PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
29621559-6	2018	When pretreated primary neurons with calpain inhibitor PD150606 or cyclin-dependent kinase (cdk5, the downstream complex of calpain) inhibitor Roscovitine, the neurotrophins contents and activities of ChaT and AchE were reverted, along with the improvement of neuron survival compared with BDE-153 treatment alone.	PD 150606	55-63	calpain 1	Rattus norvegicus	37-44
31091145-5	2019	This reduced Ca2+-stimulated mutant KCNN4 activity in HX red cells was associated with unchanged sensitivity to KCNN4 inhibitor senicapoc and KCNN4 activator Ca2+, with slightly elevated Ca2+ uptake and reduced PMCA activity, and with decreased KCNN4 activation by calpain inhibitor PD150606.	PD 150606	283-291	potassium calcium-activated channel subfamily N member 4	Homo sapiens	36-41
30807754-6	2019	The administration of calpain inhibitors (calpain inhibitor-IV, PD150606 and PD151746) showed that p-Akt and p-eNOS protein levels were correlated with the levels of LPS-induced myocardial calpain and caspase-3 activity.	PD 150606	64-72	AKT serine/threonine kinase 1	Rattus norvegicus	101-104
30807754-6	2019	The administration of calpain inhibitors (calpain inhibitor-IV, PD150606 and PD151746) showed that p-Akt and p-eNOS protein levels were correlated with the levels of LPS-induced myocardial calpain and caspase-3 activity.	PD 150606	64-72	nitric oxide synthase 3	Rattus norvegicus	111-115
30416776-10	2018	In an in vitro model of oxidative stress, H2O2 stimulation of H9c2 cardiomyoblasts induced calpain activation, CHOP expression, and cell death, all of which were prevented by the calpain inhibitor PD150606, as well as CHOP silencing.	PD 150606	197-205	DNA-damage inducible transcript 3	Mus musculus	111-115
30416776-10	2018	In an in vitro model of oxidative stress, H2O2 stimulation of H9c2 cardiomyoblasts induced calpain activation, CHOP expression, and cell death, all of which were prevented by the calpain inhibitor PD150606, as well as CHOP silencing.	PD 150606	197-205	DNA-damage inducible transcript 3	Mus musculus	218-222
32851835-6	2020	Furthermore, a pan-caspase inhibitor, z-VAD-fmk, and PD150606, a specific calpain inhibitor, both significantly suppressed the endoplasmic reticulum-targeted BNIP3-induced cell death.	PD 150606	53-61	BCL2 interacting protein 3	Homo sapiens	158-163
29112674-0	2018	Interleukin-10 and PD150606 modulate expression of AMPA receptor GluA1 and GluA2 subunits under hypoxic conditions.	PD 150606	19-27	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	65-70
29112674-0	2018	Interleukin-10 and PD150606 modulate expression of AMPA receptor GluA1 and GluA2 subunits under hypoxic conditions.	PD 150606	19-27	glutamate ionotropic receptor AMPA type subunit 2	Rattus norvegicus	75-80
28559121-7	2017	Calpain inhibitor PD150606 or p25/Cdk5 inhibitor Roscovitine relieved neuronal apoptosis mainly via inhibiting the p25/Cdk5 activation.	PD 150606	18-26	calpain 1	Rattus norvegicus	0-7
28559121-7	2017	Calpain inhibitor PD150606 or p25/Cdk5 inhibitor Roscovitine relieved neuronal apoptosis mainly via inhibiting the p25/Cdk5 activation.	PD 150606	18-26	lipocalin 2	Rattus norvegicus	115-118
28559121-7	2017	Calpain inhibitor PD150606 or p25/Cdk5 inhibitor Roscovitine relieved neuronal apoptosis mainly via inhibiting the p25/Cdk5 activation.	PD 150606	18-26	cyclin-dependent kinase 5	Rattus norvegicus	119-123
28419922-8	2017	PD150606 significantly attenuated the up-regulation of active caspase-3 and the apoptosis induced by Cd.	PD 150606	0-8	caspase 3	Rattus norvegicus	62-71
26091952-0	2015	PD150606 protects against ischemia/reperfusion injury by preventing mu-calpain-induced mitochondrial apoptosis.	PD 150606	0-8	calpain 1	Mus musculus	68-78
25820375-6	2015	Calpain inhibitor, PD150606, effectively inhibited Ang II-induced apoptosis of hypertrophied cardiomyocytes.	PD 150606	19-27	angiotensinogen	Rattus norvegicus	51-57
28366808-6	2017	A prior intracochlear injection of the calpain inhibitor PD150606 significantly abolished this noise-induced hearing loss on days 5 and 7 post exposure.	PD 150606	57-65	calpastatin	Mus musculus	39-56
28078280-8	2016	The effect of emodin on calpain 1 activity, the expression levels of the active fragments of caspases 12 and 3, neutrophil apoptosis, and SIRS scores were attenuated by PD150606 (an inhibitor of calpain).	PD 150606	169-177	calpain 1	Rattus norvegicus	24-33
28078280-8	2016	The effect of emodin on calpain 1 activity, the expression levels of the active fragments of caspases 12 and 3, neutrophil apoptosis, and SIRS scores were attenuated by PD150606 (an inhibitor of calpain).	PD 150606	169-177	caspase 12	Rattus norvegicus	93-110
26091952-11	2015	Our results suggest that PD150606 may protect against I/R injury via preventing mu-calpain-induced mitochondrial apoptosis.	PD 150606	25-33	calpain 1	Mus musculus	80-90
25813209-2	2015	Herein, we selected muscle precursor C2C12 myoblasts as representative cells to test effect of calpain inhibitor 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD150606) on LPS induced inflammation and apoptosis.	PD 150606	113-161	toll-like receptor 4	Mus musculus	176-179
25196359-5	2014	RESULTS: PD150606 inhibits both full-length calpain-2 and the protease core of calpain-1 with an apparent noncompetitive kinetic model.	PD 150606	9-17	calpain 2	Homo sapiens	44-53
25874633-0	2015	Calpain inhibitor PD150606 attenuates glutamate induced spiral ganglion neuron apoptosis through apoptosis inducing factor pathway in vitro.	PD 150606	18-26	apoptosis inducing factor mitochondria associated 1	Homo sapiens	97-122
25874633-2	2015	And verify whether PD150606, a calpain inhibitor could prevent apoptosis by inhibiting cleaving and releasing AIF in mitochondrion.	PD 150606	19-27	apoptosis inducing factor mitochondria associated 1	Homo sapiens	110-113
26269309-5	2015	While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group.	PD 150606	31-39	calpain 1	Homo sapiens	86-95
26269309-5	2015	While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group.	PD 150606	31-39	cadherin 1	Homo sapiens	172-177
26269309-5	2015	While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group.	PD 150606	31-39	transforming growth factor beta 1	Homo sapiens	277-286
26269309-5	2015	While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group.	PD 150606	225-233	cadherin 1	Homo sapiens	172-177
26269309-5	2015	While, after calpain inhibitor PD150606 was added, the protein and mRNA expression of Calpain-1 and alpha-SMA was markedly decreased and the protein and mRNA expression of E-cad was significantly increased in the TGF-betal + PD150606 group, but there was no difference between TGF-beta1 + PD150606 group and control group.	PD 150606	225-233	cadherin 1	Homo sapiens	172-177
26269309-6	2015	But with Calpain inhibitor PD150606 alone, the expression of Calpain-1,E-cad and alpha-SMA was no difference with the control group.	PD 150606	27-35	calpain 1	Homo sapiens	61-70
26269309-6	2015	But with Calpain inhibitor PD150606 alone, the expression of Calpain-1,E-cad and alpha-SMA was no difference with the control group.	PD 150606	27-35	cadherin 1	Homo sapiens	71-76
26183016-9	2015	The calpain inhibitor PD150606 and the p38-MAPK inhibitor SB203580 inhibited apoptosis induced by TNF-alpha.	PD 150606	22-30	tumor necrosis factor	Rattus norvegicus	98-107
25196359-5	2014	RESULTS: PD150606 inhibits both full-length calpain-2 and the protease core of calpain-1 with an apparent noncompetitive kinetic model.	PD 150606	9-17	calpain 1	Homo sapiens	79-88
25196359-7	2014	CONCLUSIONS: PD150606 cannot inhibit cleavage by calpain-2 of small substrates via binding to the penta-EF-hand domain.	PD 150606	13-21	calpain 2	Homo sapiens	49-58
19798049-6	2010	Cell death was due to activation of calpain as well as caspases-7 and -3 and it was abolished by the combination of calpain (PD150606) and pancaspase (benzyloxycarbonyl-Val-Ala-Asp-fluormethyl ketone, z-VAD-fmk) inhibitors.	PD 150606	125-133	caspase 7	Homo sapiens	55-72
23425388-8	2013	The administration of calpain inhibitors (calpain inhibitor-SH or PD150606) prevented the LPS-induced degradation of myocardial Hsp90/p-Akt protein and its expression in cardiomyocytes in addition to inhibiting myocardial caspase-3 activation and apoptosis.	PD 150606	66-74	heat shock protein 86, pseudogene 2	Mus musculus	128-133
23425388-8	2013	The administration of calpain inhibitors (calpain inhibitor-SH or PD150606) prevented the LPS-induced degradation of myocardial Hsp90/p-Akt protein and its expression in cardiomyocytes in addition to inhibiting myocardial caspase-3 activation and apoptosis.	PD 150606	66-74	thymoma viral proto-oncogene 1	Mus musculus	136-139
23425388-8	2013	The administration of calpain inhibitors (calpain inhibitor-SH or PD150606) prevented the LPS-induced degradation of myocardial Hsp90/p-Akt protein and its expression in cardiomyocytes in addition to inhibiting myocardial caspase-3 activation and apoptosis.	PD 150606	66-74	caspase 3	Mus musculus	222-231
22366408-8	2012	Treatment of Emu-myc lymphoma cells with the calpain inhibitors PD150606 or calpain inhibitor III induced caspase-3-dependent apoptosis in vitro.	PD 150606	64-72	caspase 3	Homo sapiens	106-115
22575511-5	2012	Four calpain inhibitors (calpain inhibitor III, ALLM, ALLN, and PD-150606) were tested for their ability to inhibit MMP-2 in comparison to the selective MMP inhibitor ONO-4817.	PD 150606	64-73	matrix metallopeptidase 2	Homo sapiens	116-121
22575511-7	2012	When assessed by the troponin I proteolysis assay, both ALLN and PD-150606, but neither ALLM nor calpain inhibitor III (at 20 muM), significantly inhibited MMP-2 activity.	PD 150606	65-74	matrix metallopeptidase 2	Homo sapiens	156-161
22575511-8	2012	Using a fluorogenic MMP substrate peptide OmniMMP in a kinetic assay the rank order of IC(50) values against MMP-2 were: PD-150606<ALLN<calpain inhibitor III <<< ALLM.	PD 150606	121-130	matrix metallopeptidase 2	Homo sapiens	109-114
22575511-9	2012	These experiments show that the calpain inhibitors PD-150606 and ALLN have significant additional pharmacological activity as MMP-2 inhibitors.	PD 150606	51-60	matrix metallopeptidase 2	Homo sapiens	126-131
21414921-7	2011	Pretreatment with 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD150606), a broad cell-permeable calpain inhibitor, and two additional calpain inhibitors diminished Bax activation, inhibited its translocation to mitochondria, and attenuated all apoptotic events resulting from excitotoxic insults to rat oligodendrocytes.	PD 150606	18-66	BCL2 associated X, apoptosis regulator	Rattus norvegicus	170-173
20945043-7	2010	Cardiac TnI degradation was significantly increased after tail-suspension (P<0.01), but cTnI degradation in both SUS and control groups was significantly inhibited by a non-specific inhibitor of calpain, PD150606 (P<0.01).	PD 150606	207-215	troponin I3, cardiac type	Rattus norvegicus	91-95
24553345-4	2014	DeltaPK induces calpain activation in both melanoma and breast cancer 3D cultures as determined by the loss of the p28 regulatory subunit, and 3D growth is restored by treatment with the calpain inhibitor PD150606.	PD 150606	205-213	golgi SNAP receptor complex member 1	Homo sapiens	115-118
24553345-7	2014	PD150606 restores expression of p62/SQSTM1 in DeltaPK-infected melanoma cultures, suggesting that calpain activation induces anti-tumor activity through p62/SQSTM1 clearance.	PD 150606	0-8	sequestosome 1	Homo sapiens	32-35
24553345-7	2014	PD150606 restores expression of p62/SQSTM1 in DeltaPK-infected melanoma cultures, suggesting that calpain activation induces anti-tumor activity through p62/SQSTM1 clearance.	PD 150606	0-8	sequestosome 1	Homo sapiens	36-42
24553345-7	2014	PD150606 restores expression of p62/SQSTM1 in DeltaPK-infected melanoma cultures, suggesting that calpain activation induces anti-tumor activity through p62/SQSTM1 clearance.	PD 150606	0-8	sequestosome 1	Homo sapiens	153-156
24553345-7	2014	PD150606 restores expression of p62/SQSTM1 in DeltaPK-infected melanoma cultures, suggesting that calpain activation induces anti-tumor activity through p62/SQSTM1 clearance.	PD 150606	0-8	sequestosome 1	Homo sapiens	157-163
24441549-8	2014	Administration of the calpain inhibitors calpain inhibitor SH and PD-150606 prevented the LPS-induced degradation of myocardial IkappaBalpha, NF-kappaB activation, and TNF-alpha expression and ultimately improved myocardial function.	PD 150606	66-75	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	128-140
24441549-8	2014	Administration of the calpain inhibitors calpain inhibitor SH and PD-150606 prevented the LPS-induced degradation of myocardial IkappaBalpha, NF-kappaB activation, and TNF-alpha expression and ultimately improved myocardial function.	PD 150606	66-75	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	142-151
24441549-8	2014	Administration of the calpain inhibitors calpain inhibitor SH and PD-150606 prevented the LPS-induced degradation of myocardial IkappaBalpha, NF-kappaB activation, and TNF-alpha expression and ultimately improved myocardial function.	PD 150606	66-75	tumor necrosis factor	Mus musculus	168-177
21092655-7	2010	Both calpain inhibitor-III and PD150606 significantly attenuated the increase of caspase-3 activity.	PD 150606	31-39	caspase 3	Mus musculus	81-90
18647593-2	2008	Calpain inhibitors (PD150606 and N-acetyl-Leu-Leu-Nle-CHO) prevented spontaneous neutrophil apoptosis and degradation of Mcl-1 and XIAP, and the effects of calpain inhibitors on neutrophils were resistant to cycloheximide.	PD 150606	20-28	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	121-126
19909740-4	2010	Inhibition of CAPN9 expression in MCF7/CEACAM1-4S cells by RNAi or by calpeptin or PD150606 inhibited lumen formation.	PD 150606	83-91	calpain 9	Homo sapiens	14-19
18647593-2	2008	Calpain inhibitors (PD150606 and N-acetyl-Leu-Leu-Nle-CHO) prevented spontaneous neutrophil apoptosis and degradation of Mcl-1 and XIAP, and the effects of calpain inhibitors on neutrophils were resistant to cycloheximide.	PD 150606	20-28	X-linked inhibitor of apoptosis	Homo sapiens	131-135
18544539-7	2008	HL60 cells knocked down for c-Myc expression exhibited reduced calpain activity and decreased sensitivity to PD150606 but not epoxomycin.	PD 150606	109-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	28-33
18214855-5	2008	Calpeptin and PD150606, specific inhibitors of calpain, blocked Bid activation completely; however, cytochrome c release was delayed by more than 2 hr, which was associated with the delay of caspase-3 activation and cell death.	PD 150606	14-22	BH3 interacting domain death agonist	Homo sapiens	64-67
18214855-5	2008	Calpeptin and PD150606, specific inhibitors of calpain, blocked Bid activation completely; however, cytochrome c release was delayed by more than 2 hr, which was associated with the delay of caspase-3 activation and cell death.	PD 150606	14-22	caspase 3	Homo sapiens	191-200
16891617-6	2006	Treatment of the human metastatic breast carcinoma cell line MT-2 with MDL28170 and 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD 150606), two calpain-selective inhibitors, completely abolished the TCDD-induced transactivation of AhR as assessed by transcription of CYP1A1 gene.	PD 150606	84-132	aryl hydrocarbon receptor	Homo sapiens	237-240
17567592-5	2007	In contrast, pAP-induced caspase-12 cleavage products were significantly decreased with PD150606 pretreatment, demonstrating that caspase-12 activation was calpain dependent.	PD 150606	88-96	caspase 12	Rattus norvegicus	25-35
17567592-5	2007	In contrast, pAP-induced caspase-12 cleavage products were significantly decreased with PD150606 pretreatment, demonstrating that caspase-12 activation was calpain dependent.	PD 150606	88-96	caspase 12	Rattus norvegicus	130-140
16891617-6	2006	Treatment of the human metastatic breast carcinoma cell line MT-2 with MDL28170 and 3-(4-iodophenyl)-2-mercapto-(Z)-2-propenoic acid (PD 150606), two calpain-selective inhibitors, completely abolished the TCDD-induced transactivation of AhR as assessed by transcription of CYP1A1 gene.	PD 150606	84-132	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	273-279
10477146-7	1999	The calpain inhibitor (2)-3-(4-iodophenyl)-2-mercapto-2-propenoic acid (PD150606) also inhibited the hypoxia-induced increase in caspase activity in proximal tubules, but did not inhibit the activity of purified caspase 1 in vitro.	PD 150606	72-80	caspase 1	Rattus norvegicus	212-221
16920763-3	2006	The calpain inhibitor, PD150606, significantly reduced the RCT and TUN-induced cell death in the renal cell line LLC-PK1, but not death induced by THAPS.	PD 150606	23-31	prokineticin 1	Homo sapiens	117-120
15451377-5	2004	Intracerebroventricularly applied PD150606 inhibited the CA1 layer shrinkage after common carotid ligation.	PD 150606	34-42	carbonic anhydrase 1	Rattus norvegicus	57-60
15041468-3	2004	To extend and complement these findings, we tested the effect of a specific inhibitor, PD 150606, on granulocyte-macrophage-colony stimulating factor (GM-CSF)-stimulated human TF-1 cells by flow cytometry following single- and double labelling by propidium iodide and bromodeoxyuridine.	PD 150606	87-96	colony stimulating factor 2	Homo sapiens	101-149
15041468-3	2004	To extend and complement these findings, we tested the effect of a specific inhibitor, PD 150606, on granulocyte-macrophage-colony stimulating factor (GM-CSF)-stimulated human TF-1 cells by flow cytometry following single- and double labelling by propidium iodide and bromodeoxyuridine.	PD 150606	87-96	colony stimulating factor 2	Homo sapiens	151-157
14527821-6	2003	Caspase-3 was also activated by simvastatin after 12 h. Verapamil and PD150606, a cell-permeable selective calpain inhibitor, significantly inhibited simvastatin-induced augmentation of calpain activity and blocked caspase-3 activation, respectively.	PD 150606	70-78	caspase 3	Rattus norvegicus	0-9
14527821-6	2003	Caspase-3 was also activated by simvastatin after 12 h. Verapamil and PD150606, a cell-permeable selective calpain inhibitor, significantly inhibited simvastatin-induced augmentation of calpain activity and blocked caspase-3 activation, respectively.	PD 150606	70-78	caspase 3	Rattus norvegicus	215-224
12124441-6	2002	In contrast, inhibition of either caspase-3 by DEVD-CHO or calpain by PD 150606 protected cells from excitotoxicity.	PD 150606	70-79	caspase 3	Rattus norvegicus	34-43
35126174-9	2021	Furthermore, similar results were observed in macrophages treated with calpain1 inhibitor PD150606.	PD 150606	90-98	calpain 1	Homo sapiens	71-79