PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29385661-0	2018	Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression.	conessine	0-9	tripartite motif-containing 63	Mus musculus	79-84
18683917-0	2008	The alkaloid conessine and analogues as potent histamine H3 receptor antagonists.	conessine	13-22	histamine receptor H3	Homo sapiens	47-68
18683917-2	2008	Conessine displayed high affinity at both rat and human H3 receptors (pKi = 7.61 and 8.27) and generally high selectivity against other sites, including histamine receptors H1, H2, and H4.	conessine	0-9	histamine receptor H1	Homo sapiens	153-187
18194865-1	2008	A new family of Histamine H(3) receptor antagonists (5a-t) has been prepared based on the structure of the natural product Conessine, a known H(3) antagonist.	conessine	123-132	histamine receptor H3	Homo sapiens	16-39
32387137-3	2020	Pretreatment of mice with the histamine H3 receptor antagonists JNJ-10181457 (5 and 10 mg/kg) or conessine (20 mg/kg), also showed similar inhibitory effects on METH-induced hyperlocomotion, similar to pitolisant.	conessine	97-106	histamine receptor H3	Mus musculus	30-51
29724080-0	2018	Conessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression.	conessine	0-9	tripartite motif-containing 63	Mus musculus	79-84
29724080-0	2018	Conessine Treatment Reduces Dexamethasone-Induced Muscle Atrophy by Regulating MuRF1 and Atrogin-1 Expression.	conessine	0-9	F-box protein 32	Mus musculus	89-98
29724080-4	2018	Here, we report that conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1.	conessine	21-30	tripartite motif-containing 63	Mus musculus	126-132
29724080-4	2018	Here, we report that conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1.	conessine	21-30	F-box protein 32	Mus musculus	137-146
29724080-5	2018	Promoter reporter assay revealed that conessine treatment inhibits FoxO3a-dependent transcription, NF-kappaB-dependent transcription, and p53-dependent transcription.	conessine	38-47	forkhead box O3	Mus musculus	67-73
29724080-5	2018	Promoter reporter assay revealed that conessine treatment inhibits FoxO3a-dependent transcription, NF-kappaB-dependent transcription, and p53-dependent transcription.	conessine	38-47	transformation related protein 53, pseudogene	Mus musculus	138-141
29724080-6	2018	We also showed by quantitative RT-PCR and western blot assays that conessine treatment reduced dexamethasone-induced expression of MuRF1 and atrogin-1.	conessine	67-76	tripartite motif-containing 63	Mus musculus	131-136
29724080-6	2018	We also showed by quantitative RT-PCR and western blot assays that conessine treatment reduced dexamethasone-induced expression of MuRF1 and atrogin-1.	conessine	67-76	F-box protein 32	Mus musculus	141-150
29385661-0	2018	Conessine treatment reduces dexamethasone-induced muscle atrophy by regulating MuRF1 and atrogin-1 expression.	conessine	0-9	F-box protein 32	Mus musculus	89-98
29385661-4	2018	Here, we report that conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1.	conessine	21-30	tripartite motif-containing 63	Mus musculus	126-132
29385661-4	2018	Here, we report that conessine reduces muscle atrophy by interfering with the expression of atrophy-related ubiquitin ligases MuRF-1 and atrogin-1.	conessine	21-30	F-box protein 32	Mus musculus	137-146
29385661-5	2018	Promoter reporter assay revealed that conessine treatment inhibits FoxO3a-dependent transcription, NF-kappaB-dependent transcription and p53-dependent transcription.	conessine	38-47	forkhead box O3	Mus musculus	67-73
29385661-5	2018	Promoter reporter assay revealed that conessine treatment inhibits FoxO3a-dependent transcription, NF-kappaB-dependent transcription and p53-dependent transcription.	conessine	38-47	transformation related protein 53, pseudogene	Mus musculus	137-140
29385661-6	2018	We also showed that conessine treatment reduced dexamethasone-induced expression of MuRF1 and atrogin-1 by the quantitative RT-PCR and Western blot.	conessine	20-29	tripartite motif-containing 63	Mus musculus	84-89
29385661-6	2018	We also showed that conessine treatment reduced dexamethasone-induced expression of MuRF1 and atrogin-1 by the quantitative RT-PCR and Western blot.	conessine	20-29	F-box protein 32	Mus musculus	94-103
27257813-1	2016	Conessine, a steroidal alkaloid isolated from Holarrhena floribunda, has anti-malarial activity and interacts with the histamine H3 receptor.	conessine	0-9	histamine receptor H3	Mus musculus	119-140