PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 12552245-5 2003 The experimental subjects were divided into two subgroups, based on the blood level of intact PTH (iPTH). ipth 99-103 parathyroid hormone Homo sapiens 94-97 14763069-11 2003 Interestingly, patients with low iPTH (< 100 pg/microL) showed relative EPO resistance, and patients with high iPTH (> 600 pg/microL) required smaller EPO doses. ipth 33-37 erythropoietin Homo sapiens 75-78 1425424-1 1992 The plasma concentration of immunoreactive PTH (iPTH) increases with postmaturational aging in both humans and animals. ipth 48-52 parathyroid hormone Homo sapiens 43-46 15775259-1 2002 Most commercial intact PTH (iPTH) assays cross-react with PTH7-84 and the proportional levels of PTH7-84 in patients are variable in a much wider range in samples obtained from hyperparathyroid patients. ipth 28-32 parathyroid hormone Homo sapiens 23-26 11084846-10 2000 It is therefore necessary to exclude the presence of hyperparathyroidism with ionised calcium and, in cases of high values, intact PTH (iPTH), before performing a histological diagnosis of a large cell bone tumor. ipth 136-140 parathyroid hormone Homo sapiens 131-134 10087252-3 1999 The present work was undertaken to study the changes of serum immunoreactive parathyroid hormone (iPTH) and calcitriol in pregnant rats with CRF. ipth 98-102 parathyroid hormone Rattus norvegicus 77-96 10087252-5 1999 The 5/6 nephrectomy (CRF1) resulted in renal failure with very high serum iPTH (100+/-18 pg/ml) and low calcitriol levels (10.6+/-4.3 pg/ml) compared with normal rats [N1: 14+/-2.5 pg/ml (P<0.001) and 18.2+/-4.2 pg/ml (P<0.01) respectively]. ipth 74-78 corticotropin releasing hormone receptor 1 Rattus norvegicus 21-25 10087252-6 1999 The pregnancy in CRF rats (CRF2) resulted in normalization of serum iPTH levels (18.2+/-5.41 pg/ml), which was associated with a parallel increase in serum calcitriol (29.4+/-8.0 pg/ml) similar to that in pregnancy of normal rats (N2). ipth 68-72 corticotropin releasing hormone receptor 2 Rattus norvegicus 27-31 9173368-2 1996 Parallel with the depression of iPTH levels it was enough a lower doses of recombinant human erythropoietin (Rh-EPO) to maintain the target hematocrit, while on two patients non-treated with Rh-EPO they founded an improvement in moderate anemia. ipth 32-36 erythropoietin Homo sapiens 93-107 8345045-1 1993 Calcium infusion in normal men decreases immunoreactive PTH (iPTH). ipth 61-65 parathyroid hormone Homo sapiens 56-59 12131092-3 2002 Recently the authors have found that most commercial intact PTH (iPTH) assays cross-react with non-(1-84) PTH (likely 7-84 PTH) and that the proportional levels of non-(1-84) PTH in patients were variable in a much wider range, accounting mostly for 20% to 60% of the immunoreactivity in samples obtained from hyperparathyroid patients. ipth 65-69 parathyroid hormone Homo sapiens 60-63 9612524-1 1998 BACKGROUND: Others have reported a clear distinction between patients with primary hyperparathyroidism (PHPT) and normal subjects using the intact PTH (iPTH) assay. ipth 152-156 parathyroid hormone Homo sapiens 147-150 8154313-7 1994 Serum immunoreactive PTH (iPTH) rose to twice pretreatment values (86 +/- 11 pM, mean +/- SEM; reference range for iPTH, > 50 years, < 50 pM; < 50 years, < 40 pM), returning to normal 4-8 weeks after therapy. ipth 26-30 parathyroid hormone Homo sapiens 21-24 8408450-8 1993 Serum osteocalcin increased by 35.7 +/- 17.3% (P < 0.05), serum immunoreactive PTH (iPTH) increased by 41.4 +/- 15.1% (P < 0.05), serum calcium decreased by 2.3 +/- 1.0% (P < 0.05), and serum albumin decreased by 4.5 +/- 1.7% (P < 0.05). ipth 87-91 parathyroid hormone Homo sapiens 82-85 1865080-5 1991 PTH levels should be helpful in defining coexisting hyperparathyroidism in patients with thyrotoxicosis since in the latter iPTH is usually suppressed. ipth 124-128 parathyroid hormone Homo sapiens 0-3 22398419-6 2012 iPTH levels after treatment correlated with age (r = -0.51, P = 0.031), mean cinacalcet dose (r = 0.65, P = 0.004), as well as baseline calcium (r = 0.65 P = 0.003), iPTH (r = 0.59, P = 0.01), E-selectin (r = 0.56, P = 0.016), and leptin (r = -0.49, P = 0.039). ipth 0-4 selectin E Homo sapiens 195-205 2335575-1 1990 In an earlier 8-day study, we showed increased immunoreactive PTH (iPTH) levels in young adults fed high phosphorus (P), low calcium (Ca) diets assembled from common grocery foods, a dietary pattern characteristic of teens and young adults. ipth 67-71 parathyroid hormone Homo sapiens 62-65 3760186-6 1986 Despite a moderate increase in ionized calcium, immunoreactive PTH (iPTH) increased from 64 +/- 7.7 to 118 +/- 21 pg/ml. ipth 68-72 parathyroid hormone Canis lupus familiaris 63-66 1986021-2 1991 The immunoreactive PTH (iPTH) level determined by RIA using antiserum specific for the C-terminal region of PTH-(65-69) was in the upper normal range (0.6 ng/mL) and over the next 7 yr increased gradually to 6 ng/mL. ipth 24-28 parathyroid hormone Homo sapiens 19-22 2017266-9 1991 We conclude that I-PTH assay has been shown to capture acute changes in parathyroid gland activity in hemodialyzed patients for both low and high iPTH levels. ipth 146-150 parathyroid hormone Homo sapiens 19-22 34595186-13 2021 Prospective studies are warranted to explore further model applications, such as patient-level prediction of iPTH response to PTH-lowering treatment. ipth 109-113 parathyroid hormone Homo sapiens 126-129 3496351-4 1987 Serum immunoreactive PTH (iPTH) levels were significantly higher during pregnancy than in nonpregnant women [97 +/- 5 vs. 56 +/- 4 ng/L (mean +/- SE); P less than 0.001]. ipth 26-30 parathyroid hormone Homo sapiens 21-24 34458210-8 2021 Moreover, serum iPTH was negatively correlated to LTI HA z-score (rs = -0.486, p = 0.006), and positively correlated to serum leptin levels (rs = 0.369, p = 0.041). ipth 16-20 leptin Homo sapiens 126-132 35055125-3 2022 We hypothesized that maintaining enough functional PTH1R/LRP6 coreceptor complexes at the plasma membrane through NACA-dependent Lrp6 transcription is important to ensure maximal response to iPTH. ipth 191-195 parathyroid hormone 1 receptor Mus musculus 51-56 35055125-3 2022 We hypothesized that maintaining enough functional PTH1R/LRP6 coreceptor complexes at the plasma membrane through NACA-dependent Lrp6 transcription is important to ensure maximal response to iPTH. ipth 191-195 low density lipoprotein receptor-related protein 6 Mus musculus 57-61 35055125-3 2022 We hypothesized that maintaining enough functional PTH1R/LRP6 coreceptor complexes at the plasma membrane through NACA-dependent Lrp6 transcription is important to ensure maximal response to iPTH. ipth 191-195 nascent polypeptide-associated complex alpha polypeptide Mus musculus 114-118 35055125-3 2022 We hypothesized that maintaining enough functional PTH1R/LRP6 coreceptor complexes at the plasma membrane through NACA-dependent Lrp6 transcription is important to ensure maximal response to iPTH. ipth 191-195 low density lipoprotein receptor-related protein 6 Mus musculus 129-133 35055125-8 2022 The iPTH treatment increased Alpl and Col1a1 mRNA levels in the control but not in the test group. ipth 4-8 alkaline phosphatase, liver/bone/kidney Mus musculus 29-33 35055125-8 2022 The iPTH treatment increased Alpl and Col1a1 mRNA levels in the control but not in the test group. ipth 4-8 collagen, type I, alpha 1 Mus musculus 38-44 35055125-9 2022 These results confirm that NACA and LRP6 form part of a common genetic pathway that is necessary for the full anabolic effect of iPTH. ipth 129-133 nascent polypeptide-associated complex alpha polypeptide Mus musculus 27-31 35055125-9 2022 These results confirm that NACA and LRP6 form part of a common genetic pathway that is necessary for the full anabolic effect of iPTH. ipth 129-133 low density lipoprotein receptor-related protein 6 Mus musculus 36-40 2918050-1 1989 In 41 hemodialysis patients with bone disease (histological diagnosis with histomorphometric confirmation of PTH activity) results from a serum immunoreactive PTH (iPTH) assay correlated with results from a new serum bioactive PTH (bio-PTH) assay (r = 0.84; P less than 0.001). ipth 164-168 parathyroid hormone Homo sapiens 159-162 2918050-1 1989 In 41 hemodialysis patients with bone disease (histological diagnosis with histomorphometric confirmation of PTH activity) results from a serum immunoreactive PTH (iPTH) assay correlated with results from a new serum bioactive PTH (bio-PTH) assay (r = 0.84; P less than 0.001). ipth 164-168 parathyroid hormone Homo sapiens 159-162 2918050-1 1989 In 41 hemodialysis patients with bone disease (histological diagnosis with histomorphometric confirmation of PTH activity) results from a serum immunoreactive PTH (iPTH) assay correlated with results from a new serum bioactive PTH (bio-PTH) assay (r = 0.84; P less than 0.001). ipth 164-168 parathyroid hormone Homo sapiens 159-162 3377074-4 1988 The livers cleared intact PTH and NH2-terminal immunoreactive PTH (iPTH) at the same rate. ipth 67-71 parathyroid hormone Rattus norvegicus 62-65 2821053-2 1987 Serum immunoreactive PTH (iPTH) was measured with two well characterized antisera; an amino (N)-terminal antiserum which cross-reacts with the biologically active domain (1-34) and recognizes intact hormone, and a midregion (44-68) antiserum which cross-reacts with intact hormone and biologically inactive midregion/C-terminal fragments. ipth 26-30 parathyroid hormone Homo sapiens 21-24 3944539-3 1986 Bioactive PTH correlated positively with immunoreactive PTH (iPTH) measured with a radioimmunoassay predominantly recognizing the middle- and carboxyl-terminal region of the PTH molecule (r = 0.503, P less than 0.001). ipth 61-65 parathyroid hormone Homo sapiens 10-13 2993339-1 1985 Previous studies suggested that estrogen administration leads to an increase in circulating immunoreactive PTH (iPTH), thought to be secondary to a slight decrease in serum calcium resulting from inhibition of bone resorption. ipth 112-116 parathyroid hormone Homo sapiens 107-110 3595732-3 1987 With the C-RIA 12 patients including the 2 patients not discriminated by the M-RIA had immunoreactive PTH (iPTH) values within the normal range of this assay (normal range: undetectable to 88.6 pmol/l). ipth 107-111 parathyroid hormone Homo sapiens 102-105 3595732-7 1987 Hyperparathyroid sera not discriminated by the C-RIA but with elevated iPTH in the M-RIA showed decreased amounts of midregion-C-terminal PTH fragments, while intact PTH comprised the highest amount of total circulating PTH immunoreactivity in the M-RIA. ipth 71-75 parathyroid hormone Homo sapiens 138-141 3595732-7 1987 Hyperparathyroid sera not discriminated by the C-RIA but with elevated iPTH in the M-RIA showed decreased amounts of midregion-C-terminal PTH fragments, while intact PTH comprised the highest amount of total circulating PTH immunoreactivity in the M-RIA. ipth 71-75 parathyroid hormone Homo sapiens 138-141 3787459-1 1986 The clinical value of measuring serum immunoreactive parathyroid hormone (iPTH) for the diagnosis of primary hyperparathyroidism is sometimes debated, and the clinical significance of an elevated postoperative serum iPTH level is unknown. ipth 74-78 parathyroid hormone Homo sapiens 53-72 3840668-8 1985 Serum calcium remained in the range 11-12 mg/100 ml in both diet groups, and serum immunoreactive PTH (iPTH) was modestly increased one- to twofold in the restricted group compared to the control group. ipth 103-107 parathyroid hormone Rattus norvegicus 98-101 3944539-3 1986 Bioactive PTH correlated positively with immunoreactive PTH (iPTH) measured with a radioimmunoassay predominantly recognizing the middle- and carboxyl-terminal region of the PTH molecule (r = 0.503, P less than 0.001). ipth 61-65 parathyroid hormone Homo sapiens 56-59 3944539-3 1986 Bioactive PTH correlated positively with immunoreactive PTH (iPTH) measured with a radioimmunoassay predominantly recognizing the middle- and carboxyl-terminal region of the PTH molecule (r = 0.503, P less than 0.001). ipth 61-65 parathyroid hormone Homo sapiens 56-59 6141381-8 1984 It is postulated that with increasing age 1,25-dihydroxyvitamin D levels fall, causing a rise in iPTH and thus in bone turnover, which is reflected by a rise in BGP levels. ipth 97-101 bone gamma-carboxyglutamate protein Homo sapiens 161-164 3972336-1 1985 In order to shed light on the discrepant changes in plasma immunoreactive parathyroid hormone (iPTH) during hemodialysis (HD) and ultrafiltration (UF) in end-stage renal failure, the influence of filtration of PTH fragments on the iPTH level in plasma was examined in 2 sets of experiments: in vitro dialysis of 125I-bPTH 1-84, 125I-hPTH 1-34 and 125I-hPTH 53-84 added to plasma was successively performed through a cuprophane membrane. ipth 95-99 parathyroid hormone Homo sapiens 74-93 6319444-2 1984 Serum immunoreactive PTH (iPTH) was measured with a goat antiserum developed against human PTH, using (43Tyr) human PTH-(44-68) as tracer and standards. ipth 26-30 parathyroid hormone Homo sapiens 21-24 7438468-5 1980 Mean plasma immunoreactive PTH (iPTH) levels increased significantly (P < 0.05) from 521 +/- 41 before to 696 +/- 96 ng/l after oestrogen treatment. ipth 32-36 parathyroid hormone Homo sapiens 27-30 6723731-4 1984 The major part of immunoreactive PTH (iPTH; on the average above 50%) eluted corresponding to fragments with a molecular size about 7,500 daltons in both radioimmunoassays. ipth 38-42 parathyroid hormone Homo sapiens 33-36 6312249-2 1983 In the studies reported here, we examined the effects of low extracellular calcium concentrations on basal and agonist-stimulated immunoreactive PTH (iPTH) release in dispersed bovine parathyroid cells. ipth 150-154 parathyroid hormone Bos taurus 145-148 6867614-1 1983 Serum immunoreactive PTH (iPTH) was measured in 74 patients with urolithiasis and correlated to the corresponding serum calcium values. ipth 26-30 parathyroid hormone Homo sapiens 21-24 7462403-1 1981 Immunostaining with antiserum to bovine parathyroid hormone (PTH) was used to delineate the immunoreactive PTH (iPTH)-containing cells of parathyroid glands from 1 anencephalic and 29 normal human fetuses. ipth 112-116 parathyroid hormone Bos taurus 40-59 7462403-1 1981 Immunostaining with antiserum to bovine parathyroid hormone (PTH) was used to delineate the immunoreactive PTH (iPTH)-containing cells of parathyroid glands from 1 anencephalic and 29 normal human fetuses. ipth 112-116 parathyroid hormone Bos taurus 61-64 7462403-1 1981 Immunostaining with antiserum to bovine parathyroid hormone (PTH) was used to delineate the immunoreactive PTH (iPTH)-containing cells of parathyroid glands from 1 anencephalic and 29 normal human fetuses. ipth 112-116 parathyroid hormone Bos taurus 107-110 7451639-2 1981 In vitro, histamine (10(-5)-10(-7) M) caused a dose-related significant stimulation of immunoreactive PTH (iPTH) secretion; this was blocked by the simultaneous addition of cimetidine (10(-5) M). ipth 107-111 parathyroid hormone Homo sapiens 102-105 6658372-4 1983 The molecular forms of serum iPTH were examined after gel filtration of Sephadex G-75 followed by Bio-Gel P-60 in nine patients. ipth 29-33 interferon induced protein with tetratricopeptide repeats 3 Homo sapiens 106-110 6822652-1 1983 Purified secretin infused in an estimated physiological dose caused an increase in serum immunoreactive PTH (iPTH) and calcitonin (iCT) in man. ipth 109-113 secretin Homo sapiens 9-17 6822652-1 1983 Purified secretin infused in an estimated physiological dose caused an increase in serum immunoreactive PTH (iPTH) and calcitonin (iCT) in man. ipth 109-113 parathyroid hormone Homo sapiens 104-107 6822652-2 1983 Ingestion of a gastric acid-stimulating test meal, a procedure known to increase endogenous secretin, caused increases in serum iPTH and plasma iCT in normal subjects. ipth 128-132 secretin Homo sapiens 92-100 7179613-3 1982 The carboxyl-terminal immunoreactive PTH (iPTH) values in these patients were 16 +/- 5 ngeq/ml (M +/- SD), no higher than the iPTH values in the other groups, e.g. normocalciuric patients had an iPTH of 23 +/- 8 ngeq/ml. ipth 42-46 parathyroid hormone Homo sapiens 37-40 7179613-3 1982 The carboxyl-terminal immunoreactive PTH (iPTH) values in these patients were 16 +/- 5 ngeq/ml (M +/- SD), no higher than the iPTH values in the other groups, e.g. normocalciuric patients had an iPTH of 23 +/- 8 ngeq/ml. ipth 42-46 MSD Homo sapiens 96-104 737558-3 1978 There was also a significant correlation of Fa47Ca with the serum phosphate (SeP) level and of immunoreactive parathyroid hormone (iPTH) with renal function. ipth 131-135 parathyroid hormone Homo sapiens 110-129 221182-3 1979 Eluates of gel slices were assayed for immunoreactive PTH (iPTH) in carboxy- and amino-terminal RIAs. ipth 59-63 parathyroid hormone Rattus norvegicus 54-57 182417-11 1976 The rapidity with which serum IPTH rose in response to magnesium therapy indicates that this may reflect a defect in parathyroid hormone (PTH) secretion rather than its biosynthesis. ipth 30-34 parathyroid hormone Homo sapiens 117-136 950371-2 1976 Patients with MEN 2a may be normocalcemic, with normal basal serum immunoreactive parathyroid hormone (iPTH) levels, yet have parathyroid hyperplasia discovered during thyroid surgery. ipth 103-107 ret proto-oncogene Homo sapiens 14-20 950371-10 1976 Calcium infusion combined with the measurement of serum iPTH levels may detect occult parathyroid hyperplasia in patients with MEN 2a, normocalcemia, and normal basal iPTH values. ipth 56-60 ret proto-oncogene Homo sapiens 127-133 1133897-4 1975 Infusion of a calcium-free Ringer"s solution into dogs was associated with increased urinary phosphateexcretion and serum immunoreactive parathyroid hormone concentration (iPTH), the latter being significantly correlated with a decrease in plasma ionized calcium concentration. ipth 172-176 parathyroid hormone Canis lupus familiaris 137-156 4338118-6 1972 Serum immunoreactive parathyroid hormone (IPTH) increased significantly after estrogen therapy; the change in IPTH was inversely related to the change in serum calcium (P < 0.001, sign test). ipth 42-46 parathyroid hormone Homo sapiens 21-40 11344563-4 1974 Infusion of salt-poor hyperoncotic albumin significantly decreased plasma ionized calcium, increased immunoreactive PTH (iPTH) in plasma, decreased sodium reabsorption by the proximal tubule, and increased phosphate clearance. ipth 121-125 albumin Canis lupus familiaris 35-42 4330004-3 1971 A second anti-PTH antiserum also differentiated between IPTH in the two groups, although IPTH was undetectable in only 1 of 14 sera. ipth 56-60 parathyroid hormone Homo sapiens 14-17 5543877-6 1971 Induced episodes of hypercalcemia and hypocalcemia resulted in appropriate responses in serum immunoreactive PTH (IPTH) in normal subjects and in patients with Paget"s disease of bone. ipth 114-118 parathyroid hormone Homo sapiens 109-112 31173642-4 2019 Mouse genetic lineage tracing revealed that iPTH treatment induced osteoblastic differentiation of bone marrow (BM) mesenchymal stem and progenitor cells (MSPCs), which carried the leptin receptor (LepR)-Cre. ipth 44-48 leptin receptor Mus musculus 181-196 32608117-9 2021 IGF-1 receptor inhibitor significantly restrained the anabolic effect of iPTH on OCCM-30 cells. ipth 73-77 insulin-like growth factor 1 receptor Rattus norvegicus 0-14 32608117-11 2021 IGF-1 is essential in mediating the anabolic effects of iPTH. ipth 56-60 insulin-like growth factor 1 Rattus norvegicus 0-5 31173642-9 2019 The expression levels of SP7/osterix (Osx) and Col1, which are markers for osteoblasts, were also increased in the LepR+ MSPCs population in response to iPTH treatment. ipth 153-157 leptin receptor Mus musculus 115-119 31173642-11 2019 Consistent with these results, iPTH treatment inhibited 5-fluorouracil- or ovariectomy (OVX)-induced LepR+ MSPC-derived adipogenesis in BM and increased LepR+ MSPC-derived osteoblasts, even under the adipocyte-induced conditions. ipth 31-35 leptin receptor Mus musculus 101-105 31173642-11 2019 Consistent with these results, iPTH treatment inhibited 5-fluorouracil- or ovariectomy (OVX)-induced LepR+ MSPC-derived adipogenesis in BM and increased LepR+ MSPC-derived osteoblasts, even under the adipocyte-induced conditions. ipth 31-35 leptin receptor Mus musculus 153-157 33420145-5 2021 iPTH was administered during 4 weeks before tooth extraction for Pre-PTH group and after tooth extraction for Post-PTH group. ipth 0-4 parathyroid hormone Rattus norvegicus 69-72 33049072-3 2021 The purpose of the current study wasto investigatewhether osteoprotegerin (OPG), an osteoclast inhibitor, enhances the known anabolic effects of mechanical loading (VEH)and intermittent PTH (iPTH) usinga well-established rabbit model of osseointegration.In the first set of experiments, OPG was administered either alone or combined with iPTH to study its effects on measured bone mass. ipth 191-195 tumor necrosis factor receptor superfamily member 11B Oryctolagus cuniculus 58-73 33049072-3 2021 The purpose of the current study wasto investigatewhether osteoprotegerin (OPG), an osteoclast inhibitor, enhances the known anabolic effects of mechanical loading (VEH)and intermittent PTH (iPTH) usinga well-established rabbit model of osseointegration.In the first set of experiments, OPG was administered either alone or combined with iPTH to study its effects on measured bone mass. ipth 191-195 tumor necrosis factor receptor superfamily member 11B Oryctolagus cuniculus 75-78 33049072-3 2021 The purpose of the current study wasto investigatewhether osteoprotegerin (OPG), an osteoclast inhibitor, enhances the known anabolic effects of mechanical loading (VEH)and intermittent PTH (iPTH) usinga well-established rabbit model of osseointegration.In the first set of experiments, OPG was administered either alone or combined with iPTH to study its effects on measured bone mass. ipth 191-195 parathyroid hormone Oryctolagus cuniculus 186-189 31173642-4 2019 Mouse genetic lineage tracing revealed that iPTH treatment induced osteoblastic differentiation of bone marrow (BM) mesenchymal stem and progenitor cells (MSPCs), which carried the leptin receptor (LepR)-Cre. ipth 44-48 leptin receptor Mus musculus 198-202 31173642-13 2019 These results indicated that iPTH treatment induced transient proliferation of the LepR+ MSPCs and skewed their lineage differentiation from adipocytes toward osteoblasts, resulting in an expanded, quiescent, and mature osteoblast population. ipth 29-33 leptin receptor Rattus norvegicus 83-87 31173642-6 2019 Here, we showed that LepR+ MSPCs differentiated into type I collagen (Col1)+ mature osteoblasts in response to iPTH treatment. ipth 111-115 leptin receptor Mus musculus 21-25 31173642-8 2019 However, the number of LepR-Cre-marked lineage cells in a proliferative state also increased in the vicinity of bone tissue after iPTH treatment. ipth 130-134 leptin receptor Mus musculus 23-27 31173642-9 2019 The expression levels of SP7/osterix (Osx) and Col1, which are markers for osteoblasts, were also increased in the LepR+ MSPCs population in response to iPTH treatment. ipth 153-157 Sp7 transcription factor Homo sapiens 25-36 31173642-9 2019 The expression levels of SP7/osterix (Osx) and Col1, which are markers for osteoblasts, were also increased in the LepR+ MSPCs population in response to iPTH treatment. ipth 153-157 Sp7 transcription factor Homo sapiens 38-41 30920026-1 2019 Intermittent parathyroid hormone (iPTH) is anti-osteoporotic and affects bone vessels. ipth 34-38 parathyroid hormone Mus musculus 13-32 30920026-7 2019 Additionally, we analyzed bone mRNA expression of 87 angiogenesis-related genes in mice treated with either intermittent or continuous PTH (iPTH/cPTH) or saline (CT) for 7, 14, and 28 days. ipth 140-144 parathyroid hormone Mus musculus 135-138 30920026-8 2019 iPTH dramatically decreased the percentage of THECs by 78% and 90% at days 7 and 14, respectively, and of LepR+ cells at day 14 (-46%) versus CT. Immunolabeling quantification showed that the intracortical Edm+ -vessel density increased at day 14 under iPTH. ipth 0-4 leptin receptor Mus musculus 106-110 30920026-11 2019 Finally, iPTH increased immunolabeling of endostatin, a Collagen-18 domain that can be cleaved and become antiangiogenic, in both endocortical (79%) and peritrabecular transitional microvessels at day 14. ipth 9-13 collagen, type XVIII, alpha 1 Mus musculus 42-52 26643857-5 2016 Moreover, iPTH-induced expression of receptor activator of NF-kappaB ligand (RANKL) and subsequent increased bone resorption are suppressed in those mice. ipth 10-14 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 77-82 30710837-12 2019 CONCLUSION: Both cPTH and iPTH promote midpalatal suture expansion by enhancing bone formation, probably via SOST downregulation and the resulting beta-catenin activation. ipth 26-30 sclerostin Rattus norvegicus 109-113 30710837-12 2019 CONCLUSION: Both cPTH and iPTH promote midpalatal suture expansion by enhancing bone formation, probably via SOST downregulation and the resulting beta-catenin activation. ipth 26-30 catenin beta 1 Rattus norvegicus 147-159 30038820-5 2018 Intermittent injection of PTH (iPTH) effectively attenuates disc degeneration of aged mice by direct signaling through NP cells, specifically improving intervertebral disc height and volume by increasing levels of TGF-beta activity, CCN2, and aggrecan. ipth 31-35 cellular communication network factor 2 Mus musculus 233-237 30038820-8 2018 Thus, mechanical stress-induced transport of PTH1R to the cilia enhances PTH signaling, which helps maintain intervertebral disc homeostasis, particularly during aging, indicating therapeutic potential of iPTH for DDD. ipth 205-209 parathyroid hormone 1 receptor Mus musculus 45-50 28894263-3 2017 Here, we report that serum intact-PTH (iPTH) and a genetic polymorphism in Pth are important for skin tumour resistance. ipth 39-43 parathyroid hormone Mus musculus 34-37 28243964-9 2017 In multivariate analysis, serum intact PTH (iPTH) was correlated with mean normal-to-normal R-R intervals, mean heart rate, and VLF, serum calcium was correlated with standard deviation of 5-min average of normal R-R intervals (SDANN), and serum phosphorus was correlated with VLF and LF/HF. ipth 44-48 parathyroid hormone Homo sapiens 39-42 27723935-7 2016 In vivo, intermittent PTH (iPTH)-induced suppression of sclerostin/SOST was accentuated in Dmp1-cre; Cdh2f/f (Cdh2DeltaDmp1 ) mice, compared with Cdh2f/f mice. ipth 27-31 sclerostin Mus musculus 56-66 27723935-7 2016 In vivo, intermittent PTH (iPTH)-induced suppression of sclerostin/SOST was accentuated in Dmp1-cre; Cdh2f/f (Cdh2DeltaDmp1 ) mice, compared with Cdh2f/f mice. ipth 27-31 sclerostin Mus musculus 67-71 27723935-7 2016 In vivo, intermittent PTH (iPTH)-induced suppression of sclerostin/SOST was accentuated in Dmp1-cre; Cdh2f/f (Cdh2DeltaDmp1 ) mice, compared with Cdh2f/f mice. ipth 27-31 dentin matrix protein 1 Mus musculus 91-95 27723935-7 2016 In vivo, intermittent PTH (iPTH)-induced suppression of sclerostin/SOST was accentuated in Dmp1-cre; Cdh2f/f (Cdh2DeltaDmp1 ) mice, compared with Cdh2f/f mice. ipth 27-31 dentin matrix protein 1 Mus musculus 110-123 27723935-8 2016 Additionally, iPTH had greater bone anabolic effects in Cdh2DeltaDmp1 mice compared to Cdh2f/f mice. ipth 14-18 dentin matrix protein 1 Mus musculus 56-69 27867867-0 2016 Early intact PTH (iPTH) is an early predictor of postoperative hypocalcemia for a safer and earlier hospital discharge: an analysis on 260 total thyroidectomies. ipth 18-22 parathyroid hormone Homo sapiens 13-16 27867867-3 2016 Early intact PTH (iPTH) has been proposed as early predictor of postoperative hypocalcemia. ipth 18-22 parathyroid hormone Homo sapiens 13-16 27192696-2 2016 OBJECTIVE: To assess: 1) the effects of D2 vs D3 on serum total and free 25D; and 2) whether change in intact PTH (iPTH) is more strongly associated with change in total vs free 25D. ipth 115-119 parathyroid hormone Homo sapiens 110-113 27438973-7 2016 RESULTS: Among controls, hypocalcemia elicited a major rise in intact PTH (iPTH) levels 4 minutes after bicarbonate infusion. ipth 75-79 parathyroid hormone Homo sapiens 70-73 26643857-1 2016 Intermittent parathyroid hormone administration (iPTH) increases bone mass and strength by stimulating osteoblast number and activity. ipth 49-53 parathyroid hormone Mus musculus 13-32 26643857-5 2016 Moreover, iPTH-induced expression of receptor activator of NF-kappaB ligand (RANKL) and subsequent increased bone resorption are suppressed in those mice. ipth 10-14 tumor necrosis factor (ligand) superfamily, member 11 Mus musculus 37-75 24483159-1 2014 OBJECTIVE: Our goal was to compare direct quantitation of circulating free 25-hydroxyvitamin D (25(OH)D)levels to calculated free 25(OH)D levels and their relationships to intact PTH (iPTH), a biomarker of 25(OH)D effect, in humans with a range of clinical conditions. ipth 184-188 parathyroid hormone Homo sapiens 179-182 25359628-6 2015 CD40L null mice exhibited a blunted increase in T cell production of Wnt10b and abrogated CD40 signaling in SCs in response to iPTH treatment. ipth 127-131 CD40 ligand Mus musculus 0-5 25359628-6 2015 CD40L null mice exhibited a blunted increase in T cell production of Wnt10b and abrogated CD40 signaling in SCs in response to iPTH treatment. ipth 127-131 CD40 antigen Mus musculus 0-4 26449567-10 2015 TN-C levels was significantly higher in both the high (&gt;300 pg/ml) and low iPTH groups (&lt;150 pg/ml) compared to the 150-300 pg/ml iPTH group (P&lt;.001, &lt;.001 respectively). ipth 82-86 tenascin C Homo sapiens 0-4 26449567-10 2015 TN-C levels was significantly higher in both the high (&gt;300 pg/ml) and low iPTH groups (&lt;150 pg/ml) compared to the 150-300 pg/ml iPTH group (P&lt;.001, &lt;.001 respectively). ipth 144-148 tenascin C Homo sapiens 0-4 26449567-11 2015 CONCLUSIONS: This study showed, for the first time in the literature, high levels of TN-C in the low and high iPTH groups and that this elevation was associated with iPTH. ipth 110-114 tenascin C Homo sapiens 85-89 26449567-11 2015 CONCLUSIONS: This study showed, for the first time in the literature, high levels of TN-C in the low and high iPTH groups and that this elevation was associated with iPTH. ipth 166-170 tenascin C Homo sapiens 85-89 26135074-4 2015 Using this model, we tested the hypothesis that intermittent injection of parathyroid hormone (iPTH) would increase proximal tibial cancellous osseointegration. ipth 95-99 parathyroid hormone Mus musculus 74-93 24937533-5 2014 We investigated their serum Mg levels and the correlation between intact PTH (iPTH) and the serum Mg levels and other clinical parameters and medications. ipth 78-82 parathyroid hormone Homo sapiens 73-76 24357520-4 2014 We report that combined treatment with Scl-Ab and iPTH was more potent than either iPTH or Scl-Ab alone in increasing stromal cell production of OPG, osteoblastogenesis, osteoblast life span, bone turnover, bone mineral density, and trabecular bone volume and structure in mice with T cells capable of producing Wnt10b. ipth 50-54 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 145-148 24395628-8 2014 There were statistically significant correlations between serum PAPP-A and bicarbonate, iPTH, and P in hemodialysis patients but not in control subjects. ipth 88-92 pappalysin 1 Homo sapiens 64-70 24357520-1 2014 Both blunted osteocytic production of the Wnt inhibitor sclerostin (Scl) and increased T-cell production of the Wnt ligand Wnt10b contribute to the bone anabolic activity of intermittent parathyroid hormone (iPTH) treatment. ipth 208-212 sclerostin Mus musculus 56-66 24357520-1 2014 Both blunted osteocytic production of the Wnt inhibitor sclerostin (Scl) and increased T-cell production of the Wnt ligand Wnt10b contribute to the bone anabolic activity of intermittent parathyroid hormone (iPTH) treatment. ipth 208-212 wingless-type MMTV integration site family, member 10B Mus musculus 112-115 24357520-1 2014 Both blunted osteocytic production of the Wnt inhibitor sclerostin (Scl) and increased T-cell production of the Wnt ligand Wnt10b contribute to the bone anabolic activity of intermittent parathyroid hormone (iPTH) treatment. ipth 208-212 wingless-type MMTV integration site family, member 10B Mus musculus 123-129 24357520-4 2014 We report that combined treatment with Scl-Ab and iPTH was more potent than either iPTH or Scl-Ab alone in increasing stromal cell production of OPG, osteoblastogenesis, osteoblast life span, bone turnover, bone mineral density, and trabecular bone volume and structure in mice with T cells capable of producing Wnt10b. ipth 50-54 wingless-type MMTV integration site family, member 10B Mus musculus 312-318 24357520-4 2014 We report that combined treatment with Scl-Ab and iPTH was more potent than either iPTH or Scl-Ab alone in increasing stromal cell production of OPG, osteoblastogenesis, osteoblast life span, bone turnover, bone mineral density, and trabecular bone volume and structure in mice with T cells capable of producing Wnt10b. ipth 83-87 tumor necrosis factor receptor superfamily, member 11b (osteoprotegerin) Mus musculus 145-148 22955916-3 2012 Silencing of PTH/PTH-related protein receptor (PPR) in T cells abrogates the effects of iPTH, thus demonstrating a requirement for direct PPR signaling in T cells. ipth 88-92 parathyroid hormone 1 receptor Mus musculus 47-50 23855914-7 2013 RESULTS: Individuals with MetSyn and heterozygosis for VDR 2228570 C > T have higher concentrations of iPTH and HOMA beta than those without this polymorphism, and subjects with recessive homozygosis for the same polymorphisms presented higher insulin resistance than those with the heterozygous genotype. ipth 106-110 vitamin D receptor Homo sapiens 55-58 23814412-5 2013 Compared to the controls, CKD subjects showed elevated intact PTH (iPTH), BAP, and tDPD and lower BMD. ipth 67-71 parathyroid hormone Homo sapiens 62-65 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 34-38 parathyroid hormone Homo sapiens 13-32 22497226-7 2012 For verification of the systemic effect of iPTH application, blood serum levels of osteocalcin were determined. ipth 43-47 bone gamma-carboxyglutamate protein Homo sapiens 83-94 22497226-11 2012 Blood serum levels of osteocalcin were elevated significantly with iPTH. ipth 67-71 bone gamma-carboxyglutamate protein Homo sapiens 22-33 22393015-3 2012 Here, we show that conditional silencing of PPR in T cells blunts the capacity of iPTH to induce T-cell production of Wnt10b; activate Wnt signaling in osteoblasts; expand the osteoblastic pool; and increase bone turnover, bone mineral density, and trabecular bone volume. ipth 82-86 Wnt family member 10B Homo sapiens 118-121 22700192-10 2012 By contrast, non-ovariectomised Ampkalpha1(-/-) mice responded better to iPTH treatment than non-ovariectomised Ampkalpha1(+)(/)(+) mice. ipth 73-77 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 32-42 22700192-11 2012 Overall, these data demonstrate that Ampkalpha1(-/-) mice are less affected by changes in bone turnover induced by OVX but respond better to the anabolic challenge induced by iPTH. ipth 175-179 protein kinase, AMP-activated, alpha 1 catalytic subunit Mus musculus 37-47 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 34-38 Wnt family member 10B Homo sapiens 97-100 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 34-38 Wnt family member 10B Homo sapiens 108-114 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 34-38 Wnt family member 10B Homo sapiens 108-111 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 138-142 parathyroid hormone Homo sapiens 13-32 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 138-142 Wnt family member 10B Homo sapiens 97-100 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 138-142 Wnt family member 10B Homo sapiens 108-114 22393015-1 2012 Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. ipth 138-142 Wnt family member 10B Homo sapiens 108-111 22393015-2 2012 However, it is unknown whether iPTH induces Wnt10b production and bone anabolism through direct activation of the parathyroid hormone (PTH)/PTH-related protein receptor (PPR) in T cells. ipth 31-35 parathyroid hormone Homo sapiens 114-133 22393015-2 2012 However, it is unknown whether iPTH induces Wnt10b production and bone anabolism through direct activation of the parathyroid hormone (PTH)/PTH-related protein receptor (PPR) in T cells. ipth 31-35 PPR1 Homo sapiens 170-173 22393015-3 2012 Here, we show that conditional silencing of PPR in T cells blunts the capacity of iPTH to induce T-cell production of Wnt10b; activate Wnt signaling in osteoblasts; expand the osteoblastic pool; and increase bone turnover, bone mineral density, and trabecular bone volume. ipth 82-86 PPR1 Homo sapiens 44-47 22393015-3 2012 Here, we show that conditional silencing of PPR in T cells blunts the capacity of iPTH to induce T-cell production of Wnt10b; activate Wnt signaling in osteoblasts; expand the osteoblastic pool; and increase bone turnover, bone mineral density, and trabecular bone volume. ipth 82-86 Wnt family member 10B Homo sapiens 118-124 17891053-1 2007 OBJECTIVES: To study the relationship of intraoperative intact parathyroid hormone levels (iPTH) with parathyroid adenoma weight and volume in patients with primary hyperparathyroidism. ipth 91-95 parathyroid hormone Homo sapiens 63-82 21652726-8 2011 Dual energy x-ray absorptiometry-derived measures of intermittent PTH (iPTH)-induced bone gain were impaired in Sost(-/-) mice. ipth 71-75 parathyroid hormone Mus musculus 66-69 21652726-8 2011 Dual energy x-ray absorptiometry-derived measures of intermittent PTH (iPTH)-induced bone gain were impaired in Sost(-/-) mice. ipth 71-75 sclerostin Mus musculus 112-116 19832854-10 2010 Dkk-1 change was positively correlated to Ca (r = 0.530, P = 0.004) and negatively correlated to iPTH change (r = -0.398, P = 0.040). ipth 97-101 dickkopf WNT signaling pathway inhibitor 1 Homo sapiens 0-5 18826856-5 2008 After adjusting for independent variables including age, diabetic status and plasma levels of C-reactive protein, phosphorus and albumin significant predictors of iPTH were race (p < 0.01), gender (p < 0.05), serum calcium (p < 0.05), BSAP (p < 0.0001) and doses of vitamin D analogs (p < 0.001). ipth 163-167 C-reactive protein Homo sapiens 94-112 18826856-5 2008 After adjusting for independent variables including age, diabetic status and plasma levels of C-reactive protein, phosphorus and albumin significant predictors of iPTH were race (p < 0.01), gender (p < 0.05), serum calcium (p < 0.05), BSAP (p < 0.0001) and doses of vitamin D analogs (p < 0.001). ipth 163-167 paired box 5 Homo sapiens 244-248 21427530-5 2012 RESULTS: An improvement of the typical clinical symptoms was found in every patient undergoing surgery, and a significant reduction in intact PTH (iPTH) serum levels was achieved. ipth 147-151 parathyroid hormone Homo sapiens 142-145 21652726-14 2011 iPTH-induced resorption of cortical bone might be overstimulated in Sost-deficient environments. ipth 0-4 sclerostin Mus musculus 68-72 20641075-12 2010 The rate of decrease in serum iPTH detected intraoperatively compared to preoperative baseline levels exceeding 90% in sPx, 95% in tPx, accurately predicts the success of surgery. ipth 30-34 spexin hormone Homo sapiens 119-122 20641075-12 2010 The rate of decrease in serum iPTH detected intraoperatively compared to preoperative baseline levels exceeding 90% in sPx, 95% in tPx, accurately predicts the success of surgery. ipth 30-34 thyroid peroxidase Homo sapiens 131-134 20089790-1 2010 The concentration or threshold of 25-hydroxyvitamin D [25(OH)D] needed to maximally suppress intact serum parathyroid hormone (iPTH) has been suggested as a measure of optimal vitamin D status. ipth 127-131 parathyroid hormone Homo sapiens 106-125 18520104-2 2008 The aim of this prospective trial was to evaluate the acute and chronic effects of TPTD in endogenous intact PTH (iPTH) levels in postmenopausal women with established osteoporosis. ipth 114-118 parathyroid hormone Homo sapiens 109-112 17243917-5 2007 The correlations between PAPP-A and iPTH, calcium, phosphorus and ALP were determined. ipth 36-40 pappalysin 1 Homo sapiens 25-31 16425080-3 2006 Here we evaluate the addition of a rapid intraoperative parathyroid hormone (iPTH) assay for patients undergoing MIRP. ipth 77-81 parathyroid hormone Homo sapiens 56-75 17002574-10 2006 In multiple stepwise linear regression analysis, levels of 25-hydroxyvitamin D correlated positively and intact PTH (iPTH) correlated negatively to Z scores at the lumbar spine and wrist. ipth 117-121 parathyroid hormone Homo sapiens 112-115 17243917-8 2007 There was a weak but statistically significant positive correlation between serum PAPP-A and iPTH (r=0.216; p=0.041) and ALP (r=0.205; p=0.044) in the hemodialysis group. ipth 93-97 pappalysin 1 Homo sapiens 82-88 16785355-7 2006 The algorithm for this group of patients specified that they should receive an injection with technetium Tc 99m sestamibi prior to parathyroidectomy and that an intraoperative parathyroid hormone (iPTH) level decrease of more than 50% be used to define intraoperative success. ipth 197-201 parathyroid hormone Homo sapiens 176-195 15909594-7 2005 The difference of the results of the two PTH assay methods, which indicated the portion of 7-84 PTH fragments of the total PTH molecules measured with the iPTH assay, was gradually increased while the severity of uremic hyperparathyroidism increased. ipth 155-159 parathyroid hormone Homo sapiens 41-44 15909594-7 2005 The difference of the results of the two PTH assay methods, which indicated the portion of 7-84 PTH fragments of the total PTH molecules measured with the iPTH assay, was gradually increased while the severity of uremic hyperparathyroidism increased. ipth 155-159 parathyroid hormone Homo sapiens 96-99 15909594-7 2005 The difference of the results of the two PTH assay methods, which indicated the portion of 7-84 PTH fragments of the total PTH molecules measured with the iPTH assay, was gradually increased while the severity of uremic hyperparathyroidism increased. ipth 155-159 parathyroid hormone Homo sapiens 96-99 16642663-10 2005 The positive correlation of high serum iPTH with inflammation implies further need to control hyperphosphatemia and secondary hyperparathyroidism in HD patients, also inverse correlation of serum CRP with cholesterol and triglyceride further support the malnutrition-inflammation complex syndrome (MICS) which frequently seen in hemodialysis patients (Tab. ipth 39-43 C-reactive protein Homo sapiens 196-199 15828900-10 2005 Serum intact PTH (iPTH) significantly increased in patients with a low or normal iPTH level (< or =300 pg/mL), while it did not change in patients with secondary hyperparathyroidism (>300 pg/mL). ipth 18-22 parathyroid hormone Homo sapiens 13-16 15828900-10 2005 Serum intact PTH (iPTH) significantly increased in patients with a low or normal iPTH level (< or =300 pg/mL), while it did not change in patients with secondary hyperparathyroidism (>300 pg/mL). ipth 81-85 parathyroid hormone Homo sapiens 13-16 15631341-3 2004 CIP was calculated by subtraction of CAP from iPTH. ipth 46-50 muscular LMNA interacting protein Homo sapiens 0-3 15631341-8 2004 In whole group of patients iPTH, CAP, CIP but not CAP/CIP correlated negatively with OPGL and OPGL/OPG as well as positively with dialysis duration, OPG and AP. ipth 27-31 TNF superfamily member 11 Homo sapiens 85-89 14507273-6 2003 RESULTS: Oral Ca induced dose-sensitive changes in parathyroid hormone (iPTH), total (tCa), and ionized (iCa) calcium levels. ipth 72-76 parathyroid hormone Homo sapiens 51-70