PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 30669116-9 2019 Gene expression was the most sensitive endpoint with significant increased tgfb1a, bdnf, and ap1s1 expression observed with PFHxA exposure. perfluorohexanoic acid 124-129 transforming growth factor, beta 1a Danio rerio 75-81 30669116-9 2019 Gene expression was the most sensitive endpoint with significant increased tgfb1a, bdnf, and ap1s1 expression observed with PFHxA exposure. perfluorohexanoic acid 124-129 adaptor related protein complex 1 subunit sigma 1 Danio rerio 93-98 28802206-10 2017 Significant interaction effects (p < 0.15) on CC16 levels were found between asthma and PFOS, PFOA, PFBS and PFHxA in all participants. perfluorohexanoic acid 112-117 secretoglobin family 1A member 1 Homo sapiens 49-53 28283292-7 2017 However, after 72 and 78h of exposure, induction of cyp1a expression was significantly lower when embryos were co-exposed to PCB126+PFOS+PFHxA when compared to PCB126-exposed embryos. perfluorohexanoic acid 137-142 cytochrome P450, family 1, subfamily A Danio rerio 52-57 28283292-8 2017 Significant upregulation of gpx1a occurred after exposure to PCB126+PFHxA and to PCB126+PFOS+PFHxA at 30 and 48 hpf. perfluorohexanoic acid 68-73 glutathione peroxidase 1a Danio rerio 28-33 28283292-8 2017 Significant upregulation of gpx1a occurred after exposure to PCB126+PFHxA and to PCB126+PFOS+PFHxA at 30 and 48 hpf. perfluorohexanoic acid 93-98 glutathione peroxidase 1a Danio rerio 28-33 28283292-9 2017 Besides, embryos appeared more sensitive to PCB126+PFOS+PFHxA at 78 hpf: acaa2 and osbpl1a were significantly downregulated; dnmt1 was significantly upregulated. perfluorohexanoic acid 56-61 acetyl-CoA acyltransferase 2 Danio rerio 73-78 28283292-9 2017 Besides, embryos appeared more sensitive to PCB126+PFOS+PFHxA at 78 hpf: acaa2 and osbpl1a were significantly downregulated; dnmt1 was significantly upregulated. perfluorohexanoic acid 56-61 oxysterol binding protein-like 1A Danio rerio 83-90 28283292-9 2017 Besides, embryos appeared more sensitive to PCB126+PFOS+PFHxA at 78 hpf: acaa2 and osbpl1a were significantly downregulated; dnmt1 was significantly upregulated. perfluorohexanoic acid 56-61 DNA (cytosine-5-)-methyltransferase 1 Danio rerio 125-130 26459765-8 2015 These results suggest that PFHxA and PFHpA are developmental toxicants and teratogens, with PFHpA producing more severe effects on liver and heart development through the induction of ERK and JNK phosphorylation. perfluorohexanoic acid 27-32 mitogen-activated protein kinase 1 L homeolog Xenopus laevis 184-187 26459765-8 2015 These results suggest that PFHxA and PFHpA are developmental toxicants and teratogens, with PFHpA producing more severe effects on liver and heart development through the induction of ERK and JNK phosphorylation. perfluorohexanoic acid 27-32 mitogen-activated protein kinase 8 L homeolog Xenopus laevis 192-195 22302310-3 2012 Our laboratory recently reported significant effects of perfluorohexane sulfonate (PFHxS) and perfluorohexanoate (PFHxA) on messenger RNA (mRNA) levels of thyroid hormone (TH)-responsive genes in chicken embryonic neuronal cells. perfluorohexanoic acid 114-119 parathyroid hormone Gallus gallus 155-170 20821619-4 2010 Using novel heteronuclear saturation transfer difference nuclear magnetic resonance spectroscopy experiments, human serum albumin (HSA) was identified as the major site of interaction for both PFHxA and PFOA in human sera. perfluorohexanoic acid 193-198 albumin Homo sapiens 116-129 34562756-7 2022 In general, average total PFAS was higher in tap water (86.3 ng L-1) than in surface waters (46.3 ng L-1), whereas the most predominant and frequently detected PFAS were PFBA, PFBS, PFPeA, PFHxA, PFHxS, PFOA and PFOS. perfluorohexanoic acid 189-194 nuclear RNA export factor 1 Homo sapiens 45-48 35131581-8 2022 Exposure to 0.48 mg/L PFHxA increased the expression levels of the thyrotrophic-releasing hormone (trh) and thyroid hormone receptor alpha (tralpha). perfluorohexanoic acid 22-27 thyroid hormone receptor alpha a Danio rerio 140-147 35131581-9 2022 Significant increases in corticotrophin-releasing hormone (crh) and transthyretin (ttr) gene expression were also observed when the zebrafish larvae were treated with 12 mg/L PFHxA, except iodothyronine deiodinases (dio1), which decreased obviously at that point. perfluorohexanoic acid 175-180 transthyretin (prealbumin, amyloidosis type I) Danio rerio 68-81 35131581-9 2022 Significant increases in corticotrophin-releasing hormone (crh) and transthyretin (ttr) gene expression were also observed when the zebrafish larvae were treated with 12 mg/L PFHxA, except iodothyronine deiodinases (dio1), which decreased obviously at that point. perfluorohexanoic acid 175-180 transthyretin (prealbumin, amyloidosis type I) Danio rerio 83-86 35131581-9 2022 Significant increases in corticotrophin-releasing hormone (crh) and transthyretin (ttr) gene expression were also observed when the zebrafish larvae were treated with 12 mg/L PFHxA, except iodothyronine deiodinases (dio1), which decreased obviously at that point. perfluorohexanoic acid 175-180 iodothyronine deiodinase 1 Danio rerio 216-220 35131581-10 2022 There were significant declines in the transcription of both thyroid-stimulating hormone beta (tshbeta) and uridinediphosphate-glucuronosyltransferase (ugt1ab) upon exposure to 2.4 mg/L PFHxA. perfluorohexanoic acid 186-191 UDP glucuronosyltransferase 1 family a, b Danio rerio 152-158 35121066-11 2022 Interestingly, PFHxA and PFHxS induced an increase in CYP2E1 activity, whereas 4:2 FTOH strongly induced CYP2D6 activity. perfluorohexanoic acid 15-20 cytochrome P450 family 2 subfamily E member 1 Homo sapiens 54-60 35121066-11 2022 Interestingly, PFHxA and PFHxS induced an increase in CYP2E1 activity, whereas 4:2 FTOH strongly induced CYP2D6 activity. perfluorohexanoic acid 15-20 cytochrome P450 family 2 subfamily D member 6 Homo sapiens 105-111 35121066-14 2022 Additionally, CYP2C19 was competitively inhibited by PFHxA, PFOS and PFNA, whereas PFBS and PFHxS induced a mixed inhibition. perfluorohexanoic acid 53-58 cytochrome P450 family 2 subfamily C member 19 Homo sapiens 14-21 32062971-3 2020 6:2 FTS was simultaneously transformed to perfluoroalkyl carboxylic acids (C2-C7 PFCAs) of different chain length, with perfluorohexanoic acid (C6) as the predominant one. perfluorohexanoic acid 120-142 AKT interacting protein Homo sapiens 4-7 31404904-7 2019 The results showed that for a 2-log PFHxA abatement (99% removal), the optimal two membrane stages using the NF90 membrane obtains a 75.8% (6.4 $ m-3) reduction of the total costs, compared to the ELOX alone scenario (26.5 $ m-3). perfluorohexanoic acid 36-41 interleukin enhancer binding factor 3 Homo sapiens 109-113 30983446-1 2019 This article presents a supplemental data analysis and evaluation of the findings from an oral (gavage) combined developmental and perinatal/postnatal reproduction toxicity study of the ammonium salt of perfluorohexanoic acid (CASRN: 21615-47-4) in Crl: CD-1(ICR) mice. perfluorohexanoic acid 203-225 CD1 antigen complex Mus musculus 254-263 29710648-3 2018 The predominant compounds in tap water were perfluorohexane sulfonate (PFHxS), perfluoropentanoic acid (PFPeA), perfluorohexanoic acid (PFHxA), perfluorooctanoic acid (PFOA), tris(2-chloroethyl) phosphate (TCEP), tris(chloroisopropyl) phosphate (TCIPP), and tris(2-butoxyethyl) phosphate (TBOEP). perfluorohexanoic acid 136-141 nuclear RNA export factor 1 Homo sapiens 29-32 28157603-1 2017 The present study was aimed at the development of a strategy for removing and degrading perfluorohexanoic acid (PFHxA) from industrial process waters at concentrations in the range 60-200 mg L-1. perfluorohexanoic acid 88-110 immunoglobulin kappa variable 1-16 Homo sapiens 191-194 28157603-1 2017 The present study was aimed at the development of a strategy for removing and degrading perfluorohexanoic acid (PFHxA) from industrial process waters at concentrations in the range 60-200 mg L-1. perfluorohexanoic acid 112-117 immunoglobulin kappa variable 1-16 Homo sapiens 191-194 28157603-4 2017 The NF operation in concentration mode enabled a volume reduction factor of 5 and increased the PFHxA concentration in the retentate to 870 mg L-1. perfluorohexanoic acid 96-101 immunoglobulin kappa variable 1-16 Homo sapiens 143-146