PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32982168-2	2020	In this study, we aimed to evaluate the effectiveness of treatment of nonunion with a large radial defect using a bone-targeting liposome-encapsulated salvianic acid A (SAA-BTL)-incorporated collagen sponge and further elucidate whether the effects were closely related to histone deacetylase 3 (HDAC 3)-mediated endochondral ossification in nonunion healing process.	saa-btl	169-176	histone deacetylase 3	Oryctolagus cuniculus	273-294
32982168-2	2020	In this study, we aimed to evaluate the effectiveness of treatment of nonunion with a large radial defect using a bone-targeting liposome-encapsulated salvianic acid A (SAA-BTL)-incorporated collagen sponge and further elucidate whether the effects were closely related to histone deacetylase 3 (HDAC 3)-mediated endochondral ossification in nonunion healing process.	saa-btl	169-176	histone deacetylase 3	Oryctolagus cuniculus	296-302
32982168-9	2020	Furthermore, immunofluorescence double staining and histology analysis confirmed that SAA-BTL significantly increased the expression of P-HDAC3, collagen II, RUNX2, VEGFA, and osteocalcin in vivo; accelerated endochondral ossification turnover from cartilage to bone; and promoted long bone healing of nonunion defects.	saa-btl	86-93	runt-related transcription factor 2	Oryctolagus cuniculus	158-163
32982168-9	2020	Furthermore, immunofluorescence double staining and histology analysis confirmed that SAA-BTL significantly increased the expression of P-HDAC3, collagen II, RUNX2, VEGFA, and osteocalcin in vivo; accelerated endochondral ossification turnover from cartilage to bone; and promoted long bone healing of nonunion defects.	saa-btl	86-93	vascular endothelial growth factor A	Oryctolagus cuniculus	165-170
32982168-9	2020	Furthermore, immunofluorescence double staining and histology analysis confirmed that SAA-BTL significantly increased the expression of P-HDAC3, collagen II, RUNX2, VEGFA, and osteocalcin in vivo; accelerated endochondral ossification turnover from cartilage to bone; and promoted long bone healing of nonunion defects.	saa-btl	86-93	osteocalcin	Oryctolagus cuniculus	176-187
32982168-12	2020	Conclusion: SAA-BTL can improve nonunion healing through the regulation of HDAC3-mediated endochondral ossification.	saa-btl	12-19	histone deacetylase 3	Mus musculus	75-80