PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
25798941-0	2015	The PKD inhibitor CID755673 enhances cardiac function in diabetic db/db mice.	CID755673	18-27	protein kinase D1	Mus musculus	4-7
25798941-8	2015	Acute administration of the PKD inhibitor CID755673 to normal mice reduced both PKD1 and 2 phosphorylation in a time and dose-dependent manner.	CID755673	42-51	protein kinase D1	Mus musculus	28-31
25798941-8	2015	Acute administration of the PKD inhibitor CID755673 to normal mice reduced both PKD1 and 2 phosphorylation in a time and dose-dependent manner.	CID755673	42-51	polycystin 1, transient receptor potential channel interacting	Mus musculus	80-90
23430742-4	2013	RNAi against PKD2 and treatment with the PKD inhibitor CID755673 showed that PKD activity is dispensable for induction of bone marrow macrophages into tartrate-resistant acid phosphatase-positive preosteoclasts in culture but is required for the transition from mononucleated preosteoclasts to multinucleated osteoclasts.	CID755673	55-64	protein kinase D1	Homo sapiens	41-44
22488958-11	2012	Finally, we found that inhibition of PKD by CID755673 significantly suppressed UDP-induced engulfment of IgG-opsonized microspheres.	CID755673	44-53	protein kinase D1	Homo sapiens	37-40
30906439-9	2019	The expression of PKD1, HDAC5 and VEGF mRNA and protein in myocardial tissue of model group and CID755673 inhibitor group were significantly lower than the other four groups (P<0.05), whereas these levels in the AS-IV group were significantly higher than those in the other five groups (P<0.01).	CID755673	96-105	vascular endothelial growth factor A	Rattus norvegicus	34-38
22470346-8	2012	PKD/PKD1 inhibition by CID755673 significantly ameliorated necrosis and severity of pancreatitis in an in vivo experimental model of acute pancreatitis.	CID755673	23-32	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	4-8
21617763-4	2011	The benzoxoloazepinolone CID755673 was recently identified as the first potent and selective PKD inhibitor.	CID755673	25-34	protein kinase D1	Homo sapiens	93-96
19896460-1	2010	Recently, CID755673 was reported to act as a highly selective inhibitor of protein kinase D (PKD).	CID755673	10-19	protein kinase D1	Mus musculus	75-91
19896460-1	2010	Recently, CID755673 was reported to act as a highly selective inhibitor of protein kinase D (PKD).	CID755673	10-19	protein kinase D1	Mus musculus	93-96
19896460-3	2010	These stimulatory effects could be dissociated from the inhibitory effect of CID755673 on PKD activity, since enhancement of DNA synthesis was still evident in cells with severely down-regulated PKD1 after transfection of siRNA targeting PKD1.	CID755673	77-86	protein kinase D1	Mus musculus	90-93
19896460-3	2010	These stimulatory effects could be dissociated from the inhibitory effect of CID755673 on PKD activity, since enhancement of DNA synthesis was still evident in cells with severely down-regulated PKD1 after transfection of siRNA targeting PKD1.	CID755673	77-86	polycystin 1, transient receptor potential channel interacting	Mus musculus	195-199
32747433-0	2020	Inhibition of protein kinase D by CID755673 promotes maintenance of the pluripotency of embryonic stem cells.	CID755673	34-43	protein kinase D1	Homo sapiens	14-30
32747433-2	2020	In this study, we showed that the protein kinase D (PKD) inhibitor CID755673 (CID) is able to maintain the undifferentiated state of mouse ESCs in combination with the mitogen-activated protein kinase kinase (MEK) inhibitor.	CID755673	67-76	protein kinase D1	Mus musculus	34-50
32747433-2	2020	In this study, we showed that the protein kinase D (PKD) inhibitor CID755673 (CID) is able to maintain the undifferentiated state of mouse ESCs in combination with the mitogen-activated protein kinase kinase (MEK) inhibitor.	CID755673	67-76	protein kinase D1	Mus musculus	52-55
32747433-2	2020	In this study, we showed that the protein kinase D (PKD) inhibitor CID755673 (CID) is able to maintain the undifferentiated state of mouse ESCs in combination with the mitogen-activated protein kinase kinase (MEK) inhibitor.	CID755673	67-76	midkine	Mus musculus	168-207
32033440-5	2020	We show that PKD inhibitors CRT0066101 and CID755673 inhibit several distinct aspects of osteoclast formation.	CID755673	43-52	protein kinase D1	Homo sapiens	13-16
30906439-9	2019	The expression of PKD1, HDAC5 and VEGF mRNA and protein in myocardial tissue of model group and CID755673 inhibitor group were significantly lower than the other four groups (P<0.05), whereas these levels in the AS-IV group were significantly higher than those in the other five groups (P<0.01).	CID755673	96-105	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	18-22
20444281-3	2010	Previously, we identified a novel pan-PKD inhibitor, CID755673, with potency in the upper nanomolar range and high selectivity for PKD.	CID755673	53-62	protein kinase D1	Homo sapiens	38-41
20444281-3	2010	Previously, we identified a novel pan-PKD inhibitor, CID755673, with potency in the upper nanomolar range and high selectivity for PKD.	CID755673	53-62	protein kinase D1	Homo sapiens	131-134
18829454-4	2008	We now report the discovery of the first potent and selective cell-active small molecule inhibitor for PKD, benzoxoloazepinolone (CID755673).	CID755673	130-139	protein kinase D1	Homo sapiens	103-106
18829454-9	2008	Functionally, CID755673 inhibited the known biological actions of PKD1 including phorbol ester-induced class IIa histone deacetylase 5 nuclear exclusion, vesicular stomatitis virus glycoprotein transport from the Golgi to the plasma membrane, and the ilimaquinone-induced Golgi fragmentation.	CID755673	14-23	polycystin 1, transient receptor potential channel interacting	Homo sapiens	66-70
18829454-11	2008	In summary, our findings indicate that CID755673 is a potent and selective PKD1 inhibitor with valuable pharmacological and cell biological potential.	CID755673	39-48	polycystin 1, transient receptor potential channel interacting	Homo sapiens	75-79
28257891-9	2017	Furthermore, intracerebroventricular injection of ataxia telangiectasia mutated (ATM) kinase inhibitor (KU-55933) significantly reduced HSP27 phosphorylation and G6PD upregulation after MCAO, but that of protein kinase D inhibitor (CID755673) did not affect HSP27 phosphorylation.	CID755673	232-241	ATM serine/threonine kinase	Rattus norvegicus	81-84
28032559-9	2017	RESULTS: BK stimulated myofibroblast migration over 24 h. BK also led to rapid and sustained phosphorylation of PKD at Ser-916, rapid phosphorylation of Hsp27 at Ser-82, and increased COX-2 expression over 4 h. BK-mediated COX-2 expression and Hsp27 phosphorylation were both inhibited by the PKD inhibitor CID755673.	CID755673	307-316	kininogen 1	Homo sapiens	58-60
28032559-9	2017	RESULTS: BK stimulated myofibroblast migration over 24 h. BK also led to rapid and sustained phosphorylation of PKD at Ser-916, rapid phosphorylation of Hsp27 at Ser-82, and increased COX-2 expression over 4 h. BK-mediated COX-2 expression and Hsp27 phosphorylation were both inhibited by the PKD inhibitor CID755673.	CID755673	307-316	kininogen 1	Homo sapiens	58-60
28032559-10	2017	Similarly, BK-induced myofibroblast migration was significantly inhibited by CID755673 (P < 0.05), by the direct COX-2 inhibitor NS398 (P < 0.05), and by Hsp27 small interfering RNA (P < 0.05).	CID755673	77-86	kininogen 1	Homo sapiens	11-13