PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
31854974-7	2020	A sensitive bioassay for acetylcholinesterase (AChE) was established based on the excellent oxidase-like activity of C-CoCu-HNC, offering a linear detection range from 0.0001 to 1 mU/mL with an ultralow detection limit of 0.1 mU/L.	1-hydroxy-11-norcadinan-5-en-4-one	117-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	25-45
34314061-8	2021	VGLL4 knockdown attenuated CNH-induced PH and pulmonary artery remodeling by blunting signal transducer and activator of transcription 3 (STAT3) signaling; conversely, VGLL4 overexpression exacerbated the development of PH.	1-hydroxy-11-norcadinan-5-en-4-one	27-30	vestigial like family member 4	Mus musculus	0-5
34314061-8	2021	VGLL4 knockdown attenuated CNH-induced PH and pulmonary artery remodeling by blunting signal transducer and activator of transcription 3 (STAT3) signaling; conversely, VGLL4 overexpression exacerbated the development of PH.	1-hydroxy-11-norcadinan-5-en-4-one	27-30	signal transducer and activator of transcription 3	Mus musculus	86-136
34314061-8	2021	VGLL4 knockdown attenuated CNH-induced PH and pulmonary artery remodeling by blunting signal transducer and activator of transcription 3 (STAT3) signaling; conversely, VGLL4 overexpression exacerbated the development of PH.	1-hydroxy-11-norcadinan-5-en-4-one	27-30	signal transducer and activator of transcription 3	Mus musculus	138-143
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	vestigial like family member 4	Mus musculus	32-37
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	vestigial like family member 4	Mus musculus	79-84
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	signal transducer and activator of transcription 3	Mus musculus	97-102
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	signal transducer and activator of transcription 3	Mus musculus	149-154
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	signal transducer and activator of transcription 3	Mus musculus	155-160
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	vestigial like family member 4	Mus musculus	32-37
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	vestigial like family member 4	Mus musculus	79-84
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	signal transducer and activator of transcription 3	Mus musculus	97-102
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	signal transducer and activator of transcription 3	Mus musculus	149-154
34314061-9	2021	CNH enhanced the acetylation of VGLL4 and increased the interaction of ac-H3K9/VGLL4 and ac-H3K9/STAT3 in the lung tissues, and levels of ac-H3K9, p-STAT3/STAT3, and proliferation-associated protein levels were markedly up-regulated, whereas apoptosis-related protein levels were significantly downregulated, in the lung tissues of mice with CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	342-345	signal transducer and activator of transcription 3	Mus musculus	155-160
34314061-10	2021	Notably, abrogation of VGLL4 acetylation reversed CNH-induced PH and pulmonary artery remodeling and suppressed STAT3 signaling.	1-hydroxy-11-norcadinan-5-en-4-one	50-53	vestigial like family member 4	Mus musculus	23-28
34314061-10	2021	Notably, abrogation of VGLL4 acetylation reversed CNH-induced PH and pulmonary artery remodeling and suppressed STAT3 signaling.	1-hydroxy-11-norcadinan-5-en-4-one	50-53	signal transducer and activator of transcription 3	Mus musculus	112-117
34314061-11	2021	Finally, STAT3 knockdown alleviated CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	36-39	signal transducer and activator of transcription 3	Mus musculus	9-14
34314061-12	2021	In conclusion, VGLL4 acetylation upregulation could contribute to CNH-induced PH and pulmonary artery remodeling via STAT3 signaling, and abrogation of VGLL4 acetylation reversed CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	66-69	vestigial like family member 4	Mus musculus	15-20
34314061-12	2021	In conclusion, VGLL4 acetylation upregulation could contribute to CNH-induced PH and pulmonary artery remodeling via STAT3 signaling, and abrogation of VGLL4 acetylation reversed CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	66-69	signal transducer and activator of transcription 3	Mus musculus	117-122
34314061-12	2021	In conclusion, VGLL4 acetylation upregulation could contribute to CNH-induced PH and pulmonary artery remodeling via STAT3 signaling, and abrogation of VGLL4 acetylation reversed CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	179-182	vestigial like family member 4	Mus musculus	15-20
34314061-12	2021	In conclusion, VGLL4 acetylation upregulation could contribute to CNH-induced PH and pulmonary artery remodeling via STAT3 signaling, and abrogation of VGLL4 acetylation reversed CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	179-182	vestigial like family member 4	Mus musculus	152-157
34314061-13	2021	Pharmacological or genetic deletion of VGLL4 might be a potential target for therapeutic interventions in CNH-induced PH.	1-hydroxy-11-norcadinan-5-en-4-one	106-109	vestigial like family member 4	Mus musculus	39-44
32048865-1	2020	The problem of computing the rooted subtree prune and regraft (rSPR) distance of two phylogenetic trees is computationally hard and so is the problem of computing the hybridization number of two phylogenetic trees (denoted by Hybridization Number Computation [HNC]).	1-hydroxy-11-norcadinan-5-en-4-one	260-263	sepiapterin reductase	Rattus norvegicus	63-67
31854974-7	2020	A sensitive bioassay for acetylcholinesterase (AChE) was established based on the excellent oxidase-like activity of C-CoCu-HNC, offering a linear detection range from 0.0001 to 1 mU/mL with an ultralow detection limit of 0.1 mU/L.	1-hydroxy-11-norcadinan-5-en-4-one	117-127	acetylcholinesterase (Cartwright blood group)	Homo sapiens	47-51
31854974-8	2020	As the PMS activator, the C-CoCu-HNC was applied for targeted organic pollutant (rhodamine B, RhB) degradation.	1-hydroxy-11-norcadinan-5-en-4-one	26-36	proline rich protein BstNI subfamily 1	Homo sapiens	7-10
31854974-12	2020	These changes facilitated the adsorption of O2/PMS on the C-CoCu-HNC surface for dissociation.	1-hydroxy-11-norcadinan-5-en-4-one	58-68	immunoglobulin kappa variable 1D-39	Homo sapiens	44-50
28567570-8	2018	In addition to that, CNH markedly enhanced the expression of catalase and aldehyde dehydrogenase-2 in both strains, and decreased the expression of Cu/Zn superoxide dismutase in SHR.	1-hydroxy-11-norcadinan-5-en-4-one	21-24	catalase	Rattus norvegicus	61-69
28567570-8	2018	In addition to that, CNH markedly enhanced the expression of catalase and aldehyde dehydrogenase-2 in both strains, and decreased the expression of Cu/Zn superoxide dismutase in SHR.	1-hydroxy-11-norcadinan-5-en-4-one	21-24	aldehyde dehydrogenase 1 family, member A1	Rattus norvegicus	74-98
28567570-9	2018	Adaptation to CNH intensified oxidative stress to a similar extent in both strains and elevated the IL-10/TNF-alpha ratio in SHR-mtBN only.	1-hydroxy-11-norcadinan-5-en-4-one	14-17	interleukin 10	Rattus norvegicus	100-105
28567570-9	2018	Adaptation to CNH intensified oxidative stress to a similar extent in both strains and elevated the IL-10/TNF-alpha ratio in SHR-mtBN only.	1-hydroxy-11-norcadinan-5-en-4-one	14-17	tumor necrosis factor	Rattus norvegicus	106-115
29676955-11	2018	Pleiotropic effects of upregulated Akt2 along with HK translocation to mitochondria and mitochondria-associated membranes can potentially contribute to a stronger CNH-afforded cardioprotection in SHR-mtBN compared with progenitor SHR.	1-hydroxy-11-norcadinan-5-en-4-one	163-166	AKT serine/threonine kinase 2	Rattus norvegicus	35-39
28290047-5	2017	The CNH resulted in increased levels of HK1 and HK2 proteins and the total HK activity after ischemia compared to corresponding normoxic group.	1-hydroxy-11-norcadinan-5-en-4-one	4-7	hexokinase 1	Rattus norvegicus	40-43
32264275-5	2017	The efficacy and specificity of the D2B-cisplatin-CNH conjugate to selectively target and kill PSMA+ prostate cancer cells have been demonstrated in comparison with other derivatives.	1-hydroxy-11-norcadinan-5-en-4-one	50-53	folate hydrolase 1	Homo sapiens	95-99
29680708-2	2018	This study aims to investigate whether SIRT1 is involved in the anxiolytic effect of apelin-13 in CNH-treated mice, and to illustrate the potential underlying mechanism.	1-hydroxy-11-norcadinan-5-en-4-one	98-101	sirtuin 1	Mus musculus	39-44
29680708-3	2018	We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1.	1-hydroxy-11-norcadinan-5-en-4-one	150-153	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	94-97
29680708-3	2018	We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1.	1-hydroxy-11-norcadinan-5-en-4-one	150-153	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	204-213
29680708-3	2018	We showed that apelin-13 treatment reversed a decrease in SIRT1 and an increase in acetylated p65 (lysine 310) proteins" expression in hippocampus of CNH-treated mice, indicating that apelin-13 inhibited NF-kappaB signaling pathway by activating SIRT1.	1-hydroxy-11-norcadinan-5-en-4-one	150-153	sirtuin 1	Mus musculus	246-251
29680708-4	2018	Behaviorally, apelin-13 ameliorated CNH-induced anxiety-like behavior, EX-527 blocked the beneficial effect of apelin-13, and the anxiogenic effect of CNH was attenuated by resveratrol pretreatment, suggesting that SIRT1 was involved in the effect of apelin-13 against CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	151-154	sirtuin 1	Mus musculus	215-220
29680708-4	2018	Behaviorally, apelin-13 ameliorated CNH-induced anxiety-like behavior, EX-527 blocked the beneficial effect of apelin-13, and the anxiogenic effect of CNH was attenuated by resveratrol pretreatment, suggesting that SIRT1 was involved in the effect of apelin-13 against CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	151-154	sirtuin 1	Mus musculus	215-220
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	59-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	59-62	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	136-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	21-30
29680708-6	2018	Finally, blockade of NF-kappaB activity by PDTC diminished CNH-induced anxiety-like behavior, indicating that NF-kappaB was involved in CNH-induced anxiety-like behavior in mice.	1-hydroxy-11-norcadinan-5-en-4-one	136-139	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	110-119
29680708-7	2018	In conclusion, this study provides the first evidence that SIRT1 mediates the anxiolytic effect of apelin-13 in CNH-treated mice through the inhibition of NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	112-115	sirtuin 1	Mus musculus	59-64
29680708-7	2018	In conclusion, this study provides the first evidence that SIRT1 mediates the anxiolytic effect of apelin-13 in CNH-treated mice through the inhibition of NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	112-115	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	155-164
29680708-8	2018	These results imply that dysfunction of the apelin-SIRT1-NF-kappaB axis in hippocampus represents a potential mechanism that results in the induction of neuroinflammation and reduction in neuroprotection, thus induces anxiety-like behavior in CNH-treated mice.	1-hydroxy-11-norcadinan-5-en-4-one	243-246	sirtuin 1	Mus musculus	51-56
29680708-8	2018	These results imply that dysfunction of the apelin-SIRT1-NF-kappaB axis in hippocampus represents a potential mechanism that results in the induction of neuroinflammation and reduction in neuroprotection, thus induces anxiety-like behavior in CNH-treated mice.	1-hydroxy-11-norcadinan-5-en-4-one	243-246	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
28290047-5	2017	The CNH resulted in increased levels of HK1 and HK2 proteins and the total HK activity after ischemia compared to corresponding normoxic group.	1-hydroxy-11-norcadinan-5-en-4-one	4-7	hexokinase 2	Rattus norvegicus	48-51
26972056-4	2016	CNH induced a significant increase of anxiety- like behavior and inflammation responses, which were ameliorated by NF-kappaB inhibitor, PDTC pretreatment, suggesting that the anxiogenic effect induced by inflammation is through NF-kappaB activation.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	115-124
26972056-4	2016	CNH induced a significant increase of anxiety- like behavior and inflammation responses, which were ameliorated by NF-kappaB inhibitor, PDTC pretreatment, suggesting that the anxiogenic effect induced by inflammation is through NF-kappaB activation.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	228-237
26972056-5	2016	CNH treatment significantly increased nucleus translocation of p65 and p105 in hippocampus, which was suppressed by PDTC pretreatment.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	synaptotagmin 1	Rattus norvegicus	63-66
26972056-5	2016	CNH treatment significantly increased nucleus translocation of p65 and p105 in hippocampus, which was suppressed by PDTC pretreatment.	1-hydroxy-11-norcadinan-5-en-4-one	0-3	nucleoporin 107	Rattus norvegicus	71-75
26972056-6	2016	In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	13-16	induction of brown adipocytes 1	Mus musculus	51-56
26972056-6	2016	In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	13-16	nitric oxide synthase 2, inducible	Mus musculus	58-62
26972056-6	2016	In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	13-16	cytochrome c oxidase II, mitochondrial	Mus musculus	64-69
26972056-6	2016	In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	13-16	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	205-214
26972056-6	2016	In addition, CNH treatment significantly increased Iba-1, iNOS, COX-2, and p-PKA in hippocampus, which were blocked by PDTC pretreatment, suggesting CNH may activate microglia cells in hippocampus through NF-kappaB pathway.	1-hydroxy-11-norcadinan-5-en-4-one	149-152	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	205-214
28065733-8	2017	We found that CNH treatment decreased APJ but increased Iba-1 proteins expression, as well as nucleus translocation of p50 and p65 in the hippocampus, which were reversed by apelin-13 treatment.	1-hydroxy-11-norcadinan-5-en-4-one	14-17	apelin receptor	Mus musculus	38-41
28065733-8	2017	We found that CNH treatment decreased APJ but increased Iba-1 proteins expression, as well as nucleus translocation of p50 and p65 in the hippocampus, which were reversed by apelin-13 treatment.	1-hydroxy-11-norcadinan-5-en-4-one	14-17	induction of brown adipocytes 1	Mus musculus	56-61
28065733-8	2017	We found that CNH treatment decreased APJ but increased Iba-1 proteins expression, as well as nucleus translocation of p50 and p65 in the hippocampus, which were reversed by apelin-13 treatment.	1-hydroxy-11-norcadinan-5-en-4-one	14-17	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	127-130
28065733-8	2017	We found that CNH treatment decreased APJ but increased Iba-1 proteins expression, as well as nucleus translocation of p50 and p65 in the hippocampus, which were reversed by apelin-13 treatment.	1-hydroxy-11-norcadinan-5-en-4-one	14-17	apelin	Mus musculus	174-180
28065733-9	2017	In addition, apelin-13 treatment ameliorated CNH-induced anxiety-like behavior in mice, suggesting anxiogenic effect of apelin-13 might be mediated by an inhibition of NF-kappaB activation in microglial of the hippocampus.	1-hydroxy-11-norcadinan-5-en-4-one	45-48	apelin	Mus musculus	13-19
28065733-10	2017	Furthermore, apelin-13 treatment reversed p-CAMKII decrease in the hippocampus under CNH treatment.	1-hydroxy-11-norcadinan-5-en-4-one	85-88	apelin	Mus musculus	13-19
28065733-12	2017	Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity.	1-hydroxy-11-norcadinan-5-en-4-one	33-36	apelin receptor	Rattus norvegicus	57-60
28065733-12	2017	Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity.	1-hydroxy-11-norcadinan-5-en-4-one	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96
28065733-12	2017	Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity.	1-hydroxy-11-norcadinan-5-en-4-one	33-36	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	164-173
28065733-12	2017	Finally, we found that rats with CNH treatment decreased APJ expression while enhanced NF-kappaB activation in the hippocampus, providing additional evidences that NF-kappaB activation in hippocampus in CNH-induced anxiety-like behavior in rats we reported previously might be associated with an inhibition of APJ activity.	1-hydroxy-11-norcadinan-5-en-4-one	33-36	apelin receptor	Rattus norvegicus	310-313
28065733-13	2017	In conclusion, the present results illustrated that inhibition of APJ and promotion of NF-kappaB activation in the microglial of hippocampus might be involved in anxiogenic effect in CNH-exposed mice, and apelin-13 ameliorates CNH-induced anxiety-like behavior might be associated with an inhibition of NF-kappaB activation.	1-hydroxy-11-norcadinan-5-en-4-one	183-186	apelin receptor	Mus musculus	66-69
28065733-13	2017	In conclusion, the present results illustrated that inhibition of APJ and promotion of NF-kappaB activation in the microglial of hippocampus might be involved in anxiogenic effect in CNH-exposed mice, and apelin-13 ameliorates CNH-induced anxiety-like behavior might be associated with an inhibition of NF-kappaB activation.	1-hydroxy-11-norcadinan-5-en-4-one	183-186	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	87-96