PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
12460746-0	2002	Desnitro-imidacloprid activates the extracellular signal-regulated kinase cascade via the nicotinic receptor and intracellular calcium mobilization in N1E-115 cells.	desnitroimidacloprid	0-21	mitogen-activated protein kinase 1	Mus musculus	36-73
12460746-2	2002	The excellent safety profile of IMI is not shared with a metabolite, desnitro-IMI (DNIMI), which displays high toxicity to mammals associated with agonist action at the alpha4beta2 nicotinic acetylcholine receptor (nAChR) in brain.	desnitroimidacloprid	69-81	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	215-220
12460746-2	2002	The excellent safety profile of IMI is not shared with a metabolite, desnitro-IMI (DNIMI), which displays high toxicity to mammals associated with agonist action at the alpha4beta2 nicotinic acetylcholine receptor (nAChR) in brain.	desnitroimidacloprid	83-88	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	215-220
12460746-3	2002	This study examines the hypothesis that IMI, DNIMI, and (-)-nicotine activate the extracellular signal-regulated kinase (ERK) cascade via primary interaction with the alpha4beta2 nAChR in mouse neuroblastoma N1E-115 cells.	desnitroimidacloprid	45-50	mitogen-activated protein kinase 1	Mus musculus	82-119
12460746-3	2002	This study examines the hypothesis that IMI, DNIMI, and (-)-nicotine activate the extracellular signal-regulated kinase (ERK) cascade via primary interaction with the alpha4beta2 nAChR in mouse neuroblastoma N1E-115 cells.	desnitroimidacloprid	45-50	mitogen-activated protein kinase 1	Mus musculus	121-124
12460746-3	2002	This study examines the hypothesis that IMI, DNIMI, and (-)-nicotine activate the extracellular signal-regulated kinase (ERK) cascade via primary interaction with the alpha4beta2 nAChR in mouse neuroblastoma N1E-115 cells.	desnitroimidacloprid	45-50	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	179-184
12460746-5	2002	DNIMI (1 microM)-induced ERK activation is blocked by nicotinic antagonist mecamylamine but not by alpha-bungarotoxin and muscarinic antagonist atropine.	desnitroimidacloprid	0-5	mitogen-activated protein kinase 1	Mus musculus	25-28
12460746-7	2002	2-Aminoethoxy-diphenylborate, a blocker for inositol 1,4,5-trisphosphate (IP(3))-mediated Ca(2+) release from intracellular stores, inhibits DNIMI-induced ERK activation but a high level of ryanodine (to block ryanodine receptor-mediated Ca(2+) release) does not.	desnitroimidacloprid	141-146	mitogen-activated protein kinase 1	Mus musculus	155-158
12460746-8	2002	The inhibitor U-73122 for phospholipase C (to suppress IP(3) production) prevents ERK activation evoked by DNIMI.	desnitroimidacloprid	107-112	mitogen-activated protein kinase 1	Mus musculus	82-85
23462233-8	2013	The other IMI nitroreduction metabolite, desnitro-IMI, was decreased by 55%, 65%, and 81% with tungsten, hydralazine, and in the AOX-deficient mice, respectively.	desnitroimidacloprid	41-53	acyl-Coenzyme A oxidase 1, palmitoyl	Mus musculus	129-132