumor suppressor candidate 3	Homo sapiens	79-84
14747034-3	2004	STUDY DESIGN: the use of HC-II assay with formaldehyde-fixed paraffin-embedded cervical biopsies, for retrospective studies or to support histological findings, was investigated by analysing three different sample treatments.	Paraffin	61-69	serpin family D member 1	Homo sapiens	25-30
11235907-0	2001	In situ hybridization and reverse transcription-polymerase chain reaction for cyclin D1 mRNA in the diagnosis of mantle cell lymphoma in paraffin-embedded tissues.	Paraffin	137-145	cyclin D1	Homo sapiens	78-87
11235907-11	2001	In conclusion, stringent RT-PCR for cyclin D1 expression can be helpful in MCL diagnosis in paraffin-embedded material from lymph nodes.	Paraffin	92-100	cyclin D1	Homo sapiens	36-45
14690578-3	2003	IgH gene rearrangement was detected in 33 paraffin-embedded cHL tissue and 6 microsectioned H/RS cell samples.	Paraffin	42-50	immunoglobulin heavy locus	Homo sapiens	0-3
11146438-7	2001	Immunohistochemistry of paraffin-embedded breast biopsy specimens showed significantly greater levels of EFP in lactating breast and fibroadenomata compared to normal breast (p&lt;0.001 and p = 0.001, respectively), which is likely to be a result of estrogen responsiveness.	Paraffin	24-32	tripartite motif containing 25	Homo sapiens	105-108
12883690-4	2003	Nm23-H1 expressions were evaluated on paraffin-embedded tissue by immunohistochemistry; DNA-ploidy and SPF on frozen tissue by flow-cytometric analysis.	Paraffin	38-46	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-7
11396126-6	2001	In order to detect LRP we have used the paraffin-embedded sections of the normal human lung tissue.	Paraffin	40-48	major vault protein	Homo sapiens	19-22
14599947-2	2003	METHODS: The expression of the mrp gene encoding MRP and mRNAmrp was determined in tissues from 54 untreated patients with HCC, adjacent tissues from 24 patients with HCC and archival paraffin-embedded tissues from 12 patients with posthepatic cirrhosis.	Paraffin	184-192	ATP binding cassette subfamily C member 3	Homo sapiens	31-34
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Paraffin	33-41	transforming growth factor, beta 1	Mus musculus	102-112
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Paraffin	33-41	transforming growth factor, beta 1	Mus musculus	102-110
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Paraffin	33-41	transforming growth factor beta receptor 2	Homo sapiens	131-143
11195465-6	2000	A panel of 45 formalin-fixed and paraffin-embedded NSCLC specimens showed positive immunostaining for TGF-beta 1, TGF-beta RI, and TGF-beta RII, with reduced TGF-beta RII in poorly differentiated adenocarcinomas and squamous cell carcinomas and some moderately differentiated adenocarcinomas.	Paraffin	33-41	transforming growth factor beta receptor 2	Homo sapiens	158-170
12810581-10	2003	Expression of the M1, M2, and M3 muscarinic receptor subtypes was also confirmed in paraffin-embedded human small intestine sections by double immunofluorescent staining.	Paraffin	84-92	cholinergic receptor muscarinic 3	Homo sapiens	30-52
11123763-10	2000	Although chromosome analysis was not performed, EWS-FLI1 chimera gene was identified by reverse transcriptase-polymerase chain reaction on the freshly frozen specimen and fluorescence in situ hybridization on paraffin sections.	Paraffin	209-217	EWS RNA binding protein 1	Homo sapiens	48-51
11103961-1	2000	Nm23 protein expression was analyzed by immunohistochemical staining using formalin-fixed, paraffin-embedded sections from 39 cases with osteosarcomas and compared with the histologic findings and early metastasis for the purpose of detecting nm23 expression in osteosarcoma and elucidating the clinical significance of its expression.	Paraffin	91-99	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
12838026-6	2003	RESULTS: The overexpression of eIF4E was observed in all 37 paraffin-embedded samples of laryngeal squamous cell carcinoma, whereas no staining was noticed in vocal cords polyps samples.	Paraffin	60-68	eukaryotic translation initiation factor 4E	Homo sapiens	31-36
11021819-3	2000	We examined BCL10 protein expression in various normal tissues and B-cell lymphomas by immunohistochemistry of formalin-fixed and paraffin-embedded tissues using mouse BCL10 monoclonal antibodies.	Paraffin	130-138	BCL10 immune signaling adaptor	Homo sapiens	12-17
12719976-6	2003	Using this technique, the formalin-fixed, paraffin-embedded human and rat normal liver tissue sections showed the vinculin immunoreactivity along the sinusoidal wall.	Paraffin	42-50	vinculin	Rattus norvegicus	114-122
10912946-1	2000	Desmoplastic small round-cell tumor of the paratesticular region: report of an adult case with demonstration of EWS and WT1 gene fusion using paraffin-embedded tissue.	Paraffin	142-150	EWS RNA binding protein 1	Homo sapiens	112-115
12811859-1	2003	BACKGROUND: Different polymerase chain reaction (PCR) assays have proved to be useful tools for the detection of clonal immunoglobulin heavy chain (IgH) gene rearrangements in frozen or paraffin-embedded tissues.	Paraffin	186-194	immunoglobulin heavy locus	Homo sapiens	148-151
12903483-2	2000	METHODS: The follicular cycles of rat hair were determined firstly and then the distribution and quantity of osteopontin mRNA on the paraffin sections of skin and hair follicles of Wistar rats were determined, aged from embryonic 14-18 days and postnatal 1-61 days, were investigated by radiolabel in situ hybridization technique.	Paraffin	133-141	secreted phosphoprotein 1	Rattus norvegicus	109-120
10760319-0	2000	Quality control and sensitivity of polymerase chain reaction techniques for the assessment of immunoglobulin heavy chain gene rearrangements from fixed- and paraffin-embedded samples.	Paraffin	157-165	immunoglobulin heavy constant delta	Homo sapiens	94-120
12766578-5	2003	We performed immunohistochemistry using a polyclonal antibody to the C-terminal portion of TFE3 in 40 formalin-fixed, paraffin-embedded tumors characterized by TFE3 gene fusions, including 19 alveolar soft part sarcoma (of which nine were molecularly confirmed) and 21 renal carcinomas with cytogenetically confirmed characteristic Xp11.2 translocations and/or fusion transcripts involving TFE3 (11 PRCC-TFE3, 7 ASPL-TFE3, 3 PSF-TFE3).	Paraffin	118-126	transcription factor binding to IGHM enhancer 3	Homo sapiens	91-95
10760319-10	2000	In this study, we showed that the use of paraffin-embedded tissue is efficient for the study of IgH gene rearrangement.	Paraffin	41-49	immunoglobulin heavy constant delta	Homo sapiens	96-99
10759265-9	2000	The detection of B19 DNA in these tissues was confirmed by detection of B19 DNA in six separately stored paraffin-embedded placental tissues.	Paraffin	105-113	eva-1 homolog C	Homo sapiens	17-20
12846417-2	2003	Recently an immunohistochemical (IHC) method for ODC determinations in formalin-fixed paraffin-embedded tissues has been developed.	Paraffin	86-94	ornithine decarboxylase 1	Homo sapiens	49-52
10766191-3	2000	Immunohistochemistry for the Dpc4 protein in formalin-fixed, paraffin-embedded tissue is a sensitive and specific marker for DPC4 gene status, providing a tool to examine DPC4 status in these putative precursor lesions.	Paraffin	61-69	SMAD family member 4	Homo sapiens	29-33
12772203-3	2003	METHODS: Apo D expression was analyzed in 32 paraffin-embedded tissues from patients with invasive cutaneous malignant melanomas, in 8 samples from in situ melanoma, and in 10 samples from 10 benign lesions (4 dermal melanocytic nevi, 4 compound melanocytic nevi, and 2 dysplastic melanocytic nevi), using immunohistochemical techniques.	Paraffin	45-53	apolipoprotein D	Homo sapiens	9-14
10889911-5	2000	These results indicate that SYT-SSX fusion transcripts are found in both epithelial and spindle cell areas of biphasic synovial sarcoma, and RT-DOP-PCR-PCR analysis is a useful method for detection of extremely small amounts of mRNA in microdissected samples from archival formalin fixed, paraffin wax embedded tumour tissues.	Paraffin	289-301	synaptotagmin 1	Homo sapiens	28-31
10889911-5	2000	These results indicate that SYT-SSX fusion transcripts are found in both epithelial and spindle cell areas of biphasic synovial sarcoma, and RT-DOP-PCR-PCR analysis is a useful method for detection of extremely small amounts of mRNA in microdissected samples from archival formalin fixed, paraffin wax embedded tumour tissues.	Paraffin	289-301	SSX family member 2	Homo sapiens	32-35
12753709-4	2003	METHODS: The existence of HPV DNA and the expression of FHIT gene at protein level in esophageal carcinoma tissues were determined with PCR and immunohistochemical staining, respectively, in 128 archival paraffin-embedded tissue blocks of esophageal squamous carcinoma from the high incidence area of Cixian and 24 tissue blocks from the non-high incidence area.	Paraffin	204-212	fragile histidine triad diadenosine triphosphatase	Homo sapiens	56-60
12707028-8	2003	In addition, the mRNA levels of cyclin D1 and Stat 3 were determined by quantitative real-time reverse transcriptase-polymerase chain reaction of paraffin-embedded microdissected tissue.	Paraffin	146-154	cyclin D1	Homo sapiens	32-41
11866899-3	2000	Immunohistochemical staining was performed in paraffin sections by using polyclonal antibody anti-p80 and other monoclonal antibodies.	Paraffin	46-54	coilin	Homo sapiens	98-101
12747626-4	2003	Paraffin sections of gastric cancer were stained with anti-MUC1 antibody by the avidin-biotinylated peroxidase complex method.	Paraffin	0-8	mucin 1, cell surface associated	Homo sapiens	59-63
10937050-5	2000	The aim of this study was to evaluate and optimize a method for detection of cyclin D1 by paraffin section immunoperoxidase staining.	Paraffin	90-98	cyclin D1	Homo sapiens	77-86
12747626-7	2003	RESULTS: The incubation of paraffin sections with ICG-sulfo-OSu-labeled MUC1 antibody resulted in positive staining of the tumor sites by an IR fluorescence imaging system, and the intensity of fluorescence was increased depending on the concentration of octylglucoside and grade of imaging processing.	Paraffin	27-35	mucin 1, cell surface associated	Homo sapiens	72-76
10937050-14	2000	We conclude that cyclin D1 immunostaining of formalin-fixed, paraffin-embedded tissue can be reliably achieved by heat induces antigen retrieval and a cocktail of two monoclonal antibodies.	Paraffin	61-69	cyclin D1	Homo sapiens	17-26
12665330-0	2003	Estrogen and progesterone receptor assay in paraffin-embedded breast cancer--reproducibility of assessment.	Paraffin	44-52	progesterone receptor	Homo sapiens	13-34
10667416-0	1999	The Mi15 monoclonal antibody (anti-syndecan-1) is a reliable marker for quantifying plasma cells in paraffin-embedded bone marrow biopsy specimens.	Paraffin	100-108	syndecan 1	Homo sapiens	35-45
10667416-3	1999	Using the MAb MI15, we investigated the expression of syndecan-1 in routinely paraffin-embedded tissues.	Paraffin	78-86	syndecan 1	Homo sapiens	54-64
12680175-2	2003	MATERIALS AND METHODS: Estrogen and progesterone receptor expression was investigated by immunohistochemistry from paraffin-embedded tissue in 21 patients with uterine LMS.	Paraffin	115-123	progesterone receptor	Homo sapiens	36-57
10541284-4	1999	By immunohistochemistry, both COX-1 and COX-2 were localized to intercalated cells of the CCD on paraffin-embedded mouse kidney sections.	Paraffin	97-105	cytochrome c oxidase II, mitochondrial	Mus musculus	40-45
21329602-2	2002	METHODS: Fhit protein expression was detected in 92 cases of formalin-fixed, paraffin-embedded human lung cancer by citrate-microwave-SP immunohistochemical method, of which 52 were non-small cell cancer (NSCLC) and 40 small cell cancer (SCLC).	Paraffin	77-85	fragile histidine triad diadenosine triphosphatase	Homo sapiens	9-13
10645225-5	1999	METHODS: Cyclin D1 immunohistochemistry was performed on 17 paraffin embedded Kaposi sarcoma samples from 16 patients.	Paraffin	60-68	cyclin D1	Homo sapiens	9-18
12351664-2	2002	RT-PCR for the decalcified paraffin sections indicated expression of MMP-8 and MMP-13 in the periodontal tissues.	Paraffin	27-35	matrix metallopeptidase 8	Rattus norvegicus	69-74
10375116-2	1999	METHODS: The authors performed a retrospective analysis for allelic deletion of the adenomatous polyposis coli (APC) and PTCH gene loci using paraffin embedded medulloblastoma specimens from patients who were admitted to Children"s National Medical Center in Washington, DC, between 1982 and 1997.	Paraffin	142-150	APC regulator of WNT signaling pathway	Homo sapiens	84-110
12201868-4	2002	A sheep antihuman int-2 antibody was applied to paraffin-embedded tissue sections from the tumor samples.	Paraffin	48-56	fibroblast growth factor 3	Homo sapiens	18-23
10362700-7	1999	A higher staining of the intima-media was observed by using an anti-PDGF-A chain polyclonal antibody on paraffin-embedded sections.	Paraffin	104-112	platelet derived growth factor subunit A	Rattus norvegicus	68-74
12237880-1	2002	This study we presents a novel anti-occludin monoclonal antibody that can be used for formalin-fixed, paraffin-embedded tissue sections.	Paraffin	102-110	occludin	Homo sapiens	36-44
12208897-4	2002	METHODS: STK15 protein was visualized by immunohistochemistry in 205 formalin-fixed, paraffin-embedded human bladder tumors.	Paraffin	85-93	aurora kinase A	Homo sapiens	9-14
10344220-12	1999	PRO:4-216 and alpha-B23 showed intense immunohistochemical staining of B23/nucleophosmin in cancer nuclei compared to adjacent normal cells in paraffin-embedded prostate tissue.	Paraffin	143-151	nucleophosmin 1	Homo sapiens	20-23
10344220-12	1999	PRO:4-216 and alpha-B23 showed intense immunohistochemical staining of B23/nucleophosmin in cancer nuclei compared to adjacent normal cells in paraffin-embedded prostate tissue.	Paraffin	143-151	nucleophosmin 1	Homo sapiens	71-74
10344220-12	1999	PRO:4-216 and alpha-B23 showed intense immunohistochemical staining of B23/nucleophosmin in cancer nuclei compared to adjacent normal cells in paraffin-embedded prostate tissue.	Paraffin	143-151	nucleophosmin 1	Homo sapiens	75-88
12231535-0	2002	Identification of cyclin D1 mRNA overexpression in B-cell neoplasias by real-time reverse transcription-PCR of microdissected paraffin sections.	Paraffin	126-134	cyclin D1	Homo sapiens	18-27
10329598-6	1999	So far, IGH-CCND1 fusions have been detected in all of the 51 MCL patients that we have analyzed by FISH (either on paraffin-embedded tumor samples or on peripheral blood samples).	Paraffin	116-124	immunoglobulin heavy locus	Homo sapiens	8-11
10329598-6	1999	So far, IGH-CCND1 fusions have been detected in all of the 51 MCL patients that we have analyzed by FISH (either on paraffin-embedded tumor samples or on peripheral blood samples).	Paraffin	116-124	cyclin D1	Homo sapiens	12-17
12400605-10	2002	Immunohistochemical stains performed on paraffin sections from these 6 representative cases showed differential protein expression of MLH1, MSH2, MSH6, and PMS2 when compared to normal reactive tissues from the same patient but showed no significant differences when compared to controls of non-familial, sporadic lymphomas.	Paraffin	40-48	mutS homolog 2	Homo sapiens	140-144
10328092-7	1999	This result was verified by fluorescence in situ hybridization on paraffin-embedded tissue, which demonstrated EWS gene-region rearrangement.	Paraffin	66-74	EWS RNA binding protein 1	Homo sapiens	111-114
12147710-5	2002	METHODS: The expression of Wnt genes was assessed by in situ, antisense RNA hybridisation in paraffin wax embedded samples of normal and malignant human colon tissues with probes specific for the individual Wnt genes.	Paraffin	93-105	Wnt family member 2	Homo sapiens	27-30
10233842-3	1999	LAT reacts with human T cells in paraffin sections, including decalcified bone marrow trephines.	Paraffin	33-41	linker for activation of T cells	Homo sapiens	0-3
10233842-6	1999	Tested on a total of 264 paraffin-embedded tissue biopsies, LAT reacted with the great majority (96.8%) of T/NK-cell neoplasms, covering the full range of T cell maturation.	Paraffin	25-33	linker for activation of T cells	Homo sapiens	60-63
21324275-2	2002	METHODS: The expression of HER4 was detected in 70 cases of paraffin-embedded NSCLC tissues by immunohistochemical assay.	Paraffin	60-68	erb-b2 receptor tyrosine kinase 4	Homo sapiens	27-31
12094380-4	2002	Applying a polyclonal antiserum to Nup88 on paraffin sections, we found that it immunoreacts with numerous malignant neoplasms.	Paraffin	44-52	nucleoporin 88	Homo sapiens	35-40
10229506-0	1999	Expression of cyclin D1 in parathyroid carcinomas, adenomas, and hyperplasias: a paraffin immunohistochemical study.	Paraffin	81-89	cyclin D1	Homo sapiens	14-23
11893937-2	2002	Previous studies have shown that PTHrP is produced by human pancreatic cancer cell lines, can be shown in the cytoplasm and nucleus of paraffin-embedded pancreatic adenocarcinoma tumor specimens, and is secreted into the media of cultured pancreatic adenocarcinoma cells.	Paraffin	135-143	parathyroid hormone like hormone	Homo sapiens	33-38
10207840-7	1999	Cells which stained positively for T beta R-II and T beta R-III on both paraffin sections and cultured cell slides were counted.	Paraffin	72-80	transforming growth factor, beta receptor 2	Rattus norvegicus	35-63
11921454-5	2002	A monoclonal anti-human PECAM-1 antibody was used to stain 5-microm paraffin sections.	Paraffin	68-76	platelet and endothelial cell adhesion molecule 1	Homo sapiens	24-31
9949353-6	1999	To explore the role played by cyclin D1 in the pathogenesis of thyroid papillary carcinoma, we have quantitated, by computerized image analysis, the immunohistochemical expression of cyclin D1 in formalin-fixed, paraffin-embedded tissue from 35 conventional papillary carcinomas of the thyroid and correlated the results with established clinicopathologic parameters and available survival data.	Paraffin	212-220	cyclin D1	Homo sapiens	183-192
11821751-6	2002	METHODS: A monoclonal antibody directed against MICA and MICB was used to perform indirect immunohistochemistry on formalin fixed, paraffin embedded needle biopsies of kidney and pancreas allografts.	Paraffin	131-139	MHC class I polypeptide-related sequence A	Homo sapiens	48-52
11821751-6	2002	METHODS: A monoclonal antibody directed against MICA and MICB was used to perform indirect immunohistochemistry on formalin fixed, paraffin embedded needle biopsies of kidney and pancreas allografts.	Paraffin	131-139	MHC class I polypeptide-related sequence B	Homo sapiens	57-61
10025729-0	1999	Immunohistochemical assessment of keratin 16 on paraffin-embedded sections of normal and hyperproliferative skin: monoclonal antibodies Ks8.12 and LL025 in a comparative study.	Paraffin	48-56	keratin 16	Homo sapiens	34-44
11866984-0	2001	[Detection of SYT-SSX fusion gene in paraffin-embedded tissues and its clinicopathologic significance for synovial sarcoma].	Paraffin	37-45	synaptotagmin 1	Homo sapiens	14-17
11866984-0	2001	[Detection of SYT-SSX fusion gene in paraffin-embedded tissues and its clinicopathologic significance for synovial sarcoma].	Paraffin	37-45	SSX family member 2	Homo sapiens	18-21
11866984-1	2001	OBJECTIVE: To investigate the feasibility of detecting SYT-SSX fusion gene in paraffin-embedded tissues and its diagnostic significance for synovial sarcoma (SS).	Paraffin	78-86	synaptotagmin 1	Homo sapiens	55-58
11866984-1	2001	OBJECTIVE: To investigate the feasibility of detecting SYT-SSX fusion gene in paraffin-embedded tissues and its diagnostic significance for synovial sarcoma (SS).	Paraffin	78-86	SSX family member 2	Homo sapiens	59-62
12080677-1	1999	In order to investigate the relationship between the regulators of cell cycle and cutaneous squamous cell carcinoma(SCC), we used an immunohistochemical staining technique to examine the expression of cyclin D1, p16 and Rb in the paraffin embedded skin cancer tissues of 30 patients with SCC.	Paraffin	230-238	cyclin D1	Homo sapiens	201-210
11866984-13	2001	CONCLUSIONS: (1) Detection of SYT-SSX fusion gene in paraffin-embedded tissues was found to be a sensitive and specific method for the diagnosis and differential diagnosis of synovial sarcoma.	Paraffin	53-61	synaptotagmin 1	Homo sapiens	30-33
11701669-6	2001	We analyzed the immunohistochemical expression of galectin-3 in 17 MICs and 52 follicular adenomas in both preoperative paraffin-embedded cytological human thyroid sediments (cell blocks) obtained by FNAB and in the corresponding surgical specimens.	Paraffin	120-128	galectin 3	Homo sapiens	50-60
9842967-3	1998	Routine labeling streptavidin-biotin immuno-histochemistry with the nm23-H1 murine monoclonal antibody was employed to study the expression of nm23-H1 protein in paraffin-embedded specimens from 231 patients with NPC treated in our hospital.	Paraffin	162-170	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	143-150
11566495-1	2001	Amplification of CCND1 was studied in 23 tongue carcinoma patients by fluorescence in situ hybridization (FISH) using a paraffin embedded specimen.	Paraffin	120-128	cyclin D1	Homo sapiens	17-22
9846971-0	1998	Detection of SYT-SSX fusion transcripts in synovial sarcoma by reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues.	Paraffin	126-134	synaptotagmin 1	Homo sapiens	13-16
9846971-2	1998	In this study, we conducted a reverse transcription-polymerase chain reaction-based assay to detect the SYT-SSX fusion gene transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from a series of 32 synovial sarcoma cases including 6 tumors found in unusual anatomical sites.	Paraffin	167-175	synaptotagmin 1	Homo sapiens	104-107
9846971-2	1998	In this study, we conducted a reverse transcription-polymerase chain reaction-based assay to detect the SYT-SSX fusion gene transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from a series of 32 synovial sarcoma cases including 6 tumors found in unusual anatomical sites.	Paraffin	167-175	SSX family member 2	Homo sapiens	108-111
9846971-3	1998	The SYT-SSX fusion transcripts could be detected in 30 of 32 paraffin-embedded specimens (94%).	Paraffin	61-69	synaptotagmin 1	Homo sapiens	4-7
9846971-3	1998	The SYT-SSX fusion transcripts could be detected in 30 of 32 paraffin-embedded specimens (94%).	Paraffin	61-69	SSX family member 2	Homo sapiens	8-11
11601138-2	2001	Cyclin D1 expression was evaluated by immunohistochemical analysis and biotin-labeled in situ hybridization (ISH) in a series of 71 decalcified, paraffin-embedded bone marrow biopsy specimens from patients with multiple myeloma (MM).	Paraffin	145-153	cyclin D1	Homo sapiens	0-9
11601138-6	2001	Our findings demonstrate the following: (1) ISH for cyclin D1 mRNA is a sensitive method for the evaluation of cyclin D1 overexpression in paraffin-embedded bone marrow biopsy specimens with MM.	Paraffin	139-147	cyclin D1	Homo sapiens	52-61
11601138-6	2001	Our findings demonstrate the following: (1) ISH for cyclin D1 mRNA is a sensitive method for the evaluation of cyclin D1 overexpression in paraffin-embedded bone marrow biopsy specimens with MM.	Paraffin	139-147	cyclin D1	Homo sapiens	111-120
9831207-9	1998	The most important finding of our study is optimization of the methodology for the detection of immunoglobulin heavy chain gene rearrangement and MTC region breakpoints by PCR from the DNA isolated from B-5-fixed, paraffin-embedded lymph nodes and bone marrow biopsy specimens.	Paraffin	214-222	immunoglobulin heavy constant delta	Homo sapiens	96-122
11567223-3	2001	ER-beta expression in CRC was investigated by immunohistochemical staining of sections of formalin-fixed, paraffin-embedded tissue from 55 CRC.	Paraffin	106-114	estrogen receptor 2	Homo sapiens	0-7
9796724-0	1998	Evaluation of CD23 expression in paraffin-embedded gastric lymphomas of mucosa-associated lymphoid tissue.	Paraffin	33-41	Fc epsilon receptor II	Homo sapiens	14-18
9796724-2	1998	Reactivity for anti-CD23 (BU38) is present in paraffin-embedded tissue in the large majority of nodal small lymphocytic lymphomas, as well as in follicular center cell lymphomas.	Paraffin	46-54	Fc epsilon receptor II	Homo sapiens	20-24
11510908-2	2001	We investigated paraffin-embedded tissue sections of ten male mice with an antibody directed against the recombinant PTN.	Paraffin	16-24	pleiotrophin	Mus musculus	117-120
9796724-4	1998	We evaluated CD23 staining in paraffin-embedded tissue in a large series of gastric MALT lymphomas, as well as in cases of chronic gastritis.	Paraffin	30-38	Fc epsilon receptor II	Homo sapiens	13-17
9796724-8	1998	We used anti-CD23 (BU38) in formalin-fixed, paraffin-embedded tissue.	Paraffin	44-52	Fc epsilon receptor II	Homo sapiens	13-17
11155673-2	1998	METHODS: nm23 oncoprotein expression was measured by immunohistochemical staining using formalin fixed, paraffin embedded sections of 39 surgically resected osteosarcomas and was compared with Ki-67 expression, histological findings and early metastasis.	Paraffin	104-112	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	9-13
11337360-1	2001	We have developed a protocol for degenerate oligonucleotide-primed-polymerase chain reaction-based array comparative genomic hybridization (array CGH) that, when combined with a laser microdissection technique, allows the analysis of cancer cell populations isolated from routine, formalin-fixed, paraffin-embedded tissue samples.	Paraffin	297-305	hypertrichosis 2 (generalised, congenital)	Homo sapiens	146-149
9665805-5	1998	PGHS-2 immunoreactivity in paraffin sections from TPA-treated skin showed a nuclear in some and a perinuclear and cytoplasmic localization in other keratinocytes.	Paraffin	27-35	prostaglandin-endoperoxide synthase 2	Mus musculus	0-6
11337360-4	2001	The array CGH method described here will allow the genetic analysis of paraffin-embedded human cancer materials for example in the context of clinical trials.	Paraffin	71-79	hypertrichosis 2 (generalised, congenital)	Homo sapiens	10-13
11519863-4	2001	Therefore, we developed an immunohistochemical method for ODC determination which can be applied to formalin-fixed, paraffin-embedded tissue sections.	Paraffin	116-124	ornithine decarboxylase 1	Homo sapiens	58-61
11378576-9	2001	Results showed that, CD10 by paraffin IH(PIH) was positive in 23 [18(strong); 3(moderate); 2(weak)] and negative in 6(3, Grade 2; 3, Grade 3).	Paraffin	29-37	pregnancy-induced hypertension (pre-eclampsia, eclampsia, toxemia of pregnancy included)	Homo sapiens	41-44
9688179-7	1998	We analyzed the expression of cyclin D1 nuclear protein in paraffin sections using an immunoperoxidase technique in 17 cases diagnosed as SMZL.	Paraffin	59-67	cyclin D1	Homo sapiens	30-39
9688183-0	1998	Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma.	Paraffin	67-75	synaptotagmin 1	Homo sapiens	17-20
9688183-0	1998	Detection of the SYT-SSX fusion transcripts in formaldehyde-fixed, paraffin-embedded tissue: a reverse transcription polymerase chain reaction amplification assay useful in the diagnosis of synovial sarcoma.	Paraffin	67-75	SSX family member 2	Homo sapiens	21-24
11150857-4	2001	The results obtained in this study, beside demonstrating the usefulness of the nonradioactive technique for the detection of TGF alpha mRNA in paraffin sections, allowed TGF alpha-producing cells to be seen in developing kidneys.	Paraffin	143-151	transforming growth factor alpha	Homo sapiens	125-134
9624417-5	1998	METHODS: Expression of the cyclin D1 and Rb genes was detected by standard immunnohistochemistry using paraffin wax embedded sections.	Paraffin	103-115	cyclin D1	Homo sapiens	27-36
9624417-5	1998	METHODS: Expression of the cyclin D1 and Rb genes was detected by standard immunnohistochemistry using paraffin wax embedded sections.	Paraffin	103-115	RB transcriptional corepressor 1	Homo sapiens	41-43
11798878-2	2001	METHODS: Immunohistochemistry and in situ hybridization were used to detect the expression of pRB and E(2)F(1) mRNA in the paraffin embedded tissues of 78 cases of human neuroendocrine lung tumor.	Paraffin	123-131	RB transcriptional corepressor 1	Homo sapiens	94-97
9463579-6	1997	A chimeric transcript of the EWS/FLI-1 fusion gene detected by a nested reverse transcriptase-polymerase chain reaction using formalin-fixed paraffin-embedded tissue justified the diagnosis of pPNET.	Paraffin	141-149	EWS RNA binding protein 1	Homo sapiens	29-32
11167212-3	2001	METHODS: Immunohistochemical evaluation was used to examine apolipoprotein D expression in paraffin blocks from 58 endometrial carcinomas.	Paraffin	91-99	apolipoprotein D	Homo sapiens	60-76
9334495-2	1997	The staining pattern for vimentin in the paraffin sections was generally comparable to that in other animal species with regard to endothelial cells, vascular wall cells, muscle cells and fibroblasts.	Paraffin	41-49	vimentin	Melopsittacus undulatus	25-33
11165398-2	2001	Syndecan-1 was immunohistochemically stained with a polyclonal antibody in 115 paraffin-embedded specimens; 84 cases out of 97 non-small cell lung cancer (NSCLC) and eight cases out of 18 small cell lung cancer (SCLC) were positively stained.	Paraffin	79-87	syndecan 1	Homo sapiens	0-10
10451965-2	1997	METHODS: Proliferating cell nuclear antigen (PCNA) and argyrophilic nucleolar organizer regions (AgNORs) in paraffin-embedded Rb specimens from 48 cases were detected by LSAB immunohistochemical method using an anti-PCNA monoclonal antibody and the technique of ploton.	Paraffin	108-116	RB transcriptional corepressor 1	Homo sapiens	126-128
9191521-8	1997	Among resistance-related proteins, expression of metallothioneins (MTs), glutathione-S-transferase pi (GST pi), heat shock protein 27 (Hsp27), and lung resistance-related protein (LRP) was evaluated immunohistochemically in paraffin sections.	Paraffin	224-232	major vault protein	Homo sapiens	180-183
9205870-0	1997	Detectability of retinoblastoma (Rb) gene product and p53 antigen expression decreases in stored paraffin sections.	Paraffin	97-105	RB transcriptional corepressor 1	Homo sapiens	17-31
9205870-0	1997	Detectability of retinoblastoma (Rb) gene product and p53 antigen expression decreases in stored paraffin sections.	Paraffin	97-105	RB transcriptional corepressor 1	Homo sapiens	33-35
11426536-1	2001	We evaluated immunohistochemically the expression of two negative regulators of the cell cycle, namely retinoblastoma gene product (pRb) and WAF1/Cip1 gene product (p21), in paraffin sections from 93 patients with non-Hodgkin"s lymphomas (NHL) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival.	Paraffin	174-182	RB transcriptional corepressor 1	Homo sapiens	103-136
9209449-3	1997	In the present study, we have immunohistochemically examined the cyclin D1 protein in a large series of 315 malignant lymphomas including 39 MCLs on paraffin sections.	Paraffin	149-157	cyclin D1	Homo sapiens	65-74
11504311-2	2001	Immunohistochemical overexpression of cyclin D1 was determined in paraffin-embedded specimens from diagnostic biopsies of 89 primary cases of squamous cell carcinoma of the head and neck (SCCHN), using a polyclonal antiserum.	Paraffin	66-74	cyclin D1	Homo sapiens	38-47
9209450-5	1997	Paraffin sections of 105 cases of ALCL were immunostained using anti-p80 antibody, and 30 of them were shown to express p80.	Paraffin	0-8	coilin	Homo sapiens	69-72
11172303-3	2001	It bears the t(X;18) (SYT;SSX) translocation, which seems to be specific for this tumor type and can be detected in paraffin-embedded tissue, using reverse transcriptase-polymerase chain reaction (RT-PCR).	Paraffin	116-124	synaptotagmin 1	Homo sapiens	22-25
9048644-3	1997	Immunohistochemical staining of formalin-fixed paraffin-embedded rat and human pancreas using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection revealed that CYP2J2 protein expression was highly localized to cells in the islets of Langerhans, with minimal staining in pancreatic exocrine cells.	Paraffin	47-55	cytochrome P450 family 2 subfamily J member 2	Homo sapiens	167-173
11172303-12	2001	This study shows that the detection of the SS t(X;18) (SYT-SSX) in paraffin-embedded tissue is feasible with a 100% specificity and an overall 96% sensitivity, provided non-Bouin"s fluid fixation is used.	Paraffin	67-75	synaptotagmin 1	Homo sapiens	55-58
21340794-6	2001	This was first described for polyclonal hMSH2 antibody, in paraffin-embedded tissue, by Wilson et al.	Paraffin	59-67	mutS homolog 2	Homo sapiens	40-45
21340794-18	2001	We describe here a method for immunohistochemistry for hMSH2, hMLH1, and hPMS2 in both fresh and paraffin-embedded material.	Paraffin	97-105	mutS homolog 2	Homo sapiens	55-60
11574776-2	2001	We analyzed Fhit expression using an immunohistochemical method in invasive carcinoma, carcinoma in situ (CIS) and dysplasia, in paraffin sections of 75 esophageal squamous cell carcinomas (ESCs) to further elucidate the role of Fhit protein in esophageal carcinogenesis.	Paraffin	129-137	fragile histidine triad diadenosine triphosphatase	Homo sapiens	12-16
9023553-4	1997	In this study, we have used a recombinant fusion protein representing part of the epsilon subunit of the CD3 molecule to generate a novel monoclonal antibody (NCL-CD3-PS1) effective in paraffin sections.	Paraffin	185-193	nucleolin	Homo sapiens	159-162
9021364-1	1996	The expression of endometrial progesterone receptor mRNA during the human menstrual cycle and in Norplant users was studied using digoxigenin-labelled ribonucleic probes for in-situ hybridization on 6 microns paraffin embedded endometrial sections.	Paraffin	209-217	progesterone receptor	Homo sapiens	30-51
11482578-7	2001	MMP-2 expression was scored immunohistochemically on paraffin tissue sections using the avidin-biotin-peroxidase method.	Paraffin	53-61	matrix metallopeptidase 2	Homo sapiens	0-5
11131586-3	2000	PROCEDURE: Expression of mRNA of inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta IL-6, and IL-8 in formalin-fixed paraffin-embedded blocks of lymphoid tissue (lymph nodes and tonsil) of swine experimentally infected with M. avium serovar 2 was compared with that of noninfected pigs.	Paraffin	160-168	tumor necrosis factor	Sus scrofa	64-91
8883955-2	1996	After otherwise identical conditions, lesser background and stronger GnRH hybridization signals were observed on cryostat vs. paraffin sections.	Paraffin	126-134	gonadotropin releasing hormone 1	Homo sapiens	69-73
11131586-3	2000	PROCEDURE: Expression of mRNA of inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta IL-6, and IL-8 in formalin-fixed paraffin-embedded blocks of lymphoid tissue (lymph nodes and tonsil) of swine experimentally infected with M. avium serovar 2 was compared with that of noninfected pigs.	Paraffin	160-168	tumor necrosis factor	Sus scrofa	93-101
11131586-3	2000	PROCEDURE: Expression of mRNA of inflammatory cytokines such as tumor necrosis factor alpha (TNFalpha), interleukin (IL)-1beta IL-6, and IL-8 in formalin-fixed paraffin-embedded blocks of lymphoid tissue (lymph nodes and tonsil) of swine experimentally infected with M. avium serovar 2 was compared with that of noninfected pigs.	Paraffin	160-168	C-X-C motif chemokine ligand 8	Sus scrofa	137-141
9021682-7	1996	When paraffin sections of 105 cases of ALCL were stained using the anti-p80 antibody, 30 were shown to be p80 positive Clinicopathological comparison between p80-positive and p80-negative ALCLs revealed that the p80-positive cases occurred in a much younger patient age group and that the patients showed a far better 5-year survival rate.	Paraffin	5-13	coilin	Homo sapiens	106-109
11199480-8	2000	Using immunohistochemistry on methanol/acetic acid-fixed, paraffin-embedded pancreas, the CCKA receptor could successfully be localized in islet cells.	Paraffin	58-66	cholecystokinin A receptor	Rattus norvegicus	90-103
11111200-5	2000	METHOD: Polymerase chain reaction and DNA sequencing were used to detect immunoglobulin heavy chain (IgH) rearrangement in paraffin-embedded specimens from asynchronous tumors affecting the right and left testis of a 85-year-old man with an interval period of 13 months.	Paraffin	123-131	immunoglobulin heavy constant delta	Homo sapiens	73-99
8774494-0	1996	Development of an optimal protocol for antigen retrieval: a "test battery" approach exemplified with reference to the staining of retinoblastoma protein (pRB) in formalin-fixed paraffin sections.	Paraffin	177-185	RB transcriptional corepressor 1	Homo sapiens	154-157
8774494-3	1996	The immunohistochemical detection of pRB expression in formalin-paraffin sections of human cancer has potential advantages of convenience, economy, and compatibility with routine surgical pathology practice.	Paraffin	64-72	RB transcriptional corepressor 1	Homo sapiens	37-40
8774494-5	1996	In this study, the antigen retrieval (AR) method has been applied to the immunohistochemical detection of pRB in paraffin-embedded tissues and a "test battery" approach has been developed to identify the principal variables that result in the optimal AR protocol.	Paraffin	113-121	RB transcriptional corepressor 1	Homo sapiens	106-109
8774494-10	1996	A consistent intensity of immunohistochemical staining for pRB was achieved using the identified optimal AR protocol on formalin-paraffin sections.	Paraffin	129-137	RB transcriptional corepressor 1	Homo sapiens	59-62
11111200-5	2000	METHOD: Polymerase chain reaction and DNA sequencing were used to detect immunoglobulin heavy chain (IgH) rearrangement in paraffin-embedded specimens from asynchronous tumors affecting the right and left testis of a 85-year-old man with an interval period of 13 months.	Paraffin	123-131	immunoglobulin heavy constant delta	Homo sapiens	101-104
11144927-3	2000	Cyclin D1 immunohistochemistry in fixed, paraffin-embedded tissue contributes to the precise and reproducible diagnosis of MCL without the requirement of fresh tissue.	Paraffin	41-49	cyclin D1	Homo sapiens	0-9
8916443-3	1996	CD40 expression provides a new potential tool for the identification of RS cells of HD in fixed and paraffin-embedded material.	Paraffin	100-108	CD40 molecule	Homo sapiens	0-4
8857669-0	1996	Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.	Paraffin	98-106	methionine adenosyltransferase 1A	Homo sapiens	20-25
11144927-9	2000	In summary, although the total number of studied cases is small and a larger series of cases may be required to confirm our data, we present optimized immunohistochemical conditions for cyclin D1 in fixed, paraffin-embedded tissue that can be useful in distinguishing MCL and hairy cell leukemia from other small B-cell neoplasms and reactive lymphoid infiltrates.	Paraffin	206-214	cyclin D1	Homo sapiens	186-195
11425189-0	2000	Alkali-catalyzed beta-elimination of periodate-oxidized glycans: a novel method of chemical deglycosylation of mucin gene products in paraffin embedded sections.	Paraffin	134-142	LOC100508689	Homo sapiens	111-116
8778315-4	1996	Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections after microwave antigen retrieval, using a nucleophosmin/B23-specific monoclonal antibody, showed almost exclusively diffuse nuclear reactivity of a majority of the epithelial cells in non-neoplastic mucosa: in adenomas, reactivity was almost exclusively nucleolar and in carcinomas, nuclear as well as nucleolar staining was observed.	Paraffin	48-56	nucleophosmin 1	Homo sapiens	125-138
8778315-4	1996	Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections after microwave antigen retrieval, using a nucleophosmin/B23-specific monoclonal antibody, showed almost exclusively diffuse nuclear reactivity of a majority of the epithelial cells in non-neoplastic mucosa: in adenomas, reactivity was almost exclusively nucleolar and in carcinomas, nuclear as well as nucleolar staining was observed.	Paraffin	48-56	nucleophosmin 1	Homo sapiens	139-142
2801883-4	1989	Using monoclonal antibodies (UCHL1, MB2, MT1, LN1, LN2, and L26) that are effective in paraffin-embedded, B5-fixed tissue, 13 cases of DML were studied.	Paraffin	87-95	ubiquitin C-terminal hydrolase L1	Homo sapiens	29-34
11425189-3	2000	In this study, we describe a novel method of chemical deglycosylation of mucin gene products on paraffin embedded formalin-fixed tissue sections.	Paraffin	96-104	LOC100508689	Homo sapiens	73-78
11097366-2	2000	The aim of the present study was to define whether CD is a reliable ganglion cell differentiation marker in routinely fixed, paraffin-embedded tissues.	Paraffin	125-133	cathepsin D	Homo sapiens	51-53
2633112-1	1989	The indirect immunoperoxidase technique has been used to demonstrate Lea and Leb antigens in paraffin sections of both morphologically normal gastric and colonic mucosae and their neoplastic counterparts.	Paraffin	93-101	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	77-80
8535713-2	1995	PATIENTS AND METHODS: The immunoreactivity of nm23 protein and proliferating cell nuclear antigen (PCNA) were evaluated in paraffin-embedded tumour samples obtained from 74 patients with TCC of the bladder who underwent total cystectomy between 1981 and 1993 and compared with the histological findings and clinical outcome.	Paraffin	123-131	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	46-50
2575456-11	1989	From this it is concluded that cyclin/PCNA immunostaining can be used: (1) In formaldehyde-fixed tissues (including existing material stored as paraffin blocks): for defining and mapping the proliferative (or germinative) compartment.	Paraffin	144-152	proliferating cell nuclear antigen	Homo sapiens	31-37
2575456-11	1989	From this it is concluded that cyclin/PCNA immunostaining can be used: (1) In formaldehyde-fixed tissues (including existing material stored as paraffin blocks): for defining and mapping the proliferative (or germinative) compartment.	Paraffin	144-152	proliferating cell nuclear antigen	Homo sapiens	38-42
11097366-6	2000	We conclude that CD is a reliable ganglion cell differentiation marker, which can be used routinely to stain developing and mature ganglion cells in formalin-fixed, paraffin-embedded tissues.	Paraffin	165-173	cathepsin D	Homo sapiens	17-19
11007039-0	2000	Myogenin is a specific marker for rhabdomyosarcoma: an immunohistochemical study in paraffin-embedded tissues.	Paraffin	84-92	myogenin	Homo sapiens	0-8
2671152-1	1989	We generated a monoclonal antibody (MAb), designated LN-6, directed against human vimentin, which retains its immunoreactivity in B5-fixed, paraffin-embedded tissues.	Paraffin	140-148	vimentin	Homo sapiens	82-90
7572910-5	1995	RESULTS: Paraffin-embedded tumor specimens from 13 of 14 cases of gastric adenocarcinoma stained positively with the antibody to the carboxy terminus of the PTHrP peptide, but none stained positively with the antibody directed against the amino terminus.	Paraffin	9-17	parathyroid hormone like hormone	Homo sapiens	157-162
2564004-4	1989	A histopathological examination of the CA1 region of the dorsal hippocampus and neocortex from each hemisphere was made on paraffin-embedded sections following 7 days of survival.	Paraffin	123-131	carbonic anhydrase 1	Rattus norvegicus	39-42
7655022-5	1995	Paraffin sections of 105 cases of ALCL were immunostained using anti-p80 antibody, and 30 of them were shown to express p80.	Paraffin	0-8	coilin	Homo sapiens	120-123
11007039-3	2000	Commercially available antibodies capable of detecting myogenin in routinely processed formalin-fixed paraffin-embedded (FFPE) tissue are now available.	Paraffin	102-110	myogenin	Homo sapiens	55-63
11866919-0	2000	[Detection of alterations of the DPC4 gene in paraffin-embedded tissues of pancreatic carcinomas].	Paraffin	46-54	SMAD family member 4	Homo sapiens	33-37
2751258-1	1989	The immunohistochemical expression of CEA in formalin-fixed paraffin sections in urinary bladder carcinomas was compared to the use of polyclonal anti-CEA antiserum (P-CEA), NCA-absorbed anti-CEA (NCA-aCEA) and monoclonal antibody to CEA (M-CEA).	Paraffin	60-68	CEA cell adhesion molecule 5	Homo sapiens	38-41
11866919-1	2000	OBJECTIVE: To examine the alteration and significance of the DPC4 gene in paraffin-embedded tissues of pancreatic carcinomas.	Paraffin	74-82	SMAD family member 4	Homo sapiens	61-65
7501113-9	1995	Our results confirm that the immunodetection of the PgR and the Ki-67 antigen on the paraffin sections of meningiomas provides a practical tool for estimating the biological behavior of the meningiomas.	Paraffin	85-93	progesterone receptor	Homo sapiens	52-55
11866919-7	2000	The total frequency of intragenic changes of DPC4 in paraffin-embedded tissues was 45.6% (21/46).	Paraffin	53-61	SMAD family member 4	Homo sapiens	45-49
10923923-10	2000	The results indicate that microdissection of small nodular lymphoid infiltrates from paraffin-BM sections increases the sensitivity of IgH gene rearrangement analysis.	Paraffin	85-93	immunoglobulin heavy constant delta	Homo sapiens	135-138
7777480-1	1995	Proliferating cell nuclear antigen (PCNA), an auxiliary protein of DNA polymerase-delta, has recently been proposed as a marker of proliferation that is detectable in formalin-fixed paraffin-embedded tissue.	Paraffin	182-190	DNA polymerase delta 1, catalytic subunit	Homo sapiens	67-87
2670616-2	1989	The aim of the study was to evaluate the incidence of the reactions for vimentin and desmin in gastric leiomyomas routinely processed in formalin and embedded i paraffin.	Paraffin	161-169	vimentin	Homo sapiens	72-80
2499107-1	1989	Assessment of immunohistochemical demonstration of desmin using paraffin sections and frozen sections.	Paraffin	64-72	desmin	Homo sapiens	51-57
2499107-6	1989	In the present study we detected desmin in 6 of 10 formalin-fixed paraffin sections (although there were differences due to the use of five commercially available types of anti-desmin antibodies).	Paraffin	66-74	desmin	Homo sapiens	33-39
10824929-2	2000	The present study investigated Rb immunohistochemistry in a series of 111 formalin-fixed, paraffin-embedded benign and malignant thyroid lesions.	Paraffin	90-98	RB transcriptional corepressor 1	Homo sapiens	31-33
2456020-0	1988	Expression of nerve growth factor receptor in paraffin-embedded soft tissue tumors.	Paraffin	46-54	nerve growth factor receptor	Homo sapiens	14-42
7744382-3	1994	The results showed that the DNA from paraffin-embedded bone marrow biopsies could be used to detect monoclonal IgH rearrangement by PCR method.	Paraffin	37-45	immunoglobulin heavy locus	Homo sapiens	111-114
12828172-2	2000	METHODS: The levels of TIMP-3 and TIMP-4 mRNA in paraffin-embedded breast carcinoma specimens from 70 patients with primary invasive breast cancer who had undergone radical mastectomy from January of 1984 to December of 1985 were assessed by in situ hybridization assay.	Paraffin	49-57	TIMP metallopeptidase inhibitor 4	Homo sapiens	34-40
8062250-3	1994	We examined the same primary tumors for inactivation of the retinoblastoma (Rb) gene by immunohistochemical analysis of paraffin-embedded specimens.	Paraffin	120-128	RB transcriptional corepressor 1	Homo sapiens	76-78
10749136-6	2000	In the present study, we developed a monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues.	Paraffin	142-150	SSX family member 2	Homo sapiens	76-80
7959228-13	1994	These data indicate that Ad 12 can be successfully detected using PCR on paraffin embedded tissue.	Paraffin	73-81	AD12	Homo sapiens	25-30
3258470-4	1988	Although S-100 protein was positive in the majority of these DRC-1-positive cases on the paraffin embedded specimens, positive nodules were less intense and smaller in number compared with those of DRC-1 on frozen tissue specimens.	Paraffin	89-97	dynein regulatory complex subunit 1	Homo sapiens	61-66
10728754-3	2000	METHODS: The expression of sentrin-1 mRNA was examined by in situ hybridization on snap-frozen sections of normal and RA synovial tissues as well as on paraffin-embedded RA synovial specimens, including the interface of cartilage-bone and invading synovium.	Paraffin	152-160	small ubiquitin like modifier 1	Homo sapiens	27-34
2451041-2	1988	We used indirect immunohistochemical techniques to demonstrate cytoplasmic EGF in paraffin-embedded sections of the following primary prostatic tissues: benign prostatic hyperplasia (BPH) (N = 10), BPH adjacent to CAP (N = 42), clinically localized CAP (N = 45), untreated metastatic CAP (N = 10), and metastatic CAP after varying periods of androgen deprivation (N = 10).	Paraffin	82-90	epidermal growth factor	Homo sapiens	75-78
8033150-3	1994	Immunohistochemical staining of paraffin-embedded tumor sections indicated loss of retinoblastoma (RB) protein expression in all tumors showing LOH except one.	Paraffin	32-40	RB transcriptional corepressor 1	Homo sapiens	83-102
3278967-9	1988	We conclude that MT1 is a valuable marker for T cells, particularly when used with a panel of antibodies reactive with B cells in paraffin sections.	Paraffin	130-138	metallothionein 1I, pseudogene	Homo sapiens	17-20
10684708-3	2000	METHODS: Immunohistochemical evaluation was used to examine apolipoprotein D expression in paraffin blocks from 68 epithelial ovarian carcinomas.	Paraffin	91-99	apolipoprotein D	Homo sapiens	60-76
10674823-0	2000	Loss of heterozygosity of adenomatous polyposis coli gene in cutaneous tumors as determined by using polymerase chain reaction and paraffin section preparations.	Paraffin	131-139	APC regulator of WNT signaling pathway	Homo sapiens	26-52
3376759-6	1988	Extravasated plasma albumin, fibrinogen and fibronectin were demonstrated by immunohistochemistry on paraffin sections.	Paraffin	101-109	fibronectin 1	Rattus norvegicus	44-55
3059654-1	1988	The protein coded by the oncogene c-myc, p62c-myc, was measured using monoclonal antibodies and flow cytometry in nuclei derived from paraffin-wax sections of transitional cell carcinomas of the human bladder.	Paraffin	134-142	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	34-39
7805147-2	1994	The results showed that the rates of positive amplification of clonal IgH and TCR beta gene rearrangement were 71.4% (10/14) and 83.3% (10/12) respectively in the fresh tissues, and the IgH (semi-nested PCR technique) and TCR beta were 80% (12/15) and 73.3% (11/15) respectively in paraffin embedded tissues.	Paraffin	282-290	immunoglobulin heavy locus	Homo sapiens	186-189
10640992-1	2000	A study was performed to investigate the utility of polymerase chain reaction (PCR)-based analysis of immunoglobulin heavy chain (IgH) gene rearrangements for the diagnosis of low-grade malignant B-cell lymphomas on formalin-fixed, EDTA-decalcified, and paraffin-embedded bone marrow trephine biopsies.	Paraffin	254-262	immunoglobulin heavy constant delta	Homo sapiens	130-133
8206403-4	1994	ER and PgR receptors were detected by immunohistochemistry from paraffin sections.	Paraffin	64-72	progesterone receptor	Homo sapiens	7-10
3325094-1	1987	Expression of c-myc was studied immunohistochemically in 100 colorectal carcinomas, using a monoclonal antibody, Myc 1-6E10, which is purported to recognize the oncoprotein (p62c-myc) in paraffin-embedded material.	Paraffin	187-195	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-19
10674271-1	2000	The aim of the current study was to investigate the immunohistochemical expression of the retinoblastoma protein (pRB) in formalin-fixed, paraffin-embedded specimens obtained from 62 patients suffering from endometrial cancer.	Paraffin	138-146	RB transcriptional corepressor 1	Homo sapiens	114-117
2824327-1	1987	To determine the difference between normal and neoplastic myoepithelial cells, we performed immunoperoxidase staining for contractile proteins (actin and myosin) and intermediate filament proteins (vimentin and 55- to 57-kilodalton keratin) on paraffin sections from salivary gland tumors.	Paraffin	244-252	vimentin	Homo sapiens	198-239
8137214-4	1994	METHODS: The presence of PTHrp in SCC has been studied by immunohistochemistry in formalin fixed, paraffin embedded tissues.	Paraffin	98-106	parathyroid hormone like hormone	Homo sapiens	25-30
7725828-2	1994	The thyrotropin-releasing hormone (TRH)-containing neurons that project to portal capillaries of the external zone of the median eminence (ME) and fenestrated capillaries of the organum vasculosum of the lamina terminalis (OVLT) were identified on thin paraffin and thick vibratome sections using a combination of retrograde labeling with peripherally administered Fluoro-Gold and fluorescence immunocytochemistry.	Paraffin	253-261	thyrotropin releasing hormone	Rattus norvegicus	4-33
10617273-2	1999	Immunoglobulin heavy chain (IgH) gene-rearrangement analysis by polymerase chain reaction (PCR) is a reliable technique to detect B-cell monoclonality in paraffin-embedded tissue, but the presence of numerous reactive B lymphocytes in PCBCL may complicate the interpretation of clonality test results.	Paraffin	154-162	immunoglobulin heavy constant delta	Homo sapiens	0-26
7725828-2	1994	The thyrotropin-releasing hormone (TRH)-containing neurons that project to portal capillaries of the external zone of the median eminence (ME) and fenestrated capillaries of the organum vasculosum of the lamina terminalis (OVLT) were identified on thin paraffin and thick vibratome sections using a combination of retrograde labeling with peripherally administered Fluoro-Gold and fluorescence immunocytochemistry.	Paraffin	253-261	thyrotropin releasing hormone	Rattus norvegicus	35-38
7507299-5	1994	The expression of CD40 in 37 cases of Hodgkin"s disease and 23 cases of non-Hodgkin"s lymphoma (11 T cell lymphomas and 12 B cell lymphomas) was examined by paraffin section immunohistochemistry using the BB-20 monoclonal antibody.	Paraffin	157-165	CD40 molecule	Homo sapiens	18-22
3329454-3	1987	Localization of gamma-seminoprotein (gamma-Sm) was examined using horseradish peroxidase-labeled anti-gamma-Sm antibody (Chugai Corp. Ltd., Tokyo, Japan) by the enzyme-labeled antibody method in paraffin embedded specimens of 18 benign prostatic hyperplasias and 32 untreated prostatic cancers.	Paraffin	195-203	kallikrein related peptidase 3	Homo sapiens	16-35
3329454-3	1987	Localization of gamma-seminoprotein (gamma-Sm) was examined using horseradish peroxidase-labeled anti-gamma-Sm antibody (Chugai Corp. Ltd., Tokyo, Japan) by the enzyme-labeled antibody method in paraffin embedded specimens of 18 benign prostatic hyperplasias and 32 untreated prostatic cancers.	Paraffin	195-203	kallikrein related peptidase 3	Homo sapiens	37-45
10617273-2	1999	Immunoglobulin heavy chain (IgH) gene-rearrangement analysis by polymerase chain reaction (PCR) is a reliable technique to detect B-cell monoclonality in paraffin-embedded tissue, but the presence of numerous reactive B lymphocytes in PCBCL may complicate the interpretation of clonality test results.	Paraffin	154-162	immunoglobulin heavy constant delta	Homo sapiens	28-31
21566899-3	1994	Immunohistochemical staining of formalin-fixed, paraffin-embedded tissue sections from 48 colorectal carcinomas demonstrated that pRB expression was exclusively localized to the nucleus.	Paraffin	48-56	RB transcriptional corepressor 1	Homo sapiens	130-133
10417510-4	1999	We studied the expression of nNOS and PIN in paraffin sections of 177 and 58 pigment cell lesions, respectively, using immunohistochemistry; the activity of the necessary cofactor NADPH was studied in 26 frozen cases.	Paraffin	45-53	nitric oxide synthase 1	Homo sapiens	29-33
3296769-0	1987	Monoclonal antibodies (MT1, MT2, MB1, MB2, MB3) reactive with leukocyte subsets in paraffin-embedded tissue sections.	Paraffin	83-91	metallothionein 1I, pseudogene	Homo sapiens	23-26
10430278-0	1999	Desmoplastic small round-cell tumor of the paratesticular region: report of an adult case with demonstration of EWS and WT1 gene fusion using paraffin-embedded tissue.	Paraffin	142-150	EWS RNA binding protein 1	Homo sapiens	112-115
8121884-2	1993	Cathepsin D expression was immunohistochemically tested in 126 formalin-fixed and paraffin-embedded tissues from primary breast cancers.	Paraffin	82-90	cathepsin D	Homo sapiens	0-11
2426478-3	1986	Our analysis of fixation effects and immunohistochemical staining of polyclonal antibody to PSA indicates that the formalin fixation and paraffin embedding methods used previously did provide optimum localization of the antigen and the variations in the intensity of PSA staining could not be attributed to the methodology.	Paraffin	137-145	kallikrein related peptidase 3	Homo sapiens	92-95
10231400-1	1999	AIMS: We evaluated polymerase chain reaction (PCR) amplification of specific immunoglobulin heavy chain (IgH) gene rearrangements as a means of demonstrating monoclonality during follow-up of conservatively treated gastric MALT lymphoma, and compared the reproducibility of PCR on sequential frozen and paraffin-embedded endoscopic biopsies.	Paraffin	303-311	immunoglobulin heavy locus	Homo sapiens	105-108
3902971-0	1985	A simultaneous flow cytometric assay for c-myc oncoprotein and DNA in nuclei from paraffin embedded material.	Paraffin	82-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	41-46
3902971-1	1985	A simultaneous flow cytometric assay for the c-myc oncoprotein and DNA in nuclei extracted from archival paraffin wax embedded clinical biopsies is presented.	Paraffin	105-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	45-50
7506772-0	1993	Immunohistochemical detection of CD1A antigen in formalin-fixed and paraffin-embedded tissue sections with monoclonal antibody 010.	Paraffin	68-76	CD1a molecule	Homo sapiens	33-37
7506772-1	1993	The immunoreactivity of a CD1a monoclonal antibody (MAb), denoted 010, was investigated by means of the streptavidin-biotin-peroxidase method in formalin-fixed and paraffin-embedded tissues from 47 cases.	Paraffin	164-172	CD1a molecule	Homo sapiens	26-30
10231400-9	1999	CONCLUSIONS: PCR-based clonality analysis by demonstration of specific IgH gene rearrangement can be easily and reliably performed on both frozen and paraffin-embedded endoscopic biopsies.	Paraffin	150-158	immunoglobulin heavy locus	Homo sapiens	71-74
10201006-9	1999	Nonradioactive in situ hybridization studies on sections from formalin-fixed and paraffin-embedded, normally concentrating kidneys showed strong expression of BGT, SMIT, and AR mRNAs in interstitial and collecting duct cells of the papilla, whereas expression of SDH mRNA was much weaker in both cell types.	Paraffin	81-89	solute carrier family 5 member 3	Homo sapiens	164-168
2857903-1	1985	The distribution of beta 2-microglobulin was studied by an immunoperoxidase method in paraffin sections from sixteen serial graft liver biopsy samples taken after liver transplantation from four patients who had received transplants for advanced primary biliary cirrhosis.	Paraffin	86-94	beta-2-microglobulin	Homo sapiens	20-40
10474690-8	1999	CONCLUSIONS: These results confirm that PCR based IgH gene rearrangement analysis is a sensitive and specific method for demonstrating B cell clonality in whole paraffin wax embedded sections.	Paraffin	161-173	immunoglobulin heavy constant delta	Homo sapiens	50-53
2579631-1	1985	Monoclonal antibody ME491 identifies a cutaneous melanoma-associated antigen in formaldehyde-fixed, paraffin-embedded tissues.	Paraffin	100-108	CD63 molecule	Homo sapiens	20-25
2579631-1	1985	Monoclonal antibody ME491 identifies a cutaneous melanoma-associated antigen in formaldehyde-fixed, paraffin-embedded tissues.	Paraffin	100-108	ankyrin repeat domain 36B	Homo sapiens	49-76
8343047-6	1993	Expression of hCG was detected in paraffin sections, including tumor and adjacent mucosa, using immunolabeling with a polyclonal rabbit antibody and the avidin-biotin-peroxidase complex technique.	Paraffin	34-42	chorionic gonadotropin subunit beta 5	Homo sapiens	14-17
10368636-2	1999	The aim of this study was to detect the protein expression pattern of hMSH2 and hMLH1 in oral squamous cell carcinoma (SCC) by immunohistochemistry in paraffin-embedded tissues.	Paraffin	151-159	mutS homolog 2	Homo sapiens	70-75
8494710-1	1993	Estimation of FGF-3 oncogene amplification in DNA samples extracted from paraffin embedded sections of 136 ovarian cancer samples was carried out by a quantitative PCR method.	Paraffin	73-81	fibroblast growth factor 3	Homo sapiens	14-19
2578846-1	1985	An immunocytochemical method to localise prostate-specific antigen (PSA) in paraffin sections was used to establish the prostatic origin of both primary and metastatic tumours.	Paraffin	76-84	kallikrein related peptidase 3	Homo sapiens	41-72
10217560-6	1999	In both cases, a reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX fusion gene transcripts, which are characteristic of synovial sarcoma.	Paraffin	106-114	synaptotagmin 1	Homo sapiens	141-144
4044303-3	1985	In paraffin sections neuron-specific enolase was demonstrated in all calcitonin-storing parafollicular cells in rats aging 1 to 180 days.	Paraffin	3-11	enolase 2	Rattus norvegicus	21-44
3925619-1	1985	An immunohistochemical investigation of vimentin, an intermediate filament, was carried out on formalin fixed paraffin embedded sections of 44 malignant mesotheliomas of the pleura and 24 pulmonary adenocarcinomas, in order to assess its value in differential diagnosis.	Paraffin	110-118	vimentin	Homo sapiens	40-48
1361526-4	1992	Expression of c-erbB-3 protein was indicated by membrane and/or cytoplasmic tumour cell immunoreactivity in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	124-132	erb-b2 receptor tyrosine kinase 3	Homo sapiens	14-22
1280156-7	1992	An intense immunostaining of the stellate reticulum with anti-bFGF antibodies was also found on paraffin sections from bud to bell stage.	Paraffin	96-104	fibroblast growth factor 2	Mus musculus	62-66
9885226-4	1999	The three antibodies immunostain wild-type NPM (in paraffin-embedded normal tissue samples) in cell nuclei and in the cytoplasm of mitotic cells.	Paraffin	51-59	nucleophosmin 1	Homo sapiens	43-46
1380868-3	1992	The peroxidase anti-peroxidase technique was applied for the immunohistochemical demonstration of NGF using a polyclonal antiserum on Bouin-fixed, paraffin-embedded pineal glands from adult, young and 6-hydroxydopamine (6-OHDA)-treated rats.	Paraffin	147-155	nerve growth factor	Rattus norvegicus	98-101
6355996-1	1983	Different fixatives and immunohistochemical methods were tested for detection of fibronectin in various paraffin embedded tissues: rat kidney, spleen, gastro-intestinal tract, muscle, normal and fibrotic liver and human skin.	Paraffin	104-112	fibronectin 1	Rattus norvegicus	81-92
6353850-1	1983	Immunoperoxidase staining for myoglobin was performed on formalin-fixed, paraffin-embedded tissues of normal human skeletal muscle and rhabdomyosarcomas in order to assess its potential diagnostic value.	Paraffin	73-81	myoglobin	Homo sapiens	30-39
9918259-3	1999	In situ hybridization with digoxigenin labeled RNA probes was applied to investigate MT1-MMP expression in paraffin sections of the samples.	Paraffin	107-115	matrix metallopeptidase 14	Homo sapiens	85-92
6345602-3	1983	In the present studies, a commercially available antiserum to GFA protein incorporated in a peroxidase-antiperoxidase procedure was applied to paraffin sections of brain and spinal cord from mice affected with scrapie, avirulent Semliki forest virus and cuprizone encephalopathy, and to tissues from healthy and scrapie-affected sheep.	Paraffin	143-151	glial fibrillary acidic protein	Mus musculus	62-73
1816072-6	1991	Furthermore immunohistochemical studies on selected frozen and paraffin embedded tissues with mAb M-Kid 2 have provided staining pattern indicating the recognition of Vla-3.	Paraffin	63-71	zinc finger protein 354B	Homo sapiens	100-105
9926866-1	1998	BcL-xL and Bcl-2 proteins were identified by paraffin section immunohistochemistry in the neuropil core of the barrelettes of the caudalis spinal trigeminal nucleus 6 h after birth.	Paraffin	45-53	BCL2-like 1	Mus musculus	0-6
1712544-6	1991	These results suggest that the PR-ICA is an effective tool in the evaluation of PR content in breast cancer and can be applied in paraffin as well as frozen sections.	Paraffin	130-138	progesterone receptor	Homo sapiens	31-33
9846986-3	1998	In the current study performed on paraffin-embedded tissue, cyclin D1 mRNA could be detected in 23 of 24 mantle-cell lymphomas by reverse transcription polymerase chain reaction (RT-PCR) whereas only 9 of 24 demonstrated a t(11;14) by PCR.	Paraffin	34-42	cyclin D1	Homo sapiens	60-69
6291659-1	1982	The interaction of cytochrome c with a paraffin-wax-impregnated spectroscopic graphite electrode (WISGE) was studied in a medium consisting of 0.1 M potassium phosphate, pH 7.0, by means of differential pulse and cyclic voltammetry.	Paraffin	39-47	cytochrome c, somatic	Equus caballus	19-31
7198503-3	1982	In order to investigate this further, an NCA in the capsule of a nontumorous axillary lymph node obtained from a patient with breast cancer was removed from a paraffin block and processed for electron microscopic study.	Paraffin	159-167	CEA cell adhesion molecule 6	Homo sapiens	41-44
1958256-5	1991	The specific staining for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin and frozen sections.	Paraffin	99-107	progesterone receptor	Homo sapiens	33-35
1958256-5	1991	The specific staining for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin and frozen sections.	Paraffin	99-107	progesterone receptor	Homo sapiens	119-121
1958256-5	1991	The specific staining for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin and frozen sections.	Paraffin	185-193	progesterone receptor	Homo sapiens	33-35
9846986-8	1998	This assay for cyclin D1 expression, designed for formalin-fixed, paraffin-embedded tissue, was a very sensitive and specific marker for mantle-cell lymphoma.	Paraffin	66-74	cyclin D1	Homo sapiens	15-24
9888669-6	1998	This immunohistochemical test for nm23 is easily performed on standard paraffin sections and is recommended as an accurate prognostic marker for giant cell tumours of tendon sheath.	Paraffin	71-79	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	34-38
1958256-5	1991	The specific staining for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin for ER and PR were exclusively located in the nuclei of cancer cells in both paraffin and frozen sections.	Paraffin	185-193	progesterone receptor	Homo sapiens	119-121
7015823-1	1981	Hemoglobin and myoglobin have been identified in formalin-fixed paraffin-embedded sections of human autopsy material with the indirect fluorescent antibody technic.	Paraffin	64-72	myoglobin	Homo sapiens	15-24
339969-2	1977	This contrast allows accurate identification of fluorescent CSF cells and structures in formalin fixed paraffin embedded brain tissues; in the latter, the combined optical procedure is fruitfull in order to avoid fluorescent artifacts misinterpretation.	Paraffin	103-111	colony stimulating factor 2	Homo sapiens	60-63
9823984-3	1998	An immunohistochemical technique was used to evaluate the association between expression of c-erbB3 and clinical parameters and tumour markers such as epidermal growth factor receptor (EGFR), c-erbB2, cathepsin-D and p53 in archival formalin-fixed paraffin-embedded tumour tissues.	Paraffin	248-256	erb-b2 receptor tyrosine kinase 3	Homo sapiens	92-99
33660008-4	2021	METHODS: Expression analysis of SPHK1 was performed on formalin-fixed paraffin-embedded tissue from 1005 ovarian cancer patients with different histological subtypes using immunohistochemistry.	Paraffin	70-78	sphingosine kinase 1	Homo sapiens	32-37
33840146-9	2021	Next-generation sequencing studies (sarcoma gene fusion NGS panel with subsequent Sanger confirmation) performed on formalin-fixed paraffin-embedded tissue detected a fusion product between MEAF6 exon 4 (NM_001270875) and SUZ12 exon 2 (NM_001321207.1).	Paraffin	131-139	MYST/Esa1 associated factor 6	Homo sapiens	190-195
1706556-4	1990	Immunohistochemistry using paraffin sections demonstrated cytokeratin (CK) and epithelial membrane antigen (EMA), generally regarded as epithelial markers, not only in the epithelial component but also in chondrosarcoma cells.	Paraffin	27-35	mucin 1, cell surface associated	Homo sapiens	79-112
9650754-1	1998	Using immunohistochemistry we evaluated the expression of two negative regulators of the cell cycle, the retinoblastoma gene product (pRb) and the WAF1/Cip1 gene product (p21), in consecutive paraffin sections from 54 gliomas (49 astrocytomas and 5 oligodendrogliomas) and related it to clinicopathological parameters, proliferative fraction, p53 expression and survival.	Paraffin	192-200	RB transcriptional corepressor 1	Homo sapiens	134-137
2178530-2	1990	To test whether neutrophils infiltrate and degranulate in areas of chronic respiratory allergic inflammation, we developed an indirect immunofluorescence technique to localize neutrophil elastase in formalin-fixed, paraffin-embedded tissues.	Paraffin	215-223	elastase, neutrophil expressed	Homo sapiens	176-195
9569039-11	1998	Because HGF/SF was previously found in the pleural effusion fluids of patients with malignant mesothelioma and in paraffin-embedded tumour tissues, it is concluded that HGF/SF may well stimulate the growth and spread of malignant mesothelioma in vivo by paracrine and/or autocrine mechanisms.	Paraffin	114-122	hepatocyte growth factor	Homo sapiens	8-14
2079108-0	1990	Enhanced immunocytochemical staining sensitivity in formalin-fixed and paraffin-embedded material by simultaneous use of PAP and ABC.	Paraffin	71-79	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	129-132
2079108-1	1990	The simultaneous use of two immunoperoxidase (IP) methods; e.g. the PAP (Peroxidase-antiperoxidase) and ABC (Avidin-Biotin) to localize a single antigen enhances the sensitivity of polyclonal antibodies (FVIII/RAg and laminin) or monoclonal antibodies (MABs) (against human B-, T-cells and macrophages) in routinely formalin fixed and in paraffin embedded material.	Paraffin	338-346	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	73-107
33086223-7	2021	Immunohistochemical staining for NPY1R was done on paraffin-embedded formalin-fixed tissue sections.	Paraffin	51-59	neuropeptide Y receptor Y1	Homo sapiens	33-38
33631924-6	2021	Proteins of interest, including PRDX2, PRDX6, and Gelsolin, were differentially expressed in chemo-sensitive tumors versus chemo-resistant tissues and these observations were validated by immunohistochemistry in 92 formalin-fixed and paraffin-embedded (FFPE) specimens.	Paraffin	234-242	gelsolin	Homo sapiens	50-58
9569039-11	1998	Because HGF/SF was previously found in the pleural effusion fluids of patients with malignant mesothelioma and in paraffin-embedded tumour tissues, it is concluded that HGF/SF may well stimulate the growth and spread of malignant mesothelioma in vivo by paracrine and/or autocrine mechanisms.	Paraffin	114-122	hepatocyte growth factor	Homo sapiens	169-175
9500772-8	1998	Fluorescence in situ hybridization analysis of paraffin-embedded tissue revealed that three of four tumors were positive for a chromosomal translocation involving the EWS locus at 22q12, seen in more than 90% of cases of Ewing"s sarcoma/malignant primitive neuroectodermal tumor.	Paraffin	47-55	EWS RNA binding protein 1	Homo sapiens	167-170
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Paraffin	115-123	sucrase-isomaltase	Homo sapiens	0-18
32732636-3	2021	Sucrase isomaltase (SI) gene variants were detected by next-generation sequencing (NGS) of DNA from formalin-fixed-paraffin-embedded (FFPE) tissues of these patients.	Paraffin	115-123	sucrase-isomaltase	Homo sapiens	20-22
2197240-4	1990	One of the hybrids secretes a monoclonal antibody of the IgG3 subtype designated FEN-1, which reacts with 100% of endometrioid ovarian cancer containing adenoacanthoma by indirect immunoperoxidase on paraffin-embedded tissue.	Paraffin	200-208	Immunoglobulin heavy constant gamma 3	Mus musculus	57-61
2197240-4	1990	One of the hybrids secretes a monoclonal antibody of the IgG3 subtype designated FEN-1, which reacts with 100% of endometrioid ovarian cancer containing adenoacanthoma by indirect immunoperoxidase on paraffin-embedded tissue.	Paraffin	200-208	flap structure specific endonuclease 1	Mus musculus	81-86
33847943-6	2021	Here we explain the staining process for C1q, C4, and C3 in human paraffin-embedded tumor sections by immunofluorescence and immunohistochemistry.	Paraffin	66-74	complement C1q A chain	Homo sapiens	41-44
9495362-1	1998	The cell cycle-associated retinoblastoma protein (pRb) and p16 protein were demonstrated using immuno-histochemistry on paraffin sections from 192 cases of invasive breast carcinoma.	Paraffin	120-128	RB transcriptional corepressor 1	Homo sapiens	50-53
9868384-7	1998	Different combinations of MAbs were suitable for enzyme immuno assays and two MAbs could be used for immunohistochemical detection of TN in both fresh frozen and paraffin embedded tissues.	Paraffin	162-170	C-type lectin domain family 3 member B	Homo sapiens	134-136
34019287-5	2021	We will also discuss the challenges of detecting phosphorylated c-Myc in formalin-fixed paraffin-embedded tissues by immunofluorescence and describe a protocol using a new rat monoclonal antibody we have generated suitable for this purpose.	Paraffin	88-96	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	64-69
34019299-0	2021	Chromogenic In Situ Hybridization (CISH) as a Method for Detection of C-Myc Amplification in Formalin-Fixed Paraffin-Embedded Tumor Tissue: An Update.	Paraffin	108-116	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	70-75
9398748-3	1997	To this end, expression of StAR was detected in formalin-fixed, paraffin-embedded specimens using a polyclonal antiserum raised against recombinant human StAR.	Paraffin	64-72	steroidogenic acute regulatory protein	Homo sapiens	27-31
33256302-2	2020	Methods: The expression of PRDX1 protein was detected by immunohistochemistry (IHC) in 70 paraffin specimens of cancer and normal mucosa adjacent to gastric cancer, and the relationship between PRDX1 protein and clinicopathological characteristics was analyzed.	Paraffin	90-98	peroxiredoxin 1	Homo sapiens	27-32
33775850-0	2021	Profilin 3 genetic architecture in glioma formalin fixed paraffin embedded (FFPE) archive.	Paraffin	57-65	profilin 3	Homo sapiens	0-10
33778077-5	2021	Herein, we analyzed MMP2 mRNA expression level in cholesteatoma using RNA-in situ hybridization in formalin-fixed, paraffin-embedded (FFPE) tissue samples.	Paraffin	115-123	matrix metallopeptidase 2	Homo sapiens	20-24
33245030-5	2020	Semiquantitative gene expression for MACC1 was evaluated using formalin-fixed paraffin-embedded sections and unfixed tumour samples from primary Rb cases (n = 44).	Paraffin	78-86	MET transcriptional regulator MACC1	Homo sapiens	37-42
9390038-3	1997	This study describes the generation and characterisation of two novel murine monoclonal antibodies recognizing ER and PgR, designated NCL-ER-6F11 and NCL-PGR respectively, which are effective in heat-treated formalin-fixed, paraffin-embedded tissue.	Paraffin	224-232	progesterone receptor	Homo sapiens	118-121
32307573-5	2020	CTNNB1-PLAG1 gene fusion was identified by reverse transcription-polymerase chain reaction using formalin-fixed paraffin-embedded tissue (FFPE).	Paraffin	112-120	catenin beta 1	Homo sapiens	0-6
9390038-3	1997	This study describes the generation and characterisation of two novel murine monoclonal antibodies recognizing ER and PgR, designated NCL-ER-6F11 and NCL-PGR respectively, which are effective in heat-treated formalin-fixed, paraffin-embedded tissue.	Paraffin	224-232	progesterone receptor	Homo sapiens	154-157
33590909-8	2021	CLDN18.1 and CLDN18.2 expression was validated by reverse transcription-PCR in paraffin-embedded CRC tissues.	Paraffin	79-87	claudin 18	Homo sapiens	0-6
9310947-1	1997	We used a new antibody (NCL-CD5-4C7) immunoreactive for CD5-positive cells in paraffin-embedded tissue, with the microwave antigen retrieval method, to analyze a number of well-characterized cases of B-cell and T-cell non-Hodgkin"s lymphomas whose CD5 immunoreactivity was documented by immunohistochemical analysis performed on frozen sections and/or flow cytometric immunophenotypic analysis of neoplastic cell suspensions.	Paraffin	78-86	nucleolin	Homo sapiens	24-27
33590909-8	2021	CLDN18.1 and CLDN18.2 expression was validated by reverse transcription-PCR in paraffin-embedded CRC tissues.	Paraffin	79-87	claudin 18	Homo sapiens	13-19
32887625-0	2020	Mass spectrometry-based analysis of formalin-fixed, paraffin-embedded distal cholangiocarcinoma identifies stromal thrombospondin-2 as a potential prognostic marker.	Paraffin	52-60	thrombospondin 2	Homo sapiens	115-131
9310947-6	1997	CD5 antibody NCL-CD5-4C7 should be useful for the routine characterization of suspected T-cell and B-cell lymphoproliferative disorders when only paraffin-embedded tissue is available for immunophenotypic analysis.	Paraffin	146-154	nucleolin	Homo sapiens	13-16
10583923-3	1999	The authors" series of 26 small B-cell lymphomas, analyzed for the cyclin D1 protein by paraffin immunohistochemistry and for t(11;14) by polymerase chain reaction, is included.	Paraffin	88-96	cyclin D1	Homo sapiens	67-76
9310957-0	1997	Cyclin D1 protein in multiple myeloma and plasmacytoma: an immunohistochemical study using fixed, paraffin-embedded tissue sections.	Paraffin	98-106	cyclin D1	Homo sapiens	0-9
9310957-1	1997	In this study, we analyzed 69 plasma cell neoplasms, including 54 multiple myelomas (MMs), 3 cases of plasma cell leukemia, and 12 plasmacytomas, for expression of cyclin D1 protein using an immuno-histochemical method applied to routinely fixed, paraffin-embedded tissue sections.	Paraffin	247-255	cyclin D1	Homo sapiens	164-173
9252696-2	1997	MATERIALS AND METHOD: The expression of the protease CatD was evaluated using an immunohistochemical technique with a polyclonal antibody on paraffin-embedded tissue from 80 women treated for invasive ductal mammary carcinoma not otherwise specified (NOS).	Paraffin	141-149	cathepsin D	Homo sapiens	53-57
32333728-12	2020	Indeed, delays in tissue processing and paraffin embedding may lead to sub-optimal performance of PD-L1 staining on CBs.	Paraffin	40-48	CD274 molecule	Homo sapiens	98-103
34300932-7	2021	Besides, the examinations of UV-vis and TGA showed that the paraffin@SiO2 colored microcapsules exhibited good thermal reliability, thermal stability, and UV protection property.	Paraffin	60-68	T-box transcription factor 1	Homo sapiens	40-43
9282199-2	1997	Overexpression of cyclin D1 was detected immunohistochemically using DCS6 monoclonal antibody on formalin-fixed, paraffin-embedded tissue sections.	Paraffin	113-121	cyclin D1	Homo sapiens	18-27
34298614-2	2021	To clarify the potential of AKR1B1 and AKR1B10 as tissue biomarkers of endometrial cancer, we evaluated the immunohistochemical levels of AKR1B1 and AKR1B10 in tissue paraffin sections from 101 well-characterized patients with endometrioid endometrial cancer and 12 patients with serous endometrial cancer and compared them with the clinicopathological data.	Paraffin	167-175	aldo-keto reductase family 1 member B10	Homo sapiens	149-156
32404253-2	2020	STUDY DESIGN: Mutations in promoter region of the TERT gene were analyzed with polymerase chain reaction-based direct sequencing method using formalin-fixed, paraffin-embedded tumor samples of 189 HNSCCs.	Paraffin	158-166	telomerase reverse transcriptase	Homo sapiens	50-54
9140312-2	1997	DESIGN, SETTING, AND PATIENTS: Macrophage migration inhibitory factor was demonstrated by immunocytochemistry on paraffin sections with a polyclonal antirecombinant murine MIF using the streptavidin-biotin-peroxidase complex method.	Paraffin	113-121	macrophage migration inhibitory factor	Homo sapiens	31-69
32498288-3	2020	RUNX1 protein levels were analyzed using immunohistochemistry of formalin-fixed paraffin-embedded tissues from 409 NSCLC patients.	Paraffin	80-88	RUNX family transcription factor 1	Homo sapiens	0-5
34179706-9	2021	Results: The levels of DCX and CRABP2 were confirmed to be remarkably different between paraffin-embedded ARMS and ERMS tissues, while EGFR abundance was only marginally different between these two RMS subtypes.	Paraffin	88-96	doublecortin	Homo sapiens	23-26
35064378-2	2022	Paraffin tissues from patients with OLP, OLK, and OSCC were collected, and the expression of IL-27 in the above tissues was detected by immunohistochemical (IHC) staining.	Paraffin	0-8	interleukin 27	Homo sapiens	93-98
9196441-2	1997	This paper describes the development of two new antisera to APC (to amino- and carboxy-terminal epitopes) which permit localization of the protein by immunohistochemistry in archival paraffin sections.	Paraffin	183-191	APC regulator of WNT signaling pathway	Homo sapiens	60-63
31987601-2	2020	MATERIALS AND METHODS: PD-L1 expression in paraffin-embedded tissues of ovarian cancer was detected by immunohistochemistry (IHC).	Paraffin	43-51	CD274 molecule	Homo sapiens	23-28
9137425-4	1997	In view of theories that most ovarian carcinomas are derived from the OSE cells in aging women, the PS1 antibody has been used to evaluate ovarian tumors using immunocytochemistry to detect the PS1 antigen in paraffin embedded pathology tissues.	Paraffin	209-217	presenilin 1	Homo sapiens	194-197
31489594-6	2020	Expression of TLR 4, 7, 8, and 9 was assessed using immunohistochemical staining of paraffin-embedded renal-biopsy tissue specimens with specific antibodies and evaluated semiquantitatively by light microscopy.	Paraffin	84-92	toll like receptor 4	Homo sapiens	14-19
35569037-4	2022	We assessed the miR-202 expression in paraffin embedded tissue samples collected form an abattoir using in situ hybridisation.	Paraffin	38-46	microRNA 202	Bos taurus	16-23
9074813-5	1997	Several combinations of MAbs were suitable for TN-ELISA and two MAbs could be used for immunohistochemical detection of TN in both fresh frozen and paraffin-embedded tissues.	Paraffin	148-156	C-type lectin domain family 3 member B	Homo sapiens	120-122
35574028-4	2022	We observed and quantified the expression of apelin, SDHB, CHGB, ERBB-2, CNTN4, and SUCLG2 in paraffin-embedded samples using immunohistochemical staining.	Paraffin	94-102	chromogranin B	Homo sapiens	59-63
35203212-5	2022	The present study first compared the expression patterns of legumain in paraffin-embedded canine tumor tissues, with those of normal tissues, by immunohistochemistry.	Paraffin	72-80	legumain	Canis lupus familiaris	60-68
31499585-9	2020	Immunohistochemical analyses of paraffin-embedded BLCA tissue slides confirmed that PML protein expression was decreased in BLCA tumor cells compared with adjacent noncancerous epithelial cells.	Paraffin	32-40	PML nuclear body scaffold	Homo sapiens	84-87
10072845-2	1997	METHODS: Using the RT-PCR and in situ hybridization (ISH) techniques, the expression of B7.1 molecule in 12 fresh and 23 paraffin embedded tissues were studied.	Paraffin	121-129	CD80 molecule	Homo sapiens	88-92
32033262-5	2020	Expression of the adhesion integrin alpha7 (ITGA7) was significantly higher in the GS group, as seen by RT-qPCR (p = 0.00188) and immunohistochemistry of bone marrow formalin-fixed, paraffin-embedded (FFPE) specimens.	Paraffin	182-190	integrin subunit alpha 7	Homo sapiens	27-42
32033262-5	2020	Expression of the adhesion integrin alpha7 (ITGA7) was significantly higher in the GS group, as seen by RT-qPCR (p = 0.00188) and immunohistochemistry of bone marrow formalin-fixed, paraffin-embedded (FFPE) specimens.	Paraffin	182-190	integrin subunit alpha 7	Homo sapiens	44-49
9017235-2	1996	In 10% formalin-fixed paraffin-embedded tissue sections of five hypothalami, TRH mRNA-containing cells were found in several nuclei and areas.	Paraffin	22-30	thyrotropin releasing hormone	Homo sapiens	77-80
8952530-3	1996	We studied the expression and distribution of CD40 in paraffin sections of 71 uniformly treated malignant melanomas (MMs) with a long clinical follow-up using well known monoclonal antibodies.	Paraffin	54-62	CD40 molecule	Homo sapiens	46-50
32213157-5	2020	The number of Slit2 and Robo1 positive cells in the serial sections of muscle paraffin tissues was measured by immunohistochemistry in 10 patients with PM, 10 patients with DM and 20 healthy controls.	Paraffin	78-86	slit guidance ligand 2	Homo sapiens	14-19
32213157-5	2020	The number of Slit2 and Robo1 positive cells in the serial sections of muscle paraffin tissues was measured by immunohistochemistry in 10 patients with PM, 10 patients with DM and 20 healthy controls.	Paraffin	78-86	roundabout guidance receptor 1	Homo sapiens	24-29
9042261-6	1996	The immunohistochemical assay of formalin-fixed paraffin-embedded sections allows the retrospective analysis of ER and PgR in NSCLC.	Paraffin	48-56	progesterone receptor	Homo sapiens	119-122
31605792-6	2020	RESULTS: PD-L1 staining was successful in 193 of 197 patient formalin-fixed paraffin-embedded blocks; of these, 128 of 193 were EGFRm-positive and 106 of 128 patients were randomized to treatment (osimertinib: 54; comparator: 52).	Paraffin	76-84	CD274 molecule	Homo sapiens	9-14
31939170-2	2020	The described protocol has been optimized for IL-1 detection in formalin-fixed, paraffin-embedded oral tissue sections by light microscopy.	Paraffin	80-88	interleukin 1 alpha	Homo sapiens	46-50
8895729-3	1996	In this study, we have examined the protein expression pattern of hMSH2 and hMLH1 by immunohistochemistry in paraffin-embedded tumors from 7 patients with MIN+ sporadic cancer, 13 patients with familial colorectal cancer, and 12 patients meeting the strict Amsterdam criteria for hereditary nonpolyposis colon cancer.	Paraffin	109-117	mutS homolog 2	Homo sapiens	66-71
31185430-0	2019	Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor alpha (PPARalpha).	Paraffin	24-33	peroxisome proliferator activated receptor alpha	Rattus norvegicus	122-170
31185430-0	2019	Short-chain chlorinated paraffins (SCCPs) disrupt hepatic fatty acid metabolism in liver of male rat via interacting with peroxisome proliferator-activated receptor alpha (PPARalpha).	Paraffin	24-33	peroxisome proliferator activated receptor alpha	Rattus norvegicus	172-181
8816596-3	1996	Recently, a new monoclonal antibody to CD5, NCL-CD5, has been introduced that detects CD5 in paraffin-embedded tissues.	Paraffin	93-101	nucleolin	Homo sapiens	44-47
8816596-12	1996	Although NCL-CD5 does indeed stain reactive T cells in paraffin sections, it does not appear to stain neoplastic CD5+ cells.	Paraffin	55-63	nucleolin	Homo sapiens	9-12
8764748-4	1996	In the present study, we immunohistochemically investigated the PRAD1/cyclin D1 protein in a large series of 334 lymphoproliferative disorders, including 39 cases of MCLs on paraffin sections.	Paraffin	174-182	cyclin D1	Homo sapiens	64-69
29517505-8	2019	H-41 works well in immunohistochemistry on paraffin-embedded tissue and comparison with previously stained cases, shows superior immunolabeling to mAb g3.20.	Paraffin	43-51	CDV3 homolog	Homo sapiens	0-4
31357093-5	2019	MYC protein expression level was assessed by immunohistochemistry (IHC) staining using paraffin-embedded BM trephine biopsy samples obtained at the time of diagnosis or relapse.	Paraffin	87-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-3
9021682-7	1996	When paraffin sections of 105 cases of ALCL were stained using the anti-p80 antibody, 30 were shown to be p80 positive Clinicopathological comparison between p80-positive and p80-negative ALCLs revealed that the p80-positive cases occurred in a much younger patient age group and that the patients showed a far better 5-year survival rate.	Paraffin	5-13	coilin	Homo sapiens	106-109
31367630-9	2019	DNA sequencing performed on paraffin-embedded tissue revealed two exactly coincident alterations in CDH1, C.57T&gt;G and C.1418A&gt;T. CONCLUSION: This case suggests that the combination of CDH1 mutations and WNT/beta-catenin signaling activation contributes to the carcinogenesis of gastrointestinal SMPC.	Paraffin	28-36	catenin beta 1	Homo sapiens	213-225
9021682-7	1996	When paraffin sections of 105 cases of ALCL were stained using the anti-p80 antibody, 30 were shown to be p80 positive Clinicopathological comparison between p80-positive and p80-negative ALCLs revealed that the p80-positive cases occurred in a much younger patient age group and that the patients showed a far better 5-year survival rate.	Paraffin	5-13	coilin	Homo sapiens	106-109
9021682-7	1996	When paraffin sections of 105 cases of ALCL were stained using the anti-p80 antibody, 30 were shown to be p80 positive Clinicopathological comparison between p80-positive and p80-negative ALCLs revealed that the p80-positive cases occurred in a much younger patient age group and that the patients showed a far better 5-year survival rate.	Paraffin	5-13	coilin	Homo sapiens	106-109
8698319-2	1996	We applied immunohistochemistry using the avidin-biotin-complex technique to examine the presence of parathyroid hormone-related protein (PTHrP) in formalin-fixed and paraffin-embedded sections of tissue from a case of sclerosing hepatic carcinoma obtained at autopsy.	Paraffin	167-175	parathyroid hormone like hormone	Homo sapiens	138-143
31220107-6	2019	eEF1A2 protein level was measured in formalin-fixed paraffin-embedded tissues by immunohistochemistry in a semi-quantitative manner (sum of the percentage of positive cells x staining intensity) on a scale from 0 to 300.	Paraffin	52-60	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	0-6
8740788-4	1996	Recent studies showed that overexpression of the cyclin D1 protein can be easily detected by immunohistochemistry (IHC) on formalin-fixed, paraffin embedded tissues.	Paraffin	139-147	cyclin D1	Homo sapiens	49-58
31194830-0	2019	Development of novel monoclonal antibodies with specific binding affinity for denatured human CD26 in formalin-fixed paraffin-embedded and decalcified specimens.	Paraffin	117-125	dipeptidyl peptidase 4	Homo sapiens	94-98
31194830-3	2019	The development of an anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in formalin-fixed paraffin-embedded (FFPE) tissues in the clinical setting is therefore of the utmost importance.	Paraffin	125-133	dipeptidyl peptidase 4	Homo sapiens	33-37
31194830-3	2019	The development of an anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in formalin-fixed paraffin-embedded (FFPE) tissues in the clinical setting is therefore of the utmost importance.	Paraffin	125-133	dipeptidyl peptidase 4	Homo sapiens	93-97
8833089-4	1996	Immunohistochemical analyses with an affinity-purified rabbit anti-PLP(200-219) antiserum demonstrated antibody cross-reactivity with PLP in both paraffin- and gelatin-embedded brain sections and immunocytochemical staining of mouse oligodendrocyte-enriched cultures demonstrated antibody binding with native PLP in situ.	Paraffin	146-154	proteolipid protein (myelin) 1	Mus musculus	67-70
31081047-4	2019	To investigate the role of FOXA1 in the progression of human colorectal cancer, an immunohistochemical technique was used to localize FOXA1 protein in paraffin-embedded tissue blocks obtained from 403 patients with colorectal cancer.	Paraffin	151-159	forkhead box A1	Homo sapiens	134-139
8833089-4	1996	Immunohistochemical analyses with an affinity-purified rabbit anti-PLP(200-219) antiserum demonstrated antibody cross-reactivity with PLP in both paraffin- and gelatin-embedded brain sections and immunocytochemical staining of mouse oligodendrocyte-enriched cultures demonstrated antibody binding with native PLP in situ.	Paraffin	146-154	proteolipid protein (myelin) 1	Mus musculus	134-137
29862664-6	2019	Immunohistochemical staining of PD-L1 was performed on slides containing SC embedded in paraffin wax.	Paraffin	88-100	CD274 molecule	Homo sapiens	32-37
8833089-4	1996	Immunohistochemical analyses with an affinity-purified rabbit anti-PLP(200-219) antiserum demonstrated antibody cross-reactivity with PLP in both paraffin- and gelatin-embedded brain sections and immunocytochemical staining of mouse oligodendrocyte-enriched cultures demonstrated antibody binding with native PLP in situ.	Paraffin	146-154	proteolipid protein (myelin) 1	Mus musculus	134-137
8929865-4	1996	The streptavidin-biotin immunoperoxidase method, applied to paraffin-embedded specimens from 39 fetuses ranging from 10 to 41 wk, showed that TGF-alpha, EGF, and EGF receptor exhibited a similar cellular distribution during the whole period of gestation.	Paraffin	60-68	transforming growth factor alpha	Homo sapiens	142-151
31030490-1	2019	Methods: Records of 132 women with EOC were reviewed.Immunostaining of PD-L1 was performed with formalin-fixed, paraffin-embedded specimens.	Paraffin	112-120	CD274 molecule	Homo sapiens	71-76
8625227-12	1996	Paraffin-section immunostaining showed positive reactions for epithelial membrane antigen (100%), keratin (AE1/AE3) (88%), alpha-lactalbumin (88%), GCDFP-15 (76%), and carcinoembryonic antigen (72%); S-100 protein was rarely detected (4%).	Paraffin	0-8	solute carrier family 4 member 1 (Diego blood group)	Homo sapiens	107-114
8720458-2	1996	The binding of a mouse monoclonal antibody (MEP-1) reacting specifically with type I pneumocytes was assessed on paraffin sections of normal specimens as well as those with pulmonary fibrosis induced by bleomycin or radiation treatment.	Paraffin	113-121	meprin A subunit alpha	Rattus norvegicus	44-49
31061899-1	2019	Sensitive and specific monoclonal antibodies (mAbs) targeting podoplanin (PDPN) are needed for immunohistochemical analyses using formalin-fixed paraffin-embedded tissues because PDPN is known as a lymphatic endothelial cell maker in pathology.	Paraffin	145-153	podoplanin	Cricetulus griseus	74-78
7670110-5	1995	We developed an immunohistochemical assay to detect overexpression of the cyclin D1 protein on conventional formalin-fixed, paraffin-embedded biopsies using the well-defined monoclonal antibody DCS-6.	Paraffin	124-132	cyclin D1	Homo sapiens	74-83
29135534-1	2019	Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy.	Paraffin	172-180	CD274 molecule	Homo sapiens	50-80
29135534-1	2019	Preliminary data suggest that tumor expression of programmed cell death ligand 1 (PD-L1) protein in human cancers, as determined by immunohistochemistry in formalin-fixed, paraffin-embedded tissue samples, may predict clinical response to anti-PD-1/PD-L1 therapy.	Paraffin	172-180	CD274 molecule	Homo sapiens	82-87
7670110-13	1995	Detection of cyclin D1 overexpression on formalin-fixed, paraffin-embedded tissues using the DCS-6 monoclonal antibody can be applied for routine diagnostic purposes.	Paraffin	57-65	cyclin D1	Homo sapiens	13-22
29135534-3	2019	The aim of the current study was to examine PD-L1 expression in formalin-fixed, paraffin-embedded malignant and nonmalignant cells from human tumors to establish potential characteristic patterns of PD-L1 expression in tumor tissues.	Paraffin	80-88	CD274 molecule	Homo sapiens	44-49
7750938-0	1995	Expression of the monomeric 67-kd laminin-binding protein in human lymphomas as defined by MLuC5 monoclonal antibody and paraffin section immunohistochemistry.	Paraffin	121-129	galectin 3	Homo sapiens	34-57
30915272-5	2019	Methods: Co-expression of CK8 and Vim was evaluated by immunofluorescence (IF) on paraffin-embedded tissue sections of 122 patients with PCa who underwent radical prostatectomies between 1998 and 2016 at the American University of Beirut Medical Center (AUBMC).	Paraffin	82-90	vimentin	Homo sapiens	34-37
30414134-0	2019	Immunofluorescent Visualization of BMP Signaling Activation on Paraffin-Embedded Tissue Sections.	Paraffin	63-71	bone morphogenetic protein 1	Homo sapiens	35-38
7769847-2	1995	The IgH-CDR3 sequences were amplified using DNA extracted from clinical specimens (bone marrow, peripheral blood and fresh-frozen or paraffin-embedded lymph nodes) by a semi-nested PCR with consensus primers directed to conserved regions within the variable (VH) and the joining (JH) gene segments.	Paraffin	133-141	immunoglobulin heavy constant delta	Homo sapiens	4-7
30618794-7	2018	Immunofluorescence was used to investigate the expression of OPN in paraffin-embedded heart sections co-stained with the myocyte markers Actin Alpha 1 (ACTA1) and Myosin Light Chain 2 (MLC2).	Paraffin	68-76	secreted phosphoprotein 1	Homo sapiens	61-64
16695980-3	1995	CD40 ligand expression was not shown in HRS cells but was confined to a subset of small lymphocytes some of which were seen to be in intimate contact with HRS cells.Paraffin wax sections from a further 60 cases of Hodgkin"s disease were examined for CD40 and EBER expression alone.	Paraffin	165-177	CD40 molecule	Homo sapiens	0-4
30464513-9	2018	Furthermore, immunohistochemical analysis revealed an increased level of ACADL protein expression in all 135 paraffin-embedded samples from ESCC patients, which increased with disease progression.	Paraffin	109-117	acyl-CoA dehydrogenase long chain	Homo sapiens	73-78
7867006-2	1995	Overexpression of cyclin D1 was detected immunohistochemically using an affinity-purified polyclonal antibody directed against the carboxyl-terminal part of the cyclin D1 protein, applied to formalin-fixed, paraffin-embedded tissue sections.	Paraffin	207-215	cyclin D1	Homo sapiens	18-27
30774681-4	2018	Methods: We performed chromogenic in situ hybridization (CISH) to detect the sub-cellular localization of miR-21 in 25 formalin-fixed, paraffin-embedded (FFPE) samples of WT.	Paraffin	135-143	microRNA 21	Homo sapiens	106-112
7780691-2	1995	Cathepsin D expression was determined by immunohistochemistry in 445 formalin fixed, paraffin embedded primary invasive breast carcinomas.	Paraffin	85-93	cathepsin D	Homo sapiens	0-11
30004048-3	2018	Methods: HE4 expressions were studied in 242 formalin-fixed, paraffin-embedded breast carcinoma specimens and their association with different pathological and clinical parameters was evaluated.	Paraffin	61-69	WAP four-disulfide core domain 2	Homo sapiens	9-12
7531681-1	1994	Immunohistochemical expression of PRAD1/cyclin D1 protein has been investigated in 106 tissue specimens of 104 cases of lymphoma, non-neoplastic lymphoid disorders and other hematologic malignancies by employing the monoclonal antibody 5D4 with formalin-fixed paraffin-embedded sections, using the microwave oven heating method.	Paraffin	260-268	cyclin D1	Homo sapiens	34-39
29731880-3	2018	TARBP1 protein expression was analyzed in 90 paraffin-embedded NSCLC tissue samples and paired adjacent normal tissues by immunohistochemistry.	Paraffin	45-53	TAR (HIV-1) RNA binding protein 1	Homo sapiens	0-6
29731880-6	2018	In the paraffin-embedded tissue samples, the expression level of TARBP1 was higher in the cancer tissues than in the adjacent non-cancerous tissues.	Paraffin	7-15	TAR (HIV-1) RNA binding protein 1	Homo sapiens	65-71
7970501-3	1994	In the present study, we used an immunohistochemical technique with a monoclonal antibody raised against RB protein (PMG3-245) to detect its expression in representative paraffin sections of tissues obtained from 108 patients with various types of lung cancer treated by surgical resection of the primary tumor.	Paraffin	170-178	RB transcriptional corepressor 1	Homo sapiens	105-107
29491064-0	2018	Reduced Tumour Proportion Scores for Programmed Cell Death Ligand 1 in Stored Paraffin Tissue Sections.	Paraffin	78-86	CD274 molecule	Homo sapiens	37-67
7518196-7	1994	Nuclear cyclin D1 protein can be detected in all cases of MCL and in rare cases of B-SLL/CLL using an immunohistochemical technique on formalin-fixed, paraffin-embedded tissue, and it does not appear to be detectable in reactive hyperplasias and other low-grade B-cell lymphomas.	Paraffin	151-159	cyclin D1	Homo sapiens	8-17
29148098-3	2018	METHODS: We investigated the presence and localization of dynein axonemal heavy chain 5 (DNAH5) in motile cilia using immunofluorescence staining in paraffin-embedded nasal biopsies from NPs (n = 120) and inferior turbinate mucosa (n = 35) of healthy controls.	Paraffin	149-157	dynein axonemal heavy chain 5	Homo sapiens	58-87
29148098-3	2018	METHODS: We investigated the presence and localization of dynein axonemal heavy chain 5 (DNAH5) in motile cilia using immunofluorescence staining in paraffin-embedded nasal biopsies from NPs (n = 120) and inferior turbinate mucosa (n = 35) of healthy controls.	Paraffin	149-157	dynein axonemal heavy chain 5	Homo sapiens	89-94
7960940-1	1994	The objective of our study was to determine the cellular localisation of glucose-6-phosphatase in developing human kidney using monospecific antiserum and a standard immunohistochemical method (peroxidase-antiperoxidase, PAP) on formalin fixed and paraffin embedded tissue.	Paraffin	248-256	glucose-6-phosphatase catalytic subunit 1	Homo sapiens	73-94
28719380-2	2018	Preliminary data suggest that its detection using immunohistochemistry (IHC) in formalin-fixed and paraffin-embedded tissues may predict clinical response to PD-1/PD-L1 therapy.	Paraffin	99-107	CD274 molecule	Homo sapiens	163-168
29434930-5	2018	In the present retrospective study, using archived paraffin-embedded tissue blocks, the local production of hepcidin by immunohistochemical analysis was detected, and then its correlation with clinicopathological characteristics in human gastric cancer was evaluated.	Paraffin	51-59	hepcidin antimicrobial peptide	Homo sapiens	108-116
8021783-2	1994	In the index cases the deficiency of SP-B was associated with qualitative and quantitative abnormalities of the surfactant proteins A and C. Immunostaining for lung surfactant proteins and a search for the 121ins2 mutation by restriction enzyme analysis of DNA extracted from paraffin-embedded lung tissue was performed for 7 additional affected infants from 6 families, bringing to 10 the total number of patients with CAP who have been studied.	Paraffin	276-284	surfactant protein B	Homo sapiens	37-41
8205533-14	1994	In addition, trypsinized paraffin-embedded liver sections from PB-treated rats exhibited diffuse cytoplasmic Cx32 staining that was restricted to centrolobular cells.	Paraffin	25-33	gap junction protein, beta 1	Rattus norvegicus	109-113
29397833-0	2018	[C-MYC Gene and Protein Expression in Paraffin Wax of T Lymphoblastic Lymphoma and Leukemia Patients and Its Effect on the Prognosis].	Paraffin	38-50	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	1-6
8195927-2	1994	In an attempt to elucidate the potential role of cyclin D1 (a gene located within the 11q13 amplicon and a candidate BCL-1, PRAD-1 oncogene) in the pathogenesis of human neoplasias, we have developed and characterized a novel monoclonal antibody specifically recognizing cyclin D1 protein in various assays including immunohistochemistry on frozen and paraffin sections.	Paraffin	352-360	cyclin D1	Homo sapiens	49-58
7911817-1	1994	The immunohistochemical determination of the accessory protein of DNA-polymerase delta (PCNA), a marker of an early S-phase of the cell cycle, was used to evaluate cell proliferation retrospectively in formalin-fixed, paraffin-embedded liver biopsy sections in a group of patients with cirrhosis of similar age and duration of follow up, and with no evidence of hepatocellular carcinoma (41), including 17 patients with and 24 without hepatocellular carcinoma appearance during follow up.	Paraffin	218-226	DNA polymerase delta 1, catalytic subunit	Homo sapiens	66-86
29378601-5	2018	The aim of this study was to evaluate the immunohistochemical expression of retinoic acid receptor alpha (RARA) and CRABP2 in paraffin-embedded samples of nephroblastomas via semiquantitative and quantitative analyses and to correlate this expression with prognostic factors.	Paraffin	126-134	retinoic acid receptor alpha	Homo sapiens	76-104
29378601-5	2018	The aim of this study was to evaluate the immunohistochemical expression of retinoic acid receptor alpha (RARA) and CRABP2 in paraffin-embedded samples of nephroblastomas via semiquantitative and quantitative analyses and to correlate this expression with prognostic factors.	Paraffin	126-134	retinoic acid receptor alpha	Homo sapiens	106-110
29181100-4	2017	Immunohistochemical analysis revealed that KIF11 expression was upregulated in 256/268 (95.8%) paraffin-embedded archival breast cancer biopsies.	Paraffin	95-103	kinesin family member 11	Homo sapiens	43-48
8305484-5	1994	Immunochemistry of paraffin sections of fetal membranes, revealed the presence of both SP-A and SP-D in the amniotic epithelium and chorio-decidual layers.	Paraffin	19-27	surfactant protein A1	Homo sapiens	87-91
29099815-6	2017	The expression of Hsp27 and P38MAPK were detected by immunohistochemistry in formalin-fixed paraffin embedded primary tissue specimens.	Paraffin	92-100	heat shock protein family B (small) member 1	Homo sapiens	18-23
8288680-6	1994	Here we describe the successful use of a monoclonal antibody (IF2) for the detection of MDM2 protein in paraffin-embedded tissue from human lung biopsies.	Paraffin	104-112	eukaryotic translation initiation factor 5B	Homo sapiens	62-65
29048628-3	2017	In this study, the protein expression of HO-1 in human gastric cancer was measured by immunohistochemistry on paraffin sections of 89 paired gastric carcinoma tissues and adjacent non-cancer tissues.	Paraffin	110-118	heme oxygenase 1	Homo sapiens	41-45
8003863-2	1994	The immunohistochemical localization of PTHrP was studied in sections of formalin-fixed, paraffin-embedded tissues from 28 breast cancers obtained surgically between 1980 and 1985.	Paraffin	89-97	parathyroid hormone like hormone	Homo sapiens	40-45
28978925-3	2017	FGL2 expression in fresh and 170 archived paraffin-embedded ccRCC tissues was measured by quantitative RT-PCR, western blotting, and immunohistochemitry.	Paraffin	42-50	fibrinogen like 2	Homo sapiens	0-4
8232185-1	1993	The localization of Cu/Zn and Mn superoxide dismutase (SOD), which catalyzes the dismutation of superoxide radicals (O2-) to O2 and H2O2, in various thyroid disorders was studied by an immunohistochemical technique in 20% formalin fixed paraffin embedded thin sections using anti-human Cu/Zn and Mn-SOD antibodies.	Paraffin	237-245	superoxide dismutase 2	Homo sapiens	30-53
8214102-8	1993	Immunohistochemical staining of kidney paraffin sections for EGF immunoreactivity demonstrated staining intensities that paralleled the amount of irEGF in the trypsin-digested CRM fraction, suggesting that the membrane-associated irEGF is the predominant form detected by this technique.	Paraffin	39-47	epidermal growth factor like 1	Rattus norvegicus	61-64
28982849-4	2017	MATERIALS AND METHODS: Sphingosine kinase 1 expression was evaluated using immunohistochemical staining in 110 formalin-fixed, paraffin-embedded papillary thyroid carcinoma tissue samples.	Paraffin	127-135	sphingosine kinase 1	Homo sapiens	23-43
8471433-1	1993	The expression of the protease cathepsin-D has been evaluated using an immunohistochemical technique with a polyclonal antibody in paraffin-embedded tissue from 359 patients treated between the years 1975-1981 for Stage I and II breast cancer.	Paraffin	131-139	cathepsin D	Homo sapiens	31-42
28944330-4	2017	Nuclear and cytoplasmic staining of E2F transcription factor 1 was performed for immunohistochemical analysis on paraffin-embedded and blocked tumor tissue samples of patients.	Paraffin	113-121	E2F transcription factor 1	Homo sapiens	36-62
7686056-1	1993	Described here is an immunohistochemical technique using the commercially available monoclonal progesterone receptor (PR) antibody KD 68 in routinely fixed and paraffin-embedded breast carcinomas and lymph node metastases.	Paraffin	160-168	progesterone receptor	Homo sapiens	95-116
28978000-4	2017	PD-L1 was measured on formalin-fixed, paraffin-embedded tissue sections of RC specimens in all patients (n=61) and in 27 matched metastatic biopsy samples by immunohistochemistry.	Paraffin	38-46	CD274 molecule	Homo sapiens	0-5
7686056-1	1993	Described here is an immunohistochemical technique using the commercially available monoclonal progesterone receptor (PR) antibody KD 68 in routinely fixed and paraffin-embedded breast carcinomas and lymph node metastases.	Paraffin	160-168	progesterone receptor	Homo sapiens	118-120
28137728-2	2017	METHODS: Fusion gene detection using a next-generation sequencing-based anchored multiplex PCR technique (Archer FusionPlex Sarcoma Panel) was used to identify the novel fusion breakpoints of this CIC-DUX4 sarcoma using formalin-fixed and paraffin-embedded tumour material.	Paraffin	239-247	double homeobox 4	Homo sapiens	201-205
8358113-4	1993	nm23 gene product, which shows complete identity to human erythrocyte nucleoside diphosphate kinase, was used to raise an affinity-purified polyclonal antibody Ab-11 which is applicable to formalin-fixed and paraffin-embedded tissues.	Paraffin	208-216	NME/NM23 nucleoside diphosphate kinase 1	Homo sapiens	0-4
28261866-11	2017	In particular, recent discoveries including detection of the BRAFV600E mutation in nearly all cases of HCL and the availability of an antibody to CD103 for use in paraffin-embedded tissues will facilitate the distinction of HCL from other small B cell lymphomas in the nodal/extranodal setting.	Paraffin	163-171	integrin subunit alpha E	Homo sapiens	146-151
1615913-6	1992	It is concluded that quantitative immunocytochemical results for estrogen and progesterone receptor content in formalin-fixed, paraffin-embedded tissue can be generated using image analysis.	Paraffin	127-135	progesterone receptor	Homo sapiens	78-99
28534992-3	2017	In the present study, the expression levels of IDH-1 and HIF-1alpha in 35 formalin-fixed paraffin-embedded sections from osteosarcoma patients were investigated by immunohistochemistry.	Paraffin	89-97	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	47-52
1380026-2	1992	This protein can be localized immunohistochemically in formalin-fixed paraffin-embedded material using a monoclonal antibody NCL-CB11; positive membrane staining correlates with gene amplification and protein overexpression in breast cancer.	Paraffin	70-78	nucleolin	Homo sapiens	125-128
28339008-5	2017	In addition, SNAP25 was detected in a very low number of MB cells as shown by western blot analysis and immunohistochemical analyses of archived and formalin-fixed/paraffin-embedded human MB specimens.	Paraffin	164-172	synaptosome associated protein 25	Homo sapiens	13-19
28363612-4	2017	METHODS: Immunohistochemical staining of PD-L1 expression was performed in sections of 174 Formalin-fixed paraffin-embedded (FFPE) tissue blocks from surgery removed thyroid nodules.	Paraffin	106-114	CD274 molecule	Homo sapiens	41-46
1338641-5	1992	However, only 1 of 17 renal biopsies of IgAN embedded in paraffin was positive for HCMV-DNA.	Paraffin	57-65	IGAN1	Homo sapiens	40-44
28383433-5	2017	In this study, we aimed to determine the clinical relationship between CSCs and TNBC by exploring the expression of aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast CSCs, in TNBC tissues.ALDH1 levels in paraffin-embedded tumor tissues from 158 TNBC patients were evaluated by immunohistochemistry staining using an ALDH1A1 primary antibody.	Paraffin	225-233	aldehyde dehydrogenase 1 family member A1	Homo sapiens	116-140
28383433-5	2017	In this study, we aimed to determine the clinical relationship between CSCs and TNBC by exploring the expression of aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast CSCs, in TNBC tissues.ALDH1 levels in paraffin-embedded tumor tissues from 158 TNBC patients were evaluated by immunohistochemistry staining using an ALDH1A1 primary antibody.	Paraffin	225-233	aldehyde dehydrogenase 1 family member A1	Homo sapiens	142-147
28383433-5	2017	In this study, we aimed to determine the clinical relationship between CSCs and TNBC by exploring the expression of aldehyde dehydrogenase 1 (ALDH1), which is a putative marker of breast CSCs, in TNBC tissues.ALDH1 levels in paraffin-embedded tumor tissues from 158 TNBC patients were evaluated by immunohistochemistry staining using an ALDH1A1 primary antibody.	Paraffin	225-233	aldehyde dehydrogenase 1 family member A1	Homo sapiens	209-214
1466152-1	1992	The occurrence of immunoreactive cystatin C (CC) in normal and neoplastic cells of the human pancreas and gut was investigated using an indirect streptavidin-biotin method on formaldehyde-fixed and paraffin-embedded tissues.	Paraffin	198-206	cystatin C	Homo sapiens	33-43
28454397-4	2017	Therefore, the expression of Sphk1 was examined in 127 formalin-fixed, paraffin-embedded HCC tissues using immunohistochemistry, and its clinical implications and prognostic significance were analyzed.	Paraffin	71-79	sphingosine kinase 1	Homo sapiens	29-34
1466152-1	1992	The occurrence of immunoreactive cystatin C (CC) in normal and neoplastic cells of the human pancreas and gut was investigated using an indirect streptavidin-biotin method on formaldehyde-fixed and paraffin-embedded tissues.	Paraffin	198-206	cystatin C	Homo sapiens	45-47
1756270-6	1991	This method allowed us to determine the ER B genotype of women with ER+ and ER- tumors, starting with minute amounts of DNA from frozen or paraffin embedded tissues.	Paraffin	139-147	estrogen receptor 2	Homo sapiens	40-44
1656695-3	1991	Cytochrome c oxidase in paraffin embedded sections of monkey retinas and optic nerves was examined immunohistochemically using the monoclonal antibody.	Paraffin	24-32	cytochrome c oxidase subunit 6A1, mitochondrial	Bos taurus	0-20
28251919-9	2017	Expression of DCC, UNC5A, and Caspr2 proteins was demonstrated in paraffin-embedded thymoma samples (3) and normal thymus.	Paraffin	66-74	contactin associated protein 2	Homo sapiens	30-36
1991268-1	1991	With a newly developed monoclonal anti-PTHrP antibody, 4B3, the immunohistochemical localization of the parathyroid hormone-related protein (PTHrP) was studied on the formalin-fixed and paraffin-embedded sections of normal human tissues and various subtypes of lung cancer.	Paraffin	186-194	parathyroid hormone like hormone	Homo sapiens	104-139
27667773-5	2017	METHODS: Bristol-Myers Squibb and Dako previously reported on an automated PD-L1 immunohistochemical (IHC) assay that detects cell surface PD-L1 in formalin-fixed, paraffin-embedded, human tumor tissue specimens using Dako"s Autostainer Link 48.	Paraffin	164-172	CD274 molecule	Homo sapiens	75-80
27667773-5	2017	METHODS: Bristol-Myers Squibb and Dako previously reported on an automated PD-L1 immunohistochemical (IHC) assay that detects cell surface PD-L1 in formalin-fixed, paraffin-embedded, human tumor tissue specimens using Dako"s Autostainer Link 48.	Paraffin	164-172	CD274 molecule	Homo sapiens	139-144
28143425-5	2017	Tissue-specific expression of IGFBP-1 and IGF-1 was detected by immunohistochemistry in paraffin-embedded NPC tissues.	Paraffin	88-96	insulin like growth factor binding protein 1	Homo sapiens	30-37
1991268-1	1991	With a newly developed monoclonal anti-PTHrP antibody, 4B3, the immunohistochemical localization of the parathyroid hormone-related protein (PTHrP) was studied on the formalin-fixed and paraffin-embedded sections of normal human tissues and various subtypes of lung cancer.	Paraffin	186-194	parathyroid hormone like hormone	Homo sapiens	141-146
28421449-1	2017	The differences in expression of ERCC1 were estimated between tumor specimens embedded into paraffin blocks and surgical biopsy specimens of non-small cell lung cancer as well as breast and ovarian cancers.	Paraffin	92-100	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	33-38
2085675-5	1990	Using this procedure we were able to visualize 24-kD protein and estrogen receptor or progesterone receptor in individual cells in paraffin sections.	Paraffin	131-139	progesterone receptor	Homo sapiens	86-107
29237908-2	2017	MATERIALS AND METHODS: The expression of EBV was detected using in situ hybridization, and the CK5/6, p63, and p40 expression levels were detected using immunohistochemistry in 45 paraffin-embedded tissues from LEC.	Paraffin	180-188	keratin 5	Homo sapiens	95-100
29237908-3	2017	RESULTS: In 45 paraffin-embedded LEC tissues from 10 different samples, the positive CK5/6 signals were located in the cell membrane.	Paraffin	15-23	keratin 5	Homo sapiens	85-90
2130793-1	1990	An antigen, MAM-6, in human milk-fat globule membranes, was detected with a monoclonal antibody 115D8, in paraffin-embedded sections of 148 cases including human breast cancers and other breast diseases with immunoperoxidase technique.	Paraffin	106-114	mucin 1, cell surface associated	Homo sapiens	12-17
28582870-0	2017	Cutaneous Alpha-Synuclein From Paraffin Embedded Autopsy Specimens in Parkinson"s Disease.	Paraffin	31-39	synuclein alpha	Homo sapiens	10-25
28582870-7	2017	CONCLUSIONS: There is greater deposition of alpha-synuclein within pilomotor, sudomotor and vasomotor nerve fibers of paraffin embedded samples from autopsy confirmed cases of PD compared to control samples.	Paraffin	118-126	synuclein alpha	Homo sapiens	44-59
28582870-8	2017	However, assessment of alpha-synuclein deposition in post-mortem paraffin embedded tissue has many limitations and the utility of this technique in clinical and research studies is uncertain.	Paraffin	65-73	synuclein alpha	Homo sapiens	23-38
27978870-3	2016	METHODS: The expressions of PD-1 and PD-L1 in 20 cases of PC paraffin-embedded tissue specimens were detected through immunohistochemistry.	Paraffin	61-69	CD274 molecule	Homo sapiens	37-42
1973458-0	1990	NCL-CB11, a new monoclonal antibody recognizing the internal domain of the c-erbB-2 oncogene protein effective for use on formalin-fixed, paraffin-embedded tissue.	Paraffin	138-146	nucleolin	Homo sapiens	0-3
2184880-1	1990	We report the use of tumour antigen (TA-4) polyclonal antiserum to assess the level and pattern of TA-4 antigen expression in formalin-fixed paraffin-embedded tissue sections from 110 patients with a range of normal, dysplastic and malignant squamous epithelia from various sites in the upper aerodigestive tract.	Paraffin	141-149	trace amine associated receptor 6	Homo sapiens	99-103
27573466-11	2016	An array-CGH (comparative genome hybridization) and next-generation sequencing analysis of the tumor DNA extracted from the formalin-fixed paraffin-embedded tissue reveals chromosome 6p gain and p.Q209P mutation in the GNAQ gene, respectively, consistent with the diagnosis of intermediate-grade melanocytoma.	Paraffin	139-147	G protein subunit alpha q	Homo sapiens	219-223
2350195-0	1990	Immunohistochemical detection of progesterone receptor in formalin-fixed and paraffin-embedded breast cancer tissue using a monoclonal antibody.	Paraffin	77-85	progesterone receptor	Homo sapiens	33-54
27498289-2	2016	METHODS: We retrospectively analyzed the expression of beta-catenin and cyclin D1 using immunohistochemistry in formalin-fixed paraffin-embedded tissues from 576 patients with early-stage NSCLC.	Paraffin	127-135	catenin beta 1	Homo sapiens	55-67
34433730-5	2021	Detection of granzyme B and CD3 using paraffin sections employed in this study can be a clinically applicable method for detecting CTLs.	Paraffin	38-46	granzyme B	Canis lupus familiaris	13-23
27564404-2	2016	In the present study, we investigated the expression of the PD-1 ligand 1 (PD-L1) in a lymphoma microenvironment using paraffin-embedded tissue samples, and subsequently studied the detailed mechanism of upregulation of PD-L1 on macrophages using cultured human macrophages and lymphoma cell lines.	Paraffin	119-127	CD274 molecule	Homo sapiens	60-73
27564404-2	2016	In the present study, we investigated the expression of the PD-1 ligand 1 (PD-L1) in a lymphoma microenvironment using paraffin-embedded tissue samples, and subsequently studied the detailed mechanism of upregulation of PD-L1 on macrophages using cultured human macrophages and lymphoma cell lines.	Paraffin	119-127	CD274 molecule	Homo sapiens	75-80
27589204-1	2016	Germline PMS2 gene mutations were detected by RT-PCR/direct sequencing of total RNA extracted from puromycin-treated peripheral blood lymphocytes (PBL) and multiplex ligation-dependent probe amplification (MLPA) analyses of Japanese patients with colorectal cancer (CRC) fulfilling either the revised Bethesda Guidelines or being an age at disease onset of younger than 70 years, and screened by mismatch repair protein immunohistochemistry of formalin-fixed paraffin embedded sections.	Paraffin	459-467	PMS1 homolog 2, mismatch repair system component	Homo sapiens	9-13
27781423-6	2016	Interphase fluorescent in situ hybridization (FISH) study on touch preparations from frozen tumor and formaldehyde-fixed, paraffin-embedded histological sections showed amplification of MYC in both PNET-like and gliomatous areas.	Paraffin	122-130	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	186-189
34496167-9	2021	The expression level of Ki-67, CD31 and VEGF were significantly decreased in tumor tissues of the Psoralidin-treated group in comparison with Paraffin-treated group.	Paraffin	142-150	platelet/endothelial cell adhesion molecule 1	Mus musculus	31-35
27244099-5	2016	PCR amplification of the TERT promoter region was performed on DNA extracted from formalin-fixed paraffin-embedded tissue using primers5"-GCCGATTCGACCTCTCTCC-3" (forward) and 5"-CAGCGCTGCCTGAAACTC-3" (reverse).	Paraffin	97-105	telomerase reverse transcriptase	Homo sapiens	25-29
34393539-6	2021	Methods: Immunohistochemistry was used to characterise glypican-6 expression in a panel of archived formalin-fixed, paraffin-embedded colon tissue types.	Paraffin	116-124	glypican 6	Homo sapiens	55-65
27333219-2	2016	This automated IHC assay has been analytically verified and validated using Dako"s autostainer Link 48 and 22C3 mouse anti-PD-L1 monoclonal antibody to detect the PD-L1 expression in formalin-fixed paraffin-embedded human tumor tissue specimens.	Paraffin	198-206	CD274 molecule	Homo sapiens	163-168
34178985-5	2021	Methods: We measured the protein expression of ACE2 in the gastrointestinal tract using immunohistochemical (IHC) staining with an ACE2-specific antibody of paraffin-embedded colon, stomach, liver, and pancreatic tissues.	Paraffin	157-165	angiotensin converting enzyme 2	Homo sapiens	47-51
27056074-3	2016	Here, we studied PD-L1 expression in paraffin-embedded samples from two cohorts of patients with cervical cancer: primary tumor samples from cohort I (squamous cell carcinoma, n=156 and adenocarcinoma, n=49) and primary and paired metastatic tumor samples from cohort II (squamous cell carcinoma, n=96 and adenocarcinoma, n=31).	Paraffin	37-45	CD274 molecule	Homo sapiens	17-22
34178985-5	2021	Methods: We measured the protein expression of ACE2 in the gastrointestinal tract using immunohistochemical (IHC) staining with an ACE2-specific antibody of paraffin-embedded colon, stomach, liver, and pancreatic tissues.	Paraffin	157-165	angiotensin converting enzyme 2	Homo sapiens	131-135
35151910-6	2022	METHODS: Here, we developed 2 quantifications methods to explore BRCA1 and RAD51C promoter methylation in a series of 121 Formalin Fixed-Paraffin-Embedded (FFPE) specimens from resected PA without neoadjuvant treatment.	Paraffin	137-145	RAD51 paralog C	Homo sapiens	75-81
27271609-4	2016	In the present study, microRNA-31 expression was measured in formalin-fixed paraffin-embedded (FFPE) biopsies from 78 patients diagnosed with LARC who were treated with neoadjuvant CRT.	Paraffin	76-84	microRNA 31	Homo sapiens	22-33
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Paraffin	140-148	tetratricopeptide repeat domain 23	Homo sapiens	53-58
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Paraffin	140-148	synaptotagmin 8	Homo sapiens	60-64
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Paraffin	140-148	troponin I2, fast skeletal type	Homo sapiens	65-70
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Paraffin	140-148	castor zinc finger 1	Homo sapiens	75-80
34995373-7	2022	RESULTS: TUBB3 expression was confirmed in 91.6% of paraffin-embedded SCC specimens.	Paraffin	52-60	tubulin beta 3 class III	Homo sapiens	9-14
25951319-11	2016	TERT analysis on CNB allows the assessment of the pathological population on paraffin sections before DNA isolation, minimizing the risk of false negatives due to poor sampling that affects FNA, and gathering aggregate information about morphology and TERT mutational status.	Paraffin	77-85	telomerase reverse transcriptase	Homo sapiens	0-4
35574028-4	2022	We observed and quantified the expression of apelin, SDHB, CHGB, ERBB-2, CNTN4, and SUCLG2 in paraffin-embedded samples using immunohistochemical staining.	Paraffin	94-102	succinate-CoA ligase GDP-forming subunit beta	Homo sapiens	84-90
35456495-3	2022	We investigated expression levels of CTGF and MMP-1 genes in paraffin-embedded tumours and adjacent normal tissue blocks (ADJ) by Real Time-PCR.	Paraffin	61-69	cellular communication network factor 2	Homo sapiens	37-41
26980650-2	2016	METHODS: Immunohistochemical SP methods were performed to detect the expression of Kv3.4 at tissue level on 57 paraffin-embedded samples collected from Pathology Department of Anhui Province Stomatological Hospital during January 2013 to June 2014.	Paraffin	111-119	potassium voltage-gated channel subfamily C member 4	Homo sapiens	83-88
26980650-10	2016	In 57 paraffin-embedded samples, the positive expression rates of Kv3.4 in normal, precancerous and OSCC tissues were 2/6, 13/18 and 95% (37/39), respectively.	Paraffin	6-14	potassium voltage-gated channel subfamily C member 4	Homo sapiens	66-71
26958083-4	2016	The expression of PD-L1 was evaluated using an anti-PD-L1 immunohistochemistry (IHC) antibody optimized for staining of formalin-fixed paraffin-embedded (FFPE) tissue samples.	Paraffin	135-143	CD274 molecule	Homo sapiens	18-23
35456960-3	2022	The expression of eEF1A1 protein was determined in formalin-fixed, paraffin-embedded prostate cancer and hyperplasia tissue by IHC.	Paraffin	67-75	eukaryotic translation elongation factor 1 alpha 1	Homo sapiens	18-24
35208514-3	2022	Materials and Methods: The gene expression profiles of CD74 and HLA-DRA were determined in formalin-fixed paraffin-embedded tissues, with three samples each from normal cervixes, human papillomavirus type 16/18-positive, low-grade CIN (LGCIN), high-grade CIN (HGCIN), and squamous cell carcinoma (SCC) using Human Transcriptome Array 2.0.	Paraffin	106-114	CD74 molecule	Homo sapiens	55-59
26515144-5	2016	On the paraffin sections S100A6 and atrial natriuretic factor peptides were localized in the heart using immunohistochemistry.	Paraffin	7-15	S100 calcium binding protein A6	Rattus norvegicus	25-31
26893741-6	2016	The expression of calpain-1 and glypican-3 was detected in paraffin-embedded tissues by immunohistochemistry.	Paraffin	59-67	calpain 1	Homo sapiens	18-27
26893741-6	2016	The expression of calpain-1 and glypican-3 was detected in paraffin-embedded tissues by immunohistochemistry.	Paraffin	59-67	glypican 3	Homo sapiens	32-42
2789096-1	1989	Histopathologic and immunohistochemical studies were done on paraffin sections from a patient with alimentary tract lymphoma resembling multiple lymphomatous polyposis of the gastrointestinal tract (MLP).	Paraffin	61-69	MARCKS like 1	Homo sapiens	199-202
26588055-4	2016	We found that expression of miR-671-5p was decreased significantly in invasive ductal carcinoma (IDC) compared to normal in microdissected formalin-fixed, paraffin-embedded (FFPE) tissues.	Paraffin	155-163	microRNA 671	Homo sapiens	28-35
26761215-4	2016	METHODS: Sixty-one paraffin-embedded Rbs were collected from the Henry C. Witelson Ocular Pathology Registry.	Paraffin	19-27	establishment of sister chromatid cohesion N-acetyltransferase 2	Homo sapiens	37-40
26507719-8	2015	Immunofluorescence double staining confirmed the co-localization of CD147 and MMP-11 in paraffin-embedded tissues of CRC patients.	Paraffin	88-96	basigin (Ok blood group)	Homo sapiens	68-73
26332389-3	2015	MACC1 protein expression and localization were determined in 181 paraffin-embedded archived cervical cancer samples using immunohistochemistry.	Paraffin	65-73	MET transcriptional regulator MACC1	Homo sapiens	0-5
26370590-3	2015	METHODS: IGFBP-3 was detected by immunohistochemistry in paraffin-embedded tissues from 70 ESCC patients treated with radiotherapy alone and further examined by western blotting analysis in 10 pairs of fresh ESCC tissues and adjacent non-malignant esophageal specimens.	Paraffin	57-65	insulin like growth factor binding protein 3	Homo sapiens	9-16
26317305-3	2015	We report an automated PD-L1 immunohistochemistry (IHC) assay, which was developed to detect cell surface PD-L1 in formalin-fixed paraffin-embedded human tumor tissue specimens using Dako"s Autostainer Link 48.	Paraffin	130-138	CD274 molecule	Homo sapiens	23-28
26317305-3	2015	We report an automated PD-L1 immunohistochemistry (IHC) assay, which was developed to detect cell surface PD-L1 in formalin-fixed paraffin-embedded human tumor tissue specimens using Dako"s Autostainer Link 48.	Paraffin	130-138	CD274 molecule	Homo sapiens	106-111
26130305-13	2015	It provides a novel method for detecting mutations of the IDH1 gene in paraffin embedded tissue samples of clinical glioma.	Paraffin	71-79	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	58-62
26085332-3	2015	Endosialin expression in paraffin-embedded archival tissue block (PEAT) melanoma tissues was assessed using immunohistochemistry (IHC) with the anti-endosialin, MAb 9G5, in the vessels of American Joint Commission on Cancer (AJCC) Stage III (n = 18) and Stage IV (n = 48) specimens.	Paraffin	25-33	CD248 molecule	Homo sapiens	0-10
24865546-6	2015	METHODS: The abundance of FABP4 expression was analysed by immunohistochemistry on 35 paraffin-embedded AVM and CM sections.	Paraffin	86-94	fatty acid binding protein 4	Homo sapiens	26-31
26143251-3	2015	Mutation of HDA6 led to ectopic hair cells in the nonhair positions of root epidermis in Arabidopsis, based on an analysis of paraffin sections stained with Toluidine Blue.	Paraffin	126-134	histone deacetylase 6	Arabidopsis thaliana	12-16
26421170-7	2015	PATIENTS AND METHODS: In this cross sectional retrospective study immunohistochemistry analyses of formalin-fixed paraffin-embedded (FFPE) tumor tissues were performed to characterize the expression of nuclear beta-catenin in a series of 165 Iranian patients with colorectal carcinoma.	Paraffin	114-122	catenin beta 1	Homo sapiens	210-222
26261669-6	2015	Paraffin-embedded tissue section-FISH analysis demonstrated that the FL was negative for MYC, but MYC protein expression was subsequently detected in the lymph node specimen obtained at the initial diagnosis using IHC.	Paraffin	0-8	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	98-101
25778867-5	2015	Immunohistochemistry (IHC) was conducted to characterize the expression pattern of SPHK1 in 142 archived paraffin-embedded NPC specimens.	Paraffin	105-113	sphingosine kinase 1	Homo sapiens	83-88
25865688-6	2015	GPC-3 protein expression was detected in paraffin-embedded specimens using immunohistochemistry.	Paraffin	41-49	glypican 3	Homo sapiens	0-5
25194563-5	2015	ERCC1 immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissues.	Paraffin	60-68	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	0-5
25589666-2	2015	METHODS: We used the paraffin-embedded tissue (PET) blot, which degrades physiologic nonaggregated aSyn using proteinase K and enhances antigen retrieval allowing sensitive and selective detection of remaining protein aggregates, to detect aSyn in colonic mucosal biopsies from 15 patients with early PD (,3 years), 7 patients with later PD (.5 years), and 11 individuals without PD.	Paraffin	21-29	synuclein alpha	Homo sapiens	99-103
25589666-2	2015	METHODS: We used the paraffin-embedded tissue (PET) blot, which degrades physiologic nonaggregated aSyn using proteinase K and enhances antigen retrieval allowing sensitive and selective detection of remaining protein aggregates, to detect aSyn in colonic mucosal biopsies from 15 patients with early PD (,3 years), 7 patients with later PD (.5 years), and 11 individuals without PD.	Paraffin	21-29	synuclein alpha	Homo sapiens	240-244
25661374-6	2015	miR-145 in 18 paraffin-embedded samples underwent chemotherapy and were assessed by in situ hybridization (ISH).	Paraffin	14-22	microRNA 145	Homo sapiens	0-7
25369740-4	2015	The mRNA expression of LTbetaR in 81 BCa, 10 chronic cystitis and 23 healthy bladder mucosa tissues was investigated by reverse transcription-fluorescent quantitative polymerase chain reaction (RT-FQ-PCR), and protein expression was studied in 73 BCa, 30 cystitis and 15 healthy paraffin-embedded tissue sections by immunohistochemistry.	Paraffin	279-287	lymphotoxin beta receptor	Homo sapiens	23-30
25735325-5	2015	GPC3 immunohistochemistry was applied in the pathological diagnosis of hepatoblastoma using the monoclonal antibodies with formalin-fixed and paraffin-embedded specimens.	Paraffin	142-150	glypican 3	Homo sapiens	0-4
25743805-3	2015	In addition, protein level of Tbx3 were identified using immunochemistry in 80 pairs of paraffin-embedded specimen.	Paraffin	88-96	T-box transcription factor 3	Homo sapiens	30-34
26491674-4	2015	Immunohistochemistry was used to assess OPN expression in OSCC patients" biopsy specimens from paraffin blocks before treatment.	Paraffin	95-103	secreted phosphoprotein 1	Homo sapiens	40-43
26389729-3	2015	METHODS: miR-148a expression was measured by qRT-PCR in patients with colorectal adenoma (n = 21) and CRC (stage I-IV, n = 159) using formalin-fixed paraffin-embedded tissue samples.	Paraffin	149-157	microRNA 148a	Homo sapiens	9-17
25143307-8	2014	In addition, we found loss of SMARCE1 protein in three of 10 paraffin-embedded cranial clear cell meningiomas.	Paraffin	61-69	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1	Homo sapiens	30-37
25432794-6	2014	For detection of the NAB2-STAT6 fusion gene, RT-PCR was performed using RNA extracted from formalin-fixed and paraffin-embedded tissues.	Paraffin	110-118	signal transducer and activator of transcription 6	Homo sapiens	26-31
25025448-5	2014	This study uses a newly described antibody to define the profile of CD103 immunoreactivity in paraffin sections of a wide variety of T-cell neoplasms (184 cases).	Paraffin	94-102	integrin subunit alpha E	Homo sapiens	68-73
25035100-5	2014	TERT promoter mutation analysis on DNA from formalin-fixed, paraffin-embedded specimens was performed by SNaPshot analysis.	Paraffin	60-68	telomerase reverse transcriptase	Mus musculus	0-4
25538369-3	2014	MATERIALS AND METHODS: This study was carried out on 123 paraffin embedded blocks with exact diagnosis of squamous cell carcinoma (SCC).	Paraffin	57-65	serpin family B member 3	Homo sapiens	131-134
25653835-0	2014	Application of ARID1A to murine formalin-fixed paraffin embedded tissue using immunohistochemistry.	Paraffin	47-55	AT rich interactive domain 1A (SWI-like)	Mus musculus	15-21
25653835-1	2014	ARID1A is a known suppressor of tumour formation and the Human Protein Atlas antibody HPA005456 has been demonstrated in previous literature to stain tumour tissue by immunohistochemistry (IHC) in formalin-fixed paraffin embedded human tissue and human cell lines.	Paraffin	212-220	AT-rich interaction domain 1A	Homo sapiens	0-6
25159205-4	2014	METHODS: TERT promoter mutation analysis on fresh tumor DNA and DNA from formalin-fixed, paraffin-embedded specimens was performed by SNaPshot analysis in 102 uveal melanomas, 39 conjunctival melanomas, 26 PAM with atypia, 14 PAM without atypia, and 56 conjunctival nevi.	Paraffin	89-97	telomerase reverse transcriptase	Homo sapiens	9-13
24842555-2	2014	Neuroligin-2 was assessed by Immunohistochemistry staining method on routine paraffin section from different colon tissue segments of HSCR (ganglionic colonic segment, transitional colonic segment and aganglionic colonic segment).	Paraffin	77-85	neuroligin 2	Homo sapiens	0-12
24977739-4	2014	We used a rabbit monoclonal STAT6 antibody (1:100), which has not been reported by others, on formalin fixed, paraffin embedded whole sections and tissue microarray slides.	Paraffin	110-118	signal transducer and activator of transcription 6	Homo sapiens	28-33
25251954-3	2014	MATERIALS AND METHODS: immunohistochemical expression of tissue factor was evaluated in 58 paraffin-embedded samples of clear cell carcinomas of the kidney treated at the same university hospital, that was correlated with clinical and pathological variables and with overall survival.	Paraffin	91-99	coagulation factor III, tissue factor	Homo sapiens	57-70
24763002-1	2014	This study was aimed to investigate the expression of microRNA-21 and its correlation with PTEN in diffuse large B cell lymphoma (DLBCL) paraffin-embedded tissues, and evaluate its potential relevance with clinical characteristics.	Paraffin	137-145	microRNA 21	Homo sapiens	54-65
24763002-1	2014	This study was aimed to investigate the expression of microRNA-21 and its correlation with PTEN in diffuse large B cell lymphoma (DLBCL) paraffin-embedded tissues, and evaluate its potential relevance with clinical characteristics.	Paraffin	137-145	phosphatase and tensin homolog	Homo sapiens	91-95
23978873-7	2014	METHODS: In the present study, the expression patterns of OPN in 80 paraffin-embedded tissue specimens, including 25 VSCC samples, 21 VIN lesions and 21 VLS, in addition to 13 normal vulvar samples, were examined by the immunohistochemical method and chromogenic in situ hybridization.	Paraffin	68-76	secreted phosphoprotein 1	Homo sapiens	58-61
24248894-6	2014	Emerging studies show that miR-21 could be measured stably and easily in tumor tissues, formalin-fixed paraffin-embedded tissues and blood circulation.	Paraffin	103-111	microRNA 21	Homo sapiens	27-33
24172202-3	2014	OBJECTIVE: To explore the clinicopathological significance of the miR-146a level in HCC formalin-fixed paraffin-embedded (FFPE) tissue.	Paraffin	103-111	microRNA 146a	Homo sapiens	66-74
24374892-3	2014	METHODS: The protein levels of hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha were detected by immunohistochemistry on paraffin sections of 126 paired hepatocellular carcinoma tissue and peritumoral tissue samples.	Paraffin	140-148	endothelial PAS domain protein 1	Homo sapiens	67-98
24033439-4	2014	METHODS: Immunohistochemistry for modified tau [phosphorylated at Ser(199-202) -Thr(205) (AT8) and Ser(396-404) (PHF-1) or truncated at D(421) (TauC3) and E(391) (MN423)] was performed on paraffin-embedded human brain sections.	Paraffin	188-196	microtubule associated protein tau	Homo sapiens	43-46
24145648-4	2014	Here, we characterize the new monoclonal anti-SOX11 antibodies, suitable for Western blot assay and immunohistochemistry (IHC) on formalin-fixed paraffin-embedded tissue; we tested them on a large series of primary lymphoid tumors and compared these results with those of other routinely used antibodies.	Paraffin	145-153	SRY-box transcription factor 11	Homo sapiens	46-51
24935362-2	2014	MATERIALS AND METHODS: We have designed four gene molecular beacon (MB) probes for multiplex quantitative real-time polymerase chain reactions to examine RRM1, XRCC1, TUBB3 and TS mRNA expression in paraffin-embedded specimens from 50 patients with advanced or metastatic carcinomas.	Paraffin	199-207	thymidylate synthetase	Homo sapiens	177-179
24761869-2	2014	METHODS: Immunohistochemistry was applied to detect the expression of ERCC1, MSH2 and PARP1 in 111 cases of non-small cell lung cancer paraffin embedded surgical specimens.	Paraffin	135-143	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	70-75
24895573-1	2014	Previously, we found that the expression of microRNA-146a (miR-146a) was downregulated in hepatocellular carcinoma (HCC) formalin-fixed paraffin-embedded (FFPE) tissues compared to the adjacent noncancerous hepatic tissues.	Paraffin	136-144	microRNA 146a	Homo sapiens	44-57
24895573-1	2014	Previously, we found that the expression of microRNA-146a (miR-146a) was downregulated in hepatocellular carcinoma (HCC) formalin-fixed paraffin-embedded (FFPE) tissues compared to the adjacent noncancerous hepatic tissues.	Paraffin	136-144	microRNA 146a	Homo sapiens	59-67
24908312-2	2014	The described protocol has been optimized for IL-1 detection in formalin-fixed paraffin-embedded oral tissue sections by light microscopy.	Paraffin	79-87	interleukin 1 alpha	Homo sapiens	46-50
23873112-2	2013	The expression of HSP90 was investigated in 38 paraffin-embedded samples of PHEO patients using immunohistochemistry.	Paraffin	47-55	heat shock protein 90 alpha family class A member 1	Homo sapiens	18-23
24124529-5	2013	METHODS: Paraffin-embedded specimens from 143 eligible patients were used to investigate the expression of CD274 by immunohistochemistry.	Paraffin	9-17	CD274 molecule	Homo sapiens	107-112
24039846-3	2013	DESIGN: MiR-21 expression was evaluated in formalin-fixed paraffin-embedded samples from patients with esophageal squamous-cell carcinoma (SCC) by quantitative RT-PCR.	Paraffin	58-66	microRNA 21	Homo sapiens	8-14
24023558-3	2013	Moreover, immunohistochemical expression of Prx1 was evaluated in paraffin-embedded tissues from 24 non-small cell lung cancer patients who had received docetaxel-cisplatin regimens as a first-line treatment.	Paraffin	66-74	peroxiredoxin 1	Homo sapiens	44-48
23840303-5	2013	Immunohistochemistry (IHC) was performed to examine FLOT1 protein expression in paraffin-embedded tissues from 196 HCC patients.	Paraffin	80-88	flotillin 1	Homo sapiens	52-57
23518908-3	2013	Expression analysis of AC in n=112 ovarian cancer patients was performed by immunohistochemical analysis of primary paraffin-embedded tumor samples.	Paraffin	116-124	N-acylsphingosine amidohydrolase 1	Homo sapiens	23-25
23281836-3	2013	As determined using in situ hybridization (ISH), 91 of 160 (56.87%) paraffin-embedded NPC biopsies showed high expression levels of HOTAIR (staining index score &gt;= 6).	Paraffin	68-76	HOX transcript antisense RNA	Homo sapiens	132-138
23281836-5	2013	Quantified using real-time PCR, HOTAIR expression levels in fresh tissue and paraffin-embedded samples were 5.2 ~ 48.4-fold higher compared with non-cancer tissue samples.	Paraffin	77-85	HOX transcript antisense RNA	Homo sapiens	32-38
23281836-6	2013	Moreover, HOTAIR expression levels increased with clinical stage progression, which was consistent with ISH findings in the paraffin-embedded tissue.	Paraffin	124-132	HOX transcript antisense RNA	Homo sapiens	10-16
23426585-10	2013	The ski waxers" exposure to paraffin fumes and PFAS is not in compliance with the occupational exposure standards and by far exceed the general populations" exposure.	Paraffin	28-36	SKI proto-oncogene	Homo sapiens	4-7
23355207-3	2013	This study is the first to describe the successful use of a CD103 antibody to identify HCL and HCL-variant in paraffin sections of formalin- or Bouin solution- fixed specimens (n = 68) using an immunoperoxidase technique.	Paraffin	110-118	integrin subunit alpha E	Homo sapiens	60-65
23328703-0	2013	Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.	Paraffin	49-57	CD274 molecule	Homo sapiens	32-37
23328703-0	2013	Immunohistochemical staining of B7-H1 (PD-L1) on paraffin-embedded slides of pancreatic adenocarcinoma tissue.	Paraffin	49-57	CD274 molecule	Homo sapiens	39-44
23328703-9	2013	The anti-B7-H1 monoclonal antibody (clone 5H1) developed by Chen and coworkers has been shown to produce reliable staining results in cryosections of multiple types of human neoplastic tissues, but staining on paraffin-embedded slides had been a challenge until recently.	Paraffin	210-218	CD274 molecule	Homo sapiens	9-14
23328703-10	2013	We have developed the B7-H1 staining protocol for paraffin-embedded slides of pancreatic adenocarcinoma tissues.	Paraffin	50-58	CD274 molecule	Homo sapiens	22-27
23217538-2	2013	STUDY DESIGN: Immunoexpression of p63 protein was studied and quantified in 9 formalin-fixed paraffin-embedded mucous retention cysts, 4 papillary cystadenomas, and 19 low-grade and 9 high-grade mucoepidermoid carcinomas.	Paraffin	93-101	tumor protein p63	Homo sapiens	34-37
23960186-3	2013	METHODS: Single-base extension genotyping of the CTNNB1 gene was performed on 145 sporadic, paraffin-embedded desmoid tumor specimens.	Paraffin	92-100	catenin beta 1	Homo sapiens	49-55
23555954-9	2013	We also found, in clinical formalin fixed paraffin embedded (FFPE) lung cancer samples, that low expression of miR-146a was correlated with advanced clinical TNM stages and distant metastasis in NSCLC (P&lt;0.05).	Paraffin	42-50	microRNA 146a	Homo sapiens	111-119
23216670-7	2012	In paraffin-embedded, formalin-fixed tissues from core needle biopsy tissues from 112 patients, positive phospho-p90RSK expression was associated with greater tumor shrinkage and smaller post-chemotherapy tumor size.	Paraffin	3-11	ribosomal protein S6 kinase A1	Homo sapiens	113-119
22878609-4	2012	METHODS: Immunostaining against ALDH1A1 was performed on a paraffin-embedded tissue microarray including 659 primary colon cancer samples and 338 rectal cancer samples.	Paraffin	59-67	aldehyde dehydrogenase 1 family member A1	Homo sapiens	32-39
23205120-5	2012	Immunohistochemical staining was performed to detect the expression of mTOR and PTEN in paraffin-embedded gastric tissue sections obtained from 33 patients with gastric cancer and 30 normal controls.	Paraffin	88-96	phosphatase and tensin homolog	Homo sapiens	80-84
23064684-2	2012	We examined the expression of ETS-1 using immunohistochemical staining of paraffin-embedded prostate carcinoma tissue obtained by needle biopsy from 69 mostly advanced PCa patients.	Paraffin	74-82	ETS proto-oncogene 1, transcription factor	Homo sapiens	30-35
23291133-2	2012	METHODS: Rab5a and APPL1 in paraffin embedded tissues of 74 breast carcinomas and 40 breast fibromas were detected by immunohistochemistry.	Paraffin	28-36	RAB5A, member RAS oncogene family	Homo sapiens	9-14
23291133-2	2012	METHODS: Rab5a and APPL1 in paraffin embedded tissues of 74 breast carcinomas and 40 breast fibromas were detected by immunohistochemistry.	Paraffin	28-36	adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1	Homo sapiens	19-24
22325460-4	2012	METHODS: Sox10 expression was examined by immunohistochemistry in 145 cases of formalin-fixed paraffin-embedded tissue, including benign and malignant melanocytic lesions of various histologies and stages (n = 83), fibrohistiocytic and histiocytic lesions (n = 33), and peripheral nerve sheath tumors (n = 19), among others (n = 10).	Paraffin	94-102	SRY-box transcription factor 10	Homo sapiens	9-14
22797604-4	2012	Expression of MAD2 was investigated             in paraffin-embedded sections using a MAD2 antibody.	Paraffin	51-59	mitotic arrest deficient 2 like 1	Homo sapiens	14-18
22772381-8	2012	mRNA expression of MARCKSL1 in formalin fixed paraffin-embedded tissue was also prognostic (P = 0.002, HR = 3.6, 95 % CI = 1.5-8.3).	Paraffin	46-54	MARCKS like 1	Homo sapiens	19-27
22204715-4	2012	We describe an approach for analyzing formalin-fixed, paraffin-embedded breast tumors on tissue microarrays with TOP2A fluorescence in situ hybridization coupled with cytokeratin immunofluorescence to target tumor cells.	Paraffin	54-62	DNA topoisomerase II alpha	Homo sapiens	113-118
22445362-2	2012	Immunohistochemistry using a mouse monoclonal antibody has a high specificity and sensitivity for detecting IDH1 R132H mutant protein in sections from formalin-fixed, paraffin-embedded tissue.	Paraffin	167-175	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	108-112
22301701-0	2012	Loss of keratin 13 in oral carcinoma in situ: a comparative study of protein and gene expression levels using paraffin sections.	Paraffin	110-118	keratin 13	Homo sapiens	8-18
22177891-4	2012	Expression of ERCC1 protein detected by immunohistochemistry on paraffin sections was correlated with the histological subtypes.	Paraffin	64-72	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	14-19
22436573-3	2012	METHODS: We investigated the mRNA and protein expression of ERCC1 and RRM1 by RT-PCR and immunohistochemistry (IHC) in formalin-fixed, paraffin-embedded pancreatic ductal carcinoma (PDA) tissues.	Paraffin	135-143	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	60-65
22397399-4	2012	In situ hybridization (ISH) was performed to detect miRNA-126 in formalin-fixed paraffin embedded tissue from primary tumours.	Paraffin	80-88	microRNA 126	Homo sapiens	52-61
23098507-3	2012	METHODS: To investigate the expression of SMO protein in colon cancer and its association with clinicopathological parameters and postoperative liver metastasis, immunohistochemistry was performed with paraffin-embedded specimens of 96 cases.	Paraffin	202-210	smoothened, frizzled class receptor	Homo sapiens	42-45
23304250-4	2012	METHODS: Immunohistochemical staining using antibodies to filaggrin was performed on paraffin sections of normal human conjunctiva, and on conjunctiva with different degrees of mechanical conjunctival stress.	Paraffin	85-93	filaggrin	Homo sapiens	58-67
22336504-3	2011	Genetic Leu125Val polymorphism of PECAM-1 was detected by PCR-SSCP in myocardial paraffin blocks of 37 ACS cases and 43 control cases, and Ser128Arg polymorphism of E-selectin was detected by PCR-RFLP in myocardial paraffin blocks of 39 ACS cases and 43 control cases, respectively.	Paraffin	215-223	selectin E	Homo sapiens	165-175
21725289-4	2011	FGFR2 immunostaining was assessed in three tissue microarrays: one constructed from paraffin-embedded blocks of 60 samples of normal endometrium in different phases of menstrual cycle, and two tissue microarrays containing endometrial carcinoma samples (95 and 62 cases).	Paraffin	84-92	fibroblast growth factor receptor 2	Homo sapiens	0-5
22014664-1	2011	To clarify the status and distribution of Fas and Fas-Ligand (FasL) in yak"s placentomes, immunohistochemistry (IHC) was carried out to analyze the expression and location of Fas and FasL in paraffin embedded sections.	Paraffin	191-199	Fas ligand	Homo sapiens	183-187
22321848-3	2011	And the expressions of uPA and uPAR in paraffin-embedded tissues were detected by immunohistochemistry.	Paraffin	39-47	plasminogen activator, urokinase receptor	Homo sapiens	31-35
20582634-7	2011	The liver paraffin sections were detected with myeloperoxidase.	Paraffin	10-18	myeloperoxidase	Rattus norvegicus	47-62
21440997-7	2011	Immunohistochemistry performed for PSA on paraffin section was negative.	Paraffin	42-50	kallikrein related peptidase 3	Homo sapiens	35-38
21310472-2	2011	METHODS: An immunohistochemistry assay was used to detect p27 in formalin-fixed paraffin-embedded ovarian tumors from 3 distinct sources.	Paraffin	80-88	interferon alpha inducible protein 27	Homo sapiens	58-61
21768699-3	2011	OPN protein expression in 67 paraffin-embedded NPC tissue and 21 NNET samples was detected by immunohistochemistry (IHC).	Paraffin	29-37	secreted phosphoprotein 1	Homo sapiens	0-3
21273026-3	2011	HMGA2 protein expression was assessed by immunohistochemical analysis of 148 paraffin-embedded specimens of human BUC and 30 specimens of adjacent normal bladder tissue.	Paraffin	77-85	high mobility group AT-hook 2	Homo sapiens	0-5
21111449-5	2011	Growth arrest-specific gene 1 protein was immunostained in 118 paraffin-embedded specimens.	Paraffin	63-71	growth arrest specific 1	Homo sapiens	0-29
19836228-2	2011	METHODS: VEGF and EMMPRIN expression in paraffin-embedded specimens gathered from 65 patients with primary osteosarcoma were detected by the method of immunohistochemistry using antibodies against VEGF and EMMPRIN.	Paraffin	40-48	basigin (Ok blood group)	Homo sapiens	18-25
20851148-7	2011	CONCLUSIONS: The rabbit monoclonal antibody UMB-3 is an excellent tool for immunoprecipitation of MOR from native sources as well as for immunohistochemical staining of MOR in paraffin-embedded tissue samples of rodent and human origin.	Paraffin	176-184	opioid receptor mu 1	Homo sapiens	169-172
21107850-8	2011	The preponderance of SHH activity in adult MB tumours was also shown by positive SFRP1 immunostaining in 16/19 adult paraffin-embedded adult MB tumour blocks.	Paraffin	117-125	sonic hedgehog signaling molecule	Homo sapiens	21-24
21563555-4	2011	METHODS: In a retrospective study conducted from January 2000 to June 2006, we used immunohistochemistry to analyse the protein expression of p63, p53, and Ki-67 in paraffin-embedded tumour samples from 22 BSCC patients and compared the clinicopathological parameters with the survival outcome.	Paraffin	165-173	tumor protein p63	Homo sapiens	142-145
20652290-4	2011	MMP-1 expression was tested in samples from paraffin-embedded tumor by immunohistochemical staining.	Paraffin	44-52	matrix metallopeptidase 1	Homo sapiens	0-5
21266251-5	2011	In this chapter, we briefly review the roles of ATF3 in cellular adaptive-response and UPR, and then describe the detailed steps and tips that we developed based on general immunohistochemistry (IHC) protocols to detect ATF3 on paraffin embedded sections.	Paraffin	228-236	activating transcription factor 3	Homo sapiens	220-224
20724141-5	2010	HMGA1 expression was determined by immunohistochemistry on original paraffin embedded tissue from 99 pancreatic head- and 112 periampullary cancers (with R0).	Paraffin	68-76	high mobility group AT-hook 1	Homo sapiens	0-5
21165442-2	2010	Polyclonal antibodies to Iba1 antigen obtained after immunization with a synthetic peptide corresponding to 81-93 amino acid fragment of Iba1 antigen selectively interact with microglia cells on paraffin sections of rat brain.	Paraffin	195-203	allograft inflammatory factor 1	Rattus norvegicus	25-29
21165442-2	2010	Polyclonal antibodies to Iba1 antigen obtained after immunization with a synthetic peptide corresponding to 81-93 amino acid fragment of Iba1 antigen selectively interact with microglia cells on paraffin sections of rat brain.	Paraffin	195-203	allograft inflammatory factor 1	Rattus norvegicus	137-141
20847279-3	2010	We have developed a pyrosequencing assay that allows both the sensitive and rapid detection of mutant IDH1 alleles in DNA extracted from formalin-fixed, paraffin-embedded tissues.	Paraffin	153-161	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	102-106
20558462-2	2010	METHODS: Immunohistochemical staining was performed to detect the expression of CD147 and vascular endothelial growth factor in paraffin-embedded sections from 62 bone marrow biopsies obtained from an equal number of patients with newly diagnosed acute myeloid leukemia.	Paraffin	128-136	basigin (Ok blood group)	Homo sapiens	80-85
20545466-3	2010	MATERIAL AND METHODS: EF-1alpha was evaluated by immunostaining in paraffin-embedded specimens of prostates obtained from 80 patients with PCa.	Paraffin	67-75	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	22-31
2685109-1	1989	Cells containing immunoreactive vimentin-type intermediate filaments (IF) were identified in paraffin sections and whole-mount preparations of the gerbil inner ear.	Paraffin	93-101	vimentin	Homo sapiens	32-40
2673751-2	1989	We have clearly demonstrated corticotropin-releasing hormone (CRH) immunoreactive cell bodies and nerve fibers in the human hypothalamus by immunocytochemistry using free-floating sections instead of paraffin-embedded sections.	Paraffin	200-208	corticotropin releasing hormone	Homo sapiens	62-65
3055807-1	1988	Expression of beta 2-microglobulin, a reliable marker of HLA Class I, on the interlobular bile ducts (bile ducts) was surveyed using an immunoperoxidase method in paraffin sections of specimens from patients with a variety of hepatobiliary diseases.	Paraffin	163-171	beta-2-microglobulin	Homo sapiens	14-34
3045276-0	1988	Optimal preservation of p21 ras immunoreactivity and morphology in paraffin-embedded tissue.	Paraffin	67-75	H3 histone pseudogene 16	Homo sapiens	24-27
3045276-1	1988	Specific immunostaining of p21 ras protein by the well-characterized pan-ras antibody Y13-259 is achieved in paraffin sections of human and animal tissues fixed in periodate-lysine-paraformaldehyde-dichromate (PLPD).	Paraffin	109-117	HRas proto-oncogene, GTPase	Homo sapiens	27-34
2453500-1	1988	The presence of alpha 2-macroglobulin (alpha 2M) was detected with the avidin-biotin technique in more than 20-yr-old paraffin blocks from human sarcomas.	Paraffin	118-126	alpha-2-macroglobulin	Homo sapiens	16-37
2453500-1	1988	The presence of alpha 2-macroglobulin (alpha 2M) was detected with the avidin-biotin technique in more than 20-yr-old paraffin blocks from human sarcomas.	Paraffin	118-126	alpha-2-macroglobulin	Homo sapiens	39-47
3318757-2	1987	To gain a better understanding of the role these oncogenes may play in malignant transformation, we evaluated the levels of a ras gene protein product (p21) in formaldehyde-fixed, paraffin-embedded specimens of normal human colonic mucosa, hyperplastic polyps, tubular adenomas, villous adenomas, and epithelium from a patient with ulcerative colitis.	Paraffin	180-188	H3 histone pseudogene 16	Homo sapiens	152-155
2959166-11	1987	We conclude that LN-1, preferably in combination with LN-2, can be used for distinguishing between SNC and LBL in paraffin-embedded, B5-fixed tissue when fresh tissue is not available.	Paraffin	114-122	phytanoyl-CoA 2-hydroxylase	Homo sapiens	17-21
2888448-2	1987	In this study, PCNA was identified by paraffin-section immunohistochemistry in 42 of 64 solid human malignancies, and in several benign tissues known to contain proliferating cells.	Paraffin	38-46	proliferating cell nuclear antigen	Homo sapiens	15-19
2422219-11	1986	UCHL1 is a monoclonal antibody that identifies T cells in formalin fixed paraffin embedded tissues, and should prove useful for diagnosing T cell lymphomas, especially when only formalin fixed tissue is available for diagnosis.	Paraffin	73-81	ubiquitin C-terminal hydrolase L1	Homo sapiens	0-5
2430706-1	1986	NKI/C-3 and NKI/black-13 are monoclonal antibodies recognizing different epitopes on a melanoma-associated antigen that is preserved after fixation in formalin and embedding in paraffin in virtually all melanoma tissues.	Paraffin	177-185	ankyrin repeat domain 36B	Homo sapiens	87-114
3512687-1	1986	The distribution of beta 2-microglobulin (beta 2-m) was studied by immunoperoxidase in paraffin sections of 30 liver biopsies from 28 patients with primary biliary cirrhosis (PBC).	Paraffin	87-95	beta-2-microglobulin	Homo sapiens	20-40
3902214-0	1985	HLA class I and beta 2-microglobulin expression in frozen and formaldehyde-fixed paraffin sections of neuroblastoma tumors.	Paraffin	81-89	beta-2-microglobulin	Homo sapiens	16-36
3000024-1	1985	Specific antibodies to fibronectin and type I collagen in rat livers were used to demonstrate these matrix proteins with direct immunoperoxidase method in paraffin sections of normal liver, DAB-induced hepatoma and CCl4-induced fibrotic liver.	Paraffin	155-163	fibronectin 1	Rattus norvegicus	23-34
4030399-1	1985	Ornithine decarboxylase was localized immunohistochemically in paraffin sections of prostate glands of the rat using Sternberger"s PAP technique.	Paraffin	63-71	ornithine decarboxylase 1	Rattus norvegicus	0-23
2578532-3	1985	At present beta 2M is best identified in paraffin-embedded tissue by means of a triple-layer peroxidase-antiperoxidase technique, using mammalian polyclonal antisera.	Paraffin	41-49	beta-2-microglobulin	Homo sapiens	11-18
2578532-10	1985	It is the most suitable technique for the investigation of the distribution of beta 2M in paraffin-embedded tissue.	Paraffin	90-98	beta-2-microglobulin	Homo sapiens	79-86
6337191-1	1983	Antisera to the intermediate filaments vimentin and desmin react with fixed paraffin embedded tissue.	Paraffin	76-84	vimentin	Homo sapiens	39-47
6337191-1	1983	Antisera to the intermediate filaments vimentin and desmin react with fixed paraffin embedded tissue.	Paraffin	76-84	desmin	Homo sapiens	52-58
6344097-0	1983	Papovavirus antigens in paraffin sections of PML brains.	Paraffin	24-32	PML nuclear body scaffold	Homo sapiens	45-48
7041611-1	1982	The use of an immunohistochemical technic offers a very sensitive method to detect myoglobin in formalin-fixed, paraffin-embedded tissues.	Paraffin	112-120	myoglobin	Homo sapiens	83-92
479557-2	1979	The intracellular distribution of ligandin and Z protein was studied by applying the peroxidase-antiperoxidase procedure of L. A. Sternberger (Immunocytochemistry, Prentice Hall Inc., 1974) to paraffin sections and free-floating 10-micrometers frozen sections that were processed for both light and electron microscopy.	Paraffin	193-201	transmembrane BAX inhibitor motif containing 4	Homo sapiens	47-56
211158-1	1978	Paraffin sections of mouse adrenals processed with antiserum to luteinizing hormone-releasing hormone (LHRH) in the unlabeled antibody enzyme method reveal moderate staining in the cytoplasm of cells of zona fasciculata and reticularis.	Paraffin	0-8	gonadotropin releasing hormone 1	Mus musculus	64-101
211158-1	1978	Paraffin sections of mouse adrenals processed with antiserum to luteinizing hormone-releasing hormone (LHRH) in the unlabeled antibody enzyme method reveal moderate staining in the cytoplasm of cells of zona fasciculata and reticularis.	Paraffin	0-8	gonadotropin releasing hormone 1	Mus musculus	103-107
62099-1	1976	The purpose of this study was to explore a method by which an improved immunofluorescent staining can be applied to formalin-fixed paraffin sections to demonstrate cellular or tissue deposits of immunoglobulins, complement and fibrin, and to demonstrate alpha-1-antitrypsin storage and hepatitis B antigens in liver, toxoplasma in heart, and carcinoembryonic antigens in colonic cancer.	Paraffin	131-139	adrenoceptor alpha 1D	Homo sapiens	254-261
1095822-1	1975	An immunohistochemical staining to demonstrate the hepatitis B core and surface antigens (HBc&amp;sAg) on formalin-fixed, paraffin-embedded liver tissue was investigated.	Paraffin	122-130	S-antigen visual arrestin	Homo sapiens	98-101
1095822-5	1975	The immunoreactive sites of HBc&amp;s Ag are shown to be preserved in the formalin-fixed, paraffin-embedded tissue, and they can be demonstrated by either direct or indirect immunofluorescent and immunoperoxidase methods.	Paraffin	90-98	keratin 88, pseudogene	Homo sapiens	28-31
1095822-9	1975	The described method demonstrating the HBc Ag in paraffin tissue may offer an additional means in making a specific etiologic diagnosis of hepatitis B viral disease.	Paraffin	49-57	keratin 88, pseudogene	Homo sapiens	39-42
13027337-0	1952	Application of histochemical technic for cholinesterase to paraffin sections.	Paraffin	59-67	butyrylcholinesterase	Homo sapiens	41-55
33635430-4	2021	METHODS: In this retrospective study, Sanger sequencing was performed to detect TERT-p mutations in formalin-fixed paraffin-embedded tissue samples from 37 patients with penile SCC, 16 patients with cutaneous SCC, and 4 patients with non-neoplastic penile/skin tissue.	Paraffin	115-123	telomerase reverse transcriptase	Homo sapiens	80-84
33226123-3	2021	We explored the incidence of isocitrate dehydrogenase 1 gene variants by hotspot sequencing in 80 formalin-fixed paraffin-embedded tissues of different types of glioma biopsy samples.	Paraffin	113-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	29-55
33155793-13	2021	Therewithal, these findings also highlight the importance of taking into consideration of histological patterns, when choosing a paraffin block for the PDL1.	Paraffin	129-137	CD274 molecule	Homo sapiens	152-156
33560842-5	2021	The underlying principle is that when the NIR was applied, UGB would be actuated to slide along the NIR trace because the irradiated domain melts for a slippery surface within 1.0 s. Once the NIR is removed, the liquefied paraffin would be reconfigured to solid phase for pinning a moving UGB within 0.5 s. Newly explored hydrokinetics imparts us with capability of steering UGBs to arrange any desirable patterns and switch light-path behaving as the light-control-light optical shutter.	Paraffin	222-230	secretoglobin family 1A member 1	Homo sapiens	59-62
33560842-5	2021	The underlying principle is that when the NIR was applied, UGB would be actuated to slide along the NIR trace because the irradiated domain melts for a slippery surface within 1.0 s. Once the NIR is removed, the liquefied paraffin would be reconfigured to solid phase for pinning a moving UGB within 0.5 s. Newly explored hydrokinetics imparts us with capability of steering UGBs to arrange any desirable patterns and switch light-path behaving as the light-control-light optical shutter.	Paraffin	222-230	secretoglobin family 1A member 1	Homo sapiens	289-292
33623414-5	2021	Microarray paraffin blocks from 70 samples of ADC (N=33), SqCC (N=24), and LCC (N=13) were used to create PD-L1 multiplex immunofluorescence assays with a Cell Signaling E1L3N clone.	Paraffin	11-19	CD274 molecule	Homo sapiens	106-111
33297605-3	2020	METHODS: The expressions of EGR1 in GBM were detected with qRT-PCR and immunohistochemistry in 12 pairs of fresh GBM tissues and 116 paraffin-embedded specimens.	Paraffin	133-141	early growth response 1	Homo sapiens	28-32
33291081-2	2020	We performed microarray and bioinformatics analyses to identify genes that were induced upon CCDC170 overexpression, and confirmed our findings by evaluating paraffin-embedded breast cancer tissues and conducting cellular assays.	Paraffin	158-166	coiled-coil domain containing 170	Homo sapiens	93-100
33299472-2	2020	PD-L1 testing has been validated and is currently certified only on formalin-fixed paraffin-embedded materials but not on cytological smears.	Paraffin	83-91	CD274 molecule	Homo sapiens	0-5
33299472-10	2020	With the same cut-off, and assuming as gold-standard the results on formalin-fixed paraffin-embedded materials, PD-L1 evaluation on smears showed specificity and negative predictive values of 98.1% and 93.9%, respectively.	Paraffin	83-91	CD274 molecule	Homo sapiens	112-117
33292612-6	2020	LDLR expression was evaluated by immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue.	Paraffin	72-80	low density lipoprotein receptor	Homo sapiens	0-4
33161980-5	2020	SECURA-3 was also unveiled as a potential probe that could replace its counterpart antibody in the histostaining-based detection of PTTG1 in HeLa and MCF-7 formalin-fixed paraffin-embedded cell blocks.	Paraffin	171-179	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	132-137
33134597-2	2020	Methods: Immunohistochemistry was performed to evaluate the expression of MMR proteins (MLH1, MSH2, MSH6, and PMS2) in formalin-fixed paraffin-embedded sections prepared from surgically resected primary SBCs from 30 patients during March 2002 to March 2017.	Paraffin	134-142	mutL homolog 1	Homo sapiens	88-92
32886667-5	2020	Immunohistochemistry for IDH1-R132H was done on 5-microns-thick formalin-fixed, paraffin-embedded tumor sections with the use of antibody specific for the mutant IDH1-R132H protein.	Paraffin	80-88	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	25-29
32534365-3	2020	METHOD AND RESULTS: We examined 86 thyroid lymphoma cases using fluorescence in situ hybridization (FISH) for the detection of t(3;14)/FOXP1-IGH in formalin fixed paraffin-embedded tissue (FFPE).	Paraffin	163-171	forkhead box P1	Homo sapiens	135-140
33659347-6	2020	Herein, using tyramide signal amplification (TSA), we present two protocols for the IF detection of MYCN and MYC on formalin-fixed paraffin embedded (FFPE) tumor sections and in cell lines fixed in situ after growth as adherent cultures on chambered microscope slides.	Paraffin	131-139	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	100-104
33659347-6	2020	Herein, using tyramide signal amplification (TSA), we present two protocols for the IF detection of MYCN and MYC on formalin-fixed paraffin embedded (FFPE) tumor sections and in cell lines fixed in situ after growth as adherent cultures on chambered microscope slides.	Paraffin	131-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	100-103
32079442-5	2020	PD-L1 expression was evaluated by immunohistochemistry on formalin fixed, paraffin embedded tissue sections.	Paraffin	74-82	CD274 molecule	Homo sapiens	0-5
32536910-4	2020	Immunohistochemical expression and cellular localization of IDO2 was evaluated on 191 formalin-fixed and paraffin-embedded resected NSCLC.	Paraffin	105-113	indoleamine 2,3-dioxygenase 2	Homo sapiens	60-64
32370743-2	2020	METHODS: We investigated the expression and localization of miR-18a and -18b in formalin fixed paraffin embedded (FFPE) tissue from lymph node negative breast cancers (n = 40), by chromogenic in situ hybridization (CISH).	Paraffin	95-103	microRNA 18a	Homo sapiens	60-76
32432058-4	2020	Methods: TM immunoexpression was assessed in n=185 formalin-fixed paraffin-embedded (FFPE) bladder tissue cores from n=98 patients by IHC.	Paraffin	66-74	thrombomodulin	Homo sapiens	9-11
31205070-3	2020	We investigated 6 antibodies that are commonly used for breast cancer subtyping in research studies with immunohistochemistry (ER, PR, HER2, CK5/6, EGFR, and Ki67) in formalin-fixed paraffin-embedded breast tissue microarrays consisting of 148 patients.	Paraffin	182-190	keratin 5	Homo sapiens	141-146
32719261-6	2020	Subjects and Methods: This study was designed to identify immunohistochemically the expression of p53 and MDM2 gene using monoclonal antibody in 60 cases of formalin-fixed paraffin-embedded tissue blocks, of which 20 cases were of solid multicystic ameloblastoma (SMA), 20 cases were of odontogenic keratocyst (OKC), and 20 cases were of unicystic ameloblastoma (UA).	Paraffin	172-180	transformation related protein 53, pseudogene	Mus musculus	98-101
31842702-5	2020	In addition, it indicates that Olig2 is a useful marker to confirm glial lineage in formalin-fixed, paraffin-embedded bovine tissue.	Paraffin	100-108	oligodendrocyte transcription factor 2	Bos taurus	31-36
32106836-3	2020	METHODS: Syntenin expression levels were determined in paraffin-embedded lung cancer tissue specimens (n = 191) using immunohistochemistry.	Paraffin	55-63	syndecan binding protein	Homo sapiens	9-17
32411320-7	2020	The increase of SRXN1 protein expression was confirmed by immunohistochemistry in mouse prostate tumor paraffin samples.	Paraffin	103-111	sulfiredoxin 1 homolog (S. cerevisiae)	Mus musculus	16-21
30095463-2	2020	Our aim was to test a novel in situ hybridization technique, RNAscope, for the detection of human telomerase reverse transcriptase (hTERT) mRNA in archival formalin-fixed, paraffin-embedded (FFPE) tissue and to compare the mRNA expression of melanomas and benign naevi.	Paraffin	172-180	telomerase reverse transcriptase	Homo sapiens	98-130
30095463-2	2020	Our aim was to test a novel in situ hybridization technique, RNAscope, for the detection of human telomerase reverse transcriptase (hTERT) mRNA in archival formalin-fixed, paraffin-embedded (FFPE) tissue and to compare the mRNA expression of melanomas and benign naevi.	Paraffin	172-180	telomerase reverse transcriptase	Homo sapiens	132-137
32524570-7	2020	The purpose of this chapter is to briefly summarize the current understanding of Notch signaling in familial CCM and to provide a protocol for detecting cleaved Notch1 receptor proteins on paraformaldehyde-fixed paraffin-embedded mouse tissue.	Paraffin	212-220	notch 1	Mus musculus	161-167
31741991-10	2019	The beta-catenin expression was examined from the NPC tissue paraffin block with the immunohistochemical cracking technique, using an anti-beta-catenin rabbit polyclonal antibody from Boster Biotechnology, California, USA.	Paraffin	61-69	catenin alpha-1	Oryctolagus cuniculus	4-16
31443698-4	2019	Immunohistochemistry was performed to validate the expression of two upregulated (EpCAM, FADD) and two downregulated (NDRG1, alphaB-crystallin) proteins in 190 paraffin-embedded tissue samples.	Paraffin	160-168	Fas associated via death domain	Homo sapiens	89-93
31161965-2	2019	Therefore, sensitive and specific monoclonal antibodies (mAbs) targeting PDPN are needed for immunohistochemical analyses using formalin-fixed paraffin-embedded tissues.	Paraffin	143-151	podoplanin	Cricetulus griseus	73-77
31186735-5	2019	The expression of PD-L1 in 47 formalin-fixed, paraffin-embedded, NSCLC specimens was assessed using IHC and reverse transcription-quantitative polymerase chain reaction (RT-qPCR).	Paraffin	46-54	CD274 molecule	Homo sapiens	18-23
31118064-4	2019	METHODS: Expression of CYR61 was determined by immunohistochemistry (IHC), quantitative real-time PCR (qRT-PCR) and western blotting (WB) in CRC patients paraffin specimens and colon cell lines.	Paraffin	154-162	cellular communication network factor 1	Homo sapiens	23-28
31060525-6	2019	METHODS: The expression levels of miR-944 were detected using quantitative reverse transcription polymerase chain reaction in five types of cervical cancer cell lines and 116 formalin-fixed paraffin-embedded (FFPE) cervical tissues.	Paraffin	190-198	microRNA 944	Homo sapiens	34-41
31050216-2	2019	In particular, robust IHC assays performed on formalin-fixed, paraffin-embedded (FFPE) tumor tissue are widely used as surrogate markers for ALK and ROS1 rearrangements and for detecting programmed death ligand 1 (PD-L1) expression in patients with advanced NSCLC; in addition, they have become essential for treatment decisions.	Paraffin	62-70	CD274 molecule	Homo sapiens	214-219
30797997-6	2019	The GSP-paraffin composites with 35 wt% GSP loading possess the minimum reflection loss (RL) value of -21.9 dB at 1.6 mm, and effective absorption bandwidth of 4.72 GHz.	Paraffin	8-16	GSM1	Homo sapiens	4-7
30797997-6	2019	The GSP-paraffin composites with 35 wt% GSP loading possess the minimum reflection loss (RL) value of -21.9 dB at 1.6 mm, and effective absorption bandwidth of 4.72 GHz.	Paraffin	8-16	GSM1	Homo sapiens	40-43
30614606-3	2019	The levels of MNX1 in paraffin-embedded CRC specimens were detected by immunohistochemistry (IHC).	Paraffin	22-30	motor neuron and pancreas homeobox 1	Homo sapiens	14-18
30984555-6	2019	Expression profile of ERp29 in 94 osteosarcoma cases was investigated using immunohistochemically stained on formalin-fixed paraffin-embedded biopsied tissue.	Paraffin	124-132	endoplasmic reticulum protein 29	Homo sapiens	22-27
30797712-4	2019	In situ hybridization and qPCR were used to evaluate the expression of MALAT1 and miR-106b-5p in the paraffin-embedded normal and CRC tissues.	Paraffin	101-109	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	71-77
30744560-4	2019	METHODS: SHH was detected by immunohistochemistry (IHC) on paraffin-embedded liver sections in subjects (N = 69) with biopsy proven NAFLD and no liver disease (control).	Paraffin	59-67	sonic hedgehog signaling molecule	Homo sapiens	9-12
29084060-1	2019	Interpretative criteria for programmed death-ligand 1 (PD-L1) immunohistochemistry (IHC) have been largely based on data from formalin-fixed, paraffin-embedded tissues, despite the fact that cytologic specimens, especially cell blocks, are often the only or most readily available tissue for testing.	Paraffin	142-150	CD274 molecule	Homo sapiens	55-60
30539907-4	2018	Methods: PAI-1 expression was detected by tissue microarray-based immunohistochemical staining in formalin-fixed paraffin-embedded specimens from 93 PDAC patients with surgical resection from September 2004 to December 2008.	Paraffin	113-121	serpin family E member 1	Homo sapiens	9-14
20597139-3	2010	Studies using paraffin-embedded tissue have indicated that high mobility group AT-hook 2 (HMGA2) overexpression is present in a high percentage of malignant thyroid neoplasms but not in benign thyroid neoplasms.	Paraffin	14-22	high mobility group AT-hook 2	Homo sapiens	59-88
20597139-3	2010	Studies using paraffin-embedded tissue have indicated that high mobility group AT-hook 2 (HMGA2) overexpression is present in a high percentage of malignant thyroid neoplasms but not in benign thyroid neoplasms.	Paraffin	14-22	high mobility group AT-hook 2	Homo sapiens	90-95
20515682-7	2010	By using both antibodies, we evaluated the tissue expression of SIP1 in paraffin-embedded tissue microarrays consisting of 22 normal and 101 tumoral tissues of kidney, colon, stomach, lung, esophagus, uterus, rectum, breast and liver.	Paraffin	72-80	zinc finger E-box binding homeobox 2	Homo sapiens	64-68
21122384-1	2010	OBJECTIVE: To investigate the significance of detecting TCR gene clonal rearrangement in the diagnosis of mycosis fungoides (MF) and to optimize the primers used for detecting the TCR gene clonal rearrangement with PCR in paraffin embedded tissues of MF.	Paraffin	222-230	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	180-183
20699501-11	2010	CONCLUSION: Activated B and T cells express COX-1 and COX-2 in paraffin-embedded tissue sections of chronic tonsillitis.	Paraffin	63-71	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	44-49
20102291-5	2010	Immunohistochemistry for MMP-1 was performed on formalin fixed and paraffin embedded sections.	Paraffin	67-75	matrix metallopeptidase 1	Homo sapiens	25-30
19286191-3	2010	METHODS: CD147/EMMPRIN expression in 52 patients with renal carcinoma, 58 patients with bladder carcinoma, 101 patients with prostate carcinoma, 17 patients of penis carcinoma, and 17 patients of testis carcinoma were examined by immunostaining on paraffin-embedded tumor specimens using monoclonal antibodies.	Paraffin	248-256	basigin (Ok blood group)	Homo sapiens	9-14
20459648-3	2010	The expressions of IDH1 and p53 in formalin-fixed paraffin-embedded tissue sections from 44 osteosarcoma patients were determined by immunohistochemistry, and the correlation between them and clinicopagthological features were analyzed.	Paraffin	50-58	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	19-23
2674299-5	1989	Using polyclonal antibodies and the avidin-biotin peroxidase complex, we demonstrated the presence of both IL-1 alpha and IL-1 beta in normal and psoriatic formalin-fixed paraffin-embedded tissues.	Paraffin	171-179	interleukin 1 alpha	Homo sapiens	107-117
19398252-2	2010	Paraffin sections of primary SCC of the tongue and normal mucosa were screened immunohistochemically for Notch1 and EGFR proteins.	Paraffin	0-8	serpin family B member 3	Homo sapiens	29-32
30121940-3	2018	We performed immunohistochemistry (IHC) for PD-L1 on formalin-fixed paraffin-embedded tissues.	Paraffin	68-76	CD274 molecule	Homo sapiens	44-49
2685216-2	1989	Lymphocytes infiltrating into the cancer tissue before and after administration of rIL-2 were observed on paraffin embedded sections by Hematoxilin Eosin (HE) stain in relation to the clinical effect.	Paraffin	106-114	interleukin 2	Rattus norvegicus	83-88
28362707-2	2018	Cytochrome c oxidase subunit I (CcOI) can help assess apoptosis resistance in paraffin-embedded biopsies.	Paraffin	78-86	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	0-30
28362707-2	2018	Cytochrome c oxidase subunit I (CcOI) can help assess apoptosis resistance in paraffin-embedded biopsies.	Paraffin	78-86	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	32-36
19963137-0	2010	Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues.	Paraffin	85-93	high mobility group AT-hook 1	Homo sapiens	10-15
19963137-5	2010	Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci.	Paraffin	43-51	high mobility group AT-hook 1	Homo sapiens	92-97
2774054-1	1989	In formalin-fixed, paraffin-embedded synovial tissues from patients with early proliferative rheumatoid arthritis (RA), immunoreactivity could be demonstrated utilizing monoclonal IgG antibodies reactive with the p19 and p24 protein of human T cell leukemia virus (HTLV-I).	Paraffin	19-27	interleukin 23 subunit alpha	Homo sapiens	213-216
19895170-3	2010	We have shown, that application of nested two-stage methylation-specific PCR (MSP) is asuitable method for analysis of epigenetically silenced GSTP1 in formalin-fixed paraffin-embedded (FFPE) tissues from breast cancer patients.	Paraffin	167-175	glutathione S-transferase pi 1	Homo sapiens	143-148
19915484-3	2009	We describe a simple and accurate molecular assay for detection of IDH1/2 mutations on routine formalin-fixed paraffin-embedded tissues.	Paraffin	110-118	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	67-73
30299371-0	2018	Detection of IDH1 and IDH2 Mutation in Formalin-fixed Paraffin-embedded Gliomas Using Allele-specific COLD-PCR and Probe Melting Curve Analysis.	Paraffin	54-62	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	13-17
30072169-3	2018	Recently, antibodies against the STAT6 C-terminal, are being used in paraffin-embedded tissues as a surrogate for identifying the NAB2-STA6 fusion gene which is considered a specific molecular marker for solitary fibrous tumor.	Paraffin	69-77	signal transducer and activator of transcription 6	Homo sapiens	33-40
2671679-1	1989	The expression of the c-myc oncogene was studied in paraffin-embedded specimens of cervical biopsies using a monoclonal antibody which binds to the 62,000 Dalton protein encoded by the c-myc gene.	Paraffin	52-60	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	22-27
29907895-0	2018	Feasibility of analysis of the SCN5A gene in paraffin embedded samples in sudden infant death cases at the Pretoria Medico-Legal Laboratory, South Africa.	Paraffin	45-53	sodium voltage-gated channel alpha subunit 5	Homo sapiens	31-36
30015848-4	2018	In the present study, we evaluated the expression of AHR/HSP-90 in 25 formalin-fixed, paraffin-embedded human oral cancer specimens by IHC analysis.	Paraffin	86-94	heat shock protein 90 alpha family class A member 1	Homo sapiens	57-63
19722231-9	2009	CONCLUSION: TS genotyping on paraffin-embedded fixed tissues proved to be the most useful method for prediction of outcome of 5-FU treatment in patients with colorectal adenocarcinoma.	Paraffin	29-37	thymidylate synthetase	Homo sapiens	12-14
2467732-3	1989	An immunohistochemical study of ras p21 expression was carried out on paraffin sections of 54 human breast carcinomas using monoclonal antibodies to p21.	Paraffin	70-78	H3 histone pseudogene 16	Homo sapiens	36-39
19501877-5	2009	METHODS: Immunohistochemical methods were used to assess the tumor expression of B7-H1 and B7-H3 in paraffin-embedded tissues from 110 patients who had undergone partial or radical nephrectomy for renal AML and from 7 patients with LAM who had undergone lung biopsy.	Paraffin	100-108	CD274 molecule	Homo sapiens	81-96
19887478-0	2009	Gene expression profiling of paraffin-embedded primary melanoma using the DASL assay identifies increased osteopontin expression as predictive of reduced relapse-free survival.	Paraffin	29-37	secreted phosphoprotein 1	Homo sapiens	106-117
30174892-8	2018	Expression of PD-L1 and PD-L2 on cytoplasm in paraffin embedded tumor samples were analyzed by immunohistochemistry staining and scored with a semi-quantitative method.	Paraffin	46-54	CD274 molecule	Homo sapiens	14-19
29716546-0	2018	Staining of E-selectin ligands on paraffin-embedded sections of tumor tissue.	Paraffin	34-42	selectin E	Homo sapiens	12-22
29716546-6	2018	METHODS: In this study, we developed an immunohistochemical staining technique, using E-selectin-human Ig Fc chimera (E-Ig) to characterize the expression and localization of E-selectin binding sites on paraffin-embedded sections of different cancer tissue.	Paraffin	203-211	selectin E	Homo sapiens	86-96
2565087-12	1989	It is concluded that semiquantitative immunocytochemical analysis with anti-PCNA/cyclin antibodies may represent a simple, reproducible, yet powerful technique for the routine analysis of cell kinetic data in alcohol-fixed, paraffin-embedded tissue by the surgical pathologist.	Paraffin	224-232	proliferating cell nuclear antigen	Homo sapiens	76-80
29682176-3	2018	In this study, we assessed the expression of CTLA-4 both at mRNA and protein levels in paraffin embedded-tissues from patients with thymomas.	Paraffin	87-95	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	45-51
19481753-2	2009	METHODS AND RESULTS: The presence of HSP90 on 26 cryostat and 6 paraffin embedded sections of carotid atherosclerotic plaques was determined by immunohistochemistry and immunofluorescence.	Paraffin	64-72	heat shock protein 90 alpha family class A member 1	Homo sapiens	37-42
2565087-12	1989	It is concluded that semiquantitative immunocytochemical analysis with anti-PCNA/cyclin antibodies may represent a simple, reproducible, yet powerful technique for the routine analysis of cell kinetic data in alcohol-fixed, paraffin-embedded tissue by the surgical pathologist.	Paraffin	224-232	proliferating cell nuclear antigen	Homo sapiens	81-87
19535128-5	2009	Interphase fluorescence in situ hybridization analysis on paraffin sections, using a fusion probe for API2/MALT1, demonstrated 2 fusion signals in most nuclei, bringing the first documentation of a t(11;18)(q21;q21) in this exceptional primary disease location.	Paraffin	58-66	baculoviral IAP repeat containing 3	Homo sapiens	102-106
2713135-5	1989	The demonstration of desmin by the monoclonal antibody which was used on the formaldehyde-fixed, paraffin-embedded material is of particular value in the diagnosis of rhabdomyosarcoma.	Paraffin	97-105	desmin	Homo sapiens	21-27
19744347-4	2009	METHODS: Immunohistochemistry and immunocytochemistry were used to identify HSp17 in paraffin embedded ovarian malignant tumor specimens and peritoneal metastatic malignant cells.	Paraffin	85-93	heat shock protein family B (small) member 3	Homo sapiens	76-81
27362474-0	2018	Immunoreactivity of a Monoclonal Antibody to SS18-SSX Fusion Gene Product in Formalin-fixed Paraffin-embedded Synovial Sarcoma Tissue Section.	Paraffin	92-100	SSX family member 2B	Homo sapiens	50-53
2462857-2	1989	Therefore, we evaluated the expression of p21 in formaldehyde-fixed, paraffin-embedded prostatic tissue using a commercially available polyclonal antiserum prepared in sheep.	Paraffin	69-77	H3 histone pseudogene 16	Homo sapiens	42-45
31043303-1	2018	INTRODUCTION: Evaluation of programmed cell death ligand-1 (PD-L1) on formalin-fixed paraffin-embedded (FFPE) histologic specimens is required for immunotherapy with pembrolizumab in non-small cell lung carcinoma (NSCLC).	Paraffin	85-93	CD274 molecule	Homo sapiens	28-58
31043303-1	2018	INTRODUCTION: Evaluation of programmed cell death ligand-1 (PD-L1) on formalin-fixed paraffin-embedded (FFPE) histologic specimens is required for immunotherapy with pembrolizumab in non-small cell lung carcinoma (NSCLC).	Paraffin	85-93	CD274 molecule	Homo sapiens	60-65
20095356-2	2009	METHODS: Immunohistochemistry (PV6000 method) was used to detect the expressions of cyclinB1, FHIT and Ki-67 in paraffin-embedded gastric carcinoma tissues of 336 cases and paracancerous normal mucosa of 60 cases.	Paraffin	112-120	cyclin B1	Homo sapiens	84-92
19450871-4	2009	METHODS: The expression of uPA/uPAR was examined on paraffin-embedded tissue sections from primary EOC (n=100), and matched metastatic lesions (n=30) of untreated patients, normal ovarian tissues (n=20) as well as 8 primary and metastatic EOC cell lines by immunohistochemistry.	Paraffin	52-60	plasminogen activator, urokinase receptor	Homo sapiens	31-35
19274762-6	2009	Oct 3/4 protein expression was studied by immunohistochemistry on paraffin sections using two different antibodies.	Paraffin	66-74	POU class 5 homeobox 1	Homo sapiens	0-7
28829151-3	2017	OBJECTIVES: - To validate a novel anti-CD155 antibody for immunohistochemistry and develop a robust, reliable, and specific protocol for detecting CD155 expression in glioblastoma formalin-fixed, paraffin-embedded (FFPE) tissue samples.	Paraffin	196-204	PVR cell adhesion molecule	Homo sapiens	147-152
3053056-1	1988	By means of in situ hybridization using biotinylated oncogene probes and the immunohistochemical reaction of avidin-biotin complex-alkaline phosphatase with substrate, we investigated expression of c-myc oncogene in the formalin-fixed, paraffin-embedded tissue sections from seven patients with squamous cell carcinoma (six cases) and small cell carcinoma (one case) of primary lung origin.	Paraffin	236-244	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	198-203
28922567-7	2017	METHODS: PD-L1 expression was determined by a commercially available antibody (clone 28-8) in 74 formalin-fixed, paraffin-embedded cell blocks from body effusions obtained at diagnosis from patients with MM.	Paraffin	113-121	CD274 molecule	Homo sapiens	9-14
29122010-5	2017	Nav1.5 and ER-beta expression was detected by using immunohistochemistry (IHC) on tissue microarray constructed from paraffin-embedded specimens.	Paraffin	117-125	sodium voltage-gated channel alpha subunit 5	Homo sapiens	0-6
19262251-5	2009	HMGA2 immunoreactivity was evaluated on archival paraffin sections and the results confirmed by Western blotting on 12 fresh tumor samples.	Paraffin	49-57	high mobility group AT-hook 2	Homo sapiens	0-5
3183353-3	1988	In this study, anti-HBs and anti-HBc were looked for in paraffin sections of liver biopsies from 16 patients with chronic type B hepatitis, all seropositive for HBeAg.	Paraffin	56-64	keratin 88, pseudogene	Homo sapiens	33-36
19538887-2	2009	METHODS: Immunohistochemistry was performed to detect the expression of THY1 gene in formalin-fixed, paraffin-embedded specimens of normal ovaries (n = 25), ovarian serous cystadenoma (n = 25), and serous cystadenocarcinoma (n = 53).	Paraffin	101-109	Thy-1 cell surface antigen	Homo sapiens	72-76
26663872-5	2017	METHODS: The EGFR gene was screened for mutations in exons 18, 19, 20 and 21 using direct sequencing of polymerase chain reaction products in DNA obtained from paraffin preserved cells from both tumors.	Paraffin	160-168	epidermal growth factor	Homo sapiens	13-17
3286224-9	1988	Immunolocalization of EGF in the mouse uterus was demonstrated only after paraffin sections were first briefly treated with pronase.	Paraffin	74-82	epidermal growth factor	Mus musculus	22-25
29025424-2	2017	METHODS: We developed a novel 4-color mIHC assay based on tyramide signal amplification that allowed us to reliably interrogate immunologic checkpoints, including programmed death-ligand 1 (PD-L1), cytotoxic T cells (CD8+T) and regulatory T cells (Foxp3), in formalin-fixed, paraffin-embedded tissues of various human gastric diseases.	Paraffin	275-283	baculoviral IAP repeat-containing 3	Mus musculus	38-42
19012699-3	2008	METHODS: We used immunohistochemical methods to examine the expression of hTERT and p53 proteins in 45 paraffin-embedded pathological samples of early stage (IA-IIA) cervical cancer.	Paraffin	103-111	telomerase reverse transcriptase	Homo sapiens	74-79
19173831-2	2008	METHODS: Immunohistochemistry (IHC) was used to detect the expression of DPPIV protein in 378 formalin-fixed paraffin-embedded EOC tissue samples.	Paraffin	109-117	dipeptidyl peptidase 4	Homo sapiens	73-78
2450069-2	1988	We have now studied melanomas from 30 patients for the presence of alpha 2M using the peroxidase anti-peroxidase technique on histologic sections from paraffin-embedded tissues and primary antibody raised against tumor-associated alpha 2M in rabbits.	Paraffin	151-159	alpha-2-macroglobulin	Homo sapiens	67-75
18369647-2	2008	An immunohistochemical study of c-MYC protein was performed in 140 paraffin-embedded astrocytic tumors of different grades.	Paraffin	67-75	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	32-37
3266335-2	1988	The monoclonal antibodies LN1, LN2, and L26 have been recently developed to recognize B-cell-specific antigens that survive routine tissue processing and paraffin embedding.	Paraffin	154-162	phytanoyl-CoA 2-hydroxylase	Homo sapiens	26-29
17912630-1	2008	BACKGROUND: The aims of this study were to define the distribution of caveolin 2 (CAV2) in frozen and formalin fixed, paraffin embedded (FFPE) normal breast samples and the significance of CAV2 expression in breast cancer.	Paraffin	118-126	caveolin 2	Homo sapiens	70-80
28477388-6	2017	Direct sequencing for H3F3A mutations in coding regions between codons 1 and 42, including the hotspot codons (28, 35, and 37), was performed on DNA extracted from formalin-fixed paraffin-embedded tissue.	Paraffin	179-187	H3.3 histone A	Homo sapiens	22-27
17912630-1	2008	BACKGROUND: The aims of this study were to define the distribution of caveolin 2 (CAV2) in frozen and formalin fixed, paraffin embedded (FFPE) normal breast samples and the significance of CAV2 expression in breast cancer.	Paraffin	118-126	caveolin 2	Homo sapiens	82-86
3327455-2	1987	The previously described monoclonal antibody Myc1-9E10 (1) which recognizes the p62 c-myc protein was used in paraffin tissue sections.	Paraffin	110-118	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	84-89
18451222-8	2008	CONCLUSIONS: We developed and validated a five-gene reverse transcription PCR assay for MGI suitable for analyzing routine formalin-fixed paraffin-embedded clinical samples.	Paraffin	138-146	CMS1A1	Homo sapiens	88-91
28716437-4	2017	METHODS: PD-L1 expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 100 patients with cSCC.	Paraffin	66-74	CD274 molecule	Homo sapiens	9-14
28927067-3	2017	miR-146a was evaluated in formalin-fixed, paraffin-embedded samples.	Paraffin	42-50	microRNA 146a	Homo sapiens	0-8
2442087-4	1987	Immunocytochemical staining of paraffin sections with monoclonal antibodies UCHL1 (T-lymphocyte membrane antigen) and LN-1, LN-2 and LN-3 (B-lymphocyte and Ia antigens) showed that central cells in LGC and lymphoid aggregates stained like follicular centre B-lymphocytes.	Paraffin	31-39	phytanoyl-CoA 2-hydroxylase	Homo sapiens	83-128
18478931-2	2007	METHODS: NET-1 gene protein expression was detected by Western blot, fluorescence immunocytochemistry, confocal laser scanning microscopy and immunohistochemistry in 8 cases of HCC tissues, human hepatoma cell line SMMC-7721, and paraffin-embeded sections from 130 cases of HCC.	Paraffin	230-238	neuroepithelial cell transforming 1	Homo sapiens	9-14
3902538-5	1985	The ABC technique on paraffin sections produced positive staining for oncomodulin throughout the placenta, with the most intense staining occurring in the outer placenta (cytotrophoblast and giant cells of the basal zone).	Paraffin	21-29	oncomodulin	Rattus norvegicus	70-81
18179742-2	2007	In this study we investigated differential expression of MMP-7 in the epithelium and stroma of 95 paraffin-embedded renal tumor samples by immunohistochemistry and compared tumoral with normal peritumoral renal tissue.	Paraffin	98-106	matrix metallopeptidase 7	Homo sapiens	57-62
28727276-4	2017	Paraffin-embedded lung tissue samples were used to detect miRNA-21 and miRNA-155.	Paraffin	0-8	microRNA 21	Homo sapiens	58-66
28299580-2	2017	METHODS: The expression of histone deacetylase 7 (HDAC7) was detected in paraffin-embedded gastric cancer samples from 86 patients by immunohistochemistry, and the differences in the expression of HDAC7 between cancerous and corresponding adjacent noncancerous tissues were compared using the Wilcoxon matched-pairs signed rank test.	Paraffin	73-81	histone deacetylase 7	Homo sapiens	27-48
28299580-2	2017	METHODS: The expression of histone deacetylase 7 (HDAC7) was detected in paraffin-embedded gastric cancer samples from 86 patients by immunohistochemistry, and the differences in the expression of HDAC7 between cancerous and corresponding adjacent noncancerous tissues were compared using the Wilcoxon matched-pairs signed rank test.	Paraffin	73-81	histone deacetylase 7	Homo sapiens	50-55
3887032-4	1985	We recently reported two MoAbs, LN-1 and LN-2, that react with B cells in paraffin sections.	Paraffin	74-82	phytanoyl-CoA 2-hydroxylase	Homo sapiens	32-45
27151584-6	2017	Paraffin sections from xenograft tumor specimens were used in the TUNEL (terminal deocynucleotide transferase dUTP nick end labeling) assay and an immunohistochemistry assay to detect cell proliferation markers Ki67 and PCNA.	Paraffin	0-8	proliferating cell nuclear antigen	Homo sapiens	220-224
17764580-4	2007	Genomic DNA from the paraffin embedded 39 thymoma tissues (A 6, AB 11, B1 7, B2 7, B3 8) labeled with Cy-3 was co-hybridized with the reference placenta gDNA labeled with Cy-5.	Paraffin	21-29	immunoglobulin kappa variable 3D-25 (pseudogene)	Homo sapiens	59-87
17721184-0	2007	Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): an ancillary diagnostic tool.	Paraffin	39-47	catenin beta 1	Homo sapiens	13-25
3887032-8	1985	We now report the use of LN-1, LN-2, and LN-3 in the analysis of paraffin sections from 58 non-Hodgkin"s lymphomas and 15 cases of Hodgkin"s disease.	Paraffin	65-73	phytanoyl-CoA 2-hydroxylase	Homo sapiens	25-29
17721184-4	2007	The aim of this study was to determine the specificity and sensitivity of these 3 most common beta-catenin mutations in the diagnosis of desmoid-type fibromatosis using paraffin-embedded material.	Paraffin	169-177	catenin beta 1	Homo sapiens	94-106
6376628-0	1984	Two new monoclonal antibodies (LN-1, LN-2) reactive in B5 formalin-fixed, paraffin-embedded tissues with follicular center and mantle zone human B lymphocytes and derived tumors.	Paraffin	74-82	phytanoyl-CoA 2-hydroxylase	Homo sapiens	31-35
18210878-4	2007	To determine the expression of OPN protein in the tumor tissues, immunohistochemical (IHC) staining was subsequently carried out on paraffin-embedded sections in tissue microarrays containing 662 samples derived from NSCLC cases.	Paraffin	132-140	secreted phosphoprotein 1	Homo sapiens	31-34
17845763-3	2007	RT-PCR Detection of the SYT-SSX fusion gene was performed using paraffin embedded tissue samples.	Paraffin	64-72	SSX family member 2B	Homo sapiens	28-31
28632845-2	2017	Methods: We investigated knock-in mice heterozygous for the SHORT syndrome mutation changing arginine 649 to tryptophan in p85alpha (PIK3R1) using physical examination, optical coherence tomography (OCT), tonometry, and histopathologic sections from paraffin-embedded eyes, and compared the findings to similar investigations in two human subjects with SHORT syndrome heterozygous for the same mutation.	Paraffin	250-258	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	123-131
28471195-13	2017	CONCLUSION: During development of PLA method for detection of protein complexes between p53 family members we detected interactions of p53 and p63 with T-antigen and mut-p53 and DeltaNp63 with TAp73 tumour suppressor in tumour cell lines and p53 tetramers in paraffin sections of colorectal cancer tissue.	Paraffin	259-267	tumor protein p63	Homo sapiens	143-146
28260090-5	2017	Immunohistochemical analyses of osteosarcoma tissue samples from two independent cohorts of formaldehyde-fixed, paraffin-embedded osteosarcoma tissue samples from total of 186 osteosarcoma patients showed that high ACTL6A expression correlated with malignant clinicopathological features such as larger tumor size, high Ennecking grade, high histologic grade, and advanced tumor node metastasis stage.	Paraffin	112-120	actin like 6A	Homo sapiens	215-221
17552912-0	2007	Selection of vimentin-specific antibodies from the HuCAL phage display library by subtractive panning on formalin-fixed, paraffin-embedded tissue.	Paraffin	121-129	vimentin	Homo sapiens	13-21
6376628-1	1984	Two monoclonal antibodies (LN-1, LN-2) reactive with B lymphocytes in B5 formalin-fixed, paraffin-embedded tissue sections have been produced by utilizing cell extracts from pokeweed mitogen-stimulated peripheral blood lymphocytes and diffuse histiocytic lymphoma SU-DHL-4 cells, respectively.	Paraffin	89-97	phytanoyl-CoA 2-hydroxylase	Homo sapiens	27-31
6376628-6	1984	Immunoperoxidase staining of sections from B5-fixed, paraffin-embedded human lymphoid tissues showed that LN-1 bound to the cell membrane and cytoplasm of germinal center cells whereas LN-2 stained the nuclear membrane and cytoplasm of germinal center and mantle zone B lymphocytes as well as interfollicular histiocytes and thymic medullary dendritic cells.	Paraffin	53-61	phytanoyl-CoA 2-hydroxylase	Homo sapiens	106-110
6376628-13	1984	Because of their high specificity for B cell tumors and their ability to stain B5-fixed, paraffin-embedded tissues, LN-1 and LN-2 are useful reagents for the diagnosis and classification of the human lymphomas and leukemias.	Paraffin	89-97	phytanoyl-CoA 2-hydroxylase	Homo sapiens	116-129
6326692-2	1984	A sensitive immunoperoxidase method employs a new chicken anti-B2-microglobulin (B2M) antibody for use on paraffin sections.	Paraffin	106-114	beta-2-microglobulin	Homo sapiens	58-79
17473196-10	2007	CONCLUSIONS: Whereas the collection of fresh-frozen tumor samples remains a major challenge in large clinical trials, routinely processed paraffin-embedded tissue samples can be used to quantitate the prognostic biological markers trkC and c-myc.	Paraffin	138-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	240-245
17342325-4	2007	We analyzed the expression of the TKTL1 protein in a retrospective institution-based patient cohort with invasive breast cancer by immunohistochemical analysis of 124 paraffin-embedded breast cancer tissues.	Paraffin	167-175	transketolase like 1	Homo sapiens	34-39
28073897-0	2017	Identification of ALK, ROS1, and RET Fusions by a Multiplexed mRNA-Based Assay in Formalin-Fixed, Paraffin-Embedded Samples from Advanced Non-Small-Cell Lung Cancer Patients.	Paraffin	98-106	ret proto-oncogene	Homo sapiens	33-36
6326692-2	1984	A sensitive immunoperoxidase method employs a new chicken anti-B2-microglobulin (B2M) antibody for use on paraffin sections.	Paraffin	106-114	beta-2-microglobulin	Homo sapiens	81-84
6318562-1	1984	Z-protein, a new muscle protein with a molecular weight of 55,000 daltons recently discovered in Japan, is an excellent marker for muscle differentiation in paraffin sections.	Paraffin	157-165	transmembrane BAX inhibitor motif containing 4	Homo sapiens	0-9
28474069-2	2017	METHODS: The expression of DACH1 was detected immunohistochemistrically in 51 samples of paraffin-embedded TSCC, paired adjacent tissues and 25 samples of atypical hyperplasia tissues of the tongue.	Paraffin	89-97	dachshund family transcription factor 1	Homo sapiens	27-32
17454857-3	2007	MATERIAL AND METHODS: TS expression was determined immunohistochemically in paraffin-embedded biopsies of PT-M pairs in 39 CRC patients, as related to the clinical data.	Paraffin	76-84	thymidylate synthetase	Homo sapiens	22-24
6192256-2	1983	Prostatic origin of these carcinomas was confirmed by immunocytochemical demonstration of prostatic acid phosphatase and prostate specific antigen within paraffin sections.	Paraffin	154-162	kallikrein related peptidase 3	Homo sapiens	121-146
17332286-7	2007	For ovarian cancer patients being treated with letrozole, we tested the predictive value of the IGFBPs in paraffin-fixed sections from their primary tumors by semiquantitative immunohistochemistry.	Paraffin	106-114	insulin like growth factor binding protein 1	Homo sapiens	96-102
16977458-3	2007	METHODS: Fluorescent in situ hybridization was used to analyse the C-MYC and CDKN2A genes on isolated nuclei from 49 paraffin-embedded primary NMs.	Paraffin	117-125	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	67-72
27539594-6	2017	METHODS: Immunohistochemistry for modified tau (phosphorylated at Ser199-202-Thr205 labelled by the antibody AT8) was performed on paraffin-embedded human brain sections providing a detailed characterization of NFT pathology.	Paraffin	131-139	microtubule associated protein tau	Homo sapiens	43-46
27818595-3	2016	Expression of COX-2 and EP1 receptor was examined by immunohistochemistry of formalin-fixed, paraffin-embedded tissues using polyclonal antibodies.	Paraffin	93-101	prostaglandin E receptor 1	Homo sapiens	24-27
7042818-0	1982	Demonstration of lactoperoxidase in paraffin-embedded lactating bovine breast by immunocytochemical techniques.	Paraffin	36-44	lactoperoxidase	Bos taurus	17-32
27570060-3	2016	METHODS: The expression of GPR109A was examined by antibody staining and in situ hybridization on pancreatic paraffin sections.	Paraffin	109-117	hydroxycarboxylic acid receptor 2	Mus musculus	27-34
17390111-5	2007	CCL2 production was assessed in paraffin embedded tumour samples by immunohistochemistry.	Paraffin	32-40	C-C motif chemokine ligand 2	Homo sapiens	0-4
17153776-0	2006	Detection of the t(11;18) API2/MALT1 translocation associated with gastric MALT lymphoma in routine formalin-fixed, paraffin-embedded small endoscopic biopsy specimens by robust real-time RT-PCR.	Paraffin	116-124	baculoviral IAP repeat containing 3	Homo sapiens	26-30
16938384-7	2006	Similar patterns of zHSF1a and zHSF2 mRNA expression in the brain regions of developing zebrafish were detected by whole mount in situ hybridization and paraffin sectioning, suggesting that most of the two HSF gene activities were controlled by a common mechanism during the embryonic development of zebrafish.	Paraffin	153-161	heat shock transcription factor 1	Danio rerio	20-26
7011098-1	1980	The distribution of the glycoprotein, fibronectin, within the cranial region of stage 8--16 chick embryos was examined by indirect immunofluorescence using paraffin sections exposed to affinity-purified rabbit anti-human CIG and FITC-conjugated goat anti-rabbit immunoglobulins.	Paraffin	156-164	fibronectin 1	Gallus gallus	38-49
27683879-6	2016	The modified procedures were applied to paraffin sections of a mouse model (APP/PS1) of Alzheimer"s disease.	Paraffin	40-48	amyloid beta (A4) precursor protein	Mus musculus	76-83
6991056-2	1980	The peroxidase-antiperoxidase immunohistochemical method was then used to demonstrate the localization of choline acetyltransferase in formalin-fixed and paraffin-embedded human cerebellum from normal as well as from Huntington"s disease brains.	Paraffin	154-162	LOW QUALITY PROTEIN: choline O-acetyltransferase	Oryctolagus cuniculus	106-131
27174194-1	2016	AIMS: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters METHODS: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks.	Paraffin	261-269	MYB proto-oncogene, transcription factor	Homo sapiens	16-19
27174194-1	2016	AIMS: To detect MYB gene breaks in adenoid cystic carcinoma (ACC) of the salivary glands and its correlation with prognosis and selected clinical parameters METHODS: MYB gene break was detected by FISH assay in 23 adenoid cystic carcinomas using formalin-fixed paraffin-embedded blocks.	Paraffin	261-269	MYB proto-oncogene, transcription factor	Homo sapiens	166-169
17117940-4	2006	Immunohistochemical staining of paraffin sections showed that PRDX5 expression was mainly localised to the axon and, to a lesser extent, to the Schwann cells.	Paraffin	32-40	peroxiredoxin 5	Homo sapiens	62-67
17177840-5	2006	In the current study, the expression of galectin-1 was examined in 80 formalin-fixed, paraffin-embedded cervical tissues: 20 benign cervical specimen, 20 low-grade squamous intraepithelial lesions (LGSIL), 20 high-grade squamous intraepithelial lesions (HGSIL), and 20 invasive squamous cell carcinomas (ISCC).	Paraffin	86-94	galectin 1	Homo sapiens	40-50
16827883-3	2006	Mannan-binding lectin genotypes were identified with polymerase chain reaction on stored samples of stem cells or formalin-fixed paraffin-embedded bone marrow biopsies.	Paraffin	129-137	mannose binding lectin 2	Homo sapiens	0-21
88176-1	1979	A method is described whereby commercially available radioimmunoassay-grade antibodies specific for the polypeptide hormones calcitonin, gastrin, glucagon, and somotastatin are used to detect these antigens on paraffin sections of routinely fixed tissue.	Paraffin	210-218	gastrin	Homo sapiens	137-144
16133023-2	2006	METHODS: The expression patterns of hTR and hTRT were detected by in situ hybridization (ISH) in paraffin-embedded samples of 55 eyelid sebaceous gland carcinoma, 12 chalazia, and four sebaceous adenoma.	Paraffin	97-105	telomerase reverse transcriptase	Homo sapiens	44-48
27373711-1	2016	On-tissue digestion matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) can be used to record spatially correlated molecular information from formalin-fixed, paraffin-embedded (FFPE) tissue sections.	Paraffin	188-196	RB binding protein 4, chromatin remodeling factor	Homo sapiens	97-100
378382-7	1979	Based on the treatment of serial paraffin sections with various antisera, it was clearly shown that MSH, ACTH, and LPH occur in the same cells located in the pars distalis as in the pars intermedia.	Paraffin	33-41	lactase	Rattus norvegicus	115-118
27223861-3	2016	DESIGN: In laboratories at the University of Ferrara, Ferrara, Italy, IRF6 gene expression and promoter methylation were investigated in paraffin-embedded VSCC and adjacent vulvar intraepithelial neoplasia (VIN) and VLS specimens, in cancer-free VLS (cfVLS) specimens, and in healthy skin specimens by reverse transcriptase-quantitative polymerase chain reaction (RT-qPCR) analysis and by sequencing of PCR-amplified bisulfite-treated DNA.	Paraffin	137-145	interferon regulatory factor 6	Homo sapiens	70-74
27390597-4	2016	MATERIALS AND METHODS: Immunochemistry was used to evaluate FADS1 expressions in 216 paraffin-embedded specimens.	Paraffin	85-93	fatty acid desaturase 1	Homo sapiens	60-65
16445768-7	2006	In vivo expression of Tob gene product in the epidermis was determined by immunohistochemistry with paraffin sections.	Paraffin	100-108	transducer of ERBB2, 1	Homo sapiens	22-25
16321826-3	2006	CD56 expression was evaluated by immunohistochemistry on bone marrow paraffin embed specimens from 107 MM cases undergoing Melphalan-based high dose therapy and ASCT.	Paraffin	69-77	neural cell adhesion molecule 1	Homo sapiens	0-4
760368-1	1979	Immunocytochemical localization of GFA protein in formalin-fixed, paraffin-embedded tissue sections by the peroxidase-antiperoxidase method of Sternberger was used to study experimental murine CNS tumors.	Paraffin	66-74	glutamine fructose-6-phosphate transaminase 1	Mus musculus	35-38
16220294-1	2006	Hepatocyte paraffin 1 (Hep Par 1) and neprilysin (CD10) are well-known markers of hepatocellular carcinoma (HCC).	Paraffin	11-19	Prader Willi/Angelman region RNA 1	Homo sapiens	27-32
16210018-7	2005	MAIN OUTCOME MEASURE(S): Matrix metalloproteinase 1, ERalpha, and ERbeta protein expression in paraffin-embedded tissue biopsies was measured by IHC.	Paraffin	95-103	matrix metallopeptidase 1	Homo sapiens	25-51
27283076-6	2016	High expression of the PKM2 was detected in 55.71% paraffin-embedded GBC tissue.	Paraffin	51-59	pyruvate kinase M1/2	Homo sapiens	23-27
348269-2	1978	We used the peroxidase-antiperoxidase immunohistochemical method to demonstrate the localization of choline acetyltransferase in formalin-fixed and paraffin-embedded sections of rabbit spinal cord and cerebellum.	Paraffin	148-156	LOW QUALITY PROTEIN: choline O-acetyltransferase	Oryctolagus cuniculus	100-125
26547800-4	2016	METHODS: K14 expression was analyzed by immunohistochemistry on paraffin-embedded tissue sections of 17 healthy individuals and 58 patients with ASD.	Paraffin	64-72	keratin 14	Homo sapiens	9-12
16021514-7	2005	Reverse transcription-polymerase chain reaction analysis performed on paraffin-embedded tissue showed EWS-ATF1 fusion transcripts representative of the t(12;22) (q13;q12) clear cell sarcoma reciprocal translocation.	Paraffin	70-78	activating transcription factor 1	Homo sapiens	102-110
321699-1	1977	Treatment of dewaxed sections of formalin-fixed paraffin embedded material with 0.1% pronase for 15 min at 37 degrees C prior to the performance of the unlabelled antibody-enzyme (PAP) procedure greatly enhanced its sensitivity.	Paraffin	48-56	regenerating family member 3 alpha	Homo sapiens	180-183
16261889-5	2005	Goblet cells were identified by AB/PAS staining and the expression of MUC5AC in the paraffin"s section was tested by immunohistochemistry.	Paraffin	84-92	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	70-76
27115465-4	2016	METHODS: CXCL14 mRNA expression was analysed in a breast cancer tissue microarray (TMA) of formalin-fixed, paraffin-embedded tumours by the RNAscope 2.0 Assay.	Paraffin	107-115	chemokine (C-X-C motif) ligand 14	Mus musculus	9-15
168283-10	1975	Furthermore, specific uptake of HPL was observed on the alveolar cell membranes after the incubation of paraffin-embedded sections of formalin-fixed mammary gland and subsequent treatment by the peroxidase-labelled antibody method.	Paraffin	104-112	galectin 1	Homo sapiens	32-35
27081037-3	2016	We further detected TRIM29 protein with immunohistochemistry in 150 paraffin-embedded samples from early-stage cervical cancer patients.	Paraffin	68-76	tripartite motif containing 29	Homo sapiens	20-26
16179839-5	2005	METHODS: We conducted an immunohistochemical investigation of PTEN and VEGF expression in 90 cases of paraffin section obtained from gastric cancer patients undergone surgical treatment.	Paraffin	102-110	phosphatase and tensin homolog	Homo sapiens	62-66
16115927-4	2005	EXPERIMENTAL DESIGN: Immunohistochemistry was used to detect active, nuclear Stat5 in 357 paraffin-embedded prostate cancer specimens on a tissue microarray with clinical follow-up data.	Paraffin	90-98	signal transducer and activator of transcription 5A	Homo sapiens	77-82
15861408-7	2005	Additionally, among the extracellular matrix proteins analyzed, expression of fibronectin was elevated in the RXRalpha-/- as assessed by immunostaining in paraffin-embedded sections and proepicardial explants.	Paraffin	155-163	fibronectin 1	Mus musculus	78-89
26513623-3	2016	We evaluated the utility of a monoclonal antibody directed against glypican 3 (GPC-3), a membrane bound protein involved in regulation of the signaling of Wingless-types (WNTs), Hedgehogs (Hh), Fibroblast Growth Factors (FGFs), and Bone Morphogenetic Proteins (BMPs), in the detection of ganglion cells in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	322-330	glypican 3	Homo sapiens	67-77
26513623-3	2016	We evaluated the utility of a monoclonal antibody directed against glypican 3 (GPC-3), a membrane bound protein involved in regulation of the signaling of Wingless-types (WNTs), Hedgehogs (Hh), Fibroblast Growth Factors (FGFs), and Bone Morphogenetic Proteins (BMPs), in the detection of ganglion cells in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	322-330	glypican 3	Homo sapiens	79-84
26513623-8	2016	CONCLUSIONS: The present study indicates that monoclonal anti-GPC-3 might prove to be useful immunohistochemical marker in the identification of ganglion cells in paraffin-embedded rectal tissue specimens and suction biopsies.	Paraffin	163-171	glypican 3	Homo sapiens	62-67
15734549-6	2005	The precise localization of CD29 protein in paraffin-embedded tissues was detected by using a specific polyclonal antibody indicating that its expression is limited to smooth muscle, epithelium cells, endothelium of blood vessels and myeloid cells and is no detectable in cells of the lymphoid lineage.	Paraffin	44-52	integrin subunit beta 1	Sus scrofa	28-32
24504468-1	1969	The distribution of ATP-ase and other nucleotide phosphatases has been studied in young root tips of maize, barley and broad bean using frozen and paraffin sections stained by standard lead sulphide precipitation procedures.	Paraffin	147-155	ATPase	Zea mays	20-27
15896802-7	2005	To overcome this limitation, we have developed a simple and reproducible method to generate APM component-specific mAb which stain formalin-fixed, paraffin-embedded tissue sections.	Paraffin	147-155	alanyl (membrane) aminopeptidase	Mus musculus	92-95
15896802-9	2005	The use of the methodology we have developed resulted in the generation of a panel of APM component-specific mAb capable of staining formalin-fixed, paraffin-embedded tissue sections in IHC reactions.	Paraffin	149-157	alanyl (membrane) aminopeptidase	Mus musculus	86-89
15722793-4	2005	In this study, the immunohistochemical expression of the deleted in colorectal cancer gene (DCC) and p27Kip1 was assessed in 168 paraffin-embedded, formalin-fixed tumors of patients with stage II and III colorectal cancer.	Paraffin	129-137	cyclin dependent kinase inhibitor 1B	Homo sapiens	101-108
32661670-6	2021	MYB IHC was performed on slides made from cytology cell block and surgical resection paraffin blocks.	Paraffin	85-93	MYB proto-oncogene, transcription factor	Homo sapiens	0-3
15757867-3	2005	METHODS: Gene expression of SOCS-1, -2 and -3 was evaluated by RT-PCR in untreated and cytokine-treated isolated human pancreatic islets and their protein expression by immunohistochemistry in control and in type 1 diabetic human pancreata paraffin-embedded sections.	Paraffin	240-248	suppressor of cytokine signaling 1	Homo sapiens	28-45
26974561-0	2016	Characterization of a Novel Anti-Human HB-EGF Monoclonal Antibody Applicable for Paraffin-Embedded Tissues and Diagnosis of HB-EGF-Related Cancers.	Paraffin	81-89	heparin binding EGF like growth factor	Homo sapiens	39-45
26498465-3	2016	HuR and COX-2 proteins" expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 98 patients with benign (n = 48) and malignant (n = 50) lesions and was statistically analyzed with clinicopathological parameters, follicular cells" proliferative capacity and recurrence risk rate.	Paraffin	73-81	ELAV like RNA binding protein 1	Homo sapiens	0-3
32857249-3	2021	We carried out a preliminary evaluation of MYB-NFIB translocation by fluorescence in-situ hybridization on seven archived formalin-fixed paraffin-embedded tissues of AdCC of Nigerian patients and its clinicopathologic features.	Paraffin	137-145	MYB proto-oncogene, transcription factor	Homo sapiens	43-46
27073721-3	2016	The expression of flotillin-1 protein was detected by IHC staining in a large cohort of 308 paraffin-embedded cervical cancer tissues.	Paraffin	92-100	flotillin 1	Homo sapiens	18-29
15749593-4	2005	After DNA extraction from paraffin-embedded tissues, the promoter region of the TS gene was amplified by polymerase chain reaction.	Paraffin	26-34	thymidylate synthetase	Homo sapiens	80-82
33508625-2	2021	METHODS: FNDC5/irisin was identified in sections of paraffin embedded rat maxillae, cryo-sections of 3D cultured spheroids hPDL cells, hDPCs and hOBs, 2D cultured hPDL cells, hDPCs and hOBs by immunohistochemistry.	Paraffin	52-60	fibronectin type III domain containing 5	Rattus norvegicus	9-14
15628907-6	2005	DESIGN: We developed an assay and analyzed the gene copy numbers of the erb-B2 and TOP2A genes in 8 breast cancer cell lines, 6 fresh frozen samples, and 38 paraffin-embedded breast tumor specimens by a novel real-time polymerase chain reaction (PCR) assay using hybridization probes.	Paraffin	157-165	DNA topoisomerase II alpha	Homo sapiens	83-88
15628907-10	2005	Finally, we observed that TOP2A amplification only occurred in conjunction with erb-B2 amplification in our paraffin-embedded cases of invasive breast carcinoma and that this event was present in 5 (42%) of 12 erb-B2 amplified cases.	Paraffin	108-116	DNA topoisomerase II alpha	Homo sapiens	26-31
26268359-4	2015	We tested KIF5B-RET translocation in Formalin Fixed Paraffin Embedded using fluorescence in situ hybridization.	Paraffin	52-60	ret proto-oncogene	Homo sapiens	16-19
25716692-9	2015	The expression levels of BPTF and vimentin in CRC paraffin-embedded specimens were significantly higher than the expression in NATs (P &lt; 0.01), while the expressions of E-cadherin in tumors were obviously lower than in NATs (P &lt; 0.01).	Paraffin	50-58	vimentin	Homo sapiens	34-42
33508625-2	2021	METHODS: FNDC5/irisin was identified in sections of paraffin embedded rat maxillae, cryo-sections of 3D cultured spheroids hPDL cells, hDPCs and hOBs, 2D cultured hPDL cells, hDPCs and hOBs by immunohistochemistry.	Paraffin	52-60	fibronectin type III domain containing 5	Homo sapiens	15-21
25953218-5	2015	Moreover, microRNA-21 expression was quantified in formalin-fixed paraffin-embedded biopsies from this cohort, and the results obtained were correlated with clinical and molecular characteristics, pathological response, and outcome.	Paraffin	66-74	microRNA 21	Homo sapiens	10-21
15363040-10	2004	Expression of API2-MALT1 fusion transcripts was detected by reverse transcription-polymerase chain reaction analysis using formalin-fixed, paraffin-embedded tissue.	Paraffin	139-147	baculoviral IAP repeat containing 3	Homo sapiens	14-18
33561783-4	2021	METHODS: Expression of urokinase plasminogen activator receptor (uPAR) and epithelial cell adhesion molecule (EpCAM) are determined on paraffin-embedded human UCC using immunohistochemistry and on UCC cell lines by flow cytometry.	Paraffin	135-143	plasminogen activator, urokinase receptor	Homo sapiens	23-63
15248926-2	2004	The purpose of this study was to evaluate the relationship of the cisplatin sensitivity/prognosis with the expression of excision repair cross complement-1 (ERCC-1), metallothionein (MT), and p53 in the paraffin-embedded tissue of advanced non-small cell lung cancer (NSCLC).	Paraffin	203-211	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	121-155
15248926-2	2004	The purpose of this study was to evaluate the relationship of the cisplatin sensitivity/prognosis with the expression of excision repair cross complement-1 (ERCC-1), metallothionein (MT), and p53 in the paraffin-embedded tissue of advanced non-small cell lung cancer (NSCLC).	Paraffin	203-211	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	157-163
33561783-4	2021	METHODS: Expression of urokinase plasminogen activator receptor (uPAR) and epithelial cell adhesion molecule (EpCAM) are determined on paraffin-embedded human UCC using immunohistochemistry and on UCC cell lines by flow cytometry.	Paraffin	135-143	plasminogen activator, urokinase receptor	Homo sapiens	65-69
33573562-3	2021	OBJECTIVE: The present study aimed to investigate Microtubule-Actin Cross-Linking Factor 1 (MACF1) expression in SOC tissues (including paraffin-embedded and fresh tissues) and to assess its expression and significant value in patients with SOC.	Paraffin	136-144	microtubule actin crosslinking factor 1	Homo sapiens	50-90
15272534-1	2004	Hepatocyte paraffin 1 (Hep Par 1), a monoclonal antibody recognizing an antigen thought to be specific for hepatocyte mitochondria, is considered the most specific and sensitive marker of normal and neoplastic hepatocytes and has been used in diagnosing hepatocellular carcinomas.	Paraffin	11-19	Prader Willi/Angelman region RNA 1	Homo sapiens	27-32
15256115-1	2004	OBJECTIVE: To investigate the feasibility of detecting API2-MALT1 fusion gene transcript in paraffin-embedded tissue and its diagnostic value for pulmonary MALT lymphoma.	Paraffin	92-100	baculoviral IAP repeat containing 3	Homo sapiens	55-59
15256115-9	2004	CONCLUSION: Detection of API2-MALT1 fusion transcript in paraffin-embedded tissues is feasible by nested RT-PCR and is of diagnostic value.	Paraffin	57-65	baculoviral IAP repeat containing 3	Homo sapiens	25-29
24748501-5	2015	METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested methylation-specific PCR in 102 paraffin-embedded gastric cancer samples.	Paraffin	158-166	checkpoint with forkhead and ring finger domains	Homo sapiens	65-69
24748501-5	2015	METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested methylation-specific PCR in 102 paraffin-embedded gastric cancer samples.	Paraffin	158-166	mutL homolog 1	Homo sapiens	84-88
15096140-7	2004	The results of our study suggest that when paraffin-embedded specimens are investigated by immunohistochemical methods, CK5 antibody is useful in the diagnosis of LA and MA.	Paraffin	43-51	keratin 5	Homo sapiens	120-123
33573562-3	2021	OBJECTIVE: The present study aimed to investigate Microtubule-Actin Cross-Linking Factor 1 (MACF1) expression in SOC tissues (including paraffin-embedded and fresh tissues) and to assess its expression and significant value in patients with SOC.	Paraffin	136-144	microtubule actin crosslinking factor 1	Homo sapiens	92-97
32324631-8	2021	We analyzed FABP4 expression in a cohort of paraffin-embedded meningioma specimens by immunohistochemistry and double immunofluorescence analyses.	Paraffin	44-52	fatty acid binding protein 4	Homo sapiens	12-17
15026346-5	2004	SR-A immunohistochemical staining was performed on paraffin sections of normal prostate, prostatic intraepithelial neoplasia (PIN) lesions, and prostate cancers from radical prostatectomy specimens.	Paraffin	51-59	macrophage scavenger receptor 1	Homo sapiens	0-4
14694519-5	2004	In paraffin sections, cells that expressed IL-6 or MCP-1 were identified by combined in situ hybridization and immunohistochemistry.	Paraffin	3-11	C-C motif chemokine ligand 2	Homo sapiens	51-56
15103201-5	2004	RESULT: A specific chimeric gene, the SSX-SYT fusion gene, was identified in the formalin-fixed paraffin-embedded surgical specimen using the reverse-transcription polymerase chain reaction (RT-PCR) technique.	Paraffin	96-104	SSX family member 2B	Homo sapiens	38-41
25575713-4	2015	MATERIALS AND METHODS: The expression-and localization pattern of uPAR was investigated in formalin-fixed paraffin-embedded tumor tissue from 149 patients treated with radical cystectomy between 1988 and 2005.	Paraffin	106-114	plasminogen activator, urokinase receptor	Homo sapiens	66-70
25384402-7	2015	Paraffin slices were labeled with p38 mitogen-activated protein kinase (p38MAPK) and c-Jun N-terminal kinase (JNK) by immunofluorescence staining, and then were co-labeled with hexaribonucleotide binding protein-3 (NeuN), glial fibrillary acidic protein (GFAP) and anti-integrin alphaM (CD11b) antibody (OX-42) to explore the associations of p38MAPK and JNK with nerve cells or glial cell.	Paraffin	0-8	mitogen-activated protein kinase 8	Rattus norvegicus	85-108
34055379-7	2021	IDH1 R132H immunohistochemistry was performed on cases in which a paraffin block of the metastatic tumor could be retrieved.	Paraffin	66-74	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-4
25785098-3	2015	MATERIALS AND METHODS: Expression of MACC1 protein was detected immunohistochemically in paraffin-embedded specimens of 96 cases of colon cancer.	Paraffin	89-97	MET transcriptional regulator MACC1	Homo sapiens	37-42
26539529-3	2015	CB1 and CB2 proteins" expression was assessed immunohistochemically on paraffin-embedded thyroid tissues obtained from 87 patients with benign (n = 43) and malignant (n = 44) lesions and was statistically analyzed with clinicopathological parameters, follicular cells" proliferative capacity, and risk of recurrence rate estimated according to the American Thyroid Association (ATA) staging system.	Paraffin	71-79	cannabinoid receptor 2	Homo sapiens	8-11
14676162-7	2003	DESIGN: Analysis of uPAR expression by immunohistochemistry in paraffin sections from 20 keloids and 18 normal scars.	Paraffin	63-71	plasminogen activator, urokinase receptor	Homo sapiens	20-24
34055379-11	2021	In 3 out of 12 patients of which a paraffin block could be retrieved immunohistochemistry revealed an IDH1-mutant glioma.	Paraffin	35-43	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	102-106
33283646-3	2021	To this end, we generated a novel antibody that allowed the detection of CLDN14 in paraffin-embedded renal sections.	Paraffin	83-91	claudin 14	Mus musculus	73-79
14645698-2	2003	METHODS: The expression of nuclear beta catenin was studied by immunohistochemistry using paraffin wax embedded specimens.	Paraffin	90-102	catenin beta 1	Homo sapiens	35-47
25502083-6	2015	Finally, FOXP1 was validated at the protein level by immunohistochemistry in paraffin embedded ovarian tissues (i.e., for metastasis, 15 primary EOC and 10 omental metastasis [OM]; for chemoresistance, 13 sensitive and 13 resistant EOC).	Paraffin	77-85	forkhead box P1	Homo sapiens	9-14
24903677-7	2015	In conclusion, our results reassured the high specificity of annexin A1 and pERK, as well as the diagnostic value of standard HCL markers of CD11c, CD25, CD103, and CD123 also in paraffin-embedded BM samples.	Paraffin	179-187	integrin subunit alpha E	Homo sapiens	154-159
33683684-6	2021	Here we describe an automated immunohistochemistry staining procedure that can be applied for the validation of multiple anti-PD-L1 antibody clones when used for the staining of formalin-fixed, paraffin-embedded lung cancer tissue sections.	Paraffin	194-202	CD274 molecule	Homo sapiens	126-131
25515240-8	2014	DEK expression was determined by immunohistochemistry in 67 formalin-fixed paraffin-embedded tumour samples from metastatic colorectal cancer patients treated with irinotecan-based therapy as first-line treatment.	Paraffin	75-83	DEK proto-oncogene	Homo sapiens	0-3
14584072-4	2003	In addition, to validate gene expression data at the protein level, TADG-15 expression was evaluated by immunohistochemistry on paraffin embedded tissue from which all 11 primary tumor cell lines were established.	Paraffin	128-136	ST14 transmembrane serine protease matriptase	Homo sapiens	68-75
14584072-8	2003	Immunohistochemistry staining of paraffin embedded cervical carcinoma specimens confirmed TADG-15 expression in tumor cells and its absence on normal cervical epithelial cells.	Paraffin	33-41	ST14 transmembrane serine protease matriptase	Homo sapiens	90-97
33683685-5	2021	PD-L1 is a major immune checkpoint protein that mediates antitumor immune suppression and response, which is routinely detected using IHC in formalin-fixed and paraffin-embedded tissues as part of cancer clinical diagnostic workflows.	Paraffin	160-168	CD274 molecule	Homo sapiens	0-5
14636275-2	2003	METHODS AND RESULTS: Immunohistochemical staining for MCM7 was performed on 122 samples of paraffin-embedded trophoblastic tissues including 22 normal first-trimester placentas, 12 term placentas, 12 spontaneous miscarriages (SM), 21 partial moles (PM), 44 complete hydatidiform moles (CM), and 11 choriocarcinomas (CCA).	Paraffin	91-99	minichromosome maintenance complex component 7	Homo sapiens	54-58
33910421-6	2021	Immunohistochemistry staining of 127 paraffin-embedded breast cancer tissues showed that RBMS3 protein was localized in the cytoplasm and nucleus; however, nuclear staining was present in 90.0% of normal breast tissues but only 28.3% of breast cancer tissues.	Paraffin	37-45	RNA binding motif single stranded interacting protein 3	Homo sapiens	89-94
12802584-4	2003	To identify the role of DNase gamma in apoptotic foci of HNL paraffin embedded tissue sections of HNL and lymphadenopathy with hyperplastic germinal centers and paracortex in the neck lymph nodes were immunohistochemically stained for DNase gamma and the results compared with the reactivity of TdT-mediated dUTP nick end labeling (TUNEL).	Paraffin	61-69	deoxyribonuclease 1 like 3	Homo sapiens	24-35
25628943-3	2015	Using immunochemistry, protein level of Tbx3 and EMT markers (E-cadherin and N-cadherin) were identified in 150 pairs of paraffin-embedded specimen.	Paraffin	121-129	IL2 inducible T cell kinase	Homo sapiens	49-52
33241207-3	2020	Immunohistochemical staining of PD-L1 (Clone 22C3) was applied to the sections obtained from paraffin blocks.	Paraffin	93-101	CD274 molecule	Homo sapiens	32-37
25420961-8	2014	IHC staining of formalin-fixed paraffin-embedded sections with specific antibodies showed that aurora and stathmin are expressed in BC.	Paraffin	31-39	stathmin 1	Homo sapiens	106-114
12734658-4	2003	In the present study, we screened paraffin-embedded brain tissue from different areas of 18 cases (8 autopsy cases and 10 biopsies) for alterations in the TP53 and PTEN genes.	Paraffin	34-42	phosphatase and tensin homolog	Homo sapiens	164-168
32829070-4	2020	By using polyclonal FRalpha antibody on archival paraffin blocks immunohistochemistry was performed.	Paraffin	49-57	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	20-27
12670331-0	2003	Detection by the fluorescence in situ hybridization technique of MYC translocations in paraffin-embedded lymphoma biopsy samples.	Paraffin	87-95	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	65-68
12670331-2	2003	We report the analysis of paraffin sections from 36 B-cell lymphoma biopsies for MYC translocation breakpoints by FISH.	Paraffin	26-34	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	81-84
12769341-4	2003	Few investigators have attempted to detect immunoglobulin light chain (IgL) gene rearrangements by PCR using paraffin wax embedded samples.	Paraffin	109-121	immunoglobulin lambda locus	Homo sapiens	71-74
12576455-2	2003	EXPERIMENTAL DESIGN: Expression of p27(Kip1) was assessed by immunohistochemistry on formalin-fixed, paraffin-embedded bone marrow biopsies.	Paraffin	101-109	cyclin dependent kinase inhibitor 1B	Homo sapiens	39-43
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Paraffin	107-115	neural cell adhesion molecule 1	Homo sapiens	47-51
25674197-2	2014	METHODS: ERCC1 mRNA expression was quantified by quantitative real-time reverse-transcription PCR in paraffin-embedded non-small cell lung cancer (NSCLC; n = 357), gastric cancer (n = 106), and breast cancer (n = 363) tissues.	Paraffin	101-109	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	9-14
24635731-7	2014	RESULTS: Fluorescence in situ hybridization screening of paraffin-embedded formalin-fixed tissue indeed revealed the presence of an MLL rearrangement.	Paraffin	57-65	lysine methyltransferase 2A	Homo sapiens	132-135
32754325-2	2020	Reverse transcription-quantitative PCR was used to quantify the mRNA expression levels of HIF-1alpha, HIF-2alpha, prolyl hydroxylase (PHD)1, PHD2 and PHD3 in formalin-fixed paraffin-embedded (FFPE) tumour tissue samples from 41 patients with RCC, including 33 cases of clear cell RCC (ccRCC).	Paraffin	173-181	endothelial PAS domain protein 1	Homo sapiens	102-112
25203299-6	2014	We developed a novel RNA in situ hybridization-based assay for the in situ detection of ETV1, ETV4, and ETV5 in formalin-fixed paraffin-embedded tissues from prostate needle biopsies, prostatectomy, and metastatic PCa specimens using RNA probes.	Paraffin	127-135	ETS variant transcription factor 5	Homo sapiens	104-108
25232405-5	2014	pIgR expression was evaluated by immunohistochemistry in paraffin-embedded glioma tissues from 146 patients.	Paraffin	57-65	polymeric immunoglobulin receptor	Homo sapiens	0-4
12666714-8	2003	The expression of PCNA was evaluated in formalin-fixed, paraffin-embedded gingival samples using an immunoperoxidase technique and PC10 monoclonal antibody to PCNA.	Paraffin	56-64	proliferating cell nuclear antigen	Homo sapiens	18-22
12591966-2	2003	The recently commercially available Hep Par 1 antibody (clone OCH1E5.2.10) has been reported to be a sensitive marker for HCC in paraffin embedded sections.	Paraffin	129-137	Prader Willi/Angelman region RNA 1	Homo sapiens	40-45
32294701-2	2020	DPP4 expression was measured in formalin-fixed paraffin-embedded specimens that were gathered from 327 HCC patients.	Paraffin	47-55	dipeptidyl peptidase 4	Homo sapiens	0-4
12690634-4	2003	Matrilysin expression was immunohistochemically analyzed using formalin-fixed, paraffin-embedded specimens from 113 colorectal cancer patients who had undergone curative surgery.	Paraffin	79-87	matrix metallopeptidase 7	Homo sapiens	0-10
24185120-7	2014	Quantitative expression of p27 using immunostaining was analyzed using paraffin blocks of thyroidectomy specimens in all patients.	Paraffin	71-79	interferon alpha inducible protein 27	Homo sapiens	27-30
31250373-4	2020	STIP1 expression was analyzed in paraffin-embedded bladder cancer tissue samples of 98 patients who underwent adjuvant or salvage cisplatin-based chemotherapy by using immunohistochemistry.	Paraffin	33-41	stress induced phosphoprotein 1	Homo sapiens	0-5
24827824-2	2014	METHODS: ALDH1 immunohistochemistry was performed on formalin-fixed, paraffin wax-embedded cervical tumour tissue samples obtained from hospital archives.	Paraffin	69-81	aldehyde dehydrogenase 1 family member A1	Homo sapiens	9-14
14634507-7	2003	Then we investigated XBP-1 expression by immunohistochemically on archived paraffin-embedded sections.	Paraffin	75-83	X-box binding protein 1	Homo sapiens	21-26
31557339-2	2020	METHODS AND RESULTS: A retrospective review of the Mayo Clinic cytogenetic database identified 470 patients evaluated by FISH testing for TP63 rearrangements in formalin-fixed paraffin-embedded (FFPE) tissue using both BAP and D-FISH probes.	Paraffin	176-184	tumor protein p63	Homo sapiens	138-142
12937847-4	2003	DPP IV/CD 26 was assessed in paraffin-embedded thyroid specimens immunohistochemically using commercially available antibody (Serotec) and biotinylated tyramine amplification kit (DAKO).	Paraffin	29-37	dipeptidyl peptidase 4	Homo sapiens	0-6
12456216-8	2002	Paraffin immunohistochemical studies showed positivity of the tumor cells for CD45, TIA-1, granzyme B, CD56, and CD3 epsilon.	Paraffin	0-8	granzyme B	Homo sapiens	91-101
12456216-8	2002	Paraffin immunohistochemical studies showed positivity of the tumor cells for CD45, TIA-1, granzyme B, CD56, and CD3 epsilon.	Paraffin	0-8	neural cell adhesion molecule 1	Homo sapiens	103-107
12456216-8	2002	Paraffin immunohistochemical studies showed positivity of the tumor cells for CD45, TIA-1, granzyme B, CD56, and CD3 epsilon.	Paraffin	0-8	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	113-124
12658356-5	2002	As a model system, we assessed estrogen receptor (ER) in paraffin sections of mouse ovary.	Paraffin	57-65	estrogen receptor 1 (alpha)	Mus musculus	31-48
12658356-5	2002	As a model system, we assessed estrogen receptor (ER) in paraffin sections of mouse ovary.	Paraffin	57-65	estrogen receptor 1 (alpha)	Mus musculus	50-52
25025378-4	2014	XRCC1 Arg399Glu and ERCC1 Cys8092Ala SNPs were identified from paraffin-embedded biopsy specimens via Sanger sequencing.	Paraffin	63-71	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	20-25
24889502-4	2014	We developed and validated a new real-time quantitative polymerase chain reaction (PCR) assay for single-step detection of IDH1 R132H and 11 rare IDH1/2 mutations in formalin-fixed paraffin-embedded (FFPE) glioma samples.	Paraffin	181-189	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	123-127
24889502-4	2014	We developed and validated a new real-time quantitative polymerase chain reaction (PCR) assay for single-step detection of IDH1 R132H and 11 rare IDH1/2 mutations in formalin-fixed paraffin-embedded (FFPE) glioma samples.	Paraffin	181-189	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	146-152
12658356-6	2002	ER was detected by Southwestern histochemistry in autoclaved or microwaved paraffin sections, and no signal was detected without such pretreatment.	Paraffin	75-83	estrogen receptor 1 (alpha)	Mus musculus	0-2
31609157-2	2019	We used commercial polyclonal and monoclonal antibodies and characterized three chromogenic cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) assays with suitable specificity and sensitivity for use in formalin-fixed, paraffin-embedded (FFPE) tissues.	Paraffin	221-229	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	137-143
12669436-2	2002	METHOD: Using immunohistochemical method SABC, we studied the expression of Fas and FasL protein in 42 cases of paraffin-embedded LSCC tissues and in 10 cases of normal laryngeal tissues.	Paraffin	112-120	Fas ligand	Homo sapiens	84-88
12630556-6	2002	The expression of E-cadherin were examined in four groups of rat colon tissues by immunohistochemistry on paraffin sections.	Paraffin	106-114	cadherin 1	Rattus norvegicus	18-28
24202438-6	2014	Immunohistochemistry for MMP-1 was performed on formalin-fixed and paraffin-embedded sections.	Paraffin	67-75	matrix metallopeptidase 1	Homo sapiens	25-30
31272054-0	2019	The impact of baking on chlorinated paraffins: Characterization of C10-C17 chlorinated paraffins in oven-baked pastry products and unprocessed pastry dough by HPLC-ESI-Q-TOF-MS.	Paraffin	36-45	cytokine like 1	Homo sapiens	71-74
12516633-6	2002	RESULTS: Expression of FasL was found on cells of choriocarcinoma in paraffin sections in situ and on three choriocarcinoma cell lines such as JEG-3, JAR and BeWo.	Paraffin	69-77	Fas ligand	Homo sapiens	23-27
24606013-0	2014	Expression level of miR-93 in formalin-fixed paraffin-embedded tissues of breast cancer patients.	Paraffin	45-53	microRNA 9-3	Homo sapiens	20-26
31272054-0	2019	The impact of baking on chlorinated paraffins: Characterization of C10-C17 chlorinated paraffins in oven-baked pastry products and unprocessed pastry dough by HPLC-ESI-Q-TOF-MS.	Paraffin	87-96	cytokine like 1	Homo sapiens	71-74
24606013-2	2014	The objective of this study was to evaluate the potential predictive value of miR-93 expression in formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer patients.	Paraffin	114-122	microRNA 9-3	Homo sapiens	78-84
31197258-3	2019	Here, the EuroClonality-NGS Working Group presents a multicentre technical feasibility study of a novel approach involving next-generation sequencing (NGS) of IGH and IGK loci rearrangements that is highly suitable for detecting IG gene rearrangements in frozen and formalin-fixed paraffin-embedded tissue specimens.	Paraffin	281-289	immunoglobulin kappa locus	Homo sapiens	167-170
12374666-8	2002	Immunostaining of paraffin-embedded tumor tissue sections in rats showed an overexpression of human EMAP-II.	Paraffin	18-26	aminoacyl tRNA synthetase complex interacting multifunctional protein 1	Homo sapiens	100-107
12170084-1	2002	Hepatocyte monoclonal antibody (Hep) (alternatively Hep Par 1 for Hep paraffin 1) has been reported to stain normal hepatic tissue and hepatocellular carcinoma (HCC) with high specificity.	Paraffin	70-78	Prader Willi/Angelman region RNA 1	Homo sapiens	56-61
31535805-6	2019	In all cases PD-L1 expression in tumor cells was evaluated by immunohistochemical studies of paraffin block sections obtained under direct control of pathologist.	Paraffin	93-101	CD274 molecule	Homo sapiens	13-18
12107263-7	2002	In 132 paraffin-embedded thyroid carcinoma tissue samples, cytoplasmic beta-catenin was immunohistochemically observed in 52 out of 78 (67%) papillary thyroid cancers, but only in 3 of 34 (9%) follicular adenomas and 5 of 20 (25%) follicular cancers.	Paraffin	7-15	catenin beta 1	Homo sapiens	71-83
11854597-2	2002	In this study, the authors describe a new real-time reverse transcriptase-polymerase chain reaction (RT-PCR) method to detect SYT/SSX fusion transcripts using paraffin-embedded and frozen tumor specimens.	Paraffin	159-167	SSX family member 2B	Homo sapiens	130-133
26176052-5	2014	pIgR expression was further confirmed by quantitative real-time PCR in cryopreserved primary colon carcinoma and paired hepatic metastasis tissues from 32 patients with hepatic metastatic colon cancer and by immunohistochemistry in paraffin-embedded primary colon carcinoma and paired hepatic metastasis tissues from 136 patients with liver metastasis from colon carcinoma who underwent hepatic resection.	Paraffin	232-240	polymeric immunoglobulin receptor	Homo sapiens	0-4
24765159-3	2014	A total of 154 paraffin-embedded ccRCC tissues were studied using immunohistochemistry, which subsequently indicated that positive B7-H4 expression is associated with adverse clinical features in ccRCC.	Paraffin	15-23	V-set domain containing T cell activation inhibitor 1	Mus musculus	131-136
31840034-0	2019	Genotyping of the OATP1B1 c. 521 T>C Polymorphism from the Formalin-Fixed Paraffin-Embedded (FFPE) Tissue Specimens: an Optimized Protocol.	Paraffin	74-82	solute carrier organic anion transporter family member 1B1	Homo sapiens	18-25
11990392-4	2002	METHODS: Proliferating cell nuclear antigen was localised by immunoperoxidase on microwave oven pre-treated formalin-fixed, paraffin embedded sections using PC10 monoclonal antibody.	Paraffin	124-132	proliferating cell nuclear antigen	Homo sapiens	9-43
31840034-4	2019	Formalin-fixed paraffin-embedded (FFPE) liver tissues can be an enriched source for genotyping of this clinically significant OATP1B1 polymorphism in retrospective studies.	Paraffin	15-23	solute carrier organic anion transporter family member 1B1	Homo sapiens	126-133
24122631-3	2014	The aim of this study is to investigate if miR-21 expression from RNA isolated from formalin-fixed paraffin-embedded (FFPE) tissue sections is associated with prognosis and therapeutic outcome for patients with CC.	Paraffin	99-107	microRNA 21	Homo sapiens	43-49
31358091-4	2019	METHODOLOGY: Paraffin blocks of diagnosed cases of oral SCC presenting at Pathology Department, KEMU, were selected for immunostain GLUT 1.	Paraffin	13-21	serpin family B member 3	Homo sapiens	56-59
24710941-4	2014	The protein expression level of MUC15 was immunohistochemically detected in paraffin-embedded samples of 317 glioma tissues and 115 noncancerous brain tissues.	Paraffin	76-84	mucin 15, cell surface associated	Homo sapiens	32-37
11944999-1	2002	Inducible nitric oxide synthase (iNOS) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 10 natural cases of porcine pleuropneumonia.	Paraffin	101-113	LOC396821	Sus scrofa	0-31
11944999-1	2002	Inducible nitric oxide synthase (iNOS) protein was detected immunohistochemically in formalin-fixed, paraffin wax-embedded lung tissues from 10 natural cases of porcine pleuropneumonia.	Paraffin	101-113	LOC396821	Sus scrofa	33-37
12181718-9	2002	CONCLUSION: These findings indicate that the efficacy of octreotide may be correlated with the density of sst 2 and 3 in an immunohistological study using paraffin sections.	Paraffin	155-163	sushi, nidogen and EGF like domains 1	Homo sapiens	106-117
32734203-4	2019	His first kidney biopsy showed masked IgG3 deposition, such that IgG3 staining was apparent only after digestion by enzyme on paraffin tissue, with a membranoproliferative pattern.	Paraffin	126-134	immunoglobulin heavy constant gamma 3 (G3m marker)	Homo sapiens	65-69
11598155-5	2001	In the present study, we developed a tissue microdissection approach designed for use with formalin-fixed, paraffin-embedded specimens which is capable of detecting and characterizing the hOGG1 allelic loss using two highly informative, intragenic single nucleotide polymorphisms.	Paraffin	107-115	8-oxoguanine DNA glycosylase	Homo sapiens	188-193
24277378-5	2014	Immunohistochemistry was performed to examine FLOT1 protein expression in paraffin-embedded tissues from 106 NSCLC patients.	Paraffin	74-82	flotillin 1	Homo sapiens	46-51
31360780-3	2019	Here, we immunohistochemically evaluated HER2 expression in 21 paraffin-embedded cTC tissues and scored the degree of expression based on intensity and positivity (score: 0-3+).	Paraffin	63-71	erb-b2 receptor tyrosine kinase 2	Canis lupus familiaris	41-45
24695539-3	2014	Immunohistochemistry was performed to examine FLOT1 protein expression in paraffin-embedded tissues from 181 cN0 TSCC patients.	Paraffin	74-82	flotillin 1	Homo sapiens	46-51
11494227-4	2001	Matrilysin expression was immunohistochemically analyzed using formalin-fixed, paraffin-embedded specimens from 113 colorectal cancer patients who had undergone curative surgery.	Paraffin	79-87	matrix metallopeptidase 7	Homo sapiens	0-10
11561755-1	2001	In order to confirm the presence of SYT-SSX fusion gene in epithelial and spindle cell components of synovial sarcoma, we performed a nested reverse transcriptase-polymerase chain reaction (RT-PCR) using microbeam microdissection of membrane-mounted native tissue (MOMeNT) technique applied on formalin-fixed, paraffin-embedded tumor specimens from two biphasic synovial sarcomas and a control tissue of adamantinoma.	Paraffin	310-318	SSX family member 2B	Homo sapiens	40-43
11394742-6	2001	Exon-specific amplification by polymerase chain reaction and direct DNA sequencing of KVLQT1 revealed a 5-base pair deletion in the genetic material recovered from the decedent"s paraffin-embedded heart tissue.	Paraffin	179-187	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	86-92
24815433-3	2014	The aim of this study was to detect the expression of lncRNA MALAT1 in PDAC formalin-fixed, paraffin embedded (FFPE) tissues and to investigate the clinical significance of the MALAT1 level.	Paraffin	92-100	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	61-67
31371997-1	2019	Purpose: The aim of this study was to compare the expression of miR-21 gene in stages II-IV of formalin-fixed paraffin-embedded (FFPE) tissue in patients with colon cancer and introduce miR-21 as a potential molecular marker for detection of colon cancer in the early stages.	Paraffin	110-118	microRNA 21	Homo sapiens	64-70
24669077-9	2014	Paraffin sections were immunostained with TTF-1 and p-63 and the tumors were subtyped.	Paraffin	0-8	tumor protein p63	Homo sapiens	52-56
24259349-2	2013	HOXA11 hypermethylation was characterized in six lung cancer cell lines, and its clinical significance was analyzed using formalin-fixed paraffin-embedded tissues from 317 NSCLC patients, and Ki-67 expression was analyzed using immunohistochemistry.	Paraffin	137-145	homeobox A11	Homo sapiens	0-6
11386825-1	2001	PC10, a monoclonal antibody (mAb) to proliferating cell nuclear antigen (PCNA) is known to show immunoreactivity in paraffin-embedded specimens.	Paraffin	116-124	proliferating cell nuclear antigen	Homo sapiens	37-71
11386825-1	2001	PC10, a monoclonal antibody (mAb) to proliferating cell nuclear antigen (PCNA) is known to show immunoreactivity in paraffin-embedded specimens.	Paraffin	116-124	proliferating cell nuclear antigen	Homo sapiens	73-77
11386825-3	2001	PCNA scores were obtained by immunohistochemical staining of the paraffin-embedded sections using a streptavidin-biotin immunoperoxidase method with PC10 mAb.	Paraffin	65-73	proliferating cell nuclear antigen	Homo sapiens	0-4
31164357-4	2019	We tested for cytoplasmic- and membrane-associated PCNA by FACS- and ImageStream-based staining of cell lines and IHC of human cancer formalin fixed, paraffin embedded tissues.	Paraffin	150-158	proliferating cell nuclear antigen	Homo sapiens	51-55
11280778-6	2001	The presence of SNAP-25 and syntaxin1 in SCLC was confirmed by RT-PCR performed with material extracted from paraffin sections.	Paraffin	109-117	synaptosome associated protein 25	Homo sapiens	16-23
11172303-0	2001	Detection of the synovial sarcoma translocation t(X;18) (SYT;SSX) in paraffin-embedded tissues using reverse transcriptase-polymerase chain reaction: a reliable and powerful diagnostic tool for pathologists.	Paraffin	69-77	SSX family member 2B	Homo sapiens	61-64
23824915-4	2013	For further validation of this finding, the expression of miR-19a and miR-19b was detected by qRT-PCR and in situ hybridization(ISH) in 8 malignant glioma cell lines, 43 freshly resected glioma samples and 75 archival paraffin embedded glioma specimens with different grades of malignancy in the present study.	Paraffin	218-226	microRNA 19a	Homo sapiens	58-65
30744470-4	2019	SUBJECTS AND METHODS: The abundance of CD169+ cells in the subcapsular sinuses (SCSs) of lymph nodes was assessed immunohistochemically in paraffin-embedded tissue samples derived from 22 patients with oral cavity and oropharyngeal SCC.	Paraffin	139-147	sialic acid binding Ig like lectin 1	Homo sapiens	39-44
23760979-5	2013	In addition, stathmin 1 expression was analyzed by immunohistochemistry in paraffin samples from 210 primary gastric cancer patients.	Paraffin	75-83	stathmin 1	Homo sapiens	13-23
24086281-9	2013	Our studies fully validate this immunohistochemical assay for LKB1 in paraffin-embedded formalin tissue sections.	Paraffin	70-78	serine/threonine kinase 11	Homo sapiens	62-66
11135226-3	2000	METHODS: The authors studied COX-1 and -2 expression in 20 tumors of the lung, colon, and breast (60 total) by using commercially available monoclonal and polyclonal antibodies on formalin fixed, paraffin embedded tissue.	Paraffin	196-204	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	29-41
31110630-8	2019	Immunohistochemistry was used to analyze SOX2, OCT4, caspase-3, Chk1, and hTERT expression in paraffin sections of the initial biopsy.	Paraffin	94-102	telomerase reverse transcriptase	Homo sapiens	74-79
11193470-6	2000	Immunohistochemical expression of beta-catenin was studied in formalin-fixed, paraffin-embedded tissue samples.	Paraffin	78-86	catenin beta 1	Homo sapiens	34-46
24358796-2	2013	METHOD: We detected the different expression level of ubiquitin in paraffin specimens between 19 cases of LSCC associated with cervical lymph node metastasis LSCC(N+) and 20 cases of LSCC not associated with cervical lymph node metastasis LSCC(N-) by immunohistochemical staining combined with stereology image analysis system.	Paraffin	67-75	ubiquitin	Nicotiana tabacum	54-63
30827467-7	2019	Concordance of 100% was observed between droplet digital PCR and sequencing-based orthogonal methods in the detection of TERT mutant DNA in 32 formalin-fixed, paraffin-embedded melanoma tumors.	Paraffin	159-167	telomerase reverse transcriptase	Homo sapiens	121-125
23725446-4	2013	The expression and relationship of Lewis y antigen and integrin alphav, beta3 are assessed in paraffin sections using immunohistochemistry and double-labeling immunofluorescence method.	Paraffin	94-102	eukaryotic translation elongation factor 1 beta 2 pseudogene 2	Homo sapiens	72-77
11008200-3	2000	The c-myc gene copy number was determined by quantitative PCR from genomic DNA of paraffin-embedded tumors.	Paraffin	82-90	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	4-9
10888749-1	2000	Recent studies on paraffin-embedded tissue have shown that the cyclin-dependent kinase inhibitor p27(Kip1) is expressed in normal thyroid cells, whereas it is downregulated in neoplastic cells.	Paraffin	18-26	cyclin dependent kinase inhibitor 1B	Homo sapiens	101-105
10931240-7	2000	N-myc amplification was studied by fluorescence in-situ hybridization using paraffin-embedded sections.	Paraffin	76-84	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
30906321-8	2019	OB-R transcript (in fresh tissues) and proteins (in formalin-fixed and paraffin-embedded specimens) were expressed in all PTC tissues examined, with no significant differences between BRAF-mutated and BRAF-wild-type tumors.	Paraffin	71-79	leptin receptor	Homo sapiens	0-4
10893290-5	2000	For selected cases, the applicability of RT-PCR and immunohistochemistry for hTRT expression analysis was investigated in paraffin-embedded tissues.	Paraffin	122-130	telomerase reverse transcriptase	Homo sapiens	77-81
23242143-6	2013	Our findings indicate that unambiguous immunodetection of LC3 in paraffin-embedded tissue specimens was hampered due to low in situ levels of this protein.	Paraffin	65-73	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	58-61
23725191-9	2013	RESULTS: Overall 40% of patients (62/154) were found to be SLN positive on final (paraffin section) histology, out of which 44 demonstrated macrometastases (&gt;2mm) and 18 micrometastases (&lt;2mm).	Paraffin	82-90	sarcolipin	Homo sapiens	59-62
30684972-4	2019	METHODS: We investigated the expression of RRBP1 protein by immunohistochemistry on paraffin-embedded surgical specimens from one hundred thirty patients with endometrioid-type endometrial carcinoma.	Paraffin	84-92	ribosome binding protein 1	Homo sapiens	43-48
23451142-8	2013	Further immunohistochemical analysis of the paraffin-embedded lung cancer tissues identified strong S100A15 nuclear staining not only in stage IV NSCLC as compared to stage IIIB NSCLC (p = 0.005), but also in patients with stable or progressive disease as compared to those with a partial response (p = 0.032).	Paraffin	44-52	S100 calcium binding protein A7A	Homo sapiens	100-107
10812008-0	2000	H-ras-1 point mutation in malignant peripheral nerve sheath tumors: polymerase chain reaction restriction fragment length polymorphism analysis and direct sequencing from paraffin-embedded tissues.	Paraffin	171-179	HRas proto-oncogene, GTPase	Homo sapiens	0-7
10781686-0	2000	p53 gene deletions in paraffin-preserved lymphoid tumors from irradiated mice.	Paraffin	22-30	transformation related protein 53, pseudogene	Mus musculus	0-3
30771171-2	2019	Here we describe a method, the alpha-synuclein proximity ligation assay (AS-PLA), to detect alpha-synuclein oligomers in paraffin-embedded brain sections.	Paraffin	121-129	synuclein alpha	Homo sapiens	31-46
10781686-1	2000	Experiments were performed to measure deletions in the p53 gene in paraffin-embedded tissues (tumors and control) derived from mice exposed to gamma-rays or neutrons up to 28 years ago.	Paraffin	67-75	transformation related protein 53, pseudogene	Mus musculus	55-58
22167391-3	2012	In this study, IGFBP-3 was detected by immunohistochemistry (IHC) in paraffin-embedded tissues from 110 ESCC patients, of which 110 were from primary cancer sites and 56 from matched adjacent non-malignant sites.	Paraffin	69-77	insulin like growth factor binding protein 3	Homo sapiens	15-22
22528516-3	2012	NDRG2 and CD24 expression in paraffin-embedded specimens gathered from 166 patients with lung adenocarcinoma was detected by immunohistochemical method.	Paraffin	29-37	NDRG family member 2	Homo sapiens	0-5
30771171-2	2019	Here we describe a method, the alpha-synuclein proximity ligation assay (AS-PLA), to detect alpha-synuclein oligomers in paraffin-embedded brain sections.	Paraffin	121-129	synuclein alpha	Homo sapiens	92-107
10834333-1	2000	To study the genetic defect of the human androgen receptor (hAR) gene in the complete androgen insensitivity syndrome (CAIS), we amplified each of the eight exons by PCR in genomic DNA extracted from the paraffin blocks of the resected gonads.	Paraffin	204-212	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	60-63
30655796-0	2019	Use of ANGPTL2 mRNA levels in formalin-fixed paraffin-embedded tissues as a biomarker to diagnose gastric cancer and to evaluate the extent of vascular invasion.	Paraffin	45-53	angiopoietin like 2	Homo sapiens	7-14
10749136-6	2000	In the present study, we developed a monoclonal antibody found to recognize SSX2, SSX3, and SSX4 proteins expressed in formaldehyde-fixed and paraffin-embedded tissues.	Paraffin	142-150	SSX family member 3	Homo sapiens	82-86
23653844-4	2012	Due to high incidence, mortality, and recurrence rates of bladder cancer and the necessity of accurate prediction of malignant behavior of the tumors, we evaluated the prognostic value of Oct4 expression in formalin-fixed paraffin-embedded (FFPE) tissues of bladder cancer.	Paraffin	222-230	POU class 5 homeobox 1	Homo sapiens	188-192
23050799-6	2012	Additionally, the proteins encoded by DEFA 1/3 and DEFA 4 were visualized in paraffin-embedded tissue sections by immunohistochemical staining.	Paraffin	77-85	defensin alpha 1	Homo sapiens	38-46
11214920-0	2000	Detection of PrP(Sc) in subclinical BSE with the paraffin-embedded tissue (PET) blot.	Paraffin	49-57	PRP@	Bos taurus	13-16
30264546-3	2018	In this study, IDO1 expression in tumor cells (T-IDO1) was frequently detected (109/112) by immunohistochemistry in formalin-fixed paraffin-embedded specimens from HCC patients, and the expression patterns were mostly focal (102/109).	Paraffin	131-139	indoleamine 2,3-dioxygenase 1	Homo sapiens	15-19
11100428-5	2000	E-selectin was detected in paraffin sections using the ABC technique and the expression was scored semiquantitatively by evaluating the intensity and incidence of positively stained endothelium of the interstitial pulmonary microvasculature.	Paraffin	27-35	selectin E	Homo sapiens	0-10
10594136-3	2000	The diagnosis was confirmed by demonstration of the characteristic SYT/SSX gene fusion by reverse transcriptase polymerase chain reaction (RT-PCR) performed upon RNA extracted from the paraffin block of the biopsy.	Paraffin	185-193	SSX family member 2B	Homo sapiens	71-74
10974930-2	2000	An immunohistochemical study with a mouse monoclonal antibody against PCNA (Novocastra, Clone PC10, IgG2a Class) was performed on paraffin embedded specimens using the ABComplex/HRP method.	Paraffin	130-138	proliferating cell nuclear antigen	Homo sapiens	70-74
22360629-0	2012	IDH mutation detection in formalin-fixed paraffin-embedded gliomas using multiplex PCR and single-base extension.	Paraffin	41-49	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	0-3
10600295-6	1999	Furthermore, the downregulation of Hsp-27 in choriocarcinoma cells was confirmed both in vitro with cell lines and in vivo with paraffin sections using RT-PCR, Western blot, and immunohistochemical techniques.	Paraffin	128-136	heat shock protein family B (small) member 1	Homo sapiens	35-41
30264546-3	2018	In this study, IDO1 expression in tumor cells (T-IDO1) was frequently detected (109/112) by immunohistochemistry in formalin-fixed paraffin-embedded specimens from HCC patients, and the expression patterns were mostly focal (102/109).	Paraffin	131-139	indoleamine 2,3-dioxygenase 1	Homo sapiens	49-53
22819905-4	2012	METHODOLOGY: TS and cyclin D1 protein expression from 140 patients with UICC stage I and II colorectal cancer was analyzed by immunhistochemistry in paraffin-embedded primary tumour specimens.	Paraffin	149-157	thymidylate synthetase	Homo sapiens	13-15
22445362-6	2012	Expression of mutant IDH1 R132H protein was determined by immunohistochemistry on representative formalin-fixed, paraffin-embedded sections using the antihuman mouse monoclonal antibody IDH1 R132H (Dianova, Hamburg, Germany).	Paraffin	113-121	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	21-25
22851866-1	2012	AIM: To establish methods for quantitative polymerase chain reaction (PCR) for hepcidin using RNAs isolated from paraffin-embedded sections and in situ hybridization of hepatocellular carcinoma (HCC).	Paraffin	113-121	hepcidin antimicrobial peptide	Homo sapiens	79-87
22851866-6	2012	RESULTS: Quantitative PCR for hepcidin using RNAs isolated from paraffin-embedded sections of HCC was performed successfully.	Paraffin	64-72	hepcidin antimicrobial peptide	Homo sapiens	30-38
22169481-9	2012	ERCC1 messenger RNA expression in paraffin-embedded tumor specimens was detected by branched DNA assay.	Paraffin	34-42	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	0-5
22611320-2	2012	METHODS: CD74, MIF and TLR4 expression in the paraffin-embedded sections of gastric cancer from 120 patients were detected by immunohistochemical staining.	Paraffin	46-54	toll like receptor 4	Homo sapiens	23-27
22351685-9	2012	IGKC protein expression was significantly associated with survival in paraffin-embedded tissues of 330 breast cancer patients.	Paraffin	70-78	immunoglobulin kappa constant	Homo sapiens	0-4
22172726-0	2012	Proteome analysis of laser microdissected glomeruli from formalin-fixed paraffin-embedded kidneys of autopsies of diabetic patients: nephronectin is associated with the development of diabetic glomerulosclerosis.	Paraffin	72-80	nephronectin	Homo sapiens	133-145
22781348-2	2012	METHODS: IDH1 was detected in a series of 165 oligodendroglial paraffin specimens from 2009 to 2011.	Paraffin	63-71	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	9-13
22969893-9	2012	MAD2 expression was examined in paraffin-embedded sections using the avidin-biotin peroxidase complex method.	Paraffin	32-40	mitotic arrest deficient 2 like 1	Homo sapiens	0-4
22740895-8	2012	MAD2 expression was examined in paraffin-embedded sections using the avidin-biotin peroxidase complex method.	Paraffin	32-40	mitotic arrest deficient 2 like 1	Homo sapiens	0-4
21909753-2	2012	The clinical gold standard for assessing microvessel density is CD105 immunohistochemistry on paraffin-embedded tumor specimens.	Paraffin	94-102	endoglin	Mus musculus	64-69
22033727-4	2012	METHODS: We investigated the expression of PTEN and phospho-Akt in 146 formalin-fixed (archived) paraffin-embedded oral squamous cell carcinoma tissue sections through immunohistochemical analysis.	Paraffin	97-105	phosphatase and tensin homolog	Homo sapiens	43-47
21391216-0	2012	Profiling signalling pathways in formalin-fixed and paraffin-embedded breast cancer tissues reveals cross-talk between EGFR, HER2, HER3 and uPAR.	Paraffin	52-60	plasminogen activator, urokinase receptor	Homo sapiens	140-144
21815153-2	2012	METHODS: EnVision immunohistochemical method for determining the expressions of MUC1 and MUC5AC was used in routinely paraffin-embedded sections of surgically resected specimens from gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenoma (n = 15), and chronic cholecystitis (n = 35).	Paraffin	118-126	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	89-95
22347464-0	2012	KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.	Paraffin	74-82	anaplastic lymphoma kinase	Mus musculus	5-8
22129926-5	2011	Protein expression in paraffin-embedded specimens of prostates gathered from 300 patients with PCa was detected by immunohistochemistry using a monoclonal antibody against EMMPRIN.	Paraffin	22-30	basigin (Ok blood group)	Homo sapiens	172-179
20022267-5	2011	OPN expression were evaluated by immunohistochemistry staining on paraffin-embedded section of the tumor and scored by two qualified pathologists.	Paraffin	66-74	secreted phosphoprotein 1	Homo sapiens	0-3
21345667-5	2011	METHODS: We performed immunohistochemical analyses on formalin-fixed paraffin embedded (FFPE) cancer tissue with an antibody against the Dicer protein.	Paraffin	69-77	dicer 1, ribonuclease III	Homo sapiens	137-142
21354147-4	2011	METHODS: We used immunohistochemical analyses to examine the expression of mPGES-1 in formalin-fixed, paraffin-embedded human cholangiocarcinoma tissues.	Paraffin	102-110	prostaglandin E synthase	Mus musculus	75-82
21325072-2	2011	EXPERIMENTAL DESIGN: The correlation of SPHK1 expression and clinical features of NSCLC was analyzed in 218 paraffin-embedded archived NSCLC specimens by immunohistochemical analysis.	Paraffin	108-116	sphingosine kinase 1	Homo sapiens	40-45
20605361-4	2011	Three single nucleotide polymorphisms within the matrix metalloproteinase-7 gene were assessed with respect to age at diagnosis, margin status, extracapsular extension, lymph node involvement, recurrence-free survival, and overall survival in paraffin-embedded prostate tissue specimens from patients with early-stage prostate cancer who underwent radical prostatectomy.	Paraffin	243-251	matrix metallopeptidase 7	Homo sapiens	49-75
21426588-4	2011	Immunohistochemistry was used to assess ERCC1 expression in pretreatment biopsy specimens from paraffin blocks.	Paraffin	95-103	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	40-45
20682317-11	2010	CONCLUSIONS: A bisulfite-pyrosequencing assay to measure methylation of the IGF2 DMR0 is robust and applicable to paraffin-embedded tissue.	Paraffin	114-122	insulin like growth factor 2	Homo sapiens	76-80
19936974-4	2010	The expression patterns of mTOR and p70S6K in paraffin-embedded specimens gathered from 65 patients with primary osteosarcoma were detected by the method of immunohistochemistry using antibodies against mTOR and p70S6K.	Paraffin	46-54	ribosomal protein S6 kinase B1	Homo sapiens	36-42
20606369-1	2010	An alkaline-based chemical antigen retrieval pretreatment step was used to enhance immunolabeling of disease-associated prion protein (PrP(Sc)) in formalin-fixed and paraffin-embedded tissue sections from cattle naturally affected with bovine spongiform encephalopathy (BSE).	Paraffin	166-174	PRP@	Bos taurus	135-138
20807921-0	2010	Detection of PrP(Sc) in formalin-fixed, paraffin-embedded tissue by Western blot differentiates classical scrapie, Nor98 scrapie, and bovine spongiform encephalopathy.	Paraffin	40-48	PRP@	Bos taurus	13-16
20807921-7	2010	Recently, a WB method using formalin-fixed, paraffin-embedded (FFPE) tissue to identify PrP(Sc) was developed that successfully identified PrP(Sc) in sheep affected by classical scrapie.	Paraffin	44-52	major prion protein	Ovis aries	88-91
20807921-7	2010	Recently, a WB method using formalin-fixed, paraffin-embedded (FFPE) tissue to identify PrP(Sc) was developed that successfully identified PrP(Sc) in sheep affected by classical scrapie.	Paraffin	44-52	major prion protein	Ovis aries	139-142
20635438-6	2010	Immunohistochemistry with an anti-cathepsin E antibody was performed on slides of hippocampus obtained from whole brain paraffin blocks.	Paraffin	120-128	cathepsin E	Rattus norvegicus	34-45
20664024-0	2010	Quantitation of p95HER2 in paraffin sections by using a p95-specific antibody and correlation with outcome in a cohort of trastuzumab-treated breast cancer patients.	Paraffin	27-35	nibrin	Homo sapiens	16-19
20013612-4	2010	Paraffin sections of thyroid specimens obtained from 59 papillary thyroid carcinoma consecutive patients were stained using antibody to FasL.	Paraffin	0-8	Fas ligand	Homo sapiens	136-140
21122411-2	2010	METHODS: EnVision(TM) immunohistochemical staining was used to detect the expression of ANXA1 and ANXA2 in paraffin-embedded tissue sections from resected specimens of adenocarcinoma (n = 108), peritumoral tissue (n = 46), adenomatous polyp (n = 15) and chronic cholecystitis (n = 35).	Paraffin	107-115	annexin A2	Homo sapiens	98-103
20431032-3	2010	The aim of this study was to develop and evaluate the performance of a novel real-time PCR and post-PCR fluorescence melting curve analysis assay for the detection of IDH1 and IDH2 mutations in routine formalin-fixed, paraffin-embedded tissues of brain biopsies.	Paraffin	218-226	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	167-171
20431032-9	2010	In summary, we report here the real-time PCR/fluorescence melting curve analysis assay that provides rapid and sensitive detection of IDH mutations in formalin-fixed, paraffin-embedded tissues, and is therefore useful as a powerful adjunct diagnostic tool for refining histopathological diagnosis of brain lesions and guiding patient management.	Paraffin	167-175	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	134-137
20412119-3	2010	Here, we detected Rab5a in paraffin-embedded samples of 20 ovarian cysts, 20 benign cystadenomas, and 39 ovarian cancers by immunohistochemistry, and observed that Rab5a expression was significantly higher in ovarian cancer (P = 0.0001).	Paraffin	27-35	RAB5A, member RAS oncogene family	Homo sapiens	18-23
20491588-2	2010	The mRNA and protein expression levels of Wnt1/beta-catenin genes in 70 ESCC and 15 adjacent noncancerous paraffin-embedded samples were determined by real-time quantitative polymerase chain reaction and immunohistochemical staining.	Paraffin	106-114	catenin beta 1	Homo sapiens	47-59
19863700-2	2010	We investigated the expression of C3d in formalin-fixed, paraffin-embedded tissue of autoimmune bullous dermatoses.	Paraffin	57-65	endogenous retrovirus group K member 13	Homo sapiens	34-37
20035116-2	2010	In Experiment I, the multiplicity of hepatocellular foci in paraffin-embedded sections which were observed in HE-stained sections and positive for CK8/18 was 10.17 and 18.50, respectively, while that of hepatocellular foci in frozen sections which were observed in HE-stained sections and positive/negative for GGT was 6.17 and 8.17, respectively.	Paraffin	60-68	keratin 8	Mus musculus	147-150
20035116-3	2010	In Experiment II, the total multiplicity of hepatocellular foci in paraffin-embedded sections which were observed in HE-stained sections and positive/negative for CK8/18 was 4.47 and 23.17, respectively, while that of hepatocellular foci in frozen sections which were observed in HE-stained sections and positive/negative for GGT was 2.50 and 3.50, respectively.	Paraffin	67-75	keratin 8	Mus musculus	163-166
20335127-2	2010	METHODS: Immunohistochemical EnVison method was used to detect the expressions of ER, VIM, CEA and p16 in paraffin-embedded tissues from 31 cases of primary endocervical adenocarcinomas and 30 cases of endometrial adenocarcinomas.	Paraffin	106-114	vimentin	Homo sapiens	86-89
20126411-4	2010	METHODS AND FINDINGS: Using archival formalin-fixed paraffin embedded (FFPE) extracted genomic DNA, we show that c-CBL mutations occur in somatic fashion for lung cancers.	Paraffin	52-60	Cbl proto-oncogene	Homo sapiens	113-118
20080488-3	2010	Here, RAD51 protein expression was analyzed by immunohistochemistry in paraffin-embedded mammary carcinomas and their lymph node metastases of 40 dogs, adenomas of 48 dogs, and nonneoplastic mammary gland of 88 dogs.	Paraffin	71-79	RAD51 recombinase	Canis lupus familiaris	6-11
20130358-2	2010	METHODS: The distribution of GPRC6A mRNA in paraffin embedded adult mouse tissues was determined by highly sensitive nonradioactive cRNA probe in situ hybridization (ISH).	Paraffin	44-52	G protein-coupled receptor, family C, group 6, member A	Mus musculus	29-35
19661148-5	2009	Signaling transducers phosphorylated SMAD2/3, and signaling modulators SMAD6, MAN-1, inhibin alpha (INHA), and beta-glycan were detected in Bouins fixed, paraffin-embedded adult human testis sections using immunohistochemistry.	Paraffin	154-162	SMAD family member 6	Homo sapiens	71-76
19683742-4	2009	MATERIAL AND METHODS: Tissue factor expression detected by immunohistochemistry was assessed in 41 formalin fixed, paraffin embedded Wilms tumor cases treated at university hospitals.	Paraffin	115-123	coagulation factor III, tissue factor	Homo sapiens	22-35
19750576-2	2009	METHODS: Immunohistochemical methods were used to detect the expression of TS and GST-pi in surgically resected formalin-fixed, paraffin-embedded esophageal squamous cell carcinoma (ESCC) tissue sections from 102 patients (median age, 58 years) and in 28 normal esophageal mucosa (NEM) samples.	Paraffin	128-136	thymidylate synthetase	Homo sapiens	75-77
19685571-9	2009	RESULTS: We showed that keratin 10 and 15 can be stained on both frozen and paraffin-embedded sections.	Paraffin	76-84	keratin 10	Homo sapiens	24-34
19048397-4	2009	CD147 protein expression in paraffin-embedded specimens gathered from 62 cases of PCa and 30 cases of benign prostatic hyperplasia (BPH) were detected by the method of immunohistochemistry.	Paraffin	28-36	basigin (Ok blood group)	Homo sapiens	0-5
19694826-7	2009	The frequency of rearranged TCRB, TCRG and TCRD genes in six cases with available paraffin-embedded tissue was 100%, 83% and 33%, respectively.	Paraffin	82-90	T cell receptor beta constant 1	Homo sapiens	28-32
19340614-3	2009	DESIGN AND METHOD: The expression of PGRMC1 in breast cancer was verified by immune fluorescent analysis of paraffin sections.	Paraffin	108-116	progesterone receptor membrane component 1	Homo sapiens	37-43
19442604-8	2009	Immunohistochemistry confirmed the presence of MMP-1 and MMP-13 in paraffin-embedded GCT tissue samples.	Paraffin	67-75	matrix metallopeptidase 1	Homo sapiens	47-52
19360339-12	2009	The prognostic significance of hTERT expression demonstrated on paraffin sections from different tumor localizations was not confirmed for the frozen sections of patients with HNSCC.	Paraffin	64-72	telomerase reverse transcriptase	Homo sapiens	31-36
19276261-8	2009	In situ hybridization for microRNA-21 showed strong positive staining in paraffin-embedded esophageal squamous cell carcinoma tissues.	Paraffin	73-81	microRNA 21	Homo sapiens	26-37
10578995-11	1999	Immunocytochemical staining revealed a positive reaction in the cytoplasm of tumor cells for vimentin and desmin in the FNA smear and paraffin section, respectively.	Paraffin	134-142	vimentin	Homo sapiens	93-101
10578995-11	1999	Immunocytochemical staining revealed a positive reaction in the cytoplasm of tumor cells for vimentin and desmin in the FNA smear and paraffin section, respectively.	Paraffin	134-142	desmin	Homo sapiens	106-112
10483782-6	1999	Double-labelling experiments performed on paraffin sections with phosphorylation-dependent anti-tau antibody AT8, anti-glial fibrillary acidic protein and anti-CD44, revealed coexpression of these markers in stellate cells.	Paraffin	42-50	microtubule associated protein tau	Homo sapiens	96-99
10485474-0	1999	Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage.	Paraffin	27-35	phosphatase and tensin homolog	Homo sapiens	8-12
10428315-2	1999	DESIGN: In situ hybridization for H19 RNA using S-labeled and digoxigenin-labeled probes was performed on paraffin sections of ovarian surface epithelial tumors.	Paraffin	106-114	H19 imprinted maternally expressed transcript	Homo sapiens	34-37
10373663-9	1999	PCNA immunostaining can be applied on a routine basis in formalin-fixed, paraffin-embedded samples of NSCLC to predict patient prognosis and thus to identify patients in need of additional postoperative therapies.	Paraffin	73-81	proliferating cell nuclear antigen	Homo sapiens	0-4
10094414-6	1999	NF-H coexists with vimentin-type filaments as seen by dual staining and staining of consecutive serial sections of material embedded in paraffin.	Paraffin	136-144	neurofilament heavy chain	Homo sapiens	0-4
10094414-6	1999	NF-H coexists with vimentin-type filaments as seen by dual staining and staining of consecutive serial sections of material embedded in paraffin.	Paraffin	136-144	vimentin	Homo sapiens	19-27
10461064-4	1999	c-myc amplification in tumor tissue was determined using a differential polymerase chain reaction, a useful procedure for the evaluation of gene amplification in archival formalin-fixed paraffin-embedded tissues, in comparison with a dopamine D2 receptor gene.	Paraffin	186-194	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	0-5
10049521-3	1998	IL-1alpha upregulates IL-6 production; therefore, the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin-embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens, a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity (P=0.32 by Fisher"s exact test).	Paraffin	131-139	interleukin 1 alpha	Homo sapiens	0-9
10049521-3	1998	IL-1alpha upregulates IL-6 production; therefore, the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin-embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens, a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity (P=0.32 by Fisher"s exact test).	Paraffin	250-258	interleukin 1 alpha	Homo sapiens	0-9
10049521-3	1998	IL-1alpha upregulates IL-6 production; therefore, the correlation between IL-1alpha and IL-6 immunoreactivity and OR-positivity in paraffin-embedded human breast tumours was further investigated.The results indicate IL-6 immunoreactivity in 40 of 66 paraffin embedded breast tumour specimens, a finding which did not correlate with the clinical evaluation of oestrogen receptor positivity (P=0.32 by Fisher"s exact test).	Paraffin	250-258	interleukin 1 alpha	Homo sapiens	74-83
9799997-2	1998	There was used immunohistochemical method to evaluate the PCNA score of positive cells in paraffin embedded tissues of laryngeal carcinoma obtained from 90 patients.	Paraffin	90-98	proliferating cell nuclear antigen	Homo sapiens	58-62
9743287-8	1998	Interestingly, perfect matching was observed between stathmin mRNA overexpression, protein overexpression and strong staining for stathmin on paraffin-embedded tumour sections when specimens were available.	Paraffin	142-150	stathmin 1	Homo sapiens	130-138
9796260-1	1998	In a case histologically proven prostatic ductal adenocarcinoma with endometrioid features associated with rectal invasion and multiple liver metastases the expression of prostate specific antigen (PSA) and carcinoembryonic antigen (CEA) was studied immunohistochemically on paraffin sections to clarify markedly elevated PSA and relatively elevated CEA in sera.	Paraffin	275-283	kallikrein related peptidase 3	Homo sapiens	198-201
9764350-4	1998	METHOD OF STUDY: FasL expression in paraffin sections was detected using specific antibodies and confirmed with reverse transcriptase-polymerase chain reaction of total RNA from frozen placentas.	Paraffin	36-44	Fas ligand	Homo sapiens	17-21
9678509-0	1998	PMP-22 gene duplications and deletions identified in archival, paraffin-embedded sural nerve biopsy specimens: correlation to structural changes.	Paraffin	63-71	peripheral myelin protein 22	Homo sapiens	0-6
9678509-5	1998	It is shown for the first time that archival, formalin-fixed, paraffin-embedded sural nerve biopsy samples can be used for establishing the diagnosis of PMP-22 diseases, i.e., HMSN Ia and HNPP, by PCR amplification of the region coding for the PMP-22 gene.	Paraffin	62-70	peripheral myelin protein 22	Homo sapiens	153-159
9678509-5	1998	It is shown for the first time that archival, formalin-fixed, paraffin-embedded sural nerve biopsy samples can be used for establishing the diagnosis of PMP-22 diseases, i.e., HMSN Ia and HNPP, by PCR amplification of the region coding for the PMP-22 gene.	Paraffin	62-70	peripheral myelin protein 22	Homo sapiens	244-250
9687974-3	1998	MATERIALS AND METHODS: By modifying the technique of the "enriched" polymerase chain reaction (PCR), it was possible to detect point mutations at codon 12 of the K-ras oncogene from 25-year-old paraffin-embedded normal lungs and lung adenocarcinomas from mice exposed to radiation.	Paraffin	194-202	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	162-167
9705180-9	1998	The method could be used to demonstrate co-expression of two independent antigens in the same cells, such as PCNA and keratin in carcinoma cells in paraffin sections and for EBNA2 and LMP1 EBV proteins in immunofluorescence preparations of B95-8 cells.	Paraffin	148-156	proliferating cell nuclear antigen	Homo sapiens	109-113
9620029-1	1998	We studied 109 thymic tumors and 423 other neoplasms for immunocytochemical expression of CD5 in paraffin-embedded tissue using 2 monoclonal antibodies.	Paraffin	97-105	CD5 molecule	Bos taurus	90-93
9585007-9	1998	A digoxigenin-labeled detection system for IGF-II is more capable of detecting the cellular expression pattern of IGF-II than radioactive probes and is suitable for analysis of routinely prepared paraffin-embedded material.	Paraffin	196-204	insulin like growth factor 2	Homo sapiens	43-49
9539247-5	1998	METHODS: Ret protein expression was evaluated immunohistochemically in formalin-fixed, paraffin-embedded whole-prostate sections.	Paraffin	87-95	ret proto-oncogene	Homo sapiens	9-12
9475088-4	1998	Linkage to PKD1 was obtained by the analysis of DNA from relatives in three generations and from paraffin blocks and formalin fixed fetal tissues.	Paraffin	97-105	polycystin 1, transient receptor potential channel interacting	Homo sapiens	11-15
9466735-2	1998	In the present study, immunoglobulin heavy chain (IgH) and T-cell receptor (TCR) gene rearrangements were examined by the polymerase chain reaction (PCR) in formalin-fixed and paraffin-embedded specimens obtained from 18 patients; the advantages of this method were evaluated.	Paraffin	176-184	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	76-79
9384449-0	1997	Immunohistochemical detection of CD5 with monoclonal antibody 4C7 on paraffin sections.	Paraffin	69-77	CD5 molecule	Homo sapiens	33-36
9384449-2	1997	Therefore, we tested the utility of monoclonal antibody (MAb) 4C7 to detect CD5 on paraffin sections of 22 cases with low-grade B-cell lymphomas and 4 cases with high-grade B-cell lymphomas and compared the results with CD5 detection by analysis of fresh tissue with a fluorescent-activated cell sorting (FACS).	Paraffin	83-91	CD5 molecule	Homo sapiens	76-79
9384449-3	1997	After heat-induced epitope retrieval we could detect CD5 on paraffin sections in all MCLs and B-CLLs/SLLs, identical to the results of flow cytometry.	Paraffin	60-68	CD5 molecule	Homo sapiens	53-56
9384449-6	1997	We conclude that MAb 4C7 against CD5 is a useful paraffin-reactive marker, especially to correctly identify MCLs on paraffin sections.	Paraffin	49-57	CD5 molecule	Homo sapiens	33-36
9384449-6	1997	We conclude that MAb 4C7 against CD5 is a useful paraffin-reactive marker, especially to correctly identify MCLs on paraffin sections.	Paraffin	116-124	CD5 molecule	Homo sapiens	33-36
9447381-6	1997	CONCLUSIONS: Its reproducible and highly sensitive staining characteristics make RCK108 a useful antibody to be applied as a broad epithelial marker for carcinoma detection in routinely processed paraffin sections.	Paraffin	196-204	mitogen-activated protein kinase kinase kinase 19	Homo sapiens	81-84
9416693-0	1997	Utility of 123C3 monoclonal antibody against CD56 (NCAM) for the diagnosis of small cell carcinomas on paraffin sections.	Paraffin	103-111	neural cell adhesion molecule 1	Homo sapiens	45-49
9416693-0	1997	Utility of 123C3 monoclonal antibody against CD56 (NCAM) for the diagnosis of small cell carcinomas on paraffin sections.	Paraffin	103-111	neural cell adhesion molecule 1	Homo sapiens	51-55
9418731-5	1997	The mitotic TM cells were demonstrated immunocytochemically, using anti-PCNA in paraffin sections of the explants; and the total number of TM cells was determined after paraffin sections were counterstained by hematoxylin.	Paraffin	80-88	proliferating cell nuclear antigen	Homo sapiens	72-76
16728193-1	1997	Monoclonal antibodies to human estrogen receptor were used with an indirect immunohistochemical technique to localize in formalin-fixed, paraffin-embedded sections of the genital tract of the bitch.	Paraffin	137-145	estrogen receptor 1	Canis lupus familiaris	31-48
9269787-1	1997	We describe two new monoclonal antibodies specific for the Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) that are suitable for the immunohistochemical analysis of routinely processed paraffin sections.	Paraffin	205-213	LMP2A	Human gammaherpesvirus 4	92-118
9269787-1	1997	We describe two new monoclonal antibodies specific for the Epstein-Barr virus (EBV)-encoded latent membrane protein 2A (LMP2A) that are suitable for the immunohistochemical analysis of routinely processed paraffin sections.	Paraffin	205-213	LMP2A	Human gammaherpesvirus 4	120-125
9255257-2	1997	In this study, the usefulness of a paraffin section-reactive CD5 antibody (clone CD5/54/B4) for supporting the thymic origin of an epithelial neoplasm was evaluated.	Paraffin	35-43	CD5 molecule	Homo sapiens	61-64
9255257-2	1997	In this study, the usefulness of a paraffin section-reactive CD5 antibody (clone CD5/54/B4) for supporting the thymic origin of an epithelial neoplasm was evaluated.	Paraffin	35-43	CD5 molecule	Homo sapiens	81-84
9263844-3	1997	The growth fraction was evaluated in 92 canine NHLs, previously classified according to the Kiel classification (as adapted to the canine species), by determining the expression of the Ki-67 antigen with the MIB1 antibody on (1) paraffin-wax tissue sections in all 92 cases, and (2) fine-needle aspirates or tumour imprints in 30 cases.	Paraffin	229-237	MIB E3 ubiquitin protein ligase 1	Canis lupus familiaris	208-212
9594301-2	1997	METHODS: PCNA immunoreactivity on paraffin-embedded tissues was assessed retrospectively in 35 cases using labelled streptaridin biotin (LSAB) procedure, and its association with clinical and other biological features was studied.	Paraffin	34-42	proliferating cell nuclear antigen	Homo sapiens	9-13
9208332-4	1997	In situ hybridization assays using digoxigenin-labeled riboprobes for the detection of EF-1 alpha mRNA in routinely formalin-fixed, paraffin-embedded tissue sections showed that EF-1 alpha is a suitable positive control in all types of cells.	Paraffin	132-140	eukaryotic translation elongation factor 1 alpha 2	Homo sapiens	87-97
9164203-3	1997	TS expression was assessed using the immunohistochemical method with the monoclonal antibody TS 106 on paraffin-embedded tissue specimens.	Paraffin	103-111	thymidylate synthetase	Homo sapiens	0-2
9185221-4	1997	Neuropeptide Y and PGP9.5 have the advantage that they can be used in paraffin-embedded material.	Paraffin	70-78	neuropeptide Y	Homo sapiens	0-14
9185221-4	1997	Neuropeptide Y and PGP9.5 have the advantage that they can be used in paraffin-embedded material.	Paraffin	70-78	ubiquitin C-terminal hydrolase L1	Homo sapiens	19-25
9028732-8	1997	Trk receptors were detected in paraffin-embedded tumor tissue sections by means of a pan-Trk polyclonal antibody raised against the 14 carboxy-terminal residues of gp140trk, and trk A, B, and C transcripts were specifically detected by polymerase chain reaction-based amplification on cDNAs derived from tumor RNA with MuLV reverse transcriptase.	Paraffin	31-39	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	0-3
9028733-5	1997	We examined the expression of H19 in the endometrium and ovary during the menstrual cycle by in situ hybridization applied to paraffin sections of human endometrium and ovaries at different stages of differentiation.	Paraffin	126-134	H19 imprinted maternally expressed transcript	Homo sapiens	30-33
9208812-8	1997	METHODS: Using in situ hybridisation with a [35S] labelled probe, H19 mRNA was detected in paraffin wax sections of fetal tissues from the first and second trimesters of pregnancy and of a large array of human adult and childhood tumours arising from these tissues.	Paraffin	91-103	H19 imprinted maternally expressed transcript	Homo sapiens	66-69
9101414-0	1997	Immunocytochemical detection of MART-1 in fresh and paraffin-embedded malignant melanomas.	Paraffin	52-60	retrotransposon Gag like 1	Homo sapiens	32-38
9101414-9	1997	In 13 (25%) of 53 tumors, MART-1 immunoreactivity was more intense in the cytospins, although the differences were marked in only two cases: Microwave-based antigen retrieval renders paraffin-embedded tissues nearly as sensitive as fresh material for use in the immunocytochemical detection of MART-1.	Paraffin	183-191	retrotransposon Gag like 1	Homo sapiens	26-32
9038004-16	1996	In the case of PCNA immunostaining on paraformaldehyde-fixed paraffin-embedded sections, heating at 90 degrees C for at least 3 min was required, however, as the heating condition became more severe, non-specific background stains also increased (Table 6), which is one of the most serious problems in antigen retrieval (Fig.	Paraffin	61-69	proliferating cell nuclear antigen	Homo sapiens	15-19
8841519-6	1996	The increase in ODC activity in the thymus, as well as the reduced ODC activity in the testes and kidney, can be obtained with paraffin.	Paraffin	127-135	ornithine decarboxylase 1	Rattus norvegicus	16-19
8841519-6	1996	The increase in ODC activity in the thymus, as well as the reduced ODC activity in the testes and kidney, can be obtained with paraffin.	Paraffin	127-135	ornithine decarboxylase 1	Rattus norvegicus	67-70
8816581-0	1996	Immunophenotypic analysis of CD5 positivity in paraffin-embedded tissues.	Paraffin	47-55	CD5 molecule	Homo sapiens	29-32
8872149-1	1996	The aim of this study was to evaluate the utility of a new commercially available antibody to thrombomodulin as an endothelial marker in formalin-fixed paraffin-embedded tissue.	Paraffin	152-160	thrombomodulin	Homo sapiens	94-108
8612656-6	1996	Immunohistochemical staining of PCNA was performed using a monoclonal antibody for PC10 on paraffin-embedded specimens.	Paraffin	91-99	proliferating cell nuclear antigen	Homo sapiens	32-36
8634790-2	1996	This study analyzes PCNA expression in 24 cases of primary non-small cell lung cancer using monoclonal PC-10 antibodies in paraffin embedded material.	Paraffin	123-131	proliferating cell nuclear antigen	Homo sapiens	20-24
8554110-0	1996	Utility of a paraffin section-reactive CD56 antibody (123C3) for characterization and diagnosis of lymphomas.	Paraffin	13-21	neural cell adhesion molecule 1	Homo sapiens	39-43
8554110-3	1996	In this study, we evaluated the sensitivity and specificity of a CD56 antibody, 123C3, when applied on routine formalin-fixed, paraffin-embedded tissues for analysis of lymphomas, by comparing the staining results with those obtained on frozen tissues using the CD56 antibody NKH1.	Paraffin	127-135	neural cell adhesion molecule 1	Homo sapiens	65-69
8554110-8	1996	We conclude that with suitable antigen retrieval procedures, 123C3 can be reliably applied on routine paraffin sections for detection of CD56 expression in lymphomas.	Paraffin	102-110	neural cell adhesion molecule 1	Homo sapiens	137-141
8932424-5	1996	In the present study the expression of PCNA was investigated in formalin-fixed, paraffin-embedded biopsy specimens of cholesteatomas and normal skin.	Paraffin	80-88	proliferating cell nuclear antigen	Homo sapiens	39-43
9097708-2	1996	We analyzed the expression of proliferating cell nuclear antigen (PCNA) in ectocervical sections fixed in formalin and embedded in paraffin using monoclonal antibody PC10, PAP and APAAP methods.	Paraffin	131-139	proliferating cell nuclear antigen	Homo sapiens	30-64
9097708-2	1996	We analyzed the expression of proliferating cell nuclear antigen (PCNA) in ectocervical sections fixed in formalin and embedded in paraffin using monoclonal antibody PC10, PAP and APAAP methods.	Paraffin	131-139	proliferating cell nuclear antigen	Homo sapiens	66-70
9097710-3	1996	The PCNA index (the percentage of PCNA positive nuclei) was examined immunohistochemically using monoclonal PC10 antibody on paraffin sections.	Paraffin	125-133	proliferating cell nuclear antigen	Homo sapiens	4-8
7543912-6	1995	In some cases, paraffin embedding revealed antigenic sites that had been formerly masked (e.g., Olympus gp120 and p24A; formaldehyde and glutaraldehyde fixation).	Paraffin	15-23	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	104-109
7473268-1	1995	Proliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S phase of the cell cycle which can be detected immunohistochemically in paraffin-embedded tissue as a useful marker for the proliferating fraction of cells in tissue specimens.	Paraffin	167-175	proliferating cell nuclear antigen	Homo sapiens	0-34
7473268-1	1995	Proliferating cell nuclear antigen (PCNA) is a nuclear protein synthesized in the late G1 and S phase of the cell cycle which can be detected immunohistochemically in paraffin-embedded tissue as a useful marker for the proliferating fraction of cells in tissue specimens.	Paraffin	167-175	proliferating cell nuclear antigen	Homo sapiens	36-40
8545595-3	1995	The expression of PCNA was studied by immunohistochemistry in 70 formalin-fixed, paraffin-embedded specimens of surgically removed adenocarcinomas of the gallbladder.	Paraffin	81-89	proliferating cell nuclear antigen	Homo sapiens	18-22
7558018-6	1995	Immunohistochemical staining of paraffin-embedded sections of the cochlea showed that OCP-II is localized abundantly in nonsensory cells in the organ of Corti; in addition, it was also detected, at a lower concentration, in vestibular sensory organs, as well as auditory and vestibular brain stem nuclei.	Paraffin	32-40	S-phase kinase-associated protein 1	Mus musculus	86-92
7611785-2	1995	Using the avidin-biotin peroxidase complex method, the expression of c-myc protein was examined immunohistochemically for formalin-fixed paraffin embedded tissue of 51 gastric adenocarcinomas including the same cases for c-myc DNA analysis.	Paraffin	137-145	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	69-74
8907001-3	1995	A monoclonal antibody (MoAb) against PCNA is now available and it can react with paraffin-embedded specimens.	Paraffin	81-89	proliferating cell nuclear antigen	Homo sapiens	37-41
7528242-2	1995	Previous studies of paraffin-embedded human skin using antibody to murine MGF and reverse transcription-polymerase chain reaction have demonstrated MGF protein and mRNA expression in keratinocytes and isolated dermal cells.	Paraffin	20-28	kit ligand	Mus musculus	148-151
8592170-2	1995	Expression of NCAM in human pituitary adenomas was assessed on snap-frozen and Bouin"s and/or formalin-fixed, paraffin-embedded archival tissue using a sensitive alkaline phosphatase-antialkaline phosphatase method of immunostaining with the monoclonal antibody, NKH-1.	Paraffin	110-118	neural cell adhesion molecule 1	Homo sapiens	14-18
8685626-12	1995	The proliferating cell nuclear antigen (PCNA) as an auxillary protein for DNA polymerase gamma is an evolutionarily conserved molecule that may be detected in human and animal frozen or paraffin-embedded tissues.	Paraffin	186-194	proliferating cell nuclear antigen	Homo sapiens	4-38
19462894-2	2009	METHODS: The expression of Maspin, VEGF, heparanase gene was detected by immunohistochemistry in formalin-fixed, paraffin-embedded specimens of normal ovaries (n=31) and epithelial ovarian cancers (n=35).	Paraffin	113-121	serpin family B member 5	Homo sapiens	27-33
19007975-3	2009	MATERIALS AND METHODS: Immunohistochemical analysis of PTEN expression was performed in 40 OCCA paraffin-embedded tissues.	Paraffin	96-104	phosphatase and tensin homolog	Homo sapiens	55-59
8685626-12	1995	The proliferating cell nuclear antigen (PCNA) as an auxillary protein for DNA polymerase gamma is an evolutionarily conserved molecule that may be detected in human and animal frozen or paraffin-embedded tissues.	Paraffin	186-194	proliferating cell nuclear antigen	Homo sapiens	40-44
18486530-3	2009	beta-Catenin accumulation was examined by immunohistochemistry in formalin-fixed, paraffin-embedded samples of six ameloblastomas and eight OCs.	Paraffin	82-90	catenin beta 1	Homo sapiens	0-12
29938855-2	2018	PD-L1 IHC assays have been clinically validated only on formalin-fixed paraffin-embedded tissue; however, lung cancer is frequently diagnosed on cytology.	Paraffin	71-79	CD274 molecule	Homo sapiens	0-5
7640465-1	1995	Immunostaining of the proliferating cell nuclear antigen (PCNA) provides important information about cell kinetics and is easily performed on routinely obtained formalin-fixed, paraffin-embedded materials.	Paraffin	177-185	proliferating cell nuclear antigen	Homo sapiens	22-56
7640465-1	1995	Immunostaining of the proliferating cell nuclear antigen (PCNA) provides important information about cell kinetics and is easily performed on routinely obtained formalin-fixed, paraffin-embedded materials.	Paraffin	177-185	proliferating cell nuclear antigen	Homo sapiens	58-62
18942707-1	2009	90K (Mac-2 BP) expression was evaluated by immunohistochemistry in paraffin-embedded tissue from a consecutive series of lymph-node negative breast cancer patients who did not receive adjuvant systemic treatment.	Paraffin	67-75	galectin 3 binding protein	Homo sapiens	0-3
30242969-5	2018	Quantitative real-time polymerase chain reaction-based validation in an independent clinical cohort (n = 88) of formalin-fixed paraffin-embedded clinical GC samples showed that MRC-derived high-risk patients succumb to significantly poor recurrence-free survival in GC patients (P &lt; 0.0001).	Paraffin	127-135	CD200 molecule	Homo sapiens	177-180
18942707-1	2009	90K (Mac-2 BP) expression was evaluated by immunohistochemistry in paraffin-embedded tissue from a consecutive series of lymph-node negative breast cancer patients who did not receive adjuvant systemic treatment.	Paraffin	67-75	galectin 3 binding protein	Homo sapiens	5-13
7496600-9	1995	We conclude that the scores for PCNA and Ki67 antigen, immunohistochemically detected in ethanol fixed, paraffin embedded tissue reflect functional proliferative activity.	Paraffin	104-112	proliferating cell nuclear antigen	Homo sapiens	32-36
7703303-3	1994	Our study showed that PCNA can be identified in routinely processed, paraffin embedded specimens of these fishes.	Paraffin	69-77	proliferating cell nuclear antigen	Homo sapiens	22-26
19818222-2	2009	Because expression of the GD3 ganglioside may have an impact on the melanoma malignancy, and therefore on the patient prognosis, we evaluated the feasibility of a retrospective immunohistochemical study of GD3 in paraffin embedded biopsies of primary melanomas.	Paraffin	213-221	GRDX	Homo sapiens	206-209
30213873-9	2018	We revealed that low levels of miR-150 and high levels of its target, FOXP1, are associated with shorter overall survival in FL and suggest that miR-150 could serve as a good biomarker measurable in formalin-fixed paraffin-embedded tissue.	Paraffin	214-222	forkhead box P1	Homo sapiens	70-75
19404921-3	2009	MATERIALS AND METHODS: Expression of cytokeratin and vimentin was evaluated by immunohistochemistry on paraffin-embedded tissue sections of patients with breast cancer.	Paraffin	103-111	vimentin	Homo sapiens	53-61
7525424-4	1994	Immunohistochemical detection of PCNA/cyclin was performed on paraffin sections by the avidin-extravidin method using the monoclonal antibody PC10 (DAKO).	Paraffin	62-70	proliferating cell nuclear antigen	Homo sapiens	33-44
7838839-0	1994	Immunocytochemical detection of cyclin A and cyclin D in formalin-fixed, paraffin-embedded tissues: novel, pertinent markers of cell proliferation.	Paraffin	73-81	proliferating cell nuclear antigen	Homo sapiens	32-38
30226548-7	2018	MCT4 expression was associated with T stage (P=0.001), N stage (P=0.020) and formalin-fixed and paraffin-embedded (TNM) stage (P=0.042).	Paraffin	96-104	solute carrier family 16 member 3	Homo sapiens	0-4
7834077-0	1994	Heat-induced antigen retrieval of proliferating cell nuclear antigen and p53 protein in formalin-fixed, paraffin-embedded sections.	Paraffin	104-112	proliferating cell nuclear antigen	Homo sapiens	34-68
8080362-0	1994	Fiber-type differentiation by myosin immunohistochemistry on paraffin-embedded skeletal muscle.	Paraffin	61-69	myosin heavy chain 14	Homo sapiens	30-36
19538866-2	2009	METHODS: The mRNA expression of ERCC1 in formalin-fixed paraffin-embedded primary tumor specimens was measured by real-time quantitative reverse transcriptase polymerase chain reaction.	Paraffin	56-64	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	32-37
8080362-5	1994	We describe a useful alternative to determine fiber types in skeletal muscle specimens by myosin histochemistry on formalin- or Bouin-fixed, paraffin-embedded tissue.	Paraffin	141-149	myosin heavy chain 14	Homo sapiens	90-96
30344706-6	2018	Histological analysis was performed in order to examine the protein expression of ALDH1A1 and OCT4 in paraffin-embedded tissue specimens by immunohistochemical staining and the plasma levels of those two proteins was measured by ELISA.	Paraffin	102-110	aldehyde dehydrogenase 1 family member A1	Homo sapiens	82-89
7528548-9	1994	Avidin-biotin immunocytochemistry utilizing the monoclonal antibody was used to localize IGFBP-1 in paraffin sections.	Paraffin	100-108	insulin like growth factor binding protein 1	Felis catus	89-96
8027523-2	1994	Lectin histochemistry was carried out on cryostat, paraffin, and vibratome sections and was examined by light microscopy.	Paraffin	51-59	LTL	Solanum lycopersicum	0-6
19025608-4	2008	Fluorescent immunostaining of PML bodies was performed in the paraffin-embedded tumor sections.	Paraffin	62-70	PML nuclear body scaffold	Homo sapiens	30-33
30344706-6	2018	Histological analysis was performed in order to examine the protein expression of ALDH1A1 and OCT4 in paraffin-embedded tissue specimens by immunohistochemical staining and the plasma levels of those two proteins was measured by ELISA.	Paraffin	102-110	POU class 5 homeobox 1	Homo sapiens	94-98
30386718-2	2018	PD-L1 expression was evaluated by immunohistochemistry (IHC) using formalin-fixed paraffin-embedded (FFPE) specimens from 45 non-ccRCC patients with available tissue.	Paraffin	82-90	CD274 molecule	Homo sapiens	0-5
24855511-5	2008	The localization of injected-CD34+ cells was assessed on formalin-fixed, paraffin-embedded mouse skin samples by in situ hybridization technique.	Paraffin	73-81	CD34 antigen	Mus musculus	29-33
18925698-4	2008	Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue by antibody p27 and cyclin D1.	Paraffin	54-62	interferon alpha inducible protein 27	Homo sapiens	91-94
7917222-0	1994	Detection of gastrin mRNA in paraffin-embedded samples of normal antral mucosae using polymerase chain reaction technique.	Paraffin	29-37	gastrin	Homo sapiens	13-20
7917222-4	1994	Here it was proposed to detect gastrin mRNA using a RT-PCR technique on a series of paraffin-embedded samples of normal human antrum processed with various fixatives commonly used in histology.	Paraffin	84-92	gastrin	Homo sapiens	31-38
30323667-3	2018	Patients and methods: We investigated PD-L1 expression immunohistochemistry in formalin-fixed, paraffin-embedded tissues from 192 ICC patients undergoing curative resection and correlated our results with the clinicopathologic features and prognosis.	Paraffin	95-103	CD274 molecule	Homo sapiens	38-43
8018914-5	1994	Immunohistochemical analysis of paraffin sections showed an increased immunoreactivity for PAI-1 in the placental villous syncytiotrophoblasts from PE/IUGR women compared with the immunostaining of placental samples from the normal or IUGR group.	Paraffin	32-40	serpin family E member 1	Homo sapiens	91-96
8012944-3	1994	Using in situ hybridization with paraffin-embedded surgical specimens of human gliomas and normal brain tissues, PAI-1 mRNA was abundantly expressed in glioblastomas.	Paraffin	33-41	serpin family E member 1	Homo sapiens	113-118
18342921-11	2008	The LYVE-1 antibody was a useful specific marker for the illustration of the lymphatic vessel in conventional paraffin-embedded specimens of the urinary bladder.	Paraffin	110-118	lymphatic vessel endothelial hyaluronan receptor 1	Homo sapiens	4-10
20735971-0	2008	[PML expression in lung carcinomas: analysis by RT-PCR in formalin-fixed and paraffin-embedded tissue.].	Paraffin	77-85	PML nuclear body scaffold	Homo sapiens	1-4
28913610-3	2018	Immunohistochemical staining was used to verify eEF2 protein in a set of 97 formalin-fixed, paraffin-embedded primary PCa tissues.	Paraffin	92-100	eukaryotic translation elongation factor 2	Homo sapiens	48-52
17764886-3	2008	METHODS: Paraffin slides of SLNs with MIC/ITC-involvement obtained from 68 breast cancer patients were evaluated for MIC/ITC location, lesion size, and various SLN morphologic features.	Paraffin	9-17	sarcolipin	Homo sapiens	28-31
7806086-2	1994	Nevertheless, protocols for detecting GM-CSF receptors on formalin-fixed paraffin-embedded histological sections, to our knowledge, have not been described.	Paraffin	73-81	colony stimulating factor 2	Homo sapiens	38-44
21607449-7	1994	At immunohistochemistry, in paraffin sections, there was strong positivity with the reagents against CD45, CD68, alfa-1-antichymotrypsin and vimentin.	Paraffin	28-36	vimentin	Homo sapiens	141-149
30075175-5	2018	Furthermore, RT-qPCR was performed to study the expression of miR-302b in bladder cancer tissues and the prognostic value of altered miR-302b expression with 48 formalin-fixed paraffin-embedded bladder urothelial carcinoma samples.	Paraffin	176-184	microRNA 302b	Homo sapiens	133-141
7919156-2	1994	Recently, antibodies to cell proliferation-associated nuclear proteins, such as proliferating cell nuclear antigen (PCNA) and KI-67, which are applicable to archival paraffin sections, became available.	Paraffin	166-174	proliferating cell nuclear antigen	Homo sapiens	80-114
18788685-2	2008	MATERIAL AND METHOD: PTEN protein expression was evaluated by immunohistrochemical study of 70 paraffin-embedded curettage endometrial tissue samples (10 normal endometrium, 55 endometrial hyperplasia, and 15 endometrial adenocarcinomas) selected from surgical pathology files of the Division of Gynecologic Pathology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, from 2001 to 2004.	Paraffin	95-103	phosphatase and tensin homolog	Homo sapiens	21-25
18387992-6	2008	The presence of an SYT-SSX gene fusion resulting from t(X;18) was demonstrated from paraffin blocks by reverse transcriptase polymerase chain reaction in both cases.	Paraffin	84-92	SSX family member 2B	Homo sapiens	23-26
7919156-2	1994	Recently, antibodies to cell proliferation-associated nuclear proteins, such as proliferating cell nuclear antigen (PCNA) and KI-67, which are applicable to archival paraffin sections, became available.	Paraffin	166-174	proliferating cell nuclear antigen	Homo sapiens	116-120
30121007-8	2018	Immunohistochemical staining of paraffin-embedded tissue sections showed that PAICS is overexpressed in MIBC.	Paraffin	32-40	phosphoribosylaminoimidazole carboxylase and phosphoribosylaminoimidazolesuccinocarboxamide synthase	Gallus gallus	78-83
7914944-1	1994	The expression of the proliferating cell nuclear antigen (PCNA) was analyzed in formalin-fixed paraffin-embedded materials of 20 primary renal pelvic and ureteral cancers.	Paraffin	95-103	proliferating cell nuclear antigen	Homo sapiens	22-56
7914944-1	1994	The expression of the proliferating cell nuclear antigen (PCNA) was analyzed in formalin-fixed paraffin-embedded materials of 20 primary renal pelvic and ureteral cancers.	Paraffin	95-103	proliferating cell nuclear antigen	Homo sapiens	58-62
7914944-9	1994	As PCNA immunostaining can be applied to routinely processed paraffin-embedded specimen, this method is very useful to assess the cell proliferation.	Paraffin	61-69	proliferating cell nuclear antigen	Homo sapiens	3-7
18599864-0	2008	Western blot detection of PrP Sc in archived paraffin-embedded brainstem from scrapie-affected sheep.	Paraffin	45-53	major prion protein	Ovis aries	26-29
18368586-4	2008	MATERIALS AND METHODS: Immunohistochemistry for MMP-1, -9 and -13 was performed in series of 103 paraffin-embedded sections of SGC.	Paraffin	97-105	matrix metallopeptidase 1	Homo sapiens	48-65
29535130-4	2018	Quantitative p95 protein expression was measured in formalin-fixed paraffin-embedded samples using the p95 VeraTag assay (Monogram Biosciences), specific for the M611 form of p95.	Paraffin	67-75	nibrin	Homo sapiens	13-16
29750309-5	2018	Immunohistochemistry analyses conducted on formalin-fixed paraffin-embedded breast cancer tissue sections revealed that Ran expression was associated with tumor histological grade, nerve invasion and metastasis, vascular metastasis and Ki-67 expression (a marker of cell proliferation).	Paraffin	58-66	RAN, member RAS oncogene family	Homo sapiens	120-123
18547472-6	2008	Immunohistochemical staining for IDO was performed on paraffin sections of colon of two mouse models for colitis and their controls and on paraffin sections of human ileum and colon in normal and two different inflammatory conditions, namely inflammatory bowel disease and diverticulitis.	Paraffin	54-62	indoleamine 2,3-dioxygenase 1	Mus musculus	33-36
29767258-3	2018	PD-L1 mRNA expression of formalin-fixed paraffin-embedded paratumoral and intratumoral tissues was quantified by PCR.	Paraffin	40-48	CD274 molecule	Homo sapiens	0-5
18192970-5	2008	However, by taking advantage of a technique which allows for multiple fluorescent labeling of formalin-fixed paraffin-embedded archival sections, we demonstrate unambiguously that endosialin is not expressed by the glioma endothelial cells but on closely associated perivascular cells.	Paraffin	109-117	CD248 molecule	Homo sapiens	180-190
18196271-2	2008	We investigated the impact of tissue injury by preoperative sampling on the level of uPA/PAI-1 in paraffin tissue of 55 breast cancer cases by immunohistochemistry.	Paraffin	98-106	serpin family E member 1	Homo sapiens	89-94
18203297-4	2008	Intratumoral TS protein expression was studied immunohistochemically in corresponding sections from paraffin-embedded primary foci.	Paraffin	100-108	thymidylate synthetase	Homo sapiens	13-15
29853313-4	2018	METHODS AND MATERIALS: Immunohistochemical staining was performed to determine NUSAP1 protein levels in paraffin colon tumor specimens.	Paraffin	104-112	nucleolar and spindle associated protein 1	Homo sapiens	79-85
18195146-6	2008	Calbindin immunohistochemistry was performed on paraffin sections of the cerebellum.	Paraffin	48-56	calbindin 1	Homo sapiens	0-9
29462571-3	2018	Herein, we describe a novel multiplexed in situ hybridization (ISH) (RNAscope) protocol to detect HIV-DNA (vDNA) and HIV-RNA (vRNA) in formalin-fixed paraffin-embedded (FFPE) human tissues in combination with immunofluorescence (IF) phenotyping of the infected cells.	Paraffin	150-158	vault RNA 1-1	Homo sapiens	126-130
18066593-1	2008	We aimed to detect truncated CCN3 protein variants in formalin-fixed paraffin-embedded samples of eight Wilms" tumors using anti-K19M and novel domain-specific antibodies, anti-NH2, anti-NH3, anti-NH4, and anti-NH5 raised against C-terminal (CT) domain and modules 1, 2, 3, and 4 of the CCN3 protein, respectively.	Paraffin	69-77	cellular communication network factor 3	Homo sapiens	29-33
29713584-2	2018	PD-L1 immunohistochemical testing is approved for formalin-fixed, paraffin-embedded (FFPE) surgical pathology specimens; however, the testing performance on FFPE cytology cell block specimens is unknown.	Paraffin	66-74	CD274 molecule	Homo sapiens	0-5
17979543-0	2007	A novel monoclonal antibody for detection of folate receptor alpha in paraffin-embedded tissues.	Paraffin	70-78	folate receptor alpha	Homo sapiens	45-66
29568219-0	2018	Technical Validation of a Reverse-Transcription Quantitative Polymerase Chain Reaction In Vitro Diagnostic Test for the Determination of MiR-31-3p Expression Levels in Formalin-Fixed Paraffin-Embedded Metastatic Colorectal Cancer Tumor Specimens.	Paraffin	183-191	microRNA 31	Homo sapiens	137-143
17884770-2	2007	METHODS: SP immunohistochemistry was used to detect the expression of galectin-1 in 158 paraffin-embedded specimens including 30 normal mucosa, 25 adenoma, 65 colorectal carcinoma and 38 metastatic tumor specimens.	Paraffin	88-96	galectin 1	Homo sapiens	70-80
17606718-3	2007	EXPERIMENTAL DESIGN: Expression of PTEN and pAkt was detected by immunohistochemistry in paraffin-embedded prostate cancer tissue obtained from men undergoing radical prostatectomy.	Paraffin	89-97	phosphatase and tensin homolog	Homo sapiens	35-39
17606720-7	2007	METHODS AND RESULTS: Immunohistochemical expression of Prx1 and Nrf2 was evaluated in paraffin-embedded tissues from 90 patients who underwent a curative surgical resection.	Paraffin	86-94	peroxiredoxin 1	Homo sapiens	55-59
18069630-2	2007	METHODS: Methylation specific PCR (MSP) was used to examine the promoter methylation of tumor suppressor genes E-cadherin, hMLH1, APC and MGMT in paraffin-embedded gastric cancer tissue and adjacent normal foveolar epithelium in 106 cases.	Paraffin	146-154	mutL homolog 1	Homo sapiens	123-128
29474637-2	2018	Methods: The TERT promoter region in genomic DNA extracted from paraffin-embedded ovarian CCC specimens (n = 93) was bidirectionally sequenced.	Paraffin	64-72	telomerase reverse transcriptase	Homo sapiens	13-17
17663946-4	2007	MATERIAL AND METHOD: ANXA2 expression was analyzed by immunohistochemistry in paraffin-embedded sections from 9 patients with premalignant lesions and 21 patients with HNSCC.	Paraffin	78-86	annexin A2	Homo sapiens	21-26
29563809-4	2018	Patients and methods: IKBKE protein expression was evaluated by immunohistochemistry in 118 paraffin specimens of ESCC treated by curative surgery.	Paraffin	92-100	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	22-27
17394193-3	2007	METHODS: Expression and intracellular localization of HB-EGF and EGFR were examined by immunohistochemistry in paraffin-embedded specimens from 121 patients who underwent cystectomy for bladder cancer.	Paraffin	111-119	heparin binding EGF like growth factor	Homo sapiens	54-60
29563809-7	2018	Results: IKBKE expression was 61.9% (73/118) in paraffin-embedded archived ESCC.	Paraffin	48-56	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	9-14
17513515-5	2007	Fluorescence in situ hybridisation analysis performed on paraffin-wax-embedded tumour tissue revealed a mixed-lineage leukaemia (MLL) gene rearrangement, supporting the association of this malignancy with prior chemotherapy.	Paraffin	57-65	lysine methyltransferase 2A	Homo sapiens	104-127
29293100-4	2018	The polysialylated isoform of NCAM was evaluated on formalin-fixed and paraffin-embedded tissues.	Paraffin	71-79	neural cell adhesion molecule 1	Homo sapiens	30-34
17513515-5	2007	Fluorescence in situ hybridisation analysis performed on paraffin-wax-embedded tumour tissue revealed a mixed-lineage leukaemia (MLL) gene rearrangement, supporting the association of this malignancy with prior chemotherapy.	Paraffin	57-65	lysine methyltransferase 2A	Homo sapiens	129-132
17535087-3	2007	Fluorescent-labeled in-situ hybridization using the formalin-fixed, paraffin-embedded material showed that the MYCN oncogene was amplified in the latter clone but not in the former clone.	Paraffin	68-76	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	111-115
29254792-3	2018	METHODS AND METHODS: Expression of GRK3 was detected, using tissue microarray-based immunohistochemistry, in paired formalin-fixed paraffin-embedded tumor and non-tumor samples from 165 patients with PDAC after curative resection, and was further correlated with clinicopathologic parameters and cancer-specific survival (CSS).	Paraffin	131-139	G protein-coupled receptor kinase 3	Homo sapiens	35-39
29189265-4	2018	We report validation of PD-L1 IHC 28-8 pharmDx for PD-L1 detection on formalin-fixed, paraffin-embedded human melanoma specimens using Autostainer Link 48.	Paraffin	86-94	CD274 molecule	Homo sapiens	24-29
17239827-4	2007	In the present study, we compared the expression of the CB2 receptor in paraffin-embedded sections from primary brain tumors of adult and pediatric patients.	Paraffin	72-80	cannabinoid receptor 2	Homo sapiens	56-59
29189265-4	2018	We report validation of PD-L1 IHC 28-8 pharmDx for PD-L1 detection on formalin-fixed, paraffin-embedded human melanoma specimens using Autostainer Link 48.	Paraffin	86-94	CD274 molecule	Homo sapiens	51-56
29694663-5	2018	The ELA antibody was applied to 4?6-?m-thick sections obtained from paraffin blocks.	Paraffin	68-76	apelin receptor early endogenous ligand	Homo sapiens	4-7
28618047-0	2017	Focal beta-catenin mutation identified on formalin-fixed and paraffin-embedded inflammatory hepatocellular adenomas.	Paraffin	61-69	catenin beta 1	Homo sapiens	6-18
8120539-4	1994	Anti-PGP 9.5, which recognizes a neuron-associated antigen, may be used in glutaraldehyde-fixed, paraffin-embedded human sural nerve biopsies to identify unmyelinated axons.	Paraffin	97-105	ubiquitin C-terminal hydrolase L1	Homo sapiens	5-12
7516561-2	1994	Immunohistochemical staining of routinely processed formalin-fixed, paraffin-embedded archival tissue sections with proliferating cell nuclear antigen (PCNA) monoclonal antibody has facilitated the understanding of the regulation of cell proliferation.	Paraffin	68-76	proliferating cell nuclear antigen	Homo sapiens	116-150
28952196-5	2017	Direct DNA analyses of isolated MTC paraffin-embedded specimens revealed two RET proto-oncogene missense point mutations in exon 11 (i.e., C630R and C634W).	Paraffin	36-44	ret proto-oncogene	Homo sapiens	77-80
7516561-2	1994	Immunohistochemical staining of routinely processed formalin-fixed, paraffin-embedded archival tissue sections with proliferating cell nuclear antigen (PCNA) monoclonal antibody has facilitated the understanding of the regulation of cell proliferation.	Paraffin	68-76	proliferating cell nuclear antigen	Homo sapiens	152-156
7905542-6	1994	PI by PCNA/MIB1 was established using 5-microns paraffin sections, immunoperoxidase, and quantification procedures detailed in the literature.	Paraffin	48-56	proliferating cell nuclear antigen	Homo sapiens	6-10
28725522-6	2017	We performed immunohistochemical stains for beta-catenin on paraffin-embedded tissue on the index tumor and a subsequent teratocarcinosarcoma.	Paraffin	60-68	catenin beta 1	Homo sapiens	44-56
7905900-6	1994	A strong correlation (p &lt; 0.01) was noted between the rate of labeling with Ki-67 and that with PCNA in fresh specimens from the same patients and between the rate of labeling with PCNA in fresh specimens and that in paraffin-embedded specimens from the same patients.	Paraffin	220-228	proliferating cell nuclear antigen	Homo sapiens	184-188
7518293-0	1994	Frequent expression of 75 kDa nerve growth factor receptor and phosphotyrosine in human peripheral nerve tumours: an immunohistochemical study on paraffin-embedded tissues.	Paraffin	146-154	nerve growth factor receptor	Homo sapiens	30-58
28789449-8	2017	Quantification of TOMM34 and RNF43 gene expression in several-year-old paraffin-embedded colorectal cancer specimens was possible by qPCR using the Universal ProbeLibrary.	Paraffin	71-79	translocase of outer mitochondrial membrane 34	Homo sapiens	18-24
8236215-2	1993	Analysis of DNA from archival, paraffin-embedded muscle tissue allowed tracing of the mutated dystrophin gene in two families with Duchenne muscular dystrophy.	Paraffin	31-39	dystrophin	Homo sapiens	94-104
7901794-3	1993	Anti-PCNA antibody staining provides a semiquantitative estimate of the number of proliferating cells found in fixed tissue embedded in paraffin.	Paraffin	136-144	proliferating cell nuclear antigen	Homo sapiens	5-9
29137373-3	2017	Subsequently, immunohistochemical staining was performed to determine CEACAM6 protein levels in paraffin gastric tumor specimens.	Paraffin	96-104	CEA cell adhesion molecule 6	Homo sapiens	70-77
8212437-4	1993	To test these hypotheses, hsp-27 expression was evaluated by immunohistochemistry in archival formalin-fixed paraffin-embedded sections of primary prostate and bladder carcinomas where the outcome of the patient was known.	Paraffin	109-117	heat shock protein family B (small) member 1	Homo sapiens	26-32
28748483-3	2017	MicroRNA-146a and microRNA-155 were detected by in situ hybridization with digoxigenin on paraffin sections.	Paraffin	90-98	microRNA 146a	Homo sapiens	0-13
7903573-10	1993	19A2 and PC10 are two different monoclonal antibodies which can be employed to detect PCNA in paraffin-embedded tissues.	Paraffin	94-102	proliferating cell nuclear antigen	Homo sapiens	86-90
28380458-3	2017	We therefore assessed the expression of AFAP1-AS1 and PD-1 in a cohort of 96 paraffin-embedded NPC samples and confirmed that AFAP1-AS1 and PD-1 are co-expressed in infiltrating lymphocytes in NPC tissue.	Paraffin	77-85	AFAP1 antisense RNA 1	Homo sapiens	40-49
8492318-3	1993	METHODS: We identified invasive tumors with grossly detectable c-myc amplification by using Southern blot analysis to examine frozen tissue from 135 breast carcinomas and polymerase chain reaction (PCR) analysis to examine archival paraffin-embedded tissue from an additional 19 invasive tumors.	Paraffin	232-240	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	63-68
8100680-4	1993	Proliferating cell nuclear antigen (PCNA), a protein associated with DNA polymerase that is expressed only in the nuclei of cells actively synthesizing DNA, was quantitated in 46 formalin-fixed, paraffin-embedded samples of various types of NHL using the Cell Analysis Systems 200 image analyzer.	Paraffin	195-203	proliferating cell nuclear antigen	Homo sapiens	0-34
28380458-3	2017	We therefore assessed the expression of AFAP1-AS1 and PD-1 in a cohort of 96 paraffin-embedded NPC samples and confirmed that AFAP1-AS1 and PD-1 are co-expressed in infiltrating lymphocytes in NPC tissue.	Paraffin	77-85	AFAP1 antisense RNA 1	Homo sapiens	126-135
28186689-4	2017	We investigated PAI-1 mRNA expression in the paraffin blocks of patients with biopsy-proven LV and controls.	Paraffin	45-53	serpin family E member 1	Homo sapiens	16-21
8333107-11	1993	Immunohistochemical studies on paraffin-embedded sections showed positive reactivity to human T-cell Ag (clone UCHL-1) and for lysozyme, alpha-1-antitrypsin, and cathespin B. Polyclonal intracellular immunoglobulin reactivity and lectin binding (peanut, soybean, and wheat germ agglutinins and concanavalin A) were also demonstrated.	Paraffin	31-39	ubiquitin C-terminal hydrolase L1	Homo sapiens	111-117
27802183-2	2017	The presence of FGFR2 amplification was assessed in formalin-fixed, paraffin-embedded tissues using a quantitative PCR-based gene copy number assay with advanced gastric cancer cohorts.	Paraffin	68-76	fibroblast growth factor receptor 2	Homo sapiens	16-21
8099249-0	1993	[Expression of proliferating cell nuclear antigen in superficial bladder cancer--application to paraffin-embedded tissue sections].	Paraffin	96-104	proliferating cell nuclear antigen	Homo sapiens	15-49
8099249-5	1993	2) The PCNA positive rate showed no correlation with age, sex, duration of paraffin-embedded, or pathological stage, but showed a significant correlation with the number of tumors, pathological grade of malignancy, or non-recurrence rate.	Paraffin	75-83	proliferating cell nuclear antigen	Homo sapiens	7-11
8099249-8	1993	In conclusion, the method of counting the rate of PCNA positive nuclei is considered to be very useful because of its applicability to paraffin-embedded tissue sections and the simple and rapid techniques.	Paraffin	135-143	proliferating cell nuclear antigen	Homo sapiens	50-54
7684020-2	1993	They can be recognized immunohistochemically in paraffin sections by the monoclonal antibodies PC-10 and c-myc 1-9E10, respectively.	Paraffin	48-56	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	105-110
12231741-2	1993	Sucrose synthase protein was immunolocalized at the light microscope level using paraffin sections reacted with rabbit sucrose synthase polyclonal antisera and gold-conjugated goat anti-rabbit immunoglobulin G. Immunolabel was specifically observed in phloem companion cells of minor and intermediate veins in mature leaves of both species.	Paraffin	81-89	sucrose synthase 1	Zea mays	0-16
28085175-5	2017	Cathepsin K was evaluated on formalin-fixed and paraffin-embedded tissue microarrays with 5 tissue spots per case.	Paraffin	48-56	cathepsin K	Homo sapiens	0-11
8100655-4	1993	The inclusion of PCNA index, which is easily measured in paraffin-embedded sections, in the existing histopathological grading systems of duodenitis may improve their clinical relevance.	Paraffin	57-65	proliferating cell nuclear antigen	Homo sapiens	17-21
1361306-6	1992	Results indicate that PCNA labeling with PC10 is a simple method for assessing the proliferative activity in formalin-fixed, paraffin-embedded tissue of NSCLC and correlates well with Ki-67 labeling and S-phase fraction of the cell cycle.	Paraffin	125-133	proliferating cell nuclear antigen	Homo sapiens	22-26
27984126-10	2017	In this beta-catenin-activated inflammatory hepatocellular adenoma, S45 beta-catenin-activating mutation was detected on fixed tissue, embedded in paraffin without TERT promoter mutation.	Paraffin	147-155	catenin beta 1	Homo sapiens	8-20
1361755-2	1992	Proliferative cell nuclear antigen (PCNA) expression was analyzed in formalin-fixed and paraffin-embedded specimens from patients with urinary bladder cancer using three different anti-PCNA monoclonal antibodies.	Paraffin	88-96	proliferating cell nuclear antigen	Homo sapiens	36-40
27984126-10	2017	In this beta-catenin-activated inflammatory hepatocellular adenoma, S45 beta-catenin-activating mutation was detected on fixed tissue, embedded in paraffin without TERT promoter mutation.	Paraffin	147-155	catenin beta 1	Homo sapiens	72-84
17311616-5	2007	CB2 immunolocalization was studied in 38 samples in paraffin blocks using immunohistochemistry, and a computerized semiquantitative analysis was carried out.	Paraffin	52-60	cannabinoid receptor 2	Homo sapiens	0-3
29120119-2	2017	Immunohistochemistry was performed on formalin-fixed, paraffin-embeddedtissue by the RET, p27 and cyclin D1 antibodies.	Paraffin	54-62	ret proto-oncogene	Homo sapiens	85-88
29120119-2	2017	Immunohistochemistry was performed on formalin-fixed, paraffin-embeddedtissue by the RET, p27 and cyclin D1 antibodies.	Paraffin	54-62	interferon alpha inducible protein 27	Homo sapiens	90-93
1394214-3	1992	We screened a panel of mouse monoclonal antibodies that we raised against recombinant human c-myc and N-myc proteins for recognition of myc proteins in paraffin tissue sections.	Paraffin	152-160	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	92-97
1394214-3	1992	We screened a panel of mouse monoclonal antibodies that we raised against recombinant human c-myc and N-myc proteins for recognition of myc proteins in paraffin tissue sections.	Paraffin	152-160	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	102-107
28536704-3	2017	Immunohistochemical staining of calpain-1 was performed on paraffin-embedded tissues to correlate its expression with clinicopathological variables and outcome.	Paraffin	59-67	calpain 1	Homo sapiens	32-41
1337870-1	1992	The expression of oncogene N-ras mRNA and c-myc mRNA in paraffin embedded liver tissues from patients with hepatitis B virus (HBV) infection had been studied by in situ hybridization with biotin labeled probes.	Paraffin	56-64	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	42-47
17110616-1	2007	Immunohistochemical studies on formalin-fixed, paraffin-embedded (FFPE) tissue utilizing polyclonal antibodies form the cornerstone of many reports claiming to demonstrate erythropoietin receptor (EPOR) expression in malignant tissue.	Paraffin	47-55	erythropoietin receptor	Homo sapiens	172-195
17110616-1	2007	Immunohistochemical studies on formalin-fixed, paraffin-embedded (FFPE) tissue utilizing polyclonal antibodies form the cornerstone of many reports claiming to demonstrate erythropoietin receptor (EPOR) expression in malignant tissue.	Paraffin	47-55	erythropoietin receptor	Homo sapiens	197-201
17535680-2	2007	METHODS: Immunohistochemistry EnVision method was used to detect E-cadherin and beta-catenin expression in 90 paraffin-embedded tissue samples of neuroblastomas.	Paraffin	110-118	catenin beta 1	Homo sapiens	80-92
28819937-3	2017	MATERIAL AND METHODS: In this study, we investigated A5935G, G5949A, G6081A, G6267A mutations in MT-CO1 and T9540C in MT-CO3, and alterations detected during the analysis of MT-CO gene fragments in formalin-fixed, paraffin-embedded endometrial and benign endometrial hyperplasia of a cohort of 125 subjects.	Paraffin	214-222	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	97-103
17360651-4	2007	Here we generated a new Ab against PD-1 ligand 1 (PD-L1) and analyzed the expression level of PD-Ls in human ovarian cancer using paraffin-embedded specimens.	Paraffin	130-138	CD274 molecule	Homo sapiens	35-48
1363339-2	1992	Recently, a monoclonal antibody against the proliferating cell nuclear antigen (PCNA or cyclin), a nuclear protein expressed in proliferating cells, was developed which could be used on formalin fixed, paraffin embedded tissue.	Paraffin	202-210	proliferating cell nuclear antigen	Homo sapiens	44-78
1363339-2	1992	Recently, a monoclonal antibody against the proliferating cell nuclear antigen (PCNA or cyclin), a nuclear protein expressed in proliferating cells, was developed which could be used on formalin fixed, paraffin embedded tissue.	Paraffin	202-210	proliferating cell nuclear antigen	Homo sapiens	80-84
1363339-2	1992	Recently, a monoclonal antibody against the proliferating cell nuclear antigen (PCNA or cyclin), a nuclear protein expressed in proliferating cells, was developed which could be used on formalin fixed, paraffin embedded tissue.	Paraffin	202-210	proliferating cell nuclear antigen	Homo sapiens	88-94
1349455-0	1992	Proliferating cell nuclear antigen counts in formalin-fixed paraffin-embedded tissue correlate with Ki-67 in fresh tissue.	Paraffin	60-68	proliferating cell nuclear antigen	Homo sapiens	0-34
17441427-2	2007	METHOD: SP immunohistochemical method was used for the assays of CTGF and OPN on the routinely paraffin-embedded sections of surgical operated specimens of 41 cases with laryngeal squamous cell carcinoma and 20 ones with paracancerous tissues.	Paraffin	95-103	secreted phosphoprotein 1	Homo sapiens	74-77
27574810-8	2017	All 4 PUTIPs with formalin-fixed, paraffin-embedded material available were positive for the TERT promoter mutation 228G&gt;A by polymerase chain reaction and were microsatellite stable.	Paraffin	34-42	telomerase reverse transcriptase	Homo sapiens	93-97
17117392-6	2007	The development of commercially available OCT4-specific antibodies suitable for immunohistochemistry on paraffin-embedded specimens has generated increasing numbers of reports of OCT4 expression in a wide variety of gonadal and extragonadal GCTs.	Paraffin	104-112	POU class 5 homeobox 1	Homo sapiens	42-46
1532404-2	1992	First, these methods were compared in immunohistochemical model systems, using the demonstration of glial fibrillar acidic protein (GFAP) and prostate-specific antigen (PSA) in paraffin sections of human brain and prostate tissue, respectively.	Paraffin	177-185	kallikrein related peptidase 3	Homo sapiens	142-173
1381429-2	1992	In this study we used the monoclonal antibody NCL-PCNA (clone PC-10) against the proliferating cell nuclear antigen (PCNA) to detect cycling cells in paraffin sections of 3 normal livers, 14 post-mortem needle-specimens of submassive hepatic necrosis (SHN) due to paracetamol overdosage (POD), and 10 hepatectomy specimens obtained at transplantation in patients with acute or subacute liver failure of presumed viral aetiology.	Paraffin	150-158	proliferating cell nuclear antigen	Homo sapiens	117-121
27734400-4	2017	This chapter describes a detailed in situ hybridization technique for the detection of CCN1 and CCN5 in formalin-fixed, paraffin-embedded patient samples of breast and pancreatic cancers.	Paraffin	120-128	cellular communication network factor 1	Homo sapiens	87-91
27941992-4	2016	Immunohistochemistry was performed to detect the expression of KIF20A in paraffin-embedded specimens from 169 early-stage cervical squamous cell carcinoma patients.	Paraffin	73-81	kinesin family member 20A	Homo sapiens	63-69
1544220-4	1992	beta 2-microglobulin (beta 2-MG) expression on hepatocytes was semiquantified using a scoring system on sections from paraffin-embedded biopsy specimens.	Paraffin	118-126	beta-2-microglobulin	Homo sapiens	0-20
1357920-6	1992	This suggests that the immunohistochemical staining for PCNA in paraffin sections is a good alternative to the BrdU labelling index.	Paraffin	64-72	proliferating cell nuclear antigen	Homo sapiens	56-60
18427598-15	2007	CONCLUSION: This study successfully analyzes HtrA1 SNP and transcript expression in microdissected cells from archived paraffin fixed slides.	Paraffin	119-127	HtrA serine peptidase 1	Homo sapiens	45-50
17063086-6	2006	Immunohistochemical analysis of routinely processed paraffin-embedded bone marrow sections showed that CBFbeta-SMMHC staining is predominantly nuclear in all cases of AML-M4Eo and is not nuclear in other AML types.	Paraffin	52-60	core-binding factor subunit beta	Homo sapiens	103-110
27666346-2	2016	FRMD4A antibodies were used to probe 78 paraffin-embedded specimens of tongue squamous cell carcinoma and 15 normal tongue tissues, which served as controls.	Paraffin	40-48	FERM domain containing 4A	Homo sapiens	0-6
16793127-7	2006	Immunohistochemical PTEN expression was done on paraffin-embedded material.	Paraffin	48-56	phosphatase and tensin homolog	Homo sapiens	20-24
1612556-4	1992	7B2 was positively stained in a paraffin-embedded section of gonadotropin-producing pituitary adenoma obtained at surgery.	Paraffin	32-40	secretogranin V	Homo sapiens	0-3
1359701-2	1992	Immunohistochemical detection of proliferating cell nuclear antigen (PCNA) has been suggested as a new approach for determining proliferative activity in paraffin-embedded tissue.	Paraffin	154-162	proliferating cell nuclear antigen	Homo sapiens	33-67
27717372-2	2016	Here we describe a PD-L1 immunohistochemical (IHC) staining protocol developed by Ventana Medical Systems Inc. and key analytical parameters of its use in formalin-fixed, paraffin-embedded (FFPE) samples of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC).	Paraffin	171-179	CD274 molecule	Homo sapiens	19-24
1359701-2	1992	Immunohistochemical detection of proliferating cell nuclear antigen (PCNA) has been suggested as a new approach for determining proliferative activity in paraffin-embedded tissue.	Paraffin	154-162	proliferating cell nuclear antigen	Homo sapiens	69-73
1359701-7	1992	In paraffin sections PCNA could be detected after methacarn fixation as well as after controled fixation at 4 degrees C in 4% paraformaldehyde for 1 h and in most biopsies routinely fixed with 10% formalin.	Paraffin	3-11	proliferating cell nuclear antigen	Homo sapiens	21-25
16870376-3	2006	The regulation of fibronectin splicing was studied by immunohistochemistry by using monoclonal antibody to EIIIA on sections from paraffin embedded rat skin sample after contusion.	Paraffin	130-138	fibronectin 1	Rattus norvegicus	18-29
27166394-4	2016	Copy number alterations of the PD-L1 gene in 11 cases were assessed in formalin-fixed, paraffin-embedded material using qRT-PCR.	Paraffin	87-95	CD274 molecule	Homo sapiens	31-36
16646082-9	2006	Paraffin-embedded tissue sections from the rat prostate tumor were used to detect base level expression of heat shock protein 70 (HSP70) and p53.	Paraffin	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	107-128
16646082-9	2006	Paraffin-embedded tissue sections from the rat prostate tumor were used to detect base level expression of heat shock protein 70 (HSP70) and p53.	Paraffin	0-8	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	130-135
1854611-3	1991	In this study paraffin sections of 483 primary breast cancers were stained with NCRC-11 and 3E1.2 using an immunoperoxidase system.	Paraffin	14-22	RNA, U105B small nucleolar	Homo sapiens	93-97
27259009-4	2016	beta-catenin immunohistochemistry was performed on formalin-fixed, paraffin-embedded whole sections from 73 tumors.	Paraffin	67-75	catenin beta 1	Homo sapiens	0-12
1675840-4	1991	The authors describe a method for detection of PCNA/Cyclin in formalin-fixed, paraffin-embedded tissue using a routine biotin-streptavidin immunohistochemical system that employs an anti-IgM, mu-chain-specific second-stage antibody.	Paraffin	78-86	proliferating cell nuclear antigen	Homo sapiens	47-58
1989459-5	1991	Immunoperoxidase stains on paraffin sections showed staining of the cells for vimentin only; there was no staining for keratin, S-100 protein, desmin, and actin.	Paraffin	27-35	vimentin	Homo sapiens	78-86
16651388-7	2006	Development of this novel NK1 receptor antibody allows the efficient localization of NK1 receptor protein in human formalin-fixed, paraffin-embedded tissues.	Paraffin	131-139	tachykinin receptor 1	Homo sapiens	26-29
16651388-7	2006	Development of this novel NK1 receptor antibody allows the efficient localization of NK1 receptor protein in human formalin-fixed, paraffin-embedded tissues.	Paraffin	131-139	tachykinin receptor 1	Homo sapiens	26-38
16844561-3	2006	A monoclonal antibody (clone Tel-24) that allows for the detection of human telomerase reverse transcriptase (hTERT) in paraffin blocks of archival material has recently been developed.	Paraffin	120-128	telomerase reverse transcriptase	Homo sapiens	110-115
29798051-1	2016	Objective:To investigate the expression of has-miR-93-5p on human laryngeal squamous cell carcinoma and the influence on malignant phenotype of Hep-2 cell.Method:The expression of has-miR-93-5p of paraffin samples in LSCC was determined by looped-primer Real-time PCR, and the relationship between the expression and the clinical pathological parameters was analysed.	Paraffin	197-205	microRNA 9-3	Homo sapiens	184-190
16418208-3	2006	DESIGN: hPTTG expression was analyzed by immunostaining on paraffin-embedded tissues.	Paraffin	59-67	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	8-13
2017657-2	1991	Immunohistochemical stainings with the anti-hsp 65 antibody on paraffin sections from normal rat joints revealed a weak but exclusive staining of cells within the synovial lining.	Paraffin	63-71	heat shock protein family D (Hsp60) member 1	Rattus norvegicus	44-50
1719695-3	1991	LN-1 also stained resting microglia in paraffin sections first treated with protease.	Paraffin	39-47	phytanoyl-CoA 2-hydroxylase	Homo sapiens	0-4
1719695-6	1991	However, LN-1 recognized a small number of astrocytes in routine paraffin sections.	Paraffin	65-73	phytanoyl-CoA 2-hydroxylase	Homo sapiens	9-13
16484001-9	2006	CONCLUSION: As a result, being cheap and simple methods, Ki-67 and hTERT immunohistochemistries can be used in differentiating malignant and benign mesothelial lesions in routine formalin-fixed, paraffin-embedded material.	Paraffin	195-203	telomerase reverse transcriptase	Homo sapiens	67-72
27050369-1	2016	To examine the relationship between cytotoxic T lymphocyte antigen-4 (CTLA-4) expression and esophageal carcinoma prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded primary tumor specimens from 158 patients with esophageal cancer.	Paraffin	181-189	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	125-131
16428479-7	2006	In fact, overexpression of the BUB1B protein is a marker that recognizes nearly 80% of breast cancers in paraffin-embedded tissues.	Paraffin	105-113	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	31-36
2247374-11	1990	In addition, we provide further evidence that the panel of monoclonal antibodies LN1, LN2, MB2, and UCHL1 is useful for immunophenotypic characterization of brain lymphomas when only paraffin embedded stereotactic biopsy tissue is available.	Paraffin	183-191	phytanoyl-CoA 2-hydroxylase	Homo sapiens	81-84
26643896-6	2016	As a result, MTUS1 levels were found to be diminished in formalin-fixed, paraffin-embedded (FFPE) tissue samples of CRC patients compared to controls.	Paraffin	73-81	microtubule associated scaffold protein 1	Homo sapiens	13-18
1699393-0	1990	Study of vimentin expression in non-Hodgkin"s lymphoma using paraffin sections.	Paraffin	61-69	vimentin	Homo sapiens	9-17
16864174-2	2006	Gene copy number of TOP2A and HER2 were analysed with chromogenic in situ hybridization (CISH) on paraffin-embedded tissue sections from the primary tumour of 85 patients treated with anthracycline containing chemotherapy.	Paraffin	98-106	DNA topoisomerase II alpha	Homo sapiens	20-25
1688901-0	1990	Establishment of specific monoclonal antibodies against recombinant human granulocyte colony-stimulating factor (hG-CSF) and their application for immunoperoxidase staining of paraffin-embedded sections.	Paraffin	176-184	colony stimulating factor 3	Homo sapiens	74-111
27076758-2	2016	METHODS: PTEN protein expression was assessed by immunohistochemistry in formalin-fixed, paraffin-embedded liver sections of patients with non-alcoholic fatty liver disease (NAFLD) (n = 44) or alcoholic liver disease (ALD) (n = 25).	Paraffin	89-97	phosphatase and tensin homolog	Homo sapiens	9-13
1688901-0	1990	Establishment of specific monoclonal antibodies against recombinant human granulocyte colony-stimulating factor (hG-CSF) and their application for immunoperoxidase staining of paraffin-embedded sections.	Paraffin	176-184	colony stimulating factor 3	Homo sapiens	113-119
1970228-6	1990	Colocalization experiments on 1-2 microns thin consecutive paraffin sections revealed a large number of NPY neurons throughout the human neostriatum and amygdaloid complex that were also positive for somatostatin.	Paraffin	59-67	neuropeptide Y	Homo sapiens	104-107
16471328-3	2005	The aim of this study was to detect hTERT protein expression in multistep oral carcinogenesis using paraffin embedded tissue samples, and to study the relationship of hTERT expression with different histological stages in oral carcinogenesis.	Paraffin	100-108	telomerase reverse transcriptase	Homo sapiens	36-41
16142418-2	2005	To test whether it is possible to detect the SYT-SSX mRNA on archival formalin-fixed paraffin-embedded SS tissue sections using PCR-based in situ amplification technique, we performed reverse transcription-polymerase chain reaction in situ hybridization (RT-PCR ISH) for the SYT-SSX fusion gene mRNA.	Paraffin	85-93	SSX family member 2B	Homo sapiens	49-52
26826553-5	2016	The expression of ETS-1 was analyzed in 71 paraffin-embedded tissue biopsies and eight fresh frozen biopsies obtained from LSCC patients.	Paraffin	43-51	ETS proto-oncogene 1, transcription factor	Homo sapiens	18-23
19956519-4	2005	Immunohistochemical study for Maspin protein expression was carried out using 62 paraffin-embedded tissues, composed of both cancer and noncancerous tissues.	Paraffin	81-89	serpin family B member 5	Homo sapiens	30-36
2280084-3	1990	We present 51 paraffin embedded pT1 bladder cancer ADN content measured by flowcytometry.	Paraffin	14-22	zinc finger protein 77	Homo sapiens	32-35
26731648-0	2016	Improving the Prediction of Prostate Cancer Overall Survival by Supplementing Readily Available Clinical Data with Gene Expression Levels of IGFBP3 and F3 in Formalin-Fixed Paraffin Embedded Core Needle Biopsy Material.	Paraffin	173-181	insulin like growth factor binding protein 3	Homo sapiens	141-147
2190198-10	1990	Our results demonstrate that the monoclonal antibody MT1 serves as an additional marker for LCH and, together with S-100 protein, would make up a diagnostic panel of antibodies for LCH to be used on routine paraffin-embedded sections.	Paraffin	207-215	metallothionein 1I, pseudogene	Homo sapiens	53-56
16042314-3	2005	We propose and test a simple staging protocol based on the presence of alpha-syn immunoreactivity in 5 paraffin sections that, taken together, contain up to 8 vulnerable brain regions.	Paraffin	103-111	synuclein alpha	Homo sapiens	71-80
15876789-3	2005	Immunoreactivity for IGF-I was detected on the paraffin sections of livers from the fed and refed chickens after the treatment with the antigen retrieval agent.	Paraffin	47-55	insulin like growth factor 1	Gallus gallus	21-26
27039774-4	2016	MATERIALS AND METHODS: Genetic analysis of the ERCC1 C8092A polymorphism was performed by the PCR - RFLP method using 50 paraffin-embedded tissue specimens.	Paraffin	121-129	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	47-52
15817147-1	2005	The present study was designed to evaluate the efficacy of different microwave pretreatment methods to retrieve microtubule-associated protein 2 (MAP-2) immunoreactivity in formalin-fixed, paraffin-embedded guinea pig brain sections.	Paraffin	189-197	microtubule-associated protein 2	Cavia porcellus	112-144
15817147-1	2005	The present study was designed to evaluate the efficacy of different microwave pretreatment methods to retrieve microtubule-associated protein 2 (MAP-2) immunoreactivity in formalin-fixed, paraffin-embedded guinea pig brain sections.	Paraffin	189-197	microtubule-associated protein 2	Cavia porcellus	146-151
15786820-4	2005	METHODS: Real-time RT-PCR was performed for complement component C3 and heme oxygenase-1 (HO-1) genes compared to the housekeeping gene beta-actin using whole section RNA extracted from formalin-fixed and paraffin-embedded archival material of 16 explanted, rejected renal allografts.	Paraffin	205-213	heme oxygenase 1	Homo sapiens	90-94
34592321-6	2021	Our results showed that the ischemic area on the MAP2-stained sections could be identified macroscopically on both cryo-preserved and paraffin-embedded sections from both immersion- and perfusion-fixed brains.	Paraffin	134-142	microtubule-associated protein 2	Rattus norvegicus	49-53
34909451-2	2021	In this manuscript, we share a reliable immunohistochemistry (IHC) protocol for CD45 staining in sections of paraffin-embedded mouse kidney.	Paraffin	109-117	protein tyrosine phosphatase, receptor type, C	Mus musculus	80-84
26708598-3	2016	MATERIAL AND METHODS: The presence of MPS1/S27, was screened in paraffin-embedded human adult brain specimens processed for tissue inmunohistochemistry.	Paraffin	64-72	ribosomal protein S27	Homo sapiens	38-42
26708598-3	2016	MATERIAL AND METHODS: The presence of MPS1/S27, was screened in paraffin-embedded human adult brain specimens processed for tissue inmunohistochemistry.	Paraffin	64-72	ribosomal protein S27	Homo sapiens	43-46
34276540-2	2021	The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission tomography (PET) radiotracer (18F)PI-2620 with immunohistochemically determined tau-protein load in both formalin-fixed paraffin-embedded (FFPE) and frozen tissue samples of patients with Alzheimer"s disease (AD) and Progressive Supranuclear Palsy (PSP).	Paraffin	258-266	microtubule associated protein tau	Homo sapiens	116-119
34276540-2	2021	The purpose of this study was to correlate quantification of autoradiography signal using the novel next-generation tau positron emission tomography (PET) radiotracer (18F)PI-2620 with immunohistochemically determined tau-protein load in both formalin-fixed paraffin-embedded (FFPE) and frozen tissue samples of patients with Alzheimer"s disease (AD) and Progressive Supranuclear Palsy (PSP).	Paraffin	258-266	microtubule associated protein tau	Homo sapiens	218-221
15676009-7	2005	The paraffin sections gave an additional 23 SLN-positive cases.	Paraffin	4-12	sarcolipin	Homo sapiens	44-47
26546452-7	2015	We demonstrate that 9A11, as well as two other cytoplasmic domain-specific mAbs, E1L3N and SP142, can clearly delineate the membrane of PD-L1-positive cells in formalin-fixed paraffin-embedded tissue and facilitate interpretation of staining results.	Paraffin	175-183	CD274 molecule	Homo sapiens	136-141
26708178-6	2015	In this paper we have evaluated the GPX4 and GPX7 expression in some paraffin-embedded tissues from liver biopsy of patients with hepatitis C virus (HCV)-related cirrhosis and HCC by immunohistochemistry and RT-qPCR analysis.	Paraffin	69-77	glutathione peroxidase 4	Homo sapiens	36-40
25895987-6	2015	PrP(res) was detected in tissues by a paraffin-embedded tissue blot technique and a semiquantitative Western immunoblot assay.	Paraffin	38-46	PRP@	Bos taurus	0-3
23045122-7	2005	Since the methods amplify relatively small segments of NAT1 or NAT2, they are effective for human DNA samples derived from buccal cells or paraffin-embedded tissues.	Paraffin	139-147	N-acetyltransferase 1	Homo sapiens	55-59
15660650-0	2005	The application of a monoclonal antibody to CD62L on paraffin-embedded tissue samples in the assessment of the cutaneous T-cell infiltrates.	Paraffin	53-61	selectin L	Homo sapiens	44-49
15660650-8	2005	Both CD62L and CD7 in paraffin-embedded, formalin-fixed tissue are useful diagnostic adjuncts, especially in regard to the discrimination of lymphomatoid hypersensitivity reactions from true endogenous T-cell dyscrasia.	Paraffin	22-30	selectin L	Homo sapiens	5-10
15639799-4	2005	Total alpha-synuclein protein was significantly increased in AD and concentrated within the lipid-associated fraction (soluble:lipid ratio 0.9-/+0.05, soluble:insoluble 1.5-/+0.1, lipid:insoluble 1.7-/+0.1) which proved difficult to localize in paraffin-embedded tissue.	Paraffin	245-253	synuclein alpha	Homo sapiens	6-21
15792119-7	2005	Using formalin-fixed and paraffin-embedded tissues, immunostaining for cytokeratins and CEA of the lymph node containing necrotic carcinoma may provide clinically valuable information.	Paraffin	25-33	CEA cell adhesion molecule 5	Homo sapiens	88-91
15619215-8	2004	Our study demonstrates the suitability of in situ hybridization with MLH1 and MSH2 probes for paraffin-embedded tissue.	Paraffin	94-102	mutL homolog 1	Homo sapiens	69-73
15491968-1	2004	Hepatocyte paraffin 1 (Hep Par 1) is a monoclonal antibody developed from hepatic tissue from a failed liver allograft.	Paraffin	11-19	Prader Willi/Angelman region RNA 1	Homo sapiens	27-32
15506826-6	2004	In the next part of the study (paraffin-embedded tissue), BMPs were expressed by a variety of tumors, irrespective of the radiological nature (blastic or lytic) of their metastases.Conclusions.-We conclude that BMP production alone cannot explain bone formation, and other factors either alone or in combination may be responsible for blastic metastases to the skeleton and for bone formation by primary bone lesions, such as fibrous dysplasia.	Paraffin	31-39	bone morphogenetic protein 1	Homo sapiens	58-61
15715408-2	2004	METHOD: The SABC immunohistochemistry method was employed to detect the expression of PTEN in paraffin-embedded nasopharyngeal carcinoma tissues.	Paraffin	94-102	phosphatase and tensin homolog	Homo sapiens	86-90
15361372-4	2004	mRNA expression of maspin was investigated on snap frozen and paraffin embedded synovial tissue sections by in situ hybridisation.	Paraffin	62-70	serpin family B member 5	Homo sapiens	19-25
15334206-5	2004	CD95 (anti-CD95) was detected by an immunoperoxidase technique in paraffin sections using the catalyzed amplification system.	Paraffin	66-74	Fas cell surface death receptor	Homo sapiens	0-4
15334206-5	2004	CD95 (anti-CD95) was detected by an immunoperoxidase technique in paraffin sections using the catalyzed amplification system.	Paraffin	66-74	Fas cell surface death receptor	Homo sapiens	11-15
15297163-3	2004	In addition, SCCE expression was evaluated by immunohistochemistry on paraffin-embedded tumor tissue.	Paraffin	70-78	kallikrein related peptidase 7	Homo sapiens	13-17
15297163-8	2004	Immunohistochemistry staining of paraffin-embedded cervical cancer specimens confirmed SCCE expression in tumor cells and its absence on normal cervical epithelial cells.	Paraffin	33-41	kallikrein related peptidase 7	Homo sapiens	87-91
15363318-2	2004	METHODS: Differential polymerase chain reaction (D-PCR) with serial dilution assay was used to quantify the MYCN gene copy number in 33 paraffin-embedded tissue samples of NB.	Paraffin	136-144	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	108-112
15118903-3	2004	In this study, immunohistochemistry for DNase gamma was performed on paraffin sections of rodent liver in well-defined models of hepatocyte apoptosis induced by Fas antibody (Fas) or cycloheximide (CHX), and necrosis induced by lipopolysaccharide (LPS) or carbon tetrachloride (CCl4).	Paraffin	69-77	deoxyribonuclease 1 like 3	Homo sapiens	40-51
15142461-3	2004	METHODS: The expression of MMP-7 in 70 samples with paraffin-embedded laryngeal cancer and corresponding para-tumor normal mucosas were using immunohistochemical technique.	Paraffin	52-60	matrix metallopeptidase 7	Homo sapiens	27-32
15138841-4	2004	Immunohistochemical staining of paraffin-embedded sections after antigen-retrieval treatment with autoclaving revealed staining for ERalpha in submucosal interstitial cells, and double staining identified these cells as a subtype of intestinal macrophages.	Paraffin	32-40	estrogen receptor 1 (alpha)	Mus musculus	132-139
15138842-4	2004	We have tested commercially available anti-hTERT antibodies in formalin-fixed and paraffin-embedded human tissues by IHC.	Paraffin	82-90	telomerase reverse transcriptase	Homo sapiens	43-48
21215008-2	2004	METHODS: Expression of PTEN and FasL proteins was examined in forty-two paraffin-embedded SCLC samples and sixteen pulmonary benign disease tissues by SP immunohistochemical technique.	Paraffin	72-80	phosphatase and tensin homolog	Homo sapiens	23-27
21215008-2	2004	METHODS: Expression of PTEN and FasL proteins was examined in forty-two paraffin-embedded SCLC samples and sixteen pulmonary benign disease tissues by SP immunohistochemical technique.	Paraffin	72-80	Fas ligand	Homo sapiens	32-36
15584653-8	2004	Thus (i) PTEN immunoexpression in endometrial paraffin sections is a new diagnostic tool, distinguishing PTEN-positive cyclic abnormal monoclonal proliferative endometrium (anovulatory, non atypical, simple and complex hyperplasia) from PTEN-negative (or decreased) endometrial neoplasia, and especially early endometrial neoplasia (atypical simple and complex hyperplasia, in situ carcinoma, superficial carcinoma with focal invasion).	Paraffin	46-54	phosphatase and tensin homolog	Homo sapiens	9-13
14959847-4	2003	Up to now, no systematic analysis of the expression pattern of CD56 in formalin fixed paraffin embedded bone marrow biopsies of acute leukemias has been performed.	Paraffin	86-94	neural cell adhesion molecule 1	Homo sapiens	63-67
14959847-10	2003	On paraffin embedded bone marrow biopsies CD56 expression occurs in de novo AML with an overall frequency of 13%.	Paraffin	3-11	neural cell adhesion molecule 1	Homo sapiens	42-46
14514922-4	2003	METHODS: The expression of Wnt2, Wnt5a, Wnt5b, Wnt7b, and Wnt10b was defined by in situ, antisense RNA hybridisation of paraffin wax embedded sections of benign naevi and malignant melanoma.	Paraffin	120-132	Wnt family member 7B	Homo sapiens	47-52
12838314-2	2003	We report here that, by immunohistochemical staining of paraffin-embedded tumour sections, GrB protein was unexpectedly detected in malignant cells of a subset of breast cancers and their adjacent reactive endothelial and mesenchymal cells in which endogenous retinoblastoma protein (pRB) is overexpressed.	Paraffin	56-64	granzyme B	Homo sapiens	91-94
12821344-5	2003	METHODS: Using immunohistochemistry, we investigated FasL expression in sections of formalin-fixed, paraffin-embedded tissue from 24 cervical adenocarcinomas.	Paraffin	100-108	Fas ligand	Homo sapiens	53-57
12971412-6	2003	The p53-dependent apoptosis related Bax proteins on formalin-fixed paraffin-embedded sections were stained by the avidin-biotin peroxidase complex method.	Paraffin	67-75	transformation related protein 53, pseudogene	Mus musculus	4-7
12564766-3	2002	FKBP12 immunoreactivity was associated with lipofuscin in formalin-fixed paraffin-embedded samples.	Paraffin	73-81	FKBP prolyl isomerase 1A pseudogene 4	Homo sapiens	0-6
12444553-6	2002	Immunohistochemical studies on formalin-fixed, paraffin-embedded tissues revealed hPTTG in 38.8% of B-cell lymphomas, 70.2% of T-cell lymphomas, and 73.1% of Hodgkin"s lymphomas.	Paraffin	47-55	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	82-87
12215298-2	2002	METHODS: EP(1) and FP receptor mRNAs were detected by riboprobes labeled with digoxigenin on paraffin sections of the iris-ciliary body tissue of the human eye using in situ hybridization.	Paraffin	93-101	prostaglandin E receptor 1	Homo sapiens	9-14
12161537-4	2002	We here report on RET protein immunoreactivity in paraffin-embedded thyroid samples from 30 patients with papillary thyroid cancer who received radiation treatment during childhood for benign conditions at Michael Reese Hospital in Chicago, and in 34 patients identified from the tumor registry as having papillary thyroid cancer with no history of therapeutic radiation.	Paraffin	50-58	ret proto-oncogene	Homo sapiens	18-21
21320401-4	2002	Immunohistochemical methods were employed to detect the expression of cyclin D1 and p53 in paraffin-embeded tissues.	Paraffin	91-99	transformation related protein 53, pseudogene	Mus musculus	84-87
11805515-6	2002	Immunohistochemistry was performed to localize FasL protein in paraffin sections of rabbit corneas.	Paraffin	63-71	LOW QUALITY PROTEIN: tumor necrosis factor ligand superfamily member 6	Oryctolagus cuniculus	47-51
11866985-1	2001	OBJECTIVE: To demonstrate that a characteristic SYT-SSX fusion gene resulting from chromosomal translocation t (X; 18) (p11; q11) was detectable in archival paraffin-embedded synovial sarcoma tissues.	Paraffin	157-165	endonuclease, poly(U) specific	Homo sapiens	120-123
11690683-3	2001	PATIENTS AND METHODS: Bcl-2, Bax and p21 positivity were detected immunohistochemically on paraffin-embedded pre-treatment biopsies from 83 patients with invasive transitional cell cancer (TCC) of the bladder, treated with radiotherapy.	Paraffin	91-99	H3 histone pseudogene 16	Homo sapiens	37-40
11530074-3	2001	Immunohistochemistry with antibodies against Fas-ligand was performed on paraffin-embedded sections of 23 human eye bank eyes (aged 45 to 96 years) and 12 eyes with exudative age-related maculopathy.	Paraffin	73-81	Fas ligand	Homo sapiens	45-55
11579948-4	2001	METHODS: The expression of CD5 on lymphoma cells was examined using flow cytometry and immunohistochemical analysis of paraffin sections.	Paraffin	119-127	CD5 molecule	Homo sapiens	27-30
11511839-7	2001	CD7 deletion and TCR-gamma PCR was sensitive (94%) and specific (96%) for a diagnosis of MF using paraffin-embedded biopsy specimens.	Paraffin	98-106	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	17-20
11511839-8	2001	CONCLUSION: In the diagnosis of MF, detection of CD7 deletion and monoclonal TCR rearrangements can be successfully performed in a cost-effective, timely fashion using routine formalin-fixed paraffin-embedded biopsy specimens.	Paraffin	191-199	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	77-80
11479861-3	2001	METHODS: Immunohistochemistry staining of paraffin-embedded appendices was performed with GAP-43, VIP, and SP.	Paraffin	42-50	growth associated protein 43	Homo sapiens	90-96
11579677-5	2001	Thirty-five paraffin-embedded PTC samples from patients without a history of radiation exposure were studied.	Paraffin	12-20	ret proto-oncogene	Homo sapiens	30-33
11579678-6	2001	We also analyzed immunohistochemical expression of alpha-, beta-, and gamma-catenin by paraffin sections from 154 pituitary tumors, including 148 adenomas and 6 carcinomas.	Paraffin	87-95	catenin beta 1	Homo sapiens	51-83
11812320-2	2001	METHODS: HPV16 DNA and human telomerase reverse transcriptase (hTRT) mRNA were detected in 82 cases of paraffin embedded tissues including 7 cases of normal oral mucosa, 7 cases of hyperplasia lesions, 30 cases of oral dysplasia lesions and 38 cases of oral squamous cell carcinomas (OSCCs) by PCR and in situ hybridization (ISH) respectively.	Paraffin	103-111	telomerase reverse transcriptase	Homo sapiens	29-61
11812320-2	2001	METHODS: HPV16 DNA and human telomerase reverse transcriptase (hTRT) mRNA were detected in 82 cases of paraffin embedded tissues including 7 cases of normal oral mucosa, 7 cases of hyperplasia lesions, 30 cases of oral dysplasia lesions and 38 cases of oral squamous cell carcinomas (OSCCs) by PCR and in situ hybridization (ISH) respectively.	Paraffin	103-111	telomerase reverse transcriptase	Homo sapiens	63-67
11159207-0	2001	API2-MALT1 fusion transcripts involved in mucosa-associated lymphoid tissue lymphoma: multiplex RT-PCR detection using formalin-fixed paraffin-embedded specimens.	Paraffin	134-142	baculoviral IAP repeat containing 3	Homo sapiens	0-4
11159207-11	2001	Our multiplex RT-PCR assay, which can be used for routinely-processed paraffin samples, should serve as a useful molecular tool for clarifying the clinicopathological significance of API2-MALT1 fusion in MALT lymphoma.	Paraffin	70-78	baculoviral IAP repeat containing 3	Homo sapiens	183-187
11211609-4	2001	We assessed PS6K dosage in 94 archival paraffin-embedded meningiomas using dual-color fluorescence in situ hybridization.	Paraffin	39-47	ribosomal protein S6 kinase B1	Homo sapiens	12-16
11230701-4	2001	We studied the expression of NCAM in paraffin-embedded human heart tissues from 34 autopsies of patients with Chagas" myocarditis and from murine and canine experimental acute Chagas" myocarditis, using a polyclonal anti-NCAM antibody and immunohistochemistry.	Paraffin	37-45	neural cell adhesion molecule 1	Homo sapiens	29-33
11928895-7	2001	After 48 hours the brain was removed and expression of VEGF studied immunohistochemically on paraffin sections.	Paraffin	93-101	vascular endothelial growth factor A	Rattus norvegicus	55-59
11102971-10	2000	In situ hybridization on paraffin sections showed the cellular localization of CRII-7/rMDC15 mRNA in Schwann cells and endothelial cells of peripheral nerve and in various neuronal populations in brain and spinal cord.	Paraffin	25-33	ADAM metallopeptidase domain 15	Rattus norvegicus	79-85
11102971-10	2000	In situ hybridization on paraffin sections showed the cellular localization of CRII-7/rMDC15 mRNA in Schwann cells and endothelial cells of peripheral nerve and in various neuronal populations in brain and spinal cord.	Paraffin	25-33	ADAM metallopeptidase domain 15	Rattus norvegicus	86-92
11063647-5	2000	METHODS: Immunohistochemisty identification of glycodelin-A was performed on archival paraffin-embedded sections from 10 hysterectomies and 4 cone biopsies.	Paraffin	86-94	progestagen associated endometrial protein	Homo sapiens	47-59
11026105-2	2000	Immunohistochemical analysis of beta-catenin was performed on paraffin-embedded tissue from 30 cases with adenocarcinomas and premalignant lesions.	Paraffin	62-70	catenin beta 1	Homo sapiens	32-44
11012744-10	2000	Neoplastic cells in paraffin-embedded tissue specimens from these patients had CD3(CD3epsilon)+ CD56(123C3)+ granzyme+ TIA-1+ EBERT+ CD43(MT1)- CD45RO(UCHL-1)- CD57(Leu7)- CD20(L26)- phenotypes.	Paraffin	20-28	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	83-93
11012744-10	2000	Neoplastic cells in paraffin-embedded tissue specimens from these patients had CD3(CD3epsilon)+ CD56(123C3)+ granzyme+ TIA-1+ EBERT+ CD43(MT1)- CD45RO(UCHL-1)- CD57(Leu7)- CD20(L26)- phenotypes.	Paraffin	20-28	neural cell adhesion molecule 1	Homo sapiens	96-100
10899449-0	2000	Immunohistochemical staining of dystrophin on formalin-fixed paraffin-embedded sections in Duchenne/Becker muscular dystrophy and manifesting carriers of Duchenne muscular dystrophy.	Paraffin	61-69	dystrophin	Homo sapiens	32-42
10899449-1	2000	We succeeded in immunostaining of monoclonal anti-dystrophin antibodies on formalin-fixed and paraffin-embedded muscle sections from patients with Duchenne muscular dystrophy, patients with Becker muscular dystrophy, and manifesting carriers of Duchenne muscular dystrophy using Catalyzed Signal Amplification(TM) system.	Paraffin	94-102	dystrophin	Homo sapiens	50-60
10929767-2	2000	We examined archival paraffin blocks of samples of squamous cell carcinoma (SCC) in chronic venous leg ulcers previously taken from 23 patients and of chronic noncancerous venous leg ulcers from 35 patients for the presence of human papillomavirus (HPV) DNA.	Paraffin	21-29	serpin family B member 3	Homo sapiens	76-79
10849097-4	2000	In contrast, in paraffin-embedded material substantial loss of TCR zeta-chain was detected in old (&gt; 6 years) tissues.	Paraffin	16-24	CD247 molecule	Homo sapiens	63-77
10849097-6	2000	Storage of paraffin-embedded tissue leads to a rapid and substantial loss of TCR zeta-chain reactivity compared to frozen material of the same HD cases.	Paraffin	11-19	CD247 molecule	Homo sapiens	77-91
10815881-4	2000	We examined the association between MI and expression of hMLH1 mismatch repair protein by immunohistochemical analysis of hMLH1 protein in paraffin-embedded tumors from 64 patients.	Paraffin	139-147	mutL homolog 1	Homo sapiens	57-62
10713670-5	2000	Immunohistochemical analysis of PSCA expression was performed on paraffin-embedded sections from 25 normal tissues, 112 primary prostate cancers and nine prostate cancers metastatic to bone.	Paraffin	65-73	prostate stem cell antigen	Homo sapiens	32-36
10927863-3	2000	Paraffin sections were stained by using monoclonal antibody D07 for p53 protein and PC-10 for PCNA.	Paraffin	0-8	proliferating cell nuclear antigen	Homo sapiens	94-98
10720066-2	2000	In this study, the CRH messenger ribonucleic acid (mRNA) transcripts were demonstrated on paraffin sections using the quantitative in situ hybridization method in 37 of 43 hPCAs, including 17 of 22 microadenomas, 15 of 15 macroadenomas, and 5 of 6 locally invasive adenomas according to Hardy"s classification of pituitary adenomas.	Paraffin	90-98	corticotropin releasing hormone	Homo sapiens	19-22
10746928-4	2000	In the present study, NAT1- and NAT2-specific riboprobes were used in hybridization histochemistry studies to localize NAT1 and NAT2 mRNA sequences in formalin-fixed, paraffin-embedded human tissue sections.	Paraffin	167-175	N-acetyltransferase 1	Homo sapiens	119-123
10649242-2	2000	METHODS: Using immunohistochemistry, the authors investigated FasL expression in sections of formalin fixed, paraffin embedded tissue from 13 EADCA.	Paraffin	109-117	Fas ligand	Homo sapiens	62-66
10623653-0	2000	The paraffin-embedded tissue blot detects PrP(Sc) early in the incubation time in prion diseases.	Paraffin	4-12	prolactin family 7, subfamily d, member 1	Mus musculus	42-45
10623653-3	2000	We developed a new and sensitive technique to detect PrP(Sc) in formalin-fixed and paraffin-embedded tissue, the paraffin-embedded tissue blot (PET blot), and reinvestigated archival brain material from CJD as well as BSE and scrapie.	Paraffin	83-91	prolactin family 7, subfamily d, member 1	Mus musculus	53-56
10618883-7	1999	Cells positive for c-Myc and Max expression in LL were 70.6 +/- 19.8% and 47.3 +/- 32.4%, respectively, determined by immunohistochemical staining using paraffin blocks from 23 cases of childhood LL.	Paraffin	153-161	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	19-24
10598873-4	1999	To screen the in situ expression of FasL in normal human tissues, immunohistochemistry was performed using paraffin-embedded human tissues.	Paraffin	107-115	Fas ligand	Homo sapiens	36-40
10556192-7	1999	CD30L, while expressed by some small lymphocytes, was most often coexpressed by CD30(+) neoplastic large cells, as demonstrated by 2-color immunofluorescence and by immunohistochemistry on paraffin sections.	Paraffin	189-197	TNF superfamily member 8	Homo sapiens	0-5
10541284-4	1999	By immunohistochemistry, both COX-1 and COX-2 were localized to intercalated cells of the CCD on paraffin-embedded mouse kidney sections.	Paraffin	97-105	prostaglandin-endoperoxide synthase 1	Mus musculus	30-35
10446974-12	1999	Single-strand conformational polymorphism analysis of DNA from laser capture microdissected cells of paraffin-embedded AFB1-induced tumor tissue sections stained for p53 produced banding patterns consistent with point mutations in 18 of 30 (60%) DNA samples.	Paraffin	101-109	transformation related protein 53, pseudogene	Mus musculus	166-169
10497849-1	1999	Currently, the immunohistochemical evaluation of cytotoxic granule-associated proteins such as TIA-1 and granzyme B can be carried out on paraffin sections.	Paraffin	138-146	granzyme B	Homo sapiens	105-115
10424893-11	1999	As in tissues, nuclear beta-catenin was detected in paraffin-embedded but not in frozen samples.	Paraffin	52-60	catenin beta 1	Homo sapiens	23-35
10414505-18	1999	The expression of CD56, TIA-1, and EBER-1, in combination, are very useful markers for the diagnosis of nasal NK/T cell lymphoma in paraffin-embedded tissue.	Paraffin	132-140	neural cell adhesion molecule 1	Homo sapiens	18-22
10432006-9	1999	Using immunohistochemical staining, we also examined RAB5A change at protein level in 45 cases human non-small cell lung carcinoma paraffin sections.	Paraffin	131-139	RAB5A, member RAS oncogene family	Homo sapiens	53-58
10494109-7	1999	We have examined regional and cell-type-specific expression of Prx-I and Prx-II in paraffin sections of human brain using immunohistochemical methods.	Paraffin	83-91	peroxiredoxin 1	Homo sapiens	63-68
10188904-2	1999	We have investigated mutation in the PTEN gene by direct sequence analysis of PCR products amplified from samples microdissected from 19 low grade (WHO Grade I and II) and 27 high grade (WHO grade III and IV) archival, formalin-fixed, paraffin-embedded gliomas.	Paraffin	235-243	phosphatase and tensin homolog	Homo sapiens	37-41
9927330-3	1999	Postfixed frozen sections and antigen-retrieved paraffin sections of the ovary revealed nuclear ER beta immunoreactivity (IR) in granulosa cells, which was prevented when peptide-adsorbed antibody was used instead.	Paraffin	48-56	estrogen receptor 2	Rattus norvegicus	96-103
11101284-2	1999	The present study measured the expression of the proto-oncogene Bcl-2 immunohistochemically on paraffin sections of pig ovaries to determine its relationship with folliculogenesis on Days 50 and 80 post coitum (p.c.)	Paraffin	95-103	apoptosis regulator Bcl-2	Sus scrofa	64-69
10629714-5	1999	DNA isolated from paraffin mounts of tumor tissue was used to identify mutations in codon 61 of Ki-ras oncogene.	Paraffin	18-26	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	96-102
9893293-2	1998	Recently, the monoclonal antibodies to PCNA have been used to demonstrate the proliferative component of paraffin-embedded tumor tissues.	Paraffin	105-113	proliferating cell nuclear antigen	Homo sapiens	39-43
9827932-5	1998	Molecular cytogenetic studies of nuclei recovered from paraffin-embedded tissue sections demonstrated that the leukaemic cells contained an MLL translocation.	Paraffin	55-63	lysine methyltransferase 2A	Homo sapiens	140-143
9814501-7	1998	A polyclonal antibody to the carboxyterminus of RET was used for immunohistochemistry on paraffin sections.	Paraffin	89-97	ret proto-oncogene	Homo sapiens	48-51
9666809-0	1998	An increased frequency of numerical chromosomal abnormalities and 1p36 deletions in isolated cells from paraffin sections of malignant melanomas by means of interphase cytogenetics.	Paraffin	104-112	annexin A2	Homo sapiens	67-70
10463282-1	1998	Vimentin is transiently expressed in many cells of neuroectodermal origin in the fetal central nervous system and may be demonstrated by immunohistochemistry in paraffin sections.	Paraffin	161-169	vimentin	Homo sapiens	0-8
9640365-3	1998	To correlate its expression with the histological stage of tumour progression of malignant melanoma (MM), we studied the distribution of CD26/DPP-IV in paraffin sections of a series of 110 benign and malignant pigment-cell lesions of the skin using a cocktail of anti-CD26 monoclonal antibodies and the three-step ABC method.	Paraffin	152-160	dipeptidyl peptidase 4	Homo sapiens	137-141
9610616-3	1998	Polymerase chain reaction (PCR) technology was used to examine the state of amplification of the proto-oncogene c-myc in formalin-fixed paraffin-embedded tissues.	Paraffin	136-144	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	97-117
9699184-4	1998	Expression of spr1 in 63 cases of formalin-fixed and paraffin-embedded human bronchogenic carcinoma was studied by immunohistochemical staining.	Paraffin	53-61	psoriasis susceptibility 1 candidate 2	Homo sapiens	14-18
9762365-2	1998	PCNA expression was studied in odontogenic keratocysts (n = 15) and ameloblastomas (n = 46) using an avidin-biotin-peroxidase complex method on routinely processed paraffin sections.	Paraffin	164-172	proliferating cell nuclear antigen	Homo sapiens	0-4
9472715-0	1998	Immunohistochemical visualization of wild-type p53 protein in paraffin-embedded rat liver using tyramide amplification: zonal hepatic distribution of p53 protein after N-hydroxy-2-acetylaminofluorene administration.	Paraffin	62-70	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	47-50
9472715-7	1998	We have developed a more sensitive immunohistochemical method for staining of p53 in paraffin-embedded sections of rat liver using microwave irradiation for antigen retrieval, avidin-biotin complexing and tyramide amplification.	Paraffin	85-93	Wistar clone pR53P1 p53 pseudogene	Rattus norvegicus	78-81
9621133-2	1998	OBJECTIVE: To study c-myc expression in paraffin-embedded cutaneous melanoma and to correlate to metastatic potential and onset of metastases.	Paraffin	40-48	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	20-25
9522220-1	1998	AIMS: To study the expression of the epithelial adhesion molecule E-cadherin and its associated proteins alpha and beta catenin in paraffin sections of normal ovaries, benign cystadenomas and ovarian carcinomas, and in immortalized normal ovarian surface epithelial cells and ovarian carcinoma cells in culture.	Paraffin	131-139	catenin beta 1	Homo sapiens	115-127
10682555-1	1998	To study the relationship between the expressions of tumor supressor protein p21 and p53 and malignant growth of gastric carcinoma, 88 paraffin embedded specimens of gastric carcinoma and gastric ulcer were examined with immunohistochemical method.	Paraffin	135-143	H3 histone pseudogene 16	Homo sapiens	77-80
9578731-7	1998	PCNA expressing tumor cells is a method of evaluation of proliferative activity in tissues which permits using archival paraffin samples.	Paraffin	120-128	proliferating cell nuclear antigen	Homo sapiens	0-4
9389770-8	1997	Using this optimized ImmunoMax method, we were able to detect CD2, CD3, CD4, and CD5 with conventional monoclonal antibodies in formalin-fixed, paraffin-embedded tissue specimens of various lymphoid tissues.	Paraffin	144-152	CD2 molecule	Homo sapiens	62-65
9389770-8	1997	Using this optimized ImmunoMax method, we were able to detect CD2, CD3, CD4, and CD5 with conventional monoclonal antibodies in formalin-fixed, paraffin-embedded tissue specimens of various lymphoid tissues.	Paraffin	144-152	CD5 molecule	Homo sapiens	81-84
9236923-7	1997	METHODS: Expression of p53 and PCNA were detected by immunocytochemistry in paraffin-embedded sections of infiltrating duct carcinoma and control breast tissue (normal tissue and adenoma).	Paraffin	76-84	proliferating cell nuclear antigen	Homo sapiens	31-35
11038767-2	1997	METHODS: p21 H-ras expression and H-ras codon 12 mutation was detected in the same paraffin embedded tissues of 171 cases of cervical carcinoma, 68 cases of SIL, and 29 cases of chronic cervicitis, by using immunohistochemical and PCR-RFLP techniques.	Paraffin	83-91	H3 histone pseudogene 16	Homo sapiens	9-12
11038767-2	1997	METHODS: p21 H-ras expression and H-ras codon 12 mutation was detected in the same paraffin embedded tissues of 171 cases of cervical carcinoma, 68 cases of SIL, and 29 cases of chronic cervicitis, by using immunohistochemical and PCR-RFLP techniques.	Paraffin	83-91	HRas proto-oncogene, GTPase	Homo sapiens	13-18
11038767-2	1997	METHODS: p21 H-ras expression and H-ras codon 12 mutation was detected in the same paraffin embedded tissues of 171 cases of cervical carcinoma, 68 cases of SIL, and 29 cases of chronic cervicitis, by using immunohistochemical and PCR-RFLP techniques.	Paraffin	83-91	HRas proto-oncogene, GTPase	Homo sapiens	34-39
9214598-2	1997	Analysis by PCR amplification and allele-specific hybridization (ASO) of paraffin-embedded tumors generated from that study revealed the presence of point mutations in exon 1 of the Ki-ras gene.	Paraffin	73-81	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	182-188
9216712-4	1997	We examined the expression of PSA employing a biotin-streptavidin based, alkaline phosphatase conjugated antigen detection technique in routine, neutral formalin fixed, paraffin-wax embedded, 3-4 microns thick tissue sections of 30 CMMs and 10 MMMs.	Paraffin	169-181	kallikrein related peptidase 3	Homo sapiens	30-33
9075637-0	1997	Improved immunohistochemical staining of osteopontin (OPN) in paraffin-embedded archival bone specimens following antigen retrieval: anti-human OPN antibody recognizes multiple molecular forms.	Paraffin	62-70	secreted phosphoprotein 1	Homo sapiens	41-52
9075637-0	1997	Improved immunohistochemical staining of osteopontin (OPN) in paraffin-embedded archival bone specimens following antigen retrieval: anti-human OPN antibody recognizes multiple molecular forms.	Paraffin	62-70	secreted phosphoprotein 1	Homo sapiens	54-57
9111215-5	1997	Mutations in K-ras and H-ras were identified by single-strand conformational analysis and direct sequencing of polymerase chain reaction (PCR) amplified DNA, isolated from paraffin-embedded sections of HG neoplasms.	Paraffin	172-180	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	13-18
9138112-1	1997	The expression of c-myc protein was studied in formalin-fixed, paraffin-embedded sections of 16 compound Spitz nevi (SNs), 20 ordinary compound melanocytic nevi (MNs) and 30 malignant melanomas (MMs), using monoclonal antibody 9E10 and an immunoperoxidase technique.	Paraffin	63-71	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
9350310-3	1997	In the present paper, we have studied anti-PCNA antibody PC10 in supraglottic cancer by means of immunohistochemistry using paraffin-embedded sections, to demonstrate its clinical significance in this type of malignancy.	Paraffin	124-132	proliferating cell nuclear antigen	Homo sapiens	43-47
9352386-7	1997	Immunohistochemistry was performed on various fresh and paraffin-embedded tissues and apolipoprotein H was immunolocalized in the cytoplasm of hepatocytes and epithelial cells from colon and jejunum.	Paraffin	56-64	apolipoprotein H	Homo sapiens	86-102
8989925-0	1997	Detection of thymidylate synthase gene expression levels in formalin-fixed paraffin embedded tissue by semiquantitative, nonradioactive reverse transcriptase polymerase chain reaction.	Paraffin	75-83	thymidylate synthetase	Homo sapiens	13-33
8989925-2	1997	To evaluate the experimental conditions, we examined thymidylate synthase (TS) gene expression in mRNA isolated from both flash-frozen and formalin-fixed paraffin-embedded human biopsy samples using biopsy material obtained from 2 patients prior to chemotherapy with 5-fluorouracil.	Paraffin	154-162	thymidylate synthetase	Homo sapiens	75-77
9032976-0	1997	An improved method to detect beta-galactosidase activity in transgenic mice: a post-staining procedure on paraffin embedded tissue sections.	Paraffin	106-114	galactosidase, beta 1	Mus musculus	29-47
9032976-2	1997	Here we report a procedure for monitoring beta-galactosidase activity directly in tissue sections, which involves the use of a mixture of ethanol and poly-ethylene-glycol as a fixative (Kryofix) and a special paraffin characterized by a lower fusion point of 42 degrees C. After embedding and cutting, the sections are stained by the chromogenic substrate 5-bromo-4-chloro-3-indoyl-beta-D galactopyranoside (X-Gal).	Paraffin	209-217	galactosidase, beta 1	Mus musculus	42-60
8957552-1	1996	A rapid enhanced polymer one-step staining for proliferating cell nuclear antigen (EPOS-PCNA) in formalin fixed, paraffin embedded sections of tongue squamous cell carcinoma is described.	Paraffin	113-121	proliferating cell nuclear antigen	Homo sapiens	47-81
8957552-1	1996	A rapid enhanced polymer one-step staining for proliferating cell nuclear antigen (EPOS-PCNA) in formalin fixed, paraffin embedded sections of tongue squamous cell carcinoma is described.	Paraffin	113-121	proliferating cell nuclear antigen	Homo sapiens	83-92
8853036-0	1996	CD5 immunoreactivity of epithelial cells in thymic carcinoma and CASTLE using paraffin-embedded tissue.	Paraffin	78-86	CD5 molecule	Homo sapiens	0-3
8853036-8	1996	CD5 labels some thymic carcinomas in paraffin-embedded tissue, whereas other tumors studied were negative.	Paraffin	37-45	CD5 molecule	Homo sapiens	0-3
8780389-6	1996	This sensitive method allows the detection of Pgp in capillary endothelial cells of normal brain in conventional paraffin sections after formalin fixation.	Paraffin	113-121	phosphoglycolate phosphatase	Homo sapiens	46-49
21541548-2	1996	We therefore evaluated the prognostic tool of PCNA antigen expression on paraffin-embedded sections of 54 patients with hepatocellular carcinoma and concomitant cirrhosis.	Paraffin	73-81	proliferating cell nuclear antigen	Homo sapiens	46-50
8754651-3	1996	In the present study, 58 cases of invasive breast carcinomas were tested for vimentin on formaldehyde fixed paraffin embedded sections.	Paraffin	108-116	vimentin	Homo sapiens	77-85
8794404-4	1996	We also evaluated the effect of microwave pre-treatment of formalin-fixed, paraffin-embedded sections on the NCAM immunostaining and related the outcome to the postoperative clinical course of disease.	Paraffin	75-83	neural cell adhesion molecule 1	Homo sapiens	109-113
8636375-11	1996	H19 imprinting was maintained in all 18 informative fresh-frozen and paraffin-embedded formalin-fixed samples.	Paraffin	69-77	H19 imprinted maternally expressed transcript	Homo sapiens	0-3
8600060-1	1996	Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases.	Paraffin	92-100	proliferating cell nuclear antigen	Homo sapiens	0-34
8600060-1	1996	Proliferating cell nuclear antigen (PCNA) expression was studied by immunohistochemistry on paraffin-embedded sections of 293 primary colorectal adenocarcinomas and 56 corresponding lymph node metastases.	Paraffin	92-100	proliferating cell nuclear antigen	Homo sapiens	36-40
8762435-1	1996	The reexpression of nerve growth factor receptor (NGFR) on paraffin sections of the human spinal cord was examined with immunohistochemical method in 18 cases with survival periods from 2 hours to 28 months after a traumatic injury.	Paraffin	59-67	nerve growth factor receptor	Homo sapiens	20-48
8762435-1	1996	The reexpression of nerve growth factor receptor (NGFR) on paraffin sections of the human spinal cord was examined with immunohistochemical method in 18 cases with survival periods from 2 hours to 28 months after a traumatic injury.	Paraffin	59-67	nerve growth factor receptor	Homo sapiens	50-54
8850240-0	1995	[Diagnostic and prognostic value of the immunohistochemical study of proliferating cell nuclear antigen (PCNA) expression in paraffin sections from non-hodgkin"s lymphoma].	Paraffin	125-133	proliferating cell nuclear antigen	Homo sapiens	69-103
8850240-0	1995	[Diagnostic and prognostic value of the immunohistochemical study of proliferating cell nuclear antigen (PCNA) expression in paraffin sections from non-hodgkin"s lymphoma].	Paraffin	125-133	proliferating cell nuclear antigen	Homo sapiens	105-109
8697990-7	1995	Immunohistochemistry (ABC method) on section of paraffin embedded tissue is a reliable method for detecting c-myc and p53 gene expression in HCC.	Paraffin	48-56	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	108-113
7614698-7	1995	K-ras mutations were detected by single-strand conformation analysis and identified by direct sequencing of polymerase chain reaction-amplified DNA isolated from formalin-fixed, paraffin-embedded neoplasms.	Paraffin	178-186	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-5
7555254-1	1995	In this study, the reexpression of nerve growth factor receptor (NGFR) on paraffin sections of the human spinal cord was examined with immunohistochemical method in 18 cases with survival periods of 2 hours to 28 months after trauma.	Paraffin	74-82	nerve growth factor receptor	Homo sapiens	35-63
7555254-1	1995	In this study, the reexpression of nerve growth factor receptor (NGFR) on paraffin sections of the human spinal cord was examined with immunohistochemical method in 18 cases with survival periods of 2 hours to 28 months after trauma.	Paraffin	74-82	nerve growth factor receptor	Homo sapiens	65-69
7532156-1	1995	We used an immunohistochemical assay with an antigen-retrieval technique to study plasminogen activator inhibitor type-1 (PAI-1) expression in paraffin-embedded breast tissue samples at different stages of malignant transformation.	Paraffin	143-151	serpin family E member 1	Homo sapiens	82-120
7532156-1	1995	We used an immunohistochemical assay with an antigen-retrieval technique to study plasminogen activator inhibitor type-1 (PAI-1) expression in paraffin-embedded breast tissue samples at different stages of malignant transformation.	Paraffin	143-151	serpin family E member 1	Homo sapiens	122-127
7548788-5	1995	The aim of this study was to detect and localize the immunohistochemical expression of P-gp in normal and neoplastic gastrointestinal tissue using the Mab JSB-1 in formalin-fixed paraffin-embedded specimens.	Paraffin	179-187	phosphoglycolate phosphatase	Homo sapiens	87-91
7567689-1	1995	An antibody to the ret proto-oncogene product (RET) was raised and applied to formalin-fixed, paraffin-embedded neuroblastic tumors (NBTs) to investigate its usefulness in diagnosis and evaluation of cell differentiation.	Paraffin	94-102	ret proto-oncogene	Homo sapiens	19-22
7567689-1	1995	An antibody to the ret proto-oncogene product (RET) was raised and applied to formalin-fixed, paraffin-embedded neuroblastic tumors (NBTs) to investigate its usefulness in diagnosis and evaluation of cell differentiation.	Paraffin	94-102	ret proto-oncogene	Homo sapiens	47-50
7859359-5	1995	Paraffin embedded tissue sections were hybridized with a digoxigenin-labeled 39 base oligomer, antisense to 8-oxo-dGTPase cDNA.	Paraffin	0-8	nudix hydrolase 1	Homo sapiens	108-121
7777480-1	1995	Proliferating cell nuclear antigen (PCNA), an auxiliary protein of DNA polymerase-delta, has recently been proposed as a marker of proliferation that is detectable in formalin-fixed paraffin-embedded tissue.	Paraffin	182-190	proliferating cell nuclear antigen	Homo sapiens	0-34
7777480-1	1995	Proliferating cell nuclear antigen (PCNA), an auxiliary protein of DNA polymerase-delta, has recently been proposed as a marker of proliferation that is detectable in formalin-fixed paraffin-embedded tissue.	Paraffin	182-190	proliferating cell nuclear antigen	Homo sapiens	36-40
7777480-3	1995	In this study, we investigate the relationship between formalin fixation time and immunoreactivity for PCNA in paraffin-embedded sections and examine the effect of postfixation tissue treatment with modified Bouin"s solution.	Paraffin	111-119	proliferating cell nuclear antigen	Homo sapiens	103-107
7579511-1	1995	Immunostaining for heat-shock protein-27 (HSP-27) was performed on formalin fixed-paraffin embedded sections of 890 node-positive breast carcinomas resected between 1980 and 1986.	Paraffin	82-90	heat shock protein family B (small) member 1	Homo sapiens	42-48
7927945-5	1994	We used PC10, a monoclonal antibody (MAb) directed against PCNA, which allows cell proliferation in formalin-fixed, paraffin-embedded tumor tissue to be evaluated.	Paraffin	116-124	proliferating cell nuclear antigen	Homo sapiens	59-63
7943181-0	1994	Detection of RET proto-oncogene point mutations in paraffin-embedded pheochromocytoma specimens by nonradioactive single-strand conformation polymorphism analysis and direct sequencing.	Paraffin	51-59	ret proto-oncogene	Homo sapiens	13-16
7835840-2	1994	The expression of PCNA (PC10 score) was examined immunohistochemically using the monoclonal antibody PC10 on paraffin sections from 45 cases.	Paraffin	109-117	proliferating cell nuclear antigen	Homo sapiens	18-22
7868360-0	1994	Computer-aided image analysis applied to immunogold-silver staining: evaluation of proliferating cell nuclear antigen (PCNA)-reactive sites in paraffin sections.	Paraffin	143-151	proliferating cell nuclear antigen	Homo sapiens	83-117
7868360-0	1994	Computer-aided image analysis applied to immunogold-silver staining: evaluation of proliferating cell nuclear antigen (PCNA)-reactive sites in paraffin sections.	Paraffin	143-151	proliferating cell nuclear antigen	Homo sapiens	119-123
8137214-4	1994	METHODS: The presence of PTHrp in SCC has been studied by immunohistochemistry in formalin fixed, paraffin embedded tissues.	Paraffin	98-106	serpin family B member 3	Homo sapiens	34-37
8086630-1	1994	Expression of c-myc oncogene transcripts in colorectal neoplasia was studied in paraffin embedded tissue sections from 25 patients undergoing surgery and from the rectal carcinoma cell line HR-8348 by using in situ hybridization, and its amplification was investigated in tumor and normal mucosa tissue from 25 coloproctomy samples by slot blot hybridization.	Paraffin	80-88	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	14-19
7828605-3	1994	In the present paper the immunohistochemical expression of p185, p21 and proliferating cell nuclear antigen (PCNA) was retrospectively assessed in formalin-fixed, paraffin-embedded tissue samples taken from 28 primary ovarian carcinomas at first surgery.	Paraffin	163-171	proliferating cell nuclear antigen	Homo sapiens	109-113
7909152-6	1994	Local recurrence and/or mortality were ascertained with a minimum follow-up of 5 yr. An immunohistochemical assay for PCNA was performed on a paraffin section of tumor and the percentage of positively stained cells ("PCNA index") was determined.	Paraffin	142-150	proliferating cell nuclear antigen	Homo sapiens	118-122
7529427-12	1994	Reduced PCNA antigenicity in archival, formalin-fixed, paraffin-embedded bladder tumour tissue was observed.	Paraffin	55-63	proliferating cell nuclear antigen	Homo sapiens	8-12
8221692-5	1993	To overcome this problem paraffin-embedded material must be made amenable for determination of HMG-I(Y) expression in retrospective studies.	Paraffin	25-33	high mobility group AT-hook 1	Homo sapiens	95-103
8259594-4	1993	Twenty-percent chloroform (wt/wt) and a dithizone concentration of 5.0 x 10(-5) M combined in paraffin (TP-2) produced optimal color change from pink to green after &gt; 1500 cGy.	Paraffin	94-102	transition protein 2	Homo sapiens	104-108
7904841-2	1993	Immunostaining with the monoclonal antibody PC10 binding to proliferating cell nuclear antigen (PCNA) facilitates the assessment of proliferation in routinely fixed, paraffin-embedded tissue sections.	Paraffin	166-174	proliferating cell nuclear antigen	Homo sapiens	60-94
7904841-2	1993	Immunostaining with the monoclonal antibody PC10 binding to proliferating cell nuclear antigen (PCNA) facilitates the assessment of proliferation in routinely fixed, paraffin-embedded tissue sections.	Paraffin	166-174	proliferating cell nuclear antigen	Homo sapiens	96-100
8102513-3	1993	PCNA is a nuclear protein maximally elevated in the S phase of the cell cycle and recognized immunohistochemically in paraffin sections by the monoclonal antibody PC-10.	Paraffin	118-126	proliferating cell nuclear antigen	Homo sapiens	0-4
8103785-2	1993	The results were as follows: 1) The immunohistochemical study of PCNA was useful as a marker to detect proliferating activity in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	145-153	proliferating cell nuclear antigen	Homo sapiens	65-69
8105131-1	1993	Proliferating cell nuclear antigen (PCNA) of formalin-fixed, paraffin-embedded bladder cancer section was identified by immunohistochemistry in 42 bladder cancer patients.	Paraffin	61-69	proliferating cell nuclear antigen	Homo sapiens	0-34
8105131-1	1993	Proliferating cell nuclear antigen (PCNA) of formalin-fixed, paraffin-embedded bladder cancer section was identified by immunohistochemistry in 42 bladder cancer patients.	Paraffin	61-69	proliferating cell nuclear antigen	Homo sapiens	36-40
8105885-4	1993	Anti-PCNA monoclonal antibody was applied to paraffin sections to identify proliferating cells by the SAB technique.	Paraffin	45-53	proliferating cell nuclear antigen	Homo sapiens	5-9
8398092-4	1993	We have studied the HLA class I expression by the cells in premalignant epithelial lesions and invasive carcinoma of the bladder and uterine cervix using immunoperoxidase staining for beta 2-microglobulin of paraffin-embedded tissue.	Paraffin	208-216	beta-2-microglobulin	Homo sapiens	184-204
8331897-3	1993	EXPERIMENTAL DESIGN: We have developed an immunofluorescence in situ hybridization assay suitable for detection of MYCN amplification and 1p deletion in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	169-177	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	115-119
8103531-3	1993	Contrary to Ki-67, PCNA antibody can be applied on aldehyde- or alcohol-fixed and paraffin-embedded tissues, thus allowing studies on archival material.	Paraffin	82-90	proliferating cell nuclear antigen	Homo sapiens	19-23
8093131-4	1993	Immunostaining of paraffin-embedded sections proved tumor cells to be positive for T-cell markers MT1 and UCHL1, and negative for B-cell markers MB1, and 4KB5.	Paraffin	18-26	metallothionein 1I, pseudogene	Homo sapiens	98-101
8093131-4	1993	Immunostaining of paraffin-embedded sections proved tumor cells to be positive for T-cell markers MT1 and UCHL1, and negative for B-cell markers MB1, and 4KB5.	Paraffin	18-26	ubiquitin C-terminal hydrolase L1	Homo sapiens	106-111
7684194-6	1993	In 957 routinely fixed, paraffin-embedded samples, PG-M1 showed a more restricted reactivity with elements of the monocyte/macrophage lineage than the previously described monoclonal antibodies MAC-387 (anti-calgranulins), KP1 (CD68) and Ki-M1P.	Paraffin	24-32	phosphoglucomutase 1	Homo sapiens	51-56
7684194-9	1993	In the daily diagnostic practice, PG-M1 seems to be particularly valuable for the diagnosis of myelomonocytic or monocytic leukemia and neoplasms of true histiocytic origin in routine paraffin sections.	Paraffin	184-192	phosphoglucomutase 1	Homo sapiens	34-39
8468458-7	1993	These results show that an anti-rat UCP antibody can be used for immunohistochemical detection of UCP in human brown adipose tissue and that it provides a useful method for distinguishing between white and brown fat in paraffin-embedded samples.	Paraffin	219-227	uncoupling protein 1	Homo sapiens	36-39
7682759-0	1993	Proliferating cell nuclear antigen immunohistochemistry using monoclonal antibody 19A2 and a new antigen retrieval technique has prognostic impact in archival paraffin-embedded node-negative breast cancer.	Paraffin	159-167	proliferating cell nuclear antigen	Homo sapiens	0-34
7682759-9	1993	In conclusion, PCNA immunohistochemistry with the 19A2 antibody after an appropriate antigen retrieval treatment may offer a useful alternative to DNA flow cytometry for the analysis of cell proliferation activity from formalin-fixed, paraffin-embedded breast carcinomas.	Paraffin	235-243	proliferating cell nuclear antigen	Homo sapiens	15-19
7681701-1	1993	Two anti-nerve growth factor receptor (LNGFR or p75NGFR) antibodies, Me20.4 and Me8211, label stromal cells with dendritic features in fresh smears and in formalin-fixed, paraffin-embedded human bone marrow (BM).	Paraffin	171-179	nerve growth factor receptor	Homo sapiens	9-37
7682888-2	1993	In a case of endometrioid carcinoma of the prostate the expression of Leu7 and prostatic specific antigen (PSA) was studied immunohistochemically on paraffin sections.	Paraffin	149-157	aminopeptidase puromycin sensitive	Homo sapiens	79-111
8422109-1	1993	Expression of Proliferating cell nuclear antigen (PCNA) was evaluated in formalin-fixed, paraffin-embedded normal and abnormal cervical squamous epithelia using immunoperoxidase stains and PC10 monoclonal antibody to PCNA.	Paraffin	89-97	proliferating cell nuclear antigen	Homo sapiens	14-48
8422109-1	1993	Expression of Proliferating cell nuclear antigen (PCNA) was evaluated in formalin-fixed, paraffin-embedded normal and abnormal cervical squamous epithelia using immunoperoxidase stains and PC10 monoclonal antibody to PCNA.	Paraffin	89-97	proliferating cell nuclear antigen	Homo sapiens	50-54
7910087-5	1993	Both PCNA and DNA analysis can be performed on histological sections from paraffin embedded biopsies.	Paraffin	74-82	proliferating cell nuclear antigen	Homo sapiens	5-9
8098331-1	1993	We investigated the expression of proliferating cell nuclear antigen (PCNA) in paraffin sections from 20 cases of medullary thyroid carcinoma (MTC).	Paraffin	79-87	proliferating cell nuclear antigen	Homo sapiens	34-68
8098331-1	1993	We investigated the expression of proliferating cell nuclear antigen (PCNA) in paraffin sections from 20 cases of medullary thyroid carcinoma (MTC).	Paraffin	79-87	proliferating cell nuclear antigen	Homo sapiens	70-74
8509440-0	1993	Immunoblot analysis of the placental form of glutathione S-transferase in protein extracted from paraffin-embedded human glioma tissue.	Paraffin	97-105	glutathione S-transferase kappa 1	Homo sapiens	45-70
7901939-1	1993	The expression of the S-phase associated, nuclear protein proliferating cell nuclear antigen (PCNA) was investigated in routinely paraffin-embedded surgical specimens from 209 breast cancer patients.	Paraffin	130-138	proliferating cell nuclear antigen	Homo sapiens	58-92
7901939-1	1993	The expression of the S-phase associated, nuclear protein proliferating cell nuclear antigen (PCNA) was investigated in routinely paraffin-embedded surgical specimens from 209 breast cancer patients.	Paraffin	130-138	proliferating cell nuclear antigen	Homo sapiens	94-98
7906909-1	1993	The expression of proliferating cell nuclear antigen (PCNA) was examined in formalin-fixed paraffin-embedded tissue sections from 41 lesions (27 melanocytic nevi, 3 atypical nevi and 11 malignant melanomas) to determine the proliferative activity of primary cutaneous melanocytic tumours.	Paraffin	91-99	proliferating cell nuclear antigen	Homo sapiens	18-52
7906909-1	1993	The expression of proliferating cell nuclear antigen (PCNA) was examined in formalin-fixed paraffin-embedded tissue sections from 41 lesions (27 melanocytic nevi, 3 atypical nevi and 11 malignant melanomas) to determine the proliferative activity of primary cutaneous melanocytic tumours.	Paraffin	91-99	proliferating cell nuclear antigen	Homo sapiens	54-58
1355398-0	1992	The expression of proliferating cell nuclear antigen in paraffin sections of peripheral, node-negative non-small cell lung cancer.	Paraffin	56-64	proliferating cell nuclear antigen	Homo sapiens	18-52
1355398-12	1992	It was concluded that PCNA immunostaining is a simple and clinically useful method for estimating cell proliferation in formalin-fixed, paraffin-embedded tissue of resected peripheral, node-negative NSCLC.	Paraffin	136-144	proliferating cell nuclear antigen	Homo sapiens	22-26
1354677-2	1992	Our goal was to provide guidelines for PCNA immunohistochemistry in formalin-fixed, paraffin-embedded specimens.	Paraffin	84-92	proliferating cell nuclear antigen	Homo sapiens	39-43
1374093-3	1992	The MAb were used in immunohistology to demonstrate the L-PK isoenzyme in paraffin-embedded normal rat tissues.	Paraffin	74-82	pyruvate kinase L/R	Rattus norvegicus	56-60
1583889-3	1992	The efficiency of detecting K-ras mutations was similar for sequencing of amplified fragments derived from both paraffin-embedded tissues and from frozen tumors.	Paraffin	112-120	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	28-33
1583889-6	1992	Direct sequencing of PCR products from paraffin-embedded sections was more sensitive than NIH 3T3 transfection for detection of activated K-ras genes containing codon 13 mutations but less sensitive for detection of activated H-ras genes containing codon 61 mutations.	Paraffin	39-47	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	138-143
1583889-7	1992	In summary, direct sequencing of amplified DNA from either frozen tumors or formalin-fixed, paraffin-embedded tissues can be more sensitive than NIH 3T3 transfection for detection of codon 13-activated K-ras genes.	Paraffin	92-100	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	202-207
1347557-1	1992	We have investigated whether monoclonal antibody (PC10) of proliferating cell nuclear antigen (PCNA) could be useful as a marker of proliferating cells within formalin-fixed, paraffin-embedded tissue sections of 140 gynecological tumors and their related lesions.	Paraffin	175-183	proliferating cell nuclear antigen	Homo sapiens	59-93
16668669-1	1992	The distribution of napin and cruciferin, the two major storage proteins in rape seed, Brassica napus, has been visualized during seed development by antibody staining of paraffin-embedded and sectioned seeds.	Paraffin	171-179	napin	Brassica napus	20-25
1733441-1	1992	Immunocytochemistry with monoclonal antibody Y13-259 demonstrated p21 ras in paraffin sections of breast tissue from 171 women: 85 with invasive breast carcinoma, 14 with non-invasive carcinoma and 72 with benign changes only.	Paraffin	77-85	H3 histone pseudogene 16	Homo sapiens	66-69
1760355-1	1991	This study demonstrated that in-situ hybridization using digoxigenin-labelled oligonucleotide poly-T probes and digoxigenin-labelled riboprobes for keratin 14 is possible on routinely fixed paraffin-embedded sections.	Paraffin	190-198	keratin 14	Homo sapiens	148-158
1719072-3	1991	We have developed and optimized a dinitrophenyl hapten sandwich staining (DHSS) immunocytochemical procedure to demonstrate ER in paraffin-embedded, hormone-sensitive tissues of the rat and in human breast cancers.	Paraffin	130-138	estrogen receptor 1	Rattus norvegicus	124-126
1719072-7	1991	This highly sensitive method localized the ER within paraffin-embedded rat uterus, fallopian tube, vagina, and normal and cancerous mammary gland.	Paraffin	53-61	estrogen receptor 1	Rattus norvegicus	43-45
1712546-0	1991	Aberrant MT2 positivity distinguishes follicular lymphoma from reactive follicular hyperplasia in B5- and formalin-fixed paraffin sections.	Paraffin	121-129	metallothionein 2A	Homo sapiens	9-12
1746900-1	1991	In the present work, we studied the expression of the c-myc oncoprotein p-62 and the ras oncoprotein p-21 in the dermal cellular infiltrate of paraffin embedded skin specimens, obtained from patients suffering from Mycosis Fungoides and Sezary syndrome.	Paraffin	143-151	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	54-59
1746900-1	1991	In the present work, we studied the expression of the c-myc oncoprotein p-62 and the ras oncoprotein p-21 in the dermal cellular infiltrate of paraffin embedded skin specimens, obtained from patients suffering from Mycosis Fungoides and Sezary syndrome.	Paraffin	143-151	H3 histone pseudogene 16	Homo sapiens	101-105
1653038-0	1991	In situ hybridization for the detection of feline interleukin 1 alpha mRNA on the paraffin-embedded section using biotin-labeled probes.	Paraffin	82-90	interleukin 1 alpha	Homo sapiens	50-69
1653038-3	1991	Hence, we tried by this biotinylated probe to detect mRNA of IL-1 alpha in paraffin-embedded sections.	Paraffin	75-83	interleukin 1 alpha	Homo sapiens	61-71
1961011-1	1991	In the past the fixation procedures employed in the immunohistostaining of paraffin-embedded tissues with anti-myc protein antibodies were unsatisfactory since they permitted the leakage of the protein from its normal nuclear localization in the cell.	Paraffin	75-83	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	111-114
1981239-0	1990	Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms.	Paraffin	64-72	proliferating cell nuclear antigen	Homo sapiens	0-34
1981239-0	1990	Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin sections: an index of cell proliferation with evidence of deregulated expression in some neoplasms.	Paraffin	64-72	proliferating cell nuclear antigen	Homo sapiens	36-40
1979976-2	1990	The analysis was achieved by successful immunohistochemical demonstration of proliferating cell nuclear antigen in formalin-fixed paraffin-embedded tissue sections.	Paraffin	130-138	proliferating cell nuclear antigen	Homo sapiens	77-111
2334139-4	1990	Mabs 5D10, 2B4, and 3B7 recognize the same antigen (MW 80,000-90,000) in fresh tissue and in paraffin embedded sections.	Paraffin	93-101	CD244 molecule	Homo sapiens	11-14
1703068-0	1990	Reproducibility of FCM DNA content from replicate paraffin block samples.	Paraffin	50-58	nucleolar protein 3	Homo sapiens	19-22
2101132-0	1990	Immunohistochemical detection of c-myc oncoprotein in paraffin embedded tissues.	Paraffin	54-62	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	33-38
2101132-1	1990	In almost all studies using paraffin embedded tissue, c-myc protein has been found in the cytoplasm of cells.	Paraffin	28-36	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	54-59
2101132-7	1990	Our data strongly suggest that AMeX fixation, originally developed for T and B lymphocyte antigens, should be used for immunolocalization of c-myc oncoprotein in paraffin embedded tissues.	Paraffin	162-170	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	141-146
2311095-4	1990	The optimal condition of desmin mRNA detection was in cryostat sections fixed with paraformaldehyde and in paraffin embedded tissue with the same fixative.	Paraffin	107-115	desmin	Homo sapiens	25-31
27463992-1	1990	The expression of c-myc oncogene in neoplastic and non-neoplastic lymphoid tissue was studied using the specific monoclonal antibody myc 1-9E10 and the 3 step streptavidin-biotin immunoperoxidase method in paraffin sections.	Paraffin	206-214	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	18-23
33819809-2	2021	MATERIALS AND METHODS: The association between EBV infection and expression of indoleamine 2,3-dioxygenase (IDO) was assessed in 165 paraffin-embedded oral squamous cell carcinoma (OSCC) tissue samples.	Paraffin	133-141	indoleamine 2,3-dioxygenase	None	79-106
33819809-2	2021	MATERIALS AND METHODS: The association between EBV infection and expression of indoleamine 2,3-dioxygenase (IDO) was assessed in 165 paraffin-embedded oral squamous cell carcinoma (OSCC) tissue samples.	Paraffin	133-141	indoleamine 2,3-dioxygenase 1	Homo sapiens	108-111
34953041-7	2022	PD-L1 expression was highly consistent in different paraffin blocks of the same surgically resected specimen (concordance rate: 86.5%, p = 0.000016) and a moderate consistency (concordance rate: 78.0%, p = 0.000373) for the primary and metastatic lymph node lesion comparison.	Paraffin	52-60	CD274 molecule	Homo sapiens	0-5
34884678-6	2021	The methylation profiles of LEP were measured in 63 formalin-fixed, paraffin-embedded tumor tissues by quantitative polymerase chain reaction using a MethyLight assay.	Paraffin	68-76	leptin	Homo sapiens	28-31
34422362-10	2021	PD-L1 expression differed between different paraffin blocks from the same resected specimen (discordance rate =35.8%, 19/53), and the discordance rate of PD-L1 expression between primary tumours and matched lymph node metastases was 28.6% (14/49).	Paraffin	44-52	CD274 molecule	Homo sapiens	0-5
34206205-4	2021	METHODS: We compared PD-L1 expression in patient-matched frozen (FR) and formalin-fixed paraffin-embedded (FFPE) tissues of breast cancer patients.	Paraffin	88-96	CD274 molecule	Homo sapiens	21-26
34078054-12	2021	The immunohistochemical analyses of 139 formalin fixed paraffin-embedded samples showed that the low expression of BUB1B was correlated with poor prognosis in TNBC (HR=0.41, 95%CI (0.18-0.95), P=0.024).	Paraffin	55-63	BUB1 mitotic checkpoint serine/threonine kinase B	Homo sapiens	115-120
34337305-7	2021	Paraffin sections of tumor tissues were stained immunohistochemically using TM antibody.	Paraffin	0-8	thrombomodulin	Homo sapiens	76-78
35598375-4	2022	Immunohistochemical (IHC) analysis of 114 paraffin-embedded archived ESCC tissues demonstrated that COL3A1 expression was positively correlated with the postoperative T stage.	Paraffin	42-50	collagen type III alpha 1 chain	Homo sapiens	100-106
35439652-3	2022	In this study we aim to evaluate and validate the utility and reliability of the TERT RNAscope  in-situ hybridization (ISH) assay for the detection of TERT mRNA expression in formalin-fixed, paraffin embedded tissue.	Paraffin	191-199	telomerase reverse transcriptase	Homo sapiens	81-85
35439652-3	2022	In this study we aim to evaluate and validate the utility and reliability of the TERT RNAscope  in-situ hybridization (ISH) assay for the detection of TERT mRNA expression in formalin-fixed, paraffin embedded tissue.	Paraffin	191-199	telomerase reverse transcriptase	Homo sapiens	151-155
35562908-2	2022	High tumor PD-L1 expression, detected by immunohistochemistry (IHC) typically on formalin-fixed paraffin-embedded (FFPE) histological specimens, is linked to better response.	Paraffin	96-104	CD274 molecule	Homo sapiens	11-16
35255858-4	2022	TSP2 expression levels were analysed in paraffin-embedded GC samples and adjacent normal tissues by immunohistochemistry.	Paraffin	40-48	thrombospondin 2	Homo sapiens	0-4
34984861-4	2022	METHODS: Fluorescence in situ hybridization (FISH) was performed on formalin-fixed paraffin-embedded specimens (FFPE) to examine mouse double minute 2 homolog (MDM2) amplification in all cases.	Paraffin	83-91	transformed mouse 3T3 cell double minute 2	Mus musculus	160-164
34232949-10	2022	Whole-exome sequencing analysis and RNA-seq results of formalin-fixed and paraffin-embedded tissue revealed nine mutant genes (AHNAK2, BFSP1, BRAF, CNTNAP3, DNHD1, MTOR, NFATC3, NOM1).	Paraffin	74-82	AHNAK nucleoprotein 2	Homo sapiens	127-133
34128111-6	2021	In this report, we described a novel droplet digital PCR (ddPCR) assay to evaluate TERT hot spot mutations in fresh frozen and formalin-fixed paraffin-embedded (FFPE) specimens of glioma and verified the difference in results from the Sanger DNA sequencing results.	Paraffin	142-150	telomerase reverse transcriptase	Homo sapiens	83-87
34092577-5	2021	METHODS: The immunohistochemical staining technique was used to show the expression of FBP1 and LDHB in formalin-fixed, paraffin-embedded blocks of 32 fibroadenomas and 31 invasive breast cancer samples.	Paraffin	120-128	lactate dehydrogenase B	Homo sapiens	96-100
35586706-3	2022	Expression of a three-gene signature (IGFBP3, F3, VGLL3) was measured in formalin-fixed paraffin-embedded material from diagnostic core needle biopsies (CNB) of these patients.	Paraffin	88-96	insulin like growth factor binding protein 3	Homo sapiens	38-44
35088378-6	2022	METHODS: The probe and primer sets were designed according to the MethyLight method for quantitative assessment of the mSHOX2 in 214 formalin-fixed paraffin-embedded (FFPE) lung tissues and 57 plasma samples.	Paraffin	148-156	short stature homeobox 2	Mus musculus	119-125
35189545-4	2022	MATERIALS & METHODS: Patient-derived tissue samples from 35 paraffin-embedded tumors were used to assess beta-catenin immunoexpression.	Paraffin	60-68	catenin beta 1	Homo sapiens	105-117
35253509-0	2022	Vascular E-selectin Expression Detected in Formalin-fixed, Paraffin-embedded Sections With an E-selectin Monoclonal Antibody Correlates With Ulcerative Colitis Activity.	Paraffin	59-67	selectin E	Homo sapiens	9-19
35253509-2	2022	However, immunohistological analysis of E-selectin has been hampered by lack of E-selectin-specific monoclonal antibodies that can stain formalin-fixed, paraffin-embedded (FFPE) tissue sections.	Paraffin	153-161	selectin E	Homo sapiens	80-90
2483185-3	1989	Formalin-paraffin sections of both tumors were stained positively by PSA (prostatic specific antigen) and PAP (prostatic acid phosphatase) using B-SA (biotin-streptavidin) system technique and prostatic origin of the breast mass was confirmed.	Paraffin	9-17	acid phosphatase 3	Homo sapiens	106-109
2483185-3	1989	Formalin-paraffin sections of both tumors were stained positively by PSA (prostatic specific antigen) and PAP (prostatic acid phosphatase) using B-SA (biotin-streptavidin) system technique and prostatic origin of the breast mass was confirmed.	Paraffin	9-17	acid phosphatase 3	Homo sapiens	111-137
2572685-3	1989	Antibodies to the protein product, p185, have been used for immunostaining of paraffin-embedded material, and have demonstrated that high levels of c-erbB-2 protein expression correlate with gene amplification under certain conditions.	Paraffin	78-86	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	35-39
2466563-1	1989	An IgG1 murine monoclonal antibody (PN-15) to an epitope preserved in formalin-fixed, paraffin-embedded tissue sections of renal cell carcinomas was developed following immunization of mice with the microsomal fraction of human renal cortical tissue homogenates.	Paraffin	86-94	LOC105243590	Mus musculus	3-7
2785426-4	1989	Immunohistochemical studies were carried out on embedded paraffin sections with the monoclonal antibody 4KB5 (CD45R) and were assessable in 4 of the 5 patients considered in CR and in 3 of the 4 cases with no Ig gene rearrangement.	Paraffin	57-65	protein tyrosine phosphatase receptor type C	Homo sapiens	110-115
2760966-1	1989	Rabbit antiserum to Pre-S1 protein was used to establish peroxidase-antiperoxidase (PAP) and avidin-biotin-peroxidase complex (ABC) immunohistochemical techniques for detection of Pre-S1 protein in paraffin-embedded liver tissue.	Paraffin	198-206	large envelope protein;middle envelope protein;small envelope protein	Hepatitis B virus	20-26
2760966-1	1989	Rabbit antiserum to Pre-S1 protein was used to establish peroxidase-antiperoxidase (PAP) and avidin-biotin-peroxidase complex (ABC) immunohistochemical techniques for detection of Pre-S1 protein in paraffin-embedded liver tissue.	Paraffin	198-206	large envelope protein;middle envelope protein;small envelope protein	Hepatitis B virus	180-186
3263805-2	1988	Immunoreactivity for L26, a highly effective pan B cell marker that can be detected in paraffin sections, was evaluated in 72 cases of Hodgkin"s disease of various histologic types.	Paraffin	87-95	ribosomal protein L26	Homo sapiens	21-24
3403971-0	1988	The new monoclonal antibody (Mac 387) that reacts with macrophages on paraffin sections detects the well-known leukocyte L1 antigen.	Paraffin	70-78	S100 calcium binding protein A9	Homo sapiens	29-36
3054827-3	1988	We have studied ABO (H) BGA expression in paraffin sections of gastric specimens using immunofluorescence techniques with monoclonal antibodies.	Paraffin	42-50	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	16-19
3258730-2	1988	This report describes an improved technique for sensitive and specific localization of terminal deoxynucleotidyl transferase (TdT) in routinely processed paraffin-embedded, formalin-fixed tissue sections using DNAse pretreatment and the avidin-biotin complex (ABC) technique.	Paraffin	154-162	DNA nucleotidylexotransferase	Homo sapiens	87-124
3258730-2	1988	This report describes an improved technique for sensitive and specific localization of terminal deoxynucleotidyl transferase (TdT) in routinely processed paraffin-embedded, formalin-fixed tissue sections using DNAse pretreatment and the avidin-biotin complex (ABC) technique.	Paraffin	154-162	DNA nucleotidylexotransferase	Homo sapiens	126-129
3681029-1	1986	c-Ki-ras-2 sequences were visualized in paraffin-embedded sections from normal fetal and adult human pancreases, a chemically induced transplantable human pancreas carcinoma (PT-1) and three carcinomas of pancreas by in situ hybridization technique.	Paraffin	40-48	KRAS proto-oncogene, GTPase	Homo sapiens	0-8
3522808-2	1986	The presence of GFAP within radial glia was demonstrated in vibratome sections, in de-eponized 1 micron sections and in paraffin-embedded sections both at light and EM levels in suitably fixed human fetal cerebral tissue.	Paraffin	120-128	glial fibrillary acidic protein	Homo sapiens	16-20
3513600-3	1986	When alcohol-fixed paraffin-embedded material was used, neurofilament staining was weaker and the fixation procedure appeared to destroy the epitopes recognized by the NF-L antibodies preferentially.	Paraffin	19-27	neurofilament light chain	Homo sapiens	168-172
3882581-1	1985	A monoclonal antibody (MAb NKI/C-3) produced against a purified membrane preparation of human melanoma cells reacts preferentially with sections of formaldehyde-fixed and paraffin-embedded tissues of melanoma, nevocellular nevi, carcinoids and medullary carcinomas of the thyroid.	Paraffin	171-179	complement C3	Homo sapiens	31-34
2985184-2	1985	We also performed immunostaining for these 3 pro-opiomelanocortin (POMC) derived peptides on paraffin embedded serial sections of the hypothalamus.	Paraffin	93-101	proopiomelanocortin	Rattus norvegicus	67-71
6203932-2	1984	Immune staining for the myelin-associated glycoprotein (MAG) by the peroxidase-antiperoxidase technique in vibratome, paraffin and Epon sections of peripheral nerve resulted in a periaxonal ring of immune reaction product and an absence of staining over compact myelin.	Paraffin	118-126	myelin associated glycoprotein	Homo sapiens	24-54
6203932-2	1984	Immune staining for the myelin-associated glycoprotein (MAG) by the peroxidase-antiperoxidase technique in vibratome, paraffin and Epon sections of peripheral nerve resulted in a periaxonal ring of immune reaction product and an absence of staining over compact myelin.	Paraffin	118-126	myelin associated glycoprotein	Homo sapiens	56-59
6200494-8	1984	In paraffin sections of developing CNS, both monoclonal and polyclonal MAG antisera stained oligodendroglia and myelin.	Paraffin	3-11	myelin associated glycoprotein	Homo sapiens	71-74
6368594-1	1984	An evaluation of Ca 1 antibody staining was performed on paraffin sections from 136 breast lesions (64 benign and 72 malignant).	Paraffin	57-65	carbonic anhydrase 1	Homo sapiens	17-21
6336978-5	1983	By employing an immunoperoxidase technique using prostatic acid phosphatase as the marker for the prostatic cells, we demonstrated the presence of the prostatic enzyme antigen in the paraffin embedded tissues from the metastatic tumor.	Paraffin	183-191	acid phosphatase 3	Homo sapiens	49-75
6174565-0	1982	Processing techniques for the demonstration of myelin basic protein in paraffin-embedded optic nerve: an immunoperoxidase study of the developing albino rat.	Paraffin	71-79	myelin basic protein	Rattus norvegicus	47-67
6174565-1	1982	A comparison was made of the effects of various fixation and processing conditions upon the antigenicity of myelin basic protein (MBP) in sections of paraffin-embedded optic nerve from the developing albino rat as judged by the unlabeled peroxidase-antiperoxidase technique.	Paraffin	150-158	myelin basic protein	Rattus norvegicus	108-128
7037942-7	1982	It was found that some, but not all, monoclonal antibodies can be used for the detection of prostatic acid phosphatase in paraffin sections.	Paraffin	122-130	acid phosphatase 3	Homo sapiens	92-118
6820938-3	1982	Rather than the less specific phosphotungstic acid hematoxylin (PTAH) or Holzer"s stain, antibody to GFAP protein is a relatively rapid, simple, and reliable immunohistochemical technique for formalin-fixed and paraffin-embedded tissue.	Paraffin	211-219	glial fibrillary acidic protein	Homo sapiens	101-105
7032307-2	1981	We have demonstrated TdT in the nuclei of cortical thymocytes in paraffin-embedded sections of calf, rat, and human thymus by indirect immunoperoxidase techniques.	Paraffin	65-73	DNA nucleotidylexotransferase	Bos taurus	21-24
15394-1	1977	Kallikrein was isolated from paraffin stimulated saliva by use of two steps affinity chromatography.	Paraffin	29-37	kallikrein related peptidase 4	Homo sapiens	0-10
33675098-3	2021	Here, we performed mutation-specific RNA in situ hybridization to evaluate mutant allele expression of KRAS p.G12V, the most frequently detected mutation in ovarian endometriosis in our previous study, in formalin-fixed paraffin-embedded tissue (FFPE) samples of ovarian endometriosis, cancer cell lines, and ovarian cancers.	Paraffin	220-228	KRAS proto-oncogene, GTPase	Homo sapiens	103-107
33734108-3	2021	In this study, formalin fixed paraffin embedded clinical specimens (16 liposarcomas and 19 benign lipomatous tumors) were used to detect MDM2 amplification and other chromosomal alterations in WDLS/ALT and DDLS by single nucleotide polymorphism-based chromosome microarray (CMA).	Paraffin	30-38	MDM2 proto-oncogene	Homo sapiens	137-141
33734108-12	2021	In conclusion, this study demonstrated that CMA on routine formalin fixed paraffin embedded tissue is a sensitive and specific clinical test for detection of MDM2 gene amplification.	Paraffin	74-82	MDM2 proto-oncogene	Homo sapiens	158-162
33677883-3	2021	The protein expression of LEF1 and TdT was detected by immunohistochemistry in 53 paraffin-embedded tissue samples of LBL/ALL.	Paraffin	82-90	DNA nucleotidylexotransferase	Homo sapiens	35-38
32590454-0	2021	Aberrant Cytoplasmic Terminal Deoxynucleotidyl Transferase (TdT) Immunostaining on Previously Frozen, Formalin-fixed Paraffin-embedded Tissue: Cryotomy-induced Antigen Diffusion (CIAD).	Paraffin	117-125	DNA nucleotidylexotransferase	Homo sapiens	21-58
32590454-0	2021	Aberrant Cytoplasmic Terminal Deoxynucleotidyl Transferase (TdT) Immunostaining on Previously Frozen, Formalin-fixed Paraffin-embedded Tissue: Cryotomy-induced Antigen Diffusion (CIAD).	Paraffin	117-125	DNA nucleotidylexotransferase	Homo sapiens	60-63
32590454-1	2021	Terminal deoxynucleotidyl transferase (TdT) has been localized in both the nuclear and cytoplasmic compartments of lymphoblastic lymphomas when such tumors have been frozen for cryotomy and subsequently, formalin fixed and processed to paraffin.	Paraffin	236-244	DNA nucleotidylexotransferase	Homo sapiens	0-37
32590454-1	2021	Terminal deoxynucleotidyl transferase (TdT) has been localized in both the nuclear and cytoplasmic compartments of lymphoblastic lymphomas when such tumors have been frozen for cryotomy and subsequently, formalin fixed and processed to paraffin.	Paraffin	236-244	DNA nucleotidylexotransferase	Homo sapiens	39-42
33341450-3	2021	PATIENT AND METHODS: CDX2 protein expression was evaluated in 386 stage II and III primary colon cancers by immunohistochemical staining of tissue microarrays and by liquid chromatography with tandem mass spectrometry (LC-MS/MS) analysis using formalin-fixed paraffin-embedded tissue sections of a matched subset of 23 recurrent and 23 non-recurrent colon cancers.	Paraffin	259-267	caudal type homeobox 2	Homo sapiens	21-25
33430620-6	2021	This procedure was applied to paraffin sections of CNS tissue from CISD2 deficient and littermate control mice.	Paraffin	30-38	CDGSH iron sulfur domain 2	Mus musculus	67-72
33308125-5	2021	Mice in group 1 were treated with vehicle control alone, while mice in Group 2 received a single intraperitoneal injection of 1 ml/kg CCl4 in liquid paraffin (1:1 v/v).	Paraffin	149-157	chemokine (C-C motif) ligand 4	Mus musculus	134-138
33170154-3	2020	METHODS: Immunohistochemical (IHC) and CD34-periodic acid-Schiff (PAS) double staining were used to investigate Glioma-associated oncogene-1(GLI1) expression and VM in paraffin-embedded sections from 127 patients with GC of all tumor stages.	Paraffin	168-176	GLI family zinc finger 1	Homo sapiens	112-140
32573984-1	2020	BACKGROUND: Insulinoma-associated protein 1 (INSM1) has recently emerged as a reliable nuclear immunostaining marker for detecting neuroendocrine tumors (NETs) in paraffin-embedded surgical samples and cytologic cell blocks, but the reliability of INSM1 staining on cytologic smears is understudied.	Paraffin	163-171	INSM transcriptional repressor 1	Homo sapiens	12-43
32573984-1	2020	BACKGROUND: Insulinoma-associated protein 1 (INSM1) has recently emerged as a reliable nuclear immunostaining marker for detecting neuroendocrine tumors (NETs) in paraffin-embedded surgical samples and cytologic cell blocks, but the reliability of INSM1 staining on cytologic smears is understudied.	Paraffin	163-171	INSM transcriptional repressor 1	Homo sapiens	45-50
32733643-5	2020	Marker potential of S100A8 and S100A9 was confirmed by immunohistochemistry of paraffin-embedded pathological samples.	Paraffin	79-87	S100 calcium binding protein A9	Homo sapiens	31-37
32733643-9	2020	Furthermore, marker potential of lysophospholipids was supported by elevated expression levels of the lysophospholipid degrading enzyme lysophospholipase A1 (LYPLA1) in the tumor regions of paraffin-embedded HNSCC samples.	Paraffin	190-198	lysophospholipase 1	Homo sapiens	136-156
32733643-9	2020	Furthermore, marker potential of lysophospholipids was supported by elevated expression levels of the lysophospholipid degrading enzyme lysophospholipase A1 (LYPLA1) in the tumor regions of paraffin-embedded HNSCC samples.	Paraffin	190-198	lysophospholipase 1	Homo sapiens	158-164
32753895-3	2020	The expression of ZNF711 was detected by immunohistochemistry in paraffin blocks of BCa.	Paraffin	65-73	zinc finger protein 711	Homo sapiens	18-24
32011345-3	2020	BCOR immunohistochemistry was performed on archival formalin-fixed paraffin-embedded tumor tissue in 13 of 14 adenosarcomas with and without stromal overgrowth arising in the uterus or ovary.	Paraffin	67-75	BCL6 corepressor	Homo sapiens	0-4
32124385-6	2020	METHODS: Five BRCA1 variants affecting splicing were characterized from formalin-fixed, paraffin-embedded (FFPE) ovarian carcinoma tissues by next-generation sequencing (NGS).	Paraffin	88-96	BRCA1 DNA repair associated	Homo sapiens	14-19
32190664-3	2020	We observed and quantified the expression of Snail, galectin-3, and IGF1R in paraffin-embedded samples by immunohistochemical staining.	Paraffin	77-85	insulin like growth factor 1 receptor	Homo sapiens	68-73
31856055-5	2019	The experiment was to detect MYH7 gene status in formalin-fixed paraffin-embedded tissues from 18 independent autopsy cases who suffered HCM related sudden death (fatal HCM) and 20 cases without cardiomyopathy.	Paraffin	64-72	myosin heavy chain 7	Homo sapiens	29-33
31651105-8	2019	CONCLUSION: Our findings assessed the implementation of RNA-sequencing approaches to explore ALK and ROS1 rearrangements from formalin-fixed paraffin-embedded samples.	Paraffin	141-149	ALK receptor tyrosine kinase	Homo sapiens	93-96
31570282-0	2019	BRCA1/2 somatic mutation detection in formalin-fixed paraffin embedded tissue by next-generation sequencing in Korean ovarian cancer patients.	Paraffin	53-61	BRCA1 DNA repair associated	Homo sapiens	0-7
31570282-3	2019	The purpose of this study was to consider several conditions of NGS BRCA1/2 assay applicable to clinical laboratory tests, in particular for using formalin fixed paraffin embedded (FFPE) ovarian tissues.	Paraffin	162-170	BRCA1 DNA repair associated	Homo sapiens	68-73
31305441-5	2019	The protein expression of PYCR1 was evaluated by immunostaining formalin-fixed, paraffin-embedded sections of RCC samples from 96 patients who underwent radical nephrectomy, and its relationship with clinical features were analyzed.	Paraffin	80-88	pyrroline-5-carboxylate reductase 1	Homo sapiens	26-31
31208108-5	2019	Materials and Method: We performed a literature search for miR expression in EC using MEDLINE, PubMed (the Internet portal of the National Library of Medicine) and The Cochrane Library, Cochrane databases "Cochrane Reviews" and "Clinical Trials" using the following keywords: microRNA, endometrial cancer, prognosis, diagnosis, lymph node, survival, plasma, FFPE (formalin-fixed, paraffin-embedded).	Paraffin	380-388	membrane associated ring-CH-type finger 8	Homo sapiens	59-62
31196136-3	2019	METHODS: Expression of SIRT7 in 17 paired paraffin-embedded HCC tissues and adjacent nontumoral liver tissues was examined by immunohistochemistry and Western blot.	Paraffin	42-50	sirtuin 7	Homo sapiens	23-28
31231230-6	2019	Immunohistochemistry was performed on paraffin-embedded brain tissue blocks from this case with ACTG1 variant and an age-matched control.	Paraffin	38-46	actin gamma 1	Homo sapiens	96-101
30537291-4	2019	METHODS: FAK and cortactin expression was analyzed by immunohistochemistry on paraffin-embedded tissue samples from 100 patients with cSCC, and correlated with the clinical data.	Paraffin	78-86	cortactin	Homo sapiens	17-26
31205531-4	2019	Methods: The expression profile of DACT-2 of was detected by qRT-PCR, Western blotting, and immunohistochemistry in four prostate cell lines (RWPE-1, LNCaP, PC-3 and DU145), 56 cases of frozen prostate tissues (forty-seven primary prostate carcinomas, nine paired noncancerous and cancerous prostate tissues) and a tissue microarray sets including 100 paraffin-embedded prostate samples (3 normal tissues, 2 cases of adjacent tissues and 95 cases of cancer).	Paraffin	352-360	dishevelled binding antagonist of beta catenin 2	Homo sapiens	35-41
30710424-4	2019	It was found that SIRT1 was overexpressed in 300 (62%) of 485 formalin-fixed paraffin-embedded NSCLC tissues.	Paraffin	77-85	sirtuin 1	Homo sapiens	18-23
30915272-5	2019	Methods: Co-expression of CK8 and Vim was evaluated by immunofluorescence (IF) on paraffin-embedded tissue sections of 122 patients with PCa who underwent radical prostatectomies between 1998 and 2016 at the American University of Beirut Medical Center (AUBMC).	Paraffin	82-90	keratin 8	Homo sapiens	26-29
30816829-0	2019	Validation of CD137 Immunohistochemical Stain on Paraffin-Embedded Tissue as a Marker to Facilitate Distinction Between Classic Hodgkin Lymphoma, Nodular Lymphocyte-Predominant Hodgkin Lymphoma, T-Cell/Histiocyte-Rich Large B-Cell Lymphoma, and Anaplastic Large Cell Lymphoma.	Paraffin	49-57	TNF receptor superfamily member 9	Homo sapiens	14-19
30797498-4	2019	Standard immunohistochemistry was performed on formalin-fixed paraffin-embedded tissue sections using antibody against LC3A autophagic potein.	Paraffin	62-70	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	119-123
30811471-0	2019	Integrated routine workflow using next-generation sequencing and a fully-automated platform for the detection of KRAS, NRAS and BRAF mutations in formalin-fixed paraffin embedded samples with poor DNA quality in patients with colorectal carcinoma.	Paraffin	161-169	KRAS proto-oncogene, GTPase	Homo sapiens	113-117
30439350-6	2019	Here, using antibodies against TKS5 and Cortactin, we describe for the first time structures strongly resembling invadopodia in various paraffin-embedded human tumor surgical specimens from pancreas and other organs.	Paraffin	136-144	cortactin	Homo sapiens	40-49
30666091-8	2019	Next-generation sequencing of formalin-fixed paraffin-embedded RC tissues showed MDM2 amplification without MDM4 amplification, EGFR aberrations, or DNMT3A alterations.	Paraffin	45-53	MDM2 proto-oncogene	Homo sapiens	81-85
30321514-3	2018	We assessed the expression of GLI1 and its relationship with other cancer stemness genes, cell cycle markers, epithelial-mesenchymal transition (EMT), PI3K/Akt/NFkappaB signaling pathway genes, and HIF1alpha in 100 paraffin-embedded colorectal adenocarcinoma tissue samples using immunohistochemistry.	Paraffin	215-223	GLI family zinc finger 1	Homo sapiens	30-34
30075150-4	2018	Specifically, preliminary results in paraffin-embedded myometrial tissues have shown increased STRO-1+/CD44+ MyoSCs in African American versus Caucasian women.	Paraffin	37-45	CD44 molecule (Indian blood group)	Homo sapiens	103-107
30121842-4	2018	METHODS: Immunohistochemistry was performed to measure the expression of NUAK1 in paraffin-embedded NPC samples.	Paraffin	82-90	NUAK family kinase 1	Homo sapiens	73-78
29514107-4	2018	The novel ALK fusion was identified by a 5"-rapid amplification of cDNA ends-based system optimized for formalin-fixed, paraffin-embedded tissue.	Paraffin	120-128	ALK receptor tyrosine kinase	Homo sapiens	10-13
30189360-3	2018	We showed that FOXF1 was up-regulated in 93 paraffin-embedded archived human CRC tissue, and both high expression and nuclear location of FOXF1 were significantly associated with the aggressive characteristics and poorer survival of CRC patients.	Paraffin	44-52	forkhead box F1	Homo sapiens	15-20
30241382-4	2018	Here, we evaluated ZKSCAN3 expression in uterine cervical cancers (CC) by immunohistochemistry using formalin-fixed, paraffin-embedded tissues from 126 biopsy samples from 126 patients.	Paraffin	117-125	zinc finger with KRAB and SCAN domains 3	Homo sapiens	19-26
29744991-6	2018	The method is applied in the 45-min analysis of specific methylation in the MGMT promoter region directly in raw spiked human serum samples and in genomic DNA extracted from U-87 glioblastoma cells and paraffin-embedded brain tumor tissues without any amplification and pretreatment step.	Paraffin	202-210	O-6-methylguanine-DNA methyltransferase	Homo sapiens	76-80
29979177-7	2018	This work has demonstrated that the improvement in contrast-to-noise ratio by PBI enabled label-free virtual histology of soft-tissue specimens embedded in paraffin to a level of detail that exceeds that achieved with staining protocols.	Paraffin	156-164	submaxillary gland androgen regulated protein 3A	Homo sapiens	78-81
29875690-4	2018	In our study, we detected the expression of beta3GnT8, CD147, MMP2, and galectin3 by immunohistochemistry on 90 paraffin-embedded slices.	Paraffin	112-120	UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 8	Homo sapiens	44-53
29783799-11	2018	The paraffin-embedded tissues of all cases showed immunoreactivity for NSE and Syn, and the positive propotion of CgA was 10/17.	Paraffin	4-12	synemin	Homo sapiens	79-82
29725449-5	2018	Immunohistochemical analysis revealed that UBE2A protein was more strongly stained in the 276 paraffin-embedded HCC tissues as compared with the 63 adjacent normal tissue.	Paraffin	94-102	ubiquitin conjugating enzyme E2 A	Homo sapiens	43-48
29970727-0	2018	Correlation and discrepancy of phospholipase A2 receptor staining in membranous nephropathy in paraffin-embedded kidney biopsies.	Paraffin	95-103	phospholipase A2 receptor 1	Homo sapiens	31-56
29970727-4	2018	Here, we measure the correlation and discrepancy of PLA2R on MN in paraffin-embedded kidney biopsies by correlating PLA2R findings with immunofluorescence (IF), light microscopy (LM), and electron microscopy (EM) results.	Paraffin	67-75	phospholipase A2 receptor 1	Homo sapiens	52-57
29719408-4	2018	Methods: The expression levels of DGCR9 in each patient between formalin-fixed, paraffin-embedded (FFPE) gastric cancer tissues and adjacent noncancer tissues (NAT) (n=102) were measured by quantitative reverse-transcription polymerase chain reaction (qRT-PCR).	Paraffin	80-88	DiGeorge syndrome critical region gene 9	Homo sapiens	34-39
29900041-3	2018	In this study, positive correlations between NTS and interleukin (IL)-8 were identified at both the mRNA and protein levels in 71 fresh HCC tissues and 100 paraffin-embedded HCC tissues.	Paraffin	156-164	neurotensin	Mus musculus	45-48
29534467-0	2018	Expanding the Utilization of Formalin-Fixed, Paraffin-Embedded Archives: Feasibility of miR-Seq for Disease Exploration and Biomarker Development from Biopsies with Clear Cell Renal Cell Carcinoma.	Paraffin	45-53	membrane associated ring-CH-type finger 8	Homo sapiens	88-91
29378601-5	2018	The aim of this study was to evaluate the immunohistochemical expression of retinoic acid receptor alpha (RARA) and CRABP2 in paraffin-embedded samples of nephroblastomas via semiquantitative and quantitative analyses and to correlate this expression with prognostic factors.	Paraffin	126-134	cellular retinoic acid binding protein 2	Homo sapiens	116-122
30196292-4	2018	Immunohistochemistry was performed to detect ZAP expression in 147 paraffin-embedded HCC tissues and adjacent normal tissues.	Paraffin	67-75	zinc finger CCCH-type containing, antiviral 1	Homo sapiens	45-48
29069647-8	2018	We detected less Ki67 and proliferation cell nuclear antigen in paraffin sections from xenograft tumor specimens taken from alpha-pinene-treated mice than in those from the control group.	Paraffin	64-72	antigen identified by monoclonal antibody Ki 67	Mus musculus	17-21
29578163-6	2018	Materials and Methods: The expression level of miR-371-373 cluster was analyzed in paraffin-embedded tissues of tumor and tumor margin in 36 patients with ESCC.	Paraffin	83-91	microRNA 371a	Homo sapiens	47-54
28631286-4	2017	Immunohistochemical staining of 167 paraffin-embedded BCa tissues was performed, and the results showed that high Med19 protein level was positively correlated with clinical stages and histopathological grade.	Paraffin	36-44	mediator complex subunit 19	Homo sapiens	114-119
29279584-9	2017	The expression of NANOG in 100 formalin-fixed paraffin-embedded urothelial carcinoma tissues was determined by immunohistochemistry.	Paraffin	46-54	Nanog homeobox	Homo sapiens	18-23
28059652-3	2017	METHODS The authors performed immunohistochemical analysis to detect both the PRR and isocitrate dehydrogenase 1 with mutations involving arginine 132 ( IDH1R132H) in paraffin sections of 31 gliomas.	Paraffin	167-175	ATPase H+ transporting accessory protein 2	Homo sapiens	78-81
28855989-3	2017	Tim-3 protein expression was measured in 150 paraffin-embedded IDC specimens and 100 paired normal breast tissue specimens by immunohistochemistry.	Paraffin	45-53	hepatitis A virus cellular receptor 2	Homo sapiens	0-5
29100430-7	2017	Here we identify and validate a novel highly NAPRT-specific monoclonal antibody (3C6D2) that detects functional NAPRT in paraffin embedded tissue sections by immunohistochemistry (IHC).	Paraffin	121-129	nicotinate phosphoribosyltransferase	Homo sapiens	45-50
29100430-7	2017	Here we identify and validate a novel highly NAPRT-specific monoclonal antibody (3C6D2) that detects functional NAPRT in paraffin embedded tissue sections by immunohistochemistry (IHC).	Paraffin	121-129	nicotinate phosphoribosyltransferase	Homo sapiens	112-117
28409272-6	2017	METHODS: Immunohistochemical analyses were carried out to detect TAAR1 expression in formalin fixed paraffin embedded breast cancer samples.	Paraffin	100-108	trace amine associated receptor 1	Homo sapiens	65-70
28376189-4	2017	BRCA1/2 testing of most prevalent mutations was mainly done using DNA isolate from formalin-fixed paraffin-embedded nontumor tissue.	Paraffin	98-106	BRCA1 DNA repair associated	Homo sapiens	0-5
28188754-7	2017	High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded clinical sample unveiled a novel NUTM2A-CIC fusion between NUTM2A exon 7 and CIC exon 12, and fluorescence in situ hybridization identified CIC and NUTM2A split signals.	Paraffin	52-60	NUT family member 2A	Homo sapiens	103-109
28188754-7	2017	High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded clinical sample unveiled a novel NUTM2A-CIC fusion between NUTM2A exon 7 and CIC exon 12, and fluorescence in situ hybridization identified CIC and NUTM2A split signals.	Paraffin	52-60	NUT family member 2A	Homo sapiens	129-135
28188754-7	2017	High-throughput RNA sequencing of a formalin-fixed, paraffin-embedded clinical sample unveiled a novel NUTM2A-CIC fusion between NUTM2A exon 7 and CIC exon 12, and fluorescence in situ hybridization identified CIC and NUTM2A split signals.	Paraffin	52-60	NUT family member 2A	Homo sapiens	129-135
28675018-5	2017	Double immunohistochemical analysis was applied to investigate the expression of CD44 and CD133 in paraffin sections of normal oral mucosa, OPMD, and OSCC tissues.	Paraffin	99-107	CD44 molecule (Indian blood group)	Homo sapiens	81-85
28425229-2	2017	MATERIALS AND METHODS: In this study B7-H4 gene rs10754339, rs10801935, and rs3738414 SNPs were studied by PCR-RFLP method in paraffin-embedded tumor specimens from 62 urothelial carcinoma patients and in a control group including 30 patients without bladder cancer.	Paraffin	126-134	V-set domain containing T cell activation inhibitor 1	Homo sapiens	37-42
28251919-9	2017	Expression of DCC, UNC5A, and Caspr2 proteins was demonstrated in paraffin-embedded thymoma samples (3) and normal thymus.	Paraffin	66-74	DCC netrin 1 receptor	Homo sapiens	14-17
28251919-9	2017	Expression of DCC, UNC5A, and Caspr2 proteins was demonstrated in paraffin-embedded thymoma samples (3) and normal thymus.	Paraffin	66-74	unc-5 netrin receptor A	Homo sapiens	19-24
27761802-3	2017	Promoter methylation status of LATS1/2 genes was evaluated in 70 OSCC paraffin-embedded tissues and 70 normal oral samples, using Methylation Specific PCR (MSP).	Paraffin	70-78	large tumor suppressor kinase 2	Homo sapiens	31-38
28255115-3	2017	The protein expressions of CXCL12, CXCR4 and CXCR7 in paraffin-embedded samples from 160 patients with different molecular subtypes were detected by immunohistochemical staining.	Paraffin	54-62	atypical chemokine receptor 3	Homo sapiens	45-50
27930669-3	2016	In this study, we developed a novel RNA-FISH assay using branched DNA probe to detect FGFR3-TACC3 fusions in formaldehyde-fixed paraffin-embedded (FFPE) human BC samples.	Paraffin	128-136	fibroblast growth factor receptor 3	Homo sapiens	86-91
27060609-3	2016	EML4-ALK was identified using paraffin-embedded tumour cells in MPE samples by immunohistochemistry (IHC, Ventana) and confirmed by fluorescence using in situ hybridisation (FISH) and qRT-PCR.	Paraffin	30-38	EMAP like 4	Homo sapiens	0-4
27060609-3	2016	EML4-ALK was identified using paraffin-embedded tumour cells in MPE samples by immunohistochemistry (IHC, Ventana) and confirmed by fluorescence using in situ hybridisation (FISH) and qRT-PCR.	Paraffin	30-38	ALK receptor tyrosine kinase	Homo sapiens	5-8
27933184-4	2016	DESIGN: Immunohistochemistry for CAR was performed on paraffin-embedded pancreatic tissue from patients with T1D (n=9 recent onset T1D, n=4 long-standing T1D), islet autoantibody-positive individuals (n=14) and non-diabetic controls (n=24) individuals.	Paraffin	54-62	CXADR Ig-like cell adhesion molecule	Homo sapiens	33-36
27573674-6	2016	CAP2 protein expression was analyzed in paraffin-embedded breast cancer samples, paired adjacent non-tumor and normal breast tissues by immunohistochemical analysis.	Paraffin	40-48	cyclase associated actin cytoskeleton regulatory protein 2	Homo sapiens	0-4
27573674-10	2016	In paraffin-embedded tissue samples, the expression of CAP2 was higher in breast cancer than that found in the adjacent non-cancerous tissues and normal breast tissues.	Paraffin	3-11	cyclase associated actin cytoskeleton regulatory protein 2	Homo sapiens	55-59
27599983-6	2016	The expressions of HSP90B1 and DDIT3 proteins were detected in all paraffin-embedded biopsy samples by immunochemistry.	Paraffin	67-75	heat shock protein 90 beta family member 1	Homo sapiens	19-26
27533253-2	2016	This raises the need for new diagnostic methods that are capable of performing an integrative mutation analysis of the BRCA genes not only from germline DNA but also from formalin-fixed and paraffin-embedded (FFPE) tumor samples.	Paraffin	190-198	BRCA1 DNA repair associated	Homo sapiens	119-123
27542245-2	2016	METHODS: The MGMT status of 139 glioblastoma patients, whom had received standard first line treatment, was determined using pyrosequencing (PSQ) and a semi-quantitative Methylation-specific PCR (sqMS-PCR) method, using both frozen and formalin-fixed paraffin-embedded FFPE samples.	Paraffin	251-259	O-6-methylguanine-DNA methyltransferase	Homo sapiens	13-17
27648355-5	2016	Immunohistochemistry (IHC) was conducted to characterize the expression pattern of SERPINA4 by using a tissue microarray (TMA) containing 327 archived paraffin-embedded CRC specimens.	Paraffin	151-159	serpin family A member 4	Homo sapiens	83-91
27418340-7	2016	By immunohistochemistry, IGF1R expression levels were determined in tissue microarrays of 187 cartilage tumours and ten paraffin embedded cell lines.	Paraffin	120-128	insulin like growth factor 1 receptor	Homo sapiens	25-30
27256048-2	2016	METHODS: Polymerase chain reaction and DNA sequencing were used to detect mutations of BRCA1 (exons 2, 11 and 20) and BRCA2 (exon 11) genes using paraffin-embedded tissue samples of 33 TNBC patients (21 Uyghur patients and 12 Han patients ) in Xinjiang Uygur Autonomous Region.	Paraffin	146-154	BRCA1 DNA repair associated	Homo sapiens	87-92
27003155-4	2016	Next-generation sequencing (NGS) approaches employing targeted panels for BRCA1/2 to interrogate formalin-fixed and paraffin-embedded tumor samples from either surgical resection or biopsy specimens can overcome these limitations.	Paraffin	116-124	BRCA1 DNA repair associated	Homo sapiens	74-81
26898937-5	2016	Among them four novel fusion genes SEPT9/CYHR, IGF1R/TTC23, SYT8/TNNI2 and CASZ1/DFFA were validated and characterized in 48 formalin-fixed paraffin-embedded (FFPE) specimens of bladder cancer.	Paraffin	140-148	insulin like growth factor 1 receptor	Homo sapiens	47-52
26662803-0	2016	Aberrant expression of Notch1, HES1, and DTX1 genes in glioblastoma formalin-fixed paraffin-embedded tissues.	Paraffin	83-91	deltex E3 ubiquitin ligase 1	Homo sapiens	41-45
26925122-3	2016	MATERIAL AND METHODS: The immunohistochemical method was used to examine the immunoexpression of ADAM33 in 39 formalin-fixed, paraffin-embedded tissue specimens of sinonasal inverted papillomas (IP), 44 laryngeal squamous cell carcinomas (GI grade = 11, GII grade = 33) and 14 disease-free tissue specimens as a control.	Paraffin	126-134	ADAM metallopeptidase domain 33	Homo sapiens	97-103
26893713-3	2016	The expression of Sirt1 was detected by the immunohistochemical streptavidin peroxidase detection method in paraffin-embedded sections, whilst Sirt1 protein expression was examined by western blot analysis in the fresh tissues.	Paraffin	108-116	sirtuin 1	Homo sapiens	18-23
26812617-0	2016	Validation of a Multiplex Allele-Specific Polymerase Chain Reaction Assay for Detection of KRAS Gene Mutations in Formalin-Fixed, Paraffin-Embedded Tissues from Colorectal Cancer Patients.	Paraffin	130-138	KRAS proto-oncogene, GTPase	Homo sapiens	91-95
26745875-0	2016	BRCA somatic and germline mutation detection in paraffin embedded ovarian cancers by next-generation sequencing.	Paraffin	48-56	BRCA1 DNA repair associated	Homo sapiens	0-4
27034530-3	2016	Fourteen TIO cases were retrieved and FGF23 expression was measured by quantitative ELISA-like immunohistochemistry using formalin-fixed and paraffin-embedded tissues.	Paraffin	141-149	fibroblast growth factor 23	Homo sapiens	38-43
27034530-7	2016	The quantitative ELISA-like immunohistochemistry was a feasible and reproducible procedure to detect the high FGF23 expression in formalin-fixed and paraffin-embedded biopsies or specimens.	Paraffin	149-157	fibroblast growth factor 23	Homo sapiens	110-115
26870280-6	2016	In addition, immunohistochemistry (IHC) was performed to identify the location and expression of ATF2 and p-ATF2 (threonine 71) in paraffin-embedded sections of NSCLC and adjacent normal tissue.	Paraffin	131-139	activating transcription factor 2	Homo sapiens	97-101
26870280-6	2016	In addition, immunohistochemistry (IHC) was performed to identify the location and expression of ATF2 and p-ATF2 (threonine 71) in paraffin-embedded sections of NSCLC and adjacent normal tissue.	Paraffin	131-139	activating transcription factor 2	Homo sapiens	108-112
26870280-7	2016	The results demonstrated that ATF2 was markedly overexpressed in the NSCLC cells and significantly overexpressed in the fresh NSCLC tissues compared with the control cells and samples (86 paraffin-embedded tissue sections), respectively (P&lt;0.01).	Paraffin	188-196	activating transcription factor 2	Homo sapiens	30-34
26374556-5	2015	Paraffin sections were used for immunohistochemical staining of CD2, CD3, CD8alpha, CD68, and CD163 antigens.	Paraffin	0-8	Cd2 molecule	Rattus norvegicus	64-67
26755907-5	2015	The expression of CXCR4 and CXCL12 was assessed by immunohistochemistry on the paraffin blocks and compared to the expression of angiogenesis marker (CD34) and proliferation indicators (Ki-67, AgNORs).	Paraffin	79-87	C-X-C motif chemokine receptor 4	Homo sapiens	18-23
26423151-4	2015	IL-25 expression was examined in paraffin-embedded tissue sections of liver from patients or in the livers from mice.	Paraffin	33-41	interleukin 25	Homo sapiens	0-5
26566974-4	2015	Immunofluorescence analysis of paraffin-embedded brain sections revealed that UbcM2 is ubiquitously expressed throughout the brain, is enriched in hindbrain and cortex, and is robustly expressed in neurons.	Paraffin	31-39	ubiquitin-conjugating enzyme E2E 1	Mus musculus	78-83
26507719-8	2015	Immunofluorescence double staining confirmed the co-localization of CD147 and MMP-11 in paraffin-embedded tissues of CRC patients.	Paraffin	88-96	matrix metallopeptidase 11	Homo sapiens	78-84
26265374-5	2015	METHODS: Tim-3 protein expressions were detected in paraffin embedded sections from 100 patients with BUC by immunohistochemistry.	Paraffin	52-60	hepatitis A virus cellular receptor 2	Homo sapiens	9-14
26081767-1	2015	BACKGROUND: The purpose of this study was to develop a cost-effective approach for the determination of EGFR and KRAS mutations in formalin-fixed paraffin-embedded (FFPE) non-small cell lung cancer (NSCLC) and colorectal cancer (CRC) samples from Chinese patients based on a sensitive pyrosequencing (PS) technique.	Paraffin	146-154	KRAS proto-oncogene, GTPase	Homo sapiens	113-117
26587331-3	2015	In this study, we have immunostained for CD137 on paraffin-embedded lymphoid tissues including tonsils, lymph nodes, ectopic tertiary lymphoid tissue in Hashimoto thyroiditis and cancer.	Paraffin	50-58	TNF receptor superfamily member 9	Homo sapiens	41-46
26191202-6	2015	Immunohistochemistry were performed to test the location and expression of Orai1 in paraffin sections.	Paraffin	84-92	ORAI calcium release-activated calcium modulator 1	Homo sapiens	75-80
26150151-8	2015	Immunohistochemical identification of CART cells was performed on paraffin for the UBs of all the study animals.	Paraffin	66-74	CART prepropeptide	Rattus norvegicus	38-42
25848214-4	2015	Paraffin blocks from 48 HCC patients were used to detect ADAMTS5 and vascular endothelial growth factor (VEGF) expression and microvessel density (MVD).	Paraffin	0-8	ADAM metallopeptidase with thrombospondin type 1 motif 5	Homo sapiens	57-64
25676400-2	2015	METHODS: EML4-ALK gene fusion in 85 cases of paraffin embedded tumor tissue and adjacent lung tissue was detected with the application of immunohistochemistry (IHC), Scorpions amplification refractory mutation system (Scorpions ARMS) fluorescence quantitative PCR and fluorescence in situ hybridization (FISH) technology, and EGFR gene in 18, 19, 20 and 21 exon mutation status was detected with the application of ARMS method.	Paraffin	45-53	EMAP like 4	Homo sapiens	9-13
25676400-2	2015	METHODS: EML4-ALK gene fusion in 85 cases of paraffin embedded tumor tissue and adjacent lung tissue was detected with the application of immunohistochemistry (IHC), Scorpions amplification refractory mutation system (Scorpions ARMS) fluorescence quantitative PCR and fluorescence in situ hybridization (FISH) technology, and EGFR gene in 18, 19, 20 and 21 exon mutation status was detected with the application of ARMS method.	Paraffin	45-53	ALK receptor tyrosine kinase	Homo sapiens	14-17
25561901-3	2015	FOXM1 expression was analyzed in 78 frozen lung adenocarcinoma tissue samples using an Affymetrix microarray and a 155-paraffin-embedded lung adenocarcinoma tissue microarray with immunohistochemical detection.	Paraffin	119-127	forkhead box M1	Homo sapiens	0-5
25498217-9	2014	Testis derived transcript (TES) protein expression was analyzed by immunohistochemistry in paraffin-embedded patient tissues.	Paraffin	91-99	testin LIM domain protein	Homo sapiens	27-30
24945428-0	2014	Results of first proficiency test for KRAS testing with formalin-fixed, paraffin-embedded cell lines in China.	Paraffin	72-80	KRAS proto-oncogene, GTPase	Rattus norvegicus	38-42
25038272-3	2014	In this study we investigated Bcl-6 translocation and its transcriptional and translational levels in formalin-fixed, paraffin-embedded cerebral tissue sections from glioblastoma (GBM), low-grade glioma (Astrocytoma grade II and III), and meningioma patients, and correlated them with apoptotic processes and p53 and caspase-3 expression.	Paraffin	118-126	BCL6 transcription repressor	Homo sapiens	30-35
25053596-5	2014	FLOT2 protein expression was also analyzed in archived paraffin-embedded RCC tissues using immunohistochemistry (IHC), and its association with overall survival of patients was analyzed by statistical analysis.	Paraffin	55-63	flotillin 2	Homo sapiens	0-5
24891594-5	2014	Histolocalization of HA in formalin-fixed, paraffin-embedded tissue sections using biotin-TSG-6-DeltaHep-Fc resulted in hyaluronidase-sensitive staining patterns similar to those obtained with biotin-HABP, but with improved sensitivity.	Paraffin	43-51	TNF alpha induced protein 6	Homo sapiens	90-95
25410780-2	2014	METHODS: The expression of Numb,MDM2 and p53 proteins in 65 cases of paired paraffin embedded pancreatic ductal adenocarcinoma (PDAC) specimens and adjacent non-cancerous pancreas was detected by immunohistochemistry (IHC).	Paraffin	76-84	NUMB endocytic adaptor protein	Homo sapiens	27-31
25009592-4	2014	Paraffin immunohistochemistry revealed: an exclusively cytoplasmic granular expression of ALK; CD138, immunoglobulin A (IgA) and CD79alpha positivity; and focal expression of multiple myeloma oncogene 1 (Mum-1), CD30 and epithelial membrane antigen (EMA).	Paraffin	0-8	ALK receptor tyrosine kinase	Homo sapiens	90-93
25009592-4	2014	Paraffin immunohistochemistry revealed: an exclusively cytoplasmic granular expression of ALK; CD138, immunoglobulin A (IgA) and CD79alpha positivity; and focal expression of multiple myeloma oncogene 1 (Mum-1), CD30 and epithelial membrane antigen (EMA).	Paraffin	0-8	TNF receptor superfamily member 8	Homo sapiens	212-216
24366835-5	2014	We examined Aurora B immunoreactivity in paraffin sections of 15 samples of Hodgkin lymphomas, obtained from 15 patients, 8 men and 7 women.	Paraffin	41-49	aurora kinase B	Homo sapiens	12-20
23993306-0	2014	A simple quantitative diagnostic alternative for MGMT DNA-methylation testing on RCL2 fixed paraffin embedded tumors using restriction coupled qPCR.	Paraffin	92-100	O-6-methylguanine-DNA methyltransferase	Homo sapiens	49-53
24346090-2	2014	METHODS: We developed a panel of single and multiplex RT-PCR assays suitable for rapid and accurate detection of the eight most common EML4-ALK+ variants and ALK gene expression in archival formalin-fixed, paraffin-embedded NSCLC specimens.	Paraffin	206-214	ALK receptor tyrosine kinase	Homo sapiens	158-161
24346090-11	2014	CONCLUSIONS: This panel of variant-specific, quantitative RT-PCR assays detects common EML4-ALK+ variants as well as ALK gene expression level in archival formalin-fixed paraffin-embedded NSCLC specimens.	Paraffin	170-178	ALK receptor tyrosine kinase	Homo sapiens	117-120
24097869-8	2013	Bisulfite next-generation sequencing mapping of the NAPRT1 promoter identified tumor-specific sites of NAPRT1 DNA methylation and enabled the development of a quantitative methylation-specific PCR (QMSP) assay suitable for use on archival formalin-fixed paraffin-embedded tumor tissue.	Paraffin	254-262	nicotinate phosphoribosyltransferase	Homo sapiens	52-58
24097869-11	2013	NAPRT1-specific immunohistochemical or DNA methylation assays can be used on archival formalin paraffin-embedded cancer tissue to identify patients likely to benefit from coadministration of a Nampt inhibitor and nicotinic acid.	Paraffin	95-103	nicotinate phosphoribosyltransferase	Homo sapiens	0-6
23731771-5	2013	PRUNE2 expression was detected using immunohistochemistry in 30 formalin-fixed, paraffin-embedded leiomyosarcoma tissues from MD Anderson Cancer Center, and high expression was detected in 36.7% (11/30) of the samples.	Paraffin	80-88	prune homolog 2 with BCH domain	Homo sapiens	0-6
24382242-2	2013	METHODS: The expression of DCLK1 was examined by immunohistochemical staining of paraffin-embedded tumor specimens from 122 patients who underwent curative gastrectomy for gastric cancer at Peking Union Medical College Hospital between July 2002 and December 2006.	Paraffin	81-89	doublecortin like kinase 1	Homo sapiens	27-32
23702732-4	2013	Utilizing the data set from our previously performed DNA microarray studies on formalin-fixed and paraffin-embedded tissue, we found that the genes C15orf48 and KRT9 had a distinct and robust gene expression pattern in distinguishing squamous cell carcinoma from pseudoepitheliomatous hyperplasia.	Paraffin	98-106	keratin 9	Homo sapiens	161-165
23907597-7	2013	These antibodies were further used to investigate by immunohistochemistry (IHC) SRAP location in paraffin-embedded breast tumors.	Paraffin	97-105	steroid receptor RNA activator 1	Homo sapiens	80-84
24433772-2	2013	METHODS: The expression of Gli1, MDM2 and p53 proteins in 57 paired paraffin embedded pancreatic ductal adenocarcinoma (PDAC) specimens and adjacent non-cancerous pancreatic tissues was detected by immunohistochemistry.	Paraffin	68-76	GLI family zinc finger 1	Homo sapiens	27-31
23977449-4	2013	A novel in situ hybridization method (RNAscope) was used to determine the transcript level of two relatively low expressed genes, CD44 and EpCAM in both individual formalin-fixed paraffin-embedded (FFPE) tissue sections and in an ESCC tissue microarray (TMA).	Paraffin	179-187	CD44 molecule (Indian blood group)	Homo sapiens	130-134
23564483-4	2013	PRX III expression was immunohistochemically determined in paraffin-embedded specimens from platinum-resistant (Pt-resistant) and platinum-sensitive (Pt-sensitive) patients.	Paraffin	59-67	peroxiredoxin 3	Homo sapiens	0-7
23606169-5	2013	RESULTS: Our study showed that PTC as low as 10% was good enough to detect KRAS G12D, G13D, and Q61L mutations in formalin-fixed paraffin-embedded (FFPE) material.	Paraffin	129-137	KRAS proto-oncogene, GTPase	Homo sapiens	75-79
23518916-4	2013	SOX2 immunoexpression was evaluated in 101 formalin-fixed, paraffin-embedded archival vulvar epithelia consisting of normal squamous vulvar epithelia (n=25), lichen sclerosus (n=9), high-grade classic vulvar intraepithelial neoplasia (HG-VIN, n=16), differentiated vulvar intraepithelial neoplasia (d-VIN, n=18), and vulvar invasive keratinizing SCC (n=33).	Paraffin	59-67	SRY-box transcription factor 2	Homo sapiens	0-4
23275449-0	2013	Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues.	Paraffin	160-168	C-type lectin domain containing 10A	Homo sapiens	125-132
23275449-0	2013	Protein domain histochemistry (PDH): binding of the carbohydrate recognition domain (CRD) of recombinant human glycoreceptor CLEC10A (CD301) to formalin-fixed, paraffin-embedded breast cancer tissues.	Paraffin	160-168	C-type lectin domain containing 10A	Homo sapiens	134-139
23275449-3	2013	Here, we describe the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues.	Paraffin	171-179	C-type lectin domain containing 10A	Homo sapiens	41-48
23275449-3	2013	Here, we describe the use of recombinant CLEC10A (CD301), a human glycoreceptor of the C-type lectin family, for the detection of ligands in sections from formalin-fixed, paraffin-embedded normal and cancerous mammary tissues.	Paraffin	171-179	C-type lectin domain containing 10A	Homo sapiens	50-55
23841222-4	2013	Here, we report the development of a matrix-assisted laser desorption/ionisation mass spectrometry imaging methodology for the study of EGFR, epiregulin and amphiregulin distribution in formalin fixed paraffin embedded human placental tissue and a comparison to expression patterns obtained by immunohiostochemistry.	Paraffin	201-209	amphiregulin	Homo sapiens	157-169
23573264-2	2013	METHODOLOGY/PRINCIPAL FINDINGS: In the present study, the methods of Western blotting and immunohistochemistry (IHC) were utilized to investigate the expression status of Beclin 1 and Bcl-xL in fresh ovarian tissues and paraffin-embedded epithelial ovarian tumor tissues.	Paraffin	220-228	beclin 1	Homo sapiens	171-179
23355875-7	2013	In 98 paraffin-embedded CRC tissues, KRAS codon 12 mutations were discovered in 28 (28.6%), significantly higher than that obtained by direct sequencing (13, 13.3%).	Paraffin	6-14	KRAS proto-oncogene, GTPase	Homo sapiens	37-41
22855160-4	2012	METHODS: RKIP expression was investigated retrospectively by immunohistochemistry in paraffin-embedded primary tumor tissue samples from a series (n = 99) of consecutive patients with pancreatic cancer.	Paraffin	85-93	phosphatidylethanolamine binding protein 1	Homo sapiens	9-13
22807173-2	2012	TCTP expression levels in kidneys, urinary bladder, and urethra were evaluated by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE) and Western blotting, and its cellular localization was examined immunohistochemically in paraffin sections of various urinary organs.	Paraffin	241-249	tumor protein, translationally-controlled 1	Rattus norvegicus	0-4
23161231-12	2012	In conclusion, evidence is presented that sending away paraffin blocks with tumor tissue for KRAS mutation testing may not be in the best interest of patients.	Paraffin	55-63	KRAS proto-oncogene, GTPase	Homo sapiens	93-97
22647537-3	2012	Here, we describe a validated immunohistochemical protocol for the detection of LC3 puncta in human formalin-fixed, paraffin-embedded cancer specimens that can also be applied to mouse tissues.	Paraffin	116-124	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	80-83
22228432-5	2012	We evaluated MGMT methylation status by methylation-specific PCR (MSP) in formalin-fixed and paraffin-embedded tumor specimens from 92 TNBC patients.	Paraffin	93-101	O-6-methylguanine-DNA methyltransferase	Homo sapiens	13-17
22665686-7	2012	For each patient, O(6)-methylguanine-DNA methyltransferase methylation status was investigated with genomic DNA from formalin-fixed or paraffin-embedded sections of tumour tissues by methylation-specific polymerase chain reaction.	Paraffin	135-143	O-6-methylguanine-DNA methyltransferase	Homo sapiens	18-58
22888635-5	2012	Detection of mutant K-RAS in DNA of clinical specimens (tumor tissues, formalin-fixed paraffin-embedded samples) reveals equal, at least, sensitivity of this method as compared with the HRMA and much higher as compared with Sanger sequencing.	Paraffin	86-94	KRAS proto-oncogene, GTPase	Homo sapiens	20-25
22058222-4	2012	Interleukin-17A-producing cells were analyzed in formalin-fixed, paraffin-embedded spleen and lymph node sections using immunohistochemistry and immunofluorescence.	Paraffin	65-73	interleukin 17A	Homo sapiens	0-15
21835426-8	2012	Thus, detection of the ASPSCR1-TFE3 fusion transcript was considered applicable for formalin-fixed, paraffin-embedded tissues with superior sensitivity as compared with TFE3 immunohistochemical staining.	Paraffin	100-108	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	23-30
22331132-11	2012	MDR3 immunostainings performed on formalin-fixed paraffin-embedded sections showed a strong canalicular staining in all patients except in one.	Paraffin	49-57	ATP binding cassette subfamily B member 4	Homo sapiens	0-4
22273571-4	2012	We conducted immunohistochemical studies on XIAP in formalin-fixed, paraffin-embedded sections from eight normal participants, 10 patients with Parkinson"s disease, five patients with dementia with Lewy bodies, and seven patients with Alzheimer"s disease, and then double-labeling immunohistochemistry for XIAP and HtrA2/Omi in sections from the Parkinson"s disease and dementia with Lewy bodies cases.	Paraffin	68-76	X-linked inhibitor of apoptosis	Homo sapiens	44-48
22358180-1	2012	A commentary on: analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma, by Lee et al.	Paraffin	131-139	KRAS proto-oncogene, GTPase	Homo sapiens	76-80
22661904-1	2012	Testing for mutations in the KRAS oncogene for patients with metastatic colorectal cancer (mCRC) is generally performed using DNA from formalin-fixed paraffin-embedded tumor tissue; however, access to specimens can be limited and analysis challenging.	Paraffin	150-158	KRAS proto-oncogene, GTPase	Homo sapiens	29-33
22031517-6	2012	They express the RET receptor and its GFRA2 coreceptor but also express the coreceptor GFRA3 that could be detected in the MZ of paraffin pituitary sections.	Paraffin	129-137	GDNF family receptor alpha 3	Homo sapiens	87-92
22530128-3	2012	In this paper, DNA promoter methylation of five C-terminal Ras-association family members (RASSF1A, RASSF2A, RASSF4, RASSF5, and RASSF6) was studied in 64 formalin-fixed paraffin-embedded (FFPE) bladder cancer and normal adjacent tissues using methylation-specific high-resolution melting (MS-HRM) analysis.	Paraffin	170-178	Ras association domain family member 1	Homo sapiens	91-98
23461062-5	2012	Expression levels of JWA protein in archival 292 formalin-fixed, paraffin-embedded specimens were also analyzed by immunohistochemistry.	Paraffin	65-73	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	21-24
22848668-5	2012	Immunohistochemistry was used to examine the expression of the M2-specific antigen CD163 in paraffin-embedded mammary carcinoma blocks to explore fusion events in breast cancer patients.	Paraffin	92-100	CD163 molecule	Homo sapiens	83-88
22396748-5	2012	N1-8 monoclonal antibody provided the best recognition of RB1CC1 in the clinico-pathological examination of formalin-fixed paraffin-embedded tissues.	Paraffin	123-131	RB1 inducible coiled-coil 1	Homo sapiens	58-64
22083191-0	2011	[High-throughput screening method of KRAS mutations at codons 12 and 13 in formalin-fixed paraffin-embedded tissue specimens of metastatic colorectal cancer].	Paraffin	90-98	KRAS proto-oncogene, GTPase	Homo sapiens	37-41
22083191-6	2011	We demonstrated the KRAS mutation status in paraffin-embedded tissues of mCRC and confirmed that the results were comparable to those of the direct sequencing method.	Paraffin	44-52	KRAS proto-oncogene, GTPase	Homo sapiens	20-24
21873938-3	2011	MATERIAL/METHODS: Eph-A2 and Eph-A4 protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 131 patients with benign and malignant lesions.	Paraffin	93-101	EPH receptor A4	Homo sapiens	29-35
21181234-4	2011	We have developed a primer extension-based assay adapted to formalin-fixed paraffin-embedded tissues that enables quantitative assessment of the methylation status of the MGMT promoter.	Paraffin	75-83	O-6-methylguanine-DNA methyltransferase	Homo sapiens	171-175
21076843-4	2011	METHODS: The expression of RECK, MMP-2, and MMP-9 in paraffin sections of hamster and human CCA specimens was analyzed by immunohistochemistry.	Paraffin	53-61	matrix metallopeptidase 9	Homo sapiens	44-49
21167898-6	2011	Moreover, using immunohistochemistry on paraffin-embedded colonic tissue sections, we could show a co-localisation of DMBT1 and galectin 3 in human intestine, suggesting a potential physiological interaction.	Paraffin	40-48	deleted in malignant brain tumors 1	Homo sapiens	118-123
20556478-2	2011	In the present study, we determined the status of MGMT using methylation-specific polymerase chain reaction (PCR) and immunohistochemistry on paraffin-embedded specimens in 12 human gliosarcomas, and these results were then related to overall survival (OS) and response to alkylating agents.	Paraffin	142-150	O-6-methylguanine-DNA methyltransferase	Homo sapiens	50-54
20603439-3	2011	PATIENTS AND METHODS: we assessed BRCA1 messenger RNA expression levels in paraffin-embedded pre-treatment tumor samples obtained by transurethral resection from 57 patients with locally advanced bladder cancer subsequently treated with neoadjuvant cisplatin-based chemotherapy.	Paraffin	75-83	BRCA1 DNA repair associated	Homo sapiens	34-39
22820140-2	2011	We evaluated immunohistochemical expression of MMP-2 and TIMP-2 in paraffin sections of 12 human fetal thyroids at mid-term gestation and 79 thyroid tumors of follicular origin.	Paraffin	67-75	TIMP metallopeptidase inhibitor 2	Homo sapiens	57-63
21686179-0	2011	KRAS mutation detection in paired frozen and Formalin-Fixed Paraffin-Embedded (FFPE) colorectal cancer tissues.	Paraffin	60-68	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
21030527-0	2011	Sensitive multiplex detection of KRAS codons 12 and 13 mutations in paraffin-embedded tissue specimens.	Paraffin	68-76	KRAS proto-oncogene, GTPase	Homo sapiens	33-37
21030527-3	2011	AIMS: To evaluate a novel multiplex assay for the rapid detection of common KRAS mutations in formalin-fixed paraffin-embedded (FFPE) tissues.	Paraffin	109-117	KRAS proto-oncogene, GTPase	Homo sapiens	76-80
21051833-2	2010	METHODS: Envision Tm immunohistochemistry was used to detect the expression level of CHK1 and PLK1 in conventional paraffin-embedded sections from specimens of primary foci (n=59)and metastatic foci of lymph node (n=42) of gastric cancer, peritumoral tissues (n=20), and benign lesions of the stomach (n=95).	Paraffin	115-123	polo like kinase 1	Homo sapiens	94-98
20734373-7	2010	Utility of the system was further demonstrated by detecting K-ras gene mutations in paraffin tissue sections from two colorectal cancer patients.	Paraffin	84-92	KRAS proto-oncogene, GTPase	Homo sapiens	60-65
20454888-5	2010	This was confirmed both by immunohistochemical staining of CD68-Fc-treated paraffin sections from human plaques and by ELISA-based quantification of CD68-Fc binding to human atherosclerotic plaque extracts.	Paraffin	75-83	CD68 molecule	Homo sapiens	59-63
20482381-9	2010	CONCLUSIONS: A novel, qualitative, sensitive, reliable and high throughput liquidchip technology has been developed for detecting KRAS mutations using clinical serum and formalin-fixed and paraffin-embedded samples.	Paraffin	189-197	KRAS proto-oncogene, GTPase	Homo sapiens	130-134
20868591-2	2010	METHOD: The expression of IGF-1R was detected in 39 paraffin-embedded chemotherapy-naive non-small cell lung cancer tumor samples with immunohistochemical method,and the relationship between the outcomes of platinum-based chemotherapy and IGF-1R expression was analyzed.	Paraffin	52-60	insulin like growth factor 1 receptor	Homo sapiens	26-32
20471559-2	2010	This study was conducted to evaluate the expression of p35 and syndecan-1 in 43 paraffin-embedded tissue specimens of OLP according to streptavidin-biotin technique and to investigate the possible association that might exist between such expression and the clinicopathologic types of OLP as well as some risk cofactors such as hepatitis C viral (HCV) infection among Egyptian population.	Paraffin	80-88	interleukin 12A	Homo sapiens	55-58
20557670-4	2010	Patients with acute B-ALL (22 cases) and AML (57 cases) were examined using immunohistochemistry for LMO2 on paraffin-embedded bone marrow biopsies.	Paraffin	109-117	LIM domain only 2	Homo sapiens	101-105
20204293-6	2010	Immunohistochemical expression of GLUT-1 was studied in paraffin sections of tumors using anti-GLUT-1 antibodies and GLUT-1 expression scores were derived based on staining intensities.	Paraffin	56-64	solute carrier family 2 member 1	Homo sapiens	34-40
20132187-3	2010	CAR protein expression was assessed immunohistochemically on paraffin-embedded thyroid tissues from 107 patients with benign and malignant lesions and was statistically analyzed in relation to histopathologic type; tumor size; lymph node metastasis; capsular, lymphatic and vessel invasion; as well as follicular cells" proliferative capacity.	Paraffin	61-69	CXADR Ig-like cell adhesion molecule	Homo sapiens	0-3
20093389-0	2010	Mutation detection of epidermal growth factor receptor and KRAS genes using the smart amplification process version 2 from formalin-fixed, paraffin-embedded lung cancer tissue.	Paraffin	139-147	KRAS proto-oncogene, GTPase	Homo sapiens	59-63
20081804-11	2010	Thus, sphingosine-1-phosphate receptor 1 immunohistochemistry may be useful in the histological diagnosis of mantle cell lymphoma with formalin-fixed and paraffin-embedded sections.	Paraffin	154-162	sphingosine-1-phosphate receptor 1	Homo sapiens	6-40
20429312-2	2010	METHODS: The expression of MCM-2 and Ki-67 on paraffin-embedded tumor tissue sections of patients with invasive breast carcinoma was analyzed immunohistochemically.	Paraffin	46-54	minichromosome maintenance complex component 2	Homo sapiens	27-32
19963137-0	2010	Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues.	Paraffin	85-93	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	23-26
19963137-0	2010	Fusion of HMGA1 to the LPP/TPRG1 intergenic region in a lipoma identified by mapping paraffin-embedded tissues.	Paraffin	85-93	tumor protein p63 regulated 1	Homo sapiens	27-32
19963137-5	2010	Molecular cytogenetic mapping of available paraffin-embedded tissues revealed the fusion of HMGA1 to a 139-kb genomic region between the LPP and TPRG1 loci.	Paraffin	43-51	LIM domain containing preferred translocation partner in lipoma	Homo sapiens	137-140
22072121-4	2010	For this first Tunisian study on KRAS, we detected 45.83% of altered KRAS gene among 48 formalin-fixed paraffin-embedded sporadic colorectal adenocarcinoma patients.	Paraffin	103-111	KRAS proto-oncogene, GTPase	Homo sapiens	33-37
22072121-4	2010	For this first Tunisian study on KRAS, we detected 45.83% of altered KRAS gene among 48 formalin-fixed paraffin-embedded sporadic colorectal adenocarcinoma patients.	Paraffin	103-111	KRAS proto-oncogene, GTPase	Homo sapiens	69-73
20390900-1	2010	In the present study the catalytic oxidation of an industrial organic solvent consisting predominantly of C-9 to C-10 paraffins and napthtenics and derived from low aromatic white spirit on CuO and Pt catalysts was investigated at ambient pressure and temperatures between 330 and 770 K. Catalysts were prepared in the laboratory and compared to commercial ones.	Paraffin	118-127	complement C9	Homo sapiens	106-109
20007845-10	2010	We conclude that coring of the paraffin blocks and testing by ARMS/S is a sensitive, specific, and efficient method for KRAS testing.	Paraffin	31-39	KRAS proto-oncogene, GTPase	Homo sapiens	120-124
20388394-2	2010	METHODS: Expression of co-stimulators CD86 and inducible co-stimulator (ICOS) was studied by immunohistochemistry on paraffin-embedded mucosal tissue from patients with active UC (64 cases), inactive UC (51 cases) and normal controls (20 cases).	Paraffin	117-125	inducible T cell costimulator	Homo sapiens	72-76
20019769-2	2009	METHODS: Expression of co-stimulator CD86 and ICOS was examined by immunohistochemistry on paraffin embedded tissue from patients with CD (30 cases) and normal controls (20 cases).	Paraffin	91-99	inducible T cell costimulator	Homo sapiens	46-50
19783717-2	2009	This study aimed to perform KRAS mutation detection on formalin-fixed paraffin-embedded (FFPE) tumour tissue by two different methods for comparison.	Paraffin	70-78	KRAS proto-oncogene, GTPase	Homo sapiens	28-32
19784367-4	2009	MATERIALS AND METHODS: Nuclear PARP-1 immunohistochemical expression was studied in 326 paraffin-embedded renal allograft biopsies (193 with different degrees of ATN and 133 controls) and in murine Parp-1 knockout model of IR injury.	Paraffin	88-96	poly (ADP-ribose) polymerase family, member 1	Mus musculus	31-37
19609206-0	2009	RT-PCR analysis for FGF23 using paraffin sections in the diagnosis of phosphaturic mesenchymal tumors with and without known tumor induced osteomalacia.	Paraffin	32-40	fibroblast growth factor 23	Homo sapiens	20-25
19820381-6	2009	Reverse transcriptase polymerase chain reaction analysis from paraffin-embedded tissue revealed EWS-FLI1 fusion product in 1 case.	Paraffin	62-70	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	100-104
19656999-2	2009	MATERIALS AND METHODS: The O(6)-methylguanine-DNA methyltransferase (MGMT) status was evaluated by methylation-specific PCR (MSP), immunohistochemistry and Western blotting analysis in formalin-fixed paraffin-embedded surgical samples.	Paraffin	200-208	O-6-methylguanine-DNA methyltransferase	Homo sapiens	27-67
19656999-2	2009	MATERIALS AND METHODS: The O(6)-methylguanine-DNA methyltransferase (MGMT) status was evaluated by methylation-specific PCR (MSP), immunohistochemistry and Western blotting analysis in formalin-fixed paraffin-embedded surgical samples.	Paraffin	200-208	O-6-methylguanine-DNA methyltransferase	Homo sapiens	69-73
19324993-0	2009	A rapid and reliable test for BRCA1 and BRCA2 founder mutation analysis in paraffin tissue using pyrosequencing.	Paraffin	75-83	BRCA1 DNA repair associated	Homo sapiens	30-35
19324993-0	2009	A rapid and reliable test for BRCA1 and BRCA2 founder mutation analysis in paraffin tissue using pyrosequencing.	Paraffin	75-83	BRCA2 DNA repair associated	Homo sapiens	40-45
19324993-8	2009	We show that pyrosequencing is a rapid and reliable method that serves as an excellent platform for BRCA founder mutation analysis, especially when only paraffin-embedded tissues are available.	Paraffin	153-161	BRCA1 DNA repair associated	Homo sapiens	100-104
19385591-5	2009	One hundred and forty-six primary operable breast cancer patients were investigated in order to identify the population of CD44+ and Bcl-2+ cells in paraffin-embedded tissues by immunohistochemistry.	Paraffin	149-157	CD44 molecule (Indian blood group)	Homo sapiens	123-127
19358724-4	2009	METHODS: The presence of KRAS mutations in codon 12 and 13 was analyzed in frozen and formalin-fixed paraffin-embedded (FFPE) tissue with a low density biochip platform.	Paraffin	101-109	KRAS proto-oncogene, GTPase	Homo sapiens	25-29
26622835-4	2015	In the present study, the TRIM29 expression status was investigated by immunohistochemical analysis in paraffin-embedded specimens obtained from 320 patients with surgically resected NSCLC, treated between 2000 and 2007.	Paraffin	103-111	tripartite motif containing 29	Homo sapiens	26-32
19258541-6	2009	Immunohistochemical analysis of archival paraffin-embedded adult premenopausal human breast tissue specimens identified a significantly lower level of expression of STAT1 (P &lt; 0.05, Mann-Whitney U test) in parous compared with age-matched nulliparous tissue (median of 24% compared with 42% epithelial cells positive).	Paraffin	41-49	signal transducer and activator of transcription 1	Homo sapiens	165-170
26311741-3	2015	SPHK1 expression was examined in 287 formalin-fixed, paraffin-embedded cervical cancer tissues using immunohistochemistry, and its clinical implications and prognostic significance were analyzed.	Paraffin	53-61	sphingosine kinase 1	Homo sapiens	0-5
18465232-3	2009	Immunohistochemical expression of MCM-2 and MCM-5 was performed on paraffin-embedded malignant tissue sections obtained from 96 patients with colon cancer.	Paraffin	67-75	minichromosome maintenance complex component 2	Homo sapiens	34-39
26037795-3	2015	METHODS: PD-L1 expression (cutoff 5%) was analyzed by immunohistochemistry with two different antibodies in BRAF(V600)-mutated formalin-fixed and paraffin-embedded samples from 80 consecutive MMP treated with BRAFi at a single institution.	Paraffin	146-154	CD274 molecule	Homo sapiens	9-14
19489224-2	2009	METHODS: The expression of KAI1 gene was studied by immunohistochemistry for CD82 on paraffin-embedded tumor tissues.	Paraffin	85-93	CD82 molecule	Homo sapiens	27-31
26159303-4	2015	Immunohistochemistry staining was used to detect the expression of Paxillin in 242 samples of paraffin-embedded tissues.	Paraffin	94-102	paxillin	Homo sapiens	67-75
19130735-1	2008	OBJECTIVE: To analyze the reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded (FFPE) neurosurgical biopsy specimens.	Paraffin	183-191	O-6-methylguanine-DNA methyltransferase	Homo sapiens	127-131
18802756-5	2008	These data provide evidence that the best detection of nNOS in paraffin sections is obtained using immersion fixation in Carnoy"s fluid or post-fixation in this solution after perfusion with 4% paraformaldehyde.	Paraffin	63-71	nitric oxide synthase 1	Rattus norvegicus	55-59
25893809-1	2015	To examine the relationship between cytotoxic T lymphocyte antigen 4 (CTLA-4) expression and breast cancer prognosis, CTLA-4 expression was immunohistochemically detected in paraffin-embedded specimens of primary tumors from 130 patients with breast cancer who had a mean follow-up period of 112 months.	Paraffin	174-182	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	118-124
18652761-2	2008	ANXA1 expression was examined by immunohistochemistry in paraffin-embedded cervical tissue samples (n = 234), comprising 52 samples of normal cervical epithelia, 30 of cervical intraepithelial neoplasia (CIN) I, 27 of CIN II, 32 of CIN III, and 93 of invasive squamous cell carcinoma (ISCC).	Paraffin	57-65	annexin A1	Homo sapiens	0-5
25707853-6	2015	Among the four antibodies we developed, the antibody that targeted Girdin when phosphorylated at Y1798 (pY1798) worked well for immunohistochemistry of paraffin-embedded tissues as well as for cultured cells.	Paraffin	152-160	coiled-coil domain containing 88A	Homo sapiens	67-73
18556773-2	2008	Stratified therapy assignment of patients in prospective clinical trials according to tumor MGMT status requires a standardized diagnostic test, suitable for high-throughput analysis of small amounts of formalin-fixed, paraffin-embedded tumor tissue.	Paraffin	219-227	O-6-methylguanine-DNA methyltransferase	Homo sapiens	92-96
25411978-3	2015	Immunohistochemical analysis of PKM2 expression was carried out in paraffin-embedded sections of pancreatic cancer tissue.	Paraffin	67-75	pyruvate kinase M1/2	Homo sapiens	32-36
18410580-4	2008	The expression of FAS was determined by the standard immunoperoxidase technique in formalin-fixed and paraffin-embedded specimens and correlated with the clinicopathological characteristics of the tumors.	Paraffin	102-110	fatty acid synthase	Homo sapiens	18-21
25658620-9	2015	Similarly, EIF4EBP1 protein is notably upregulated in 8 HCC tissues (randomly selected from the 40 HCCs) measured by Western blot and is significantly increased in another 88 paraffin-embedded HCCs (53%, 47/88) by immunohistochemistry compared with the matched NCLs (P &lt; 0.001).	Paraffin	175-183	eukaryotic translation initiation factor 4E binding protein 1	Homo sapiens	11-19
18575327-2	2008	METHODS: The expressions of KAI1 protein in the formalin-fixed, paraffin-embedded specimens of 20 normal cervical epthelium, 15 cervical in situ carcinoma and 70 primary invasive cervical carcinoma were detected by immunohistochemistry SP.	Paraffin	64-72	CD82 molecule	Homo sapiens	28-32
18347292-7	2008	Fluorescence in situ hybridization analysis of paraffin-embedded tissue revealed a BCR-ABL fusion, indicating the presence of t(9;22)(q34;q11).	Paraffin	47-55	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	83-90
25427744-4	2015	CEACAM6 epitope recognized by AP11 was well preserved in formalin-fixed and paraffin-embedded tissues.	Paraffin	76-84	CEA cell adhesion molecule 6	Homo sapiens	0-7
18300343-5	2008	Finally, PK2/Bv8 protein was detected in normal liver paraffin sections and in isolated liver cells by immunohistochemistry and immunocytochemistry.	Paraffin	54-62	prokineticin 2	Homo sapiens	9-12
18300343-5	2008	Finally, PK2/Bv8 protein was detected in normal liver paraffin sections and in isolated liver cells by immunohistochemistry and immunocytochemistry.	Paraffin	54-62	prokineticin 2	Homo sapiens	13-16
25951497-10	2015	Upregulation of miR-21 and miR-146a was also detected in formalin-fixed, paraffin-embedded UM, suggesting that VH or serum alterations in UM could be the consequence of disregulation arising from tumoral cells.	Paraffin	73-81	microRNA 21	Homo sapiens	16-22
18172263-0	2008	Identification of patients with (atypical) MUTYH-associated polyposis by KRAS2 c.34G &gt; T prescreening followed by MUTYH hotspot analysis in formalin-fixed paraffin-embedded tissue.	Paraffin	158-166	mutY DNA glycosylase	Homo sapiens	43-48
25951497-10	2015	Upregulation of miR-21 and miR-146a was also detected in formalin-fixed, paraffin-embedded UM, suggesting that VH or serum alterations in UM could be the consequence of disregulation arising from tumoral cells.	Paraffin	73-81	microRNA 146a	Homo sapiens	27-35
25214475-8	2015	ZNF165 protein expression was demonstrated on archival formalin-fixed, paraffin-embedded (FFPE) bladder tissues using IHC and nuclear staining pattern was detected.	Paraffin	71-79	zinc finger protein 165	Homo sapiens	0-6
18257228-7	2007	The results of immunohistochemistry on whole-mount embryo and paraffin section demonstrated that KCTD10 is highly expressed in neuroepithelium of neural tube and dorsal root ganglion of 12.5 d embryos.	Paraffin	62-70	potassium channel tetramerisation domain containing 10	Mus musculus	97-103
17786470-4	2007	We also examined the expression and distribution of MUC18 in paraffin sections of primary uveal melanomas (n = 23; 5/23 spindle; 18/23 mixed and epithelioid) and normal eyes (n = 3) using a polyclonal goat anti-human antibody to MUC18 visualized with peroxidase and Vector NovaRED.	Paraffin	61-69	melanoma cell adhesion molecule	Homo sapiens	52-57
25766605-3	2015	Therefore, we surveyed these TLR4 SNPs by using formalin-fixed and paraffin-embedded tissue blocks obtained from autopsies of patients with invasive pulmonary aspergillosis.	Paraffin	67-75	toll like receptor 4	Homo sapiens	29-33
17764575-3	2007	METHODS: The clinical relevance of 14-3-3zeta protein in oral tumorigenesis was determined by immunohistochemistry in paraffin embedded sections of oral pre-malignant lesions (OPLs), OSCCs and histologically normal oral tissues and corroborated by Western Blotting.	Paraffin	118-126	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	35-45
17721195-11	2007	In conclusion, FUS-CREB3L1/L2 fusion transcripts can be detected in paraffin-embedded LGFMS in a sensitive manner, using reverse transcription-polymerase chain reaction.	Paraffin	68-76	cAMP responsive element binding protein 3 like 1	Homo sapiens	19-26
17636064-3	2007	METHODS: tPA and von Willebrand factor (vWF), a vascular endothelial cell marker, are detected on vascular endothelium by immunoperoxidase methods with specific antibodies on formalin fixed paraffin embedded sural nerve biopsies from six diabetic and six axonal neuropathy control nerves without vasculopathy.	Paraffin	190-198	chromosome 20 open reading frame 181	Homo sapiens	9-12
25444499-3	2014	Our objective was to investigate the clinicopathological contribution of the miR-148a expression in HCC formalin-fixed paraffin-embedded (FFPE) tissues.	Paraffin	119-127	microRNA 148a	Homo sapiens	77-85
17559122-4	2007	METHODS: STAT1 expression and subcellular localization was examined immunohistochemically on a tissue microarray of paraffin-embedded tumor specimens from 89 patients who underwent surgical treatment in the period between 1980 and 1997.	Paraffin	116-124	signal transducer and activator of transcription 1	Homo sapiens	9-14
25182852-4	2014	The expression of HuR and estrogen receptor alpha (ER-alpha) protein was examined by immunohistochemistry on paraffin embedding specimens containing endometrial carcinoma and adjacent non-cancerous tissues.	Paraffin	109-117	ELAV like RNA binding protein 1	Homo sapiens	18-21
17592274-9	2007	In conclusion, this study shows that neoplastic AITL CXCL13 T cells localize in the skin and that accurate diagnosis of AITL lesions can be done in skin specimens using CXCL13 immunostaining on paraffin-embedded tissues.	Paraffin	194-202	C-X-C motif chemokine ligand 13	Homo sapiens	169-175
24958785-3	2014	METHOD: CD200 expression was studied in 77 cases of PCM by immunohistochemistry on paraffin sections from decalcified bone marrow biopsies.	Paraffin	83-91	CD200 molecule	Homo sapiens	8-13
17695545-3	2007	MATERIALS AND METHODS: Tumour messenger RNA (mRNA) of the KiSS1 exon I/II boundary was extracted from paraffin-embedded stage II or III node-positive breast adenocarcinomas of 272 women.	Paraffin	102-110	KiSS-1 metastasis suppressor	Homo sapiens	58-63
25267951-3	2014	METHODS: The methylation of CTLA4 gene promoter was evaluated by methylation-specific polymerase chain reaction (MSP) technique using 85 paraffin-embedded gastric cancer tissue samples and normal tissue on the tumor margins as control tissue samples.	Paraffin	137-145	cytotoxic T-lymphocyte associated protein 4	Homo sapiens	28-33
17591937-9	2007	The optimized pyrosequencing assay performed best and provides a sensitive, robust, and easy-to-use method for quantitative assessment of MGMT methylation, for both snap-frozen and paraffin-embedded specimens.	Paraffin	181-189	O-6-methylguanine-DNA methyltransferase	Homo sapiens	138-142
17543078-0	2007	Detection of the ASPSCR1-TFE3 gene fusion in paraffin-embedded alveolar soft part sarcomas.	Paraffin	45-53	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	17-24
17473196-10	2007	CONCLUSIONS: Whereas the collection of fresh-frozen tumor samples remains a major challenge in large clinical trials, routinely processed paraffin-embedded tissue samples can be used to quantitate the prognostic biological markers trkC and c-myc.	Paraffin	138-146	neurotrophic receptor tyrosine kinase 3	Homo sapiens	231-235
25536568-14	2014	Consequently the I-FISH method allows identification of of MYC and IGH gene rearrangements in tissue cells substrate of lymphoma fixed in paraffin.	Paraffin	138-146	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	59-62
17367612-0	2007	Immunohistochemical staining for CD45R isoforms in paraffin sections to diagnose mycosis fungoides-type cutaneous T-cell lymphoma.	Paraffin	51-59	protein tyrosine phosphatase receptor type C	Homo sapiens	33-38
25070653-8	2014	Analysis of eIF3a expression in primary formalin-fixed paraffin embedded UBC samples of 198 patients revealed that eIF3a up-regulation corresponds to tumour grade and that high eIF3a expression corresponds to longer overall survival rates of patients with low grade tumours.	Paraffin	55-63	eukaryotic translation initiation factor 3 subunit J	Homo sapiens	12-17
17465211-9	2007	CONCLUSION: The DPD mRNA level and OPRT/DPD ratio evaluated from paraffin embedded specimens are candidates for further evaluation as predictors of response against 5-fluorouracil-based chemotherapy in colorectal cancer.	Paraffin	65-73	dihydropyrimidine dehydrogenase	Homo sapiens	16-19
24919811-3	2014	In the present study, the expression of Notch3 in HCC and adjacent non-neoplastic tissue was immunohistochemically assessed on formalin-fixed, paraffin-embedded sections.	Paraffin	143-151	notch receptor 3	Homo sapiens	40-46
17337387-14	2007	The COL1A1-PDGFB fusion gene is detectable either by multiplex RT-PCR with a combination of forward primers designed from a variety of COL1A1 exons and one reverse primer for PDGFB exon 2, or by in situ fluorescence hybridization (FISH) on interphase nuclei from frozen or fixed paraffin-embbeded sections.	Paraffin	279-287	collagen type I alpha 1 chain	Homo sapiens	4-10
17337387-14	2007	The COL1A1-PDGFB fusion gene is detectable either by multiplex RT-PCR with a combination of forward primers designed from a variety of COL1A1 exons and one reverse primer for PDGFB exon 2, or by in situ fluorescence hybridization (FISH) on interphase nuclei from frozen or fixed paraffin-embbeded sections.	Paraffin	279-287	platelet derived growth factor subunit B	Homo sapiens	11-16
24977712-4	2014	Expression of TLR4 and MyD88 was assessed immunohistochemically in 198 paraffin-embedded ovarian tissues and in an embryonal carcinoma model of cancer stemness.	Paraffin	71-79	toll like receptor 4	Homo sapiens	14-18
25120807-0	2014	Association between mir-24 and mir-378 in formalin-fixed paraffin-embedded tissues of breast cancer.	Paraffin	57-65	microRNA 378a	Homo sapiens	31-38
18376796-5	2006	CD44 expression was detected using a standard immunoperoxidase method on formalin-fixed, paraffin-embedded, primary infiltrating ductal breast carcinoma tissues taken from 60 female patients who underwent mastectomy with axillary node clearance.	Paraffin	89-97	CD44 molecule (Indian blood group)	Homo sapiens	0-4
25031739-4	2014	Wnt-5a and beta-catenin protein expression was detected by immunohistochemical staining of paraffin-embedded tissues of 85 cases of HCC and corresponding para-carcinoma tissues and 15 cases of hepatic cirrhosis.	Paraffin	91-99	catenin beta 1	Homo sapiens	11-23
17034813-0	2006	Simultaneous detection of a cell surface antigen and apoptosis by microwave-sensitized TUNEL assay on paraffin sections.	Paraffin	102-110	CD53 molecule	Homo sapiens	28-48
16949936-3	2006	In this study, detection of expression of syndecan-1 protein and Epstein-Barr virus-encoded latent membrane protein-1 (LMP-1) in primary, recurrent, and metastatic NPC specimens in paraffin sections was performed by immunohistochemistry.	Paraffin	181-189	PDZ and LIM domain 7	Homo sapiens	119-124
24176776-3	2014	PTTG protein expression was analyzed in 108 archived, paraffin-embedded primary ESCC specimens by immunohistochemistry and correlated with clinicopathological parameters and patients" outcome.	Paraffin	54-62	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	0-4
16735593-3	2006	For that purpose, paraffin-embedded tissue blot (PET-blot) method was applied on brains from C57Bl/6 mice infected with cattle BSE, experimental sheep BSE, or feline spongiform encephalopathy (FSE) from a cheetah.	Paraffin	18-26	thyroid stimulating hormone receptor	Mus musculus	49-52
16934020-6	2006	MAbs 7C2 and 9E11 stained the IGF- 1R on frozen or paraffin-embedded tissue sections or frozen cells.	Paraffin	51-59	insulin like growth factor 1 receptor	Homo sapiens	30-37
26202506-5	2014	RESULTS: Increased Nbs1 expression was observed in tumor compared to corresponding adjacent non-tumor tissue in 54.6 and 47.3 % of HCC cases detected with frozen tissues and paraffin sections.	Paraffin	174-182	nibrin	Homo sapiens	19-23
16827667-4	2006	The presence of CD34 mRNA and glycoprotein was assessed on formalin-fixed, paraffin-embedded canine skin samples by in situ hybridization technique and by standard immunohistochemistry, respectively.	Paraffin	75-83	CD34 molecule	Canis lupus familiaris	16-20
24051693-10	2014	Furthermore, miR-31 is universally expressed in both ulcerative colitis and Crohn disease not only in fresh-frozen but also in formalin-fixed, paraffin-embedded tissues.	Paraffin	143-151	microRNA 31	Homo sapiens	13-19
16784991-5	2006	The expression of N-cadherin was examined by immunohistochemistry using archive material and a mouse anti-N-cadherin monoclonal antibody previously shown to react in routinely processed paraffin-embedded tissues.	Paraffin	186-194	cadherin 2	Homo sapiens	18-28
24603753-7	2014	Scoring guidelines to aid in the evaluation of ERCC1 tumor expression were developed and evaluated in archival formalin-fixed paraffin embedded colorectal cancer specimens.	Paraffin	126-134	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	47-52
16819153-3	2006	In the present study, we employed a sensitive, reliable immunohistochemical detection system for N-cadherin on formalin-fixed, paraffin-embedded tissue sections, and succeeded in demonstrating N- and E-cadherin protein expressions and their distribution in normal human tissues.	Paraffin	127-135	cadherin 2	Homo sapiens	97-107
16819153-8	2006	The method presented here should prove useful for the further investigation of the N-cadherin expression and function in several disease conditions on formalin-fixed, paraffin-embedded archival tissues.	Paraffin	167-175	cadherin 2	Homo sapiens	83-93
24790510-6	2014	Paraffin blocks were stained with E-selectin and P-cadherin in accordance with the procedure.	Paraffin	0-8	selectin E	Homo sapiens	34-44
16789720-5	2006	Antibodies against platelet GP IIIa were demonstrated to be the most useful for the diagnosis of megakaryoblastic leukemia of paraffin-embedded canine tissues.	Paraffin	126-134	integrin beta-3	Canis lupus familiaris	28-35
16784656-5	2006	RESULTS: (1) On proliferation-related gene proteins, the expression of PCNA, Ki-67, cyclin D1 was significantly decreased, with significantly increased expression of p27 protein, in paraffin sections of NCTD group when compared with control group (P &lt; 0.05); The expression of PCNA mRNA, cyclin D1 mRNA was decreased, with significantly increased expression of p27 mRNA in NCTD group.	Paraffin	182-190	proliferating cell nuclear antigen	Mus musculus	71-75
16784656-5	2006	RESULTS: (1) On proliferation-related gene proteins, the expression of PCNA, Ki-67, cyclin D1 was significantly decreased, with significantly increased expression of p27 protein, in paraffin sections of NCTD group when compared with control group (P &lt; 0.05); The expression of PCNA mRNA, cyclin D1 mRNA was decreased, with significantly increased expression of p27 mRNA in NCTD group.	Paraffin	182-190	cyclin-dependent kinase inhibitor 1B	Mus musculus	166-169
16784656-8	2006	On metastasis-related gene proteins, the expression of nm23 and TIMP2 was significantly increased, with significantly decreased expression of MMP2 in paraffin sections of NCTD group when compared with control group (P &lt; 0.05); The expression of nm23-H1 mRNA, TIMP2 mRNA was significantly increased, with significantly decreased expression of MMP2 mRNA in NCTD group.	Paraffin	150-158	matrix metallopeptidase 2	Mus musculus	142-146
16435376-3	2006	METHODS: Immunohistochemical staining for GLUT-1 was performed on paraffin-embedded cell blocks of 28 cases with the following cytologic diagnoses: 1) metastatic SCC (11 cases); 2) atypical squamous cells, SCC [corrected] cannot be excluded (6 cases); and 3) cytologic findings consistent with branchial cleft cyst (BCC) (11 cases).	Paraffin	66-74	solute carrier family 2 member 1	Homo sapiens	42-48
24502396-3	2014	Since detection of tumor CD26 expression is required for determining potential eligibility for YS110 therapy, the development of anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in the formalin-fixed paraffin-embedded tissues is critical.	Paraffin	236-244	dipeptidyl peptidase 4	Homo sapiens	140-144
24502396-3	2014	Since detection of tumor CD26 expression is required for determining potential eligibility for YS110 therapy, the development of anti-human CD26 mAb that can clearly and reliably detect the denatured CD26 molecule in the formalin-fixed paraffin-embedded tissues is critical.	Paraffin	236-244	dipeptidyl peptidase 4	Homo sapiens	140-144
16541434-9	2006	MGMT protein expression was estimated semiquantitatively by immunohistochemistry using paraffin embedded tumor sections.	Paraffin	87-95	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-4
24721346-2	2014	METHODS: The expression of LIF protein in 53 paired paraffin-embedded PDAC specimens and adjacent non-cancerous pancreatic tissues were detected by immunohistochemistry.	Paraffin	52-60	LIF interleukin 6 family cytokine	Homo sapiens	27-30
16405664-4	2006	Immunohistochemical staining for p62 was performed on 73 cases of paraffin-embedded prostatic tissue.	Paraffin	66-74	sequestosome 1	Homo sapiens	33-36
24183365-2	2014	Immunohistochemical analysis of PSCA expression was performed on tissue microarrays of 185 paraffin-embedded tissues of Iranian patients, including 114 prostate cancers (PCa), 21 High Grade Prostatic Intraepithelial Neoplasias (HGPIN) and 50 samples of benign prostate tissue.	Paraffin	91-99	prostate stem cell antigen	Homo sapiens	32-36
16046671-0	2006	Genetic immunization: a new monoclonal antibody for the detection of BCL-6 protein in paraffin sections.	Paraffin	86-94	BCL6 transcription repressor	Homo sapiens	69-74
16116035-5	2006	Nonradioactive in situ hybridization applied on paraffin tissue sections from 26 colon cancer patients revealed barely detected SAA mRNA expression in normal looking colonic epithelium.	Paraffin	48-56	serum amyloid A1 cluster	Homo sapiens	128-131
24193004-6	2013	We here propose a method for hERG1 gene quantification in colorectal cancer samples in both cryopreserved and formalin-fixed and paraffin-embedded samples.	Paraffin	129-137	potassium voltage-gated channel subfamily H member 2	Homo sapiens	29-34
16532965-0	2005	[HOX11L2 expression and its clinical significance in paraffin-embedded T-lymphoblastic lymphoma].	Paraffin	53-61	T cell leukemia homeobox 3	Homo sapiens	1-8
23994645-4	2013	This assay is successfully applied to the simultaneous detection of ERG3p, ERG5p, PTEN, and CEN10 genes in formalin-fixed, paraffin-embedded prostate tissues on BenchMark ULTRA instruments.	Paraffin	123-131	phosphatase and tensin homolog	Homo sapiens	82-86
16532965-1	2005	OBJECTIVE: To determine the feasibility of detecting target gene expression and evaluate the expression of homeobox gene HOX11L2 as well as its clinical significance in paraffin-embedded T-lymphoblastic lymphoma T-LBL.	Paraffin	169-177	T cell leukemia homeobox 3	Homo sapiens	121-128
16532965-2	2005	METHODS: HOX11L2 mRNA was analyzed by RT-PCR and real-time fluorescent quantitative PCR (RQ-PCR) on paraffin-embedded tissues in 54 cases of T-LBL.	Paraffin	100-108	T cell leukemia homeobox 3	Homo sapiens	9-16
23999248-5	2013	Immunohistochemical assessment of paraffin-embedded tissues from 44 RMS showed beta-catenin expression in 26 cases with cytoplasmic/membranous expression in 9/14 cases of alveolar RMS, and 15/30 cases of embryonal RMS, whereas nuclear expression was only seen in 2 cases of embryonal RMS.	Paraffin	34-42	catenin beta 1	Homo sapiens	79-91
16086967-4	2005	METHODS: CXCL13 expression in paraffin-embedded adnexal biopsy specimens was determined by indirect immunohistochemistry with antigen retrieval.	Paraffin	30-38	C-X-C motif chemokine ligand 13	Homo sapiens	9-15
23737133-6	2013	The expression of VPS4B was evaluated by Western blot in 8 paired fresh NSCLC tissues and immunohistochemistry on 105 paraffin-embedded slices.	Paraffin	118-126	vacuolar protein sorting 4 homolog B	Homo sapiens	18-23
16049314-5	2005	In addition, Pyrosequencing proved superior to dideoxy sequencing in the detection of KRAS mutations from DNA mixtures of paraffin-embedded colon cancer and normal tissue as well as from paraffin-embedded pancreatic cancers.	Paraffin	122-130	KRAS proto-oncogene, GTPase	Homo sapiens	86-90
23410206-5	2013	METHODS: We examined immunohistochemical expression of the Hh signaling mediators Sonic Hedgehog (Shh) and Glioblastoma (Gli)2 in paraffin-embedded normal versus histologically characterized human MTC tissue.	Paraffin	130-138	sonic hedgehog signaling molecule	Homo sapiens	82-96
16038038-5	2005	In situ hybridization was done to examine the messenger RNA expression of ICAM-1 in formalin-fixed, paraffin-embedded sections using peptide nucleic acid probes and the catalyzed signal amplification (CSA) technique.	Paraffin	100-108	intercellular adhesion molecule 1	Homo sapiens	74-80
23410206-5	2013	METHODS: We examined immunohistochemical expression of the Hh signaling mediators Sonic Hedgehog (Shh) and Glioblastoma (Gli)2 in paraffin-embedded normal versus histologically characterized human MTC tissue.	Paraffin	130-138	sonic hedgehog signaling molecule	Homo sapiens	98-101
15958307-2	2005	METHODS: SP immunohistochemistry was used to detect the expressions of CK19 and TPO in paraffin-embedded thyroid tissue specimens obtained from 62 patients with thyroid carcinoma (30 with papillary carcinomas, 22 with follicular variant of papillary carcinomas, and 10 with follicular carcinomas) and 44 with benign thyroid diseases (including 22 with multinodular goiters, 14 with adenoma, and 8 with Hashimoto thyroiditis).	Paraffin	87-95	thyroid peroxidase	Homo sapiens	80-83
24019826-5	2013	Due to limited number of studies on DNMT3B promoter methylation, this study was performed to quantitatively measure the methylation level of DNMT3B gene in archival formalin fixed paraffin embedded (FFPE) tissues from breast cancer patients.	Paraffin	180-188	DNA methyltransferase 3 beta	Homo sapiens	141-147
15915369-7	2005	The expression of MGMT protein in paraffin-embedded tissue was examined by immunohistochemistry.	Paraffin	34-42	O-6-methylguanine-DNA methyltransferase	Homo sapiens	18-22
15722793-4	2005	In this study, the immunohistochemical expression of the deleted in colorectal cancer gene (DCC) and p27Kip1 was assessed in 168 paraffin-embedded, formalin-fixed tumors of patients with stage II and III colorectal cancer.	Paraffin	129-137	DCC netrin 1 receptor	Homo sapiens	92-95
16045581-3	2005	We studied Glut1 expression by immunohistochemistry of paraffin sections from 63 esophageal squamous cell carcinomas.	Paraffin	55-63	solute carrier family 2 member 1	Homo sapiens	11-16
23611620-0	2013	Source and migration of short-chain chlorinated paraffins in the coastal East China Sea using multiproxies of marine organic geochemistry.	Paraffin	48-57	S13 erythroblastosis (avian) oncogene homolog	Homo sapiens	84-87
15783050-3	2005	Immunohistochemical staining of the paraffin sections was performed using polyclonal antibody to KAI1.	Paraffin	36-44	CD82 molecule	Homo sapiens	97-101
16244703-4	2005	MATERIALS AND METHODS: We investigated the immunohistochemical expression of CD30 antigen in paraffin-embedded tissue samples representing all systems from 30 fetuses after therapeutic abortion at 8th to 10th and 12th to 16th week of gestation, respectively, using the monoclonal antibody Ber-H2.	Paraffin	93-101	TNF receptor superfamily member 8	Homo sapiens	77-81
23559304-3	2013	DMP-1 expression was immunohistochemically determined in paraffin sections of a wide range of benign and malignant primary bone tumours and tumour-like lesions (n = 353).	Paraffin	57-65	dentin matrix acidic phosphoprotein 1	Homo sapiens	0-5
15470676-7	2004	We compared the expression of two neuronal markers, neuron-specific beta-tubulin (BT) and protein gene product 9.5, and olfactory marker protein (OMP), a marker of mature olfactory sensory neurons, in paraffin-embedded VNO sections from two strepsirrhine and four haplorhine species, all of which retain morphologically well-defined VNOs during postnatal life.	Paraffin	201-209	olfactory marker protein	Homo sapiens	120-144
15565546-0	2004	Identification of various exon combinations of the ews/fli1 translocation: an optimized RT-PCR method for paraffin embedded tissue -- a report by the CWS-study group.	Paraffin	106-114	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	55-59
24056643-4	2013	AIM: The purpose was to report chromosome 7 aberrations in ccRCC and pRCC using SISH in paraffin-embedded tissues and determine the association between the anomalies with clinical and pathological features.	Paraffin	88-96	proline rich mitotic checkpoint control factor	Homo sapiens	69-73
15592587-1	2004	The distribution of androgen receptor (AR) and cytochrome P450 aromatase was investigated in paraffin sections of pregnant pig ovary.	Paraffin	93-101	androgen receptor	Sus scrofa	20-37
23458716-3	2013	METHODS: Immunohistochemical staining using monoclonal antibody FU-MK-1 against MK-1 antigen was performed on paraffin-embedded tissues from 64 gastric carcinoma patients with liver metastasis.	Paraffin	110-118	potassium voltage-gated channel subfamily A member 1	Homo sapiens	80-84
15376255-6	2004	There were cells with low levels of CK8/18 expression in frozen sections that may correspond to the CK8/18 "negative" cells seen in paraffin wax sections.	Paraffin	132-144	keratin 8	Homo sapiens	36-39
15376255-6	2004	There were cells with low levels of CK8/18 expression in frozen sections that may correspond to the CK8/18 "negative" cells seen in paraffin wax sections.	Paraffin	132-144	keratin 8	Homo sapiens	100-103
23625595-5	2013	PTEN expression was evaluated using immunohistochemical staining on paraffin-embedded specimens and compared to clinicopathological features of tumors.	Paraffin	68-76	phosphatase and tensin homolog	Homo sapiens	0-4
15195108-3	2004	Using paraffin-embedded bone marrow biopsy sections, we found PAX5/BSAP was expressed in 72% (18/25) of cases overall with an intensity ranging from weak (10, 56%) to strong (8, 44%).	Paraffin	6-14	paired box 5	Homo sapiens	62-66
15195108-3	2004	Using paraffin-embedded bone marrow biopsy sections, we found PAX5/BSAP was expressed in 72% (18/25) of cases overall with an intensity ranging from weak (10, 56%) to strong (8, 44%).	Paraffin	6-14	paired box 5	Homo sapiens	67-71
23370430-10	2013	In summary, we report a novel COLD-PCR/FMCA method that provides rapid and sensitive detection of IDH1 mutations in formalin-fixed paraffin-embedded tissue and can be used in the clinical setting to assess the small brain biopsies.	Paraffin	131-139	isocitrate dehydrogenase (NADP(+)) 1	Homo sapiens	98-102
15236323-7	2004	However, counting of CL in serial paraffin sections revealed a significant higher number of CL in the NK1-R deficient mice in comparison to the wild-type group (P &lt; 0.01).	Paraffin	34-42	tachykinin receptor 1	Mus musculus	102-107
22939954-3	2013	The expression of galectin 1 was determined in 73 formalin-fixed, paraffin-embedded cervical cancer tissues using an immunohistochemical method and compared with clinicopathologic risk factors for recurrence after surgery.	Paraffin	66-74	galectin 1	Homo sapiens	18-28
15148649-3	2004	METHODS: The expression of DCC was evaluated immunohistochemically in 74 paraffin-embedded tumor samples from patients with Stage II (n = 41) and Stage III (n = 33) colorectal carcinomas.	Paraffin	73-81	DCC netrin 1 receptor	Homo sapiens	27-30
24020190-4	2013	Protocol of the reaction demonstrating PGP 9.5 on paraffin sections is presented.	Paraffin	50-58	ubiquitin C-terminal hydrolase L1	Homo sapiens	39-46
15194392-11	2004	The K-ras mutations were detected in the paraffin-embedded PA, but not in the prepared islets or in the peripheral blood.	Paraffin	41-49	KRAS proto-oncogene, GTPase	Homo sapiens	4-9
23344868-2	2013	MATERIAL AND METHODS: The ErbB2 and beta-catenin immunostaining was     performed on paraffin embedded tissue sections of 20 ACP using     avidin-biotin-peroxidase complex method.	Paraffin	85-93	catenin beta 1	Homo sapiens	36-48
22766794-12	2012	Detection of CTNNB1 mutations in formalin-fixed paraffin-embedded tissues among spindle cell lesions is proposed as a specific diagnostic tool for the diagnosis of desmoid tumors.	Paraffin	48-56	catenin beta 1	Homo sapiens	13-19
15074178-2	2004	Part of the incidence of breast cancer can be explained by BRCA1 and BRCA2 germline mutations, which with current techniques can be retrospectively analysed in stored, paraffin-embedded tissue samples.	Paraffin	168-176	BRCA1 DNA repair associated	Homo sapiens	59-64
15074178-2	2004	Part of the incidence of breast cancer can be explained by BRCA1 and BRCA2 germline mutations, which with current techniques can be retrospectively analysed in stored, paraffin-embedded tissue samples.	Paraffin	168-176	BRCA2 DNA repair associated	Homo sapiens	69-74
23073586-2	2012	METHODS: Immunohistochemistry assay was used to examine the expressions of HMGA2 and P53 in 50 paraffin-embedded tissue specimens of human serous ovarian cancer and 4 normal fallopian tube tissues.	Paraffin	95-103	high mobility group AT-hook 2	Homo sapiens	75-80
15133292-1	2004	The tumor suppressor gene Tp53 was analyzed by polymerase chain reaction-amplification of genomic DNA extracted from paraffin-embedded tissue sections of rat lung tumors to compare mutations that occurred after inhalation exposures to plutonium dioxide, neptunium dioxide, or radon and radon progenies.	Paraffin	117-125	tumor protein p53	Rattus norvegicus	26-30
22911383-4	2012	METHODS: Paraffin sections of pancreases from 187 brain-deceased donors (HbA(1c) &lt;6.5% [48 mmol/mol]) were used to genotype the TCF7L2 variant rs7903146 and evaluate its impact on islet morphology and alpha and beta cell subpopulations following immunostaining for glucagon and C-peptide.	Paraffin	9-17	transcription factor 7 like 2	Homo sapiens	131-137
21114636-4	2012	METHODS: Immunohistochemical analysis of HSP-27 protein expression was performed on formalin-fixed, paraffin-embedded sections from 99 UM of known chromosome 3 status, as determined by multiplex ligation-dependent probe amplification.	Paraffin	100-108	heat shock protein family B (small) member 1	Homo sapiens	41-47
22460808-3	2012	HERG1 protein expression was evaluated by immunohistochemistry in paraffin-embedded tissue specimens from 133 patients with laryngeal/hypopharyngeal squamous cell carcinomas and 75 patients with laryngeal dysplasia, and correlated with clinical data.	Paraffin	66-74	potassium voltage-gated channel subfamily H member 2	Homo sapiens	0-5
22851866-9	2012	CONCLUSION: We have established novel methods for quantitative PCR for hepcidin using RNAs isolated from paraffin-embedded sections and in situ hybridization of HCC.	Paraffin	105-113	hepcidin antimicrobial peptide	Homo sapiens	71-79
22738050-3	2012	PROCEDURES: CB1 and CB2 were immunohistochemically localized in formalin-fixed, paraffin-embedded sections of tissue samples.	Paraffin	80-88	cannabinoid receptor 1	Canis lupus familiaris	12-15
22710816-4	2012	Fluorescent in situ hybridization for MLL gene expression was performed on paraffin-embedded tissue.	Paraffin	75-83	lysine methyltransferase 2A	Homo sapiens	38-41
21999410-0	2012	Novel antibody capture assay for paraffin-embedded tissue detects wide-ranging amyloid beta and paired helical filament-tau accumulation in cognitively normal older adults.	Paraffin	33-41	microtubule associated protein tau	Homo sapiens	120-123
22402874-0	2012	Detection of genetic variation in KCNQ1 gene by high-resolution melting analysis in a prospective-based series of postmortem negative sudden death: comparison of results obtained in fresh frozen and formalin-fixed paraffin-embedded tissues.	Paraffin	214-222	potassium voltage-gated channel subfamily Q member 1	Homo sapiens	34-39
22738781-1	2012	The purpose of this study was to investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and correlate it with OPN expression and function in squamous carcinoma of tongue.Paraffin were sections of 80 samples with squamous carcinoma of tongue and 40 samples with normal tissue of tongue for benign lesion having undergone surgery.	Paraffin	213-221	CEA cell adhesion molecule 5	Homo sapiens	63-120
22738781-1	2012	The purpose of this study was to investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and correlate it with OPN expression and function in squamous carcinoma of tongue.Paraffin were sections of 80 samples with squamous carcinoma of tongue and 40 samples with normal tissue of tongue for benign lesion having undergone surgery.	Paraffin	213-221	CEA cell adhesion molecule 5	Homo sapiens	122-129
22738781-1	2012	The purpose of this study was to investigate the expression of carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5) and correlate it with OPN expression and function in squamous carcinoma of tongue.Paraffin were sections of 80 samples with squamous carcinoma of tongue and 40 samples with normal tissue of tongue for benign lesion having undergone surgery.	Paraffin	213-221	secreted phosphoprotein 1	Homo sapiens	153-156
21889920-5	2012	BAF250a expression was evaluated by immunohistochemistry in 112 paraffin-embedded surgical specimens of invasive breast cancers and 20 cases of matched normal breast tissues.	Paraffin	64-72	AT-rich interaction domain 1A	Homo sapiens	0-7
22137559-3	2012	MATERIALS AND METHODS: We investigated the expression pattern of ezrin immunohistochemically in 89 paraffin samples of NSCLC between January 1998 and December 2006 and conducted survival analyses.	Paraffin	99-107	ezrin	Homo sapiens	65-70
22137559-5	2012	RESULTS: In 89 paraffin samples, ezrin was expressed in 40 cases, either in the cytoplasm or on the membrane.	Paraffin	15-23	ezrin	Homo sapiens	33-38
22006578-0	2012	TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy.	Paraffin	41-49	thymidylate synthetase	Homo sapiens	0-2
22357131-7	2012	METHODS: In this study, we examined NAIP protein expression in 101 Formalin-Fixed Paraffin-Embedded blocks including samples from 39 Hodgkin Lymphoma and 23 Non Hodgkin Lymphoma cases in comparison with 39 control samples (30 normal and 9 Reactive Lymphoid Hyperplasia (RLH) lymph nodes) using semi-quantitative immuno-flourecent Staining.	Paraffin	82-90	NLR family apoptosis inhibitory protein	Homo sapiens	36-40
21598109-4	2012	Moreover, expressions of HMGA2 were performed by western blotting and further confirmed by 150 paired of formalin-fixed, paraffin-embeded (FFPE) ESCC and NAT by immunohistochemistry (IHC).	Paraffin	121-129	high mobility group AT-hook 2	Homo sapiens	25-30
23163110-5	2012	METHODS: We developed a protocol for non-radioactive in situ hybridization for the mRNA of the two endothelin receptors on paraffin-embedded tissue using digoxigenin-labeled RNA probes.	Paraffin	123-131	endothelin 1	Mus musculus	99-109
22031231-3	2012	ERCC1 expression was evaluated by immunohistochemistry (IHC) on the formalin-fixed paraffin-embedded diagnostic biopsies.	Paraffin	83-91	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	0-5
22230505-3	2012	Annexin  II expression was examined in 120 samples of paraffin-embedding ccRCC and the corresponding normal renal tissues using immunohistochemistry.	Paraffin	54-62	annexin A2	Homo sapiens	0-11
22005837-4	2011	The immunoprofile of Muc5b was determined on paraffin-embedded and frozen mouse tissue sections and showed a similar expression pattern in mouse to that in the human.	Paraffin	45-53	mucin 5, subtype B, tracheobronchial	Mus musculus	21-26
21981340-8	2011	Importantly, an approach to detect CD200 in paraffin sections was newly developed.	Paraffin	44-52	CD200 molecule	Homo sapiens	35-40
21958527-3	2011	TEM-7 expression was assessed by in situ hybridization or by immunohistochemistry (IHC) in 130 formalin-fixed paraffin-embedded (FFPE) and 410 frozen human clinical specimens of cancer plus 301 normal tissue samples.	Paraffin	110-118	plexin domain containing 1	Homo sapiens	0-5
21887466-3	2011	Expression of DNMT1, DNMT3A and DNMT3B in paraffin sections from 54 gastric cancer patients were examined using immunohistochemistry, and their associations with the corresponding clinicopathological parameters were analyzed using the Chi-square test.	Paraffin	42-50	DNA methyltransferase 3 beta	Homo sapiens	32-38
22018336-2	2011	METHODS: The expression of MK-1 and RegIV was detected by immunohistochemical method in paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp (n = 15), and chronic cholecystitis (n = 35).	Paraffin	88-96	potassium voltage-gated channel subfamily A member 1	Homo sapiens	27-31
22018336-2	2011	METHODS: The expression of MK-1 and RegIV was detected by immunohistochemical method in paraffin-embedded sections of surgical resected specimens from gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp (n = 15), and chronic cholecystitis (n = 35).	Paraffin	88-96	regenerating family member 4	Homo sapiens	36-41
21878536-4	2011	EXPERIMENTAL DESIGN: PTEN IHC was validated by employing formalin fixed and paraffin-embedded isogenic human cell lines containing or lacking intact PTEN alleles.	Paraffin	76-84	phosphatase and tensin homolog	Homo sapiens	21-25
21974818-3	2011	METHODS: This study investigated the GPER expression in paraffin-embedded samples from non neoplastic and neoplastic human testes (sex-cord stromal and germ cell tumors) by immunohistochemical and Western Blot analyses.	Paraffin	56-64	C-X-C motif chemokine receptor 6	Homo sapiens	37-41
21623385-7	2011	Immunohistochemical staining for p63 was performed on paraffin sections from 38 rhabdomyosarcomas, five leiomyomas, five leiomyosarcomas, five rhabdomyomas, five rhabdomyomatous Wilms tumors, three normal cardiac muscles, one medullomyoblastoma, one pleuropulmonary blastoma with rhabdomyomatous differentiation, and one teratoma with prominent rhabdomyoblasts.	Paraffin	54-62	tumor protein p63	Homo sapiens	33-36
21516130-5	2011	Immunohistochemical staining using paraffin-embedded tumor tissues revealed that the metastasis-free rate was significantly better in tumors negative for AFAP1L1 (P=0.0093 by log-rank test).	Paraffin	35-43	actin filament associated protein 1 like 1	Homo sapiens	154-161
21448785-6	2011	EMMPRIN expression in a series of 56 MB with various grades and pathological types was analyzed by immunohistochemical staining on paraffin-embedded sections.	Paraffin	131-139	basigin (Ok blood group)	Homo sapiens	0-7
21207061-4	2011	METHODS: Expression of OPN was examined using an immunohistochemical method in paraffin-embedded sections collected from 49 patients with lung cancer.	Paraffin	79-87	secreted phosphoprotein 1	Homo sapiens	23-26
21532495-0	2011	HMGA2 expression analysis in cytological and paraffin-embedded tissue specimens of thyroid tumors by relative quantitative RT-PCR.	Paraffin	45-53	high mobility group AT-hook 2	Homo sapiens	0-5
21383546-9	2011	An increased percentage of immunoreactive cells and a higher staining intensity in cancerous vs. non-cancerous paraffin sections paralleled higher mRNA levels of OATP2A1, OATP3A1, OATP4A1 and OATP5A1 in cancerous tissues of HCC, CCC and MLT patients.	Paraffin	111-119	solute carrier organic anion transporter family member 3A1	Homo sapiens	171-178
20846665-4	2011	The present study describes a polymerase chain reaction assay that allows for complete sequencing of clonally recombined T-cell receptor (TCR) gamma chain genes from formalin-fixed and paraffin wax-embedded samples of feline lymphoma.	Paraffin	185-197	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	121-136
20846665-4	2011	The present study describes a polymerase chain reaction assay that allows for complete sequencing of clonally recombined T-cell receptor (TCR) gamma chain genes from formalin-fixed and paraffin wax-embedded samples of feline lymphoma.	Paraffin	185-197	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	138-141
21171089-4	2011	Immunohistochemistry analysis revealed that 53.5% (38/71) paraffin-embedded archived glioma specimens exhibited high levels of IKBKE expression.	Paraffin	58-66	inhibitor of nuclear factor kappa B kinase subunit epsilon	Homo sapiens	127-132
22179016-2	2011	To investigate a possible involvement of the non-gastric H(+)/K(+) ATPase ATP12A (ATP1AL1) in prostate cancer, we performed immunohistochemistry in formalin-fixed, paraffin-embedded histological sections from benign and malignant human prostate lesions.	Paraffin	164-172	ATPase H+/K+ transporting non-gastric alpha2 subunit	Homo sapiens	82-89
21069438-3	2011	In the present study we developed a robust in situ hybridization assay using high-affinity Locked Nucleic Acid (LNA) probes that specifically detect miR-21 in formalin-fixed paraffin embedded (FFPE) tissue samples.	Paraffin	174-182	microRNA 21	Homo sapiens	149-155
22194833-4	2011	METHODOLOGY/PRINCIPAL FINDINGS: We measured the expression of mir-21 and mir-143 in 142 formalin-fixed, paraffin embedded (FFPE) cervical biopsy tissue blocks, collected from Dantec Oncology Clinic, Dakar, Senegal.	Paraffin	104-112	microRNA 21	Homo sapiens	62-68
21654158-4	2011	Restricted nuclear expression of Ap-2gamma to undifferentiated male germ cells was verified by coexpression of Ap-2gamma with promyelocytic leukemia zinc finger in sections of paraffin-embedded testes as well as in cells sorted positive for CD9 and CD90 expression.	Paraffin	176-184	transcription factor AP-2 gamma	Rattus norvegicus	33-42
21074689-1	2010	Human telomerase reverse transcriptase (hTERT) proteins in colorectal cancer investigated in several studies, but to our knowledge, hTERT expression has not been evaluated in all of colorectal tumors, including hyperplastic polyps (HPs), adenomas, and carcinomas, on paraffin-embedded tissue sections.	Paraffin	267-275	telomerase reverse transcriptase	Homo sapiens	6-38
21074689-1	2010	Human telomerase reverse transcriptase (hTERT) proteins in colorectal cancer investigated in several studies, but to our knowledge, hTERT expression has not been evaluated in all of colorectal tumors, including hyperplastic polyps (HPs), adenomas, and carcinomas, on paraffin-embedded tissue sections.	Paraffin	267-275	telomerase reverse transcriptase	Homo sapiens	40-45
20959655-1	2010	We studied the expression of CD200, an immunoglobulin superfamily membrane glycoprotein, in a wide range of B cell-derived neoplasms by immunohistochemical staining of paraffin-embedded tissue sections.	Paraffin	168-176	CD200 molecule	Homo sapiens	29-34
20564745-5	2010	PAI-1 expression was evaluated immunohistochemically in paraffin-embedded tissues (94 tumor samples and 10 adjacent normal tissue samples).	Paraffin	56-64	serpin family E member 1	Homo sapiens	0-5
20723930-3	2010	MATERIALS AND METHODS: We analyzed gene expression profiles from formalin fixed, paraffin embedded, localized prostate cancer tissues to identify genes associated with prostate specific antigen recurrence.	Paraffin	81-89	kallikrein related peptidase 3	Homo sapiens	168-193
20524960-7	2010	The use of protein aggregation filtration blots and paraffin-embedded tissue blots displayed depositions of alpha-syn aggregates within sciatic nerve axons of transgenic mice.	Paraffin	52-60	synuclein, alpha	Mus musculus	108-117
20593490-4	2010	Kv3.4 protein expression was evaluated by immunohistochemistry in paraffin-embedded tissue specimens from 84 patients with laryngeal/pharyngeal squamous cell carcinomas and 67 patients with laryngeal dysplasias.	Paraffin	66-74	potassium voltage-gated channel subfamily C member 4	Homo sapiens	0-5
20216404-0	2010	Protocol for PTEN expression by immunohistochemistry in formalin-fixed paraffin-embedded human breast carcinoma.	Paraffin	71-79	phosphatase and tensin homolog	Homo sapiens	13-17
20216404-4	2010	Here, we describe an automated and reliable protocol for PTEN protein expression by immunohistochemistry in formalin-fixed paraffin-embedded tissue that can be easily incorporated into clinical trials.	Paraffin	123-131	phosphatase and tensin homolog	Homo sapiens	57-61
20442643-4	2010	Here we report on a novel monoclonal antibody recognizing the c-myc protein in formalin-fixed, paraffin-embedded tissue which we used to evaluate a spectrum of aggressive B-cell lymphomas by standard immunohistochemistry.	Paraffin	95-103	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	62-67
20048674-9	2010	There was excellent correlation in the distribution pattern of the 2 markers, although hCDC47 was more sensitive.Thus this marker may have important clinical and research applications because of its activity in formalin-fixed, paraffin-embedded, proliferating, normal, and neoplastic tissue.	Paraffin	227-235	minichromosome maintenance complex component 7	Homo sapiens	87-93
20592339-4	2010	In this study, the expression pattern of galectin-1 was determined in 73 formalin-fixed, paraffin-embedded vulvar tissues by a standard immunohistochemical method: 12 benign vulvar specimen, 41 vulvar intraepithelial lesions (VIN), according to their differentiation were subdivided into VIN I, II and III and 20 invasive squamous cell carcinomas (ISCC).	Paraffin	89-97	galectin 1	Homo sapiens	41-51
20592344-4	2010	The antibody was also successfully applied to stain KEPI protein in paraffin sections of human brain.	Paraffin	68-76	protein phosphatase 1 regulatory inhibitor subunit 14C	Homo sapiens	52-56
20393008-4	2010	MATERIALS AND METHODS: SPARC mRNA expression was evaluated in 104 formalin-fixed paraffin-embedded tissue samples of pancreatic adenocarcinoma patients with macro-dissection technique.	Paraffin	81-89	secreted protein acidic and cysteine rich	Homo sapiens	23-28
20087351-4	2010	METHODS: Stathmin1 expression in paraffin-embedded tissue sections from 226 patients was analysed by immunohistochemistry.	Paraffin	33-41	stathmin 1	Homo sapiens	9-18
20051956-5	2010	Immunohistochemistry for FRalpha was carried out on 62 paraffin-embedded samples of mesothelioma from patients who were subsequently treated with pemetrexed.	Paraffin	55-63	FOS like 1, AP-1 transcription factor subunit	Homo sapiens	25-32
19929564-3	2010	MATERIAL AND METHODS: Immunohistochemistry for MMP-7 was performed in a series of 107 paraffin-embedded sections of SGC.	Paraffin	86-94	matrix metallopeptidase 7	Homo sapiens	47-52
20465611-3	2010	METHODS: We used immunohistochemical techniques to examine the expression of ezrin in paraffin-embedded tissues of squamous cell carcinoma (n = 23), basal cell carcinoma (n = 10), Bowen"s disease (n = 10), actinic keratosis (n = 10), keratoacanthoma (n = 9), seborrheic keratosis (n = 5), psoriasis vulgaris (n = 5), and normal control skin (n = 5).	Paraffin	86-94	ezrin	Homo sapiens	77-82
20025500-0	2009	A monoclonal antibody for detection of folylpolyglutamate synthetase in paraffin embedded tissues.	Paraffin	72-80	folylpolyglutamate synthase	Homo sapiens	39-68
20025500-4	2009	In spite of its key role in both nucleotide biosynthesis and possible role as a determinant of response in chemotherapy, monoclonal antibodies to FPGS suitable for immunohistochemical analysis of formalin fixed and paraffin embedded biopsy samples, or that can be used for Western blot analysis, are not commercially available.	Paraffin	215-223	folylpolyglutamate synthase	Homo sapiens	146-150
20025500-5	2009	The aim of this study was to generate a monoclonal antibody that could be used to detect specific expression of FPGS in paraffin embedded tissues.	Paraffin	120-128	folylpolyglutamate synthase	Homo sapiens	112-116
20025500-11	2009	Our results show that clone NN3.2 is a sensitive tool for detection of FPGS in paraffin-embedded tissues.	Paraffin	79-87	folylpolyglutamate synthase	Homo sapiens	71-75
20359085-2	2009	METHOD: Ninety-two cases of paraffin section with immunoperoxidase (SP) staining method was used to detect the distribution of Pin1 and CyclinD1 in 10 cases of laryngeal normal epithelial tissue, 39 cases of laryngeal papilloma, 27 cases of laryngeal papilloma with middle, severe atypical hyperplasia and 16 cases of laryngeal carcinoma.	Paraffin	28-36	peptidylprolyl cis/trans isomerase, NIMA-interacting 1	Homo sapiens	127-131
19521953-2	2009	In this study, we examined the expression of one such marker, the high-mobility group AT-hook 2 gene (HMGA2) mRNA, in 53 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas (MEC) and four normal parotid tissues using quantitative real-time RT-PCR (qPCR).	Paraffin	137-145	high mobility group AT-hook 2	Homo sapiens	66-95
19521953-2	2009	In this study, we examined the expression of one such marker, the high-mobility group AT-hook 2 gene (HMGA2) mRNA, in 53 formalin-fixed, paraffin-embedded mucoepidermoid carcinomas (MEC) and four normal parotid tissues using quantitative real-time RT-PCR (qPCR).	Paraffin	137-145	high mobility group AT-hook 2	Homo sapiens	102-107
19230971-8	2009	We then examined CD200 expression on paraffin-embedded lymphoid tissues and bone marrow (BM) trephine biopsies from 23 B-CLL and 44 MCL patients.	Paraffin	37-45	CD200 molecule	Homo sapiens	17-22
19694703-3	2009	METHODS: The expression of osteopontin was immunohistochemically analysed from 68 normal cervix, 55 CIS and 52 invasive cervical cancer tissues using a paraffin-embedded tissue array.	Paraffin	152-160	secreted phosphoprotein 1	Homo sapiens	27-38
25610078-2	2009	Paraffin sections known to contain ubiquitinprotein conjugate immunureactivity in neurofibrillary tangles (NFT), cortical Lewy bodies, Rosenthal fibres and in Pick bodies were immunostained with PGP9.5.	Paraffin	0-8	protein interacting with PRKCA 1	Homo sapiens	159-163
19864241-3	2009	Immunohistochemical staining using monoclonal antibody FU-MK-1 (MK-1 antigen) was performed on paraffin-embedded tissues from 63 patients who had undergone surgical resection for gallbladder carcinoma.	Paraffin	95-103	potassium voltage-gated channel subfamily A member 1	Homo sapiens	58-62
19864241-3	2009	Immunohistochemical staining using monoclonal antibody FU-MK-1 (MK-1 antigen) was performed on paraffin-embedded tissues from 63 patients who had undergone surgical resection for gallbladder carcinoma.	Paraffin	95-103	potassium voltage-gated channel subfamily A member 1	Homo sapiens	64-68
19604345-3	2009	The aim of this study was to analyze the expression of NOD1 and NOD2 proteins in healthy mouse and dog eyes using immunohistochemistry on formalin-fixed, paraffin-embedded globes.	Paraffin	154-162	nucleotide-binding oligomerization domain containing 1	Mus musculus	55-59
19399936-8	2009	The immunohistochemistry was used to detect the ezrin expression in paraffin-embedded normal colorectal mucosa tissues and colorectal cancer tissue samples.	Paraffin	68-76	ezrin	Homo sapiens	48-53
15074058-4	2004	METHOD: CDX2 was investigated through immunohistochemistry on paraffin-embedded tissue, using the labelled streptavidin-biotin method (LSAB2, Dako) with a monoclonal antibody (CDX2-88, BioGenex).	Paraffin	62-70	caudal type homeobox 2	Homo sapiens	8-12
15000849-6	2004	A total of 16 antibodies were characterized for their reactivity with the nephrin by using ELISA, Western blots, immunoprecipitation and immunostaining of frozen and formaldehyde-fixed paraffin embedded tissue sections.	Paraffin	185-193	NPHS1 adhesion molecule, nephrin	Homo sapiens	74-81
14749636-5	2004	In addition, to validate gene expression data at the protein level, TADG-14 expression was evaluated by immunohistochemistry on paraffin-embedded tissue from which all 11 primary tumor cell lines were established.	Paraffin	128-136	kallikrein related peptidase 8	Homo sapiens	68-75
14749636-9	2004	Immunohistochemistry staining of paraffin-embedded cervical cancer specimens confirmed TADG-14 expression in tumor cells and its absence on normal cervical epithelial cells.	Paraffin	33-41	kallikrein related peptidase 8	Homo sapiens	87-94
15285310-2	2004	This study was undertaken to screen for the existence of K-ras gene point mutations in paraffin-embedded slides randomly selected from benign and malignant ovarian tumors applying the PCR-RFLP technique.	Paraffin	87-95	KRAS proto-oncogene, GTPase	Homo sapiens	57-62
14569466-3	2004	METHOD: Immunohistochemical analysis of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expression was carried out in paraffin-embedded sections of surgically resected esophageal squamous cell carcinoma (ESCC) (58 cases) and paired distal normal esophageal tissues (44 cases) and correlated with clinicopathological parameters.	Paraffin	144-152	matrix metallopeptidase 9	Homo sapiens	79-105
14569466-3	2004	METHOD: Immunohistochemical analysis of matrix metalloproteinase-2 (MMP-2) and matrix metalloproteinase-9 (MMP-9) expression was carried out in paraffin-embedded sections of surgically resected esophageal squamous cell carcinoma (ESCC) (58 cases) and paired distal normal esophageal tissues (44 cases) and correlated with clinicopathological parameters.	Paraffin	144-152	matrix metallopeptidase 9	Homo sapiens	107-112
15050102-4	2004	For the purpose of the study, c-Fos-IR has been analysed by immunohistochemical methods in rat pancreatic beta cells, pulpal undifferentiated ectomesenchimal cells (PUECs) that are known to have a neural crest origin, and in small intestine fibroblasts which do not have a neural crest origin, in formaline-fixed, paraffin-embedded sections.	Paraffin	314-322	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-35
14769134-3	2004	Paraffin sections were stained by using a primary monoclonal antibody against PTB.	Paraffin	0-8	polypyrimidine tract binding protein 1	Homo sapiens	78-81
14654791-3	2003	In this study, expression of BCL-6 was investigated by immunohistochemistry on paraffin-embedded specimens from 150 breast cancer patients and 10 specimens of normal breast tissue.	Paraffin	79-87	BCL6 transcription repressor	Homo sapiens	29-34
14555389-0	2003	Common ALK gene rearrangement in Asian CD30+ anaplastic large cell lymphoma: an immunohistochemical and fluorescence in situ hybridisation (FISH) study on paraffin-embedded tissue.	Paraffin	155-163	ALK receptor tyrosine kinase	Homo sapiens	7-10
2474040-13	1989	1C5 reacted with ethanol-fixed, and routine formalin-fixed and paraffin-embedded tissue.	Paraffin	63-71	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	0-3
2712596-3	1989	Detection of CA 125 was most intense in cryostat sections and decreased in formalin fixed and paraffin embedded tissues according to the duration of fixation.	Paraffin	94-102	mucin 16, cell surface associated	Homo sapiens	13-19
3052807-2	1988	1C5 can be used for the staining of routine formalin-fixed and paraffin-embedded tissue sections.	Paraffin	63-71	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta	Homo sapiens	0-3
2461901-6	1988	It was shown that DA7 and DC10 antibodies exhibited strong reaction in paraffin embedded tissues fixed in either methacarn or standard formalin.	Paraffin	71-79	myosin heavy chain 8	Homo sapiens	18-21
2461901-6	1988	It was shown that DA7 and DC10 antibodies exhibited strong reaction in paraffin embedded tissues fixed in either methacarn or standard formalin.	Paraffin	71-79	F-box protein 8	Homo sapiens	26-30
3067371-0	1988	[Identification of the ABO system in paraffin slices using the immunofluorescence technic].	Paraffin	37-45	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	23-26
3677781-5	1987	When we reacted 5 micron paraffin embedded sections of chorio-retinal complex fixed in 2% glutaraldehyde-1% paraformaldehyde, we observed increased PAS positivity, and staining with Weigert"s elastin and alcian blue at pH 2.5 in Bruch"s membranes from donors over 46 years.	Paraffin	25-33	elastin	Homo sapiens	192-199
3623553-2	1987	The expression of PLAP was examined with a polyclonal antibody and the immunoperoxidase technique in formalin-fixed, paraffin-embedded sections of 37 germ cell neoplasms and 483 somatic tumors.	Paraffin	117-125	alkaline phosphatase, germ cell	Homo sapiens	18-22
12960692-0	2003	Multiplex RT-PCR for the detection of common BCR-ABL fusion transcripts in paraffin-embedded tissues from patients with chronic myeloid leukemia and acute lymphoblastic leukemia.	Paraffin	75-83	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	45-52
12930690-1	2003	OBJECTIVE: To detect the PAX3-FKHR and PAX7-FKHR fusion transcripts in formalin-fixed, paraffin-embedded rhabdomyosarcoma tissues by one-step RT-PCR and discuss its diagnostic potential.	Paraffin	87-95	paired box 7	Homo sapiens	39-43
19521280-5	2009	Paraffin immunohistochemistry showed finely granular cytoplasmic ALK1 expression, positive CD138, IgA, p63 (VS38), focal positive epithelial membrane antigen and CD4, and lambda light chain restriction whereas negative CD20 and CD30 staining.	Paraffin	0-8	activin A receptor like type 1	Homo sapiens	65-69
12820316-7	2003	TPO was assessed immunohistochemically in paraffin-embedded specimens.	Paraffin	42-50	thyroid peroxidase	Homo sapiens	0-3
3480871-6	1987	Using a commercial kit on routinely fixed, paraffin embedded material, CA 125 positivity was demonstrated in 29 of 36 (80%) serous cystadenocarcinomas after pronase pre-treatment of the sections, in contrast to 100% (n = 25) positivity on frozen tissue sections.	Paraffin	43-51	mucin 16, cell surface associated	Homo sapiens	71-77
3480871-7	1987	CA 125 can, therefore, be demonstrated in routinely fixed paraffin embedded material, although the number of positive results is less than in fresh frozen sections.	Paraffin	58-66	mucin 16, cell surface associated	Homo sapiens	0-6
19521280-5	2009	Paraffin immunohistochemistry showed finely granular cytoplasmic ALK1 expression, positive CD138, IgA, p63 (VS38), focal positive epithelial membrane antigen and CD4, and lambda light chain restriction whereas negative CD20 and CD30 staining.	Paraffin	0-8	tumor protein p63	Homo sapiens	103-106
12641788-1	2003	BACKGROUND: Antibodies to CD4, CD8, TIA-1, and CD56 are available which perform well in formalin-fixed and paraffin-embedded tissue.	Paraffin	107-115	CD8a molecule	Homo sapiens	31-34
19054153-3	2009	METHODS: Immunohistochemistry for mutL homolog 1 (MLH1), mutS homolog 2 (MSH2), mutS homolog 6 (MSH6) and post-meiotic segregation increased 2 (PMS2) was carried out on formalin-fixed and paraffin-embedded sections of tumor and background liver.	Paraffin	188-196	mutS homolog 6	Homo sapiens	96-100
12538472-3	2003	EXPERIMENTAL DESIGN: p125(FAK) expression in formalin-fixed paraffin-embedded (FFPE) tissue was studied using immunohistochemical assays on 24 matched primary colorectal carcinomas and colorectal liver metastases as well as 18 different colorectal liver metastases using monoclonal anti-FAK 4.47.	Paraffin	60-68	SEC23 interacting protein	Homo sapiens	21-25
3621371-4	1987	Cytosolic epoxide hydrolase activity was induced by chlorinated paraffins, di(2-ethylhexyl)phthalate and clofibrate and depressed by alpha-naphthylisothiocyanate, 3-methylcholanthrene, benzil and quercitin.	Paraffin	64-73	epoxide hydrolase 2, cytoplasmic	Mus musculus	0-27
19212669-8	2009	We confirmed that GPC3 expression is specific to HCC component (8/11, 72.7%) but few samples also showed weakly in ICC component (2/11, 18.2%) of CHC sections among 11 cases compared with HCC biomarkers including AFP and hepatocyto paraffin 1 (HepPar1), and ICC biomarkers cytokeratin (CK) 7 and CK19.	Paraffin	232-240	glypican 3	Homo sapiens	18-22
3518399-0	1986	Immunohistochemical localization of CA 125 antigen in formalin-fixed paraffin sections of ovarian tumors with the use of Pronase.	Paraffin	69-77	mucin 16, cell surface associated	Homo sapiens	36-42
3518399-2	1986	Pretreatment of the paraffin sections with Pronase allowed subsequent detection of CA 125 antigen.	Paraffin	20-28	mucin 16, cell surface associated	Homo sapiens	83-89
3518399-5	1986	Overall, CA 125 antigen detectability rate in paraffin sections was found to be compatible with those reported in frozen sections.	Paraffin	46-54	mucin 16, cell surface associated	Homo sapiens	9-15
14584660-6	2003	Paraffin-embedded tissue blocks were treated with MMP-9 immunohistochemical stain.	Paraffin	0-8	matrix metallopeptidase 9	Homo sapiens	50-55
12456216-8	2002	Paraffin immunohistochemical studies showed positivity of the tumor cells for CD45, TIA-1, granzyme B, CD56, and CD3 epsilon.	Paraffin	0-8	protein tyrosine phosphatase receptor type C	Homo sapiens	78-82
12368208-4	2002	To explore this possibility, we generated a digoxigenin-labeled riboprobe to pol mu mRNA and used the probe and in situ hybridization to examine the expression pattern of the pol mu gene in formalin-fixed, paraffin-embedded tissue sections of 37 B-NHLs.	Paraffin	206-214	DNA polymerase mu	Homo sapiens	175-181
19378023-11	2009	We will describe our current techniques to detect TLR4 in paraffin-embedded human large intestine sections.	Paraffin	58-66	toll like receptor 4	Homo sapiens	50-54
3156803-1	1985	Immunohistochemical localization of human leukocyte common antigen (LCA), a major membrane glycoprotein restricted to leukocytes, was evaluated in paraffin sections of a wide variety of hematopoietic and nonhematopoietic tissues (294 specimens) with monoclonal antibodies (PD7/26 and 2B11).	Paraffin	147-155	protein tyrosine phosphatase receptor type C	Homo sapiens	42-72
3156803-12	1985	Human LCA represents an excellent cell marker for paraffin sections, to distinguish hematopoietic neoplasms, particularly of the lymphoid type, from poorly differentiated tumors of epithelial, mesenchymal, or neural derivation.	Paraffin	50-58	protein tyrosine phosphatase receptor type C	Homo sapiens	6-9
6365305-3	1984	Therefore, the melanoma-associated monoclonal antibody NKI/C-3, effective on paraffin sections, was tested with an indirect immunoperoxidase technique.	Paraffin	77-85	complement C3	Homo sapiens	59-62
6395880-1	1984	The Ca 1 antibody has been tested with an immunoperoxidase technique in sections of uterine cervix embedded in paraffin wax.	Paraffin	111-123	carbonic anhydrase 1	Homo sapiens	4-8
6406590-0	1983	Immunolabeling of carbonic anhydrase isoenzyme C and glial fibrillary acidic protein in paraffin-embedded tissue sections of human brain and retina.	Paraffin	88-96	carbonic anhydrase 2	Homo sapiens	18-48
6188883-1	1983	Bronchial endocrine cells containing gastrin-releasing peptide (GRP), a mammalian analog of bombesin, and adrenocorticotropic hormone (ACTH) were immunohistochemically localized in paraffin sections of normal and pathologic human lungs.	Paraffin	181-189	gastrin releasing peptide	Homo sapiens	37-62
6188883-1	1983	Bronchial endocrine cells containing gastrin-releasing peptide (GRP), a mammalian analog of bombesin, and adrenocorticotropic hormone (ACTH) were immunohistochemically localized in paraffin sections of normal and pathologic human lungs.	Paraffin	181-189	gastrin releasing peptide	Homo sapiens	64-67
6178285-3	1982	B2m was assessed by three methods: PAP technic on formalin-fixed, paraffin-embedded tissue; indirect immunofluorescence on frozen sections; and radioimmunoassay on soluble tumor extracts.	Paraffin	66-74	major histocompatibility complex, class I, G	Homo sapiens	0-3
7032307-0	1981	Detection of terminal transferase in paraffin sections with the immunoperoxidase technique.	Paraffin	37-45	DNA nucleotidylexotransferase	Homo sapiens	13-33
6175605-1	1981	The immunological specificity of the Amsterdam rabbit antiserum against human prostatic acid phosphatase was studied on paraffin sections of 200 prostatic carcinomas and 330 control tissues using an indirect peroxidase technique.	Paraffin	120-128	acid phosphatase 3	Homo sapiens	78-104
6164245-1	1981	The immunoperoxidase technique was used to study the occurrence of placenta-associated plasma protein A (PAPP-A, SP4) in formalin-fixed paraffin-embedded tissue specimens from 15 hydatidiform moles, 6 invasive moles and 7 choriocarcinomas.	Paraffin	136-144	Sp4 transcription factor	Homo sapiens	113-116
33790905-5	2021	By immunofluroescence and immunohistochemical imaging we observed that both nanobodies detected TNC expression in PFA and paraffin embedded human tissue from ulcerative colitis, solid tumors and liver metastasis.	Paraffin	122-130	tenascin C	Homo sapiens	96-99
33455577-5	2021	Immunohistochemical expression of AQP4 was analyzed using formalin-fixed paraffin-embedded brain tissue sections.	Paraffin	73-81	aquaporin 4	Canis lupus familiaris	34-38
33469349-8	2021	However, TdT presented with significant loss of antigen immunoreactivity in the paraffin-embedded tissues older than 3 years, giving rise to weak or moderate staining in a subset of cases.	Paraffin	80-88	DNA nucleotidylexotransferase	Homo sapiens	9-12
33163276-4	2020	We applied single and double immunohistochemistry to analyze spatial relationships between CD8+, FoxP3+ and CD20+ tumor-infiltrating lymphocytes (TILs) and the cells expressing Zeb1 in formalin-fixed, paraffin-embedded surgical specimens of 113 TNBCs.	Paraffin	201-209	zinc finger E-box binding homeobox 1	Homo sapiens	177-181
32863919-6	2020	The association between p62 expression level and patient prognosis was subsequently analyzed in 54 paraffin-embedded tumor specimens by immunohistochemistry assay.	Paraffin	99-107	nucleoporin 62	Homo sapiens	24-27
33072501-4	2020	Methods: Expression profiles of DNMT1 were investigated in fresh frozen tissues, patient-derived cells, and formalin-fixed paraffin-embedded tissues using immunoblotting and immunohistochemistry analysis.	Paraffin	123-131	DNA methyltransferase 1	Homo sapiens	32-37
32314796-9	2020	CXCR4 and MMP-2 proteins in tumor tissues were detected by immunohistochemistry on paraffin-embedded tissue sections.	Paraffin	83-91	C-X-C motif chemokine receptor 4	Homo sapiens	0-5
32543087-0	2020	Clinical evaluation of the effectiveness of fusion-induced asymmetric transcription assay-based reverse transcription droplet digital PCR for ALK detection in formalin-fixed paraffin-embedded samples from lung cancer.	Paraffin	174-182	ALK receptor tyrosine kinase	Homo sapiens	142-145
31771972-3	2020	The aim of this study was to compare the immunohistochemical expression of PRDX3 in formalin-fixed, paraffin-embedded (FFPE) primary UM tissues of patients who did and did not develop metastatic disease.	Paraffin	100-108	peroxiredoxin 3	Homo sapiens	75-80
32079384-5	2020	KRAS mutations were detected with the help of real-time Polymerase Chain Reaction technique through genomic DNA extracted from paraffin-embedded tumor tissue blocks.	Paraffin	127-135	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
31395960-1	2019	Authors have only now noticed that in the Figure 3a, the immunohistochemical analysis of IL-4Ralpha on paraffin-embedded sections from breast is incorrect: IL-4 from breast was duplicated and used for the IL-4Ralpha staining.	Paraffin	103-111	interleukin 4 receptor	Homo sapiens	89-99
31730527-5	2019	Methods AnxA1 expression was evaluated by an immunohistochemistry technique in "paraffin-embedded" renal tissue sections from autopsied fetuses at different gestational ages, in mature kidneys and renal cancer tissues.	Paraffin	80-88	annexin A1	Homo sapiens	8-13
31265735-8	2019	In addition, the paraffin sections analysis results revealed that the diameter and cross-sectional area of pectoralis muscle fiber significantly increased with age (P &lt; 0.05), and a significant positive correlation was shown between the MSTN gene expression level and muscle fiber diameter (P &lt; 0.05).	Paraffin	17-25	growth/differentiation factor 8	Columba livia	240-244
31190601-3	2019	METHODS: JAM-A expression levels in 44 epithelial ovarian cancer and 12 benign formalin-fixed paraffin-embedded samples were determined by reverse transcription quantitative polymerase chain reaction.	Paraffin	94-102	F11 receptor	Homo sapiens	9-14
31308404-5	2019	SDHC promoter methylation analysis of 32 paraffin embedded tumours (including 15 GIST and 17 PPGL) was performed using a pyrosequencing technique and correlated with SDHC gene expression.	Paraffin	41-49	succinate dehydrogenase complex subunit C	Homo sapiens	0-4
31050216-2	2019	In particular, robust IHC assays performed on formalin-fixed, paraffin-embedded (FFPE) tumor tissue are widely used as surrogate markers for ALK and ROS1 rearrangements and for detecting programmed death ligand 1 (PD-L1) expression in patients with advanced NSCLC; in addition, they have become essential for treatment decisions.	Paraffin	62-70	ALK receptor tyrosine kinase	Homo sapiens	141-144
31050216-2	2019	In particular, robust IHC assays performed on formalin-fixed, paraffin-embedded (FFPE) tumor tissue are widely used as surrogate markers for ALK and ROS1 rearrangements and for detecting programmed death ligand 1 (PD-L1) expression in patients with advanced NSCLC; in addition, they have become essential for treatment decisions.	Paraffin	62-70	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	149-153
30443013-3	2019	We evaluated K17 expression by immunohistochemistry in formalin-fixed, paraffin embedded tissue specimens of non-papillary invasive urothelial carcinoma (UC) (classical histological cases), high grade papillary UC (PUC-LG), low grade papillary UC (PUC-HG), papillary urothelial neoplasia of low malignant potential (PUNLMP), and normal bladder mucosa.	Paraffin	71-79	keratin 17	Homo sapiens	13-16
30765126-5	2019	Glomerular expression of PLA2R was analyzed in stored, formalin-fixed, paraffin-embedded kidney biopsy sections.	Paraffin	71-79	phospholipase A2 receptor 1	Homo sapiens	25-30
30995723-8	2019	Analysis of paraffin sections stained with EVG demonstrated increased elastin content in BAV patients.	Paraffin	12-20	elastin	Homo sapiens	70-77
30917791-5	2019	KRAS mutation test was performed on paraffin-embedded tumor samples using PCR methods.	Paraffin	36-44	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
31556562-5	2019	BRCA1/2 Next Generation Sequencing (NGS)-based analysis of formalin-fixed paraffin-embedded (FFPE) ovarian cancer samples becomes the standard of care.	Paraffin	74-82	BRCA1 DNA repair associated	Homo sapiens	0-7
29936257-8	2018	We conclude that BRCA1/2 formalin-fixed, paraffin-embedded tumor tissue analysis reliably detects BRCA1/2 variants.	Paraffin	41-49	BRCA1 DNA repair associated	Homo sapiens	17-24
29936257-8	2018	We conclude that BRCA1/2 formalin-fixed, paraffin-embedded tumor tissue analysis reliably detects BRCA1/2 variants.	Paraffin	41-49	BRCA1 DNA repair associated	Homo sapiens	98-105
30174892-8	2018	Expression of PD-L1 and PD-L2 on cytoplasm in paraffin embedded tumor samples were analyzed by immunohistochemistry staining and scored with a semi-quantitative method.	Paraffin	46-54	programmed cell death 1 ligand 2	Homo sapiens	24-29
29716546-6	2018	METHODS: In this study, we developed an immunohistochemical staining technique, using E-selectin-human Ig Fc chimera (E-Ig) to characterize the expression and localization of E-selectin binding sites on paraffin-embedded sections of different cancer tissue.	Paraffin	203-211	epilepsy, idiopathic generalized, susceptibility to 1	Homo sapiens	86-122
29453630-12	2018	Formalin-fixed paraffin-embedded cancer tissue can undergo testing within a routine molecular-diagnostic setting as a clinical BRCA1/2 mutation screening strategy.	Paraffin	15-23	BRCA1 DNA repair associated	Homo sapiens	127-134
29333926-6	2018	EN1 expression was analyzed in 199 TNBC paraffin-embedded tissue samples by immunohistochemistry.	Paraffin	40-48	engrailed homeobox 1	Homo sapiens	0-3
29475036-4	2018	METHODS: ADAMTS-6 expression was detected by immunohistochemistry (IHC) in 171 paraffin-embedded ESCC specimens; relationships with patients" clinicopathological features and Twist-1 expression were analyzed by the Pearson Chi-square method, respectively.	Paraffin	79-87	ADAM metallopeptidase with thrombospondin type 1 motif 6	Homo sapiens	9-17
29329643-4	2018	Immunostaining of galactose-deficient IgA1 with KM55 was performed in paraffin-embedded sections of renal biopsy specimens from 48 patients with IgAN and 49 patients with other renal diseases such as lupus nephritis, HCV-related nephropathy, IgA vasculitis with nephritis (IgA-VN), and membranous nephropathy.	Paraffin	70-78	immunoglobulin heavy constant alpha 1	Homo sapiens	38-42
12221329-5	2002	RESULTS: The sensitivity of K-ras mutational analysis was 83.3% (25/30) in paraffin-embedded samples and 72.7% (16/22) in surgically resected specimens of the malignancy.	Paraffin	75-83	KRAS proto-oncogene, GTPase	Homo sapiens	28-33
12170084-1	2002	Hepatocyte monoclonal antibody (Hep) (alternatively Hep Par 1 for Hep paraffin 1) has been reported to stain normal hepatic tissue and hepatocellular carcinoma (HCC) with high specificity.	Paraffin	70-78	DNL-type zinc finger	Homo sapiens	0-3
12170084-1	2002	Hepatocyte monoclonal antibody (Hep) (alternatively Hep Par 1 for Hep paraffin 1) has been reported to stain normal hepatic tissue and hepatocellular carcinoma (HCC) with high specificity.	Paraffin	70-78	DNL-type zinc finger	Homo sapiens	32-35
12170084-1	2002	Hepatocyte monoclonal antibody (Hep) (alternatively Hep Par 1 for Hep paraffin 1) has been reported to stain normal hepatic tissue and hepatocellular carcinoma (HCC) with high specificity.	Paraffin	70-78	DNL-type zinc finger	Homo sapiens	32-35
12171495-2	2002	DESIGN: We performed immunohistochemistry for detection of CD10 and Bcl-6 in paraffin-embedded tissue sections from 32 patients who had surgically resected primary intestinal lymphomas.	Paraffin	77-85	BCL6 transcription repressor	Homo sapiens	68-73
12437120-4	2002	The immunohistochemistry method was adopted for the detection of cathepsin B using paraffin embedded specimens.	Paraffin	83-91	cathepsin B	Homo sapiens	65-76
12184920-2	2002	Immunohistochemical detection of IFI16 in paraffin-embedded tissues is achieved by using a polyclonal antibody raised against its C-terminal fragment that recognizes its three closely migrating isoforms in Western blotting.	Paraffin	42-50	interferon gamma inducible protein 16	Homo sapiens	33-38
12065876-2	2002	METHODS: The expression of p53 and mdm2 was analyzed by an immunohistochemical assay in 80 formalin-fixed paraffin embedded primary tumour samples and related to the clinical response to 5-fluorouracil therapy and to the prognosis of the patients.	Paraffin	106-114	MDM2 proto-oncogene	Homo sapiens	35-39
12498227-3	2002	Total heparan sulphate (HS) was detected with a monoclonal antibody to HSPG on paraffin sections.	Paraffin	79-87	syndecan 2	Homo sapiens	71-75
11776495-3	2001	METHODS: The expression of MGMT was immunohistochemically evaluated in 60, 62, 105, and 46 paraffin-embedded samples from patients with curatively resected hepatocellular, gastric, colorectal, and breast cancers, respectively.	Paraffin	91-99	O-6-methylguanine-DNA methyltransferase	Homo sapiens	27-31
11589429-2	2001	In the present study, we systematically analyzed the expression of MAP2 in a series of 237 human neuroepithelial tumors including paraffin-embedded specimens and tumor tissue microarrays from oligodendrogliomas, mixed gliomas, astrocytomas, glioblastomas, ependymomas, as well as dysembryoplastic neuroepithelial tumors (DNT), and central neurocytomas.	Paraffin	130-138	microtubule associated protein 2	Homo sapiens	67-71
11559559-3	2001	HLA-G expression was here investigated on paraffin-embedded tumor and adjacent normal renal tissues of 18 renal cell carcinoma (RCC) patients.	Paraffin	42-50	major histocompatibility complex, class I, G	Homo sapiens	0-5
11555602-4	2001	We used in situ hybridization to evaluate the expression of several metastasis-related genes, including MMP-9 and E-cadherin, in paraffin-embedded biopsy specimens from 55 patients with muscle-invasive TCC treated with neoadjuvant methotrexate, vinblastine, doxorubicin, and cisplatin chemotherapy and radical cystectomy.	Paraffin	129-137	matrix metallopeptidase 9	Homo sapiens	104-109
11712786-4	2001	In an effort to unravel molecular markers for non-responding nephroblastomas, we investigated by means of immunohistochemistty the expression of heat-shock protein 70 (HSP70) in formalin-fixed and paraffin-embedded tissue samples from 32 children afflicted with nephroblastoma.	Paraffin	197-205	heat shock protein family A (Hsp70) member 4	Homo sapiens	168-173
11274143-7	2001	Furthermore, paraffin sections of human osteoporotic fractured bone exhibited increased RANKL immunostaining in vivo on VEC located near resorbing OCs in regions undergoing active bone turnover.	Paraffin	13-21	TNF superfamily member 11	Homo sapiens	88-93
11350606-2	2001	Immunohistochemistry of paraffin-embedded liver sections with hyaluronidase pretreatment showed that HSPG was present in small amounts in normal liver around the bile ducts and the blood vessels within the portal area.	Paraffin	24-32	CD44 molecule (Indian blood group)	Homo sapiens	101-105
24578007-8	2000	Glut-1 expression was studied in terms of the immunohistochemistry of paraffin sections using anti-Glut-1 antibody to determine the intensity (0-3) of Glut-1 immunoreactivity and percentage of the Glut-1-positive area.	Paraffin	70-78	solute carrier family 2 member 1	Homo sapiens	0-6
11066074-0	2000	New comprehensive denaturing-gradient-gel- electrophoresis assay for KRAS mutation detection applied to paraffin-embedded tumours.	Paraffin	104-112	KRAS proto-oncogene, GTPase	Homo sapiens	69-73
11078571-8	2000	Because no material for biochemical testing was available we performed mutational analysis of the DHCR7 gene from paraffin-embedded tissue and a Guthrie card focusing on mutations known to cause a severe SLOS phenotype.	Paraffin	114-122	7-dehydrocholesterol reductase	Homo sapiens	98-103
11215196-7	2000	Herein, we also report the immunohistochemical study of paraffin-embedded specimens using anti-CEA, CA19-9, CA125 and p53 monoclonal antibodies.	Paraffin	56-64	mucin 16, cell surface associated	Homo sapiens	108-113
10993447-5	2000	METHODS: An immunohistochemical assay was performed to examine the expression of MMP-9 in 25 cases (formalin-fixed paraffin-embedded sections) of cholesteatoma, using an MMP-9-specific monoclonal antibody.	Paraffin	115-123	matrix metallopeptidase 9	Homo sapiens	81-86
10945497-0	2000	Monoclonal antibody MA454 reveals a heterogeneous expression pattern of MAGE-1 antigen in formalin-fixed paraffin embedded lung tumours.	Paraffin	105-113	MAGE family member A1	Homo sapiens	72-86
10878554-1	2000	This paper establishes a method of clonality analysis using the reverse transcription-polymerase chain reaction (RT-PCR) to amplify X-linked G6PD transcripts on defined cell populations microdissected from archival, paraffin-embedded tissue sections.	Paraffin	216-224	glucose-6-phosphate dehydrogenase	Homo sapiens	141-145
10841172-3	2000	We optimized the IHC procedure for the rat PTHR using 5-microm sections of paraffin-embedded rat kidney, liver, small intestine, uterus, and ovary.	Paraffin	75-83	parathyroid hormone 1 receptor	Rattus norvegicus	43-47
10897334-5	2000	RESULTS: MMP-9 expression was demonstrated in the malignant Hodgkin and Reed-Sternberg cells of all (n = 86) formalin fixed, paraffin wax embedded Hodgkin"s disease tumours examined.	Paraffin	125-137	matrix metallopeptidase 9	Homo sapiens	9-14
10800401-2	2000	We tested the value of a new commercially available monoclonal antibody against uroplakin III (clone AU 1) as a paraffin-reactive immunohistochemical marker for primary and metastatic urothelial carcinomas.	Paraffin	112-120	uroplakin 3A	Homo sapiens	80-93
10800401-7	2000	We found the new monoclonal antibody AU 1 against uroplakin III to be a highly specific paraffin-reactive immunohistochemical marker for urothelial tumors with a moderate sensitivity for the identification of primary and metastatic urothelial carcinomas.	Paraffin	88-96	uroplakin 3A	Homo sapiens	50-63
10803703-5	2000	The lymphoma cells were CD56+, CD45RO+, CD3+, CD4-, CD8-, CD20-, and CD30- in paraffin sections with germline configuration of TCR-gamma gene, consistent with T/NK-cell lymphoma.	Paraffin	78-86	TNF receptor superfamily member 8	Homo sapiens	69-73
10822330-4	2000	This study demonstrates the successful use of PCR techniques to isolate host CCR5 and CCR2b, and HIV-1 V3 sequences from paraffin embedded tissues from patients with and without ADC.	Paraffin	121-129	C-C motif chemokine receptor 5	Homo sapiens	77-81
10804289-3	2000	The expression of CD44 isoforms was evaluated immunohistochemically in paraffin-embedded tissues from 89 primary lesions, using monoclonal antibodies against CD44 standard (CD44st), CD44 variant 6 (CD44v6) and CD44v2.	Paraffin	71-79	CD44 molecule (Indian blood group)	Homo sapiens	18-22
11776642-2	2000	METHODS: The expression of MAGE-3 antigen was examined in formalin fixed, paraffin embedded sections of NSCLC by LSAB immunohistochemical technique.	Paraffin	74-82	MAGE family member A3	Homo sapiens	27-41
10672059-5	2000	Monoclonal antibodies effective in formalin-fixed, paraffin-embedded tissue were successfully generated, designated NCL-CD5-4C7, NCL-CD10-270 and NCL-CD23-1B12, respectively.	Paraffin	51-59	nucleolin	Mus musculus	116-119
10658907-0	2000	Detection of the ETV6-NTRK3 chimeric RNA of infantile fibrosarcoma/cellular congenital mesoblastic nephroma in paraffin-embedded tissue: application to challenging pediatric renal stromal tumors.	Paraffin	111-119	neurotrophic receptor tyrosine kinase 3	Homo sapiens	22-27
10658907-1	2000	We report the development of a reverse transcriptase polymerase chain reaction assay that reliably detects the ETV6-NTRK3 chimeric RNA characteristic of infantile fibrosarcoma and the cellular variant of congenital mesoblastic nephroma (CMN) in formalin-fixed, paraffin-embedded tissue blocks.	Paraffin	261-269	neurotrophic receptor tyrosine kinase 3	Homo sapiens	116-121
10493979-4	1999	Immunohistochemical staining for FAS was performed on formaline-fixed, paraffin-embedded sections.	Paraffin	71-79	fatty acid synthase	Homo sapiens	33-36
10496599-2	1999	A retrospective immunohistochemical study was undertaken to determine the frequency of immunoreactivity of Ber-H2 (anti-CD30 monoclonal antibody) in malignant melanoma Archival paraffin-embedded tissue from 24 primary and metastatic lesions was used.	Paraffin	177-185	TNF receptor superfamily member 8	Homo sapiens	120-124
10443672-4	1999	We raised antipeptide antibodies against GDF-9 and showed by immunohistochemical studies on paraffin sections of whole human ovaries that the GDF-9 protein is most abundantly expressed in primary follicles.	Paraffin	92-100	growth differentiation factor 9	Homo sapiens	142-147
10406836-10	1999	Sections of paraffin-embedded arteries were fixed on slides, and the expression of c-fos was determined by in situ hybridization with the use of (35)S-labeled riboprobes.	Paraffin	12-20	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	83-88
10442317-1	1999	OBJECTIVE: To determine the integrity of the BRCA1 gene in archival, paraffin-embedded tissues from precancerous lesions of the uterine cervix.	Paraffin	69-77	BRCA1 DNA repair associated	Homo sapiens	45-50
10748551-6	1999	Since FB1 and FB21 can be used with formalin-fixed paraffin-embedded tissue sections, they are useful for diagnosis of B cell lymphoma or thyroid carcinoma.	Paraffin	51-59	TCF3 fusion partner	Homo sapiens	6-9
10208461-6	1999	MATERIALS AND METHODS: Formalin-fixed paraffin sections were used for immunostaining of Bcl-6.	Paraffin	38-46	BCL6 transcription repressor	Homo sapiens	88-93
10087311-3	1999	The localization of BRCA1 in the 2 groups was performed using polyclonal antibodies (K-18; C-20; D-20; I-20) raised against BRCA1 and by comparing frozen and paraffin-embedded tissues.	Paraffin	158-166	BRCA1 DNA repair associated	Homo sapiens	20-25
10071144-5	1999	METHODS: We analyzed six paraffin-embedded conjunctival melanomas for mutations of the N-ras gene.	Paraffin	25-33	NRAS proto-oncogene, GTPase	Homo sapiens	87-92
10082252-2	1999	Synaptophysin immunoreactivity was studied in paraffin-embedded sections of the central nervous system (CNS) in 14 normal human fetuses and neonates ranging in age from 8 to 41 weeks gestation, and in three brains with heterotopic neurons or malformations.	Paraffin	46-54	synaptophysin	Homo sapiens	0-13
10609497-2	1999	The presence of the predominant Jewish BRCA1 and BRCA2 mutations in archival paraffin-embedded tumor tissue of four Jewish women with ovarian carcinoma who previously underwent ovulation induction with clomiphene citrate, was determined.	Paraffin	77-85	BRCA1 DNA repair associated	Homo sapiens	39-44
10609497-2	1999	The presence of the predominant Jewish BRCA1 and BRCA2 mutations in archival paraffin-embedded tumor tissue of four Jewish women with ovarian carcinoma who previously underwent ovulation induction with clomiphene citrate, was determined.	Paraffin	77-85	BRCA2 DNA repair associated	Homo sapiens	49-54
10430474-0	1999	Detection and quantification of hippocampal synaptophysin messenger RNA in schizophrenia using autoclaved, formalin-fixed, paraffin wax-embedded sections.	Paraffin	123-135	synaptophysin	Homo sapiens	44-57
9809029-0	1998	Mutations in BRCA1 from fixed, paraffin-embedded tissue can be artifacts of preservation.	Paraffin	31-39	BRCA1 DNA repair associated	Homo sapiens	13-18
9924344-4	1998	METHODS: Standard light microscopic immunocytochemistry, including antigen retrieval, was used to localise TIMP-3 in paraffin sections of human eyes: two with SFD, three with different genetic forms of RP, and two normal.	Paraffin	117-125	TIMP metallopeptidase inhibitor 3	Homo sapiens	107-113
21206358-1	1998	CD44 expression was investigated immunohistochemically on paraffin sections obtained from 88 uterine cervical cancers and 31 normal cervices, using monoclonal antibodies against CD44 variant epitopes v4, v5, v6, v7/8, v9 and the standard form of the CD44 protein.	Paraffin	58-66	CD44 molecule (Indian blood group)	Homo sapiens	0-4
9776278-5	1998	The GLUT-1 expression was studied by immunohistochemistry of paraffin sections from these tumors after the operation using the antiGLUT-1 antibody.	Paraffin	61-69	solute carrier family 2 member 1	Homo sapiens	4-10
9683786-4	1998	Antigen retrieval methods on formalin-fixed, paraffin-embedded specimens produced tumor cell cytoplasmic staining with AP 16 and nuclear staining in both tumor and normal epithelial cells with another BRCA1 monoclonal antibody, SG 11.	Paraffin	45-53	BRCA1 DNA repair associated	Homo sapiens	201-206
9706977-3	1998	In this study, we evaluated Melan-A expression immunohistochemically on sections from paraffin-embedded material of 50 benign nevi and 40 primary cutaneous melanomas using the monoclonal antibody A103.	Paraffin	86-94	melan-A	Homo sapiens	28-35
9719446-6	1998	Based on this antibody, we developed an immunohistochemical method suitable for studying VDR expression in paraffin-embedded tissue.	Paraffin	107-115	vitamin D receptor	Homo sapiens	89-92
9719446-8	1998	With this method, we studied VDR localization on paraffin-embedded human prostatic tissue obtained from 8 patients undergoing radical prostatectomy for urinary bladder cancer and demonstrate VDR expression in the secretory epithelial and few stromal cells of human prostate.	Paraffin	49-57	vitamin D receptor	Homo sapiens	29-32
9764809-0	1998	Melan A/MART-1 immunoreactivity in formalin-fixed paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Paraffin	50-58	melan-A	Homo sapiens	0-7
9764809-0	1998	Melan A/MART-1 immunoreactivity in formalin-fixed paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Paraffin	50-58	melan-A	Homo sapiens	8-14
9539209-12	1998	A feature of cholinergic neurons of the central nervous system revealed clearly with vesicular acetylcholine transporter immunohistochemistry in paraffin-embedded sections is the termination of cholinergic neurons on cholinergic cell bodies.	Paraffin	145-153	solute carrier family 18 member A3	Rattus norvegicus	85-120
9531892-2	1998	DESIGN: Standard immunohistochemical staining using a rabbit polyclonal antibody against the tau isoform of the cAMP responsive element modulator protein was performed on 5-microM sections of Bouin"s fixed, paraffin-embedded testicular tissue obtained from azoospermic or severely oligozoospermic men for routine clinical purposes.	Paraffin	207-215	cAMP responsive element modulator	Homo sapiens	112-145
9531892-6	1998	INTERVENTION(S): Rabbit polyclonal cAMP responsive element modulator tau antibody was applied to the paraffin-embedded testis sections.	Paraffin	101-109	cAMP responsive element modulator	Homo sapiens	35-68
9372320-4	1997	METHODS: CD 54 was detected in paraffin sections by monoclonal antibodies after an autoclaving pretreatment using the ABC peroxidase technique.	Paraffin	31-39	intercellular adhesion molecule 1	Homo sapiens	9-14
9211488-6	1997	A simple and nonradio-active PCR/RFLP-based method for detection of K-ras codon 12 mutations in formalin-fixed, paraffin-embedded tissue sections of pancreatic adenocarcinoma is described and compared to the traditional PCR technique.	Paraffin	112-120	KRAS proto-oncogene, GTPase	Homo sapiens	68-73
9216653-4	1997	Apoptosis was assayed using the terminal deoxynucleotidyl transferase (TdT)-mediated deoxyuridine triphosphate (dUTP)-biotin nick end labeling method in paraffin-embedded tissue sections, and by flow-cytometric analysis.	Paraffin	153-161	DNA nucleotidylexotransferase	Homo sapiens	71-74
9183080-2	1997	PI was determined by avidin-biotin-complex immunostaining after high temperature microwave antigen retrieval in paraffin sections, using monoclonal MIB-1 antibody which detects paraffin resistant analogue of cell cycle-associated Ki-67 antigen.	Paraffin	177-185	MIB E3 ubiquitin protein ligase 1	Homo sapiens	148-153
9227346-0	1997	Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections: a useful method for the diagnosis of lymphoblastic lymphoma.	Paraffin	73-81	DNA nucleotidylexotransferase	Homo sapiens	0-37
9227346-3	1997	Until the recent development of the use of microwave-treated paraffin sections for immunoperoxidase staining, detection of TdT in paraffin sections required rather complicated processes.	Paraffin	61-69	DNA nucleotidylexotransferase	Homo sapiens	123-126
9227346-3	1997	Until the recent development of the use of microwave-treated paraffin sections for immunoperoxidase staining, detection of TdT in paraffin sections required rather complicated processes.	Paraffin	130-138	DNA nucleotidylexotransferase	Homo sapiens	123-126
19240792-6	2009	ASB-PCR can be used for detection of germ line or somatic mutations in either DNA or RNA extracted from any type of tissue, including formalin-fixed paraffin-embedded tumor specimens.	Paraffin	149-157	arylsulfatase B	Homo sapiens	0-3
9227346-8	1997	These results show that the immunostaining of TdT on paraffin-embedded sections is a useful method for differentiating lymphoblastic lymphoma from other lymphomas.	Paraffin	53-61	DNA nucleotidylexotransferase	Homo sapiens	46-49
18800350-4	2008	K-ras mutation was detected by cycle sequencing of polymerase chain reaction (PCR)-amplified DNA, isolated from formalin-fixed, paraffin-embedded lung tumors.	Paraffin	128-136	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-5
9124809-7	1997	There was selective expression in paraffin-embedded sections of alpha B-crystallin (CRYA2) in oligodendroglia in all areas of the nervous system examined.	Paraffin	34-42	crystallin alpha B	Homo sapiens	84-89
9124576-3	1997	In situ hybridization using a hamster-specific TGF-alpha riboprobe was done on paraffin sections.	Paraffin	79-87	transforming growth factor alpha	Rattus norvegicus	47-56
18980995-6	2008	Immunohistochemical analysis showed that 100 of 243 (41.2%) paraffin-embedded archival astrocytoma biopsies exhibited high expression of SPHK1.	Paraffin	60-68	sphingosine kinase 1	Homo sapiens	137-142
9028355-9	1997	Using univariate analysis, the presence of K-ras mutation in paraffin embedded tissue from patients who received treatment with curative intent was associated with a shorter survival (P = 0.039).	Paraffin	61-69	KRAS proto-oncogene, GTPase	Homo sapiens	43-48
9209651-4	1997	PG-B6p (p = paraffin) reacted with an epitope of bcl-6 partially resistant to fixatives and detectable on microwave-heated paraffin sections.	Paraffin	12-20	BCL6 transcription repressor	Homo sapiens	49-54
18681860-3	2008	DESIGN: We investigated the expression of CLA using the HECA-452 antibody on paraffin-embedded, formalin-fixed tissue in a variety of reactive, neoplastic and preneoplastic cutaneous lymphoid infiltrates of T- and B-cell derivation.	Paraffin	77-85	selectin P ligand	Homo sapiens	42-45
9209651-4	1997	PG-B6p (p = paraffin) reacted with an epitope of bcl-6 partially resistant to fixatives and detectable on microwave-heated paraffin sections.	Paraffin	123-131	BCL6 transcription repressor	Homo sapiens	49-54
9387011-2	1997	ICAM-1 was detected in paraffin sections after autoclaving and using the ABC technique in 86% of the wounds investigated.	Paraffin	23-31	intercellular adhesion molecule 1	Homo sapiens	0-6
18774544-3	2008	During our research, CD147 expression in 156 patients who underwent operation for DTC [100 with papillary thyroid carcinoma (PTC) and 56 with follicular thyroid carcinoma (FTC)] were examined by immunostaining on paraffin-embedded tumor specimens.	Paraffin	213-221	basigin (Ok blood group)	Homo sapiens	21-26
9027631-0	1997	Detection of CD44 splice variants in formalin-fixed, paraffin-embedded specimens of human skin cancer.	Paraffin	53-61	CD44 molecule (Indian blood group)	Homo sapiens	13-17
9027631-3	1997	We wished to develop a technique to unmask chemically CD44s and CD44v epitopes in paraffin-embedded specimens of human skin cancers, so that they would be accessible for these mAbs.	Paraffin	82-90	CD44 molecule (Indian blood group)	Homo sapiens	54-58
9087919-9	1997	The results showed a high specificity and high sensitivity for detecting hog cholera Gp55 in formalin-fixed, paraffin embedded tissue samples.	Paraffin	109-117	neuroplastin	Homo sapiens	85-89
18763281-8	2008	Moreover, the negative CHFR protein expression rate in paraffin-embedded GC samples was 55.07% (38/69), the positive rate in poorly differentiated GC samples was 36.73% (18/49), which was significantly lower than 65.00% (13/20) in well-differentiated GC samples (c2 = 4.586, P = 0.032).	Paraffin	55-63	checkpoint with forkhead and ring finger domains	Homo sapiens	23-27
9521509-1	1997	The immunohistological expression of p53 and MDM2 oncoproteins was examined in paraffin embedded tissue from 106 patients with transitional cell carcinoma of the urinary bladder and was related to various clinicopathological features, the expression of proliferation associated markers (proliferating cell nuclear antigen - PCNA - and Ki-67), c-erb B-2 oncoprotein and epidermal growth factor receptor (EGFR), as well as to survival.	Paraffin	79-87	MDM2 proto-oncogene	Homo sapiens	45-49
18701502-3	2008	We thus evaluated CBX7 expression in various snap-frozen and paraffin-embedded thyroid carcinoma tissues of different degrees of malignancy by quantitative reverse transcription-PCR and immunohistochemistry, respectively.	Paraffin	61-69	chromobox 7	Homo sapiens	18-22
8929264-4	1996	METHODS: The expression of DCC was evaluated immunohistochemically in 132 paraffin-embedded samples from patients with curatively resected stage II and III colorectal carcinomas.	Paraffin	74-82	DCC netrin 1 receptor	Homo sapiens	27-30
8958300-3	1996	Immunohistochemical expression of CD44 (standard [s] and variant [v6]) in benign and malignant nevomelanocytic lesions was assessed in formalin-fixed, paraffin-embedded tissue and was correlated with histological parameters and prognostic factors.	Paraffin	151-159	CD44 antigen	Mus musculus	34-38
18676751-3	2008	EXPERIMENTAL DESIGN: Immunohistochemistry for B7-H1, B7-H3, and PD-1 was done on paraffin-embedded sections from 318 consecutive patients with UCC who underwent radical cystectomy.	Paraffin	81-89	CD274 molecule	Homo sapiens	46-68
8996705-1	1996	Immunohistochemical detection of rat CAR bacillus antigen in paraffin-embedded experimentally infected rat lungs, using an immunoperoxidase technique based on the labelled streptavidin biotin (LSAB) method and 3-amino-9-ethylcarbazole (AEC) as substrate is described in this paper.	Paraffin	61-69	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	37-40
18648094-3	2008	K-ras and p53 mutations were detected by cycle sequencing of PCR-amplified DNA isolated from paraffin-embedded neoplasms.	Paraffin	93-101	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	0-5
8933108-4	1996	Application examples are shown in which the K-ras status was examined in peripheral blood cells, cell cultures, fresh and paraffin-embedded tumour tissue and in stool samples.	Paraffin	122-130	KRAS proto-oncogene, GTPase	Homo sapiens	44-49
18648094-3	2008	K-ras and p53 mutations were detected by cycle sequencing of PCR-amplified DNA isolated from paraffin-embedded neoplasms.	Paraffin	93-101	transformation related protein 53, pseudogene	Mus musculus	10-13
18581137-0	2008	Reduced mRNA expression in paraffin-embedded tissue identifies MLH1- and MSH2-deficient colorectal tumours and potential mutation carriers.	Paraffin	27-35	mutL homolog 1	Homo sapiens	63-67
8917707-0	1996	The tumour-associated antigen MAGE-1 is detectable in formalin-fixed paraffin sections of malignant melanoma.	Paraffin	69-77	MAGE family member A1	Homo sapiens	30-36
9009679-3	1996	Paraffin fixed specimens of benign and malignant neoplasia, occurring in patients with NF1 and NF2, were tested for the presence of p53: a reliable marker of genetic oncosupression.	Paraffin	0-8	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	95-98
8701996-4	1996	Myelin in the central and peripheral nervous systems was strongly stained with a monoclonal antibody against human CD9 antigen in paraffin-embedded sections.	Paraffin	130-138	CD9 molecule	Homo sapiens	115-126
8703557-2	1996	Immunohistochemical detection using MIB-1 monoclonal antibody has recently allowed us to assess tumor cell proliferation easily, because it can be performed on paraffin-embedded specimens and the results have been demonstrated to be positively correlated with the results of PCNA staining.	Paraffin	160-168	MIB E3 ubiquitin protein ligase 1	Homo sapiens	36-41
8691318-3	1996	This study investigated the prognostic value of the proliferation marker MIB-1 (paraffin Ki-67) in 59 neuroendocrine lung tumours (32 SCLC, 13 WDNEC, 14 CD) by immunostaining of routinely processed paraffin sections.	Paraffin	80-88	MIB E3 ubiquitin protein ligase 1	Homo sapiens	73-78
8857669-1	1996	Immunohistochemical localization of tyrosinase was examined with a monoclonal antibody (MoAb MAT-1) against human tyrosinase on routine formalin-fixed paraffin-embedded sections of 3 normal skin specimens, 15 melanocytic tumors (6 pigmented nevi, 3 juvenile melanomas and 6 malignant melanomas) and 3 non-melanocytic tumors.	Paraffin	151-159	tyrosinase	Homo sapiens	36-46
8605566-7	1996	We therefore performed triple-colour fluorescence in situ hybridization (FISH) for portions of the bcr and abl genes flanking the breakpoint in CML in paraffin sections of CML cases with normal and with increased numbers of megakaryocytes.	Paraffin	151-159	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	107-110
11885252-1	1996	In order to establish whether tissues damaged by Chronic Periapical Pathology (CPP) of endodontic origin produced heat shock protein (HSP) capable of attracting reactive lymphocytes, paraffin sections of samples from the oral cavity of 10 patients with CPP were incubated with commercially available anti-HSP monoclonal antibodies.	Paraffin	183-191	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	114-132
11885252-1	1996	In order to establish whether tissues damaged by Chronic Periapical Pathology (CPP) of endodontic origin produced heat shock protein (HSP) capable of attracting reactive lymphocytes, paraffin sections of samples from the oral cavity of 10 patients with CPP were incubated with commercially available anti-HSP monoclonal antibodies.	Paraffin	183-191	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	134-137
8645458-3	1996	The expression of CA-125 was studied in paraffin-embedded tissue from 48 mammary carcinomas and 11 samples of normal mammary gland using two monoclonal antibodies, M2 and M11.	Paraffin	40-48	mucin 16, cell surface associated	Homo sapiens	18-24
8737784-3	1996	In order to locate the mitochondrial O2- scavenging enzyme, manganese superoxide dismutase (MnSOD), the authors used a modified immunoglobulin peroxidase bridge sequence method to detect MnSOD in paraffin-embedded, formalin-fixed rat cochleas.	Paraffin	196-204	superoxide dismutase 2	Rattus norvegicus	60-90
8737784-3	1996	In order to locate the mitochondrial O2- scavenging enzyme, manganese superoxide dismutase (MnSOD), the authors used a modified immunoglobulin peroxidase bridge sequence method to detect MnSOD in paraffin-embedded, formalin-fixed rat cochleas.	Paraffin	196-204	superoxide dismutase 2	Rattus norvegicus	92-97
8737784-3	1996	In order to locate the mitochondrial O2- scavenging enzyme, manganese superoxide dismutase (MnSOD), the authors used a modified immunoglobulin peroxidase bridge sequence method to detect MnSOD in paraffin-embedded, formalin-fixed rat cochleas.	Paraffin	196-204	superoxide dismutase 2	Rattus norvegicus	187-192
8543315-8	1996	Genetic analysis using DNA extracted from paraffin sections of metastatic lesions revealed mutation of K-ras codon 12.	Paraffin	42-50	KRAS proto-oncogene, GTPase	Homo sapiens	103-108
9097711-8	1996	The results suggest that MIB-1 antibody is an excellent tool for assessment of proliferative rate of breast cancer cells in paraffin sections.	Paraffin	124-132	MIB E3 ubiquitin protein ligase 1	Homo sapiens	25-30
8634783-0	1995	A universal method for the mutational analysis of K-ras and p53 gene in non-small-cell lung cancer using formalin-fixed paraffin-embedded tissue.	Paraffin	120-128	KRAS proto-oncogene, GTPase	Homo sapiens	50-55
8762479-1	1995	By using a modified polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) technique, we detected K-ras codon 12 mutation in 102 formalin-fixed, paraffin-embedded tissues from surgical samples of lung cancer patients.	Paraffin	174-182	KRAS proto-oncogene, GTPase	Homo sapiens	127-132
8600794-1	1995	Immunohistochemical study using the MIB 1 antibody in formalin-fixed paraffin sections.	Paraffin	69-77	MIB E3 ubiquitin protein ligase 1	Homo sapiens	36-41
7675770-1	1995	Microwave heating of formalin-fixed, paraffin embedded tissue sections in citrate buffer (MHC) has been shown recently to enhance the antigenicity of a number of formalin-sensitive epitopes.	Paraffin	37-45	major histocompatibility complex, class I, C	Homo sapiens	90-93
7675770-8	1995	We concluded that MHC facilitates the recognition of diagnostically important antigens in formalin-fixed, paraffin-embedded tissue and can be applied routinely without adverse affects.	Paraffin	106-114	major histocompatibility complex, class I, C	Homo sapiens	18-21
7887887-2	1995	We observed the presence of a mutated beta-MHC mRNA in a formalin-fixed paraffin-embedded myocardial tissue of a proband from family A, which Geisterfer-Lowrance et al.	Paraffin	72-80	major histocompatibility complex, class I, C	Homo sapiens	43-46
7633653-3	1995	The development of an antibody directed against parts of the Ki-67 antigen (MIB-1) has opened a new route to determine the proliferative activity on paraffin sections (PS).	Paraffin	149-157	MIB E3 ubiquitin protein ligase 1	Homo sapiens	76-81
7982181-3	1994	Recently, monoclonal antibody to Ki67 (MIB1), a nuclear protein related to cell proliferation, has been analyzed immunohistochemically using tissue prepared from paraffin embedded sections.	Paraffin	162-170	MIB E3 ubiquitin protein ligase 1	Homo sapiens	39-43
7523275-2	1994	The expression of CD44 in 23 gastric adenocarcinoma and 12 peptic ulcer disease (PUD) resection specimens and gastric carcinoma cell lines HS746t and KATO III was examined by immunohistochemistry using the murine monoclonal antibody A3D8 on formalin-fixed, paraffin-embedded tissue or cells.	Paraffin	257-265	CD44 molecule (Indian blood group)	Homo sapiens	18-22
8088769-0	1994	Prognostic significance of cell proliferation in mucoepidermoid carcinomas of the salivary gland: clinicopathological study using MIB 1 antibody in paraffin sections.	Paraffin	148-156	MIB E3 ubiquitin protein ligase 1	Homo sapiens	130-135
7980952-2	1994	This was investigated by determining the expression of SF/HGF in various regions of the murine male genital tract by scatter and cell tracking assays using MDCK epithelial cells, Western blot procedure, and the immunohistochemical procedure using paraffin sections of various regions of the male genital tract.	Paraffin	247-255	hepatocyte growth factor	Mus musculus	55-61
7918836-1	1994	A new antibody (MIB-1) has been described, permitting the demonstration of Ki-67 proliferation antigen in paraffin sections.	Paraffin	106-114	MIB E3 ubiquitin protein ligase 1	Homo sapiens	16-21
21607449-7	1994	At immunohistochemistry, in paraffin sections, there was strong positivity with the reagents against CD45, CD68, alfa-1-antichymotrypsin and vimentin.	Paraffin	28-36	protein tyrosine phosphatase receptor type C	Homo sapiens	101-105
21607449-7	1994	At immunohistochemistry, in paraffin sections, there was strong positivity with the reagents against CD45, CD68, alfa-1-antichymotrypsin and vimentin.	Paraffin	28-36	CD68 molecule	Homo sapiens	107-111
7526883-2	1994	Monoclonal antibody specific to human tenascin was applied to paraffin sections by the avidin-biotin-complex method to examine its localization.	Paraffin	62-70	tenascin C	Homo sapiens	38-46
7520586-7	1994	Reactivity for LMP was demonstrated in cryostat sections and was also well preserved in paraffin sections of B5- or formalin-fixed tissues.	Paraffin	88-96	PDZ and LIM domain 7	Homo sapiens	15-18
21607406-4	1994	In this study we examined the incidence of H-, K- and N-ras mutations in 47 DNA samples isolated from paraffin-embedded 25 cutaneous and 22 uveal malignant melanoma tissues and a MeWo melanoma cell line using the Restriction Fragment Length Polymorphism (RFLP) analysis of PCR products.	Paraffin	102-110	NRAS proto-oncogene, GTPase	Homo sapiens	43-59
8053129-0	1994	Distribution of anti-CD68 (EBM11) immunoreactivity in formalin-fixed, paraffin-embedded bovine tissues.	Paraffin	70-78	CD68 molecule	Bos taurus	21-25
7906221-1	1994	Proliferating cell nuclear antigen (PCNA) is a nuclear protein maximally elevated in the S phase of proliferating and transformed cells and is recognized by the monoclonal antibody PC-10 in paraffin tissue sections.	Paraffin	190-198	proliferating cell nuclear antigen	Rattus norvegicus	0-34
7906221-1	1994	Proliferating cell nuclear antigen (PCNA) is a nuclear protein maximally elevated in the S phase of proliferating and transformed cells and is recognized by the monoclonal antibody PC-10 in paraffin tissue sections.	Paraffin	190-198	proliferating cell nuclear antigen	Rattus norvegicus	36-40
7906221-3	1994	The expression of PCNA in rat liver after partial hepatectomy was performed by immunohistochemical staining with PC-10 in paraffin embedded tissues, at different time intervals up to 240 hr.	Paraffin	122-130	proliferating cell nuclear antigen	Rattus norvegicus	18-22
7947334-0	1994	Determination of ABO genotypes with DNA extracted from formalin-fixed, paraffin-embedded tissues.	Paraffin	71-79	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	17-20
7931823-2	1994	NCL-DK4 has been proved to be highly effective for use on formalin-fixed, paraffin-embedded tissues, enabling the study of c-jun expression at a cellular level in both normal and neoplastic human tissues.	Paraffin	74-82	immunoglobulin heavy diversity 5-5	Homo sapiens	4-7
7905542-6	1994	PI by PCNA/MIB1 was established using 5-microns paraffin sections, immunoperoxidase, and quantification procedures detailed in the literature.	Paraffin	48-56	MIB E3 ubiquitin protein ligase 1	Homo sapiens	11-15
7518292-1	1994	The expression and distribution of tenascin, an extracellular matrix glycoprotein, was investigated immunohistochemically using an anti-human tenascin monoclonal antibody (RCB 1) in formalin-fixed paraffin-embedded tissues obtained from 79 patients with skin appendage tumours, and compared with adjacent normal skin.	Paraffin	197-205	tenascin C	Homo sapiens	35-43
8287627-10	1993	We conclude that synapsin I is a reliable, sensitive immunohistochemical marker for neuronal/neuroendocrine differentiation in human neoplasms and may offer some advantages over synaptophysin when applied to formalin-fixed, paraffin-embedded tissues, particularly in the evaluation of primitive neuroectodermal tumors and neuroendocrine tumors.	Paraffin	224-232	synapsin I	Homo sapiens	17-27
8342602-10	1993	These results demonstrate that primer-mediated, mutant-enriched polymerase chain reaction-restriction fragment length polymorphism analysis combined with allele-specific oligonucleotide hybridization can be used to detect and characterize mutations in codon 12 of the K-ras oncogene in formalin-fixed, paraffin-embedded tissues, and the results confirm that activating point mutations in codon 12 of the K-ras oncogene occur frequently in adenocarcinomas of the pancreas.	Paraffin	302-310	KRAS proto-oncogene, GTPase	Homo sapiens	268-273
8157747-8	1993	Commonly occurring mutations in the K-ras gene--in the first two positions of codon 12--could easily be detected in DNA from archival paraffin wax embedded colon cancer tissue.	Paraffin	134-146	KRAS proto-oncogene, GTPase	Homo sapiens	36-41
8325958-4	1993	Using paraffin brain sections and immunohistochemical analysis, in the preterm (24-25 weeks) and term (40 weeks) infant, similar to the adult we demonstrated the presence of Glut 1 in microvascular endothelial cells which constitute blood-brain barrier forming cells.	Paraffin	6-14	solute carrier family 2 member 1	Homo sapiens	174-180
7685843-11	1993	In addition, after antigen unmasking by microwave treatment, MIB 1 and MIB 3 detect the Ki-67 antigen in paraffin sections.	Paraffin	105-113	MIB E3 ubiquitin protein ligase 1	Homo sapiens	61-66
7684238-5	1993	By pretreatment of the paraffin-embedded tissue sections with pepsin, the distribution of tenascin was often intensified considerably and distinct localisation was more clearly demonstrated in the colonic tumour tissues.	Paraffin	23-31	tenascin C	Homo sapiens	90-98
8492470-1	1993	The point mutation of K-ras gene at codon 12 was investigated in 11 cases of gall bladder carcinoma, 10 cases of extrahepatic bile duct carcinoma, 2 cases of intrahepatic bile duct carcinoma, and 4 cases of ampullary carcinoma by modified two-step polymerase chain reaction which employed paraffin embedded materials.	Paraffin	289-297	KRAS proto-oncogene, GTPase	Homo sapiens	22-27
8385060-3	1993	METHODS: Paraffin-embedded tissue samples from 32 cases of invasive adenocarcinoma of the endocervix were analyzed for the presence of c-Ki-ras mutations by amplification of DNA extracted from paraffin blocks using the polymerase chain reaction (PCR) and subsequent restriction enzyme digestion of the amplimers.	Paraffin	193-201	KRAS proto-oncogene, GTPase	Homo sapiens	135-143
1625992-3	1992	Synaptophysin proved to be the most reliable tumor cell marker on both snap-frozen and paraffin-embedded tissue but, like antibodies against NSE, yielded unspecific stainings in the carcinomas.	Paraffin	87-95	synaptophysin	Homo sapiens	0-13
1547538-1	1992	The cell-type-specific expression of human O6-methylguanine-DNA methyltransferase (O6-MT) was determined in paraffin-embedded sections of human kidney.	Paraffin	108-116	O-6-methylguanine-DNA methyltransferase	Homo sapiens	43-81
1547538-1	1992	The cell-type-specific expression of human O6-methylguanine-DNA methyltransferase (O6-MT) was determined in paraffin-embedded sections of human kidney.	Paraffin	108-116	O-6-methylguanine-DNA methyltransferase	Homo sapiens	83-88
1323601-6	1992	In another patient the same mutation in codon 61 of the N-ras gene was found in cirrhotic liver tissue and in all four patients the same mutation was also detected in formalin-fixed, paraffin-embedded liver biopsy HCC tissue obtained at diagnosis.	Paraffin	183-191	NRAS proto-oncogene, GTPase	Homo sapiens	56-61
29535532-8	2018	Consistently, IHC revealed increased expression of DCLK1 in PCa paraffin-embedded tissues compared with BPH.	Paraffin	64-72	doublecortin like kinase 1	Homo sapiens	51-56
29406891-0	2018	Demyelination with preferential MAG loss: A complex message from MS paraffin blocks.	Paraffin	68-76	myelin associated glycoprotein	Homo sapiens	32-35
29308052-7	2018	The CRMP4 promotor methylation level in paraffin-embedded tissues of the 10 patients with PMLP were determined and then compared to limited prostate cancer (LPCa) and its negative lymph node tissue [LPCa-LN (-) (10 cases)] and also to metastatic prostate adenocarcinoma (mPCa) and its positive lymph node tissue [mPCa-LN (+) (10 cases)].	Paraffin	40-48	dihydropyrimidinase like 3	Homo sapiens	4-9
28990097-3	2017	By detecting FBP1 protein expression in paraffin-embedded tumor tissues through immunohistochemistry, it was observed that 50% of the cases had a low expression of FBP1, which was associated with a shorter overall survival time (P=0.011).	Paraffin	40-48	fructose-bisphosphatase 1	Homo sapiens	13-17
29093617-3	2017	KRAS mutational status was determined by pyrosequencing analysis of DNA obtained from formalin-fixed paraffin-embedded (FFPE) tumor tissues.	Paraffin	101-109	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
27556822-4	2017	SDHB IHC was performed on formalin-fixed, paraffin-embedded tissue sections with a mouse monoclonal antibody (Abcam 21A11AE7) in parallel with histochemical SDH stains on a fresh-frozen tissue.	Paraffin	42-50	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	0-4
28627450-2	2017	The most sensitive assays for KRAS mutation detection in formalin-fixed paraffin embedded (FFPE) tissues are based on real-time PCR.	Paraffin	72-80	KRAS proto-oncogene, GTPase	Homo sapiens	30-34
28727276-4	2017	Paraffin-embedded lung tissue samples were used to detect miRNA-21 and miRNA-155.	Paraffin	0-8	microRNA 155	Homo sapiens	71-80
28740441-6	2017	Extractive molecular assays are expensive and laborious methods, but they specifically recognize almost all ROS1 fusions using a limited amount of mRNA even from formalin-fixed, paraffin-embedded tumor tissues.	Paraffin	178-186	ROS proto-oncogene 1, receptor tyrosine kinase	Homo sapiens	108-112
28637493-5	2017	NLRP3 and Ki-67 expression in paraffin-embedded OSCC tissues was determined by immunohistochemistry.	Paraffin	30-38	antigen identified by monoclonal antibody Ki 67	Mus musculus	10-15
28393234-3	2017	TNFAIP2 mRNA and protein expression levels were examined by qRT-PCR and immunohistochemical analysis in 24 fresh and 55 paraffin-embedded specimens, respectively.	Paraffin	120-128	TNF alpha induced protein 2	Homo sapiens	0-7
28405687-6	2017	GINS2 protein expression in 155 paraffin-embedded cervical cancer specimens was validated using immunohistochemistry.	Paraffin	32-40	GINS complex subunit 2	Homo sapiens	0-5
28471195-13	2017	CONCLUSION: During development of PLA method for detection of protein complexes between p53 family members we detected interactions of p53 and p63 with T-antigen and mut-p53 and DeltaNp63 with TAp73 tumour suppressor in tumour cell lines and p53 tetramers in paraffin sections of colorectal cancer tissue.	Paraffin	259-267	methylmalonyl-CoA mutase	Homo sapiens	152-169
28073897-0	2017	Identification of ALK, ROS1, and RET Fusions by a Multiplexed mRNA-Based Assay in Formalin-Fixed, Paraffin-Embedded Samples from Advanced Non-Small-Cell Lung Cancer Patients.	Paraffin	98-106	ALK receptor tyrosine kinase	Homo sapiens	18-21
27940396-4	2017	Expression of KISS-1 protein was analyzed immunohistochemically in formalin-fixed, paraffin-embedded adenomyotic tissue specimens (n=29), matched eutopic endometrium from the same patients (n=29) and normal endometrium from patients without adenomyosis (n=29).	Paraffin	83-91	KiSS-1 metastasis suppressor	Homo sapiens	14-20
28201998-0	2017	Clinical performance evaluation of a sensitive, rapid low-throughput test for KRAS mutation analysis using formalin-fixed, paraffin-embedded tissue samples.	Paraffin	123-131	KRAS proto-oncogene, GTPase	Homo sapiens	78-82
28201998-1	2017	BACKGROUND: Testing for KRAS mutations in metastatic colorectal cancer (mCRC) on formalin-fixed, paraffin embedded (FFPE) tumor tissue has become standard of care.	Paraffin	97-105	KRAS proto-oncogene, GTPase	Homo sapiens	24-28
28030838-3	2017	Livin protein expression was assessed by immunohistochemistry in 270 paraffin-embedded tissues (192 ACC, 58 ACA, 20 NAG).	Paraffin	69-77	baculoviral IAP repeat containing 7	Homo sapiens	0-5
29199691-6	2017	Detection of ALK fusion was done by IHC on formalin fixed paraffin embedded cell blocks.	Paraffin	58-66	ALK receptor tyrosine kinase	Homo sapiens	13-16
28155154-2	2017	As a stress response mechanism, it may also be involved in cellular response to therapy.LC3 and Sequestosome 1 (p62/SQSTM1) are among the most widely used markers to monitor autophagy, and can be visualized in formalin-fixed and paraffin-embedded tissue by immunohistochemistry.	Paraffin	229-237	sequestosome 1	Homo sapiens	96-110
28155154-2	2017	As a stress response mechanism, it may also be involved in cellular response to therapy.LC3 and Sequestosome 1 (p62/SQSTM1) are among the most widely used markers to monitor autophagy, and can be visualized in formalin-fixed and paraffin-embedded tissue by immunohistochemistry.	Paraffin	229-237	sequestosome 1	Homo sapiens	112-115
28155154-2	2017	As a stress response mechanism, it may also be involved in cellular response to therapy.LC3 and Sequestosome 1 (p62/SQSTM1) are among the most widely used markers to monitor autophagy, and can be visualized in formalin-fixed and paraffin-embedded tissue by immunohistochemistry.	Paraffin	229-237	sequestosome 1	Homo sapiens	116-122
28043154-3	2017	Immunohistochemical detection of AIF expression in formalin fixed and in paraffin embedded tissue samples was evaluated semiquantitatively, intensity and percentage multiplicative Quick Score (QS) was calculated and compared between patients with over 5 year (n=32) and less than 5 year (n=22) survival.	Paraffin	73-81	apoptosis inducing factor mitochondria associated 1	Homo sapiens	33-36
27907908-4	2016	BRCA1/2 mutations were identified using next-generation sequencing of formalin-fixed paraffin-embedded tumor samples.	Paraffin	85-93	BRCA1 DNA repair associated	Homo sapiens	0-7
28105226-12	2016	The expression of EGFL7 and Snail was examined in paraffin-embedded tissue sample sections using the avidin-biotin peroxidase complex method.	Paraffin	50-58	EGF like domain multiple 7	Homo sapiens	18-23
27760890-6	2016	Molecular studies with formalin-fixed, paraffin-embedded tissues were performed in search of a partial region of the cytochrome b gene for hemosporidian parasites.	Paraffin	39-47	CYTB	Gallus gallus	117-129
27159521-9	2016	Immunohistochemical staining of paraffin-embedded skin sections showed enrichment of IFI-16 in CD31-positive vascular endothelial cells in biopsy specimens from scleroderma patients and normal controls.	Paraffin	32-40	interferon gamma inducible protein 16	Homo sapiens	85-91
27698842-3	2016	Furthermore, the present study investigated the protein expression and the clinicopathological significance of TIG2 in 98 paraffin-embedded NSCLC samples by using immunohistochemistry.	Paraffin	122-130	retinoic acid receptor responder 2	Homo sapiens	111-115
27632281-5	2016	KRAS multiplex mutation analysis usefulness was also demonstrated with formalin-fixed paraffin embedded (FFPE) from CRC biopsies.	Paraffin	86-94	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
27514839-1	2016	Increased demand for BRCA testing is placing pressures on diagnostic laboratories to raise their mutation screening capacity and handle the challenges associated with classifying BRCA sequence variants for clinical significance, for example interpretation of pathogenic mutations or variants of unknown significance, accurate determination of large genomic rearrangements and detection of somatic mutations in DNA extracted from formalin-fixed, paraffin-embedded tumour samples.	Paraffin	445-453	BRCA1 DNA repair associated	Homo sapiens	21-25
27240592-8	2016	Finally, BCL6 and Lewis Y antigen were validated at the protein level by immunohistochemistry in 103 paraffin-embedded ovarian cancer tissues.	Paraffin	101-109	BCL6 transcription repressor	Homo sapiens	9-13
27579449-5	2016	The presence of IgA1 was confirmed in formalin-fixed paraffin-embedded ovarian carcinoma samples using LC-MS/MS analysis.	Paraffin	53-61	immunoglobulin heavy constant alpha 1	Homo sapiens	16-20
27446412-5	2016	FOXL2 mutational status was evaluated using a pyrosequencing approach on 2.5-microm sections of formalin-fixed paraffin-embedded tissue.	Paraffin	111-119	forkhead box L2	Homo sapiens	0-5
1373018-1	1992	We have developed monoclonal antibodies that detect normal microtubule-associated protein-2 (MAP2) epitopes in routinely fixed, paraffin-embedded tissue.	Paraffin	128-136	microtubule associated protein 2	Homo sapiens	93-97
1357815-2	1992	We have previously reported on a monoclonal antibody, TJ4C4, which is able to specifically detect p68 in formalin-fixed, paraffin-embedded tissue.	Paraffin	121-129	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	98-101
2064275-1	1991	Forty-two cases of squamous cell carcinoma arising in the upper aerodigestive tract were examined to determine the incidence and type of point mutation in codon 12 of the c-K-ras gene by using the polymerase chain reaction and oligonucleotide hybridization techniques on DNA extracted from paraffin blocks.	Paraffin	290-298	KRAS proto-oncogene, GTPase	Homo sapiens	171-178
18667776-2	2008	METHODS: EnVision immunohistochemical method was used to detect the expressive levels of EZH2 and PTEN in routinely paraffin-embedded sections in the resected specimens of gallbladder adenocarcinoma (n = 108), peritumoral tissues (n = 46), adenomatous polyp(n = 15), and chronic cholecystitis (n = 35).	Paraffin	116-124	phosphatase and tensin homolog	Homo sapiens	98-102
2049776-1	1991	Point mutation in codons 12, 13 and 61 of the K-ras oncogene in gastric epithelial tumors were investigated by polymerase chain reaction from sections of formalin-fixed, paraffin-embedded tissue followed by dot-blot hybridization with mutation-specific oligonucleotide probes.	Paraffin	170-178	KRAS proto-oncogene, GTPase	Homo sapiens	46-51
1989458-7	1991	An immunohistochemical study for prostatic acid phosphatase and prostatic-specific antigen could be carried out on paraffin blocks from 19 biopsies and 18 prostatectomies.	Paraffin	115-123	acid phosphatase 3	Homo sapiens	33-59
27223112-3	2016	AIMS: The present study was designed to assess the immunohistochemical expression of the ST2 receptor (ST2L/Il-1R) in atherosclerotic plaques of formalin fixed paraffin-embedded internal carotid arteries of patients with and without cerebro-vascular symptoms.	Paraffin	160-168	ST2	Homo sapiens	89-92
27099512-4	2016	METHODS: Immunohistochemistry was performed to examine the subcellular localization and the expression level of ZEB1 protein in 82 self-pairs of formalin-fixed and paraffin-embedded cancerous and adjacent noncancerous tissues obtained from patients with thyroid cancer.	Paraffin	164-172	zinc finger E-box binding homeobox 1	Homo sapiens	112-116
18589866-1	2008	CD45R/B220 antigen (B220) is a common mouse panB-cell marker used for paraffin-embedded tissues.	Paraffin	70-78	protein tyrosine phosphatase, receptor type, C	Mus musculus	6-10
26956379-5	2016	In addition, FGF23 mRNA expression was detected by reverse transcription-polymerase chain reaction (RT-PCR), using RNA extracted from formalin-fixed, paraffin-embedded tissues.	Paraffin	150-158	fibroblast growth factor 23	Homo sapiens	13-18
1793484-5	1991	Amplification of Ki-ras sequences from formalin-fixed, paraffin-embedded tissue by the polymerase chain reaction was followed by direct DNA sequencing.	Paraffin	55-63	KRAS proto-oncogene, GTPase	Rattus norvegicus	17-23
1711732-1	1991	The expression of keratins 8 and 14 was investigated immunohistochemically by the avidin-biotin-peroxidase (ABC) method using formalin-fixed paraffin-embedded specimens from 42 tumours of human skin appendages.	Paraffin	141-149	keratin 8	Homo sapiens	18-35
18589866-1	2008	CD45R/B220 antigen (B220) is a common mouse panB-cell marker used for paraffin-embedded tissues.	Paraffin	70-78	protein tyrosine phosphatase, receptor type, C	Mus musculus	20-24
18462056-15	2008	Immunohistochemistry on paraffin-embedded sections of intact ex vivo-expanded limbal epithelium for the putative positive marker p63 and cytokeratin K3 confirmed the findings of the quantitative RT-PCR and CFE results.	Paraffin	24-32	tumor protein p63	Homo sapiens	129-132
2250189-1	1990	An avidin-biotin enhanced immunoperoxidase procedure using monoclonal antibodies (AA1, AA3, and AA5) prepared against human mast cell tryptase resulted in intense staining of mast cells in paraffin-embedded tissue.	Paraffin	189-197	aspartoacylase (aminoacylase) 3	Mus musculus	87-90
2250189-1	1990	An avidin-biotin enhanced immunoperoxidase procedure using monoclonal antibodies (AA1, AA3, and AA5) prepared against human mast cell tryptase resulted in intense staining of mast cells in paraffin-embedded tissue.	Paraffin	189-197	tryptase delta 1	Homo sapiens	124-142
2158242-9	1990	On paraffin sections, the Ki-1--related antibody Ber-H2 provided excellent staining results in all cases.	Paraffin	3-11	TNF receptor superfamily member 8	Homo sapiens	26-30
26553251-4	2016	METHODS: In this study, the expression of Cdc5L was evaluated by Western blot in 8 paired fresh HCC tissues and immunohistochemistry on 116 paraffin-embedded slices.	Paraffin	140-148	cell division cycle 5 like	Homo sapiens	42-47
33768318-3	2021	In this study, we aim to validate the diagnostic performance of multiplex BCL2/BCL6 FISH approach in formalin-fixed paraffin-embedded FLs and DBCLs and cytological samples of DLBCL comparing to the classic set of single break-apart probes.	Paraffin	116-124	BCL6 transcription repressor	Homo sapiens	79-83
18311114-5	2008	Immunohistochemistry was used to evaluate p63 expression in paraffin embedded sections of giant cell tumor of bone and in tumors containing multinucleated giant cells, including: giant cell tumor of tendon sheath, pigmented villonodular synovitis, aneurysmal bone cyst, chondroblastoma, and central giant cell granuloma.	Paraffin	60-68	tumor protein p63	Homo sapiens	42-45
34810101-7	2022	Consequently, the findings of this study highlighted the rapid diagnosis of gastric and colon cancer cases from paraffin-embedded tissues via ATR-MIR spectroscopy complemented with chemometrics.	Paraffin	112-120	membrane associated ring-CH-type finger 8	Homo sapiens	146-149
34732853-3	2022	RAD51 foci were quantified in formalin-fixed, paraffin-embedded untreated tumour specimens by immunofluorescence and the messenger RNA expression of 21 DNA repair genes by real-time PCR.	Paraffin	46-54	RAD51 recombinase	Homo sapiens	0-5
25943321-3	2016	MATERIALS AND METHODS: Pyrosequencing was used to identify KRAS mutation and hypermethylation of 6 CpG island loci (p16, p14, MINT1, MINT2, MINT31, and hMLH1) in DNA extracted from formalin-fixed paraffin-embedded specimens.	Paraffin	196-204	KRAS proto-oncogene, GTPase	Homo sapiens	59-63
17587322-2	2008	TLR5 expression was evaluated by immunohistochemistry (IHC) in 55 formalin-fixed paraffin-embedded cervical tissues; 10 normal cervical specimens, 9 low-grade cervical intraepithelial neoplasias (CINs), 12 high-grade CINs, and 24 invasive squamous cell carcinomas (ISCCs).	Paraffin	81-89	toll like receptor 5	Homo sapiens	0-4
26316588-3	2015	In this study, we found that the high level of RAGE expression in 29 pairs of paraffin-embedded ESCC tissues was correlated positively with the depth of invasion by immunohistochemistry, suggesting that RAGE was involved in ESCC.	Paraffin	78-86	long intergenic non-protein coding RNA 914	Homo sapiens	47-51
26316588-3	2015	In this study, we found that the high level of RAGE expression in 29 pairs of paraffin-embedded ESCC tissues was correlated positively with the depth of invasion by immunohistochemistry, suggesting that RAGE was involved in ESCC.	Paraffin	78-86	long intergenic non-protein coding RNA 914	Homo sapiens	203-207
34923792-7	2021	Immunohistochemical staining was used to count the CD8+ T cells in tumor center and invasive margin in the paraffin slides.	Paraffin	107-115	CD8a molecule	Homo sapiens	51-54
18245548-2	2008	EXPERIMENTAL DESIGN: Hsp90 expression was determined by immunohistochemistry in 44 paraffin-embedded sections of primary human uveal melanoma and in five uveal melanoma cell lines (92.1, OCM-1, MKT-BR, SP6.5, and UW-1).	Paraffin	83-91	heat shock protein 90 alpha family class A member 1	Homo sapiens	21-26
26519197-1	2015	BACKGROUND: The role of methylation status of the thyroid stimulating hormone receptor gene (TSHr) in the discrimination of benign and malignant thyroid nodules has already been studied using paraffin blocks and cell lines.	Paraffin	192-200	thyroid stimulating hormone receptor	Homo sapiens	93-97
34956870-5	2021	CD146 expression in paraffin-embedded tissues (140 cancer samples and 140 paracancer tissues) from our cohort were examined by immunohistochemistry assay.	Paraffin	20-28	melanoma cell adhesion molecule	Homo sapiens	0-5
18245548-6	2008	RESULTS: Immunohistochemical expression of Hsp90 was identified in 68% of the paraffin-embedded sections and significantly associated with largest tumor dimension (P = 0.03).	Paraffin	78-86	heat shock protein 90 alpha family class A member 1	Homo sapiens	43-48
18026163-1	2008	Hepatocyte paraffin 1 (Hep Par 1), a murine monoclonal antibody, is widely used in surgical pathology practice to determine the hepatocellular origin of neoplasms.	Paraffin	11-19	Prader Willi/Angelman region RNA 1	Homo sapiens	27-32
26117383-11	2015	We conclude that MDR3 immunostaining on formalin-fixed and paraffin-embedded sections is a useful tool to diagnose severe MDR3 deficiency in pediatric liver cholestatic disease cases where genetic testing is not available.	Paraffin	59-67	ATP binding cassette subfamily B member 4	Homo sapiens	17-21
17318378-5	2007	In 99.3% of the malignant lesions preceding CNB was correctly classified as B5 (n = 1185, 92.9%) or at least B4 (n = 82, 6.4%) in frozen and in paraffin sections.	Paraffin	144-152	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	44-47
34842456-2	2022	Methods: SNORD83A was selected based on databases and further verified in 48 paired formalin-fixed, paraffin-embedded tissues, as well as in plasma from 150 NSCLC patients and 150 healthy donors.	Paraffin	100-108	small nucleolar RNA, C/D box 83A	Homo sapiens	9-17
34388694-5	2021	FAM60A protein expression in 179 archived, paraffin-embedded glioma samples was analyzed using immunohistochemistry.	Paraffin	43-51	SIN3-HDAC complex associated factor	Homo sapiens	0-6
26722540-3	2015	FRZB expression was evaluated by immunohistochemistry in formalin-fixed paraffin embedded (FFPE) HCC and paired bone metastasis tissues from 13 patients that underwent surgical resection.	Paraffin	72-80	frizzled related protein	Homo sapiens	0-4
17318378-6	2007	There were seven false-negative cases in frozen (false-negative rate = 0.5%) and five false-negative cases (false-negative rate = 0.4%) in paraffin sections of CNB.	Paraffin	139-147	protein phosphatase 3 regulatory subunit B, alpha	Homo sapiens	160-163
18085999-4	2007	GSTP1 and ERCC2 genotypes were identified on DNA samples extracted from paraffin blocks containing either normal tissue (nodes) or tumor tissue.	Paraffin	72-80	glutathione S-transferase pi 1	Homo sapiens	0-5
26464681-3	2015	Moreover, PBRM1 protein expression was evaluated by immunohistochemistry in 150 paraffin-embedded breast cancer specimens.	Paraffin	80-88	polybromo 1	Homo sapiens	10-15
34526111-10	2021	Col11a1a within formalin-fixed paraffin-embedded zebrafish were recognized by the antibody.	Paraffin	31-39	collagen, type XI, alpha 1a	Danio rerio	0-8
18085999-4	2007	GSTP1 and ERCC2 genotypes were identified on DNA samples extracted from paraffin blocks containing either normal tissue (nodes) or tumor tissue.	Paraffin	72-80	ERCC excision repair 2, TFIIH core complex helicase subunit	Homo sapiens	10-15
17979543-3	2007	In spite of its importance in the diagnosis and treatment of cancer, monoclonal antibodies to FR-alpha suitable for immunohistochemical analysis of formalin-fixed and paraffin-embedded biopsy samples, or that can be used for Western blot analysis, are not available.	Paraffin	167-175	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	94-102
34392674-4	2021	Due to the protective effect of SiO2, PDA layer, and SR matrix, the SR/Pa@SiO2@PDA composites have good leak-proofing performance, and the leakage rate of SR/Pa@SiO2@PDA-2 is as low as 0.45%.	Paraffin	158-160	transcription factor AP-2 beta	Homo sapiens	166-171
34392674-7	2021	The tensile strength of SR/Pa@SiO2@PDA-2 can be up to 0.560 MPa, which is 1.85 times higher than the tensile strength of pure SR/Pa@SiO2 because the interface compatibility between Pa@SiO2 microcapsules and SR is improved through hydrogen bonding between the abundant groups on the PDA surface and the matrix.	Paraffin	27-29	transcription factor AP-2 beta	Homo sapiens	35-40
34168109-3	2021	The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.	Paraffin	53-61	actin filament associated protein 1	Homo sapiens	4-9
34092577-5	2021	METHODS: The immunohistochemical staining technique was used to show the expression of FBP1 and LDHB in formalin-fixed, paraffin-embedded blocks of 32 fibroadenomas and 31 invasive breast cancer samples.	Paraffin	120-128	fructose-bisphosphatase 1	Homo sapiens	87-91
26703339-12	2015	Screening ALK fusion protein expression in patients with lung adenocarcinoma by paraffin-embedded sediments of pleural effusion was useful in guide of crizotinib therapy.	Paraffin	80-88	ALK receptor tyrosine kinase	Homo sapiens	10-13
17979543-4	2007	The aim of this study was thus to generate a monoclonal antibody that could be used to detect specific expression of FR-alpha in paraffin-embedded tissues.	Paraffin	129-137	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	117-125
17979543-10	2007	Our results show that clone BN3.2 is a sensitive tool for detection of FR-alpha in paraffin-embedded tissues.	Paraffin	83-91	rabaptin, RAB GTPase binding effector protein 2	Homo sapiens	71-79
17683460-5	2007	The cellular expression of TNP1 mRNA in spermatids was quantified by in situ hybridisation on paraffin sections of testis biopsies from 21 men with obstructive azoospermia and 23 men with non-obstructive azoospermia.	Paraffin	94-102	transition protein 1	Homo sapiens	27-31
26416063-3	2015	The purpose of the current study was to detect the expression of MRGD mRNA in NSCLC formalin-fixed (FF), paraffin-embedded (PE) tissues and to investigate the clinicopathological significance of the MRGD level in NSCLC patients.	Paraffin	105-113	MAS related GPR family member D	Homo sapiens	65-69
35528164-6	2022	The expression of SCD1 in 491 formalin-fixed, paraffin-embedded CRC specimens was investigated with immunochemistry.	Paraffin	46-54	stearoyl-Coenzyme A desaturase 1	Mus musculus	18-22
17576433-4	2007	In the present study, we analyzed expression of GalNAc4S-6ST mRNA in colorectal cancer by combining real-time RT-PCR with in situ hybridization (ISH) using archived formalin-fixed and paraffin-embedded tissue sections.	Paraffin	184-192	carbohydrate sulfotransferase 15	Homo sapiens	48-60
35048461-0	2022	Clinicopathological significance of CBX3 in colorectal cancer: An intensive expression study based on formalin-fixed and paraffin-embedded tissues.	Paraffin	121-129	chromobox 3	Rattus norvegicus	36-40
35048461-3	2022	In this study, we examined CBX3 protein expression in formalin-fixed and paraffin-embedded normal mucosae, hyperplastic polyps, low-and high-grade adenomas, and CRC tissue samples using immunohistochemistry.	Paraffin	73-81	chromobox 3	Rattus norvegicus	27-31
25666753-4	2015	CD68(+) TAMs were identified in paraffin-embedded OSCC specimens (n = 91) by using immunohistochemistry.	Paraffin	32-40	CD68 molecule	Homo sapiens	0-4
35096084-5	2022	The STC2 immunohistochemical expression was detected and evaluated in 60 cases of colorectal cancer tissue samples of formalin-fixed and paraffin-embedded blocks.	Paraffin	137-145	stanniocalcin 2	Homo sapiens	4-8
17576433-8	2007	Taken together, we show that real-time RT-PCR combined with ISH is useful to investigate quantitatively GalNAc4S-6ST mRNA expression in formalin-fixed and paraffin-embedded tissue sections, and that GalNAc4S-6ST expressed by colorectal cancer cells plays a minor role in tumor progression.	Paraffin	155-163	carbohydrate sulfotransferase 15	Homo sapiens	104-116
17417681-3	2007	The HBx gene was examined in 51 paraffin-embedded tumor tissue samples from patients with HCC and 25 serum samples from the HBV carrier by nested polymerase chain reaction (PCR), single-stranded conformational polymorphism and heteroduplex analysis.	Paraffin	32-40	X protein	Hepatitis B virus	4-7
25820371-6	2015	The PLA2R1 positivity rate for the paraffin-embedded sections was 61%, whereas that for the frozen sections was 65%.	Paraffin	35-43	phospholipase A2 receptor 1	Homo sapiens	4-10
25820371-8	2015	Discrepancies between different sample preparations occurred in three cases (6%); two cases were PLA2R1-positive in paraffin sections and PLA2R1-negative in frozen sections and one case was PLA2R1-negative in paraffin sections and PLA2R1-positive in frozen sections.	Paraffin	116-124	phospholipase A2 receptor 1	Homo sapiens	97-103
17319000-3	2007	We studied by immunohistochemistry the distribution pattern of uPAR on 173 paraffin-embedded samples of invasive breast carcinomas in relation to clinicopathologic data and patients" survival.	Paraffin	75-83	plasminogen activator, urokinase receptor	Homo sapiens	63-67
25801334-5	2015	Immunohistochemistry was used to analyze clinicopathological patterns of FBX8 in 136 cases of clinical paraffin-embedded GC tissues.	Paraffin	103-111	F-box protein 8	Homo sapiens	73-77
26221340-4	2015	Paraffin archived samples from 83 GA patients were used to analyze ACLY expression by immunohistochemistry.	Paraffin	0-8	ATP citrate lyase	Homo sapiens	67-71
26150155-0	2015	Reliable LC3 and p62 autophagy marker detection in formalin fixed paraffin embedded human tissue by immunohistochemistry.	Paraffin	66-74	sequestosome 1	Homo sapiens	17-20
26150155-3	2015	Here we show the feasibility of specifically and reliably assessing the autophagy markers LC3B and p62 (SQSTM1) in formalin fixed and paraffin embedded human tissue by immunohistochemistry.	Paraffin	134-142	sequestosome 1	Homo sapiens	104-110
26150155-11	2015	In summary, we present a specific and reliable IHC staining of LC3B and p62 on formalin fixed and paraffin embedded human tissue.	Paraffin	98-106	sequestosome 1	Homo sapiens	72-75
17223852-6	2007	MYCN status was determined by fluorescent in situ hybridization (FISH) on paraffin sections from the primary tumour.	Paraffin	74-82	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	0-4
25659223-2	2015	OBJECTIVE: We aimed to assess the diagnostic accuracy of an immunohistochemistry (IHC) approach using a novel anti-NRAS (Q61R) monoclonal antibody on formalin-fixed paraffin-embedded tissue samples from patients with metastatic melanoma.	Paraffin	165-173	NRAS proto-oncogene, GTPase	Homo sapiens	115-119
16538493-4	2007	METHODS: TS expression from 131 patients with ductal adenocarcinoma of the pancreas was analyzed by immunohistochemistry in paraffin-embedded primary tumour specimens or biopsies.	Paraffin	124-132	thymidylate synthetase	Homo sapiens	9-11
25925371-3	2015	METHODS: We employed quantitative real-time polymerase chain reaction (qPCR) to determine the expression of JWA, XRCC1 and BRCA1 mRNA in paraffin-embedded specimen from 172 patients with advanced ESCC who underwent the first-line cisplatin-or docetaxel-based treatments.	Paraffin	137-145	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	108-111
25925371-3	2015	METHODS: We employed quantitative real-time polymerase chain reaction (qPCR) to determine the expression of JWA, XRCC1 and BRCA1 mRNA in paraffin-embedded specimen from 172 patients with advanced ESCC who underwent the first-line cisplatin-or docetaxel-based treatments.	Paraffin	137-145	BRCA1 DNA repair associated	Homo sapiens	123-128
24748501-5	2015	METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested methylation-specific PCR in 102 paraffin-embedded gastric cancer samples.	Paraffin	158-166	FA complementation group F	Homo sapiens	71-76
24748501-5	2015	METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested methylation-specific PCR in 102 paraffin-embedded gastric cancer samples.	Paraffin	158-166	O-6-methylguanine-DNA methyltransferase	Homo sapiens	78-82
24748501-5	2015	METHODS: The methylation status of five DNA damage repair genes (CHFR, FANCF, MGMT, MLH1, and RASSF1A) was detected by nested methylation-specific PCR in 102 paraffin-embedded gastric cancer samples.	Paraffin	158-166	Ras association domain family member 1	Homo sapiens	94-101
16878328-7	2006	RESULTS: EWS-ATF1 fusion transcripts were detected in 38 paraffin embedded CCS tissues (86% of all samples; 93% of interpretable samples), 3 samples (7%) were negative, and 3 samples (7%) were considered uninterpretable.	Paraffin	57-65	activating transcription factor 1	Homo sapiens	9-17
25527510-4	2015	Expression and translocation of the ALK gene were analyzed by immunohistochemistry (IHC), fluorescence in situ hybridization (FISH), and digital multiplexed gene expression (DMGE) analysis in formalin-fixed paraffin-embedded tissues.	Paraffin	207-215	ALK receptor tyrosine kinase	Homo sapiens	36-39
16878328-13	2006	CONCLUSIONS: The results of this study showed that the molecular detection of EWS-ATF1 fusion transcript by real-time PCR on paraffin embedded tissues is a sensitive and specific method for the diagnosis of CCS.	Paraffin	125-133	activating transcription factor 1	Homo sapiens	78-86
24917463-0	2015	MicroRNA expression signatures for the prediction of BRCA1/2 mutation-associated hereditary breast cancer in paraffin-embedded formalin-fixed breast tumors.	Paraffin	109-117	BRCA1 DNA repair associated	Homo sapiens	53-60
17037611-4	2006	We describe application of a DNA extraction procedure for formalin-fixed, paraffin-embedded tissues (PET) for the purpose of PCR amplification and nucleotide sequencing of relevant codons (136-171) of the sheep PrP gene.	Paraffin	74-82	major prion protein	Ovis aries	211-214
25973069-3	2015	We quantified promoter methylation of MGMT using pyrosequencing on paraffin-embedded fine needle aspiration biopsy tissues from 43 glioblastoma.	Paraffin	67-75	O-6-methylguanine-DNA methyltransferase	Homo sapiens	38-42
25025444-12	2015	We conclude that RNAscope is a highly sensitive and specific, semiquantitative in situ hybridization method of FGF23 mRNA detection applicable to formalin-fixed, paraffin-embedded tissues.	Paraffin	162-170	fibroblast growth factor 23	Homo sapiens	111-116
25049152-9	2006	The fluorescence intensity obtained from paraffin sections of excised gastric cancer tissues revealed a tendency to be greater with ICG-ATT-labeled Fab than with ICG-ATT-labeled IgG.	Paraffin	41-49	FA complementation group B	Homo sapiens	148-151
26514456-2	2015	MATERIALS AND METHODS: FASN expression was assessed in gastric cancers by immunohistochemistry using 60 paraffin-embedded tissue specimens, and clinical data were collected by retrospective chart review.	Paraffin	104-112	fatty acid synthase	Homo sapiens	23-27
16750322-3	2006	The expression of EGFr was assessed on paraffin-embedded tissue of the primary tumor by immunohistochemistry using a monoclonal antibody directed against EGFr.	Paraffin	39-47	epidermal growth factor	Homo sapiens	18-22
25755786-5	2015	In paraffin-embedded cervical cancer samples, high expression of ROR2 was shown in 40 (42.6%) of 94 cases, also, it was significantly associated with tumor stage (P = 0.018) and lymph nodes metastasis (P = 0.013).	Paraffin	3-11	receptor tyrosine kinase like orphan receptor 2	Homo sapiens	65-69
16461563-5	2006	METHODS: The pattern of PPH3 staining in formalin-fixed paraffin wax-embedded tissues, including normal tissues and a series of 39 breast adenocarcinomas, was examined.	Paraffin	56-68	protein phosphatase 4 catalytic subunit	Homo sapiens	24-28
25310193-11	2015	In paraffin sections, a positive correlation between the Ki-67 antigen and nuclear SOX18 expression (r=0.17, p&lt;0.05) was noted.	Paraffin	3-11	SRY-box transcription factor 18	Homo sapiens	83-88
26191531-8	2015	Dual label immunohistochemistry on formalin-fixed paraffin-embedded tumor tissue revealed reduced expression of tropoelastin in LANA positive spindle cell regions quantified by Ariol SL-50 scanning analysis.	Paraffin	50-58	elastin	Homo sapiens	112-124
25259564-4	2014	METHODS: In this study, the authors investigated MMP2 and TIMP2 gene polymorphisms in formalin-fixed paraffin-embedded tissue samples obtained from meningioma patients who had previously undergone surgery at the authors" institution.	Paraffin	101-109	TIMP metallopeptidase inhibitor 2	Homo sapiens	58-63
16699319-4	2006	We have used a chromogenic method for in situ hybridization (CISH) that enables determination of MYCN copy number using routine light microscopy on routinely processed paraffin sections.	Paraffin	168-176	cytokine inducible SH2 containing protein	Homo sapiens	61-65
24930116-4	2014	METHODS: This report describes studies of the distribution of genotypes and the frequency of alleles of the G135C (rs1801320) and G172T (rs1801321) RAD51 polymorphism in 630 paraffin-embedded samples of tumor tissue from patients with endometrial cancer.	Paraffin	174-182	RAD51 recombinase	Homo sapiens	148-153
25119597-6	2014	Immunohistochemical expression of Tim-3 was examined in our large numbers of paraffin-fixed prostate tissues.	Paraffin	77-85	hepatitis A virus cellular receptor 2	Homo sapiens	34-39
16699319-4	2006	We have used a chromogenic method for in situ hybridization (CISH) that enables determination of MYCN copy number using routine light microscopy on routinely processed paraffin sections.	Paraffin	168-176	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	97-101
25142627-4	2014	Immunohistochemical staining for EGFL7 was performed using tissue microarrays made with paraffin-embedded tissue block.	Paraffin	88-96	EGF like domain multiple 7	Homo sapiens	33-38
16703752-3	2006	MATERIALS AND METHODS: In the present study, Taqman SNP genotyping assay was used to detect PAI-1 4G/5G polymorphism in DNA from paraffin-embedded tissues of 98 Caucasian patients with prostate cancer.	Paraffin	129-137	serpin family E member 1	Homo sapiens	92-97
24717977-8	2014	Immunohistochemical studies and in situ hybridization of formalin fixed and paraffin embedded sections of human late term placenta showed expression of SOAT in syncytiotrophoblasts, predominantly at the apical membrane as well as in the vessel endothelium.	Paraffin	76-84	solute carrier family 10 member 6	Homo sapiens	152-156
16648762-4	2006	STUDY DESIGN: The expression of beta-catenin (BD Transduction Laboratories) was analyzed by immunohistochemistry in formalin-fixed, paraffin embedded specimens by the avidin-biotin-peroxidase complex method in 16 pleomorphic adenomas (12 from minor salivary glands), 3 carcinomas in pleomorphic adenomas (all from palate) and 10 normal salivary glands as control group (5 from major and 5 from minor salivary glands).	Paraffin	132-140	catenin beta 1	Homo sapiens	32-44
25059753-4	2014	Additionally, RCDG1 expression was assessed in 124 RCC paraffin sections, including 92 paired adjacent normal tissues, by immunohistochemistry.	Paraffin	55-63	chromosome 4 open reading frame 46	Homo sapiens	14-19
16540728-6	2006	At the RNA level TS mRNA expression was measured on formalin-fixed paraffin-embedded tumor tissue and on fresh-frozen tumor tissue by real-time RT-PCR.	Paraffin	67-75	thymidylate synthetase	Homo sapiens	17-19
25337229-4	2014	The expression level of HDAC10 in 179 paraffin-embedded gastric cancer tissue specimens was examined by immunohistochemistry (IHC).	Paraffin	38-46	histone deacetylase 10	Homo sapiens	24-30
25337249-4	2014	The protein expression of LOX was measured by immunohistochemistry (IHC) in 110 paraffin-embedded tissues with NSCLC and the protein expression of MMP2/MMP9 was measured by in 30 NSCLC patients.	Paraffin	80-88	lysyl oxidase	Homo sapiens	26-29
24709436-4	2014	MGMT methylation status was assessed in formalin-fixed, paraffin-embedded tumor specimens by pyrosequencing.	Paraffin	56-64	O-6-methylguanine-DNA methyltransferase	Homo sapiens	0-4
16540728-8	2006	Correlation was found between TS mRNA expression in fresh-frozen tumor tissue and formalin-fixed paraffin-embedded tissue (R=0.71).	Paraffin	97-105	thymidylate synthetase	Homo sapiens	30-32
16520839-4	2006	METHODS: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections.	Paraffin	170-178	serpin family B member 3	Homo sapiens	108-111
16426442-3	2006	METHODS: Expression of PTTG-1 was examined immunohistochemically on formalin-fixed, paraffin-embedded tissue sections of 136 patients with small cell lung cancer (SCLC) and 91 patients with non-small cell lung cancer (NSCLC), retrospectively.	Paraffin	84-92	PTTG1 regulator of sister chromatid separation, securin	Homo sapiens	23-29
24531749-4	2014	TBX2 expression was evaluated by qRT-PCR and Western blotting in 50 paired fresh lung cancer tissues as well as immunohistochemistry on 212 paraffin-embedded sections.	Paraffin	140-148	T-box transcription factor 2	Homo sapiens	0-4
16353391-3	2005	MATERIAL AND METHODS: Qualitative immunohistochemical studies were performed by using specific antibodies to VEGF and its receptors on paraffin sections of the cochlea.	Paraffin	135-143	vascular endothelial growth factor A	Rattus norvegicus	109-113
24664550-0	2014	Highly sensitive KRAS mutation detection from formalin-fixed paraffin-embedded biopsies and circulating tumour cells using wild-type blocking polymerase chain reaction and Sanger sequencing.	Paraffin	61-69	KRAS proto-oncogene, GTPase	Homo sapiens	17-21
24664550-9	2014	CONCLUSION: Our results present a simple, effective, and robust method for KRAS mutation detection in both paraffin embedded tissues and circulating tumour cells, at single-cell level.	Paraffin	107-115	KRAS proto-oncogene, GTPase	Homo sapiens	75-79
16293180-0	2005	hTERT expression in melanocytic lesions: an immunohistochemical study on paraffin-embedded tissue.	Paraffin	73-81	telomerase reverse transcriptase	Homo sapiens	0-5
24912585-6	2014	Immunohistochemical analysis revealed that Tiam1 had high expression in 96 of 140 (68.6%) paraffin-embedded archival NPC biopsies.	Paraffin	90-98	TIAM Rac1 associated GEF 1	Homo sapiens	43-48
25025378-4	2014	XRCC1 Arg399Glu and ERCC1 Cys8092Ala SNPs were identified from paraffin-embedded biopsy specimens via Sanger sequencing.	Paraffin	63-71	X-ray repair cross complementing 1	Homo sapiens	0-5
16293180-3	2005	The aim of this study was to evaluate human telomerase reverse transcriptase (hTERT) staining in melanocytic lesions on paraffin-embedded tissues.	Paraffin	120-128	telomerase reverse transcriptase	Homo sapiens	44-76
16293180-3	2005	The aim of this study was to evaluate human telomerase reverse transcriptase (hTERT) staining in melanocytic lesions on paraffin-embedded tissues.	Paraffin	120-128	telomerase reverse transcriptase	Homo sapiens	78-83
24947617-2	2014	METHODS: KLF17 expressions in 158 paraffin-embedded gastric cancer samples were analyzed using immunohistochemistry.	Paraffin	34-42	Kruppel like factor 17	Homo sapiens	9-14
16189152-2	2005	METHODS: Non-radioactive in situ hybridisation for H19 RNA was performed on paraffin wax embedded sections of liver biopsies or partial hepatectomy specimens, taken from 80 patients with hepatic metastases derived from carcinomas from several medical centres in Israel.	Paraffin	76-88	H19 imprinted maternally expressed transcript	Homo sapiens	51-54
24559182-4	2014	METHODS: The expression of alpha2a and beta2 AR was examined in paraffin-embedded samples of 220 operable breast tumors by immunohistochemistry.	Paraffin	64-72	adrenoceptor beta 2	Homo sapiens	39-47
16210136-6	2005	The HO-1 genotype was assessed using genomic DNA isolated from paraffin-embedded allograft biopsy specimens.	Paraffin	63-71	heme oxygenase 1	Homo sapiens	4-8
16106200-13	2005	As the assay does not require reference tissue, can be performed with small amounts of DNA, and allows the investigation of paraffin-embedded material for the MYCN-status, it can be regarded alternative to LOH or SB analyses and in addition to FISH.	Paraffin	124-132	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	159-163
23773367-4	2014	METHODS: We performed conventional immunohistochemistry of LC3 in paraffin-embedded human livers with different severities of steatosis, obtained at autopsy.	Paraffin	66-74	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	59-62
24913813-6	2014	ITIH5 expression was retrospectively detected in 331 paraffin-embedded, banked samples using immunohistochemical staining.	Paraffin	53-61	inter-alpha-trypsin inhibitor heavy chain 5	Homo sapiens	0-5
16244583-4	2005	PATIENTS AND METHODS: We examined the relationship between galectin-3 and cell proliferation by comparative immunostaining for galectin-3 and proliferating cell nuclear antigen (PCNA) in paraffin-embedded tissues from 126 cases of papillary thyroid carcinoma.	Paraffin	187-195	proliferating cell nuclear antigen	Homo sapiens	178-182
16077970-3	2005	TS expression was determined immunohistochemically in 86 paraffin-embedded primary tumour sections and assessed using image analysis software.	Paraffin	57-65	thymidylate synthetase	Homo sapiens	0-2
24767895-3	2014	We evaluated livin expression in 38 CHL, 23 NHL, and 39 nonneoplastic lymph nodes in paraffin-embedded blocks.	Paraffin	85-93	baculoviral IAP repeat containing 7	Homo sapiens	13-18
24816737-3	2014	SIRT1 protein expression in a paraffin-embedded tissue microarray, including 13 benign adenomas, nine liver metastasis tissues, and 120 paired colorectal cancer and normal mucosa tissues, was measured by immunohistochemistry.	Paraffin	30-38	sirtuin 1	Homo sapiens	0-5
16006099-4	2005	Expression of TLR4 in paraffin-embedded sections was analyzed by immunohistochemistry.	Paraffin	22-30	toll like receptor 4	Homo sapiens	14-18
24242681-3	2014	METHODS: Immunohistochemical staining of Glut1 and CD34 was performed using paraffin-embedded sections of tissues obtained from 145 resectable esophageal squamous cell carcinoma patients without preoperative treatment.	Paraffin	76-84	solute carrier family 2 member 1	Homo sapiens	41-46
16224591-1	2005	In situ hybridization on paraffin sections of the rat brain showed that synthetic peptides Vilon, Epithalon, and Cortagen modulated the expression of IL-2 gene in vivo in cells of some hypothalamic structures depending on the terms and routes of administration.	Paraffin	25-33	interleukin 2	Rattus norvegicus	150-154
24594115-6	2014	MATERIALS AND METHODS: Pyrosequencing and Sanger sequencing were performed to identify KRAS and BRAF mutations in paraffin-embedded samples of CRC.	Paraffin	114-122	KRAS proto-oncogene, GTPase	Homo sapiens	87-91
15785748-7	2005	Owing to its potential as a novel therapeutic marker, expression of the high-affinity epithelial receptor for Clostridium perfringens enterotoxin (CPE) claudin-4 was further validated through immunohistochemical analysis of formalin-fixed paraffin-embedded specimens from which the primary USPC cultures were obtained, as well as an independent set of archival USPC specimens.	Paraffin	239-247	cpe	Clostridium perfringens	110-145
15785748-7	2005	Owing to its potential as a novel therapeutic marker, expression of the high-affinity epithelial receptor for Clostridium perfringens enterotoxin (CPE) claudin-4 was further validated through immunohistochemical analysis of formalin-fixed paraffin-embedded specimens from which the primary USPC cultures were obtained, as well as an independent set of archival USPC specimens.	Paraffin	239-247	cpe	Clostridium perfringens	147-150
24659264-5	2014	We compared the expression level of miR-23a in DLBCL patients (n = 104) and reactive lymph nodes as controls (n = 28) from formalin-fixed, paraffin-embedded tissues using quantitative reverse transcription-polymerase chain reaction.	Paraffin	139-147	microRNA 23a	Homo sapiens	36-43
15730516-12	2005	Their high reactivity in paraffin-embedded tissues opens up opportunities to study possible changes in the pattern of ACE expression in knockout mouse models and may prove useful for correlating ACE expression in these models with human diseases.	Paraffin	25-33	angiotensin I converting enzyme (peptidyl-dipeptidase A) 1	Mus musculus	118-121
24944654-6	2014	Glut-1, HIF-1alpha, PI3K and phosphorylated-Akt (p-Akt) expression was detected by immunohistochemical staining of paraffin sections from the tumor specimens.	Paraffin	115-123	solute carrier family 2 member 1	Homo sapiens	0-6
15586235-4	2005	TMA analysis was applied on a distinct series of 36 formalin-fixed, paraffin-embedded DLCL samples and showed that TCL1A immunoexpression was correlated with either higher relapse (p=0.02) or lower 5-year overall survival (p=0.009) rates.	Paraffin	68-76	TCL1 family AKT coactivator A	Homo sapiens	115-120
24625077-6	2014	Immunohistochemistry with anti-TSPO antibody was performed on paraffin-embedded sections.	Paraffin	62-70	translocator protein	Rattus norvegicus	31-35
24776766-6	2014	Transient receptor potential channel melastatin subtype 6 (TRPM6) was detected by immunohistochemistry in paraffin-embedded renal biopsy sections of 12 GS patients.	Paraffin	106-114	transient receptor potential cation channel subfamily M member 6	Homo sapiens	0-57
24776766-6	2014	Transient receptor potential channel melastatin subtype 6 (TRPM6) was detected by immunohistochemistry in paraffin-embedded renal biopsy sections of 12 GS patients.	Paraffin	106-114	transient receptor potential cation channel subfamily M member 6	Homo sapiens	59-64
15536326-5	2004	The same paraffin block was retrieved for 34betaE12 and p63 stains.	Paraffin	9-17	tumor protein p63	Homo sapiens	56-59
23904219-2	2014	NLK expression was evaluated by Western blot in 8 paired fresh non-small-cell lung cancer (NSCLC) tissues and immunohistochemistry (IHC) on 83 paraffin-embedded slices.	Paraffin	143-151	nemo like kinase	Homo sapiens	0-3
15627061-2	2004	METHODS: S6K1/2 expression and phosphorylated ribosomal S6 protein (phS6) content have been detected in formalin fixed, paraffin embedded sections of 50 human endometrial adenocarcinomas with different grade of differentiation and in 13 normal endometrial tissues using immunohistochemical approach with following semiquantitative analysis.	Paraffin	120-128	ribosomal protein S6 kinase B1	Homo sapiens	9-15
24108439-2	2014	METHODS: Immunostaining with a FAS antibody was performed on paraffin-embedded prostate biopsy cores with GS 5-6 obtained from 80 patients who subsequently underwent RP.	Paraffin	61-69	fatty acid synthase	Homo sapiens	31-34
15325567-2	2004	Toll-like receptor-4 and CD14 proteins were detected by immunohistochemical analysis of sections of whole human eyes embedded in paraffin with monoclonal antibodies against human toll-like receptor-4 (HTA-125), human CD14 (RPA-M1), or as a control, an irrelevant mouse IgG1k (MOPC-21).	Paraffin	129-137	toll like receptor 4	Homo sapiens	0-20
15283850-5	2004	Extensive analysis of a large panel of paraffin-embedded human tissues revealed that the 314G8 mAb detected MAdCAM-1 on venules in the spleen and small intestine.	Paraffin	39-47	mucosal vascular addressin cell adhesion molecule 1	Homo sapiens	108-116
24427349-4	2014	The expression level of ASAP1 in 95 paraffin-embedded EOC specimens was measured by immunohistochemistry staining.	Paraffin	36-44	ArfGAP with SH3 domain, ankyrin repeat and PH domain 1	Homo sapiens	24-29
15270885-9	2004	RESULTS: We found nuclear beta-catenin in 20 of 86 paraffin-embedded sections of BCCs using immunohistochemistry.	Paraffin	51-59	catenin beta 1	Homo sapiens	26-38
23937454-4	2013	Sam68 protein expression and localization were determined in 224 paraffin-embedded archived CRC samples using immunohistochemistry.	Paraffin	65-73	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	0-5
15454013-2	2004	METHODS: ADAM8 and ADAM12 was detected by immunohistochemistry (SP) in 40 paraffin-embedded specimens of central giant cell lesions of jaw, 10 peripheral giant cell lesions, 9 cherubisms, 6 aneurysmal bone cysts.	Paraffin	74-82	ADAM metallopeptidase domain 8	Homo sapiens	9-14
23708264-4	2013	Immunohistochemistry was used to examine Cathepsin B expression in 76 paraffin-embedded endometrial tumor tissues.	Paraffin	70-78	cathepsin B	Homo sapiens	41-52
15169792-3	2004	MATERIALS AND METHODS: Immunohistochemistry was used to detect active, tyrosine-phosphorylated Stat5 in paraffin-embedded breast cancer specimens from three archival tissue microarray materials A, B, and C. Material A included 19 healthy human breast tissues and a progression series of primary lymph node-negative, primary lymph node-positive, and metastatic breast cancer (n = 400).	Paraffin	104-112	signal transducer and activator of transcription 5A	Homo sapiens	95-100
23292229-1	2013	Short-chain chlorinated paraffins (SCCPs) are extremely complex technical mixtures of polychlorinated n-alkanes with carbon chain lengths from C10 to C13 and chlorine content between 49 and 70%.	Paraffin	24-33	chromosome 12 open reading frame 57	Homo sapiens	143-146
23292229-1	2013	Short-chain chlorinated paraffins (SCCPs) are extremely complex technical mixtures of polychlorinated n-alkanes with carbon chain lengths from C10 to C13 and chlorine content between 49 and 70%.	Paraffin	24-33	homeobox C13	Homo sapiens	150-153
14689303-4	2004	Immunohistochemical staining for PTEN protein was performed with the labeled streptavidin-biotin method on formalin-fixed and paraffin-embedded tissue samples.	Paraffin	126-134	phosphatase and tensin homolog	Homo sapiens	33-37
23592755-2	2013	In this report, we surveyed 924 miRNA (miR) for their expressions in the formalin-fixed paraffin-embedded specimens from 42 patients with SCLC, and found that the downregulated miR-886-3p is closely correlated with the shorter survival of SCLC.	Paraffin	88-96	vault RNA 2-1	Homo sapiens	177-184
23540296-6	2013	Acyl-CoA thioesterase 8 isoform c (ACOT8) was one of most overexpressed proteins in the metastatic group, and it was validated by Western blot and immunohistochemical staining on 108 paraffin-embedded tumor samples.	Paraffin	183-191	acyl-CoA thioesterase 8	Homo sapiens	0-23
23540296-6	2013	Acyl-CoA thioesterase 8 isoform c (ACOT8) was one of most overexpressed proteins in the metastatic group, and it was validated by Western blot and immunohistochemical staining on 108 paraffin-embedded tumor samples.	Paraffin	183-191	acyl-CoA thioesterase 8	Homo sapiens	35-40
14966910-2	2004	METHODS: Expression of HIF-2alpha/EPAS1 was investigated immunohistochemically on paraffin-embedded sections from 97 patients with HCC.	Paraffin	82-90	endothelial PAS domain protein 1	Homo sapiens	23-33
14966910-2	2004	METHODS: Expression of HIF-2alpha/EPAS1 was investigated immunohistochemically on paraffin-embedded sections from 97 patients with HCC.	Paraffin	82-90	endothelial PAS domain protein 1	Homo sapiens	34-39
15059327-2	2004	METHODS: The expression of hTERT protein and hTERT mRNA in the formalin-fixed paraffin-embedded specimens of 71 cases of bile duct cancers and 39 cases of adjacent tissues was detected by streptavidin-peroxidase immunostaining and in situ hybridization.	Paraffin	78-86	telomerase reverse transcriptase	Homo sapiens	27-32
23108567-6	2013	RESULTS: KRAS mutations in codons 12 and 13 were present in 37.6 % of analyzed formalin-fixed paraffin-embedded (FFPE) DNA samples.	Paraffin	94-102	KRAS proto-oncogene, GTPase	Homo sapiens	9-13
23928533-2	2013	METHODS: Real-time PCR was used to detect the presence of EML4-ALK fusion gene in 268 cases of NSCLCs using paraffin-embedded tissue samples(among which 164 samples were re-validated by Sanger sequencing).	Paraffin	108-116	EMAP like 4	Homo sapiens	58-62
15491060-5	2004	An indirect immunoperoxidase method was applied using polyclonal antibodies against HSP70 and HSP90 on formalin-fixed paraffin-embedded tissues.	Paraffin	118-126	heat shock protein 90 alpha family class A member 1	Homo sapiens	94-99
14675129-6	2004	Epithelial expression was further proven by immunofluorescence staining of MT1 in paraffin-embedded cholelithiasis and gallbladder carcinoma sections.	Paraffin	82-90	metallothionein 1I, pseudogene	Homo sapiens	75-78
23063585-0	2013	Assessment of FANCD2 nuclear foci formation in paraffin-embedded tumors: a potential patient-enrichment strategy for treatment with DNA interstrand crosslinking agents.	Paraffin	47-55	FA complementation group D2	Homo sapiens	14-20
23249834-3	2013	We studied germline and somatic mutations of the CYLD gene by direct sequencing in patients with BSS (n = 49) and MFT (n = 18) using peripheral blood and 90 samples of frozen or formalin-fixed paraffin-embedded tumor tissue selected from 379 available histology specimens.	Paraffin	193-201	CYLD lysine 63 deubiquitinase	Homo sapiens	49-53
24133623-12	2013	Using HRM and TaqMan warrants high-quality and rapid-routine KRAS mutation detection in paraffin-embedded tumor specimens.	Paraffin	88-96	KRAS proto-oncogene, GTPase	Homo sapiens	61-65
24049650-3	2012	Immunohistochemical techniques were used to examine the accumulation of the proinflammatory cytokine IL-17 in forty (n = 40) formalin-fixed, paraffin-embedded oesophageal archived specimens across a range of endoscopic diagnostic categories, and a highly significant difference was found, where P &lt;= 0.001, in IL-17 expression (Kruskall Wallis and Mann-Whitney U) between all the cell types examined.	Paraffin	141-149	interleukin 17A	Homo sapiens	101-106
22549289-3	2012	METHODS: JAM-A antigen expression was investigated retrospectively by immunohistochemistry in paraffin-embedded primary tumor tissue samples from a series (n = 186) of consecutive patients with pancreatic adenocarcinoma.	Paraffin	94-102	F11 receptor	Homo sapiens	9-14
23252871-6	2012	Our reverse transcription-polymerase chain reaction using the formalin-fixed, paraffin-embedded tumor tissues detected EWSR1-CREB1 fusion transcript, but could not demonstrate EWSR1-ATF1 fusion or EWSR1/TAF15/TFG-NR4A3 fusion.	Paraffin	78-86	cAMP responsive element binding protein 1	Homo sapiens	125-130
23226727-4	2012	We observed KRAS mutations in formalin-fixed, paraffin-embedded tissues by PCR direct sequencing and in blood samples by PNA clamp PCR.	Paraffin	46-54	KRAS proto-oncogene, GTPase	Homo sapiens	12-16
23172529-3	2012	The mutation of exon 2 of K-ras was detected in primary paraffin-embedded lesions by PCR and Pyrosequencing.	Paraffin	56-64	KRAS proto-oncogene, GTPase	Homo sapiens	26-31
23302487-0	2012	[Correlation of miR-155 on formalin-fixed paraffin embedded tissues with invasiveness and prognosis of breast cancer].	Paraffin	42-50	microRNA 155	Homo sapiens	16-23
22472959-6	2012	MDM2 amplification was analyzed using FISH on formalin-fixed, paraffin-embedded material in 26 cases.	Paraffin	62-70	MDM2 proto-oncogene	Homo sapiens	0-4
22691236-11	2012	IHC analysis of paraffin blocks from Asian Caucasian patients demonstrated that the frequency of PAFAH1B1 protein overexpression was 68% in Asian and 70% in Caucasian.	Paraffin	16-24	platelet activating factor acetylhydrolase 1b regulatory subunit 1	Homo sapiens	97-105
22418702-4	2012	Therefore, we screened 99 primary breast cancer samples by immunohistochemistry analysis using formalin-fixed paraffin-embedded archival tumor tissues and confirmed that mesothelin was overexpressed in the majority of TNBC (67 %) but only rarely in &lt;5 % ER(+) or Her2-neu(+) breast cancer, respectively.	Paraffin	110-118	mesothelin	Homo sapiens	170-180
22702496-2	2012	MATERIALS AND METHODS: The CD44+/CD24- CSC ratio was determined in formalin-fixed, paraffin-embedded breast cancer tissues from 1350 breast cancer patients by double immunofluorescence staining.	Paraffin	83-91	CD44 molecule (Indian blood group)	Homo sapiens	27-31
22555094-0	2012	Applicability of a System for fully automated nucleic acid extraction from formalin-fixed paraffin-embedded sections for routine KRAS mutation testing.	Paraffin	90-98	KRAS proto-oncogene, GTPase	Homo sapiens	129-133
22041016-4	2012	DESIGN: Immunohistochemical analysis using anti-VDR antibody was performed in paraffin sections of mouse mandibles at E13, E14, E17, P10, and P35.	Paraffin	78-86	vitamin D (1,25-dihydroxyvitamin D3) receptor	Mus musculus	48-51
22480210-1	2012	The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, and (iii) quantitative reverse-transcriptase PCR.	Paraffin	109-117	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	22-51
22480210-1	2012	The expression of the plasma membrane Ca(2+) ATPase (PMCA) was analyzed in a series of 84 formalin-fixed and paraffin embedded colon samples including normal mucosa (n = 32), adenoma (n = 19), adenocarcinoma (n = 27), and lymph node metastasis (n = 6) using (i) immunohistochemistry, (ii) mRNA in situ hybridization, and (iii) quantitative reverse-transcriptase PCR.	Paraffin	109-117	ATPase plasma membrane Ca2+ transporting 2	Homo sapiens	53-57
22722791-3	2012	METHODS: We developed an assay system for the detection of EML4-ALK variants 1, 2, 3a, 3b, 4, 5a, 5b, 6, or 7 transcripts in total RNA obtained from formalin-fixed, paraffin-embedded (FFPE) specimens of NSCLC tissue.	Paraffin	165-173	EMAP like 4	Homo sapiens	59-63
22722791-3	2012	METHODS: We developed an assay system for the detection of EML4-ALK variants 1, 2, 3a, 3b, 4, 5a, 5b, 6, or 7 transcripts in total RNA obtained from formalin-fixed, paraffin-embedded (FFPE) specimens of NSCLC tissue.	Paraffin	165-173	ALK receptor tyrosine kinase	Homo sapiens	64-67
21615452-5	2012	The presence of IL-18 in human testicular cells was examined by immunohistochemical staining of paraffin-embedded sections, using a specific antibody for human IL-18.	Paraffin	96-104	interleukin 18	Homo sapiens	16-21
21936856-8	2012	CD16+ cells infiltrating the epidermis and detected at the dermoepidermal junction were immunostained and counted in paraffin-embedded skin sections obtained from 47 patients with drug rash manifested as TEN, SJS, maculopapular-type rash or erythema multiform-type rash.	Paraffin	117-125	Fc gamma receptor IIIa	Homo sapiens	0-4
22173329-0	2012	Analytical performance of a PCR assay for the detection of KRAS mutations (codons 12/13 and 61) in formalin-fixed paraffin-embedded tissue samples of colorectal carcinoma.	Paraffin	114-122	KRAS proto-oncogene, GTPase	Homo sapiens	59-63
22240294-6	2012	METHODS: By means of immunohistochemistry and quantitative real-time PCR, we determined SGK1 protein and mRNA expression in a cohort of 66 formalin-fixed, paraffin-embedded NSCLC surgical samples.	Paraffin	155-163	serum/glucocorticoid regulated kinase 1	Homo sapiens	88-92
22745546-8	2012	Examination of paraffin sections of tumor tissues stained for the iron constituent of the NPs with Prussian blue revealed a strong blue reaction in the tumors of anti-VEGF-NP-treated mice, but only a weak reaction in mice injected with NPs.	Paraffin	15-23	vascular endothelial growth factor A	Mus musculus	167-171
22347464-0	2012	KLC1-ALK: a novel fusion in lung cancer identified using a formalin-fixed paraffin-embedded tissue only.	Paraffin	74-82	kinesin light chain 1	Mus musculus	0-4
15188025-1	2004	P27 expression was examined on paraffin-embedded specimens in proliferative, secretory, hyperplastic and neoplastic human endometrium by immunohistochemistry.	Paraffin	31-39	interferon alpha inducible protein 27	Homo sapiens	0-3
14602802-5	2003	One of these mAbs reacts with the LHR/hCGR in tissue sections of both frozen and paraffin-embedded specimens.	Paraffin	81-89	luteinizing hormone/choriogonadotropin receptor	Homo sapiens	34-37
21277811-7	2012	Furthermore, BCL6 protein expression was assessed in 13 archived paraffin-embedded high-grade canine lymphoma tissues and all were also negative.	Paraffin	65-73	BCL6 transcription repressor	Canis lupus familiaris	13-17
14519634-5	2003	RESULTS: TS mRNA expression determined by real-time reverse transcription-PCR correlated with TS protein levels determined by TS immunoblot and immunohistochemistry in cultured colon cancer cell lines and paraffin-embedded primary tumor tissue.	Paraffin	205-213	thymidylate synthetase	Homo sapiens	5-7
20950219-3	2011	We aimed to validate cytokeratin 8 (CK 8) immunohistochemistry as an alternative that works on paraffin sections.	Paraffin	95-103	keratin 8	Homo sapiens	21-34
14653109-0	2003	[Amplification of beta-catenin gene in the paraffin-embedded epidermal tissue].	Paraffin	43-51	catenin beta 1	Homo sapiens	18-30
20950219-3	2011	We aimed to validate cytokeratin 8 (CK 8) immunohistochemistry as an alternative that works on paraffin sections.	Paraffin	95-103	keratin 8	Homo sapiens	36-40
14653109-2	2003	METHODS: Exon 3 of the beta-catenin gene was amplified by PCR in 14 paraffin-embedded Bowen"s disease (BD) of various weight and years.	Paraffin	68-76	catenin beta 1	Homo sapiens	23-35
21999583-2	2011	We investigated DMBT1 in 56 paraffin embedded specimens of transitional cell carcinoma of the urinary bladder.	Paraffin	28-36	deleted in malignant brain tumors 1	Homo sapiens	16-21
12872724-6	2003	Beta-catenin accumulation was examined immunohistochemically in 49 frozen or formalin-fixed, paraffin-embedded samples of head and neck tumors.	Paraffin	93-101	catenin beta 1	Homo sapiens	0-12
12738061-6	2003	Detection of Hsp70 was achieved by an ABC technique in vibratome or paraffin sections combined with specific markers of glial cell types.	Paraffin	68-76	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	13-18
21706236-10	2011	The up-regulation of NDRG1 was verified in osteosarcoma through Western blotting and by immunohistochemistry in paraffin-embedded tissues.	Paraffin	112-120	N-myc downstream regulated 1	Homo sapiens	21-26
12478673-4	2003	Retrospective immunohistochemical analysis of RARalpha protein expression was carried out in paraffin-embedded tissue sections from 115 patients with completely resected oral SCCs for whom clinical follow-up data were available.	Paraffin	93-101	retinoic acid receptor alpha	Homo sapiens	46-54
20945089-8	2011	Upregulation of HOXB13 was seen in malignant relative to borderline phyllodes tumors and further investigated by immunohistochemistry in a corresponding set of formalin-fixed, paraffin-embedded tumors.	Paraffin	176-184	homeobox B13	Homo sapiens	16-22
12518886-3	2003	PROCEDURE: Immunohistochemical analysis was used to detect lysozyme and lactoferrin in formalin-fixed, paraffin-embedded sections of the ocular glands.	Paraffin	103-111	lactotransferrin	Bos taurus	72-83
21516079-3	2011	We report our experience of routine KRAS/BRAF mutation screening practice performed on 1130 formalin-fixed paraffin-embedded tumor samples from 992 colorectal cancer patients.	Paraffin	107-115	KRAS proto-oncogene, GTPase	Homo sapiens	36-40
21516079-11	2011	Routine KRAS genotyping performed on formalin-fixed paraffin-embedded tissues requires, therefore, the development of quality control scheme for molecular pathology, especially because of DNA damages induced by formalin fixation.	Paraffin	52-60	KRAS proto-oncogene, GTPase	Homo sapiens	8-12
12517806-6	2003	Immunohistochemical staining of paraffin-fixed NPC sections confirmed that MMP-1 protein was expressed in the epithelial tumor cells.	Paraffin	32-40	matrix metallopeptidase 1	Homo sapiens	75-80
21493867-6	2011	Evi-1 protein expression could be confirmed in formalin-fixed, paraffin-embedded samples of 26 of 28 infratentorial ependymomas but only in 7 of 47 nonependymal glial tumors (P &lt; 0.001).	Paraffin	63-71	MDS1 and EVI1 complex locus	Homo sapiens	0-5
21277011-9	2011	In the paraffin-embedded specimens we tested, c-abl was expressed universally.	Paraffin	7-15	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	46-51
21294144-5	2011	Claudin-1 and occludin were detected in paraffin-embedded liver biopsies obtained during reperfusion and 3 and 12 months after LT. HCV receptors were characterized by confocal immunofluorescence microscopy; quantification and colocalization studies were performed with dedicated software.	Paraffin	40-48	claudin 1	Homo sapiens	0-9
15072490-7	2003	METHODS: The expression of p27 protein was immunohistochemically analyzed in paraffin-embedded specimens of 75 patients with transitional cell carcinoma of the bladder.	Paraffin	77-85	interferon alpha inducible protein 27	Homo sapiens	27-30
21378549-5	2011	In this study, we investigated the potential diagnostic use of immunostaining for FOXL2 on formalin-fixed paraffin-embedded tissue sections.	Paraffin	106-114	forkhead box L2	Homo sapiens	82-87
14965710-2	2002	on c-myc gene amplification and protein overexpression in apocrine metaplasia (APM) and apocrine adenosis (AA) of the breast using paraffin-embedded tissue.	Paraffin	131-139	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	3-8
21279521-12	2011	We conclude that immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts in formalin-fixed, paraffin-embedded tissues are powerful tools in the diagnosis of ASPS, particularly in cases with unusual morphologic features.	Paraffin	125-133	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	77-81
21279521-12	2011	We conclude that immuno-detection of TFE3 and RT-PCR-based identification of ASPL/TFE3 fusion transcripts in formalin-fixed, paraffin-embedded tissues are powerful tools in the diagnosis of ASPS, particularly in cases with unusual morphologic features.	Paraffin	125-133	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	190-194
21118047-5	2011	RESULTS: A total of 70 alleles of somatic mutations of EGFR, KRAS, BRAF and PIK3CA can be detected simultaneously in one reaction from one formalin-fixed and paraffin-embedded (FFPE) slide within one day.	Paraffin	158-166	KRAS proto-oncogene, GTPase	Homo sapiens	61-65
12460204-10	2002	CONCLUSIONS: Ki67 and PCNA immunostaining in paraffin sections may be useful for the prediction of survival in patients with anorectal malignant melanoma.	Paraffin	45-53	proliferating cell nuclear antigen	Homo sapiens	22-26
20926413-8	2011	CONCLUSIONS: These data suggest that the evaluation of DNA amplificability and amplicon size is important for the success of mutation detection tests such as the KRAS test with dideoxy sequencing using formalin-fixed and paraffin-embedded tissue samples in the clinical setting.	Paraffin	221-229	KRAS proto-oncogene, GTPase	Homo sapiens	162-166
12204056-3	2002	DESIGN: beta-Catenin mutation in exon 3 was studied using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) and direct sequencing analysis in 30 formalin-fixed, paraffin-embedded liposarcomas.	Paraffin	188-196	catenin beta 1	Homo sapiens	8-20
21052001-0	2010	High sensitivity of reverse-hybridization methodology in the detection of KRAS mutations from formalin-fixed paraffin-embedded colorectal cancer samples.	Paraffin	109-117	KRAS proto-oncogene, GTPase	Homo sapiens	74-78
21052001-5	2010	We evaluated the performance of a reverse-hybridization-based assay in the identification of the most frequent KRAS mutations on a series of 50 formalin-fixed, paraffin-embedded, advanced colorectal cancer specimens, in comparison with the direct gene sequencing technique.	Paraffin	160-168	KRAS proto-oncogene, GTPase	Homo sapiens	111-115
21052001-10	2010	Both reverse hybridization and gene sequencing methods have been shown to be suitable tests in detecting KRAS mutations from formalin-fixed, paraffin-embedded tumor specimens.	Paraffin	141-149	KRAS proto-oncogene, GTPase	Homo sapiens	105-109
20801641-2	2010	METHODS: Immunoreactivity of MMP-9 and TIMP-1 by carcinoma cells, lymphocytes and fibroblasts in archival specimens of paraffin-embedded primary tumours were retrospectively associated with outcome in 340 consecutive patients completely resected for CRC stages II-IV and subsequently treated with adjuvant 5-fluorouracil.	Paraffin	119-127	matrix metallopeptidase 9	Homo sapiens	29-34
12814187-1	2002	Monoclonal antibody hepatocyte paraffin 1 (Hep Par 1) is reported to be highly specific and sensitive for hepatocellular tumours of humans and dogs.	Paraffin	31-39	Prader Willi/Angelman region RNA 1	Homo sapiens	47-52
12115529-5	2002	Immunoreactivity for maspin and p53 antibodies with paraffin-embedded carcinoma tissue was investigated using labeled streptavidin-biotin methods.	Paraffin	52-60	serpin family B member 5	Homo sapiens	21-27
12400605-10	2002	Immunohistochemical stains performed on paraffin sections from these 6 representative cases showed differential protein expression of MLH1, MSH2, MSH6, and PMS2 when compared to normal reactive tissues from the same patient but showed no significant differences when compared to controls of non-familial, sporadic lymphomas.	Paraffin	40-48	mutL homolog 1	Homo sapiens	134-138
21299161-2	2010	Pathologists have a crucial role in accurate testing for KRAS mutations, whether or not testing is performed in their own laboratory, as mutation analysis is performed on paraffin embedded tissue selected by the pathologists.	Paraffin	171-179	KRAS proto-oncogene, GTPase	Homo sapiens	57-61
12400605-10	2002	Immunohistochemical stains performed on paraffin sections from these 6 representative cases showed differential protein expression of MLH1, MSH2, MSH6, and PMS2 when compared to normal reactive tissues from the same patient but showed no significant differences when compared to controls of non-familial, sporadic lymphomas.	Paraffin	40-48	mutS homolog 6	Homo sapiens	146-150
12400605-10	2002	Immunohistochemical stains performed on paraffin sections from these 6 representative cases showed differential protein expression of MLH1, MSH2, MSH6, and PMS2 when compared to normal reactive tissues from the same patient but showed no significant differences when compared to controls of non-familial, sporadic lymphomas.	Paraffin	40-48	PMS1 homolog 2, mismatch repair system component	Homo sapiens	156-160
12160289-4	2002	Immunohistochemical studies were performed to evaluate the expression of proliferating cell nuclear antigen (PCNA) on archival paraffin-embedded blocks.	Paraffin	127-135	proliferating cell nuclear antigen	Homo sapiens	73-107
20041308-3	2010	As rarely reported previously, the MLPA assay was also used to examine DNA from formalin fixed paraffin embedded (FFPE) normal tissues of other affected subjects in the family and it was the only effective method to perform a complete segregation analysis of the BRCA1 ins6kbEx13 mutation in the family.	Paraffin	95-103	BRCA1 DNA repair associated	Homo sapiens	263-268
20714877-2	2010	Real-time quantitative RT-PCR (Taqman) was used to detect the mRNA expression of TS, TP and DPD in formalin-fixed and paraffin-embedded 106 samples of epithelial ovarian cancer and 29 normal ovaries.	Paraffin	118-126	dihydropyrimidine dehydrogenase	Homo sapiens	92-95
12160289-4	2002	Immunohistochemical studies were performed to evaluate the expression of proliferating cell nuclear antigen (PCNA) on archival paraffin-embedded blocks.	Paraffin	127-135	proliferating cell nuclear antigen	Homo sapiens	109-113
12019169-8	2002	To verify the overexpression in patient samples, two of the overexpressed genes, c-Myc and Rad51, were selected to undergo analysis by reverse transcription-PCR in frozen tumor tissues and by immunostaining in paraffin-embedded tissue section microarrays.	Paraffin	210-218	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	81-86
20712532-5	2010	By using this assay, we determined the mutational status of KRAS in 527 out of 540 (97.6%) formalin-fixed paraffin-embedded tissues from mCRC patients.	Paraffin	106-114	KRAS proto-oncogene, GTPase	Homo sapiens	60-64
20388062-4	2010	MATERIALS AND METHODS: NDRG1 was detected at its protein level by immunohistochemistry in formalin-fixed and paraffin-embedded sections with a total of 110 pair gastric cancer specimens including tumor and corresponding paraneoplastic tissues; NDRG1 mRNA was detected by real time-polymerase chain reaction.	Paraffin	109-117	N-myc downstream regulated 1	Homo sapiens	23-28
12575349-2	2002	METHODS: MMP1 and TIMP1 proteins were detected with the immunohistochemical method of avidin-biotin complex in formalin-fixed and routinely paraffin-embeded specimens of 46 patients.	Paraffin	140-148	matrix metallopeptidase 1	Homo sapiens	9-13
21122411-2	2010	METHODS: EnVision(TM) immunohistochemical staining was used to detect the expression of ANXA1 and ANXA2 in paraffin-embedded tissue sections from resected specimens of adenocarcinoma (n = 108), peritumoral tissue (n = 46), adenomatous polyp (n = 15) and chronic cholecystitis (n = 35).	Paraffin	107-115	annexin A1	Homo sapiens	88-93
26680852-5	2002	MATERIALS AND METHODS: Immunohistochemical expression of beta-catenin was studied in 7 normal livers, 33 hepatocellular carcinomas and 20 cholangiocarcinomas, that were formalin fixed and paraffin embedded.	Paraffin	188-196	catenin beta 1	Homo sapiens	57-69
20571343-3	2010	We developed a nested RT-PCR assay for tyrosinase applicable on paraffin-embedded tissue and applied this to a series of SLNs from pediatric patients with melanoma.	Paraffin	64-72	tyrosinase	Homo sapiens	39-49
20571343-12	2010	The application of RT-PCR for tyrosinase to paraffin-embedded tissue significantly increased the number of positive SLNs and upstaged one patient from negative to positive.	Paraffin	44-52	tyrosinase	Homo sapiens	30-40
12239454-5	2002	METHODS: Using a monoclonal antibody against p27, immunohistochemistry was performed in paraffin-embedded tumor specimens from 316 patients.	Paraffin	88-96	interferon alpha inducible protein 27	Homo sapiens	45-48
20834076-11	2010	Well designed studies are needed to further investigate the performance of various anti-BRCA1 antibodies in formalin- fixed paraffin-embedded tissue samples, assess their association with BRCA1 gene mutations and determine clinical usefulness of BRCA1 immunohistochemistry.	Paraffin	124-132	BRCA1 DNA repair associated	Homo sapiens	88-93
11511839-3	2001	A new CD7 antibody, the most sensitive and specific T-cell deletion marker, and a new TCR-gamma gene rearrangement polymerase chain reaction (PCR) assay (TCR-gamma PCR) are now available on routine paraffin-embedded biopsy specimens.	Paraffin	198-206	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	86-89
20431034-3	2010	Therefore, we assessed Sanger sequencing, pyrosequencing, and melting curve analysis for the detection of KRAS codon 12/13 mutations in formalin-fixed paraffin-embedded samples, including 58 primary and 42 metastatic colorectal adenocarcinomas, 63 primary and 17 metastatic lung adenocarcinomas, and 20 normal colon samples.	Paraffin	151-159	KRAS proto-oncogene, GTPase	Homo sapiens	106-110
11511839-3	2001	A new CD7 antibody, the most sensitive and specific T-cell deletion marker, and a new TCR-gamma gene rearrangement polymerase chain reaction (PCR) assay (TCR-gamma PCR) are now available on routine paraffin-embedded biopsy specimens.	Paraffin	198-206	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	154-157
20573258-2	2010	miRs may be less prone to degradation during formalin fixation, facilitating miR expression studies in formalin-fixed paraffin-embedded (FFPE) tissue.	Paraffin	118-126	membrane associated ring-CH-type finger 8	Homo sapiens	0-3
11493379-4	2001	Then the specimens were analyzed for TCR gene rearrangement either on paraffin-embedded or fresh-frozen tissue by PCR/denaturing gradient gel electrophoresis (DGGE).	Paraffin	70-78	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	37-40
11493379-12	2001	CONCLUSIONS: Our data have demonstrated that TCR gene rearrangement studies by PCR/DGGE are consistently positive regardless of tissue fixation (formalin-fixed, paraffin-embedded vs. fresh-frozen tissue) and biopsy site when the histologic degree of confidence is very high (diagnostic).	Paraffin	161-169	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	45-48
21055154-4	2010	AnnexinA3 expression was examined by streptavidin peroxidase immunohistochemical technique on paraffin-embedded tissue sections from 50 patients of gallbladder cancer and 38 cases of chronic eholecystitis.	Paraffin	94-102	annexin A3	Homo sapiens	0-9
11557838-4	2001	Cyclin D1 expression was evaluated in 105-day fetal dorsal subcutaneous tissues using paraffin sections.	Paraffin	86-94	cyclin D1	Sus scrofa	0-9
20537279-5	2010	Paraffin blocks were used to identify the expression of ADAM-33 polyclonal antibodies.	Paraffin	0-8	ADAM metallopeptidase domain 33	Homo sapiens	56-63
11549509-2	2001	METHODS: The expression of three negative regulators of the cell cycle, the retinoblastoma gene product (pRb), the WAF1/Cip1 gene product (p21), and the Kip1 gene product (p27), was investigated by immunohistochemistry on paraffin sections from 104 formalin-fixed clear cell carcinoma specimens and related to p53 overexpression, the clinicopathologic parameters, and survival.	Paraffin	222-230	interferon alpha inducible protein 27	Homo sapiens	172-175
20090517-2	2010	A new monoclonal antibody, CON6D/B5, directed against the CD30 antigen has become commercially available for use in formalin-fixed paraffin-embedded tissue samples.	Paraffin	131-139	TNF receptor superfamily member 8	Homo sapiens	58-62
20367313-10	2010	CONCLUSIONS: A multiplex polymerase chain reaction-based amplification followed by dideoxy-termination sequencing may be used advantageously for the evaluation of KRas and BRaf mutational status from formalin-fixed, paraffin-embedded samples.	Paraffin	216-224	KRAS proto-oncogene, GTPase	Homo sapiens	163-167
11395553-4	2001	Paraffin sections were immunostained with the antibody ALK1.	Paraffin	0-8	activin A receptor like type 1	Homo sapiens	55-59
19747768-7	2010	Cellular localization of SULT1A3 and STS was also assessed by indirect immunofluorescence on paraffin-embedded sections from control and malignant breast tissue clearly showing a correlation of qRT-PCR data with protein expression of these two enzymes.	Paraffin	93-101	sulfotransferase family 1A member 3	Homo sapiens	25-32
11422676-2	2001	Thus, we examined the expression of COX-1 in 16 human temporomandibular joint (TMJ) samples with internal derangement and in 10 control specimens by an immunohistological technique using paraffin-embedded tissue and specific antihuman COX-1 polyclonal antibody.	Paraffin	187-195	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	36-41
19959798-4	2010	Here, we describe a two-step KRAS mutation screening protocol that combines whole-genome amplification (WGA), high-resolution melting analysis (HRM) as a prescreen method for mutation carrying samples, and direct Sanger sequencing of DNA from formalin-fixed, paraffin-embedded (FFPE) tissue, from which limited amounts of DNA are available.	Paraffin	259-267	KRAS proto-oncogene, GTPase	Homo sapiens	29-33
19959798-7	2010	KRAS mutation screening using high-resolution melting analysis on wgaDNA from formalin-fixed, paraffin-embedded tissue is highly sensitive and specific; additionally, this method is feasible for screening of clinical specimens, as illustrated by our analysis of pancreatic cancers.	Paraffin	94-102	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
19959799-0	2010	Detection of BRCA1 and BRCA2 Ashkenazi Jewish founder mutations in formalin-fixed paraffin-embedded tissues using conventional PCR and heteroduplex/amplicon size differences.	Paraffin	82-90	BRCA1 DNA repair associated	Homo sapiens	13-18
19959799-0	2010	Detection of BRCA1 and BRCA2 Ashkenazi Jewish founder mutations in formalin-fixed paraffin-embedded tissues using conventional PCR and heteroduplex/amplicon size differences.	Paraffin	82-90	BRCA2 DNA repair associated	Homo sapiens	23-28
20007841-0	2010	KRAS genotyping of paraffin-embedded colorectal cancer tissue in routine diagnostics: comparison of methods and impact of histology.	Paraffin	19-27	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
11468695-5	2001	METHODS AND RESULTS: We sought to determine whether 25 archival, formalin-fixed, paraffin-embedded PC samples had a modified CYP1A1 gene profile at exon 7 using allele-specific PCR amplification.	Paraffin	81-89	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	125-131
21036242-5	2010	We describe several simple and relatively cheap methods used in our laboratory to study constitutive TSHR mutations that include (1) screening of TSHR gene mutations in paraffin-embedded thyroid tissue samples, (2) measurement of TSHR constitutive activity in vitro, (3) measurement of TSHR expression at cell surface by flow cytometry analysis, (4) TSH binding to TSHR, and (5) TSHR phosphorylation analysis.	Paraffin	169-177	thyroid stimulating hormone receptor	Homo sapiens	101-105
11345832-1	2001	Hepatocyte paraffin 1 (Hep Par 1) is a monoclonal antibody considered almost specific for normal and neoplastic hepatocytes, that can be used on formalin-fixed paraffin-embedded tissues.	Paraffin	11-19	Prader Willi/Angelman region RNA 1	Homo sapiens	27-32
20055949-2	2010	Paraffin-embedded LCH samples were examined on immunohistochemistry and it was found that CD163 can be used to distinguish infiltrated macrophages from neoplastic Langerhans cells (LC).	Paraffin	0-8	CD163 molecule	Homo sapiens	90-95
11345832-1	2001	Hepatocyte paraffin 1 (Hep Par 1) is a monoclonal antibody considered almost specific for normal and neoplastic hepatocytes, that can be used on formalin-fixed paraffin-embedded tissues.	Paraffin	160-168	Prader Willi/Angelman region RNA 1	Homo sapiens	27-32
11241323-4	2001	Expression of the major MT isoforms (MT-1 and MT-2) was determined by immunohistochemistry on paraffin-embedded tumor specimens from 189 patients, 151 suffering from primary epithelial ovarian cancer and 38 from recurrences.	Paraffin	94-102	metallothionein 1I, pseudogene	Homo sapiens	24-50
19308676-4	2009	Levels of CXCR4 expression of a random cohort of patients, who underwent primary curative resection of a colorectal carcinoma, were retrospectively determined by quantitative real-time RT-PCR and semi-quantitative analyses of immunohistochemical stained paraffin sections.	Paraffin	254-262	C-X-C motif chemokine receptor 4	Homo sapiens	10-15
11251954-4	2001	METHODS: The authors analyzed localization and tissue distribution of endostatin in 41 paraffin embedded glioma samples (18 glioblastoma multiforme, 7 WHO Grade III astrocytomas, 13 fibrillary, and 3 protoplasmic WHO Grade II astrocytomas) of human origin and 21 rat C6 gliomas by immunohistochemistry.	Paraffin	87-95	collagen type XVIII alpha 1 chain	Homo sapiens	70-80
19861894-9	2009	To our knowledge, this is the first study to successfully apply UGT1A1 promoter genotyping to formalin-fixed paraffin-embedded tissue, which may facilitate more thorough examination of clinicopathologic correlations.	Paraffin	109-117	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	64-70
19946100-5	2009	METHODS: IHC for MDM2/CDK4 was carried out on a series of 129 paraffin-embedded lipomatous and non-lipomatous soft tissue tumours.	Paraffin	62-70	MDM2 proto-oncogene	Homo sapiens	17-21
11798878-2	2001	METHODS: Immunohistochemistry and in situ hybridization were used to detect the expression of pRB and E(2)F(1) mRNA in the paraffin embedded tissues of 78 cases of human neuroendocrine lung tumor.	Paraffin	123-131	E2F transcription factor 1	Homo sapiens	102-110
11292166-3	2001	Immunocytochemical staining of SMC using monoclonal antisera raised against ASGP-2 and glycosylated ASGP-1 on paraffin-embedded sections of parotid, submaxillary and sublingual tissues was performed to examine the localization of the mucin in the major rat salivary glands.	Paraffin	110-118	mucin 4, cell surface associated	Rattus norvegicus	100-106
11172303-3	2001	It bears the t(X;18) (SYT;SSX) translocation, which seems to be specific for this tumor type and can be detected in paraffin-embedded tissue, using reverse transcriptase-polymerase chain reaction (RT-PCR).	Paraffin	116-124	SSX family member 2B	Homo sapiens	26-29
19695681-4	2009	In this study, we determined the methylation frequency of 5 genes, including p16, Runx3, MGMT, DAPK, and RASSF1A, by methylation-specific polymerase chain reaction, in a series of formalin-fixed paraffin-embedded tissues including normal gastric mucosa (n = 20), intestinal metaplasia (n = 14), gastric epithelial dysplasia (n = 27), and early gastric adenocarcinoma (n = 16).	Paraffin	195-203	Ras association domain family member 1	Homo sapiens	105-112
11172303-12	2001	This study shows that the detection of the SS t(X;18) (SYT-SSX) in paraffin-embedded tissue is feasible with a 100% specificity and an overall 96% sensitivity, provided non-Bouin"s fluid fixation is used.	Paraffin	67-75	SSX family member 2B	Homo sapiens	59-62
11169519-4	2001	Immunohistochemical staining of paraffin sections of prostate tissues revealed that galectin-1 was not detected in normal, PIN (prostatic intraepithelial neoplasia) or carcinoma cells, but accumulated in the stroma and associated fibroblasts.	Paraffin	32-40	galectin 1	Homo sapiens	84-94
19755649-6	2009	Immunohistochemical analysis revealed high SAM68 protein expression in 129 of the 241 (53.5%) paraffin-embedded archival renal cell carcinoma specimens.	Paraffin	94-102	KH RNA binding domain containing, signal transduction associated 1	Homo sapiens	43-48
21340794-18	2001	We describe here a method for immunohistochemistry for hMSH2, hMLH1, and hPMS2 in both fresh and paraffin-embedded material.	Paraffin	97-105	PMS1 homolog 2, mismatch repair system component	Homo sapiens	73-78
19608866-6	2009	By immunohistochemistry, we examined 10 paraffin-embedded ALK(+)ALCL tumors; all cases were positive for both IL-21 and IL-21R in these neoplastic cells.	Paraffin	40-48	ALK receptor tyrosine kinase	Homo sapiens	58-61
11101629-0	2000	A new monoclonal anti-CD3epsilon antibody reactive on paraffin sections.	Paraffin	54-62	CD3 epsilon subunit of T-cell receptor complex	Homo sapiens	22-32
10838025-3	2000	In this study, some practical problems of two common unmasking techniques, i.e. heat-induced epitope retrieval and enzyme digestion have been reviewed in immunostaining of proliferating cell nuclear antigen (PCNA) on formaldehyde-fixed paraffin-embedded sections.	Paraffin	236-244	proliferating cell nuclear antigen	Homo sapiens	172-206
19661338-6	2009	Ki-67 was immunohistochemically analysed in paraffin-embedded tissue.	Paraffin	44-52	antigen identified by monoclonal antibody Ki 67	Mus musculus	0-5
19661358-3	2009	MATERIALS AND METHODS: K-ras analysis was carried out on DNA extracted from paraffin-embedded tumor samples after microdissection.	Paraffin	76-84	KRAS proto-oncogene, GTPase	Homo sapiens	23-28
10838025-3	2000	In this study, some practical problems of two common unmasking techniques, i.e. heat-induced epitope retrieval and enzyme digestion have been reviewed in immunostaining of proliferating cell nuclear antigen (PCNA) on formaldehyde-fixed paraffin-embedded sections.	Paraffin	236-244	proliferating cell nuclear antigen	Homo sapiens	208-212
11314536-4	2000	After the histological process, the paraffin sections were reacted with monoclonal antibodies against rat hsp 70 using the strept-avidin-biotin-peroxidase complex method.	Paraffin	36-44	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	106-112
19594752-11	2009	Paraffin tissue sections of the pigmented skin exhibited granular LC3 accumulation in superficial dermis macrophages.	Paraffin	0-8	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	66-69
11063389-9	2000	The expression of PCNA was evaluated in formalin-fixed, paraffin-embedded gingival samples using an immunoperoxidase technique and PC 10 monoclonal antibody to PCNA.	Paraffin	56-64	proliferating cell nuclear antigen	Homo sapiens	18-22
19430420-12	2009	In conclusion, we validated the utility and superior sensitivity of COLD-PCR for detecting KRAS mutations in a variety of hematopoietic and solid tumors using either fresh or fixed, paraffin-embedded tissue.	Paraffin	182-190	KRAS proto-oncogene, GTPase	Homo sapiens	91-95
11984716-2	2000	The aim of this study was to clarify the relationship between growth activity evaluated by DNA analysis and the concentration of tumor-derived IL-1alpha in gastric cancers in clinical cases.METHODS: We measured the concentration of IL-1alpha in homogenized tumor samples obtained from 49 patients with gastric cancer, using an enzyme-linked immunosorbent assay, and we analyzed the cellular DNA content of paraffin-embedded tumor sections using flow cytometry.RESULTS: Both the IL-1alpha concentration and the percentage of S-phase fraction were significantly correlated with liver metastasis, histologic type, pattern of tumor infiltration, quantity of stroma, and venous invasion.	Paraffin	406-414	interleukin 1 alpha	Homo sapiens	143-152
19363440-0	2009	Utility of microtubule associated protein-2 (MAP-2) immunohistochemistry for identification of ganglion cells in paraffin-embedded rectal suction biopsies.	Paraffin	113-121	microtubule associated protein 2	Homo sapiens	11-43
19363440-9	2009	This study indicates that MAP-2 antibody is a sensitive and specific immunohistochemical marker that can confirm ganglion cells in paraffin-embedded rectal suction biopsies and may eliminate the need for repeat biopsy in select cases.	Paraffin	131-139	microtubule associated protein 2	Homo sapiens	26-31
19568416-10	2009	We further performed a large cohort study (n = 113) to examine the LMO2 messenger RNA levels in formalin-fixed paraffin-embedded samples and found similar results.	Paraffin	111-119	LIM domain only 2	Homo sapiens	67-71
10973889-5	2000	The new conjugate was also used for the immunohistochemical localization of PSA expression in paraffin-embedded prostatic tissues.	Paraffin	94-102	kallikrein related peptidase 3	Homo sapiens	76-79
19242719-0	2009	The detection of CD14 and CD16 in paraffin-embedded bone marrow biopsies is useful for the diagnosis of chronic myelomonocytic leukemia.	Paraffin	34-42	Fc gamma receptor IIIa	Homo sapiens	26-30
19110306-3	2009	METHODS: The indirect immunoperoxidase method was used for Cathepsin-B immunohistochemical staining of 64 paraffin-embedded endometrial tumour tissues, having follow-up period of 18-240 months.	Paraffin	106-114	cathepsin B	Homo sapiens	59-70
10940708-9	2000	CONCLUSIONS: RARalpha expression can be immunohistochemically evaluated in formalin-fixed paraffin-embedded prostatic tissue.	Paraffin	90-98	retinoic acid receptor alpha	Homo sapiens	13-21
19141387-7	2009	The restricted expression pattern, nuclear localization, and crisp staining of LMO2 in paraffin blocks make it an attractive candidate for the diagnostic immunohistochemistry laboratory.	Paraffin	87-95	LIM domain only 2	Homo sapiens	79-83
10814993-3	2000	Clonal expansion of T cells expressing identical TCR V-D-J junction size (Vbeta5-Jbeta1.5) was demonstrated in lymphocyte groups obtained from both bronchoalveolar lavage fluid at relapse, and paraffin embedded lymph node samples resected when he was first diagnosed with angioimmunoblastic T-cell lymphoma.	Paraffin	193-201	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	49-52
19309232-8	2009	The aim of our study was to establish the methods for rapid and sensitive detection of KRAS mutation status in formalin fixed paraffin embedded (FFPE) tissues DNA.	Paraffin	126-134	KRAS proto-oncogene, GTPase	Homo sapiens	87-91
18382348-1	2008	Detection of the tumor-specific fusion gene, FUS-CREB3L2, is useful in the diagnosis of low-grade fibromyxoid sarcoma (LGFMS), especially by reverse transcription (RT)-polymerase chain reaction (PCR) using formalin-fixed, paraffin-embedded (FFPE) tumor tissues.	Paraffin	222-230	cAMP responsive element binding protein 3 like 2	Homo sapiens	49-56
10904880-2	2000	In this study we investigated T-LI and PCNA expression in 68 cases of transitional cell bladder carcinomas in order to evaluate whether PCNA immunostaining in paraffin sections could be a valid alternative to autoradiographic methods for cell kinetic detection.	Paraffin	159-167	proliferating cell nuclear antigen	Homo sapiens	136-140
10794484-2	2000	Because E2F-1 can be detected in paraffin sections using immunohistochemical techniques, it could be a useful tumor/proliferation marker.	Paraffin	33-41	E2F transcription factor 1	Homo sapiens	8-13
18528286-4	2008	We, therefore, examined the expression of FGFR3 by immunohistochemistry in 70 cases of malignant lymphoma using tissue microarrays and whole paraffin sections.	Paraffin	141-149	fibroblast growth factor receptor 3	Homo sapiens	42-47
18434348-5	2008	GPR30 protein expression was studied by immunohistochemistry in paraffin-embedded sections.	Paraffin	64-72	G protein-coupled estrogen receptor 1	Homo sapiens	0-5
10778966-3	2000	TS enzyme levels were evaluated immunohistochemically using the specific monoclonal antibody TS 106 in paraffin-embedded tumors from 243 patients who had undergone primary surgery for rectal cancer during the years 1980-1993.	Paraffin	103-111	thymidylate synthetase	Homo sapiens	0-2
18572699-7	2008	AFM showed that the surface of conducting composite material-glucose oxidase electrode"s presents uniform granular after washing paraffin wax with cyclohexane, which was favorable for enzyme-catalyzed reaction.	Paraffin	129-141	hydroxyacid oxidase 1	Homo sapiens	61-76
10759946-3	2000	METHODS AND RESULTS: HSP27 expression was studied using immunohistochemistry on formalin-fixed, paraffin-embedded tissue sections from 21 oesophageal squamous cell carcinomas occurring in smokers and/or alcohol abusers.	Paraffin	96-104	heat shock protein family B (small) member 1	Homo sapiens	21-26
10821486-4	2000	Although normal mesothelium remains negative, NCAM was expressed in 19 of 26 MM (73%) with a membranous staining on frozen or paraffin sections.	Paraffin	126-134	neural cell adhesion molecule 1	Homo sapiens	46-50
18243944-4	2008	Spa therapies consist of a range of therapies including mud and paraffin-ozokerite applications; pearl baths; underwater shower-massage; manual massage; therapeutic exercises in the gym and in the swimming pool.	Paraffin	64-72	surfactant protein A2	Homo sapiens	0-3
17893871-10	2008	Of 25 paraffin-embedded tumors, 9 showed downregulation of PAR-4 protein and this downregulation of PAR-4 correlated significantly with K-ras mutational status (p &lt; 0.00002).	Paraffin	6-14	KRAS proto-oncogene, GTPase	Homo sapiens	136-141
10821495-3	2000	To determine the intratumor distribution and amount of thioredoxin protein in human primary carcinomas, we developed an immunohistochemical assay for thioredoxin in paraffin-embedded tissue.	Paraffin	165-173	thioredoxin	Homo sapiens	150-161
10821495-5	2000	To further relate thioredoxin protein overexpression to cell death and survival, we used a paraffin-based in situ end-labeling (ISEL) assay.	Paraffin	91-99	thioredoxin	Homo sapiens	18-29
10696455-1	2000	OBJECTIVE: To compare manual to image analysis estimation of proliferating cell nuclear antigen (PCNA) expression in paraffin sections of breast carcinomas.	Paraffin	117-125	proliferating cell nuclear antigen	Homo sapiens	61-95
18544998-3	2008	Using laser-captured microdissection and a real-time RT-PCR assay, we quantitatively evaluated mRNA levels of IGF-1R, EGFR and HER2 in paraffin-embedded cancer specimens of surgically removed primary tumors.	Paraffin	135-143	insulin like growth factor 1 receptor	Homo sapiens	110-116
17878253-7	2007	Paraffin-embedded sections of the growth plates were used to detect expression of the GPR30 protein.	Paraffin	0-8	G protein-coupled estrogen receptor 1	Homo sapiens	86-91
10696455-1	2000	OBJECTIVE: To compare manual to image analysis estimation of proliferating cell nuclear antigen (PCNA) expression in paraffin sections of breast carcinomas.	Paraffin	117-125	proliferating cell nuclear antigen	Homo sapiens	97-101
10696455-2	2000	STUDY DESIGN: Paraffin sections of 51 breast carcinomas were stained with primary antibody to PCNA.	Paraffin	14-22	proliferating cell nuclear antigen	Homo sapiens	94-98
10544213-7	1999	In rat tissues, ODC immunoreactivity was best preserved in paraffin sections fixed with Bouin"s fixative.	Paraffin	59-67	ornithine decarboxylase 1	Rattus norvegicus	16-19
17464313-4	2007	MIB1 was used to immunohistochemically visualise proliferating cells within formalin-fixed, paraffin-embedded, archival tissue sections of different vulvar premalignancies (N=48) and normal vulvar epithelium (N=16).	Paraffin	92-100	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-4
10448690-9	1999	At the MCC, routine use of CKI on paraffin sections of grossly negative SLNs enabled the upstaging of 10.6% of patients from N0 to N1.	Paraffin	34-42	choline kinase alpha	Homo sapiens	27-30
17656204-2	2007	METHODS: Immunohistochemical staining for livin was performed using paraffin-embedded tissues from 45 cases of RCC.	Paraffin	68-76	baculoviral IAP repeat containing 7	Homo sapiens	42-47
18069630-2	2007	METHODS: Methylation specific PCR (MSP) was used to examine the promoter methylation of tumor suppressor genes E-cadherin, hMLH1, APC and MGMT in paraffin-embedded gastric cancer tissue and adjacent normal foveolar epithelium in 106 cases.	Paraffin	146-154	O-6-methylguanine-DNA methyltransferase	Homo sapiens	138-142
10368636-2	1999	The aim of this study was to detect the protein expression pattern of hMSH2 and hMLH1 in oral squamous cell carcinoma (SCC) by immunohistochemistry in paraffin-embedded tissues.	Paraffin	151-159	mutL homolog 1	Homo sapiens	80-85
10368636-2	1999	The aim of this study was to detect the protein expression pattern of hMSH2 and hMLH1 in oral squamous cell carcinoma (SCC) by immunohistochemistry in paraffin-embedded tissues.	Paraffin	151-159	serpin family B member 3	Homo sapiens	119-122
17487855-4	2007	The immunohistochemistry of 111 paraffin-embedded CCA tissues showed that VDR expression gradually increased during CCA development.	Paraffin	32-40	vitamin D receptor	Homo sapiens	74-77
10217560-6	1999	In both cases, a reverse transcription-polymerase chain reaction using RNA extracted from formalin-fixed, paraffin-embedded tissues detected SYT-SSX fusion gene transcripts, which are characteristic of synovial sarcoma.	Paraffin	106-114	SSX family member 2B	Homo sapiens	145-148
11829814-5	1999	Dynamic changes of proliferating cell nuclear antigen (PCNA) expression were studied by immunohistochemistry on paraffin-embedded sections.	Paraffin	112-120	proliferating cell nuclear antigen	Homo sapiens	55-59
17412867-5	2007	METHODS: NGAL expression in 81 paraffin sections, including ESCC, normal mucosa, simple hyperplasia and dysplasia, and in 73 fresh specimens of ESCC was analysed by immunohistochemistry, western blot and gelatin zymography.	Paraffin	31-39	lipocalin 2	Homo sapiens	9-13
17445277-11	2007	Moreover, when tyrosinase and melan-A are used together, 100% of the formalin-fixed, paraffin-embedded uveal melanoma samples tested positive for one of those markers.	Paraffin	85-93	tyrosinase	Homo sapiens	15-25
9892418-5	1999	Immunohistochemistry (IH), double immunofluorescence microscopy (DIF), and immunoelectron microscopy (IEM) were used to study the differential distribution of VEGF in paraffin-embedded (IH, DIF) and in cryo-substituted, Lowicryl-embedded (IEM) specimens of normal rat and human lungs and fibrotic rat lungs.	Paraffin	167-175	vascular endothelial growth factor A	Rattus norvegicus	159-163
10392297-5	1999	Immunoperoxidase stains on paraffin sections showed staining of the cells for anti-vimentin, but there was no staining for anti-keratin, anti-S-100 protein, anti-desmin, anti-glial fibrillary acidic protein (GFAP), or anti-actin.	Paraffin	27-35	vimentin	Homo sapiens	83-91
17650424-2	2007	METHODS: Methylation specific PCR (MSP) technique was used to examine the promoter methylation of 4 tumor suppressor genes (E-cadherin, hMLH1, APC, and MGMT) in 106 paraffin-embedded specimens of GAC, including tumor tissues and adjacent GFE, and 16 paraffin-embedded specimens of GFE of chronic gastritis.	Paraffin	165-173	O-6-methylguanine-DNA methyltransferase	Homo sapiens	152-156
9824606-11	1998	Antibodies which are effective in formalin fixed, paraffin wax embedded sections are useful for the identification of MMPs and TIMPs in diagnostic specimens.	Paraffin	50-62	matrix metallopeptidase 1	Homo sapiens	118-122
17295648-7	2007	Reverse transcription-polymerase chain reaction (RT-PCR) assay using formalin-fixed, paraffin-embedded tissue detected FUS-CREB3L2 fusion transcripts.	Paraffin	85-93	cAMP responsive element binding protein 3 like 2	Homo sapiens	123-130
9741148-1	1998	This report describes the immunohistochemical detection of the Ki-67 proliferation associated nuclear epitope by means of the MIB-1 monoclonal antibody (mAb) in paraffin tissue sections from nine samples of 16 tissues obtained from nine dogs.	Paraffin	161-169	MIB E3 ubiquitin protein ligase 1	Canis lupus familiaris	126-131
16924126-3	2006	We used immunohistochemistry to analyze CEACAM1 expression in formalin-fixed, paraffin-embedded cervical tissues from 15 healthy women, 15 patients with low-grade squamous intraepithelial lesions (SIL), 15 patients with high-grade SIL, and 15 patients with squamous carcinomas.	Paraffin	78-86	CEA cell adhesion molecule 1	Homo sapiens	40-47
9850335-2	1998	METHODS: Immunohistochemistry for p53, Bcl-2, and proliferating cell nuclear cell antigen (PCNA) proteins was performed, using a variety of monoclonal antibodies, on paraffin was embedded sections of tissues from 68 human embryos and fetuses of between 4 and 30 weeks gestation.	Paraffin	166-174	proliferating cell nuclear antigen	Homo sapiens	91-95
17080715-0	2006	Quantitative mRNA expression analysis of neurotrophin-receptor TrkC and oncogene c-MYC from formalin-fixed, paraffin-embedded primitive neuroectodermal tumor samples.	Paraffin	108-116	brain derived neurotrophic factor	Homo sapiens	41-53
16931951-0	2006	Molecular detection of FUS-CREB3L2 fusion transcripts in low-grade fibromyxoid sarcoma using formalin-fixed, paraffin-embedded tissue specimens.	Paraffin	109-117	cAMP responsive element binding protein 3 like 2	Homo sapiens	27-34
16931951-4	2006	In the present study, we conducted a reverse transcription-polymerase chain reaction assay to detect the FUS-CREB3L2 fusion transcripts using formalin-fixed, paraffin-embedded tumor tissue specimens from 16 LGFMSs including 3 cases with giant collagen rosettes.	Paraffin	158-166	cAMP responsive element binding protein 3 like 2	Homo sapiens	109-116
9563568-1	1998	To examine which proteins are responsible for the elevated protein tyrosine kinase (PTK) activity in human head and neck squamous cell carcinoma (HNSCC) and adjacent histologically normal epithelium, paraffin embedded sections of these tissues were stained for PTK c-Src.	Paraffin	200-208	protein tyrosine kinase 2 beta	Homo sapiens	84-87
16780589-4	2006	The expression of SCF receptor Kit was assessed using immunostaining of paraffin-embedded bronchial sections.	Paraffin	72-80	KIT ligand	Homo sapiens	18-21
9624390-1	1998	The expression of proliferating cell nuclear antigen in paraffin sections from 154 cases of laryngeal squamous cell carcinoma were examined.	Paraffin	56-64	proliferating cell nuclear antigen	Homo sapiens	18-52
16684601-3	2006	We have identified a novel heterozygous Leu1793Pro mutation in MYH7 in DNA from paraffin sections of one of the original siblings.	Paraffin	80-88	myosin heavy chain 7	Homo sapiens	63-67
9624390-8	1998	Nevertheless it appears that the immunohistological examination of PCNA in paraffin section could be a complementary prognostic tool for laryngeal carcinoma.	Paraffin	75-83	proliferating cell nuclear antigen	Homo sapiens	67-71
16541017-4	2006	CXCR1 was localized in 81 formalin-fixed, paraffin-embedded renal specimens by immunohistochemistry using a monoclonal antibody against human CXCR1.	Paraffin	42-50	C-X-C motif chemokine receptor 1	Homo sapiens	0-5
9610028-1	1998	The expressions of p53 and proliferating cell nuclear antigen (PCNA) were studied immunohistochemically from paraffin sections of 7 cases (9 lesions) of radiation-induced colon cancer and 42 cases of spontaneous colon cancer.	Paraffin	109-117	proliferating cell nuclear antigen	Homo sapiens	63-67
16187283-6	2006	GABRP downregulation in breast cancer was confirmed by quantitative RT-PCR in cryopreserved breast tumour and normal breast tissue specimens (n = 22), in archival formalin-fixed, paraffin-embedded tissue specimens (n = 32), as well as in breast cancer cell lines (n = 8).	Paraffin	179-187	gamma-aminobutyric acid type A receptor subunit pi	Homo sapiens	0-5
9615189-0	1998	Detection of CD5 antigen on B cell lymphomas in fixed, paraffin embedded tissues using signal amplification by catalyzed reporter deposition.	Paraffin	55-63	CD5 molecule	Homo sapiens	13-16
16523412-4	2006	Tissue expression of adrenomedullin was studied using monoclonal antibodies on pretreated paraffin embedded tissues in a group of 31 patients.	Paraffin	90-98	adrenomedullin	Homo sapiens	21-35
9615189-3	1998	However, conflicting results have been reported with regard to the detection of CD5 antigen expression on B cell non-Hodgkin"s lymphomas (B-NHLs) in fixed, paraffin embedded tissues using routine immunohistochemical (IHC) staining techniques.	Paraffin	156-164	CD5 molecule	Homo sapiens	80-83
9615190-7	1998	In conclusion, paraffin embedded and formalin fixed PC needle biopsies exhibit a higher diagnostic PCNA/Cyclin than Ki-67/MIB1 index for cases presenting differentiated features, whereas p120 nucleolar protein detection seems to be a suitable marker of poorer outcome of PC.	Paraffin	15-23	proliferating cell nuclear antigen	Homo sapiens	99-103
9615190-7	1998	In conclusion, paraffin embedded and formalin fixed PC needle biopsies exhibit a higher diagnostic PCNA/Cyclin than Ki-67/MIB1 index for cases presenting differentiated features, whereas p120 nucleolar protein detection seems to be a suitable marker of poorer outcome of PC.	Paraffin	15-23	proliferating cell nuclear antigen	Homo sapiens	104-110
11315957-1	1998	The estrogen receptor (ER) was visualized immunohistochemically in paraffin sections of the canine uterus using a monoclonal antibody.	Paraffin	67-75	estrogen receptor 1	Canis lupus familiaris	4-21
16007506-6	2006	We have used laser confocal microscopy of paraffin-embedded murine tissue sections to provide the first detailed characterization of the distribution of inversin in various organs.	Paraffin	42-50	inversin	Mus musculus	153-161
11315957-1	1998	The estrogen receptor (ER) was visualized immunohistochemically in paraffin sections of the canine uterus using a monoclonal antibody.	Paraffin	67-75	estrogen receptor 1	Canis lupus familiaris	23-25
17033167-4	2006	Paraffin-embedded tissues were stained with H11 antibody.	Paraffin	0-8	H1.1 linker histone, cluster member	Homo sapiens	44-47
9651945-6	1998	Using Flow Cytometry, we analysed the DNA ploidy pattern of 37 paraffin-embedded PRCC.	Paraffin	63-71	proline rich mitotic checkpoint control factor	Homo sapiens	81-85
10921065-2	1998	METHODS: Monoclonal antibody PC10 was used to stain PCNA in archival paraffin-embedded tissues.	Paraffin	69-77	proliferating cell nuclear antigen	Homo sapiens	52-56
16416732-2	2005	We conducted this study to fully characterize mesothelin expression in surgically resected, formalin-fixed, paraffin-embedded tissue specimens of 18 pancreatic adenocarcinomas, 9 adenocarcinomas of the ampulla of Vater, 12 adenocarcinomas of the common bile duct, and 17 cases of chronic pancreatitis.	Paraffin	108-116	mesothelin	Homo sapiens	46-56
9470819-8	1997	It is concluded that TS immunostaining intensity reflects TS enzyme activity in colorectal tumours and is well suited for paraffin-embedded material.	Paraffin	122-130	thymidylate synthetase	Homo sapiens	21-23
16044160-3	2005	The aims of the study was to confirm the frequency of KLF6 mutations in a larger series of CRC than that previously published by using DNA extracted from frozen tissue samples, which have been proved to generate less mutational artefact than that extracted from formalin-fixed paraffin-embedded tissue samples, in order to compare KLF6 mutation frequency with that of other common genetic alterations and to determine genotype-phenotype correlations.	Paraffin	277-285	Kruppel like factor 6	Homo sapiens	54-58
9310947-1	1997	We used a new antibody (NCL-CD5-4C7) immunoreactive for CD5-positive cells in paraffin-embedded tissue, with the microwave antigen retrieval method, to analyze a number of well-characterized cases of B-cell and T-cell non-Hodgkin"s lymphomas whose CD5 immunoreactivity was documented by immunohistochemical analysis performed on frozen sections and/or flow cytometric immunophenotypic analysis of neoplastic cell suspensions.	Paraffin	78-86	CD5 molecule	Homo sapiens	28-31
9310947-1	1997	We used a new antibody (NCL-CD5-4C7) immunoreactive for CD5-positive cells in paraffin-embedded tissue, with the microwave antigen retrieval method, to analyze a number of well-characterized cases of B-cell and T-cell non-Hodgkin"s lymphomas whose CD5 immunoreactivity was documented by immunohistochemical analysis performed on frozen sections and/or flow cytometric immunophenotypic analysis of neoplastic cell suspensions.	Paraffin	78-86	CD5 molecule	Homo sapiens	56-59
9310947-1	1997	We used a new antibody (NCL-CD5-4C7) immunoreactive for CD5-positive cells in paraffin-embedded tissue, with the microwave antigen retrieval method, to analyze a number of well-characterized cases of B-cell and T-cell non-Hodgkin"s lymphomas whose CD5 immunoreactivity was documented by immunohistochemical analysis performed on frozen sections and/or flow cytometric immunophenotypic analysis of neoplastic cell suspensions.	Paraffin	78-86	CD5 molecule	Homo sapiens	56-59
9310947-3	1997	All CD5-positive T-cell non-Hodgkin"s lymphomas (13 [100%] of 13) from several histologic subgroups, were immunoreactive for CD5 in paraffin sections, although 4 of 13 exhibited weak or limited staining of neoplastic cells.	Paraffin	132-140	CD5 molecule	Homo sapiens	4-7
16200333-10	2005	MATERIALS AND METHODS: We investigated the immunohistochemical expression of CD30 antigen in 15 paraffin-embedded tissue samples representing epidermis and epidermal buds from foetuses after spontaneous abortion in 8th, 10th, and 12th week of gestation, respectively, using the monoclonal antibody Ki-1.	Paraffin	96-104	TNF receptor superfamily member 8	Homo sapiens	77-81
9310947-3	1997	All CD5-positive T-cell non-Hodgkin"s lymphomas (13 [100%] of 13) from several histologic subgroups, were immunoreactive for CD5 in paraffin sections, although 4 of 13 exhibited weak or limited staining of neoplastic cells.	Paraffin	132-140	CD5 molecule	Homo sapiens	125-128
16157025-16	2005	CONCLUSIONS: Molecular detection of EWS-Fli1 fusion transcripts in formalin-fixed paraffin-embedded material by nested RT-PCR is feasible and is useful for the diagnosis and differential diagnosis of ES/pPNETs.	Paraffin	82-90	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	40-44
9310947-6	1997	CD5 antibody NCL-CD5-4C7 should be useful for the routine characterization of suspected T-cell and B-cell lymphoproliferative disorders when only paraffin-embedded tissue is available for immunophenotypic analysis.	Paraffin	146-154	CD5 molecule	Homo sapiens	0-3
9310947-6	1997	CD5 antibody NCL-CD5-4C7 should be useful for the routine characterization of suspected T-cell and B-cell lymphoproliferative disorders when only paraffin-embedded tissue is available for immunophenotypic analysis.	Paraffin	146-154	CD5 molecule	Homo sapiens	17-20
9270000-6	1997	The possibility of a simple assay, such as the immunohistochemical analysis of p27 expression on routinely formalin-fixed, paraffin-embedded specimens, has considerable value for the prognosis of patients who undergo surgical resection.	Paraffin	123-131	interferon alpha inducible protein 27	Homo sapiens	79-82
16191370-2	2005	METHODS: RANKL and OPG were detected by immunohistochemistry (SP) in 24 paraffin-embedded and 2 frozen specimens of central giant cell lesion of jaw.	Paraffin	72-80	TNF superfamily member 11	Homo sapiens	9-14
9252683-6	1997	In the present immunocytochemical study, PSA expression was examined employing a biotin-streptavidin based, alkaline phosphatase conjugated antigen detection technique in 16 routine, neutral formalin fixed, paraffin-wax embedded, primary BC tissue sections.	Paraffin	207-219	kallikrein related peptidase 3	Homo sapiens	41-44
9262059-4	1997	Autopsy did not reveal the cause of death of the stillborn infant, who was also found to be affected with MEN 2A by molecular study of paraffin-embedded tissue.	Paraffin	135-143	ret proto-oncogene	Homo sapiens	106-112
15872055-4	2005	BRCA1 gene expression in archival paraffin-embedded breast cancer tissues was studied simultaneously at the protein and mRNA levels, and the two findings were compared.	Paraffin	34-42	BRCA1 DNA repair associated	Homo sapiens	0-5
9349230-2	1997	The present study of the polymerase chain reaction (PCR) as a diagnostic tool in early mycosis fungoides was therefore undertaken, using a rapid PCR method for the detection of gamma- and beta-chain T-cell receptor (TCR) gene rearrangements in routine formalin-fixed, paraffin-embedded histological sections.	Paraffin	268-276	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	216-219
15819958-2	2005	Paraffin sections of healthy follicles and various stages of atretic follicles were stained using the terminal deoxynucleotidyl transferase (TdT)-mediated biotinylated deoxyuridine triphosphates (dUTP) nick end-labelling (TUNEL) method to detect DNA fragmentation and cleaved caspase-3 antibody to detect cells committed to undergo apoptosis.	Paraffin	0-8	DNA nucleotidylexotransferase	Bos taurus	102-139
15819958-2	2005	Paraffin sections of healthy follicles and various stages of atretic follicles were stained using the terminal deoxynucleotidyl transferase (TdT)-mediated biotinylated deoxyuridine triphosphates (dUTP) nick end-labelling (TUNEL) method to detect DNA fragmentation and cleaved caspase-3 antibody to detect cells committed to undergo apoptosis.	Paraffin	0-8	DNA nucleotidylexotransferase	Bos taurus	141-144
9139707-7	1997	Immunohistochemical staining of formalin-fixed paraffin-embedded rat heart tissue sections using the anti-CYP2J2 IgG and avidin-biotin-peroxidase detection localized expression of CYP2J3 primarily to atrial and ventricular myocytes.	Paraffin	47-55	cytochrome P450, family 2, subfamily j, polypeptide 3	Rattus norvegicus	180-186
15644135-4	2005	RESULTS: We investigated the immunohistochemical expression of CD30 antigen in 15 paraffin-embedded tissue samples representing small intestines from fetuses after spontaneous abortion in the 8th, 10th and 12th weeks using the monoclonal antibody Ki-1.	Paraffin	82-90	TNF receptor superfamily member 8	Homo sapiens	63-67
23045122-7	2005	Since the methods amplify relatively small segments of NAT1 or NAT2, they are effective for human DNA samples derived from buccal cells or paraffin-embedded tissues.	Paraffin	139-147	N-acetyltransferase 2	Homo sapiens	63-67
15660650-8	2005	Both CD62L and CD7 in paraffin-embedded, formalin-fixed tissue are useful diagnostic adjuncts, especially in regard to the discrimination of lymphomatoid hypersensitivity reactions from true endogenous T-cell dyscrasia.	Paraffin	22-30	CD7 molecule	Homo sapiens	15-18
9124220-0	1997	CD5 immunostaining of lymphoid neoplasms in paraffin sections.	Paraffin	44-52	CD5 molecule	Homo sapiens	0-3
9124221-0	1997	CD5 immunostaining of lymphoid neoplasms in paraffin sections.	Paraffin	44-52	CD5 molecule	Homo sapiens	0-3
9110288-2	1997	O13, a monoclonal antibody that recognizes CD99, the p30/32MIC2 gene product, has been used to identify a number of cell types, including lymphoblasts, in paraffin sections.	Paraffin	155-163	immunoglobulin kappa variable 2-38 (pseudogene)	Homo sapiens	0-3
15619214-3	2004	IGF-1R expression was evaluated in formalin-fixed, paraffin-embedded tissue of 210 primary breast cancer patients by using anti-IGF-1R antibody.	Paraffin	51-59	insulin like growth factor 1 receptor	Homo sapiens	0-6
15491976-0	2004	CD163: a specific marker of macrophages in paraffin-embedded tissue samples.	Paraffin	43-51	CD163 molecule	Homo sapiens	0-5
15491976-1	2004	Paraffin-section immunohistochemical analysis was performed using a monoclonal antibody against CD163 to evaluate the antibody"s usefulness in identifying cells of monocyte/macrophage lineage in normal and neoplastic conditions.	Paraffin	0-8	CD163 molecule	Homo sapiens	96-101
9125025-5	1997	INTERVENTION: The PCNA-labeling index [(PCNA-positive cells/1000 cells) x 100] was quantified in paraffin-embedded tissue specimens from 123 patients with lymph node-positive primary breast cancer by immunohistochemical staining.	Paraffin	97-105	proliferating cell nuclear antigen	Homo sapiens	18-22
15486895-5	2004	Expression of CXCR4 (12g5 antibody) was evaluated on formalin-fixed paraffin-embedded tumor tissues using standard immunohistochemical techniques.	Paraffin	68-76	C-X-C motif chemokine receptor 4	Homo sapiens	14-19
9179692-2	1997	MATERIALS AND METHODS: The immunohistochemical status of the PCNA and p53 proteins were determined on paraffin-embedded sections from 128 patients with TCC of the urinary bladder, using PC-10 and DO7 as the primary antibodies.	Paraffin	102-110	proliferating cell nuclear antigen	Homo sapiens	61-65
15234568-2	2004	We performed TdT-mediated dUTP-nick end labelling (TUNEL) staining of paraffin embedded bone marrow specimens to assess the amount of apoptotic cells in 21 MDS patients (7 RA, 3 RARS, 5 RAEB, 3 RAEB-T, 3 CMML) and five normal controls.	Paraffin	70-78	DNA nucleotidylexotransferase	Homo sapiens	13-16
9147067-0	1997	A novel monoclonal antibody, RM-4, specifically recognizes rat macrophages and dendritic cells in formalin-fixed, paraffin-embedded tissues.	Paraffin	114-122	DNA-damage inducible transcript 3	Rattus norvegicus	29-33
15349122-3	2004	METHODS: RKIP expression in normal pancreas and human insulinomas was examined by using paraffin-embedded sections.	Paraffin	88-96	phosphatidylethanolamine binding protein 1	Homo sapiens	9-13
15363317-0	2004	[Detection of EWS-FLI1 fusion transcript in Ewing"s sarcoma/peripheral primitive neuroectodermal tumors by one-step RT-PCR using paraffin-embedded tissues].	Paraffin	129-137	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	18-22
15363317-1	2004	OBJECTIVE: To investigate the expression of EWS-FLI1/ERG fusion transcript resulting from t(11;12)(q24;12) in paraffin-embedded tissues and its diagnostic implication for Ewing"s sarcoma/peripheral primitive neuroectodermal tumors (ES/pPNET).	Paraffin	110-118	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	48-52
9147067-5	1997	The immunoreactivity of RM-4 was well preserved not only in frozen sections but also in formalin-fixed, paraffin-embedded tissues.	Paraffin	104-112	DNA-damage inducible transcript 3	Rattus norvegicus	24-28
9147067-11	1997	RM-4 is considered to be a useful tool not only for identifying macrophage/dendritic cells both in frozen and paraffin-embedded tissues, but also for evaluating their endolysosomal processing.	Paraffin	110-118	DNA-damage inducible transcript 3	Rattus norvegicus	0-4
9066620-3	1997	The proliferative activity was investigated by measuring the PCNA expression in paraffin embedded tissue sections.	Paraffin	80-88	proliferating cell nuclear antigen	Homo sapiens	61-65
15144342-6	2004	FAS expression was determined using immunohistochemical methods in formalin-fixed and paraffin-embedded cancer specimens.	Paraffin	86-94	fatty acid synthase	Homo sapiens	0-3
9184181-2	1997	Our aim was to localize PSA immunohistochemically in a selected group of 27 paraffin-embedded breast tissues.	Paraffin	76-84	kallikrein related peptidase 3	Homo sapiens	24-27
15073847-5	2004	The expression of Cks1 was also examined by immunohistochemistry using formalin-fixed, paraffin-embedded tissue sections from the same patients.	Paraffin	87-95	CDC28 protein kinase regulatory subunit 1B pseudogene 7	Homo sapiens	18-22
8952536-5	1996	As the PG-M3 epitope is partially resistant to fixatives, only cells that overexpress PML are detected by the antibody in microwave-heated paraffin sections.	Paraffin	139-147	phosphoglucomutase 3	Homo sapiens	7-12
8952536-5	1996	As the PG-M3 epitope is partially resistant to fixatives, only cells that overexpress PML are detected by the antibody in microwave-heated paraffin sections.	Paraffin	139-147	PML nuclear body scaffold	Homo sapiens	86-89
9025899-4	1996	We studied the expression of the H19 gene by in-situ hybridization performed on paraffin sections of the kidney.	Paraffin	80-88	H19 imprinted maternally expressed transcript	Homo sapiens	33-36
8816596-3	1996	Recently, a new monoclonal antibody to CD5, NCL-CD5, has been introduced that detects CD5 in paraffin-embedded tissues.	Paraffin	93-101	CD5 molecule	Homo sapiens	39-42
8816596-3	1996	Recently, a new monoclonal antibody to CD5, NCL-CD5, has been introduced that detects CD5 in paraffin-embedded tissues.	Paraffin	93-101	CD5 molecule	Homo sapiens	48-51
8816596-3	1996	Recently, a new monoclonal antibody to CD5, NCL-CD5, has been introduced that detects CD5 in paraffin-embedded tissues.	Paraffin	93-101	CD5 molecule	Homo sapiens	48-51
8816596-9	1996	The three CD5- malignancies were also negative in paraffin sections (P = .001; McNemar test).	Paraffin	50-58	CD5 molecule	Homo sapiens	10-13
8816596-12	1996	Although NCL-CD5 does indeed stain reactive T cells in paraffin sections, it does not appear to stain neoplastic CD5+ cells.	Paraffin	55-63	CD5 molecule	Homo sapiens	13-16
9346673-3	1996	The intrahepatic expression of proliferating cell nuclear antigen on paraffin-embedded liver biopsy specimens (n = 110 from 32 patients) was examined by an avidin-biotin peroxidase method using a monoclonal antibody to proliferating cell nuclear antigen.	Paraffin	69-77	proliferating cell nuclear antigen	Homo sapiens	31-65
8844316-6	1996	Transforming growth factor-alpha (TGF alpha), epidermal growth factor (EGF), and epidermal growth factor receptor (EGFR) were immunolocalized in the paraffin-embedded sections of the uteri at 0600 hr on day 5 pc.	Paraffin	149-157	epidermal growth factor receptor	Mus musculus	115-119
8706258-8	1996	Exons 1 and 2 of the Ki-ras gene were amplified from paraffin-embedded tissue samples.	Paraffin	53-61	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	21-27
8623936-1	1996	Anti-Mullerian hormone (AMH) immunoreactivity was studied on paraffin sections obtained from archival testicular biopsies of 29 children with intersex disorders and of 22 controls.	Paraffin	61-69	anti-Mullerian hormone	Homo sapiens	24-27
8762873-0	1996	Immunohistochemical expression of Epstein-Barr virus-encoded latent membrane protein (LMP-1) in paraffin sections of EBV-associated nasopharyngeal carcinoma in Spanish patients.	Paraffin	96-104	LMP1	Human gammaherpesvirus 4	86-91
8929865-4	1996	The streptavidin-biotin immunoperoxidase method, applied to paraffin-embedded specimens from 39 fetuses ranging from 10 to 41 wk, showed that TGF-alpha, EGF, and EGF receptor exhibited a similar cellular distribution during the whole period of gestation.	Paraffin	60-68	epidermal growth factor	Homo sapiens	153-156
8929865-4	1996	The streptavidin-biotin immunoperoxidase method, applied to paraffin-embedded specimens from 39 fetuses ranging from 10 to 41 wk, showed that TGF-alpha, EGF, and EGF receptor exhibited a similar cellular distribution during the whole period of gestation.	Paraffin	60-68	epidermal growth factor	Homo sapiens	162-165
9106385-3	1996	Immunohistochemical phenotypization carried out on paraffin-embedded section revealed that most cells in the neurosphere expressed high levels of vimentin that is normally found in immature neural cells.	Paraffin	51-59	vimentin	Homo sapiens	146-154
8714262-0	1996	Proliferating cell nuclear antigen (PCNA) in non-Hodgkin"s lymphomas: correlation with working formulation and Kiel classification in formalin-fixed paraffin-embedded material.	Paraffin	149-157	proliferating cell nuclear antigen	Homo sapiens	0-34
8714262-0	1996	Proliferating cell nuclear antigen (PCNA) in non-Hodgkin"s lymphomas: correlation with working formulation and Kiel classification in formalin-fixed paraffin-embedded material.	Paraffin	149-157	proliferating cell nuclear antigen	Homo sapiens	36-40
8714262-3	1996	This study documents the detection of PCNA, using antibody PC 10 in formalin-fixed, paraffin-embedded tissue, and correlates the proliferative activity of the non-Hodgkin"s lymphomas (NHL) with histological grading assessed by the International Working Formulation (WF) and Kiel classification.	Paraffin	84-92	proliferating cell nuclear antigen	Homo sapiens	38-42
7497450-2	1995	Immunohistochemically, the paraffin-embedded tumor tissue displayed positive vimentin reactivity and lack of cytokeratin expression, indicating a mesenchymal origin.	Paraffin	27-35	vimentin	Homo sapiens	77-85
8552575-5	1995	In paraffin-embedded skin, matrical and outer sheath epithelium of vellus anagen follicles, inferior segment epithelium of vellus telogen follicles, and secretory coils of sweat glands stain with Ber-EP4, but anagen terminal follicle epithelium and eccrine and apocrine sweat ducts are negative.	Paraffin	3-11	prostaglandin E receptor 4	Homo sapiens	200-203
7653697-3	1995	METHOD: Activation of the CRH neurons was determined through measurement of the amount of CRH-mRNA in the paraventricular nucleus by using quantitative, in situ hybridization histochemistry with systematically sampled frontal sections through the hypothalamus of routinely formalin-fixed and paraffin-embedded autopsy brain material of 10 comparison subjects, 10 patients with Alzheimer"s disease, and seven depressed patients.	Paraffin	292-300	corticotropin releasing hormone	Homo sapiens	26-29
8530693-4	1995	Immunoreactive IL-1ra was found in both cryostat and paraffin-embedded sections of human endometrium using the alkaline phosphatase-peroxidase (A-P) method with two different IL-1ra antibodies.	Paraffin	53-61	interleukin 1 receptor antagonist	Homo sapiens	15-21
7781791-1	1995	A three-step immunoperoxidase staining technique was used in order to estimate the immunohistochemical expression of K-ras, c-fos, c-myc and c-erbB-2 oncoproteins, in paraffin sections of 20 patients, with histologically proven adenocarcinoma of the pancreas.	Paraffin	167-175	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	131-136
7595826-2	1995	In this study, PCNA was identified immunohistochemically using paraffin section in 67 human neuroblastomas.	Paraffin	63-71	proliferating cell nuclear antigen	Homo sapiens	15-19
7887778-5	1995	DESIGN: Anti-IL-1ra monoclonal antibody was applied to paraffin sections of Hodgkin"s disease and non-Hodgkin"s lymphoma (NHL) with avidin-biotin complex method.	Paraffin	55-63	interleukin 1 receptor antagonist	Homo sapiens	13-19
7841053-3	1995	The monoclonal antibody PC10 stains PCNA in archival paraffin-embedded tissue.	Paraffin	53-61	proliferating cell nuclear antigen	Homo sapiens	36-40
7855987-6	1995	METHODS: In situ hybridization for H19 mRNA on paraffin sections of bladder carcinoma in different histologic grades.	Paraffin	47-55	H19 imprinted maternally expressed transcript	Homo sapiens	35-38
7821917-1	1995	An immunohistochemical study of 15 ovarian formalin-fixed, paraffin-embedded dysgerminomas showed positive staining of tumor cells for vimentin in all cases.	Paraffin	59-67	vimentin	Homo sapiens	135-143
21597698-1	1995	Overexpression of PCNA (more than 25% positive tumour cells) and positivity of c-erbB-2 oncoprotein were immunohistochemically demonstrated in 490 formalin-fixed and paraffin-embedded breast carcinomas.	Paraffin	166-174	proliferating cell nuclear antigen	Homo sapiens	18-22
7725609-0	1995	Assessment of proliferative activity by anti-PCNA monoclonal antibodies in formalin-fixed, paraffin-embedded samples and correlation with mitotic index.	Paraffin	91-99	proliferating cell nuclear antigen	Homo sapiens	45-49
7874614-1	1994	The PC10, a monoclonal antibody against proliferating cell nuclear antigen (PCNA), is known to show immunoreactivity in routinely processed paraffin embedded tissue.	Paraffin	140-148	proliferating cell nuclear antigen	Homo sapiens	40-74
15100734-3	2004	Immunohistochemical technique for MAGE-3 antigen was performed using formal infixed paraffin embedded section of 121 renal and urinary bladder tumor specimens.	Paraffin	84-92	MAGE family member A3	Homo sapiens	34-48
7874614-1	1994	The PC10, a monoclonal antibody against proliferating cell nuclear antigen (PCNA), is known to show immunoreactivity in routinely processed paraffin embedded tissue.	Paraffin	140-148	proliferating cell nuclear antigen	Homo sapiens	76-80
7524464-0	1994	Detection of proliferating cell nuclear antigen in paraffin-embedded specimens is dependent on preembedding tissue handling and fixation.	Paraffin	51-59	proliferating cell nuclear antigen	Homo sapiens	13-47
14984576-0	2004	HSP47 is a useful marker for skin fibroblasts in formalin-fixed, paraffin-embedded tissue specimens.	Paraffin	65-73	serpin family H member 1	Homo sapiens	0-5
14984576-1	2004	AIM: This study was undertaken to assess whether heat-shock protein (HSP)47 is a useful cell marker for skin fibroblasts in formalin-fixed, paraffin-embedded skin specimens.	Paraffin	140-148	serpin family H member 1	Homo sapiens	69-75
14984576-5	2004	RESULTS: Immunostaining for HSP47 clearly detected skin fibroblasts in paraffin tissue sections as well as in fibroblast cultures and frozen tissue sections.	Paraffin	71-79	serpin family H member 1	Homo sapiens	28-33
14984576-6	2004	HSP47 staining on paraffin sections from diseased skin specimens revealed that skin ulcer, keloid, nodular fascitis, spindle cell lipoma, and dermatofibroma had strong signals for HSP47 compared with the signals obtained from normal skin.	Paraffin	18-26	serpin family H member 1	Homo sapiens	0-5
8078299-4	1994	EXPERIMENTAL DESIGN: By use of antibodies specific to peripherin and NF-66/alpha-internexin, we detected these proteins on Western blots of NB tissue extracts and in paraffin sections of NBs.	Paraffin	166-174	peripherin	Homo sapiens	54-64
14984576-11	2004	CONCLUSIONS: These findings indicate that HSP47 staining can detect skin fibroblasts in routine, paraffin-embedded specimens.	Paraffin	97-105	serpin family H member 1	Homo sapiens	42-47
14984576-12	2004	A panel approach using HSP47 and other cell markers on paraffin sections may help the identification of the cell type involved with mesenchymal proliferative disorders.	Paraffin	55-63	serpin family H member 1	Homo sapiens	23-28
14871971-3	2004	EXPERIMENTAL DESIGN: Unstained sections of paraffin-embedded tumor samples were stained with p185/HER2 receptor antibody.	Paraffin	43-51	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	93-97
14991539-5	2004	We conclude that the in situ hybridization assay for the detection of Ku70 and Ku80 expression used in this study is also suitable for tissue microarray analysis of paraffin-embedded melanoma samples.	Paraffin	165-173	X-ray repair cross complementing 6	Homo sapiens	70-74
7960944-0	1994	Immunohistochemical detection of tissue factor (TF) on paraffin sections of routinely fixed human tissue.	Paraffin	55-63	coagulation factor III, tissue factor	Homo sapiens	33-46
7960944-0	1994	Immunohistochemical detection of tissue factor (TF) on paraffin sections of routinely fixed human tissue.	Paraffin	55-63	coagulation factor III, tissue factor	Homo sapiens	48-50
7960944-4	1994	Here, we demonstrate a method using monoclonal anti-TF antibodies to detect TF in routinely fixed, microwaved, paraffin-embedded tissues.	Paraffin	111-119	coagulation factor III, tissue factor	Homo sapiens	52-54
7960944-4	1994	Here, we demonstrate a method using monoclonal anti-TF antibodies to detect TF in routinely fixed, microwaved, paraffin-embedded tissues.	Paraffin	111-119	coagulation factor III, tissue factor	Homo sapiens	76-78
7960944-6	1994	However, in most cases, the paraffin sections allow a better cellular localization of TF.	Paraffin	28-36	coagulation factor III, tissue factor	Homo sapiens	86-88
7960944-8	1994	The paraffin-embedded material, however, clearly shows that TF expression is restricted to the parietal and the visceral epithelia of Bowman"s capsule of glomeruli in the kidney, and to astrocytes and their processes in the brain.	Paraffin	4-12	coagulation factor III, tissue factor	Homo sapiens	60-62
7960944-10	1994	The immunohistological detection of TF in paraffin sections is a powerful tool for systematic studies on the possible role of TF in the context of physiological and pathological studies.	Paraffin	42-50	coagulation factor III, tissue factor	Homo sapiens	36-38
7937596-2	1994	The proliferative activity of the trophoblast was determined using an antibody against proliferating cell nuclear antigen (PCNA) which stains all proliferating cells in paraffin-embedded tissues.	Paraffin	169-177	proliferating cell nuclear antigen	Homo sapiens	87-121
14678388-4	2004	CD44 expression was measured by immunohistochemical analysis of paraffin-embedded tissue obtained from these patients after appropriate treatment (transurethral resection, partial or radical cystectomy).	Paraffin	64-72	CD44 molecule (Indian blood group)	Homo sapiens	0-4
14654370-9	2003	Paraffin-embedded tissue sections were used for immunohistochemical analysis of HO-1 and HO-2.	Paraffin	0-8	heme oxygenase 1	Rattus norvegicus	80-93
7937596-2	1994	The proliferative activity of the trophoblast was determined using an antibody against proliferating cell nuclear antigen (PCNA) which stains all proliferating cells in paraffin-embedded tissues.	Paraffin	169-177	proliferating cell nuclear antigen	Homo sapiens	123-127
8579131-5	1994	The advantage of using PCNA is that standard archival formalin-fixed, paraffin-embedded tissues may be analyzed and that PCNA detect cells in G1 through S phase, allowing S-phase fractions, determined by flow cytometry.	Paraffin	70-78	proliferating cell nuclear antigen	Homo sapiens	23-27
14623482-0	2003	Exposure of babies to C15-C45 mineral paraffins from human milk and breast salves.	Paraffin	38-47	placenta associated 8	Homo sapiens	22-25
7515286-5	1994	Expression of the CREB transcript was also decreased by EDS-induced androgen withdrawal, but not by FSH or EDS + T. In situ hybridization of paraffin-embedded testis sections probed with digoxigenin-labeled riboprobes confirmed the localization of CREB and CREM mRNA to the same cell types as found with RT/PCR.	Paraffin	141-149	cAMP responsive element binding protein 1	Rattus norvegicus	18-22
15022399-4	2003	MATERIAL AND METHODS: The analysis of HSP73 and HSP72 was done by immunoperoxidase on routinely processed paraffin sections with prior antigen retrieval.	Paraffin	106-114	heat shock protein family A (Hsp70) member 8	Homo sapiens	38-43
7915836-1	1994	Since immunohistochemical detection of proliferating cell nuclear antigen (PCNA) is closely related to the cell cycle, this method can be used to visualize proliferative activity in paraffin sections of benign and premalignant cervical lesions.	Paraffin	182-190	proliferating cell nuclear antigen	Homo sapiens	39-73
14508401-6	2003	Immunohistochemical analysis with anti-tuberin antibodies on paraffin-embedded tissue sections showed loss of tuberin immunostaining in tumor cells but normal expression in residual normal pancreas.	Paraffin	61-69	TSC complex subunit 2	Homo sapiens	39-46
7915836-1	1994	Since immunohistochemical detection of proliferating cell nuclear antigen (PCNA) is closely related to the cell cycle, this method can be used to visualize proliferative activity in paraffin sections of benign and premalignant cervical lesions.	Paraffin	182-190	proliferating cell nuclear antigen	Homo sapiens	75-79
7936762-8	1994	PCNA was detected immunohistochemically on formalin fixed and paraffin embedded biopsies, and positive cells were evaluated in a crude percent count.	Paraffin	62-70	proliferating cell nuclear antigen	Homo sapiens	0-4
7911730-2	1994	Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin section was reported as an index for cellular proliferation and well-correlated with the histopathological grading of certain systemic malignancies.	Paraffin	64-72	proliferating cell nuclear antigen	Homo sapiens	0-34
7911730-2	1994	Proliferating cell nuclear antigen (PCNA) immunolocalization in paraffin section was reported as an index for cellular proliferation and well-correlated with the histopathological grading of certain systemic malignancies.	Paraffin	64-72	proliferating cell nuclear antigen	Homo sapiens	36-40
7911731-3	1994	METHODS: In this study, PCNA was identified by utilizing streptavidin-biotin immunoperoxidase technique on formalin-fixed, paraffin-embedded tissue sections of 32 hepatocellular carcinomas that were obtained from resected surgical specimens.	Paraffin	123-131	proliferating cell nuclear antigen	Homo sapiens	24-28
8313371-1	1994	We have studied expression of the urokinase receptor (u-PAR) in paraffin-embedded breast tissues at various stages of malignant progression.	Paraffin	64-72	plasminogen activator, urokinase receptor	Homo sapiens	54-59
7911817-1	1994	The immunohistochemical determination of the accessory protein of DNA-polymerase delta (PCNA), a marker of an early S-phase of the cell cycle, was used to evaluate cell proliferation retrospectively in formalin-fixed, paraffin-embedded liver biopsy sections in a group of patients with cirrhosis of similar age and duration of follow up, and with no evidence of hepatocellular carcinoma (41), including 17 patients with and 24 without hepatocellular carcinoma appearance during follow up.	Paraffin	218-226	proliferating cell nuclear antigen	Homo sapiens	88-92
7911996-1	1994	Simultaneous detection of intercellular adhesion molecules-1 (ICAM-1) and carcinoembryonic antigen (CEA) was investigated in AMeX (Acetone, Methyl benzoate and Xylene)-fixed, paraffin-embedded tumor sections of 24 adenocarcinomas of the lung, using the avidin-biotin-peroxidase complex (ABC) method.	Paraffin	175-183	CEA cell adhesion molecule 5	Homo sapiens	100-103
8132871-4	1994	CRH neurons were immunocytochemically detected in 6 microns paraffin sections with the aid of a highly specific monoclonal antibody to CRH.	Paraffin	60-68	corticotropin releasing hormone	Homo sapiens	0-3
7913362-3	1994	An anti-PCNA antibody, PC10(Dako), was applied for the detection of proliferating cell nuclear antigen (PCNA) in paraffin embedded tissue sections.	Paraffin	113-121	proliferating cell nuclear antigen	Homo sapiens	8-12
7913362-3	1994	An anti-PCNA antibody, PC10(Dako), was applied for the detection of proliferating cell nuclear antigen (PCNA) in paraffin embedded tissue sections.	Paraffin	113-121	proliferating cell nuclear antigen	Homo sapiens	68-102
7913362-3	1994	An anti-PCNA antibody, PC10(Dako), was applied for the detection of proliferating cell nuclear antigen (PCNA) in paraffin embedded tissue sections.	Paraffin	113-121	proliferating cell nuclear antigen	Homo sapiens	104-108
8176764-7	1994	In the preparation of paraffin embedded tissue, the high background debris and wide range of coefficients of variation had some interference in the interpretation for the histogram of FCM (only 80% of the cases studied are interpretable).	Paraffin	22-30	nucleolar protein 3	Homo sapiens	184-187
7910610-1	1994	The proliferative activity in 70 cases of soft-tissue tumours was estimated immunohistochemically using the monoclonal antibody PC-10, which recognizes proliferating-cell nuclear antigen (PCNA) in paraffin sections.	Paraffin	197-205	proliferating cell nuclear antigen	Homo sapiens	188-192
7941803-2	1994	PCNA-expression (Proliferating Cell Nuclear Antigen) was immunohistochemically assessed using formalin-fixed, paraffin-embedded tissue.	Paraffin	110-118	proliferating cell nuclear antigen	Homo sapiens	0-4
7941803-2	1994	PCNA-expression (Proliferating Cell Nuclear Antigen) was immunohistochemically assessed using formalin-fixed, paraffin-embedded tissue.	Paraffin	110-118	proliferating cell nuclear antigen	Homo sapiens	17-51
7902777-3	1993	METHODS: SCC antigen was immunohistochemically stained in Grade 3 pT1 TCC of the bladder that had been fixed in formaldehyde solution and embedded in paraffin.	Paraffin	150-158	serpin family B member 3	Homo sapiens	9-12
8372941-13	1993	We conclude that (a) an immunohistochemical panel including CD20, CD43, CD68, and MPO can successfully identify the vast majority (96%) of EMT in paraffin sections, and (b) there is an association between morphology and phenotype in these lesions.	Paraffin	146-154	IL2 inducible T cell kinase	Homo sapiens	139-142
7913437-3	1993	The results indicate that PCNA/Cyclin detection is a reliable method to examine the fraction of proliferating cells of thyroid carcinoma on paraffin sections, and it could be used to determine the prognosis of thyroid carcinoma.	Paraffin	140-148	proliferating cell nuclear antigen	Homo sapiens	26-37
7690737-3	1993	Anti-PCNA monoclonal antibody PC10 was applied to formalin-fixed, paraffin-embedded tissue using the avidin-biotin method.	Paraffin	66-74	proliferating cell nuclear antigen	Homo sapiens	5-9
8352531-1	1993	The immunohistochemical expression of C-myc p62 oncoprotein was investigated using the immunoperoxidase method and the monoclonal antibody (Mab) MYC 1-9E10 in bone marrow paraffin sections.	Paraffin	171-179	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	38-43
8098267-4	1993	METHODS: A quantitative immunocytochemical assay for PCNA was performed on 82 primary invasive breast carcinomas fixed in formaldehyde solution and embedded in paraffin and 18 corresponding axillary metastases.	Paraffin	160-168	proliferating cell nuclear antigen	Homo sapiens	53-57
8099452-11	1993	CONCLUSIONS: Because PCNA immunostaining can be done in routine formalin-fixed paraffin-embedded sections, this could be a powerful tool for providing information about the prognosis of patients with gastric cancer.	Paraffin	79-87	proliferating cell nuclear antigen	Homo sapiens	21-25
7684024-2	1993	Recently, antibodies to the proliferating cell nuclear antigen (PCNA)/cyclin reactive in paraffin-embedded sections have become available.	Paraffin	89-97	proliferating cell nuclear antigen	Homo sapiens	28-69
7684024-8	1993	In summary, PCNA staining of either B5- or formalin-fixed, paraffin-embedded tissue sections is a simple aid in the objective categorization of FCC lymphomas and may offer additional potentially prognostic information in some FCC subsets and in CC lymphomas.	Paraffin	59-67	proliferating cell nuclear antigen	Homo sapiens	12-16
8095851-2	1993	METHODS: PCNA labeling rates (LR) were quantified in 121 paraffin-embedded biopsy specimens from primary tumors by immunocytochemistry.	Paraffin	57-65	proliferating cell nuclear antigen	Homo sapiens	9-13
14633450-0	2003	[Detection of COL1A1/PDGFB fusion transcripts in dermatofibroscoma protuberans by revers transcriptase-polymerase chain reaction using paraffin-embedded tissues].	Paraffin	135-143	collagen type I alpha 1 chain	Homo sapiens	14-20
14633450-0	2003	[Detection of COL1A1/PDGFB fusion transcripts in dermatofibroscoma protuberans by revers transcriptase-polymerase chain reaction using paraffin-embedded tissues].	Paraffin	135-143	platelet derived growth factor subunit B	Homo sapiens	21-26
8438787-7	1993	These findings show that antibodies UCHL1, beta F1, and L26 can be used to determine the numbers of B and T lymphocytes in paraffin-embedded, formalin-fixed bone marrow specimens and thus may help to distinguish reactive T lymphocytosis from B-cell lymphoma.	Paraffin	123-131	ubiquitin C-terminal hydrolase L1	Homo sapiens	36-41
14513155-1	2003	In the past few years, the monoclonal antibody MIB-1 has been used by researchers in order to retrospectively study paraffin imbibed tumor fragments.	Paraffin	116-124	MIB E3 ubiquitin protein ligase 1	Homo sapiens	47-52
8443050-3	1993	The ability to measure MYCN amplification from smaller amounts of tumor DNA also permits measurement from Tru-cut biopsy samples and opens the possibility of retrospective measurement of MYCN status from single paraffin sections of archival material.	Paraffin	211-219	MYCN proto-oncogene, bHLH transcription factor	Homo sapiens	23-27
14506155-5	2003	EXPERIMENTAL DESIGN: We analyzed ARHI expression in DCIS, invasive breast carcinoma, and adjacent normal breast epithelium from 64 formalin-fixed, paraffin-embedded DCIS specimens by both immunohistochemistry and in situ hybridization.	Paraffin	147-155	DIRAS family GTPase 3	Homo sapiens	33-37
12821338-9	2003	Three of 22 (13.6%) touch preparations and 1 of 14 (7.1%) paraffin samples had amplified levels of CA125.	Paraffin	58-66	mucin 16, cell surface associated	Homo sapiens	99-104
1476918-1	1992	Interleukin 1 (IL-1) immunoreactivity in sebaceous glands was studied in paraffin sections of normal human skin.	Paraffin	73-81	interleukin 1 alpha	Homo sapiens	0-19
12714638-5	2003	In addition, HLA-A2 and -G expression was investigated by immunohistochemistry in paraffin-embedded tumor sections from these patients.	Paraffin	82-90	major histocompatibility complex, class I, G	Homo sapiens	13-26
21584615-0	1992	A comparative immunohistochemical study of p53 and proliferating-cell nuclear antigen expression in microwave-fixed paraffin sections of colorectal tumors.	Paraffin	116-124	proliferating cell nuclear antigen	Homo sapiens	51-85
12753172-6	2003	METHODS: Since the biologic function of NT-3 is mediated primarily through Trk-C, we investigated Trk-C immunoexpression on paraffin sections of 10 compound nevi and 63 melanomas.	Paraffin	124-132	neurotrophic receptor tyrosine kinase 3	Homo sapiens	98-103
12579307-0	2003	In situ detection of O6-methylguanine-DNA methyltransferase messenger RNA in paraffin-embedded human astrocytic tumor tissues by nested in situ RT-PCR is useful in predicting chemotherapy-resistance of tumors.	Paraffin	77-85	O-6-methylguanine-DNA methyltransferase	Homo sapiens	21-59
21584615-1	1992	This paper reports on a comparative immunohistochemical study of p53 and proliferating-cell nuclear antigen (PCNA) performed on microwave (MW)-fixed paraffin sections of 24 colorectal carcinomas and 68 adenomas in order to investigate the relationship between p53 expression and proliferative activity.	Paraffin	149-157	proliferating cell nuclear antigen	Homo sapiens	109-113
12579274-2	2003	By means of immunohistochemical methods, Bak expression was evaluated in formalin-fixed, paraffin-embedded diagnostic specimens from 83 patients with T1-T4 oral tongue squamous cell carcinomas (SCC).	Paraffin	89-97	BCL2 antagonist/killer 1	Homo sapiens	41-44
1362576-2	1992	A commercially available antibody to proliferating cell nuclear antigen was used to characterize and compare proliferating cell populations in paraffin sections of benign, premalignant, and malignant lesions of human epidermis using routine immunohistochemical techniques.	Paraffin	143-151	proliferating cell nuclear antigen	Homo sapiens	37-71
1285276-6	1992	IHC and ISH analyses showed that all cases were positive for gastrin protein and 24 of 25 (96%) expressed gastrin mRNA that was easily detected in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	163-171	gastrin	Homo sapiens	106-113
12556294-5	2003	MIB-1 was the proliferative marker used on paraffin sections.	Paraffin	43-51	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
12887776-2	2003	METHODS: Immunohistochemical method was used to detect the BRCA1 protein in paraffin embedded breast cancer tissue of 51 patients.	Paraffin	76-84	BRCA1 DNA repair associated	Homo sapiens	59-64
1354428-11	1992	It is our conclusion that immunologic PCNA positivity in paraffin sections correlates with fresh flow cytometric S + G2 + M in lymph nodes, although careful attention must be paid to the area of the node quantified for PCNA.	Paraffin	57-65	proliferating cell nuclear antigen	Homo sapiens	38-42
12971412-6	2003	The p53-dependent apoptosis related Bax proteins on formalin-fixed paraffin-embedded sections were stained by the avidin-biotin peroxidase complex method.	Paraffin	67-75	BCL2-associated X protein	Mus musculus	36-39
1372584-6	1992	Subsequently, we determined the nuclear expression of proliferating cell nuclear antigen on archival paraffin-embedded samples of the normal human liver (8 cases), acute nonfulminant hepatitis (10 cases) and fulminant hepatitis (4 cases).	Paraffin	101-109	proliferating cell nuclear antigen	Homo sapiens	54-88
12506063-3	2003	Immunohistochemical detection of the vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR1) was performed in paraffin-embedded sections.	Paraffin	120-128	vascular endothelial growth factor A	Mus musculus	37-71
12506063-3	2003	Immunohistochemical detection of the vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR1) was performed in paraffin-embedded sections.	Paraffin	120-128	vascular endothelial growth factor A	Mus musculus	73-77
12506063-3	2003	Immunohistochemical detection of the vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR1) was performed in paraffin-embedded sections.	Paraffin	120-128	FMS-like tyrosine kinase 1	Mus musculus	88-93
12506063-3	2003	Immunohistochemical detection of the vascular endothelial growth factor (VEGF) receptor Flt-1 (VEGFR1) was performed in paraffin-embedded sections.	Paraffin	120-128	FMS-like tyrosine kinase 1	Mus musculus	95-101
1349881-5	1992	PCNA is a nuclear antigen which is essential for DNA synthesis, two commercially available antibodies to PCNA work in paraffin-embedded tissue, but may have different staining characteristics under different conditions of fixation.	Paraffin	118-126	proliferating cell nuclear antigen	Homo sapiens	0-4
12432552-5	2002	These antibodies, which are applicable in ELISA, immunofluorescence, immunoprecipitation, immunoblotting and immunohistochemistry on paraffin sections, are the first variant-specific anti-LMP1 monoclonal antibodies produced, and will be useful in investigating the functional significance of 335D in NPC.	Paraffin	133-141	PDZ and LIM domain 7	Homo sapiens	188-192
12473599-3	2002	We developed an immunohistochemical assay suitable for the detection of pRb2/p130, the last discovered member of the retinoblastoma gene family, on formalin-fixed and paraffin-embedded sections.	Paraffin	167-175	RB transcriptional corepressor like 2	Homo sapiens	77-81
1349881-5	1992	PCNA is a nuclear antigen which is essential for DNA synthesis, two commercially available antibodies to PCNA work in paraffin-embedded tissue, but may have different staining characteristics under different conditions of fixation.	Paraffin	118-126	proliferating cell nuclear antigen	Homo sapiens	105-109
12473599-10	2002	This study demonstrates for the first time the potential independent prognostic value of pRb2/p130 expression on formalin-fixed, paraffin-embedded sections from lung cancer patients.	Paraffin	129-137	RB transcriptional corepressor like 2	Homo sapiens	94-98
1564457-4	1992	When in situ hybridization was performed on paraffin sections of the abdominal ganglion, clusters of smaller cells located in the left hemiganglion, were also found to express either the LUQ-1 or the L5-67 gene, never both.	Paraffin	44-52	bradykinin-like neuropeptide	Aplysia californica	187-192
1584959-4	1992	Gliafibrillar acid protein (GFAP) and vimentin proved to be of particularly high stability and, consequently, were easily detectable from paraffin material.	Paraffin	138-146	vimentin	Homo sapiens	38-46
12609061-2	2002	METHODS: Immunohistochemical method was used to detect the expression of BSAP in 33 samples of formalin-fixed, paraffin-embedded tissues of cHL.	Paraffin	111-119	paired box 5	Homo sapiens	73-77
12404291-4	2002	METHODS: The authors assessed the immunohistochemical expression of VEGF and metalloproteinases MMP-2 and MMP-9 in paraffin embedded biopsy specimens of malignant melanomas (18 invasive melanomas and 10 in situ melanomas); dysplastic nevi with architectural disorder and cytologic atypia of melanocytes; Spitz nevi; and compound or predominantly intradermal, ordinary, benign melanocytic nevi.	Paraffin	115-123	matrix metallopeptidase 9	Homo sapiens	106-111
1567186-9	1992	Our results show that it is possible to quantitate the expression of the tumour markers CEA, TPA and CA 50 in breast cancer in paraffin sections.	Paraffin	127-135	pregnancy specific beta-1-glycoprotein 2	Homo sapiens	88-91
12371152-3	2002	Numerous studies based on immunohistochemical analyses of paraffin-embedded or frozen tissue sections using different monoclonal antibodies to CD44 isoforms and molecular biological techniques have provided evidence that in many types of tumours there is overexpression of CD44 isoforms and aberrant processing of immature CD44 transcripts relative to non-neoplastic control tissues, suggesting a role of CD44 in tumour development and progression.	Paraffin	58-66	CD44 antigen	Mus musculus	143-147
1516585-4	1992	P21 product of H-ras and P62 product of c-myc genes were detected in paraffin embedded parallel tissue sections.	Paraffin	69-77	H3 histone pseudogene 16	Homo sapiens	0-3
12223423-0	2002	Comparison of techniques for the successful detection of BRCA1 mutations in fixed paraffin-embedded tissue.	Paraffin	82-90	BRCA1 DNA repair associated	Homo sapiens	57-62
1516585-4	1992	P21 product of H-ras and P62 product of c-myc genes were detected in paraffin embedded parallel tissue sections.	Paraffin	69-77	HRas proto-oncogene, GTPase	Homo sapiens	15-20
12043011-3	2002	It was the aim of this study to examine the sites of expression of RANKL and RANK in the corresponding cells of human dental hard and periodontal tissues using immunohistochemical light microscopical methods on tissue sections of 15 paraffin-embedded human deciduous teeth undergoing root resorption.	Paraffin	233-241	TNF superfamily member 11	Homo sapiens	67-72
1516585-4	1992	P21 product of H-ras and P62 product of c-myc genes were detected in paraffin embedded parallel tissue sections.	Paraffin	69-77	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	40-45
1804308-2	1991	For this reason we attempted to localize IL-1 alpha and IL-1 beta directly on formalin-fixed paraffin-embedded normal human placentae at different stages of pregnancy using immunohistochemical techniques and specific antibodies.	Paraffin	93-101	interleukin 1 alpha	Homo sapiens	41-51
12115486-3	2002	CT7-33 was effective in frozen as well as formalin-fixed, paraffin-embedded tissues, and immunohistochemistry/reverse transcriptase polymerase chain reaction (RT-PCR) co-typing demonstrated antibody specificity.	Paraffin	58-66	MAGE family member C1	Homo sapiens	0-3
11972514-3	2002	We have developed a fluorescent in situ hybridization (FISH)-based technique for the retrospective analysis of the effect of BCL6 gene rearrangements on survival, using nuclei extracted from paraffin-embedded tissue.	Paraffin	191-199	BCL6 transcription repressor	Homo sapiens	125-129
1719801-2	1991	Monitoring of the quality of antigen preservation and the uniformity of tissue fixation in paraffin-embedded, formaldehyde-fixed tissues is facilitated by the routine use of an antibody to an epitope of vimentin that is partially susceptible to formaldehyde fixation.	Paraffin	91-99	vimentin	Homo sapiens	203-211
1758871-1	1991	The monoclonal antibody mES 13 was previously produced against bacterially expressed BALB ras p21 and was reported to have both membrane and cytoplasmic reactivity in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	183-191	esterase 13	Mus musculus	24-30
21320401-4	2002	Immunohistochemical methods were employed to detect the expression of cyclin D1 and p53 in paraffin-embeded tissues.	Paraffin	91-99	cyclin D1	Mus musculus	70-79
1758871-8	1991	The mES 13 antibody should be useful in the characterization and diagnosis of tumors in which oncocytoma is in the differential diagnosis, especially when only paraffin-embedded tissue is available for study.	Paraffin	160-168	esterase 13	Mus musculus	4-10
14626344-1	2002	In a previous study, we showed that the high level of protein tyrosine phosphorylation present in lymphomas containing an anaplastic lymphoma kinase (ALK) can be demonstrated in routinely processed paraffin tissue sections using immunolabelling techniques.	Paraffin	198-206	ALK receptor tyrosine kinase	Homo sapiens	122-148
14626344-1	2002	In a previous study, we showed that the high level of protein tyrosine phosphorylation present in lymphomas containing an anaplastic lymphoma kinase (ALK) can be demonstrated in routinely processed paraffin tissue sections using immunolabelling techniques.	Paraffin	198-206	ALK receptor tyrosine kinase	Homo sapiens	150-153
1680784-2	1991	A new monoclonal antibody (PC10) to genetically engineered PCNA has been shown to label proliferating cells in formalin-fixed paraffin-embedded normal human tissues.	Paraffin	126-134	proliferating cell nuclear antigen	Homo sapiens	59-63
11852356-7	2001	ETV6-NK3 chimeric RNA was detected by reverse transcriptase polymerase chain reaction in two cases out four cases from paraffin-embedded tissue blocks.	Paraffin	119-127	NK3 homeobox 1	Homo sapiens	5-8
1704391-9	1991	MAb 4D4 also recognized proacrosin in paraffin-embedded human testis sections.	Paraffin	38-46	acrosin	Homo sapiens	24-34
11679947-13	2001	Thus, RT-PCR detection of EWS-CHN or TAF2N-CHN fusion gene using archival paraffin-embedded tissue is a feasible and useful ancillary technique for the diagnosis of EMCS.	Paraffin	74-82	TATA-box binding protein associated factor 15	Homo sapiens	37-42
11511839-6	2001	RESULTS: Excellent concordance comparing frozen and paraffin embedded CD7 immunostaining (88%) was observed.	Paraffin	52-60	CD7 molecule	Homo sapiens	70-73
11511839-7	2001	CD7 deletion and TCR-gamma PCR was sensitive (94%) and specific (96%) for a diagnosis of MF using paraffin-embedded biopsy specimens.	Paraffin	98-106	CD7 molecule	Homo sapiens	0-3
11511839-8	2001	CONCLUSION: In the diagnosis of MF, detection of CD7 deletion and monoclonal TCR rearrangements can be successfully performed in a cost-effective, timely fashion using routine formalin-fixed paraffin-embedded biopsy specimens.	Paraffin	191-199	CD7 molecule	Homo sapiens	49-52
1814747-2	1991	Using an ABC immunoencymatic staining technique and a P21-specific monoclonal antibody, SCI-Oncogema I, we have detected the expression of P21 in formalin-fixed, paraffin-embedded samples from 53 bladder tumors and 7 normal bladder mucosae.	Paraffin	162-170	H3 histone pseudogene 16	Homo sapiens	139-142
11692211-5	2001	Immunohistochemical demonstration of HSP expression was performed using specific monoclonal antibodies after wet autoclave antigen retrieval on sections from either Carnoy-fixed (biopsies) or formalin-fixed (transplant nephrectomies) and paraffin-embedded tissue.	Paraffin	238-246	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	37-40
1670579-1	1991	Monoclonal antibodies (MAb) to a 36 KD protein, proliferating cell nuclear antigen (PCNA/cyclin), have been previously shown to be capable of identifying proliferating cells in vitro as well as in alcohol-fixed, paraffin-embedded tissue specimens.	Paraffin	212-220	proliferating cell nuclear antigen	Homo sapiens	48-82
11473453-5	2001	Immunohistochemistry of the paraffin section for CD30 in our index case confirmed unequivocal CD30(+) pleomorphic cells in the malignant nodules in occasional clusters.	Paraffin	28-36	TNF receptor superfamily member 8	Homo sapiens	49-53
11473453-5	2001	Immunohistochemistry of the paraffin section for CD30 in our index case confirmed unequivocal CD30(+) pleomorphic cells in the malignant nodules in occasional clusters.	Paraffin	28-36	TNF receptor superfamily member 8	Homo sapiens	94-98
11473453-6	2001	This case prompted a study of additional cases of FL for pattern of immunoreactivity with CD30 on paraffin sections.	Paraffin	98-106	TNF receptor superfamily member 8	Homo sapiens	90-94
1670579-1	1991	Monoclonal antibodies (MAb) to a 36 KD protein, proliferating cell nuclear antigen (PCNA/cyclin), have been previously shown to be capable of identifying proliferating cells in vitro as well as in alcohol-fixed, paraffin-embedded tissue specimens.	Paraffin	212-220	proliferating cell nuclear antigen	Homo sapiens	84-95
11473453-8	2001	RESULTS: This study demonstrated 32% of the additional cases of FL had definitive CD30(+), large, pleomorphic malignant cells by paraffin immunohistochemistry.	Paraffin	129-137	TNF receptor superfamily member 8	Homo sapiens	82-86
2038128-1	1991	In order to study the localization of Lentil lectin (LCH)-binding glycoresidues in glomeruli from patients with a variety of glomerulopathies, and to elucidate the relationship between LCH-binding sugars and the components of the extracellular matrix, laminin and type IV collagen, investigations of formalin-fixed, paraffin-embedded kidney tissues digested with trypsin were carried out by the direct and indirect immunofluorescence microscopy techniques.	Paraffin	316-324	LCH	Homo sapiens	53-56
11593961-0	2001	Immunohistochemical localization of deleted-in-colon-cancer (DCC) protein in human epithelial, neural, and neuro-endocrine tissues in paraffin sections with antigen retrieval.	Paraffin	134-142	DCC netrin 1 receptor	Homo sapiens	61-64
2355176-13	1990	The antiserum to MG-160 represents a reliable reagent for immunohistochemical visualization of the Golgi apparatus in brain and several other human tissues obtained at autopsy, fixed with Bouin"s, and embedded in paraffin.	Paraffin	213-221	golgi glycoprotein 1	Homo sapiens	17-23
11436657-5	2001	ELISA, dot blot hybridization and immunohistochemistry demonstrated that the human single chain Fv antibody against hepatitis C NS3 antigen has a specific combination character with hepatitis C virus NS3 antigen of different sources and paraffin-embedded patients tissues, it didn"t react with liver tissue and HBsAg.	Paraffin	237-245	KRAS proto-oncogene, GTPase	Homo sapiens	128-131
2232291-4	1990	The specimens for this study were paraffin-embedded tissue section of SCC stained with azocarmin G for blocking the non-specific fluorescence.	Paraffin	34-42	serpin family B member 3	Homo sapiens	70-73
11359391-3	2001	METHODS: IL-15 mRNA and protein expression were examined by in situ hybridization and immunohistochemistry, respectively, on formalin-fixed, paraffin-embedded biopsies of normal human skin, atopic dermatitis, psoriasis, parapsoriasis and CTCL.	Paraffin	141-149	interleukin 15	Homo sapiens	9-14
2325796-3	1990	EGF precursor cDNA was hybridized to both paraffin-embedded and frozen sections of mouse kidney.	Paraffin	42-50	epidermal growth factor	Mus musculus	0-3
11344244-7	2001	In addition, in situ hybridization on fresh-frozen and paraffin-embedded sections confirmed the presence of TSHR transcripts in thyroid and EOM, but not in abdominal or cardiac muscle.	Paraffin	55-63	thyroid stimulating hormone receptor	Homo sapiens	108-112
11242790-1	2001	A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues.	Paraffin	105-113	neurotrophic receptor tyrosine kinase 3	Homo sapiens	74-79
2100787-2	1990	Immunohistochemical reactions on paraffin sections from the tumour were directed towards the presence of desmin , vimentin and neurospecific enolase.	Paraffin	33-41	desmin	Homo sapiens	105-111
11242790-11	2001	These results show the diagnostic usefulness of RT-PCR methods to detect ETV6-NTRK3 fusion transcripts in archival formalin-fixed paraffin-embedded tissue and the important role of NTRK3 in the development of CIFS, despite its being a protein of little importance in differential diagnosis.	Paraffin	130-138	neurotrophic receptor tyrosine kinase 3	Homo sapiens	78-83
33940787-3	2022	This study aimed to analyze the capturing of TERT mutations by targeted next-generation sequencing (NGS) using formalin-fixed paraffin-embedded tissues.	Paraffin	126-134	telomerase reverse transcriptase	Homo sapiens	45-49
11226731-4	2001	Paraffin sections of the fetal brains on embryonic day (ED) 10, 12, 14, 16 and 18 were applied for the immunostains of Bcl-2 and Bax.	Paraffin	0-8	BCL2-associated X protein	Mus musculus	129-132
11209122-2	2001	OBJECTIVE: Our purpose was to determine the staining pattern and usefulness of MIB-1 antibody, which recognizes Ki-67 antigen in formalin-fixed, paraffin-embedded tissue, as an adjunct to the histopathologic differential diagnosis of SN.	Paraffin	145-153	MIB E3 ubiquitin protein ligase 1	Homo sapiens	79-84
33776450-7	2021	Immunohistochemistry was performed to confirm expression of DNASE1L3 in paraffin-embedded tissues of HCC (n=9) and lung adenocarcinoma (n=20).	Paraffin	72-80	deoxyribonuclease 1 like 3	Homo sapiens	60-68
11165019-4	2001	Immunohistochemical studies on 10% formalin fixed and paraffin embedded sections of human tissues showed that Pan1b was present in acini and ciliated epithelia of the lung.	Paraffin	54-62	hydroxysteroid 17-beta dehydrogenase 11	Homo sapiens	110-115
34980577-7	2021	METHODS: We used clinically-validated IHC assays to assess the expression of hMLH1, hMSH2, hMSH6, and/or hPMS2 in formalin-fixed paraffin-embedded tissue sections of bone marrow core biopsies from patients diagnosed with AML.	Paraffin	129-137	mutL homolog 1	Homo sapiens	77-82
11268705-1	2001	CD 68 antibodies are most frequently used as a reliable paraffin marker of histiocytes.	Paraffin	56-64	CD68 molecule	Homo sapiens	0-5
34980577-7	2021	METHODS: We used clinically-validated IHC assays to assess the expression of hMLH1, hMSH2, hMSH6, and/or hPMS2 in formalin-fixed paraffin-embedded tissue sections of bone marrow core biopsies from patients diagnosed with AML.	Paraffin	129-137	PMS1 homolog 2, mismatch repair system component	Homo sapiens	105-110
34227915-3	2021	We used the immunohistochemical staining to evaluate Stabilin-2 protein expression in formalin-fixed paraffin-embedded tissue of NSCLC patients" primary lesion.	Paraffin	101-109	stabilin 2	Homo sapiens	53-63
11166147-4	2001	Immunohistochemical detection of Glut1 protein was examined in 141 formalin-fixed and paraffin-embedded colorectal tumour specimens (57 adenomas, 84 carcinomas).	Paraffin	86-94	solute carrier family 2 member 1	Homo sapiens	33-38
11374842-5	2001	In all patients, paraffin sections were treated with antibodies against placental-like alkaline phosphatase (PLAP), a classic immunohistochemical marker of GCT and CIS.	Paraffin	17-25	alkaline phosphatase, germ cell	Homo sapiens	72-107
34513680-3	2021	Methods: PD-L1 expression was evaluated using paraffin-embedded specimens from patients with surgically treated high-grade SGC, and it was scored by the tumor proportion score (TPS), combined positive score (CPS), and immune cell (IC) score.	Paraffin	46-54	CD274 molecule	Homo sapiens	9-14
18521440-2	2001	A mouse monoclonal antibody raised against an 18 amino acid segment of the aP2 protein was found to react with lipoblasts and fetal fat cells in paraffin sections of soft tissue tumours of adipose differentiation.	Paraffin	145-153	transcription factor AP-2 alpha	Homo sapiens	75-78
11123763-10	2000	Although chromosome analysis was not performed, EWS-FLI1 chimera gene was identified by reverse transcriptase-polymerase chain reaction on the freshly frozen specimen and fluorescence in situ hybridization on paraffin sections.	Paraffin	209-217	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	52-56
34456727-6	2021	SMG9 protein expression was analyzed in ninety-five sets of paired formalin-fixed and paraffin-embedded tissue specimens by immunohistochemistry (IHC).	Paraffin	86-94	SMG9 nonsense mediated mRNA decay factor	Homo sapiens	0-4
11013367-1	2000	BACKGROUND: MIB-1, a murine monoclonal antibody, recognizes the Ki-67 antigen of routinely processed paraffin sections after microwave treatment.	Paraffin	101-109	MIB E3 ubiquitin protein ligase 1	Homo sapiens	12-17
11012744-10	2000	Neoplastic cells in paraffin-embedded tissue specimens from these patients had CD3(CD3epsilon)+ CD56(123C3)+ granzyme+ TIA-1+ EBERT+ CD43(MT1)- CD45RO(UCHL-1)- CD57(Leu7)- CD20(L26)- phenotypes.	Paraffin	20-28	protein tyrosine phosphatase receptor type C	Homo sapiens	144-148
34297545-1	2021	Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI MSI) is an established tool for the investigation of formalin-fixed paraffin-embedded (FFPE) tissue samples and shows a high potential for applications in clinical research and histopathological tissue classification.	Paraffin	145-153	RB binding protein 4, chromatin remodeling factor	Homo sapiens	77-80
34178624-3	2021	Materials and Methods: We verify a co-expression of BRAF V600E mutation and PD-L1 high expression more than 50% on formalin-fixed paraffin-embedded tumor sample of a newly diagnosed lung adenocarcinoma patient by immunohistochemistry and BRAF V600E/EGFR/ALK/ROS1 Mutations Detection Kit.	Paraffin	130-138	CD274 molecule	Homo sapiens	76-81
10946906-4	2000	Tumor expression of MMP-9 was investigated using a monoclonal antibody on a series of well-characterized paraffin-embedded sections of pituitary tumors.	Paraffin	105-113	matrix metallopeptidase 9	Homo sapiens	20-25
34199609-4	2021	We conducted immunohistochemistry using paraffin-embedded tissue samples from patients and found that most skin tumors express ASIC1/2 and TRPV1/4.	Paraffin	40-48	acid sensing ion channel subunit 1	Homo sapiens	127-134
10895816-7	2000	They subsequently developed reverse transcription-polymerase chain reaction (RT-PCR) assays that can detect ETV6-NTRK3 fusion transcripts in CFS frozen or paraffin-embedded tumor specimens.	Paraffin	155-163	neurotrophic receptor tyrosine kinase 3	Homo sapiens	113-118
34151862-5	2021	Formalin-fixed paraffin-embedded sections were immunohistochemically stained for pSyn, shown to be highly specific and sensitive for alpha-synuclein pathology.	Paraffin	15-23	synuclein alpha	Homo sapiens	133-148
10937677-2	2000	METHODS: The frequency of K-ras codon 12 point mutations was assessed in 52 paraffin-embedded tissues from 44 patients with oesophageal pathology.	Paraffin	76-84	KRAS proto-oncogene, GTPase	Homo sapiens	26-31
10843287-0	2000	CD10 and BCL-6 expression in paraffin sections of normal lymphoid tissue and B-cell lymphomas.	Paraffin	29-37	BCL6 transcription repressor	Homo sapiens	9-14
10843287-1	2000	In this study the authors explored the value of immunostaining for follicular center B-cell markers, BCL-6 and CD10, in paraffin sections as a tool for the differential diagnosis of B-cell lymphomas.	Paraffin	120-128	BCL6 transcription repressor	Homo sapiens	101-106
35397317-9	2022	MALAT1-GLI1 fusion was detected in formalin-fixed paraffin-embedded tissue using RT-PCR and Sanger sequencing.	Paraffin	50-58	metastasis associated lung adenocarcinoma transcript 1	Homo sapiens	0-6
35403870-2	2022	Immunohistochemistry (IHC) on formalin-fixed, paraffin-embedded (FFPE) tumor tissue has an established role in detecting PD-L1 expression and in ALK, ROS1, and more recently NTRK testing.	Paraffin	46-54	CD274 molecule	Homo sapiens	121-126
35133686-4	2022	METHODS: ADH expression patterns were characterized by density analysis of ADH immunohistochemistry (n = 21) and real-time RT-PCR of total RNAs by laser-capture microdissection (n = 10) and whole tissue formalin-fixed paraffin embedded prostate biopsies (n = 63).	Paraffin	218-226	alcohol dehydrogenase 1A (class I), alpha polypeptide	Homo sapiens	9-12
10828825-5	2000	11beta-Hydroxylase and aldosterone synthase were immunolocalised in paraffin-embedded rat adrenal and brain sections using mouse monoclonal antibodies.	Paraffin	68-76	cytochrome P450, family 11, subfamily b, polypeptide 2	Rattus norvegicus	23-43
10874665-6	2000	Mdm2 and p53 were demonstrated by immunohistology on formalin-fixed and paraffin-embedded tumor tissue.	Paraffin	72-80	MDM2 proto-oncogene	Homo sapiens	0-4
10815860-11	2000	CONCLUSIONS: The results show that the Drosophila patched gene LOH can be frequently identified in paraffin-embedded sporadic TE after routine processing and indicates a common gatekeeper mechanism for both TE and basal cell carcinoma.	Paraffin	99-107	patched	Drosophila melanogaster	50-57
35589508-5	2022	MATERIALS AND METHODS: ICC for PD-L1 was performed on formalin-fixed paraffin-embedded CBs of MPE and patient-matched histologic samples, if available, using the automated Ventana PD-L1 SP263 assay.	Paraffin	69-77	CD274 molecule	Homo sapiens	31-36
10815906-4	2000	The overexpression of mdm2 and p53 proteins was investigated on paraffin-embedded material by using monoclonal antibodies.	Paraffin	64-72	MDM2 proto-oncogene	Homo sapiens	22-26
35419208-3	2022	Methods: Immunohistochemical expression of NK1R and Ki-67 was measured in 164 paraffin-embedded breast cancer tissues of four molecular subtypes (42 HER2-enriched, 40 luminal A, 42 luminal B, and 40 triple negative).	Paraffin	78-86	tachykinin receptor 1	Homo sapiens	43-47
10885605-6	2000	Mutations in exons 5-8 of the TP53 gene and in codons 12 and 13 of the K-ras gene were assayed in paraffin-embedded tissue by the single-strand conformation polymorphism (SSCP) assay.	Paraffin	98-106	KRAS proto-oncogene, GTPase	Homo sapiens	71-76
10862210-19	2000	Immunostaining with anti-Ki-67 antibodies (MIB1) and p53 based on formalin-fixed paraffin-embedded material from 86 patients revealed that MIB-1 &gt; or = 10% was associated with poorer metastasis-free survival but p53 was not.	Paraffin	81-89	MIB E3 ubiquitin protein ligase 1	Homo sapiens	139-144
35359901-7	2022	Results: The frequencies of genotypes for RET rs2435357 in HSCR paraffin-embedded rectal were CC 0, CT 11 (15%), and TT 62 (85%), whereas their frequencies in HSCR blood samples were CC 4 (4.3%), CT 22 (23.7%), and TT 67 (72%).	Paraffin	64-72	ret proto-oncogene	Homo sapiens	42-45
10730978-2	2000	Paraffin sections of healthy antral follicles, early and late atretic ones, and early and late cystic ones were stained using the terminal deoxynucleotidyl transferase (Tdt)-mediated biotinylated deoxyuridine triphosphates (dUTP) nick end-labeling (TUNEL) method to detect apoptotic cells.	Paraffin	0-8	DNA nucleotidylexotransferase	Bos taurus	130-167
10730978-2	2000	Paraffin sections of healthy antral follicles, early and late atretic ones, and early and late cystic ones were stained using the terminal deoxynucleotidyl transferase (Tdt)-mediated biotinylated deoxyuridine triphosphates (dUTP) nick end-labeling (TUNEL) method to detect apoptotic cells.	Paraffin	0-8	DNA nucleotidylexotransferase	Bos taurus	169-172
34555379-3	2022	Immunofluorescence investigations of paraffin-embedded liver sections suggest that KIF12-associated impaired functional cell polarity may be the underlying cause.	Paraffin	37-45	kinesin family member 12	Homo sapiens	83-88
10746928-4	2000	In the present study, NAT1- and NAT2-specific riboprobes were used in hybridization histochemistry studies to localize NAT1 and NAT2 mRNA sequences in formalin-fixed, paraffin-embedded human tissue sections.	Paraffin	167-175	N-acetyltransferase 2	Homo sapiens	128-132
2698740-6	1989	Optimal results, i.e., with the least non-specific or incomplete staining, were obtained on PLP-fixed paraffin-embedded tissues.	Paraffin	102-110	proteolipid protein 1	Homo sapiens	92-95
10567908-1	1999	We report the generation of 2 monoclonal antibodies (MAbs), 2B12 and 3E6, suitable for the detection of human dUTPase in routinely processed paraffin sections by immunohistochemistry.	Paraffin	141-149	Deoxyuridine triphosphatase	Drosophila melanogaster	110-117
10667418-4	1999	From among these cases, the immunohistochemical expressions of c-fos and c-jun proto-oncogene products and bone matrix proteins of type I collagen, osteonectin, osteopontin, and osteocalcin were evaluated in 20 typical fibrous dysplasias and 17 osteofibrous dysplasias using paraffin sections, and these expressions were then assessed semiquantitatively.	Paraffin	275-283	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	63-68
10550296-3	1999	Here, the usefulness of conventional CD44 protein immunohistochemistry as a prognostic parameter for recurrence of superficial transitional cell carcinomas was assessed in paraffin sections of 241 tumors with long-term follow-up.	Paraffin	172-180	CD44 molecule (Indian blood group)	Homo sapiens	37-41
10556192-7	1999	CD30L, while expressed by some small lymphocytes, was most often coexpressed by CD30(+) neoplastic large cells, as demonstrated by 2-color immunofluorescence and by immunohistochemistry on paraffin sections.	Paraffin	189-197	TNF receptor superfamily member 8	Homo sapiens	0-4
10571511-2	1999	The detection of the cell cycle-specific antigens Ki-67, and the development of anti-Ki-67 antibodies, including the paraffin-reactive antibody MIB-1, have established immunohistochemical detection of cell cycle-specific antigens as a measure of proliferative activity in breast cancer diagnosis.	Paraffin	117-125	MIB E3 ubiquitin protein ligase 1	Homo sapiens	144-149
10565681-0	1999	Detection of COL1A1-PDGFB fusion transcripts in dermatofibrosarcoma protuberans by reverse transcription-polymerase chain reaction using archival formalin-fixed, paraffin-embedded tissues.	Paraffin	162-170	collagen type I alpha 1 chain	Homo sapiens	13-19
10565681-5	1999	In this present study, the investigators conducted a reverse transcription (RT)-polymerase chain reaction (PCR) assay to detect the COL1A1-PDGFB fusion transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from 12 patients with DFSP.	Paraffin	195-203	collagen type I alpha 1 chain	Homo sapiens	132-138
10565681-5	1999	In this present study, the investigators conducted a reverse transcription (RT)-polymerase chain reaction (PCR) assay to detect the COL1A1-PDGFB fusion transcripts using archival formalin-fixed, paraffin-embedded tumor specimens from 12 patients with DFSP.	Paraffin	195-203	platelet derived growth factor subunit B	Homo sapiens	139-144
10565681-7	1999	The COL1A1-PDGFB fusion transcripts could be detected in 10 of 12 paraffin-embedded DFSP tumor specimens (83%).	Paraffin	66-74	collagen type I alpha 1 chain	Homo sapiens	4-10
10565681-7	1999	The COL1A1-PDGFB fusion transcripts could be detected in 10 of 12 paraffin-embedded DFSP tumor specimens (83%).	Paraffin	66-74	platelet derived growth factor subunit B	Homo sapiens	11-16
10396291-8	1999	We analyzed Bcl-6 staining of formalin-fixed paraffin-embedded tissue from 72 indolent lymphomas including 31 grade I and II follicle center lymphomas (FCL).	Paraffin	45-53	BCL6 transcription repressor	Homo sapiens	12-17
10560503-2	1999	OBJECTIVE: To describe the advantages and limits of apoptosis detection on paraffin sections by TdT-mediated dUTP nick end labeling (TUNEL).	Paraffin	75-83	DNA nucleotidylexotransferase	Homo sapiens	96-99
10389907-4	1999	Using monoclonal antibodies applicable to immunohistochemical analysis of paraffin-embedded tissue sections, we found high-level expression of BRCA1 protein in normal mammary epithelium and various degrees of reduced expression in breast cancer cells.	Paraffin	74-82	BRCA1 DNA repair associated	Homo sapiens	143-148
10366470-3	1999	METHOD: We studied the expression of tenascin in normal tissue of the cervix uteri, cervical carcinoma in situ, and invasive cervical carcinoma in paraffin sections by immunohistochemistry using a monoclonal antibody.	Paraffin	147-155	tenascin C	Homo sapiens	37-45
9989450-6	1999	In immunohistochemical protocols on paraffin embedded tissue, antibodies to both tuberin and hamartin prominently labelled atypical and dysmorphic neuroglial cells that are a defining feature of TSC tubers.	Paraffin	36-44	TSC complex subunit 2	Homo sapiens	81-88
10755351-3	1999	EGF-R expression status was investigated in each group by immunohistochemistry on paraffin sections.	Paraffin	82-90	epidermal growth factor receptor	Rattus norvegicus	0-5
9860279-8	1998	We found scattered CD30+ cells in only one of six formalin-fixed paraffin-embedded acute atopic dermatitis biopsies, but in all of the respective snap-frozen specimens, possibly because CD30 expression on atopic dermatitis infiltrating cells is weak and sensitive to formalin fixation and paraffin embedding.	Paraffin	65-73	TNF receptor superfamily member 8	Homo sapiens	19-23
9860279-8	1998	We found scattered CD30+ cells in only one of six formalin-fixed paraffin-embedded acute atopic dermatitis biopsies, but in all of the respective snap-frozen specimens, possibly because CD30 expression on atopic dermatitis infiltrating cells is weak and sensitive to formalin fixation and paraffin embedding.	Paraffin	289-297	TNF receptor superfamily member 8	Homo sapiens	19-23
9781601-3	1998	C-fos protein expression was evaluated using archival formalin-fixed, paraffin-embedded tumor tissue, and an automated immunoperoxidase histochemical technique.	Paraffin	70-78	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
9796726-3	1998	With the advent of new monoclonal antibodies developed against T-cell antigens, including CD3, CD4, CD5, and CD8, it is now possible to immunophenotype T-cell subpopulations in paraffin-embedded tissues.	Paraffin	177-185	CD8a molecule	Homo sapiens	109-112
9853427-2	1998	MIB-1 expression was studied by immunohistochemistry on paraffin-embedded sections.	Paraffin	56-64	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
9605190-0	1998	Immunohistochemical detection of the DNA repair enzyme O6-methylguanine-DNA methyltransferase in formalin-fixed, paraffin-embedded astrocytomas.	Paraffin	113-121	O-6-methylguanine-DNA methyltransferase	Homo sapiens	55-93
9495203-5	1998	Automated immunohistochemistry was performed for CD44s expression on paraffin-embedded tissue sections using mouse antihuman CD44 antibody.	Paraffin	69-77	CD44 molecule (Indian blood group)	Homo sapiens	49-53
9548428-5	1998	We found statistically significant associations between the tumor cell proliferation rates measured by in vivo IdUrd labeling and MIB-1 expression in formalin-fixed paraffin-embedded tumors.	Paraffin	165-173	MIB E3 ubiquitin protein ligase 1	Homo sapiens	130-135
9589471-0	1998	Expression of KAI1 in paraffin-embedded normal, hyperplastic and neoplastic prostate and prostate carcinoma cell lines.	Paraffin	22-30	CD82 molecule	Homo sapiens	14-18
9589471-1	1998	Expression of KAI1, a tumor metastasis suppressor gene, was studied with different fixatives in frozen and paraffin-embedded sections of human and rat prostate carcinoma cell lines and human prostate lesions by immunohistochemistry.	Paraffin	107-115	CD82 molecule	Homo sapiens	14-18
9732156-3	1998	METHODS: Immunohistochemical analysis of SCF was performed in paraffin-embedded skin sections from the lesions of 18 patients with SSc (13 in the edematous and 5 in the sclerotic phase) and from normal skin of 5 subjects.	Paraffin	62-70	KIT ligand	Homo sapiens	41-44
9522210-2	1998	METHODS AND RESULTS: CD44H and variants (V4/V5, V6) expression was detected by immunohistochemistry in formalin-fixed, paraffin wax tissue samples of Barrett"s mucosa (50) and Barrett"s adenocarcinoma (73) obtained from surgical resections from 73 patients.	Paraffin	119-131	CD44 molecule (Indian blood group)	Homo sapiens	21-25
9591704-0	1998	Using 2-step PCR and restriction endonuclease digestion to detect K-ras mutation in paraffin-embedded tissues: is it reliable?	Paraffin	84-92	KRAS proto-oncogene, GTPase	Homo sapiens	66-71
9403705-0	1997	MAGE-3 immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Paraffin	43-51	MAGE family member A3	Homo sapiens	0-6
9416486-5	1997	Chondrocytes in normal articular cartilage and cartilage from osteoarthritic femoral heads stained positive for CD44 in both cryostat and paraffin sections.	Paraffin	138-146	CD44 molecule (Indian blood group)	Homo sapiens	112-116
9463579-6	1997	A chimeric transcript of the EWS/FLI-1 fusion gene detected by a nested reverse transcriptase-polymerase chain reaction using formalin-fixed paraffin-embedded tissue justified the diagnosis of pPNET.	Paraffin	141-149	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	33-38
9343323-16	1997	Moreover, we present data that suggests that evaluating for TdT in formalin-fixed paraffin-embedded tissue is a more sensitive test than using either 12E7, bcl-2 or CD34 alone.	Paraffin	82-90	DNA nucleotidylexotransferase	Homo sapiens	60-63
9268242-0	1997	Detection of three transthyretin gene mutations in familial amyloidotic polyneuropathy by analysis of DNA extracted from formalin-fixed and paraffin-embedded tissues.	Paraffin	140-148	transthyretin	Homo sapiens	19-32
9268242-1	1997	We identified three different missense mutations of the transthyretin (TTR) gene in three Japanese patients with familial amyloidotic polyneuropathy by analysis of their DNAs extracted from formalin-fixed and paraffin-embedded tissues.	Paraffin	209-217	transthyretin	Homo sapiens	56-69
9268242-1	1997	We identified three different missense mutations of the transthyretin (TTR) gene in three Japanese patients with familial amyloidotic polyneuropathy by analysis of their DNAs extracted from formalin-fixed and paraffin-embedded tissues.	Paraffin	209-217	transthyretin	Homo sapiens	71-74
9303485-2	1997	The prototype antibody Ki-67 reacted only with snap-frozen human tissue, but a novel antibody, MIB-1, was able to detect the Ki-67 antigen in paraffin wax-embedded human tissue.	Paraffin	142-154	MIB E3 ubiquitin protein ligase 1	Homo sapiens	95-100
18470734-3	1997	It is only immunohistology (CD20, CD43, CD68) of the paraffin blocks from the resection specimen that can lead to the final diagnosis of intermediate grade malignant lymphoma.	Paraffin	53-61	CD68 molecule	Homo sapiens	40-44
9274955-2	1997	In this study, we investigated this role by immunohistochemically staining PDGF and PDGF beta-receptors in paraffin-embedded dermatofibroma (DF), dermatofibrosarcoma protuberans (DFSP) and malignant fibrous histiocytoma (MFH) tissue.	Paraffin	107-115	platelet derived growth factor subunit B	Homo sapiens	84-93
10072869-2	1997	METHODS: In situ hybridization, polymeras Chain reaction (PCR) and immunohistochemical methods were used to detect EBV DNA, EBER1 and latent membrane protein 1 (LMP1) on paraffin embedded tissues of 18 MLEL cases and 14 BLEL cases.	Paraffin	170-178	PDZ and LIM domain 7	Homo sapiens	161-165
9191006-2	1997	In this study, proliferative potentials of chordomas were studied with an immunohistochemical staining method, mainly using anti-Ki-67 antibody, MIB-1, which is known to be available for archival paraffin sections, together with immunohistochemical studies on the expression of cell cycle or apoptosis-related proteins, including p53, cyclin D1, and bcl-2 proteins.	Paraffin	196-204	MIB E3 ubiquitin protein ligase 1	Homo sapiens	145-150
9267487-0	1997	The use of MAB 1977 monoclonal antibody for the immunohistochemical localization of beta 1 integrins in paraffin-embedded human kidney.	Paraffin	104-112	integrin subunit beta 1	Homo sapiens	84-100
9267487-9	1997	CONCLUSIONS: The method reported and discussed here may represent a valid tool for research and diagnostic applications based upon detection of beta 1 integrin in paraffin-embedded human tissues.	Paraffin	163-171	integrin subunit beta 1	Homo sapiens	144-159
9111215-5	1997	Mutations in K-ras and H-ras were identified by single-strand conformational analysis and direct sequencing of polymerase chain reaction (PCR) amplified DNA, isolated from paraffin-embedded sections of HG neoplasms.	Paraffin	172-180	Harvey rat sarcoma virus oncogene	Mus musculus	23-28
9215143-11	1997	CONCLUSION: PCR-SSP HLA class II DRB and DQB1 typing is reliably applicable to DNA extracted from formalin fixed and paraffin wax embedded tissue.	Paraffin	117-129	major histocompatibility complex, class II, DQ beta 1	Homo sapiens	41-45
9375023-1	1997	The recent availability of the monoclonal antibody MIB-1 (which is able to detect the human nuclear cell proliferation-associated antigen Ki-67 even on formalin-fixed, paraffin-embedded sections, microwave-treated and routinely processed for immunohistochemistry) could open new avenues for validation of the clinical role of tumour cell proliferation on large, consecutive and unselected series of human tumours.	Paraffin	168-176	MIB E3 ubiquitin protein ligase 1	Homo sapiens	51-56
9375023-5	1997	The median values of MIB-1 indices were markedly lower in Bouin-fixed, paraffin embedded, and in frozen samples (20.0% and 19.8%, respectively), with a poor correlation coefficient with the values detected following formalin fixation (R2 = 0.456).	Paraffin	71-79	MIB E3 ubiquitin protein ligase 1	Homo sapiens	21-26
9066700-1	1997	The MIB1 monoclonal antibody which is used as a marker of cell proliferation was studied by immunohistochemistry on formalin-fixed and paraffin embedded biopsy specimens of lymph nodes in 40 high- and 46 lowgrade cases of non-Hodgkin"s lymphomas (NHL) classified according to the Kiel classification.	Paraffin	135-143	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-8
9260591-4	1997	The expression of the proteins p53 and mdm2 was determined immunohistochemically using formalin-fixed, paraffin-embedded material.	Paraffin	103-111	MDM2 proto-oncogene	Homo sapiens	39-43
8902095-3	1996	We have immunohistochemically investigated the distribution of CD44 in paraffin-embedded samples of 41 benign and malignant sweat gland tumors by using a monoclonal antibody directed against the standard isoform of CD44.	Paraffin	71-79	CD44 molecule (Indian blood group)	Homo sapiens	63-67
8938590-3	1996	Hybridisation histochemistry was used to detect transcription of PTHrP and PTH in serial paraffin sections through the 12.5- and 13.5-day rat embryo parathyroid anlage, as well as in sections through the 17.5-day embryonic and adult parathyroid glands.	Paraffin	89-97	parathyroid hormone-like hormone	Rattus norvegicus	65-70
8675992-3	1996	We assessed the immunohistochemical expression of proliferating cell nuclear antigen (PCNA) in paraffin-embedded tissues, using monoclonal antibody PC 10 against PCNA combined with immunogold-silver staining.	Paraffin	95-103	proliferating cell nuclear antigen	Rattus norvegicus	50-84
8675992-3	1996	We assessed the immunohistochemical expression of proliferating cell nuclear antigen (PCNA) in paraffin-embedded tissues, using monoclonal antibody PC 10 against PCNA combined with immunogold-silver staining.	Paraffin	95-103	proliferating cell nuclear antigen	Rattus norvegicus	86-90
9156521-6	1996	We have shown clear amplification of VDR transcripts within sections of formalin-fixed paraffin-embedded human kidney and liver.	Paraffin	87-95	vitamin D receptor	Homo sapiens	37-40
8634086-1	1996	Point mutations of the Ki-ras and p53 genes in rat lung lesions induced by N-nitrosobis(2-hydroxypropyl)amine (BHP) were investigated by polymerase chain reaction-single strand conformation polymorphism analysis followed by direct sequencing using paraffin-embedded tissues.	Paraffin	248-256	KRAS proto-oncogene, GTPase	Rattus norvegicus	23-29
8857669-0	1996	Monoclonal antibody MAT-1 against human tyrosinase can detect melanogenic cells on formalin-fixed paraffin-embedded sections.	Paraffin	98-106	tyrosinase	Homo sapiens	40-50
9431695-0	1996	Immunoreactivity of new antibodies anti-p53 and anti-MDM-2 in paraffin embedded tissue samples.	Paraffin	62-70	MDM2 proto-oncogene	Homo sapiens	53-58
9431695-1	1996	Detection of various epitopes of the p53 and MDM-2 proteins, using new antibodies was performed on formalin-fixed and paraffin-embedded tissue samples from breast cancer and compared with results obtained using well-characterized antibodies.	Paraffin	118-126	MDM2 proto-oncogene	Homo sapiens	45-50
9816101-2	1996	The MIB-1 antibody detects the Ki-67 antigen in microwave-processed paraffin sections of the formalin-fixed tumors.	Paraffin	68-76	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-9
8541732-0	1995	Analysis of K-ras gene mutations in periampullary cancers, gallbladder cancers and cholangiocarcinomas from paraffin-embedded tissue sections.	Paraffin	108-116	KRAS proto-oncogene, GTPase	Homo sapiens	12-17
8541732-2	1995	DNA extracted from the paraffin-embedded tissues was amplified with the polymerase chain reaction and subsequently analyzed by direct cycle sequencing at codons 12, 13 and 18 of the K-ras gene.	Paraffin	23-31	KRAS proto-oncogene, GTPase	Homo sapiens	182-187
8669852-12	1995	CONCLUSIONS: Such results indicate that the detection of proliferative activity on paraffin sections with MIB-1 monoclonal antibody provides in formation analogous to or even better than that obtained with Ki-67 antibody on frozen ones.	Paraffin	83-91	MIB E3 ubiquitin protein ligase 1	Homo sapiens	106-111
8835134-1	1995	MiB-1 antibody staining can be carried out on formalin fixed, paraffin embedded tissue only if microwave antigen retrieval is performed.	Paraffin	62-70	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
8731840-1	1995	Hepatitis C virus antigen (HCV Ag) and HCV-NS3 protein in paraffin-embedded liver tissue of patients with HCV infection were detected with immunohistochemical method by using polyclonal anti-HCV and monoclonal anti-HCV-NS3 for studying the expression of HCV in liver tissue.	Paraffin	58-66	KRAS proto-oncogene, GTPase	Homo sapiens	43-46
7572794-15	1995	Both B-LBL/ALL and myeloid sarcomas were often CD45- on paraffin sections, which may be a obstacle in determining the diagnosis.	Paraffin	56-64	protein tyrosine phosphatase receptor type C	Homo sapiens	47-51
16696021-4	1995	Results from gel electrophoretic analysis were compared with ELISA results.Results-The assay proved reliable in detecting K-ras mutations in DNA extracted from both fresh and paraffin embedded colorectal tumours.	Paraffin	175-183	KRAS proto-oncogene, GTPase	Homo sapiens	122-127
7547391-3	1995	Paraffin sections were used for in situ hybridization study with riboprobes transcribed from human CRABP II cDNA.	Paraffin	0-8	cellular retinoic acid binding protein 2	Homo sapiens	99-107
7562249-5	1995	The proliferative activity was estimated using a Ki-67 equivalent monoclonal antibody (MIB-1), which is applicable on formalin-fixed, paraffin-embedded tissue after microwave pretreatment.	Paraffin	134-142	MIB E3 ubiquitin protein ligase 1	Homo sapiens	87-92
7577754-10	1995	Thus, PC10 and MIB-1, applied with care, can be correlated with S phase fraction in paraffin processed tissue sections of breast carcinomas.	Paraffin	84-92	MIB E3 ubiquitin protein ligase 1	Homo sapiens	15-20
7654034-4	1995	In this study the immunohistochemical detection of the MDM2 protein in 186 paraffin embedded tissue sections of normal mucosa, premalignant, malignant and metastatic lesions of the oropharyngeal mucosa is reported for the first time.	Paraffin	75-83	MDM2 proto-oncogene	Homo sapiens	55-59
7567798-3	1995	In this study, the localization of immunoreactive AR was examined in paraformaldehyde-glutaraldehyde fixed, paraffin-embedded human placentae and decidua obtained at various stages from 11 weeks to term pregnancy using the avidin-biotin complex/peroxidase method.	Paraffin	108-116	amphiregulin	Homo sapiens	50-52
9816002-3	1995	We studied 37 patients who received chemotherapy with 5-fluorouracil and leucovorin, Exon 1 of the c-K-ras gene was PCR amplified from DNA extracted from paraffin-embedded tumor blocks.	Paraffin	154-162	KRAS proto-oncogene, GTPase	Homo sapiens	99-106
7850711-2	1995	BACKGROUND: MIB-1 was found to be detectable in formalin fixed, paraffin embedded materials with microwave treatment using Ki-67 monoclonal antibody, and immunostaining has been widely documented as a useful marker of proliferation.	Paraffin	64-72	MIB E3 ubiquitin protein ligase 1	Homo sapiens	12-17
8600679-3	1995	We have evaluated the expression of CD44 standard (CD44s) and variant exons (CD44v) encoded gene products in formalin-fixed and paraffin-embedded human liver specimens, using an immunohistochemical protocol with microwave-based antigen-retrieval and signal amplification.	Paraffin	128-136	CD44 molecule (Indian blood group)	Homo sapiens	36-40
7536376-1	1994	The immunohistochemical staining of vimentin in paraffin-embedded sections from adult cattle, rabbit, rat and mouse brain fixed in different fixatives (formaldehyde, methacarn, ethanol) was examined using two monoclonal antibodies and a polyclonal antiserum.	Paraffin	48-56	vimentin	Bos taurus	36-44
7884589-8	1994	It appears that Ki-67 (MIB-1) immunolabelling using archival paraffin-embedded samples is of value in predicting prognosis in astrocytic tumours.	Paraffin	61-69	MIB E3 ubiquitin protein ligase 1	Homo sapiens	23-28
7524307-0	1994	Terminal deoxynucleotidyl transferase staining in acute leukemia and normal bone marrow in routinely processed paraffin sections.	Paraffin	111-119	DNA nucleotidylexotransferase	Homo sapiens	0-37
7873736-1	1994	The vitamin D-receptor protein and its mRNA were localized in microscope sections of paraffin-embedded mammalian kidneys by means of immunocytochemistry and in situ hybridization, respectively.	Paraffin	85-93	vitamin D receptor	Homo sapiens	4-22
7521787-1	1994	BACKGROUND: Recently, it has been shown that heating paraffin embedded tumor sections in a microwave oven can reactivate an epitope of Ki-67 protein that is recognized by the monoclonal antibody MIB-1.	Paraffin	53-61	MIB E3 ubiquitin protein ligase 1	Homo sapiens	195-200
7532653-3	1994	In this study, we investigated tenascin expression in 70 benign, dysplastic and malignant melanocytic tumors by using immunohistochemistry and monoclonal anti-tenascin 143DB7C8 antibody on paraffin sections.	Paraffin	189-197	tenascin C	Homo sapiens	31-39
7961123-1	1994	We have examined the occurrence of apoptotic cell death in formalin-fixed, paraffin-embedded human gastric carcinoma specimens by the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method.	Paraffin	75-83	DNA nucleotidylexotransferase	Homo sapiens	173-176
7987679-5	1994	PCNA-immunostaining was performed on paraffin sections to determine the number of proliferating cells.	Paraffin	37-45	proliferating cell nuclear antigen	Rattus norvegicus	0-4
7965394-0	1994	Production of two monoclonal antibodies (FB1 and FB21) useful for the identification of human B lymphocytes in formalin-fixed, paraffin-embedded tissues.	Paraffin	127-135	TCF3 fusion partner	Homo sapiens	41-44
7965394-1	1994	Two monoclonal antibodies (FB1 and FB21) reactive in formalin-fixed, paraffin-embedded tissue sections are reported in this paper.	Paraffin	69-77	TCF3 fusion partner	Homo sapiens	27-30
7913577-10	1994	Both p53 protein and p185 antibodies work well on routine, formalin-fixed, paraffin-embedded tissue and are easily used in routine diagnostic procedures.	Paraffin	75-83	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	21-25
7928052-1	1994	The proliferative activity of invasive squamous cell carcinoma of the vulva was examined using a Ki-67 equivalent monoclonal antibody (MIB1), which gives a strong immunoreaction in paraffin-embedded tissue.	Paraffin	181-189	MIB E3 ubiquitin protein ligase 1	Homo sapiens	135-139
7517967-4	1994	In formalin-fixed and paraffin-embedded sections of rat brain, uMtCK immunostaining is detected in the somata of all Golgi type I neurons in the cerebellum, pontine reticular formation, red nucleus, hippocampus, and cerebral cortex.	Paraffin	22-30	creatine kinase, mitochondrial 1	Rattus norvegicus	63-68
8137547-3	1994	In this study we investigated the immunohistological distribution of CD45 isoforms of T cells in 29 paraffin-embedded sarcoid lesions in mediastinal and open lung biopsies.	Paraffin	100-108	protein tyrosine phosphatase receptor type C	Homo sapiens	69-73
7817711-1	1994	Determination of bcr-abl rearrangement in paraffin-embedded tumors using the polymerase chain reaction.	Paraffin	42-50	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	17-24
8091951-6	1994	The close correlation between the BrdUrd LI and Ki-67 protein PCIs in corresponding regions of glioblastomas suggests that MIB 1 staining of microwave-processed paraffin sections can be used to evaluate the growth potential of individual glioblastomas and possibly of other gliomas as well.	Paraffin	161-169	MIB E3 ubiquitin protein ligase 1	Homo sapiens	123-128
7910096-0	1994	Detection of c-Ki-ras gene mutation in paraffin sections of adenocarcinoma and atypical bronchioloalveolar cell hyperplasia of human lung.	Paraffin	39-47	KRAS proto-oncogene, GTPase	Homo sapiens	13-21
7912188-2	1993	Proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, and bromodeoxyuridine (BrdU), an exogenously administered DNA precursor label, were detected in formalin-fixed, paraffin-embedded tissues using immunohistochemical techniques.	Paraffin	194-202	proliferating cell nuclear antigen	Rattus norvegicus	36-40
8101229-5	1993	Using an immunoperoxidase technique, we stained archival formalin-fixed, paraffin-embedded tissue sections with a monoclonal antibody to the 185-kilodalton protein product (p185) of the HER-2/neu gene.	Paraffin	73-81	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	173-177
8406390-1	1993	A total of 118 biopsies from 20 different types of benign, malignant and reactive vascular proliferations were examined for the expression of the CD30 antigen using the monoclonal antibodies BerH2 and HRS4 on paraffin-embedded sections.	Paraffin	209-217	TNF receptor superfamily member 8	Homo sapiens	146-150
8347260-8	1993	The method used suggests that immunohistochemistry for parvalbumin assisted by image analysis is a feasible technique to separate fast- and slow-twitch skeletal muscle fibers in paraffin sections and to characterize their morphologic profiles.	Paraffin	178-186	parvalbumin	Rattus norvegicus	55-66
8481021-4	1993	We investigated the use of one monoclonal antibody (32-2B) to desmoglein 1 on paraffin sections.	Paraffin	78-86	desmoglein 1	Homo sapiens	62-74
8244195-0	1993	Human papilloma virus infection and Ki-ras oncogene in paraffin-embedded squamous carcinomas of the cervix.	Paraffin	55-63	KRAS proto-oncogene, GTPase	Homo sapiens	36-42
7511294-1	1993	We have investigated, by immunohistochemical staining of various paraffin-embedded carcinoma sections, the tissue-specific expression of uroplakin III--a recently characterized constituent glycoprotein (47 kD) of the asymmetrical unit membrane which forms plaques on apical surface of urothelial umbrella cells.	Paraffin	65-73	uroplakin 3A	Homo sapiens	137-150
1364264-1	1992	Monoclonal antibodies to the extracellular domain of the c-erbB-2 oncoprotein (p185) react with routinely processed, paraffin-embedded human tissues, and positive staining with these reagents has been shown to correlate with gene overexpression.	Paraffin	117-125	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	79-83
2698740-7	1989	In PLP-fixed paraffin sections of the kidney, skeletal muscle, and small intestine, all basement membranes were stained intensely by this antibody (JK-199) at the expected locations.	Paraffin	13-21	proteolipid protein 1	Homo sapiens	3-6
2661407-1	1989	A panel of paraffin effective antibodies recognizing B cells and T cells (LN-2, MB1, L26, MT1, UCHL1, kappa, lambda) was used to characterize the immunophenotypes of 26 sinonasal non-Hodgkin"s lymphomas.	Paraffin	11-19	ribosomal protein L26	Homo sapiens	85-88
1442931-3	1992	RESULTS: An apparent somatic mutation of Ki-ras codon 12 in one of 10 paraffin-embedded tumors was confirmed by deoxyribonucleic acid sequence analysis.	Paraffin	70-78	KRAS proto-oncogene, GTPase	Homo sapiens	41-47
2652117-2	1989	The distribution of b2-m immunoreactivity in biopsy material (paraffin sections) of 34 patients with renal transplantation was examined.	Paraffin	62-70	major histocompatibility complex, class I, G	Homo sapiens	20-24
1477938-2	1992	Additionally, c-Ki-ras gene point mutation were also detected in the paraffin embedded sections collected from 34 cases of surgical specimens resected due to pancreatic adenocarcinoma.	Paraffin	69-77	KRAS proto-oncogene, GTPase	Homo sapiens	14-22
2554480-1	1989	Monoclonal antibody KH2 (IgM) reactive with lactosyl ceramide and neolactotetraosyl ceramide was applied for the first time to the staining of human cancerous and noncancerous tissues which were fixed with formalin and embedded in paraffin.	Paraffin	231-239	potassium voltage-gated channel modifier subfamily G member 1	Homo sapiens	20-23
1314130-5	1992	Using polymerase chain reaction-mediated DNA amplification from paraffin-embedded tissues and subsequent DNA sequence analysis, an activating point mutation was detected in the K-ras protooncogene in one tumor.	Paraffin	64-72	KRAS proto-oncogene, GTPase	Homo sapiens	177-182
1590733-3	1992	Amplification of exon 13 of the beta MHC from paraffin-embedded myocardium using the polymerase chain reaction (PCR) was performed and analysis of the amplified product for migration abnormalities using denaturing gradient gel electrophoresis (DGGE) and direct sequencing of the PCR product were used.	Paraffin	46-54	major histocompatibility complex, class I, C	Homo sapiens	37-40
3276902-4	1988	In contrast to mutational activation of ras genes, enhanced expression of p21 was observed in all tumors examined by immunohistochemical techniques with the use of Formalin-fixed paraffin-embedded tissue sections and an anti-ras p21 antibody, RAP-5.	Paraffin	179-187	KRAS proto-oncogene, GTPase	Rattus norvegicus	74-77
1728194-9	1992	In both cases, paraffin section immunohistochemistry revealed reactivity of tumor cells for CD45RB (LCA), CD45RO (A6), CD68 (KP1), CD15 (LeuM1), and lysozyme.	Paraffin	15-23	protein tyrosine phosphatase receptor type C	Homo sapiens	92-96
3280705-1	1988	c-Ki-ras-2 sequences were visualized in paraffin embedded sections from normal adult human pancreases and 24 carcinomas of pancreas by an in situ hybridization technique.	Paraffin	40-48	KRAS proto-oncogene, GTPase	Homo sapiens	0-8
1286726-0	1992	The monoclonal antibody (MAB) CD 68 allows the immunocytochemical identification of macrophages in primary and metastatic brain tumors in paraffin embedded tissues.	Paraffin	138-146	CD68 molecule	Homo sapiens	30-35
3266335-2	1988	The monoclonal antibodies LN1, LN2, and L26 have been recently developed to recognize B-cell-specific antigens that survive routine tissue processing and paraffin embedding.	Paraffin	154-162	ribosomal protein L26	Homo sapiens	40-43
3266335-6	1988	Each of the antibodies marked a small percentage of paraffin-embedded T-cell lymphomas: L26, 4.7%; LN1, 4.7%; LN2, 7.1%.	Paraffin	52-60	ribosomal protein L26	Homo sapiens	88-91
3322020-6	1987	The authors recently investigated a monoclonal antibody (L26) that demonstrates excellent specificity and sensitivity for B lymphocytes, and tumors derived from them, in formalin- and B5-fixed, paraffin-embedded tissue.	Paraffin	194-202	ribosomal protein L26	Homo sapiens	57-60
1497802-5	1992	Paraffin sections of 11 squamous cell carcinomas of the cheek pouch were used to detect mutated Ha-ras alleles.	Paraffin	0-8	Harvey rat sarcoma virus oncogene	Mus musculus	96-102
3327455-2	1987	The previously described monoclonal antibody Myc1-9E10 (1) which recognizes the p62 c-myc protein was used in paraffin tissue sections.	Paraffin	110-118	nucleoporin 62	Homo sapiens	80-83
1746900-1	1991	In the present work, we studied the expression of the c-myc oncoprotein p-62 and the ras oncoprotein p-21 in the dermal cellular infiltrate of paraffin embedded skin specimens, obtained from patients suffering from Mycosis Fungoides and Sezary syndrome.	Paraffin	143-151	nucleoporin 62	Homo sapiens	72-76
3309048-5	1987	CD4 and CD8 antigen preservation in paraffin sections required critical optimal tissue handling.	Paraffin	36-44	CD8a molecule	Homo sapiens	8-11
1855543-6	1991	Vimentin was abundant in the reticular meshwork as positive staining was seen both in frozen and paraffin sections.	Paraffin	97-105	vimentin	Bos taurus	0-8
3797988-6	1986	All mabs have been found suitable for immunohistochemical localization of hTTR even in formaldehyde fixed and paraffin embedded tissues.	Paraffin	110-118	transthyretin	Homo sapiens	74-78
1918508-4	1991	As an example, we detail the detection of a point mutation at codon 61 of the human N-ras gene in DNA from a formalin-fixed paraffin-embedded malignant melanoma specimen.	Paraffin	124-132	NRAS proto-oncogene, GTPase	Homo sapiens	84-89
3531656-0	1986	Immunofluorescence for IgG and C3 in the swine kidney with trypsin-treated paraffin section: the influence of condition of formalin-fixation.	Paraffin	75-83	IGG	Sus scrofa	23-26
1707090-1	1991	Sequential immunocytochemical double labeling of glial fibrillary acidic protein (GFAP) and transferrin (Tf) was used for the simultaneous identification of astrocytes and oligodendrocytes in paraffin-embedded sections of the rat brain.	Paraffin	192-200	glial fibrillary acidic protein	Rattus norvegicus	49-80
1707090-1	1991	Sequential immunocytochemical double labeling of glial fibrillary acidic protein (GFAP) and transferrin (Tf) was used for the simultaneous identification of astrocytes and oligodendrocytes in paraffin-embedded sections of the rat brain.	Paraffin	192-200	glial fibrillary acidic protein	Rattus norvegicus	82-86
3531106-2	1986	The immunohistochemical localization of neuropeptide Y (NPY) was correlated with those of dopamine-beta-hydroxylase (DBH) and vasoactive intestinal polypeptide (VIP) by mapping serial 7 micron paraffin sections at three levels of the guinea pig lower brainstem: a) area postrema, b) dorsal motor nucleus of the vagus, and c) nucleus prepositus of the hypoglossal nerve.	Paraffin	193-201	pro-neuropeptide Y	Cavia porcellus	40-54
1902452-1	1991	The presence of point mutation at codons 12, 13 and 61 of the c-Ki-ras oncogene was investigated in 7 cases of gastric adenoma and 35 cases of gastric adenocarcinoma using DNA samples from formalin-fixed and paraffin-embedded tissues.	Paraffin	208-216	KRAS proto-oncogene, GTPase	Homo sapiens	62-70
1779136-1	1991	The peroxidase-antiperoxidase (PAP) method was used on paraffin embedded tissue to demonstrate the presence of the glial fibrillary acidic protein (GFAP) in sensory ganglia of kittens, cats and toads.	Paraffin	55-63	glial fibrillary acidic protein	Felis catus	148-152
2858057-3	1985	We describe here the relationship between cortical somatostatin immunoreactivity and the plaques and tangles of diseased tissue by immunocytochemical and silver impregnation techniques on paraffin-embedded tissue.	Paraffin	188-196	somatostatin	Homo sapiens	51-63
3883035-1	1985	The Ca1 monoclonal antibody was used to detect Ca antigen in paraffin sections with the use of a two-stage indirect immunoperoxidase technique.	Paraffin	61-69	carbonic anhydrase 1	Homo sapiens	4-7
2085506-1	1990	We have used a monoclonal antibody against human pancreatic lipase to study the immunohistochemical expression of lipase in formalin-fixed, paraffin-embedded biopsy specimens from normal and a variety of tumoral and inflammatory skin diseases.	Paraffin	140-148	pancreatic lipase	Homo sapiens	49-66
6083466-0	1984	Myelin basic protein in the optic nerve of the developing albino rat: an immunoperoxidase study of paraffin embedded tissue.	Paraffin	99-107	myelin basic protein	Rattus norvegicus	0-20
2075914-4	1990	Uteroferrin was detected in the apical and basolateral cytoplasm of trophectoderm by immunocytochemistry of paraffin-embedded blastocysts.	Paraffin	108-116	acid phosphatase 5, tartrate resistant	Sus scrofa	0-11
6083466-1	1984	The distribution of myelin basic protein (MBP) was determined by application of the unlabeled peroxidase-anti-peroxidase method to sections of paraffin embedded optic nerve taken from the developing albino rat.	Paraffin	143-151	myelin basic protein	Rattus norvegicus	20-40
6083466-1	1984	The distribution of myelin basic protein (MBP) was determined by application of the unlabeled peroxidase-anti-peroxidase method to sections of paraffin embedded optic nerve taken from the developing albino rat.	Paraffin	143-151	myelin basic protein	Rattus norvegicus	42-45
2088481-6	1990	Conditions are described for use of HCA2 and HC10 in immunohistochemical staining of formalin-fixed, paraffin-embedded sections.	Paraffin	101-109	MAGE family member C3	Homo sapiens	36-40
6177989-1	1982	The Ca1 antibody has been used in an immunohistochemical procedure to detect the Ca antigen in sections of tissues routinely embedded in paraffin wax.	Paraffin	137-149	carbonic anhydrase 1	Homo sapiens	4-7
7050239-9	1982	It is concluded that pAg and pA-silver complexes are useful as general second step reagents for the localization of a variety of antigens in paraffin sections.	Paraffin	141-149	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	Homo sapiens	21-24
34521010-5	2021	Immunofluorescence staining of paraffin sections of embryonic days 13.5 and 14.5 Setdb1 conditional knockout mice or transfected ATDC5 cells was performed to detect PTH/PTHrP receptor.	Paraffin	31-39	parathyroid hormone 1 receptor	Mus musculus	165-183
34707964-3	2021	Methods The MMP-9 expression in gastric cancer was identified by immunohistochemistry using a monoclonal antibody in paraffin-embedded sections, correlated with various clinicopathological parameters, and statistically analyzed.	Paraffin	117-125	matrix metallopeptidase 9	Homo sapiens	12-17
7044402-4	1982	TdT cells can be identified in formalin (but not in Bouin"s or Carnoy"s) fixed paraffin-embedded tissues, and the preservation of morphological details is excellent.	Paraffin	79-87	DNA nucleotidylexotransferase	Homo sapiens	0-3
6281168-1	1982	The distribution of the glial fibrillary acidic protein (GFAP) was investigated in sections of 131 paraffin-embedded brain neoplasms obtained at surgery or at autopsy.	Paraffin	99-107	glial fibrillary acidic protein	Homo sapiens	24-55
34312925-4	2021	CCT6A protein expression was determined in the tumor tissues fixed in formalin and embedded in paraffin (FFEP) by immunohistochemistry (IHC) assay.	Paraffin	95-103	chaperonin containing TCP1 subunit 6A	Homo sapiens	0-5
34179706-9	2021	Results: The levels of DCX and CRABP2 were confirmed to be remarkably different between paraffin-embedded ARMS and ERMS tissues, while EGFR abundance was only marginally different between these two RMS subtypes.	Paraffin	88-96	cellular retinoic acid binding protein 2	Homo sapiens	31-37
6281168-1	1982	The distribution of the glial fibrillary acidic protein (GFAP) was investigated in sections of 131 paraffin-embedded brain neoplasms obtained at surgery or at autopsy.	Paraffin	99-107	glial fibrillary acidic protein	Homo sapiens	57-61
24232516-2	1980	Exposure of the alga to paraffins for 10 days results in accumulation of n-alkanes having between C13 and C16 carbon atoms.	Paraffin	24-33	homeobox C13	Homo sapiens	98-101
35616135-3	2022	The expression of MSLN in human TNBC paraffin sections was analyzed by immunohistochemistry.	Paraffin	37-45	mesothelin	Homo sapiens	18-22
35574323-7	2022	Protein expression of N-CAD was studied in 117 formalin-fixed and paraffin-embedded (FFPE) blocks from patients diagnosed with OC using Tissue Microarray and immunohistochemistry techniques.	Paraffin	66-74	cadherin 2	Homo sapiens	22-27
32857249-3	2021	We carried out a preliminary evaluation of MYB-NFIB translocation by fluorescence in-situ hybridization on seven archived formalin-fixed paraffin-embedded tissues of AdCC of Nigerian patients and its clinicopathologic features.	Paraffin	137-145	nuclear factor I B	Homo sapiens	47-51
33907580-4	2021	The expression level and subcellular localization of LACTB and LC3 in paraffin-embedded biopsies were detected by immunohistochemistry and immunofluorescence.	Paraffin	70-78	lactamase beta	Homo sapiens	53-58
35462576-3	2022	In our study, high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1 (NUPR1) as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.	Paraffin	174-182	nuclear protein 1, transcriptional regulator	Homo sapiens	84-101
35462576-3	2022	In our study, high-sensitivity label-free quantitative proteomics analysis revealed nuclear protein 1 (NUPR1) as the most significantly upregulated protein in formalin-fixed paraffin-embedded tumour samples derived from OSCC patients with or without lymphatic metastasis.	Paraffin	174-182	nuclear protein 1, transcriptional regulator	Homo sapiens	103-108
33907580-4	2021	The expression level and subcellular localization of LACTB and LC3 in paraffin-embedded biopsies were detected by immunohistochemistry and immunofluorescence.	Paraffin	70-78	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	63-66
35209344-1	2022	We measured the spin noise spectroscopy (SNS) of rubidium atomic ensemble with two different kinds of atomic vapor cells (filled with buffer gas or coated with paraffin film on the inner wall) and demonstrated the enhancement of the signal-to-noise ratio (SNR) by using polarization squeezed state (PSS) of 795-nm light field with Stokes operator S Lambda 2 squeezed.	Paraffin	160-168	spindlin 1	Homo sapiens	16-20
34013204-3	2021	Here, we performed immunofluorescence labelling of different synaptic proteins in fixed and paraffin-embedded human hippocampal sections and report reduced levels of several presynaptic proteins of the neurotransmitter release machinery (complexin-1, syntaxin-1A, synaptotagmin-1 and synaptogyrin-1) in Alzheimer"s disease cases.	Paraffin	92-100	complexin 1	Homo sapiens	238-249
33848380-4	2021	Here we evaluated the clinical significance of TALDO1 expression in 115 paraffin-embedded tumor samples from patients with UTUC using immunohistochemistry.	Paraffin	72-80	transaldolase 1	Homo sapiens	47-53
33040544-5	2021	A female patient was diagnosed as the left lower lobe adenocarcinoma stage IV (T4N2M1, pleural metastasis) via lung biopsy and was detected wild-type EGFR and 18% ALK gene rearrangement from paraffin section.	Paraffin	191-199	ALK receptor tyrosine kinase	Homo sapiens	163-166
33704740-3	2021	Multiplex immunohistochemistry (mIHC) is a new technology which addresses this issue and enables simultaneous detection of melanoma and multiple immune subsets in formalin fixed paraffin embedded tissue.	Paraffin	178-186	myosin IA	Mus musculus	32-36
33148208-7	2020	The immunohistochemical (IHC) result based on 140 paraffin-embedded human GC samples indicated that ALDH3A2 was over-expressed in low-grade GC cases and the OS of patients with low expression of ALDH3A2 was significantly shorter than those with high ALDH3A2 expression.	Paraffin	50-58	aldehyde dehydrogenase 3 family member A2	Homo sapiens	100-107
33144423-2	2020	A novel mixed histochemical/immunohistochemical method (SenTraGor , STG) detecting lipofuscin accumulation allows the assessment of senescent cells in paraffin-embedded tissue material.	Paraffin	151-159	chromosome 6 open reading frame 15	Homo sapiens	68-71
33119552-4	2020	RESULTS Analysis of the RNA-Seq data from the TCGA (The Cancer Genome Atlas) MIBC cohort (n=408) revealed that CEP78 was overexpressed in tumor tissues, which was confirmed with fresh-frozen and formalin-fixed paraffin-embedded specimens collected from 28 and 33 MIBC patients, respectively, in the present study.	Paraffin	210-218	centrosomal protein 78	Homo sapiens	111-116
32754325-2	2020	Reverse transcription-quantitative PCR was used to quantify the mRNA expression levels of HIF-1alpha, HIF-2alpha, prolyl hydroxylase (PHD)1, PHD2 and PHD3 in formalin-fixed paraffin-embedded (FFPE) tumour tissue samples from 41 patients with RCC, including 33 cases of clear cell RCC (ccRCC).	Paraffin	173-181	egl-9 family hypoxia inducible factor 3	Homo sapiens	150-154
32908618-10	2020	Conclusions: Sox10 is the specific marker for immunohistochemical staining of NCSCs in paraffin sections.	Paraffin	87-95	SRY-box transcription factor 10	Rattus norvegicus	13-18
32903564-4	2020	Somatic BRCA1/2 mutation analysis was performed by next-generation sequencing on the DNA extracted from a formalin-fixed, paraffin-embedded CCA biopsy specimen of their mother.	Paraffin	122-130	BRCA1 DNA repair associated	Homo sapiens	8-15
32553554-4	2020	MATERIALS AND METHODS: We verify ALK expression and rearrangement on formalin-fixed paraffin-embedded tumor samples of the patient by Immunohistochemistry and Fluorescence In Situ Hybridization analysis.	Paraffin	84-92	ALK receptor tyrosine kinase	Homo sapiens	33-36
32774513-7	2020	In the second part of the study, the tissue expression of IL-17 was assessed in archival paraffin-embedded biopsy specimens from CLP (n = 14) against normal control tissues (n = 11) using immunohistochemical assays.	Paraffin	89-97	interleukin 17A	Homo sapiens	58-63
32468256-3	2020	The aim of this study was to evaluate the versatility of the high-resolution melting analysis (HRMA) obtained by magnetic induction cycler (MIC) to monitor the BRCA2 status in formalin-fixed paraffin-embedded (FFPE) tissue samples of this patient and to compare the results obtained by NGTS.	Paraffin	191-199	BRCA2 DNA repair associated	Homo sapiens	160-165
32466184-1	2020	We introduce a machine learning-based analysis to predict the immunohistochemical (IHC) labeling index for the cell proliferation marker Ki67/MIB1 on cancer tissues based on morphometrical features extracted from hematoxylin and eosin (H&E)-stained formalin-fixed, paraffin-embedded (FFPE) tumor tissue samples.	Paraffin	265-273	MIB E3 ubiquitin protein ligase 1	Homo sapiens	142-146
32431549-4	2020	Methods: The protein expression of NUDT21 was examined by immunohistochemistry (IHC) in 100 paraffin-embedded, archived breast cancer samples and 100 benign breast tissues.	Paraffin	92-100	nudix hydrolase 21	Homo sapiens	35-41
31875416-5	2020	Moreover, IHC was used to evaluate IGBP1 expression in archived 190 paraffin-embedded ESCC specimens.	Paraffin	68-76	immunoglobulin binding protein 1	Homo sapiens	35-40
32376554-2	2020	METHODS: RT-qPCR was performed to detect the expression of STAT2 mRNA in 62 fresh frozen ovarian cancer tissues and 62 normal ovarian tissues; immunohistochemistry was used to detect STAT2 protein expressions in 95 paraffin-embedded ovarian cancer samples and 33 normal ovarian tissues.	Paraffin	215-223	signal transducer and activator of transcription 2	Homo sapiens	183-188
31163960-1	2020	Purpose: The aim of this study was to develop a formalin-fixed paraffin-embedded (FFPE) tissue based multiplex immunochemistry (mIHC) method for high-throughput comprehensive tissue imaging and demonstrate its feasibility, validity, and usefulness.	Paraffin	63-71	myosin IA	Mus musculus	128-132
31272054-0	2019	The impact of baking on chlorinated paraffins: Characterization of C10-C17 chlorinated paraffins in oven-baked pastry products and unprocessed pastry dough by HPLC-ESI-Q-TOF-MS.	Paraffin	36-45	chromosome 12 open reading frame 57	Homo sapiens	67-70
31272054-0	2019	The impact of baking on chlorinated paraffins: Characterization of C10-C17 chlorinated paraffins in oven-baked pastry products and unprocessed pastry dough by HPLC-ESI-Q-TOF-MS.	Paraffin	87-96	chromosome 12 open reading frame 57	Homo sapiens	67-70
29727326-5	2019	Germline DNA for BRCA1/2 testing of most-prevalent mutations (covering ~61%) was mainly derived from paraffin-blocks.	Paraffin	101-110	BRCA1 DNA repair associated	Homo sapiens	17-22
31358091-4	2019	METHODOLOGY: Paraffin blocks of diagnosed cases of oral SCC presenting at Pathology Department, KEMU, were selected for immunostain GLUT 1.	Paraffin	13-21	solute carrier family 2 member 1	Homo sapiens	132-138
30865538-4	2019	Immunohistochemical staining for parafibromin was performed on formalin-fixed, paraffin-embedded tissue samples.	Paraffin	79-87	cell division cycle 73	Homo sapiens	33-45
30902772-6	2019	METHODS: KRAS mutation in codon35 (G A, G12D; G T, G12V) was examined by a digital polymerase chain reaction analysis using genome purified from paraffin-embedded slides of human BAVMs.	Paraffin	145-153	KRAS proto-oncogene, GTPase	Homo sapiens	9-13
30997980-3	2019	TRPM2 and TRPM7 genes were analyzed with qRT-PCR in paraffin-embedded  tissue  samples.	Paraffin	52-60	transient receptor potential cation channel subfamily M member 7	Homo sapiens	10-15
30213873-9	2018	We revealed that low levels of miR-150 and high levels of its target, FOXP1, are associated with shorter overall survival in FL and suggest that miR-150 could serve as a good biomarker measurable in formalin-fixed paraffin-embedded tissue.	Paraffin	214-222	microRNA 150	Homo sapiens	145-152
29745967-3	2018	Paraffin embedded tissue with immunohistochemistry methods was adopted to exam PTPRS expression in ESCC and paired normal esophageal mucosa tissues on Tissue Microarrays (TMAs).	Paraffin	0-8	protein tyrosine phosphatase receptor type S	Homo sapiens	79-84
29885401-3	2018	In this study, we have assessed the expression of B7H4 and cancer stemness proteins in 156 paraffin-embedded ESCC tissue samples using immunohistochemistry as well as in ESCC cell lines using Western blotting and immunofluorescence imaging.	Paraffin	91-99	V-set domain containing T cell activation inhibitor 1	Homo sapiens	50-54
29630949-3	2018	To characterize the expression of zebrafish fgfr3 from the larval stage to adulthood, we used RNAscope in situ hybridization on paraffin sections of the zebrafish head.	Paraffin	128-136	fibroblast growth factor receptor 3	Danio rerio	44-49
28766250-5	2018	Seven cases of ASPS mRNA were successfully extracted from nine paraffin-embedded tissues.	Paraffin	63-71	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	15-19
30013444-4	2018	Methods: The expression of PRDX4 and MIB-1, a widely accepted Ki67 protein, was immunohistochemically analysed in 206 paraffin-embedded tumour specimens of patients with stage I-LUAD.	Paraffin	118-126	peroxiredoxin 4	Homo sapiens	27-32
29235112-2	2018	In our retrospective study the expression of Hsp70 was determined in relation to tumor-infiltrating CD56+ NK cells in formalin-fixed paraffin embedded (FFPE) tumor specimens of patients with SCCHN (N = 145) as potential indicators for survival and disease recurrence.	Paraffin	133-141	heat shock protein family A (Hsp70) member 4	Homo sapiens	45-50
29327716-3	2018	Clinically, targeted anti-ALK therapy is often initiated based on evidence of an ALK genomic rearrangement detected by fluorescence in situ hybridization (FISH) of interphase cells in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	200-208	ALK receptor tyrosine kinase	Homo sapiens	26-29
29327716-3	2018	Clinically, targeted anti-ALK therapy is often initiated based on evidence of an ALK genomic rearrangement detected by fluorescence in situ hybridization (FISH) of interphase cells in formalin-fixed, paraffin-embedded tissue sections.	Paraffin	200-208	ALK receptor tyrosine kinase	Homo sapiens	81-84
29434907-4	2018	RACK1 expression levels in paraffin-embedded PDAC tissues were determined by immunohistochemistry.	Paraffin	27-35	receptor for activated C kinase 1	Homo sapiens	0-5
30453285-5	2018	METHODS: The correlation of DCLK1 expression and clinical features of pancreatic cancer was analyzed in 210 paraffin-embedded archived pancreatic cancer specimens by immunohistochemical analysis.	Paraffin	108-116	doublecortin like kinase 1	Homo sapiens	28-33
29682243-7	2018	NRAS mutation analysis was performed on paraffin embedded formalin fixed tissue of these cases by polymerase chain reaction (PCR)-sequencing method.	Paraffin	40-48	NRAS proto-oncogene, GTPase	Homo sapiens	0-4
29259341-0	2017	Impact of the G84E variant on HOXB13 gene and protein expression in formalin-fixed, paraffin-embedded prostate tumours.	Paraffin	84-92	homeobox B13	Homo sapiens	30-36
29016222-3	2017	We re-examined proteomics results from a number of formalin-fixed paraffin-embedded amyloid samples, which were positive for transthyretin (TTR) by immunohistochemistry and proteomics, using the UniProt human protein database modified to include TTR variants.	Paraffin	66-74	transthyretin	Homo sapiens	140-143
29138507-3	2017	We present an mIHC platform combining fluorescent and chromogenic staining with automated whole-slide imaging and integrated whole-slide image analysis, enabling simultaneous detection of six protein markers and nuclei, and automatic quantification and classification of hundreds of thousands of cells in situ in formalin-fixed paraffin-embedded tissues.	Paraffin	328-336	myosin IA	Mus musculus	14-18
28992761-4	2017	One candidate for such test is fully integrated, real-time polymerase chain reaction-based Idylla  system for quick and simple detection of KRAS mutations in formaldehyde fixed-paraffin embedded tumor samples.	Paraffin	177-185	KRAS proto-oncogene, GTPase	Homo sapiens	140-144
28755528-3	2017	In this study, recombinant KLK4 protein was generated and affinity-purified KLK4-directed polyclonal antibody pAb587 established to allow localization of KLK4 protein expression in tumor cell lines and archived formalin-fixed, paraffin-embedded TNBC tumor tissue specimens.	Paraffin	227-235	kallikrein related peptidase 4	Homo sapiens	27-31
28858088-9	2017	Ultimately, PTL was confirmed by paraffin pathological diagnosis.	Paraffin	33-41	pancreatic lipase	Homo sapiens	12-15
28620836-5	2017	We examined the expression of SOX2 on archived paraffin-embedded tissue from pediatric glial tumors.	Paraffin	47-55	SRY-box transcription factor 2	Homo sapiens	30-34
28789449-8	2017	Quantification of TOMM34 and RNF43 gene expression in several-year-old paraffin-embedded colorectal cancer specimens was possible by qPCR using the Universal ProbeLibrary.	Paraffin	71-79	ring finger protein 43	Homo sapiens	29-34
28498805-2	2017	In this study, the impact of FOXM1 expression on patient outcome was investigated for the first time in formalin fixed and paraffin embedded (FFPE) samples of chemotherapy naive muscle-invasive bladder cancer (MIBC) patients.	Paraffin	123-131	forkhead box M1	Homo sapiens	29-34
28748483-3	2017	MicroRNA-146a and microRNA-155 were detected by in situ hybridization with digoxigenin on paraffin sections.	Paraffin	90-98	microRNA 155	Homo sapiens	18-30
28681697-6	2017	Immunohistochemical expression of Tim-3 was examined in our large numbers of paraffin-fixed prostate tissues.	Paraffin	77-85	hepatitis A virus cellular receptor 2	Homo sapiens	34-39
27921164-6	2017	We examined PLA2R glomerular staining in stored, formalin-fixed, paraffin-embedded kidney biopsy samples.	Paraffin	65-73	phospholipase A2 receptor 1	Homo sapiens	12-17
28454236-2	2017	CD30 expression was detected using immunohistochemistry on paraffin-embedded sections obtained from 122 patients with ENKTL prior to treatment.	Paraffin	59-67	TNF receptor superfamily member 8	Homo sapiens	0-4
28234557-0	2017	A Novel Monoclonal Antibody Against Alpha-Methylacyl-CoA Racemase Applicable for Paraffin-Embedded Tissues and Diagnostics of Prostate Cancer.	Paraffin	81-89	alpha-methylacyl-CoA racemase	Homo sapiens	36-65
28234557-6	2017	G8 mAb specifically binds human AMACR and was successfully used in immunoblotting and immunofluorescence on paraformaldehyde-fixed cells and in IHC of paraffin-embedded tumor specimens.	Paraffin	151-159	alpha-methylacyl-CoA racemase	Homo sapiens	32-37
28036291-0	2017	Assessing the clinical value of microRNAs in formalin-fixed paraffin-embedded liposarcoma tissues: Overexpressed miR-155 is an indicator of poor prognosis.	Paraffin	60-68	microRNA 155	Homo sapiens	113-120
27032393-8	2017	SLFN5 expression was also determined by immunohistochemistry in formalin-fixed paraffin-embedded samples from individuals with non-atrophic gastritis, atrophic gastritis, complete IM, incomplete IM, and GC, respectively.	Paraffin	79-87	schlafen family member 5	Homo sapiens	0-5
27688162-6	2016	Expressions of WT-1, gp-100, and MAGE-A3, recognized as chemoresistance-associated peptides (CAP), were confirmed by immunohistochemistry of paraffin-embedded tumor samples.	Paraffin	141-149	MAGE family member A3	Homo sapiens	33-40
27498047-4	2016	METHODS: In this study, the expression of RACK1 was evaluated by Western blot analysis in 8 paired fresh PDAC tissues and immunohistochemistry on 179 paraffin-embedded slices.	Paraffin	150-158	receptor for activated C kinase 1	Homo sapiens	42-47
27151985-6	2016	The expression density of integrin beta3 was determined by immunohistochemistry on paraffin slices.	Paraffin	83-91	integrin beta 3	Mus musculus	26-40
27669982-6	2016	Immunohistochemistry (IHC) was conducted to evaluate TLE3 protein expression in 105 paraffin-embedded, archived human CRC tissues from patients, whose survival data were analyzed with Kaplan-Meier method.	Paraffin	84-92	TLE family member 3, transcriptional corepressor	Homo sapiens	53-57
27454146-0	2016	Benchtop Delivery of Ni(cod)2 using Paraffin Capsules.	Paraffin	36-44	COD2	Homo sapiens	21-29
27472713-4	2016	Immunohistochemical analysis of GRO-alpha protein was performed in 160 formalin-fixed, paraffin-embedded PC tissue samples and 68 control specimens, including 37 matched normal surgical margins and 31 benign pancreatic lesions.	Paraffin	87-95	C-X-C motif chemokine ligand 1	Homo sapiens	32-41
26943652-5	2016	The specific expression and cellular distribution of TTR were also evaluated in 104 paraffin-embedded lung cancer samples and 3 normal lung tissues by immunohistochemistry.	Paraffin	84-92	transthyretin	Homo sapiens	53-56
26643668-2	2016	METHODS: The SP immunohistochemical method was used to detect expression of CCL15 in routinely paraffin-embedded sections from 80 cases of HCC, 80 of adjacent cancerous specimens and 50 of normal liver tissue.	Paraffin	95-103	C-C motif chemokine ligand 15	Homo sapiens	76-81
26916074-3	2016	Herein we show microRNA in situ hybridization for fluorescent detection of miR-211, suitable for paraffin-embedded tissues in 109 primary melanocytic tumors.	Paraffin	97-105	microRNA 211	Homo sapiens	75-82
26577686-6	2016	Immunohistochemistry for PLK-1 in paraffin-embedded tissue from the primary and also from the metastasis.	Paraffin	34-42	polo like kinase 1	Homo sapiens	25-30
27002760-2	2016	METHODS: The expression of ALK protein was first determined in paraffin-embedded tissue specimens (FFPE) from 177 pathologically confirmed SRC patients by Ventana Immunohistochemistry (IHC).	Paraffin	63-71	ALK receptor tyrosine kinase	Homo sapiens	27-30
26998141-5	2016	miR-711 was found to be upregulated in 30 formalin-fixed paraffin-embedded breast cancer tissue samples compared with paired non-cancerous breast tissues (P&lt;0.05).	Paraffin	57-65	microRNA 711	Homo sapiens	0-7
26676972-8	2016	Locked nucleic acid in situ hybridization showed increased staining of miR-15b in formalin-fixed paraffin-embedded sections of aMCL.	Paraffin	97-105	microRNA 15b	Homo sapiens	71-78
26383518-4	2016	Immunohistochemistry was applied to analyze the protein expression level of DCLK1 and Lgr5 in paraffin-embedded CRC tissues.	Paraffin	94-102	doublecortin like kinase 1	Homo sapiens	76-81
26565812-3	2016	Immunohistochemical analysis of 261 paraffin-embedded archived gastric cancer tissues showed that high CISD2 expression was significantly associated with clinical stage, TNM classifications, venous invasion and lymphatic invasion.	Paraffin	36-44	CDGSH iron sulfur domain 2	Homo sapiens	103-108
26585927-4	2016	We developed an anaplastic lymphoma kinase (ALK) protein assay that uses multiplexed selected reaction monitoring (SRM) to quantify absolute amounts of ALK in formalin-fixed paraffin-embedded (FFPE) tumor tissue.	Paraffin	174-182	ALK receptor tyrosine kinase	Homo sapiens	16-42
26585927-4	2016	We developed an anaplastic lymphoma kinase (ALK) protein assay that uses multiplexed selected reaction monitoring (SRM) to quantify absolute amounts of ALK in formalin-fixed paraffin-embedded (FFPE) tumor tissue.	Paraffin	174-182	ALK receptor tyrosine kinase	Homo sapiens	44-47
26585927-4	2016	We developed an anaplastic lymphoma kinase (ALK) protein assay that uses multiplexed selected reaction monitoring (SRM) to quantify absolute amounts of ALK in formalin-fixed paraffin-embedded (FFPE) tumor tissue.	Paraffin	174-182	ALK receptor tyrosine kinase	Homo sapiens	152-155
27072218-5	2016	DNA.sequencing method with PCR amplification from archival paraffin blocks were used for KRAS mutation status analysis.	Paraffin	59-67	KRAS proto-oncogene, GTPase	Homo sapiens	89-93
26384642-5	2015	Using DNA from both tumor and formalin-fixed paraffin-embedded tissues, we demonstrated a high efficiency of TaqMan probes in mono- and multiplex mutation scanning of KRAS, NRAS (codons 12, 13, and 61), and BRAF (codon 600) genes.	Paraffin	45-53	KRAS proto-oncogene, GTPase	Homo sapiens	167-171
26682810-0	2015	Superresolution Imaging of Aquaporin-4 Cluster Size in Antibody-Stained Paraffin Brain Sections.	Paraffin	72-80	aquaporin 4	Homo sapiens	27-38
26682810-3	2015	Here, we developed quantitative superresolution optical imaging methodology to measure AQP4 cluster size in antibody-stained paraffin sections of mouse cerebral cortex and spinal cord, human postmortem brain, and glioma biopsy specimens.	Paraffin	125-133	aquaporin 4	Mus musculus	87-91
26682810-9	2015	Our results demonstrate the utility of superresolution optical imaging for measuring the size of AQP4 supramolecular clusters in paraffin sections of brain tissue and support AQP4 cluster size as a primary determinant of its subcellular distribution.	Paraffin	129-137	aquaporin 4	Homo sapiens	97-101
26788096-6	2015	Follicle-stimulating hormone receptors immunostaining was performed on paraffin sections using the rabbit anti-human FSHR polyclonal antibody raised against a 1-190 amino acid sequence from the human FSHR (sc-13935, Santa Cruz).	Paraffin	71-79	follicle stimulating hormone receptor	Homo sapiens	0-38
26562438-5	2015	RESULTS: Utilizing histochemical stains of paraffin embedded knee joint sections in DUSP1 knockout and wild type female and male mice, we showed similar structural progression of cartilage degeneration associated with OA at 21 months of age.	Paraffin	43-51	dual specificity phosphatase 1	Mus musculus	84-89
26516944-5	2015	Real-time polymerase chain reaction to detect the ASPSCR1-TFE3 fusion transcript on paraffin-embedded tissue blocks has been shown to be more sensitive and specific than detection of TFE3 by immunohistochemical stain.	Paraffin	84-92	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	50-57
26459371-3	2015	MATERIALS AND METHODS: We have analysed the immunohistochemical expression of Twist1 and Snai2, two of the most important transcription factors involved in epithelial to mesenchymal transition, in formalin-fixed paraffin-embedded samples of 23 spontaneous abortive pregnancies, 22 molar pregnancies (10 partial and 12 complete) and 7 term placentas.	Paraffin	212-220	snail family transcriptional repressor 2	Homo sapiens	89-94
26505381-2	2015	Immunohistochemistry (IHC) was employed to measure the expression level of Gli1 and p53 in 85 sets of paraffin-embedded PDAC and corresponding para-carcinoma tissue specimens.	Paraffin	102-110	GLI family zinc finger 1	Homo sapiens	75-79
26461825-6	2015	IL-17A IHC staining was performed using 4 mum paraffin skin sections.	Paraffin	46-54	interleukin 17A	Homo sapiens	0-6
26564508-1	2015	OBJECTIVE: To evaluate the application of immunohistochemistry and fluorescence staining method in the detection of phospholipase A2 receptor (PLA2R) on paraffin section of renal biopsy tissue,and to find an accurate and fast method for the detection of PLA2R in renal tissue.	Paraffin	153-161	phospholipase A2 receptor 1	Homo sapiens	116-141
26564508-1	2015	OBJECTIVE: To evaluate the application of immunohistochemistry and fluorescence staining method in the detection of phospholipase A2 receptor (PLA2R) on paraffin section of renal biopsy tissue,and to find an accurate and fast method for the detection of PLA2R in renal tissue.	Paraffin	153-161	phospholipase A2 receptor 1	Homo sapiens	143-148
25946975-7	2015	A positive correlation was observed between SIRT1 and TAp63 expression in HNSCC tissues, as determined by quantitative reverse transcription-polymerase chain reaction analysis of RNA extracted from formalin-fixed paraffin-embedded biopsy samples.	Paraffin	213-221	sirtuin 1	Homo sapiens	44-49
26240410-0	2015	Detection of p62 on Paraffin Sections by Immunohistochemistry.	Paraffin	20-28	sequestosome 1	Homo sapiens	13-16
26240410-3	2015	This protocol outlines the immunohistochemical detection of the protein p62 (sequestosome-1, encoded by the gene SQSTM1)-an indicator of autophagic degradative activity-in slide-mounted paraffin sections such as bone marrow samples cut by a trephine.	Paraffin	186-194	sequestosome 1	Homo sapiens	72-75
26240410-3	2015	This protocol outlines the immunohistochemical detection of the protein p62 (sequestosome-1, encoded by the gene SQSTM1)-an indicator of autophagic degradative activity-in slide-mounted paraffin sections such as bone marrow samples cut by a trephine.	Paraffin	186-194	sequestosome 1	Homo sapiens	77-91
26240410-3	2015	This protocol outlines the immunohistochemical detection of the protein p62 (sequestosome-1, encoded by the gene SQSTM1)-an indicator of autophagic degradative activity-in slide-mounted paraffin sections such as bone marrow samples cut by a trephine.	Paraffin	186-194	sequestosome 1	Homo sapiens	113-119
24700733-4	2015	IGF-1R expression was examined by immunohistochemistry in paraffin-embedded tumor tissues.	Paraffin	58-66	insulin like growth factor 1 receptor	Homo sapiens	0-6
25825818-6	2015	Paraffin-embedded UA rings were used to localize CBS and CSE proteins by immunofluorescence microscopy.	Paraffin	0-8	cystathionine gamma-lyase	Homo sapiens	57-60
25884558-3	2015	METHODS: STYK1 protein expression in paraffin-embedded CRC specimens was determined immunohistochemically.	Paraffin	37-45	serine/threonine/tyrosine kinase 1	Homo sapiens	9-14
26097596-4	2015	FRZB expression was evaluated by immunohistochemistry in formalin-fixed paraffin embedded (FFPE) primary colon carcinoma and paired hepatic metastasis tissues from 136 patients with liver metastasis from colon carcinoma that underwent hepatic resection.	Paraffin	72-80	frizzled related protein	Homo sapiens	0-4
25789835-4	2015	We evaluated the novel high affinity ALK 1A4 antibody for routine diagnostics in formalin fixed, paraffin-embedded tumor specimens.	Paraffin	97-105	ALK receptor tyrosine kinase	Homo sapiens	37-40
25707853-10	2015	Immunohistochemistry of paraffin-embedded mouse brain at P14 using anti-pY1798 antibody displayed signals at the hilum-side (internal side) of the dentate gyrus of the hippocampus, the RMS, the accessory olfactory bulb and the olfactory bulb in which Girdin expression was detected.	Paraffin	24-32	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	57-60
25430495-2	2015	METHODS: Genomic analysis for KRAS gene mutation was performed on formalin fixed paraffin embedded (FFPE) cancer patient tissue that was dissected using the mesodissection platform.	Paraffin	81-89	KRAS proto-oncogene, GTPase	Homo sapiens	30-34
25433814-2	2015	We used immunohistochemistry to evaluate a polyclonal anti-Btk antibody on formalin-fixed paraffin-embedded tissue blocks.	Paraffin	90-98	Bruton tyrosine kinase	Homo sapiens	59-62
25674493-0	2015	Performance of a novel KRAS mutation assay for formalin-fixed paraffin embedded tissues of colorectal cancer.	Paraffin	62-70	KRAS proto-oncogene, GTPase	Homo sapiens	23-27
25674493-9	2015	All three assays proved to be validated methods for detecting clinically significant KRAS mutations in paraffin-embedded tissue samples.	Paraffin	103-111	KRAS proto-oncogene, GTPase	Homo sapiens	85-89
25640355-4	2015	IGF-1R was highly expressed in human endometrial carcinoma paraffin sections, but IGF-1R and phosphor-protein kinase B/protein kinase B (p-Akt/ Akt) expression was down-regulated after metformin treatment (p&lt;0.05).	Paraffin	59-67	insulin like growth factor 1 receptor	Homo sapiens	0-6
25755751-4	2015	Immunohistochemistry (IHC) was performed to examine FLOT2 protein expression in paraffin-embedded tissues from 90 NSCLC patients.	Paraffin	80-88	flotillin 2	Homo sapiens	52-57
25755756-3	2015	We quantified promoter methylation of MGMT using pyrosequencing on paraffin-embedded fine needle aspiration biopsy tissues from 43 glioblastoma.	Paraffin	67-75	O-6-methylguanine-DNA methyltransferase	Homo sapiens	38-42
25060070-3	2015	METHODS: In this study, we examined LSD1 expression in paraffin-embedded CRC specimens from 295 patients, including 65 patients with paired samples of colorectal carcinoma, adjacent adenoma and normal colorectal tissues.	Paraffin	55-63	lysine demethylase 1A	Homo sapiens	36-40
25958733-0	2015	[Simultaneous demonstration of glutamate decarboxylase and synaptophysin in paraffin sections of rat cerebellum].	Paraffin	76-84	glutamate-ammonia ligase	Rattus norvegicus	31-54
25958733-0	2015	[Simultaneous demonstration of glutamate decarboxylase and synaptophysin in paraffin sections of rat cerebellum].	Paraffin	76-84	synaptophysin	Rattus norvegicus	59-72
25566506-3	2014	We have recently developed an FA triple-staining immunofluorescence based method (FATSI) to evaluate FANCD2 foci formation in formalin fixed paraffin-embedded (FFPE) tumor samples.	Paraffin	141-149	FA complementation group D2	Homo sapiens	101-107
25416048-3	2014	To address this problem, immunohistochemistry was performed to detect the expression and the subcellular localization of PDK1 protein in 120 paired of formalin-fixed and paraffin-embedded cancerous and adjacent non-cancerous tissues.	Paraffin	170-178	3-phosphoinositide dependent protein kinase 1	Homo sapiens	121-125
25238939-8	2014	Moreover, RT-PCR using formalin-fixed, paraffin-embedded tissue from the right lung cancer also demonstrated EML4-ALK variant 1 fusion gene.	Paraffin	39-47	EMAP like 4	Homo sapiens	109-113
25238939-8	2014	Moreover, RT-PCR using formalin-fixed, paraffin-embedded tissue from the right lung cancer also demonstrated EML4-ALK variant 1 fusion gene.	Paraffin	39-47	ALK receptor tyrosine kinase	Homo sapiens	114-117
25156059-4	2014	METHODS: YWHAZ expression was assessed by immunohistochemistry on formalin-fixed paraffin-embedded tissue from 213 men who underwent radical prostatectomy.	Paraffin	81-89	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	Homo sapiens	9-14
25054018-5	2014	Paraffin-embedded blocks underwent immunohistochemistry staining, which was performed using vimentin (to assess the evolution of the EMT process), Ki-67 (for evaluation of tumor proliferation) and cluster of differentiation 34 (CD34) (for evaluation of angiogenesis) antibodies.	Paraffin	0-8	CD34 molecule	Canis lupus familiaris	228-232
25134919-6	2014	Immunohistochemistry was performed to examine CISD2 protein expression in paraffin-embedded tissues from 149 early-stage cervical cancer patients.	Paraffin	74-82	CDGSH iron sulfur domain 2	Homo sapiens	46-51
24359286-5	2014	METHODS: We measured NRP2 gene expression in a panel of formalin-fixed paraffin-embedded tissue specimens consisting of naevi, primary melanomas and metastatic melanomas using quantitative reverse transcriptase-polymerase chain reaction technique.	Paraffin	71-79	neuropilin 2	Homo sapiens	21-25
26150933-0	2014	Determining methylation status of methylguanine DNA methyl transferase (MGMT) from formalin-fixed, paraffin embedded tumor tissue.	Paraffin	99-107	O-6-methylguanine-DNA methyltransferase	Homo sapiens	34-70
26150933-0	2014	Determining methylation status of methylguanine DNA methyl transferase (MGMT) from formalin-fixed, paraffin embedded tumor tissue.	Paraffin	99-107	O-6-methylguanine-DNA methyltransferase	Homo sapiens	72-76
24770339-3	2014	METHODOLOGY: The expression of Numb was detected in 107 cases of clinical paraffin-embedded hepatocellular carcinoma tissues,5 matched paris of fresh tissues and six hepatocellular cell lines by immunohistochemistry with clinicopathological analyses,RT-PCR or Western blot.	Paraffin	74-82	NUMB endocytic adaptor protein	Homo sapiens	31-35
25119009-7	2014	With the present study and based on our previous experience we would like to suggest the NUCKS protein as a novel proliferation marker for immunohistochemical evaluation of formalin-fixed and paraffin-embedded skin tumor specimens.	Paraffin	192-200	nuclear casein kinase and cyclin dependent kinase substrate 1	Homo sapiens	89-94
24587207-7	2014	REG-1 immunohistochemistry was performed on paraffin sections with a monoclonal anti-rat REG-1 antibody.	Paraffin	44-52	regenerating family member 1 alpha	Rattus norvegicus	0-5
24398760-2	2014	METHOD: The presence of VEGF and MMP-9 proteins in paraffin-embedded tumour specimens from patients with glioma was detected using immunohistochemistry.	Paraffin	51-59	matrix metallopeptidase 9	Homo sapiens	33-38
24451139-5	2014	In order to explain this overexpression, we investigated the possible association of polymorphisms in the GPER gene by using allele-specific tetra-primer polymerase chain reaction performed on tissue samples from 150 paraffin-embedded TGCT specimens (131 seminomas, 19 non seminomas).	Paraffin	217-225	G protein-coupled estrogen receptor 1	Homo sapiens	106-110
24998573-4	2014	METHODS: miR-152 expression was detected using real-time quantitative RT-PCR in 89 pairs of HCC formalin-fixed paraffin-embedded and their adjacent tissues.	Paraffin	111-119	microRNA 152	Homo sapiens	9-16
24890145-3	2014	METHODS: SIRT1 protein expression was measured by immunohistochemistry in a paraffin-embedded tissue microarray, including 120 paired colorectal cancer and normal mucosa tissues.	Paraffin	76-84	sirtuin 1	Homo sapiens	9-14
23504291-0	2014	Low ING4 protein expression detected by paraffin-section immunohistochemistry is associated with poor prognosis in untreated patients with gastrointestinal stromal tumors.	Paraffin	40-48	inhibitor of growth family member 4	Homo sapiens	4-8
24527533-2	2014	METHODS: We determined the expressions of Cx26, Cx32 and Cx43 in the paraffin samples from 31 cases of PCa and 23 cases of BPH by SABC immunohistochemical staining, and analyzed the relationship of their expressions with the clinical and pathological parameters of PCa and BPH using the semiquantitative method.	Paraffin	69-77	gap junction protein beta 1	Homo sapiens	48-52
23945257-4	2013	FLOT2 protein expression was analyzed in 171 archived paraffin-embedded breast cancer samples using immunohistochemistry (IHC).	Paraffin	54-62	flotillin 2	Homo sapiens	0-5
23351547-4	2013	Expression of miR-10b in 436 paraffin-embedded cancer tissues was also investigated.	Paraffin	29-37	microRNA 10b	Homo sapiens	14-21
23570797-3	2013	We investigated CD151 expression status by immunohistochemical analysis in paraffin-embedded specimens obtained from 380 patients with surgically resected NSCLCs (245 squamous cell carcinomas [SCCs] and 135 adenocarcinomas [ADCs]) between 1994 and 2001.	Paraffin	75-83	CD151 molecule (Raph blood group)	Homo sapiens	16-21
23947964-4	2013	The "original" signature performed on fresh frozen tissue (70G-FFT) could be further developed to a paraffin-based signature (70G-PAR) to reduce test failures.	Paraffin	100-108	jumping translocation breakpoint	Homo sapiens	130-133
23826080-4	2013	METHODOLOGY: The expression of FBX8 was detected in 120 cases of clinical paraffin-embedded hepatocellular carcinoma tissues, 20 matched pairs of fresh tissues and five hepatocellular carcinoma cell lines by immunohistochemistry with clinicopathological analyses, real-time RT-PCR or Western blot.	Paraffin	74-82	F-box protein 8	Homo sapiens	31-35
23741400-0	2013	Evaluation of ALK rearrangement in Chinese non-small cell lung cancer using FISH, immunohistochemistry, and real-time quantitative RT- PCR on paraffin-embedded tissues.	Paraffin	142-150	ALK receptor tyrosine kinase	Homo sapiens	14-17
23159154-0	2013	YWHAE-FAM22 endometrial stromal sarcoma: diagnosis by reverse transcription-polymerase chain reaction in formalin-fixed, paraffin-embedded tumor.	Paraffin	121-129	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	0-5
23159154-4	2013	We describe here an optimized reverse transcription-polymerase chain reaction assay for detection of YWHAE-FAM22 fusion transcript in formalin-fixed and paraffin-embedded tumor samples.	Paraffin	153-161	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	101-106
23159154-7	2013	The reverse transcription-polymerase chain reaction assay optimized for formalin-fixed and paraffin-embedded samples detected YWHAE-FAM22 fusion transcripts in all 6 YWHAE-FAM22 endometrial stromal sarcomas and none of the 24 non-YWHAE-FAM22 uterine sarcomas.	Paraffin	91-99	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	126-131
23159154-7	2013	The reverse transcription-polymerase chain reaction assay optimized for formalin-fixed and paraffin-embedded samples detected YWHAE-FAM22 fusion transcripts in all 6 YWHAE-FAM22 endometrial stromal sarcomas and none of the 24 non-YWHAE-FAM22 uterine sarcomas.	Paraffin	91-99	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	166-171
23159154-7	2013	The reverse transcription-polymerase chain reaction assay optimized for formalin-fixed and paraffin-embedded samples detected YWHAE-FAM22 fusion transcripts in all 6 YWHAE-FAM22 endometrial stromal sarcomas and none of the 24 non-YWHAE-FAM22 uterine sarcomas.	Paraffin	91-99	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	166-171
23159154-8	2013	These findings show that this reverse transcription-polymerase chain reaction assay is sensitive and specific for detection of YWHAE-FAM22 fusion transcript and can serve as a useful adjunct diagnostic assay to confirm the diagnosis of YWHAE-FAM22 endometrial stromal sarcoma in formalin-fixed and paraffin-embedded tumor samples.	Paraffin	298-306	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	127-132
23159154-8	2013	These findings show that this reverse transcription-polymerase chain reaction assay is sensitive and specific for detection of YWHAE-FAM22 fusion transcript and can serve as a useful adjunct diagnostic assay to confirm the diagnosis of YWHAE-FAM22 endometrial stromal sarcoma in formalin-fixed and paraffin-embedded tumor samples.	Paraffin	298-306	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon	Homo sapiens	236-241
23546539-3	2013	Immunohistochemistry was undertaken to assess the expression patterns of Cdx2 and PTEN in paraffin-embedded specimens of 228 GC patients who had undergone radical D2 gastrostomy with long-term follow-up.	Paraffin	90-98	caudal type homeobox 2	Homo sapiens	73-77
23546539-5	2013	Cdx2 was found in the nuclei of GC cells in 43.4% (99/228) of the paraffin-embedded biopsies.	Paraffin	66-74	caudal type homeobox 2	Homo sapiens	0-4
23400679-0	2013	Comparison of COBAS 4800 KRAS, TaqMan PCR and high resolution melting PCR assays for the detection of KRAS somatic mutations in formalin-fixed paraffin embedded colorectal carcinomas.	Paraffin	143-151	KRAS proto-oncogene, GTPase	Homo sapiens	102-106
23063350-3	2013	This study is the first to show the significant upregulation of ARK5 paraffin-embedded archival glioma biopsies compared with those in adjacent non-cancerous brain tissues.	Paraffin	69-77	NUAK family kinase 1	Homo sapiens	64-68
23484153-5	2013	We assessed ALK fusion status for 95 formalin-fixed paraffin-embedded tumor tissue specimens from 87 patients with NSCLC by FISH and real-time RT-PCR, for 57 specimens from 56 patients by targeted resequencing, and for 14 specimens from 14 patients by IHC.	Paraffin	52-60	ALK receptor tyrosine kinase	Homo sapiens	12-15
23838137-3	2013	METHODS: Direct sequencing was conducted to detect mutations in KRAS codons 12, 13 and 61 using 574 colorectal paraffin embedded clinical samples.	Paraffin	111-119	KRAS proto-oncogene, GTPase	Homo sapiens	64-68
24376306-2	2013	The objective of this study was to examine the immunoexpression of IL-22 and IL-23 in archival paraffin-embedded biopsy specimens from oral LP (n = 42) and cutaneous LP (n = 38) against normal control tissues.	Paraffin	95-103	interleukin 22	Homo sapiens	67-72
23306391-2	2013	METHODS: FASN expression in endometrioid endometrial cancer was assessed by immunohistochemistry using 108 paraffin-embedded tissue specimens and clinical data collected from a retrospective chart review.	Paraffin	107-115	fatty acid synthase	Homo sapiens	9-13
23326344-4	2013	PATIENTS AND METHODS: Quantitative real-time polymerase chain reaction (qPCR) was performed to examine BRCA1 mRNA expressions in paraffin-embedded specimens from 144 patients with advanced or metastatic esophageal squamous cell carcinoma who received cisplatin- or docetaxel-based first-line treatments.	Paraffin	129-137	BRCA1 DNA repair associated	Homo sapiens	103-108
23327700-2	2012	METHODS: The expression of CAI and CAII protein in 57 pairs of paraffin-embedded PDAC specimens and adjacent non-cancerous pancreatic tissues were detected by immunohistochemistry.	Paraffin	63-71	carbonic anhydrase 1	Homo sapiens	27-30
23327700-2	2012	METHODS: The expression of CAI and CAII protein in 57 pairs of paraffin-embedded PDAC specimens and adjacent non-cancerous pancreatic tissues were detected by immunohistochemistry.	Paraffin	63-71	carbonic anhydrase 2	Homo sapiens	35-39
22972152-3	2012	We investigated immunohistochemical expression of NDRG1 protein in 412 tissue microarray cores of tumor samples from 103 patients with oral and oropharyngeal squamous cell carcinomas and in 110 paraffin-embedded surgical margin sections.	Paraffin	194-202	N-myc downstream regulated 1	Homo sapiens	50-55
22887004-5	2012	An immunohistochemical localization of CART was performed on paraffin GI tract sections from all the study animals.	Paraffin	61-69	CART prepropeptide	Rattus norvegicus	39-43
22993408-9	2012	These MAbs are the first reported anti-NS1 MAbs that can be used for WNV-specific IHC using formalin-fixed, paraffin-embedded sections.	Paraffin	108-116	influenza virus NS1A binding protein	Homo sapiens	39-42
22986464-7	2012	Using paraffin-embedded tumors from patients with newly diagnosed GBM (n = 59), tumor MGMT promoter hypermethylation (MGMT gene silencing) was significantly associated with increased immunohistochemical expression of the proinvasive matricellular protein secreted protein acidic and rich in cysteine (SPARC; P = 0.039, chi(2) test).	Paraffin	6-14	O-6-methylguanine-DNA methyltransferase	Homo sapiens	86-90
22986464-7	2012	Using paraffin-embedded tumors from patients with newly diagnosed GBM (n = 59), tumor MGMT promoter hypermethylation (MGMT gene silencing) was significantly associated with increased immunohistochemical expression of the proinvasive matricellular protein secreted protein acidic and rich in cysteine (SPARC; P = 0.039, chi(2) test).	Paraffin	6-14	O-6-methylguanine-DNA methyltransferase	Homo sapiens	118-122
22732508-0	2012	Application of pyrosequencing technique for improved detection of K-Ras mutation in formalin-fixed and paraffin-embedded prostate carcinoma tissues in Chinese patients.	Paraffin	103-111	KRAS proto-oncogene, GTPase	Homo sapiens	66-71
22732508-1	2012	BACKGROUND: The purpose of this study was to comparatively evaluate the efficacy of pyrosequencing (PS) and Sanger sequencing (SS) methods for detecting K-Ras codon 12 and 13 mutations in formalin-fixed paraffin-embedded (FFPE) prostate cancer (PCa) samples from Chinese patients.	Paraffin	203-211	KRAS proto-oncogene, GTPase	Homo sapiens	153-158
21990036-0	2012	Quantitative determination of insulin-like growth factor 1 receptor mRNA in formalin-fixed paraffin-embedded tissues of invasive breast cancer.	Paraffin	91-99	insulin like growth factor 1 receptor	Homo sapiens	30-67
22810971-5	2012	METHODS: CDH17 and CDX2 expressions in 182 paraffin-embedded EOC specimens were detected by immunohistochemical staining.	Paraffin	43-51	caudal type homeobox 2	Homo sapiens	19-23
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Paraffin	97-105	TNF receptor superfamily member 8	Homo sapiens	149-156
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Paraffin	97-105	tropomodulin 1	Homo sapiens	169-174
22740451-5	2012	Application of quantitative RT-PCR in independent datasets from cryopreserved and formalin-fixed paraffin-embedded samples validated a 3-gene model (TNFRSF8, BATF3, and TMOD1) able to successfully separate ALK(-) ALCL from peripheral T-cell lymphoma not otherwise specified, with overall accuracy near 97%.	Paraffin	97-105	ALK receptor tyrosine kinase	Homo sapiens	206-209
23157907-2	2012	METHODS: The expression of CAII protein in 33 paired paraffin embedded IDC specimens of the pancreas and paired adjacent non-cancerous pancreatic tissues was detected by immunohistochemistry.	Paraffin	53-61	carbonic anhydrase 2	Homo sapiens	27-31
21834786-3	2012	Proliferating cell nuclear antigen (PCNA) was detected using immunohistochemical method on paraffin sections in the epidermis of dorsal skin and footpad in these animals obtained from the National Institute on Aging.	Paraffin	91-99	proliferating cell nuclear antigen	Rattus norvegicus	0-34
21834786-3	2012	Proliferating cell nuclear antigen (PCNA) was detected using immunohistochemical method on paraffin sections in the epidermis of dorsal skin and footpad in these animals obtained from the National Institute on Aging.	Paraffin	91-99	proliferating cell nuclear antigen	Rattus norvegicus	36-40
22006578-0	2012	TS and DPD mRNA levels on formalin-fixed paraffin-embedded specimens as predictors for distant recurrence of rectal cancer treated with preoperative chemoradiotherapy.	Paraffin	41-49	dihydropyrimidine dehydrogenase	Homo sapiens	7-10
22537306-3	2012	METHODS: MTA1 expression was assessed using immunohistochemistry in paraffin-embedded tumor specimens from 208 untreated NPC patients.	Paraffin	68-76	metastasis associated 1	Homo sapiens	9-13
22433565-4	2012	Immunohistochemical analysis of PRAF3 expression was carried out in paraffin-embedded sections of ESCC and correlated with clinical features.	Paraffin	68-76	ADP ribosylation factor like GTPase 6 interacting protein 5	Homo sapiens	32-37
23098460-3	2012	TMEM166 protein expression was analysed in paraffin-embedded tissue samples from the same cases by immunohistochemistry.	Paraffin	43-51	eva-1 homolog A, regulator of programmed cell death	Homo sapiens	0-7
23167412-3	2012	METHODS: Immunohistochemistry for FoxM1 expression was performed on paraffin-embedded tumor tissues from 165 NSCLC patients.	Paraffin	68-76	forkhead box M1	Homo sapiens	34-39
21922591-9	2012	Pyrosequencing proved a good method for assessing the degree of MGMT methylation in formalin-fixed paraffin-embedded glioma samples.	Paraffin	99-107	O-6-methylguanine-DNA methyltransferase	Homo sapiens	64-68
22745574-2	2012	METHODS: Expression of Gli-1 was detected by immunohistochemistry in paraffin-embedded specimens of 96 cases of colon cancer.	Paraffin	69-77	GLI family zinc finger 1	Homo sapiens	23-28
22275824-3	2012	METHODS: LMP1-functionalized 4-mercaptobenzoic acid (4-MBA)-labeled Au/Ag core-shell bimetallic nanoparticles were prepared first and then applied for analyzing LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections obtained from 34 cancer patients and 20 healthy controls.	Paraffin	184-192	PDZ and LIM domain 7	Homo sapiens	9-13
22275824-5	2012	RESULTS: Data from SERS spectra and images show that this new SERS-based immunoassay detected LMP1 in formalin-fixed paraffin-embedded nasopharyngeal tissue sections with high sensitivity and specificity.	Paraffin	117-125	PDZ and LIM domain 7	Homo sapiens	94-98
21792731-1	2012	We have determined O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status by methylation-specific polymerase chain reaction (MSP) in 22 paraffin-embedded specimens of glioblastoma multiforme.	Paraffin	157-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	19-59
21792731-1	2012	We have determined O(6)-methylguanine-DNA-methyltransferase (MGMT) promoter methylation status by methylation-specific polymerase chain reaction (MSP) in 22 paraffin-embedded specimens of glioblastoma multiforme.	Paraffin	157-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	61-65
21699410-9	2011	KRAS mutation screening on formalin-fixed, paraffin-embedded DNA is very efficient with real-time PCR methods in comparison to direct sequencing.	Paraffin	43-51	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
21887466-3	2011	Expression of DNMT1, DNMT3A and DNMT3B in paraffin sections from 54 gastric cancer patients were examined using immunohistochemistry, and their associations with the corresponding clinicopathological parameters were analyzed using the Chi-square test.	Paraffin	42-50	DNA methyltransferase 1	Homo sapiens	14-19
21640373-2	2011	METHODS: We designed and optimized a matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) genotyping assay to detect FOXL2 C402G mutation in DNA isolated from formalin-fixed paraffin-embedded tissue samples.	Paraffin	213-221	forkhead box L2	Homo sapiens	156-161
21406308-0	2011	Coamplification at lower denaturation temperature polymerase chain reaction enables selective identification of K-Ras mutations in formalin-fixed, paraffin-embedded tumor tissues without tumor-cell enrichment.	Paraffin	147-155	KRAS proto-oncogene, GTPase	Homo sapiens	112-117
21406308-9	2011	The technique is a good strategy to detect K-Ras mutations selectively in formalin-fixed, paraffin-embedded tissues without tumor-cell enrichment.	Paraffin	90-98	KRAS proto-oncogene, GTPase	Homo sapiens	43-48
22031799-3	2011	METHODS: Immunohistochemistry was used to detect GPER in paraffin-embedded tissues of primary breast cancers from 423 patients and GPER expression was correlated with clinicopathological factors.	Paraffin	57-65	G protein-coupled estrogen receptor 1	Homo sapiens	49-53
21640634-9	2011	IGF-1R expression was studied by immunohistochemistry in paraffin-embedded tumour tissue.	Paraffin	57-65	insulin like growth factor 1 receptor	Homo sapiens	0-6
21251039-3	2011	METHODS: A commercially available antibody to CK15 was used on formalin-fixed, paraffin-embedded tissue from clinically and histologically "normal" scalps, clinically diseased scalps from patients with CCCA and clinically "normal" scalps from patients with CCCA.	Paraffin	79-87	keratin 15	Homo sapiens	46-50
21422430-13	2011	CONCLUSION: Intratumoral CD8+ lymphocyte infiltration can be readily assessed on paraffin-embedded tissue, is independently associated with improved MCC-specific survival, and therefore, may provide prognostic information that enhances established MCC staging protocols.	Paraffin	81-89	CD8a molecule	Homo sapiens	25-28
21070201-3	2011	OBJECTIVES: To assess the immunoreactivity of Plk1 in cutaneous T-cell lymphoma (CTCL) as a potential therapeutic target, to differentiate Plk1 levels among lesion types and to compare the detection level of Plk1 in fresh frozen (f) vs. paraffin-embedded (p) tissue.	Paraffin	237-245	polo like kinase 1	Homo sapiens	46-50
21208810-4	2011	In addition, the activation status of VEGFR2/KDR receptors was investigated in formalin-fixed paraffin embedded tissues and related to VEGF.	Paraffin	94-102	kinase insert domain receptor	Homo sapiens	38-44
21208810-4	2011	In addition, the activation status of VEGFR2/KDR receptors was investigated in formalin-fixed paraffin embedded tissues and related to VEGF.	Paraffin	94-102	kinase insert domain receptor	Homo sapiens	45-48
20429013-5	2011	We found that 93 of 136 (68.4%) paraffin-embedded archival RCC biopsies showed positive expression of Tiam1.	Paraffin	32-40	TIAM Rac1 associated GEF 1	Homo sapiens	102-107
21258089-0	2011	KRAS mutation analysis in genomic DNA isolated from formalin-fixed paraffin-embedded ovarian tissue: evaluation of a strip-based reverse-hybridisation assay.	Paraffin	67-75	KRAS proto-oncogene, GTPase	Homo sapiens	0-4
21111450-0	2011	Identification of t(17;22)(q22;q13) (COL1A1/PDGFB) in dermatofibrosarcoma protuberans by fluorescence in situ hybridization in paraffin-embedded tissue microarrays.	Paraffin	127-135	collagen type I alpha 1 chain	Homo sapiens	37-43
21111450-0	2011	Identification of t(17;22)(q22;q13) (COL1A1/PDGFB) in dermatofibrosarcoma protuberans by fluorescence in situ hybridization in paraffin-embedded tissue microarrays.	Paraffin	127-135	platelet derived growth factor subunit B	Homo sapiens	44-49
22553708-2	2011	METHODS: Immunohistochemical technique was used to detect the expression of MMP-2 and MMP-9 in 41 cases of paraffin embedded Rb samples.	Paraffin	107-115	matrix metallopeptidase 9	Homo sapiens	86-91
21734413-3	2011	METHODS: CXCR4 expression was evaluated by immunohistochemical staining in paraffin-embedded tissue sections of primary breast cancers from 20 patients with bone metastases (BM), 10 with visceral metastases (VM) and 10 with no evidence of disease (NED) at a median follow-up of 10.5 years (range 10.1-11.8).	Paraffin	75-83	C-X-C motif chemokine receptor 4	Homo sapiens	9-14
21107115-9	2010	Antibody staining analysis of paraffin-embedded archival tissue breast tumors and flow cytometry of breast cancer cell lines demonstrated B7-H3 protein expression.	Paraffin	30-38	CD276 antigen	Mus musculus	138-143
20697266-0	2010	Characterization of a new monoclonal antibody against PAX5/BASP in 1525 paraffin-embedded human and animal tissue samples.	Paraffin	72-80	paired box 5	Homo sapiens	54-58
20560954-4	2010	Immunohistochemistry was applied to identify HLA-G expression in formalin-fixed paraffin-embedded cutaneous skin biopsies.	Paraffin	80-88	major histocompatibility complex, class I, G	Homo sapiens	45-50
20812987-5	2010	In 126 paraffin-embedded CRC samples, three differentially expressed proteins, identified as LASP-1, S100A9 and RhoGDI by proteomic analysis, were detected by immunohistochemical staining to determine the clinicopathological characteristics of these proteins in CRC.	Paraffin	7-15	LIM and SH3 protein 1	Homo sapiens	93-99
20811686-5	2010	Methylation-specific PCR (MSP) was performed to study inactivation of SFRP-1, SFRP-2, SFRP-4, SFRP-5, WIF-1, DKK-3 genes in 37 cases of paraffin embedded oral cancer.	Paraffin	136-144	WNT inhibitory factor 1	Homo sapiens	102-107
20022135-3	2010	The expression of IL-17 was measured by immunohistochemistry in 52 paraffin-embedded tissues with non-small cell lung cancer.	Paraffin	67-75	interleukin 17A	Homo sapiens	18-23
20574164-3	2010	Dynamin 2 expression was evaluated at protein level in thirty seven paraffin-embedded, formalin-fixed tissues including four normal cervix tissues and compared with pathologic risk factors for recurrence after surgery in thirty three patients with squamous cell carcinoma of the cervix.	Paraffin	68-76	dynamin 2	Homo sapiens	0-9
20557864-2	2010	METHODS: Using the fluorescence property of QDs and indirect immunofluorescence methods to detect the IgA and complement C3 in formalin-fixed paraffin-embedded (FFPE) tissues of IgAN.	Paraffin	142-150	complement C3	Homo sapiens	110-123
20381118-6	2010	Histologic examination revealed a massive deposition of Congo red-positive amyloid identified as amyloid protein transthyretin by both immunohistochemistry and mass spectrometry using formalin-fixed, paraffin-embedded tissues.	Paraffin	200-208	transthyretin	Homo sapiens	113-126
20081804-2	2010	In this study, we evaluated sphingosine-1-phosphate receptor 1"s suitability as a diagnostic marker for malignant lymphoma by immunostaining formalin-fixed paraffin-embedded sections using a well-defined commercial anti-sphingosine-1-phosphate receptor 1 antibody.	Paraffin	156-164	sphingosine-1-phosphate receptor 1	Homo sapiens	28-62
19473177-7	2010	RESULTS: Immunohistochemical analyses and double immunofluorescent staining of sectioned paraffin-embedded pituitary tissues revealed that CXCR4 is highly expressed in GH-producing pituitary adenomas and NFPAs.	Paraffin	89-97	C-X-C motif chemokine receptor 4	Homo sapiens	139-144
21092257-3	2010	The methylation status of CST6 gene encoding cystatin M was evaluated using methylation-specific polymerase chain reaction (PCR) in formalin-fixed paraffin-embedded tissues from 292 participants and using pyrosequencing in fresh-frozen tumor and matched normal tissues from 51 IBC patients.	Paraffin	147-155	cystatin E/M	Homo sapiens	26-30
21092257-3	2010	The methylation status of CST6 gene encoding cystatin M was evaluated using methylation-specific polymerase chain reaction (PCR) in formalin-fixed paraffin-embedded tissues from 292 participants and using pyrosequencing in fresh-frozen tumor and matched normal tissues from 51 IBC patients.	Paraffin	147-155	cystatin E/M	Homo sapiens	45-55
21197450-3	2010	We examined KRAS mutations in exon 2 codons 12 and 13 with DNA sequencing and SNaPshot analysis in 100 formalin-fixed paraffin-embedded tumor tissue samples of pancreatic carcinoma, colorectal carcinoma, and nonsmall cell lung cancer specimens of the primary tumor or metastases.	Paraffin	118-126	KRAS proto-oncogene, GTPase	Homo sapiens	12-16
20881409-1	2010	OBJECTIVE: Our aims were to measure the level of expression of Abelson (ABL1), beta-glucuronidase (GUS) and glucose-6-phosphate dehydrogenase (G6PD) genes in exfoliated urine cells from healthy and transrectal ultrasound biopsy patients with elevated prostate-specific antigen levels and/or abnormal digital rectal examinations or urinary symptoms indicative of prostate problems, as well as in archived formalin-fixed paraffin-embedded prostate materials.	Paraffin	419-427	glucose-6-phosphate dehydrogenase	Homo sapiens	143-147
19960330-5	2010	Terminal transferase-mediated UTP nick end-labeling (TUNEL) has been used successfully for detection of DNA degradation in paraffin-embedded tissue sections and can be combined with immunohistochemistry if desired to allow more precise identification of apoptotic cells.	Paraffin	123-131	DNA nucleotidylexotransferase	Homo sapiens	0-20
20037380-3	2009	The expression of DPD mRNA in cancer cells was quantified by reverse-transcriptase polymerase chain reaction (RT-PCR) using cancer cells obtained by micro-dissection of paraffin-embedded specimens (Danenberg tumor profiling method).	Paraffin	169-177	dihydropyrimidine dehydrogenase	Homo sapiens	18-21
19797612-0	2009	Sensitive detection of KRAS mutations in archived formalin-fixed paraffin-embedded tissue using mutant-enriched PCR and reverse-hybridization.	Paraffin	65-73	KRAS proto-oncogene, GTPase	Homo sapiens	23-27
19797612-2	2009	We report here a novel reverse-hybridization (RH) assay to screen for KRAS mutations in formalin-fixed paraffin-embedded colorectal tissue samples.	Paraffin	103-111	KRAS proto-oncogene, GTPase	Homo sapiens	70-74
19464247-0	2009	Pyrosequencing method to detect KRAS mutation in formalin-fixed and paraffin-embedded tumor tissues.	Paraffin	68-76	KRAS proto-oncogene, GTPase	Homo sapiens	32-36
19464247-2	2009	We have designed a pyrosequencing assay based on nested polymerase chain reaction (PCR) to characterize KRAS mutation status using formalin-fixed and paraffin-embedded tumor tissues.	Paraffin	150-158	KRAS proto-oncogene, GTPase	Homo sapiens	104-108
19464247-5	2009	Analysis of KRAS mutation using nested PCR and pyrosequencing is a simple, robust, fast, and sensitive method that can be used with formalin-fixed and paraffin-embedded tissues.	Paraffin	151-159	KRAS proto-oncogene, GTPase	Homo sapiens	12-16
19374895-3	2009	The prognostic significance of RASSF1A methylation was validated in 93 formalin fixed paraffin-embedded (FFPE) tissues obtained from patients with operable breast cancer.	Paraffin	86-94	Ras association domain family member 1	Homo sapiens	31-38
19513552-7	2009	HER2 protein levels directly correlated with FoxM1 expression in both breast carcinoma cell lines and paraffin-embedded breast cancer patient samples.	Paraffin	102-110	forkhead box M1	Homo sapiens	45-50
19329348-4	2009	Histopathological examination and immunostaining of MMP-3 were conducted using paraffin sections.	Paraffin	79-87	matrix metallopeptidase 3	Rattus norvegicus	52-57
19576004-8	2009	The protein SH-3BP-2, the calcitonin receptor and the tartrate-resistant acid phosphatase were detected in the cytoplasm of all multinucleated giant cells and parts of monokaryon matrix cells in 8 paraffin-imbedded samples.	Paraffin	197-205	SH3 domain binding protein 2	Homo sapiens	12-20
19521280-5	2009	Paraffin immunohistochemistry showed finely granular cytoplasmic ALK1 expression, positive CD138, IgA, p63 (VS38), focal positive epithelial membrane antigen and CD4, and lambda light chain restriction whereas negative CD20 and CD30 staining.	Paraffin	0-8	TNF receptor superfamily member 8	Homo sapiens	228-232
19005676-2	2009	S1P(1) of vascular and lymphatic endothelial cells can be detected by immunostaining of paraffin-embedded sections using a rabbit anti-S1P(1) antibody.	Paraffin	88-96	sphingosine-1-phosphate receptor 1	Homo sapiens	0-6
19011668-7	2008	Cell growth was quantified by using proliferating cell nuclear antigen (PCNA) in sections of paraffin-embedded vessels.	Paraffin	93-101	proliferating cell nuclear antigen	Rattus norvegicus	72-76
19130735-0	2008	Reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded neurosurgical biopsy specimens.	Paraffin	157-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	56-99
19130735-0	2008	Reliability and reproducibility of PCR-based testing of O6-methylguanine-DNA methyltransferase gene (MGMT) promoter methylation status in formalin-fixed and paraffin-embedded neurosurgical biopsy specimens.	Paraffin	157-165	O-6-methylguanine-DNA methyltransferase	Homo sapiens	101-105
18774496-3	2008	We used immunohistochemistry to examine the distribution and expression pattern of MCM2 on formalin-fixed paraffin-embedded tissue sections of benign (n = 30) and malignant breast tissue (n = 70) (IDC 56, DCIS 4, ILC 2, nonductal 4, mixed type 4).	Paraffin	106-114	minichromosome maintenance complex component 2	Homo sapiens	83-87
18242762-7	2008	In situ PCR of a paraffin block section showed that the carcinoma with expression of the variant 1 actually contained an EML4-ALK fusion gene.	Paraffin	17-25	EMAP like 4	Homo sapiens	121-125
18242762-7	2008	In situ PCR of a paraffin block section showed that the carcinoma with expression of the variant 1 actually contained an EML4-ALK fusion gene.	Paraffin	17-25	ALK receptor tyrosine kinase	Homo sapiens	126-129
18589866-5	2008	Here we describe the use of an antibody to human Pax5 in diagnostic pathology with formalin-fixed, paraffin-embedded mouse tissue.	Paraffin	99-107	paired box 5	Homo sapiens	49-53
18379900-8	2008	RT-PCR using RNA extracted and purified from formalin-fixed paraffin-embedded pituitary adenoma specimens revealed MSX1 mRNA expressed in GH- and TSH-producing adenomas.	Paraffin	60-68	msh homeobox 1	Homo sapiens	115-119
18357369-4	2008	We further determined the BIGH3 protein levels in 52 cc-RCC paraffin-embedded tissue samples by immunohistochemistry.	Paraffin	60-68	transforming growth factor beta induced	Homo sapiens	26-31
18347934-4	2008	Expression of MMP-9 was determined on paraffin embedded biopsy sections by immunohistochemistry in 31 CRC patients (from cancer tissue and corresponding normal mucosa) and in 30 patients with adenoma (nine adenomas with high grade of dysplasia).	Paraffin	38-46	matrix metallopeptidase 9	Homo sapiens	14-19
18223326-4	2008	Second, an immunohistochemical analysis was performed using a commercially available anti-HSD3B1 monoclonal antibody on paraffin sections.	Paraffin	120-128	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Homo sapiens	90-96
18158131-4	2008	In this review, two different methods for the in situ detection of miR in paraffin embedded, formalin fixed tissues are described.	Paraffin	74-82	membrane associated ring-CH-type finger 8	Homo sapiens	67-70
18000219-3	2007	METHODS: We used a breast cancer disease-specific microarray to identify transcripts that were differentially expressed between paraffin-embedded samples of 17 BRCA1-mutant and 14 sporadic breast tumors.	Paraffin	128-136	BRCA1 DNA repair associated	Homo sapiens	160-165
17725669-5	2007	METHODS: We analysed paraffin tissue sections from 27 patients with LyP, 10 with C-ALCL, eight with T-MF and two with cutaneous HL by immunohistochemistry with antibodies against c-JUN, JUNB, JUND, c-FOS and RAF-1.	Paraffin	21-29	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	179-184
17914564-7	2007	Paraffin-embedded tissues from 11 cases were used to confirm the expression of matrix metalloproteinase 9 (MMP-9) and tubulin-alpha proteins in the non-tumor and PSH tissues via IHC.	Paraffin	0-8	matrix metallopeptidase 9	Homo sapiens	79-105
17914564-7	2007	Paraffin-embedded tissues from 11 cases were used to confirm the expression of matrix metalloproteinase 9 (MMP-9) and tubulin-alpha proteins in the non-tumor and PSH tissues via IHC.	Paraffin	0-8	matrix metallopeptidase 9	Homo sapiens	107-112
17895758-5	2007	In 48 cases, the amplification status of MDM2 and CDK4 could be evaluated with quantitative polymerase chain reaction on paraffin-embedded tissues extracted DNAs.	Paraffin	121-129	MDM2 proto-oncogene	Homo sapiens	41-45
17654496-7	2007	Anti- KLK12 antibody was used for immunostaining of paraffin-embedded sections of human prostate tissue.	Paraffin	52-60	kallikrein related peptidase 12	Homo sapiens	6-11
17555500-0	2007	Identification of MEN1 and HRPT2 somatic mutations in paraffin-embedded (sporadic) parathyroid carcinomas.	Paraffin	54-62	cell division cycle 73	Homo sapiens	27-32
17490736-8	2007	IGF-1R expression was studied by immunohistochemistry in paraffin-embedded tumor tissue.	Paraffin	57-65	insulin like growth factor 1 receptor	Homo sapiens	0-6
17466383-8	2007	A polyclonal antibody against an extracellular fragment of the CD34 polypeptide was characterized using Western blots, cytocentrifuge preparates, and paraffin sections.	Paraffin	150-158	CD34 molecule	Bos taurus	63-67
17723190-3	2007	The serial sections of those paraffin embedded samples were applied respectively for (1) hematoxylin and eosin (HE) staining, (2) WS staining, (3) streptomyces avidin-peroxidase (SP) immunohistochemical staining for mouse anti-human CD68 monoclonal antibody, (4) observing under transmission electron microscope (TEM), (5) X-ray spectrum chemical element analysis(X-RSA).	Paraffin	29-37	CD68 molecule	Homo sapiens	233-237
17260000-0	2007	A simplified laboratory validated assay for MGMT promoter hypermethylation analysis of glioma specimens from formalin-fixed paraffin-embedded tissue.	Paraffin	124-132	O-6-methylguanine-DNA methyltransferase	Homo sapiens	44-48
17260000-5	2007	The objective of this study was to develop a reliable, clinically validated assay for detection of epigenetic silencing of the MGMT gene using formalin-fixed, paraffin-embedded brain tumor resections and methylation-specific PCR.	Paraffin	159-167	O-6-methylguanine-DNA methyltransferase	Homo sapiens	127-131
17170388-4	2007	METHODS: RAGE and major ligands (N-epsilon-carboxy-methyl-lysine [CML], S100A12, and S100B) expression was investigated by immunostaining of 99 paraffin-embedded biopsies of sarcoid tissues, and expression patterns were determined.	Paraffin	144-152	advanced glycosylation end-product specific receptor	Homo sapiens	9-13
17195907-2	2007	METHODS: We retrospectively examined the immunohistochemical expression of RANKL in formalin-fixed, paraffin-embedded resected specimens obtained from 96 patients with HCC with (n = 16) and without (n = 80) bone metastases.	Paraffin	100-108	TNF superfamily member 11	Homo sapiens	75-80
16933138-3	2007	CASE REPORT: We investigated the expression of E-cadherin and N-cadherin in paraffin-embedded sequential surgical specimens and autopsy specimens from a 4-year-old girl with recurrent ependymoma, subsequent to cerebrospinal fluid (CSF) dissemination.	Paraffin	76-84	cadherin 2	Homo sapiens	62-72
17164758-3	2007	Preliminary microarray comparisons on DCIS and invasive carcinoma samples dissected from formalin-fixed paraffin sections showed a consistent downregulation of two previously identified FHIT-related genes, caspase 1 and BRCA1 in lesions underexpressing FHIT.	Paraffin	104-112	BRCA1 DNA repair associated	Homo sapiens	220-225
16944270-3	2007	Archival paraffin tissue blocks of their tumors were retrieved for DNA-extraction to analyze the founder mutation, BRCA1 c.3171_3175dup (c.3171ins5), which is most common in this geographic area and four other common Scandinavian BRCA1 gene mutations and one BRCA2 mutation.	Paraffin	9-17	BRCA1 DNA repair associated	Homo sapiens	115-120
17419234-3	2007	METHODOLOGY: Expression of the VEGF-C and VEGF-D in human submucosal colorectal cancers was investigated in paraffin-embedded stepwise sections by means of immunohistochemistry, and the correlation between immunohistochemical expression pattern and clinicopathological features was also evaluated.	Paraffin	108-116	vascular endothelial growth factor D	Homo sapiens	42-48
17969435-5	2007	The results obtained show that the optimal demonstration of nNOS in paraffin sections requires immersion fixation in Carnoy solution or posfixation in this solution following a perfusion with 4% paraformaldehyde solution.	Paraffin	68-76	nitric oxide synthase 1	Rattus norvegicus	60-64
17149955-4	2006	EWS-FLI1 was detected by reverse transcriptase polymerase chain reaction on all 32 fresh FNAC samples and by fluorescence in situ hybridization on 16 paraffin blocks.	Paraffin	150-158	Fli-1 proto-oncogene, ETS transcription factor	Homo sapiens	4-8
17145843-4	2006	EXPERIMENTAL DESIGN: We evaluated 294 hematologic neoplasms for the presence of CD52 using standard immunohistochemical techniques on paraffin-embedded biopsy specimens fixed with formalin, B-Plus, Zenker"s acetic acid, or B5-formalin.	Paraffin	134-142	CD52 molecule	Homo sapiens	80-84
16998464-4	2006	We have examined the expression of the standard CD44 (CD44s) by immunohistochemical stains in the paraffin-embedded cervical neoplasm tissue of 17 cases of primary cervical neuroendocrine carcinoma, 28 cases of cervical adenocarcinoma, and 50 cases of cervical squamous cell carcinoma.	Paraffin	98-106	CD44 molecule (Indian blood group)	Homo sapiens	48-52
16998464-4	2006	We have examined the expression of the standard CD44 (CD44s) by immunohistochemical stains in the paraffin-embedded cervical neoplasm tissue of 17 cases of primary cervical neuroendocrine carcinoma, 28 cases of cervical adenocarcinoma, and 50 cases of cervical squamous cell carcinoma.	Paraffin	98-106	CD44 molecule (Indian blood group)	Homo sapiens	54-59
16556662-11	2006	CONCLUSIONS: Immunohistochemical staining for adipophilin and perilipin is a useful ancillary technique for the demonstration of lipid in SGC that may be applied to paraffin-wax sections.	Paraffin	165-177	perilipin 1	Homo sapiens	62-71
17327058-2	2006	METHODS: The expression of lymphatic vessel endothelium markers podoplanin, VEGFR-3 and vascular endothelium marker CD31 was detected in paraffin sections from 68 cases of NSCLC and 8 cases of pulmonary inflammatory myofibroblastic tumor (PIMT) by immunohistochemistry (SP).	Paraffin	137-145	fms related receptor tyrosine kinase 4	Homo sapiens	76-83
16938666-6	2006	Pax-5, BOB.1, and CD79a antigens are the most reliable B-lineage markers for paraffin immunophenotyping B-ALL/B-LBL.	Paraffin	77-85	paired box 5	Homo sapiens	0-5
16965426-6	2006	In addition, the presence of Tn-C protein was analysed in sections of paraffin-embedded tissues using immunohistochemistry.	Paraffin	70-78	tenascin C	Homo sapiens	29-33
16784742-3	2006	PERP protein levels were assessed by Western blot analysis of 22 fresh-frozen tumors and by immunohistochemical analysis of 16 paraffin-embedded tumor specimens.	Paraffin	127-135	p53 apoptosis effector related to PMP22	Homo sapiens	0-4
16938520-3	2006	The combined pattern analysis and detection of 70-kd zeta-associated protein (ZAP-70) expression in formalin-fixed, paraffin-embedded bone marrow trephines has not been investigated so far.	Paraffin	116-124	zeta chain of T cell receptor associated protein kinase 70	Homo sapiens	78-84
17134548-4	2006	The expression of TPX2 was studied by immunohistochemistry (using tissue microarray) on paraffin-embedded sections of pulmonary SCC and corresponding precancerous lesions from a group of 319 patients.	Paraffin	88-96	TPX2 microtubule nucleation factor	Homo sapiens	18-22
16923563-3	2006	The tissue CA125 expression in 22 patients with NHL was performed on paraffin section by immunohistochemical methods.	Paraffin	69-77	mucin 16, cell surface associated	Homo sapiens	11-16
17067458-2	2006	METHODS: The protein expression of DNMT1 and DNMT3b were examined by immunohistochemistry in paraffin-embedded tissues of ACC from 60 patients.	Paraffin	93-101	DNA methyltransferase 1	Homo sapiens	35-40
16395704-12	2006	In conclusion, our antibody was demonstrated to be useful in recognizing MASP-2 expression on paraffin embedded tissue sections.	Paraffin	94-102	MBL associated serine protease 2	Homo sapiens	73-79
16376424-2	2006	To investigate the expression of ICAM-1 by villous trophoblasts, its relationship with rupture of the trophoblastic barrier and influx of immune cells into the villi, we analysed 18 paraffin-embedded placentas with placentitis (5 by Toxoplasma gondii, 3 by Trypanosoma cruzi, 2 by Paracoccidioides brasiliensis and 8 of unknown aetiology - VUE) and 8 control placentas for detection of ICAM-1 by immunohistochemistry.	Paraffin	182-190	intercellular adhesion molecule 1	Homo sapiens	33-39
16869242-6	2006	METHODS: We evaluated the expression of Id2 protein using immunohistochemistry in formalin-fixed, paraffin-embedded specimens from a total of 71 cases of Ewing sarcoma.	Paraffin	98-106	inhibitor of DNA binding 2	Homo sapiens	40-43
16541450-3	2006	METHODS: The authors examined the distribution of CDX2 expression in carcinoma specimens using paraffin-embedded tissues from various organs from 549 cancer patients.	Paraffin	95-103	caudal type homeobox 2	Homo sapiens	50-54
16630118-3	2006	In the present study, expression of PLK1 was investigated in paraffin tissue of 135 cases of gastric adenocarcinoma and in 46 corresponding lymph node metastases by immunohistochemistry.	Paraffin	61-69	polo like kinase 1	Homo sapiens	36-40
16609025-10	2006	CONCLUSIONS: CCNE expression assessment is easy on paraffin-embedded tissue.	Paraffin	51-59	cyclin E1	Homo sapiens	13-17
16618609-3	2006	METHODS: Pan mycobacterium primers of the 65-kDa heat shock protein gene (Hsp65) were used in a polymerase chain reaction (PCR) to examine 12 surgically-resected, formalin-fixed, paraffin-embedded specimens from 11 patients with Crohn"s disease.	Paraffin	179-187	heat shock protein family D (Hsp60) member 1	Homo sapiens	74-79
16344946-6	2006	Immunohistochemistry of paraffin-embedded sections of E12 CAM revealed anx-1 in CC cells and VC cells.	Paraffin	24-32	annexin A1	Gallus gallus	71-76
16520839-4	2006	METHODS: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections.	Paraffin	170-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
16520839-4	2006	METHODS: We immunohistochemically examined c-Jun protein activation in human oral squamous cell carcinomas (SCC) using an anti-phosphospecific c-Jun (pc-Jun) antibody on paraffin-embedded sections.	Paraffin	170-178	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	143-148
16776850-4	2006	METHODS: MMP-2, MMP-14 and TIMP-2 expression has been evaluated by 35S mRNA in situ hybridization on paraffin material of 539 breast cancers without distant metastasis at diagnosis and with a median follow-up of 9.2 years.	Paraffin	101-109	TIMP metallopeptidase inhibitor 2	Homo sapiens	27-33
16724247-2	2006	Documentation of familial BRCA mutations from paraffin-derived DNA of deceased patients has been limited due to reports of technical complications leading to lack of reproducibility of BRCA testing of archival material.	Paraffin	46-54	BRCA1 DNA repair associated	Homo sapiens	26-30
16930013-7	2006	In this chapter, we present methodology for detection of genetic inactivation of TSC1 and TSC2 in paraffin-embedded archival tissues.	Paraffin	98-106	TSC complex subunit 2	Homo sapiens	90-94
16362798-6	2005	We investigated the immunohistochemical expression of CD30 antigen in 15 paraffin-embedded tissue samples representing epidermis and epidermal buds from foetuses after spontaneous abortion in the 8th, 10th and 12th weeks of gestation, respectively, using the monoclonal antibody NCL-CD30.	Paraffin	73-81	TNF receptor superfamily member 8	Homo sapiens	54-58
15956029-4	2005	When applied to the study of the levels of MRP2, a member of the human multidrug resistance-associated protein family, in samples obtained from formalin-fixed, paraffin-embedded liver biopsies, it allowed the reliable evaluation of the protein content of the tissue.	Paraffin	160-168	ATP binding cassette subfamily C member 2	Homo sapiens	43-47
16328668-2	2005	We evaluated livin expression in paraffin-embedded tumor tissue from 68 patients with neuroblastoma (NB) and 7 NB cell lines by immunoperoxidase using an anti-livin monoclonal antibody.	Paraffin	33-41	baculoviral IAP repeat containing 7	Homo sapiens	13-18
16457151-4	2005	METHODS: The protein expression of p185(HER2) and PTEN was examined by immunohistochemical stain in paraffin-embedded tissues of 94 (M:F, 52:42) gastric adenocarcinoma patients by using monoclonal antibody, and the results were related to clinicopathological variables and survival.	Paraffin	100-108	eukaryotic translation initiation factor 3 subunit A	Homo sapiens	35-39
16137526-2	2005	MATERIAL AND METHODS: MIB-1 monoclonal antibody was used for comparative assessment of proliferative activity of middle ear cholesteatoma, external auditory canal skin, and retroauricular skin samples on formalin-fixed paraffin-embedded tissue sections.	Paraffin	219-227	MIB E3 ubiquitin protein ligase 1	Homo sapiens	22-27
16144916-2	2005	EXPERIMENTAL DESIGN: The expression of Cdx2 and Hep were studied using immunohistochemistry of paraffin-embedded tumor specimens from 109 patients who underwent D2 resection for gastric adenocarcinoma from 1995 to 1998.	Paraffin	95-103	caudal type homeobox 2	Homo sapiens	39-43
15932552-2	2005	PATIENTS AND METHODS: As a method we used PCR-RFLP technique, to examine ki-ras codons 12 and 13 mutations in 450 paraffin embedded tissues, consisting of 141 normal mucosas, 165 adenomas and 144 sporadic colorectal cancers taken from 141 patients.	Paraffin	114-122	KRAS proto-oncogene, GTPase	Homo sapiens	73-79
15944936-15	2005	This study successfully analyzed CX3CR1 SNP and transcript expression in microdissected cells from archived paraffin fixed slides.	Paraffin	108-116	C-X3-C motif chemokine receptor 1	Homo sapiens	33-39
15832085-2	2005	We tested the expression of the CD163 protein in 1,105 human malignancies and normal tissues using tissue microarrays and conventional paraffin-embedded tissue sections.	Paraffin	135-143	CD163 molecule	Homo sapiens	32-37
15832095-6	2005	Based on our immunohistochemistry results using a monoclonal anti-PAX5 antibody with paraffin-embedded tissue sections, we report herein that PAX-5 was detected in 29 of 31 (93.5%) of Merkel cell carcinoma and 22 of 30 (73.3%) of small cell carcinoma, but in none of 17 cases of carcinoid tumor.	Paraffin	85-93	paired box 5	Homo sapiens	66-70
15832095-6	2005	Based on our immunohistochemistry results using a monoclonal anti-PAX5 antibody with paraffin-embedded tissue sections, we report herein that PAX-5 was detected in 29 of 31 (93.5%) of Merkel cell carcinoma and 22 of 30 (73.3%) of small cell carcinoma, but in none of 17 cases of carcinoid tumor.	Paraffin	85-93	paired box 5	Homo sapiens	142-147
15867228-3	2005	EXPERIMENTAL DESIGN: Immunohistochemical staining for CD44 isoforms was done on archival paraffin tissue sections of invasive breast carcinoma from a cohort of lymph node-negative patients who received no adjuvant tamoxifen or chemotherapy and who had a mean clinical follow-up period of 15 years.	Paraffin	89-97	CD44 molecule (Indian blood group)	Homo sapiens	54-58
16091175-7	2005	Immunohistochemical staining demonstrated that G3BP was over-expressed in formalin-fixed and paraffin-embedded tissues of some human tumors, such as lung cancer, colon cancer, gastric cancer and breast cancer.	Paraffin	93-101	G3BP stress granule assembly factor 1	Homo sapiens	47-51
15735157-6	2005	RESULTS: The staining protocol was practical to perform and the results were morphologically and quantitatively indistinguishable from those after immunostaining with MIB-1, an antibody recognising Ki-67 in paraffin wax embedded tissue.	Paraffin	207-219	MIB E3 ubiquitin protein ligase 1	Homo sapiens	167-172
15735157-7	2005	A comparison of Ultrarapid-Ki67 and MIB-1 immunostaining of paraffin wax sections showed almost identical quantitative correlation in astrocytic gliomas (r = 0.916; p&lt;0.001).	Paraffin	60-72	MIB E3 ubiquitin protein ligase 1	Homo sapiens	36-41
15723650-5	2005	Also, the beta-catenin gene mutations in paraffin-embedded colonic adenocarcinomas were analyzed by the single strand conformation polymorphism method, restriction enzyme fragment length polymorphism and direct sequencing.	Paraffin	41-49	catenin (cadherin associated protein), beta 1	Mus musculus	10-22
15606671-3	2005	METHODS: Gli1 transcript levels were measured by real-time quantitative reverse transcriptase polymerase chain reaction (RT-PCR) using RNA extracted from formalin-fixed, paraffin-embedded tissues of 68 cases of various skin tumors.	Paraffin	170-178	GLI family zinc finger 1	Homo sapiens	9-13
16040406-3	2005	We studied the breakpoints of the COL1A1 gene using formalin-fixed, paraffin-embedded tumour specimens from five patients with dermatofibrosarcoma protuberans (three reconfirmations and two new cases).	Paraffin	68-76	collagen type I alpha 1 chain	Homo sapiens	34-40
16786769-4	2005	Analysed were prognostic factors as follows: age, stage, tumor grade, depth of myometrial invasion, hormone receptors, expression of the tumor suppressor gene p53, Her 2/neu and MIB-1 (ki-67 paraffin).	Paraffin	191-199	MIB E3 ubiquitin protein ligase 1	Homo sapiens	178-183
15976947-6	2005	Immunohistochemical detection of MMP-9 expression was done using a wet autoclave antigen retrieval method on sections from formalin-fixed and paraffin-embedded lung tissue.	Paraffin	142-150	matrix metallopeptidase 9	Homo sapiens	33-38
15805074-4	2005	In the present study we demonstrated that in rat formalin-fixed, paraffin-embedded ovary sections follicles of all degrees of maturity can be visualized by the use of antibody directed against proliferating cell nuclear antigen (PCNA).	Paraffin	65-73	proliferating cell nuclear antigen	Rattus norvegicus	193-227
15805074-4	2005	In the present study we demonstrated that in rat formalin-fixed, paraffin-embedded ovary sections follicles of all degrees of maturity can be visualized by the use of antibody directed against proliferating cell nuclear antigen (PCNA).	Paraffin	65-73	proliferating cell nuclear antigen	Rattus norvegicus	229-233
15623623-2	2004	EXPERIMENTAL DESIGN: Immunohistochemical staining for IGF-1R was done on formalin-fixed, paraffin-embedded specimens from 161 patients with curatively resected Dukes" C CRC and at least 5-year follow-up periods.	Paraffin	89-97	insulin like growth factor 1 receptor	Homo sapiens	54-60
15634444-0	2004	[Detection of ASPL-TFE3 fusion gene by reverse transcriptase polymerase chain reaction in paraffin-embedded tumor tissues of alveolar soft part sarcoma].	Paraffin	90-98	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	14-18
15634444-9	2004	CONCLUSIONS: The expression of ASPL-TFE3 fusion transcripts in paraffin-embedded tumor tissues can serve as an useful molecular marker in the diagnosis of ASPS.	Paraffin	63-71	ASPSCR1 tether for SLC2A4, UBX domain containing	Homo sapiens	31-35
15389905-3	2004	The BCR/ABL fusion gene was detected on a paraffin-embedded tissue section of the lymph node by double-color fluorescence in situ hybridization, indicating an extramedullary hematopoietic tumor of CML origin.	Paraffin	42-50	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	4-11
15363231-4	2004	The expression of Glut1 of all 24 cases was studied in paraffin sections by SP immunohistochemistry.	Paraffin	55-63	solute carrier family 2 member 1	Homo sapiens	18-23
15053933-1	2004	The expression of mRNA encoding interferon-alpha (IFN-alpha) and Mx1 protein was studied, by reverse transcription-polymerase chain reaction and by in-situ hybridization with a non-radioactive digoxigenin-labelled cDNA probe, in formalin-fixed, paraffin wax-embedded lung tissue from pigs experimentally infected with a Korean isolate (North American genotype) of porcine reproductive and respiratory syndrome virus (PRRSV).	Paraffin	245-257	interferon-alpha-14	Sus scrofa	32-48
15279077-4	2004	METHODS: c-Fos-ir was analyzed by immunohistochemical methods in formaline-fixed, paraffin-embedded sections of rat pancreatic beta cells (BCs), in adrenal medullary chromaffin cells (CCs) that are derived from neural crest, in exocrine pancreatic acinar cells (ACs) that are derived from endoderm, and in adrenal cortex zona reticularis cells (RCs) that are derived from mesoderm.	Paraffin	82-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	9-14
15050007-2	2004	PATIENTS AND METHODS: The expression of DCC was evaluated immunohistochemically in 94 paraffin-embedded tumour samples from patients with stage T1, T2, and T3 clear cell RCC.	Paraffin	86-94	DCC netrin 1 receptor	Homo sapiens	40-43
15024701-4	2004	The potential importance of overproduction of protein products in neoplastic development, led us also to study a possible high expression of cdk4, mdm2 and gli proteins in immunohistochemical staining experiments on paraffin-embedded tissue samples of the same cases.	Paraffin	216-224	GLI family zinc finger 1	Homo sapiens	156-159
15084843-3	2004	The immunohistochemical distribution of c-mos in 159 cases of gynecological lesions and 26 germ cell tumors using formalin-fixed, paraffin-embedded tissues was evaluated.	Paraffin	130-138	MOS proto-oncogene, serine/threonine kinase	Homo sapiens	40-45
15332592-0	2004	The expression of CD44 in archival paraffin embedded interface tissues of failed orthopaedic implants.	Paraffin	35-43	CD44 molecule (Indian blood group)	Homo sapiens	18-22
14967753-4	2004	INTERVENTIONS: Annexin A1 expression was examined with a standard immunohistochemical protocol on paraffin-embedded sections.	Paraffin	98-106	annexin A1	Homo sapiens	15-25
15491060-5	2004	An indirect immunoperoxidase method was applied using polyclonal antibodies against HSP70 and HSP90 on formalin-fixed paraffin-embedded tissues.	Paraffin	118-126	heat shock protein family A (Hsp70) member 4	Homo sapiens	84-89
15195704-5	2004	Paraffin tissue sections were immunostained using CD44 antibody (DAKO).	Paraffin	0-8	CD44 molecule (Indian blood group)	Homo sapiens	50-54
14728832-4	2003	The expression of Glut1 of all the 23 cases was analysed in paraffin sections using SP immunohistochemistry.	Paraffin	60-68	solute carrier family 2 member 1	Homo sapiens	18-23
14576474-8	2003	Mesothelin expression was evaluated in formalin-fixed, paraffin-embedded samples of normal tissues and in 471 tumors of various origins.	Paraffin	55-63	mesothelin	Homo sapiens	0-10
14690578-2	2003	METHODS: Immunohistochemical method was used to detect the expression of B-cell-specific activator protein (BSAP) and CD(20) in 33 paraffin-embedded tissues of classical Hodgkin lymphoma (cHL).	Paraffin	131-139	paired box 5	Homo sapiens	73-106
14690578-2	2003	METHODS: Immunohistochemical method was used to detect the expression of B-cell-specific activator protein (BSAP) and CD(20) in 33 paraffin-embedded tissues of classical Hodgkin lymphoma (cHL).	Paraffin	131-139	paired box 5	Homo sapiens	108-112
13679456-0	2003	Tyrosinase RT-PCR as a supplement to histology for detecting melanoma and nevus cells in paraffin sections of sentinel lymph nodes.	Paraffin	89-97	tyrosinase	Homo sapiens	0-10
13679456-2	2003	We have established an efficient method for extraction and reverse transcription of tyrosinase mRNA from paraffin sections that permits the close correlation of the RT-PCR results with (immuno)histologic findings in adjacent sections.	Paraffin	105-113	tyrosinase	Homo sapiens	84-94
12960741-0	2003	Quantitation of dihydropyrimidine dehydrogenase (DPD) mRNA expression levels in normal colon and colorectal cancer tumor paraffin-embedded tissue specimens.	Paraffin	121-129	dihydropyrimidine dehydrogenase	Homo sapiens	16-47
12960741-0	2003	Quantitation of dihydropyrimidine dehydrogenase (DPD) mRNA expression levels in normal colon and colorectal cancer tumor paraffin-embedded tissue specimens.	Paraffin	121-129	dihydropyrimidine dehydrogenase	Homo sapiens	49-52
12901278-4	2003	The DCC protein was detected with immunohistochemistry using an anti-DCC monoclonal antibody on paraffin-embedded sections.	Paraffin	96-104	DCC netrin 1 receptor	Homo sapiens	4-7
12645345-1	2003	We performed an immunohistochemical analysis of CXCR4/CD184 expression in frozen and paraffin-embedded sections of human peripheral T-cell lymphomas that exhibit a composite Th1 T-cell-like or Th2 T-cell-like immunophenotype, based on expression of Th1-associated markers (CXCR3, OX40/CD134, and CD69) and Th2-associated markers (CD30 and CCR4).	Paraffin	85-93	C-X-C motif chemokine receptor 4	Homo sapiens	48-53
12651235-2	2003	METHODS: Immunohistochemical staining was used to examine the expressions of LMP1, bcl-2, and p53 proteins in 31 paraffin-embedded tissue samples from Hodgkin"s lymphoma.	Paraffin	113-121	PDZ and LIM domain 7	Homo sapiens	77-81
12548159-6	2003	CDX-2 expression was evaluated in formalin-fixed, paraffin-embedded samples of normal adult human tissues (50 samples) and in 299 surgically resected carcinomas of different origins, including 125 non-lung adenocarcinomas, 117 primary lung tumors, 5 mesotheliomas, and 52 adenocarcinomas metastatic to the lung.	Paraffin	50-58	caudal type homeobox 2	Homo sapiens	0-5
12552081-1	2003	We established a quantitative real-time RT-PCR assay for the detection of chimeric BCR-ABL transcripts in archival formalin-fixed bone marrow trephines, both acrylate-embedded and paraffin-embedded.	Paraffin	180-188	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	83-90
12594387-8	2002	Immunohistochemical analyses performed on paraffin embedded tissue sections have shown positive ALK expression with cytoplasmic localization in half of the IMT cases containing the molecular ALK rearrangement.	Paraffin	42-50	ALK receptor tyrosine kinase	Homo sapiens	96-99
12439912-3	2002	The expression of Flt-1 and KDR in paraffin-embedded specimens of gastric cancer was determined by immunohistochemistry.	Paraffin	35-43	kinase insert domain receptor	Homo sapiens	28-31
12397273-6	2002	Mutation of the K-ras gene was analyzed with the polymerase chain reaction-restriction fragment length polymorphism method by using DNA from microdissected tissue in paraffin sections.	Paraffin	166-174	KRAS proto-oncogene, GTPase	Homo sapiens	16-21
12429794-3	2002	In this study, we proceeded to the evaluation of stromelysin-3 protein"s expression in paraffin sections of 133 cases of invasive breast carcinomas and statistically estimated its relations with known clinicopathological prognostic parameters and patients" survival, proliferation markers Ki-67 and TopoIIalpha and the antiapoptotic protein bcl-2.	Paraffin	87-95	matrix metallopeptidase 11	Homo sapiens	49-62
12374690-4	2002	The monoclonal anti-PBR antibody 8 D7 was used for immunohistochemical examination of paraffin-embedded sections.	Paraffin	86-94	translocator protein	Homo sapiens	20-23
12351664-2	2002	RT-PCR for the decalcified paraffin sections indicated expression of MMP-8 and MMP-13 in the periodontal tissues.	Paraffin	27-35	matrix metallopeptidase 13	Rattus norvegicus	79-85
12508547-4	2002	METHODS: The expressions of MMP-9 and VEGF were detected on paraffin-embedded samples from 51 cases of OSCC, 10 cases of oral squamous cell papilloma, and 10 of normal oral mucosa by immunohistochemistry.	Paraffin	60-68	matrix metallopeptidase 9	Homo sapiens	28-33
12131162-2	2002	We report a new case in which we demonstrated the presence of the dermatofibrosarcoma protuberans-specific COL1A1-PDGFB fusion from paraffin-embedded tissue.	Paraffin	132-140	collagen type I alpha 1 chain	Homo sapiens	107-113
12131162-2	2002	We report a new case in which we demonstrated the presence of the dermatofibrosarcoma protuberans-specific COL1A1-PDGFB fusion from paraffin-embedded tissue.	Paraffin	132-140	platelet derived growth factor subunit B	Homo sapiens	114-119
12019169-8	2002	To verify the overexpression in patient samples, two of the overexpressed genes, c-Myc and Rad51, were selected to undergo analysis by reverse transcription-PCR in frozen tumor tissues and by immunostaining in paraffin-embedded tissue section microarrays.	Paraffin	210-218	RAD51 recombinase	Homo sapiens	91-96
11923250-12	2002	The quantification of glial cells in paraffin-processed glaucomatous retinas exhibited a profound increase in density and a significant increase of GFAP immunoreactivity in contrast to the lightly stained glial cells in normal retinas.	Paraffin	37-45	glial fibrillary acidic protein	Homo sapiens	148-152
12133415-3	2002	The paraffin sections were used to determine apoptotic cells by TdT-mediated dUTP-biotin nick end labeling method, to identify bcl-2, bax, fas, fasL and proliferating cell nuclear antigen (PCNA) by immunohistochemistry, to demonstrate fas and fasL mRNA by in situ hybridization.	Paraffin	4-12	DNA nucleotidylexotransferase	Homo sapiens	64-67
11857405-6	2002	This anti-eIF4G-1 antibody was suitable for the immunohistochemistry of paraffin-embedded tissues.	Paraffin	72-80	eukaryotic translation initiation factor 4 gamma 1	Homo sapiens	10-17
11803274-3	2002	In this study, we used a paraffin-reactive antibody directed against CD7 to determine its range of expression in MF and to compare these results with those in controls.	Paraffin	25-33	CD7 molecule	Homo sapiens	69-72
11865631-5	2002	Immunohistochemical study with KM1915 might be a clinically useful method to evaluate the expression of DPD in paraffin-embedded materials.	Paraffin	111-119	dihydropyrimidine dehydrogenase	Homo sapiens	104-107
11924705-4	2002	The way the incident happened remained unclear and the immunohistochemical detection of ABO incompatible erythrocytes in formaldehyde-fixed paraffin-embedded kidney, lung, liver and spleen tissue provided the only material evidence of the transfusion error.	Paraffin	140-148	ABO, alpha 1-3-N-acetylgalactosaminyltransferase and alpha 1-3-galactosyltransferase	Homo sapiens	88-91
11800658-2	2002	These cytoplasmic structures were immunoreactive with antibodies against chromogranin A and synaptophysin in paraffin-embedded tissue.	Paraffin	109-117	synaptophysin	Homo sapiens	92-105
12515996-5	2002	Immunohistochemical analysis for CD44s was carried out in 49 paraffin-fixed sections of neoplastic colorectal tissues and non-neoplastic ones adjacent to the lesion, by the standard peroxidase-antiperoxidase method.	Paraffin	61-69	CD44 molecule (Indian blood group)	Homo sapiens	33-37
12474536-4	2002	To investigate the role of these biomarkers in renal cancer, we analyzed the immunohistochemical distribution of CD44"s expression on formalin fixed paraffin embedded tissue from 67 renal cell carcinomas and correlated with clinicopathologic parameters as well as with p53 suppressor gene expression.	Paraffin	149-157	CD44 molecule (Indian blood group)	Homo sapiens	113-117
11759053-0	2001	A new monoclonal anti-CD7 antibody reactive on paraffin sections.	Paraffin	47-55	CD7 molecule	Homo sapiens	22-25
11684968-0	2001	Reduced sensitivity of paraffin-based RT-PCR assays for ETV6-NTRK3 fusion transcripts in morphologically defined infantile fibrosarcoma.	Paraffin	23-31	neurotrophic receptor tyrosine kinase 3	Homo sapiens	61-66
11607814-5	2001	This achievement was enhanced by the availability of specific antibodies that recognize ALK fusion proteins in paraffin-embedded lymphoma tissues.	Paraffin	111-119	ALK receptor tyrosine kinase	Homo sapiens	88-91
11511839-0	2001	Evaluation of a new paraffin-reactive CD7 T-cell deletion marker and a polymerase chain reaction-based T-cell receptor gene rearrangement assay: implications for diagnosis of mycosis fungoides in community clinical practice.	Paraffin	20-28	CD7 molecule	Homo sapiens	38-41
11511087-3	2001	To further understand the functional expression of VEGF receptors by nonendothelial cells, our preliminary screening detected the expression of VEGFR-2 in 115 different paraffin-embedded cancer specimens including 35 cases of bladder tumor, 30 cases of breast cancer, 25 cases of intestinal cancer, and 25 cases of lung cancer with immunohistochemistry.	Paraffin	169-177	kinase insert domain receptor	Homo sapiens	144-151
11442661-2	2001	METHODS: Apoptosis was detected by using terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) technique in 34 formalin-fixed and paraffin-embedded specimens of renal pelvic and ureteral TCC.	Paraffin	167-175	DNA nucleotidylexotransferase	Homo sapiens	80-83
11376024-3	2001	METHODS: Four commercially available anti-BRCA1 antibodies were used on 45 paraffin wax embedded tumoral samples from patients with (seven of 45) and without (38 of 45) BRCA1 germline mutations.	Paraffin	75-87	BRCA1 DNA repair associated	Homo sapiens	42-47
11406664-10	2001	With microdissection analysis using paraffin-embedding lung tissues, LOH of the TSC2 gene preliminarily was detected in a LAM lesion but not in MMPH.	Paraffin	36-44	TSC complex subunit 2	Homo sapiens	80-84
11378576-0	2001	Paraffin immunoreactivity of CD10, CDw75, and Bcl-6 in follicle center cell lymphoma.	Paraffin	0-8	BCL6 transcription repressor	Homo sapiens	46-51
11407476-4	2001	The mean MIB-1 immunopositivity (MIB-1mean) was evaluated immunohistometrically on paraffin sections using a TV image analysis system CM-2 (Hund, Wetzlar, Germany).	Paraffin	83-91	MIB E3 ubiquitin protein ligase 1	Homo sapiens	9-14
11290539-2	2001	In this study, we have evaluated neurofibromatosis type 2 (NF2) gene alterations in eight PNTs using archival formaldehyde-fixed, paraffin-embedded tissue.	Paraffin	130-138	NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor	Homo sapiens	59-62
11289281-4	2001	METHODS: Mutation screening of the hot spots of the K-ras gene and of the evolutionarily conserved regions of the TP53 gene was performed by denaturing gradient gel electrophoresis technique in formalin-fixed paraffin-embedded specimens of 55 consecutive patients with Dukes C colon cancer treated with adjuvant 5-fluorouracil-based chemotherapy.	Paraffin	209-217	KRAS proto-oncogene, GTPase	Homo sapiens	52-57
11150857-3	2001	The present study aims to localize the TGF alpha transcripts in rat and human embryonic kidneys using a nonradioactive in situ hybridization method on paraffin-embedded embryonic samples.	Paraffin	151-159	transforming growth factor alpha	Rattus norvegicus	39-48
11270550-5	2001	METHODS: MIB-1 SIs were assessed on paraffin-embedded sections of 14 pediatric meningiomas (patient age, 2-17 yr), 5 of which contained atypical or malignant features.	Paraffin	36-44	MIB E3 ubiquitin protein ligase 1	Homo sapiens	9-14
11838744-3	2001	In the present study, we investigated the immunohistochemical expression of CD30 antigen in 15 paraffin-embedded placentas from fetuses after spontaneous abortion in the first trimester of gestation (8th, 10th, and 12th week, respectively) using the monoclonal antibody Ber-H2.	Paraffin	95-103	TNF receptor superfamily member 8	Homo sapiens	76-80
11169510-0	2001	Expression of gp100, MART-1, tyrosinase, and S100 in paraffin-embedded primary melanomas and locoregional, lymph node, and visceral metastases: implications for diagnosis and immunotherapy.	Paraffin	53-61	melan-A	Homo sapiens	21-49
11189940-8	2000	Glut-1 expression was studied in terms of the immunohistochemistry of paraffin sections using anti-Glut-1 antibody to determine the intensity (0-3) of Glut-1 immunoreactivity and percentage of the Glut-1-positive area.	Paraffin	70-78	solute carrier family 2 member 1	Homo sapiens	0-6
11832196-3	2000	A DIG-labeled method of in situ hybridisation (ISH) was used to measure semiquantitatively MTA 1 mRNA in formalin-fixed, paraffin-embedded sections.	Paraffin	121-129	metastasis associated 1	Homo sapiens	91-96
11051374-4	2000	Mutation detection of the KRAS and TP53 genes was performed on paraffin-embedded tumor material, using denaturating gradient gel electrophoresis.	Paraffin	63-71	KRAS proto-oncogene, GTPase	Homo sapiens	26-30
10975921-2	2000	DESIGN: Tenascin expression was evaluated in 75 formalin-fixed, paraffin-embedded biopsy and surgical specimens of the uterine cervix.	Paraffin	64-72	tenascin C	Homo sapiens	8-16
11039671-5	2000	In this study, we analyzed the sequence within the carboxy terminal end of the LMP-1 gene in paraffin-embedded specimens from T-cell lymphomas, Hodgkin"s disease (HD), and the buffy coat of peripheral blood from healthy individuals in Japan.	Paraffin	93-101	PDZ and LIM domain 7	Homo sapiens	79-84
10931221-7	2000	CONCLUSION: This simplified immunostaining method using anti-CD3 and anti-CD8 antibodies on paraffin sections can distinguish active coeliac disease from refractory sprue and should prove useful in clinical practice.	Paraffin	92-100	CD8a molecule	Homo sapiens	74-77
11218674-4	2000	An experiment was carried out to search the expression of CXCR4 retrospectively in FIV (CrFK) infected cat brain tissues using immunohistochemically in the formalin fixed paraffin sections against 12G5, a mouse monoclonal antibody to CXCR4.	Paraffin	171-179	C-X-C motif chemokine receptor 4	Homo sapiens	58-63
10917172-2	2000	We studied the expression of TN in a series of 35 squamous cell invasive carcinomas of the larynx, 13 in situ carcinomas, 41 cases of dysplasia, 10 papillomas and 18 cases of keratosis using the monoclonal antibody TN2 on paraffin-embedded tissue.	Paraffin	222-230	tenascin C	Homo sapiens	29-31
10762653-2	2000	We have immunohistochemically examined the TN-C expression of 33 primary osteosarcoma paraffin-embedded samples.	Paraffin	86-94	tenascin C	Homo sapiens	43-47
10847469-5	2000	In situ hybridization with EBER-1 probe and immunostaining with anti latent membrane protein-1 (LMP-1) antibody was performed on the paraffin sections.	Paraffin	133-141	PDZ and LIM domain 7	Homo sapiens	96-101
10775576-6	2000	Quantitative immunohistochemical evaluation of cellular tPA immunoreactivity was performed on paraffin-embedded 5-microm vascular sections.	Paraffin	94-102	chromosome 20 open reading frame 181	Homo sapiens	56-59
12828172-2	2000	METHODS: The levels of TIMP-3 and TIMP-4 mRNA in paraffin-embedded breast carcinoma specimens from 70 patients with primary invasive breast cancer who had undergone radical mastectomy from January of 1984 to December of 1985 were assessed by in situ hybridization assay.	Paraffin	49-57	TIMP metallopeptidase inhibitor 3	Homo sapiens	23-29
10782467-0	2000	T311--an anti-tyrosinase monoclonal antibody for the detection of melanocytic lesions in paraffin embedded tissues.	Paraffin	89-97	tyrosinase	Homo sapiens	14-24
10595700-0	1999	Microwave-stimulated recovery of myosin-V immunoreactivity from formalin-fixed, paraffin-embedded human CNS.	Paraffin	80-88	myosin VA	Homo sapiens	33-41
10493952-1	1999	The presence of RON and its variant isoform in malignant and non-malignant human colonic tissues was examined by immunohistochemistry using paraffin-embedded sections and RT-PCR analysis followed by direct sequencing of PCR product using RNAs isolated from frozen tissues.	Paraffin	140-148	macrophage stimulating 1 receptor	Homo sapiens	16-19
10478663-9	1999	CD68 immunohistochemistry on paraffin-embedded sections showed many histiocytes and plasmacytoid monocytes in all cases, whereas CD3, CD4, and CD8 showed highly variable staining among the cases.	Paraffin	29-37	CD68 molecule	Homo sapiens	0-4
10442462-9	1999	Using genomic DNA extracted from archival paraffin-embedded sections in the frontal lobe, cerebral basal ganglia and cerebellum, the identical mild CAG-repeat expansions in the CACNL1A4/SCA6 gene were revealed in all samples examined.	Paraffin	42-50	calcium voltage-gated channel subunit alpha1 A	Homo sapiens	186-190
10365929-12	1999	Immunohistochemical analysis on paraffin sections using a large panel of antibodies (16 lesions: AML: 13; CML: 3) showed strong reactivity for LCA (CD45), lysozyme, myeloperoxidase (MPD), LN2 (CD74), HLA-DR, and MT1 (CD43) in the majority of cases, and variable staining for monocyte/macrophage markers (KP1/CD68, PGM1/CD68, Mac387, Ki-M1p).	Paraffin	32-40	protein tyrosine phosphatase receptor type C	Homo sapiens	148-152
10389623-5	1999	In-paraffin sections of 40 kinds of nonneoplastic tissues, epithelium of the small and large intestine, bile duct, nasal mucosa, kidney and adrenal cortex stained positively with both MP-1 and NF-2 antibodies.	Paraffin	3-11	late endosomal/lysosomal adaptor, MAPK and MTOR activator 3	Homo sapiens	184-197
10234450-0	1999	Non-isotopic in situ hybridization of CD44 transcript in formalin-fixed paraffin-embedded sections.	Paraffin	72-80	CD44 molecule (Indian blood group)	Homo sapiens	38-42
10234450-1	1999	We established a protocol for the non-isotopic in situ detection of adhesion molecule CD44 messenger RNA (mRNA) in archival formalin-fixed paraffin-embedded sections of human surgical materials.	Paraffin	139-147	CD44 molecule (Indian blood group)	Homo sapiens	86-90
10370643-3	1999	METHODOLOGY: We assessed the expression pattern and the prognostic impact of beta 1 integrins in paraffin-embedded specimens of 41 patients with adenocarcinoma of Barrett"s esophagus by immunochemistry.	Paraffin	97-105	integrin subunit beta 1	Homo sapiens	77-93
9831208-0	1998	A new Mel-CAM (CD146)-specific monoclonal antibody, MN-4, on paraffin-embedded tissue.	Paraffin	61-69	melanoma cell adhesion molecule	Homo sapiens	15-20
9849582-3	1998	The expression of CD44 variants was evaluated immunohistochemically in paraffin-embedded pancreatic cancer tissues from 42 patients who were confirmed surgically and histologically to have received curative resection.	Paraffin	71-79	CD44 molecule (Indian blood group)	Homo sapiens	18-22
9716554-5	1998	Follistatin was localized using immunohistochemical labeling of paraffin sections, and relative amounts were quantitated using densitometric analysis.	Paraffin	64-72	follistatin	Bos taurus	0-11
9699551-5	1998	The time-dependent expressions of E-selectin in EIU in the iris- ciliary body and the retina were studied by immunohistochemistry using wholemounts and paraffin-embedded sections and by monitoring the level of E-selectin mRNA expression.	Paraffin	152-160	selectin E	Rattus norvegicus	34-44
9699551-10	1998	RESULTS: E-selectin immunoreactivity was observed on the vessel walls of the iris and retina 7 hours after LPS treatment in wholemounts and paraffin-embedded sections and remained positive for 24 hours after LPS treatment.	Paraffin	140-148	selectin E	Rattus norvegicus	9-19
9720495-5	1998	Microwave pretreatment was necessary for anti-MART-1 staining on paraffin-embedded material.	Paraffin	65-73	melan-A	Homo sapiens	46-52
9823779-2	1998	Formalin-fixed, paraffin-embedded sections from 34 patients with cervical adenocarcinoma or adenosquamous carcinoma were immunostained with monoclonal antibody MIB1, expressed in proliferating cells, and anti-nm23 antibody, reacts with metastasis suppression gene products.	Paraffin	16-24	MIB E3 ubiquitin protein ligase 1	Homo sapiens	160-164
9635540-2	1998	This study used MIB-1 monoclonal antibody, a proliferative marker that can be used in formalin fixed paraffin embedded tissues, to study nonpilocytic pediatric astrocytoma.	Paraffin	101-109	MIB E3 ubiquitin protein ligase 1	Homo sapiens	16-21
9650699-1	1998	The expression of c-fos protein was studied in formalin-fixed, paraffin-embedded sections of 11 compound Spitz nevi (SNs), 16 ordinary compound melanocytic nevi (MNs), and 17 malignant melanomas (MMs) using monoclonal antibody MAB1283 and an immunoperoxidase technique.	Paraffin	63-71	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
9630173-6	1998	Genetic study, performed using polymerase chain reaction from paraffin sections, showed a loss of heterozygosity at the TSC2-containing region on 16p in one case, and on 3p in two cases, showing that multiple genetic alterations are taking place in these tumors.	Paraffin	62-70	TSC complex subunit 2	Homo sapiens	120-124
9619566-2	1998	The aim of this study was to use immunohistochemistry to describe the vascular and glandular expression of integrin alpha(v)beta3 in formalin fixed, paraffin embedded endometrium obtained from women with (n = 29) and without (n = 24) endometriosis.	Paraffin	149-157	integrin subunit alpha V	Homo sapiens	107-129
9609139-0	1998	Tyrosinase immunoreactivity in formalin-fixed, paraffin-embedded primary and metastatic melanoma: frequency and distribution.	Paraffin	47-55	tyrosinase	Homo sapiens	0-10
9646029-0	1998	Detection of tyrosinase mRNA in formalin-fixed, paraffin-embedded archival sections of melanoma, using the reverse transcriptase in situ polymerase chain reaction.	Paraffin	48-56	tyrosinase	Homo sapiens	13-23
9646029-9	1998	It is possible to detect tyrosinase mRNA in formalin-fixed, paraffin-embedded tissue sections of melanoma, but the technique remains too demanding for routine application.	Paraffin	60-68	tyrosinase	Homo sapiens	25-35
9467469-2	1998	MATERIALS AND METHODS: Apoptosis was detected by using the terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick-end labelling (TUNEL) technique in 70 formalin-fixed and paraffin-embedded RCC specimens.	Paraffin	186-194	DNA nucleotidylexotransferase	Homo sapiens	98-101
9415414-7	1997	Double-labeling on paraffin sections for both this method and TUNEL revealed that cells become Annexin V-biotin labeled early during the process of apoptosis.	Paraffin	19-27	annexin A5	Mus musculus	95-104
9459631-6	1997	Immunohistochemical analysis of TSHR-like reactivity in paraffin-embedded thymus, adrenal, and kidney revealed specific staining in each of these tissues.	Paraffin	56-64	thyroid stimulating hormone receptor	Homo sapiens	32-36
9352815-2	1997	The specificity of the monoclonal antibody, MIB-1, against the Ki-67 antigen has been established by immunostaining of formalin-fixed paraffin-embedded tissue in a microwave oven.	Paraffin	134-142	MIB E3 ubiquitin protein ligase 1	Homo sapiens	44-49
9293783-4	1997	The GLUT expression was studied by immunohistochemistry of paraffin sections from these tumors after operation using anti-GLUT-1, -2, -3, -4 and -5 antibodies to obtain immunohistochemical grading ("strong," "weak" and "negative") by three experienced physicians.	Paraffin	59-67	solute carrier family 2 member 1	Homo sapiens	4-8
9269897-5	1997	To further identify specific cell types that expressed Par-4, we performed an immunohistochemical analysis of the protein in paraffin-embedded sections of various organs from rats.	Paraffin	125-133	pro-apoptotic WT1 regulator	Rattus norvegicus	55-60
9224380-2	1997	MATERIALS AND METHODS: A monoclonal antibody (MIB-1) developed for application in paraffin-embedded tissues was used to measure immunohistochemical expression of Ki-67 for the overall tumor (total MIB-1) and for each malignant cell type present.	Paraffin	82-90	MIB E3 ubiquitin protein ligase 1	Homo sapiens	46-51
9267818-4	1997	The MIB-1 antibody permits the immunohistochemical detection of the Ki67 antigen in fixed and paraffin-embedded tissue sections.	Paraffin	94-102	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-9
9177704-3	1997	It was applied to analyze mutations in codon 12 of the K-ras gene in 43 tissue sites microdissected from paraffin-embedded sections obtained from 8 archival cases of lung cancer, all previously shown to have codon 12 K-ras mutations by direct sequencing.	Paraffin	105-113	KRAS proto-oncogene, GTPase	Homo sapiens	55-60
9141559-1	1997	We evaluated the occurrence, tissue distribution, and prognostic value of tumor-associated macrophages in 121 papillary thyroid carcinomas using immunohistochemical staining with anti-CD68 antibody in archival paraffin-embedded sections.	Paraffin	210-218	CD68 molecule	Homo sapiens	184-188
9111386-0	1997	Ki-67 as a prognostic marker in adenoid cystic carcinoma assessed with the monoclonal antibody MIB1 in paraffin sections.	Paraffin	103-111	MIB E3 ubiquitin protein ligase 1	Homo sapiens	95-99
9111386-1	1997	The monoclonal antibody MIB1 recognizing the Ki-67 antigen in formalin-fixed, paraffin-embedded tissue was used to study the proliferative activity in 44 adenoid cystic carcinomas of the salivary glands.	Paraffin	78-86	MIB E3 ubiquitin protein ligase 1	Homo sapiens	24-28
9023396-3	1997	MIB-1 was the proliferation marker used on paraffin sections.	Paraffin	43-51	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
9058292-0	1997	Detection of c-Ki-ras oncogene mutation in gastric adenomas with formalin-fixed, paraffin-embedded biopsy materials.	Paraffin	81-89	KRAS proto-oncogene, GTPase	Homo sapiens	13-21
9047244-3	1997	TN expression was evaluated by immunohistochemistry using paraffin-embedded tissue sections, TN expression levels were correlated with patient age, tumor stage, and survival.	Paraffin	58-66	tenascin C	Homo sapiens	0-2
9006320-5	1997	More intense staining of tuberin, in the cryosections and in paraffin sections, was observed in the small blood vessels of many organs, including the kidney, skin, and adrenal gland.	Paraffin	61-69	TSC complex subunit 2	Homo sapiens	25-32
9332493-10	1997	In conclusion, the MIB-1 antibody provides prognostic information in non-Hodgkin"s lymphomas and has the main advantage that it can be used in formalin-fixed, paraffin-embedded specimens.	Paraffin	159-167	MIB E3 ubiquitin protein ligase 1	Homo sapiens	19-24
8929476-3	1996	The expression of CD44 was investigated with the monoclonal antibody GKW.A3 in prostate cancer in formalin-fixed, paraffin-embedded tissue sections of (1) whole prostates from 50 patients with 74 prostate cancers; and (2) lymph node metastases from 14 patients.	Paraffin	114-122	CD44 molecule (Indian blood group)	Homo sapiens	18-22
8961585-3	1996	The recently released CD8 antiserum required microwave antigen retrieval of formalin-fixed, paraffin-embedded tissue to label lymphocytes.	Paraffin	92-100	CD8a molecule	Homo sapiens	22-25
8950601-1	1996	Constitutive endothelial nitric oxide synthase (NOS III) expression during the oestrous cycle was mapped immunocytochemically on 5 microns-thick paraffin sections of rat female reproductive organs.	Paraffin	145-153	nitric oxide synthase 3	Rattus norvegicus	48-55
8813086-0	1996	Amplification of human beta-actin gene by the reverse transcriptase-polymerase chain reaction: implications for assessment of RNA from formalin-fixed, paraffin-embedded material.	Paraffin	151-159	POTE ankyrin domain family member F	Homo sapiens	23-33
8784279-4	1996	METHODS: MIB-1 reactivity (% total tumor nuclei) was assessed in 34 formalin-fixed, paraffin-embedded primary cutaneous melanomas and correlated with metastatic potential and overall survival (follow-up, 10.5 +/- 1.8 years).	Paraffin	84-92	MIB E3 ubiquitin protein ligase 1	Homo sapiens	9-14
9816271-3	1996	We developed procedures to examine the status of the K-ras gene by ASO-h and by single-strand conformation polymorphism assay of DNA obtained from formalin-fixed paraffin-embedded tumors.	Paraffin	162-170	KRAS proto-oncogene, GTPase	Homo sapiens	53-58
16696063-0	1996	Distribution of CD44 messenger RNA in archival paraffin wax embedded tumours and normal tissues viewed by in situ hybridisation.	Paraffin	47-59	CD44 molecule (Indian blood group)	Homo sapiens	16-20
8666362-4	1996	Paraffin-embedded tissue sections were immunostained with monoclonal antibody to p53 and MDM2 proteins.	Paraffin	0-8	MDM2 proto-oncogene	Homo sapiens	89-93
8623923-5	1996	PG-B6p (p is for paraffin) recognized a fixative-resistant epitope of BCL-6 that was detectable on paraffin sections after microwave heating in 1 mmol/L EDTA buffer.	Paraffin	17-25	BCL6 transcription repressor	Homo sapiens	70-75
8623923-5	1996	PG-B6p (p is for paraffin) recognized a fixative-resistant epitope of BCL-6 that was detectable on paraffin sections after microwave heating in 1 mmol/L EDTA buffer.	Paraffin	99-107	BCL6 transcription repressor	Homo sapiens	70-75
8623923-10	1996	Labeling of paraffin sections with PG-B6p proved useful for differentiating proliferation centers in B-CLL (BCl-2+/BCL-6-) from trapped germinal centers in mantle cell lymphomas (BCL-2-/BCL-6+) and for identifying neoplastic cells in cases of nodular, lymphocyte-predominance Hodgkin"s disease.	Paraffin	12-20	BCL6 transcription repressor	Homo sapiens	115-120
8623923-10	1996	Labeling of paraffin sections with PG-B6p proved useful for differentiating proliferation centers in B-CLL (BCl-2+/BCL-6-) from trapped germinal centers in mantle cell lymphomas (BCL-2-/BCL-6+) and for identifying neoplastic cells in cases of nodular, lymphocyte-predominance Hodgkin"s disease.	Paraffin	12-20	BCL6 transcription repressor	Homo sapiens	186-191
8611709-4	1996	We have investigated LMP1 status in formalin-fixed, paraffin wax-embedded lymph nodes with HD involvement from 53 children and 48 adults from Kenya using immunohistochemical staining.	Paraffin	52-64	PDZ and LIM domain 7	Homo sapiens	21-25
8836295-2	1996	MIB-1 antibody has recently become available, which detects Ki-67 antigen even in the formalin-fixed paraffin-embedded specimens.	Paraffin	101-109	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
8852442-1	1996	A monoclonal antibody, MIB1, recognizes Ki-67 antigen in routinely processed paraffin sections after microwave treatment.	Paraffin	77-85	MIB E3 ubiquitin protein ligase 1	Homo sapiens	23-27
9102728-6	1996	The purpose of this study was to verify the presence of ICAM-1 and VCAM-1 in paraffin-embedded tissue section of seven cases of U-NPC.	Paraffin	77-85	intercellular adhesion molecule 1	Homo sapiens	56-62
7576702-5	1995	Using double immunofluorescence and avidin biotin complex (ABC) techniques on paraffin sections, presence of CD44s and CD44v isoforms (CD44v4, CD44v6, CD44v9) has been analyzed.	Paraffin	78-86	CD44 molecule (Indian blood group)	Homo sapiens	109-113
8568590-3	1995	An immunohistochemical study was undertaken on the expression of standard CD44 (CD44s) and the variant isoforms containing the domains encoded by variant exon 3 (CD44v3) or variant exon 6 (CD44v6) in paraffin-embedded bronchial biopsy specimens from 32 NSCLC cases and 11 SCLC cases.	Paraffin	200-208	CD44 molecule (Indian blood group)	Homo sapiens	74-78
8558846-3	1995	EXPERIMENTAL DESIGN: Using a double-immunolabeling technique (paraffin-reactive MIB1 Ab to determine Ki67 labeling index (Ki67LI) and anti-CD34 to quantify microvessels), we immunostained 20 prostatic carcinomas and adjacent benign prostate hyperplasia (BH) and four cases of trauma-induced granulation tissue.	Paraffin	62-70	MIB E3 ubiquitin protein ligase 1	Homo sapiens	80-84
8669885-3	1995	METHODS: Paraffin sections of 118 breast cancers were immunostained with antibody to Glut1.	Paraffin	9-17	solute carrier family 2 member 1	Homo sapiens	85-90
8574890-2	1995	In the current study, the antigen retrieval technique was used to detect ICAM-1 immunohistochemically in paraffin sections of lungs from human, mouse and rat as well as in bleomycin- or radiation-induced fibrotic lungs from rat and human.	Paraffin	105-113	intercellular adhesion molecule 1	Homo sapiens	73-79
7482737-3	1995	This study was conducted to examine the occurrence of apoptotic cell death in 44 formalin-fixed, paraffin-embedded biopsy specimens from allografted kidneys by the terminal deoxynucleiotidyl transferase (TdT)-mediated D-UTP-biotin nick end labeling (TUNEL) method.	Paraffin	97-105	DNA nucleotidylexotransferase	Homo sapiens	164-202
7482737-3	1995	This study was conducted to examine the occurrence of apoptotic cell death in 44 formalin-fixed, paraffin-embedded biopsy specimens from allografted kidneys by the terminal deoxynucleiotidyl transferase (TdT)-mediated D-UTP-biotin nick end labeling (TUNEL) method.	Paraffin	97-105	DNA nucleotidylexotransferase	Homo sapiens	204-207
7591303-2	1995	We have detected gp78 expression in buffered-formalin-fixed, paraffin-embedded sections of esophageal squamous cell carcinomas using an anti-gp78 monoclonal antibody (MAb), 3F3A, and examined the relationship between gp78 expression and clinicopathological and prognostic factors.	Paraffin	61-69	autocrine motility factor receptor	Homo sapiens	17-21
7567694-2	1995	Statistically significant correlations were found in LNCaP cultures between Ki-67 and MIB-1 scores (r = 0.84, P &lt; 0.001), and in PC-82 tumors between MIB-1 scores and paraffin tissue Ki-67 (pKi-67) (r = 0.90, P &lt; 0.001), frozen tissue (fKi-67) (r = 0.86, P &lt; 0.001), and BrdU uptake (r = 0.70, P &lt; 0.001), respectively.	Paraffin	170-178	MIB E3 ubiquitin protein ligase 1	Homo sapiens	153-158
7567694-6	1995	MIB-1 is a promising means of evaluating the presence of only minute amounts of the Ki-67 antigen in paraffin-embedded human tumor material, especially in relatively slowly growing tumors.	Paraffin	101-109	MIB E3 ubiquitin protein ligase 1	Homo sapiens	0-5
7781791-1	1995	A three-step immunoperoxidase staining technique was used in order to estimate the immunohistochemical expression of K-ras, c-fos, c-myc and c-erbB-2 oncoproteins, in paraffin sections of 20 patients, with histologically proven adenocarcinoma of the pancreas.	Paraffin	167-175	KRAS proto-oncogene, GTPase	Homo sapiens	117-122
7747805-7	1995	Using monoclonal antibodies to EBNA2 and LMP on paraffin sections, we found an expression of both proteins in 2 of 3 polymorphic PTLD and in 7 of 8 cases of monomorphic, large cell PTLD, without plasmacytic differentiation.	Paraffin	48-56	PDZ and LIM domain 7	Homo sapiens	41-44
7766265-3	1995	We studied cellular proliferation in 53 breast carcinomas using quantitative image analysis of immunoreactivity to a recently available monoclonal antibody, MIB-1, which is applicable to formalin-fixed, paraffin-embedded tissues.	Paraffin	203-211	MIB E3 ubiquitin protein ligase 1	Homo sapiens	157-162
8629136-0	1995	Use of PCR-PIRA for screening of a point mutation at codon 12 in K-ras oncogene obtained from paraffin embedded tissue sections.	Paraffin	94-102	KRAS proto-oncogene, GTPase	Homo sapiens	65-70
7873981-2	1994	We have used this technique to detect and locate mRNA for mouse ZP3 protein in paraffin sections of fixed ovaries of newborn and adult mice.	Paraffin	79-87	zona pellucida glycoprotein 3	Mus musculus	64-67
7873981-5	1994	Previous work on the distribution of ZP3 mRNA was confirmed and we were able to show that using non-isotopic in situ hybridization, sensitive and accurate cellular localization was feasible in paraffin embedded mouse ovary.	Paraffin	193-201	zona pellucida glycoprotein 3	Mus musculus	37-40
8082097-9	1994	The proliferation index with proliferating cell nuclear antigen (PCNA) monoclonal antibody was 75.78%, whereas it was only 4.22% with Ki67 monoclonal antibodies adopted to paraffin material (MIB-1).	Paraffin	172-180	MIB E3 ubiquitin protein ligase 1	Homo sapiens	191-196
7927875-1	1994	The expression level of stromelysin-3 (ST3) mRNA was analyzed by in situ hybridization of formalin-fixed, paraffin-embedded primary breast-tumor samples from 76 patients.	Paraffin	106-114	matrix metallopeptidase 11	Homo sapiens	24-37
7927875-1	1994	The expression level of stromelysin-3 (ST3) mRNA was analyzed by in situ hybridization of formalin-fixed, paraffin-embedded primary breast-tumor samples from 76 patients.	Paraffin	106-114	matrix metallopeptidase 11	Homo sapiens	39-42
8085550-0	1994	Paraffin-resistant antigens detectable by antibodies L26 and polyclonal CD3 predict the B- or T-cell lineage of 95% of diffuse aggressive non-Hodgkin"s lymphomas.	Paraffin	0-8	ribosomal protein L26	Homo sapiens	53-56
8042584-11	1994	The advantages of MIB1 immunostaining on paraffin sections include the feasibility of retrospective studies and of obtaining clear morphologic specimens that are optimal for use with computer-assisted image analysis systems.	Paraffin	41-49	MIB E3 ubiquitin protein ligase 1	Homo sapiens	18-22
8078299-4	1994	EXPERIMENTAL DESIGN: By use of antibodies specific to peripherin and NF-66/alpha-internexin, we detected these proteins on Western blots of NB tissue extracts and in paraffin sections of NBs.	Paraffin	166-174	internexin neuronal intermediate filament protein alpha	Homo sapiens	69-74
7524650-4	1994	We examined the distribution of tenascin, especially in the stroma near basement membranes, in paraffin sections from 25 patients with gastric cancer by immunohistological staining with regard to tumor staging, grading and Lauren classification.	Paraffin	95-103	tenascin C	Homo sapiens	32-40
7937725-0	1994	Terminal deoxynucleotidyl transferase staining of malignant lymphomas in paraffin sections.	Paraffin	73-81	DNA nucleotidylexotransferase	Homo sapiens	0-37
7937725-3	1994	We have obtained satisfactory staining for TdT in routinely processed paraffin sections using a recently described antigen retrieval pretreatment based on microwave oven heating of the sections and a polyclonal rabbit anti-TdT serum.	Paraffin	70-78	DNA nucleotidylexotransferase	Homo sapiens	43-46
7937725-8	1994	Specificity was further confirmed by demonstrating TdT-positive blasts in paraffin sections of bone marrow biopsies from 44 patients with TdT-positive (by indirect immunofluorescence) acute leukemias and in paraffin sections of extramedullary leukemic infiltrates from eight patients with relapsed acute lymphoblastic leukemia.	Paraffin	74-82	DNA nucleotidylexotransferase	Homo sapiens	51-54
7937725-8	1994	Specificity was further confirmed by demonstrating TdT-positive blasts in paraffin sections of bone marrow biopsies from 44 patients with TdT-positive (by indirect immunofluorescence) acute leukemias and in paraffin sections of extramedullary leukemic infiltrates from eight patients with relapsed acute lymphoblastic leukemia.	Paraffin	207-215	DNA nucleotidylexotransferase	Homo sapiens	51-54
7931834-1	1994	Immunohistochemical study of 30 cases using the MIB 1 antibody in formalin-fixed paraffin sections.	Paraffin	81-89	MIB E3 ubiquitin protein ligase 1	Homo sapiens	48-53
7931834-4	1994	The MIB 1 monoclonal antibody recognizes the Ki-67 antigen in formalin-fixed, paraffin-embedded tissues.	Paraffin	78-86	MIB E3 ubiquitin protein ligase 1	Homo sapiens	4-9
7509720-3	1994	We have examined the expression of CD44 in 12 human lung tumor cell lines and 23 fixed, paraffin-embedded lung cancers.	Paraffin	88-96	CD44 molecule (Indian blood group)	Homo sapiens	35-39
7911996-1	1994	Simultaneous detection of intercellular adhesion molecules-1 (ICAM-1) and carcinoembryonic antigen (CEA) was investigated in AMeX (Acetone, Methyl benzoate and Xylene)-fixed, paraffin-embedded tumor sections of 24 adenocarcinomas of the lung, using the avidin-biotin-peroxidase complex (ABC) method.	Paraffin	175-183	intercellular adhesion molecule 1	Homo sapiens	62-68
8305484-5	1994	Immunochemistry of paraffin sections of fetal membranes, revealed the presence of both SP-A and SP-D in the amniotic epithelium and chorio-decidual layers.	Paraffin	19-27	surfactant protein D	Homo sapiens	96-100
7513322-2	1994	Using this probe, an in situ hybridization protocol was established, tested and optimized for the localization of the cytokeratin 4 mRNA in formalin- or paraformaldehyde-fixed, paraffin-embedded human oesophageal mucosa.	Paraffin	177-185	keratin 4	Homo sapiens	118-131
8288680-0	1994	Detection of MDM2-proto-oncogene in paraffin embedded human bronchial epithelium.	Paraffin	36-44	MDM2 proto-oncogene	Homo sapiens	13-17
8288680-6	1994	Here we describe the successful use of a monoclonal antibody (IF2) for the detection of MDM2 protein in paraffin-embedded tissue from human lung biopsies.	Paraffin	104-112	MDM2 proto-oncogene	Homo sapiens	88-92
7983374-3	1994	Immunocytochemistry on paraffin sections at postnatal days (P) 7, 14, 21, 30 and 60 showed that the density of CCK neurons in all visual areas of both groups of animals progressively increases from P7 to P21 but declines thereafter, to reach 50-75% of peak densities at P30.	Paraffin	23-31	cholecystokinin	Rattus norvegicus	111-114
8406434-0	1993	Retrospective molecular detection of Transthyretin Met 111 mutation in a Danish kindred with familial amyloid cardiomyopathy, using DNA from formalin-fixed and paraffin-embedded tissues.	Paraffin	160-168	transthyretin	Homo sapiens	37-50
8352531-1	1993	The immunohistochemical expression of C-myc p62 oncoprotein was investigated using the immunoperoxidase method and the monoclonal antibody (Mab) MYC 1-9E10 in bone marrow paraffin sections.	Paraffin	171-179	nucleoporin 62	Homo sapiens	44-47
8489386-2	1993	To achieve this goal, the presence and specific type of K-ras-2 point mutation was determined from formalin-fixed, paraffin-embedded tissue sites in 247 primary and 166 metastatic-recurrent colorectal adenocarcinomas, using a novel approach consisting of topographic tissue selection, DNA amplification, and direct sequencing applicable to large and needle-biopsy-sized specimens.	Paraffin	115-123	KRAS proto-oncogene, GTPase	Homo sapiens	56-63
8438787-7	1993	These findings show that antibodies UCHL1, beta F1, and L26 can be used to determine the numbers of B and T lymphocytes in paraffin-embedded, formalin-fixed bone marrow specimens and thus may help to distinguish reactive T lymphocytosis from B-cell lymphoma.	Paraffin	123-131	ribosomal protein L26	Homo sapiens	56-59
8419465-4	1993	Rabbit antiserum against the 59 KD rat liver microsomal carboxylesterase bound most prominently to the olfactory mucosa when applied to decalcified, paraffin-embedded sections of rat nasal turbinates.	Paraffin	149-157	carboxylesterase-like 1	Rattus norvegicus	39-72
8237276-0	1993	Analysis of BCR/ABL abnormalities in mRNA from 20-year-old paraffin-embedded tissue for BCR/ABL rearrangement by polymerase chain reaction.	Paraffin	59-67	ABL proto-oncogene 1, non-receptor tyrosine kinase	Homo sapiens	12-19
1479035-5	1992	CD8 positive cells could also be detected in paraffin wax embedded tissues.	Paraffin	45-57	CD8a molecule	Homo sapiens	0-3
1484317-0	1992	Monoclonal antibodies against recombinant parts of the Ki-67 antigen (MIB 1 and MIB 3) detect proliferating cells in microwave-processed formalin-fixed paraffin sections.	Paraffin	152-160	MIB E3 ubiquitin protein ligase 1	Homo sapiens	55-85
1384340-6	1992	The study was extended with the MAb 143DB7 that reacted with tenascin in paraffin sections.	Paraffin	73-81	tenascin C	Homo sapiens	61-69
1562535-1	1992	An in situ hybridization method using paraffin-embedded sections was used to characterize the chicken oviduct cells synthesizing ovalbumin mRNA due to the action of estrogen and progesterone.	Paraffin	38-46	ovalbumin (SERPINB14)	Gallus gallus	129-138
1584959-4	1992	Gliafibrillar acid protein (GFAP) and vimentin proved to be of particularly high stability and, consequently, were easily detectable from paraffin material.	Paraffin	138-146	glial fibrillary acidic protein	Homo sapiens	0-26
1584959-4	1992	Gliafibrillar acid protein (GFAP) and vimentin proved to be of particularly high stability and, consequently, were easily detectable from paraffin material.	Paraffin	138-146	glial fibrillary acidic protein	Homo sapiens	28-32
1516585-4	1992	P21 product of H-ras and P62 product of c-myc genes were detected in paraffin embedded parallel tissue sections.	Paraffin	69-77	nucleoporin 62	Homo sapiens	25-28
1376944-0	1992	Paraffin section immunohistochemistry in the diagnosis of Hodgkin"s disease and anaplastic large cell (CD30+) lymphomas.	Paraffin	0-8	TNF receptor superfamily member 8	Homo sapiens	103-107
1384228-16	1992	In paraffin sections, 46.6% of the cases revealed a distinct positive reaction of some tumour cells with the monoclonal cytokeratin antibody KL1 (molecular weight 55-57 kDa).	Paraffin	3-11	KIT ligand	Homo sapiens	141-144
1654872-6	1991	Glial fibrillary acidic protein expression in chondromyxoid and chordoid tumors was studied in formaldehyde solution-fixed, paraffin-embedded sections of 20 pleomorphic adenomas and 10 chordomas by the immunoperoxidase method with the use of commercially available monoclonal (n = 2) and polyclonal (n = 1) antibodies.	Paraffin	124-132	glial fibrillary acidic protein	Homo sapiens	0-31
1680544-1	1991	An enhanced immunohistochemical procedure to detect proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, has been successfully applied to formalin-fixed, paraffin-embedded archival rat and mouse tissues.	Paraffin	183-191	proliferating cell nuclear antigen	Rattus norvegicus	52-86
1680544-1	1991	An enhanced immunohistochemical procedure to detect proliferating cell nuclear antigen (PCNA), an endogenous cell replication marker, has been successfully applied to formalin-fixed, paraffin-embedded archival rat and mouse tissues.	Paraffin	183-191	proliferating cell nuclear antigen	Rattus norvegicus	88-92
1680544-3	1991	Successful immunohistochemical staining of PCNA can be consistently obtained in tissues fixed for over 24 months in formalin and in sections made from paraffin blocks stored in our tissue archives for up to 19 months.	Paraffin	151-159	proliferating cell nuclear antigen	Rattus norvegicus	43-47
1916699-1	1991	A commercially available monoclonal antibody which detects histiocytes in paraffin sections, Mac387, was reacted with 148 soft tissue sarcomas, 29 carcinomas and 10 malignant melanomas.	Paraffin	74-82	S100 calcium binding protein A9	Homo sapiens	93-99
1711075-4	1991	Like most CD45 antibodies, reactivity can be demonstrated in fresh frozen as well as in formalin-fixed, paraffin-embedded tissues.	Paraffin	104-112	protein tyrosine phosphatase receptor type C	Homo sapiens	10-14
1829834-2	1991	While L26 (CD20) is now well established as a B-cell marker of high specificity for use in paraffin-embedded tissues, paraffin-reactive T-cell antibodies (UCHL1, MT1, Leu-22, DF-T1, and MT2) have not shown comparable lineage specificity.	Paraffin	91-99	ribosomal protein L26	Homo sapiens	6-9
1999523-0	1991	CD45R antigen is expressed on eosinophils in paraffin-embedded tissue sections.	Paraffin	45-53	protein tyrosine phosphatase receptor type C	Homo sapiens	0-5
2056968-0	1991	Analysis of N-ras gene mutations in medulloblastomas by polymerase chain reaction and oligonucleotide probes in formalin-fixed, paraffin-embedded tissues.	Paraffin	128-136	NRAS proto-oncogene, GTPase	Homo sapiens	12-17
2212064-1	1990	The monoclonal antibody KP1 (CD68) was used to stain normal and neoplastic monocytes and macrophages in routinely processed, paraffin wax embedded tissue: mast cells also exhibited strong, consistent cytoplasmic immunoreactivity.	Paraffin	125-137	CD68 molecule	Homo sapiens	29-33
2115647-1	1990	The expression of fos protein was examined in 30 cases of human osteosarcoma as formalin-fixed and paraffin-embedded tissue sections using two monoclonal antibodies and, for five cases, as frozen sections using 3 polyclonal antibodies.	Paraffin	99-107	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-21
2257025-12	1990	Immunochemistry on paraffin sections with UCHL-1, MB-2, LN-1, L-26 showed that 94% were of B-cell nature and only one probably of T-cell origin.	Paraffin	19-27	ribosomal protein L26	Homo sapiens	62-66
34894554-3	2022	It was found that the resulted MoS2/CNF hybrid aerogels demonstrate excellent microwave absorbing performance when the only 5.0 wt% fillers were loaded in paraffin.	Paraffin	155-163	NPHS1 adhesion molecule, nephrin	Homo sapiens	36-39
34799988-0	2022	Response to clinical evaluation of the effectiveness of fusion-induced asymmetric transcription assay-based reverse transcription droplet digital PCR for ALK detection in formalin-fixed paraffin-embedded samples from lung cancer.	Paraffin	186-194	ALK receptor tyrosine kinase	Homo sapiens	154-157
34509039-2	2021	We aimed to compare mRNA expression of RORgammat and IL-17 in paraffin-embedded blocks of OLP and CLP lesions with normal oral mucosa (NOM), and also its correlation with hematologic parameters.	Paraffin	62-70	interleukin 17A	Homo sapiens	53-58
34794218-8	2021	The high protein expression rate of HNF4gamma in paraffin-embedded gastric cancer tissues was 41.2% (42/102), which was significantly higher than 8.8% (9/102) in normal gastric mucosa tissue (P< 0.001).	Paraffin	49-57	hepatocyte nuclear factor 4 gamma	Homo sapiens	36-45
34877472-9	2021	We further demonstrate that these antibodies recognize the AREG neo-epitope in formalin-fixed, paraffin-embedded tumor tissue, suggesting their utility as a companion diagnostic for patient selection.	Paraffin	95-103	amphiregulin	Homo sapiens	59-63
34496167-9	2021	The expression level of Ki-67, CD31 and VEGF were significantly decreased in tumor tissues of the Psoralidin-treated group in comparison with Paraffin-treated group.	Paraffin	142-150	antigen identified by monoclonal antibody Ki 67	Mus musculus	24-29
34496167-9	2021	The expression level of Ki-67, CD31 and VEGF were significantly decreased in tumor tissues of the Psoralidin-treated group in comparison with Paraffin-treated group.	Paraffin	142-150	vascular endothelial growth factor A	Mus musculus	40-44
34392674-7	2021	The tensile strength of SR/Pa@SiO2@PDA-2 can be up to 0.560 MPa, which is 1.85 times higher than the tensile strength of pure SR/Pa@SiO2 because the interface compatibility between Pa@SiO2 microcapsules and SR is improved through hydrogen bonding between the abundant groups on the PDA surface and the matrix.	Paraffin	181-183	transcription factor AP-2 beta	Homo sapiens	35-40
34364401-5	2021	HSPD1 expression was evaluated by immunohistochemistry from formalin-fixed paraffin-embedded tissues from NSCLC patients.	Paraffin	75-83	heat shock protein family D (Hsp60) member 1	Homo sapiens	0-5
34344387-3	2021	This study aimed to validate the Idylla  platform for the detection of EGFR/KRAS mutations in cytological NSCLC samples prepared as cytoblocks using AGAR and paraffin embedding.	Paraffin	158-166	KRAS proto-oncogene, GTPase	Homo sapiens	76-80
34226497-4	2021	In the FFPE (formalin-fixed paraffin-embedded) sections prepared from the colons of ulcerative colitis (UC) and immune-mediated colitis (IRAEC) patients, expression of DCLK1 isoforms correlated positively with Notch1 and negatively with a transcriptional repressor, FoxD3 (Forkhead Box D3).	Paraffin	28-36	doublecortin like kinase 1	Homo sapiens	168-173
34203855-4	2021	In this study, we further improved and calibrated a previously described RAD51-based functional HRD test on 74 diagnostic formalin-fixed paraffin-embedded (FFPE) specimens (RAD51-FFPE test) from endometrial cancer (EC n = 25) and epithelial ovarian cancer (OC n = 49) patients.	Paraffin	137-145	RAD51 recombinase	Homo sapiens	73-78
34092612-4	2021	NNAT was detected in formaldehyde fixed, paraffin embedded primary cancer tissue by immunohistochemistry and an immuno-reactive score (IRS) determined.	Paraffin	41-49	neuronatin	Homo sapiens	0-4
35397317-9	2022	MALAT1-GLI1 fusion was detected in formalin-fixed paraffin-embedded tissue using RT-PCR and Sanger sequencing.	Paraffin	50-58	GLI family zinc finger 1	Homo sapiens	7-11
35574028-4	2022	We observed and quantified the expression of apelin, SDHB, CHGB, ERBB-2, CNTN4, and SUCLG2 in paraffin-embedded samples using immunohistochemical staining.	Paraffin	94-102	succinate dehydrogenase complex iron sulfur subunit B	Homo sapiens	53-57
35574028-4	2022	We observed and quantified the expression of apelin, SDHB, CHGB, ERBB-2, CNTN4, and SUCLG2 in paraffin-embedded samples using immunohistochemical staining.	Paraffin	94-102	contactin 4	Homo sapiens	73-78
35131666-5	2022	PATIENTS AND METHODS: We retrospectively assessed GATA-3 gene expression by quantitative real time PCR (qRT-PCR) from neoplastic biopsies in Formalin-Fixed Paraffin-Embedded samples (FFPE) of 80 patients with nPTCL that were admitted in a single cancer treatment center from 2000 to 2017.	Paraffin	156-164	GATA binding protein 3	Homo sapiens	50-56
35163506-6	2022	Five formalin-fixed paraffin-embedded (FFPE) metastatic PAC specimens were successfully assayed with OCP, and KRAS was the most prevalent alteration, which might contraindicate the use of anti-EGFR therapy.	Paraffin	20-28	KRAS proto-oncogene, GTPase	Homo sapiens	110-114