PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
34648994-0	2021	Chitosan-tripolyphosphate nanoparticles-mediated co-delivery of MTHFD1L shRNA and 5-aminolevulinic acid for combination photodynamic-gene therapy in oral cancer.	tpp	0-25	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	64-71
34648994-3	2021	METHODS: First, a nano-co-delivery of chitosan/tripolyphosphate (CS-TPP) was synthesized and characterized combining 5-aminolevulinic acid photodynamic therapy (ALA-PDT) with methylenetetrahydrofolate dehydrogenase 1-like (MTHFD1L) shRNA.	tpp	65-71	methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like	Homo sapiens	223-230
34648994-5	2021	The efficacy of CS-TPP-(shMTHFD1L-ALA)-PDT in inducing apoptosis and in generating of reactive oxygen species (ROS) in vitro was then assessed by Annexin V-PI and DCFH-DA assays respectively.	tpp	16-22	annexin A5	Homo sapiens	146-155
30465996-1	2019	We have successfully encapsulated two proteins, bovine serum albumin (BSA) and p53, in chitosan-tripolyphosphate (TPP) nanoparticles at various pH values from 5.5 to 6.5 and delivered the particles to human melanoma cells.	tpp	114-117	tumor protein p53	Homo sapiens	79-82
30465996-5	2019	The method we describe appears to be a general method for delivery of proteins to cells using chitosan-TPP nanoparticles as a drug delivery system, since structurally unrelated proteins such as BSA and p53 with different isoelectrical points can be encapsulated in the chitosan-TPP nanoparticles and be effectively internalized by the cells.	tpp	103-106	tumor protein p53	Homo sapiens	202-205
30465996-5	2019	The method we describe appears to be a general method for delivery of proteins to cells using chitosan-TPP nanoparticles as a drug delivery system, since structurally unrelated proteins such as BSA and p53 with different isoelectrical points can be encapsulated in the chitosan-TPP nanoparticles and be effectively internalized by the cells.	tpp	278-281	tumor protein p53	Homo sapiens	202-205
24926362-0	2014	Effect of erythropoietin loading chitosan-tripolyphosphate nanoparticles on an IgA nephropathy rat model.	tpp	33-58	erythropoietin	Rattus norvegicus	10-24
24926362-1	2014	The aim of the present study was to investigate the effect of erythropoietin (EPO) loading chitosan-tripolyphosphate (CS-TPP) nanoparticles on an immunoglobulin A nephropathy (IgAN) rat model.	tpp	91-116	erythropoietin	Rattus norvegicus	62-76
24926362-1	2014	The aim of the present study was to investigate the effect of erythropoietin (EPO) loading chitosan-tripolyphosphate (CS-TPP) nanoparticles on an immunoglobulin A nephropathy (IgAN) rat model.	tpp	91-116	erythropoietin	Rattus norvegicus	78-81
24926362-1	2014	The aim of the present study was to investigate the effect of erythropoietin (EPO) loading chitosan-tripolyphosphate (CS-TPP) nanoparticles on an immunoglobulin A nephropathy (IgAN) rat model.	tpp	91-116	IGAN1	Homo sapiens	176-180
24926362-1	2014	The aim of the present study was to investigate the effect of erythropoietin (EPO) loading chitosan-tripolyphosphate (CS-TPP) nanoparticles on an immunoglobulin A nephropathy (IgAN) rat model.	tpp	118-124	erythropoietin	Rattus norvegicus	62-76
24926362-1	2014	The aim of the present study was to investigate the effect of erythropoietin (EPO) loading chitosan-tripolyphosphate (CS-TPP) nanoparticles on an immunoglobulin A nephropathy (IgAN) rat model.	tpp	118-124	erythropoietin	Rattus norvegicus	78-81
24926362-3	2014	The IgAN rat models were randomly divided into three groups: the CS-TPP-EPO group, CS-TPP group and EPO group.	tpp	65-71	erythropoietin	Rattus norvegicus	72-75
24926362-7	2014	The levels of BUN and Cr in the CS-TPP-EPO group were significantly lower compared with the control group (P<0.05); however, the level of Hb in the CS-TPP-EPO group was higher compared with the other groups (P<0.05).	tpp	32-38	erythropoietin	Rattus norvegicus	39-42
24926362-8	2014	The changes in Hb, BUN and Cr in the CS-TPP-EPO group were maintained for less than one week following the end of the treatment with CS-TPP-EPO nanoparticles.	tpp	37-43	erythropoietin	Rattus norvegicus	44-47
24926362-8	2014	The changes in Hb, BUN and Cr in the CS-TPP-EPO group were maintained for less than one week following the end of the treatment with CS-TPP-EPO nanoparticles.	tpp	37-43	erythropoietin	Rattus norvegicus	140-143
24926362-9	2014	In conclusion, the CS-TPP-EPO nanoparticles had a lower toxicity compared with EPO and CS-TPP treatment.	tpp	19-25	erythropoietin	Rattus norvegicus	26-29
24926362-9	2014	In conclusion, the CS-TPP-EPO nanoparticles had a lower toxicity compared with EPO and CS-TPP treatment.	tpp	87-93	erythropoietin	Rattus norvegicus	26-29
24926362-10	2014	Furthermore, CS-TPP-EPO may improve the therapeutic effect in the IgAN model.	tpp	13-19	erythropoietin	Rattus norvegicus	20-23
24926362-10	2014	Furthermore, CS-TPP-EPO may improve the therapeutic effect in the IgAN model.	tpp	13-19	IGAN1	Homo sapiens	66-70
20044203-1	2010	Chitosan-tripolyphosphate (CTPP) beads were synthesized, characterized and were used for the adsorption of Pb(II) and Cu(II) ions from aqueous solution.	tpp	0-25	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-124
20044203-1	2010	Chitosan-tripolyphosphate (CTPP) beads were synthesized, characterized and were used for the adsorption of Pb(II) and Cu(II) ions from aqueous solution.	tpp	27-31	submaxillary gland androgen regulated protein 3B	Homo sapiens	107-124
20044203-8	2010	Infrared spectra were used to elucidate the mechanism of Pb(II) and Cu(II) ions adsorption onto CTPP beads.	tpp	96-100	submaxillary gland androgen regulated protein 3B	Homo sapiens	57-74
35622002-5	2022	Layer-by-layer coatings based on BMP-2-containing chitosan tripolyphosphate nanogel particles and negatively charged alginate showed a good sustainment of BMP-2 release from chemically modified polycaprolactone fiber mats.	tpp	50-75	bone morphogenetic protein 2	Homo sapiens	33-38
35622002-5	2022	Layer-by-layer coatings based on BMP-2-containing chitosan tripolyphosphate nanogel particles and negatively charged alginate showed a good sustainment of BMP-2 release from chemically modified polycaprolactone fiber mats.	tpp	50-75	bone morphogenetic protein 2	Homo sapiens	155-160
35563203-4	2022	In this work, we produced fluorescein-labeled chitosan-tripolyphosphate nanoparticles containing non-carboxylated GRP (ucGRP) (FCNG) via ionotropic gelation, increasing its bioavailability, stability, and anti-inflammatory potential.	tpp	46-71	upper zone of growth plate and cartilage matrix associated	Homo sapiens	114-117
29337488-0	2016	Optimization of Transforming Growth Factor-beta1 siRNA Loaded Chitosan-Tripolyphosphate Nanoparticles for the Treatment of Colorectal Cancer Hepatic Metastasis in a Mouse Model.	tpp	62-87	transforming growth factor, beta 1	Mus musculus	16-48