PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30126274-3	2018	In particular, the N-anilinoethylamide scaffold, previously developed for melatonergic ligands, was decorated at meta position with a polymethylene linker bound to an O-arylcarbamate group, substituted according to known structure-activity relationships for FAAH inhibition.	polymethylene	134-147	fatty-acid amide hydrolase 1	Oryctolagus cuniculus	258-262
11784142-6	2002	Polymethylene bridges linked thiophene C-4 and C-5 of compounds 17a-j, 18a-n, and 19a-o.	polymethylene	0-13	complement C4A (Rodgers blood group)	Homo sapiens	39-42
10774007-1	2000	Use of the intramolecular formation of tricyclooxonium ylides Two types of bicyclic ortho esters 14 and 18, which are tethered to a diazocarbonyl group by polymethylene linkages--(CH2)n--of different lengths (n = 1-3 for 14 and 1-4 for 18), were prepared and catalytically decomposed by treatment with Rh2(OAc)4 either in the presence or absence of a protic nucleophile (MeOH, PhOH, AcOH) to give ring-enlargement product lactones 25 and 30 of different sizes.	polymethylene	155-168	Rh associated glycoprotein	Homo sapiens	302-311
19678668-6	2009	The redox waves of Co(II)/Co(I) in 2a and 2a" were slightly different from those of other complexes because of the short polymethylene chain.	polymethylene	121-134	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	19-25
27891543-9	2016	Density functional theory calculations (B3LYP/6-31G*, LanL2DZ) determined that the structure dependence of the chromogenic behaviour of these non-vaulted and polymethylene-vaulted hydrazone complexes can be attributed to variations in the participation of neighbouring nitrogen lone pairs in the d-pi conjugation on the trans-bis(salicylaldiminato)Pt(ii) coordination platforms.	polymethylene	158-171	protein tyrosine phosphatase non-receptor type 22	Homo sapiens	42-45
19678668-6	2009	The redox waves of Co(II)/Co(I) in 2a and 2a" were slightly different from those of other complexes because of the short polymethylene chain.	polymethylene	121-134	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	26-31
18778798-0	2008	Mechanism of hydrolysis of dicholine esters with long polymethylene chain by human butyrylcholinesterase.	polymethylene	54-67	butyrylcholinesterase	Homo sapiens	83-104
19377526-2	2009	New polymethylene derivatives of nucleic bases with a beta-diketo function in the omega-position were obtained by alkylation of uracil, thymine, cytosine, hypoxanthine, adenine, and N(2)-isobutyryl guanine with 2-omega-chloroal-kanoyl)cyclohexanones.	polymethylene	4-17	amyloid beta precursor protein	Homo sapiens	52-58
18976908-1	2008	Oxazole containing glycine and oximinobutyric acid derivatives were synthesized as PPARalpha agonists by incorporating polymethylene spacer as a replacement of commonly used phenylene group that connects the acidic head with lipophilic tail.	polymethylene	119-132	peroxisome proliferator activated receptor alpha	Homo sapiens	83-92
18976908-4	2008	These results suggest that compounds possessing polymethylene spacer between pharmacophore and lipophilic tail exhibit predominantly PPARalpha agonism whereas those with an aromatic phenylene spacer shows PPARalpha/gamma dual agonism.	polymethylene	48-61	peroxisome proliferator activated receptor alpha	Homo sapiens	133-142
14740174-5	2004	Previously, a potent T-cell response to a MHC class-II epitope was engineered by coupling the N-terminus of the pigeon cytochrome C [PGCC(95-104)] MHC class-II epitope to the C-terminus of an immunoregulatory segment of the Ii protein (hIi77-81, the Ii-Key peptide) through a polymethylene spacer.	polymethylene	276-289	cytochrome c, somatic	Homo sapiens	119-131
16000953-1	2005	Linking the Ii-Key functional group LRMK, through a simple polymethylene linker, to the melanoma gp100(48-58) MHC class II epitope significantly enhances the vaccine response to that epitope in DR4-IE transgenic mice.	polymethylene	59-72	premelanosome protein	Mus musculus	97-102
15755623-1	2005	Linkage of the Ii-Key segment of the Ii protein to MHC class II epitope gp100(46-58) using a polymethylene linker significantly enhances the production of epitope-specific antibodies in HLA-DR4-IE transgenic mice.	polymethylene	93-106	premelanosome protein	Mus musculus	72-77
14505892-2	2003	Hybrid peptides linking an immunoregulatory segment of the Ii protein (Ii-Key peptide) through a polymethylene bridge to MHC class II epitopes of HIV gp160 or gag are potent vaccines to elicit CD4(+) T cell responses.	polymethylene	97-110	leucyl/cystinyl aminopeptidase	Mus musculus	150-155