PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
8818573-6	1996	Preincubation with troleandomycin (50 microM), or gestodene (50 microM) inhibitors of CYP3A4, decreased the rate of production of norcodeine by 60 and 45% compared to control values, respectively.	norcodeine	130-140	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	86-92
17017525-4	2006	Genotyping revealed the presence of the frame-shift mutation 138delT only in those subjects who expressed the brain variant CYP2D7, which metabolizes codeine exclusively to morphine unlike hepatic CYP2D6 that metabolizes codeine to nor codeine and morphine.	norcodeine	232-243	cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene)	Homo sapiens	124-130
8818573-9	1996	Preincubation with antibodies raised to CYP3A4 (5 mg lgG/nmol P450) caused 96% inhibition of norcodeine production, whereas preimmune IgG or antibodies raised to CYP2A6 and CYP2C had no effect.	norcodeine	93-103	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	40-46
8818573-10	1996	Additionally, significant norcodeine production was observed with purified CYP3A4 derived from human liver microsomes.	norcodeine	26-36	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	75-81
31295464-9	2019	CYP3A95, which shares 79% sequence homology with human CYP3A4 and CYP2D50 catalyzed the conversion of codeine to norcodeine (Km of 104.1 and 526.9 muM, Vmax of 2.8 and 2.6 pmol/min/pmol P450).	norcodeine	113-123	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	55-61
32654915-11	2020	Morphine and norcodeine were the least abundant metabolites with Cmax of 3.17 +- 0.95 and 1.42 +- 0.79 ng mL-1, respectively.	norcodeine	13-23	L1 cell adhesion molecule	Mus musculus	106-110