PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 8818573-6 1996 Preincubation with troleandomycin (50 microM), or gestodene (50 microM) inhibitors of CYP3A4, decreased the rate of production of norcodeine by 60 and 45% compared to control values, respectively. norcodeine 130-140 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 86-92 17017525-4 2006 Genotyping revealed the presence of the frame-shift mutation 138delT only in those subjects who expressed the brain variant CYP2D7, which metabolizes codeine exclusively to morphine unlike hepatic CYP2D6 that metabolizes codeine to nor codeine and morphine. norcodeine 232-243 cytochrome P450 family 2 subfamily D member 7 (gene/pseudogene) Homo sapiens 124-130 8818573-9 1996 Preincubation with antibodies raised to CYP3A4 (5 mg lgG/nmol P450) caused 96% inhibition of norcodeine production, whereas preimmune IgG or antibodies raised to CYP2A6 and CYP2C had no effect. norcodeine 93-103 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 40-46 8818573-10 1996 Additionally, significant norcodeine production was observed with purified CYP3A4 derived from human liver microsomes. norcodeine 26-36 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 75-81 31295464-9 2019 CYP3A95, which shares 79% sequence homology with human CYP3A4 and CYP2D50 catalyzed the conversion of codeine to norcodeine (Km of 104.1 and 526.9 muM, Vmax of 2.8 and 2.6 pmol/min/pmol P450). norcodeine 113-123 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 55-61 32654915-11 2020 Morphine and norcodeine were the least abundant metabolites with Cmax of 3.17 +- 0.95 and 1.42 +- 0.79 ng mL-1, respectively. norcodeine 13-23 L1 cell adhesion molecule Mus musculus 106-110