PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
2566467-8	1989	These findings suggest that 3-methylindole is metabolized to alkylating, electrophilic intermediates preferentially by the homologues of "phenobarbital-inducible" isozymes (presumably forms 2 and 5 in analogy to rabbit lung isozymes) to cytochrome P-450 in pulmonary microsomes, rather than by the polycyclic aromatic hydrocarbon-inducible isozymes.	Skatole	28-42	cytochrome P-450	Oryctolagus cuniculus	237-253
2566467-0	1989	Inhibition of 3-methylindole bioactivation by the cytochrome P-450 suicide substrates 1-aminobenzotriazole and alpha-methylbenzylaminobenzotriazole.	Skatole	14-28	cytochrome P-450	Oryctolagus cuniculus	50-66
30171805-3	2019	Moreover, porcine CYP2A19 and CYP2E1 are responsible for the biotransformation of both endogenous and exogenous compounds such as 3-methylindole (skatole), sex hormones and food compounds.	Skatole	130-144	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	30-36
2985085-0	1985	Spin-trapping studies on the effects of vitamin E and glutathione on free radical production induced by 3-methylindole.	Skatole	104-118	spindlin 1	Homo sapiens	0-4
7118077-2	1982	Hydrogenbromide/dimethylsulfoxide and 3-bromo-2-(2-nitrophenylsulfenyl)skatol (BNPS-skatol) cleaved lipophilin into four fragments of molecular masses of approximately 14000 (Trp I), 2100 (Trp II), 5000 (Trp III) and 7000 Da (Trp IV).	Skatole	71-77	proteolipid protein 1	Bos taurus	100-110
6767558-0	1980	[Purification and partial sequence of a hydrophobic polypeptide from BNPS-skatole cleaved bovine rhodopsin].	Skatole	74-81	rhodopsin	Bos taurus	97-106
6767558-1	1980	Rhodopsin isolated from outer segments of cattle retinas was cleaved at tryptophan residues by the BNPS-skatole.	Skatole	104-111	rhodopsin	Bos taurus	0-9
30739789-0	2019	Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.	Skatole	0-7	aryl hydrocarbon receptor	Homo sapiens	78-104
30739789-0	2019	Skatole regulates intestinal epithelial cellular functions through activating aryl hydrocarbon receptors and p38.	Skatole	0-7	mitogen-activated protein kinase 14	Homo sapiens	109-112
30739789-6	2019	In addition to increased AhR transcriptional activity induced by skatole, the AhR antagonist CH223191 partially suppressed of skatole-induced IEC death.	Skatole	65-72	aryl hydrocarbon receptor	Homo sapiens	25-28
30739789-6	2019	In addition to increased AhR transcriptional activity induced by skatole, the AhR antagonist CH223191 partially suppressed of skatole-induced IEC death.	Skatole	126-133	aryl hydrocarbon receptor	Homo sapiens	78-81
30739789-7	2019	Extracellular signal-related kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) are mitogen-activated protein kinases (MAPK) induced by skatole.	Skatole	137-144	mitogen-activated protein kinase 1	Homo sapiens	0-35
30739789-7	2019	Extracellular signal-related kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) are mitogen-activated protein kinases (MAPK) induced by skatole.	Skatole	137-144	mitogen-activated protein kinase 1	Homo sapiens	37-40
30739789-7	2019	Extracellular signal-related kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) are mitogen-activated protein kinases (MAPK) induced by skatole.	Skatole	137-144	mitogen-activated protein kinase 14	Homo sapiens	43-46
30739789-7	2019	Extracellular signal-related kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) are mitogen-activated protein kinases (MAPK) induced by skatole.	Skatole	137-144	mitogen-activated protein kinase 8	Homo sapiens	51-74
30739789-7	2019	Extracellular signal-related kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) are mitogen-activated protein kinases (MAPK) induced by skatole.	Skatole	137-144	mitogen-activated protein kinase 8	Homo sapiens	76-79
30739789-7	2019	Extracellular signal-related kinase (ERK), p38 and c-Jun N-terminal kinase (JNK) are mitogen-activated protein kinases (MAPK) induced by skatole.	Skatole	137-144	mitogen-activated protein kinase 1	Homo sapiens	120-124
30739789-8	2019	None of them were repressed by CH223191, whereas the p38 inhibitor SB203580 promoted skatole-induced IEC death.	Skatole	85-92	mitogen-activated protein kinase 14	Homo sapiens	53-56
30739789-9	2019	These findings together indicated that skatole induces both AhR-dependent activation pathways and the AhR-independent activation of p38, consequently regulating the amount of IEC death.	Skatole	39-46	aryl hydrocarbon receptor	Homo sapiens	60-63
30739789-9	2019	These findings together indicated that skatole induces both AhR-dependent activation pathways and the AhR-independent activation of p38, consequently regulating the amount of IEC death.	Skatole	39-46	aryl hydrocarbon receptor	Homo sapiens	102-105
30739789-9	2019	These findings together indicated that skatole induces both AhR-dependent activation pathways and the AhR-independent activation of p38, consequently regulating the amount of IEC death.	Skatole	39-46	mitogen-activated protein kinase 14	Homo sapiens	132-135
7225464-1	1981	Bovine rhodopsin from retinal rod photoreceptors, a protein of 39,000 molecular weight, was cleaved by BNPS-Skatole at the level of tryptophanyl bonds.	Skatole	108-115	rhodopsin	Bos taurus	7-16
30939354-10	2019	Decreased intestinal skatole formation by immunocastration appeared to be associated with the attenuated actions of IGF1 on the turnover of both ileal and colon mucosa.	Skatole	21-28	IGF1	Sus scrofa	116-120
30599194-0	2019	End-product inhibition of skatole-metabolising enzymes CYP1A, CYP2A19 and CYP2E1 in porcine and piscine hepatic microsomes.	Skatole	26-33	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	62-69
30599194-0	2019	End-product inhibition of skatole-metabolising enzymes CYP1A, CYP2A19 and CYP2E1 in porcine and piscine hepatic microsomes.	Skatole	26-33	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	74-80
30599194-4	2019	Using microsomes from pigs and fish, we determined the ability of several skatole metabolites to inhibit CYP1 A, CYP2A19 and CYP2E1 dependent activity.	Skatole	74-81	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	113-120
30599194-4	2019	Using microsomes from pigs and fish, we determined the ability of several skatole metabolites to inhibit CYP1 A, CYP2A19 and CYP2E1 dependent activity.	Skatole	74-81	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	125-131
30171805-3	2019	Moreover, porcine CYP2A19 and CYP2E1 are responsible for the biotransformation of both endogenous and exogenous compounds such as 3-methylindole (skatole), sex hormones and food compounds.	Skatole	146-153	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	30-36
28475954-0	2017	Association analysis of SNPs in the porcine CYP2E1 gene with skatole, indole, and androstenone levels in backfat of a crossbred pig population.	Skatole	61-68	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	44-50
29151343-0	2017	Deuterium-Labeling Studies Reveal the Mechanism of Cytochrome P450-Catalyzed Formation of 2-Aminoacetophenone from 3-Methylindole (Skatole) in Porcine Liver Microsomes.	Skatole	115-129	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	51-66
29151343-0	2017	Deuterium-Labeling Studies Reveal the Mechanism of Cytochrome P450-Catalyzed Formation of 2-Aminoacetophenone from 3-Methylindole (Skatole) in Porcine Liver Microsomes.	Skatole	131-138	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	51-66
29151343-2	2017	Surprisingly, high formation rates for 2-aminoacetophenone from skatole in microsomal preparations from Pietrain x Baden-Wurttemberg hybrid type boars have been previously demonstrated, but the mechanism of this cytochrome P450-mediated reaction remained unknown.	Skatole	64-71	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	212-227
29468141-6	2018	Among Trp metabolites, AhR ligands consist of endogenous metabolites, including kynurenine, kynurenic acid, xanthurenic acid, and cinnabarinic acid, and bacterial metabolites, including indole, indole propionic acid, indole acetic acid, skatole, and tryptamine.	Skatole	237-244	aryl hydrocarbon receptor	Homo sapiens	23-26
28004617-12	2017	Hepatic gene expression of CYP isoenzymes did not differ between-treatment groups, but was negatively correlated (P<0.05) with androstenone (CYP2E1 and CYP1A2), skatole (CYP2E1, CYP2A) and indole (CYP2A) level.	Skatole	164-171	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	27-30
28475954-2	2017	The aim of this study was to analyse associations of four single nucleotide polymorphisms (SNPs) in the porcine CYP2E1 gene with skatole, indole, and androstenone levels in the Czech Large White-Czech Landrace commercial crossbreds.	Skatole	129-136	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	112-118
25465797-0	2015	Gender-related differences in the formation of skatole metabolites by specific CYP450 in porcine hepatic S9 fractions.	Skatole	47-54	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	79-85
27138278-0	2016	Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.	Skatole	0-7	aryl hydrocarbon receptor	Homo sapiens	38-63
27138278-0	2016	Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.	Skatole	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	84-90
27138278-0	2016	Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.	Skatole	0-7	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	97-103
27138278-0	2016	Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.	Skatole	9-23	aryl hydrocarbon receptor	Homo sapiens	38-63
27138278-0	2016	Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.	Skatole	9-23	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	84-90
27138278-0	2016	Skatole (3-Methylindole) Is a Partial Aryl Hydrocarbon Receptor Agonist and Induces CYP1A1/2 and CYP1B1 Expression in Primary Human Hepatocytes.	Skatole	9-23	cytochrome P450 family 1 subfamily B member 1	Homo sapiens	97-103
27138278-3	2016	Skatole is a pulmonary toxin that induces the expression of aryl hydrocarbon receptor (AhR) regulated genes, such as cytochrome P450 1A1 (CYP1A1), in human bronchial cells.	Skatole	0-7	aryl hydrocarbon receptor	Homo sapiens	60-85
27138278-3	2016	Skatole is a pulmonary toxin that induces the expression of aryl hydrocarbon receptor (AhR) regulated genes, such as cytochrome P450 1A1 (CYP1A1), in human bronchial cells.	Skatole	0-7	aryl hydrocarbon receptor	Homo sapiens	87-90
27138278-3	2016	Skatole is a pulmonary toxin that induces the expression of aryl hydrocarbon receptor (AhR) regulated genes, such as cytochrome P450 1A1 (CYP1A1), in human bronchial cells.	Skatole	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	117-136
27138278-3	2016	Skatole is a pulmonary toxin that induces the expression of aryl hydrocarbon receptor (AhR) regulated genes, such as cytochrome P450 1A1 (CYP1A1), in human bronchial cells.	Skatole	0-7	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	138-144
27138278-7	2016	Specific AhR antagonists and siRNA-mediated AhR silencing demonstrated that skatole-induced CYP1A1 expression is dependent on AhR activation.	Skatole	76-83	aryl hydrocarbon receptor	Homo sapiens	9-12
27138278-7	2016	Specific AhR antagonists and siRNA-mediated AhR silencing demonstrated that skatole-induced CYP1A1 expression is dependent on AhR activation.	Skatole	76-83	aryl hydrocarbon receptor	Homo sapiens	44-47
27138278-7	2016	Specific AhR antagonists and siRNA-mediated AhR silencing demonstrated that skatole-induced CYP1A1 expression is dependent on AhR activation.	Skatole	76-83	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	92-98
27138278-7	2016	Specific AhR antagonists and siRNA-mediated AhR silencing demonstrated that skatole-induced CYP1A1 expression is dependent on AhR activation.	Skatole	76-83	aryl hydrocarbon receptor	Homo sapiens	44-47
27138278-9	2016	Finally, skatole could reduce TCDD-induced CYP1A1 expression, suggesting that skatole is a partial AhR agonist.	Skatole	9-16	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
27138278-9	2016	Finally, skatole could reduce TCDD-induced CYP1A1 expression, suggesting that skatole is a partial AhR agonist.	Skatole	78-85	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	43-49
27138278-9	2016	Finally, skatole could reduce TCDD-induced CYP1A1 expression, suggesting that skatole is a partial AhR agonist.	Skatole	78-85	aryl hydrocarbon receptor	Homo sapiens	99-102
27138278-10	2016	In conclusion, our findings suggest that skatole and its metabolites affect liver homeostasis by modulating the AhR pathway.	Skatole	41-48	aryl hydrocarbon receptor	Homo sapiens	112-115
26047979-2	2015	Significant association (P<0.05) was detected for SNP of FMO5 (g.494A>G) with all boar taint compounds, SNP of CYP21 (g.3911T>C) with skatole and indole, and SNP of ESR1 (g.672C>T) with androstenone and indole.	Skatole	143-150	flavin containing dimethylaniline monoxygenase 5	Homo sapiens	60-64
26047979-2	2015	Significant association (P<0.05) was detected for SNP of FMO5 (g.494A>G) with all boar taint compounds, SNP of CYP21 (g.3911T>C) with skatole and indole, and SNP of ESR1 (g.672C>T) with androstenone and indole.	Skatole	143-150	cytochrome P450 family 21 subfamily A member 2	Homo sapiens	117-122
27080076-4	2016	Skatole levels in fat were negatively correlated to CYP2E1 activity and positively to 3-hydroxy-3-methyloxindole (HMOI), indole-3-carboxylic acid (ICA) and 2-aminoacetophenone in urine.	Skatole	0-7	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	52-58
27080076-6	2016	In summary, the present study provided further evidence for the key role of CYP2E1 in skatole metabolism and suggested that measurement of HMOI and/or ICA in urine might provide information about skatole levels in live pigs.	Skatole	86-93	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	76-82
25990887-4	2015	Therefore, the overall aim of this study was to investigate if increased pig and pen soiling increases skatole concentration in entire male pigs.	Skatole	103-110	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	81-84
25990887-10	2015	Moreover, outdoor pen soiling significantly affected skatole concentration in interactions with herd and season (P<0.001 and P=0.003) and affected human nose positive risk in interaction with herd (P=0.005).	Skatole	53-60	proprotein convertase subtilisin/kexin type 1 inhibitor	Homo sapiens	18-21
25532870-9	2015	Carbaryl, 2-methylindole, and 3-methylindole induced the highest CYP1A activity in zebrafish.	Skatole	30-44	cytochrome P450, family 1, subfamily A	Danio rerio	65-70
25532870-16	2015	However, CYP1A knockdown in phenanthrene and 3-methylindole only moderately increased pericardial edema relative to coexposure to FL.	Skatole	45-59	cytochrome P450, family 1, subfamily A	Danio rerio	9-14
25465797-2	2015	In the present study, skatole metabolites and cytochrome P450 (CYP450) isoforms involved in skatole metabolism were for the first time investigated in hepatic S9 fractions from six male and four female pigs (crossbred LandracexYorkshire dams and Duroc boar).	Skatole	92-99	cytochrome P450 family 2 subfamily D member 6	Sus scrofa	63-69
23036943-4	2013	Androstenone and skatole levels in the tested boar meat ranged from 0.51 to 2.72 mug/g and 0.01 to 0.23 mug/g melted fat, respectively.	Skatole	17-24	FAT atypical cadherin 1	Homo sapiens	117-120
25634945-1	2015	nov., a 3-methylindole- (skatole) and 4-methylphenol- (p-cresol) producing bacterium isolated from pig faeces.	Skatole	8-22	cellular communication network factor 3	Sus scrofa	0-3
25634945-1	2015	nov., a 3-methylindole- (skatole) and 4-methylphenol- (p-cresol) producing bacterium isolated from pig faeces.	Skatole	25-32	cellular communication network factor 3	Sus scrofa	0-3
28706624-3	2015	Here we present kinetic, synthetic, and spectroscopic evidence of the mechanistic behavior of fac-Ir(ppy)3 in a visible light-mediated radical addition to 3-methylindole, demonstrating the instability of fac-Ir(ppy)3 under these conditions.	Skatole	155-169	FA complementation group C	Homo sapiens	94-97
28706624-3	2015	Here we present kinetic, synthetic, and spectroscopic evidence of the mechanistic behavior of fac-Ir(ppy)3 in a visible light-mediated radical addition to 3-methylindole, demonstrating the instability of fac-Ir(ppy)3 under these conditions.	Skatole	155-169	FA complementation group C	Homo sapiens	204-207
25408844-2	2014	Among substrates for CYP450 is the tryptophan metabolite skatole (3-methylindole), one of the major contributors to the off-odour associated with boar-tainted meat.	Skatole	57-64	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-27
25408844-2	2014	Among substrates for CYP450 is the tryptophan metabolite skatole (3-methylindole), one of the major contributors to the off-odour associated with boar-tainted meat.	Skatole	66-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	21-27
24894739-10	2014	RESULTS: A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14 (SSC14), which encodes an enzyme involved in degradation of skatole.	Skatole	73-80	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	108-114
24894739-10	2014	RESULTS: A highly significant association was found between variation in skatole levels and SNPs within the CYP2E1 gene on chromosome 14 (SSC14), which encodes an enzyme involved in degradation of skatole.	Skatole	197-204	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	108-114
24333270-6	2014	The investigated sex-steroids had no effect on the mRNA expression of 3beta-HSD and SULT2A1, while skatole decreased the content of SULT2A1 30% compared to control.	Skatole	99-106	sulfotransferase family 2A member 1	Sus scrofa	132-139
23032374-8	2013	FXR had the greatest effect on 3MI metabolism, increasing the expression of CYP2E1 by 1.29-fold and increasing the production of the key metabolite 6-hydroxy-3-methylindole (6-OH-3MI), while decreasing 5-hydroxy-3-methylindole (5-OH-3MI) production.	Skatole	31-34	nuclear receptor subfamily 1 group H member 4	Homo sapiens	0-3
23032374-8	2013	FXR had the greatest effect on 3MI metabolism, increasing the expression of CYP2E1 by 1.29-fold and increasing the production of the key metabolite 6-hydroxy-3-methylindole (6-OH-3MI), while decreasing 5-hydroxy-3-methylindole (5-OH-3MI) production.	Skatole	31-34	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	76-82
22795630-0	2012	A single nucleotide polymorphism in the CYP2E1 gene promoter affects skatole content in backfat of boars of two commercial Duroc-sired crossbred populations.	Skatole	69-76	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	40-46
22795630-2	2012	This study aimed to investigate how the malodorous compound skatole is affected by a single nucleotide polymorphism (g.2412 C>T at -586 ATG) in the porcine cytochrome p450 II E1 (CYP2E1) gene.	Skatole	60-67	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	182-188
22901340-1	2012	Cytochrome P450 2F1 (P450 2F1) is expressed exclusively in the human respiratory tract and is implicated in 3-methylindole (3MI)-induced pneumotoxicity via dehydrogenation of 3MI to a reactive electrophilic intermediate, 3-methyleneindolenine (3-MEI).	Skatole	108-122	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	0-19
22901340-1	2012	Cytochrome P450 2F1 (P450 2F1) is expressed exclusively in the human respiratory tract and is implicated in 3-methylindole (3MI)-induced pneumotoxicity via dehydrogenation of 3MI to a reactive electrophilic intermediate, 3-methyleneindolenine (3-MEI).	Skatole	124-127	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	0-19
22901340-1	2012	Cytochrome P450 2F1 (P450 2F1) is expressed exclusively in the human respiratory tract and is implicated in 3-methylindole (3MI)-induced pneumotoxicity via dehydrogenation of 3MI to a reactive electrophilic intermediate, 3-methyleneindolenine (3-MEI).	Skatole	175-178	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	0-19
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	252-259	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	56-75
22558931-0	2012	The roles of different porcine cytochrome P450 enzymes and cytochrome b5A in skatole metabolism.	Skatole	77-84	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	31-46
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	252-259	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	77-83
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	252-259	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	104-109
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	19-26	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	56-75
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	19-26	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	77-83
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	252-259	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-71
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	19-26	cytochrome P450 family 2 subfamily A member 13	Homo sapiens	104-109
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	19-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	56-71
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	19-26	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	142-148
22558931-2	2012	The key enzymes in skatole metabolism are thought to be cytochrome P450 2E1 (CYP2E1) and cytochrome 2A (CYP2A); however, the cytochrome P450 (CYP450) isoform responsible for the production of the metabolite 6-hydroxy-3-methylindole (6-OH-3MI, 6-hydroxyskatole), which is thought to be involved in the clearance of skatole, has not been established conclusively.	Skatole	252-259	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	142-148
22558931-3	2012	The aim of this study was to characterize the role of porcine CYP450s in skatole metabolism by expressing them individually in the human embryonic kidney HEK293-FT cell line.	Skatole	73-80	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	62-68
22558931-7	2012	Co-transfection with CYB5A increased the production of skatole metabolites by some of the CYP450s, suggesting that CYB5A plays an important role in the metabolism of skatole.	Skatole	55-62	cytochrome b5 type A	Homo sapiens	21-26
22558931-7	2012	Co-transfection with CYB5A increased the production of skatole metabolites by some of the CYP450s, suggesting that CYB5A plays an important role in the metabolism of skatole.	Skatole	55-62	cytochrome b5 type A	Homo sapiens	115-120
22558931-7	2012	Co-transfection with CYB5A increased the production of skatole metabolites by some of the CYP450s, suggesting that CYB5A plays an important role in the metabolism of skatole.	Skatole	166-173	cytochrome b5 type A	Homo sapiens	21-26
22558931-7	2012	Co-transfection with CYB5A increased the production of skatole metabolites by some of the CYP450s, suggesting that CYB5A plays an important role in the metabolism of skatole.	Skatole	166-173	cytochrome b5 type A	Homo sapiens	115-120
22558931-9	2012	Further information regarding the abundance of different CYP450 isoforms is required to fully understand their contribution to skatole metabolism in vivo in the pig.	Skatole	127-134	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	57-63
21091800-1	2011	In pigs, the hepatic cytochrome P450 (CYP) 1A2, 2A and 2E1 activity is important in the regulation of skatole accumulation in adipose tissue.	Skatole	102-109	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	21-46
22228748-0	2012	Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.	Skatole	62-76	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	20-26
22228748-0	2012	Respective roles of CYP2A5 and CYP2F2 in the bioactivation of 3-methylindole in mouse olfactory mucosa and lung: studies using Cyp2a5-null and Cyp2f2-null mouse models.	Skatole	62-76	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	31-37
22228748-1	2012	The aim of this study was to determine whether mouse CYP2A5 and CYP2F2 play critical roles in the bioactivation of 3-methylindole (3MI), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (OM) and lung.	Skatole	115-129	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	53-59
22228748-1	2012	The aim of this study was to determine whether mouse CYP2A5 and CYP2F2 play critical roles in the bioactivation of 3-methylindole (3MI), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (OM) and lung.	Skatole	115-129	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	64-70
22228748-1	2012	The aim of this study was to determine whether mouse CYP2A5 and CYP2F2 play critical roles in the bioactivation of 3-methylindole (3MI), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (OM) and lung.	Skatole	131-134	cytochrome P450, family 2, subfamily a, polypeptide 5	Mus musculus	53-59
22228748-1	2012	The aim of this study was to determine whether mouse CYP2A5 and CYP2F2 play critical roles in the bioactivation of 3-methylindole (3MI), a tissue-selective toxicant, in the target tissues, the nasal olfactory mucosa (OM) and lung.	Skatole	131-134	cytochrome P450, family 2, subfamily f, polypeptide 2	Mus musculus	64-70
21056093-2	2011	In porcine liver, CYP1A2, 2A and 2E1 are important for the metabolism of skatole.	Skatole	73-80	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	18-24
20403129-1	2011	Cytochrome P450 2E1 (CYP2E1) and 2A (CYP2A) are the main enzymes involved in the metabolism of skatole in pigs.	Skatole	95-102	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	0-19
20403129-1	2011	Cytochrome P450 2E1 (CYP2E1) and 2A (CYP2A) are the main enzymes involved in the metabolism of skatole in pigs.	Skatole	95-102	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	21-27
20403129-1	2011	Cytochrome P450 2E1 (CYP2E1) and 2A (CYP2A) are the main enzymes involved in the metabolism of skatole in pigs.	Skatole	95-102	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	37-42
20580070-5	2010	Following stimulation with hCG the relative increases in testosterone, androstenone, and skatole concentrations were highest in Landrace boars.	Skatole	89-96	chorionic gonadotropin subunit beta 5	Homo sapiens	27-30
21535714-1	2011	The off-flavor boar taint associated with the substances skatole, androstenone, and possibly indole represents a significant problem in the pig husbandry industry.	Skatole	57-64	OFFFLAV	Sus scrofa	4-14
20187624-0	2010	3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.	Skatole	0-14	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	39-45
20623327-0	2010	Odorant receptor from the southern house mosquito narrowly tuned to the oviposition attractant skatole.	Skatole	95-102	putative odorant receptor 83c	Culex quinquefasciatus	0-16
20623327-5	2010	Here, we describe the characterization of an odorant receptor (OR), CquiOR10, which is narrowly tuned to skatole when expressed in the Xenopus oocyte system.	Skatole	105-112	putative odorant receptor 83c	Culex quinquefasciatus	45-61
20187624-0	2010	3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.	Skatole	0-14	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	50-56
20187624-0	2010	3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.	Skatole	0-14	aryl hydrocarbon receptor	Homo sapiens	68-71
20187624-0	2010	3-Methylindole metabolites induce lung CYP1A1 and CYP2F1 enzymes by AhR and non-AhR mechanisms, respectively.	Skatole	0-14	aryl hydrocarbon receptor	Homo sapiens	80-83
20187624-9	2010	Treatment with 3MI in combination with the AhR antagonist alpha-naphthoflavone prevented 3MI-mediated CYP1A1 induction, indicating that the induction was AhR-dependent.	Skatole	15-18	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-108
20187624-9	2010	Treatment with 3MI in combination with the AhR antagonist alpha-naphthoflavone prevented 3MI-mediated CYP1A1 induction, indicating that the induction was AhR-dependent.	Skatole	15-18	aryl hydrocarbon receptor	Homo sapiens	154-157
20187624-9	2010	Treatment with 3MI in combination with the AhR antagonist alpha-naphthoflavone prevented 3MI-mediated CYP1A1 induction, indicating that the induction was AhR-dependent.	Skatole	89-92	aryl hydrocarbon receptor	Homo sapiens	43-46
20187624-9	2010	Treatment with 3MI in combination with the AhR antagonist alpha-naphthoflavone prevented 3MI-mediated CYP1A1 induction, indicating that the induction was AhR-dependent.	Skatole	89-92	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	102-108
19831375-9	2009	The binding energies for both the sigma-type and pi-type hydrogen-bonded M.L complexes (M = indole and 3-methylindole; L = H(2)O and H(2)S) were calculated by extrapolating MP2 interaction energies to the complete basis set limit.	Skatole	103-117	tryptase pseudogene 1	Homo sapiens	173-176
19835364-5	2009	In contrast, in parvalbumin, where the chromophore is embedded in the protein core, the structure and emission maxima are the same as those of an isolated 3-methylindole fluorophore.	Skatole	155-169	parvalbumin	Homo sapiens	16-27
19575819-10	2009	Haplotype analysis provided additional evidence for an effect of CYP2E1 on levels of skatole and indole, and for BAP1, HYAL2 and SRD5A2 on levels of androstenone.	Skatole	85-92	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	65-71
17962375-11	2008	In conclusion, this study presents evidence that 3MI is a mechanism-based inhibitor of both CYP2F3 and CYP2F1, which are important enzymes in the bioactivation of pneumotoxicants such as 3MI or 1,1-dichloroethylene or carcinogens such as naphthalene, benzene, and styrene.	Skatole	49-52	cytochrome P450 family 2 subfamily F member 3	Capra hircus	92-98
20027142-0	2009	Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system.	Skatole	61-68	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	8-15
20027142-0	2009	Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system.	Skatole	61-68	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	17-23
20027142-0	2009	Porcine CYP2A19, CYP2E1 and CYP1A2 forms are responsible for skatole biotransformation in the reconstituted system.	Skatole	61-68	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	28-34
20027142-1	2009	OBJECTIVES: To study the contribution of individual purified porcine CYP1A2, 2E1 and 2A19 enzymes to the biotransformation of skatole.	Skatole	126-133	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	69-75
20027142-6	2009	Whereas in pig CYP2A19 and CYP1A2 seem to be the most important for metabolism of skatole, in man CYP1A2 and CYP2E1 forms are mainly responsible for the production of the metabolites mentioned above.	Skatole	82-89	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	15-22
20027142-6	2009	Whereas in pig CYP2A19 and CYP1A2 seem to be the most important for metabolism of skatole, in man CYP1A2 and CYP2E1 forms are mainly responsible for the production of the metabolites mentioned above.	Skatole	82-89	cytochrome P450 family 1 subfamily A member 2	Sus scrofa	27-33
20027142-6	2009	Whereas in pig CYP2A19 and CYP1A2 seem to be the most important for metabolism of skatole, in man CYP1A2 and CYP2E1 forms are mainly responsible for the production of the metabolites mentioned above.	Skatole	82-89	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	98-104
20027142-6	2009	Whereas in pig CYP2A19 and CYP1A2 seem to be the most important for metabolism of skatole, in man CYP1A2 and CYP2E1 forms are mainly responsible for the production of the metabolites mentioned above.	Skatole	82-89	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	109-115
18325003-4	2008	Activities of both CYP2E1 and CYP2A were lower in hCG-stimulated pigs than control pigs for both Landrace (p = 0.005 for CYP2E1, p = 0.016 for CYP2A) and Duroc breeds (p = 0.003 for CYP2E1, p = 0.001 for CYP2A), and skatole concentrations in fat were higher in the hCG-stimulated pigs of both breeds (p < 0.01).	Skatole	216-223	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	19-25
18325003-4	2008	Activities of both CYP2E1 and CYP2A were lower in hCG-stimulated pigs than control pigs for both Landrace (p = 0.005 for CYP2E1, p = 0.016 for CYP2A) and Duroc breeds (p = 0.003 for CYP2E1, p = 0.001 for CYP2A), and skatole concentrations in fat were higher in the hCG-stimulated pigs of both breeds (p < 0.01).	Skatole	216-223	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	30-35
18325003-4	2008	Activities of both CYP2E1 and CYP2A were lower in hCG-stimulated pigs than control pigs for both Landrace (p = 0.005 for CYP2E1, p = 0.016 for CYP2A) and Duroc breeds (p = 0.003 for CYP2E1, p = 0.001 for CYP2A), and skatole concentrations in fat were higher in the hCG-stimulated pigs of both breeds (p < 0.01).	Skatole	216-223	hypertrichosis 2 (generalised, congenital)	Homo sapiens	50-53
18325003-5	2008	For both control and hCG-stimulated groups, Duroc pigs had lower skatole concentrations than Landrace pigs (p = 0.001 for both groups).	Skatole	65-72	hypertrichosis 2 (generalised, congenital)	Homo sapiens	21-24
22445012-0	2008	Effect of polymorphism in the porcine cytochrome b5 ( CYB5A) gene on androstenone and skatole concentrations and sexual development in Swedish pig populations.	Skatole	86-93	cytochrome b5 type A	Sus scrofa	38-51
22445012-0	2008	Effect of polymorphism in the porcine cytochrome b5 ( CYB5A) gene on androstenone and skatole concentrations and sexual development in Swedish pig populations.	Skatole	86-93	cytochrome b5 type A	Sus scrofa	54-59
22445012-1	2008	The present study investigated the presence of a single-nucleotide polymorphism (G > T) at base -8 upstream of ATG in 5" untranslated region of cytochrome b5 (CYB5A) gene in Swedish pig populations and evaluated the significance of this polymorphism for androstenone and skatole levels, sexual development and performance parameters in pigs.	Skatole	274-281	cytochrome b5 type A	Sus scrofa	147-160
22445012-1	2008	The present study investigated the presence of a single-nucleotide polymorphism (G > T) at base -8 upstream of ATG in 5" untranslated region of cytochrome b5 (CYB5A) gene in Swedish pig populations and evaluated the significance of this polymorphism for androstenone and skatole levels, sexual development and performance parameters in pigs.	Skatole	274-281	cytochrome b5 type A	Sus scrofa	162-167
22445012-11	2008	We concluded that the presence of the T allele in the CYB5A gene resulted in lower androstenone levels in plasma, and lower skatole levels in fat and plasma; this reduction, however, was dependent on the live weight of the animals.	Skatole	124-131	cytochrome b5 type A	Sus scrofa	54-59
17908921-0	2008	Regulation of CYP2A6 protein expression by skatole, indole, and testicular steroids in primary cultured pig hepatocytes.	Skatole	43-50	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	14-20
17908921-1	2008	CYP2A6 is one of the enzymes involved in the hepatic metabolism of a naturally produced compound, skatole, in the pig.	Skatole	98-105	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	0-6
17908921-2	2008	Low CYP2A6 activity has been linked to excessive accumulation of skatole in pig adipose tissue and development of the phenomenon "boar taint."	Skatole	65-72	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	4-10
17908921-5	2008	The study has also examined whether CYP2A6 expression can be modulated by the boar taint compounds skatole and indole.	Skatole	99-106	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	36-42
17908921-7	2008	In contrast to androstenone, skatole and indole (final concentrations, 1, 10, and 100 nM) had a stimulatory effect on CYP2A6 expression.	Skatole	29-36	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	118-124
17908921-11	2008	The hormonal modulation of CYP2A6 expression might contribute to gender-related differences in pig hepatic CYP2A6 activity and skatole accumulation in pig adipose tissue.	Skatole	127-134	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	27-33
17962375-11	2008	In conclusion, this study presents evidence that 3MI is a mechanism-based inhibitor of both CYP2F3 and CYP2F1, which are important enzymes in the bioactivation of pneumotoxicants such as 3MI or 1,1-dichloroethylene or carcinogens such as naphthalene, benzene, and styrene.	Skatole	49-52	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	103-109
16167985-0	2005	Cloning and mapping of the porcine cytochrome-p450 2E1 gene and its association with skatole levels in the domestic pig.	Skatole	85-92	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	35-54
17156906-2	2007	This is the first in vitro study indicating that sex steroids have a potential to modify microsomal CYP2E1 activity, the main skatole-metabolising enzyme.	Skatole	126-133	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	100-106
16978187-0	2006	Assessment of SULT1A1, CYP2A6 and CYP2C18 as candidate genes for elevated backfat skatole levels in commercial and experimental pig populations.	Skatole	82-89	sulfotransferase 1A3	Sus scrofa	14-21
16978187-0	2006	Assessment of SULT1A1, CYP2A6 and CYP2C18 as candidate genes for elevated backfat skatole levels in commercial and experimental pig populations.	Skatole	82-89	CYP2C18	Sus scrofa	34-41
16677611-6	2006	In addition, CYP2W1 showed monooxygenase activity towards 3-methylindole and chlorzoxazone.	Skatole	58-72	cytochrome P450 family 2 subfamily W member 1	Homo sapiens	13-19
16821288-0	2006	Functional polymorphism in porcine CYP2E1 gene: Its association with skatole levels.	Skatole	69-76	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	35-41
16821288-3	2006	The excessive accumulation of skatole in fat is a major cause of boar taint, and is associated with defective expression of cytochrome P4502E1 (CYP2E1).	Skatole	30-37	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	124-142
16821288-3	2006	The excessive accumulation of skatole in fat is a major cause of boar taint, and is associated with defective expression of cytochrome P4502E1 (CYP2E1).	Skatole	30-37	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	144-150
16821288-4	2006	In pigs, it has been found that CYP2E1 is negatively correlated with accumulation of skatole.	Skatole	85-92	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	32-38
16821288-6	2006	The aim of this study was to measure the expression pattern of CYP2E1 mRNA in various tissues of the pig, to identify genetic polymorphisms, and to evaluate the functional relevance of polymorphic sites with respect to the skatole level in fat.	Skatole	223-230	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	63-69
16501006-0	2006	The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes.	Skatole	50-64	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	12-17
16501006-0	2006	The role of CYP2A and CYP2E1 in the metabolism of 3-methylindole in primary cultured porcine hepatocytes.	Skatole	50-64	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	22-28
16501006-6	2006	Treatment with general P450 inhibitors resulted in further decreases in CYP2E1 activity and a more dramatic decrease in the production of 3MI metabolites, suggesting that additional P450s may be involved in the phase 1 metabolism of 3-methylindole.	Skatole	233-247	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	72-78
16501006-7	2006	In conclusion, CYP2E1 activity levels are more important than CYP2A activity levels for the metabolism of 3-methylindole in isolated pig hepatocytes.	Skatole	106-120	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	15-21
16501006-7	2006	In conclusion, CYP2E1 activity levels are more important than CYP2A activity levels for the metabolism of 3-methylindole in isolated pig hepatocytes.	Skatole	106-120	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	62-67
22061562-1	2006	Cytochromes P4502E1 (CYP2E1) and P4502A6 (CYP2A6) catalyse metabolic reactions of skatole and indole metabolism.	Skatole	82-89	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	0-19
22061562-1	2006	Cytochromes P4502E1 (CYP2E1) and P4502A6 (CYP2A6) catalyse metabolic reactions of skatole and indole metabolism.	Skatole	82-89	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	21-27
22061562-1	2006	Cytochromes P4502E1 (CYP2E1) and P4502A6 (CYP2A6) catalyse metabolic reactions of skatole and indole metabolism.	Skatole	82-89	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	42-48
22061563-6	2006	The correlation coefficients between androstenone and skatole levels in fat were 0.54 in the hCG-injected group and non-significant in the control group.	Skatole	54-61	hypertrichosis 2 (generalised, congenital)	Homo sapiens	93-96
16877261-3	2006	CYP4B1 also participates in the metabolism of certain xenobiotics that are protoxic, including valproic acid, 3-methylindole, 4-ipomeanol, 3-methoxy-4-aminoazobenzene, and numerous aromatic amines.	Skatole	110-124	cytochrome P450 family 4 subfamily B member 1	Homo sapiens	0-6
16167985-4	2005	One of these markers was used to map the CYP2E1 gene distal of SWC27 on SSC14, well outside reported quantitative trait loci on SSC14 for skatole, indole and taste test measures of boar taint.	Skatole	138-145	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	41-47
16167985-5	2005	However, in a population of commercial pigs scored for backfat skatole levels, there was evidence of association between a SNP in the CYP2E1 promoter and skatole deposition, although there was no significant association between this SNP and skatole levels in the experimental cross.	Skatole	63-70	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	134-140
16167985-5	2005	However, in a population of commercial pigs scored for backfat skatole levels, there was evidence of association between a SNP in the CYP2E1 promoter and skatole deposition, although there was no significant association between this SNP and skatole levels in the experimental cross.	Skatole	154-161	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	134-140
16167985-5	2005	However, in a population of commercial pigs scored for backfat skatole levels, there was evidence of association between a SNP in the CYP2E1 promoter and skatole deposition, although there was no significant association between this SNP and skatole levels in the experimental cross.	Skatole	154-161	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	134-140
12044562-0	2002	Cytochrome P450IIE1 (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes.	Skatole	43-50	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	21-27
22061333-1	2004	High skatole and to a lesser degree indole levels in some entire male pigs result in occurrence of off-flavor in meat, called boar taint.	Skatole	5-12	OFFFLAV	Sus scrofa	99-109
15013816-3	2004	In isolated pig hepatocytes androstenone represses the expression of cytochrome P450IIE1 (CYP2E1), the enzyme principally responsible for skatole metabolism.	Skatole	138-145	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	90-96
15014971-5	2004	We show here that a substitution of A-->G at base 546 of SULT1A1 causes a significant decrease in its sulfation activity and thus may be at least partially responsible for a higher level of skatole in pigs.	Skatole	193-200	sulfotransferase 1A3	Sus scrofa	60-67
12563108-6	2003	Thus, 3MI is cytotoxic to immortalized bronchial epithelial cells overexpressing 2F1 without concomitant depletion of GSH, but depletion of GSH modestly enhances the cytotoxicity of 3MI to human lung cells.	Skatole	6-9	killer cell lectin like receptor G1	Homo sapiens	81-84
15265071-3	2004	It has been shown that CYP2A6 is a key enzyme in the hepatic metabolism of skatole and that the activity of CYP2A6 is negatively correlated with skatole accumulation in fat.	Skatole	75-82	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	23-29
15265071-3	2004	It has been shown that CYP2A6 is a key enzyme in the hepatic metabolism of skatole and that the activity of CYP2A6 is negatively correlated with skatole accumulation in fat.	Skatole	75-82	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	108-114
15265071-3	2004	It has been shown that CYP2A6 is a key enzyme in the hepatic metabolism of skatole and that the activity of CYP2A6 is negatively correlated with skatole accumulation in fat.	Skatole	145-152	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	23-29
15265071-3	2004	It has been shown that CYP2A6 is a key enzyme in the hepatic metabolism of skatole and that the activity of CYP2A6 is negatively correlated with skatole accumulation in fat.	Skatole	145-152	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	108-114
15265071-5	2004	We identified a single base deletion in CYP2A6, resulting in a frame shift in the coding region that produces a non-functional enzyme, which was associated with high levels of skatole in fat tissue.	Skatole	176-183	cytochrome P450 family 2 subfamily A member 19	Sus scrofa	40-46
15013816-13	2004	The differential expression of this enzyme could be a factor affecting the rate of hepatic androstenone metabolism which in turn may influence the level of hepatic CYP2E1 expression and hence the rate of hepatic skatole metabolism.	Skatole	212-219	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	164-170
12044562-1	2002	Skatole, a derivative of tryptophan, is produced in the hind-gut of pigs and is metabolised via hepatic cytochrome P4502E1 (CYP2E1).	Skatole	0-7	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	124-130
12044562-2	2002	Excessive accumulation of skatole together with androstenone, a metabolite of testosterone, in adipose tissue in some pigs is a major cause of "boar taint" and is associated with defective expression of CYP2E1.	Skatole	26-33	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	203-209
12044562-5	2002	Skatole induced CYP2E1 protein expression to the same degree as did acetone, a known CYP2E1 inducer.	Skatole	0-7	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	16-22
12044562-5	2002	Skatole induced CYP2E1 protein expression to the same degree as did acetone, a known CYP2E1 inducer.	Skatole	0-7	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	85-91
12044562-7	2002	Induction of CYP2E1 by skatole was protein-synthesis dependent.	Skatole	23-30	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	13-19
12044562-8	2002	Androstenone antagonised the effect of skatole on CYP2E1 expression but did not affect the CYP2E1 protein level when added alone.	Skatole	39-46	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	50-56
12044562-9	2002	These results suggest that defective expression of CYP2E1 in some pigs is due to excessive concentrations of androstenone which prevent CYP2E1 induction by its substrate skatole.	Skatole	170-177	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	51-57
12044562-9	2002	These results suggest that defective expression of CYP2E1 in some pigs is due to excessive concentrations of androstenone which prevent CYP2E1 induction by its substrate skatole.	Skatole	170-177	cytochrome P450 family 2 subfamily E member 1	Sus scrofa	136-142
11671863-0	1997	Regiospecific Bromination of 3-Methylindoles with NBS and Its Application to the Concise Synthesis of Optically Active Unusual Tryptophans Present in Marine Cyclic Peptides(1).	Skatole	29-44	nibrin	Homo sapiens	50-53
10383923-0	1999	Specific dehydrogenation of 3-methylindole and epoxidation of naphthalene by recombinant human CYP2F1 expressed in lymphoblastoid cells.	Skatole	28-42	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	95-101
10071923-1	1999	A comparative study of various procedures for tryptophanyl peptide bond cleavage by BNPS-skatole [2-(2-nitrophenyl)-3-methyl-3-bromoindolenine] was carried out on native and on reduced and alkylated bovine beta-lactoglobulin (BLG).	Skatole	89-96	beta-lactoglobulin	Bos taurus	206-224
10071923-1	1999	A comparative study of various procedures for tryptophanyl peptide bond cleavage by BNPS-skatole [2-(2-nitrophenyl)-3-methyl-3-bromoindolenine] was carried out on native and on reduced and alkylated bovine beta-lactoglobulin (BLG).	Skatole	89-96	beta-lactoglobulin	Bos taurus	226-229
10725159-0	2000	Role of aldehyde oxidase in the hepatic in vitro metabolism of 3-methylindole in pigs.	Skatole	63-77	aldehyde oxidase 1	Sus scrofa	8-24
9448722-0	1998	Cloning and expression of CYP2F3, a cytochrome P450 that bioactivates the selective pneumotoxins 3-methylindole and naphthalene.	Skatole	97-111	cytochrome P450 family 2 subfamily F member 3	Capra hircus	26-32
9448722-2	1998	Human CYP2F1 bioactivates 3-methylindole (3MI), while mouse CYP2F2 bioactivates naphthalene.	Skatole	26-40	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	6-12
9448722-2	1998	Human CYP2F1 bioactivates 3-methylindole (3MI), while mouse CYP2F2 bioactivates naphthalene.	Skatole	42-45	cytochrome P450 family 2 subfamily F member 1	Homo sapiens	6-12
2260974-1	1990	The partial amino acid sequence of rat sepiapterin reductase was determined using peptides generated by cleavage of the S-carboxyamidomethylated protein with Achromobacter protease I, cyanogen bromide, chymotrypsin or BNPS-skatole.	Skatole	223-230	sepiapterin reductase	Rattus norvegicus	39-60
8825199-0	1996	Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3-methyloxindole formed during 3-methylindole metabolism in goats.	Skatole	119-133	LOW QUALITY PROTEIN: beta-glucuronidase	Capra hircus	18-36
8558432-0	1996	Metabolism of 3-methylindole by vaccinia-expressed P450 enzymes: correlation of 3-methyleneindolenine formation and protein-binding.	Skatole	14-28	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	51-55
8558432-1	1996	The toxicity of 3-methylindole (3 MI), a selective pneumotoxin, is dependent upon cytochrome P450-mediated bioactivation 3.	Skatole	16-30	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	93-97
2206135-1	1990	Large fragments of rabbit serum transferrin have been prepared by enzymatic digestion with subtilisin and by chemical cleavage with BNPS-skatole.	Skatole	137-144	serotransferrin	Oryctolagus cuniculus	32-43