PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
14646616-5	2003	The effect of vitamin C treatment was blocked by the antioxidant N-acetyl-L-cysteine, suggesting that vitamin C affects IL-18 expression by up-regulating intracellular reactive oxygen intermediate (ROI) levels.	reactive oxygen	168-183	interleukin 18	Mus musculus	120-125
14572638-3	2003	In this report we provide evidence that alpha-MSH inhibited serum-activated lipopolysaccharide (SA-LPS)-induced proteolytic enzyme release, oxidative burst response, reactive oxygen intermediate generation, nitric oxide production, and adhesion molecule expression in monocyte-derived macrophages.	reactive oxygen	166-181	proopiomelanocortin	Homo sapiens	40-49
14578853-7	2003	Overexpression of Cu/Zn-SOD and Mn-SOD also partially protected E47 cells from the increase in reactive oxygen production and lipid peroxidation and the loss of mitochondrial membrane potential induced by AA and iron.	reactive oxygen	95-110	superoxide dismutase 2	Homo sapiens	32-38
14708622-0	2003	S100A8 induction in keratinocytes by ultraviolet A irradiation is dependent on reactive oxygen intermediates.	reactive oxygen	79-94	S100 calcium binding protein A8 (calgranulin A)	Mus musculus	0-6
14570769-5	2003	Although P450 2C9 substrate S-warfarin partially protected against inactivation, reactive oxygen scavengers such as superoxide dismutase and catalase did not prevent inactivation.	reactive oxygen	81-96	catalase	Homo sapiens	141-149
12957295-7	2003	Reactive oxygen production, lipid peroxidation, and interaction with iron chelates have been shown to be enhanced with microsomes isolated from ethanol-treated rats with elevated levels of CYP2E1.	reactive oxygen	0-15	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	189-195
12810543-0	2003	Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis.	reactive oxygen	0-15	steroidogenic acute regulatory protein	Mus musculus	79-109
12810543-0	2003	Reactive oxygen disrupts mitochondria in MA-10 tumor Leydig cells and inhibits steroidogenic acute regulatory (StAR) protein and steroidogenesis.	reactive oxygen	0-15	steroidogenic acute regulatory protein	Mus musculus	111-115
12784910-3	2003	Since, it has been found that exogenous growth hormone (GH) primes neutrophils for the production of reactive oxygen intermediates (ROI) and in particular superoxide (O2-), we investigated the role of GH on the production of O2- in T cells.	reactive oxygen	101-116	growth hormone	Mus musculus	40-54
12784910-3	2003	Since, it has been found that exogenous growth hormone (GH) primes neutrophils for the production of reactive oxygen intermediates (ROI) and in particular superoxide (O2-), we investigated the role of GH on the production of O2- in T cells.	reactive oxygen	101-116	growth hormone	Mus musculus	56-58
12431383-0	2002	Reactive oxygen intermediates in TNF signaling.	reactive oxygen	0-15	tumor necrosis factor	Homo sapiens	33-36
12707355-0	2003	Mitochondrial potential and reactive oxygen intermediates in antigen-specific CD8+ T cells during viral infection.	reactive oxygen	28-43	CD8a molecule	Homo sapiens	78-81
12727804-7	2003	Genes whose transcription was altered in common among all the treated keratinocytes included those induced by reactive oxygen, of which heme oxygenase-1 displayed the highest fold induction.	reactive oxygen	110-125	heme oxygenase 1	Homo sapiens	136-152
12723939-5	2003	These compounds also inhibited the production of NO and H2O2 induced by TNF-alpha, which suggests that the inhibition of ICAM-1 expression by the three compounds may be due to the modulated production of the reactive oxygen/nitrogen components.	reactive oxygen	208-223	tumor necrosis factor	Homo sapiens	72-81
12723939-5	2003	These compounds also inhibited the production of NO and H2O2 induced by TNF-alpha, which suggests that the inhibition of ICAM-1 expression by the three compounds may be due to the modulated production of the reactive oxygen/nitrogen components.	reactive oxygen	208-223	intercellular adhesion molecule 1	Homo sapiens	121-127
12456885-2	2002	Because mitochondrial respiration is the principal source of reactive oxygen within cells, the mitochondrially localized superoxide dismutase (SOD) 2 is thought to play an important front-line defensive role against aging-related oxidative stress.	reactive oxygen	61-76	Superoxide dismutase 2 (Mn)	Drosophila melanogaster	121-149
12485430-9	2002	These effects of substance P may be mediated via phospholipase C activation, intra-cellular Ca2+ signal, and reactive oxygen intermediates.	reactive oxygen	109-124	tachykinin precursor 1	Homo sapiens	17-28
12672017-12	2003	PDTC abolishes constitutive and neurotrophin-induced expression of iNOS mRNA and protein and abolishes constitutive expression of nNOS mRNA, suggesting that reactive oxygen intermediates promote expression of nNOS.	reactive oxygen	157-172	brain derived neurotrophic factor	Homo sapiens	32-44
12672017-12	2003	PDTC abolishes constitutive and neurotrophin-induced expression of iNOS mRNA and protein and abolishes constitutive expression of nNOS mRNA, suggesting that reactive oxygen intermediates promote expression of nNOS.	reactive oxygen	157-172	nitric oxide synthase 1	Homo sapiens	209-213
12650847-7	2003	We conclude that impairment of reactive oxygen intermediates production, through scavenging reactive oxygen intermediates by baicalin, or antagonizing ligand-initiated Ca(2+) influx by baicalein, accounts for the inhibition of Mac-1-dependent leukocyte adhesion that confers the anti-inflammatory activity of baicalin or baicalein.	reactive oxygen	31-46	integrin subunit alpha M	Homo sapiens	227-232
12682616-17	2003	Reactive oxygen intermediates can also function as signaling messengers to activate transcription factors, like NFkB and AP-1, and induce gene expression.	reactive oxygen	0-15	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	121-125
12552126-5	2003	Reactive oxygen intermediates were identified as candidate mediators of cardiomyopathic effects in MHC-PPAR mice.	reactive oxygen	0-15	peroxisome proliferator activated receptor alpha	Mus musculus	103-107
12431383-4	2002	It has also been suggested that TNF mediates its intracellular signaling by adjusting the redox potential of the cell, specifically through reactive oxygen intermediates (also known as reactive oxygen species).	reactive oxygen	140-155	tumor necrosis factor	Homo sapiens	32-35
12472690-4	2002	PLA2 activity was poorly induced in response to drought, wounding, reactive oxygen intermediates, salicylic acid (SA) or methyl-jasmonate (MJ) whereas the ethylene (ET) precursor, 1-aminocyclopropane-1-carboxylic acid (ACC), provoked a moderate induction.	reactive oxygen	67-82	phospholipase A2-alpha-like	Nicotiana tabacum	0-4
12387830-4	2002	The effect of UVB irradiation was blocked by antioxidant, N-acetyl-L-cysteine (NAC), which suggested the involvement of reactive oxygen intermediates (ROI) in the signal transduction of UVB irradiation-enhanced IL-18 synthesis.	reactive oxygen	120-135	X-linked Kx blood group	Homo sapiens	79-82
12398935-3	2002	In the present study we examined the dependence of mitochondrial reactive oxygen production on the aromatic hydrocarbon receptor (AHR), cytochrome P450 1A1 (CYP1A1), and cytochrome P450 1A2 (CYP1A2), proteins believed to be important in dioxin-induced liver toxicity.	reactive oxygen	65-80	aryl-hydrocarbon receptor	Mus musculus	130-133
12398935-3	2002	In the present study we examined the dependence of mitochondrial reactive oxygen production on the aromatic hydrocarbon receptor (AHR), cytochrome P450 1A1 (CYP1A1), and cytochrome P450 1A2 (CYP1A2), proteins believed to be important in dioxin-induced liver toxicity.	reactive oxygen	65-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	136-155
12398935-3	2002	In the present study we examined the dependence of mitochondrial reactive oxygen production on the aromatic hydrocarbon receptor (AHR), cytochrome P450 1A1 (CYP1A1), and cytochrome P450 1A2 (CYP1A2), proteins believed to be important in dioxin-induced liver toxicity.	reactive oxygen	65-80	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	157-163
12398935-3	2002	In the present study we examined the dependence of mitochondrial reactive oxygen production on the aromatic hydrocarbon receptor (AHR), cytochrome P450 1A1 (CYP1A1), and cytochrome P450 1A2 (CYP1A2), proteins believed to be important in dioxin-induced liver toxicity.	reactive oxygen	65-80	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	170-189
12213816-0	2002	Zinc release from protein kinase C as the common event during activation by lipid second messenger or reactive oxygen.	reactive oxygen	102-117	proline rich transmembrane protein 2	Homo sapiens	18-34
12387830-4	2002	The effect of UVB irradiation was blocked by antioxidant, N-acetyl-L-cysteine (NAC), which suggested the involvement of reactive oxygen intermediates (ROI) in the signal transduction of UVB irradiation-enhanced IL-18 synthesis.	reactive oxygen	120-135	interleukin 18	Homo sapiens	211-216
12780970-4	2002	Measurement: Cultured type II cells were subjected to xanthine oxidase-derived reactive oxygen stress at variable concentrations and incubation times.	reactive oxygen	79-94	xanthine dehydrogenase	Mus musculus	54-70
12385890-0	2002	Interaction between nitric oxide, reactive oxygen intermediates, and peroxynitrite in the regulation of 5-lipoxygenase metabolism.	reactive oxygen	34-49	arachidonate 5-lipoxygenase	Homo sapiens	104-118
12385890-2	2002	Here we examined the possibility that reactive oxygen intermediates (ROI) generated by LPS pretreatment contribute to the suppression of 5-lipoxygenase (5-LO) metabolism.	reactive oxygen	38-53	arachidonate 5-lipoxygenase	Homo sapiens	137-151
12097418-0	2002	Persistent mitochondrial hyperpolarization, increased reactive oxygen intermediate production, and cytoplasmic alkalinization characterize altered IL-10 signaling in patients with systemic lupus erythematosus.	reactive oxygen	54-69	interleukin 10	Homo sapiens	147-152
12070712-11	2002	GM-CSF/IL-2 therapy seems to induce an immune suppressive stage compared to GM-CSF alone affecting cytotoxic mononuclear cells and B cells, which might be mediated through the neopterin metabolic pathway or other inducible immune suppressive factors such as reactive oxygen and nitrogen intermediates.	reactive oxygen	258-273	colony stimulating factor 2	Homo sapiens	0-6
12070712-11	2002	GM-CSF/IL-2 therapy seems to induce an immune suppressive stage compared to GM-CSF alone affecting cytotoxic mononuclear cells and B cells, which might be mediated through the neopterin metabolic pathway or other inducible immune suppressive factors such as reactive oxygen and nitrogen intermediates.	reactive oxygen	258-273	interleukin 2	Homo sapiens	7-11
12090619-0	2002	Reactive oxygen intermediates and glutathione regulate the expression of cytosolic ascorbate peroxidase during iron-mediated oxidative stress in bean.	reactive oxygen	0-15	L-ascorbate peroxidase 2, cytosolic-like	Nicotiana tabacum	73-103
11973583-5	2002	ET-1 also prevented the inhibitive effect of reactive oxygen on microsomal CCT activity in the lung explants.	reactive oxygen	45-60	endothelin 1	Homo sapiens	0-4
11964604-1	2002	BACKGROUND: Cytokines such as tumor necrosis factor alpha (TNF-alpha) are produced by the myocardium in heart disease and might be stimulated by reactive oxygen.	reactive oxygen	145-160	tumor necrosis factor	Rattus norvegicus	30-57
11964604-1	2002	BACKGROUND: Cytokines such as tumor necrosis factor alpha (TNF-alpha) are produced by the myocardium in heart disease and might be stimulated by reactive oxygen.	reactive oxygen	145-160	tumor necrosis factor	Rattus norvegicus	59-68
12470500-0	2002	Reactive oxygen as modulator of TNF and fas receptor-mediated apoptosis in vivo: studies with glutathione peroxidase-deficient mice.	reactive oxygen	0-15	tumor necrosis factor	Mus musculus	32-35
12059104-2	2002	The recessive mutant designated cir1 exhibited constitutive expression of salicylic acid (SA), jasmonic acid (JA)/ethylene, and reactive oxygen intermediate-dependent genes.	reactive oxygen	128-143	Homeodomain-like superfamily protein	Arabidopsis thaliana	32-36
11805326-0	2002	Reactive oxygen generated by Nox1 triggers the angiogenic switch.	reactive oxygen	0-15	NADPH oxidase 1	Homo sapiens	29-33
11805326-1	2002	The reactive oxygen-generating enzyme Nox1 transforms NIH 3T3 cells, rendering them highly tumorigenic and, as shown herein, also increases tumorigenicity of DU-145 prostate epithelial cells.	reactive oxygen	4-19	NADPH oxidase 1	Mus musculus	38-42
11740866-1	2002	Reactive oxygen intermediates have been implicated in the transduction of TNFalpha signals, although the source of such oxidants has not been established.	reactive oxygen	0-15	tumor necrosis factor	Homo sapiens	74-82
12716289-0	2002	Reactive Oxygen and Nitrogen Oxide Species-induced Stress, a Major Intrinsic Factor Involved in Carcinogenic Processes and a Possible Target for Cancer Prevention.	reactive oxygen	0-15	cobalamin binding intrinsic factor	Homo sapiens	67-83
12716289-2	2002	For multistage carcinogenic processes, reactive oxygen and nitrogen oxide species-induced stress (RONOSS) serves as a major intrinsic factor and is involved in every step.	reactive oxygen	39-54	cobalamin binding intrinsic factor	Homo sapiens	124-140
11583958-0	2001	Reactive oxygen intermediates induce monocyte chemotactic protein-1 in vascular endothelium after brief ischemia.	reactive oxygen	0-15	C-C motif chemokine ligand 2	Canis lupus familiaris	37-67
11862946-4	2002	Two reactive oxygen generating compounds, paraquat and acifluorfen, were found to cause induction of both phytoalexin accumulation and PDF1.2 expression in wild-type plants, but this induction was almost completely abolished in esa1.	reactive oxygen	4-19	protodermal factor 1	Arabidopsis thaliana	135-139
11811521-1	2001	Reactive oxygen intermediates (ROIs), such as hydrogen peroxide (H2O2), have been implicated as second messengers in the activation of NF-kappaB by a variety of stimuli, including tumour necrosis factor-alpha (TNF-alpha).	reactive oxygen	0-15	nuclear factor kappa B subunit 1	Homo sapiens	135-144
11811521-1	2001	Reactive oxygen intermediates (ROIs), such as hydrogen peroxide (H2O2), have been implicated as second messengers in the activation of NF-kappaB by a variety of stimuli, including tumour necrosis factor-alpha (TNF-alpha).	reactive oxygen	0-15	tumor necrosis factor	Homo sapiens	210-219
11546669-1	2001	The role of platelet-activating factor (PAF) in Ca(2+) signaling and Ca(2+)-related enhancement of reactive oxygen intermediate (ROI) generation in neutrophils of burn-injured rats was ascertained by evaluating the effect of treatment of the rats with a PAF receptor antagonist.	reactive oxygen	99-114	PCNA clamp associated factor	Rattus norvegicus	12-38
11583958-8	2001	Pretreatment with the reactive oxygen scavenger N-(2-mercaptopropionyl)-glycine completely inhibited MCP-1 induction.	reactive oxygen	22-37	C-C motif chemokine ligand 2	Canis lupus familiaris	101-106
11583958-12	2001	In vitro, treatment of cultured canine jugular vein endothelial cells with the reactive oxygen intermediate H2O2 induced a concentration-dependent increase in MCP-1 mRNA levels, which was inhibited by the antioxidant N-acetyl-L-cysteine, a precursor of glutathione, but not pyrrolidine dithiocarbamate, an inhibitor of NF-kappaB and activator of AP-1.	reactive oxygen	79-94	C-C motif chemokine ligand 2	Canis lupus familiaris	159-164
11534964-9	2001	It has been demonstrated that reactive oxygen intermediates induce TGFbeta1 gene expression.	reactive oxygen	30-45	transforming growth factor, beta 1	Mus musculus	67-75
11577346-3	2001	Because of its variety of reaction partners (DNA, proteins, low-molecular weight thiols, prosthetic groups, reactive oxygen intermediates), its widespread production (by three different NO synthases (NOS) and the fact that its activity is strongly influenced by its concentration, NO continues to surprise and perplex immunologists.	reactive oxygen	108-123	nitric oxide synthase 2	Homo sapiens	186-198
11595797-7	2001	The roles of EDS1 and PAD4 in regulating lsd1 runaway cell death are related to the interpretation of reactive oxygen intermediate-derived signals at infection sites.	reactive oxygen	102-117	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	13-17
11595797-7	2001	The roles of EDS1 and PAD4 in regulating lsd1 runaway cell death are related to the interpretation of reactive oxygen intermediate-derived signals at infection sites.	reactive oxygen	102-117	alpha/beta-Hydrolases superfamily protein	Arabidopsis thaliana	22-26
11595797-7	2001	The roles of EDS1 and PAD4 in regulating lsd1 runaway cell death are related to the interpretation of reactive oxygen intermediate-derived signals at infection sites.	reactive oxygen	102-117	LSD1 zinc finger family protein	Arabidopsis thaliana	41-45
11453645-0	2001	Reactive oxygen and NF-kappaB in VEGF-induced migration of human vascular smooth muscle cells.	reactive oxygen	0-15	vascular endothelial growth factor A	Homo sapiens	33-37
11529937-1	2001	CR3 and Fc gamma Rs are the main receptors involved in the phagocytic process leading to engulfment and killing of microbes by production of reactive oxygen intermediates (ROI) and degranulation.	reactive oxygen	141-156	teratocarcinoma-derived growth factor 1 pseudogene 3	Homo sapiens	0-3
11554448-6	2001	Furthermore, we also review the available evidence on the role of p53 as a transactivator or transrepressor of genes involved in the production and control of reactive oxygen intermediates.	reactive oxygen	159-174	tumor protein p53	Homo sapiens	66-69
11160238-5	2001	Actual levels of reactive oxygen and nitrogen intermediates in the livers of infected IL-4(-/-) animals are thus likely to be considerably higher than those in the livers of infected WT mice.	reactive oxygen	17-32	interleukin 4	Mus musculus	86-90
11262191-8	2001	Since glutathione and thioredoxin can protect from drug-induced apoptosis, their upregulation in response to respiratory chain-generated reactive oxygen might represent a cellular adaptation to DNA damage that promotes cell survival.	reactive oxygen	137-152	thioredoxin	Homo sapiens	22-33
11411746-11	2001	A clearer delineation of the key reactive oxygen signaling pathways and the impact of various interventions on these pathways could facilitate a rationale approach to antioxidant therapy and improved outcomes among the rapidly growing number of high-risk, insulin-resistant, obese individuals.	reactive oxygen	33-48	insulin	Homo sapiens	256-263
11353799-10	2001	In summary, these data demonstrate a regulatory mechanism that is dependent on the cellular redox status, which modulates CYP2B1 mRNA induction by PB on the transcriptional level, thus representing a feedback mechanism preventing further P-450-dependent production of reactive oxygen intermediates under oxidative stress.	reactive oxygen	268-283	cytochrome P450, family 2, subfamily b, polypeptide 1	Rattus norvegicus	122-128
11380692-1	2001	Synthetic lipopeptides based on bacterial lipoprotein are efficient activators for monocytes/macrophages inducing the release of interleukin (IL)-1, IL-6, tumour necrosis factor-alpha (TNF-alpha), reactive oxygen/nitrogen intermediates, and the translocation of nuclear factor kappaB (NFkappaB).	reactive oxygen	197-212	tumor necrosis factor	Mus musculus	185-194
11171043-0	2001	Tobacco-smoke-inducible human haem oxygenase-1 gene expression: role of distinct transcription factors and reactive oxygen intermediates.	reactive oxygen	107-122	heme oxygenase 1	Homo sapiens	30-46
11086037-7	2000	The data indicate that IFN-gamma, myeloid cells, and a combination of NO and reactive oxygen intermediates all contribute to a common pathway of T cell death that targets activated or responding CD4 T cells.	reactive oxygen	77-92	CD4 antigen	Mus musculus	195-198
11935096-5	2001	As is the case for MHBs(t167), MHBsKDEL-dependent activation of NFkappaB is inhibited by the antioxidant N-acetyl-L-cysteine indicating the involvement of reactive oxygen intermediates and suggesting a similar mechanism of activation.	reactive oxygen	155-170	MHB	Homo sapiens	31-39
11935096-5	2001	As is the case for MHBs(t167), MHBsKDEL-dependent activation of NFkappaB is inhibited by the antioxidant N-acetyl-L-cysteine indicating the involvement of reactive oxygen intermediates and suggesting a similar mechanism of activation.	reactive oxygen	155-170	nuclear factor kappa B subunit 1	Homo sapiens	64-72
11211921-0	2000	Reactive oxygen intermediates and eicosanoid production by kupffer cells and infiltrated macrophages in acute and chronic liver injury induced in rats by CCl4.	reactive oxygen	0-15	C-C motif chemokine ligand 4	Rattus norvegicus	154-158
11141054-7	2001	These observations indicate that fullerene monomalonate adducts uncouple in the presence of arginine the formation of reactive oxygen intermediates from NO production by nNOS.	reactive oxygen	118-133	nitric oxide synthase 1	Homo sapiens	170-174
11759181-4	2001	The generation of reactive oxygen intermediates was estimated by means of a CD16 phycoerythrin-conjugated mouse anti-human monoclonal antibody.	reactive oxygen	18-33	Fc gamma receptor IIIa	Homo sapiens	76-80
10988295-5	2000	Structure/function analysis of TNF-R55-mediated necrosis in L929sA cells demonstrated that initiation of necrotic cell death, as defined by swelling of the cells, rapid membrane permeabilization, absence of nuclear condensation, absence of DNA hypoploidy, and generation of mitochondrial reactive oxygen intermediates, is also confined to the DD.	reactive oxygen	288-303	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	31-38
10837416-6	2000	Furthermore, SLP-76(-/-) BMM display normal Fc gamma R-dependent phagocytic function and reactive oxygen intermediate production.	reactive oxygen	89-104	lymphocyte cytosolic protein 2	Mus musculus	13-19
10837497-2	2000	Oxidative stress caused by phorbol esters or reactive oxygen up-regulates the class A scavenger receptor (SR-A) in human smooth muscle cells (SMC), which normally do not express this receptor.	reactive oxygen	45-60	macrophage scavenger receptor 1	Homo sapiens	106-110
11067959-9	2000	Leflunomide suppressed TNF-induced reactive oxygen intermediate generation and lipid peroxidation, which may explain most of its effects on TNF signaling.	reactive oxygen	35-50	tumor necrosis factor	Homo sapiens	23-26
11067959-9	2000	Leflunomide suppressed TNF-induced reactive oxygen intermediate generation and lipid peroxidation, which may explain most of its effects on TNF signaling.	reactive oxygen	35-50	tumor necrosis factor	Homo sapiens	140-143
11093125-4	2000	The results show that MCP-1 directly stimulates the elimination of intracellular Leishmania parasites by human monocytes, a potential that correlates with the induction of reactive oxygen intermediates.	reactive oxygen	172-187	C-C motif chemokine ligand 2	Homo sapiens	22-27
10913145-3	2000	To identify signaling molecules involved in this TNF-induced, reactive oxygen intermediate-dependent cell death pathway, we performed a comparative study by two-dimensional gel electrophoresis of phosphoproteins from a mitochondria-enriched fraction derived from TNF-treated and control cells.	reactive oxygen	62-77	tumor necrosis factor-like	Rattus norvegicus	49-52
11027515-0	2000	Reactive oxygen intermediates are involved in IL-8 production induced by hyperosmotic stress in human bronchial epithelial cells.	reactive oxygen	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
10843709-10	2000	Both reactive oxygen intermediate generation and lipid peroxidation induced by TNF were suppressed by resveratrol.	reactive oxygen	5-20	tumor necrosis factor	Homo sapiens	79-82
10825144-7	2000	In addition, the same treatments decreased intracellular reactive oxygen intermediate levels in B16F10 melanoma cells, indicating that IL-18 regulates reactive oxygen intermediate production, which is involved in Fas ligand expression.	reactive oxygen	57-72	interleukin 18	Mus musculus	135-140
10865848-0	2000	Participation of reactive oxygen intermediates in the angiotensin II-activated signaling pathways in vascular smooth muscle cells.	reactive oxygen	17-32	angiotensinogen	Homo sapiens	54-68
10657941-2	2000	Several pathways leading to activation of NF-kappaB have been described, including those involving reactive oxygen intermediates (ROIs) and members of the mitogen-activated protein (MAP) kinase superfamily.	reactive oxygen	99-114	nuclear factor kappa B subunit 1	Homo sapiens	42-51
10972341-1	2000	The heat-induced HSP-70 expression protects rat islet single cells against lysis mediated by nitric oxide (NO), reactive oxygen, and streptozotocin.	reactive oxygen	112-127	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	17-23
10821114-2	2000	An attractive hypothesis is that the ATM protein is involved in a specialized antioxidant system responsible for detoxifying reactive oxygen intermediate and that the absence or dysfunction of this protein in AT cells would render them less capable of dealing with oxidative stress.	reactive oxygen	125-140	ATM serine/threonine kinase	Homo sapiens	37-40
10553065-5	1999	To study the possible role of SOD-1 overexpression in thymocyte biology, we analyzed the role of reactive oxygen intermediates during in vivo and in vitro programmed cell death (PCD) induced in the thymus of Ts65Dn mice.	reactive oxygen	97-112	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	208-214
10605931-2	2000	Reactive oxygen intermediates (ROI) play several distinct roles in the p53 pathway.	reactive oxygen	0-15	tumor protein p53	Homo sapiens	71-74
10593879-10	1999	The elevated H(2)O(2) in mutant mice indicates impairment of its detoxification pathways, perhaps by changed interactions between SOD1 and H(2)O(2) detoxification enzymes.-Liu, D., Wen, J., Liu, J., Li, L. The roles of free radicals in amyotrophic lateral sclerosis: reactive oxygen species and elevated oxidation of protein, DNA, and membrane phospholipids.	reactive oxygen	267-282	superoxide dismutase 1, soluble	Mus musculus	130-134
10553065-9	1999	Thymus abnormalities were probably caused by SOD-1 hyperexpression in Ts65Dn cells, in that reactive oxygen intermediate generation (specifically H2O2 production) is enhanced in thymocytes and clearly correlates with apoptosis.	reactive oxygen	92-107	superoxide dismutase 1, soluble	Mus musculus	45-50
10553065-9	1999	Thymus abnormalities were probably caused by SOD-1 hyperexpression in Ts65Dn cells, in that reactive oxygen intermediate generation (specifically H2O2 production) is enhanced in thymocytes and clearly correlates with apoptosis.	reactive oxygen	92-107	reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65	Mus musculus	70-76
10393984-0	1999	The alternative oxidase lowers mitochondrial reactive oxygen production in plant cells.	reactive oxygen	45-60	ubiquinol oxidase 1, mitochondrial	Nicotiana tabacum	4-23
10497395-4	1999	Reactive oxygen intermediates induce some cytokine gene expression such as IL-8.	reactive oxygen	0-15	C-X-C motif chemokine ligand 8	Homo sapiens	75-79
10471544-2	1999	Moreover, VEGF has been found to be upregulated by conditions associated with the generation of free radicals and reactive oxygen intermediates.	reactive oxygen	114-129	vascular endothelial growth factor A	Homo sapiens	10-14
10507271-5	1999	RESULTS: Patients with hyper-IgE syndrome had significantly increased production of granulocyte-macrophage-colony-stimulating factor by resting or stimulated mononuclear cells, increased generation of reactive oxygen intermediates by neutrophils treated with opsonized zymosan, and reduced L-selectin expression on quiescent and activated granulocytes and lymphocytes.	reactive oxygen	201-216	selectin L	Homo sapiens	290-300
10652565-8	1999	Furthermore, production of mitochondrial reactive oxygen intermediates was retarded by overexpression of A20.	reactive oxygen	41-56	tumor necrosis factor, alpha-induced protein 3	Mus musculus	105-108
29586710-3	1999	Cu/Zn-superoxide dismutase and catalase reduce the flux of reactive oxygen molecules that are thought to be a central cause of aging.	reactive oxygen	59-74	Catalase	Drosophila melanogaster	31-39
10329352-1	1999	Reactive oxygen and nitrogen intermediates (ROI, RNI), such as superoxide anion, nitric oxide (NO) and peroxynitrite, are present in villous trophoblasts and mediate TNF-alpha-induced apoptosis in other cell types.	reactive oxygen	0-15	tumor necrosis factor	Homo sapiens	166-175
10358146-0	1999	Reactive oxygen intermediates enhance Fc gamma receptor signaling and amplify phagocytic capacity.	reactive oxygen	0-15	Fc gamma receptor Ia	Homo sapiens	38-55
10354065-6	1999	Our results show that cyclooxygenase-2 expression is induced by UV irradiation and suggest that tyrosine kinases and reactive oxygen intermediates are involved in this induction of cyclooxygenase-2.	reactive oxygen	117-132	prostaglandin-endoperoxide synthase 2	Homo sapiens	22-38
10354065-6	1999	Our results show that cyclooxygenase-2 expression is induced by UV irradiation and suggest that tyrosine kinases and reactive oxygen intermediates are involved in this induction of cyclooxygenase-2.	reactive oxygen	117-132	prostaglandin-endoperoxide synthase 2	Homo sapiens	181-197
11228742-0	1999	Activation of NF-kappa B by reactive oxygen intermediates in the nervous system.	reactive oxygen	28-43	nuclear factor kappa B subunit 1	Homo sapiens	14-24
10383851-0	1999	A reactive oxygen-generating system activates nuclear factor-kappaB and releases tumor necrosis factor-alpha in coronary smooth muscle cells.	reactive oxygen	2-17	nuclear factor kappa B subunit 1	Homo sapiens	61-67
10362713-0	1999	Reactive oxygen intermediates stimulate interleukin-6 production in human bronchial epithelial cells.	reactive oxygen	0-15	interleukin 6	Homo sapiens	40-53
9890990-1	1999	The mitochondrial protein SP-22 has recently been reported to be a member of the thioredoxin-dependent peroxide reductase family, suggesting that it may be one of the antioxidant systems in mitochondria, which are the major site of reactive oxygen intermediate generation.	reactive oxygen	232-247	Parkinsonism associated deglycase	Rattus norvegicus	26-31
10022882-0	1999	Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.	reactive oxygen	0-15	interleukin 1 beta	Homo sapiens	63-80
10022882-0	1999	Reactive oxygen intermediate-dependent NF-kappaB activation by interleukin-1beta requires 5-lipoxygenase or NADPH oxidase activity.	reactive oxygen	0-15	arachidonate 5-lipoxygenase	Homo sapiens	90-104
10554331-2	1999	NO also prevented an enhancement of the production of reactive oxygen intermediates by TNF-alpha plus actinomycin D, as assessed by the oxidation of dihydrorhodamine 123 and hydroethidine.	reactive oxygen	54-69	tumor necrosis factor	Mus musculus	87-96
9885230-0	1999	Caspases mediate tumor necrosis factor-alpha-induced neutrophil apoptosis and downregulation of reactive oxygen production.	reactive oxygen	96-111	tumor necrosis factor	Homo sapiens	17-44
9885230-2	1999	We examined here the involvement of caspases in neutrophil apoptosis and the effect of TNF-alpha-induced apoptosis on reactive oxygen production.	reactive oxygen	118-133	tumor necrosis factor	Homo sapiens	87-96
9864251-0	1999	Glucose 6-phosphate dehydrogenase is required for Salmonella typhimurium virulence and resistance to reactive oxygen and nitrogen intermediates.	reactive oxygen	101-116	glucose-6-phosphate dehydrogenase 2	Mus musculus	0-33
9882713-0	1999	Impediment to calcium influx and reactive oxygen production accounts for the inhibition of neutrophil Mac-1 Up-regulation and adhesion by tetrandrine.	reactive oxygen	33-48	integrin subunit alpha M	Homo sapiens	102-107
9915883-10	1999	Because G6PD supports reactive oxygen metabolism, the response may represent a preconditioning of antioxidant pathways in the hepatic cell populations that are targets of sinusoid-born reactive oxygen species during infections.	reactive oxygen	22-37	glucose-6-phosphate dehydrogenase	Rattus norvegicus	8-12
10541885-0	1999	Production of reactive oxygen intermediates by human macrophages exposed to soot particles and asbestos fibers and increase in NF-kappa B p50/p105 mRNA.	reactive oxygen	14-29	nuclear factor kappa B subunit 1	Homo sapiens	127-137
10541885-0	1999	Production of reactive oxygen intermediates by human macrophages exposed to soot particles and asbestos fibers and increase in NF-kappa B p50/p105 mRNA.	reactive oxygen	14-29	nuclear factor kappa B subunit 1	Homo sapiens	138-141
10541885-0	1999	Production of reactive oxygen intermediates by human macrophages exposed to soot particles and asbestos fibers and increase in NF-kappa B p50/p105 mRNA.	reactive oxygen	14-29	nuclear factor kappa B subunit 1	Homo sapiens	142-146
10554331-5	1999	Taken together, these findings indicate that the decreased mitochondrial formation of reactive oxygen intermediates in the presence of NO might have a protective effect against TNF-alpha plus actinomycin D-induced apoptosis.	reactive oxygen	86-101	tumor necrosis factor	Mus musculus	177-186
9766528-6	1998	In addition, our results suggest that ozone-induced PTK and PKA activities were reactive oxygen intermediate dependent and occurred in parallel, because specific inhibitors for PTK and PKA failed to block the other kinase"s activity.	reactive oxygen	80-95	protein tyrosine kinase 2 beta	Homo sapiens	52-55
9916892-8	1998	50% with PDTC, a scavenger of reactive oxygen intermediates (ROI) that inhibits nuclear factor kappaB (NF-kappaB) activation.	reactive oxygen	30-45	nuclear factor kappa B subunit 1	Homo sapiens	95-101
9916892-8	1998	50% with PDTC, a scavenger of reactive oxygen intermediates (ROI) that inhibits nuclear factor kappaB (NF-kappaB) activation.	reactive oxygen	30-45	nuclear factor kappa B subunit 1	Homo sapiens	103-112
9862355-0	1998	Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes.	reactive oxygen	14-29	CD40 antigen	Mus musculus	54-58
9862355-0	1998	Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes.	reactive oxygen	14-29	mitogen-activated protein kinase 8	Mus musculus	84-107
9862355-0	1998	Production of reactive oxygen intermediates following CD40 ligation correlates with c-Jun N-terminal kinase activation and IL-6 secretion in murine B lymphocytes.	reactive oxygen	14-29	interleukin 6	Mus musculus	123-127
9862377-7	1998	The FasL-induced cell death pathway in microglia involves reactive oxygen intermediates because the antioxidants N-acetylcysteine and glutathione interfere with induction of apoptosis.	reactive oxygen	58-73	Fas ligand (TNF superfamily, member 6)	Mus musculus	4-8
9766528-6	1998	In addition, our results suggest that ozone-induced PTK and PKA activities were reactive oxygen intermediate dependent and occurred in parallel, because specific inhibitors for PTK and PKA failed to block the other kinase"s activity.	reactive oxygen	80-95	protein tyrosine kinase 2 beta	Homo sapiens	177-180
9829610-0	1998	Growth hormone inhibits apoptosis and up-regulates reactive oxygen intermediates production by human polymorphonuclear neutrophils.	reactive oxygen	51-66	growth hormone 1	Homo sapiens	0-14
9743370-5	1998	Hormone-induced Tax activation induces a long-lasting activation of NF-kappaB, which is a major target of reactive oxygen intermediates.	reactive oxygen	106-121	nuclear factor kappa B subunit 1	Homo sapiens	68-77
9866925-4	1998	Once antigen-specific Th1 cells are generated, Th1-dependent macrophage activation was effective in the elimination of infected bacteria through enhanced production of reactive oxygen intermediates and reactive nitrogen intermediates.	reactive oxygen	168-183	negative elongation factor complex member C/D, Th1l	Mus musculus	22-25
9866925-4	1998	Once antigen-specific Th1 cells are generated, Th1-dependent macrophage activation was effective in the elimination of infected bacteria through enhanced production of reactive oxygen intermediates and reactive nitrogen intermediates.	reactive oxygen	168-183	negative elongation factor complex member C/D, Th1l	Mus musculus	47-50
9714456-6	1998	These results suggest that TRX induction was accompanied with reactive oxygen intermediates (ROI) overproduction and may play an important role not only in scavenging ROI but also in signal transduction during ischemia.	reactive oxygen	62-77	thioredoxin 1	Rattus norvegicus	27-30
9747040-1	1998	The CSR (cellular stress response) gene encodes a protein that structurally resembles the macrophage scavenger receptor, and is a potent regulator of intracellular reactive oxygen intermediates.	reactive oxygen	164-179	scavenger receptor class A member 3	Homo sapiens	9-33
9658163-2	1998	The primary cause of the disease is the loss of function of the Mpv17 protein, a peroxisomal gene product involved in reactive oxygen metabolism.	reactive oxygen	118-133	MpV17 mitochondrial inner membrane protein	Mus musculus	64-69
9525905-0	1998	Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression.	reactive oxygen	8-23	Fas cell surface death receptor	Homo sapiens	60-64
9525905-0	1998	Role of reactive oxygen intermediates in activation-induced CD95 (APO-1/Fas) ligand expression.	reactive oxygen	8-23	Fas cell surface death receptor	Homo sapiens	66-71
9525905-9	1998	Our data suggest that, although reactive oxygen intermediates do not act as mediators in the execution phase of CD95-mediated apoptosis, they are involved in the transcriptional regulation of CD95L expression.	reactive oxygen	32-47	Fas ligand	Homo sapiens	192-197
9657527-0	1998	Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha.	reactive oxygen	50-65	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	75-84
9657527-0	1998	Skeletal muscle myocytes undergo protein loss and reactive oxygen-mediated NF-kappaB activation in response to tumor necrosis factor alpha.	reactive oxygen	50-65	tumor necrosis factor	Mus musculus	111-138
9741337-0	1998	Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells.	reactive oxygen	72-87	CD28 molecule	Homo sapiens	8-12
9741337-0	1998	Low CD3+CD28-induced interleukin-2 production correlates with decreased reactive oxygen intermediate formation in neonatal T cells.	reactive oxygen	72-87	interleukin 2	Homo sapiens	21-34
9741337-5	1998	As NF-kappa B is a critical transcription factor in the control of IL-2 expression, we next analysed its nuclear translocation in neonatal and adult T cells using the electrophoretic mobility shift assay and, because induction of reactive oxygen intermediates (ROI) is required for the activation of NF-kappa B, we also analysed levels of intracellular ROI in these cells using the ROI-reactive fluorochrome DCFH-DA and flow cytometry.	reactive oxygen	230-245	nuclear factor kappa B subunit 1	Homo sapiens	3-13
9582369-10	1998	Overall, these results demonstrate that, in addition to several recently identified signaling molecules, reactive oxygen intermediates play a critical role in activation of NF-kappaB, activated protein-1, c-Jun kinase, and apoptosis induced by TNF and other agents.	reactive oxygen	105-120	nuclear factor kappa B subunit 1	Homo sapiens	173-182
9582369-10	1998	Overall, these results demonstrate that, in addition to several recently identified signaling molecules, reactive oxygen intermediates play a critical role in activation of NF-kappaB, activated protein-1, c-Jun kinase, and apoptosis induced by TNF and other agents.	reactive oxygen	105-120	tumor necrosis factor	Homo sapiens	244-247
9535722-1	1998	Here we analysed the involvement of tyrosine phosphorylation in the regulation of the initial molecular events induced by IL-13 to modulate TPA-triggered reactive oxygen intermediates (ROI) production.	reactive oxygen	154-169	interleukin 13	Homo sapiens	122-127
9483174-3	1997	Scavengers of reactive oxygen intermediates such as N-acetyl cysteine or pyrrolidine dithiocarbamate were able to block TF induction.	reactive oxygen	14-29	coagulation factor III, tissue factor	Homo sapiens	120-122
9372929-1	1997	Manganese superoxide dismutase (MnSOD), a tumor necrosis factor (TNF)-inducible reactive oxygen-scavenging enzyme, protects cells from TNF-mediated apoptosis.	reactive oxygen	80-95	superoxide dismutase 2, mitochondrial	Mus musculus	0-30
9372929-1	1997	Manganese superoxide dismutase (MnSOD), a tumor necrosis factor (TNF)-inducible reactive oxygen-scavenging enzyme, protects cells from TNF-mediated apoptosis.	reactive oxygen	80-95	superoxide dismutase 2, mitochondrial	Mus musculus	32-37
9372929-1	1997	Manganese superoxide dismutase (MnSOD), a tumor necrosis factor (TNF)-inducible reactive oxygen-scavenging enzyme, protects cells from TNF-mediated apoptosis.	reactive oxygen	80-95	tumor necrosis factor	Mus musculus	42-63
9372929-1	1997	Manganese superoxide dismutase (MnSOD), a tumor necrosis factor (TNF)-inducible reactive oxygen-scavenging enzyme, protects cells from TNF-mediated apoptosis.	reactive oxygen	80-95	tumor necrosis factor	Mus musculus	65-68
9372929-1	1997	Manganese superoxide dismutase (MnSOD), a tumor necrosis factor (TNF)-inducible reactive oxygen-scavenging enzyme, protects cells from TNF-mediated apoptosis.	reactive oxygen	80-95	tumor necrosis factor	Mus musculus	135-138
9353266-3	1997	We have used the model of drug-induced apoptosis to assess whether the CD95 ligand mRNA is induced by reactive oxygen intermediates.	reactive oxygen	102-117	Fas cell surface death receptor	Homo sapiens	71-75
9380028-6	1997	The transcription factor nuclear factor-kappaF (NF-kappaB) is known to be activated by many compounds, including reactive oxygen intermediates.	reactive oxygen	113-128	nuclear factor kappa B subunit 1	Homo sapiens	48-57
9353266-0	1997	Reactive oxygen intermediates are involved in the induction of CD95 ligand mRNA expression by cytostatic drugs in hepatoma cells.	reactive oxygen	0-15	Fas cell surface death receptor	Homo sapiens	63-67
9287359-10	1997	Thus, a decrease of the intracellular reactive oxygen intermediate level by hypoxia induces c-fos via the MAPK pathway.	reactive oxygen	38-53	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	92-97
9277339-2	1997	Most tissues express SERCA2 Ca2+ pumps (splice SERCA2b) which are inactivated by reactive oxygen.	reactive oxygen	81-96	ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2	Homo sapiens	21-27
8950027-4	1996	It has been shown that reactive oxygen intermediates activate NF kappa B which leads the activation of several cellular genes.	reactive oxygen	23-38	nuclear factor kappa B subunit 1	Homo sapiens	62-72
9224812-6	1997	rR-RAGE prevented albumin or inulin transfer through a bovine aortic endothelial cell monolayer, restored the hyperpermeability observed in diabetic rats or induced in normal rats by diabetic rat red blood cells, and corrected the reactive oxygen intermediate production after intravenous or intraperitoneal administration.	reactive oxygen	231-246	advanced glycosylation end product-specific receptor	Rattus norvegicus	3-7
9103454-6	1997	TNF-induced release of the decoy RII was independent of protein synthesis and reactive oxygen intermediates.	reactive oxygen	78-93	tumor necrosis factor	Homo sapiens	0-3
9070320-4	1997	Reactive oxygen (H2O2) and IL-1 production by the macrophages were also enhanced by treatment with GM-CSF.	reactive oxygen	0-15	colony stimulating factor 2 (granulocyte-macrophage)	Mus musculus	99-105
9020025-5	1997	We conclude that TNF increases the effects of reactive oxygen-induced cytotoxicity when exposed synchronously, whereas TNF pretreatment induces a cytoprotective effect to reactive oxygen species, presumably by up-regulation of the reduced form of glutathione levels in hepatocytes.	reactive oxygen	46-61	tumor necrosis factor	Rattus norvegicus	17-20
9169615-1	1997	Recent reports have demonstrated that glucose-6-phosphate dehydrogenase (G6PD) activity in mammalian cells is necessary in order to ensure cell survival when damage is produced by reactive oxygen intermediates.	reactive oxygen	180-195	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
9169615-1	1997	Recent reports have demonstrated that glucose-6-phosphate dehydrogenase (G6PD) activity in mammalian cells is necessary in order to ensure cell survival when damage is produced by reactive oxygen intermediates.	reactive oxygen	180-195	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
9042155-0	1997	Neutrophils and reactive oxygen intermediates mediate glucan-induced pulmonary granuloma formation through the local induction of monocyte chemoattractant protein-1.	reactive oxygen	16-31	C-C motif chemokine ligand 2	Rattus norvegicus	130-164
9042155-10	1997	These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression.	reactive oxygen	126-141	C-C motif chemokine ligand 2	Homo sapiens	178-183
9042155-10	1997	These in vivo data, coupled with in vitro data that indicate that both catalase-sensitive reagent H2O2 and neutrophil-derived reactive oxygen intermediates (ie, H2O2) can induce MCP-1 secretion by human umbilical vein endothelial cells, support the hypothesis that neutrophils and neutrophil-derived products (H2O2) influence granuloma formation through induction of local MCP-1 expression.	reactive oxygen	126-141	C-C motif chemokine ligand 2	Homo sapiens	373-378
9105634-6	1997	Exogenous oleic acid could also protect against the significant loss of ATPDase activity, following exposure to reactive oxygen intermediates in vitro.	reactive oxygen	112-127	ectonucleoside triphosphate diphosphohydrolase 1	Homo sapiens	72-79
8955144-1	1996	Transaldolase (TAL) is a key enzyme of the reversible nonoxidative branch of the pentose phosphate pathway (PPP) that is responsible for the generation of NADPH to maintain glutathione at a reduced state (GSH) and, thus, to protect cellular integrity from reactive oxygen intermediates (ROIs).	reactive oxygen	256-271	transaldolase 1	Homo sapiens	15-18
8863511-5	1996	Here, we describe that both IL-1 beta and TNF alpha activate the transcription factor nuclear factor-kappa B (NF-kappa B) via production of reactive oxygen intermediates resulting in ACT expression.	reactive oxygen	140-155	nuclear factor kappa B subunit 1	Homo sapiens	86-108
8863511-5	1996	Here, we describe that both IL-1 beta and TNF alpha activate the transcription factor nuclear factor-kappa B (NF-kappa B) via production of reactive oxygen intermediates resulting in ACT expression.	reactive oxygen	140-155	interleukin 1 beta	Homo sapiens	28-37
8863511-5	1996	Here, we describe that both IL-1 beta and TNF alpha activate the transcription factor nuclear factor-kappa B (NF-kappa B) via production of reactive oxygen intermediates resulting in ACT expression.	reactive oxygen	140-155	nuclear factor kappa B subunit 1	Homo sapiens	110-120
8863511-5	1996	Here, we describe that both IL-1 beta and TNF alpha activate the transcription factor nuclear factor-kappa B (NF-kappa B) via production of reactive oxygen intermediates resulting in ACT expression.	reactive oxygen	140-155	tumor necrosis factor	Homo sapiens	42-51
8870842-11	1996	Taken together, our data suggest that gp120 potentiates TNF-induced NF-kappa B activation by stimulating a signal pathway that involves p56lck and the increased formation of reactive oxygen intermediates such as H2O2.	reactive oxygen	174-189	inter-alpha-trypsin inhibitor heavy chain 4	Homo sapiens	38-43
8858119-6	1996	a sequestrant of reactive oxygen intermediates and an inhibitor of NFkappaB attenuated LPS-induced upregulation of iNOS mRNA without affecting that produced by DB-cAMP or MT-ATP.	reactive oxygen	17-32	nitric oxide synthase 2	Homo sapiens	115-119
8833917-0	1996	Reactive oxygen intermediates increase vascular endothelial growth factor expression in vitro and in vivo.	reactive oxygen	0-15	vascular endothelial growth factor A	Homo sapiens	39-73
8798554-1	1996	Evidence that reactive oxygen intermediates produced by adherent neutrophils increase the activity of the p58c-fgr and p53/56lyn tyrosine kinases.	reactive oxygen	14-29	FGR proto-oncogene, Src family tyrosine kinase	Homo sapiens	106-114
8798554-1	1996	Evidence that reactive oxygen intermediates produced by adherent neutrophils increase the activity of the p58c-fgr and p53/56lyn tyrosine kinases.	reactive oxygen	14-29	tumor protein p53	Homo sapiens	119-122
8887545-6	1996	SOK-1 is activated 3- to 7-fold by reactive oxygen intermediates, but is not activated by growth factors, alkylating agents, cytokines or environmental stresses including heat shock and osmolar stress.	reactive oxygen	35-50	serine/threonine kinase 25	Homo sapiens	0-5
8870842-11	1996	Taken together, our data suggest that gp120 potentiates TNF-induced NF-kappa B activation by stimulating a signal pathway that involves p56lck and the increased formation of reactive oxygen intermediates such as H2O2.	reactive oxygen	174-189	tumor necrosis factor	Homo sapiens	56-59
8870842-11	1996	Taken together, our data suggest that gp120 potentiates TNF-induced NF-kappa B activation by stimulating a signal pathway that involves p56lck and the increased formation of reactive oxygen intermediates such as H2O2.	reactive oxygen	174-189	nuclear factor kappa B subunit 1	Homo sapiens	68-78
8885242-3	1996	TGF beta action has been implicated in a variety of reactive oxygen-mediated tissue processes, particularly inflammation, and in pathologies such as reperfusion injury, rheumatoid arthritis, and atherosclerosis.	reactive oxygen	52-67	transforming growth factor beta 1	Homo sapiens	0-8
8754803-4	1996	This activation required reactive oxygen intermediates and the phosphorylation of IkappaBalpha at serines 32 and 36, followed by IkappaBalpha degradation and the nuclear uptake of NF-kappaB.	reactive oxygen	25-40	nuclear factor kappa B subunit 1	Homo sapiens	180-189
8732780-1	1996	We investigated, in the present study, the role of reactive oxygen intermediates (ROI) in the control of macrophage lipoprotein lipase (LPL) secretion.	reactive oxygen	51-66	lipoprotein lipase	Mus musculus	116-134
8814547-5	1996	Treatment with organic hydrogen peroxides mimicked UVB radiation in upregulating c-jun expression, suggesting the participation of reactive oxygen intermediates in the UVB-signaling pathway.	reactive oxygen	131-146	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	81-86
8668195-2	1996	Three different signals are known to elicit IRP-1 activity and thus regulate IRE-containing mRNAs: iron deficiency, nitric oxide (NO), and the reactive oxygen intermediate hydrogen peroxide (H2O2).	reactive oxygen	143-158	aconitase 1	Homo sapiens	44-49
8658528-10	1996	Since TBT causes disturbances in the respiratory chain in mitochondria, the mechanism of its action may be the production of reactive oxygen intermediates at the ubiquinone site, which activate transcription factors and promote IL-1alpha synthesis.	reactive oxygen	125-140	interleukin 1 alpha	Mus musculus	228-237
8627304-3	1996	Both protein kinase C and reactive oxygen intermediates (ROIs) were involved in IL-6 and TNF alpha gene expression by IL-1 beta.	reactive oxygen	26-41	interleukin 6	Homo sapiens	80-84
8627304-3	1996	Both protein kinase C and reactive oxygen intermediates (ROIs) were involved in IL-6 and TNF alpha gene expression by IL-1 beta.	reactive oxygen	26-41	tumor necrosis factor	Homo sapiens	89-98
8627304-3	1996	Both protein kinase C and reactive oxygen intermediates (ROIs) were involved in IL-6 and TNF alpha gene expression by IL-1 beta.	reactive oxygen	26-41	interleukin 1 beta	Homo sapiens	118-127
8732780-1	1996	We investigated, in the present study, the role of reactive oxygen intermediates (ROI) in the control of macrophage lipoprotein lipase (LPL) secretion.	reactive oxygen	51-66	lipoprotein lipase	Mus musculus	136-139
7590666-3	1995	Acute hepatic injury caused by reactive oxygen intermediate production was induced by an intraperitoneal injection of CCl4 in mice.	reactive oxygen	31-46	chemokine (C-C motif) ligand 4	Mus musculus	118-122
8568258-0	1996	Reactive oxygen intermediates as regulators of TNF-alpha production in rat lung inflammation induced by silica.	reactive oxygen	0-15	tumor necrosis factor	Rattus norvegicus	47-56
8637223-1	1996	The interaction of reactive nitrogen intermediates (RNI) with reactive oxygen intermediates (ROI) was inferred from the effect of added L-arginine on luminol-dependent chemiluminescence (LCL) and cytochrome C reduction in HL60 cells, dimethylsulphoxide (DMSO)-differentiated HL60 cells and human neutrophils.	reactive oxygen	62-77	cytochrome c, somatic	Homo sapiens	196-208
8856987-4	1996	The possibility that age-dependent changes in cellular redox status, as exemplified by the increased production of reactive oxygen inter-mediates and accumulation of oxidatively-modified proteins, affects the regulation and function of the heat shock factor 1 (HSF1) and contributes to the attenuated heat shock transcriptional response in aging cells and organisms is discussed.	reactive oxygen	115-130	heat shock transcription factor 1	Homo sapiens	240-259
8856987-4	1996	The possibility that age-dependent changes in cellular redox status, as exemplified by the increased production of reactive oxygen inter-mediates and accumulation of oxidatively-modified proteins, affects the regulation and function of the heat shock factor 1 (HSF1) and contributes to the attenuated heat shock transcriptional response in aging cells and organisms is discussed.	reactive oxygen	115-130	heat shock transcription factor 1	Homo sapiens	261-265
7592968-7	1995	The delayed onset of reactive oxygen production in response to okadaic acid correlated with the delayed activation of NF-kappa B.	reactive oxygen	21-36	nuclear factor kappa B subunit 1	Homo sapiens	118-128
7667254-2	1995	Reactive oxygen intermediates (ROIs) have been implicated in the direct cytotoxic activity of TNF.	reactive oxygen	0-15	tumor necrosis factor	Homo sapiens	94-97
8567750-3	1995	Further, both experimental and clinical evidence is accumulating to link reactive oxygen intermediates (ROI) with both cytokine induction (primarily via nuclear factor-kappa B[NF-kappa B] dependent routes) as well as the subsequent cytokine, tumor necrosis factor alpha (TNF alpha) stimulation of HIV replication.	reactive oxygen	73-88	nuclear factor kappa B subunit 1	Homo sapiens	176-186
8567750-3	1995	Further, both experimental and clinical evidence is accumulating to link reactive oxygen intermediates (ROI) with both cytokine induction (primarily via nuclear factor-kappa B[NF-kappa B] dependent routes) as well as the subsequent cytokine, tumor necrosis factor alpha (TNF alpha) stimulation of HIV replication.	reactive oxygen	73-88	tumor necrosis factor	Homo sapiens	242-269
8567750-3	1995	Further, both experimental and clinical evidence is accumulating to link reactive oxygen intermediates (ROI) with both cytokine induction (primarily via nuclear factor-kappa B[NF-kappa B] dependent routes) as well as the subsequent cytokine, tumor necrosis factor alpha (TNF alpha) stimulation of HIV replication.	reactive oxygen	73-88	tumor necrosis factor	Homo sapiens	271-280
7592595-6	1995	In sum, these data suggest that reactive oxygen intermediates are generated by heme-hemopexin via events associated with receptor binding, including protein kinase C activation.	reactive oxygen	32-47	hemopexin	Mus musculus	84-93
7769129-7	1995	Thus, cross-linking of Fc gamma RIIIb, which leads to neutrophil degranulation and the generation of reactive oxygen intermediates, in turn alters Fc gamma RIIa avidity and efficiency.	reactive oxygen	101-116	Fc gamma receptor IIIb	Homo sapiens	23-37
7641692-0	1995	IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.	reactive oxygen	69-84	interleukin 2	Homo sapiens	0-4
7641692-0	1995	IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.	reactive oxygen	69-84	nuclear factor kappa B subunit 1	Homo sapiens	25-35
7641692-0	1995	IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.	reactive oxygen	69-84	CD28 molecule	Homo sapiens	55-59
7641692-0	1995	IL-2 gene expression and NF-kappa B activation through CD28 requires reactive oxygen production by 5-lipoxygenase.	reactive oxygen	69-84	arachidonate 5-lipoxygenase	Homo sapiens	99-113
7756649-3	1995	We investigated the effect of reactive oxygen intermediates (ROIs) on vWF secretion.	reactive oxygen	30-45	von Willebrand factor	Homo sapiens	70-73
7532384-8	1995	These results suggest that TNF alpha increases mitochondrial production of reactive oxygen intermediates (ROI), which contributes to NOS induction.	reactive oxygen	75-90	tumor necrosis factor	Rattus norvegicus	27-36
7724734-2	1995	In these cell types, the radiation- and H2O2-mediated increase in c-jun mRNA levels could be prevented by pretreatment of the cells with N-acetylcysteine, an antioxidant, or H7, an inhibitor of protein kinase C and protein kinase A, but not by HA1004, a specific inhibitor of protein kinase A and G. These results suggest a role for protein kinase C and reactive oxygen intermediates in the induction of c-jun gene expression in both normal and tumor cells.	reactive oxygen	354-369	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	66-71
7896842-1	1995	Reactive oxygen intermediates like hydrogen peroxide (H2O2) have been shown to serve as messengers in the induction of NF-kappa B and, then, in the activation and replication of human immunodeficiency virus (HIV)-1 in human cells.	reactive oxygen	0-15	nuclear factor kappa B subunit 1	Homo sapiens	119-129
7876080-8	1995	Instead, Bcl-2 appears to influence levels of reactive oxygen intermediates that induce endogenous cellular antioxidants.	reactive oxygen	46-61	B cell leukemia/lymphoma 2	Mus musculus	9-14
7873605-2	1995	One was to evaluate the GR-DNA binding in extracts of COS2 cells transiently overexpressing GR and in which reactive oxygen intermediates (ROI) accumulate as a consequence of glutathione (GSH) depletion.	reactive oxygen	108-123	nuclear receptor subfamily 3 group C member 1	Homo sapiens	24-26
7890616-3	1995	We show here, the inhibitory effect of IL-13 on 12-O-tetradecanoylphorbol-13-acetate (TPA)-triggered reactive oxygen intermediate production in human monocytes and the signals involved in this response.	reactive oxygen	101-116	interleukin 13	Homo sapiens	39-44
7890616-6	1995	Metabolic inhibitors were used to relate the first steps in signaling pathways to the inhibitory effect of IL-13 on TPA-triggered reactive oxygen intermediate production.	reactive oxygen	130-145	interleukin 13	Homo sapiens	107-112
7927758-12	1994	These results indicate that (i) E. chaffeensis is sensitive to intracytoplasmic iron depletion, (ii) E. chaffeensis is sensitive to IFN-gamma-induced killing, and (iii) the anti-ehrlichial activity induced in human monocytes by IFN-gamma is mediated by limitation of available cytoplasmic iron and is not due to the generation of reactive oxygen intermediates or nitric oxide.	reactive oxygen	330-345	interferon gamma	Homo sapiens	132-141
7841193-1	1995	A model for NF kappa B activation involving reactive oxygen intermediates has recently been proposed.	reactive oxygen	44-59	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	12-22
7998983-9	1994	Thus reactive oxygen intermediates are likely mediators of LPS-induced HO-1 mRNA accumulation, and glutathione content appears to be one of the factors regulating this accumulation in the liver.	reactive oxygen	5-20	heme oxygenase 1	Mus musculus	71-75
7841193-7	1995	These results suggest that the reactive oxygen model of NF kappa B activation may be cell-type restricted.	reactive oxygen	31-46	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	56-66
7841193-11	1995	The results from this study therefore suggest that the reactive oxygen model of NF kappa B activation may be restricted to certain cell types and that the presence of such a system is not required for the activation of NF kappa B by IL1 and TNF.	reactive oxygen	55-70	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	80-90
7628061-8	1994	Direct evidence was obtained for reactive oxygen intermediates of mitochondrial origin responsible for TNF-induced cytotoxicity in L929 cells.	reactive oxygen	33-48	tumor necrosis factor	Mus musculus	103-106
7523113-6	1994	TNF cytotoxicity is mediated by reactive oxygen intermediates generated during mitochondrial respiration.	reactive oxygen	32-47	tumor necrosis factor	Mus musculus	0-3
7523500-5	1994	Thus, APC inhibited the production of TNF-alpha and prevented down-regulation of membrane CD11b, CD14, and CD18, but had no effect on up-regulation of MHC class II, ICAM-1, or IL-2R, down-regulation of MO expression of another glycophosphatidylinositol-linked protein, CD59, or production of reactive oxygen intermediates.	reactive oxygen	292-307	APC regulator of WNT signaling pathway	Homo sapiens	6-9
8076691-1	1994	The recent demonstration of the anti-oxidant properties of the Bcl-2 gene product suggested that expression of Bcl-2 may interfere with the nuclear migration of the NF-kappa B transcription factor, which is thought to depend on the presence of reactive oxygen intermediates.	reactive oxygen	244-259	B cell leukemia/lymphoma 2	Mus musculus	63-68
7965403-3	1994	The observed IL-1 alpha gene expression in the spleen was associated with the accumulation of F4/80+ macrophages in the red pulp and in the marginal zone of follicles, as well as with the relative proportions of Mac-1+ cells in the spleen and the capacity of spleen cells to produce reactive oxygen intermediates during murine malaria.	reactive oxygen	283-298	interleukin 1 alpha	Mus musculus	13-23
7929839-14	1994	Our results provide support for a role of reactive oxygen intermediates as mediators for activation of NF-kB in MC after stimulation with TNF-alpha or IgG aggregates.	reactive oxygen	42-57	tumor necrosis factor	Mus musculus	138-147
8076691-1	1994	The recent demonstration of the anti-oxidant properties of the Bcl-2 gene product suggested that expression of Bcl-2 may interfere with the nuclear migration of the NF-kappa B transcription factor, which is thought to depend on the presence of reactive oxygen intermediates.	reactive oxygen	244-259	B cell leukemia/lymphoma 2	Mus musculus	111-116
8076691-1	1994	The recent demonstration of the anti-oxidant properties of the Bcl-2 gene product suggested that expression of Bcl-2 may interfere with the nuclear migration of the NF-kappa B transcription factor, which is thought to depend on the presence of reactive oxygen intermediates.	reactive oxygen	244-259	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	165-175
7914182-1	1994	One of the mechanisms of cytotoxicity by tumor necrosis factor (TNF) and heat is the induction of reactive oxygen molecules.	reactive oxygen	98-113	tumor necrosis factor	Homo sapiens	41-62
7914182-1	1994	One of the mechanisms of cytotoxicity by tumor necrosis factor (TNF) and heat is the induction of reactive oxygen molecules.	reactive oxygen	98-113	tumor necrosis factor	Homo sapiens	64-67
7914182-2	1994	Cells producing endogenous tumor necrosis factor (enTNF) show resistance to the cytotoxicity of exogenous TNF and heat by inducing manganous superoxide dismutase (MnSOD) to scavenge the reactive oxygen molecules.	reactive oxygen	186-201	tumor necrosis factor	Homo sapiens	27-48
7914182-2	1994	Cells producing endogenous tumor necrosis factor (enTNF) show resistance to the cytotoxicity of exogenous TNF and heat by inducing manganous superoxide dismutase (MnSOD) to scavenge the reactive oxygen molecules.	reactive oxygen	186-201	tumor necrosis factor	Homo sapiens	52-55
7914182-2	1994	Cells producing endogenous tumor necrosis factor (enTNF) show resistance to the cytotoxicity of exogenous TNF and heat by inducing manganous superoxide dismutase (MnSOD) to scavenge the reactive oxygen molecules.	reactive oxygen	186-201	superoxide dismutase 2	Homo sapiens	131-161
7914182-2	1994	Cells producing endogenous tumor necrosis factor (enTNF) show resistance to the cytotoxicity of exogenous TNF and heat by inducing manganous superoxide dismutase (MnSOD) to scavenge the reactive oxygen molecules.	reactive oxygen	186-201	superoxide dismutase 2	Homo sapiens	163-168
8206709-1	1994	PURPOSE: Adult T cell leukemia derived factor (ADF) is a human homologue of thioredoxin (hTx), which exhibits scavenging activity with reactive oxygen intermediates.	reactive oxygen	135-150	thioredoxin	Homo sapiens	47-50
8024324-6	1994	Apparently, for these two quinones the predominant metabolic pathway in both the BF-2 and HepG2 cells involved redox cycling via a one-electron reduction reaction, generating reactive oxygen intermediates that consumed intracellular glutathione.	reactive oxygen	175-190	forkhead box G1	Homo sapiens	81-85
8207209-1	1994	IL-2 therapy can induce marked oxidative stress via reactive oxygen and nitrogen intermediates.	reactive oxygen	52-67	interleukin 2	Mus musculus	0-4
8206709-1	1994	PURPOSE: Adult T cell leukemia derived factor (ADF) is a human homologue of thioredoxin (hTx), which exhibits scavenging activity with reactive oxygen intermediates.	reactive oxygen	135-150	thioredoxin	Homo sapiens	76-87
8206709-1	1994	PURPOSE: Adult T cell leukemia derived factor (ADF) is a human homologue of thioredoxin (hTx), which exhibits scavenging activity with reactive oxygen intermediates.	reactive oxygen	135-150	Zic family member 3	Homo sapiens	89-92
8374773-6	1993	Several lines of evidence suggest that the actions of interferons on pyramidal cells may at least in part be mediated by reactive oxygen intermediates, known to be released from non-neuronal cells: the effects of interferon on CA3 pyramidal cells were blocked by the free radical scavengers catalase and superoxide dismutase.	reactive oxygen	121-136	carbonic anhydrase 3	Rattus norvegicus	227-230
8039809-8	1994	It is concluded therefore, that IFN-gamma enhanced the cytotoxicity of freshly isolated human blood monocytes by increasing reactive oxygen intermediate generation but was unable to enhance the tumoricidal competence of macrophages as reactive nitrogen intermediate production was unaffected.	reactive oxygen	124-139	interferon gamma	Homo sapiens	32-41
8133151-0	1994	Role of xanthine oxidase and reactive oxygen intermediates in LPS- and TNF-induced pulmonary edema.	reactive oxygen	29-44	tumor necrosis factor	Mus musculus	71-74
8302274-0	1994	Generation of reactive oxygen intermediates by human liver microsomes in the presence of NADPH or NADH.	reactive oxygen	14-29	2,4-dienoyl-CoA reductase 1	Homo sapiens	89-94
8402938-5	1993	In addition, inhibitors of reactive oxygen intermediates partially blocked the antibrucella activities exhibited by both non-cytokine-treated and IFN-gamma-activated macrophages.	reactive oxygen	27-42	interferon gamma	Mus musculus	146-155
8372889-8	1993	CONCLUSIONS: These data show that reactive oxygen produced in adenomyosis may induce Mn-SOD in ectopic endometrium, which results in the release of relatively large amounts of this protein into the peritoneal fluid.	reactive oxygen	34-49	superoxide dismutase 2	Homo sapiens	85-91
8103922-4	1993	As E. Coli lipopolysaccharide and FMLP may prime granulocytes for enhanced generation of reactive oxygen intermediates in response to other activators, the effect of beta 2-agonists on the priming effect of these agents was also investigated.	reactive oxygen	89-104	formyl peptide receptor 1	Homo sapiens	34-38
7684324-0	1993	Granulocyte colony-stimulating factor enhances the extracellular emission of reactive oxygen from neutrophils stimulated with formylmethionylleucylphenylalanine.	reactive oxygen	77-92	colony stimulating factor 3	Homo sapiens	0-37
8383168-9	1993	Macrophages produced more of this reactive oxygen intermediate in response to PAF and TPA than endothelial cells.	reactive oxygen	34-49	PCNA clamp associated factor	Homo sapiens	78-81
8480339-5	1993	To determine if these activated Kupffer cells could potentiate hepatic injury through release of reactive oxygen species upon CCl4 challenge, polyethylene glycol coupled-superoxide dismutase (PEG-SOD, 10,000 IU/kg) or -catalase (PEG-CAT, 40,000 IU/kg) was given iv 2 hr after CCl4 (0.15 ml/kg, ip) to control or VA-pretreated rats to quench any released reactive oxygen.	reactive oxygen	97-112	C-C motif chemokine ligand 4	Rattus norvegicus	126-130
8384722-0	1993	Reactive oxygen intermediates target CC(A/T)6GG sequences to mediate activation of the early growth response 1 transcription factor gene by ionizing radiation.	reactive oxygen	0-15	early growth response 1	Homo sapiens	87-110
8469926-8	1993	These findings indicate that, under suboptimal stimulation by extracellular serum, rIFN-gamma enhances the intracellular killing of catalase-negative Listeria which lack endogenous catalase acting as a scavenger of reactive oxygen intermediates.	reactive oxygen	215-230	interferon gamma	Rattus norvegicus	83-93
8382840-6	1993	Using three different techniques--the E. coli killing assay (8 patients), the production of reactive oxygen as determined by cytochrome c reduction (7 patients) and chemiluminescence (8 patients)--a significant stimulation of neutrophil function at a concentration of 10 nm IL-8 was found in all test systems.	reactive oxygen	92-107	cytochrome c, somatic	Homo sapiens	125-137
8382840-6	1993	Using three different techniques--the E. coli killing assay (8 patients), the production of reactive oxygen as determined by cytochrome c reduction (7 patients) and chemiluminescence (8 patients)--a significant stimulation of neutrophil function at a concentration of 10 nm IL-8 was found in all test systems.	reactive oxygen	92-107	C-X-C motif chemokine ligand 8	Homo sapiens	274-278
1406996-4	1992	For example, haem oxygenase is a major stress protein in human cells treated with oxidants, and reactive oxygen intermediates activate NF-kappa B, a transcriptional regulator of genes involved in inflammatory and acute-phase responses.	reactive oxygen	96-111	nuclear factor kappa B subunit 1	Homo sapiens	135-145
1423271-1	1992	One of the mechanisms of cytotoxicity by tumor necrosis factor (TNF) is the induction of reactive oxygen molecules.	reactive oxygen	89-104	tumor necrosis factor	Homo sapiens	64-67
1423271-2	1992	Cells producing endogenous tumor necrosis factor (enTNF) show resistance to the cytotoxicity of exogenous TNF by scavenging the reactive oxygen molecules.	reactive oxygen	128-143	tumor necrosis factor	Homo sapiens	52-55
1383221-7	1992	Epidermal growth factor (EGF), which promotes wound healing by stimulating cellular proliferation, was found to be a potent antagonist of reactive nitrogen and reactive oxygen intermediate production by keratinocytes.	reactive oxygen	160-175	epidermal growth factor	Mus musculus	0-23
1383221-7	1992	Epidermal growth factor (EGF), which promotes wound healing by stimulating cellular proliferation, was found to be a potent antagonist of reactive nitrogen and reactive oxygen intermediate production by keratinocytes.	reactive oxygen	160-175	epidermal growth factor	Mus musculus	25-28
1316877-0	1992	In vivo administration of recombinant growth hormone or gamma interferon activities macrophages: enhanced resistance to experimental Salmonella typhimurium infection is correlated with generation of reactive oxygen intermediates.	reactive oxygen	199-214	gonadotropin releasing hormone receptor	Rattus norvegicus	38-52
1280902-10	1992	Tumor necrosis factor alpha had both priming and enhancing effects on reactive oxygen intermediate production by chondrocytes.	reactive oxygen	70-85	tumor necrosis factor	Oryctolagus cuniculus	0-27
1510657-0	1992	Reactive oxygen-reducing and protein-refolding activities of adult T cell leukemia-derived factor/human thioredoxin.	reactive oxygen	0-15	thioredoxin	Homo sapiens	104-115
1328445-11	1992	These results indicate that although Agg-CRP enhances the intracellular generation of reactive oxygen intermediates by monocytes and neutrophils, extracellular release of those products is not influenced by cell interaction with Agg-CRP.	reactive oxygen	86-101	C-reactive protein	Homo sapiens	41-44
1660899-9	1991	These results demonstrate that the inhibition of ADCC and secretion of reactive oxygen intermediates by PM adherent to a denatured collagen/fibronectin surface correlated with an increased release of the immunosuppressive prostanoid PGE2.	reactive oxygen	71-86	fibronectin 1	Rattus norvegicus	140-151
1668118-0	1991	Platelet-activating factor stimulates receptor-mediated formation of reactive oxygen intermediates in human monocytes.	reactive oxygen	69-84	PCNA clamp associated factor	Homo sapiens	0-26
12106245-5	1991	This toxicity involved the production by brain macrophages of reactive oxygen intermediates, as shown by the protective effect of catalase, a scavenger of H2O2.	reactive oxygen	62-77	catalase	Rattus norvegicus	130-138
2065663-0	1991	Reactive oxygen intermediates as apparently widely used messengers in the activation of the NF-kappa B transcription factor and HIV-1.	reactive oxygen	0-15	nuclear factor kappa B subunit 1	Homo sapiens	92-102
2065663-4	1991	N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2.	reactive oxygen	93-108	X-linked Kx blood group	Homo sapiens	21-24
2065663-4	1991	N-acetyl-L-cysteine (NAC), a well characterized antioxidant which counteracts the effects of reactive oxygen intermediates (ROI) in living cells, prevented the activation of NF-kappa B by H2O2.	reactive oxygen	93-108	nuclear factor kappa B subunit 1	Homo sapiens	174-184
1791140-10	1991	Treatment of supernatants with either superoxide dismutase (SOD) or catalase to remove reactive oxygen products did not alter their lytic capacity.	reactive oxygen	87-102	catalase	Mus musculus	68-76
1715711-4	1991	The CD14+/CD16+ small monocytes can perform phagocytosis and they produce reactive oxygen, while their capacity for cytokine production is strongly reduced when compared to regular monocytes.	reactive oxygen	74-89	CD14 molecule	Homo sapiens	4-8
1715711-4	1991	The CD14+/CD16+ small monocytes can perform phagocytosis and they produce reactive oxygen, while their capacity for cytokine production is strongly reduced when compared to regular monocytes.	reactive oxygen	74-89	Fc gamma receptor IIIa	Homo sapiens	10-14
34502494-0	2021	Impact of Reactive Oxygen and Nitrogen Species Produced by Plasma on Mdm2-p53 Complex.	reactive oxygen	10-25	transformed mouse 3T3 cell double minute 2	Mus musculus	69-73
23932298-3	2013	The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage.	reactive oxygen	24-39	glutathione S-transferase kappa 1	Homo sapiens	63-88
23932298-3	2013	The safe elimination of reactive oxygen species and toxins via glutathione S-transferase (GST) pathways is required in order to protect cells against reactive oxygen-induced damage.	reactive oxygen	24-39	glutathione S-transferase kappa 1	Homo sapiens	90-93
34691090-6	2021	Increased Botrytis susceptibility of both the med18 and nrpd2a mutants were associated with reduced accumulation of reactive oxygen species, which are known to promote resistance to Botrytis.	reactive oxygen	116-131	mediator of RNA polymerase II transcription subunit	Arabidopsis thaliana	46-51
34502494-0	2021	Impact of Reactive Oxygen and Nitrogen Species Produced by Plasma on Mdm2-p53 Complex.	reactive oxygen	10-25	transformation related protein 53, pseudogene	Mus musculus	74-77
35437791-6	2022	Pretreatment of reactive oxygen species scavenger N-acetyl-L-cysteine (NAC), particularly mitochondrial reactive oxygen species scavengers Mito-TEMPO, effectively inhibited the activation of NLRP3 inflammasome, suggesting that nitrosamines could mediate the activation of NLRP3 inflammasome via mitochondrial reactive oxygen species (mtROS).	reactive oxygen	104-119	NLR family pyrin domain containing 3	Homo sapiens	191-196
35437791-6	2022	Pretreatment of reactive oxygen species scavenger N-acetyl-L-cysteine (NAC), particularly mitochondrial reactive oxygen species scavengers Mito-TEMPO, effectively inhibited the activation of NLRP3 inflammasome, suggesting that nitrosamines could mediate the activation of NLRP3 inflammasome via mitochondrial reactive oxygen species (mtROS).	reactive oxygen	104-119	NLR family pyrin domain containing 3	Homo sapiens	272-277
35397620-4	2022	The knockout of ICA69 in lipopolysaccharide(LPS)-induced mice markedly elevated survival ratio and heart function, while inhibiting cardiac muscle and serum inflammatory cytokines, reactive oxygen (ROS), and ferroptosis biomarkers.	reactive oxygen	181-196	islet cell autoantigen 1	Mus musculus	16-21
35181144-16	2022	Disruption of both DGAT1 and DGAT2 altered lipid homeostasis, channeling fatty acids toward oxidation and generation of reactive oxygen species.	reactive oxygen	120-135	diacylglycerol O-acyltransferase 1	Bos taurus	19-24
35181144-16	2022	Disruption of both DGAT1 and DGAT2 altered lipid homeostasis, channeling fatty acids toward oxidation and generation of reactive oxygen species.	reactive oxygen	120-135	diacylglycerol O-acyltransferase 2	Bos taurus	29-34
3095231-5	1986	An association between the capacity to form reactive oxygen intermediates and the downregulation of MHC-class II antigen expression was observed.	reactive oxygen	44-59	major histocompatibility complex, class II, DR beta 6 (pseudogene)	Homo sapiens	100-120
35286340-10	2022	Resistin was associated with increased production of neutrophil reactive oxygen species, a decrease in circulating neutrophils at 6 h and an increase in peritoneal Ly6Chi monocytes at 6 h and 24 h post-sepsis.	reactive oxygen	64-79	resistin	Mus musculus	0-8
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	reactive oxygen	301-316	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-5
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	reactive oxygen	301-316	glucose-6-phosphate dehydrogenase	Homo sapiens	38-71
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	reactive oxygen	301-316	glucose-6-phosphate dehydrogenase	Homo sapiens	73-77
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	reactive oxygen	301-316	glutathione-disulfide reductase	Homo sapiens	150-171
35216131-4	2022	NADPH, as produced from the action of glucose-6-phosphate dehydrogenase (G6PD), has an important role in redox homeostasis, serving as a cofactor for glutathione reductase in the recycling of glutathione from oxidized glutathione and for NADPH oxidases and nitric oxide synthases in the generation of reactive oxygen (ROS) and nitrogen species (RNS).	reactive oxygen	301-316	2,4-dienoyl-CoA reductase 1	Homo sapiens	238-243
2556968-0	1989	NADH-dependent microsomal interaction with ferric complexes and production of reactive oxygen intermediates.	reactive oxygen	78-93	2,4-dienoyl-CoA reductase 1	Homo sapiens	0-4
2558149-0	1989	Atrial natriuretic peptide protects hepatocytes against damage induced by hypoxia and reactive oxygen.	reactive oxygen	86-101	natriuretic peptide A	Rattus norvegicus	0-26
3029060-8	1987	The complement-enhancing effect of the anthracyclines can be completely inhibited by the reactive oxygen scavengers superoxide dismutase, catalase, and dimethyl sulfoxide.	reactive oxygen	89-104	catalase	Homo sapiens	138-146
3040807-4	1987	Studies of the mechanism of suppression revealed (a) a classical opioid receptor is involved (suppression was antagonized by naloxone and was specific for the NH2 terminus of beta-END), (b) monocytes are the primary target cell for opioids (monocyte-depleted lymphocyte preparations showed little suppression), and (c) reactive oxygen intermediates (ROI) and prostaglandin E2 are important mediators (scavengers of ROI and indomethacin eliminated the suppression).	reactive oxygen	319-334	proopiomelanocortin	Homo sapiens	175-183
34050627-0	2021	Catalytic-Enhanced Lactoferrin-Functionalized Au-Bi2 Se3 Nanodots for Parkinson"s Disease Therapy via Reactive Oxygen Attenuation and Mitochondrial Protection.	reactive oxygen	102-117	lactotransferrin	Mus musculus	19-30
3005368-10	1986	Intracolonic generation of reactive oxygen by xanthine-xanthine oxidase increased colonic mucosal ornithine decarboxylase activity and [3H]thymidine incorporation into DNA approximately twofold.	reactive oxygen	27-42	ornithine decarboxylase 1	Rattus norvegicus	98-121
6430792-2	1984	Histaminase is simultaneously inactivated by the reactive oxygen intermediates generated by the respiratory burst.	reactive oxygen	49-64	amine oxidase copper containing 1	Homo sapiens	0-11
34050627-0	2021	Catalytic-Enhanced Lactoferrin-Functionalized Au-Bi2 Se3 Nanodots for Parkinson"s Disease Therapy via Reactive Oxygen Attenuation and Mitochondrial Protection.	reactive oxygen	102-117	immunoglobulin kappa variable 1-132	Mus musculus	49-52
32402072-15	2021	A TRANSLATIONAL PERSPECTIVE: We clearly demonstrated that febuxostat, an inhibitor of xanthine oxidase (XO), prevents exercise intolerance and skeletal muscle abnormalities (mitochondrial dysfunction and atrophy) via the suppression of XO-derived reactive oxygen species increase during hypoxia (e.g., myocardial infarction [MI]) in skeletal muscle during the early phase of heart failure (HF) model mouse.	reactive oxygen	247-262	xanthine dehydrogenase	Mus musculus	86-102
32959226-5	2021	Lipocalin 2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	reactive oxygen	105-120	lipocalin 2	Homo sapiens	0-11
32959226-5	2021	Lipocalin 2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	reactive oxygen	105-120	lipocalin 2	Homo sapiens	13-17
33962063-6	2021	Collectively, our data indicate that QSOX1 is a redox sensor that negatively regulates plant immunity by linking reactive oxygen- and reactive nitrogen-signaling to limit ROS production.	reactive oxygen	113-128	quiescin sulfhydryl oxidase 1	Homo sapiens	37-42
33828089-7	2021	Reducing reactive oxygen concentrations inhibited Kv1.3-induced proliferation.	reactive oxygen	9-24	potassium voltage-gated channel subfamily A member 3	Homo sapiens	50-55
33561013-5	2021	Immune complex-stimulated neutrophils produced both mitochondrial reactive oxygen species (mitoROS) and the activated form of caspase-2 in IRE1alpha-dependent fashion, while inhibition of IRE1alpha mitigated immune complex-mediated NETosis (both in human neutrophils and in a mouse model of lupus).	reactive oxygen	66-81	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	139-148
33561013-5	2021	Immune complex-stimulated neutrophils produced both mitochondrial reactive oxygen species (mitoROS) and the activated form of caspase-2 in IRE1alpha-dependent fashion, while inhibition of IRE1alpha mitigated immune complex-mediated NETosis (both in human neutrophils and in a mouse model of lupus).	reactive oxygen	66-81	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	188-197
33593294-3	2021	Notably, mitochondrial fission mediated by dynamin-related protein 1 (Drp1) is an upstream pathway of reactive oxygen production.	reactive oxygen	102-117	dynamin 1-like	Rattus norvegicus	43-68
33593294-3	2021	Notably, mitochondrial fission mediated by dynamin-related protein 1 (Drp1) is an upstream pathway of reactive oxygen production.	reactive oxygen	102-117	dynamin 1-like	Rattus norvegicus	70-74
32402072-15	2021	A TRANSLATIONAL PERSPECTIVE: We clearly demonstrated that febuxostat, an inhibitor of xanthine oxidase (XO), prevents exercise intolerance and skeletal muscle abnormalities (mitochondrial dysfunction and atrophy) via the suppression of XO-derived reactive oxygen species increase during hypoxia (e.g., myocardial infarction [MI]) in skeletal muscle during the early phase of heart failure (HF) model mouse.	reactive oxygen	247-262	xanthine dehydrogenase	Mus musculus	104-106
30933439-11	2019	Mechanistically, TRPM2 downregulation causes an increase in the intracellular levels of reactive oxygen (ROS) and nitrogen (RNS) species, which in turn causes DNA damage and JNK activation leading to G2/M arrest, and an ultimate cell death.	reactive oxygen	88-103	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	17-22
33353078-9	2020	Reactive oxygen species analysis showed that inhibition of cytosolic and plastidic G6PDH activities leads to increased H2O2 and O2- contents in highland barley under salt and drought stresses.	reactive oxygen	0-15	g6pdh	Hordeum vulgare	83-88
32699028-0	2020	MYB30 orchestrates systemic reactive oxygen signaling and plant acclimation.	reactive oxygen	28-43	myb domain protein 30	Arabidopsis thaliana	0-5
32897469-7	2020	At the same time, reactive oxygen (ROS) generated from intracellularly delivered Ce6 by laser irradiation arrested the activity of ABCG2 efflux receptor overexpressed in doxorubicin-resistant breast cancer cells (MCF-7/ADR), resulting in increased the chemotherapy efficacy.	reactive oxygen	18-33	aldo-keto reductase family 1 member B	Homo sapiens	219-222
32975106-2	2020	The main properties of ferroptosis are free redox-active iron and consequent iron-dependent peroxidation of polyunsaturated fatty acids in cell membrane phospholipids, which results in the accumulation of lipid-based reactive oxygen species due to loss of glutathione peroxidase 4 activity.	reactive oxygen	217-232	glutathione peroxidase 4	Homo sapiens	256-280
32934948-5	2020	Effective factors on beta-cells mitochondrial function in production of compounds such as tricarboxylic acid intermediates, glutamate, nicotinamide adenine dinucleotide phosphate, and reactive oxygen species can have great effects on the secretion of insulin under diabetes.	reactive oxygen	184-199	insulin	Homo sapiens	251-258
31121492-9	2019	Additionally, LPS stimulation also promoted the production of intracellular reactive oxygen (ROS), which further induced the NLRP3 translocation to the cytoplasm from the nucleus.	reactive oxygen	76-91	NLR family, pyrin domain containing 3	Mus musculus	125-130
30871254-4	2019	Lipocalin-2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	reactive oxygen	105-120	lipocalin 2	Rattus norvegicus	0-11
30871254-4	2019	Lipocalin-2 (LCN2) is involved in the control of innate immune responses, regulation of excess iron, and reactive oxygen production.	reactive oxygen	105-120	lipocalin 2	Rattus norvegicus	13-17
33436551-0	2021	SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1alpha and reactive oxygen species.	reactive oxygen	91-106	sirtuin 6	Homo sapiens	0-5
33414419-4	2021	Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1beta release.	reactive oxygen	14-29	NLR family pyrin domain containing 3	Homo sapiens	98-103
33414419-4	2021	Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1beta release.	reactive oxygen	14-29	NLR family pyrin domain containing 3	Homo sapiens	105-144
33414419-4	2021	Mitochondrial reactive oxygen species (mtROS) driven by gefitinib stimulated the formation of the NLRP3 (NACHT, LRR and PYD-containing protein 3) inflammasome, leading to mature-IL-1beta release.	reactive oxygen	14-29	interleukin 1 alpha	Homo sapiens	178-186
33059156-5	2021	The reactive oxygen species produced by light or microbial metabolism could have contributed to the mineralization of poorly bioavailable OC through photochemical and biogenic Fenton processes catalyzed by the indigenous Fe in lake water.	reactive oxygen	4-19	bone gamma-carboxyglutamate protein	Homo sapiens	138-140
32913139-5	2020	In fact, during the reduction of substrates, NQO2 generates fairly unstable intermediates that reoxidize immediately back to the original quinone, creating a futile cycle, the byproducts of which are deleterious reactive oxygen species.	reactive oxygen	212-227	N-ribosyldihydronicotinamide:quinone reductase 2	Homo sapiens	45-49
32991157-6	2020	Accumulating studies suggest that SIRT5 is involved in regulating diverse biological processes, such as reactive oxygen defense, fatty acid metabolism and apoptosis.	reactive oxygen	104-119	sirtuin 5	Homo sapiens	34-39
31093763-1	2020	AIMS: Xanthine oxidoreductase (XOR) is an enzyme regulating uric acid synthesis and generation of reactive oxygen species.	reactive oxygen	98-113	xanthine dehydrogenase	Homo sapiens	6-29
31093763-1	2020	AIMS: Xanthine oxidoreductase (XOR) is an enzyme regulating uric acid synthesis and generation of reactive oxygen species.	reactive oxygen	98-113	xanthine dehydrogenase	Homo sapiens	31-34
31285783-8	2019	SIRT7 knockdown significantly increased the LPS-stimulated production of inflammatory mediators, like reactive oxygen and nitric oxide, and upregulated TAB1 and TLR4.	reactive oxygen	102-117	sirtuin 7	Bos taurus	0-5
30933439-11	2019	Mechanistically, TRPM2 downregulation causes an increase in the intracellular levels of reactive oxygen (ROS) and nitrogen (RNS) species, which in turn causes DNA damage and JNK activation leading to G2/M arrest, and an ultimate cell death.	reactive oxygen	88-103	mitogen-activated protein kinase 8	Mus musculus	174-177
30196988-4	2018	The formation of reactive oxygen (ROS) and nitrogen species (RNS) was determined by flow cytometry (FACS) after staining of cells with specific fluorescent dyes.	reactive oxygen	17-32	acyl-CoA synthetase long-chain family member 1	Mus musculus	100-104
30403990-14	2018	CB2 receptor seems to modulate RV adaptation through expression of contractile elements, reactive oxygen scavenger enzymes, and inflammatory response in order to prevent cardiomyocyte apoptosis.	reactive oxygen	89-104	cannabinoid receptor 2 (macrophage)	Mus musculus	0-3
29702613-5	2018	This survey highlights the pivotal role of Cu/Zn superoxide dismutase 1 (SOD1) in the production of reactive oxygen and electrophilic species in cells exposed to cell-permeable chemicals.	reactive oxygen	100-115	superoxide dismutase 1	Homo sapiens	73-77
29545196-0	2018	High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.	reactive oxygen	66-81	mucin 2, oligomeric mucus/gel-forming	Homo sapiens	5-9
29545196-0	2018	High MUC2 Mucin Expression and Misfolding Induce Cellular Stress, Reactive Oxygen Production, and Apoptosis in Goblet Cells.	reactive oxygen	66-81	LOC100508689	Homo sapiens	10-15
29031483-1	2018	Dual oxygenases (DUOX) 1 and 2, expressed in many animal tissues, participate in host defense at mucosal surfaces and may have important signaling roles through generation of reactive oxygen.	reactive oxygen	175-190	dual oxidase 1	Homo sapiens	0-30
29669993-7	2018	So, the antibacterial activities of MPO involve the production of reactive oxygen and reactive nitrogen species.	reactive oxygen	66-81	myeloperoxidase	Homo sapiens	36-39
29432840-0	2018	T-2 toxin-induced toxicity in neuroblastoma-2a cells involves the generation of reactive oxygen, mitochondrial dysfunction and inhibition of Nrf2/HO-1 pathway.	reactive oxygen	80-95	brachyury 2	Mus musculus	0-3
28762556-0	2017	NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1alpha and p27Kip1 expression in malignant melanoma and other human tumors.	reactive oxygen	31-46	NADPH oxidase 5	Homo sapiens	0-15
29272019-4	2017	Nitrate reduction method was used to measure the content of nitric oxide (NO) and radioimmunoassay was used to measure endothelin-1; Western blot assay was used to detect the expression of B-cell lymphoma-2 (Bcl-2), and flow cytometry was used to detect the intracellular level of reactive oxygen (ROS) and apoptosis of HUVECs.	reactive oxygen	281-296	BCL2 apoptosis regulator	Homo sapiens	208-213
28762556-0	2017	NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1alpha and p27Kip1 expression in malignant melanoma and other human tumors.	reactive oxygen	31-46	NADPH oxidase 5	Homo sapiens	17-21
28762556-0	2017	NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1alpha and p27Kip1 expression in malignant melanoma and other human tumors.	reactive oxygen	31-46	hypoxia inducible factor 1 subunit alpha	Homo sapiens	76-86
28762556-0	2017	NADPH oxidase 5 (NOX5)-induced reactive oxygen signaling modulates normoxic HIF-1alpha and p27Kip1 expression in malignant melanoma and other human tumors.	reactive oxygen	31-46	cyclin dependent kinase inhibitor 1B	Homo sapiens	91-98
27913620-5	2017	We have also shown that H7N9 and A/Puerto Rico/H1N1 (PR8)PB1-F2 peptide treatment induces significant mitochondrial reactive oxygen production, which contributes to NLRP3 activation.	reactive oxygen	116-131	NLR family, pyrin domain containing 3	Mus musculus	165-170
28924227-14	2017	This leads to decreased antioxidant levels and consequently to oxidative stress-i.e. the accumulation of reactive oxygen molecules, damaging the cells component and impairing cell functioning-which in turn affects the functioning of the antioxidant pathway, including xCT.	reactive oxygen	105-120	solute carrier family 7 member 11	Homo sapiens	268-271
28637879-13	2017	We also found that a pathway involving high glucose-reactive oxygen species-nuclear factor-kappaB increases platelet P2Y12 receptor expression in diabetes mellitus.	reactive oxygen	52-67	purinergic receptor P2Y12	Homo sapiens	117-122
28441405-4	2017	Mutants of MED18 and MED20 display down-regulation of genes associated with jasmonate signaling and biosynthesis while up-regulation of salicylic acid associated pathogenesis related genes and reactive oxygen producing and scavenging genes.	reactive oxygen	193-208	mediator of RNA polymerase II transcription subunit	Arabidopsis thaliana	11-16
26294083-8	2016	The activities of reactive oxygen scavenger enzymes, including superoxide dismutase, peroxidase, ascorbate peroxidase and catalase, were consistent with the accumulation of reactive oxygen species.	reactive oxygen	18-33	iron superoxide dismutase	Solanum lycopersicum	63-83
27391020-2	2016	Although some studies showed that SGLT2 inhibition attenuated reactive oxygen generation in diabetic kidney the role of SGLT2 inhibition is unknown.	reactive oxygen	62-77	solute carrier family 5 (sodium/glucose cotransporter), member 2	Mus musculus	34-39
27349915-0	2016	The LIKE SEX FOUR2 regulates root development by modulating reactive oxygen species homeostasis in Arabidopsis.	reactive oxygen	60-75	dual specificity protein phosphatase (DsPTP1) family protein	Arabidopsis thaliana	4-18
26843528-6	2016	ATR-101 caused mitochondrial hyperpolarization, reactive oxygen release, and ATP depletion within hours after exposure, followed by cytochrome c release, caspase-3/7 activation, and membrane permeabilization.	reactive oxygen	48-63	ATR serine/threonine kinase	Homo sapiens	0-3
26843528-8	2016	When combined with ATR-101, lipophilic free radical scavengers suppressed the reactive oxygen release, and glycolytic precursors prevented the ATP depletion, abrogating ATR-101 cytotoxicity.	reactive oxygen	78-93	ATR serine/threonine kinase	Homo sapiens	19-22
26843528-10	2016	ATR-101 administration to guinea pigs caused oxidized lipofuscin accumulation in the zona fasciculate layer of the adrenal cortex, implicating reactive oxygen release in the adrenalytic effect of ATR-101.	reactive oxygen	143-158	serine/threonine-protein kinase ATR	Cavia porcellus	0-3
26843528-10	2016	ATR-101 administration to guinea pigs caused oxidized lipofuscin accumulation in the zona fasciculate layer of the adrenal cortex, implicating reactive oxygen release in the adrenalytic effect of ATR-101.	reactive oxygen	143-158	ATR serine/threonine kinase	Homo sapiens	196-199
27612394-5	2017	RAGE engagement by ligands AGE, beta-amyloid peptide, and S100 calgranulin induces a stimulation of NADPH oxidase, reactive oxygen intermediate formation, NFkappaB activation and gene transcription.	reactive oxygen	115-130	long intergenic non-protein coding RNA 914	Homo sapiens	0-4
27612394-5	2017	RAGE engagement by ligands AGE, beta-amyloid peptide, and S100 calgranulin induces a stimulation of NADPH oxidase, reactive oxygen intermediate formation, NFkappaB activation and gene transcription.	reactive oxygen	115-130	amyloid beta precursor protein	Homo sapiens	32-52
27612394-5	2017	RAGE engagement by ligands AGE, beta-amyloid peptide, and S100 calgranulin induces a stimulation of NADPH oxidase, reactive oxygen intermediate formation, NFkappaB activation and gene transcription.	reactive oxygen	115-130	S100 calcium binding protein B	Homo sapiens	58-62
26294083-8	2016	The activities of reactive oxygen scavenger enzymes, including superoxide dismutase, peroxidase, ascorbate peroxidase and catalase, were consistent with the accumulation of reactive oxygen species.	reactive oxygen	18-33	peroxidase	Solanum lycopersicum	85-95
26294083-8	2016	The activities of reactive oxygen scavenger enzymes, including superoxide dismutase, peroxidase, ascorbate peroxidase and catalase, were consistent with the accumulation of reactive oxygen species.	reactive oxygen	18-33	peroxidase	Solanum lycopersicum	107-117
25715797-6	2015	Both EP2 antagonists and reactive oxygen scavengers block microglial death induced by either LPS/IL-13 or EP2 activation.	reactive oxygen	25-40	prostaglandin E receptor 2	Rattus norvegicus	106-109
27880996-7	2016	Yoga and meditation cause significant decline inOS and ODD and aid in regulating OS levels such that reactive oxygen speues meditated signal transduction, geneexpression and several other physiological functions are not disrupted.	reactive oxygen	101-116	nitric oxide synthase 2	Homo sapiens	46-50
26600675-5	2015	We suggest AIR12 is an extracellular constituent linking both hormone and reactive oxygen signaling in plants.	reactive oxygen	74-89	auxin-induced in root cultures-like protein	Arabidopsis thaliana	11-16
25785008-1	2015	BACKGROUND: Glutathione S-transferase (GST) family genes are of vital importance in maintaining cellular defence systems, protecting cells against the toxic effects of reactive oxygen produced during the synthesis of melanin, and detoxifying environmental mutagens and chemical or synthetic drugs.	reactive oxygen	168-183	glutathione S-transferase kappa 1	Homo sapiens	12-37
25063056-1	2015	Nitric oxide (NO) produced by the nitric oxide synthase (NOS) enzyme is a reactive oxygen molecule widely considered as important participant in the immune system of different organisms to confront microbial infections.	reactive oxygen	74-89	nitric oxide synthase 2	Homo sapiens	34-55
25710908-4	2015	Notably, Ly6C(high)CCR2(+) monocytes governed parasite control due to production of proinflammatory mediators, such as IL-1alpha, IL-1beta, IL-6, inducible NO synthase, TNF, and reactive oxygen intermediate.	reactive oxygen	178-193	lymphocyte antigen 6 complex, locus C1	Mus musculus	9-13
25664248-7	2015	Ang 1-7 reduces vasoconstriction, water retention, salt intake, cell proliferation, and reactive oxygen stress, and also has a renoprotective effect.	reactive oxygen	88-103	angiopoietin 1	Homo sapiens	0-5
25785008-1	2015	BACKGROUND: Glutathione S-transferase (GST) family genes are of vital importance in maintaining cellular defence systems, protecting cells against the toxic effects of reactive oxygen produced during the synthesis of melanin, and detoxifying environmental mutagens and chemical or synthetic drugs.	reactive oxygen	168-183	glutathione S-transferase kappa 1	Homo sapiens	39-42
24595981-9	2014	EPO activates signaling cascades that increase the brain"s resistance to ischemia-reperfusion stress by stabilizing mitochondrial membranes, limiting formation of reactive oxygen and nitrogen intermediates, and suppressing pro-inflammatory cytokine production and neutrophil infiltration.	reactive oxygen	163-178	erythropoietin	Homo sapiens	0-3
25218290-10	2014	CONCLUSION: The lower susceptibility of female mice is achieved by the improved detoxification of reactive oxygen due to accelerated recovery of mitochondrial GSH levels, which attenuates late JNK activation and liver injury.	reactive oxygen	98-113	mitogen-activated protein kinase 8	Mus musculus	193-196
27407221-4	2015	So far, research on leptin"s influence on the emission of reactive oxygen intermediates (ROI) measured with chemiluminescence (CL) has provided unclear and contradictory results.	reactive oxygen	58-73	leptin	Homo sapiens	20-26
24929952-4	2014	Estradiol, acting predominantly via the ERalpha, inhibits angiotensin II activation of the area postrema and subfornical organ neurons and inhibits reactive oxygen generation that is required for the development of Angiotensin II-induced neurogenic hypertension.	reactive oxygen	148-163	estrogen receptor 1	Homo sapiens	40-47
25312135-2	2014	METHODS: PMA and FMLP were used to artificially stimulate reactive oxygen production in cultured promonocytic U937 cell line.	reactive oxygen	58-73	formyl peptide receptor 1	Homo sapiens	17-21
24929952-4	2014	Estradiol, acting predominantly via the ERalpha, inhibits angiotensin II activation of the area postrema and subfornical organ neurons and inhibits reactive oxygen generation that is required for the development of Angiotensin II-induced neurogenic hypertension.	reactive oxygen	148-163	angiotensinogen	Homo sapiens	215-229
24360748-5	2014	(2) Downregulation of FFAR1 expression reduced the attenuating effect of PIO on the expression of NAPDH oxidase subunit p47(phox), Bax, cleaved caspase 3, and the production of reactive oxygen specific (ROS) induced by lipotoxicity, thereby preventing the upregulation of the expression of bcl-2.	reactive oxygen	177-192	free fatty acid receptor 1	Mus musculus	22-27
24585933-8	2014	Functional assays show that SP-D inhibits the production of FcalphaR-mediated reactive oxygen via LAIR-1.	reactive oxygen	78-93	surfactant protein D	Homo sapiens	28-32
24585933-8	2014	Functional assays show that SP-D inhibits the production of FcalphaR-mediated reactive oxygen via LAIR-1.	reactive oxygen	78-93	Fc alpha receptor	Homo sapiens	60-68
24585933-8	2014	Functional assays show that SP-D inhibits the production of FcalphaR-mediated reactive oxygen via LAIR-1.	reactive oxygen	78-93	leukocyte associated immunoglobulin like receptor 1	Homo sapiens	98-104
24128087-12	2014	Beyond their role in metabolism, mitochondria are the main source of reactive oxygen intermediates (ROI), which activate mTOR and regulate the activity of histone and DNA modifying enzymes.	reactive oxygen	69-84	mechanistic target of rapamycin kinase	Homo sapiens	121-125
24089324-11	2014	CONCLUSION: The reactive oxygen/nitrogen species-PARP pathway plays a pathogenetic role in the development of liver inflammation, metabolism, and fibrosis.	reactive oxygen	16-31	poly (ADP-ribose) polymerase family, member 1	Mus musculus	49-53
24518113-4	2014	The ulceration phenotype likely represents the genotype of the reactive oxygen driven tumor, in which reactive oxygen drives angiopoietin-2 production, tumor growth, and invasion.	reactive oxygen	63-78	angiopoietin 2	Homo sapiens	125-139
24518113-4	2014	The ulceration phenotype likely represents the genotype of the reactive oxygen driven tumor, in which reactive oxygen drives angiopoietin-2 production, tumor growth, and invasion.	reactive oxygen	102-117	angiopoietin 2	Homo sapiens	125-139
23509693-0	2013	An inherited heteroplasmic mutation in mitochondrial gene COI in a patient with prostate cancer alters reactive oxygen, reactive nitrogen and proliferation.	reactive oxygen	103-118	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	58-61
23875749-0	2014	Interaction of inducible nitric oxide synthase with rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes: implication in microbial killing.	reactive oxygen	67-82	nitric oxide synthase 2	Homo sapiens	15-46
23875749-0	2014	Interaction of inducible nitric oxide synthase with rac2 regulates reactive oxygen and nitrogen species generation in the human neutrophil phagosomes: implication in microbial killing.	reactive oxygen	67-82	Rac family small GTPase 2	Homo sapiens	52-56
23741359-0	2013	Endothelial nitric oxide synthase reduces crescentic and necrotic glomerular lesions, reactive oxygen production, and MCP1 production in murine lupus nephritis.	reactive oxygen	86-101	nitric oxide synthase 3, endothelial cell	Mus musculus	0-33
22139133-0	2012	FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression.	reactive oxygen	17-32	forkhead box O3	Homo sapiens	0-6
22842044-4	2012	CD14(+)CD16(-) monocytes showed a higher production of reactive oxygen and nitrogen intermediates after stimulation with tumor cells, and more pronounced inhibition of tumor growth in vivo.	reactive oxygen	55-70	CD14 molecule	Homo sapiens	0-4
22842044-4	2012	CD14(+)CD16(-) monocytes showed a higher production of reactive oxygen and nitrogen intermediates after stimulation with tumor cells, and more pronounced inhibition of tumor growth in vivo.	reactive oxygen	55-70	Fc gamma receptor IIIa	Homo sapiens	7-11
22974734-5	2013	hMTH1 expression reverted the decreased mitochondrial membrane potential characteristic of Hdh(Q111) cells and delayed the increase in mitochondrial reactive oxygen species associated with 3-NP treatment.	reactive oxygen	149-164	nudix hydrolase 1	Homo sapiens	0-5
22902620-2	2012	Dectin-1 binds to beta-glucans in fungal cell walls and triggers phagocytosis, production of reactive oxygen by the NADPH oxidase, and inflammatory cytokine production which all contribute to host immune responses against fungi.	reactive oxygen	93-108	C-type lectin domain containing 7A	Homo sapiens	0-8
22902620-5	2012	Further, Dectin-1 directs the recruitment of LC3II to phagosomes, and this requires Syk, activation of reactive oxygen production by the NADPH oxidase, and ATG5.	reactive oxygen	103-118	C-type lectin domain containing 7A	Homo sapiens	9-17
22809160-1	2012	Nitrate reductase (NR) and peroxidase (POX) are important enzymes involved in the metabolism of reactive oxygen (ROS) and nitrogen species in leaves of wheat (Triticum aestivum L.) seedlings.	reactive oxygen	96-111	peroxidase-like	Triticum aestivum	27-37
22809160-1	2012	Nitrate reductase (NR) and peroxidase (POX) are important enzymes involved in the metabolism of reactive oxygen (ROS) and nitrogen species in leaves of wheat (Triticum aestivum L.) seedlings.	reactive oxygen	96-111	peroxidase-like	Triticum aestivum	39-42
22348594-2	2012	Furthermore, the toxic intracellular environment (accumulation of reactive oxygen/nitrosative species and intracellular calcium) during post-ischemic reperfusion triggers Bax-dependent mitochondrial permeabilization (MP) leading to activation of caspase-dependent and apoptosis-inducing factor dependent cell death.	reactive oxygen	66-81	BCL2 associated X, apoptosis regulator	Homo sapiens	171-174
22615571-4	2012	This localization permits Sod3 to protect yeasts specifically from exogenous superoxide whereas amelioration of endogenous reactive oxygen depends on intracellular dismutases such as Sod1.	reactive oxygen	123-138	superoxide dismutase SOD1	Saccharomyces cerevisiae S288C	183-187
22102807-3	2011	Activation of the P2X7 receptor opens a cation-specific channel that alters the ionic environment of the cell, activating several pathways, including (i) the inflammasome, leading to production of IL-1beta and IL-18; (ii) the stress-activated protein kinase pathway, resulting in apoptosis; (iii) the mitogen-activated protein kinase pathway, leading to generation of reactive oxygen and nitrogen intermediates; and (iv) phospholipase D, stimulating phagosome-lysosome fusion.	reactive oxygen	368-383	purinergic receptor P2X 7	Homo sapiens	18-31
22379935-11	2011	Chlamydiasis statistically increases production of Reactive Oxygen Forms what results in unfavorable outcome of the pregnancy Increase of the following parameters was observed: Superoxide Dysmutase (5583.2 vs 8980.2U/ml/sec) and Catalase (15.1 vs 18.3U/ml/sec).	reactive oxygen	51-66	catalase	Homo sapiens	229-237
21726593-2	2011	Nuclear factor-kappaB (NF-kappaB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis.	reactive oxygen	73-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-21
21726593-2	2011	Nuclear factor-kappaB (NF-kappaB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis.	reactive oxygen	73-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	23-32
20606163-4	2010	Therefore, we carried out a series of experiments in mice and humans, finding that COX1 is the predominant isoform active in PG synthesis during infection and that its prophylactic or therapeutic inhibition primes leukocytes to kill bacteria by increasing phagocytic uptake and reactive oxygen intermediate-mediated killing in a cyclic adenosine monophosphate (cAMP)-dependent manner.	reactive oxygen	278-293	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	83-87
21602054-10	2011	Apart from increased level of Granzyme A and Granzyme B, IL-15 cultured T cells exhibited increased accumulation of reactive oxygen (ROS) and reactive nitrogen species (RNS) as compared to IL-2 cultured T cells.	reactive oxygen	116-131	interleukin 15	Homo sapiens	57-62
21572097-9	2011	Thus, AIF has a critical function in APAP hepatotoxicity by facilitating generation of reactive oxygen in mitochondria and, after nuclear translocation, AIF can be involved in DNA fragmentation.	reactive oxygen	87-102	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	6-9
21148796-0	2011	Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.	reactive oxygen	111-126	protein kinase D1	Mus musculus	0-16
21148796-0	2011	Protein kinase D orchestrates the activation of DRAK2 in response to TCR-induced Ca2+ influx and mitochondrial reactive oxygen generation.	reactive oxygen	111-126	serine/threonine kinase 17b (apoptosis-inducing)	Mus musculus	48-53
21631290-1	2011	Cytoglobin is a recently identified vertebrate globin whose functions include scavenging reactive oxygen and nitrosative species.	reactive oxygen	89-104	cytoglobin	Homo sapiens	0-10
21376121-11	2011	Both reactive oxygen-dependent and -independent antioxidant-sensitive pathways for GATA4 activation have also been demonstrated.	reactive oxygen	5-20	GATA binding protein 4	Homo sapiens	83-88
21481475-6	2011	HMOX1, an indicator of stress due to reactive oxygen intermediates (ROIs) and/or metals, was upregulated at the later time point as well.	reactive oxygen	37-52	heme oxygenase 1	Homo sapiens	0-5
21324895-3	2011	c-Jun N-terminal kinase-1 (JNK-1) is a stress-regulated kinase that is activated by reactive oxygen and thought to promote injury during severe acute myocardial infarction.	reactive oxygen	84-99	mitogen-activated protein kinase 8	Mus musculus	0-25
21324895-3	2011	c-Jun N-terminal kinase-1 (JNK-1) is a stress-regulated kinase that is activated by reactive oxygen and thought to promote injury during severe acute myocardial infarction.	reactive oxygen	84-99	mitogen-activated protein kinase 8	Mus musculus	27-32
21321110-7	2011	Our findings suggest that the pro-inflammatory cytokine IFN-gamma initiates a Duox2-mediated reactive oxygen cascade in human pancreatic cancer cells; reactive oxygen species production in this setting could contribute to the pathophysiologic characteristics of these tumors.	reactive oxygen	93-108	interferon gamma	Homo sapiens	56-65
21321110-7	2011	Our findings suggest that the pro-inflammatory cytokine IFN-gamma initiates a Duox2-mediated reactive oxygen cascade in human pancreatic cancer cells; reactive oxygen species production in this setting could contribute to the pathophysiologic characteristics of these tumors.	reactive oxygen	93-108	dual oxidase 2	Homo sapiens	78-83
21701161-7	2011	They regulated the intrinsic mitochondrial cell death signaling pathway and modulated activation of caspases, Bax, iNOS, p53, NF-kappaB, and mitogen-activated protein kinases (p38 and JNK) through different reactive oxygen and nitrosative species.	reactive oxygen	207-222	mitogen-activated protein kinase 14	Homo sapiens	176-179
21701161-7	2011	They regulated the intrinsic mitochondrial cell death signaling pathway and modulated activation of caspases, Bax, iNOS, p53, NF-kappaB, and mitogen-activated protein kinases (p38 and JNK) through different reactive oxygen and nitrosative species.	reactive oxygen	207-222	mitogen-activated protein kinase 8	Homo sapiens	184-187
21099112-6	2010	Here we demonstrate that a moderate increase in expression of hepcidin in beta-thalassemic mice limits iron overload, decreases formation of insoluble membrane-bound globins and reactive oxygen species, and improves anemia.	reactive oxygen	178-193	hepcidin antimicrobial peptide	Mus musculus	62-70
21038848-0	2010	Diallyl disulfide induces apoptosis in human leukemia HL-60 cells through activation of JNK mediated by reactive oxygen.	reactive oxygen	104-119	mitogen-activated protein kinase 8	Homo sapiens	88-91
20163451-8	2010	Vitamin C also decreased intracellular reactive oxygen intermediates (ROI) levels that were increased by LL-37.	reactive oxygen	39-54	cathelicidin antimicrobial peptide	Homo sapiens	105-110
20479003-0	2010	Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.	reactive oxygen	116-131	tumor necrosis factor	Mus musculus	53-80
20479003-0	2010	Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production.	reactive oxygen	116-131	chloride channel, voltage-sensitive 3	Mus musculus	90-95
19861159-12	2010	Three major mechanisms are discussed to be involved in enhancing the PHD activity despite the lack of oxygen: (1) NO mediated induction of a HIF-1 dependent feedback loop leading to newly expressed PHD2 and enhanced nuclear localization, (2) O2-redistribution towards PHDs after inhibition of mitochondrial respiration by NO, (3) reactivation of PHD activity by a NO mediated increase of iron and 2-oxoglutarate and/or involvement of reactive oxygen and/or nitrogen species.	reactive oxygen	434-449	hypoxia inducible factor 1 subunit alpha	Homo sapiens	141-146
20437156-5	2010	The clpP mutant derived from D39 (serotype 2) exhibited a higher sensitivity to oxidative stresses such as reactive oxygen intermediates, reactive nitrogen intermediates, and H(2)O(2), but no sensitivity to osmotic stress (NaCl) and pH.	reactive oxygen	107-122	caseinolytic mitochondrial matrix peptidase proteolytic subunit	Mus musculus	4-8
20018867-0	2010	Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration.	reactive oxygen	0-15	NADPH oxidase 1	Rattus norvegicus	29-44
20018867-0	2010	Reactive oxygen generated by NADPH oxidase 1 (Nox1) contributes to cell invasion by regulating matrix metalloprotease-9 production and cell migration.	reactive oxygen	0-15	NADPH oxidase 1	Rattus norvegicus	46-50
19941472-6	2010	In vitro studies have suggested that the neuroprotective role of Nb may be due to its ability to scavenge reactive oxygen (ROS) and nitrogen (RNS) species.	reactive oxygen	106-121	neuroglobin	Homo sapiens	65-67
19519662-2	2009	We report here that MOPr-mediated activation of PLD2 stimulates production of reactive oxygen molecules via NADH/NADPH oxidase.	reactive oxygen	78-93	phospholipase D2	Homo sapiens	48-52
19837977-5	2009	The CD11b(high)Ly6C(+) cells in this malaria infection display effector functions such as production of inducible nitric oxide synthase and reactive oxygen intermediates, and phagocytose P chabaudi parasites in vitro, and in a proportion of the cells, in vivo in the spleen, suggesting possible mechanisms of parasite killing.	reactive oxygen	140-155	integrin subunit alpha M	Homo sapiens	4-9
19837977-5	2009	The CD11b(high)Ly6C(+) cells in this malaria infection display effector functions such as production of inducible nitric oxide synthase and reactive oxygen intermediates, and phagocytose P chabaudi parasites in vitro, and in a proportion of the cells, in vivo in the spleen, suggesting possible mechanisms of parasite killing.	reactive oxygen	140-155	lymphocyte antigen 6 complex, locus C1	Mus musculus	15-19
19587216-5	2009	Events upstream of NF-kappaB, including integrin activation, Rac activation, reactive oxygen production, and degradation of IkappaB, were FAK independent.	reactive oxygen	77-92	nuclear factor kappa B subunit 1	Homo sapiens	19-28
19477209-4	2009	Angiotensin II plays critical roles in the progression of chronic kidney disease through its vasoconstrictor action, stimulatory action on cell proliferation, and reactive oxygen-generating activity.	reactive oxygen	163-178	angiotensinogen	Homo sapiens	0-14
19437283-5	2009	Delivery of the ELR-CXC chemokine antagonist CXCL8(3-74)K11R/G31P (G31P) blocked reactive oxygen intermediate production and chemotactic responses by IL-8-challenged neutrophils in vitro.	reactive oxygen	81-96	C-X-C motif chemokine ligand 12	Sus scrofa	20-33
19495415-7	2009	According to our data SOD3 has a selective anti-inflammatory role in ischemic damages preventing the migration of reactive oxygen producing monocyte/macrophages, which in excessive amounts could potentially further intensify the tissue injuries therefore suggesting potential for SOD3 in treatment of inflammatory disorders.	reactive oxygen	114-129	superoxide dismutase 3	Rattus norvegicus	22-26
19159661-10	2009	Reactive oxygen or carbonyl species participate in this process presumably via stimulation of the TRPA1 channel.	reactive oxygen	0-15	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	98-103
19437283-5	2009	Delivery of the ELR-CXC chemokine antagonist CXCL8(3-74)K11R/G31P (G31P) blocked reactive oxygen intermediate production and chemotactic responses by IL-8-challenged neutrophils in vitro.	reactive oxygen	81-96	C-X-C motif chemokine ligand 8	Sus scrofa	45-50
19437283-5	2009	Delivery of the ELR-CXC chemokine antagonist CXCL8(3-74)K11R/G31P (G31P) blocked reactive oxygen intermediate production and chemotactic responses by IL-8-challenged neutrophils in vitro.	reactive oxygen	81-96	C-X-C motif chemokine ligand 8	Sus scrofa	150-154
21832625-0	2008	Reactive oxygen plasma-enabled synthesis of nanostructured CdO: tailoring nanostructures through plasma-surface interactions.	reactive oxygen	0-15	cell adhesion associated, oncogene regulated	Homo sapiens	59-62
18728404-0	2008	The JNK signaling pathway is involved in sodium-selenite-induced apoptosis mediated by reactive oxygen in HepG2 cells.	reactive oxygen	87-102	mitogen-activated protein kinase 8	Homo sapiens	4-7
18620057-4	2008	Toll-like receptor-mediated pathways, the complement cascade and reactive oxygen generation induce nuclear factor (NF)-kappaB activation and upregulate chemokine and cytokine synthesis in the infarcted heart.	reactive oxygen	65-80	nuclear factor kappa B subunit 1	Homo sapiens	99-125
18327972-0	2008	Reactive oxygen and reactive nitrogen as signaling molecules for caspase 3 activation in acute cardiac transplant rejection.	reactive oxygen	0-15	caspase 3	Homo sapiens	65-74
18765096-5	2008	Angiotensin II in brain neurons affects other neurons both through activation of angiotensin receptors and via generation of nitric oxide and reactive oxygen molecules.	reactive oxygen	142-157	angiotensinogen	Homo sapiens	0-14
18543263-6	2008	This condition has been shown to promote insulin resistance by interfering with phosphorylation of proteins of the insulin pathway including insulin receptor substrate-1/2 (IRS), phosphatidylinositol-3-kinase, (PI3-kinase) and protein kinase C. Although the molecular mechanism is not completely understood, elevated reactive oxygen (ROS) and nitrogen species (RNS) are involved in this process.	reactive oxygen	317-332	insulin	Homo sapiens	41-48
18543263-6	2008	This condition has been shown to promote insulin resistance by interfering with phosphorylation of proteins of the insulin pathway including insulin receptor substrate-1/2 (IRS), phosphatidylinositol-3-kinase, (PI3-kinase) and protein kinase C. Although the molecular mechanism is not completely understood, elevated reactive oxygen (ROS) and nitrogen species (RNS) are involved in this process.	reactive oxygen	317-332	insulin	Homo sapiens	115-122
18543263-6	2008	This condition has been shown to promote insulin resistance by interfering with phosphorylation of proteins of the insulin pathway including insulin receptor substrate-1/2 (IRS), phosphatidylinositol-3-kinase, (PI3-kinase) and protein kinase C. Although the molecular mechanism is not completely understood, elevated reactive oxygen (ROS) and nitrogen species (RNS) are involved in this process.	reactive oxygen	317-332	insulin	Homo sapiens	115-122
18336980-2	2008	Nuclear factor-kappaB (NF-kappaB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis.	reactive oxygen	73-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	0-21
18336980-2	2008	Nuclear factor-kappaB (NF-kappaB) is a transcription factor activated by reactive oxygen and is involved in cell proliferation and apoptosis.	reactive oxygen	73-88	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	23-32
18171027-6	2008	Subsequent studies performed to determine the effects of reactive oxygen and reactive nitrogen species on DDAH activity demonstrated that low level oxidant exposure had little effect on enzyme activity and that concentrations approaching >or=100 microM were needed to confer significant inhibition of DDAH activity.	reactive oxygen	57-72	dimethylarginine dimethylaminohydrolase 1	Homo sapiens	106-110
18081811-11	2008	Therefore, AMPK may be a therapeutic modulation target for treatment of the dentine-pulp complex injured by reactive oxygen.	reactive oxygen	108-123	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	11-15
18082129-7	2008	These findings extend our understanding of the homeostatic function of UCP2 in regulating mitochondrial reactive oxygen production by identifying a feedback loop that senses mitochondrial reactive oxygen production and increases inner mitochondrial membrane UCP2 abundance and activity.	reactive oxygen	104-119	uncoupling protein 2	Homo sapiens	71-75
18055552-0	2007	Nox1 expression determines cellular reactive oxygen and modulates c-fos-induced growth factor, interleukin-8, and Cav-1.	reactive oxygen	36-51	NADPH oxidase 1	Homo sapiens	0-4
18501881-6	2008	It has been observed that IL-13 significantly inhibits the ROI generation in all macrophage types while by neutralizing with invivo administration of IL-13R*2 and/or potentiation with Th1 cytokine, the production of reactive oxygen intermediate increases, which indicates that IL-13R*2 and/or potentiation with Th1 cytokine could restore the cytotoxic ability of macrophage in a murine T-cell lymphoma.	reactive oxygen	216-231	interleukin 13	Mus musculus	26-31
18751914-5	2008	TNF-alpha and IL-1 alter lipid metabolism and stimulate production of eicosanoids, ceramide, and reactive oxygen species that potentiate CNS injuries and certain neurological disorders.	reactive oxygen	97-112	tumor necrosis factor	Homo sapiens	0-9
18751914-5	2008	TNF-alpha and IL-1 alter lipid metabolism and stimulate production of eicosanoids, ceramide, and reactive oxygen species that potentiate CNS injuries and certain neurological disorders.	reactive oxygen	97-112	interleukin 1 alpha	Homo sapiens	14-18
17996682-6	2007	Thus, hbG31P blocked the abilities of human CXCL8 to chemoattract human neutrophil or induce reactive oxygen intermediate (ROI) release.	reactive oxygen	93-108	C-X-C motif chemokine ligand 8	Homo sapiens	44-49
17452475-8	2007	Furthermore, VacA-induced NF-kappaB activation and chemokine release from eosinophils were dependent on Ca(2+) influx and mitochondrial generation of reactive oxygen intermediates (ROI).	reactive oxygen	150-165	nuclear factor kappa B subunit 1	Homo sapiens	26-35
17913887-3	2007	Comparison of microarray expression profiles of Listeria monocytogenes (LM)-infected macrophages from WT and NF-IL6-deficient mice enabled us to identify candidate genes downstream of NF-IL6 involved in the unknown pathways of LM killing independent of reactive oxygen intermediates and reactive nitrogen intermediates.	reactive oxygen	253-268	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	109-115
17603930-6	2007	The levels of reactive oxygen (ROS) and reactive nitrogen species (RNS), both intracellularly and in the medium, were higher for LNCaP cells than for PC3 cells during cell growth.	reactive oxygen	14-29	chromobox 8	Homo sapiens	150-153
17508921-1	2007	Reactive oxygen (ROS) and nitrogen species (RNS) generation have been proposed to be an important mechanism of doxorubicin (Adriamycin; ADR)-induced cardiotoxicity and cardiomyocyte apoptosis, processes that may be mediated by p53 protein.	reactive oxygen	0-15	transformation related protein 53, pseudogene	Mus musculus	227-230
17209006-1	2007	c-Jun NH(2)-terminal kinase (JNK), a member of the MAPK family of protein kinases, is a stress-response kinase that is activated by proinflammatory cytokines and growth factors coupled to membrane receptors or through nonreceptor pathways by stimuli such as heat shock, UV irradiation, protein synthesis inhibitors, and conditions that elevate the levels of reactive oxygen intermediates (ROI).	reactive oxygen	358-373	mitogen-activated protein kinase 8	Homo sapiens	0-27
17579088-0	2007	Apis mellifera venom and melittin block neither NF-kappa B-p50-DNA interactions nor the activation of NF-kappa B, instead they activate the transcription of proinflammatory genes and the release of reactive oxygen intermediates.	reactive oxygen	198-213	melittin	Apis mellifera	25-33
17209006-1	2007	c-Jun NH(2)-terminal kinase (JNK), a member of the MAPK family of protein kinases, is a stress-response kinase that is activated by proinflammatory cytokines and growth factors coupled to membrane receptors or through nonreceptor pathways by stimuli such as heat shock, UV irradiation, protein synthesis inhibitors, and conditions that elevate the levels of reactive oxygen intermediates (ROI).	reactive oxygen	358-373	mitogen-activated protein kinase 8	Homo sapiens	29-32
17196988-2	2007	This study sought to characterize the relevance of superoxide dismutases (SOD), a family of reactive oxygen catalyzing metalloenzymes, including manganese SOD (MnSOD), copper-zinc SOD (CuZnSOD), and extracellular SOD (EcSOD), in a rodent aortic aneurysm model.	reactive oxygen	92-107	superoxide dismutase 1	Rattus norvegicus	74-77
17372019-2	2007	We showed previously that SLP-76 is required for neutrophil function in vitro, including integrin-induced adhesion and production of reactive oxygen intermediates, and to a lesser extent, FcgammaR-induced calcium flux and reactive oxygen intermediate production.	reactive oxygen	133-148	lymphocyte cytosolic protein 2	Mus musculus	26-32
17372019-2	2007	We showed previously that SLP-76 is required for neutrophil function in vitro, including integrin-induced adhesion and production of reactive oxygen intermediates, and to a lesser extent, FcgammaR-induced calcium flux and reactive oxygen intermediate production.	reactive oxygen	222-237	lymphocyte cytosolic protein 2	Mus musculus	26-32
17196988-2	2007	This study sought to characterize the relevance of superoxide dismutases (SOD), a family of reactive oxygen catalyzing metalloenzymes, including manganese SOD (MnSOD), copper-zinc SOD (CuZnSOD), and extracellular SOD (EcSOD), in a rodent aortic aneurysm model.	reactive oxygen	92-107	superoxide dismutase 2	Rattus norvegicus	145-158
17196988-2	2007	This study sought to characterize the relevance of superoxide dismutases (SOD), a family of reactive oxygen catalyzing metalloenzymes, including manganese SOD (MnSOD), copper-zinc SOD (CuZnSOD), and extracellular SOD (EcSOD), in a rodent aortic aneurysm model.	reactive oxygen	92-107	superoxide dismutase 2	Rattus norvegicus	160-165
17196988-2	2007	This study sought to characterize the relevance of superoxide dismutases (SOD), a family of reactive oxygen catalyzing metalloenzymes, including manganese SOD (MnSOD), copper-zinc SOD (CuZnSOD), and extracellular SOD (EcSOD), in a rodent aortic aneurysm model.	reactive oxygen	92-107	superoxide dismutase 1	Rattus norvegicus	185-192
17052484-5	2006	RESULTS: We have previously demonstrated that EBV-induced reactive oxygen is associated with hypermethylation of the tumor suppressor gene p16 in Burkitt lymphoma, and that p16 hypermethylation is nearly always associated with EBV infection in Burkitt lymphoma.	reactive oxygen	58-73	cyclin dependent kinase inhibitor 2A	Homo sapiens	139-142
17097638-0	2007	Bax affects production of reactive oxygen by the mitochondria of non-apoptotic neurons.	reactive oxygen	26-41	BCL2-associated X protein	Mus musculus	0-3
17116243-7	2006	The WT and V30M TTR mutant (valine 30 substituted with methionine) were allowed to react over a time range of 10 min to 12 h with hydroxy radical and other reactive oxygen species.	reactive oxygen	156-171	transthyretin	Homo sapiens	16-19
17571974-3	2007	Expression of uPA is regulated in part by the oxidant-sensitive transcription factor, NF-kappa B (NF-kappaB), which is activated by intracellular reactive oxygen intermediates (ROI).	reactive oxygen	146-161	plasminogen activator, urokinase	Homo sapiens	14-17
17571974-3	2007	Expression of uPA is regulated in part by the oxidant-sensitive transcription factor, NF-kappa B (NF-kappaB), which is activated by intracellular reactive oxygen intermediates (ROI).	reactive oxygen	146-161	nuclear factor kappa B subunit 1	Homo sapiens	86-96
17571974-3	2007	Expression of uPA is regulated in part by the oxidant-sensitive transcription factor, NF-kappa B (NF-kappaB), which is activated by intracellular reactive oxygen intermediates (ROI).	reactive oxygen	146-161	nuclear factor kappa B subunit 1	Homo sapiens	98-107
16866623-5	2006	In vitro experiments revealed that microglial endostatin release is induced predominantly by hypoxia and, to a lesser extent, by reactive oxygen intermediates.	reactive oxygen	129-144	collagen type XVIII alpha 1 chain	Homo sapiens	46-56
16793534-5	2006	Various AGE inhibitors have been developed in recent years, and their underlying mechanism is based on the attenuation of glycoxidation and/or oxidative stress by the sequestration of metal ions, reactive 1,2-dicarbonyl compounds, and reactive oxygen and reactive nitrogen species.	reactive oxygen	235-250	renin binding protein	Homo sapiens	8-11
16171772-8	2006	The oxidative potential of MPO involves an array of intermediate-generated reactive oxygen and reactive nitrogen species and the ability of MPO to generate chlorinating oxidants-in particular hypochlorous acid/hypochlorite-under physiological conditions is a unique and defining activity for this enzyme.	reactive oxygen	75-90	myeloperoxidase	Homo sapiens	27-30
16493074-6	2006	Although the life span of neutrophils was unaffected, these cells, when stimulated via hOSCAR, rapidly released reactive oxygen intermediates, degranulated lactoferrin, myeloperoxidase, and matrix metalloproteinase-9 and also secreted IL-8/CXCL8.	reactive oxygen	112-127	osteoclast associated Ig-like receptor	Homo sapiens	87-93
16636067-0	2006	Nox1-dependent reactive oxygen generation is regulated by Rac1.	reactive oxygen	15-30	NADPH oxidase 1	Homo sapiens	0-4
16636067-0	2006	Nox1-dependent reactive oxygen generation is regulated by Rac1.	reactive oxygen	15-30	Rac family small GTPase 1	Homo sapiens	58-62
16407785-0	2005	Reactive oxygen intermediates and serum antioxidative system in patients with chronic C hepatitis treated with IFN-alpha and thymus factor X.	reactive oxygen	0-15	interferon alpha 1	Homo sapiens	111-120
17718406-0	2006	Alcohol metabolism"s damaging effects on the cell: a focus on reactive oxygen generation by the enzyme cytochrome P450 2E1.	reactive oxygen	62-77	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	103-122
16305961-4	2005	RESULTS: The myoblasts treated with low concentration of reactive oxygen (50 micromol/L H(2)O(2)) for 1 h exhibited accelerated cell growth (P<0.05), and treatment with 50 and 150 micromol/L H(2)O(2) induced the gene expression of myogenin, a molecular marker for differentiation of myoblasts.	reactive oxygen	57-72	myogenin	Homo sapiens	234-242
16141403-0	2005	CD40 ligand influences platelet release of reactive oxygen intermediates.	reactive oxygen	43-58	CD40 antigen	Mus musculus	0-4
15956283-4	2005	Here we report that Dectin-1 activates Syk in macrophages and is important for Dectin-1-stimulated reactive oxygen production, but not for phagocytosis.	reactive oxygen	99-114	C-type lectin domain containing 7A	Homo sapiens	79-87
15994299-6	2005	Small interfering RNAs decreased endogenous p22phox expression and inhibited reactive oxygen generation from Nox1, Nox2, Nox3, and Nox4 but not Nox5.	reactive oxygen	77-92	calcineurin like EF-hand protein 1	Homo sapiens	44-47
15956283-0	2005	Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.	reactive oxygen	78-93	C-type lectin domain containing 7A	Homo sapiens	0-8
15956283-0	2005	Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production.	reactive oxygen	78-93	spleen associated tyrosine kinase	Homo sapiens	19-22
15956283-1	2005	Dectin-1 is a lectin receptor for beta-glucan that is important for innate macrophage recognition of fungi and contributes to phagocytosis, reactive oxygen production, and induction of inflammatory cytokines.	reactive oxygen	140-155	C-type lectin domain containing 7A	Homo sapiens	0-8
15956283-4	2005	Here we report that Dectin-1 activates Syk in macrophages and is important for Dectin-1-stimulated reactive oxygen production, but not for phagocytosis.	reactive oxygen	99-114	C-type lectin domain containing 7A	Homo sapiens	20-28
15994299-6	2005	Small interfering RNAs decreased endogenous p22phox expression and inhibited reactive oxygen generation from Nox1, Nox2, Nox3, and Nox4 but not Nox5.	reactive oxygen	77-92	NADPH oxidase 1	Homo sapiens	109-113
15994299-6	2005	Small interfering RNAs decreased endogenous p22phox expression and inhibited reactive oxygen generation from Nox1, Nox2, Nox3, and Nox4 but not Nox5.	reactive oxygen	77-92	cytochrome b-245 beta chain	Homo sapiens	115-119
15994299-6	2005	Small interfering RNAs decreased endogenous p22phox expression and inhibited reactive oxygen generation from Nox1, Nox2, Nox3, and Nox4 but not Nox5.	reactive oxygen	77-92	NADPH oxidase 3	Homo sapiens	121-125
15994299-6	2005	Small interfering RNAs decreased endogenous p22phox expression and inhibited reactive oxygen generation from Nox1, Nox2, Nox3, and Nox4 but not Nox5.	reactive oxygen	77-92	NADPH oxidase 4	Homo sapiens	131-135
15994299-7	2005	Truncated forms of p22phox that disrupted the PRR-inhibited reactive oxygen generation from Nox1, Nox2, and Nox3 but not from Nox4 and Nox5.	reactive oxygen	60-75	cytochrome b-245 alpha chain	Homo sapiens	19-26
15994299-7	2005	Truncated forms of p22phox that disrupted the PRR-inhibited reactive oxygen generation from Nox1, Nox2, and Nox3 but not from Nox4 and Nox5.	reactive oxygen	60-75	nuclear receptor subfamily 1 group I member 2	Homo sapiens	46-49
15994299-7	2005	Truncated forms of p22phox that disrupted the PRR-inhibited reactive oxygen generation from Nox1, Nox2, and Nox3 but not from Nox4 and Nox5.	reactive oxygen	60-75	NADPH oxidase 1	Homo sapiens	92-96
15994299-7	2005	Truncated forms of p22phox that disrupted the PRR-inhibited reactive oxygen generation from Nox1, Nox2, and Nox3 but not from Nox4 and Nox5.	reactive oxygen	60-75	cytochrome b-245 beta chain	Homo sapiens	98-102
15994299-7	2005	Truncated forms of p22phox that disrupted the PRR-inhibited reactive oxygen generation from Nox1, Nox2, and Nox3 but not from Nox4 and Nox5.	reactive oxygen	60-75	NADPH oxidase 3	Homo sapiens	108-112
15994299-8	2005	Similarly, p22phox (P156Q), a mutation that disrupts Src homology 3 binding by the PRR, potently inhibited reactive oxygen production from Nox1 and Nox2 but not from Nox4 and Nox5.	reactive oxygen	107-122	cytochrome b-245 alpha chain	Homo sapiens	11-18
15994299-8	2005	Similarly, p22phox (P156Q), a mutation that disrupts Src homology 3 binding by the PRR, potently inhibited reactive oxygen production from Nox1 and Nox2 but not from Nox4 and Nox5.	reactive oxygen	107-122	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	53-56
15994299-8	2005	Similarly, p22phox (P156Q), a mutation that disrupts Src homology 3 binding by the PRR, potently inhibited reactive oxygen production from Nox1 and Nox2 but not from Nox4 and Nox5.	reactive oxygen	107-122	nuclear receptor subfamily 1 group I member 2	Homo sapiens	83-86
15994299-8	2005	Similarly, p22phox (P156Q), a mutation that disrupts Src homology 3 binding by the PRR, potently inhibited reactive oxygen production from Nox1 and Nox2 but not from Nox4 and Nox5.	reactive oxygen	107-122	NADPH oxidase 1	Homo sapiens	139-143
15994299-8	2005	Similarly, p22phox (P156Q), a mutation that disrupts Src homology 3 binding by the PRR, potently inhibited reactive oxygen production from Nox1 and Nox2 but not from Nox4 and Nox5.	reactive oxygen	107-122	cytochrome b-245 beta chain	Homo sapiens	148-152
15718363-8	2005	However, CD11b expression and reactive oxygen intermediate production were significantly increased in normal neonatal neutrophils that were incubated with GM-CSF versus controls but not G-CSF or lipopolysaccharide.	reactive oxygen	30-45	colony stimulating factor 2	Homo sapiens	155-161
16026326-2	2005	Reactive oxygen and nitrogen species induce DNA single strand breaks, which serve as obligatory triggers for the activation of PARP.	reactive oxygen	0-15	poly(ADP-ribose) polymerase 1	Homo sapiens	127-131
15807789-6	2005	Ep5C expression is rapidly induced by H2O2, a reactive oxygen intermediate normally generated during the course of a plant-pathogen interaction.	reactive oxygen	46-61	peroxidase	Solanum lycopersicum	0-4
15695816-9	2005	We conclude that the thymus contains a functioning UCP 1 that has the capacity to regulate metabolic flux and production of reactive oxygen-containing molecules in the thymus.	reactive oxygen	124-139	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	51-56
15746179-3	2005	Since the cytokine tumor necrosis factor-alpha (TNF-alpha) stimulates both reactive oxygen production and general activity of the ubiquitin conjugating pathway, we hypothesized that TNF-alpha would also increase atrogin1/MAFbx gene expression.	reactive oxygen	75-90	tumor necrosis factor	Mus musculus	19-46
15746179-3	2005	Since the cytokine tumor necrosis factor-alpha (TNF-alpha) stimulates both reactive oxygen production and general activity of the ubiquitin conjugating pathway, we hypothesized that TNF-alpha would also increase atrogin1/MAFbx gene expression.	reactive oxygen	75-90	tumor necrosis factor	Mus musculus	48-57
15746179-3	2005	Since the cytokine tumor necrosis factor-alpha (TNF-alpha) stimulates both reactive oxygen production and general activity of the ubiquitin conjugating pathway, we hypothesized that TNF-alpha would also increase atrogin1/MAFbx gene expression.	reactive oxygen	75-90	tumor necrosis factor	Mus musculus	182-191
15601666-2	2005	During macrophage activation, Slc11a1 exerts pleiotropic effects on gene regulation and function, including generation of nitric oxide (NO) via inducible NO synthase (iNOS; encoded by Nos2A) and of reactive oxygen intermediates (ROI) via the phagocyte oxidase complex.	reactive oxygen	198-213	solute carrier family 11 (proton-coupled divalent metal ion transporters), member 1	Mus musculus	30-37
15367711-3	2004	N-acetylcysteine, a free radical scavenger, blocked induction of tumor necrosis factor-alpha by anticancer agents, supporting a role for reactive oxygen intermediates in activation of the CArG sequences.	reactive oxygen	137-152	tumor necrosis factor	Homo sapiens	65-92
15803410-5	2004	GBP1/2 are members of a conserved Plant- Specific Ankyrin- repeat (PANK) family that includes proteins implicated in carbohydrate allocation, reactive oxygen metabolism, hypersensitive cell death, rapid elicitor responses, virus pathogenesis, and auxin signaling.	reactive oxygen	142-157	single-stranded telomeric DNA-binding/mRNA-binding protein	Saccharomyces cerevisiae S288C	0-6
15528043-0	2004	Bcl-2 family proteins regulate mitochondrial reactive oxygen production and protect against oxidative stress.	reactive oxygen	45-60	BCL2 apoptosis regulator	Homo sapiens	0-5
15572693-4	2004	In contrast, mature PRAM-1-null neutrophils exhibit significant defects in adhesion-dependent reactive oxygen intermediate production and degranulation.	reactive oxygen	94-109	PML-RAR alpha-regulated adaptor molecule 1	Mus musculus	20-26
15481297-0	2004	Regulation of tumor necrosis factor-alpha production in the isolated rat heart stimulated by bacterial lipopolysaccharide or reactive oxygen.	reactive oxygen	125-140	tumor necrosis factor	Rattus norvegicus	14-41
15161907-7	2004	Mangiferin, similar to the other known antioxidants, NAC and PDTC, inhibits TNF-induced reactive oxygen intermediate (ROI) generation.	reactive oxygen	88-103	X-linked Kx blood group	Homo sapiens	53-56
15161907-7	2004	Mangiferin, similar to the other known antioxidants, NAC and PDTC, inhibits TNF-induced reactive oxygen intermediate (ROI) generation.	reactive oxygen	88-103	tumor necrosis factor	Homo sapiens	76-79
14693668-9	2004	Also based on the tissue nitrotyrosine staining, the reactive oxygen and nitrogen intermediates seemed to be reduced in tissue in CD40KO mice.	reactive oxygen	53-68	CD40 antigen	Mus musculus	130-136
15283848-1	2004	We have previously shown that human umbilical vein endothelial cells (HUVEC) can be activated by IFNgamma plus TNFalpha to kill intracellular (IC) Pseudomonas aeruginosa through production of reactive oxygen intermediate, but the cumulative effects of cytokine activation and bacterial infection on host cells has not been extensively addressed.	reactive oxygen	192-207	interferon gamma	Homo sapiens	97-105
15283848-1	2004	We have previously shown that human umbilical vein endothelial cells (HUVEC) can be activated by IFNgamma plus TNFalpha to kill intracellular (IC) Pseudomonas aeruginosa through production of reactive oxygen intermediate, but the cumulative effects of cytokine activation and bacterial infection on host cells has not been extensively addressed.	reactive oxygen	192-207	tumor necrosis factor	Homo sapiens	111-119
15356994-3	2004	Curcumin possesses anti-inflammatory activity and is a potent inhibitor of reactive oxygen-generating enzymes such as lipoxygenase/cyclooxygenase, xanthine dehydrogenase/oxidase and inducible nitric oxide synthase; and an effective inducer of heme oxygenase-1.	reactive oxygen	75-90	heme oxygenase 1	Homo sapiens	243-259
15308853-1	2004	We evaluated DNA protection effect of heat shock protein (HSP) against cytotoxic effects of exogenous nitric oxide (NO) and reactive oxygen intermediate (ROI).	reactive oxygen	124-139	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	38-56
15308853-1	2004	We evaluated DNA protection effect of heat shock protein (HSP) against cytotoxic effects of exogenous nitric oxide (NO) and reactive oxygen intermediate (ROI).	reactive oxygen	124-139	heat shock protein 90 beta family member 2, pseudogene	Homo sapiens	58-61
14730390-3	2004	Reactive oxygen intermediates have additionally been proposed to be of general importance for the expression of FAS and soluble FAS ligand (sFASL) and the subsequent induction of apoptosis.	reactive oxygen	0-15	Fas ligand	Homo sapiens	128-138
15153505-0	2004	Pulmonary surfactant protein a inhibits macrophage reactive oxygen intermediate production in response to stimuli by reducing NADPH oxidase activity.	reactive oxygen	51-66	surfactant protein A1	Homo sapiens	0-30
16871741-4	2004	Decreased activity of the sodium-proton exchanger (NHE) is one of the results of reactive oxygen forms acting on RBC.	reactive oxygen	81-96	solute carrier family 9 member C1	Homo sapiens	51-54
14980704-0	2004	Cyp1a2 protects against reactive oxygen production in mouse liver microsomes.	reactive oxygen	24-39	cytochrome P450, family 1, subfamily a, polypeptide 2	Mus musculus	0-6
15502880-10	2004	We conclude that AII, via AII receptor subtype 1 activation and reactive oxygen and nitrogen species generation, triggers DNA breakage, which activates PARP in the vascular endothelium, leading to the development of endothelial dysfunction in hypertension.	reactive oxygen	64-79	angiotensinogen	Rattus norvegicus	17-20
14651610-9	2004	The overexpression of Prx2 also increases protection against H2O2 treatment, suggesting that catalase and other peroxidases function as a defence mechanism against endogenously produced reactive oxygen intermediates and the oxidative stress imposed by the host.	reactive oxygen	186-201	catalase	Mus musculus	93-101
14597553-0	2004	The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediates.	reactive oxygen	71-86	CD82 molecule	Homo sapiens	31-34
14597553-0	2004	The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediates.	reactive oxygen	71-86	CD82 molecule	Homo sapiens	35-39
14597553-0	2004	The metastasis suppressor gene C33/CD82/KAI1 induces apoptosis through reactive oxygen intermediates.	reactive oxygen	71-86	CD82 molecule	Homo sapiens	40-44