PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 25687659-0 2015 "Empiric" inositol supplementation in normal-weight non insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. Inositol 10-18 insulin Homo sapiens 56-63 25687660-0 2015 Authors" reply to: "Empiric" inositol supplementation in normal-weight non-insulin resistant women with polycystic ovarian disease: from the absence of benefit to the potential adverse effects. Inositol 29-37 insulin Homo sapiens 75-82 25687304-11 2015 Overall the results show that cytosolically made inositol and CDP-diacylglycerol can access the active site of the yeast PI synthase Pis1 from the cytosolic side and that Pis1 structure is strongly affected by mild detergents. Inositol 49-57 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 133-137 25687304-11 2015 Overall the results show that cytosolically made inositol and CDP-diacylglycerol can access the active site of the yeast PI synthase Pis1 from the cytosolic side and that Pis1 structure is strongly affected by mild detergents. Inositol 49-57 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 171-175 25821218-4 2015 In this study, we found that ER stress-induced inositol-requiring enzyme (IRE)1alpha activation differentially regulates proinflammatory cytokine gene expression via activation of glycogen synthase kinase (GSK)-3beta and X-box binding protein (XBP)-1. Inositol 47-55 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 74-84 25821218-4 2015 In this study, we found that ER stress-induced inositol-requiring enzyme (IRE)1alpha activation differentially regulates proinflammatory cytokine gene expression via activation of glycogen synthase kinase (GSK)-3beta and X-box binding protein (XBP)-1. Inositol 47-55 glycogen synthase kinase 3 beta Homo sapiens 180-216 25821218-4 2015 In this study, we found that ER stress-induced inositol-requiring enzyme (IRE)1alpha activation differentially regulates proinflammatory cytokine gene expression via activation of glycogen synthase kinase (GSK)-3beta and X-box binding protein (XBP)-1. Inositol 47-55 X-box binding protein 1 Homo sapiens 221-250 25869668-6 2015 Sac2/INPP5F and OCRL may cooperate in the sequential dephosphorylation of PI(4,5)P2 at the 5 and 4 position of inositol in a partnership that mimics that of the two phosphatase modules of synaptojanin. Inositol 111-119 Vps52p Saccharomyces cerevisiae S288C 0-4 25550457-2 2015 One of the key players in the regulation of inositol lipid signaling is the phospholipase Cbeta1 (PI-PLCbeta1), that hydrolyzes phosphatidylinositol 4,5-bisphosphate [PtIns(4,5)P2], giving rise to the second messengers inositol triphosphate and diacylglicerol. Inositol 44-52 phospholipase C, beta 1 Mus musculus 101-109 25679134-8 2015 Inositol-deficient food-treated animals, both lithium treated and with inositol monophosphatase 1 knockout, had significantly elevated cholinergic behavior rating and significantly increased or earlier seizures compared with the controls. Inositol 0-8 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 71-97 25345501-0 2015 Inositol synthesis regulates the activation of GSK-3alpha in neuronal cells. Inositol 0-8 glycogen synthase kinase 3 alpha Homo sapiens 47-57 25345501-6 2015 Interestingly, the inhibition of inositol synthesis by knocking down INO1, which encodes inositol-3-phosphate synthase, the rate-limiting enzyme of inositol synthesis, led to the inactivation of GSK-3alpha by increasing the inhibitory phosphorylation of this kinase. Inositol 33-41 inositol-3-phosphate synthase 1 Homo sapiens 69-73 25345501-6 2015 Interestingly, the inhibition of inositol synthesis by knocking down INO1, which encodes inositol-3-phosphate synthase, the rate-limiting enzyme of inositol synthesis, led to the inactivation of GSK-3alpha by increasing the inhibitory phosphorylation of this kinase. Inositol 33-41 glycogen synthase kinase 3 alpha Homo sapiens 195-205 25345501-6 2015 Interestingly, the inhibition of inositol synthesis by knocking down INO1, which encodes inositol-3-phosphate synthase, the rate-limiting enzyme of inositol synthesis, led to the inactivation of GSK-3alpha by increasing the inhibitory phosphorylation of this kinase. Inositol 89-97 inositol-3-phosphate synthase 1 Homo sapiens 69-73 25345501-6 2015 Interestingly, the inhibition of inositol synthesis by knocking down INO1, which encodes inositol-3-phosphate synthase, the rate-limiting enzyme of inositol synthesis, led to the inactivation of GSK-3alpha by increasing the inhibitory phosphorylation of this kinase. Inositol 89-97 glycogen synthase kinase 3 alpha Homo sapiens 195-205 25345501-7 2015 Similarly, the mood stabilizer valproic acid effected transient decreases in intracellular inositol, leading to inactivation of GSK-3alpha. Inositol 91-99 glycogen synthase kinase 3 alpha Homo sapiens 128-138 25345501-8 2015 As GSK-3 inhibition has been proposed as a likely therapeutic mechanism of action, the finding that inhibition of inositol synthesis results in the inactivation of GSK-3alpha suggests a unifying hypothesis for mechanism of mood-stabilizing drugs. Inositol 114-122 glycogen synthase kinase 3 alpha Homo sapiens 164-174 28325996-5 2015 Non-targeted metabolomic analysis identified significant differences (via VIP statistical analysis) in taurine, myoinositol, and stearic acid for the three MuRF-/- phenotypes relative to their matched controls. Inositol 112-123 tripartite motif containing 54 Homo sapiens 156-160 26137585-6 2015 In turn, VEGF and VEGFR2 associated within the ER, activating inositol-requiring enzyme 1alpha, and thereby facilitating ERAD-mediated depletion of VEGFR2. Inositol 62-70 vascular endothelial growth factor A Homo sapiens 9-13 26137585-6 2015 In turn, VEGF and VEGFR2 associated within the ER, activating inositol-requiring enzyme 1alpha, and thereby facilitating ERAD-mediated depletion of VEGFR2. Inositol 62-70 kinase insert domain receptor Homo sapiens 18-24 25803873-4 2015 Previously, we demonstrated that calnexin (Cnx1p), a highly conserved transmembrane chaperone of the endoplasmic reticulum (ER), regulates apoptosis under ER stress or inositol starvation. Inositol 168-176 calnexin Homo sapiens 33-41 25781026-4 2015 Consistent with a previous report that Art5p downregulates the inositol transporter Itr1p by endocytosis, we found that flippase mutations were also suppressed by the disruption of ITR1, as well as by depletion of inositol from the culture medium. Inositol 63-71 Art5p Saccharomyces cerevisiae S288C 39-44 25781026-4 2015 Consistent with a previous report that Art5p downregulates the inositol transporter Itr1p by endocytosis, we found that flippase mutations were also suppressed by the disruption of ITR1, as well as by depletion of inositol from the culture medium. Inositol 63-71 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 84-89 25756525-2 2015 The present study explores the SLC5A3 protein as a possible transporter of myo-inositol in hyponically swollen HEK293 cells. Inositol 75-87 solute carrier family 5 member 3 Homo sapiens 31-37 25756525-8 2015 Assuming SLC5A3 to be the major path for myo-inositol, a turnover rate of 80-800 myo-inositol molecules per second for a single transporter protein was estimated from combined volumetric and dSTORM data. Inositol 41-53 solute carrier family 5 member 3 Homo sapiens 9-15 25756525-8 2015 Assuming SLC5A3 to be the major path for myo-inositol, a turnover rate of 80-800 myo-inositol molecules per second for a single transporter protein was estimated from combined volumetric and dSTORM data. Inositol 81-93 solute carrier family 5 member 3 Homo sapiens 9-15 25249581-4 2015 Deleting Ask1 abrogated diabetes-induced UPR by suppressing phosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha), and double-stranded RNA-activated protein kinase (PKR)-like ER kinase (PERK) blocked the mitochondrial translocation of proapoptotic Bcl-2 members and ER stress. Inositol 79-87 mitogen-activated protein kinase kinase kinase 5 Mus musculus 9-13 25457211-3 2015 Here we investigated the role of inositol-requiring enzyme-1alpha (IRE1alpha), a key signal transducer of the unfolded protein response (UPR), in liver regeneration. Inositol 33-41 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 67-76 25405329-4 2015 Small interfering RNA technology was used to knockdown the expression of inositol-requiring enzyme-1alpha (IRE1alpha) and X-box-binding protein-1 (XBP-1), in order to determine their effects on LDL-treated HMCs. Inositol 73-81 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 107-116 25585912-6 2015 RESULTS: There was a significant difference between the NF1 and control groups with regard to the mean values of myoinositol/creatine and choline/creatine, with higher metabolite values observed in the NF1 group (P < 0.001). Inositol 113-124 neurofibromin 1 Homo sapiens 56-59 25585912-6 2015 RESULTS: There was a significant difference between the NF1 and control groups with regard to the mean values of myoinositol/creatine and choline/creatine, with higher metabolite values observed in the NF1 group (P < 0.001). Inositol 113-124 neurofibromin 1 Homo sapiens 202-205 25585912-7 2015 Only the myoinositol/creatine ratio was able to discriminate between NF1 subgroups with and without T2-weighted hyperintensities. Inositol 9-20 neurofibromin 1 Homo sapiens 69-72 33228287-8 2015 The lines with both mutant IPK1 genes had very low PA levels, moderate accumulation of inorganic phosphate (Pi), and accumulation of high amounts of P in lower inositols. Inositol 160-169 inositol pentakisphosphate 2-kinase Glycine max 27-31 33228287-10 2015 In addition, characterization of the lower inositols produced in the mutant lines suggests that IPK1 is a polyphosphate kinase and provides some insight into the PA biosynthesis pathway in soybean seeds. Inositol 43-52 inositol pentakisphosphate 2-kinase Glycine max 96-100 25540432-7 2015 Importantly, other functions of seipin, namely vectorial budding and resistance to inositol, are retained in this mutant. Inositol 83-91 seipin Saccharomyces cerevisiae S288C 32-38 25673847-10 2015 The positive feedback between PLCbeta and IP3R found here may represent a common feature of the inositol-lipid signaling. Inositol 96-104 no receptor potential A Drosophila melanogaster 30-37 25673847-10 2015 The positive feedback between PLCbeta and IP3R found here may represent a common feature of the inositol-lipid signaling. Inositol 96-104 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 42-46 24356728-2 2015 The inositol-requiring enzyme 1-X-box binding protein-1 (IRE1-XBP-1) arm of the UPR pathway has been shown to play crucial roles not only in relieving the ER stress by up-regulating a series of genes favoring ER-associated protein degradation and protein folding, but in mediating terminal plasmacytic differentiation and maturation. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 57-61 24356728-2 2015 The inositol-requiring enzyme 1-X-box binding protein-1 (IRE1-XBP-1) arm of the UPR pathway has been shown to play crucial roles not only in relieving the ER stress by up-regulating a series of genes favoring ER-associated protein degradation and protein folding, but in mediating terminal plasmacytic differentiation and maturation. Inositol 4-12 X-box binding protein 1 Homo sapiens 62-67 25259724-0 2015 Ovulation induction with myo-inositol alone and in combination with clomiphene citrate in polycystic ovarian syndrome patients with insulin resistance. Inositol 25-37 insulin Homo sapiens 132-139 25259724-2 2015 One of the methods for correcting insulin resistance is using myo-inositol. Inositol 62-74 insulin Homo sapiens 34-41 25259724-3 2015 AIM: The aim of the present study is to evaluate the effectiveness of myo-inositol alone or in combination with clomiphene citrate for (1) induction of ovulation and (2) pregnancy rate in anovulatory women with PCOS and proven insulin resistance. Inositol 70-82 insulin Homo sapiens 227-234 25259724-13 2015 CONCLUSION: Myo-inositol treatment ameliorates insulin resistance and body weight, and improves ovarian activity in PCOS patients. Inositol 12-24 insulin Homo sapiens 47-54 25670768-5 2015 Expression of the Gle1 variants with enhanced InsP(6) sensitivity rescues the mRNA export defect of the ipk1 (inositol 1,3,4,5,6-pentakisphosphate 2-kinase) InsP(6)-deficient mutant and, furthermore, significantly improves vegetative growth, seed yield, and seed performance of the mutant. Inositol 110-118 inositol-pentakisphosphate 2-kinase 1 Arabidopsis thaliana 104-108 25602740-3 2015 However, in the more distantly related yeast Yarrowia lipolytica, the OPI1 homolog was not found to regulate inositol biosynthesis, but alkane oxidation. Inositol 109-117 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 70-74 25602740-4 2015 In Candida albicans, the most common cause of human candidiasis, its Opi1p homolog, CaOpi1p, has been shown to complement a S. cerevisiae opi1 mutant for inositol biosynthesis regulation when heterologously expressed, suggesting it might serve a similar role in this pathogen. Inositol 155-163 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 138-142 25499604-5 2015 In addition, we found significantly lower levels of myo-inositol adjusted for CSF in the ACC [F1,74=5.686; P=0.02] in patients compared with controls. Inositol 52-64 colony stimulating factor 2 Homo sapiens 78-81 25268566-2 2015 The effectiveness of D-chiro-inositol (DCI) treatment in improving insulin resistance in PCOS patients has been confirmed in several reports. Inositol 21-37 enoyl-CoA delta isomerase 1 Homo sapiens 39-42 25268566-2 2015 The effectiveness of D-chiro-inositol (DCI) treatment in improving insulin resistance in PCOS patients has been confirmed in several reports. Inositol 21-37 insulin Homo sapiens 67-74 25471565-9 2014 Higher amyloid-beta burden was associated with elevated mI/Cr and lower NAA/mI ratios, but not with NAA/Cr. Inositol 56-58 amyloid beta precursor protein Homo sapiens 7-19 25471565-9 2014 Higher amyloid-beta burden was associated with elevated mI/Cr and lower NAA/mI ratios, but not with NAA/Cr. Inositol 76-78 amyloid beta precursor protein Homo sapiens 7-19 25293877-6 2014 In contrast, the protective effects of lycopene in BCO2-KO but not in wild-type mice were associated with reduced hepatic endoplasmic reticulum stress-mediated unfolded protein response (ER(UPR)), through decreasing ER(UPR)-mediated protein kinase RNA-activated like kinase-eukaryotic initiation factor 2alpha activation, and inositol requiring 1alpha-X-box-binding protein 1 signaling. Inositol 326-334 beta-carotene oxygenase 2 Mus musculus 51-55 25211324-6 2014 In this study, we showed, using real-time reverse transcriptase polymerase chain reaction analysis, that INM1 is expressed in the presence of inositol, suggesting that the presence of inositol is required for INM1 transcriptional activation. Inositol 142-150 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 105-109 25211324-6 2014 In this study, we showed, using real-time reverse transcriptase polymerase chain reaction analysis, that INM1 is expressed in the presence of inositol, suggesting that the presence of inositol is required for INM1 transcriptional activation. Inositol 142-150 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 209-213 25211324-6 2014 In this study, we showed, using real-time reverse transcriptase polymerase chain reaction analysis, that INM1 is expressed in the presence of inositol, suggesting that the presence of inositol is required for INM1 transcriptional activation. Inositol 184-192 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 105-109 25211324-6 2014 In this study, we showed, using real-time reverse transcriptase polymerase chain reaction analysis, that INM1 is expressed in the presence of inositol, suggesting that the presence of inositol is required for INM1 transcriptional activation. Inositol 184-192 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 209-213 25209846-4 2014 The decreased expression level of CD155 was due to the involvement of the activating transcription factor 6 (ATF6) and inositol-requiring enzyme 1alpha (IRE1alpha) pathways. Inositol 119-127 PVR cell adhesion molecule Homo sapiens 34-39 25209846-4 2014 The decreased expression level of CD155 was due to the involvement of the activating transcription factor 6 (ATF6) and inositol-requiring enzyme 1alpha (IRE1alpha) pathways. Inositol 119-127 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 153-162 25373012-3 2014 Aim of the study was to evaluate the efficacy of natural substances such as inositol and glucomannan, and their combination in reducing glucose levels and improving insulin sensitivity in PCOS patients. Inositol 76-84 insulin Homo sapiens 165-172 25373012-7 2014 RESULTS: There was a reduction in blood glucose and insulin levels, with particular significance in the group treated with the combination of inositol-glucomannan. Inositol 142-150 insulin Homo sapiens 52-59 25301691-4 2014 Mice at 6 months of age showed an increase in myo-inositol in the hippocampus at a time when the Abeta is intracellular, but not in amygdala or cortex. Inositol 46-58 amyloid beta (A4) precursor protein Mus musculus 97-102 25120095-10 2014 In peritoneal macrophages from mice fed with an HFD for 12 weeks, macrophage Raptor deficiency decreased inflammatory gene expression, through attenuation of the inactivation of Akt and subsequent inhibition of the inositol-requiring element 1alpha/clun NH2-terminal kinase-nuclear factor kappa-light-chain-enhancer of activated B cells (IRE1alpha/JNK/NFkappaB) pathways. Inositol 215-223 regulatory associated protein of MTOR, complex 1 Mus musculus 77-83 25142592-12 2014 Here, we report that inositol-requiring protein 1 alpha (IRE1alpha), a key sensor of ER stress, is activated in cells infected with the avian coronavirus infectious bronchitis virus (IBV). Inositol 21-29 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 57-66 26484121-3 2014 Our focus was on a specific branch of UPR namely the bi-functional protein kinase/endoribonuclease inositol-requiring element 1alpha (IRE1alpha). Inositol 99-107 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 134-143 24973565-2 2014 In Saccharomyces cerevisiae, three complex SLs are present and hydrolysis of either of these species is catalyzed by the inositol phosphosphingolipid phospholipase C (Isc1p). Inositol 121-129 inositol phosphosphingolipid phospholipase Saccharomyces cerevisiae S288C 167-172 25042908-3 2014 Two inositol isomers, myo-inositol (MI) and D-chiro-inositol (DCI) have been proven to be effective in PCOS treatment, by improving insulin resistance, serum androgen levels and many features of the metabolic syndrome. Inositol 4-12 insulin Homo sapiens 132-139 25042908-3 2014 Two inositol isomers, myo-inositol (MI) and D-chiro-inositol (DCI) have been proven to be effective in PCOS treatment, by improving insulin resistance, serum androgen levels and many features of the metabolic syndrome. Inositol 22-34 insulin Homo sapiens 132-139 25042908-3 2014 Two inositol isomers, myo-inositol (MI) and D-chiro-inositol (DCI) have been proven to be effective in PCOS treatment, by improving insulin resistance, serum androgen levels and many features of the metabolic syndrome. Inositol 44-60 insulin Homo sapiens 132-139 25245999-10 2014 Thus the supplementation with inositol and resveratrol may be useful in the prevention of insulin resistance and consequently metabolic syndrome and cardiovascular diseases risk. Inositol 30-38 insulin Homo sapiens 90-97 25088227-7 2014 The level of glutamine was found to be significantly lower, whereas myo-inositol was significantly higher, in the hippocampi of Ts65Dn relative to euploid mice. Inositol 68-80 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 128-134 25138441-4 2014 bZIP60 is regulated by unconventional cytoplasmic splicing catalyzed by inositol requiring enzyme 1 (IRE1), which is located in the ER membrane. Inositol 72-80 basic region/leucine zipper motif 60 Arabidopsis thaliana 0-6 25260075-1 2014 A critical examination of the inhibition of IAPP amyloid formation by inositol stereoisomers. Inositol 70-78 islet amyloid polypeptide Homo sapiens 44-48 25260075-9 2014 We investigate the ability of inositol stereoisomers to inhibit amyloid formation by IAPP. Inositol 30-38 islet amyloid polypeptide Homo sapiens 85-89 25589933-1 2015 The kinase/endonuclease inositol requiring enzyme 1 (IRE1alpha), one of the sensors of unfolded protein accumulation in the endoplasmic reticulum that triggers the unfolded protein response (UPR), has been investigated as an anticancer target. Inositol 24-32 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 53-62 25009220-8 2014 Glucose-regulated protein 78 (GRP78) and protein kinase R-like ER protein kinase (PERK) proteins were increased at 48 h postexercise, whereas inositol-requiring enzyme 1 alpha (IRE1alpha) was elevated at 24 h and 48 h. Despite elevated protein, GRP78 and PERK mRNA was unchanged; however, IRE1alpha mRNA was increased at 24 h postexercise. Inositol 142-150 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 177-186 24863879-2 2014 Inositol-requiring enzyme-1alpha (IRE1alpha),as one of three unfolded protein sensors in UPR signaling pathways, can be activated during ER stress. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 34-43 24898153-7 2014 However, only MI has been shown to have beneficial effects on reproductive function, whereas the administration of MI/D-chiro-inositol, in the physiological plasma ratio (i.e., 40:1) ensures better clinical results, such as the reduction of insulin resistance, androgens" blood levels, cardiovascular risk and regularization of menstrual cycle with spontaneous ovulation. Inositol 118-134 insulin Homo sapiens 241-248 24932542-8 2014 Furthermore, TCDD-induced ER stress significantly promoted the activation of the PKR-like ER kinase (PERK), a sensor for the unfolded protein response (UPR), and its downstream target eukaryotic translation initiation factor 2 alpha (eIF2alpha); in contrast, TCDD did not appear to affect inositol-requiring enzyme 1 (IRE1) and activating transcription factor 6 (ATF6), two other UPR sensors. Inositol 289-297 eukaryotic translation initiation factor 2A Rattus norvegicus 234-243 25174657-7 2014 The expression of key transcription factors associated with adipocyte differentiation, such as peroxisome proliferator-activated receptor gamma (PPARgamma) and sterol regulatory element-binding protein 1c, and the expression of fatty acid synthase increased upon treatments with phytic acid and myo-inositol (P < .05). Inositol 295-307 peroxisome proliferator activated receptor gamma Mus musculus 95-143 25174657-7 2014 The expression of key transcription factors associated with adipocyte differentiation, such as peroxisome proliferator-activated receptor gamma (PPARgamma) and sterol regulatory element-binding protein 1c, and the expression of fatty acid synthase increased upon treatments with phytic acid and myo-inositol (P < .05). Inositol 295-307 fatty acid synthase Mus musculus 228-247 25174657-9 2014 In addition, mRNA levels of insulin receptor substrate 1 (IRS1), mRNA levels of glucose transporter 4, and phosphorylation of tyrosine in IRS1 increased upon phytic acid and myo-inositol treatments. Inositol 174-186 insulin receptor substrate 1 Mus musculus 28-56 25174657-9 2014 In addition, mRNA levels of insulin receptor substrate 1 (IRS1), mRNA levels of glucose transporter 4, and phosphorylation of tyrosine in IRS1 increased upon phytic acid and myo-inositol treatments. Inositol 174-186 insulin receptor substrate 1 Mus musculus 58-62 25174657-9 2014 In addition, mRNA levels of insulin receptor substrate 1 (IRS1), mRNA levels of glucose transporter 4, and phosphorylation of tyrosine in IRS1 increased upon phytic acid and myo-inositol treatments. Inositol 174-186 insulin receptor substrate 1 Mus musculus 138-142 24614687-6 2014 Integrated analysis of data identified myo-inositol related to gene clusters associated with an increase in insulin, growth factor and IGF-I signalling in CU children (P<0.05). Inositol 39-51 insulin Homo sapiens 108-115 24614687-6 2014 Integrated analysis of data identified myo-inositol related to gene clusters associated with an increase in insulin, growth factor and IGF-I signalling in CU children (P<0.05). Inositol 39-51 insulin like growth factor 1 Homo sapiens 135-140 24936061-5 2014 The mechanisms regulating inositol-requiring protein 1alpha (IRE1alpha) activation and its signaling for beta cell "adaptation," "stress response," or "apoptosis" remain to be clarified. Inositol 26-34 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 61-70 24915138-6 2014 The slight increase in the spliced form of X-box binding protein 1 (XBP1s) together with the decrease of the unspliced form (XBP1u) indicated a higher endoribonuclease activity of inositol-requiring 1alpha (IRE1alpha). Inositol 180-188 X-box binding protein 1 Homo sapiens 43-66 24915138-6 2014 The slight increase in the spliced form of X-box binding protein 1 (XBP1s) together with the decrease of the unspliced form (XBP1u) indicated a higher endoribonuclease activity of inositol-requiring 1alpha (IRE1alpha). Inositol 180-188 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 207-216 25010620-3 2014 Myo-inositol is the precursor of inositol triphosphate, a second messenger regulating many hormones such as TSH, FSH and insulin. Inositol 0-12 insulin Homo sapiens 121-128 25010620-4 2014 D-chiroinositol is synthetized by an insulin dependent epimerase that converts myo-inositol into D-chiro-inositol. Inositol 79-91 insulin Homo sapiens 37-44 25010620-4 2014 D-chiroinositol is synthetized by an insulin dependent epimerase that converts myo-inositol into D-chiro-inositol. Inositol 97-113 insulin Homo sapiens 37-44 25010620-7 2014 In these patients myo and/or D-chiro-inositol administration improves insulin sensivity while only myo-inositol is a quality marker for oocytes evaluation. Inositol 37-45 insulin Homo sapiens 70-77 24501149-1 2014 Myoinositol (MI) and d-chiroinositol (DCI) are 2 stereoisomers and insulin sensitizers. Inositol 0-11 insulin Homo sapiens 67-74 24752500-7 2014 Targeted RNA interference studies revealed that whereas ER stress signaling through inositol-requiring enzyme 1alpha (IRE1alpha) and activating transcription factor 6 (ATF6) acted cytoprotective, activation of the ER stress protein kinase PERK and subsequent expression of CHOP was pivotal for the onset of drug/TNFalpha-induced apoptosis. Inositol 84-92 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 118-127 24752500-7 2014 Targeted RNA interference studies revealed that whereas ER stress signaling through inositol-requiring enzyme 1alpha (IRE1alpha) and activating transcription factor 6 (ATF6) acted cytoprotective, activation of the ER stress protein kinase PERK and subsequent expression of CHOP was pivotal for the onset of drug/TNFalpha-induced apoptosis. Inositol 84-92 DNA damage inducible transcript 3 Homo sapiens 273-277 24752500-7 2014 Targeted RNA interference studies revealed that whereas ER stress signaling through inositol-requiring enzyme 1alpha (IRE1alpha) and activating transcription factor 6 (ATF6) acted cytoprotective, activation of the ER stress protein kinase PERK and subsequent expression of CHOP was pivotal for the onset of drug/TNFalpha-induced apoptosis. Inositol 84-92 tumor necrosis factor Homo sapiens 312-320 24884043-1 2014 Our recent DNA-microarray and proteomics studies searching for pathways affected both by chronic lithium treatment and by knockout of each of two genes (IMPA1 or Slc5a3) encoding for proteins related to inositol metabolism, indicated up-regulation of mitochondria-related genes and autophagy-related proteins in the frontal cortex. Inositol 203-211 inositol monophosphatase 1 Homo sapiens 153-158 24884043-1 2014 Our recent DNA-microarray and proteomics studies searching for pathways affected both by chronic lithium treatment and by knockout of each of two genes (IMPA1 or Slc5a3) encoding for proteins related to inositol metabolism, indicated up-regulation of mitochondria-related genes and autophagy-related proteins in the frontal cortex. Inositol 203-211 solute carrier family 5 member 3 Homo sapiens 162-168 24850492-3 2014 RESULTS: Frontal white matter myo-inositol was elevated in subjects with HIV across the age span but showed age-dependent increase in seronegative subjects, especially in APOE epsilon4+ carriers. Inositol 30-42 apolipoprotein E Homo sapiens 171-175 24850492-4 2014 In contrast, only seronegative APOE epsilon4+ subjects showed elevated myo-inositol in parietal cortex. Inositol 71-83 apolipoprotein E Homo sapiens 31-35 24850492-7 2014 Higher myo-inositol levels were associated with poorer fine motor function across all subjects, slower speed of information processing in APOE epsilon4+ subjects, and worse fluency in HIV+ APOE epsilon4+ subjects. Inositol 7-19 apolipoprotein E Homo sapiens 138-142 24850492-7 2014 Higher myo-inositol levels were associated with poorer fine motor function across all subjects, slower speed of information processing in APOE epsilon4+ subjects, and worse fluency in HIV+ APOE epsilon4+ subjects. Inositol 7-19 apolipoprotein E Homo sapiens 189-193 24582588-1 2014 The class III phosphatidylinositol 3-kinase, VPS34, phosphorylates the D3 hydroxyl of inositol generating phosphatidylinositol 3-phosphate (ptdins(3)p). Inositol 26-34 phosphatidylinositol 3-kinase catalytic subunit type 3 Homo sapiens 45-50 25054962-1 2014 OBJECTIVE: Presentation of a comprehensive body of knowledge on the role of insulin sensitizer myo-inositol in the treatment of polycystic ovary syndrome (PCOS). Inositol 95-107 insulin Homo sapiens 76-83 25054962-7 2014 This paper reviews the literature documenting the effectiveness of insulin sensitizer myo-inositol in the treatment of ovarian dysfunction, symptoms of hyperandrogenism and wide complex of symptoms of metabolic syndrome. Inositol 86-98 insulin Homo sapiens 67-74 25054962-8 2014 Six randomized controlled trials provides evidence of a positive effect of myo-inositol to normalize ovarian function, improve laboratory and clinical manifestations of hyperandrogenism and insulin resistance. Inositol 75-87 insulin Homo sapiens 190-197 24601829-2 2014 Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate the efficacy of the integrative treatment with D-chiro-inositol (DCI) (500 mg die, per os, for 12 weeks) on hormonal parameters and insulin sensitivity in a group of overweight/obese PCOS patients (body mass index; BMI > 26). Inositol 163-179 insulin Homo sapiens 51-58 24601829-2 2014 Since it has been demonstrated a high incidence of insulin resistance in PCOS patients, our study aimed to evaluate the efficacy of the integrative treatment with D-chiro-inositol (DCI) (500 mg die, per os, for 12 weeks) on hormonal parameters and insulin sensitivity in a group of overweight/obese PCOS patients (body mass index; BMI > 26). Inositol 163-179 insulin Homo sapiens 248-255 24853417-2 2014 Inositol-requiring enzyme-1a (IRE1a), as one of three unfolded protein sensors in UPR signaling pathways, can be activated during ER stress. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 30-35 24917928-3 2014 In pregnant sheep, maternal insulin infusions were used to reduce glucose supply to the fetus for both short (2-wk) and long (8-wk) durations to test the hypothesis that a maternal insulin infusion would suppress fetal mannose and inositol concentrations. Inositol 231-239 LOC105613195 Ovis aries 181-188 24610918-6 2014 The beneficial effects of 4-PBA were associated with suppressed expression of inflammatory cytokines and ER stress markers, including Grp78 and Grp94 in the activating transcription factor-6 branch, sXbp1 and Pdi in the inositol-requiring enzyme-1 branch and Atf4 in the PKR-like ER kinase branch, and reduced phosphorylation of c-Jun NH2-terminal kinase and eukaryotic translation initiation factor-2alpha in the lung. Inositol 220-228 prolyl 4-hydroxylase, beta polypeptide Mus musculus 209-212 23831342-7 2014 RESULTS: General linear model analysis demonstrated that older APOE E4 carriers had significantly higher choline/creatine and myo-inositol/creatine ratios than APOE E3 homozygotes. Inositol 126-138 apolipoprotein E Homo sapiens 63-67 23831342-8 2014 Structural equation modeling resulted in a model with an excellent goodness of fit and in which the APOE x age interaction and APOE status each had a significant effect on (1)H-MRS metabolites (choline/creatine and myo-inositol/creatine). Inositol 215-227 apolipoprotein E Homo sapiens 100-104 23831342-8 2014 Structural equation modeling resulted in a model with an excellent goodness of fit and in which the APOE x age interaction and APOE status each had a significant effect on (1)H-MRS metabolites (choline/creatine and myo-inositol/creatine). Inositol 215-227 apolipoprotein E Homo sapiens 127-131 23831342-10 2014 CONCLUSIONS: In a healthy aging normal population, choline/creatine and myo-inositol/creatine ratios were significantly increased in APOE E4 carriers, suggesting the presence of neuroinflammatory processes and greater membrane turnover in older carriers. Inositol 72-84 apolipoprotein E Homo sapiens 133-137 24606639-0 2014 Myo-inositol modulates insulin and luteinizing hormone secretion in normal weight patients with polycystic ovary syndrome. Inositol 0-12 insulin Homo sapiens 23-30 24606639-7 2014 CONCLUSION: MYO administration positively modulates insulin sensitivity in non-obese PCOS patients without compensatory hyperinsulinemia, improving hormonal parameters. Inositol 12-15 insulin Homo sapiens 52-59 24784135-6 2014 PGAP1 is a deacylase that removes an acyl-chain from the inositol of GPI anchors in the endoplasmic reticulum immediately after attachment of GPI to proteins. Inositol 57-65 post-GPI attachment to proteins inositol deacylase 1 Homo sapiens 0-5 25097470-8 2014 RESULTS: THE FOLLOWING PROFILE OF APL IGG OR IGM WAS OBTAINED FROM PATIENTS WITH LOS: cardiolipin 15/45, phosphatidic acid 41/45, phosphatidyl-choline 0/45, -ethanolamine 6/45, -glycerole 1/45 (patient with Lyme disease), -inositol 7/45, -serine 14/45, annexin V 34/45, beta2GPI 21/45, prothrombin 30/45. Inositol 223-231 coagulation factor II, thrombin Homo sapiens 286-297 24709307-7 2014 CONCLUSIONS: The two asymptomatic carriers of the heterozygous DNMT1 mutation for ADCA-DN, a late-onset neurodegenerative disease, presented with SOREMPs associated with an increase of mI in the brain, a marker of glial cell activity and density characteristic of early stages of neurodegenerative diseases. Inositol 185-187 DNA methyltransferase 1 Homo sapiens 63-68 24499450-3 2014 Two related disorders, oculocerebrorenal syndrome of Lowe (OCRL) and Dent-2 disease, are caused by mutation of the inositol 5-phosphatase OCRL1. Inositol 115-123 OCRL inositol polyphosphate-5-phosphatase Homo sapiens 23-57 24499450-3 2014 Two related disorders, oculocerebrorenal syndrome of Lowe (OCRL) and Dent-2 disease, are caused by mutation of the inositol 5-phosphatase OCRL1. Inositol 115-123 OCRL inositol polyphosphate-5-phosphatase Homo sapiens 59-63 24499450-3 2014 Two related disorders, oculocerebrorenal syndrome of Lowe (OCRL) and Dent-2 disease, are caused by mutation of the inositol 5-phosphatase OCRL1. Inositol 115-123 OCRL inositol polyphosphate-5-phosphatase Homo sapiens 138-143 24530497-3 2014 INS-2, a novel inositol glycan pseudo-disaccharide containing D-chiro-inositol and galactosamine, has been shown to function as an insulin mimetic and a putative insulin mediator. Inositol 62-78 insulin II Mus musculus 0-5 24715729-6 2014 Inactivation of HPL-2 results in an enhanced resistance to ER stress dependent on the X-box binding protein 1 (XBP-1)/inositol requiring enzyme 1 branch of the UPR and the closely related process of autophagy. Inositol 118-126 Chromo domain-containing protein Caenorhabditis elegans 16-21 24667603-2 2014 The present study investigated whether inositol 1,4,5-trisphosphate (IP3) receptor and protein kinase C (PKC) were involved in the reduction of alpha1-adrenoceptor agonist phenylephrine-evoked contraction in aortae of high fat diet-induced obese (DIO) mice. Inositol 39-47 inositol 1,4,5-triphosphate receptor 3 Mus musculus 69-82 24743743-3 2014 One key regulator that underlies cell survival and Ca(2+) homeostasis during ER stress responses is inositol-requiring enzyme 1alpha (IRE1alpha). Inositol 100-108 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 134-143 24675698-6 2014 After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1alpha and inactivation of the ERK1/2-JNK-P53 signaling were observed. Inositol 11-13 mitofusin 2 Rattus norvegicus 165-169 24675698-6 2014 After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1alpha and inactivation of the ERK1/2-JNK-P53 signaling were observed. Inositol 11-13 OPA1, mitochondrial dynamin like GTPase Rattus norvegicus 174-178 24675698-6 2014 After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1alpha and inactivation of the ERK1/2-JNK-P53 signaling were observed. Inositol 11-13 dynamin 1-like Rattus norvegicus 200-204 24675698-6 2014 After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1alpha and inactivation of the ERK1/2-JNK-P53 signaling were observed. Inositol 11-13 PPARG coactivator 1 alpha Rattus norvegicus 224-234 24675698-6 2014 After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1alpha and inactivation of the ERK1/2-JNK-P53 signaling were observed. Inositol 11-13 mitogen activated protein kinase 3 Rattus norvegicus 259-265 24675698-6 2014 After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1alpha and inactivation of the ERK1/2-JNK-P53 signaling were observed. Inositol 11-13 mitogen-activated protein kinase 8 Rattus norvegicus 266-269 24675698-6 2014 After AIT, MI-associated mitochondrial dysfunction was improved (elevated RCR and P/O and enhanced complex I, III and IV activities); in addition, increased fusion (mfn2 and OPA1), decreased fission (DRP1), elevated nuclear PGC-1alpha and inactivation of the ERK1/2-JNK-P53 signaling were observed. Inositol 11-13 Wistar clone pR53P1 p53 pseudogene Rattus norvegicus 270-273 24565834-0 2014 Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1alpha (IRE1alpha) in human colon cancer cells. Inositol 105-113 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 139-148 24565834-3 2014 In these cells, inositol-requiring enzyme1alpha (IRE1alpha) and C/EBP homologous protein (CHOP) were involved in the ER stress-autophagy pathway, and CHOP was a regulator of IRE1alpha protein expression. Inositol 16-24 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 49-58 24595108-3 2014 Global metabolite profiling revealed that mice lacking KCNE2, a K(+) channel beta subunit, showed a reduction in myo-inositol concentration in cerebrospinal fluid (CSF) but not in serum. Inositol 113-125 potassium voltage-gated channel, Isk-related subfamily, gene 2 Mus musculus 55-60 24595108-4 2014 Increased behavioral responsiveness to stress and seizure susceptibility in Kcne2(-/-) mice were alleviated by injections of myo-inositol. Inositol 125-137 potassium voltage-gated channel, Isk-related subfamily, gene 2 Mus musculus 76-81 24595108-5 2014 Suspecting a defect in myo-inositol transport, we found that KCNE2 and KCNQ1, a voltage-gated potassium channel alpha subunit, colocalized and coimmunoprecipitated with SMIT1, a Na(+)-coupled myo-inositol transporter, in the choroid plexus epithelium. Inositol 23-35 potassium voltage-gated channel, Isk-related subfamily, gene 2 Mus musculus 61-66 24595108-5 2014 Suspecting a defect in myo-inositol transport, we found that KCNE2 and KCNQ1, a voltage-gated potassium channel alpha subunit, colocalized and coimmunoprecipitated with SMIT1, a Na(+)-coupled myo-inositol transporter, in the choroid plexus epithelium. Inositol 23-35 potassium voltage-gated channel, subfamily Q, member 1 Mus musculus 71-76 24595108-5 2014 Suspecting a defect in myo-inositol transport, we found that KCNE2 and KCNQ1, a voltage-gated potassium channel alpha subunit, colocalized and coimmunoprecipitated with SMIT1, a Na(+)-coupled myo-inositol transporter, in the choroid plexus epithelium. Inositol 23-35 solute carrier family 5 (inositol transporters), member 3 Mus musculus 169-174 24595108-6 2014 Heterologous coexpression demonstrated that myo-inositol transport by SMIT1 was augmented by coexpression of KCNQ1 but was inhibited by coexpression of both KCNQ1 and KCNE2, which form a constitutively active, heteromeric K(+) channel. Inositol 44-56 solute carrier family 5 (inositol transporters), member 3 Mus musculus 70-75 24595108-6 2014 Heterologous coexpression demonstrated that myo-inositol transport by SMIT1 was augmented by coexpression of KCNQ1 but was inhibited by coexpression of both KCNQ1 and KCNE2, which form a constitutively active, heteromeric K(+) channel. Inositol 44-56 potassium voltage-gated channel, subfamily Q, member 1 Mus musculus 109-114 24595108-6 2014 Heterologous coexpression demonstrated that myo-inositol transport by SMIT1 was augmented by coexpression of KCNQ1 but was inhibited by coexpression of both KCNQ1 and KCNE2, which form a constitutively active, heteromeric K(+) channel. Inositol 44-56 potassium voltage-gated channel, subfamily Q, member 1 Mus musculus 157-162 24595108-6 2014 Heterologous coexpression demonstrated that myo-inositol transport by SMIT1 was augmented by coexpression of KCNQ1 but was inhibited by coexpression of both KCNQ1 and KCNE2, which form a constitutively active, heteromeric K(+) channel. Inositol 44-56 potassium voltage-gated channel, Isk-related subfamily, gene 2 Mus musculus 167-172 24367057-7 2014 CONCLUSION: Here we describe the first patient with deficiency of PIGW, which is involved in the addition of the acyl-chain to inositol in an early step of GPI biosynthesis. Inositol 127-135 phosphatidylinositol glycan anchor biosynthesis class W Homo sapiens 66-70 24534010-7 2014 Increased myo-inositol may represent tardive glial scarring in the prefrontal cortex, a notion supported by GFAP changes in this region after blast overexposure as well as clinical reports of increased myo-inositol in disorders of memory. Inositol 10-22 glial fibrillary acidic protein Rattus norvegicus 108-112 27485690-3 2014 As a result, highly potent 4-thiazolidinone-pyrazoline-isatin conjugates show the similarity of activity patterns with puromycin and CBU-028 and their pattern is also highly correlated with fraction of methylated CpG sites in CD34, AF5q31 and SYK. Inositol 133-136 CD34 molecule Homo sapiens 226-230 27485690-3 2014 As a result, highly potent 4-thiazolidinone-pyrazoline-isatin conjugates show the similarity of activity patterns with puromycin and CBU-028 and their pattern is also highly correlated with fraction of methylated CpG sites in CD34, AF5q31 and SYK. Inositol 133-136 AF4/FMR2 family member 4 Homo sapiens 232-238 27485690-3 2014 As a result, highly potent 4-thiazolidinone-pyrazoline-isatin conjugates show the similarity of activity patterns with puromycin and CBU-028 and their pattern is also highly correlated with fraction of methylated CpG sites in CD34, AF5q31 and SYK. Inositol 133-136 spleen associated tyrosine kinase Homo sapiens 243-246 24616733-4 2014 In plants three UPR sensors cooperate with non-identical signaling pathways: the protein kinase inositol-requiring enzyme (IRE1), the ER-membrane-associated transcription factor bZIP28, and the GTP-binding protein beta1 (AGB1). Inositol 96-104 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 123-127 24524643-1 2014 BACKGROUND: Endoplasmic reticulum stress, caused by the presence of misfolded proteins, activates the stress sensor inositol-requiring enzyme 1alpha (IRE1alpha). Inositol 116-124 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 150-159 24352657-3 2014 scyllo-Inositol is an endogenous inositol stereoisomer known to inhibit accumulation and toxicity of the amyloid-beta peptide and alpha-synuclein. Inositol 33-41 synuclein alpha Rattus norvegicus 130-145 24292008-8 2014 As well as contributing new knowledge on MAPT mutations in FTDP-17T, this is the first example of the successful generation of iNs from skin cells retrieved post-mortem. Inositol 127-130 microtubule associated protein tau Homo sapiens 41-45 24292008-8 2014 As well as contributing new knowledge on MAPT mutations in FTDP-17T, this is the first example of the successful generation of iNs from skin cells retrieved post-mortem. Inositol 127-130 microtubule associated protein tau Homo sapiens 59-66 24338370-4 2014 Compared with McGill-R-Thy1-APP females, McGill-R-Thy1-APP males had lower levels of myo-inositol and N-acetylaspartate (NAA). Inositol 85-97 Thy-1 cell surface antigen Rattus norvegicus 50-54 24357141-0 2014 Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol. Inositol 123-135 sodium voltage-gated channel alpha subunit 1 Homo sapiens 28-33 24357141-0 2014 Effects of normal aging and SCN1A risk-gene expression on brain metabolites: evidence for an association between SCN1A and myo-inositol. Inositol 123-135 sodium voltage-gated channel alpha subunit 1 Homo sapiens 113-118 24357141-3 2014 MRS studies in SCN1A-related diseases have reported striking differences in the mI concentrations between patients and controls. Inositol 80-82 sodium voltage-gated channel alpha subunit 1 Homo sapiens 15-20 24357141-5 2014 We also investigated a potential link between SCN1A and mI. Inositol 56-58 sodium voltage-gated channel alpha subunit 1 Homo sapiens 46-51 24357141-8 2014 Further, mI was higher in C allele carriers of the SCN1A variant rs10930201. Inositol 9-11 sodium voltage-gated channel alpha subunit 1 Homo sapiens 51-56 24357141-9 2014 Our results corroborated the age-related changes in metabolite concentrations, and found evidence for a link between SCN1A and frontal white matter mI in healthy subjects. Inositol 148-150 sodium voltage-gated channel alpha subunit 1 Homo sapiens 117-122 25110363-1 2014 A virtual library of 54 inositol analog mimics of In(1,4,5)P3 has been docked, scored, and ranked within the binding site of human inositol 1,4,5-trisphosphate 3-kinase A (IP3-3KA). Inositol 24-32 inositol-trisphosphate 3-kinase A Homo sapiens 131-170 24465924-2 2014 Inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) is a pivotal regulatory enzyme in inositol metabolic pathway. Inositol 82-90 inositol-tetrakisphosphate 1-kinase Homo sapiens 0-39 24465924-2 2014 Inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) is a pivotal regulatory enzyme in inositol metabolic pathway. Inositol 82-90 inositol-tetrakisphosphate 1-kinase Homo sapiens 41-46 24465924-3 2014 The objective was to assess the potential impact of the maternal ITPK1 genotypes on the inositol parameter and on the NTD risk in a NTD high-risk area in China. Inositol 88-96 inositol-tetrakisphosphate 1-kinase Homo sapiens 65-70 24269814-1 2014 In Eukarya, phosphatidylinositol (PI) is biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol. Inositol 24-32 cut like homeobox 1 Homo sapiens 61-64 24269814-1 2014 In Eukarya, phosphatidylinositol (PI) is biosynthesized from CDP-diacylglycerol (CDP-DAG) and inositol. Inositol 24-32 cut like homeobox 1 Homo sapiens 81-84 24091101-2 2014 The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2. Inositol 26-34 inositol polyphosphate-5-phosphatase D Homo sapiens 50-55 24091101-2 2014 The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes that dephosphorylate the 5 position of PI(3,4,5)P3 to produce PI(3,4)P2. Inositol 26-34 inositol polyphosphate phosphatase like 1 Homo sapiens 60-65 24236460-1 2014 PTEN (Phosphatase and Tensin homologue deleted on chromosome 10, 10q23.3) is the dominant phosphatase responsible for the dephosphorylation of the 3-position phosphate from the inositol ring of phosphatidylinositol 3,4,5 triphosphate (PIP3), and thereby directly antagonizes the actions mediated by Phosphatidylinositol-3 Kinase (PI3K). Inositol 177-185 phosphatase and tensin homolog Homo sapiens 0-4 24236460-1 2014 PTEN (Phosphatase and Tensin homologue deleted on chromosome 10, 10q23.3) is the dominant phosphatase responsible for the dephosphorylation of the 3-position phosphate from the inositol ring of phosphatidylinositol 3,4,5 triphosphate (PIP3), and thereby directly antagonizes the actions mediated by Phosphatidylinositol-3 Kinase (PI3K). Inositol 177-185 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 299-328 24189751-0 2014 Decreased myo-inositol to chiro-inositol (M/C) ratios and increased M/C epimerase activity in PCOS theca cells demonstrate increased insulin sensitivity compared to controls. Inositol 10-22 insulin Homo sapiens 133-140 24189751-1 2014 Previous studies from our and other labs have shown that insulin resistance is associated with an inositol imbalance of excess myo-inositol and deficient chiro-inositol together with a deficiency of myo-inositol to chiro-inositol epimerase in vivo and in vitro. Inositol 98-106 insulin Homo sapiens 57-64 24189751-1 2014 Previous studies from our and other labs have shown that insulin resistance is associated with an inositol imbalance of excess myo-inositol and deficient chiro-inositol together with a deficiency of myo-inositol to chiro-inositol epimerase in vivo and in vitro. Inositol 127-139 insulin Homo sapiens 57-64 24189751-1 2014 Previous studies from our and other labs have shown that insulin resistance is associated with an inositol imbalance of excess myo-inositol and deficient chiro-inositol together with a deficiency of myo-inositol to chiro-inositol epimerase in vivo and in vitro. Inositol 154-168 insulin Homo sapiens 57-64 24189751-1 2014 Previous studies from our and other labs have shown that insulin resistance is associated with an inositol imbalance of excess myo-inositol and deficient chiro-inositol together with a deficiency of myo-inositol to chiro-inositol epimerase in vivo and in vitro. Inositol 199-211 insulin Homo sapiens 57-64 24189751-4 2014 The results of these studies are the first to demonstrate that in insulin sensitive PCOS theca cells the inositol imbalance goes in the opposite direction to that observed in insulin resistant cells, and there is a decreased M/C ratio and an increased myo-inositol to chiro-inositol epimerase activity. Inositol 105-113 insulin Homo sapiens 66-73 24189751-4 2014 The results of these studies are the first to demonstrate that in insulin sensitive PCOS theca cells the inositol imbalance goes in the opposite direction to that observed in insulin resistant cells, and there is a decreased M/C ratio and an increased myo-inositol to chiro-inositol epimerase activity. Inositol 252-264 insulin Homo sapiens 66-73 24505965-1 2014 Inositol acts as a second messenger in insulin signaling pathway Literature data suggest inositol deficiency in insulin-resistant women with the polycystic ovary syndrome. Inositol 0-8 insulin Homo sapiens 39-46 24505965-1 2014 Inositol acts as a second messenger in insulin signaling pathway Literature data suggest inositol deficiency in insulin-resistant women with the polycystic ovary syndrome. Inositol 0-8 insulin Homo sapiens 112-119 24625793-6 2014 AbetaPP-PS1 mice exhibit a significant reduction in the level of NAA and increase in level of myo-inositol. Inositol 94-106 presenilin 1 Mus musculus 8-11 24876842-5 2014 Among the 91 PCOS patients treated with NAC + Inositol + folic, insulin resistance was present in 44 subjects (A) and absent in 47 (B). Inositol 46-54 insulin Homo sapiens 64-71 24297934-3 2013 Here we present evidence that the human Inositol auxotrophy 80 (Ino80) SNF2 ATPase is subject to regulation at multiple levels in the INO80 chromatin-remodeling complex. Inositol 40-48 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 Homo sapiens 71-75 24297934-3 2013 Here we present evidence that the human Inositol auxotrophy 80 (Ino80) SNF2 ATPase is subject to regulation at multiple levels in the INO80 chromatin-remodeling complex. Inositol 40-48 dynein axonemal heavy chain 8 Homo sapiens 76-82 24196957-0 2013 PAH1-encoded phosphatidate phosphatase plays a role in the growth phase- and inositol-mediated regulation of lipid synthesis in Saccharomyces cerevisiae. Inositol 77-85 phosphatidate phosphatase PAH1 Saccharomyces cerevisiae S288C 0-4 24196957-8 2013 An analysis of cells bearing PPAH1-lacZ and PPAH1-DPP1 reporter genes showed that PAH1 expression was induced throughout growth and that the induction in the stationary phase was stimulated by inositol supplementation. Inositol 193-201 bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase Saccharomyces cerevisiae S288C 50-54 24196957-8 2013 An analysis of cells bearing PPAH1-lacZ and PPAH1-DPP1 reporter genes showed that PAH1 expression was induced throughout growth and that the induction in the stationary phase was stimulated by inositol supplementation. Inositol 193-201 phosphatidate phosphatase PAH1 Saccharomyces cerevisiae S288C 30-34 23979016-1 2013 The INO80 (inositol requiring mutant 80) chromatin remodeling complex plays important roles in transcriptional regulation and DNA replication and repair, and consists of several functional protein subunits, including the critical Ino80 ATPase catalytic subunit. Inositol 11-19 INO80 complex subunit Mus musculus 4-9 23979016-1 2013 The INO80 (inositol requiring mutant 80) chromatin remodeling complex plays important roles in transcriptional regulation and DNA replication and repair, and consists of several functional protein subunits, including the critical Ino80 ATPase catalytic subunit. Inositol 11-19 INO80 complex subunit Mus musculus 230-235 24123252-1 2013 myo-Inositol monophosphatase (IMP) is an essential enzyme in the myo-inositol metabolic pathway where it primarily dephosphorylates myo-inositol 1-phosphate to maintain the cellular inositol pool which is important for many metabolic and signalling pathways in plants. Inositol 65-77 myo-inositol monophosphatase Cicer arietinum 0-28 24123252-1 2013 myo-Inositol monophosphatase (IMP) is an essential enzyme in the myo-inositol metabolic pathway where it primarily dephosphorylates myo-inositol 1-phosphate to maintain the cellular inositol pool which is important for many metabolic and signalling pathways in plants. Inositol 65-77 myo-inositol monophosphatase Cicer arietinum 30-33 24123252-1 2013 myo-Inositol monophosphatase (IMP) is an essential enzyme in the myo-inositol metabolic pathway where it primarily dephosphorylates myo-inositol 1-phosphate to maintain the cellular inositol pool which is important for many metabolic and signalling pathways in plants. Inositol 69-77 myo-inositol monophosphatase Cicer arietinum 0-28 24123252-1 2013 myo-Inositol monophosphatase (IMP) is an essential enzyme in the myo-inositol metabolic pathway where it primarily dephosphorylates myo-inositol 1-phosphate to maintain the cellular inositol pool which is important for many metabolic and signalling pathways in plants. Inositol 69-77 myo-inositol monophosphatase Cicer arietinum 30-33 24089213-8 2013 Ileitis is dependent on commensal microbiota and derives from increased intestinal epithelial cell death, inositol requiring enzyme 1alpha (IRE1alpha)-regulated NF-kappaB activation and tumour-necrosis factor signalling, which are synergistically increased when autophagy is deficient. Inositol 106-114 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 140-149 24219712-2 2013 Inositol phosphoglycan molecules have been isolated from mammalian tissues and are a major component of the intracellular mediators of insulin action. Inositol 0-8 insulin Homo sapiens 135-142 24219712-4 2013 It can be hypothesized that the reduced production of fetal insulin leads to an excretion of inositol from the intracellular to the extracellular compartment, with a consequent increase of the metabolite in plasma and urine and a decrease inside the cells. Inositol 93-101 insulin Homo sapiens 60-67 24022223-5 2013 VEGF-A signaling network analysis following liquid chromatographic separation and tandem mass spectrometry revealed proteins related to inositol/calcium signaling, nitric oxide signaling, cell survival, cell migration, and inflammatory responses. Inositol 136-144 vascular endothelial growth factor A Rattus norvegicus 0-6 24066857-1 2013 myo-Inositol oxygenase (MIOX) catalyzes the 4e(-) oxidation of myo-inositol (MI) to D-glucuronate using a substrate activated Fe(II)Fe(III) site. Inositol 63-75 myo-inositol oxygenase Homo sapiens 4-22 24066857-1 2013 myo-Inositol oxygenase (MIOX) catalyzes the 4e(-) oxidation of myo-inositol (MI) to D-glucuronate using a substrate activated Fe(II)Fe(III) site. Inositol 63-75 myo-inositol oxygenase Homo sapiens 24-28 24205197-8 2013 Activation of ER stress sensors PKR-like ER-regulated kinase (PERK) and inositol requiring protein 1alpha (IRE1alpha), and downstream effectors including eukaryotic initiation factor-2alpha (eIF2alpha), spliced X-box-binding protein 1 (sXBP1) and C/EBP homologous protein (CHOP), directly correlated with the atherogenic activity of an individual"s TGRL. Inositol 72-80 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 107-116 23711292-4 2013 We found that aged macrophages exhibited more apoptosis than young macrophages, which was accompanied by reduced activation of phosphorylated inositol-requiring enzyme-1 (p-IRE1alpha), one of the three key ER stress signal transducers. Inositol 142-150 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 173-182 23764390-1 2013 Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose. Inositol 8-16 insulin Homo sapiens 111-118 23764390-1 2013 Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose. Inositol 43-55 insulin Homo sapiens 111-118 23764390-1 2013 Several inositol isomers and in particular myo-inositol (MI) and D-chiro-inositol (DCI), were shown to possess insulin-mimetic properties and to be efficient in lowering post-prandial blood glucose. Inositol 65-81 insulin Homo sapiens 111-118 23764390-2 2013 In addition, abnormalities in inositol metabolism are associated with insulin resistance and with long term microvascular complications of diabetes, supporting a role of inositol or its derivatives in glucose metabolism. Inositol 30-38 insulin Homo sapiens 70-77 23764390-3 2013 The aim of this review is to focus on the potential benefits of a dietary supplement of myo-inositol, by far the most common inositol isomer in foodstuffs, in human disorders associated with insulin resistance (polycystic ovary syndrome, gestational diabetes mellitus or metabolic syndrome) or in prevention or treatment of some diabetic complications (neuropathy, nephropathy, cataract). Inositol 88-100 insulin Homo sapiens 191-198 23764390-3 2013 The aim of this review is to focus on the potential benefits of a dietary supplement of myo-inositol, by far the most common inositol isomer in foodstuffs, in human disorders associated with insulin resistance (polycystic ovary syndrome, gestational diabetes mellitus or metabolic syndrome) or in prevention or treatment of some diabetic complications (neuropathy, nephropathy, cataract). Inositol 92-100 insulin Homo sapiens 191-198 23764390-6 2013 Finally, the actual insights into inositol insulin-sensitizing effects will be addressed and in particular the possible role of inositol glycans as insulin second messengers. Inositol 34-42 insulin Homo sapiens 43-50 23943620-2 2013 We now report that triggering PKC-MAPK signaling by inositol deprivation or by blocking inositol-containing sphingolipid synthesis with aureobasidin A results in increased telomeric silencing regulated by the MAPK, Slt2p, and the NAD(+)-dependent deacetylase, Sir2p. Inositol 88-96 mitogen-activated serine/threonine-protein kinase SLT2 Saccharomyces cerevisiae S288C 215-220 23943620-3 2013 Consistent with the dependence on NAD(+) in Sir2p-regulated silencing, we found that inositol depletion induces the expression of BNA2, which is required for the de novo synthesis of NAD(+). Inositol 85-93 dioxygenase BNA2 Saccharomyces cerevisiae S288C 130-134 23934729-1 2013 Investigation of the intermolecular acyl-transfer reactivity in molecular crystals of myo-inositol orthoester derivatives and its correlation with crystal structures enabled us to identify the essential parameters to support efficient acyl-transfer reactions in crystals: 1) the favorable geometry of the nucleophile (-OH) and the electrophile (C-O) and 2) the molecular assembly, reinforced by C-H pi interactions, which supports a domino-type reaction in crystals. Inositol 86-98 complement C2 Homo sapiens 345-355 23942232-3 2013 Herein, we studied macrophages from the synovial fluid of RA patients and observed a significant increase in activation of inositol-requiring enzyme 1alpha (IRE1alpha), a primary unfolded protein response (UPR) transducer. Inositol 123-131 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 157-166 23596182-10 2013 Insulin infusion resulted in an increase in frontal NAA/Cr and NAA/H2O and frontal and temporal Glx/Cr and Glx/H2O and a decrease in frontal Cho/Cr and temporal Cho/H2O and myo-inositol/H2O (all P < 0.05, except temporal Glx/H2O, P = 0.054, NS) in the high-IS, but not in the low-IS, group. Inositol 173-185 insulin Homo sapiens 0-7 23596182-11 2013 Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P < 0.05). Inositol 124-136 insulin Homo sapiens 0-7 23596182-11 2013 Insulin sensitivity correlated positively with frontal NAA/Cr and NAA/H2O and temporal Glx/H2O and negatively with temporal myo-inositol/Cr and myo-inositol/H2O assessed during the second (1)H-MRS (all P < 0.05). Inositol 144-156 insulin Homo sapiens 0-7 23803178-7 2013 Membrane lipid saturation induced autophosphorylation of inositol-requiring 1alpha (IRE1alpha) and protein kinase RNA-like ER kinase, but not the conversion of activating transcription factor-6alpha to the active form. Inositol 57-65 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 84-93 23797607-4 2013 The Fura-2 Ca2+ imaging revealed that IL-1beta increased intracellular Ca2+ concentration even after removal of extracellular Ca2+, which was blocked by an inhibitor of inositol 1,4,5-trisphosphate receptors, 2-aminoethoxydiphenyl borate (2-APB, 1 muM). Inositol 169-177 interleukin 1 beta Homo sapiens 38-46 23978069-7 2013 Patients over 55 years exhibited a positive correlation between CRP and myo-inositol peak area in the left hippocampus (P < 0.05), while there was no relationship between RAGE and any metabolite (P > 0.05). Inositol 72-84 C-reactive protein Homo sapiens 64-67 23981814-1 2013 BACKGROUND: Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes. Inositol 12-20 insulin Homo sapiens 50-57 23981814-1 2013 BACKGROUND: Inositol has been reported to improve insulin sensitivity since it works as a second messenger achieving insulin-like effects on metabolic enzymes. Inositol 12-20 insulin Homo sapiens 117-124 23981814-11 2013 CONCLUSIONS: Inositol combined with alpha lipoic acid can be used as a dietary supplement in insulin-resistant patients in order to increase their insulin sensitiveness. Inositol 13-21 insulin Homo sapiens 93-100 23824185-2 2013 Here, we show that KCS1, which encodes an inositol pyrophosphate kinase, is a regulator of inositol metabolism. Inositol 42-50 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 19-23 23824185-3 2013 Deletion of KCS1, which blocks synthesis of inositol pyrophosphates on the 5-hydroxyl of the inositol ring, causes inositol auxotrophy and decreased intracellular inositol and phosphatidylinositol. Inositol 44-52 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 12-16 23824185-3 2013 Deletion of KCS1, which blocks synthesis of inositol pyrophosphates on the 5-hydroxyl of the inositol ring, causes inositol auxotrophy and decreased intracellular inositol and phosphatidylinositol. Inositol 93-101 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 12-16 23824185-3 2013 Deletion of KCS1, which blocks synthesis of inositol pyrophosphates on the 5-hydroxyl of the inositol ring, causes inositol auxotrophy and decreased intracellular inositol and phosphatidylinositol. Inositol 93-101 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 12-16 23824185-8 2013 Kcs1 is regulated in response to inositol, as Kcs1 protein levels are increased in response to inositol depletion. Inositol 33-41 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 0-4 23824185-8 2013 Kcs1 is regulated in response to inositol, as Kcs1 protein levels are increased in response to inositol depletion. Inositol 33-41 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 46-50 23824185-8 2013 Kcs1 is regulated in response to inositol, as Kcs1 protein levels are increased in response to inositol depletion. Inositol 95-103 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 0-4 23824185-8 2013 Kcs1 is regulated in response to inositol, as Kcs1 protein levels are increased in response to inositol depletion. Inositol 95-103 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 46-50 23608100-8 2013 Our results showed that N-acetylaspartate (NAA) levels increased and myo-inositol levels decreased in Tg-BDNF mice compared with Tg-PBS mice. Inositol 69-81 brain derived neurotrophic factor Mus musculus 105-109 23936155-12 2013 Plasma CD14(+) HIV DNA was associated with plasma and CSF neopterin (p = 0.023) and with MRS markers of neuronal injury (lower N-acetyl aspartate) and glial dysfunction (higher myoinositol) in multiple brain regions. Inositol 177-188 CD14 molecule Homo sapiens 7-11 23493568-6 2013 alphaXBPKD cells exhibited activation of inositol-requiring enzyme 1, an upstream activator of XBP1, leading to phosphorylation of Jun NH2-terminal kinase. Inositol 41-49 X-box binding protein 1 Mus musculus 95-99 23315172-7 2013 Our results showed that N-acetylaspartate (NAA) levels increased and myoinositol levels decreased in the BDNF group compared with the PBS group. Inositol 69-80 brain derived neurotrophic factor Mus musculus 105-109 23627280-0 2013 Binding mechanism of inositol stereoisomers to monomers and aggregates of Abeta(16-22). Inositol 21-29 amyloid beta precursor protein Homo sapiens 74-79 23504145-2 2013 Lithium decreases free inositol levels by inhibiting inositol monophosphatase 1 and myo-inositol 3-phosphate synthase (IPS). Inositol 23-31 inositol monophosphatase 1 Rattus norvegicus 53-79 23641877-6 2013 In the skeletal muscle fractions, glucose transporter type 4 (GLUT4) content in the plasma membrane increased, indicating that inositol stereoisomers stimulated GLUT4 translocation. Inositol 127-135 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 161-166 23641877-6 2013 In the skeletal muscle fractions, glucose transporter type 4 (GLUT4) content in the plasma membrane increased, indicating that inositol stereoisomers stimulated GLUT4 translocation. Inositol 127-135 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 34-60 23641877-6 2013 In the skeletal muscle fractions, glucose transporter type 4 (GLUT4) content in the plasma membrane increased, indicating that inositol stereoisomers stimulated GLUT4 translocation. Inositol 127-135 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 62-67 23684307-2 2013 Here, we report that inositol-requiring-1alpha (IRE1alpha), an ER protein that signals in the unfolded protein response (UPR), is activated to induce inflammation by binding a portion of cholera toxin as it co-opts the ER to cause disease. Inositol 21-29 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 48-57 23583400-0 2013 Ang II induces capillary formation from endothelial cells via the AT1R-dependent inositol requiring enzyme 1 pathway. Inositol 81-89 angiotensin II receptor type 1 Homo sapiens 66-70 23623749-4 2013 We also find that inositol depletion by overexpressing an arrestin-related protein Art5 partially restores the defects of cell growth and CL synthesis in the absence of Tam41. Inositol 18-26 Art5p Saccharomyces cerevisiae S288C 83-87 23225249-7 2013 The glucose-lowering effects by DCI occurred independently of insulin and were specific to the DCI stereoisomer as 200 muM myo-inositol had no effect. Inositol 123-135 enoyl-CoA delta isomerase 1 Rattus norvegicus 32-35 23165972-4 2013 RESULTS: The only differences found in brain metabolite levels between NPC1 disease model and control mice were increased myo-inositol and decreased taurine in the posterior region of the brain at the endstage of the disease. Inositol 122-134 NPC intracellular cholesterol transporter 1 Mus musculus 71-75 23529610-4 2013 METHODS AND RESULTS: We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 alpha in the endoplasmic reticulum, leading to inositol requiring enzyme 1 alpha phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Inositol 207-215 X-box binding protein 1 Mus musculus 336-340 23529610-4 2013 METHODS AND RESULTS: We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 alpha in the endoplasmic reticulum, leading to inositol requiring enzyme 1 alpha phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Inositol 282-290 X-box binding protein 1 Mus musculus 194-198 23529610-4 2013 METHODS AND RESULTS: We found that vascular endothelial cell growth factor induced the kinase insert domain receptor internalization and interaction through C-terminal domain with the unspliced XBP1 and the inositol requiring enzyme 1 alpha in the endoplasmic reticulum, leading to inositol requiring enzyme 1 alpha phosphorylation and XBP1 mRNA splicing, which was abolished by siRNA-mediated knockdown of kinase insert domain receptor. Inositol 282-290 X-box binding protein 1 Mus musculus 336-340 23529610-6 2013 Knockdown of XBP1 or inositol requiring enzyme 1 alpha decreased endothelial cell proliferation via suppression of Akt/GSK3beta phosphorylation, beta-catenin nuclear translocation, and E2F2 expression. Inositol 21-29 thymoma viral proto-oncogene 1 Mus musculus 115-118 23529610-6 2013 Knockdown of XBP1 or inositol requiring enzyme 1 alpha decreased endothelial cell proliferation via suppression of Akt/GSK3beta phosphorylation, beta-catenin nuclear translocation, and E2F2 expression. Inositol 21-29 glycogen synthase kinase 3 beta Mus musculus 119-127 23529610-6 2013 Knockdown of XBP1 or inositol requiring enzyme 1 alpha decreased endothelial cell proliferation via suppression of Akt/GSK3beta phosphorylation, beta-catenin nuclear translocation, and E2F2 expression. Inositol 21-29 catenin (cadherin associated protein), beta 1 Mus musculus 145-157 23529610-6 2013 Knockdown of XBP1 or inositol requiring enzyme 1 alpha decreased endothelial cell proliferation via suppression of Akt/GSK3beta phosphorylation, beta-catenin nuclear translocation, and E2F2 expression. Inositol 21-29 E2F transcription factor 2 Mus musculus 185-189 23443655-10 2013 Moreover, Ca(2+) release stimulated by endothelin-1 was inhibited by Ned-19, ryanodine, or xestospongin C, suggesting that NAADP-mediated Ca(2+) signals interact with both ryanodine and inositol 1,4,5-trisphosphate receptors during agonist stimulation. Inositol 186-194 endothelin 1 Rattus norvegicus 39-51 23509268-2 2013 Inositol-requiring enzyme 1 (IRE1) catalyzes the cytoplasmic splicing of mRNA encoding bZIP transcription factors to activate the UPR signaling pathway. Inositol 0-8 basic leucine-zipper 8 Arabidopsis thaliana 87-91 23403944-10 2013 Furthermore, CORM-2 inhibited X-box binding protein-1 expression, activating transcription factor-6 cleavage, and inositol-requiring enzyme (IRE)1alpha phosphorylation induced by ER stress. Inositol 114-122 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 141-151 23336594-9 2013 RESULTS: After 12 weeks of MYO administration plasma LH, PRL, T, insulin levels and LH/FSH resulted significantly reduced. Inositol 27-30 prolactin Homo sapiens 57-60 23336594-9 2013 RESULTS: After 12 weeks of MYO administration plasma LH, PRL, T, insulin levels and LH/FSH resulted significantly reduced. Inositol 27-30 insulin Homo sapiens 65-72 23373795-9 2013 USP is also part of the myo-inositol oxygenation pathway to UDP-glucuronic acid; however, free glucuronic acid does not accumulate in cells, suggesting alternative conversion pathways of this monosaccharide. Inositol 24-36 UDP-sugar pyrophosphorylase Arabidopsis thaliana 0-3 23378536-0 2013 RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1alpha)/c-Jun NH2-terminal kinase pathway. Inositol 98-106 ring finger protein 13 Homo sapiens 0-5 23378536-0 2013 RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1alpha)/c-Jun NH2-terminal kinase pathway. Inositol 98-106 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 125-134 23473031-4 2013 The canonical ER stress pathways of protein kinase RNA-like ER kinase (PERK) and inositol-requiring enzyme-1alpha (IRE1alpha) are activated within hypoxic/ischemic retinal ganglion neurons, initiating a cascade that results in angiostatic signals. Inositol 81-89 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 115-124 22843669-5 2013 Nuclear localization of dFOXO increased in D-chiro-inositol and pinitol-fed flies when compared with controls. Inositol 43-59 forkhead box, sub-group O Drosophila melanogaster 24-29 23174187-2 2013 This study focused on inositol-mediated regulation of the tandem gene pair SNA3-INO1. Inositol 22-30 Sna3p Saccharomyces cerevisiae S288C 75-79 23174187-2 2013 This study focused on inositol-mediated regulation of the tandem gene pair SNA3-INO1. Inositol 22-30 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 80-84 23174187-3 2013 While the pattern of regulation of these two genes was similar, results showed that intermediate levels of inositol repressed INO1 and induced SNA3. Inositol 107-115 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 126-130 23174187-3 2013 While the pattern of regulation of these two genes was similar, results showed that intermediate levels of inositol repressed INO1 and induced SNA3. Inositol 107-115 Sna3p Saccharomyces cerevisiae S288C 143-147 23174187-4 2013 Results also showed that inositol-mediated regulation of the SNA3 gene was not a function of its promoter but occurred from factors within the SNA3-INO1 intergenic region. Inositol 25-33 Sna3p Saccharomyces cerevisiae S288C 61-65 23174187-4 2013 Results also showed that inositol-mediated regulation of the SNA3 gene was not a function of its promoter but occurred from factors within the SNA3-INO1 intergenic region. Inositol 25-33 Sna3p Saccharomyces cerevisiae S288C 143-147 23174187-4 2013 Results also showed that inositol-mediated regulation of the SNA3 gene was not a function of its promoter but occurred from factors within the SNA3-INO1 intergenic region. Inositol 25-33 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 148-152 23081956-9 2013 For Ins, the metabolite ratio in PC3-MM2 was close to that of healthy VP (4.3 +- 2.8 vs. 6.6 +- 3.3, p = NS), but much lower than in neighboring DP (19.1 +- 1.3, P < 0.00005). Inositol 4-7 proprotein convertase subtilisin/kexin type 1 Rattus norvegicus 33-36 23467955-2 2013 Myo-inositol and D-chiro-inositol have been shown to improve insulin resistance, hyperandrogenism and to induce ovulation in PCOS women. Inositol 0-12 insulin Homo sapiens 61-68 23467955-2 2013 Myo-inositol and D-chiro-inositol have been shown to improve insulin resistance, hyperandrogenism and to induce ovulation in PCOS women. Inositol 17-33 insulin Homo sapiens 61-68 23412023-5 2013 METHODS: A new molecule with insulin-sensitizing properties, myo-inositol, has recently been successfully administered in women with PCOS. Inositol 61-73 insulin Homo sapiens 29-36 23412023-8 2013 In this article we study the effect of inositol alone and the association between myo-inositol and monacolinin K in the treatment of PCOS with insulin resistance, menstrual irregularities and hirsutism. Inositol 82-94 insulin Homo sapiens 143-150 23147779-8 2013 A-II had higher levels of glycerophosphocholine and myo-inositol than GBM. Inositol 52-64 NLR family pyrin domain containing 3 Homo sapiens 0-4 23356742-4 2013 The mammalian UPR involves BIP (or GRP78), the master sensor in the endoplasmic reticulum (ER) together with the three downstream effector branches: inositol-requiring ser/thr protein kinase/endonuclease (IRE-1), PKR-like ER resident kinase (PERK) and activating transcription factor 6 (ATF-6). Inositol 149-157 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 205-210 23356742-4 2013 The mammalian UPR involves BIP (or GRP78), the master sensor in the endoplasmic reticulum (ER) together with the three downstream effector branches: inositol-requiring ser/thr protein kinase/endonuclease (IRE-1), PKR-like ER resident kinase (PERK) and activating transcription factor 6 (ATF-6). Inositol 149-157 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 213-240 23356742-4 2013 The mammalian UPR involves BIP (or GRP78), the master sensor in the endoplasmic reticulum (ER) together with the three downstream effector branches: inositol-requiring ser/thr protein kinase/endonuclease (IRE-1), PKR-like ER resident kinase (PERK) and activating transcription factor 6 (ATF-6). Inositol 149-157 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 242-246 23356742-4 2013 The mammalian UPR involves BIP (or GRP78), the master sensor in the endoplasmic reticulum (ER) together with the three downstream effector branches: inositol-requiring ser/thr protein kinase/endonuclease (IRE-1), PKR-like ER resident kinase (PERK) and activating transcription factor 6 (ATF-6). Inositol 149-157 activating transcription factor 6 Homo sapiens 252-285 23356742-4 2013 The mammalian UPR involves BIP (or GRP78), the master sensor in the endoplasmic reticulum (ER) together with the three downstream effector branches: inositol-requiring ser/thr protein kinase/endonuclease (IRE-1), PKR-like ER resident kinase (PERK) and activating transcription factor 6 (ATF-6). Inositol 149-157 activating transcription factor 6 Homo sapiens 287-292 23223241-1 2013 Functional coupling between inositol (1,4,5)-trisphosphate receptor (IP(3)R) and ryanodine receptor (RyR) represents a critical component of intracellular Ca(2+) signaling in many excitable cells; however, the role of this mechanism in skeletal muscle remains elusive. Inositol 28-36 inositol 1,4,5-trisphosphate receptor type 1 Homo sapiens 69-75 23223241-1 2013 Functional coupling between inositol (1,4,5)-trisphosphate receptor (IP(3)R) and ryanodine receptor (RyR) represents a critical component of intracellular Ca(2+) signaling in many excitable cells; however, the role of this mechanism in skeletal muscle remains elusive. Inositol 28-36 ryanodine receptor 1 Homo sapiens 81-99 23223241-1 2013 Functional coupling between inositol (1,4,5)-trisphosphate receptor (IP(3)R) and ryanodine receptor (RyR) represents a critical component of intracellular Ca(2+) signaling in many excitable cells; however, the role of this mechanism in skeletal muscle remains elusive. Inositol 28-36 ryanodine receptor 1 Homo sapiens 101-104 23190446-2 2013 Recently, heterocyclic analogues of PIMs in which the inositol is replaced by a piperidine (aza-PIM mimics) or a tetrahydropyran moiety (oxa-PIM mimics) have been prepared by short synthetic sequences and shown to retain the biological activity of the parent PIM structures. Inositol 54-62 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 36-39 23345945-1 2013 AIM: To investigate the role of inositol-requiring enzyme 1alpha (IRE1alpha) in gut development of Xenopus lavies embryos. Inositol 32-40 endoplasmic reticulum to nucleus signaling 1 S homeolog Xenopus laevis 66-75 23184933-3 2013 Endostatin activated autophagic gene expression through XBP1 mRNA splicing in an inositol-requiring enzyme 1alpha (IRE1alpha)-dependent manner. Inositol 81-89 collagen, type XVIII, alpha 1 Mus musculus 0-10 23184933-3 2013 Endostatin activated autophagic gene expression through XBP1 mRNA splicing in an inositol-requiring enzyme 1alpha (IRE1alpha)-dependent manner. Inositol 81-89 X-box binding protein 1 Mus musculus 56-60 23184933-3 2013 Endostatin activated autophagic gene expression through XBP1 mRNA splicing in an inositol-requiring enzyme 1alpha (IRE1alpha)-dependent manner. Inositol 81-89 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 115-124 22982986-6 2013 The beneficial effects were associated with decreased endoplasmic reticulum (ER) stress response through specific inhibition of the inositol-requiring enzyme (IRE-1) signaling pathway, including its downstream effectors caspase-12 and the transcription factor C/EBP homologous protein. Inositol 132-140 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 159-164 23040614-2 2013 The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes very much involved in physiopathology and development. Inositol 26-34 inositol polyphosphate-5-phosphatase D Mus musculus 50-55 23040614-2 2013 The SH2 domain containing inositol 5-phosphatases SHIP1 and SHIP2 belong to this family of enzymes very much involved in physiopathology and development. Inositol 26-34 inositol polyphosphate phosphatase-like 1 Mus musculus 60-65 23812398-8 2013 Further, both phosphorylated inositol-requiring enzyme 1alpha (IRE1alpha) and spliced form of X-box binding protein 1 (XBP1) were decreased in the protein and the mRNA level, implying both PERK and IRE1alpha branches in UPR mechanism are controlled with hydroxynaphthoic acids. Inositol 29-37 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 63-72 23812398-8 2013 Further, both phosphorylated inositol-requiring enzyme 1alpha (IRE1alpha) and spliced form of X-box binding protein 1 (XBP1) were decreased in the protein and the mRNA level, implying both PERK and IRE1alpha branches in UPR mechanism are controlled with hydroxynaphthoic acids. Inositol 29-37 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 189-193 22612517-0 2012 Differential insulin response to myo-inositol administration in obese polycystic ovary syndrome patients. Inositol 33-45 insulin Homo sapiens 13-20 22612517-2 2012 Attention has been given to the role of inositol-phosphoglycan (IPG) mediators of insulin action and growing evidences suggest that a deficiency of D-chiro-inositol (DCI) containing IPG might be at the basis of insulin resistance, frequent in PCOS patients. Inositol 148-164 insulin Homo sapiens 82-89 22612517-2 2012 Attention has been given to the role of inositol-phosphoglycan (IPG) mediators of insulin action and growing evidences suggest that a deficiency of D-chiro-inositol (DCI) containing IPG might be at the basis of insulin resistance, frequent in PCOS patients. Inositol 148-164 insulin Homo sapiens 211-218 22612517-6 2012 In conclusion, our study supports the hypothesis that MYO administration is more effective in obese patients with high fasting insulin plasma levels. Inositol 54-57 insulin Homo sapiens 127-134 22711011-0 2012 D-chiro-inositol negatively regulates the formation of multinucleated osteoclasts by down-regulating NFATc1. Inositol 0-16 nuclear factor of activated T cells 1 Homo sapiens 101-107 22711011-7 2012 Finally, we analyzed the effect of D-chiro-inositol on OC maker expression in response to the regulation of nuclear factor of activated T cells c1 (NFATc1). Inositol 35-51 nuclear factor of activated T cells 1 Homo sapiens 148-154 22711011-10 2012 In addition, we demonstrated that D-chiro-inositol inhibits the expression of several osteoclastogenic genes by down-regulating NFATc1. Inositol 34-50 nuclear factor of activated T cells 1 Homo sapiens 128-134 22711011-12 2012 The expression of NFATc1 was significantly down-regulated by D-chiro-inositol in OCs and consequently, the expression of OC marker genes was significantly reduced. Inositol 61-77 nuclear factor of activated T cells 1 Homo sapiens 18-24 23046047-5 2012 MRS revealed significant developmental changes in the ratios of hippocampal metabolites N-acetylaspartate (NAA), myo-inositol (Ins), and taurine to total creatine (tCr) in Fmr1 KO mice compared with WT controls. Inositol 113-125 fragile X messenger ribonucleoprotein 1 Mus musculus 172-176 23232537-6 2012 Inositol is an intracellular mediator of insulin, currently much used as a therapeutic agent in PCOS. Inositol 0-8 insulin Homo sapiens 41-48 23116249-4 2012 In SLC5 symporters, three aromatic residues in TM6 (SGLT1 W289, Y290, and W291) are conserved in only those transporting sugars and inositols. Inositol 132-141 solute carrier family 5 member 1 Homo sapiens 52-57 23041190-1 2012 IRE1alpha (Inositol-requiring enzyme 1 alpha), an endoplasmic reticulum (ER)-resident sensor for mammalian unfolded protein response, is a type I transmembrane protein which has a bifunctional enzyme containing kinase and RNase domains. Inositol 11-19 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 0-9 22805178-3 2012 It is also shown that, in biofilm cells, the FLO11 transcription is accompanied by the transcription of ACC1, ACS1 and INO1 key genes in lipid biosynthesis and that biofilm formation is affected by the lack of inositol in flor medium. Inositol 210-218 Flo11p Saccharomyces cerevisiae S288C 45-50 23175745-5 2012 In addition, an ER stress sensor, INOSITOL-REQUIRING ENZYME-1b (IRE1b), was found to be required for ER stress-induced autophagy. Inositol 34-42 inositol requiring 1-1 Arabidopsis thaliana 64-69 22935424-5 2012 Salubrinal inhibited ceramide-induced inositol-requiring enzyme 1alpha (IRE1alpha)/apoptosis signal regulating kinase 1 (ASK1)/c-Jun N-terminal kinase (JNK) phosphorylation. Inositol 38-46 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 72-81 22935424-5 2012 Salubrinal inhibited ceramide-induced inositol-requiring enzyme 1alpha (IRE1alpha)/apoptosis signal regulating kinase 1 (ASK1)/c-Jun N-terminal kinase (JNK) phosphorylation. Inositol 38-46 mitogen-activated protein kinase kinase kinase 5 Homo sapiens 83-119 22800931-1 2012 scyllo-Inositol (SI) is an endogenous inositol stereoisomer known to inhibit aggregation and fibril formation of the amyloid-beta peptide (Abeta). Inositol 38-46 amyloid beta (A4) precursor protein Mus musculus 139-144 23065792-6 2012 Moreover, inhibition of amyloid-beta peptide oligomerization and fibrillization via post-weaning administration of scyllo-inositol, a naturally occurring stereoisomer of myo-inositol, rescued both structural and functional impairment of the cortical microvasculature in this Alzheimer"s disease model. Inositol 170-182 amyloid beta precursor protein Homo sapiens 24-36 22192068-8 2012 CONCLUSIONS: Myo-inositol might be considered one of the insulin-sensitizing substances in the treatment of metabolic syndrome. Inositol 13-25 insulin Homo sapiens 57-64 22973002-0 2012 Chronic suppression of inositol 1,4,5-triphosphate receptor-mediated calcium signaling in cerebellar purkinje cells alleviates pathological phenotype in spinocerebellar ataxia 2 mice. Inositol 23-31 ataxin 2 Mus musculus 153-177 23094203-10 2012 TonEBP may play an important role in transporting of inositol to fetus in placenta. Inositol 53-61 nuclear factor of activated T cells 5 Homo sapiens 0-6 22503310-8 2012 RESULTS: ALC at baseline had lower concentrations of Glu, N-acetylaspartate (NAA), choline- (Cho) and creatine-containing metabolites (Cr) than LD in the ACC, but had normal GABA and myo-inositol (mI) levels. Inositol 183-195 allantoicase Homo sapiens 9-12 22503310-8 2012 RESULTS: ALC at baseline had lower concentrations of Glu, N-acetylaspartate (NAA), choline- (Cho) and creatine-containing metabolites (Cr) than LD in the ACC, but had normal GABA and myo-inositol (mI) levels. Inositol 197-199 allantoicase Homo sapiens 9-12 22503310-11 2012 Higher cortical mI concentrations in ALC related to worse neurocognitive outcome. Inositol 16-18 allantoicase Homo sapiens 37-40 22724555-2 2012 It has recently been proposed that coffee intake might represent a risk factor for NTD, likely by interfering with the inositol signaling. Inositol 119-127 fuzzy planar cell polarity protein Homo sapiens 83-86 22876243-4 2012 One such target is the SH2 domain-containing inositol-5-phosphatase-1 (SHIP-1) which de-phosphorylates PI(3,4,5)P(3) at the D5 position of the inositol ring to create PI(3,4)P(2). Inositol 45-53 inositol polyphosphate-5-phosphatase D Homo sapiens 71-77 22704764-6 2012 Misexpression of NMM-IIA/NMM-IIB in the affected placentas continued stably to midgestation but can be prevented by folate and myoinositol supplementation. Inositol 127-138 ATPase, class II, type 9A Mus musculus 21-24 22522052-3 2012 We found that replacement of the C-terminal Arg in the natural kB2R activators bradykinin (BK) or kallidin (KD) with Lys (K(9)-BK or K(10)-KD) resulted in agonists that effectively stimulate the downstream signaling of both the kB1R and kB2R as measured by increased inositol turnover, intracellular calcium, ERK1/2 phosphorylation, arachidonic acid release and NO production. Inositol 267-275 kininogen 1 Homo sapiens 79-89 22522052-3 2012 We found that replacement of the C-terminal Arg in the natural kB2R activators bradykinin (BK) or kallidin (KD) with Lys (K(9)-BK or K(10)-KD) resulted in agonists that effectively stimulate the downstream signaling of both the kB1R and kB2R as measured by increased inositol turnover, intracellular calcium, ERK1/2 phosphorylation, arachidonic acid release and NO production. Inositol 267-275 kininogen 1 Homo sapiens 91-93 22522052-3 2012 We found that replacement of the C-terminal Arg in the natural kB2R activators bradykinin (BK) or kallidin (KD) with Lys (K(9)-BK or K(10)-KD) resulted in agonists that effectively stimulate the downstream signaling of both the kB1R and kB2R as measured by increased inositol turnover, intracellular calcium, ERK1/2 phosphorylation, arachidonic acid release and NO production. Inositol 267-275 kininogen 1 Homo sapiens 127-129 22927826-4 2012 Despite the coevolution of these genes for more than 170 million years and their divergence from higher eukaryotes, SCS3, YFT2, and the human FIT2 gene retain some common functions: expression of the yeast genes in a human embryonic kidney cell line promotes LD formation, and expression of human FIT2 in yeast rescues the inositol auxotrophy and chemical and genetic phenotypes of strains lacking SCS3. Inositol 323-331 Scs3p Saccharomyces cerevisiae S288C 116-120 22927826-4 2012 Despite the coevolution of these genes for more than 170 million years and their divergence from higher eukaryotes, SCS3, YFT2, and the human FIT2 gene retain some common functions: expression of the yeast genes in a human embryonic kidney cell line promotes LD formation, and expression of human FIT2 in yeast rescues the inositol auxotrophy and chemical and genetic phenotypes of strains lacking SCS3. Inositol 323-331 Yft2p Saccharomyces cerevisiae S288C 122-126 22927826-4 2012 Despite the coevolution of these genes for more than 170 million years and their divergence from higher eukaryotes, SCS3, YFT2, and the human FIT2 gene retain some common functions: expression of the yeast genes in a human embryonic kidney cell line promotes LD formation, and expression of human FIT2 in yeast rescues the inositol auxotrophy and chemical and genetic phenotypes of strains lacking SCS3. Inositol 323-331 fat storage inducing transmembrane protein 2 Homo sapiens 142-146 22927826-9 2012 Part of this mechanism involves a role for SCS3 in communicating changes in the ER (e.g. due to low inositol) to Opi1-regulated transcription of phospholipid biosynthetic genes. Inositol 100-108 Scs3p Saccharomyces cerevisiae S288C 43-47 22529213-10 2012 In conclusion, rat beta-cells facing mild ER stress are sensitized to IL-1beta, generating a more intense and protracted inflammatory response through inositol-requiring enzyme 1/XBP1 activation. Inositol 151-159 interleukin 1 beta Rattus norvegicus 70-78 22849963-7 2012 IP-10, MCP-4, and MIP-1beta were significantly associated with CMRs in the right basal ganglia with (1) lower concentrations of IP-10 correlating with higher N-acetyl aspartate to creatine ratios (NAA/Cr) and (2) higher concentrations of MCP-4 and MIP-1beta correlating with higher myoinositol to creatine (mI/Cr) ratios. Inositol 282-293 C-X-C motif chemokine ligand 10 Homo sapiens 128-133 22970560-7 2012 Eluant from the CarboPac MA1 analytical column passes through an electrochemical detector cell where myo-inositol is detected by pulsed amperometry using a gold electrode. Inositol 101-113 PNMA family member 1 Homo sapiens 25-28 22564531-0 2012 Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH. Inositol 51-63 solute carrier family 5 (inositol transporters), member 3 Mus musculus 31-38 22564531-0 2012 Contributions in astrocytes of SMIT1/2 and HMIT to myo-inositol uptake at different concentrations and pH. Inositol 51-63 solute carrier family 2 (facilitated glucose transporter), member 13 Mus musculus 43-47 22564531-5 2012 There are three myo-inositol transporters, the Na(+)-dependent SMIT1 and SMIT2, and HMIT, which co-transports myo-inositol with H(+). Inositol 16-28 solute carrier family 5 (inositol transporters), member 3 Mus musculus 63-68 22564531-5 2012 There are three myo-inositol transporters, the Na(+)-dependent SMIT1 and SMIT2, and HMIT, which co-transports myo-inositol with H(+). Inositol 16-28 solute carrier family 5 (sodium/glucose cotransporter), member 11 Mus musculus 73-78 22564531-5 2012 There are three myo-inositol transporters, the Na(+)-dependent SMIT1 and SMIT2, and HMIT, which co-transports myo-inositol with H(+). Inositol 16-28 solute carrier family 2 (facilitated glucose transporter), member 13 Mus musculus 84-88 22564531-9 2012 Cultured mouse astrocytes show a high-affinity/low-capacity myo-inositol uptake (V(max): 60.0 +- 3.0 pmol/min per mg protein; K(m): 16.7 +- 2.6 muM), mediated by SMIT1 and perhaps partly by SMIT2. Inositol 60-72 solute carrier family 5 (inositol transporters), member 3 Mus musculus 162-167 22564531-9 2012 Cultured mouse astrocytes show a high-affinity/low-capacity myo-inositol uptake (V(max): 60.0 +- 3.0 pmol/min per mg protein; K(m): 16.7 +- 2.6 muM), mediated by SMIT1 and perhaps partly by SMIT2. Inositol 60-72 solute carrier family 5 (sodium/glucose cotransporter), member 11 Mus musculus 190-195 22564531-11 2012 However at physiologically relevant myo-inositol concentrations most uptake is by a lower-affinity/higher-capacity uptake, mediated by HMIT (V(max): 358 +- 60 pmol/min per mg protein; K(m): 143 +- 36 muM) and determined by subtraction of SMIT-mediated from total uptake. Inositol 36-48 solute carrier family 2 (facilitated glucose transporter), member 13 Mus musculus 135-139 22564531-14 2012 At low concentration, where SMIT1/2 activity gains importance, myo-inositol uptake is reduced by ammonia-induced intracellular acidification, consistent with the transporter"s pH sensitivity reported in the literature. Inositol 63-75 solute carrier family 5 (inositol transporters), member 3 Mus musculus 28-33 22475504-9 2012 It is shown that glucose 6-phosphate isomerase and plastidial glucose 6-phosphate transport reactions are not at equilibrium, and light is shed on the pathways leading to fructose, maltose, and inositol synthesis. Inositol 194-202 glucose-6-phosphate isomerase, cytosolic Brassica napus 17-46 22538852-2 2012 Inositol-requiring enzyme 1alpha (IRE1alpha) is activated to splice X-box binding protein 1 (XBP1) mRNA, thereby increasing XBP1s protein, which in turn regulates genes responsible for protein folding and degradation during the unfolded protein response. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 34-43 22538852-2 2012 Inositol-requiring enzyme 1alpha (IRE1alpha) is activated to splice X-box binding protein 1 (XBP1) mRNA, thereby increasing XBP1s protein, which in turn regulates genes responsible for protein folding and degradation during the unfolded protein response. Inositol 0-8 X-box binding protein 1 Homo sapiens 68-91 22538852-2 2012 Inositol-requiring enzyme 1alpha (IRE1alpha) is activated to splice X-box binding protein 1 (XBP1) mRNA, thereby increasing XBP1s protein, which in turn regulates genes responsible for protein folding and degradation during the unfolded protein response. Inositol 0-8 X-box binding protein 1 Homo sapiens 93-97 22554511-7 2012 As a result, in SMIT-expressing, but not in water-injected Xenopus oocytes, myoinositol, added to the extracellular bath, generated a current (I(SMIT)), which was half maximal (K(M)) at 7.2muM myoinositol concentration. Inositol 76-87 solute carrier family 5 member 3 S homeolog Xenopus laevis 16-20 22554511-7 2012 As a result, in SMIT-expressing, but not in water-injected Xenopus oocytes, myoinositol, added to the extracellular bath, generated a current (I(SMIT)), which was half maximal (K(M)) at 7.2muM myoinositol concentration. Inositol 76-87 solute carrier family 5 member 3 S homeolog Xenopus laevis 145-149 22554511-7 2012 As a result, in SMIT-expressing, but not in water-injected Xenopus oocytes, myoinositol, added to the extracellular bath, generated a current (I(SMIT)), which was half maximal (K(M)) at 7.2muM myoinositol concentration. Inositol 194-205 solute carrier family 5 member 3 S homeolog Xenopus laevis 16-20 22554511-7 2012 As a result, in SMIT-expressing, but not in water-injected Xenopus oocytes, myoinositol, added to the extracellular bath, generated a current (I(SMIT)), which was half maximal (K(M)) at 7.2muM myoinositol concentration. Inositol 194-205 solute carrier family 5 member 3 S homeolog Xenopus laevis 145-149 22556338-3 2012 OBJECTIVE: This study aims to delineate whether changes in intestinal lipid absorption associated with loss of inositol-requiring enzyme 1beta (Ire1beta) would affect the development of hyperlipidemia and atherosclerosis in Apoe(-/-) mice. Inositol 111-119 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 144-152 22556338-3 2012 OBJECTIVE: This study aims to delineate whether changes in intestinal lipid absorption associated with loss of inositol-requiring enzyme 1beta (Ire1beta) would affect the development of hyperlipidemia and atherosclerosis in Apoe(-/-) mice. Inositol 111-119 apolipoprotein E Mus musculus 224-228 22314839-3 2012 Inositol-requiring enzyme-1a (IRE1a), as one of three unfolded protein sensors in UPR signaling pathways, senses ER unfolded proteins through an ER lumenal domain that becomes oligomerized during ER stress. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 30-35 22543816-1 2012 Yeast genes of phospholipid biosynthesis are negatively regulated by repressor protein Opi1 when precursor molecules inositol and choline (IC) are available. Inositol 117-125 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 87-91 22646706-13 2012 The substantial increases in proline, inositol and raffinose contents detected in both the wild-type and TPS1 transgenic leaves appears to be a general response of potatoes to drought stress. Inositol 38-46 alpha,alpha-trehalose-phosphate synthase (UDP-forming) TPS1 Saccharomyces cerevisiae S288C 105-109 22673525-1 2012 The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UAS(ino)) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. Inositol 209-217 Ino2p Saccharomyces cerevisiae S288C 179-183 22673525-1 2012 The regulation of phospholipid biosynthesis in Saccharomyces cerevisiae through cis-acting upstream activating sequence inositol (UAS(ino)) and trans-acting elements, such as the INO2-INO4 complex and OPI1 by inositol supplementation in growth is thoroughly studied. Inositol 209-217 Ino4p Saccharomyces cerevisiae S288C 184-188 22592687-0 2012 Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Inositol 67-83 insulin Homo sapiens 0-7 22587479-4 2012 In particular two different polyalcohol myo-inositol and D-chiro-inositol have been shown to improve insulin resistance, hyperandrogenism and to induce ovulation in PCOS women. Inositol 57-73 insulin Homo sapiens 101-108 22537350-7 2012 Suppression of SHP-1 and SHP-2 expression in KIR-CD300a Jurkat T cells with siRNA and the use of DT40 chicken B cell lines expressing CD300a and deficient in several phosphatases revealed that SHP-1, but not SHP-2 or the src homology 2 domain containing inositol 5" phosphatase SHIP, was utilized by CD300a for its inhibitory activity. Inositol 254-262 protein tyrosine phosphatase non-receptor type 6 Homo sapiens 193-198 22190709-1 2012 TonEBP/NFAT5 (the tonicity-responsive enhancer binding protein/nuclear factor of activated T cells) modulates cellular response to osmotic changes by accumulating inositol and sorbitol inside the cells. Inositol 163-171 NFAT5 Ovis aries 7-12 21894193-1 2012 Phosphatidylinositol monophosphate 5-kinase (PIP5K) catalyzes the synthesis of PI-4,5-bisphosphate (PtdIns(4,5)P(2)) by phosphorylation of PI-4-phosphate at the 5 position of the inositol ring, and is involved in regulating multiple developmental processes and stress responses. Inositol 12-20 phosphatidyl inositol monophosphate 5 kinase Arabidopsis thaliana 45-50 22649906-0 2012 AOAC SMPR 2011.007: Standard method performance requirements for myo-inositol in infant formula and adult/pediatric nutritional formula. Inositol 65-77 mannose-6-phosphate receptor, cation dependent Homo sapiens 5-9 22219379-8 2012 Finally, we find that Kar2p-sfGFP mobility significantly increases upon inositol withdrawal, which also activates the UPR, apparently independent of unfolded protein levels. Inositol 72-80 Hsp70 family ATPase KAR2 Saccharomyces cerevisiae S288C 22-27 22281492-3 2012 INO1 encodes inositol-3-phosphate synthase, which catalyzes the rate-limiting step in the synthesis of inositol, a key player in phospholipid biosynthesis. Inositol 13-21 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 0-4 22308441-1 2012 The enzyme inositol 1,3,4-trisphosphate 5/6-kinase (ITPK1) catalyzes the rate-limiting step in the formation of higher phosphorylated forms of inositol in mammalian cells. Inositol 11-19 inositol-tetrakisphosphate 1-kinase Homo sapiens 52-57 22308441-10 2012 HEK293 cells stably expressing acetylated ITPK1 had reduced levels of the higher phosphorylated forms of inositol, compared with the levels seen in cells expressing unacetylated ITPK1. Inositol 105-113 inositol-tetrakisphosphate 1-kinase Homo sapiens 42-47 22086556-5 2012 Sperm PLCzeta effects Ca(2+) release from egg intracellular stores by hydrolyzing the membrane lipid PIP(2) and consequent stimulation of the inositol 1,4,5-trisphosphate (InsP(3) ) receptor Ca(2+) -signalling pathway, leading to egg activation and early embryogenesis. Inositol 144-152 phospholipase C zeta 1 Homo sapiens 6-13 22345606-6 2012 Cellular levels of phosphatidic acid, precursor to all membrane phospholipids and the storage lipid triacylglycerol, regulates transcription of UAS(INO)-containing genes by tethering Opi1 to the nuclear/endoplasmic reticulum membrane and controlling its translocation into the nucleus, a mechanism largely controlled by inositol availability. Inositol 320-328 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 183-187 22307851-5 2012 Mutant plants were also highly sensitive to long days and accumulated, like TOR RNA interference lines, higher amounts of starch and amino acids, including proline and glutamine, while showing reduced concentrations of inositol and raffinose. Inositol 219-227 target of rapamycin Arabidopsis thaliana 76-79 22307851-8 2012 It thus appears that the LST8-1 protein has an important role in regulating amino acid accumulation and the synthesis of myo-inositol and raffinose during plant adaptation to long days. Inositol 121-133 Transducin/WD40 repeat-like superfamily protein Arabidopsis thaliana 25-31 22128176-0 2012 Dissociation of inositol-requiring enzyme (IRE1alpha)-mediated c-Jun N-terminal kinase activation from hepatic insulin resistance in conditional X-box-binding protein-1 (XBP1) knock-out mice. Inositol 16-24 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 43-52 22037186-1 2012 This study examines the extent to which the antiapoptotic Bcl-2 proteins Bcl-2 and Bcl-x(L) contribute to diabetic Ca(2+) dysregulation and vessel contractility in vascular smooth muscle cells (VSMCs) through their interaction with inositol 1,4,5-trisphosphate receptor (InsP(3)R) intracellular Ca(2+) release channels. Inositol 232-240 B cell leukemia/lymphoma 2 Mus musculus 58-63 22232265-1 2012 A malfunction in the yeast HAC1 causes the unfolding-protein response in the endoplasmic reticulum, resulting in stress-sensitive and inositol auxotrophic phenotypes. Inositol 134-142 transcription factor HAC1 Saccharomyces cerevisiae S288C 27-31 22232265-3 2012 The introduction of the truncated human CCT epsilon subunit into yeast cells of which hac1 was disrupted clearly suppressed not only its inositol auxotrophic phenotype but also its stress-sensitive phenotype. Inositol 137-145 chaperonin containing TCP1 subunit 5 Homo sapiens 40-51 22232265-3 2012 The introduction of the truncated human CCT epsilon subunit into yeast cells of which hac1 was disrupted clearly suppressed not only its inositol auxotrophic phenotype but also its stress-sensitive phenotype. Inositol 137-145 transcription factor HAC1 Saccharomyces cerevisiae S288C 86-90 22461977-0 2012 Elevated serum C-reactive protein relates to increased cerebral myoinositol levels in middle-aged adults. Inositol 64-75 C-reactive protein Homo sapiens 15-33 22461977-5 2012 Independent of age, sex and education, serum CRP was significantly related to higher cerebral myo-inositol/creatine ratio (F(4,31) = 4.74, P = 0.004), a relationship which remained unchanged after adjustment for cardiovascular risk (F(5,30) = 4.356, CRP beta = 0.322, P = 0.045). Inositol 94-106 C-reactive protein Homo sapiens 45-48 23207989-5 2012 Inositol-induced current (I(SMIT)) was determined by dual electrode voltage clamp and taken as measure for electrogenic inositol transport. Inositol 0-8 solute carrier family 5 member 3 S homeolog Xenopus laevis 28-32 21876211-3 2012 In our current study, we show that the reduction in phosphoinositide [PtdInsP (also known as PIP) and PtdInsP(2) (also known as PIP(2))] production caused by VPA is acute and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis. Inositol 248-256 prolactin induced protein Homo sapiens 93-96 21876211-3 2012 In our current study, we show that the reduction in phosphoinositide [PtdInsP (also known as PIP) and PtdInsP(2) (also known as PIP(2))] production caused by VPA is acute and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis. Inositol 248-256 prolactin induced protein Homo sapiens 128-131 21876211-3 2012 In our current study, we show that the reduction in phosphoinositide [PtdInsP (also known as PIP) and PtdInsP(2) (also known as PIP(2))] production caused by VPA is acute and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis. Inositol 283-291 prolactin induced protein Homo sapiens 93-96 21876211-3 2012 In our current study, we show that the reduction in phosphoinositide [PtdInsP (also known as PIP) and PtdInsP(2) (also known as PIP(2))] production caused by VPA is acute and dose dependent, and that this effect occurs independently of phosphatidylinositol 3-kinase (PI3K) activity, inositol recycling and inositol synthesis. Inositol 283-291 prolactin induced protein Homo sapiens 128-131 21703174-5 2012 RESULTS: The current model for JNK activation by SFA involves endoplasmic reticulum (ER) stress, which induces JNK activation through an inositol requiring enzyme 1 (IRE1alpha) Apoptosis Regulating Kinase 1 (ASK1)-dependent mechanism. Inositol 137-145 mitogen-activated protein kinase 8 Mus musculus 31-34 21703174-5 2012 RESULTS: The current model for JNK activation by SFA involves endoplasmic reticulum (ER) stress, which induces JNK activation through an inositol requiring enzyme 1 (IRE1alpha) Apoptosis Regulating Kinase 1 (ASK1)-dependent mechanism. Inositol 137-145 mitogen-activated protein kinase 8 Mus musculus 111-114 21703174-5 2012 RESULTS: The current model for JNK activation by SFA involves endoplasmic reticulum (ER) stress, which induces JNK activation through an inositol requiring enzyme 1 (IRE1alpha) Apoptosis Regulating Kinase 1 (ASK1)-dependent mechanism. Inositol 137-145 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 166-175 21703174-5 2012 RESULTS: The current model for JNK activation by SFA involves endoplasmic reticulum (ER) stress, which induces JNK activation through an inositol requiring enzyme 1 (IRE1alpha) Apoptosis Regulating Kinase 1 (ASK1)-dependent mechanism. Inositol 137-145 mitogen-activated protein kinase kinase kinase 5 Mus musculus 208-212 22025676-0 2012 Desumoylation of the endoplasmic reticulum membrane VAP family protein Scs2 by Ulp1 and SUMO regulation of the inositol synthesis pathway. Inositol 111-119 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 71-75 22025676-6 2012 Notably, impairment of either cellular sumoylation or cellular desumoylation mechanisms inhibits cell growth in the absence of inositol and exacerbates the inositol auxotrophy caused by deletion of SCS2. Inositol 156-164 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 198-202 22025676-7 2012 Mutants lacking the Ulp2 SUMO protease are the most severely affected, and this defect was traced to the mutants" impaired ability to induce transcription of INO1, which encodes the rate-limiting enzyme of inositol biosynthesis. Inositol 206-214 SUMO protease ULP2 Saccharomyces cerevisiae S288C 20-24 22025676-7 2012 Mutants lacking the Ulp2 SUMO protease are the most severely affected, and this defect was traced to the mutants" impaired ability to induce transcription of INO1, which encodes the rate-limiting enzyme of inositol biosynthesis. Inositol 206-214 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 158-162 22182244-5 2012 This study tested the ability of all yeast bHLH proteins to regulate PHO5 expression and identified inositol-mediated regulation via the Ino2p/Ino4p bHLH proteins. Inositol 100-108 Ino2p Saccharomyces cerevisiae S288C 137-142 22182244-5 2012 This study tested the ability of all yeast bHLH proteins to regulate PHO5 expression and identified inositol-mediated regulation via the Ino2p/Ino4p bHLH proteins. Inositol 100-108 Ino4p Saccharomyces cerevisiae S288C 143-147 21830089-2 2012 It is synthesized from cytidine-diphosphodiacylglycerol (CDP-DG) and myo-inositol by PtdIns synthase (PIS). Inositol 69-81 phosphatidylinositol synthase Zea mays 102-105 23285272-6 2012 Under physiological conditions, Traak-/- mice showed a particular metabolic phenotype characterized by higher levels of taurine and myo-inositol than Traak+/+ mice. Inositol 132-144 potassium channel, subfamily K, member 4 Mus musculus 32-37 23285272-10 2012 Traak-/- mice resilience to cellular edema under ischemia appears related to their physiologically high levels of myo-inositol and of taurine, an aminoacid involved in the modulation of mitochondrial activity and cell death. Inositol 114-126 potassium channel, subfamily K, member 4 Mus musculus 0-5 23094024-6 2012 The CGH results were complemented with growth studies, which demonstrated different myo-inositol, ethanolamine, and cellobiose metabolism between the chromosomal and plasmid-borne cpe-carrying strains. Inositol 84-96 cpe Clostridium perfringens 180-183 22911836-4 2012 Our metabolite analysis revealed that Cir1 influences the glycolytic pathway, ergosterol biosynthesis and inositol metabolism, which require numerous iron-dependent enzymes and play important roles in pathogenesis and antifungal sensitivity of the fungus. Inositol 106-114 corepressor interacting with RBPJ, CIR1 Homo sapiens 38-42 22403079-1 2012 Two classes of lipid phosphatases selectively dephosphorylate the 3 position of the inositol ring of phosphoinositide signaling molecules: the PTEN and the Myotubularin families. Inositol 84-92 phosphatase and tensin homolog Homo sapiens 143-147 22403079-1 2012 Two classes of lipid phosphatases selectively dephosphorylate the 3 position of the inositol ring of phosphoinositide signaling molecules: the PTEN and the Myotubularin families. Inositol 84-92 myotubularin 1 Homo sapiens 156-168 21855216-1 2011 AIM: In order to study the mechanism of abnormal macrophage (Mphi) function in pro-inflammatory cytokine changes after burn, the inositol lipid signal system and its role in tumour necrosis factor-alpha (TNF-alpha) secretion by peritoneal Mphis was observed in severely scalded mice. Inositol 129-137 tumor necrosis factor Mus musculus 204-213 21855216-10 2011 CONCLUSIONS: These results indicated that the abnormal activity of TNF-alpha of Mphis might be regulated by the inositol lipid signal system following severe burn. Inositol 112-120 tumor necrosis factor Mus musculus 67-76 21963649-6 2011 The NAA-to-myo-inositol ratio was significantly different between the treated vs. untreated SCA1 mice and demonstrated partial reversal to WT values both at early and mid-stage, consistent with the histological measures. Inositol 11-23 ataxin 1 Mus musculus 92-96 21938401-1 2011 Inositol Inpp5k (or Pps, SKIP) is a member of the inositol polyphosphate 5-phosphatases family with a poorly characterized function in vivo. Inositol 0-8 inositol polyphosphate 5-phosphatase K Mus musculus 9-15 21956977-0 2011 Effects of inositol supplementation in a cohort of mothers at risk of producing an NTD pregnancy. Inositol 11-19 fuzzy planar cell polarity protein Homo sapiens 83-86 21956977-5 2011 In humans, lower inositol blood concentration was found in pregnant women carrying NTD fetuses, whereas a periconceptional combination therapy with folic acid associated with inositol has been linked to normal live births, despite high NTD recurrence risk. Inositol 17-25 fuzzy planar cell polarity protein Homo sapiens 83-86 21729692-2 2011 The reaction catalyzed by MIPS is the first step in the biosynthesis of inositol and inositol-containing molecules that serve important roles in both eukaryotes and prokaryotes. Inositol 72-80 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 26-30 21729692-2 2011 The reaction catalyzed by MIPS is the first step in the biosynthesis of inositol and inositol-containing molecules that serve important roles in both eukaryotes and prokaryotes. Inositol 85-93 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 26-30 21940617-6 2011 RESULTS: NAA/Cr and NAA/Myo ratios are reduced in both SOD1+ subjects (39.7%, p = 0.001 and 18.0%, p = 0.02) and patients with ALS (41.2%, p < 0.001 and 24.0%, p = 0.01) compared to controls. Inositol 24-27 superoxide dismutase 1 Homo sapiens 55-59 21723843-2 2011 The endoplasmic reticulum (ER) stress response component inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) axis is essential for MM pathogenesis. Inositol 57-65 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 91-100 21723843-2 2011 The endoplasmic reticulum (ER) stress response component inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) axis is essential for MM pathogenesis. Inositol 57-65 X-box binding protein 1 Homo sapiens 102-125 21723843-2 2011 The endoplasmic reticulum (ER) stress response component inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) axis is essential for MM pathogenesis. Inositol 57-65 X-box binding protein 1 Homo sapiens 127-131 21757700-1 2011 Inositol-requiring enzyme 1alpha (IRE1alpha), an endoplasmic reticulum-resident sensor for mammalian unfolded protein response, is a bifunctional enzyme containing kinase and RNase domains critical for trans-autophosphorylation and Xbp1 mRNA splicing, respectively, in response to endoplasmic reticulum stress. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 34-43 21757700-1 2011 Inositol-requiring enzyme 1alpha (IRE1alpha), an endoplasmic reticulum-resident sensor for mammalian unfolded protein response, is a bifunctional enzyme containing kinase and RNase domains critical for trans-autophosphorylation and Xbp1 mRNA splicing, respectively, in response to endoplasmic reticulum stress. Inositol 0-8 X-box binding protein 1 Homo sapiens 232-236 21503961-11 2011 These non-catalytic properties associated to a PI phosphatase have also been reported for other enzymes of the metabolism of myo-inositol such as Ins(1,4,5)P(3) 3-kinases, inositol phosphate multikinase (IPMK), or PTEN. Inositol 125-137 inositol polyphosphate multikinase Homo sapiens 172-202 21503961-11 2011 These non-catalytic properties associated to a PI phosphatase have also been reported for other enzymes of the metabolism of myo-inositol such as Ins(1,4,5)P(3) 3-kinases, inositol phosphate multikinase (IPMK), or PTEN. Inositol 125-137 inositol polyphosphate multikinase Homo sapiens 204-208 21503961-11 2011 These non-catalytic properties associated to a PI phosphatase have also been reported for other enzymes of the metabolism of myo-inositol such as Ins(1,4,5)P(3) 3-kinases, inositol phosphate multikinase (IPMK), or PTEN. Inositol 125-137 phosphatase and tensin homolog Homo sapiens 214-218 21775630-4 2011 In contrast, this mutant was activated like wild-type Ire1 by depletion of the membrane lipid component inositol or by deletion of genes involved in lipid homeostasis. Inositol 104-112 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 54-58 21775630-5 2011 Another Ire1 mutant lacking the authentic luminal domain was up-regulated by inositol depletion as strongly as wild-type Ire1. Inositol 77-85 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 8-12 21703863-3 2011 Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Inositol 61-69 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 95-104 21703863-3 2011 Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Inositol 61-69 X-box binding protein 1 Homo sapiens 106-129 21703863-3 2011 Specifically, recent studies indicate a crucial role for the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway, the most conserved branch of the unfolded protein response (UPR), in glucose and lipid metabolism as well as in insulin function. Inositol 61-69 X-box binding protein 1 Homo sapiens 131-135 21652700-1 2011 Renal-specific oxidoreductase/myo-inositol oxygenase (RSOR/MIOX) catabolizes myo-inositol and is implicated in the pathogenesis of diabetic nephropathy. Inositol 30-42 inositol oxygenase Sus scrofa 59-63 21414183-0 2011 The effect of myoinositol supplementation on insulin resistance in patients with gestational diabetes. Inositol 14-25 insulin Homo sapiens 45-52 21414183-1 2011 AIM: To test the hypothesis that myoinositol supplementation will improve insulin sensitivity as measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance and adiponectin in women with gestational diabetes. Inositol 33-44 insulin Homo sapiens 74-81 21414183-1 2011 AIM: To test the hypothesis that myoinositol supplementation will improve insulin sensitivity as measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance and adiponectin in women with gestational diabetes. Inositol 33-44 insulin Homo sapiens 120-127 21414183-1 2011 AIM: To test the hypothesis that myoinositol supplementation will improve insulin sensitivity as measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance and adiponectin in women with gestational diabetes. Inositol 33-44 insulin Homo sapiens 120-127 21414183-1 2011 AIM: To test the hypothesis that myoinositol supplementation will improve insulin sensitivity as measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance and adiponectin in women with gestational diabetes. Inositol 33-44 adiponectin, C1Q and collagen domain containing Homo sapiens 202-213 21414183-8 2011 Adiponectin increased in the myoinositol group while it decreased in the control group (P = 0.009). Inositol 29-40 adiponectin, C1Q and collagen domain containing Homo sapiens 0-11 21414183-9 2011 CONCLUSION: Myoinositol improves insulin resistance in patients with gestational diabetes. Inositol 12-23 insulin Homo sapiens 33-40 21845803-2 2011 Myo-inositol has been classified as an insulin sensitizing agent and it is commonly used in the treatment of the Polycystic Ovary Syndrome (PCOS). Inositol 0-12 insulin Homo sapiens 39-46 21538441-2 2011 The UPR is mediated by pathways initiated by PRKR-like endoplasmic reticulum kinase, inositol-requiring 1A/X box binding protein 1, and activating transcription factor 6 (ATF6), and each of these pathways has been implicated to have a protective or pathological role in FLD. Inositol 85-93 X-box binding protein 1 Danio rerio 107-130 21534971-6 2011 bZIP11 induction results in a reprogramming of metabolism and activation of genes involved in the metabolism of trehalose and other minor carbohydrates such as myo-inositol and raffinose. Inositol 160-172 G-box binding factor 6 Arabidopsis thaliana 0-6 21539473-2 2011 Besides the direct hydrolytic regulation function over peptides, neuropeptides and peptide hormones, POP is probably involved in the regulation of the inositol pathway and participates in protein-protein interactions. Inositol 151-159 prolyl endopeptidase Homo sapiens 101-104 21394467-6 2011 Miox1/2/4/5-mutant is impaired in the utilization of myo-inositol for seedling growth. Inositol 53-65 myo-inositol oxygenase 1 Arabidopsis thaliana 0-9 21394467-8 2011 Instead, myo-inositol and metabolites produced from myo-inositol such as galactinol accumulate in the miox1/2/4/5-mutant. Inositol 9-21 myo-inositol oxygenase 1 Arabidopsis thaliana 102-111 21394467-8 2011 Instead, myo-inositol and metabolites produced from myo-inositol such as galactinol accumulate in the miox1/2/4/5-mutant. Inositol 52-64 myo-inositol oxygenase 1 Arabidopsis thaliana 102-111 21300338-0 2011 The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen. Inositol 12-20 insulin Homo sapiens 86-93 21300338-1 2011 In an attempt to evaluate the role of inositol supplementation in insulin-resistant patients with polycystic ovary syndrome (PCOS), undergoing gonadotropin ovulation induction using the low-dose step-down regimen, we conducted a prospective longitudinal study comparing the stimulation characteristics of 15 patients treated with inositol, to a cohort, matched by age and body mass index (BMI), without inositol. Inositol 38-46 insulin Homo sapiens 66-73 21514580-0 2011 The role of inositol supplementation in patients with polycystic ovary syndrome, with insulin resistance, undergoing the low-dose gonadotropin ovulation induction regimen. Inositol 12-20 insulin Homo sapiens 86-93 21682894-10 2011 Our data for the first time also demonstrate that decrements in peroxisomal function coupled with the PLP1 gene defects of PMD, result in changes in the function of membrane myo-inositol solute carriers resulting in dramatic increases in cellular myo-inositol levels. Inositol 174-186 proteolipid protein (myelin) 1 Mus musculus 102-106 21682894-10 2011 Our data for the first time also demonstrate that decrements in peroxisomal function coupled with the PLP1 gene defects of PMD, result in changes in the function of membrane myo-inositol solute carriers resulting in dramatic increases in cellular myo-inositol levels. Inositol 247-259 proteolipid protein (myelin) 1 Mus musculus 102-106 21596562-1 2011 Novel types of PKCalpha activators based on isobenzofuranone bearing a myo-inositol moiety were designed and synthesized. Inositol 71-83 protein kinase C alpha Homo sapiens 15-23 21596562-2 2011 The derivatives with bulky substituents on the myo-inositol moiety significantly activated PKCalpha, but their binding sites were not the same as that of phorbol ester. Inositol 47-59 protein kinase C alpha Homo sapiens 91-99 21590800-0 2011 Improved myo-inositol detection through Carr-Purcell PRESS: a tool for more sensitive mild cognitive impairment diagnosis. Inositol 9-21 arrestin 3 Homo sapiens 40-44 21482118-1 2011 The accumulation of unfolded proteins in the endoplasmic reticulum (ER) triggers the unfolded protein response (UPR) through the activation of specialized sensors including inositol-requiring enzyme-1alpha (IRE1alpha). Inositol 173-181 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 207-216 20960216-8 2011 Instead, expression of IMP genes was correlated with expression of the gene for myo-inositol polyphosphate 1-phosphatase (SAL1), which is involved in the myo-inositol salvage pathway, suggesting a possible salvage pathway role in seed development. Inositol 80-92 SAL1 phosphatase-like protein Arabidopsis thaliana 122-126 21372176-3 2011 Cells grown in the absence of inositol sequester Scs2p-Opi1p at the ER and derepress target genes including INO1. Inositol 30-38 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 49-54 21372176-3 2011 Cells grown in the absence of inositol sequester Scs2p-Opi1p at the ER and derepress target genes including INO1. Inositol 30-38 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 55-60 21372176-3 2011 Cells grown in the absence of inositol sequester Scs2p-Opi1p at the ER and derepress target genes including INO1. Inositol 30-38 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 108-112 21372176-4 2011 We recently reported that Yet1p and Yet3p, the yeast homologues of BAP29 and BAP31, are required for normal growth in the absence of inositol. Inositol 133-141 Yet1p Saccharomyces cerevisiae S288C 26-31 21372176-4 2011 We recently reported that Yet1p and Yet3p, the yeast homologues of BAP29 and BAP31, are required for normal growth in the absence of inositol. Inositol 133-141 Yet3p Saccharomyces cerevisiae S288C 36-41 21372176-6 2011 Yet complex binding to Scs2p-Opi1p was enhanced by inositol starvation, although the interaction between Scs2p and Opi1p was not influenced by YET1 or YET3 deletion. Inositol 51-59 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 23-28 21372176-6 2011 Yet complex binding to Scs2p-Opi1p was enhanced by inositol starvation, although the interaction between Scs2p and Opi1p was not influenced by YET1 or YET3 deletion. Inositol 51-59 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 29-34 21367863-3 2011 Gwt1p and PIG-W are inositol acyltransferases that transfer fatty acyl chains to the inositol moiety of GPI precursors in yeast and mammalian cells, respectively. Inositol 20-28 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 0-5 21367863-8 2011 The membrane topology of Gwt1p suggested that inositol acylation occurred on the luminal side of the ER membrane. Inositol 46-54 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 25-30 21320472-0 2011 The novel synthetic ether lipid inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells. Inositol 32-40 SRC proto-oncogene, non-receptor tyrosine kinase Homo sapiens 97-100 21320472-0 2011 The novel synthetic ether lipid inositol-C2-PAF inhibits phosphorylation of the tyrosine kinases Src and FAK independent of integrin activation in transformed skin cells. Inositol 32-40 protein tyrosine kinase 2 Homo sapiens 105-108 21407177-3 2011 In this study, we show that the most conserved UPR sensor inositol-requiring enzyme 1 alpha (IRE1alpha), an ER transmembrane protein kinase/endoribonuclease, is required to maintain hepatic lipid homeostasis under ER stress conditions through repressing hepatic lipid accumulation and maintaining lipoprotein secretion. Inositol 58-66 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 93-102 21246399-4 2011 Two independent mechanisms may result in fetal myo-inositol deficiency: competitive inhibition of the inositol monophosphatase1 (IMPA1)-mediated hydrolysis of inositol monophosphate by high galactose-1- phosphate levels leading to a sequestration of cellular myo-inositol as inositol monophosphate and galactitol-induced reduction in SMIT1-mediated myo-inositol transport. Inositol 47-59 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 102-127 21246399-4 2011 Two independent mechanisms may result in fetal myo-inositol deficiency: competitive inhibition of the inositol monophosphatase1 (IMPA1)-mediated hydrolysis of inositol monophosphate by high galactose-1- phosphate levels leading to a sequestration of cellular myo-inositol as inositol monophosphate and galactitol-induced reduction in SMIT1-mediated myo-inositol transport. Inositol 47-59 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 129-134 21246399-4 2011 Two independent mechanisms may result in fetal myo-inositol deficiency: competitive inhibition of the inositol monophosphatase1 (IMPA1)-mediated hydrolysis of inositol monophosphate by high galactose-1- phosphate levels leading to a sequestration of cellular myo-inositol as inositol monophosphate and galactitol-induced reduction in SMIT1-mediated myo-inositol transport. Inositol 47-59 solute carrier family 5 (inositol transporters), member 3 Mus musculus 334-339 21246399-4 2011 Two independent mechanisms may result in fetal myo-inositol deficiency: competitive inhibition of the inositol monophosphatase1 (IMPA1)-mediated hydrolysis of inositol monophosphate by high galactose-1- phosphate levels leading to a sequestration of cellular myo-inositol as inositol monophosphate and galactitol-induced reduction in SMIT1-mediated myo-inositol transport. Inositol 259-271 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 102-127 21246399-4 2011 Two independent mechanisms may result in fetal myo-inositol deficiency: competitive inhibition of the inositol monophosphatase1 (IMPA1)-mediated hydrolysis of inositol monophosphate by high galactose-1- phosphate levels leading to a sequestration of cellular myo-inositol as inositol monophosphate and galactitol-induced reduction in SMIT1-mediated myo-inositol transport. Inositol 259-271 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 129-134 21246399-7 2011 If myo-inositol deficiency is found to exist in the GALT-deficient fetal brain, then the use of myo-inositol to treat the fetus via oral supplementation of the pregnant female may warrant consideration. Inositol 3-15 galactose-1-phosphate uridyl transferase Mus musculus 52-56 21538248-7 2011 Therefore, it is possible that these genes are transcriptionally regulated by the UAS(INO) through the negative response of Ino2p to inositol. Inositol 133-141 Ino2p Saccharomyces cerevisiae S288C 124-129 21538248-8 2011 One other UAS(INO)-containing gene might be regulated by the positive response of Ino2p to 100 muM inositol. Inositol 99-107 Ino2p Saccharomyces cerevisiae S288C 82-87 21538248-10 2011 Furthermore, we identified 9 and 3 non-UAS(INO)-containing genes that are possibly regulated by the negative and positive response of Ino2p to 100 muM inositol, respectively. Inositol 151-159 Ino2p Saccharomyces cerevisiae S288C 134-139 20587749-2 2011 This has been reported to cause insulin resistance in selective tissues through activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-c-Jun NH(2)-terminal kinase (JNK) pathway, which results in the phosphorylation of the insulin receptor substrate-1 (IRS-1) at an inhibitory site and blocks insulin receptor signaling. Inositol 98-106 insulin Homo sapiens 32-39 20587749-2 2011 This has been reported to cause insulin resistance in selective tissues through activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-c-Jun NH(2)-terminal kinase (JNK) pathway, which results in the phosphorylation of the insulin receptor substrate-1 (IRS-1) at an inhibitory site and blocks insulin receptor signaling. Inositol 98-106 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 132-141 20587749-2 2011 This has been reported to cause insulin resistance in selective tissues through activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-c-Jun NH(2)-terminal kinase (JNK) pathway, which results in the phosphorylation of the insulin receptor substrate-1 (IRS-1) at an inhibitory site and blocks insulin receptor signaling. Inositol 98-106 mitogen-activated protein kinase 8 Mus musculus 172-175 20587749-2 2011 This has been reported to cause insulin resistance in selective tissues through activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-c-Jun NH(2)-terminal kinase (JNK) pathway, which results in the phosphorylation of the insulin receptor substrate-1 (IRS-1) at an inhibitory site and blocks insulin receptor signaling. Inositol 98-106 insulin receptor substrate 1 Mus musculus 230-258 20587749-2 2011 This has been reported to cause insulin resistance in selective tissues through activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-c-Jun NH(2)-terminal kinase (JNK) pathway, which results in the phosphorylation of the insulin receptor substrate-1 (IRS-1) at an inhibitory site and blocks insulin receptor signaling. Inositol 98-106 insulin receptor substrate 1 Mus musculus 260-265 20587749-2 2011 This has been reported to cause insulin resistance in selective tissues through activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-c-Jun NH(2)-terminal kinase (JNK) pathway, which results in the phosphorylation of the insulin receptor substrate-1 (IRS-1) at an inhibitory site and blocks insulin receptor signaling. Inositol 98-106 insulin Homo sapiens 230-237 21205116-1 2011 AIM: D-chiro-inositol (DCI) has been shown to prevent and reverse endothelial dysfunction in diabetic rats and rabbits. Inositol 5-21 enoyl-CoA delta isomerase 1 Rattus norvegicus 23-26 21256847-1 2011 In this work, we biochemically characterized inositol phosphosphingolipid-phospholipase C (Isc1) from the pathogenic fungus Cryptococcus neoformans. Inositol 45-53 sphingomyelin phosphodiesterase 2 Homo sapiens 91-95 21035554-7 2011 MRS assessment revealed that the myo-inositol to total creatine ratios (mIns/tCr), a measure of gliosis, were significantly higher in the hippocampus of rTg4510 mice relative to wt mice (p=0.03 for the females; p=0.005 for the males). Inositol 33-45 T cell receptor alpha variable 6-3 Mus musculus 77-80 21233347-1 2011 Upon endoplasmic reticulum (ER) stress, an endoribonuclease, inositol-requiring enzyme-1alpha, splices the precursor unspliced form of X-box-binding protein 1 messenger RNA (XBP1u mRNA) on the ER membrane to yield an active transcription factor (XBP1s), leading to the alleviation of the stress. Inositol 61-69 X-box binding protein 1 Homo sapiens 135-158 21841945-2 2011 Myo-inositol 3-phosphate synthase, encoded by the Isyna1 gene, catalyzes the synthesis of myo-inositol in cells. Inositol 90-102 inositol-3-phosphate synthase 1 Rattus norvegicus 50-56 21129877-4 2011 (1)H-MRS, however, revealed that some metabolic markers were significantly altered in FTH-Tg brains compared to wild-type control brains, such as decreases in myo-inositol and glutamine, and an increase in lactate. Inositol 159-171 ferritin heavy polypeptide 1 Mus musculus 86-89 21104417-1 2011 Repressor protein Opi1 is required to negatively regulate yeast structural genes of phospholipid biosynthesis in the presence of precursor molecules inositol and choline (IC). Inositol 149-157 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 18-22 21136082-1 2011 Inositol auxotrophy (Ino(-) phenotype) in budding yeast has classically been associated with misregulation of INO1 and other genes involved in lipid metabolism. Inositol 0-8 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 110-114 21187345-5 2011 These Slit-2 effects depended on the Ca(2+) release from internal stores through inositol (1,4,5)-triphosphate receptor channels. Inositol 81-89 slit guidance ligand 2 Homo sapiens 6-12 21146530-2 2011 The ER stress sensor inositol requiring enzyme-1beta (IRE1beta), which is specifically expressed in intestinal epithelial cells, is thought to be involved in translational repression. Inositol 21-29 endoplasmic reticulum to nucleus signaling 2 Homo sapiens 54-62 21035488-3 2011 PLCbeta1 is a key player in the regulation of nuclear inositol lipid signaling, and, as discussed above, its function could also be involved in nuclear structure because it hydrolyses PtdIns(4,5)P2, a well accepted regulator of chromatin remodelling. Inositol 54-62 phospholipase C beta 1 Homo sapiens 0-8 21586365-2 2011 The P2Y(1)(ADP), P2Y(2)(ATP/UTP), P2Y(4)(UTP), P2Y(6)(UDP), and P2Y(11)(ATP) receptors activate G(q) and therefore robustly promote inositol lipid signaling responses. Inositol 132-140 purinergic receptor P2Y1 Homo sapiens 4-10 21586365-2 2011 The P2Y(1)(ADP), P2Y(2)(ATP/UTP), P2Y(4)(UTP), P2Y(6)(UDP), and P2Y(11)(ATP) receptors activate G(q) and therefore robustly promote inositol lipid signaling responses. Inositol 132-140 pyrimidinergic receptor P2Y4 Homo sapiens 34-40 21586365-2 2011 The P2Y(1)(ADP), P2Y(2)(ATP/UTP), P2Y(4)(UTP), P2Y(6)(UDP), and P2Y(11)(ATP) receptors activate G(q) and therefore robustly promote inositol lipid signaling responses. Inositol 132-140 pyrimidinergic receptor P2Y6 Homo sapiens 47-53 22452173-0 2011 [Myoinositol--alternative treatment of insulin resistance in adolescents]. Inositol 1-12 insulin Homo sapiens 39-46 22452173-2 2011 One of the theories for insulin resistance is any deficiency in Myo-inositol. Inositol 64-76 insulin Homo sapiens 24-31 22452173-3 2011 Presumably a substitution therapy with exogenous Myo-inositol could be effective for treatment of insulin resistance and PCOS. Inositol 49-61 insulin Homo sapiens 98-105 20814537-6 2011 Myo-inositol and D-chiro-inositol have been coupled with glucose intolerance and insulin resistance in adults, and the present paper therefore suggests that IUGR is related to impaired glucose metabolism during fetal development, which may cause type 2 diabetes in adulthood. Inositol 0-12 insulin Homo sapiens 81-88 20814537-6 2011 Myo-inositol and D-chiro-inositol have been coupled with glucose intolerance and insulin resistance in adults, and the present paper therefore suggests that IUGR is related to impaired glucose metabolism during fetal development, which may cause type 2 diabetes in adulthood. Inositol 17-33 insulin Homo sapiens 81-88 20811299-1 2011 OBJECTIVE: The aim of this study was to evaluate whether myo-inositol, an insulin-sensitizing substance, may improve some features of metabolic syndrome in postmenopausal women. Inositol 57-69 insulin Homo sapiens 74-81 21266249-13 2011 The cellular response, referred to as the unfolded protein response (UPR), results in activation of three linked signal transduction pathways: PKR-like kinase (PERK), inositol requiring 1 alpha (IRE1alpha), and activating transcription factor 6alpha (ATF6alpha) (Ron, D., and Walter, P. (2007). Inositol 167-175 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 195-204 21487212-1 2011 Prolyl endopeptidase (PREP), probably acting through the inositol cycle, has been implicated in memory and learning. Inositol 57-65 prolyl endopeptidase Homo sapiens 0-20 21487212-1 2011 Prolyl endopeptidase (PREP), probably acting through the inositol cycle, has been implicated in memory and learning. Inositol 57-65 prolyl endopeptidase Homo sapiens 22-26 20623609-11 2011 The relative expression of Kir2.1 in rats in the MI and T2DM+MI group were both significantly decreased (P < 0.05); berberine recovered depressed Kir2.1 to nearly normal levels. Inositol 49-51 potassium inwardly-rectifying channel, subfamily J, member 2 Rattus norvegicus 27-33 20623609-11 2011 The relative expression of Kir2.1 in rats in the MI and T2DM+MI group were both significantly decreased (P < 0.05); berberine recovered depressed Kir2.1 to nearly normal levels. Inositol 61-63 potassium inwardly-rectifying channel, subfamily J, member 2 Rattus norvegicus 27-33 21912618-9 2011 We also show that BmGr8 functions independently in Sf9 cells and responds in a concentration-dependent manner to the polyalcohols myo-inositol and epi-inositol but not to a range of mono- and di-saccharides. Inositol 130-142 gustatory receptor 8 Bombyx mori 18-23 21912618-9 2011 We also show that BmGr8 functions independently in Sf9 cells and responds in a concentration-dependent manner to the polyalcohols myo-inositol and epi-inositol but not to a range of mono- and di-saccharides. Inositol 147-159 gustatory receptor 8 Bombyx mori 18-23 21912618-10 2011 BmGr8 is the first chemoreceptor shown to respond specifically to inositol, an important or essential nutrient for some Lepidoptera. Inositol 66-74 gustatory receptor 8 Bombyx mori 0-5 21912618-11 2011 The selectivity of BmGr8 responses is consistent with the known responses of one of the gustatory receptor neurons in the lateral styloconic sensilla of B. mori, which responds to myo-inositol and epi-inositol but not to allo-inositol. Inositol 180-192 gustatory receptor 8 Bombyx mori 19-24 21912618-11 2011 The selectivity of BmGr8 responses is consistent with the known responses of one of the gustatory receptor neurons in the lateral styloconic sensilla of B. mori, which responds to myo-inositol and epi-inositol but not to allo-inositol. Inositol 221-234 gustatory receptor 8 Bombyx mori 19-24 21887366-3 2011 There are two sodium/myo-inositol transporters (SMIT1, SMIT2) that may be responsible for regulating brain inositol levels. Inositol 25-33 solute carrier family 5 (inositol transporters), member 3 Mus musculus 48-53 21887366-3 2011 There are two sodium/myo-inositol transporters (SMIT1, SMIT2) that may be responsible for regulating brain inositol levels. Inositol 25-33 solute carrier family 5 (sodium/glucose cotransporter), member 11 Mus musculus 55-60 21625469-7 2011 Non-invasive ultrahigh field proton magnetic resonance spectroscopy revealed increased levels of NAA, myo-inositol and taurine in the aspa(lacZ/lacZ) brain. Inositol 102-114 aspartoacylase Mus musculus 134-138 19185362-9 2010 Upon multivariate analysis, methotrexate use (p=0.006) and prior mycocardial infarction (MI) (p=0.034) were associated with higher angiogenin levels; body mass index (BMI) (p=0.034) and presence of RD (p=0.029) itself predicted lower levels. Inositol 89-91 angiogenin Homo sapiens 131-141 20890752-4 2010 Substantiation by MS3 experiments showed that this neutral loss is formed after the loss of water from the precursor ion, indicating phosphate migration along the inositol ring to the glycerol backbone. Inositol 163-171 MS3 Homo sapiens 18-21 20935143-1 2010 The Saccharomyces cerevisiae INO1 gene encodes the structural enzyme inositol-3-phosphate synthase for the synthesis de novo of inositol and inositol-containing phospholipids. Inositol 69-77 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 29-33 20935143-1 2010 The Saccharomyces cerevisiae INO1 gene encodes the structural enzyme inositol-3-phosphate synthase for the synthesis de novo of inositol and inositol-containing phospholipids. Inositol 128-136 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 29-33 20935143-2 2010 The transcription of INO1 is completely derepressed in the absence of inositol and choline (I(-) C(-)). Inositol 70-78 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 21-25 21064031-10 2010 Moreover, CD154 reduced the inhibition of apoB100 secretion by HepG2 cells grown in the presence of high concentrations of OA, an effect suppressed by XBP1 mRNA silencing and in HepG2 cells expressing a dominant negative form of inositol requiring ER-to-nucleus signaling protein-1. Inositol 229-237 CD40 ligand Homo sapiens 10-15 21064031-10 2010 Moreover, CD154 reduced the inhibition of apoB100 secretion by HepG2 cells grown in the presence of high concentrations of OA, an effect suppressed by XBP1 mRNA silencing and in HepG2 cells expressing a dominant negative form of inositol requiring ER-to-nucleus signaling protein-1. Inositol 229-237 apolipoprotein B Homo sapiens 42-49 20858700-5 2010 MDA-7/IL-24 lethality was associated with pronounced endoplasmic reticulum (ER) stress induction in leukemia cell lines and primary AML blasts, manifested by the accumulation of growth arrest and DNA damage-inducible protein 34 (GADD34), 78-kDa glucose-regulated protein (GRP78)/BiP, inositol-requiring enzyme 1alpha (IRE1alpha), and eukaryotic initiation factor 2alpha phosphorylation. Inositol 284-292 interleukin 24 Homo sapiens 0-5 20858700-5 2010 MDA-7/IL-24 lethality was associated with pronounced endoplasmic reticulum (ER) stress induction in leukemia cell lines and primary AML blasts, manifested by the accumulation of growth arrest and DNA damage-inducible protein 34 (GADD34), 78-kDa glucose-regulated protein (GRP78)/BiP, inositol-requiring enzyme 1alpha (IRE1alpha), and eukaryotic initiation factor 2alpha phosphorylation. Inositol 284-292 interleukin 24 Homo sapiens 6-11 20800640-6 2010 Hence, dysfunction of inositol caused by IMPA2 irregularity may contribute to the pathophysiology of BPD. Inositol 22-30 inositol monophosphatase 2 Homo sapiens 41-46 20810657-0 2010 A key role for the phosphorylation of Ser440 by the cyclic AMP-dependent protein kinase in regulating the activity of the Src homology 2 domain-containing Inositol 5"-phosphatase (SHIP1). Inositol 155-163 inositol polyphosphate-5-phosphatase D Homo sapiens 180-185 19896870-1 2010 Myo-inositol oxygenase (MIOX) is the first and rate-limiting enzyme in myo-inositol (MI) metabolism pathway. Inositol 71-83 myo-inositol oxygenase Homo sapiens 0-22 19896870-1 2010 Myo-inositol oxygenase (MIOX) is the first and rate-limiting enzyme in myo-inositol (MI) metabolism pathway. Inositol 71-83 myo-inositol oxygenase Homo sapiens 24-28 20713024-7 2010 The putative gliosis marker myo-inositol was higher than controls in the vermis and pons in AOA2 and in the vermis in FRDA. Inositol 28-40 frataxin Homo sapiens 118-122 20876729-8 2010 The observed frequency and pattern of loss indicate that INPP5A, a negative regulator of inositol signaling, may play a role in development and progression of cutaneous SCC tumors. Inositol 89-97 inositol polyphosphate-5-phosphatase A Homo sapiens 57-63 20547660-8 2010 The observed increases in expression of IMPA1 highlight a protective role for inositol within various eel tissues following SW acclimation. Inositol 78-86 inositol monophosphatase 1 Homo sapiens 40-45 20670940-6 2010 uPrP is glycosylated and carries an anchor which, at variance with that of cellular PrP, lacks the inositol-associated phospholipid moiety, indicating that uPrP is probably shed from the cell surface. Inositol 99-107 prion protein Homo sapiens 1-4 20719962-3 2010 Overexpression of Spry1 and Spry2 was associated with decreased PLCgamma phosphorylation and decreased PLCgamma activity as measured by production of inositol (1,4,5)-triphosphate (IP(3)) and diacylglycerol, whereas cells deficient for Spry1 or Spry1, -2, and -4 showed increased production of IP(3) at baseline and further increased in response to growth factor signals. Inositol 150-158 sprouty RTK signaling antagonist 1 Mus musculus 18-23 20719962-3 2010 Overexpression of Spry1 and Spry2 was associated with decreased PLCgamma phosphorylation and decreased PLCgamma activity as measured by production of inositol (1,4,5)-triphosphate (IP(3)) and diacylglycerol, whereas cells deficient for Spry1 or Spry1, -2, and -4 showed increased production of IP(3) at baseline and further increased in response to growth factor signals. Inositol 150-158 sprouty RTK signaling antagonist 2 Mus musculus 28-33 20718038-1 2010 The tumor suppressor, phosphatase, and tensin homologue deleted on chromosome 10 (PTEN), is a phosphoinositide (PI) phosphatase specific for the 3-position of the inositol ring. Inositol 163-171 phosphatase and tensin homolog Homo sapiens 82-86 20584908-2 2010 We have shown previously that inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) plays a critical role in stimulation of NHE3 in response to elevated intracellular Ca(2+) concentration ([Ca(2+)](i)). Inositol 30-38 adenosylhomocysteinase like 1 Homo sapiens 126-131 20584908-2 2010 We have shown previously that inositol 1,4,5-triphosphate receptor-binding protein released with inositol 1,4,5-triphosphate (IRBIT) plays a critical role in stimulation of NHE3 in response to elevated intracellular Ca(2+) concentration ([Ca(2+)](i)). Inositol 30-38 solute carrier family 9 member A3 Homo sapiens 173-177 20399219-1 2010 There is evidence that inositol isomers may help protect against formation of toxic fibrils of Abeta fragments in Alzheimer"s disease mouse models. Inositol 23-31 amyloid beta (A4) precursor protein Mus musculus 95-100 20805522-4 2010 RESULTS: Symptomatic MAPT mutation carriers were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) ratio, an index of neuronal integrity, increased myoinositol (mI)/Cr ratio, a possible marker for glial activity, decreased NAA/mI, and hippocampal atrophy (p < 0.001). Inositol 161-172 regulator of microtubule dynamics 1 Homo sapiens 21-25 20805522-4 2010 RESULTS: Symptomatic MAPT mutation carriers were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) ratio, an index of neuronal integrity, increased myoinositol (mI)/Cr ratio, a possible marker for glial activity, decreased NAA/mI, and hippocampal atrophy (p < 0.001). Inositol 174-176 regulator of microtubule dynamics 1 Homo sapiens 21-25 20805522-4 2010 RESULTS: Symptomatic MAPT mutation carriers were characterized by decreased N-acetylaspartate/creatine (NAA/Cr) ratio, an index of neuronal integrity, increased myoinositol (mI)/Cr ratio, a possible marker for glial activity, decreased NAA/mI, and hippocampal atrophy (p < 0.001). Inositol 240-242 regulator of microtubule dynamics 1 Homo sapiens 21-25 20805522-5 2010 Whereas presymptomatic MAPT mutation carriers had elevated mI/Cr and decreased NAA/mI (p < 0.001), NAA/Cr levels and hippocampal volumes were not different from controls. Inositol 59-61 regulator of microtubule dynamics 1 Homo sapiens 23-27 20805522-5 2010 Whereas presymptomatic MAPT mutation carriers had elevated mI/Cr and decreased NAA/mI (p < 0.001), NAA/Cr levels and hippocampal volumes were not different from controls. Inositol 83-85 regulator of microtubule dynamics 1 Homo sapiens 23-27 20805522-8 2010 CONCLUSION: (1)H MRS metabolite abnormalities characterized by an elevated mI/Cr and decreased NAA/mI are present several years before the onset of symptoms in MAPT mutation carriers. Inositol 99-101 regulator of microtubule dynamics 1 Homo sapiens 160-164 20538496-8 2010 We show that, while each of the compounds binds with the inositol headgroup inserting into the proposed active site of the PTEN phosphatase domain, hydrogen bonding restrictions lead to distinct binding geometries for ligand pairs of opposite chirality. Inositol 57-65 phosphatase and tensin homolog Homo sapiens 123-127 20451895-9 2010 CONCLUSION: Folic acid supplementation alone or with myoinositol prevented alcohol potentiation of Wnt/beta-catenin signaling that allowed normal gene activation and cardiogenesis. Inositol 53-64 catenin (cadherin associated protein), beta 1 Mus musculus 103-115 20711567-0 2010 Stimulating effect of external Myo-inositol on the expression of mutant forms of aquaporin 2. Inositol 31-43 aquaporin 2 S homeolog Xenopus laevis 81-92 20567601-6 2010 Further studies demonstrated that PO is a negative regulator of inositol(1,4,5)trisphosphate (IP(3)) synthesis, a Li(+) sensitive intracellular signal. Inositol 64-72 prolyl endopeptidase Homo sapiens 34-36 20378542-0 2010 Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. Inositol 141-149 Yet1p Saccharomyces cerevisiae S288C 0-5 20378542-0 2010 Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. Inositol 141-149 Yet3p Saccharomyces cerevisiae S288C 10-15 20378542-0 2010 Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. Inositol 141-149 B cell receptor associated protein 29 Homo sapiens 39-44 20378542-0 2010 Yet1p and Yet3p, the yeast homologs of BAP29 and BAP31, interact with the endoplasmic reticulum translocation apparatus and are required for inositol prototrophy. Inositol 141-149 B cell receptor associated protein 31 Homo sapiens 49-54 19744483-4 2010 Studies on the interaction between Abeta and cell membranes led to the discovery that inositol, the head group of phosphatidylinositol, inhibits fibrillogenesis. Inositol 86-94 amyloid beta (A4) precursor protein Mus musculus 35-40 20470193-8 2010 Increased phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) and induced mRNA splicing of X-box binding protein 1 (XBP1) suggested that PERK (interferon-induced double-stranded RNA-activated protein kinase (PRKR) -like endoplasmic reticulum kinase) and IRE1 (inositol requirement 1) signal transduction pathways were involved in this kind of ER stress. Inositol 282-290 X-box binding protein 1 Rattus norvegicus 113-136 20470193-8 2010 Increased phosphorylation of eukaryotic translation initiation factor 2 (eIF2alpha) and induced mRNA splicing of X-box binding protein 1 (XBP1) suggested that PERK (interferon-induced double-stranded RNA-activated protein kinase (PRKR) -like endoplasmic reticulum kinase) and IRE1 (inositol requirement 1) signal transduction pathways were involved in this kind of ER stress. Inositol 282-290 X-box binding protein 1 Rattus norvegicus 138-142 20162531-7 2010 The results showed that expression of CIT2-lacZ reporter was induced in a rho(0) strain by the presence of inositol via the Ino2p and Ino4p bHLH proteins, which are known regulators of phospholipid synthesis. Inositol 107-115 citrate (Si)-synthase CIT2 Saccharomyces cerevisiae S288C 38-42 20162531-7 2010 The results showed that expression of CIT2-lacZ reporter was induced in a rho(0) strain by the presence of inositol via the Ino2p and Ino4p bHLH proteins, which are known regulators of phospholipid synthesis. Inositol 107-115 Ino2p Saccharomyces cerevisiae S288C 124-129 20162531-7 2010 The results showed that expression of CIT2-lacZ reporter was induced in a rho(0) strain by the presence of inositol via the Ino2p and Ino4p bHLH proteins, which are known regulators of phospholipid synthesis. Inositol 107-115 Ino4p Saccharomyces cerevisiae S288C 134-138 20162531-8 2010 Promoter mutations revealed that inositol induction required a distal E-box in the CIT2 promoter. Inositol 33-41 citrate (Si)-synthase CIT2 Saccharomyces cerevisiae S288C 83-87 20689743-7 2010 Expression of ITR genes in a Saccharomyces cerevisiae itr1 itr2 mutant lacking inositol transport can complement the slow-growth phenotype of this strain, confirming that ITR genes are bona fide inositol transporters. Inositol 79-87 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 54-63 20689743-7 2010 Expression of ITR genes in a Saccharomyces cerevisiae itr1 itr2 mutant lacking inositol transport can complement the slow-growth phenotype of this strain, confirming that ITR genes are bona fide inositol transporters. Inositol 195-203 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 54-63 20237065-1 2010 Recent studies have linked the unfolded protein response (UPR), in particular the inositol-requiring, endoplasmic reticulum-to-nucleus signaling protein 1alpha (IRE1alpha)-X-box-binding protein-1 (XBP1) branch of the UPR, to the regulation of lipogenesis and hepatic steatosis. Inositol 82-90 X-box binding protein 1 Rattus norvegicus 172-195 20237065-1 2010 Recent studies have linked the unfolded protein response (UPR), in particular the inositol-requiring, endoplasmic reticulum-to-nucleus signaling protein 1alpha (IRE1alpha)-X-box-binding protein-1 (XBP1) branch of the UPR, to the regulation of lipogenesis and hepatic steatosis. Inositol 82-90 X-box binding protein 1 Rattus norvegicus 197-201 20156067-0 2010 Uncoupling between insulin and release of a D-chiro-inositol-containing inositolphosphoglycan mediator of insulin action in obese women With polycystic ovary syndrome. Inositol 44-60 insulin Homo sapiens 106-113 20156067-1 2010 BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) manifest impaired insulin-stimulated release of a d-chiro-inositol-containing inositolphosphoglycan (DCI-IPG) insulin mediator during oral glucose tolerance testing (OGTT), which appears to be restored by the administration of metformin. Inositol 112-128 insulin Homo sapiens 80-87 20156067-1 2010 BACKGROUND: Obese women with polycystic ovary syndrome (PCOS) manifest impaired insulin-stimulated release of a d-chiro-inositol-containing inositolphosphoglycan (DCI-IPG) insulin mediator during oral glucose tolerance testing (OGTT), which appears to be restored by the administration of metformin. Inositol 112-128 insulin Homo sapiens 172-179 20371724-1 2010 Increased levels of misfolded polypeptides in the endoplasmic reticulum (ER) triggers the dissociation of glucose-regulated protein 78 (GRP78) from the three transmembrane ER-stress mediators, i.e., protein kinase RNA-like ER kinase (PERK), activating transcription factor-6 (ATF6), and inositol-requiring enzyme 1alpha, which results in the adaptive unfolded protein response (UPR). Inositol 287-295 heat shock protein family A (Hsp70) member 5 Homo sapiens 106-134 20371724-1 2010 Increased levels of misfolded polypeptides in the endoplasmic reticulum (ER) triggers the dissociation of glucose-regulated protein 78 (GRP78) from the three transmembrane ER-stress mediators, i.e., protein kinase RNA-like ER kinase (PERK), activating transcription factor-6 (ATF6), and inositol-requiring enzyme 1alpha, which results in the adaptive unfolded protein response (UPR). Inositol 287-295 heat shock protein family A (Hsp70) member 5 Homo sapiens 136-141 20371724-1 2010 Increased levels of misfolded polypeptides in the endoplasmic reticulum (ER) triggers the dissociation of glucose-regulated protein 78 (GRP78) from the three transmembrane ER-stress mediators, i.e., protein kinase RNA-like ER kinase (PERK), activating transcription factor-6 (ATF6), and inositol-requiring enzyme 1alpha, which results in the adaptive unfolded protein response (UPR). Inositol 287-295 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 199-232 20146926-1 2010 Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 34-43 20146926-1 2010 Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Inositol 0-8 X-box binding protein 1 Homo sapiens 151-174 20146926-1 2010 Inositol requiring enzyme-1alpha (IRE1alpha) is an ER-located transmembrane RNase whose activation leads to the production of the transcription factor X-box binding protein 1 (XBP1). Inositol 0-8 X-box binding protein 1 Homo sapiens 176-180 20007910-5 2010 Moreover, undifferentiated cells express inositol-requiring enzyme 1beta (IRE1beta), a protein that posttranscriptionally degrades MTP mRNA, and its expression substantially decreases during differentiation, contributing to MTP induction. Inositol 41-49 endoplasmic reticulum to nucleus signaling 2 Homo sapiens 74-82 20007910-5 2010 Moreover, undifferentiated cells express inositol-requiring enzyme 1beta (IRE1beta), a protein that posttranscriptionally degrades MTP mRNA, and its expression substantially decreases during differentiation, contributing to MTP induction. Inositol 41-49 microsomal triglyceride transfer protein Homo sapiens 131-134 20007910-5 2010 Moreover, undifferentiated cells express inositol-requiring enzyme 1beta (IRE1beta), a protein that posttranscriptionally degrades MTP mRNA, and its expression substantially decreases during differentiation, contributing to MTP induction. Inositol 41-49 microsomal triglyceride transfer protein Homo sapiens 224-227 20054697-2 2010 We investigated the factors required for activation of yeast phospholipid biosynthetic genes, depending on activator protein Ino2 which binds to the inositol/choline-responsive element (ICRE) upstream promoter motif together with its partner protein Ino4. Inositol 149-157 Ino2p Saccharomyces cerevisiae S288C 125-129 20054697-3 2010 We used a set of 15 strains each defective for one of the non essential subunits of yeast mediator complex and identified med2, med3, med15, med18 and med19 as impaired for inositol biosynthesis. Inositol 173-181 Med2p Saccharomyces cerevisiae S288C 122-126 20054697-3 2010 We used a set of 15 strains each defective for one of the non essential subunits of yeast mediator complex and identified med2, med3, med15, med18 and med19 as impaired for inositol biosynthesis. Inositol 173-181 Pgd1p Saccharomyces cerevisiae S288C 128-132 20054697-3 2010 We used a set of 15 strains each defective for one of the non essential subunits of yeast mediator complex and identified med2, med3, med15, med18 and med19 as impaired for inositol biosynthesis. Inositol 173-181 Gal11p Saccharomyces cerevisiae S288C 134-139 20054697-3 2010 We used a set of 15 strains each defective for one of the non essential subunits of yeast mediator complex and identified med2, med3, med15, med18 and med19 as impaired for inositol biosynthesis. Inositol 173-181 Srb5p Saccharomyces cerevisiae S288C 141-146 20054697-3 2010 We used a set of 15 strains each defective for one of the non essential subunits of yeast mediator complex and identified med2, med3, med15, med18 and med19 as impaired for inositol biosynthesis. Inositol 173-181 Rox3p Saccharomyces cerevisiae S288C 151-156 20118926-3 2010 Unexpectedly, the most abundant transcript in axons was mRNA for myo-inositol monophosphatase-1 (Impa1), a key enzyme that regulates the inositol cycle and the main target of lithium in neurons. Inositol 69-77 inositol monophosphatase 1 Rattus norvegicus 97-102 20044451-9 2010 Metabolomic profiling of the ron1-1 mutant revealed changes in the levels of 38 metabolites, including myoinositol and indole-3-acetonitrile, a precursor of auxin. Inositol 103-114 SAL1 phosphatase-like protein Arabidopsis thaliana 29-35 20215587-6 2010 The mips1 mutants have lower myo-inositol, ascorbic acid, and phosphatidylinositol levels, while basal levels of inositol (1,4,5)P(3) are not altered in mips1 mutants. Inositol 29-41 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 4-9 20215587-9 2010 Thus, MIPS1 has a significant impact on myo-inositol levels that is critical for maintaining levels of ascorbic acid, phosphatidylinositol, and ceramides that regulate growth, development, and cell death. Inositol 40-52 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 6-11 20009031-3 2010 Fourteen Glut proteins are expressed in the human and they include transporters for substrates other than glucose, including fructose, myoinositol, and urate. Inositol 135-146 solute carrier family 2 member 1 Homo sapiens 9-13 20297738-5 2010 Both behavioral and localization defects in ttx-7 mutants were rescued by expression of IMPase at the adult stage and Inositol application, and were mimicked by Lithium application in wild type animals. Inositol 118-126 Inositol monophosphatase ttx-7 Caenorhabditis elegans 44-49 20103773-1 2010 Autophosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) is required for its activation, which elicits the cellular unfolded protein response (UPR) and is functionally connected with insulin biosynthesis in pancreatic beta cells. Inositol 23-31 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 57-66 20091537-0 2010 Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Inositol 67-83 insulin Homo sapiens 0-7 20609227-7 2010 In FM patients, decreased myoinositol/creatine (Ins/Cr) ratios were found in the left sensorimotor area (P = 0.05) and the left hippocampus (P = 0.002) and lower levels of choline (P = 0.019) and N-acetyl aspartate + N-acetyl aspartyl glutamate (NAA + NAG) (P = 0.034) in the left hippocampus. Inositol 26-37 NBAS subunit of NRZ tethering complex Homo sapiens 252-255 20460718-0 2010 D-pinitol and myo-inositol stimulate translocation of glucose transporter 4 in skeletal muscle of C57BL/6 mice. Inositol 14-26 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 54-75 20460718-2 2010 We have previously demonstrated that certain inositol derivatives stimulated glucose uptake accompanied by the translocation of glucose transporter 4 (GLUT4) to the plasma membrane in L6 myotubes. Inositol 45-53 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 128-149 20460718-2 2010 We have previously demonstrated that certain inositol derivatives stimulated glucose uptake accompanied by the translocation of glucose transporter 4 (GLUT4) to the plasma membrane in L6 myotubes. Inositol 45-53 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 151-156 20460718-3 2010 We investigated in this present study whether an oral intake of D-pinitol (PI) and myo-inositol (MI) would affect GLUT4 translocation in the skeletal muscle of mice. Inositol 83-95 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 114-119 20002879-5 2010 We also show that distinct mechanisms of UapA endocytosis necessitate ubiquitination of a single Lys residue (K572) by HulA(Rsp5). Inositol 110-114 NEDD4 like E3 ubiquitin protein ligase Homo sapiens 124-128 19843653-11 2009 In the mouse model of AAI, we found downregulation of inositol polyphosphate 4 phosphatase A (INPP4A), a critical member of the inositol signaling pathway. Inositol 54-62 inositol polyphosphate-4-phosphatase, type I Mus musculus 94-100 19841481-7 2009 Consistent with a synthetic impairment between challenged ER function and inositol deprivation, increased expression of NTE1 improved the growth of cells exposed to tunicamycin in the absence of inositol. Inositol 74-82 lysophospholipase Saccharomyces cerevisiae S288C 120-124 19841481-7 2009 Consistent with a synthetic impairment between challenged ER function and inositol deprivation, increased expression of NTE1 improved the growth of cells exposed to tunicamycin in the absence of inositol. Inositol 195-203 lysophospholipase Saccharomyces cerevisiae S288C 120-124 19880507-1 2009 The SH2 domain containing inositol 5-phosphatase SHIP2 contains several interacting domains that are important for scaffolding properties. Inositol 26-34 inositol polyphosphate phosphatase like 1 Homo sapiens 49-54 19800728-3 2009 Nevertheless its positive role in PCOS women is a consequence of a defect in the insulin signaling pathway (inositol-containing phosphoglycan mediators) that seems to be primarily implicated in the pathogenesis of insulin resistance. Inositol 108-116 insulin Homo sapiens 81-88 19800728-3 2009 Nevertheless its positive role in PCOS women is a consequence of a defect in the insulin signaling pathway (inositol-containing phosphoglycan mediators) that seems to be primarily implicated in the pathogenesis of insulin resistance. Inositol 108-116 insulin Homo sapiens 214-221 19752028-8 2009 We show here that in macrophage-like cells, Stx1 activated the proximal ER stress sensors RNA-dependent protein kinase-like ER kinase and inositol-requiring ER signal kinase 1alpha but did not activate activating transcription factor 6. Inositol 138-146 syntaxin 1A Homo sapiens 44-48 19839650-1 2009 SH2 domain-containing inositol 5-phosphatases 1 (SHIP1) and 2 (SHIP2) are structurally similar proteins that catalyze the degradation of lipid secondary messenger phosphatidylinositol 3,4,5-triphosphate to produce phosphatidylinositol 3,4-diphosphate. Inositol 22-30 inositol polyphosphate-5-phosphatase D Homo sapiens 49-54 19839650-1 2009 SH2 domain-containing inositol 5-phosphatases 1 (SHIP1) and 2 (SHIP2) are structurally similar proteins that catalyze the degradation of lipid secondary messenger phosphatidylinositol 3,4,5-triphosphate to produce phosphatidylinositol 3,4-diphosphate. Inositol 22-30 inositol polyphosphate phosphatase like 1 Homo sapiens 63-68 19586572-1 2009 d-chiro-inositol (DCI) and pinitol (1d-3-O-methyl-chiro-inositol) are distinctive inositols reported to possess insulin-mimetic properties. Inositol 0-16 enoyl-CoA delta isomerase 1 Rattus norvegicus 18-21 19586572-1 2009 d-chiro-inositol (DCI) and pinitol (1d-3-O-methyl-chiro-inositol) are distinctive inositols reported to possess insulin-mimetic properties. Inositol 82-91 enoyl-CoA delta isomerase 1 Rattus norvegicus 18-21 19812700-3 2009 A yeast two-hybrid screen using ATXR5 as bait captured AtIPS1, an enzyme which catalyses the committed step of myo-inositol (MI) biosynthesis. Inositol 111-123 TRITHORAX-RELATED PROTEIN 5 Arabidopsis thaliana 32-37 19812700-3 2009 A yeast two-hybrid screen using ATXR5 as bait captured AtIPS1, an enzyme which catalyses the committed step of myo-inositol (MI) biosynthesis. Inositol 111-123 induced by phosphate starvation1 Arabidopsis thaliana 55-61 19821299-0 2009 Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Inositol 67-83 insulin Homo sapiens 0-7 19754464-6 2009 In homozygous Smit1-knockout mice, free inositol levels were decreased in the frontal cortex and hippocampus. Inositol 40-48 solute carrier family 5 (inositol transporters), member 3 Mus musculus 14-19 19754467-3 2009 Inositol is taken up by neurons from the extracellular fluid, presumably via membrane transporters; it can also be synthesized by the enzyme MIP-synthase (myo-inositol-1-phosphate synthase) and, in addition, it is generated by inositol phospholipid hydrolysis. Inositol 0-8 inositol-3-phosphate synthase 1 Homo sapiens 141-153 19754467-4 2009 The neuronal-specific HMIT (H(+)-myo-inositol transporter) represents a potential regulator of inositol signalling in neurons that warrants further investigation. Inositol 37-45 solute carrier family 2 member 13 Homo sapiens 22-26 19762259-0 2009 InCa-SiteFinder: a method for structure-based prediction of inositol and carbohydrate binding sites on proteins. Inositol 60-68 caspase recruitment domain family member 17 Homo sapiens 0-4 19509075-6 2009 RESULTS: Myo-inositol (mIns) levels correlated with BCAA/AAA ratios (r = 0.86; P = .002 for GM and r = 0.77; P = .01 for WM). Inositol 9-21 AT-rich interaction domain 4B Homo sapiens 52-56 19593677-15 2009 IMPA1 is regulated by another calcium-binding protein calbindin-D28k (CaB), since we reported earlier that the CaB levels are reduced in SCA1 PCs, the activation of IMPA1 by S100B may modulate CaB-dependent inositol signaling. Inositol 207-215 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 0-5 19593677-15 2009 IMPA1 is regulated by another calcium-binding protein calbindin-D28k (CaB), since we reported earlier that the CaB levels are reduced in SCA1 PCs, the activation of IMPA1 by S100B may modulate CaB-dependent inositol signaling. Inositol 207-215 calbindin 1 Mus musculus 54-68 19593677-15 2009 IMPA1 is regulated by another calcium-binding protein calbindin-D28k (CaB), since we reported earlier that the CaB levels are reduced in SCA1 PCs, the activation of IMPA1 by S100B may modulate CaB-dependent inositol signaling. Inositol 207-215 calbindin 1 Mus musculus 70-73 19593677-15 2009 IMPA1 is regulated by another calcium-binding protein calbindin-D28k (CaB), since we reported earlier that the CaB levels are reduced in SCA1 PCs, the activation of IMPA1 by S100B may modulate CaB-dependent inositol signaling. Inositol 207-215 ataxin 1 Mus musculus 137-141 19593677-15 2009 IMPA1 is regulated by another calcium-binding protein calbindin-D28k (CaB), since we reported earlier that the CaB levels are reduced in SCA1 PCs, the activation of IMPA1 by S100B may modulate CaB-dependent inositol signaling. Inositol 207-215 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 165-170 19593677-15 2009 IMPA1 is regulated by another calcium-binding protein calbindin-D28k (CaB), since we reported earlier that the CaB levels are reduced in SCA1 PCs, the activation of IMPA1 by S100B may modulate CaB-dependent inositol signaling. Inositol 207-215 S100 protein, beta polypeptide, neural Mus musculus 174-179 19494026-5 2009 The plasma inositol concentration was 175.74 (59.71-300.60) micromol/L and Ra was 1.06 (0.33-1.75) micromol x kg(-1).min(-1) (1521 micromol x kg(-1) x d(-1)). Inositol 11-19 CD59 molecule (CD59 blood group) Homo sapiens 117-123 19668216-0 2009 Mutations in INPP5E, encoding inositol polyphosphate-5-phosphatase E, link phosphatidyl inositol signaling to the ciliopathies. Inositol 30-38 inositol polyphosphate-5-phosphatase E Homo sapiens 13-19 19551544-7 2009 RESULTS: After 3 months of MYO administration, plasma LH, testosterone, free testosterone, insulin and HOMA index resulted significantly reduced; no significant changes were observed in plasma FSH and androstenedione levels. Inositol 27-30 insulin Homo sapiens 91-98 19494109-2 2009 The SH2 domain-containing inositol 5" phosphatase, SHIP1, regulates hematopoietic cell function by opposing the action of phos pha tidyl ino si tol 3-kinase and reducing the levels of PtdIns 3,4,5-P(3). Inositol 26-34 inositol polyphosphate-5-phosphatase D Homo sapiens 51-56 19215021-9 2009 CONCLUSIONS: These data suggest that the child"s PDGFRA promoter haplotype is differentially sensitive for periconceptional exposure to glucose, myo-inositol, and zinc in the risk of spina bifida. Inositol 145-157 platelet derived growth factor receptor alpha Homo sapiens 49-55 19237191-3 2009 UPR inhibition using inositol-requiring enzyme 1alpha (IRE1alpha) or activating transcription factor 6 (ATF6) dominant-negative mutants diminished the ability of Bcr-Abl to protect the cells from etoposide- and imatinib-induced apoptosis. Inositol 21-29 ABL proto-oncogene 1, non-receptor tyrosine kinase Homo sapiens 162-169 19306919-1 2009 The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal nucleoside diphosphate in the sucrose cleavage reaction and in trehalose biosynthesis. Inositol 55-63 myo-inositol-3-phosphate synthase Glycine max 84-88 19306919-1 2009 The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal nucleoside diphosphate in the sucrose cleavage reaction and in trehalose biosynthesis. Inositol 55-63 sucrose synthase Glycine max 154-170 19306919-1 2009 The aim of this review is to highlight the role of myo-inositol phosphate synthase (MIPS), which catalyses the first step in inositol biosynthesis and of sucrose synthase (Sus), an enzyme involved in UDP-glucose formation, the principal nucleoside diphosphate in the sucrose cleavage reaction and in trehalose biosynthesis. Inositol 55-63 sucrose synthase Glycine max 172-175 19053028-1 2009 Myo-inositol oxygenase (MIOX) catalyzes the oxidative cleavage of myo-inositol (MI) to give D-glucuronic acid, a committed step in MI catabolism. Inositol 66-78 myo-inositol oxygenase Rattus norvegicus 0-22 19053028-1 2009 Myo-inositol oxygenase (MIOX) catalyzes the oxidative cleavage of myo-inositol (MI) to give D-glucuronic acid, a committed step in MI catabolism. Inositol 66-78 myo-inositol oxygenase Rattus norvegicus 24-28 19456874-11 2009 Consistent with this derepression, reduced PIS1 expression also yielded an overproduction of inositol (Opi(-)) phenotype. Inositol 93-101 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 43-47 19332564-4 2009 The ess1(A144T) and ess1(H164R) mutants, initially described by Hanes and coworkers (Yeast 5:55-72, 1989), accumulate the pSer5 phosphorylated form of Pol II; confer phosphate, galactose, and inositol auxotrophies; and fail to activate PHO5, GAL10, and INO1 reporter genes. Inositol 192-200 peptidylprolyl isomerase ESS1 Saccharomyces cerevisiae S288C 4-8 19332564-4 2009 The ess1(A144T) and ess1(H164R) mutants, initially described by Hanes and coworkers (Yeast 5:55-72, 1989), accumulate the pSer5 phosphorylated form of Pol II; confer phosphate, galactose, and inositol auxotrophies; and fail to activate PHO5, GAL10, and INO1 reporter genes. Inositol 192-200 peptidylprolyl isomerase ESS1 Saccharomyces cerevisiae S288C 20-24 19339506-0 2009 VTC4 is a bifunctional enzyme that affects myoinositol and ascorbate biosynthesis in plants. Inositol 43-54 Inositol monophosphatase family protein Arabidopsis thaliana 0-4 19339506-7 2009 Analysis of metabolite levels in vtc4 mutants showed that less myoinositol and ascorbate accumulate in these mutants. Inositol 63-74 Inositol monophosphatase family protein Arabidopsis thaliana 33-37 19339506-8 2009 Therefore, VTC4 is a bifunctional enzyme that impacts both myoinositol and ascorbate synthesis pathways. Inositol 59-70 Inositol monophosphatase family protein Arabidopsis thaliana 11-15 19234089-9 2009 The S1P(1)-specific agonism with oral SEW2871 during the first 2-wk after MI reduced apoptosis in the RM and resulted in improved myocardial function, as reflected in the echocardiographic measurement of fractional shortening. Inositol 74-76 sphingosine-1-phosphate receptor 1 Mus musculus 4-7 19336734-0 2009 The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. Inositol 26-37 AKT serine/threonine kinase 1 Homo sapiens 47-50 19336734-0 2009 The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers. Inositol 26-37 mitogen-activated protein kinase 1 Homo sapiens 55-92 19336734-4 2009 Before myoinositol treatment, strongly positive staining for activation of Akt was detected in 27% of hyperplastic/metaplastic lesions and 58% of dysplastic lesions (P = 0.05, chi(2) test). Inositol 7-18 AKT serine/threonine kinase 1 Homo sapiens 75-78 19336734-6 2009 Following myoinositol treatment, significant decreases in Akt and ERK phosphorylation were observed in dysplastic (P < 0.01 and 0.05, respectively) but not hyperplastic/metaplastic lesions (P > 0.05). Inositol 10-21 AKT serine/threonine kinase 1 Homo sapiens 58-61 19336734-6 2009 Following myoinositol treatment, significant decreases in Akt and ERK phosphorylation were observed in dysplastic (P < 0.01 and 0.05, respectively) but not hyperplastic/metaplastic lesions (P > 0.05). Inositol 10-21 mitogen-activated protein kinase 1 Homo sapiens 66-69 19336734-7 2009 In vitro, myoinositol decreased endogenous and tobacco carcinogen-induced activation of Akt and ERK in immortalized human bronchial epithelial cells, which decreased cell proliferation and induced a G(1)-S cell cycle arrest. Inositol 10-21 AKT serine/threonine kinase 1 Homo sapiens 88-91 19336734-7 2009 In vitro, myoinositol decreased endogenous and tobacco carcinogen-induced activation of Akt and ERK in immortalized human bronchial epithelial cells, which decreased cell proliferation and induced a G(1)-S cell cycle arrest. Inositol 10-21 mitogen-activated protein kinase 1 Homo sapiens 96-99 19336734-8 2009 These results show that the phenotypic progression of premalignant bronchial lesions from smokers correlates with increased activation of Akt and ERK and that these kinases are targets of myoinositol. Inositol 188-199 AKT serine/threonine kinase 1 Homo sapiens 138-141 19336734-9 2009 Moreover, they suggest that myoinositol might cause regression of bronchial dysplastic lesions through inhibition of active Akt and ERK. Inositol 28-39 AKT serine/threonine kinase 1 Homo sapiens 124-127 19336734-9 2009 Moreover, they suggest that myoinositol might cause regression of bronchial dysplastic lesions through inhibition of active Akt and ERK. Inositol 28-39 mitogen-activated protein kinase 1 Homo sapiens 132-135 19193809-8 2009 pUL38 also allowed the virus to suppress persistent phosphorylation of c-Jun N-terminal kinase (JNK), which was induced by the inositol-requiring enzyme 1 pathway. Inositol 127-135 mitogen-activated protein kinase 8 Homo sapiens 96-99 19139096-5 2009 In contrast, sac1Delta dramatically reduced inositol phosphosphingolipids, which result from the addition of a PtdIns-derived phosphoinositol head group to ceramides through Aur1p. Inositol 44-52 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 13-17 19139096-5 2009 In contrast, sac1Delta dramatically reduced inositol phosphosphingolipids, which result from the addition of a PtdIns-derived phosphoinositol head group to ceramides through Aur1p. Inositol 44-52 inositol phosphorylceramide synthase Saccharomyces cerevisiae S288C 174-179 19499845-1 2009 To investigate the effects of treatment with Myo-inositol (an insulin sensitizing drug), on circulating insulin, glucose tolerance, ovulation and serum androgens concentrations in women with the Polycystic Ovary Syndrome (PCOS). Inositol 45-57 insulin Homo sapiens 104-111 19499845-10 2009 Treatment of PCOS patients with Myo-inositol provided a decreasing of circulating insulin and serum total testosterone as well as an improvement in metabolic factors. Inositol 32-44 insulin Homo sapiens 82-89 18791164-4 2009 This cross-regulation requires BCR and FcgammaRIIB coligation, and optimal action relies on the Src-homology-2 (SH2)-containing inositol 5 phosphase-1 (SHIP1). Inositol 128-136 inositol polyphosphate-5-phosphatase D Homo sapiens 152-157 19173070-1 2009 The enzyme myo-inositol oxygenase (MIOX) catalyzes conversion of myo-inositol (cyclohexan-1,2,3,5/4,6-hexa-ol or MI) to d-glucuronate (DG), initiating the only known pathway in humans for catabolism of the carbon skeleton of cell-signaling inositol (poly)phosphates and phosphoinositides. Inositol 11-23 myo-inositol oxygenase Homo sapiens 35-39 19060162-2 2009 Coexpression of the genes encoding myo-inositol-1-phosphate synthase (Ino1) from Saccharomyces cerevisiae and myo-inositol oxygenase (MIOX) from mice led to production of glucuronic acid through the intermediate myo-inositol. Inositol 35-47 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 70-74 19183264-3 2009 In this study, a yeast inositol-auxotrophy assay has confirmed that P56S-VAPB is functionally a null mutant in vivo. Inositol 23-31 vesicle-associated membrane protein, associated protein B and C Mus musculus 73-77 19032932-0 2009 Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. Inositol 57-66 solute carrier family 5 member 11 Homo sapiens 6-37 19032932-0 2009 Human sodium/inositol cotransporter 2 (SMIT2) transports inositols but not glucose in L6 cells. Inositol 57-66 solute carrier family 5 member 11 Homo sapiens 39-44 19032932-1 2009 To characterize the function of the sodium/inositol symporter SMIT2 in skeletal muscle, human SMIT2 cDNA was transfected into L6 myoblasts using pcDNA3.1 expression vector. Inositol 43-51 solute carrier family 5 member 11 Homo sapiens 62-67 19032932-5 2009 The K(m) of DCI and myo-inositol for DCI uptake was 111.0 and 158.0 microM, respectively, whereas glucose competed for DCI uptake with a K(i) of 6.1 mM. Inositol 20-32 enoyl-CoA delta isomerase 1 Homo sapiens 37-40 19032932-5 2009 The K(m) of DCI and myo-inositol for DCI uptake was 111.0 and 158.0 microM, respectively, whereas glucose competed for DCI uptake with a K(i) of 6.1 mM. Inositol 20-32 enoyl-CoA delta isomerase 1 Homo sapiens 37-40 19032932-8 2009 Therefore, expression and/or function of SMIT2, a high affinity transporter specific for DCI and myo-inositol, may be reduced in diabetes mellitus, insulin resistance and polycystic ovary syndrome causing the abnormal DCI metabolism observed in these conditions. Inositol 97-109 solute carrier family 5 member 11 Homo sapiens 41-46 19689267-1 2009 Phosphatidylinositol 3-kinases (PI3Ks) are a class of lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which in turn activates Akt and the downstream effectors like mTOR, and therefore play important roles in cell growth, survival, etc. Inositol 12-20 AKT serine/threonine kinase 1 Homo sapiens 250-253 19689267-1 2009 Phosphatidylinositol 3-kinases (PI3Ks) are a class of lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which in turn activates Akt and the downstream effectors like mTOR, and therefore play important roles in cell growth, survival, etc. Inositol 12-20 mechanistic target of rapamycin kinase Homo sapiens 288-292 20093832-1 2009 BACKGROUND/AIMS: To explore the potential value of myo-inositol (mIns), which is regarded as a biomarker for early diagnosis of Alzheimer"s disease, in APP/PS1 transgenic (tg) mice detected by (1)H-MRS. METHODS: (1)H-MRS was performed in 30 APP/PS1 tg mice and 20 wild-type (wt) littermates at 3, 5 and 8 months of age. Inositol 65-69 presenilin 1 Mus musculus 156-159 19492925-2 2009 Inositol phosphoglycan P-type (P-IPG), a second messenger of insulin, was reported to negatively correlate with the degree of insulin resistance in non-pregnant diabetic subjects. Inositol 0-8 insulin Homo sapiens 61-68 19492925-2 2009 Inositol phosphoglycan P-type (P-IPG), a second messenger of insulin, was reported to negatively correlate with the degree of insulin resistance in non-pregnant diabetic subjects. Inositol 0-8 insulin Homo sapiens 126-133 19059532-0 2009 Hyperinsulinemia is closely related to low urinary clearance of D-chiro-inositol in men with a wide range of insulin sensitivity. Inositol 64-80 insulin Homo sapiens 5-12 19059532-1 2009 We have previously shown that women with polycystic ovary syndrome (PCOS) have increased urinary clearance of D-chiro-inositol (uCl(DCI)), which was positively associated with hyperinsulinemia. Inositol 110-126 enoyl-CoA delta isomerase 1 Homo sapiens 132-135 19059532-8 2009 In this group, plasma DCI was increased by 3-fold (P = .02), with a 3-fold decrease in the uCl(DCI) to urinary clearance of myo-inositol ratio, which was almost significant (P = .07). Inositol 124-136 enoyl-CoA delta isomerase 1 Homo sapiens 95-98 18979283-7 2009 We show here that hexanoic acid, heptanoic acid, octanoic acid, nonanoic acid, decanoic acid, ethylhexanoate, and methyloctanoate decrease intracellular inositol levels and increase the expression of INO1, the gene encoding myo-inositol-3-phosphate synthase (MIPS). Inositol 153-161 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 200-204 18979283-9 2009 A correlation was shown between cell growth inhibition and the increase in INO1 expression by the carboxylic acids, factors that were reversed in the presence of inositol. Inositol 162-170 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 75-79 18842580-3 2008 Mutants defective in this pathway exhibit a choline-sensitive inositol auxotrophy, yet fully derepress INO1 and other Opi1p-regulated genes when grown in the absence of inositol. Inositol 169-177 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 118-123 18957879-3 2008 RECENT FINDINGS: Inositol requiring enzyme1beta has been identified as a novel intestine-specific regulator of MTP. Inositol 17-25 microsomal triglyceride transfer protein Homo sapiens 111-114 18957879-7 2008 On the basis of these and other findings, we propose that upregulation of inositol requiring enzyme 1beta, a combined reduction of cellular free cholesterol or triglyceride or both and MTP activity, specific inhibition of phospholipid or triglyceride transfer activities, and targeting of apolipoprotein B-MTP protein-protein interactions might be pursued to avoid some of the side effects associated with the inhibition of triglyceride transfer activity of MTP. Inositol 74-82 microsomal triglyceride transfer protein Homo sapiens 185-188 18957879-7 2008 On the basis of these and other findings, we propose that upregulation of inositol requiring enzyme 1beta, a combined reduction of cellular free cholesterol or triglyceride or both and MTP activity, specific inhibition of phospholipid or triglyceride transfer activities, and targeting of apolipoprotein B-MTP protein-protein interactions might be pursued to avoid some of the side effects associated with the inhibition of triglyceride transfer activity of MTP. Inositol 74-82 apolipoprotein B Homo sapiens 289-305 18957879-7 2008 On the basis of these and other findings, we propose that upregulation of inositol requiring enzyme 1beta, a combined reduction of cellular free cholesterol or triglyceride or both and MTP activity, specific inhibition of phospholipid or triglyceride transfer activities, and targeting of apolipoprotein B-MTP protein-protein interactions might be pursued to avoid some of the side effects associated with the inhibition of triglyceride transfer activity of MTP. Inositol 74-82 microsomal triglyceride transfer protein Homo sapiens 306-309 18957879-7 2008 On the basis of these and other findings, we propose that upregulation of inositol requiring enzyme 1beta, a combined reduction of cellular free cholesterol or triglyceride or both and MTP activity, specific inhibition of phospholipid or triglyceride transfer activities, and targeting of apolipoprotein B-MTP protein-protein interactions might be pursued to avoid some of the side effects associated with the inhibition of triglyceride transfer activity of MTP. Inositol 74-82 microsomal triglyceride transfer protein Homo sapiens 306-309 19019152-0 2008 Transcription regulation of the Saccharomyces cerevisiae PIS1 gene by inositol and the pleiotropic regulator, Ume6p. Inositol 70-78 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 57-61 19019152-1 2008 In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed in their absence. Inositol 165-173 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 96-100 19019152-1 2008 In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed in their absence. Inositol 165-173 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 102-106 19019152-1 2008 In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed in their absence. Inositol 165-173 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 108-112 19019152-1 2008 In Saccharomyces cerevisiae, transcription of most of the phospholipid biosynthetic genes (e.g. INO1, CHO1, CHO2 and OPI3) is repressed by growth in the presence of inositol and choline and derepressed in their absence. Inositol 165-173 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 117-121 19019152-4 2008 Previous reports show that PIS1 expression is uncoupled from inositol/choline regulation, but is regulated by carbon source, hypoxia and zinc. Inositol 61-69 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 27-31 19019152-5 2008 However, in this study we found that the expression of PIS1 is induced twofold by inositol. Inositol 82-90 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 55-59 19019152-9 2008 Inositol induction did require another general regulator of phospholipid biosynthesis, Ume6p. Inositol 0-8 DNA-binding transcriptional regulator UME6 Saccharomyces cerevisiae S288C 87-92 18768324-7 2008 These results indicate that USP is the only pyrophosphorylase that utilizes UDP-GlcA as a substrate and suggest that it serves as the terminal enzyme of the myo-inositol oxidation pathway. Inositol 157-169 UDP-sugar pyrophosphorylase Arabidopsis thaliana 28-31 18842113-2 2008 As a result of formation of PtdIns with an added phosphate at the 3 position of the inositol ring, activation of the protein kinases PDK1 (phosphoinositide-dependent kinase 1) and PKB (protein kinase B)/Akt occurs. Inositol 84-92 pyruvate dehydrogenase kinase 1 Homo sapiens 133-137 18842113-2 2008 As a result of formation of PtdIns with an added phosphate at the 3 position of the inositol ring, activation of the protein kinases PDK1 (phosphoinositide-dependent kinase 1) and PKB (protein kinase B)/Akt occurs. Inositol 84-92 pyruvate dehydrogenase kinase 1 Homo sapiens 139-174 18842113-2 2008 As a result of formation of PtdIns with an added phosphate at the 3 position of the inositol ring, activation of the protein kinases PDK1 (phosphoinositide-dependent kinase 1) and PKB (protein kinase B)/Akt occurs. Inositol 84-92 protein tyrosine kinase 2 beta Homo sapiens 180-183 18842113-2 2008 As a result of formation of PtdIns with an added phosphate at the 3 position of the inositol ring, activation of the protein kinases PDK1 (phosphoinositide-dependent kinase 1) and PKB (protein kinase B)/Akt occurs. Inositol 84-92 protein tyrosine kinase 2 beta Homo sapiens 185-201 18842113-2 2008 As a result of formation of PtdIns with an added phosphate at the 3 position of the inositol ring, activation of the protein kinases PDK1 (phosphoinositide-dependent kinase 1) and PKB (protein kinase B)/Akt occurs. Inositol 84-92 AKT serine/threonine kinase 1 Homo sapiens 203-206 18940392-4 2008 Subjects with higher urinary D-chiro-inositol excretion had higher insulin (rho = 0.51, P < or = .05) and C-peptide (rho = 0.56, P < or = .05) area under the curves, and lower insulin sensitivity index (rho = -0.60, P < or = .05) during the intravenous glucose tolerance test. Inositol 29-45 insulin Homo sapiens 67-74 18940392-4 2008 Subjects with higher urinary D-chiro-inositol excretion had higher insulin (rho = 0.51, P < or = .05) and C-peptide (rho = 0.56, P < or = .05) area under the curves, and lower insulin sensitivity index (rho = -0.60, P < or = .05) during the intravenous glucose tolerance test. Inositol 29-45 insulin Homo sapiens 182-189 18940392-5 2008 The urinary myo- to D-chiro-inositol ratio was also inversely related to insulin area under the curve (rho = -0.59, P < or = .05). Inositol 20-36 insulin Homo sapiens 73-80 18940392-6 2008 Urinary D-chiro-inositol (rho = -0.60, P < or = .05) and myo-inositol (rho = -0.60, P < or = .05) were inversely related to tyrosine phosphorylation of the insulin receptor (phosphotyrosine 1162/1163), but not total content of the insulin receptor during the OGTT. Inositol 8-24 insulin receptor Homo sapiens 162-178 18940392-6 2008 Urinary D-chiro-inositol (rho = -0.60, P < or = .05) and myo-inositol (rho = -0.60, P < or = .05) were inversely related to tyrosine phosphorylation of the insulin receptor (phosphotyrosine 1162/1163), but not total content of the insulin receptor during the OGTT. Inositol 8-24 insulin receptor Homo sapiens 237-253 18940392-6 2008 Urinary D-chiro-inositol (rho = -0.60, P < or = .05) and myo-inositol (rho = -0.60, P < or = .05) were inversely related to tyrosine phosphorylation of the insulin receptor (phosphotyrosine 1162/1163), but not total content of the insulin receptor during the OGTT. Inositol 60-72 insulin receptor Homo sapiens 162-178 18940392-6 2008 Urinary D-chiro-inositol (rho = -0.60, P < or = .05) and myo-inositol (rho = -0.60, P < or = .05) were inversely related to tyrosine phosphorylation of the insulin receptor (phosphotyrosine 1162/1163), but not total content of the insulin receptor during the OGTT. Inositol 60-72 insulin receptor Homo sapiens 237-253 18718510-2 2008 POP also has an intercellular function mediated through the inositol pathway, and has been involved in cell death. Inositol 60-68 prolyl endopeptidase Homo sapiens 0-3 18803944-0 2008 Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Inositol 30-46 insulin Homo sapiens 0-7 18803944-0 2008 Insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator correlates with insulin sensitivity in women with polycystic ovary syndrome. Inositol 30-46 insulin Homo sapiens 105-112 18803944-2 2008 Deficient release of a putative D-chiro-inositol-containing (DCI) IPG mediator may contribute to insulin resistance in women with polycystic ovary syndrome (PCOS). Inositol 32-48 insulin Homo sapiens 97-104 18506424-2 2008 In contrast, myo-inositol uptake is inhibited at low concentrations, reflecting that it occurs both by the high-affinity Na(+)-dependent myo-inositol transporter (SMIT) and the lower-affinity H(+)-dependent inositol transporter (HMIT). Inositol 13-25 solute carrier family 5 member 3 Homo sapiens 163-167 18506424-2 2008 In contrast, myo-inositol uptake is inhibited at low concentrations, reflecting that it occurs both by the high-affinity Na(+)-dependent myo-inositol transporter (SMIT) and the lower-affinity H(+)-dependent inositol transporter (HMIT). Inositol 13-25 solute carrier family 2 member 13 Homo sapiens 229-233 18675571-0 2008 Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. Inositol 43-55 solute carrier family 5 (inositol transporters), member 3 Mus musculus 73-78 18675571-0 2008 Characterization of the null murine sodium/myo-inositol cotransporter 1 (Smit1 or Slc5a3) phenotype: myo-inositol rescue is independent of expression of its cognate mitochondrial ribosomal protein subunit 6 (Mrps6) gene and of phosphatidylinositol levels in neonatal brain. Inositol 43-55 solute carrier family 5 (inositol transporters), member 3 Mus musculus 82-88 18536757-10 2008 AT1 receptors were upregulated 8 weeks after MI, this was further increased by hypercholesterolaemia and restored to baseline levels by atorvastatin. Inositol 45-47 angiotensin II receptor, type 1a Rattus norvegicus 0-3 18385167-7 2008 Notably, the variant CFTR-mediated conductance was detected in IB3-1 cells treated with myoinositol and was enhanced by ibuprofen at endogenous levels of cAMP. Inositol 88-99 CF transmembrane conductance regulator Homo sapiens 21-25 18507737-5 2008 Following REOX, a biphasic change in Ca(2+)(ER) occurred with an initial release of Ca(2+)(ER) which was sensitive to inositol 1,4,5-trisphosphate receptor (IP(3)R) inhibition and a subsequent refilling of Ca(2+)(ER) stores. Inositol 118-126 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 157-163 18609357-1 2008 OBJECTIVE: Abnormal metabolism of inositol phosphoglycan P-type (P-IPG) has been described in insulin-resistant states. Inositol 34-42 insulin Homo sapiens 94-101 18487437-3 2008 It has been reported that DGKepsilon acts specifically on DAG produced by inositol cycling. Inositol 74-82 diacylglycerol kinase, epsilon Mus musculus 26-36 18542964-1 2008 Structural genes of phospholipid biosynthesis in the yeast S. cerevisiae are activated by the heterodimeric transcription factor Ino2 + Ino4, binding to ICRE (inositol/choline-responsive element) promoter motifs. Inositol 159-167 Ino2p Saccharomyces cerevisiae S288C 129-133 18542964-1 2008 Structural genes of phospholipid biosynthesis in the yeast S. cerevisiae are activated by the heterodimeric transcription factor Ino2 + Ino4, binding to ICRE (inositol/choline-responsive element) promoter motifs. Inositol 159-167 Ino4p Saccharomyces cerevisiae S288C 136-140 18542964-8 2008 We could show that Ino2-dependent activation of a lexA-Ino4 fusion is affected by inositol and choline. Inositol 82-90 Ino2p Saccharomyces cerevisiae S288C 19-23 18542964-8 2008 We could show that Ino2-dependent activation of a lexA-Ino4 fusion is affected by inositol and choline. Inositol 82-90 Ino4p Saccharomyces cerevisiae S288C 55-59 18426884-1 2008 The SH2 domain-containing inositol 5"-phosphatase, SHIP, negatively regulates various hematopoietic cell functions and is critical for maintaining immune homeostasis. Inositol 26-34 inositol polyphosphate-5-phosphatase D Mus musculus 51-55 18562499-6 2008 The PIP(2)-channel interaction requires negative charge and the inositol moiety in the phospholipid headgroup, and the sequence RKK in the S6-S7 cytosolic linker of the BK channel-forming (cbv1) subunit. Inositol 64-72 prolactin induced protein Homo sapiens 4-7 18035849-6 2008 The association between myo-inositol (m-Ins) and astroglial glial fibrillary acidic protein (GFAP) expression revealed significantly increased m-Ins concentrations associated with diffuse astrogliosis (m-Ins = 6.4 +/- 1.1 institutional units) compared with gliosis restricted to isolated sectors of the hippocampus (i.e. hilus) (m-Ins = 5.2 +/- 1.2 institutional units) (P = 0.039). Inositol 24-36 glial fibrillary acidic protein Homo sapiens 60-91 18035849-6 2008 The association between myo-inositol (m-Ins) and astroglial glial fibrillary acidic protein (GFAP) expression revealed significantly increased m-Ins concentrations associated with diffuse astrogliosis (m-Ins = 6.4 +/- 1.1 institutional units) compared with gliosis restricted to isolated sectors of the hippocampus (i.e. hilus) (m-Ins = 5.2 +/- 1.2 institutional units) (P = 0.039). Inositol 24-36 glial fibrillary acidic protein Homo sapiens 93-97 18392779-9 2008 By labeling the endogenous myo-inositol pool in 5ptase11 mutants, we correlated these hypocotyl growth changes with a small increase in the 5PTase11 substrate, phosphatidylinositol (4,5) bisphosphate, and decreases in the potential products of 5PTase11, phosphatidylinositol (3) phosphate and phosphatidylinositol (4) phosphate. Inositol 27-39 inositol polyphosphate 5-phosphatase 11 Arabidopsis thaliana 48-56 18392779-9 2008 By labeling the endogenous myo-inositol pool in 5ptase11 mutants, we correlated these hypocotyl growth changes with a small increase in the 5PTase11 substrate, phosphatidylinositol (4,5) bisphosphate, and decreases in the potential products of 5PTase11, phosphatidylinositol (3) phosphate and phosphatidylinositol (4) phosphate. Inositol 27-39 inositol polyphosphate 5-phosphatase 11 Arabidopsis thaliana 140-148 18392779-9 2008 By labeling the endogenous myo-inositol pool in 5ptase11 mutants, we correlated these hypocotyl growth changes with a small increase in the 5PTase11 substrate, phosphatidylinositol (4,5) bisphosphate, and decreases in the potential products of 5PTase11, phosphatidylinositol (3) phosphate and phosphatidylinositol (4) phosphate. Inositol 27-39 inositol polyphosphate 5-phosphatase 11 Arabidopsis thaliana 244-252 18434318-2 2008 Deletion of PGC1 causes an accumulation of the anionic phospholipid, phosphatidylglycerol (PG), especially under conditions of inositol limitation. Inositol 127-135 phosphatidylglycerol phospholipase Saccharomyces cerevisiae S288C 12-16 18375940-7 2008 Increased clearance of inositols might reduce tissue availability of DCI and decrease the release of DCI-IPG mediator, which could contribute to insulin resistance and compensatory hyperinsulinemia in Greek women, as previously described in American women. Inositol 23-32 insulin Homo sapiens 145-152 18635905-5 2008 Among the hyperlipidemic subjects treated with myo-inositol, compared to subjects without MetS, subjects with MetS had a significant increase in plasmalogens and a tendency towards reduced sdLDL, high sensitivity C-reactive protein (hsCRP), and blood glucose levels. Inositol 47-59 C-reactive protein Homo sapiens 213-231 18364358-2 2008 The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to D-glucuronate. Inositol 38-46 myo-inositol oxygenase Homo sapiens 74-96 18364358-2 2008 The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to D-glucuronate. Inositol 38-46 myo-inositol oxygenase Homo sapiens 98-102 18364358-2 2008 The first committed step in mammalian inositol catabolism is performed by myo-inositol oxygenase (MIOX), which catalyzes a unique four-electron dioxygen-dependent ring cleavage of myo-inositol to D-glucuronate. Inositol 74-86 myo-inositol oxygenase Homo sapiens 98-102 18460335-2 2008 We explored the role of an ER stress protein, inositol-requiring enzyme 1beta (IRE1beta), in regulating this process. Inositol 46-54 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 79-87 18319316-5 2008 RESULTS: Compared with controls, young children with MCT8 show choline and myoinositol level increases and N-acetyl aspartate decreases in supraventricular gray and white matter, phenomena associated with the degree of dysmyelinization according to MRI. Inositol 75-86 solute carrier family 16 member 2 Homo sapiens 53-57 18431251-3 2008 Galectin 1 signals through the endoplasmic reticulum transmembrane kinase/ribonuclease inositol-requiring 1alpha, which regulates the expression of oxygen-regulated protein 150. Inositol 87-95 galectin 1 Homo sapiens 0-10 18441213-0 2008 Functional and physiological characterization of Arabidopsis INOSITOL TRANSPORTER1, a novel tonoplast-localized transporter for myo-inositol. Inositol 128-140 inositol transporter 1 Arabidopsis thaliana 61-82 18441213-2 2008 INT2 and INT4 were shown to encode plasma membrane-localized transporters for different inositol epimers, and INT3 was characterized as a pseudogene. Inositol 88-96 inositol transporter 2 Arabidopsis thaliana 0-4 18441213-2 2008 INT2 and INT4 were shown to encode plasma membrane-localized transporters for different inositol epimers, and INT3 was characterized as a pseudogene. Inositol 88-96 inositol transporter 4 Arabidopsis thaliana 9-13 18441213-4 2008 INT1 is a ubiquitously expressed gene, and Arabidopsis lines with T-DNA insertions in INT1 showed increased intracellular myo-inositol concentrations and reduced root growth. Inositol 122-134 inositol transporter 1 Arabidopsis thaliana 0-4 18441213-4 2008 INT1 is a ubiquitously expressed gene, and Arabidopsis lines with T-DNA insertions in INT1 showed increased intracellular myo-inositol concentrations and reduced root growth. Inositol 122-134 inositol transporter 1 Arabidopsis thaliana 86-90 18441213-7 2008 In summary, the presented molecular, physiological, and functional studies demonstrate that INT1 is a tonoplast-localized H(+)/inositol symporter that mediates the efflux of inositol that is generated during the degradation of inositol-containing compounds in the vacuolar lumen. Inositol 127-135 inositol transporter 1 Arabidopsis thaliana 92-96 18441213-7 2008 In summary, the presented molecular, physiological, and functional studies demonstrate that INT1 is a tonoplast-localized H(+)/inositol symporter that mediates the efflux of inositol that is generated during the degradation of inositol-containing compounds in the vacuolar lumen. Inositol 174-182 inositol transporter 1 Arabidopsis thaliana 92-96 18441213-7 2008 In summary, the presented molecular, physiological, and functional studies demonstrate that INT1 is a tonoplast-localized H(+)/inositol symporter that mediates the efflux of inositol that is generated during the degradation of inositol-containing compounds in the vacuolar lumen. Inositol 174-182 inositol transporter 1 Arabidopsis thaliana 92-96 18289524-10 2008 These results indicate that in aortic smooth muscle cells, TRPC1 is not only involved in Ca2+ entry activated by store depletion but also in receptor-operated Ca2+ entry, which requires inositol (1,4,5) triphosphate receptor activation. Inositol 186-194 transient receptor potential cation channel subfamily C member 1 Homo sapiens 59-64 18202099-2 2008 Myo-inositol is taken up by the sodium-myo-inositol-transporter SMIT1 (SLC5A3) expressed in a wide variety of cell types. Inositol 0-12 solute carrier family 5 member 3 S homeolog Xenopus laevis 64-69 18202099-2 2008 Myo-inositol is taken up by the sodium-myo-inositol-transporter SMIT1 (SLC5A3) expressed in a wide variety of cell types. Inositol 0-12 solute carrier family 5 member 3 Rattus norvegicus 71-77 18202099-6 2008 As demonstrated by two-electrode voltage-clamp in the Xenopus oocyte expression system, SMIT1-mediated myo-inositol-induced currents are up-regulated by coexpression of wild type SGK1 and constitutively active (S422D)SGK1 but not by inactive (K127N)SGK1. Inositol 103-115 solute carrier family 5 member 3 S homeolog Xenopus laevis 88-93 18202099-6 2008 As demonstrated by two-electrode voltage-clamp in the Xenopus oocyte expression system, SMIT1-mediated myo-inositol-induced currents are up-regulated by coexpression of wild type SGK1 and constitutively active (S422D)SGK1 but not by inactive (K127N)SGK1. Inositol 103-115 serum/glucocorticoid regulated kinase 1 L homeolog Xenopus laevis 179-183 18202099-6 2008 As demonstrated by two-electrode voltage-clamp in the Xenopus oocyte expression system, SMIT1-mediated myo-inositol-induced currents are up-regulated by coexpression of wild type SGK1 and constitutively active (S422D)SGK1 but not by inactive (K127N)SGK1. Inositol 103-115 serum/glucocorticoid regulated kinase 1 L homeolog Xenopus laevis 217-221 18202099-6 2008 As demonstrated by two-electrode voltage-clamp in the Xenopus oocyte expression system, SMIT1-mediated myo-inositol-induced currents are up-regulated by coexpression of wild type SGK1 and constitutively active (S422D)SGK1 but not by inactive (K127N)SGK1. Inositol 103-115 serum/glucocorticoid regulated kinase 1 L homeolog Xenopus laevis 217-221 18330477-0 2008 Free cholesterol-induced macrophage apoptosis is mediated by inositol-requiring enzyme 1 alpha-regulated activation of Jun N-terminal kinase. Inositol 61-69 mitogen-activated protein kinase 8 Homo sapiens 119-140 18330477-3 2008 Inositol-requiring enzyme 1 alpha (IRE1alpha) is an integral membrane protein of the ER that is a key signaling step in cholesterol-induced apoptosis in macrophages, activated by stress in the ER. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 35-44 18192687-5 2008 Upon dietary administration of a combination of N-acetyl-S-(N-2-phenethylthiocarbamoyl)-L-cysteine plus myo-inositol or indole-3-carbinol to carcinogen-treated mice, the relative abundance of 60S ribosomal protein L4 and carbonic anhydrase in tumor tissues decreased whereas that of histones, glutathione S-transferases mu, receptor advanced glycation end product, transglutaminase, and procollagen VI increased. Inositol 104-116 ribosomal protein L4 Mus musculus 192-216 18355727-6 2008 We now report that IP6K synthesizes both pyrophosphate (diphospho) as well as triphospho groups on the inositol ring. Inositol 103-111 diphosphoinositol pentakisphosphate kinase 1 Homo sapiens 19-23 18335328-9 2008 RESULTS: After 12 weeks of MYO administration plasma LH, PRL, T, insulin levels and LH/FSH resulted significantly reduced. Inositol 27-30 prolactin Homo sapiens 57-60 18335328-9 2008 RESULTS: After 12 weeks of MYO administration plasma LH, PRL, T, insulin levels and LH/FSH resulted significantly reduced. Inositol 27-30 insulin Homo sapiens 65-72 17562554-3 2008 To assign changes in MI to specific tissue pathology, the normalized peak and mean concentrations of MI were correlated with TMA and tCr concentrations. Inositol 101-103 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 133-136 17562554-8 2008 As increased MI and tCr concentrations were found in gliomatosis and other cerebral diseases associated with marked astrogliosis, this process may also be responsible for the observed changes in MI in other glial tumors. Inositol 195-197 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 20-23 18220422-2 2008 PTEN encodes a phosphatidylinositol phosphate phosphatase specific for the 3-position of the inositol ring. Inositol 27-35 phosphatase and tensin homolog Homo sapiens 0-4 18003640-4 2008 In this study, we present a Fkbp8 mouse mutant that has an isolated and completely penetrant spina bifida, which is folate- and inositol-resistant. Inositol 128-136 FK506 binding protein 8 Mus musculus 28-33 18189424-5 2008 Phospholipids with choline and inositol head groups and one or more linoleic acid (LA) acyl chains were shown to stimulate apoA-I secretion by HepG2 cells and primary human hepatocytes. Inositol 31-39 apolipoprotein A1 Homo sapiens 123-129 17460611-8 2008 In conclusion the IMPA1-/- mouse represents a novel model to study inositol homeostasis, and indicates that genetic inactivation of IMPA1 can mimic some actions of lithium. Inositol 67-75 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 18-23 18065557-9 2008 Recombinant AtPAP15 also showed enzyme activity on the substrate myoinositol-1-phosphate, indicating that the AtPAP15 is a phytase that hydrolyzes myoinositol hexakisphosphate to yield myoinositol and free phosphate. Inositol 65-76 purple acid phosphatase 15 Arabidopsis thaliana 12-19 18065557-9 2008 Recombinant AtPAP15 also showed enzyme activity on the substrate myoinositol-1-phosphate, indicating that the AtPAP15 is a phytase that hydrolyzes myoinositol hexakisphosphate to yield myoinositol and free phosphate. Inositol 65-76 purple acid phosphatase 15 Arabidopsis thaliana 110-117 18065557-11 2008 Thus, AtPAP15 may modulate AsA levels by controlling the input of myoinositol into this branch of AsA biosynthesis in Arabidopsis. Inositol 66-77 purple acid phosphatase 15 Arabidopsis thaliana 6-13 18161994-4 2008 However, inositol hexakisphosphate (IP6), a fairly abundant form of inositol in the cytoplasm, greatly facilitates self-association of arrestin2. Inositol 9-17 arrestin beta 1 Homo sapiens 135-144 17921520-3 2008 Recently, we demonstrated that lithium induces mTOR-independent autophagy by inhibiting inositol monophosphatase (IMPase) and reducing inositol and IP3 levels. Inositol 88-96 mechanistic target of rapamycin kinase Homo sapiens 47-51 17921520-3 2008 Recently, we demonstrated that lithium induces mTOR-independent autophagy by inhibiting inositol monophosphatase (IMPase) and reducing inositol and IP3 levels. Inositol 135-143 mechanistic target of rapamycin kinase Homo sapiens 47-51 18603618-2 2008 MIPS is an essential enzyme for production of inositol and inositol phosphates via its circularization of glucose-6-phosphate as the initial step. Inositol 46-54 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 0-4 19001750-4 2008 We identified GWT1 as a new anti-fungal drug candidate target and elucidated its function as being involved in the acylation of the inositol ring. Inositol 132-140 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 14-18 17963691-4 2007 When several lysine residues in the MSP domain were substituted for alanine, the resulting mutant Scs2 proteins lost the phosphoinositide-binding ability and failed to complement the inositol auxotrophy of an scs2 deletion strain. Inositol 183-191 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 98-102 17932225-0 2007 SMIT2 mediates all myo-inositol uptake in apical membranes of rat small intestine. Inositol 19-31 solute carrier family 5 member 11 Rattus norvegicus 0-5 17932225-3 2007 Through inhibition studies using selective substrates such as d-chiro-inositol (DCI, specific for SMIT2) and l-fucose (specific for SMIT1), we show that SMIT2 is exclusively responsible for apical MI transport in rat intestine; rabbit intestine appears to lack apical transport of MI. Inositol 62-78 solute carrier family 5 member 11 Rattus norvegicus 98-103 17932225-3 2007 Through inhibition studies using selective substrates such as d-chiro-inositol (DCI, specific for SMIT2) and l-fucose (specific for SMIT1), we show that SMIT2 is exclusively responsible for apical MI transport in rat intestine; rabbit intestine appears to lack apical transport of MI. Inositol 62-78 solute carrier family 5 member 11 Rattus norvegicus 153-158 18020950-3 2007 HaCaT cells osmo-dependently express mRNA specific for transport proteins for betaine (BGT-1), myo-inositol (SMIT) and taurine (TAUT). Inositol 95-107 solute carrier family 5 member 3 Homo sapiens 109-113 19002999-0 2007 Rat L6 myotubes as an in vitro model system to study GLUT4-dependent glucose uptake stimulated by inositol derivatives. Inositol 98-106 solute carrier family 2 member 4 Rattus norvegicus 53-58 19002999-4 2007 Immunoblot analyses revealed that at least D: -chiro-inositol, L: -chiro-inositol, epi-inositol, muco-inositol and D: -pinitol were able to induce translocation of glucose transporter 4 (GLUT4) to plasma membrane not only in L6 myotubes but also in skeletal muscles of rats ex vivo. Inositol 83-95 solute carrier family 2 member 4 Rattus norvegicus 164-185 19002999-4 2007 Immunoblot analyses revealed that at least D: -chiro-inositol, L: -chiro-inositol, epi-inositol, muco-inositol and D: -pinitol were able to induce translocation of glucose transporter 4 (GLUT4) to plasma membrane not only in L6 myotubes but also in skeletal muscles of rats ex vivo. Inositol 83-95 solute carrier family 2 member 4 Rattus norvegicus 187-192 19002999-4 2007 Immunoblot analyses revealed that at least D: -chiro-inositol, L: -chiro-inositol, epi-inositol, muco-inositol and D: -pinitol were able to induce translocation of glucose transporter 4 (GLUT4) to plasma membrane not only in L6 myotubes but also in skeletal muscles of rats ex vivo. Inositol 97-110 solute carrier family 2 member 4 Rattus norvegicus 164-185 19002999-4 2007 Immunoblot analyses revealed that at least D: -chiro-inositol, L: -chiro-inositol, epi-inositol, muco-inositol and D: -pinitol were able to induce translocation of glucose transporter 4 (GLUT4) to plasma membrane not only in L6 myotubes but also in skeletal muscles of rats ex vivo. Inositol 97-110 solute carrier family 2 member 4 Rattus norvegicus 187-192 19002999-5 2007 These results demonstrated that L6 myotubes appeared efficient as an in vitro system to identify inositol derivatives exerting an insulin-like effect on muscle cells depending on the induced translocation of GLUT4. Inositol 97-105 solute carrier family 2 member 4 Rattus norvegicus 208-213 17952759-2 2007 In addition, 30-40% of PCOS women have impaired glucose tolerance, and a defect in the insulin signaling pathway (inositol-containing phosphoglycan mediators) seems to be implicated in the pathogenesis of insulin resistance. Inositol 114-122 insulin Homo sapiens 87-94 17952759-2 2007 In addition, 30-40% of PCOS women have impaired glucose tolerance, and a defect in the insulin signaling pathway (inositol-containing phosphoglycan mediators) seems to be implicated in the pathogenesis of insulin resistance. Inositol 114-122 insulin Homo sapiens 205-212 17952759-4 2007 We hypothesized that the administration of an isoform of inositol (myo-inositol), belonging to the vitamin B complex, would improve the insulin-receptor activity, restoring normal ovulatory function. Inositol 57-65 insulin receptor Homo sapiens 136-152 17952759-4 2007 We hypothesized that the administration of an isoform of inositol (myo-inositol), belonging to the vitamin B complex, would improve the insulin-receptor activity, restoring normal ovulatory function. Inositol 67-79 insulin receptor Homo sapiens 136-152 17537518-3 2007 A family of putative insulin mediators, namely inositol phosphoglycans, were described to exert many insulin-like effects on lipid and glucose metabolism. Inositol 47-55 insulin Homo sapiens 21-28 17537518-3 2007 A family of putative insulin mediators, namely inositol phosphoglycans, were described to exert many insulin-like effects on lipid and glucose metabolism. Inositol 47-55 insulin Homo sapiens 101-108 17951450-7 2007 Expression of AtINT2 in a Deltaitr1 (inositol uptake)/Deltaino1 (inositol biosynthesis) double mutant of bakers" yeast complemented the deficiency of this mutant to grow on low concentrations of myoinositol. Inositol 37-45 inositol transporter 2 Arabidopsis thaliana 14-20 17951450-7 2007 Expression of AtINT2 in a Deltaitr1 (inositol uptake)/Deltaino1 (inositol biosynthesis) double mutant of bakers" yeast complemented the deficiency of this mutant to grow on low concentrations of myoinositol. Inositol 65-73 inositol transporter 2 Arabidopsis thaliana 14-20 17951450-7 2007 Expression of AtINT2 in a Deltaitr1 (inositol uptake)/Deltaino1 (inositol biosynthesis) double mutant of bakers" yeast complemented the deficiency of this mutant to grow on low concentrations of myoinositol. Inositol 195-206 inositol transporter 2 Arabidopsis thaliana 14-20 17951450-8 2007 In oocytes, AtINT2 mediated the symport of H(+) and several inositol epimers, such as myoinositol, scylloinositol, d-chiroinositol, and mucoinositol. Inositol 60-68 inositol transporter 2 Arabidopsis thaliana 12-18 17951450-8 2007 In oocytes, AtINT2 mediated the symport of H(+) and several inositol epimers, such as myoinositol, scylloinositol, d-chiroinositol, and mucoinositol. Inositol 86-97 inositol transporter 2 Arabidopsis thaliana 12-18 17951450-10 2007 Moreover, AtINT2 has a lower affinity for myoinositol (K(m) = 0.7-1.0 mm) than AtINT4 (K(m) = 0.24 mm), and the K(m) is slightly voltage dependent, which was not observed for AtINT4. Inositol 42-53 inositol transporter 2 Arabidopsis thaliana 10-16 17951450-10 2007 Moreover, AtINT2 has a lower affinity for myoinositol (K(m) = 0.7-1.0 mm) than AtINT4 (K(m) = 0.24 mm), and the K(m) is slightly voltage dependent, which was not observed for AtINT4. Inositol 42-53 inositol transporter 4 Arabidopsis thaliana 175-181 19812714-5 2007 The OPI1 gene product is a negative regulatory factor that controls the transcription of the INO1 structural gene, which encodes the enzyme catalyzing the limiting step in the biosynthesis of inositol, that is, the conversion of glucose-6-phosphate to inositol-3-phosphate. Inositol 192-200 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 4-8 19812714-5 2007 The OPI1 gene product is a negative regulatory factor that controls the transcription of the INO1 structural gene, which encodes the enzyme catalyzing the limiting step in the biosynthesis of inositol, that is, the conversion of glucose-6-phosphate to inositol-3-phosphate. Inositol 192-200 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 93-97 19812714-6 2007 Upon the deletion of the OPI1 gene, the cell will constitutively produce inositol, regardless of the extracellular inositol concentration. Inositol 73-81 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 25-29 19812714-6 2007 Upon the deletion of the OPI1 gene, the cell will constitutively produce inositol, regardless of the extracellular inositol concentration. Inositol 115-123 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 25-29 19812714-9 2007 The opi1 strain, with the ability to constitutively produce inositol regardless of media composition, showed less inhibition of cell growth in the presence of ethanol than did the wild-type strain, particularly in inositol-free media. Inositol 60-68 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 4-8 19812714-9 2007 The opi1 strain, with the ability to constitutively produce inositol regardless of media composition, showed less inhibition of cell growth in the presence of ethanol than did the wild-type strain, particularly in inositol-free media. Inositol 214-222 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 4-8 19812714-10 2007 We conclude that the introduction of an opi1 mutation in yeast results in an inherent increase in PI levels and constitutive biosynthesis of inositol that, in turn, will reduce the cost of supplementing inositol into the media to achieve a higher ethanol tolerance. Inositol 141-149 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 40-44 19812714-10 2007 We conclude that the introduction of an opi1 mutation in yeast results in an inherent increase in PI levels and constitutive biosynthesis of inositol that, in turn, will reduce the cost of supplementing inositol into the media to achieve a higher ethanol tolerance. Inositol 203-211 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 40-44 17711852-2 2007 Previously, we identified PGAP1 (post GPI attachment to proteins 1) as a GPI inositoldeacylase that removes the palmitate from inositol. Inositol 77-85 post-GPI attachment to proteins 1 Mus musculus 26-31 17711852-2 2007 Previously, we identified PGAP1 (post GPI attachment to proteins 1) as a GPI inositoldeacylase that removes the palmitate from inositol. Inositol 77-85 post-GPI attachment to proteins 1 Mus musculus 33-66 17593018-3 2007 In the present study, we show that transcription of the INO1 gene, which encodes inositol-3-phosphate synthase, cannot be fully repressed by inositol and choline, and UAS(INO1) (inositol-sensitive upstream activating sequence)-driven transcription is enhanced in Acb1p-depleted cells. Inositol 81-89 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 56-60 17593018-3 2007 In the present study, we show that transcription of the INO1 gene, which encodes inositol-3-phosphate synthase, cannot be fully repressed by inositol and choline, and UAS(INO1) (inositol-sensitive upstream activating sequence)-driven transcription is enhanced in Acb1p-depleted cells. Inositol 81-89 long-chain fatty acid transporter ACB1 Saccharomyces cerevisiae S288C 263-268 17593018-3 2007 In the present study, we show that transcription of the INO1 gene, which encodes inositol-3-phosphate synthase, cannot be fully repressed by inositol and choline, and UAS(INO1) (inositol-sensitive upstream activating sequence)-driven transcription is enhanced in Acb1p-depleted cells. Inositol 141-149 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 56-60 17593018-4 2007 In addition, the reduction in inositol-mediated repression of INO1 transcription observed after depletion of Acb1p appeared to be independent of the transcriptional repressor, Opi1p. Inositol 30-38 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 62-66 17593018-4 2007 In addition, the reduction in inositol-mediated repression of INO1 transcription observed after depletion of Acb1p appeared to be independent of the transcriptional repressor, Opi1p. Inositol 30-38 long-chain fatty acid transporter ACB1 Saccharomyces cerevisiae S288C 109-114 17707174-4 2007 Relative to the creatine/phosphocreatine peak, BCS lesions displayed decreases of N-acetyl aspartate and increases of choline, myo-inositol (mI), glutamine/glutamate (Glx), lactate and lipid+macromolecule signals, in agreement with previous reports. Inositol 127-139 BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Homo sapiens 47-50 17707174-4 2007 Relative to the creatine/phosphocreatine peak, BCS lesions displayed decreases of N-acetyl aspartate and increases of choline, myo-inositol (mI), glutamine/glutamate (Glx), lactate and lipid+macromolecule signals, in agreement with previous reports. Inositol 141-143 BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Homo sapiens 47-50 17707174-5 2007 In addition, previously unreported decreases of mI (-19% to -29%) and increases of Glx (+55% to +198%) were measured; these could be useful in characterizing BCS lesions. Inositol 48-50 BCS1 homolog, ubiquinol-cytochrome c reductase complex chaperone Homo sapiens 158-161 17588177-1 2007 In the yeast Saccharomyces cerevisiae, structural genes of phospholipid biosynthesis are activated by a heterodimer of basic helix-loop-helix proteins, Ino2 and Ino4, which bind to the inositol/choline-responsive element (ICRE) UAS element. Inositol 185-193 Ino2p Saccharomyces cerevisiae S288C 152-156 17588177-1 2007 In the yeast Saccharomyces cerevisiae, structural genes of phospholipid biosynthesis are activated by a heterodimer of basic helix-loop-helix proteins, Ino2 and Ino4, which bind to the inositol/choline-responsive element (ICRE) UAS element. Inositol 185-193 Ino4p Saccharomyces cerevisiae S288C 161-165 17526578-1 2007 Ca2+ liberation through inositol 1,4,5-trisphosphate receptor (IP3R) channels generates complex patterns of spatiotemporal cellular Ca2+ signals owing to the biphasic modulation of channel gating by Ca2+ itself. Inositol 24-32 inositol 1,4,5-trisphosphate receptor type 1 S homeolog Xenopus laevis 63-67 17464326-8 2007 CdCl(2) also triggered activation of the inositol-requiring ER-to-nucleus signal kinase 1 (IRE1)-X-box-binding protein 1 (XBP1) pathway and inhibition of XBP1 attenuated apoptosis independent of GRP78 and CHOP. Inositol 41-49 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 91-95 17464326-8 2007 CdCl(2) also triggered activation of the inositol-requiring ER-to-nucleus signal kinase 1 (IRE1)-X-box-binding protein 1 (XBP1) pathway and inhibition of XBP1 attenuated apoptosis independent of GRP78 and CHOP. Inositol 41-49 X-box binding protein 1 Homo sapiens 97-120 17464326-8 2007 CdCl(2) also triggered activation of the inositol-requiring ER-to-nucleus signal kinase 1 (IRE1)-X-box-binding protein 1 (XBP1) pathway and inhibition of XBP1 attenuated apoptosis independent of GRP78 and CHOP. Inositol 41-49 X-box binding protein 1 Homo sapiens 122-126 17464326-8 2007 CdCl(2) also triggered activation of the inositol-requiring ER-to-nucleus signal kinase 1 (IRE1)-X-box-binding protein 1 (XBP1) pathway and inhibition of XBP1 attenuated apoptosis independent of GRP78 and CHOP. Inositol 41-49 heat shock protein family A (Hsp70) member 5 Homo sapiens 195-200 17464326-8 2007 CdCl(2) also triggered activation of the inositol-requiring ER-to-nucleus signal kinase 1 (IRE1)-X-box-binding protein 1 (XBP1) pathway and inhibition of XBP1 attenuated apoptosis independent of GRP78 and CHOP. Inositol 41-49 DNA damage inducible transcript 3 Homo sapiens 205-209 17451429-1 2007 Lithium is a therapeutic agent commonly used to treat bipolar disorder and its beneficial effects are thought to be due to a combination of activation of the Wnt/beta-catenin pathway via inhibition of glycogen synthase kinase-3beta and depletion of the inositol pool via inhibition of the inositol monophosphatase-1. Inositol 253-261 catenin beta 1 Bos taurus 162-174 17650583-0 2007 Added inositol regulates invertase secretion and glucose-repressed SUC2 gene expression in Saccharomyces sp. Inositol 6-14 beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C 67-71 17650583-2 2007 The effect of inositol supplementation on glucose derepression, invertase secretion and SUC2 gene expression in Saccharomyces sp. Inositol 14-22 beta-fructofuranosidase SUC2 Saccharomyces cerevisiae S288C 88-92 17417879-4 2007 Trimeric neck-carbohydrate recognition domains (NCRDs) of rat and human SP-D exhibited dose-dependent, calcium-dependent, and inositol-sensitive binding to solid-phase PI and to multilamellar PI liposomes. Inositol 126-134 surfactant protein D Homo sapiens 72-76 16947021-6 2007 Among the tested PtdIns-homologues those with a phosphate esterified to position 3 of the inositol head group, were most efficient in cooperating with bv-sPLA2 to block tumour cell proliferation. Inositol 90-98 phospholipase A2 group X Homo sapiens 154-159 17380188-4 2007 All four subunits are induced simultaneously by endoplasmic reticulum stresses from the X-box-binding protein 1/inositol-requiring 1alpha pathway. Inositol 112-120 X-box binding protein 1 Homo sapiens 88-111 17371235-1 2007 The lipid phosphatase, PTEN (phosphatase and tensin homologue deleted on chromosome 10), is the product of a major tumour suppressor gene that antagonizes PI3K (phosphoinositide 3-kinase) signalling by dephosphorylating the 3-position of the inositol ring of PtdIns(3,4,5)P(3). Inositol 242-250 phosphatase and tensin homolog Mus musculus 23-27 17371235-1 2007 The lipid phosphatase, PTEN (phosphatase and tensin homologue deleted on chromosome 10), is the product of a major tumour suppressor gene that antagonizes PI3K (phosphoinositide 3-kinase) signalling by dephosphorylating the 3-position of the inositol ring of PtdIns(3,4,5)P(3). Inositol 242-250 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 161-186 17371253-2 2007 In dephosphorylating the 3-position of the inositol ring of phosphoinositides such as PtdIns(3,4,5)P(3), PTEN"s lipid phosphatase activity is an important counteracting mechanism in PI3K (phosphoinositide 3-kinase) signalling. Inositol 43-51 phosphatase and tensin homolog Homo sapiens 105-109 17314402-7 2007 We also show that the remodeling requires the preceding PGAP1-mediated deacylation from inositol of GPI-APs in the endoplasmic reticulum. Inositol 88-96 GPI inositol-deacylase Cricetulus griseus 56-61 17081670-3 2007 Patients with increased S100B levels showed elevated myo-inositol concentrations. Inositol 53-65 S100 calcium binding protein B Homo sapiens 24-29 16781190-6 2007 A permease encoded by the GIT1 gene imports extracellular glycerophosphodiesters across the plasma membrane, where their hydrolytic products can provide crucial nutrients such as inositol, choline, and phosphate to the cell. Inositol 179-187 Git1p Saccharomyces cerevisiae S288C 26-30 16807089-8 2007 In contrast, the negative regulatory protein Opi1p, which is involved in inositol-mediated regulation of phospholipid synthesis, represses the expression of the CHO1 gene through the cis-acting element UAS(INO). Inositol 73-81 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 45-50 16807089-8 2007 In contrast, the negative regulatory protein Opi1p, which is involved in inositol-mediated regulation of phospholipid synthesis, represses the expression of the CHO1 gene through the cis-acting element UAS(INO). Inositol 73-81 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 161-165 17237190-10 2007 By labeling the endogenous myoinositol pool in 5ptase1 and 5ptase2 mutants, we detected increases in Ins(1,4,5)P(3) and a decrease in PtdIns, PtdIns(4)P, and phosphatidylinositol (4,5) bisphosphate. Inositol 27-38 myo-inositol polyphosphate 5-phosphatase 2 Arabidopsis thaliana 47-66 17237190-11 2007 Taken together, these data indicate that the At5PTase1 and At5PTase2 genes have nonredundant roles in hydrolyzing inositol second-messenger substrates and that regulation of Ins(1,4,5)P(3) levels is important during germination and early seedling development. Inositol 114-122 inositol polyphosphate 5-phosphatase I Arabidopsis thaliana 45-54 17237190-11 2007 Taken together, these data indicate that the At5PTase1 and At5PTase2 genes have nonredundant roles in hydrolyzing inositol second-messenger substrates and that regulation of Ins(1,4,5)P(3) levels is important during germination and early seedling development. Inositol 114-122 myo-inositol polyphosphate 5-phosphatase 2 Arabidopsis thaliana 59-68 17709894-0 2007 Effect of prolactin on inositol uptake in mouse mammary gland explants. Inositol 23-31 prolactin Mus musculus 10-19 17709894-1 2007 Studies were carried out to assess the role of insulin (I), cortisol (H), and prolactin (P or PRL) in regulating myoinositol (inositol) uptake in the mammary gland. Inositol 113-124 prolactin Mus musculus 78-87 17709894-1 2007 Studies were carried out to assess the role of insulin (I), cortisol (H), and prolactin (P or PRL) in regulating myoinositol (inositol) uptake in the mammary gland. Inositol 113-124 prolactin Mus musculus 94-97 17709894-1 2007 Studies were carried out to assess the role of insulin (I), cortisol (H), and prolactin (P or PRL) in regulating myoinositol (inositol) uptake in the mammary gland. Inositol 116-124 prolactin Mus musculus 78-87 17709894-1 2007 Studies were carried out to assess the role of insulin (I), cortisol (H), and prolactin (P or PRL) in regulating myoinositol (inositol) uptake in the mammary gland. Inositol 116-124 prolactin Mus musculus 94-97 17709894-2 2007 Using cultured mammary gland explants from pregnant mice (12-14 days into gestation), insulin and prolactin were found to stimulate inositol uptake, while cortisol impaired inositol uptake. Inositol 132-140 prolactin Mus musculus 98-107 17709894-2 2007 Using cultured mammary gland explants from pregnant mice (12-14 days into gestation), insulin and prolactin were found to stimulate inositol uptake, while cortisol impaired inositol uptake. Inositol 173-181 prolactin Mus musculus 98-107 17709894-3 2007 Optimal inositol uptake was observed when tissues were treated with all three lactogenic hormones (I, H, and PRL). Inositol 8-16 prolactin Mus musculus 109-112 17709894-4 2007 Further studies were designed primarily to characterize the PRL stimulation of inositol transport. Inositol 79-87 prolactin Mus musculus 60-63 17709894-6 2007 The PRL effect on inositol uptake is sodium-dependent, temperature-dependent, and ouabain sensitive. Inositol 18-26 prolactin Mus musculus 4-7 17709894-8 2007 PRL stimulated inositol uptake employing PRL concentrations of 10-1000 ng/ml. Inositol 15-23 prolactin Mus musculus 0-3 17709894-8 2007 PRL stimulated inositol uptake employing PRL concentrations of 10-1000 ng/ml. Inositol 15-23 prolactin Mus musculus 41-44 17709894-10 2007 PRL thus appears to be an important and essential hormone for the stimulation of inositol accumulation in milk during lactogenesis. Inositol 81-89 prolactin Mus musculus 0-3 16420717-1 2007 Recent in-vitro data indicate that depletion of neural cells of myo-inositol by virtue of down-regulation of the high-affinity sodium-myo-inositol co-transporter (SMIT) may be a common mechanism of action of the mood stabilizers lithium, valproate and carbamazepine. Inositol 64-76 solute carrier family 5 member 3 Homo sapiens 163-167 17257308-0 2007 Glycogen synthase kinase-3 is required for optimal de novo synthesis of inositol. Inositol 72-80 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 0-26 17257308-1 2007 Studies have shown that the inositol biosynthetic pathway and the enzyme glycogen synthase kinase-3 (GSK-3) are targets of the mood-stabilizing drugs lithium and valproate. Inositol 28-36 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 73-99 17257308-1 2007 Studies have shown that the inositol biosynthetic pathway and the enzyme glycogen synthase kinase-3 (GSK-3) are targets of the mood-stabilizing drugs lithium and valproate. Inositol 28-36 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 101-106 17257308-3 2007 We hypothesized that GSK-3 may play a role in inositol synthesis, and that loss of GSK-3 may lead to inositol depletion, thus providing a mechanistic link between the two drug targets. Inositol 46-54 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 21-26 17257308-3 2007 We hypothesized that GSK-3 may play a role in inositol synthesis, and that loss of GSK-3 may lead to inositol depletion, thus providing a mechanistic link between the two drug targets. Inositol 101-109 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 83-88 17257308-9 2007 These results demonstrate for the first time that GSK-3 is required for optimal myo-inositol-3 phosphate synthase activity and de novo inositol biosynthesis, and that loss of GSK-3 activity causes inositol depletion. Inositol 84-92 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 50-55 17257308-9 2007 These results demonstrate for the first time that GSK-3 is required for optimal myo-inositol-3 phosphate synthase activity and de novo inositol biosynthesis, and that loss of GSK-3 activity causes inositol depletion. Inositol 135-143 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 50-55 17233578-1 2007 The original hypothesis put forth by Bob Michell in his seminal 1975 review held that inositol lipid breakdown was involved in the activation of plasma membrane calcium channels or "gates". Inositol 86-94 Brother of Bearded A Drosophila melanogaster 37-40 17233578-10 2007 Thus the TRPCs represent a family of ion channels that are directly activated by inositol lipid breakdown, confirming Bob Michell"s original prediction 30 years ago. Inositol 81-89 Brother of Bearded A Drosophila melanogaster 118-121 17982259-6 2007 The H(2)O(2)-induced [Ca(2+)](i) rise was prevented by the generic phospholipase C (PLC) inhibitor U73122 and the inositol 1,4,5-trisphosphate-receptor (IP(3)R) blocker 2-APB. Inositol 114-122 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 153-159 17664885-2 2007 Inositol phosphoglycan A-type (A-IPG), a putative second messenger of insulin, was reported to regulate lipogenesis in adipose tissue. Inositol 0-8 insulin Homo sapiens 70-77 17116762-2 2007 Recently, inositol phosphoglycan P-type, a putative second messenger of insulin action, has been implicated in the pathophysiology of preeclampsia and is increased in the placenta, amniotic fluid, and maternal urine of preeclamptic women compared with normal pregnant women. Inositol 10-18 insulin Homo sapiens 72-79 17525076-2 2007 The de novo synthesis of myo-inositol requires the activity of the enzyme D-myo-inositol-3-phosphate synthase (MIPS). Inositol 25-37 myo-inositol-3-phosphate synthase Glycine max 74-109 17954247-2 2007 In mammalian cells, PI(4,5)P(2) is synthesized predominantly by phosphatidylinositol 4-phosphate [PI(4)P] 5-kinase (PIP5K) through phosphorylation of PI(4)P at the D-5 position of the inositol ring. Inositol 76-84 phosphoinositide kinase, FYVE-type zinc finger containing Homo sapiens 116-121 18217361-0 2007 [The influence of myo-inositol on the ultrastructure of hippocampal CA1 area in kainate treated rats]. Inositol 18-30 carbonic anhydrase 1 Rattus norvegicus 68-71 18217361-1 2007 The ultrastructure of neurons, synapses and astrocytes of hippocampal CA1 area in rats was investigated 14 days after: systemic injection of kainic acid and kainic acid and myo-Inositol. Inositol 173-185 carbonic anhydrase 1 Rattus norvegicus 70-73 17050532-7 2006 The ATP binding site is similar in both enzymes; however, the inositol binding domain is significantly smaller in Ipk2. Inositol 62-70 inositol polyphosphate multikinase Saccharomyces cerevisiae S288C 114-118 17158747-3 2006 In a screen for thermotaxis mutants, we identified the gene ttx-7, which encodes myo-inositol monophosphatase (IMPase), an inositol-producing enzyme regarded as a bipolar disorder-relevant molecule for its lithium sensitivity. Inositol 85-93 Inositol monophosphatase ttx-7 Caenorhabditis elegans 60-65 17158747-5 2006 Both behavioral and localization defects in ttx-7 mutants were rescued by expression of IMPase in adults and by inositol application, and the same defects were mimicked by lithium treatment in wild-type animals. Inositol 112-120 Inositol monophosphatase ttx-7 Caenorhabditis elegans 44-49 16985167-1 2006 2-Aminoethoxydiphenyl borate (2-APB), an inositol 1,4,5-triphosphate receptor modulator, inhibits capacitive current transients measured in normal rat kidney and human embryonic kidney 293 cells, an indication of blocking gap junction channels between these cells. Inositol 41-49 arginyl aminopeptidase Rattus norvegicus 32-35 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Inositol 42-50 arginyl aminopeptidase Homo sapiens 2-5 17130674-5 2006 2-APB [(2-aminoethoxy)diphenylborane], an inositol 1,4,5-trisphosphate (IP(3))-receptor antagonist, inhibited UTP-induced IL-6 mRNA expression; and the action of A23187, a Ca(2+) ionophore, resembled the action of UTP. Inositol 42-50 interleukin 6 Homo sapiens 122-126 17090927-1 2006 Yeast Ino2p-Ino4p heterodimeric complex is well known as a transcriptional activator for the genes regulated by inositol and choline, such as the INO1 gene. Inositol 112-120 Ino2p Saccharomyces cerevisiae S288C 6-11 17090927-1 2006 Yeast Ino2p-Ino4p heterodimeric complex is well known as a transcriptional activator for the genes regulated by inositol and choline, such as the INO1 gene. Inositol 112-120 Ino4p Saccharomyces cerevisiae S288C 12-17 17090927-1 2006 Yeast Ino2p-Ino4p heterodimeric complex is well known as a transcriptional activator for the genes regulated by inositol and choline, such as the INO1 gene. Inositol 112-120 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 146-150 17073300-9 2006 This iterative bioinformatic-experimental approach to a comprehensive analysis of the HrpL regulon revealed a mix of genes controlled by HrpL, including those encoding most type III effectors, twin-arginine transport (TAT) substrates, other regulatory proteins, and proteins involved in the synthesis or metabolism of phytohormones, phytotoxins, and myo-inositol. Inositol 350-362 RNA polymerase sigma factor HrpL Pseudomonas syringae pv. tomato str. DC3000 86-90 17073300-9 2006 This iterative bioinformatic-experimental approach to a comprehensive analysis of the HrpL regulon revealed a mix of genes controlled by HrpL, including those encoding most type III effectors, twin-arginine transport (TAT) substrates, other regulatory proteins, and proteins involved in the synthesis or metabolism of phytohormones, phytotoxins, and myo-inositol. Inositol 350-362 RNA polymerase sigma factor HrpL Pseudomonas syringae pv. tomato str. DC3000 137-141 17012379-2 2006 In animals, catabolism of MI and D-chiro-inositol depends on the enzyme MI oxygenase (MIOX), which catalyzes the first committed step of the glucuronate-xylulose pathway, and is found almost exclusively in the kidneys. Inositol 33-49 myo-inositol oxygenase Homo sapiens 72-84 17012379-2 2006 In animals, catabolism of MI and D-chiro-inositol depends on the enzyme MI oxygenase (MIOX), which catalyzes the first committed step of the glucuronate-xylulose pathway, and is found almost exclusively in the kidneys. Inositol 33-49 myo-inositol oxygenase Homo sapiens 86-90 17135500-4 2006 Group B, mAbs 2H3 and 4H10 only recognized re-PrP and PrP(Sc) of sheep, and especially, these two mAbs could not recognize PrP(C) from both bovine and sheep. Inositol 14-17 major prion protein Ovis aries 46-49 17135500-4 2006 Group B, mAbs 2H3 and 4H10 only recognized re-PrP and PrP(Sc) of sheep, and especially, these two mAbs could not recognize PrP(C) from both bovine and sheep. Inositol 14-17 major prion protein Ovis aries 54-57 16777852-5 2006 We also report that the unfolded protein response pathway is rapidly inactivated by inositol supplementation and demonstrate that the response of the unfolded protein response pathway to inositol is separable from the response mediated by Opi1p. Inositol 187-195 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 239-244 16895396-0 2006 Demonstration by 2H ENDOR spectroscopy that myo-inositol binds via an alkoxide bridge to the mixed-valent diiron center of myo-inositol oxygenase. Inositol 44-56 myo-inositol oxygenase Homo sapiens 127-145 16895396-1 2006 myo-Inositol oxygenase (MIOX) is a non-heme diiron oxygenase that cleaves cyclohexane-(1,2,3,5/4,6-hexa)-ol (myo-inositol, MI) to d-glucuronate. Inositol 109-121 myo-inositol oxygenase Homo sapiens 4-22 16895396-1 2006 myo-Inositol oxygenase (MIOX) is a non-heme diiron oxygenase that cleaves cyclohexane-(1,2,3,5/4,6-hexa)-ol (myo-inositol, MI) to d-glucuronate. Inositol 109-121 myo-inositol oxygenase Homo sapiens 24-28 16777854-5 2006 Phosphatidylcholine turnover increased rapidly following inositol addition, a response that requires the participation of Nte1p, an endoplasmic reticulum-localized phospholipase B. Inositol 57-65 lysophospholipase Saccharomyces cerevisiae S288C 122-127 16880565-1 2006 Myo-inositol oxygenase (MIOX) catalyzes the novel oxidative cleavage of myo-inositol (MI) and its epimer D-chiro inositol (DCI) to D-glucuronate. Inositol 72-84 myo-inositol oxygenase Mus musculus 0-22 16880565-1 2006 Myo-inositol oxygenase (MIOX) catalyzes the novel oxidative cleavage of myo-inositol (MI) and its epimer D-chiro inositol (DCI) to D-glucuronate. Inositol 72-84 myo-inositol oxygenase Mus musculus 24-28 16896211-5 2006 These genes included the INO1 gene, which encodes the myo-inositol-1-phosphate synthase, which carries out the rate-limiting step in inositol biosynthesis. Inositol 58-66 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 25-29 16767098-1 2006 When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Abeta pathology and accelerated mortality. Inositol 68-84 amyloid beta (A4) precursor protein Mus musculus 144-149 16767098-1 2006 When given orally to a transgenic mouse model of Alzheimer disease, cyclohexanehexol stereoisomers inhibit aggregation of amyloid beta peptide (Abeta) into high-molecular-weight oligomers in the brain and ameliorate several Alzheimer disease-like phenotypes in these mice, including impaired cognition, altered synaptic physiology, cerebral Abeta pathology and accelerated mortality. Inositol 68-84 amyloid beta (A4) precursor protein Mus musculus 341-346 16601118-5 2006 Surprisingly, myoinositol and all inositol phosphates tested were permeable through homomeric Cx32 and homomeric Cx26 channels. Inositol 14-25 gap junction protein beta 1 Homo sapiens 94-98 16601118-5 2006 Surprisingly, myoinositol and all inositol phosphates tested were permeable through homomeric Cx32 and homomeric Cx26 channels. Inositol 14-25 gap junction protein beta 2 Homo sapiens 113-117 16723396-8 2006 NMR spectrum analysis of the animals cerebrospinal fluid revealed a strong reduction trend in several metabolites in Abeta-infused rats, including lactate and myo-inositol, supporting the idea of dysfunctional astrocytes. Inositol 159-171 amyloid beta precursor protein Rattus norvegicus 117-122 16582425-4 2006 In the presence of inositol, PA levels decrease, releasing Opi1p into the nucleus where it represses transcription. Inositol 19-27 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 59-64 16582425-5 2006 The opi1 mutant overproduces and excretes inositol into the growth medium in the absence of inositol and choline (Opi(-) phenotype). Inositol 42-50 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 4-8 16582425-5 2006 The opi1 mutant overproduces and excretes inositol into the growth medium in the absence of inositol and choline (Opi(-) phenotype). Inositol 92-100 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 4-8 16634621-1 2006 myo-Inositol oxygenase (MIOX) catalyzes the ring-cleaving, four-electron oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate (myo-inositol, MI) to d-glucuronate (DG). Inositol 134-146 myo-inositol oxygenase Homo sapiens 4-22 16634621-1 2006 myo-Inositol oxygenase (MIOX) catalyzes the ring-cleaving, four-electron oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate (myo-inositol, MI) to d-glucuronate (DG). Inositol 134-146 myo-inositol oxygenase Homo sapiens 24-28 16645094-1 2006 Accumulation of misfolded protein in the endoplasmic reticulum (ER) triggers an adaptive stress response-termed the unfolded protein response (UPR)-mediated by the ER transmembrane protein kinase and endoribonuclease inositol-requiring enzyme-1alpha (IRE1alpha). Inositol 217-225 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 251-260 16606846-1 2006 myo-Inositol oxygenase (MIOX) activates O2 at a mixed-valent nonheme diiron(II/III) cluster to effect oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate [myo-inositol (MI)] by four electrons to d-glucuronate. Inositol 163-175 myo-inositol oxygenase Homo sapiens 4-22 16606846-1 2006 myo-Inositol oxygenase (MIOX) activates O2 at a mixed-valent nonheme diiron(II/III) cluster to effect oxidation of its cyclohexan-(1,2,3,4,5,6-hexa)-ol substrate [myo-inositol (MI)] by four electrons to d-glucuronate. Inositol 163-175 myo-inositol oxygenase Homo sapiens 24-28 16406061-0 2006 The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation. Inositol 26-34 inositol polyphosphate-5-phosphatase D Homo sapiens 49-54 16406061-0 2006 The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation. Inositol 26-34 Fc gamma receptor IIb Homo sapiens 108-119 16406061-0 2006 The SH2 domain-containing inositol 5-phosphatase SHIP1 is recruited to the intracytoplasmic domain of human FcgammaRIIB and is mandatory for negative regulation of B cell activation. Inositol 26-34 B cell linker Homo sapiens 164-181 16363994-2 2006 The PIS1 (phosphatidylinositol synthase gene) encoding the enzyme Pis1p which catalyses the synthesis of phosphatidylinositol from CDP-diacyglycerol and inositol, was isolated in a screen for multicopy suppressors of the rsp5 temperature sensitivity phenotype. Inositol 22-30 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 4-8 16363994-2 2006 The PIS1 (phosphatidylinositol synthase gene) encoding the enzyme Pis1p which catalyses the synthesis of phosphatidylinositol from CDP-diacyglycerol and inositol, was isolated in a screen for multicopy suppressors of the rsp5 temperature sensitivity phenotype. Inositol 22-30 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 66-71 16363994-2 2006 The PIS1 (phosphatidylinositol synthase gene) encoding the enzyme Pis1p which catalyses the synthesis of phosphatidylinositol from CDP-diacyglycerol and inositol, was isolated in a screen for multicopy suppressors of the rsp5 temperature sensitivity phenotype. Inositol 22-30 NEDD4 family E3 ubiquitin-protein ligase Saccharomyces cerevisiae S288C 221-225 16363994-6 2006 2-fold in the rsp5 mutant as compared with the wild-type, and that inositol added to the medium improved growth of rsp5 mutants at a restrictive temperature. Inositol 67-75 NEDD4 family E3 ubiquitin-protein ligase Saccharomyces cerevisiae S288C 115-119 16511884-5 2006 It was recently suggested that a relationship exists between VPA exposure and the cellular depletion of myo-inositol (INO). Inositol 118-121 synaptopodin 2 Mus musculus 104-107 16453359-6 2006 Here we report the introduction of myo-inositol, in place of alpha-D-glucose, in the sn-2 position of the glycerol backbone; this leads to two diastereomeric 1-O-octadecyl-2-O-(2-(myo-inositolyl)-ethyl)-sn-glycero-3-(R/S)-phosphatidylcholines (Ino-C2-PAF). Inositol 35-47 PCNA clamp associated factor Homo sapiens 251-254 16453359-7 2006 The inositol-containing PAF enhances the antiproliferative capacity (IC(50)=1.8 microM) and reduces the cytotoxicity relative to Glc-PAF (LC(50)=15 microM). Inositol 4-12 PCNA clamp associated factor Homo sapiens 24-27 16453359-7 2006 The inositol-containing PAF enhances the antiproliferative capacity (IC(50)=1.8 microM) and reduces the cytotoxicity relative to Glc-PAF (LC(50)=15 microM). Inositol 4-12 PCNA clamp associated factor Homo sapiens 133-136 16544270-10 2006 However, expression was elevated in an ino4delta mutant but not in ino2delta cells, suggesting multiple and separate functions for the inositol-responsive INO2/INO4 gene products, which normally function as a dimer in regulating gene function. Inositol 135-143 Ino2p Saccharomyces cerevisiae S288C 155-159 16544270-10 2006 However, expression was elevated in an ino4delta mutant but not in ino2delta cells, suggesting multiple and separate functions for the inositol-responsive INO2/INO4 gene products, which normally function as a dimer in regulating gene function. Inositol 135-143 Ino4p Saccharomyces cerevisiae S288C 160-164 16407309-2 2006 Opi1p repressor activity is most active in inositol-supplemented cells. Inositol 43-51 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 0-5 16407309-8 2006 Expression of the OPI1 allele in an opi1Delta mutant attenuated (2-fold) the repressive effect of Opi1p on INO1 expression, and this effect was only observed when cells were grown in the absence of inositol. Inositol 198-206 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 18-22 16407309-8 2006 Expression of the OPI1 allele in an opi1Delta mutant attenuated (2-fold) the repressive effect of Opi1p on INO1 expression, and this effect was only observed when cells were grown in the absence of inositol. Inositol 198-206 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 107-111 16407309-9 2006 These data supported the conclusion that casein kinase II phosphorylation at Ser10 played a role in stimulating the repression of INO1 when Opi1p was not in its most active state (i.e. in inositol-deprived cells). Inositol 188-196 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 130-134 16361252-3 2006 We previously isolated gwt1 mutants and found that GWT1 is required for inositol acylation in the GPI biosynthetic pathway. Inositol 72-80 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 23-27 16361252-3 2006 We previously isolated gwt1 mutants and found that GWT1 is required for inositol acylation in the GPI biosynthetic pathway. Inositol 72-80 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 51-55 16488989-2 2006 We recently identified the metastasis-associated protein CD24, a glycosyl phosphatidyl inositol-linked surface protein, as a downstream target of Ral signaling by profiling the expression of RalA/B-depleted bladder carcinoma cells. Inositol 87-95 CD24 molecule Homo sapiens 57-61 16488989-2 2006 We recently identified the metastasis-associated protein CD24, a glycosyl phosphatidyl inositol-linked surface protein, as a downstream target of Ral signaling by profiling the expression of RalA/B-depleted bladder carcinoma cells. Inositol 87-95 RAS like proto-oncogene A Homo sapiens 146-149 16461360-1 2006 Upon the accumulation of unfolded proteins in the mammalian endoplasmic reticulum (ER), X-box binding protein 1 (XBP1) premessenger RNA (premRNA) is converted to mature mRNA by unconventional splicing that is mediated by the endonuclease inositol-requiring enzyme 1. Inositol 238-246 X-box binding protein 1 Homo sapiens 88-111 16461360-1 2006 Upon the accumulation of unfolded proteins in the mammalian endoplasmic reticulum (ER), X-box binding protein 1 (XBP1) premessenger RNA (premRNA) is converted to mature mRNA by unconventional splicing that is mediated by the endonuclease inositol-requiring enzyme 1. Inositol 238-246 X-box binding protein 1 Homo sapiens 113-117 16443877-2 2006 We hypothesize that a deficiency in D-chiro-inositol (DCI) and/or a DCI-containing IPG (DCI-IPG) may contribute to insulin resistance in humans. Inositol 36-52 insulin Homo sapiens 115-122 16446504-1 2006 The Na+/glucose cotransporter (SGLT1) is an archetype for the SLC5 family, which is comprised of Na+-coupled transporters for sugars, myo-inositol, choline, and organic anions. Inositol 134-146 solute carrier family 5 member 1 Homo sapiens 31-36 16319176-0 2006 Inositol deacylation by Bst1p is required for the quality control of glycosylphosphatidylinositol-anchored proteins. Inositol 0-8 bone marrow stromal cell antigen 1 Homo sapiens 24-29 16106035-6 2006 Furthermore, under the same conditions, integrin alpha1-null cells show prolonged ERK1/2 phosphorylation and decreased inositol uptake compared with control cells. Inositol 119-127 integrin alpha 1 Mus musculus 40-55 16106035-7 2006 The reduction of inositol uptake is significantly reversed by treatment with the MEK inhibitor PD-98059. Inositol 17-25 midkine Mus musculus 81-84 16492584-0 2006 Inositol phosphoglycan putative insulin mediator in human amniotic fluid. Inositol 0-8 insulin Homo sapiens 32-39 17121275-1 2006 The first and rate-limiting step in the biosynthesis of myo-inositol is the conversion of D-glucose 6-phosphate to 1L-myo-inositol 1-phosphate catalyzed by 1L-myo-inositol 1-phosphate synthase (MIP synthase). Inositol 56-68 inositol-3-phosphate synthase 1 Homo sapiens 194-206 16221686-1 2005 In a genetic screen for Saccharomyces cerevisiae mutants hypersensitive to the inositol-depleting drugs lithium and valproate, a loss of function allele of TPI1 was identified. Inositol 79-87 triose-phosphate isomerase TPI1 Saccharomyces cerevisiae S288C 156-160 16221686-4 2005 The tpi1 mutant was unable to grow in the absence of inositol and exhibited the "inositol-less death" phenotype. Inositol 53-61 triose-phosphate isomerase TPI1 Saccharomyces cerevisiae S288C 4-8 16221686-4 2005 The tpi1 mutant was unable to grow in the absence of inositol and exhibited the "inositol-less death" phenotype. Inositol 81-89 triose-phosphate isomerase TPI1 Saccharomyces cerevisiae S288C 4-8 16221686-5 2005 Similarly, the pgk1 mutant, which accumulates DHAP as a result of defective conversion of 3-phosphoglyceroyl phosphate to 3-phosphoglycerate, exhibited inositol auxotrophy. Inositol 152-160 phosphoglycerate kinase Saccharomyces cerevisiae S288C 15-19 16330753-6 2005 The RSOR expression also increased in cells treated with various organic osmolytes, e.g., sorbitol, myoinositol, and glycerolphosphoryl-choline and H(2)O(2). Inositol 100-111 myo-inositol oxygenase Mus musculus 4-8 16410770-4 2005 We demonstrate that HCV NS4B could induce activating transcription factor (ATF6) and inositol-requiring enzyme 1 (IRE1), to favor the HCV subreplicon and HCV viral replication. Inositol 85-93 polyprotein;protein F Hepatitis C virus genotype 1 24-28 16246069-5 2005 The reduction in PS synthase in response to zinc depletion is due to a repression mechanism that involves the UAS(INO) (inositol upstream activating sequence) element in the CHO1 promoter and the negative transcription factor Opi1p. Inositol 120-128 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 174-178 16246069-6 2005 These factors are also responsible for the inositol-mediated repression of CHO1. Inositol 43-51 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 75-79 16174787-1 2005 Sodium/myo-inositol cotransporter-1 (SMIT-1) is one of the transporters responsible for importing myo-inositol (MI) into the cells. Inositol 7-19 solute carrier family 5 (inositol transporters), member 3 Mus musculus 37-43 16174787-1 2005 Sodium/myo-inositol cotransporter-1 (SMIT-1) is one of the transporters responsible for importing myo-inositol (MI) into the cells. Inositol 38-40 solute carrier family 5 (inositol transporters), member 3 Mus musculus 0-35 16174787-6 2005 All of these peripheral nerve abnormalities were corrected by prenatal MI supplement, indicating that MI is essential for the development of peripheral nerve and that neonatal lethality of the SMIT-1 knockout mice is most likely due to abnormal development of the nerves that control breathing. Inositol 71-73 solute carrier family 5 (inositol transporters), member 3 Mus musculus 193-199 16174787-7 2005 In the adult SMIT-1 deficient mice rescued by MI supplement, MI content in their brain, kidney, skeletal muscle, liver, and sciatic nerve was greatly reduced. Inositol 46-48 solute carrier family 5 (inositol transporters), member 3 Mus musculus 13-19 16169270-9 2005 Remarkably, genes involved in inositol biosynthesis and turnover were exclusively induced at high level in the galactose-intoxicated GALT-deficient cells. Inositol 30-38 galactose-1-phosphate uridylyltransferase Homo sapiens 133-137 16091461-7 2005 The most striking finding was a dramatic increase in the concentration of myo-inositol with age in APP-PS1 mice, which was not observed in wild-type mice. Inositol 74-86 presenilin 1 Mus musculus 103-106 16081790-6 2005 SP-A triggered the increase in cytosolic Ca2+ by inducing activation of phospholipase C, which leads to the hydrolysis of membrane phospholipids, yielding inositol 1,4,5-trisphosphate and mobilizing intracellularly stored Ca2+ by inositol triphosphate-sensitive channels. Inositol 155-163 surfactant protein A1 Homo sapiens 0-4 15980062-5 2005 We examined the effects of zinc depletion on the regulation of the PIS1-encoded phosphatidylinositol synthase, the enzyme that catalyzes the formation of phosphatidylinositol from CDP-diacylglycerol and inositol. Inositol 92-100 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 67-71 15992646-3 2005 Whereas administration of EPO acutely after MI reduces infarct size and improves cardiac function, its role in the failing heart is unknown. Inositol 44-46 erythropoietin Rattus norvegicus 26-29 16041130-2 2005 IRE1- and HAC1-disruptants require high concentrations of inositol for its normal growth. Inositol 58-66 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 0-4 16041130-2 2005 IRE1- and HAC1-disruptants require high concentrations of inositol for its normal growth. Inositol 58-66 transcription factor HAC1 Saccharomyces cerevisiae S288C 10-14 16041130-5 2005 However, the growth defect of the hac1-alg10 double disrupted was partially, but significantly, suppressed by the addition of inositol to the medium. Inositol 126-134 transcription factor HAC1 Saccharomyces cerevisiae S288C 34-38 16041130-5 2005 However, the growth defect of the hac1-alg10 double disrupted was partially, but significantly, suppressed by the addition of inositol to the medium. Inositol 126-134 dolichyl-P-Glc:Glc(2)Man(9)GlcNAc(2)-PP-dolichol alpha-1,2- glucosyltransferase Saccharomyces cerevisiae S288C 39-44 16237980-6 2005 Choosing of the MRS sequences was related with particular interest in metabolites of short time echo: myoinositol and lipids. Inositol 102-113 MROS Homo sapiens 16-19 16000869-6 2005 Taken together, these results suggest that SHIP1 may function as an adaptor protein which can potentiate EGF-induced PLC-gamma1 activation without regards to its inositol 5"-phosphatase activity. Inositol 162-170 inositol polyphosphate-5-phosphatase D Homo sapiens 43-48 16126965-11 2005 In contrast, the antibodies HVA2 and HLC9 (which also showed somatic hypermutations in the CDR3 region) presented polyreactivity to several phospholipids-cardiolipin, phosphatidyl-serine, -ethanolamine, -inositol, -choline, and sphingomyelin-but not to beta2-GPI. Inositol 204-212 CDR3 Homo sapiens 91-95 15918884-8 2005 Characterization of the lpa3 mutant provides direct evidence for the role of myo-inositol and MIK in phytic acid biosynthesis in developing seeds. Inositol 77-89 inositol 3-kinase Zea mays 24-28 15918884-9 2005 Recombinant maize MIK phosphorylates myo-inositol to produce multiple myo-inositol monophosphates, Ins1/3P, Ins4/6P and possibly Ins5P. Inositol 37-49 inositol 3-kinase Zea mays 18-21 15778219-1 2005 myo-Inositol oxygenase (MIOX) catalyzes the oxidative cleavage of myo-inositol (MI) to give d-glucuronic acid, a committed step in MI catabolism. Inositol 66-78 myo-inositol oxygenase Homo sapiens 4-22 15778219-1 2005 myo-Inositol oxygenase (MIOX) catalyzes the oxidative cleavage of myo-inositol (MI) to give d-glucuronic acid, a committed step in MI catabolism. Inositol 66-78 myo-inositol oxygenase Homo sapiens 24-28 15819625-1 2005 Regulated expression of structural genes involved in yeast phospholipid biosynthesis is mediated by inositol/choline-responsive element (ICRE) upstream motifs, bound by the heterodimeric activator complex Ino2 + Ino4. Inositol 100-108 Ino2p Saccharomyces cerevisiae S288C 205-209 15819625-1 2005 Regulated expression of structural genes involved in yeast phospholipid biosynthesis is mediated by inositol/choline-responsive element (ICRE) upstream motifs, bound by the heterodimeric activator complex Ino2 + Ino4. Inositol 100-108 Ino4p Saccharomyces cerevisiae S288C 212-216 15819625-2 2005 Gene repression occurs in the presence of sufficient inositol and choline, requiring an intact Opi1 repressor which binds to Ino2. Inositol 53-61 Ino2p Saccharomyces cerevisiae S288C 125-129 15716495-2 2005 Full activation of INO1 transcription occurs in the absence of inositol and requires the Snf1 protein kinase in addition to other signaling molecules and transcription factors. Inositol 63-71 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 19-23 15716495-4 2005 A mutation in SIT4 was uncovered as a suppressor of the inositol auxotrophy of snf1Delta strains. Inositol 56-64 type 2A-related serine/threonine-protein phosphatase SIT4 Saccharomyces cerevisiae S288C 14-18 15634688-3 2005 The ino1 mutant displayed wild-type growth rates and steady-state levels of PI, PIM, and LAM when grown in the presence of 1 mM inositol. Inositol 128-136 inositol-3-phosphate synthase 1 Homo sapiens 4-8 15634688-4 2005 The non-dividing ino1 mutant was highly resistant to inositol starvation, reflecting the slow turnover of inositol lipids in this stage. Inositol 53-61 inositol-3-phosphate synthase 1 Homo sapiens 17-21 15634688-5 2005 In contrast, dilution of growing or stationary-phase ino1 mutant in inositol-free medium resulted in the rapid depletion of PI and apolar PIMs. Inositol 68-76 inositol-3-phosphate synthase 1 Homo sapiens 53-57 15634688-7 2005 Metabolic labeling experiments confirmed that the large pools of PI and apolar PIMs were used to sustain polar PIM and LAM biosynthesis during inositol limitation. Inositol 143-151 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 79-82 15797548-3 2005 Genes coding for the neuropeptide hormone pituitary adenylate cyclase activating polypeptide (PACAP) and the enzyme that processes PACAP"s precursor to the mature form, peptidylglycine alpha-amidating monooxygenase, were upregulated by inositol depletion. Inositol 236-244 adenylate cyclase activating polypeptide 1 Rattus norvegicus 21-100 15797548-3 2005 Genes coding for the neuropeptide hormone pituitary adenylate cyclase activating polypeptide (PACAP) and the enzyme that processes PACAP"s precursor to the mature form, peptidylglycine alpha-amidating monooxygenase, were upregulated by inositol depletion. Inositol 236-244 adenylate cyclase activating polypeptide 1 Rattus norvegicus 94-99 15797548-4 2005 Previous work has shown that PACAP can increase tyrosine hydroxylase (TH) activity and dopamine release, and we found that the gene for GTP cyclohydrolase, which effectively regulates TH through synthesis of tetrahydrobiopterin, was also upregulated by inositol depletion. Inositol 253-261 adenylate cyclase activating polypeptide 1 Rattus norvegicus 29-34 15611057-0 2005 Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast. Inositol 29-37 Ino2p Saccharomyces cerevisiae S288C 77-82 15611057-0 2005 Genome-wide analysis reveals inositol, not choline, as the major effector of Ino2p-Ino4p and unfolded protein response target gene expression in yeast. Inositol 29-37 Ino4p Saccharomyces cerevisiae S288C 83-88 15758165-7 2005 Expression of a membrane-targeted inositol 5-phosphatase domain of synaptojanin 1 eliminated PI(4,5)P2 from the membrane and abolished secretion. Inositol 34-42 synaptojanin 1 Bos taurus 67-81 15701974-10 2005 Prior ablation of Cdc20, addition of methyl-ubiquitin, or addition of nondestructible Delta90 cyclin B rescues the MI-MII transition in Emi1-inhibited oocytes. Inositol 115-117 F-box protein 5 L homeolog Xenopus laevis 136-140 15755922-3 2005 Most of the phospholipid biosynthetic genes are regulated in response to inositol and choline via a regulatory circuit that includes the Ino2p:Ino4p activator complex and the Opi1p repressor. Inositol 73-81 Ino2p Saccharomyces cerevisiae S288C 137-142 15755922-3 2005 Most of the phospholipid biosynthetic genes are regulated in response to inositol and choline via a regulatory circuit that includes the Ino2p:Ino4p activator complex and the Opi1p repressor. Inositol 73-81 Ino4p Saccharomyces cerevisiae S288C 143-148 15755922-3 2005 Most of the phospholipid biosynthetic genes are regulated in response to inositol and choline via a regulatory circuit that includes the Ino2p:Ino4p activator complex and the Opi1p repressor. Inositol 73-81 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 175-180 15613375-2 2005 Although their transport stoichiometries have not been directly determined, significant cooperativities in the Na+ activation of SMIT1 and SMIT2 suggest that more than one Na+ ion drives the transport of each myo-inositol. Inositol 209-221 solute carrier family 5 member 3 Homo sapiens 129-134 15613375-2 2005 Although their transport stoichiometries have not been directly determined, significant cooperativities in the Na+ activation of SMIT1 and SMIT2 suggest that more than one Na+ ion drives the transport of each myo-inositol. Inositol 209-221 solute carrier family 5 member 11 Homo sapiens 139-144 15611094-0 2005 The phosphatidylglycerol/cardiolipin biosynthetic pathway is required for the activation of inositol phosphosphingolipid phospholipase C, Isc1p, during growth of Saccharomyces cerevisiae. Inositol 92-100 inositol phosphosphingolipid phospholipase Saccharomyces cerevisiae S288C 138-143 15677503-7 2005 Cytokine-induced ER Ca(2+) depletion was paralleled by an NO-dependent induction of CHOP protein and activation of diverse components of the ER stress response, including activation of inositol-requiring ER-to-nucleus signal kinase 1alpha (IRE1alpha) and PRK (RNA-dependent protein kinase)-like ER kinase (PERK)/activating transcription factor 4 (ATF4), but not ATF6. Inositol 185-193 activating transcription factor 4 Rattus norvegicus 312-345 15677503-7 2005 Cytokine-induced ER Ca(2+) depletion was paralleled by an NO-dependent induction of CHOP protein and activation of diverse components of the ER stress response, including activation of inositol-requiring ER-to-nucleus signal kinase 1alpha (IRE1alpha) and PRK (RNA-dependent protein kinase)-like ER kinase (PERK)/activating transcription factor 4 (ATF4), but not ATF6. Inositol 185-193 activating transcription factor 4 Rattus norvegicus 347-351 15677503-7 2005 Cytokine-induced ER Ca(2+) depletion was paralleled by an NO-dependent induction of CHOP protein and activation of diverse components of the ER stress response, including activation of inositol-requiring ER-to-nucleus signal kinase 1alpha (IRE1alpha) and PRK (RNA-dependent protein kinase)-like ER kinase (PERK)/activating transcription factor 4 (ATF4), but not ATF6. Inositol 185-193 activating transcription factor 6 Rattus norvegicus 362-366 15690081-3 2005 Two major proximal sensors of the UPR are inositol-requiring enzyme 1alpha (IRE1alpha), an ER transmembrane protein kinase/endoribonuclease, and ER-resident eukaryotic translation initiation factor 2alpha (eIF2alpha) kinase (PERK). Inositol 42-50 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 76-85 15780031-5 2005 Supplementation with either inositol or IP6, or their combination, starting one week prior to administration of DEN, resulted in a significant decrease in both the area and the number of placental glutathione S-transferase positive (GST-P+) foci, a preneoplastic marker for DEN-initiated hepatocarcinogenesis. Inositol 28-36 hematopoietic prostaglandin D synthase Rattus norvegicus 197-222 15780031-5 2005 Supplementation with either inositol or IP6, or their combination, starting one week prior to administration of DEN, resulted in a significant decrease in both the area and the number of placental glutathione S-transferase positive (GST-P+) foci, a preneoplastic marker for DEN-initiated hepatocarcinogenesis. Inositol 28-36 hematopoietic prostaglandin D synthase Rattus norvegicus 233-236 15780031-6 2005 The administration of inositol and/or IP6 in drinking water caused marked enhancement in the glutathione S-transferase (GST) activity. Inositol 22-30 hematopoietic prostaglandin D synthase Rattus norvegicus 93-118 15780031-6 2005 The administration of inositol and/or IP6 in drinking water caused marked enhancement in the glutathione S-transferase (GST) activity. Inositol 22-30 hematopoietic prostaglandin D synthase Rattus norvegicus 120-123 15780031-8 2005 Based on these findings, it is likely that the chemopreventive effects of inositol and/or IP6 on rat hepatocarcinogenesis initiated by DEN and promoted by PH are associated with induction of GST activity and suppression of lipid peroxidation. Inositol 74-82 hematopoietic prostaglandin D synthase Rattus norvegicus 191-194 15606695-5 2005 The potential impact of GPR40 mutations on [(3)H]-myo-inositol turnover was estimated in COS-7 cells after stimulation with various concentrations of 5,8,11-eicosatriynoic acid. Inositol 49-62 free fatty acid receptor 1 Homo sapiens 24-29 15576064-11 2004 As hypothesized, inositol reduction resulted from decreased MIP synthase activity: .21-.28 mmol/LVPA reduced the activity by 50%. Inositol 17-25 inositol-3-phosphate synthase 1 Rattus norvegicus 60-72 15576064-15 2004 CONCLUSIONS: The rate-limiting step of inositol biosynthesis, catalyzed by MIP synthase, is inhibited by VPA; inositol depletion is a first event shown to be common to lithium and VPA. Inositol 39-47 inositol-3-phosphate synthase 1 Rattus norvegicus 75-87 15576064-15 2004 CONCLUSIONS: The rate-limiting step of inositol biosynthesis, catalyzed by MIP synthase, is inhibited by VPA; inositol depletion is a first event shown to be common to lithium and VPA. Inositol 110-118 inositol-3-phosphate synthase 1 Rattus norvegicus 75-87 15504367-1 2004 myo-Inositol oxygenase (MIOX) is a non-heme iron enzyme, which catalyzes the conversion of myo-inositol to d-glucuronic acid, the first committed step in myo-inositol catabolism. Inositol 91-103 myo-inositol oxygenase Homo sapiens 4-22 15504367-1 2004 myo-Inositol oxygenase (MIOX) is a non-heme iron enzyme, which catalyzes the conversion of myo-inositol to d-glucuronic acid, the first committed step in myo-inositol catabolism. Inositol 91-103 myo-inositol oxygenase Homo sapiens 24-28 15504367-1 2004 myo-Inositol oxygenase (MIOX) is a non-heme iron enzyme, which catalyzes the conversion of myo-inositol to d-glucuronic acid, the first committed step in myo-inositol catabolism. Inositol 154-166 myo-inositol oxygenase Homo sapiens 4-22 15504367-1 2004 myo-Inositol oxygenase (MIOX) is a non-heme iron enzyme, which catalyzes the conversion of myo-inositol to d-glucuronic acid, the first committed step in myo-inositol catabolism. Inositol 154-166 myo-inositol oxygenase Homo sapiens 24-28 15560781-3 2004 The INO1 gene is deregulated (derepressed when inositol is present) under the conditions of increased phosphatidylcholine (PtdCho) turnover, as occurs in the sec14Delta cki1Delta strain (SEC14 encodes the major yeast phosphatidylinositol transfer protein; CKI1 encodes choline kinase of the cytidine diphosphate choline pathway of PtdCho biosynthesis). Inositol 47-55 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 15322018-8 2004 Although the activity of phosphatidylinositol dimannoside was little influenced by palmitoylation of mannose at C-6, a further palmitoylation at inositol C-3 diminished the induction levels of IL-6 and IL-12. Inositol 37-45 interleukin 6 Mus musculus 193-197 15352223-4 2004 Principal component analysis of ex vivo data showed that decreased levels of N-acetylaspartate (NAA), gamma-aminobutyric acid (GABA), glutamine, and glutamate as well as increased levels of inositols characterized the CLN1 spectra. Inositol 190-199 palmitoyl-protein thioesterase 1 Homo sapiens 218-222 15352223-6 2004 In concordance with the ex vivo data, the in vivo spectra of late-stage patients with CLN1 (n = 3) revealed a dramatic decrease of NAA and a proportional increase of myo-inositol and lipids compared with control subjects. Inositol 166-178 palmitoyl-protein thioesterase 1 Homo sapiens 86-90 15353567-7 2004 Expression of the unlinked genes, FAS1 and FAS2, is in part constitutive and in part subject to repression by the phospholipid precursors inositol and choline. Inositol 138-146 tetrafunctional fatty acid synthase subunit FAS1 Saccharomyces cerevisiae S288C 34-38 15353567-7 2004 Expression of the unlinked genes, FAS1 and FAS2, is in part constitutive and in part subject to repression by the phospholipid precursors inositol and choline. Inositol 138-146 trifunctional fatty acid synthase subunit FAS2 Saccharomyces cerevisiae S288C 43-47 15201274-0 2004 Regulation of the yeast EKI1-encoded ethanolamine kinase by inositol and choline. Inositol 60-68 bifunctional choline kinase/ethanolamine kinase EKI1 Saccharomyces cerevisiae S288C 24-28 15201274-1 2004 Regulation of the EKI1-encoded ethanolamine kinase by inositol and choline was examined in Saccharomyces cerevisiae. Inositol 54-62 bifunctional choline kinase/ethanolamine kinase EKI1 Saccharomyces cerevisiae S288C 18-22 15201274-3 2004 The addition of inositol to the growth medium resulted in a dose-dependent decrease in EKI1 expression. Inositol 16-24 bifunctional choline kinase/ethanolamine kinase EKI1 Saccharomyces cerevisiae S288C 87-91 15201274-6 2004 Moreover, mutational analysis showed that the UAS(INO) element in the EKI1 promoter was required for the inositol-mediated regulation. Inositol 105-113 bifunctional choline kinase/ethanolamine kinase EKI1 Saccharomyces cerevisiae S288C 70-74 15201274-7 2004 The regulation of EKI1 expression by inositol and choline was confirmed by corresponding changes in ethanolamine kinase mRNA, protein, and activity levels. Inositol 37-45 bifunctional choline kinase/ethanolamine kinase EKI1 Saccharomyces cerevisiae S288C 18-22 15157672-3 2004 We now demonstrate that transfection of macrophages with a double-stranded RNA homologous in sequence to the Grp78 gene markedly decreased induction of inositol 1,4,5-trisphosphate (IP3) and subsequent IP3-dependent elevation of [Ca2+]i induced by alpha2M*. Inositol 152-160 heat shock protein family A (Hsp70) member 5 Homo sapiens 109-114 15157672-3 2004 We now demonstrate that transfection of macrophages with a double-stranded RNA homologous in sequence to the Grp78 gene markedly decreased induction of inositol 1,4,5-trisphosphate (IP3) and subsequent IP3-dependent elevation of [Ca2+]i induced by alpha2M*. Inositol 152-160 alpha-2-macroglobulin Homo sapiens 248-256 15181167-6 2004 The affinity for myo-inositol of MDCK cells transfected with SMIT2 is slightly lower (K(m)= 334 microm) than that found in voltage-clamped Xenopus laevis oocytes expressing SMIT2 (K(m)= 120 microm). Inositol 17-29 sodium/myo-inositol cotransporter 2 Oryctolagus cuniculus 61-66 15181167-6 2004 The affinity for myo-inositol of MDCK cells transfected with SMIT2 is slightly lower (K(m)= 334 microm) than that found in voltage-clamped Xenopus laevis oocytes expressing SMIT2 (K(m)= 120 microm). Inositol 17-29 solute carrier family 5 member 3 S homeolog Xenopus laevis 173-178 15306025-3 2004 We have shown previously that Pgs1p enzyme activity is decreased within minutes after supplementation with inositol, but PGS1 expression is unaltered. Inositol 107-115 phosphatidylglycerophosphate synthase 1 Homo sapiens 30-35 15306025-5 2004 In this report, we show that, in response to inositol, the decrease in CL content and Pgs1p enzyme activity are associated with increased phosphorylation of Pgs1p, but not with degradation or mislocalization of the protein. Inositol 45-53 phosphatidylglycerophosphate synthase 1 Homo sapiens 86-91 15306025-5 2004 In this report, we show that, in response to inositol, the decrease in CL content and Pgs1p enzyme activity are associated with increased phosphorylation of Pgs1p, but not with degradation or mislocalization of the protein. Inositol 45-53 phosphatidylglycerophosphate synthase 1 Homo sapiens 157-162 15223307-8 2004 treatment with heparin, an IP(3) receptor antagonist, prevented the increase of pain threshold induced by the investigated compound, analgesia that was restored by co-administration of D-myo-inositol. Inositol 185-199 inositol 1,4,5-triphosphate receptor 3 Mus musculus 27-41 15356329-4 2004 MdSOT3- and MdSOT5-dependent sorbitol uptake was strongly inhibited by xylitol and myo-inositol, but not or only weakly by mannitol and dulcitol. Inositol 83-95 putative polyol transporter 1 Malus domestica 0-6 15356329-4 2004 MdSOT3- and MdSOT5-dependent sorbitol uptake was strongly inhibited by xylitol and myo-inositol, but not or only weakly by mannitol and dulcitol. Inositol 83-95 polyol transporter 5-like Malus domestica 12-18 15145930-2 2004 We report that phosphate limitation and inositol limitation affect GIT1 expression and Git1p transport activity via distinct mechanisms that involve multiple transcription factors. Inositol 40-48 Git1p Saccharomyces cerevisiae S288C 67-71 15145930-2 2004 We report that phosphate limitation and inositol limitation affect GIT1 expression and Git1p transport activity via distinct mechanisms that involve multiple transcription factors. Inositol 40-48 Git1p Saccharomyces cerevisiae S288C 87-92 15145930-3 2004 GIT1 transcript levels and Git1p activity are greater in cells starved for phosphate, with or without inositol limitation, than in cells only limited for inositol. Inositol 102-110 Git1p Saccharomyces cerevisiae S288C 0-4 15145930-3 2004 GIT1 transcript levels and Git1p activity are greater in cells starved for phosphate, with or without inositol limitation, than in cells only limited for inositol. Inositol 102-110 Git1p Saccharomyces cerevisiae S288C 27-32 15145930-3 2004 GIT1 transcript levels and Git1p activity are greater in cells starved for phosphate, with or without inositol limitation, than in cells only limited for inositol. Inositol 154-162 Git1p Saccharomyces cerevisiae S288C 0-4 15145930-6 2004 In contrast, Ino2p and Ino4p are required for full GIT1 expression when inositol is limiting, with or without phosphate limitation, but not when only phosphate is limiting. Inositol 72-80 Ino2p Saccharomyces cerevisiae S288C 13-18 15145930-6 2004 In contrast, Ino2p and Ino4p are required for full GIT1 expression when inositol is limiting, with or without phosphate limitation, but not when only phosphate is limiting. Inositol 72-80 Ino4p Saccharomyces cerevisiae S288C 23-28 15145930-6 2004 In contrast, Ino2p and Ino4p are required for full GIT1 expression when inositol is limiting, with or without phosphate limitation, but not when only phosphate is limiting. Inositol 72-80 Git1p Saccharomyces cerevisiae S288C 51-55 15192221-4 2004 After the addition of the lipid precursor inositol, this phosphatidic acid was rapidly consumed, releasing Opi1p from the endoplasmic reticulum and allowing its nuclear translocation and repression of target genes. Inositol 42-50 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 107-112 15259906-3 2004 We hypothesized that CSF MCP-1 levels would correlate inversely to neuronal metabolites [including N-acetyl compounds, glutamate+glutamine, as assessed by principal component analyses (PCA)] and positively to glial metabolites (including myo-inositol and choline compounds). Inositol 238-250 C-C motif chemokine ligand 2 Homo sapiens 25-30 15214506-3 2004 The current study aimed to investigate the possible modulatory role of mI versus fluoxetine or imipramine pretreatments on serotonin-2A receptor (5HT2A-R) and muscarinic acetylcholine receptor (mAChR) function and binding in in vitro systems. Inositol 71-73 5-hydroxytryptamine receptor 2A Homo sapiens 123-144 15165231-1 2004 The INO2 gene of Saccharomyces cerevisiae is required for derepression of the phospholipid biosynthetic genes in response to inositol depletion. Inositol 125-133 Ino2p Saccharomyces cerevisiae S288C 4-8 15165231-2 2004 Conversely, the OPI1 gene is required for repression in response to inositol supplementation. Inositol 68-76 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 16-20 15172003-11 2004 Significantly lower myo-inositol concentrations were observed in mothers with SLC5A11 CC-genotype, mean (SD) 14.2 (2.6)micromol/L compared to SLC5A11 TT-genotype, 17.0 (3.4)micromol/L, P <0.05 . Inositol 20-32 solute carrier family 5 member 11 Homo sapiens 78-85 15172003-11 2004 Significantly lower myo-inositol concentrations were observed in mothers with SLC5A11 CC-genotype, mean (SD) 14.2 (2.6)micromol/L compared to SLC5A11 TT-genotype, 17.0 (3.4)micromol/L, P <0.05 . Inositol 20-32 solute carrier family 5 member 11 Homo sapiens 142-149 15172003-15 2004 Moreover, maternal SLC5A11 544C > T polymorphism contributes to the serum myo-inositol concentration. Inositol 74-86 solute carrier family 5 member 11 Homo sapiens 19-26 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 112-120 inositol-3-phosphate synthase 1 Homo sapiens 64-76 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 112-120 inositol-3-phosphate synthase 1 Homo sapiens 88-93 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 157-165 inositol-3-phosphate synthase 1 Homo sapiens 64-76 15024000-5 2004 Expression of the protein in the yeast ino1Delta mutant lacking MIP synthase (ino1Delta/hINO1) complemented the inositol auxotrophy of the mutant and led to inositol excretion. Inositol 157-165 inositol-3-phosphate synthase 1 Homo sapiens 88-93 15028711-7 2004 This regulation was mediated through the UAS(INO) element and by the transcription factors Ino2p, Ino4p, and Opi1p that are responsible for the inositol-mediated regulation of UAS(INO)-containing genes involved in phospholipid synthesis. Inositol 144-152 Ino2p Saccharomyces cerevisiae S288C 91-96 15028711-7 2004 This regulation was mediated through the UAS(INO) element and by the transcription factors Ino2p, Ino4p, and Opi1p that are responsible for the inositol-mediated regulation of UAS(INO)-containing genes involved in phospholipid synthesis. Inositol 144-152 Ino4p Saccharomyces cerevisiae S288C 98-103 15028711-7 2004 This regulation was mediated through the UAS(INO) element and by the transcription factors Ino2p, Ino4p, and Opi1p that are responsible for the inositol-mediated regulation of UAS(INO)-containing genes involved in phospholipid synthesis. Inositol 144-152 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 109-114 15287594-6 2004 Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease. Inositol 41-49 complement C2 Homo sapiens 97-105 15287594-6 2004 Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease. Inositol 41-49 complement C5 Homo sapiens 110-113 15287594-6 2004 Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease. Inositol 41-49 complement C3 Homo sapiens 102-105 15287594-6 2004 Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease. Inositol 133-145 complement C2 Homo sapiens 97-105 15287594-6 2004 Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease. Inositol 133-145 complement C5 Homo sapiens 110-113 15287594-6 2004 Competition studies with eight different inositol isomers revealed that proton bonds between the C-2, C-3 and C-5 hydroxyl groups of myo-inositol and the transporter protein played a critical role for substrate recognition, and the C-3 hydroxyl oxygen appears to act as an electron donor to form an H-bond with a positive charge of the MIT permease. Inositol 133-145 complement C3 Homo sapiens 102-105 15087394-4 2004 Of 24 compounds tested, five PIAs with modifications at two sites on the inositol ring inhibited Akt with IC(50)s < 5 micro M. Molecular modeling identified putative interactions of PIAs with the phosphoinositide-binding site in the PH domain of Akt, and growth factor-induced translocation of Akt to the plasma membrane was inhibited by PIA administration. Inositol 73-81 AKT serine/threonine kinase 1 Homo sapiens 97-100 15087394-4 2004 Of 24 compounds tested, five PIAs with modifications at two sites on the inositol ring inhibited Akt with IC(50)s < 5 micro M. Molecular modeling identified putative interactions of PIAs with the phosphoinositide-binding site in the PH domain of Akt, and growth factor-induced translocation of Akt to the plasma membrane was inhibited by PIA administration. Inositol 73-81 AKT serine/threonine kinase 1 Homo sapiens 249-252 15087394-4 2004 Of 24 compounds tested, five PIAs with modifications at two sites on the inositol ring inhibited Akt with IC(50)s < 5 micro M. Molecular modeling identified putative interactions of PIAs with the phosphoinositide-binding site in the PH domain of Akt, and growth factor-induced translocation of Akt to the plasma membrane was inhibited by PIA administration. Inositol 73-81 AKT serine/threonine kinase 1 Homo sapiens 249-252 14734546-0 2004 Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. Inositol 0-8 post-GPI attachment to proteins inositol deacylase 1 Homo sapiens 96-101 14734546-0 2004 Inositol deacylation of glycosylphosphatidylinositol-anchored proteins is mediated by mammalian PGAP1 and yeast Bst1p. Inositol 0-8 Bst1p Saccharomyces cerevisiae S288C 112-117 14729908-3 2004 Recently, IRAG (inositol 1,4,5-trisphophate receptor-associated cGMP kinase substrate) has been characterized as a novel target molecule of cGMP-dependent protein kinase (cGKI) mediating NO-/cGMP-dependent inhibition of inositol 1,4,5-trisphosphate (InsP(3))-dependent calcium release in transfected COS cells. Inositol 16-24 inositol 1,4,5-triphosphate receptor associated 1 Homo sapiens 10-14 14699160-0 2004 Activation and localization of inositol phosphosphingolipid phospholipase C, Isc1p, to the mitochondria during growth of Saccharomyces cerevisiae. Inositol 31-39 inositol phosphosphingolipid phospholipase Saccharomyces cerevisiae S288C 77-82 14613899-2 2004 Two enzymes involved in myo-inositol synthesis: myo-inositol-1-phosphate synthase (ISYNA1) and myo-inositol monophosphatase-1 (IMPA1), are known to have high activity in the testes. Inositol 24-36 inositol-3-phosphate synthase 1 Rattus norvegicus 48-81 14613899-2 2004 Two enzymes involved in myo-inositol synthesis: myo-inositol-1-phosphate synthase (ISYNA1) and myo-inositol monophosphatase-1 (IMPA1), are known to have high activity in the testes. Inositol 24-36 inositol-3-phosphate synthase 1 Rattus norvegicus 83-89 14613899-2 2004 Two enzymes involved in myo-inositol synthesis: myo-inositol-1-phosphate synthase (ISYNA1) and myo-inositol monophosphatase-1 (IMPA1), are known to have high activity in the testes. Inositol 24-36 inositol monophosphatase 1 Rattus norvegicus 95-125 14613899-2 2004 Two enzymes involved in myo-inositol synthesis: myo-inositol-1-phosphate synthase (ISYNA1) and myo-inositol monophosphatase-1 (IMPA1), are known to have high activity in the testes. Inositol 24-36 inositol monophosphatase 1 Rattus norvegicus 127-132 14613899-4 2004 IMPA1 then hydrolyzes the phosphate group to produce myo-inositol. Inositol 53-65 inositol monophosphatase 1 Rattus norvegicus 0-5 14760007-9 2004 Major epididymal secretions could serve as osmolytes in murine spermatozoa for volume regulation in response to physiological osmotic challenge in the normal fertile mice; the reduced sperm content of inositol and glutamate in the c-ros knockout mice might reflect maturational abnormalities in volume regulation. Inositol 201-209 Ros1 proto-oncogene Mus musculus 231-236 14749729-3 2004 Here, we demonstrate that, in brain and PC12 cells, the recently identified H(+)/myo-inositol symporter HMIT is present in intracellular vesicles that are distinct from synaptic and dense-core vesicles. Inositol 81-93 solute carrier family 2 member 13 Rattus norvegicus 104-108 14749729-5 2004 HMIT cell surface expression takes place preferentially in regions of nerve growth and at varicosities and leads to increased myo-inositol uptake. Inositol 126-138 solute carrier family 2 member 13 Rattus norvegicus 0-4 14749729-7 2004 HMIT is thus expressed in a vesicular compartment involved in activity-dependent regulation of myo-inositol uptake in neurons. Inositol 95-107 solute carrier family 2 member 13 Rattus norvegicus 0-4 14729261-8 2004 Further, inositol, the product of IMP catalysis, and Li+, an inhibitor of IMP catalysis, decreased expression of the LeIMP-2 promoter as measured by a decrease in beta-glucuronidase activity after treatment. Inositol 9-17 inositol monophosphatase 2 Solanum lycopersicum 117-124 12750891-4 2004 Despite their sequence similarity and the presence of class-specific signature sequences, these transporters carry various hexoses and HMIT is a H(+)/ myo-inositol co-transporter. Inositol 151-163 solute carrier family 2 (facilitated glucose transporter), member 13 Mus musculus 135-139 12750891-8 2004 Much remains to be learned about the transport functions of the recently discovered isoforms (GLUT6-13 and HMIT) and their physiological role in the metabolism of glucose, myo-inositol and perhaps other substrates. Inositol 172-184 solute carrier family 2 (facilitated glucose transporter), member 6 Mus musculus 94-99 12750891-8 2004 Much remains to be learned about the transport functions of the recently discovered isoforms (GLUT6-13 and HMIT) and their physiological role in the metabolism of glucose, myo-inositol and perhaps other substrates. Inositol 172-184 solute carrier family 2 (facilitated glucose transporter), member 13 Mus musculus 107-111 14659671-5 2004 The hydroxyalkyl groups were introduced at the C-3 of myo-inositol using the corresponding benzyl protected hydroxy alkyl bromide via the cis-2,3-O-dibutylstannylene acetal. Inositol 54-66 complement C3 Homo sapiens 47-50 14613966-8 2004 Application of peptide inhibitors to neurulation-stage embryos revealed an absolute dependence on the activity of PKCbetaI and gamma for prevention of NTDs by inositol, and partial dependence on PKCzeta, whereas other PKCs (alpha, betaII delta, and epsilon) were dispensable. Inositol 159-167 protein kinase C, gamma Mus musculus 114-132 14613966-12 2004 Our findings reveal an essential role of specific PKC isoforms in mediating the prevention of mouse NTDs by inositol. Inositol 108-116 protein kinase C, alpha Mus musculus 50-53 16233644-2 2004 The transcriptional heterodimeric complex composed of the gene products of INO2 and INO4 binds to a conserved cis-acting upstream activating sequence designated as the inositol-choline responsive element (ICRE), and activates the expression of these genes. Inositol 168-176 Ino2p Saccharomyces cerevisiae S288C 75-79 16233644-2 2004 The transcriptional heterodimeric complex composed of the gene products of INO2 and INO4 binds to a conserved cis-acting upstream activating sequence designated as the inositol-choline responsive element (ICRE), and activates the expression of these genes. Inositol 168-176 Ino4p Saccharomyces cerevisiae S288C 84-88 16233644-3 2004 In the presence of inositol and choline, the expression of these genes is downregulated and a functional OPI1 gene product is necessary for this repression. Inositol 19-27 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 105-109 16233644-4 2004 The promoter region of OPI1 contains one copy of ICRE, and here we analyzed the involvement of ICRE in the inositol-choline-mediated gene regulation of OPI1. Inositol 107-115 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 23-27 16233644-4 2004 The promoter region of OPI1 contains one copy of ICRE, and here we analyzed the involvement of ICRE in the inositol-choline-mediated gene regulation of OPI1. Inositol 107-115 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 152-156 16233674-10 2004 In the final stage of sake mash, the disruption of the ino1 gene responsible for inositol synthesis, resulted in a decrease in cell density. Inositol 81-89 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 55-59 16233674-11 2004 Furthermore, the ino1 disruptant, which was not capable of increasing the cellular inositol level in the final stage, exhibited a significantly higher methylene blue-staining ratio than the parental strain. Inositol 83-91 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 17-21 14715857-0 2004 Metformin therapy increases insulin-stimulated release of D-chiro-inositol-containing inositolphosphoglycan mediator in women with polycystic ovary syndrome. Inositol 58-74 insulin Homo sapiens 28-35 14715857-1 2004 Some actions of insulin are mediated by putative inositolphosphoglycan mediators, and a deficiency in D-chiro-inositol-containing inositolphosphoglycan (DCI-IPG) may contribute to insulin resistance in women with polycystic ovary syndrome (PCOS). Inositol 102-118 insulin Homo sapiens 180-187 15056985-8 2004 Hypertonicity by mannitol or myoinositol also increased ROSIT mRNA expression. Inositol 29-40 solute carrier family 6 member 18 Rattus norvegicus 56-61 15559765-2 2004 D-3-Deoxy-phosphatidyl-myo-inositols that cannot be phosphorylated on the 3-position of the myo-inositol group are inhibitors of the Akt PH domain. Inositol 23-35 thymoma viral proto-oncogene 1 Mus musculus 133-136 14527956-2 2003 Yeast SAC1 mutants display a wide array of phenotypes including inositol auxotrophy, cold sensitivity, secretory defects, disturbed ATP transport into the ER, or suppression of actin gene mutations. Inositol 64-72 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 6-10 14692775-1 2003 A GPI of sperm CD52 was synthesized by a highly convergent procedure, representing the first chemical synthesis of a complex GPI having an acylated inositol. Inositol 148-156 CD52 molecule Homo sapiens 15-19 14532265-4 2003 Myoinositol alone or myoinositol, betaine, and taurine given sequentially increased the processing of core-glycosylated, endoplasmic reticulum-arrested Delta F508 CFTR into the fully glycosylated form of CFTR in IB3 cells or NIH 3T3 cells stably expressing Delta F508 CFTR. Inositol 0-11 CF transmembrane conductance regulator Homo sapiens 163-167 14532265-4 2003 Myoinositol alone or myoinositol, betaine, and taurine given sequentially increased the processing of core-glycosylated, endoplasmic reticulum-arrested Delta F508 CFTR into the fully glycosylated form of CFTR in IB3 cells or NIH 3T3 cells stably expressing Delta F508 CFTR. Inositol 0-11 CF transmembrane conductance regulator Homo sapiens 204-208 14532265-4 2003 Myoinositol alone or myoinositol, betaine, and taurine given sequentially increased the processing of core-glycosylated, endoplasmic reticulum-arrested Delta F508 CFTR into the fully glycosylated form of CFTR in IB3 cells or NIH 3T3 cells stably expressing Delta F508 CFTR. Inositol 0-11 CF transmembrane conductance regulator Homo sapiens 204-208 14532265-4 2003 Myoinositol alone or myoinositol, betaine, and taurine given sequentially increased the processing of core-glycosylated, endoplasmic reticulum-arrested Delta F508 CFTR into the fully glycosylated form of CFTR in IB3 cells or NIH 3T3 cells stably expressing Delta F508 CFTR. Inositol 21-32 CF transmembrane conductance regulator Homo sapiens 163-167 14532265-4 2003 Myoinositol alone or myoinositol, betaine, and taurine given sequentially increased the processing of core-glycosylated, endoplasmic reticulum-arrested Delta F508 CFTR into the fully glycosylated form of CFTR in IB3 cells or NIH 3T3 cells stably expressing Delta F508 CFTR. Inositol 21-32 CF transmembrane conductance regulator Homo sapiens 204-208 14532265-4 2003 Myoinositol alone or myoinositol, betaine, and taurine given sequentially increased the processing of core-glycosylated, endoplasmic reticulum-arrested Delta F508 CFTR into the fully glycosylated form of CFTR in IB3 cells or NIH 3T3 cells stably expressing Delta F508 CFTR. Inositol 21-32 CF transmembrane conductance regulator Homo sapiens 204-208 14532265-7 2003 In vitro studies of purified NBD1 stability and aggregation showed that myoinositol stabilized both the Delta F508 and wild type CFTR and inhibited Delta F508 misfolding. Inositol 72-83 CF transmembrane conductance regulator Homo sapiens 129-133 14642843-1 2003 D-chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Inositol 0-16 insulin Homo sapiens 57-64 14642843-1 2003 D-chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Inositol 0-16 insulin Homo sapiens 141-148 14642843-1 2003 D-chiro-Inositol (DCI) enhances reproductive function in insulin-resistant women with polycystic ovarian disease and enhances the effects of insulin in the periphery, suggesting that this compound may act in part by sensitizing the hypothalamus to effects of insulin. Inositol 0-16 insulin Homo sapiens 141-148 14640572-1 2003 The antihyperglycemic effects of chemically synthesized d-chiro-inositol (d-CI), a component of an insulin mediator, have been demonstrated in rats. Inositol 56-72 enoyl-CoA delta isomerase 1 Rattus norvegicus 74-78 14683460-6 2003 A family of phosphatidyl inositol phosphatases have been identified that counter-regulate PI3K activity by hydrolyzing PIP(3) to phosphatidyl inositol bisphosphate at either the 3" or 5" position of the inositol ring. Inositol 25-33 prolactin induced protein Homo sapiens 119-122 14690594-1 2003 Myotubularin-related proteins are a large subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylate D3-phosphorylated inositol lipids. Inositol 131-139 myotubularin 1 Homo sapiens 0-12 14608380-6 2003 The NTDs in Grhl3-/- embryos are also folate resistant, but unlike those in ct/ct mice, they are resistant to inositol. Inositol 110-118 grainyhead like transcription factor 3 Mus musculus 12-17 14608380-7 2003 These findings suggest that residual Grhl3 expression in ct/ct mice may be required for inositol rescue of folate-resistant NTDs. Inositol 88-96 grainyhead like transcription factor 3 Mus musculus 37-42 14642771-4 2003 Expression of the DPP1 gene, which encodes DGPP phosphatase, is induced by zinc depletion, by inositol supplementation, and when cells enter the stationary phase. Inositol 94-102 bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase Saccharomyces cerevisiae S288C 18-22 14567985-3 2003 The Minpp protein dephosphorylates highly phosphorylated inositol signaling molecules InsP(5) and InsP(6). Inositol 57-65 inositol hexaphosphate kinase 1 Mus musculus 98-105 14587102-2 2003 Opi1 is a negative regulator responsible for repression of ICRE-dependent genes in the presence of an excess of inositol and choline. Inositol 112-120 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 0-4 14563413-7 2003 These results, together with the determination of the apparent affinity constants of AtPIS1 for myo-inositol and CDP-diacylglycerol, allow us to discuss some of the constraints of PtdIns synthesis in plants in terms of specificity, which will depend on the subcellular localization of the protein. Inositol 96-108 phosphatidylinositol synthase 1 Arabidopsis thaliana 85-91 12890676-2 2003 PIS1 gene expression is unusual because it is uncoupled from the other phospholipid biosynthetic genes, which are regulated in response to inositol and choline. Inositol 139-147 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 0-4 14614649-11 2003 Elevated myo-inositol may not only indicate osmolar changes in glial cells but also glial cell alteration due to amyloid or amylin deposition with formation of neurofibrillary tangles, especially as these changes are found in all of these diseases and no correlation to osmolar deterioration exists. Inositol 9-21 islet amyloid polypeptide Homo sapiens 124-130 12941308-1 2003 myo-Inositol 1-phosphate synthase (EC 5.5.1.4) (IPS) is a key enzyme in myo-inositol biosynthesis pathway. Inositol 72-84 inositol-3-phosphate synthase 1 Homo sapiens 48-51 12821656-5 2003 Growth in the presence of the inositol-depleting drug valproate led to an increase in phosphatidylglycerophosphate synthase activity unaccompanied by increased PGS1 mRNA. Inositol 30-38 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 160-164 12857747-1 2003 Phosphatase and tensin homologue deleted on chromosome 10 (PTEN) is a tumor suppressor that is lost in many human tumors and encodes a phosphatidylinositol phosphate phosphatase specific for the 3-position of the inositol ring. Inositol 147-155 phosphatase and tensin homolog Homo sapiens 59-63 12857747-8 2003 Hence, the interaction between PI(4,5)P2 and PTEN requires specific, ionic interactions with the phosphate groups on the inositol ring as well as hydrophobic interactions with the fatty acid chains, likely mimicking the physiological interactions that PTEN has with the polar surface head groups and the hydrophobic core of phospholipid membranes. Inositol 121-129 phosphatase and tensin homolog Homo sapiens 45-49 12937339-5 2003 Li+, a GSK3 beta inhibitor, led to E-cadherin induction in an inositol-independent manner. Inositol 62-70 cadherin 1 Homo sapiens 35-45 12950923-6 2003 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol 70-78 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 100-104 12950923-6 2003 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol 70-78 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 106-110 12950923-6 2003 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol 70-78 Ino2p Saccharomyces cerevisiae S288C 115-119 12950923-6 2003 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol 134-142 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 100-104 12950923-6 2003 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol 134-142 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 106-110 12950923-6 2003 Surprisingly, expression of genes that are usually derepressed during inositol depletion, including INO1, CHO1 and INO2 (that contain inositol-responsive UASINO sequences) decreased several fold during the first hour, after which expression began to increase. Inositol 134-142 Ino2p Saccharomyces cerevisiae S288C 115-119 12943000-11 2003 All three mood stabilizers suppress inositol signaling, results further supported by studies on the enzyme prolyl oligopeptidase (PO) and the sodium myo-inositol transporter (SMIT). Inositol 36-44 prolyl endopeptidase Homo sapiens 107-128 12943000-11 2003 All three mood stabilizers suppress inositol signaling, results further supported by studies on the enzyme prolyl oligopeptidase (PO) and the sodium myo-inositol transporter (SMIT). Inositol 36-44 prolyl endopeptidase Homo sapiens 130-132 12912892-0 2003 Inositol and phosphate regulate GIT1 transcription and glycerophosphoinositol incorporation in Saccharomyces cerevisiae. Inositol 0-8 Git1p Saccharomyces cerevisiae S288C 32-36 12912892-4 2003 The transport of exogenous glycerophosphoinositol through Git1p is sufficiently robust to support the growth of an inositol auxotroph (ino1Delta). Inositol 41-49 Git1p Saccharomyces cerevisiae S288C 58-63 12912892-8 2003 Deletion of PHO86 in an ino1Delta strain resulted in faster growth when either phosphatidylinositol or glycerophosphoinositol was supplied as the sole inositol source. Inositol 91-99 Pho86p Saccharomyces cerevisiae S288C 12-17 12912892-10 2003 All strains accumulated the most GIT1 transcript when incubated in media limited for inositol and phosphate in combination. Inositol 85-93 Git1p Saccharomyces cerevisiae S288C 33-37 12912892-13 2003 These results indicate that the transport of glycerophosphoinositol by Git1p is regulated by factors affecting both inositol and phosphate availabilities and suggest a regulatory connection between phosphate metabolism and phospholipid metabolism. Inositol 59-67 Git1p Saccharomyces cerevisiae S288C 71-76 12877981-1 2003 In the de novo synthesis of inositol, the conversion of D-glucose-6-phosphate to L-myo-inositol-1-phosphate (MIP) is catalyzed by MIP synthase. Inositol 28-36 myo-inositol 1-phosphate synthase A1 Mus musculus 130-142 12877981-9 2003 In yeast, when inositol is limiting, the heterodimeric transcriptional activator Ino2p/Ino4p derepresses expression of INO1 by binding to the upstream activation sequence UAS(INO). Inositol 15-23 Ino2p Saccharomyces cerevisiae S288C 81-86 12877981-9 2003 In yeast, when inositol is limiting, the heterodimeric transcriptional activator Ino2p/Ino4p derepresses expression of INO1 by binding to the upstream activation sequence UAS(INO). Inositol 15-23 Ino4p Saccharomyces cerevisiae S288C 87-92 12877981-9 2003 In yeast, when inositol is limiting, the heterodimeric transcriptional activator Ino2p/Ino4p derepresses expression of INO1 by binding to the upstream activation sequence UAS(INO). Inositol 15-23 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 119-123 12877981-11 2003 The fact that lithium treatment upregulates both MIP synthase and IMPA1 mRNA levels in mouse hippocampus may reflect a compensatory response of both genes to inositol depletion. Inositol 158-166 myo-inositol 1-phosphate synthase A1 Mus musculus 49-61 12877981-11 2003 The fact that lithium treatment upregulates both MIP synthase and IMPA1 mRNA levels in mouse hippocampus may reflect a compensatory response of both genes to inositol depletion. Inositol 158-166 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 66-71 12714589-0 2003 GWT1 gene is required for inositol acylation of glycosylphosphatidylinositol anchors in yeast. Inositol 26-34 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 0-4 12714589-8 2003 The incorporation of inositol into GPI-anchored proteins was reduced in gwt1 mutant, indicating involvement of GWT1 in GPI biosynthesis. Inositol 21-29 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 72-76 12714589-8 2003 The incorporation of inositol into GPI-anchored proteins was reduced in gwt1 mutant, indicating involvement of GWT1 in GPI biosynthesis. Inositol 21-29 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 111-115 12714589-10 2003 The synthetic activity of GlcN-(acyl)PI from GlcN-PI was defective in these cells, whereas Deltagwt1 cells harboring GWT1 gene restored the activity, indicating that GWT1 is required for acylation of inositol during the GPI synthetic pathway. Inositol 200-208 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 166-170 12714589-11 2003 We further cloned GWT1 homologues in other yeasts, Cryptococcus neoformans and Schizosaccharomyces pombe, and confirmed that the specificity of acyl-CoA in inositol acylation, as reported in studies of endogenous membranes (Franzot, S. P., and Doering, T. L. (1999) Biochem. Inositol 156-164 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 18-22 12716899-8 2003 Phosphoinositide binding specificity, determined using a protein-lipid overlay procedure, suggests that alpha-actinin interacts with phosphates on the 4th and 5th position of the inositol head group. Inositol 179-187 actinin alpha 1 Homo sapiens 104-117 12763599-6 2003 Pretreatment with the inositol 1,4,5-trisphosphate (IP(3)) receptor antagonist xestospongin C (10 microM) for 20 min inhibited markedly the somatostatin-induced response. Inositol 22-30 inositol 1,4,5-triphosphate receptor 3 Mus musculus 52-67 12668681-8 2003 The beta-galactosidase activity driven by an INO1-CYC-lacZ reporter gene in opi1Delta mutant cells expressing the S31A and S251A mutant Opi1p proteins was elevated 42 and 35%, respectively, in the absence of inositol and 55 and 52%, respectively, in the presence of inositol when compared with cells expressing wild type Opi1p. Inositol 208-216 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 45-49 12668681-8 2003 The beta-galactosidase activity driven by an INO1-CYC-lacZ reporter gene in opi1Delta mutant cells expressing the S31A and S251A mutant Opi1p proteins was elevated 42 and 35%, respectively, in the absence of inositol and 55 and 52%, respectively, in the presence of inositol when compared with cells expressing wild type Opi1p. Inositol 208-216 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 136-141 12668681-8 2003 The beta-galactosidase activity driven by an INO1-CYC-lacZ reporter gene in opi1Delta mutant cells expressing the S31A and S251A mutant Opi1p proteins was elevated 42 and 35%, respectively, in the absence of inositol and 55 and 52%, respectively, in the presence of inositol when compared with cells expressing wild type Opi1p. Inositol 266-274 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 45-49 12668681-8 2003 The beta-galactosidase activity driven by an INO1-CYC-lacZ reporter gene in opi1Delta mutant cells expressing the S31A and S251A mutant Opi1p proteins was elevated 42 and 35%, respectively, in the absence of inositol and 55 and 52%, respectively, in the presence of inositol when compared with cells expressing wild type Opi1p. Inositol 266-274 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 136-141 12637551-4 2003 Pretreatment of MMICs with a COX2-specific inhibitor (SC58236, 10 micromol/liter) dramatically reduced osmolyte accumulation (by 79 +/- 9, 57 +/- 12, and 96 +/- 10% for inositol, sorbitol, and betaine respectively, p < 0.05). Inositol 169-177 cytochrome c oxidase II, mitochondrial Mus musculus 29-33 12753200-1 2003 In the yeast Saccharomyces cerevisiae, genes involved in phospholipid biosynthesis are activated by ICRE (inositol/choline-responsive element) up-stream motifs and the corresponding heterodimeric binding factor, Ino2 + Ino4. Inositol 106-114 Ino2p Saccharomyces cerevisiae S288C 212-216 12753200-1 2003 In the yeast Saccharomyces cerevisiae, genes involved in phospholipid biosynthesis are activated by ICRE (inositol/choline-responsive element) up-stream motifs and the corresponding heterodimeric binding factor, Ino2 + Ino4. Inositol 106-114 Ino4p Saccharomyces cerevisiae S288C 219-223 12713536-2 2003 SAC1p has been implicated in multiple cellular functions: actin cytoskeleton organization, secretory functions, inositol metabolism, ATP transport, and multiple-drug sensitivity. Inositol 112-120 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 0-5 12713536-4 2003 We demonstrated that the three AtSAC1 proteins are functional homologs of the yeast SAC1p because they can rescue the cold-sensitive and inositol auxotroph yeast sac1-null mutant strain. Inositol 137-145 Phosphoinositide phosphatase family protein Arabidopsis thaliana 31-37 12713536-4 2003 We demonstrated that the three AtSAC1 proteins are functional homologs of the yeast SAC1p because they can rescue the cold-sensitive and inositol auxotroph yeast sac1-null mutant strain. Inositol 137-145 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 84-89 12713536-4 2003 We demonstrated that the three AtSAC1 proteins are functional homologs of the yeast SAC1p because they can rescue the cold-sensitive and inositol auxotroph yeast sac1-null mutant strain. Inositol 137-145 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 162-166 12566438-4 2003 In this study, biochemical characterization of the mouse nSMase2 was carried out using the overexpressed protein in yeast cells in which the inositol phosphosphingolipid phospholipase C (Isc1p) was deleted. Inositol 141-149 sphingomyelin phosphodiesterase 3, neutral Mus musculus 57-64 12566438-4 2003 In this study, biochemical characterization of the mouse nSMase2 was carried out using the overexpressed protein in yeast cells in which the inositol phosphosphingolipid phospholipase C (Isc1p) was deleted. Inositol 141-149 inositol phosphosphingolipid phospholipase Saccharomyces cerevisiae S288C 187-192 12682335-1 2003 The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. Inositol 55-67 MROS Homo sapiens 4-7 12682335-1 2003 The MRS brain metabolite ratio N-acetylaspartate (NAA)/myo-inositol (mI) is reported to be decreased in AD. Inositol 69-71 MROS Homo sapiens 4-7 12670397-1 2003 The initiating events associated with T activation in response to stimulation of the T cell antigen receptor (TCR) and costimulatory receptors, such as CD28, are intimately associated with the enzymatically catalyzed addition of phosphate not only to key tyrosine, threonine and serine residues in proteins but also to the D3 position of the myo-inositol ring of phosphatidylinositol (PtdIns). Inositol 342-354 CD28 molecule Homo sapiens 152-156 12761300-1 2003 In the yeast Saccharomyces cerevisiae, the expression of phospholipid biosynthetic genes, including the INO1 gene (encoding inositol-1-phosphate synthase), is coordinately regulated by a cis-acting transcriptional element, UAS(INO) (inositol-sensitive upstream activating sequence). Inositol 124-132 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 104-108 12761300-3 2003 SCS2 encodes a type II membrane protein and its deletion leads to inositol auxotrophy at temperatures above 34 degrees C. We found that the expression of the INO1 gene was reduced in the scs2Delta strain even when the cells were cultured under derepressing conditions for INO1 expression. Inositol 66-74 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 0-4 12761300-3 2003 SCS2 encodes a type II membrane protein and its deletion leads to inositol auxotrophy at temperatures above 34 degrees C. We found that the expression of the INO1 gene was reduced in the scs2Delta strain even when the cells were cultured under derepressing conditions for INO1 expression. Inositol 66-74 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 158-162 12700283-3 2003 We report a novel strategy to inhibit Akt activation based on the use of D-3-deoxy-phosphatidyl-myo-inositols (DPIs) that cannot be phosphorylated on the 3-position of the myo-inositol ring. Inositol 96-108 thymoma viral proto-oncogene 1 Mus musculus 38-41 12822887-8 2003 The determination of the structure and position of the PH domain with respect to the known X-ray structure of the kinase active site could be useful in the rational design of potent and selective inhibitors of PDK1 and PKB by "linking" the free energies of binding of substrate (ATP) analogs with analogs of the inositol polar head group of the phospholipid second messenger. Inositol 312-320 pyruvate dehydrogenase kinase 1 Homo sapiens 210-214 12822887-8 2003 The determination of the structure and position of the PH domain with respect to the known X-ray structure of the kinase active site could be useful in the rational design of potent and selective inhibitors of PDK1 and PKB by "linking" the free energies of binding of substrate (ATP) analogs with analogs of the inositol polar head group of the phospholipid second messenger. Inositol 312-320 protein tyrosine kinase 2 beta Homo sapiens 219-222 12593845-3 2003 Overexpression of the IMP2 gene has the opposite effects and these results suggest that IMPase activity is limiting for the inositol cycle. Inositol 124-132 endopeptidase catalytic subunit Saccharomyces cerevisiae S288C 22-26 12605865-3 2003 As expected, the aberrant labeling of ATP is markedly reduced with the use of 3H-myo-inositol labeled at L-C1 rather than at C2, reflecting that the 3H at L-C1 disappears in the first step of the myo-inositol catabolism: the oxidative conversion to D-glucuronate. Inositol 81-93 microtubule-associated protein 1B Mus musculus 105-109 12605865-3 2003 As expected, the aberrant labeling of ATP is markedly reduced with the use of 3H-myo-inositol labeled at L-C1 rather than at C2, reflecting that the 3H at L-C1 disappears in the first step of the myo-inositol catabolism: the oxidative conversion to D-glucuronate. Inositol 81-93 microtubule-associated protein 1B Mus musculus 155-159 12667599-4 2003 Dietary myo-inositol significantly depressed the rises in hepatic concentrations of total lipids, triglyceride and cholesterol and the activities of ME and G6PD due to DDT feeding regardless of dietary carbohydrate quality. Inositol 8-20 glucose-6-phosphate dehydrogenase Rattus norvegicus 156-160 12667599-5 2003 Dietary starch supplemented with myo-inositol potentiated the enhancements in hepatic activities of Phase II drug-metabolizing enzymes such as glutathione S-transferase and 4NP-UDPGT due to DDT feeding. Inositol 33-45 UDP glucuronosyltransferase family 1 member A6 Rattus norvegicus 173-182 12627883-2 2003 Na+/myo-inositol is one of the major organic osmolytes in the brain and Na+/myo-inositol cotransporter (SMIT) regulates extracellular Na+/myo-inositol content. Inositol 4-16 solute carrier family 5 member 3 Rattus norvegicus 104-108 12627883-2 2003 Na+/myo-inositol is one of the major organic osmolytes in the brain and Na+/myo-inositol cotransporter (SMIT) regulates extracellular Na+/myo-inositol content. Inositol 76-88 solute carrier family 5 member 3 Rattus norvegicus 104-108 12551726-7 2003 The increased enzyme activity may alter critical neurochemical processes involving either free myo-inositol, the precursor of inositol based signaling system or other metabolic pathways, since IMPase 1 also utilizes selective sugar phosphates, such as galactose-1-phosphate, as substrates. Inositol 95-107 inositol monophosphatase 1 Rattus norvegicus 193-201 12551726-7 2003 The increased enzyme activity may alter critical neurochemical processes involving either free myo-inositol, the precursor of inositol based signaling system or other metabolic pathways, since IMPase 1 also utilizes selective sugar phosphates, such as galactose-1-phosphate, as substrates. Inositol 99-107 inositol monophosphatase 1 Rattus norvegicus 193-201 12586875-9 2003 The mutants also accumulate myo-inositol and inositol phosphates as in the lpa2 mutant. Inositol 28-40 inositol-tetrakisphosphate 1-kinase 1 Zea mays 75-79 12497619-3 2003 One is PIK4CA, a member of the phosphatidylinositol 4-kinase family that phosphorylates PtdIns at the D4 position of the inositol ring as part of the PtdIns-4,5-P(2) synthetic pathway. Inositol 43-51 phosphatidylinositol 4-kinase alpha Homo sapiens 7-13 12917943-0 2003 Insulin-sensitising drugs (metformin, troglitazone, rosiglitazone, pioglitazone, D-chiro-inositol) for polycystic ovary syndrome. Inositol 81-97 insulin Homo sapiens 0-7 14583919-3 2003 OBJECTIVES: To assess the effectiveness/safety of supplementary inositol in preterm infants with RDS in reducing adverse neonatal outcomes. Inositol 64-72 peripherin 2 Homo sapiens 97-100 12777063-0 2003 Localization of GPI-80, a beta2-integrin-associated glycosylphosphatidyl-inositol anchored protein, on strongly CD14-positive human monocytes. Inositol 73-81 vanin 2 Homo sapiens 16-22 16233524-9 2003 Under inositol-free culture conditions, GFP-fused Itr1p appeared and was localized to the plasma membrane. Inositol 6-14 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 50-55 16233524-10 2003 When the cells were cultured in the presence of inositol, GFP-fused Itr1p gradually disappeared from the plasma membrane, the fluorescence being redistributed within the cell. Inositol 48-56 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 68-73 16233438-6 2003 A disruptant of the OPI1 gene, an inositol/choline-mediated negative regulatory gene, produced higher amounts of MCFA than the control strain both in the static culture and in sake mash when a sufficient amount of inositol was supplemented. Inositol 34-42 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 20-24 16233438-9 2003 Co-overexpression of FAS1 and FAS2 resulted in a maximal stimulation of MCFA formation and substantially abolished the inhibitory effect of inositol on MCFA formation. Inositol 140-148 tetrafunctional fatty acid synthase subunit FAS1 Saccharomyces cerevisiae S288C 21-25 16233438-9 2003 Co-overexpression of FAS1 and FAS2 resulted in a maximal stimulation of MCFA formation and substantially abolished the inhibitory effect of inositol on MCFA formation. Inositol 140-148 trifunctional fatty acid synthase subunit FAS2 Saccharomyces cerevisiae S288C 30-34 16233438-10 2003 These results suggest that the repression of FAS1 gene expression by inositol results in the decrease in MCFA formation. Inositol 69-77 tetrafunctional fatty acid synthase subunit FAS1 Saccharomyces cerevisiae S288C 45-49 16233438-11 2003 Therefore, it is presumed that the removal of inositol by polishing the rice used in sake brewing, increases the production of ethyl esters of MCFA, since high-level production of MCFA is achieved by the derepression of FAS1 transcription. Inositol 46-54 tetrafunctional fatty acid synthase subunit FAS1 Saccharomyces cerevisiae S288C 220-224 12529653-4 2003 The results of an in vitro inositol 5"-phosphatase assay revealed that the mutation reduced catalytic activity of SHIP. Inositol 27-35 inositol polyphosphate-5-phosphatase D Homo sapiens 114-118 12519189-1 2003 Lithium and valproate, two structurally different anti-bipolar drugs, cause decreased intracellular inositol in the yeast Saccharomyces cerevisiae and an in-crease in expression of a structural (INO1) and a regulatory (INO2) gene for phospholipid synthesis that responds to inositol depletion (Vaden, D., Ding, D., Peterson, B., and Greenberg, M.L., 2001, J Biol Chem 276: 15466-15471). Inositol 274-282 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 195-199 14510501-4 2003 Quantitative RT-PCR analysis showed that only the SAM2 gene was subject to the inositol-choline regulation, consistent with the fact that only the SAM2 gene has two octamer sequences in its upstream region. Inositol 79-87 methionine adenosyltransferase SAM2 Saccharomyces cerevisiae S288C 50-54 12622701-1 2003 The uptake of myo-inositol by mouse oocytes and preimplantation embryos of a crossbred (DBA x C57BL/6) and a purebred outbred strain (MF1) was measured using [2-(3)H]myo-inositol. Inositol 14-26 forkhead box C1 Mus musculus 134-137 12467885-3 2002 In the present study, we examined the tissue distribution of PRIP-2, its expression in rat brain at the mRNA level, and the characteristics of its binding to inositol compounds, protein phosphatase 1, and gamma-amino butyric acid receptor associated protein. Inositol 158-166 nuclear receptor coactivator 6 Rattus norvegicus 61-65 15251831-1 2002 OBJECTIVE: To determine whether the administration of D-chiro-inositol, a putative insulin-sensitizing drug, would affect the concentration of circulating insulin, the levels of serum androgens, and the frequency of ovulation in lean women with the polycystic ovary syndrome. Inositol 54-70 insulin Homo sapiens 83-90 15251831-1 2002 OBJECTIVE: To determine whether the administration of D-chiro-inositol, a putative insulin-sensitizing drug, would affect the concentration of circulating insulin, the levels of serum androgens, and the frequency of ovulation in lean women with the polycystic ovary syndrome. Inositol 54-70 insulin Homo sapiens 155-162 15251831-5 2002 RESULTS: In the 10 women given D-chiro-inositol, the mean (+/- standard error) area under the plasma insulin curve after oral administration of glucose decreased significantly from 8,343 +/- 1,149 mU/mL per min to 5,335 +/- 1,792 mU/mL per min in comparison with no significant change in the placebo group (P = 0.03 for difference between groups). Inositol 31-47 insulin Homo sapiens 101-108 15251831-9 2002 CONCLUSION: We conclude that, in lean women with the polycystic ovary syndrome, D-chiro-inositol reduces circulating insulin, decreases serum androgens, and ameliorates some of the metabolic abnormalities (increased blood pressure and hypertriglyceridemia) of syndrome X. Inositol 80-96 insulin Homo sapiens 117-124 12368808-4 2002 In taste cells, Trpm5 was coexpressed with taste-signaling molecules such as alpha-gustducin, Ggamma13, phospholipase C-beta2 (PLC-beta2) and inositol 1,4,5-trisphosphate receptor type III (IP3R3). Inositol 142-150 transient receptor potential cation channel subfamily M member 5 Homo sapiens 16-21 12414302-2 2002 We hypothesized that the probable glial markers myo-inositol [MI] and choline compounds [CHO] would correlate with cognitive function, CD4 count, and viral loads, but not with serum lipids. Inositol 48-60 CD4 molecule Homo sapiens 135-138 12401206-4 2002 Modeling predicts that upon association of PI-TPalpha with the membrane the inositol moiety of bound PI is accessible from the medium. Inositol 76-84 phosphatidylinositol transfer protein alpha Homo sapiens 43-53 12399377-3 2002 Elevated dosage of SCS2, previously implicated as a regulator of both inositol biosynthesis and telomeric silencing, suppressed the dominant-negative effect of a SIR2-143 mutation. Inositol 70-78 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 19-23 12133831-3 2002 The expressed protein, which we have named SMIT2, cotransports myo-inositol with a K(m) of 120 microm and displays a current-voltage relationship similar to that seen with SMIT (now called SMIT1). Inositol 63-75 solute carrier family 5 member 3 S homeolog Xenopus laevis 43-48 12133831-3 2002 The expressed protein, which we have named SMIT2, cotransports myo-inositol with a K(m) of 120 microm and displays a current-voltage relationship similar to that seen with SMIT (now called SMIT1). Inositol 63-75 solute carrier family 5 member 3 S homeolog Xenopus laevis 43-47 12133831-3 2002 The expressed protein, which we have named SMIT2, cotransports myo-inositol with a K(m) of 120 microm and displays a current-voltage relationship similar to that seen with SMIT (now called SMIT1). Inositol 63-75 solute carrier family 5 member 3 S homeolog Xenopus laevis 189-194 12133831-8 2002 In addition, SMIT2 (but not SMIT1) transports d-chiro-inositol. Inositol 46-62 solute carrier family 5 member 3 S homeolog Xenopus laevis 13-18 12133831-9 2002 Based on previous publications, the tissue distribution of SMIT2 is different from that of SMIT1, and the existence of this second cotransporter may explain much of the heterogeneity that has been reported for inositol transport. Inositol 210-218 solute carrier family 5 member 3 S homeolog Xenopus laevis 59-64 12193412-7 2002 The hTrp3 variant introduces sequence between exons 8 and 9 that would insert 16 amino acids in the C-terminal region of the protein upstream of the calmodulin and inositol 1,4,5-triphosphate receptor interaction domain. Inositol 164-172 transient receptor potential cation channel subfamily C member 3 Homo sapiens 4-9 12217398-4 2002 When coaggregated with FcepsilonRI, the FcgammaRIIB ITIM is tyrosyl-phosphorylated by the src family protein tyrosine kinase lyn, and recruits the SH2 domain-containing inositol 5-phosphatase SHIP that accounts for inhibition of cell activation. Inositol 169-177 Fc epsilon receptor Ia Homo sapiens 23-34 12217398-4 2002 When coaggregated with FcepsilonRI, the FcgammaRIIB ITIM is tyrosyl-phosphorylated by the src family protein tyrosine kinase lyn, and recruits the SH2 domain-containing inositol 5-phosphatase SHIP that accounts for inhibition of cell activation. Inositol 169-177 Fc gamma receptor IIb Homo sapiens 40-51 12217398-4 2002 When coaggregated with FcepsilonRI, the FcgammaRIIB ITIM is tyrosyl-phosphorylated by the src family protein tyrosine kinase lyn, and recruits the SH2 domain-containing inositol 5-phosphatase SHIP that accounts for inhibition of cell activation. Inositol 169-177 LYN proto-oncogene, Src family tyrosine kinase Homo sapiens 125-128 12217398-4 2002 When coaggregated with FcepsilonRI, the FcgammaRIIB ITIM is tyrosyl-phosphorylated by the src family protein tyrosine kinase lyn, and recruits the SH2 domain-containing inositol 5-phosphatase SHIP that accounts for inhibition of cell activation. Inositol 169-177 inositol polyphosphate-5-phosphatase D Homo sapiens 192-196 12149650-1 2002 Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3" kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Inositol 91-99 phosphatase and tensin homolog Mus musculus 14-18 12149650-1 2002 Expression of PTEN tumor suppressor gene has been known to dephosphorylate the phosphatidylinositol 3" kinase (PI3K) products on the 3 prime inositol ring, resulting in reduced Akt activation. Inositol 91-99 thymoma viral proto-oncogene 1 Mus musculus 177-180 12113831-1 2002 An inner core of the GPI anchor of sperm CD52 antigens was synthesized by a highly convergent process using specially modified inositol, glucosamine and phospholipid as key building blocks. Inositol 127-135 glucose-6-phosphate isomerase Homo sapiens 21-24 12113831-1 2002 An inner core of the GPI anchor of sperm CD52 antigens was synthesized by a highly convergent process using specially modified inositol, glucosamine and phospholipid as key building blocks. Inositol 127-135 CD52 molecule Homo sapiens 41-45 12113831-2 2002 This paper also presents a new and efficient procedure to prepare 1,2,6-differentiated derivatives of inositol for GPI syntheses. Inositol 102-110 glucose-6-phosphate isomerase Homo sapiens 115-118 12153579-9 2002 The activity of PtdEtn-PLD was reduced by 30-40% upon addition to the medium of inositol (75 micro m) in either wild-type yeast or spo14Delta mutants and this effect was seen regardless of the presence of choline, suggesting that transcription of the PtdEtn-PLD gene is down-regulated by inositol. Inositol 80-88 phospholipase D Saccharomyces cerevisiae S288C 23-26 12153579-9 2002 The activity of PtdEtn-PLD was reduced by 30-40% upon addition to the medium of inositol (75 micro m) in either wild-type yeast or spo14Delta mutants and this effect was seen regardless of the presence of choline, suggesting that transcription of the PtdEtn-PLD gene is down-regulated by inositol. Inositol 80-88 phospholipase D Saccharomyces cerevisiae S288C 258-261 12153579-9 2002 The activity of PtdEtn-PLD was reduced by 30-40% upon addition to the medium of inositol (75 micro m) in either wild-type yeast or spo14Delta mutants and this effect was seen regardless of the presence of choline, suggesting that transcription of the PtdEtn-PLD gene is down-regulated by inositol. Inositol 288-296 phospholipase D Saccharomyces cerevisiae S288C 23-26 11955285-1 2002 Calmodulin (CaM) is a ubiquitous protein that plays a critical role in regulating cellular functions by altering the activity of a large number of proteins, including the d-myo-inositol 1,4,5-trisphosphate (IP3) receptor (IP3R). Inositol 171-185 inositol 1,4,5-trisphosphate receptor type 1 Homo sapiens 207-220 12131928-7 2002 The basal secretion of PRL was significatively reduced by LiCl, and restored by the concomitant addition of both LiCl and myo-inositol. Inositol 122-134 prolactin Rattus norvegicus 23-26 12458657-1 2002 Two classes of inositol phosphoglycans have been implicated as second messengers of insulin, one that activates pyruvate dehydrogenase and contains D-chiroinositol, and one that inhibits cyclic AMP-dependent protein kinase and contains myoinositol. Inositol 236-247 insulin Homo sapiens 84-91 11916969-6 2002 Mannose, glucose, maltose, and inositol, at millimolar concentrations, competed for human SP-D binding to the bacterial membrane. Inositol 31-39 surfactant protein D Homo sapiens 90-94 12015604-8 2002 Moreover, the development of Dictyostelium is sensitive to lithium and to valproic acid, but resistance to both is conferred by deletion of the gene that codes for prolyl oligopeptidase, which also regulates inositol metabolism. Inositol 208-216 prolyl endopeptidase Homo sapiens 164-185 11934692-7 2002 We found that phosphoinositides containing phosphate at both positions 4 and 5 of the inositol head group have the highest efficacy in activating ROMK1 channels. Inositol 86-94 potassium inwardly rectifying channel subfamily J member 1 Homo sapiens 146-151 11956339-5 2002 The caspase-3 activity of the cells also increased dramatically under these conditions, but remained negligibly low when betaine and myo-inositol were added to the medium. Inositol 133-145 caspase 3 Homo sapiens 4-13 11956339-7 2002 In the absence of compatible osmolytes, increased mRNA levels and corresponding activities of betaine/gamma-aminobutyric acid transporter (BGT1) and sodium/myo-inositol transporter (SMIT) induced by hypertonicity remained high after 72 h incubation, whereas they were down regulated in the presence of betaine and myo-inositol. Inositol 156-168 solute carrier family 5 member 3 Homo sapiens 182-186 11937980-10 2002 D-chiro-inositol is a mediator of insulin action and improves ovulatory cycles. Inositol 0-16 insulin Homo sapiens 34-41 11872634-3 2002 In animals fed a diet containing a mixture of myoinositol and dexamethasone, a treatment found previously to be effective in preventing the development of tobacco smoke-induced lung tumors in A/J mice, cyclin D1/2 expression was reduced to 30-40% of control levels. Inositol 46-57 cyclin D1 Mus musculus 202-213 11872634-4 2002 A similar decrease in cyclin D1/2 expression was found when animals were fed either myoinositol or dexamethasone alone. Inositol 84-95 cyclin D1 Mus musculus 22-33 11856479-2 2002 PI synthase (PIS, cytidine diphosphate (CDP)-diacylglycerol (DG): myo-inositol 3-phosphatidyltransferase, EC 2.7.8.11) acts at the last step in the de novo biosynthesis of PI by catalyzing the condensation of CDP-DG and myo-inositol. Inositol 66-78 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) Mus musculus 0-11 12479670-3 2002 It has been shown that lithium inhibits yeast inositol monophosphatase (encoded by INM1 and INM2), and both valproate and lithium reduce intracellular inositol. Inositol 46-54 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 83-87 12479670-3 2002 It has been shown that lithium inhibits yeast inositol monophosphatase (encoded by INM1 and INM2), and both valproate and lithium reduce intracellular inositol. Inositol 46-54 inositol monophosphate 1-phosphatase INM2 Saccharomyces cerevisiae S288C 92-96 12479670-8 2002 It has also been reported previously that both lithium and inositol mildly up-regulate IMPA1 (encoding mammalian inositol monophosphatase) expression in human cells. Inositol 59-67 inositol monophosphatase 1 Homo sapiens 87-92 12001182-1 2002 Inositol, a precursor of the PIP cycle that was reported to have therapeutic effects in depressive patients and to be effective in two animal models of depression, was evaluated in the forced swim test using the genetic Flinders Sensitive Line (FSL) rats model of depression. Inositol 0-8 prolactin induced protein Homo sapiens 29-32 11900279-0 2002 D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance. Inositol 0-16 insulin Homo sapiens 41-48 11900279-0 2002 D-chiro-inositol--its functional role in insulin action and its deficit in insulin resistance. Inositol 0-16 insulin Homo sapiens 75-82 11900279-1 2002 In this review we discuss the biological significance of D-chiro-inositol, originally discovered as a component of a putative mediator of intracellular insulin action, where as a putative mediator, it accelerates the dephosphorylation of glycogen synthase and pyruvate dehydrogenase, rate limiting enzymes of non-oxidative and oxidative glucose disposal. Inositol 57-73 insulin Homo sapiens 152-159 11900279-4 2002 Administration of D-chiro-inositol to diabetic rats, Rhesus monkeys and now to humans accelerated glucose disposal and sensitized insulin action. Inositol 18-34 insulin Homo sapiens 130-137 11900279-5 2002 A defect in vivo in the epimerization of myo-inositol to chiro-inositol in insulin sensitive tissues of the GK type 2 diabetic rat has been elucidated. Inositol 41-53 insulin Homo sapiens 75-82 11900279-5 2002 A defect in vivo in the epimerization of myo-inositol to chiro-inositol in insulin sensitive tissues of the GK type 2 diabetic rat has been elucidated. Inositol 57-71 insulin Homo sapiens 75-82 11900279-6 2002 Thus, administered D-chiro-inositol may act to bypass a defective normal epimerization of myo-inositol to D-chiro-inositol associated with insulin resistance and act to at least partially restore insulin sensitivity and glucose disposal. Inositol 19-35 insulin Homo sapiens 139-146 11900279-6 2002 Thus, administered D-chiro-inositol may act to bypass a defective normal epimerization of myo-inositol to D-chiro-inositol associated with insulin resistance and act to at least partially restore insulin sensitivity and glucose disposal. Inositol 19-35 insulin Homo sapiens 196-203 11900279-6 2002 Thus, administered D-chiro-inositol may act to bypass a defective normal epimerization of myo-inositol to D-chiro-inositol associated with insulin resistance and act to at least partially restore insulin sensitivity and glucose disposal. Inositol 106-122 insulin Homo sapiens 139-146 11840310-0 2002 Epi-inositol regulates expression of the yeast INO1 gene encoding inositol-1-P synthase. Inositol 0-12 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 47-51 11840310-6 2002 Epi-inositol affects regulation of expression of the INO1 gene (encoding inositol-1-P synthase), even though it cannot support growth of an inositol auxotroph (suggesting that, as in mammalian cells, it is not incorporated into phosphatidylinositol). Inositol 0-12 inositol-3-phosphate synthase 1 Homo sapiens 53-57 11840310-6 2002 Epi-inositol affects regulation of expression of the INO1 gene (encoding inositol-1-P synthase), even though it cannot support growth of an inositol auxotroph (suggesting that, as in mammalian cells, it is not incorporated into phosphatidylinositol). Inositol 4-12 inositol-3-phosphate synthase 1 Homo sapiens 53-57 11840310-7 2002 Like myo-inositol, although to a lesser extent, epi-inositol causes a significant reduction in INO1 expression, and reverses the lithium- or valproate-induced increase in INO1 expression. Inositol 5-17 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 95-99 11840310-7 2002 Like myo-inositol, although to a lesser extent, epi-inositol causes a significant reduction in INO1 expression, and reverses the lithium- or valproate-induced increase in INO1 expression. Inositol 48-60 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 95-99 11840310-7 2002 Like myo-inositol, although to a lesser extent, epi-inositol causes a significant reduction in INO1 expression, and reverses the lithium- or valproate-induced increase in INO1 expression. Inositol 48-60 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 171-175 11716759-0 2001 myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. Inositol 90-102 inositol oxygenase Sus scrofa 0-22 11716759-0 2001 myo-Inositol oxygenase: molecular cloning and expression of a unique enzyme that oxidizes myo-inositol and D-chiro-inositol. Inositol 107-123 inositol oxygenase Sus scrofa 0-22 11716759-1 2001 myo-Inositol oxygenase (MIOX) catalyses the first committed step in the only pathway of myo-inositol catabolism, which occurs predominantly in the kidney. Inositol 88-100 inositol oxygenase Sus scrofa 4-22 11716759-1 2001 myo-Inositol oxygenase (MIOX) catalyses the first committed step in the only pathway of myo-inositol catabolism, which occurs predominantly in the kidney. Inositol 88-100 inositol oxygenase Sus scrofa 24-28 11716759-8 2001 D-chiro-Inositol, a myo-inositol isomer, is a substrate for the recombinant MIOX with an estimated K(m) of 33.5 mM. Inositol 0-16 inositol oxygenase Sus scrofa 76-80 11716759-8 2001 D-chiro-Inositol, a myo-inositol isomer, is a substrate for the recombinant MIOX with an estimated K(m) of 33.5 mM. Inositol 20-32 inositol oxygenase Sus scrofa 76-80 11533064-1 2001 Phosphorylation of inositol 1,3,4-trisphosphate by inositol 1,3,4-trisphosphate 5/6-kinase is the first committed step in the formation of higher phosphorylated forms of inositol. Inositol 19-27 inositol-tetrakisphosphate 1-kinase Bos taurus 51-90 11526217-4 2001 Thus, the interactions between HIV-1 Gag protein molecules are altered by binding of inositol derivatives; this binding is apparently essential for normal HIV-1 particle assembly. Inositol 85-93 Pr55(Gag) Human immunodeficiency virus 1 37-40 11489850-10 2001 Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium. Inositol 92-100 Itc1p Saccharomyces cerevisiae S288C 37-41 11489850-10 2001 Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium. Inositol 92-100 DNA translocase Saccharomyces cerevisiae S288C 45-49 11489850-10 2001 Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium. Inositol 92-100 transcription factor HAC1 Saccharomyces cerevisiae S288C 63-67 11489850-10 2001 Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium. Inositol 188-196 Itc1p Saccharomyces cerevisiae S288C 37-41 11489850-10 2001 Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium. Inositol 188-196 DNA translocase Saccharomyces cerevisiae S288C 45-49 11489850-10 2001 Surprisingly, the deletion of either ITC1 or ISW2 in the Delta hac1 strain circumvented the inositol requirement and caused derepression of INO1 even under repression conditions, i.e., in inositol-containing medium. Inositol 188-196 transcription factor HAC1 Saccharomyces cerevisiae S288C 63-67 11507211-3 2001 ORF74 activates the inositol phosphate/phospholipase C pathway and the downstream mitogen-activated protein kinases, JNK/SAPK and p38. Inositol 20-28 ORF74 Human gammaherpesvirus 8 0-5 11507211-3 2001 ORF74 activates the inositol phosphate/phospholipase C pathway and the downstream mitogen-activated protein kinases, JNK/SAPK and p38. Inositol 20-28 mitogen-activated protein kinase 14 Homo sapiens 130-133 11486011-2 2001 To identify targets of the Snf1 kinase that modulate expression of INO1, a gene required for an early, rate-limiting step in phospholipid biosynthesis, we performed a genetic selection for suppressors of the inositol auxotrophy of snf1Delta strains. Inositol 208-216 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 67-71 11486011-7 2001 Moreover, a reduction in Acc1 activity, caused by addition of soraphen A, provision of exogenous fatty acid, or conditional expression of ACC1, suppresses the inositol auxotrophy of snf1Delta strains. Inositol 159-167 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 25-29 11486011-7 2001 Moreover, a reduction in Acc1 activity, caused by addition of soraphen A, provision of exogenous fatty acid, or conditional expression of ACC1, suppresses the inositol auxotrophy of snf1Delta strains. Inositol 159-167 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 138-142 11486011-8 2001 Together, these findings indicate that the inositol auxotrophy of snf1Delta strains arises in part from elevated Acc1 activity and that a reduction in this activity restores INO1 expression in these strains. Inositol 43-51 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 113-117 11500374-4 2001 Functional expression of HMIT in Xenopus oocytes showed that transport activity was specific for myo-inositol and related stereoisomers with a Michaelis-Menten constant of approximately 100 microM, and that transport activity was strongly stimulated by decreasing pH. Inositol 97-109 solute carrier family 2 member 13 S homeolog Xenopus laevis 25-29 11500374-9 2001 Predominant central expression of HMIT suggests that it has a key role in the control of myo-inositol brain metabolism. Inositol 89-101 solute carrier family 2 member 13 Homo sapiens 34-38 11483660-4 2001 Addition of inositol or 8-Br-cyclic GMP completely reversed these Abeta-induced changes. Inositol 12-20 amyloid beta precursor protein Rattus norvegicus 66-71 11483660-8 2001 Addition of inositol or 8-Br-cyclic GMP prevented the effect of Abeta-treatment on the neurotoxicity of glutamate. Inositol 12-20 amyloid beta precursor protein Rattus norvegicus 64-69 11488393-3 2001 We now know that PTEN is a tumor suppressor for many tumor types and is a phosphatidylinositol phosphatase specific for the 3-position of the inositol ring. Inositol 86-94 phosphatase and tensin homolog Homo sapiens 17-21 11718091-9 2001 The average percentage of CD34+ cells after CBU separation was (0.5 +/- 0.32)%. Inositol 44-47 CD34 molecule Homo sapiens 26-30 11437440-9 2001 Thus, loss of regulatory control over PKC activity during oocyte maturation disrupts the critical MI-to-MII transition, leading to a precocious exit from meiosis. Inositol 98-100 protein kinase C, delta Mus musculus 38-41 11497481-10 2001 Patients treated with another insulin sensitizer, D-chiro-inositol, have demonstrated improved insulin sensitivity, ovulatory rates, and biochemical findings. Inositol 50-66 insulin Homo sapiens 30-37 11497481-10 2001 Patients treated with another insulin sensitizer, D-chiro-inositol, have demonstrated improved insulin sensitivity, ovulatory rates, and biochemical findings. Inositol 50-66 insulin Homo sapiens 95-102 11454208-2 2001 Gene activation by an ICRE is mediated by binding of the Ino2/Ino4 transcription factor, whereas repression in the presence of high concentrations of inositol and choline (IC) requires an intact Opi1 repressor. Inositol 150-158 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 195-199 11287412-9 2001 This suggests that phosphorylation and possible PDGFbetaR-mediated sequestration of SHIP1 from its substrates (PtdIns(3,4,5)P(3) and Ins(1,3,4,5)P(4)) might alter the levels of these inositol-containing signal transduction molecules, resulting in activation of downstream effectors of cellular proliferation and/or survival. Inositol 183-191 inositol polyphosphate-5-phosphatase D Mus musculus 84-89 11434680-8 2001 In cells induced to differentiate by ATRA, CD11b expression seems more closely related to inositol uptake than to PKC activity while the expression of TF and TM show the opposite pattern, which suggests cellular events regulated at a different level within a common signal transduction pathway. Inositol 90-98 integrin subunit alpha M Homo sapiens 43-48 11331006-1 2001 Phosphatidylinositol-specific phospholipase C (PI-PLC) catalyzes the cleavage of the P-O bond in phosphatidylinositol via intramolecular nucleophilic attack of the 2-hydroxyl group of inositol on the phosphorus atom. Inositol 12-20 phospholipase C beta 1 Homo sapiens 47-53 11278575-5 2001 Concomitant treatment of RBL-2H3 cells with LY294002 or Deltap85 and 2-aminoethyl diphenylborate, a cell-permeant antagonist of D-myo-inositol 1,4,5-trisphosphate receptors, abrogates antigen-induced Ca(2+) signals, whereas either treatment alone gives rise to partial inhibition. Inositol 128-142 RB transcriptional corepressor like 2 Rattus norvegicus 25-30 11333225-4 2001 We identified SCS2 (suppressor of choline sensitivity), a gene previously isolated as a suppressor of defects in inositol synthesis. Inositol 113-121 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 14-18 11438031-3 2001 The Mia antigen has been reported to be present on red blood cells with several Miltenberger phenotypes, namely: Mi.I, Mi.II, Mi.III, Mi.IV, Mi.VI and Mi.X. Inositol 80-82 MIA SH3 domain containing Homo sapiens 4-7 11438031-3 2001 The Mia antigen has been reported to be present on red blood cells with several Miltenberger phenotypes, namely: Mi.I, Mi.II, Mi.III, Mi.IV, Mi.VI and Mi.X. Inositol 80-82 MIA SH3 domain containing Homo sapiens 4-7 11438031-3 2001 The Mia antigen has been reported to be present on red blood cells with several Miltenberger phenotypes, namely: Mi.I, Mi.II, Mi.III, Mi.IV, Mi.VI and Mi.X. Inositol 80-82 MIA SH3 domain containing Homo sapiens 4-7 11438031-3 2001 The Mia antigen has been reported to be present on red blood cells with several Miltenberger phenotypes, namely: Mi.I, Mi.II, Mi.III, Mi.IV, Mi.VI and Mi.X. Inositol 80-82 MIA SH3 domain containing Homo sapiens 4-7 11438031-3 2001 The Mia antigen has been reported to be present on red blood cells with several Miltenberger phenotypes, namely: Mi.I, Mi.II, Mi.III, Mi.IV, Mi.VI and Mi.X. Inositol 80-82 MIA SH3 domain containing Homo sapiens 4-7 11401540-0 2001 The SH2 domain containing inositol 5-phosphatase SHIP2 controls phosphatidylinositol 3,4,5-trisphosphate levels in CHO-IR cells stimulated by insulin. Inositol 26-34 insulin Cricetulus griseus 142-149 11405099-2 2001 Inositol and choline repress transcription of the INO2 gene, and its target genes. Inositol 0-8 Ino2p Saccharomyces cerevisiae S288C 50-54 11547915-0 2001 D-chiro-inositol in insulin action and insulin resistance-old-fashioned biochemistry still at work. Inositol 0-16 insulin Homo sapiens 20-27 11251853-2 2001 Complete derepression of phospholipid biosynthetic gene expression in response to inositol/choline deprivation requires both INO2 and INO4. Inositol 82-90 Ino2p Saccharomyces cerevisiae S288C 125-129 11251853-2 2001 Complete derepression of phospholipid biosynthetic gene expression in response to inositol/choline deprivation requires both INO2 and INO4. Inositol 82-90 Ino4p Saccharomyces cerevisiae S288C 134-138 11063746-2 2001 RGS2 has been shown to regulate Galpha(q)-mediated inositol lipid signaling. Inositol 51-59 LOW QUALITY PROTEIN: regulator of G-protein signaling 2 Meleagris gallopavo 0-4 11163636-6 2001 In mice, the specific 5-HT(2A)/5-HT(2C) antagonist ritanserin, but not the 5-HT(1A)/5-HT(1B)/beta adrenergic antagonist pindolol, abolished inositol"s effect in the forced swim test. Inositol 140-148 5-hydroxytryptamine (serotonin) receptor 2A Mus musculus 22-29 11156592-12 2001 We conclude that coupling of hP2Y(11) receptors to adenylyl cyclase in these cell lines is much weaker than coupling to phospholipase C, and that activation of PKC and intracellular Ca(2+) mobilization as consequences of inositol lipid hydrolysis potentiates the capacity of ATP to increase cyclic AMP accumulation in both 1321N1-hP2Y(11) and CHO-hP2Y(11) cells. Inositol 221-229 purinergic receptor P2Y11 Homo sapiens 29-37 11280715-0 2001 Relationships of plasma C-peptide and gender to the urinary excretion of inositols in older people. Inositol 73-82 insulin Homo sapiens 24-33 11280715-1 2001 PURPOSE: The urinary excretions of myo-inositol and D-chiro-inositol are elevated in diabetes, and have been suggested as possible markers or effectors of insulin action. Inositol 35-47 insulin Homo sapiens 155-162 11280715-1 2001 PURPOSE: The urinary excretions of myo-inositol and D-chiro-inositol are elevated in diabetes, and have been suggested as possible markers or effectors of insulin action. Inositol 52-68 insulin Homo sapiens 155-162 11280715-10 2001 For all subjects combined, C-peptide AUC was positively correlated with the urinary excretion of each of the measured inositols, as well as the myo-inositol:D-chiro-inositol ratio. Inositol 118-127 insulin Homo sapiens 27-36 11280715-10 2001 For all subjects combined, C-peptide AUC was positively correlated with the urinary excretion of each of the measured inositols, as well as the myo-inositol:D-chiro-inositol ratio. Inositol 144-156 insulin Homo sapiens 27-36 11280715-10 2001 For all subjects combined, C-peptide AUC was positively correlated with the urinary excretion of each of the measured inositols, as well as the myo-inositol:D-chiro-inositol ratio. Inositol 118-126 insulin Homo sapiens 27-36 11280715-11 2001 The correlations between C-peptide AUC and these inositols were strongly influenced by the co-linear relationship between C-peptide AUC and gender. Inositol 49-58 insulin Homo sapiens 25-34 11280715-11 2001 The correlations between C-peptide AUC and these inositols were strongly influenced by the co-linear relationship between C-peptide AUC and gender. Inositol 49-58 insulin Homo sapiens 122-131 11280715-12 2001 CONCLUSIONS: Collectively, these data show that older, moderately overweight, non-diabetic men and women with gender-related differences in glucose-stimulated C-peptide AUC, an indirect indicator of insulin secretion, also display differences in the urinary excretion of myo-inositol, D-chiro-inositol, L-chiro-inositol, and pinitol. Inositol 271-283 insulin Homo sapiens 159-168 11280715-12 2001 CONCLUSIONS: Collectively, these data show that older, moderately overweight, non-diabetic men and women with gender-related differences in glucose-stimulated C-peptide AUC, an indirect indicator of insulin secretion, also display differences in the urinary excretion of myo-inositol, D-chiro-inositol, L-chiro-inositol, and pinitol. Inositol 285-301 insulin Homo sapiens 159-168 11280715-12 2001 CONCLUSIONS: Collectively, these data show that older, moderately overweight, non-diabetic men and women with gender-related differences in glucose-stimulated C-peptide AUC, an indirect indicator of insulin secretion, also display differences in the urinary excretion of myo-inositol, D-chiro-inositol, L-chiro-inositol, and pinitol. Inositol 303-319 insulin Homo sapiens 159-168 11016943-0 2000 Regulation of the DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol and growth phase. Inositol 82-90 bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase Saccharomyces cerevisiae S288C 18-22 11016943-2 2000 The regulation of the Saccharomyces cerevisiae DPP1-encoded diacylglycerol pyrophosphate (DGPP) phosphatase by inositol supplementation and growth phase was examined. Inositol 111-119 bifunctional diacylglycerol diphosphate phosphatase/phosphatidate phosphatase Saccharomyces cerevisiae S288C 47-51 11023840-6 2000 Finally, the luminal portion of Ire1p (Ire=high inositol-requiring), thought to convey the sensing function of this transmembrane kinase and endoribonuclease, was shown to contain repeats similar to those in beta-propeller proteins. Inositol 48-56 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 32-37 10952930-6 2000 Myometrial cells were treated with IL-1 for 24 h. Oxytocin-stimulated inositol trisphosphate (IP(3)) production was measured in tritiated myoinositol-loaded myometrial cells. Inositol 138-149 oxytocin/neurophysin I prepropeptide Homo sapiens 50-58 10941192-3 2000 These proteins interact directly with the inositol (1,4,5)-trisphosphate receptor/ Ca2+ channel at the intragranular pH 5.5, not only changing the conformation of the inositol (1,4,5)-trisphosphate receptor/Ca2+ channel but also modulating the channel activity. Inositol 42-50 carbonic anhydrase 2 Homo sapiens 83-86 10941192-3 2000 These proteins interact directly with the inositol (1,4,5)-trisphosphate receptor/ Ca2+ channel at the intragranular pH 5.5, not only changing the conformation of the inositol (1,4,5)-trisphosphate receptor/Ca2+ channel but also modulating the channel activity. Inositol 42-50 carbonic anhydrase 2 Homo sapiens 207-210 10928995-5 2000 GPI linkage of NS1 in both transfected and infected cells was demonstrated by cleavage of NS1 from the surface by PI-specific phospholipase C and by metabolic incorporation of the GPI-specific components ethanolamine and inositol. Inositol 221-229 influenza virus NS1A binding protein Homo sapiens 15-18 10930462-2 2000 Both gene products phosphorylate PtdIns at the D-4 position of the inositol ring to generate PtdIns(4)P, which plays an essential role in yeast viability because deletion of either STT4 or PIK1 is lethal. Inositol 67-75 1-phosphatidylinositol 4-kinase STT4 Saccharomyces cerevisiae S288C 181-185 10930462-2 2000 Both gene products phosphorylate PtdIns at the D-4 position of the inositol ring to generate PtdIns(4)P, which plays an essential role in yeast viability because deletion of either STT4 or PIK1 is lethal. Inositol 67-75 1-phosphatidylinositol 4-kinase Saccharomyces cerevisiae S288C 189-193 10869284-0 2000 Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms. Inositol 124-138 gastrin Rattus norvegicus 0-7 10869284-0 2000 Gastrin inhibits cholangiocyte growth in bile duct-ligated rats by interaction with cholecystokinin-B/Gastrin receptors via D-myo-inositol 1,4,5-triphosphate-, Ca(2+)-, and protein kinase C alpha-dependent mechanisms. Inositol 124-138 gastrin Rattus norvegicus 102-109 10764800-0 2000 Inositol stereoisomers stabilize an oligomeric aggregate of Alzheimer amyloid beta peptide and inhibit abeta -induced toxicity. Inositol 0-8 amyloid beta precursor protein Rattus norvegicus 103-108 10764800-4 2000 The ability of inositol stereoisomers to interact with and stabilize small Abeta complexes was addressed. Inositol 15-23 amyloid beta precursor protein Rattus norvegicus 75-80 10764800-8 2000 We demonstrate that inositol-Abeta interactions result in a complex that is non-toxic to nerve growth factor-differentiated PC-12 cells and primary human neuronal cultures. Inositol 20-28 amyloid beta precursor protein Rattus norvegicus 29-34 10764800-9 2000 The attenuation of toxicity is the result of Abeta-inositol interaction, as inositol uptake inhibitors had no effect on neuronal survival. Inositol 51-59 amyloid beta precursor protein Homo sapiens 45-50 10764800-10 2000 The use of inositol stereoisomers allowed us to elucidate an important structure-activity relationship between Abeta and inositol. Inositol 11-19 amyloid beta precursor protein Rattus norvegicus 111-116 10764800-10 2000 The use of inositol stereoisomers allowed us to elucidate an important structure-activity relationship between Abeta and inositol. Inositol 121-129 amyloid beta precursor protein Rattus norvegicus 111-116 10764800-11 2000 Inositol stereoisomers are naturally occurring molecules that readily cross the blood-brain barrier and may represent a viable treatment for AD through the complexation of Abeta and attenuation of Abeta neurotoxic effects. Inositol 0-8 amyloid beta precursor protein Homo sapiens 172-177 10868628-4 2000 When taurine, betaine, and inositol (2 mmol/L, each) were added to the preperfusion and storage buffer, lactate dehydrogenase, aspartate amino transferase, and glutathione S-transferase leakage into the effluent perfusate during the reoxygenation period were less than half compared to controls without osmolytes and bile flow was higher. Inositol 27-35 hematopoietic prostaglandin D synthase Rattus norvegicus 160-185 11252649-2 2000 This article examines the potential relevance of an alternative mechanism for inositol depletion: inhibition of myo-inositol uptake that proceeds via the sodium/myo-inositol cotransport (SMIT). Inositol 78-86 solute carrier family 5 member 3 Homo sapiens 154-185 11252649-2 2000 This article examines the potential relevance of an alternative mechanism for inositol depletion: inhibition of myo-inositol uptake that proceeds via the sodium/myo-inositol cotransport (SMIT). Inositol 78-86 solute carrier family 5 member 3 Homo sapiens 187-191 11252649-2 2000 This article examines the potential relevance of an alternative mechanism for inositol depletion: inhibition of myo-inositol uptake that proceeds via the sodium/myo-inositol cotransport (SMIT). Inositol 112-124 solute carrier family 5 member 3 Homo sapiens 154-185 11252649-2 2000 This article examines the potential relevance of an alternative mechanism for inositol depletion: inhibition of myo-inositol uptake that proceeds via the sodium/myo-inositol cotransport (SMIT). Inositol 112-124 solute carrier family 5 member 3 Homo sapiens 187-191 10923253-19 2000 Aldose reductase inhibitors might reduce sorbitol and fructose production and normalize myo-inositol levels. Inositol 88-100 aldo-keto reductase family 1 member B Homo sapiens 0-16 10794675-0 2000 Normalization of hyperosmotic-induced inositol uptake by renal and endothelial cells is regulated by NF-kappaB. Inositol 38-46 nuclear factor kappa B subunit 1 Homo sapiens 101-110 10794675-5 2000 Inhibiting NF-kappaB activation with pyrrolidine dithiocarbamate (PD) blocks the normalization of SMIT mRNA levels and myo-inositol accumulation on removal of the cells from hyperosmotic medium. Inositol 119-131 nuclear factor kappa B subunit 1 Homo sapiens 11-20 10781542-10 2000 We further report that the INO4 steady-state transcript levels and Ino4p levels are regulated twofold in response to inositol and choline, suggesting a posttranscriptional mechanism of regulation. Inositol 117-125 Ino4p Saccharomyces cerevisiae S288C 27-31 10781542-10 2000 We further report that the INO4 steady-state transcript levels and Ino4p levels are regulated twofold in response to inositol and choline, suggesting a posttranscriptional mechanism of regulation. Inositol 117-125 Ino4p Saccharomyces cerevisiae S288C 67-72 10844654-0 2000 Expression of yeast INM1 encoding inositol monophosphatase is regulated by inositol, carbon source and growth stage and is decreased by lithium and valproate. Inositol 34-42 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 20-24 10844654-8 2000 Unlike all other phospholipid biosynthetic enzyme-encoding genes studied, which contain the UASINO regulatory element, INM1 expression is increased in the presence of inositol. Inositol 167-175 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 119-123 10844654-10 2000 Both lithium and valproate, which cause a decrease in intracellular inositol, effect a decrease in INM1 expression. Inositol 68-76 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 99-103 10928550-2 2000 Counteracting compounds (sorbitol, mannitol or inositol), despite slightly (10-20%) inhibiting the ATPase activity, also protect the F0F1-ATPase against denaturation by urea. Inositol 47-55 dynein axonemal heavy chain 8 Homo sapiens 99-105 10928550-2 2000 Counteracting compounds (sorbitol, mannitol or inositol), despite slightly (10-20%) inhibiting the ATPase activity, also protect the F0F1-ATPase against denaturation by urea. Inositol 47-55 ATP synthase F1 subunit epsilon Homo sapiens 133-144 10767323-5 2000 NTD risk is reduced in various models by different maternal nutrient supplements, including folic acid ( Pax3, Cart1, Cd mutants), inositol ( ct ) and methionine ( Axd ). Inositol 131-139 fuzzy planar cell polarity protein Homo sapiens 0-3 10789675-0 2000 The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. Inositol 26-34 inositol polyphosphate phosphatase like 1 Homo sapiens 49-54 10789675-0 2000 The SH2 domain containing inositol 5-phosphatase SHIP2 associates to the immunoreceptor tyrosine-based inhibition motif of Fc gammaRIIB in B cells under negative signaling. Inositol 26-34 Fc gamma receptor IIb Homo sapiens 123-135 10747047-6 2000 However, when grown in liquid culture in medium containing limiting amounts of inositol, the opi1Delta ino4Delta strain exhibited a level of INO1 expression comparable to, or higher than, the wild-type strain growing under the same conditions. Inositol 79-87 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 93-97 10747047-7 2000 Furthermore, INO1 expression in the opi1Delta ino4Delta strain was repressed in cells grown in medium fully supplemented with both inositol and choline. Inositol 131-139 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 13-17 10747047-7 2000 Furthermore, INO1 expression in the opi1Delta ino4Delta strain was repressed in cells grown in medium fully supplemented with both inositol and choline. Inositol 131-139 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 36-40 10764144-7 2000 These findings suggest a potential link between MLL fusion-mediated leukaemogenesis and the inositol-signalling pathway. Inositol 92-100 lysine methyltransferase 2A Homo sapiens 48-51 10823574-0 2000 Ts65Dn mouse, a Down syndrome model, exhibits elevated myo-inositol in selected brain regions and peripheral tissues. Inositol 55-67 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 0-6 10823574-2 2000 In the present study, we examined brain regions and peripheral tissues of Ts65Dn mouse, a recently characterized genetic model of DS, for abnormal myo-inositol accumulation. Inositol 147-159 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 74-80 10823574-7 2000 The Ts65Dn mouse is useful to study the possible effect of elevated myo-inositol on cellular processes. Inositol 68-80 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 4-10 10713523-1 2000 The conversion of glucose 6-phosphate to 1-L-myo-inositol 1--phosphate (MIP) by 1-L-myo-inositol 1-phosphate synthase (MIP synthase) is the first committed and rate-limiting step in the de novo biosynthesis of inositol in all eukaryotes. Inositol 49-57 inositol-3-phosphate synthase 1 Homo sapiens 119-131 10704820-7 2000 Moreover, although p85/p110 PI-kinase almost exclusively phosphorylates the D-3 position of the inositol ring in phosphoinositides when purified PI is used as a substrate in vitro, it appears to phosphorylate the D-4 position with similar or higher efficiency in vivo. Inositol 96-104 phosphoinositide-3-kinase regulatory subunit 1 Homo sapiens 19-22 10779265-5 2000 A logistic regression model was used to investigate the confounding effect of duration of mechanical ventilation and oxygen therapy, birthweight, Apgar score, and serum inositol concentration on development of ROP. Inositol 169-177 opsin 1, long wave sensitive Homo sapiens 210-213 10779265-6 2000 RESULTS: Infants receiving high inositol formula and with higher serum inositol concentrations at birth and after 30 days had a statistically significant lower incidence of severe ROP than those receiving the lower inositol formula and with lower serum concentrations (P<.05). Inositol 32-40 opsin 1, long wave sensitive Homo sapiens 180-183 10779265-6 2000 RESULTS: Infants receiving high inositol formula and with higher serum inositol concentrations at birth and after 30 days had a statistically significant lower incidence of severe ROP than those receiving the lower inositol formula and with lower serum concentrations (P<.05). Inositol 71-79 opsin 1, long wave sensitive Homo sapiens 180-183 10779265-6 2000 RESULTS: Infants receiving high inositol formula and with higher serum inositol concentrations at birth and after 30 days had a statistically significant lower incidence of severe ROP than those receiving the lower inositol formula and with lower serum concentrations (P<.05). Inositol 71-79 opsin 1, long wave sensitive Homo sapiens 180-183 10779265-8 2000 By logistic regression, the odds of developing severe ROP were greater among infants with low serum inositol concentration (odds ratio=4.7, 95% confidence interval 0.90-24.8, P=.017). Inositol 100-108 opsin 1, long wave sensitive Homo sapiens 54-57 10779265-9 2000 CONCLUSION: Inositol supplementation may help prevent the most severe form of ROP. Inositol 12-20 opsin 1, long wave sensitive Homo sapiens 78-81 10809447-2 2000 PI is synthesized from CDP-diacylglycerol (CDP-DG) and myo-inositol by phosphatidylinositol synthase (PI synthase, EC 2.7.8.11). Inositol 55-67 phosphatidylinositol synthase 1 Arabidopsis thaliana 71-100 10809447-2 2000 PI is synthesized from CDP-diacylglycerol (CDP-DG) and myo-inositol by phosphatidylinositol synthase (PI synthase, EC 2.7.8.11). Inositol 55-67 phosphatidylinositol synthase 1 Arabidopsis thaliana 102-113 10809447-5 2000 AtPIS1 functionally complements a mutant of S. cerevisiae with a lesion in PI synthase, and recombinant AtPIS1 protein present in yeast membranes strongly depends on the two principal substrates, myo-inositol and CDP-DG, and requires Mg2+ ions for full activity. Inositol 196-208 phosphatidylinositol synthase 1 Arabidopsis thaliana 0-6 10809447-5 2000 AtPIS1 functionally complements a mutant of S. cerevisiae with a lesion in PI synthase, and recombinant AtPIS1 protein present in yeast membranes strongly depends on the two principal substrates, myo-inositol and CDP-DG, and requires Mg2+ ions for full activity. Inositol 196-208 phosphatidylinositol synthase 1 Arabidopsis thaliana 75-86 10809447-5 2000 AtPIS1 functionally complements a mutant of S. cerevisiae with a lesion in PI synthase, and recombinant AtPIS1 protein present in yeast membranes strongly depends on the two principal substrates, myo-inositol and CDP-DG, and requires Mg2+ ions for full activity. Inositol 196-208 phosphatidylinositol synthase 1 Arabidopsis thaliana 104-110 10718292-0 2000 Brain myo-inositol level is elevated in Ts65Dn mouse and reduced after lithium treatment. Inositol 6-18 reciprocal translocation, Chr 16, cytogenetic band C3-4; and Chr 17, cytogenetic band A2, Davisson 65 Mus musculus 40-46 10706103-0 2000 A germ-line p53 mutation accelerates pulmonary tumorigenesis: p53-independent efficacy of chemopreventive agents green tea or dexamethasone/myo-inositol and chemotherapeutic agents taxol or adriamycin. Inositol 140-152 transformation related protein 53, pseudogene Mus musculus 12-15 10706103-9 2000 Mice treated with dexamethasone/myo-inositol and green tea displayed an average of 70 and 50% inhibition of lung tumors, respectively, regardless of p53 status. Inositol 32-44 transformation related protein 53, pseudogene Mus musculus 149-152 10728889-2 2000 In the CNS the activity of SMIT also determines the individual susceptibility of neural cells to the inositol depleting effect of lithium, which is considered to be important in lithium"s therapeutic effects in manic-depressive illness. Inositol 101-109 solute carrier family 5 member 3 Rattus norvegicus 27-31 10728889-8 2000 The efficacy of uptake as determined by v(max) values of 3[H]myo-inositol uptake correlated with the level of mRNA of SMIT in the astrocyte cultures from the various brain regions as determined by semiquantitative reverse transcription-polymerase chain reaction (RT-PCR). Inositol 61-73 solute carrier family 5 member 3 Rattus norvegicus 118-122 10718121-2 2000 The formation of metabolite intermediate (MI)-complexes between cytochrome P450 (CYP) and the alkylamine-substituted drugs diltiazem (DTZ) and desipramine (DES) and their effect on CYP activities was investigated in rat liver. Inositol 42-44 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 64-79 10718121-2 2000 The formation of metabolite intermediate (MI)-complexes between cytochrome P450 (CYP) and the alkylamine-substituted drugs diltiazem (DTZ) and desipramine (DES) and their effect on CYP activities was investigated in rat liver. Inositol 42-44 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 81-84 10718121-2 2000 The formation of metabolite intermediate (MI)-complexes between cytochrome P450 (CYP) and the alkylamine-substituted drugs diltiazem (DTZ) and desipramine (DES) and their effect on CYP activities was investigated in rat liver. Inositol 42-44 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 181-184 10625610-1 2000 The yeast protein Sac1p is involved in a range of cellular functions, including inositol metabolism, actin cytoskeletal organization, endoplasmic reticulum ATP transport, phosphatidylinositol-phosphatidylcholine transfer protein function, and multiple-drug sensitivity. Inositol 80-88 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 18-23 11783535-0 2000 Purines, lactate and myo-inositol in CSF might reflect excitotoxicity in inherited metabolic disorders. Inositol 21-33 colony stimulating factor 2 Homo sapiens 37-40 11034685-3 2000 OBJECTIVES: To assess the effectiveness/safety of supplementary inositol in preterm infants with RDS in reducing adverse neonatal outcomes. Inositol 64-72 peripherin 2 Homo sapiens 97-100 10796200-3 2000 OBJECTIVES: To assess the effectiveness/safety of supplementary inositol in preterm infants with RDS in reducing adverse neonatal outcomes. Inositol 64-72 peripherin 2 Homo sapiens 97-100 10773690-5 2000 An increased Slc5a3 copy number may explain the increased levels of myo-inositol in the brains of trisomy 16 mice and the increased rate of transport of myo-inositol into cultured neurons derived from trisomy 16 mice. Inositol 68-80 solute carrier family 5 (inositol transporters), member 3 Mus musculus 13-19 10773690-5 2000 An increased Slc5a3 copy number may explain the increased levels of myo-inositol in the brains of trisomy 16 mice and the increased rate of transport of myo-inositol into cultured neurons derived from trisomy 16 mice. Inositol 153-165 solute carrier family 5 (inositol transporters), member 3 Mus musculus 13-19 11117673-3 2000 Furthermore, a deficiency in a specific D-chiro-inositol-containing IPG may contribute to insulin resistance in women with PCOS. Inositol 40-56 insulin Homo sapiens 90-97 10585408-8 1999 A detailed analysis of the inositol metabolites showed increased levels of glycerophosphoinositol, Ins(1)P, Ins(2)P, and lysophosphatidylinositol (lyso-PtdIns) in SPI8 cells, whereas the levels of phosphatidylinositol (PtdIns) and phosphatidylinositol 4, 5-bisphosphate were the same as those in control cells. Inositol 27-35 serine (or cysteine) peptidase inhibitor, clade B, member 8 Mus musculus 163-167 10582587-5 1999 Lithium"s effects on cJun-mediated reporter gene expression in SH-SY5Y cells were more pronounced in the absence of myo-inositol and were blocked by protein kinase C (PKC) inhibitors and by cotransfection with a PKCalpha dominant-negative mutant. Inositol 116-128 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 21-25 10544041-1 1999 These studies were performed to evaluate the effect of 2-aminoethoxydiphenyl borate (2-APB), a novel membrane-permeable inositol 1,4,5-trisphosphate-receptor inhibitor on agonist-induced, spontaneous, and KCl-stimulated in vitro myometrial contractions. Inositol 120-128 arginyl aminopeptidase Homo sapiens 87-90 10536117-5 1999 SP-D bound to live P. aeruginosa, and binding was inhibited by chelation of calcium and by a competing saccharide, inositol. Inositol 115-123 surfactant protein D Rattus norvegicus 0-4 10624568-9 1999 These data suggest that a strategy for development of therapeutic agents for APS may be based on the use of small cyclic, organic oligoanions such as inositol derivatives to act as ligands for lysine residues at the PL binding site of beta 2GPI. Inositol 150-158 apolipoprotein H Homo sapiens 235-244 10516282-1 1999 The enzyme phosphatidylinositide 3-kinase (PI3K) phosphorylates the D-3 position of the inositol ring of inositol phospholipids and produces 3-phosphorylated inositides. Inositol 88-96 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 11-41 10544922-7 1999 Adenosine-5"-phosphate-3"-phosphosulfate, a P2Y1 receptor antagonist, completely blocked ADP-induced inositol 1,4,5-trisphosphate and inositol 1,3.4-trisphosphate formation suggesting that P2TAC-mediated activation of Gi (or other G proteins) does not activate phospholipase C. These results suggest that a signaling event downstream from Gi, independent of the inhibition of platelet adenylyl cyclase, contributes to alphaIIb beta3 activation. Inositol 101-109 purinergic receptor P2Y1 Homo sapiens 44-57 10456901-3 1999 Rat SP-D but not rat SP-A bound the conidia, and the binding was inhibited by EDTA, mannose, glucose, maltose, and inositol. Inositol 115-123 surfactant protein D Rattus norvegicus 4-8 10461922-5 1999 The rat brain iPLA2 also showed a head group preference for choline > or = ethanolamine >> inositol. Inositol 100-108 phospholipase A2 group VI Rattus norvegicus 14-19 10462494-0 1999 Mouse phosphoinositide 3-kinase p110alpha gene: cloning, structural organization, and localization to chromosome 3 band B. Phosphoinositide 3-Kinases (PI3-Kinases) are a family of dual specificity enzymes with a unique lipid kinase activity toward the D-3 position of the inositol ring of phosphoinositides and a less well characterized serine/threonine protein kinase activity. Inositol 272-280 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 32-41 10501653-0 1999 Diabetes and the role of inositol-containing lipids in insulin signaling. Inositol 25-33 insulin Homo sapiens 55-62 10501653-7 1999 Although all the elements within the type II diabetes phenotype have not been fully defined, it has been proposed that defects in insulin transmembrane signaling through malfunction of inositol-containing phospholipid metabolism and absenteeism of the generation of phospholipid-derived second messengers may be associated with the appearance of the type II diabetic phenotype. Inositol 185-193 insulin Homo sapiens 130-137 10455234-6 1999 SAC1 encodes a protein which has been previously implicated in the correct function of the actin cytoskeleton, in inositol metabolism, in ATP transport in the endoplasmic reticulum and in Sec14p (PI-TP) function. Inositol 114-122 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 0-4 10419527-0 1999 p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. Inositol 26-34 extracellular matrix protein 1 Mus musculus 0-3 10419527-0 1999 p85/p110-type phosphatidylinositol kinase phosphorylates not only the D-3, but also the D-4 position of the inositol ring. Inositol 26-34 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Mus musculus 4-8 10398304-8 1999 Both neuronal differentiation and beta-catenin accumulation are observed in lithium-treated cells either in the absence or in the presence of supraphysiological concentrations of inositol. Inositol 179-187 catenin (cadherin associated protein), beta 1 Mus musculus 34-46 10407166-2 1999 Myo-inositol is accumulated into cells through Na(+)/myo-inositol cotransporter (SMIT). Inositol 0-12 solute carrier family 5 member 3 Rattus norvegicus 81-85 10395542-1 1999 In studies of developmental signaling pathways stimulated by the Wnt proteins and their receptors, Xenopus Wnt-5A (Xwnt-5A) and a prospective Wnt receptor, rat Frizzled 2 (Rfz2), have been shown to stimulate inositol signaling and Ca2+ fluxes in zebrafish [1] [2] [3]. Inositol 208-216 Wnt family member 5A S homeolog Xenopus laevis 107-113 10395542-1 1999 In studies of developmental signaling pathways stimulated by the Wnt proteins and their receptors, Xenopus Wnt-5A (Xwnt-5A) and a prospective Wnt receptor, rat Frizzled 2 (Rfz2), have been shown to stimulate inositol signaling and Ca2+ fluxes in zebrafish [1] [2] [3]. Inositol 208-216 Wnt family member 5A S homeolog Xenopus laevis 115-122 10395542-1 1999 In studies of developmental signaling pathways stimulated by the Wnt proteins and their receptors, Xenopus Wnt-5A (Xwnt-5A) and a prospective Wnt receptor, rat Frizzled 2 (Rfz2), have been shown to stimulate inositol signaling and Ca2+ fluxes in zebrafish [1] [2] [3]. Inositol 208-216 frizzled class receptor 2 Rattus norvegicus 160-170 10395542-1 1999 In studies of developmental signaling pathways stimulated by the Wnt proteins and their receptors, Xenopus Wnt-5A (Xwnt-5A) and a prospective Wnt receptor, rat Frizzled 2 (Rfz2), have been shown to stimulate inositol signaling and Ca2+ fluxes in zebrafish [1] [2] [3]. Inositol 208-216 frizzled class receptor 2 Rattus norvegicus 172-176 10393611-1 1999 The Na+/myo-inositol cotransporter (SLC5A3) gene, located on the long arm of human chromosome 21, may play a key role in osmoregulation including the regulation of levels of the "idiogenic osmole," myo-inositol, in brain cells. Inositol 8-20 solute carrier family 5 member 3 Homo sapiens 36-42 10397762-0 1999 Pleiotropic alterations in lipid metabolism in yeast sac1 mutants: relationship to "bypass Sec14p" and inositol auxotrophy. Inositol 103-111 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 53-57 10397762-9 1999 Finally, we determine that CDP-choline pathway activity contributes to the inositol auxotrophy of sac1 strains in a novel manner that does not involve obvious defects in transcriptional expression of the INO1 gene. Inositol 75-83 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 98-102 10407264-2 1999 The ICRE (inositol/choline-responsive element), which is necessary and sufficient for regulation by phospholipid precursors, functions as a binding site for the heterodimeric Ino2/Ino4 activator. Inositol 10-18 Ino2p Saccharomyces cerevisiae S288C 175-179 10407264-2 1999 The ICRE (inositol/choline-responsive element), which is necessary and sufficient for regulation by phospholipid precursors, functions as a binding site for the heterodimeric Ino2/Ino4 activator. Inositol 10-18 Ino4p Saccharomyces cerevisiae S288C 180-184 10407264-10 1999 Overexpression of OPI1 under control of the GAL1 promoter severely inhibited activation of ICRE-dependent genes, leading to inositol-requiring cells. Inositol 124-132 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 18-22 10407264-10 1999 Overexpression of OPI1 under control of the GAL1 promoter severely inhibited activation of ICRE-dependent genes, leading to inositol-requiring cells. Inositol 124-132 galactokinase Saccharomyces cerevisiae S288C 44-48 10362505-8 1999 These findings indicate that the main components of the noncanonical and canonical inositol lipid signal transduction pathways, including PI 3-K, PLC beta2 and beta3, PLC gamma2, undergo nuclear translocation and may therefore play a relevant role during monocytic differentiation at the nuclear level. Inositol 83-91 phospholipase C beta 2 Homo sapiens 146-165 10362505-8 1999 These findings indicate that the main components of the noncanonical and canonical inositol lipid signal transduction pathways, including PI 3-K, PLC beta2 and beta3, PLC gamma2, undergo nuclear translocation and may therefore play a relevant role during monocytic differentiation at the nuclear level. Inositol 83-91 phospholipase C gamma 2 Homo sapiens 167-177 10362595-1 1999 myo-Inositol is a ubiquitous intracellular organic osmolyte and phosphoinositide precursor maintained at millimolar intracellular concentrations through the action of membrane-associated Na+-myo-inositol cotransporters (SMIT). Inositol 0-12 solute carrier family 5 member 3 Homo sapiens 220-224 10341214-3 1999 Here we demonstrate that in vitro, recombinant cytohesin-1 binds, via its PH domain, the inositol head group of PIP3, inositol 1,3,4, 5-tetrakisphosphate (IP4), with an affinity greater than 200-fold higher than the inositol head group of either phosphatidylinositol 4, 5-bisphosphate or phosphatidylinositol 3,4-bisphosphate. Inositol 89-97 cytohesin 1 Rattus norvegicus 47-58 10341214-3 1999 Here we demonstrate that in vitro, recombinant cytohesin-1 binds, via its PH domain, the inositol head group of PIP3, inositol 1,3,4, 5-tetrakisphosphate (IP4), with an affinity greater than 200-fold higher than the inositol head group of either phosphatidylinositol 4, 5-bisphosphate or phosphatidylinositol 3,4-bisphosphate. Inositol 118-126 cytohesin 1 Rattus norvegicus 47-58 10224133-8 1999 These data suggest that BPntase"s physiologic role in nucleotide metabolism may be regulated by inositol signaling pathways. Inositol 96-104 3'(2'), 5'-bisphosphate nucleotidase 1 Homo sapiens 24-31 10224142-8 1999 Three of these substrates were identified as the tyrosine kinase pp72(syk), the phospholipase Cgamma2, and the inositol 5-phosphatase SHIP. Inositol 111-119 spleen associated tyrosine kinase Homo sapiens 70-73 10224142-8 1999 Three of these substrates were identified as the tyrosine kinase pp72(syk), the phospholipase Cgamma2, and the inositol 5-phosphatase SHIP. Inositol 111-119 inositol polyphosphate-5-phosphatase D Homo sapiens 134-138 10224244-3 1999 Dominant mutations in SNF4 and recessive mutations in REG1, OPI1, and RTF2 were isolated that specifically suppress the inositol auxotrophy of the TBP mutant strains. Inositol 120-128 AMP-activated serine/threonine-protein kinase regulatory subunit SNF4 Saccharomyces cerevisiae S288C 22-26 10224244-3 1999 Dominant mutations in SNF4 and recessive mutations in REG1, OPI1, and RTF2 were isolated that specifically suppress the inositol auxotrophy of the TBP mutant strains. Inositol 120-128 protein phosphatase regulator REG1 Saccharomyces cerevisiae S288C 54-58 10224244-3 1999 Dominant mutations in SNF4 and recessive mutations in REG1, OPI1, and RTF2 were isolated that specifically suppress the inositol auxotrophy of the TBP mutant strains. Inositol 120-128 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 60-64 10224244-3 1999 Dominant mutations in SNF4 and recessive mutations in REG1, OPI1, and RTF2 were isolated that specifically suppress the inositol auxotrophy of the TBP mutant strains. Inositol 120-128 TATA-binding protein Saccharomyces cerevisiae S288C 147-150 10224245-0 1999 The REG1 gene product is required for repression of INO1 and other inositol-sensitive upstream activating sequence-containing genes of yeast. Inositol 67-75 protein phosphatase regulator REG1 Saccharomyces cerevisiae S288C 4-8 10224245-1 1999 A search was conducted for suppressors of the inositol auxotrophic phenotype of the ino4-8 mutant of yeast. Inositol 46-54 Ino4p Saccharomyces cerevisiae S288C 84-88 10224245-5 1999 The suppressor mutation, sia1-1, identified as an allele of REG1, caused constitutive INO1 expression and was capable of suppressing the inositol auxotrophy of a second ino4 missense mutant, ino4-26, as well as ino2-419, a missense mutation of INO2. Inositol 137-145 Sia1p Saccharomyces cerevisiae S288C 25-31 10224245-5 1999 The suppressor mutation, sia1-1, identified as an allele of REG1, caused constitutive INO1 expression and was capable of suppressing the inositol auxotrophy of a second ino4 missense mutant, ino4-26, as well as ino2-419, a missense mutation of INO2. Inositol 137-145 protein phosphatase regulator REG1 Saccharomyces cerevisiae S288C 60-64 10224245-5 1999 The suppressor mutation, sia1-1, identified as an allele of REG1, caused constitutive INO1 expression and was capable of suppressing the inositol auxotrophy of a second ino4 missense mutant, ino4-26, as well as ino2-419, a missense mutation of INO2. Inositol 137-145 Ino4p Saccharomyces cerevisiae S288C 169-173 10224245-5 1999 The suppressor mutation, sia1-1, identified as an allele of REG1, caused constitutive INO1 expression and was capable of suppressing the inositol auxotrophy of a second ino4 missense mutant, ino4-26, as well as ino2-419, a missense mutation of INO2. Inositol 137-145 Ino4p Saccharomyces cerevisiae S288C 191-195 10361278-1 1999 Structural genes of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae are activated by the Ino2p/Ino4p transcription factor that binds to ICRE promoter motifs and mediates maximal gene expression in the absence of inositol. Inositol 228-236 Ino2p Saccharomyces cerevisiae S288C 105-110 10361278-1 1999 Structural genes of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae are activated by the Ino2p/Ino4p transcription factor that binds to ICRE promoter motifs and mediates maximal gene expression in the absence of inositol. Inositol 228-236 Ino4p Saccharomyces cerevisiae S288C 111-116 10361278-2 1999 We identified the ino80 mutation causing inositol auxotrophy as a result of a defect in ICRE-dependent gene activation. Inositol 41-49 chromatin-remodeling ATPase INO80 Saccharomyces cerevisiae S288C 18-23 10198439-1 1999 The INO1 gene of yeast is expressed in logarithmically growing, wild-type cells when inositol is absent from the medium. Inositol 85-93 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 10198439-2 1999 However, the INO1 gene is repressed when inositol is present during logarithmic growth and it is also repressed as cells enter stationary phase whether inositol is present or not. Inositol 41-49 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 13-17 10198439-2 1999 However, the INO1 gene is repressed when inositol is present during logarithmic growth and it is also repressed as cells enter stationary phase whether inositol is present or not. Inositol 152-160 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 13-17 10198439-4 1999 The repression of INO1 in response to nitrogen limitation shares many features in common with repression in response to the presence of inositol. Inositol 136-144 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 18-22 10198439-6 1999 Thus, we propose that repression of INO1 in response to inositol and in response to nitrogen limitation occurs via a common mechanism that is sensitive to the status of ongoing phospholipid metabolism. Inositol 56-64 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 36-40 10394997-1 1999 RATIONALE: Myo-inositol is an isomer of glucose that is a precursor in the phosphatidylinositol (PIP) cycle, a source of two second messengers: diacylglycerol (DAG) and inositol triphosphate (IP3). Inositol 11-23 prolactin induced protein Homo sapiens 97-100 10219066-1 1999 BACKGROUND: Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a D-chiro-inositol-containing phosphoglycan that mediates the action of insulin. Inositol 137-153 insulin Homo sapiens 58-65 10219066-1 1999 BACKGROUND: Women with the polycystic ovary syndrome have insulin resistance and hyperinsulinemia, possibly because of a deficiency of a D-chiro-inositol-containing phosphoglycan that mediates the action of insulin. Inositol 137-153 insulin Homo sapiens 86-93 10219066-2 1999 We hypothesized that the administration of D-chiro-inositol would replenish stores of the mediator and improve insulin sensitivity. Inositol 43-59 insulin Homo sapiens 111-118 10219066-5 1999 RESULTS: In the 22 women given D-chiro-inositol, the mean (+/-SD) area under the plasma insulin curve after the oral administration of glucose decreased from 13,417+/-11,572 to 5158+/-6714 microU per milliliter per minute (81+/-69 to 31+/-40 nmol per liter per minute) (P=0.007; P=0.07 for the comparison of this change with the change in the placebo group); glucose tolerance did not change significantly. Inositol 31-47 insulin Homo sapiens 88-95 10219066-10 1999 CONCLUSIONS: D-Chiro-inositol increases the action of insulin in patients with the polycystic ovary syndrome, thereby improving ovulatory function and decreasing serum androgen concentrations, blood pressure, and plasma triglyceride concentrations. Inositol 13-29 insulin Homo sapiens 54-61 10201978-7 1999 The coaggregation of c-kit with Fc gamma RIIB did not affect ligand-induced c-kit phosphorylation and induced the tyrosyl-phosphorylation of Fc gamma RIIB, which selectively recruited the Src homology 2 domain-bearing inositol 5-phosphatase SHIP. Inositol 218-226 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 21-26 10201978-7 1999 The coaggregation of c-kit with Fc gamma RIIB did not affect ligand-induced c-kit phosphorylation and induced the tyrosyl-phosphorylation of Fc gamma RIIB, which selectively recruited the Src homology 2 domain-bearing inositol 5-phosphatase SHIP. Inositol 218-226 Fc gamma receptor IIb Homo sapiens 32-45 10201978-7 1999 The coaggregation of c-kit with Fc gamma RIIB did not affect ligand-induced c-kit phosphorylation and induced the tyrosyl-phosphorylation of Fc gamma RIIB, which selectively recruited the Src homology 2 domain-bearing inositol 5-phosphatase SHIP. Inositol 218-226 Fc gamma receptor IIb Homo sapiens 141-154 10209156-1 1999 Phosphoinositide 3-kinases (PI3Ks) phosphorylate inositol lipids at the 3" position of the inositol ring to generate the 3-phosphoinositides PI(3)P, PI(3,4) P2 and PI(3,4,5) P3. Inositol 49-57 peptidase inhibitor 3 Homo sapiens 149-159 10098512-4 1999 To address this question, we first assessed the direct GRF effect on second messenger activation in cultures of LD and HD cells by measuring cAMP levels and [3H]myo-inositol incorporation. Inositol 161-173 growth hormone releasing hormone Sus scrofa 55-58 10215872-1 1999 We have recently cloned the cDNA of p42IP4, a membrane-associated and cytosolic inositol (1,3,4,5)tetrakisphosphate receptor protein [Stricker, R., Hulser, E., Fischer, J., Jarchau, T., Walter, U., Lottspeich, F. & Reiser, G. (1997) FEBS Lett. Inositol 80-88 ArfGAP with dual PH domains 1 Rattus norvegicus 36-42 10215872-7 1999 The recombinant purified protein is active because it shows binding affinities similar to those of the native p42IP4, purified from pig cerebellum or rat brain (Ki for inositol(1,3,4,5)P4 of 4.1 nm and 2.2 nm, respectively). Inositol 168-177 ArfGAP with dual PH domains 1 Rattus norvegicus 110-116 10217416-2 1999 Co-expression of the last 86 residues of the C-terminal tail of mGluR1alpha (F2-protein) with mGluR1alpha caused a significant reduction of the amount of the cell surface receptor when compared to that in cells transfected with mGlur1alpha alone, and this was accompanied by a reduction in the production of inositol following agonist stimulation of the cells. Inositol 308-316 glutamate metabotropic receptor 1 Homo sapiens 64-70 10209098-4 1999 Furthermore, PTEN regulates the levels of phosphatidylinositol 3,4,5-trisphosphate (PIP3) by specifically dephosphorylating position 3 on the inositol ring [8]. Inositol 54-62 phosphatase and tensin homolog Homo sapiens 13-17 10075922-3 1999 Sac1p shows no homology to other known solute transporters but displays similarity to the N-terminal non-catalytic domain of a subset of inositol 5"-phosphatases. Inositol 137-145 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 0-5 10027932-1 1999 BACKGROUND: The sodium/myo-inositol cotransporter (SMIT) and the betaine cotransporter (BGT1) are essential for the accumulation of myo-inositol and betaine, and hence cell survival in a hypertonic environment. Inositol 23-35 LOC100856716 Canis lupus familiaris 51-55 10027932-1 1999 BACKGROUND: The sodium/myo-inositol cotransporter (SMIT) and the betaine cotransporter (BGT1) are essential for the accumulation of myo-inositol and betaine, and hence cell survival in a hypertonic environment. Inositol 23-35 solute carrier family 6 member 12 Canis lupus familiaris 88-92 10069808-9 1999 However, mcd4-174 cells have a severe defect in incorporation of [3H]inositol into proteins and accumulate several previously uncharacterized [3H]inositol-labeled lipids whose properties are consistent with their being GPI precursors. Inositol 69-77 mannose-ethanolamine phosphotransferase MCD4 Saccharomyces cerevisiae S288C 9-13 10069808-9 1999 However, mcd4-174 cells have a severe defect in incorporation of [3H]inositol into proteins and accumulate several previously uncharacterized [3H]inositol-labeled lipids whose properties are consistent with their being GPI precursors. Inositol 146-154 mannose-ethanolamine phosphotransferase MCD4 Saccharomyces cerevisiae S288C 9-13 9927610-8 1999 In contrast, replacement of Asp113 by Ala residue in NTR1 strongly decreases its ability to activate inositol turnover, indicating that the functionally active conformation of NTR1 is maintained by interaction of sodium ions with aspartate 113. Inositol 101-109 neurotensin receptor 1 Homo sapiens 53-57 9927610-8 1999 In contrast, replacement of Asp113 by Ala residue in NTR1 strongly decreases its ability to activate inositol turnover, indicating that the functionally active conformation of NTR1 is maintained by interaction of sodium ions with aspartate 113. Inositol 101-109 neurotensin receptor 1 Homo sapiens 176-180 10096091-8 1999 As overexpression of IMPases increased intracellular free Ca2+, it is suggested that yeast IMPases are limiting for the optimal operation of the inositol cycle of calcium signalling, which modulates the Ena1 cation-extrusion ATPase. Inositol 145-153 Na(+)/Li(+)-exporting P-type ATPase ENA1 Saccharomyces cerevisiae S288C 203-207 9882452-4 1999 In these studies we show that TNFalpha causes a concentration- and time-dependent decrease in Na+/myo-inositol cotransporter (SMIT) mRNA levels and myo-inositol accumulation as well as a decrease in myo-inositol incorporation into phosphoinositides. Inositol 98-110 tumor necrosis factor Homo sapiens 30-38 9882452-4 1999 In these studies we show that TNFalpha causes a concentration- and time-dependent decrease in Na+/myo-inositol cotransporter (SMIT) mRNA levels and myo-inositol accumulation as well as a decrease in myo-inositol incorporation into phosphoinositides. Inositol 98-110 solute carrier family 5 member 3 Homo sapiens 126-130 9882452-4 1999 In these studies we show that TNFalpha causes a concentration- and time-dependent decrease in Na+/myo-inositol cotransporter (SMIT) mRNA levels and myo-inositol accumulation as well as a decrease in myo-inositol incorporation into phosphoinositides. Inositol 148-160 tumor necrosis factor Homo sapiens 30-38 9989274-12 1999 Structural analogs of myo-inositol, epi-inositol and scyllo-inositol and Zn2+ were shown to be more potent inhibitors of mycobacterial PI synthase than of mammalian analogs. Inositol 22-34 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 135-146 9989274-12 1999 Structural analogs of myo-inositol, epi-inositol and scyllo-inositol and Zn2+ were shown to be more potent inhibitors of mycobacterial PI synthase than of mammalian analogs. Inositol 36-48 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 135-146 10229296-0 1999 Effect of aldose reductase inhibitors on glucose-induced changes in sorbitol and myo-inositol metabolism in human neutrophils. Inositol 81-93 aldo-keto reductase family 1 member B Homo sapiens 10-26 10229296-7 1999 A 70% fall in the myo-inositol content in neutrophils exposed to 40mmol/glucose medium was attenuated approximately 40% by the addition of AR inhibitors. Inositol 18-30 aldo-keto reductase family 1 member B Homo sapiens 139-141 10229296-9 1999 AR inhibitors significantly ameliorated the decrease in myo-inositol uptake, but did not completely normalize it. Inositol 56-68 aldo-keto reductase family 1 member B Homo sapiens 0-2 10229296-10 1999 CONCLUSIONS: Our present in vitro studies showed that the glucose-induced metabolic alterations in human neutrophils were similar to those in tissues prone to diabetic complications, and that AR inhibitors effectively corrected glucose-induced imbalances of the polyol pathway and myo-inositol uptake in neutrophils. Inositol 281-293 aldo-keto reductase family 1 member B Homo sapiens 192-194 11097029-6 1999 Using PEL-lacZ fusion genes it was demonstrated that Pel1p is a mitochondrial protein (expressed in response to myo-inositol and choline). Inositol 112-124 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 53-58 9862864-3 1999 Quiescent stellate cells expressed in an osmosensitive manner the mRNA levels of the transporters for taurine (TAUT) and myoinositol (SMIT), whereas that for betaine was not detectable. Inositol 121-132 solute carrier family 5 member 3 Rattus norvegicus 134-138 9987137-12 1999 Although the null mutant can grow on both fermentable and non-fermentable carbon sources at lower temperatures, it cannot form colonies at 37 degrees C. In conclusion, CRD1 expression is controlled by factors affecting mitochondrial development, but not by the phospholipid precursors inositol and choline. Inositol 285-293 cardiolipin synthase Saccharomyces cerevisiae S288C 168-172 9820807-1 1998 Tumour necrosis factor alpha (TNF-alpha) regulates the transport of myo-inositol in 3T3-L1 adipocytes. Inositol 68-80 tumor necrosis factor Homo sapiens 30-39 9820807-2 1998 Treating 3T3-L1 adipocytes with TNF-alpha decreases Na+/myo-inositol co-transporter (SMIT) mRNA levels and myo-inositol accumulation in a concentration-and time-dependent manner. Inositol 56-68 tumor necrosis factor Homo sapiens 32-41 9820807-2 1998 Treating 3T3-L1 adipocytes with TNF-alpha decreases Na+/myo-inositol co-transporter (SMIT) mRNA levels and myo-inositol accumulation in a concentration-and time-dependent manner. Inositol 56-68 solute carrier family 5 member 3 Homo sapiens 85-89 9820807-6 1998 Hyperosmolarity increases SMIT gene expression as evidenced by the inhibition of hyperosmotic induction of SMIT mRNA levels by actinomycin D, and of myo-inositol accumulation by actinomycin D and cycloheximide. Inositol 149-161 solute carrier family 5 member 3 Homo sapiens 26-30 9820807-12 1998 Because myo-inositol in the form of phosphoinositides is an important component of membranes and signal transduction pathways, the regulation of myo-inositol metabolism by TNF-alpha might represent another mechanism by which TNF-alpha regulates adipocyte function. Inositol 8-20 tumor necrosis factor Homo sapiens 225-234 9820807-12 1998 Because myo-inositol in the form of phosphoinositides is an important component of membranes and signal transduction pathways, the regulation of myo-inositol metabolism by TNF-alpha might represent another mechanism by which TNF-alpha regulates adipocyte function. Inositol 145-157 tumor necrosis factor Homo sapiens 172-181 9820807-12 1998 Because myo-inositol in the form of phosphoinositides is an important component of membranes and signal transduction pathways, the regulation of myo-inositol metabolism by TNF-alpha might represent another mechanism by which TNF-alpha regulates adipocyte function. Inositol 145-157 tumor necrosis factor Homo sapiens 225-234 10395202-1 1998 Previous studies by our lab and others established that co-crosslinking sIg and IgG receptor FcgammaRIIb in B cells in a feedback suppression model (negative signaling) promoted tyrosine phosphorylation of the inositol 5-phosphatase SHIP and its interaction with Shc and that these events were associated with inhibition of the Ras pathway. Inositol 210-218 Fc gamma receptor IIb Homo sapiens 93-104 10395202-1 1998 Previous studies by our lab and others established that co-crosslinking sIg and IgG receptor FcgammaRIIb in B cells in a feedback suppression model (negative signaling) promoted tyrosine phosphorylation of the inositol 5-phosphatase SHIP and its interaction with Shc and that these events were associated with inhibition of the Ras pathway. Inositol 210-218 inositol polyphosphate-5-phosphatase D Homo sapiens 233-237 10395202-1 1998 Previous studies by our lab and others established that co-crosslinking sIg and IgG receptor FcgammaRIIb in B cells in a feedback suppression model (negative signaling) promoted tyrosine phosphorylation of the inositol 5-phosphatase SHIP and its interaction with Shc and that these events were associated with inhibition of the Ras pathway. Inositol 210-218 SHC adaptor protein 1 Homo sapiens 263-266 9849879-5 1998 A phylogenetic analysis of the PLC family and the protein kinase C (PKC) family, together with that of the G protein alpha subunit (Galpha) family, revealed that the origin of the set of genes G(alpha)q, PLC, PKC involved in the inositol phospholipid signaling pathway is very old, going back to dates before the parazoan-eumetazoan split, the earliest branching among extant animal phyla. Inositol 229-237 small wing Drosophila melanogaster 31-34 9849879-5 1998 A phylogenetic analysis of the PLC family and the protein kinase C (PKC) family, together with that of the G protein alpha subunit (Galpha) family, revealed that the origin of the set of genes G(alpha)q, PLC, PKC involved in the inositol phospholipid signaling pathway is very old, going back to dates before the parazoan-eumetazoan split, the earliest branching among extant animal phyla. Inositol 229-237 Protein C kinase 53E Drosophila melanogaster 50-66 9849879-5 1998 A phylogenetic analysis of the PLC family and the protein kinase C (PKC) family, together with that of the G protein alpha subunit (Galpha) family, revealed that the origin of the set of genes G(alpha)q, PLC, PKC involved in the inositol phospholipid signaling pathway is very old, going back to dates before the parazoan-eumetazoan split, the earliest branching among extant animal phyla. Inositol 229-237 Protein C kinase 53E Drosophila melanogaster 68-71 9849879-5 1998 A phylogenetic analysis of the PLC family and the protein kinase C (PKC) family, together with that of the G protein alpha subunit (Galpha) family, revealed that the origin of the set of genes G(alpha)q, PLC, PKC involved in the inositol phospholipid signaling pathway is very old, going back to dates before the parazoan-eumetazoan split, the earliest branching among extant animal phyla. Inositol 229-237 G protein alpha q subunit Drosophila melanogaster 107-130 9849879-5 1998 A phylogenetic analysis of the PLC family and the protein kinase C (PKC) family, together with that of the G protein alpha subunit (Galpha) family, revealed that the origin of the set of genes G(alpha)q, PLC, PKC involved in the inositol phospholipid signaling pathway is very old, going back to dates before the parazoan-eumetazoan split, the earliest branching among extant animal phyla. Inositol 229-237 G protein alpha q subunit Drosophila melanogaster 132-138 9849879-5 1998 A phylogenetic analysis of the PLC family and the protein kinase C (PKC) family, together with that of the G protein alpha subunit (Galpha) family, revealed that the origin of the set of genes G(alpha)q, PLC, PKC involved in the inositol phospholipid signaling pathway is very old, going back to dates before the parazoan-eumetazoan split, the earliest branching among extant animal phyla. Inositol 229-237 small wing Drosophila melanogaster 204-207 9849879-5 1998 A phylogenetic analysis of the PLC family and the protein kinase C (PKC) family, together with that of the G protein alpha subunit (Galpha) family, revealed that the origin of the set of genes G(alpha)q, PLC, PKC involved in the inositol phospholipid signaling pathway is very old, going back to dates before the parazoan-eumetazoan split, the earliest branching among extant animal phyla. Inositol 229-237 Protein C kinase 53E Drosophila melanogaster 209-212 9799398-1 1998 The myo-inositol transporter SMIT is expressed particularly at high extracellular osmolarity and serves to accumulate the osmolyte myo-inositol. Inositol 4-16 solute carrier family 5 member 3 S homeolog Xenopus laevis 29-33 9799398-3 1998 In Xenopus oocytes injected with mRNA encoding SMIT but not in water-injected oocytes, myo-inositol creates an inward current that is dependent on the ambient Na+ concentration. Inositol 87-99 solute carrier family 5 member 3 S homeolog Xenopus laevis 47-51 9799398-6 1998 The myo-inositol-induced currents in oocytes expressing SMIT were found to have a sigmoidal dependence on the ambient pH between pH 5.5 and 8.5 with an apparent Ki of 0.21+/-001 microM H+ and a Hill coefficient of 1.80+/-0.16. Inositol 4-16 solute carrier family 5 member 3 S homeolog Xenopus laevis 56-60 9799398-13 1998 In summary, acidification impedes SMIT-mediated myo-inositol transport at least partially by decreasing the affinity of the carrier for Na+. Inositol 48-60 solute carrier family 5 member 3 S homeolog Xenopus laevis 34-38 9840450-0 1998 Decreases in Raf-1 levels in galactosaemic lens epithelial cells are partially reversed by myo-inositol. Inositol 91-103 RAF1 Bos taurus 13-18 9840450-2 1998 A link between PKC changes and myo-inositol depletion has been suggested. Inositol 31-43 protein kinase C alpha Bos taurus 15-18 9840450-5 1998 Raf-1 levels were measured by densitometric scanning of Western blots from cells grown with or without 40 mmol/l galactose or 40 mmol/l galactose plus 1.0 micromol/l myo-inositol for 1, 3, 5 or 7 days. Inositol 166-178 RAF1 Bos taurus 0-5 9742223-4 1998 Human GRP1 binds, via its pleckstrin homology (PH) domain, the inositol head group of PtdIns(3,4,5)P3, inositol 1, 3,4,5-tetrakisphosphate [Ins(1,3,4,5)P4], with high affinity (Kd 32. Inositol 63-71 cytohesin 3 Homo sapiens 6-10 9799363-3 1998 The expression of the PEL1-lacZ reporter gene was repressed in cells grown in the presence of inositol and choline, reduced in the ino2 and ino4 strains, but constitutive in the opi1 null-mutant strain. Inositol 94-102 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 22-26 9802015-0 1998 Pleiotropic effects of the opi1 regulatory mutation of yeast: its effects on growth and on phospholipid and inositol metabolism. Inositol 108-116 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 27-31 9802015-5 1998 In the wild-type strain, INO1 expression was limited to a peak in the exponential phase of growth in cells grown in the absence of inositol. Inositol 131-139 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 25-29 9802015-7 1998 Intracellular inositol contents of the opi1 strain were higher than those of the wild-type strain, with peak levels occurring in the stationary phase. Inositol 14-22 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 39-43 9802015-8 1998 Membrane phosphatidylinositol content paralleled intracellular inositol content, with opi1 strains having a higher phosphatidylinositol content in stationary phase. Inositol 21-29 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 86-90 9748349-8 1998 The complete glycan core structure (Man3-GluN) of typical GPI anchors including a mannose side chain and the inositolphosphate moiety was required for maximal insulin-mimetic activity of the PIG compounds with some variations possible with respect to the type of residues coupled to the terminal mannose/inositol as well as the type of linkages involved. Inositol 109-117 insulin Sus scrofa 159-166 9736284-1 1998 Myo-inositol is a major compatible osmolyte in the renal medulla and is accumulated in cells under hypertonic conditions by uptake via a Na+/myo-inositol cotransporter (SMIT). Inositol 0-12 solute carrier family 5 member 3 Rattus norvegicus 169-173 9693122-0 1998 PTB domain of insulin receptor substrate-1 binds inositol compounds. Inositol 49-57 insulin receptor substrate 1 Homo sapiens 14-42 9688612-8 1998 We suggest that the Ca2+ influx-dependent regulation of the sustained KCa current in CCh-stimulated HSG cells is mediated by the uptake of Ca2+ into the internal Ca2+ store and release via the inositol 1,4,5-trisphosphate-sensitive channel. Inositol 193-201 casein kappa Homo sapiens 70-73 9691030-3 1998 Exploiting the ability of the inositol auxotroph, ino1, to use exogenous GroPIns as an inositol source, we have isolated mutants (Git-) defective in the uptake and metabolism of GroPIns. Inositol 30-38 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 50-54 9691030-3 1998 Exploiting the ability of the inositol auxotroph, ino1, to use exogenous GroPIns as an inositol source, we have isolated mutants (Git-) defective in the uptake and metabolism of GroPIns. Inositol 87-95 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 50-54 9668079-8 1998 These alterations were accompanied by an inositol excretion phenotype due to the misregulation of the INO1 gene. Inositol 41-49 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 102-106 9642212-4 1998 We now report that these choline and inositol excretion phenotypes are eliminated when the SPO14 (PLD1) gene encoding phospholipase D1 is deleted. Inositol 37-45 phospholipase D Saccharomyces cerevisiae S288C 91-96 9642212-4 1998 We now report that these choline and inositol excretion phenotypes are eliminated when the SPO14 (PLD1) gene encoding phospholipase D1 is deleted. Inositol 37-45 phospholipase D Saccharomyces cerevisiae S288C 98-102 9611229-2 1998 Removal of inositol results in transcriptional activation by heterodimeric complexes of two bHLH proteins, Ino2p and Ino4p. Inositol 11-19 Ino2p Saccharomyces cerevisiae S288C 107-112 9611229-2 1998 Removal of inositol results in transcriptional activation by heterodimeric complexes of two bHLH proteins, Ino2p and Ino4p. Inositol 11-19 Ino4p Saccharomyces cerevisiae S288C 117-122 9611229-3 1998 In the presence of inositol, transcription is repressed by Opi1p. Inositol 19-27 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 59-64 9611229-6 1998 The conditional lethality produced by nmt1-451D is rescued at temperatures up to 33 degreesC by withdrawal of inositol. Inositol 110-118 glycylpeptide N-tetradecanoyltransferase NMT1 Saccharomyces cerevisiae S288C 38-42 9611229-7 1998 We tested the hypothesis that N-myristoylproteins function to regulate INO2, INO4 and/or OPI1 transcription, thereby affecting the expression of inositol-sensitive genes that influence myristoylCoA metabolism. Inositol 145-153 Ino2p Saccharomyces cerevisiae S288C 71-75 9611229-9 1998 The activity of INO2 is significantly higher, INO4 significantly lower and OPI1 unaffected in nmt1-451D cells, both in the presence and absence of inositol. Inositol 147-155 Ino2p Saccharomyces cerevisiae S288C 16-20 9611229-10 1998 These changes are associated with a net increase in expression of some inositol target genes, including FAS1 . Inositol 71-79 tetrafunctional fatty acid synthase subunit FAS1 Saccharomyces cerevisiae S288C 104-108 9611229-16 1998 This factor is not functionally identical to Ino2p since other inositol-responsive genes (e.g. CHO1 ) maintain INO2 -dependent expression in nmt1-451D cells. Inositol 63-71 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 95-99 9611229-16 1998 This factor is not functionally identical to Ino2p since other inositol-responsive genes (e.g. CHO1 ) maintain INO2 -dependent expression in nmt1-451D cells. Inositol 63-71 Ino2p Saccharomyces cerevisiae S288C 111-115 9611229-16 1998 This factor is not functionally identical to Ino2p since other inositol-responsive genes (e.g. CHO1 ) maintain INO2 -dependent expression in nmt1-451D cells. Inositol 63-71 glycylpeptide N-tetradecanoyltransferase NMT1 Saccharomyces cerevisiae S288C 141-145 9633613-8 1998 Treatment of cells with the pyridinyl imidazole SB 203580 (10 microM), a specific inhibitor of p38 MAP kinase, inhibited the hyperosmolarity-induced increase in BGT-1 and SMIT mRNA as well as betaine and myoinositol uptake by 45-70%. Inositol 204-215 mitogen-activated protein kinase 14 Homo sapiens 95-98 9630608-1 1998 myo-Inositol is accumulated into cells by means of the Na+/myo-inositol cotransporter (SMIT), which is of interest because its activity is upregulated by hyperosmotic stress. Inositol 0-12 solute carrier family 5 member 3 Rattus norvegicus 87-91 9655509-0 1998 Synaptic defects and compensatory regulation of inositol metabolism in inositol polyphosphate 1-phosphatase mutants. Inositol 48-56 Inositol polyphosphate 1-phosphatase Drosophila melanogaster 71-107 9655509-5 1998 Notably, ipp mutants demonstrate compensatory upregulation of an alternative branch in the inositol-phosphate metabolism tree, thus providing a means of ensuring continued availability of inositol. Inositol 91-99 Inositol polyphosphate 1-phosphatase Drosophila melanogaster 9-12 9593664-4 1998 Purified recombinant PTEN catalyzed dephosphorylation of PtdIns(3,4,5)P3, specifically at position 3 on the inositol ring. Inositol 108-116 phosphatase and tensin homolog Homo sapiens 21-25 9565583-9 1998 In ino2 and ino4 mutants, gene expression was greatly reduced and was not subject to inositol regulation consistent with inositol repression being dependent on the INO2 and INO4 regulatory genes. Inositol 121-129 Ino2p Saccharomyces cerevisiae S288C 164-168 9565583-9 1998 In ino2 and ino4 mutants, gene expression was greatly reduced and was not subject to inositol regulation consistent with inositol repression being dependent on the INO2 and INO4 regulatory genes. Inositol 121-129 Ino4p Saccharomyces cerevisiae S288C 173-177 9565583-10 1998 PPGS1-lacZ expression was elevated in a cds1 null mutant in the presence or absence of inositol, indicating that the capacity to synthesize CDP-diacylglycerol affects gene expression. Inositol 87-95 phosphatidate cytidylyltransferase Saccharomyces cerevisiae S288C 40-44 9565585-2 1998 Structural studies of phospholipase C delta1 (PLCdelta1) in complexes with the inositol-lipid headgroup and calcium identified residues within the catalytic domain that could be involved in substrate recognition, calcium binding, and catalysis. Inositol 79-87 phospholipase C delta 1 Homo sapiens 22-44 9565585-2 1998 Structural studies of phospholipase C delta1 (PLCdelta1) in complexes with the inositol-lipid headgroup and calcium identified residues within the catalytic domain that could be involved in substrate recognition, calcium binding, and catalysis. Inositol 79-87 phospholipase C delta 1 Homo sapiens 46-55 9620547-6 1998 In addition, the inhibition of Ras GTP-binding is not blocked by excess free inositols suggesting that SOS binds to PtdIns4,5P2 with higher affinity than it binds to free inositols. Inositol 171-180 xylosyltransferase 2 Homo sapiens 103-106 9620547-8 1998 This confirmed that SOS inhibition is mediated by the SOS-PH domain binding to the inositol moiety of PtdIns4,5P2. Inositol 83-91 xylosyltransferase 2 Homo sapiens 20-23 9620547-8 1998 This confirmed that SOS inhibition is mediated by the SOS-PH domain binding to the inositol moiety of PtdIns4,5P2. Inositol 83-91 xylosyltransferase 2 Homo sapiens 54-57 9618071-7 1998 Supportive evidence linking these biochemical changes to the loss of nerve function has come from studies in which aldose reductase inhibitors block polyol pathway activity, prevent the depletion of myo-inositol and the accumulation of sodium and preserve Na/K ATPase activity, as well as nerve function. Inositol 199-211 aldo-keto reductase family 1 member B1 Rattus norvegicus 115-131 9618071-12 1998 Aldose reductase inhibitor treatment that preserved myo-inositol levels, Na/K ATPase, and conduction velocity in the sciatic nerve also preserved Na/K ATPase activity in RBCs. Inositol 52-64 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 9560389-9 1998 Analysis of inositol metabolites in vivo showed measurable accumulation of phosphatidylinositol 4,5-bisphosphate in the inp51 mutant. Inositol 12-20 phosphoinositide 5-phosphatase INP51 Saccharomyces cerevisiae S288C 120-125 9537365-0 1998 The Saccharomyces cerevisiae SCS2 gene product, a homolog of a synaptobrevin-associated protein, is an integral membrane protein of the endoplasmic reticulum and is required for inositol metabolism. Inositol 178-186 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 29-33 9537365-1 1998 The Saccharomyces cerevisiae SCS2 gene has been cloned as a suppressor of inositol auxotrophy of CSE1 and hac1/ire15 mutants (J. Nikawa, A. Murakami, E. Esumi, and K. Hosaka, J. Biochem. Inositol 74-82 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 29-33 9537365-1 1998 The Saccharomyces cerevisiae SCS2 gene has been cloned as a suppressor of inositol auxotrophy of CSE1 and hac1/ire15 mutants (J. Nikawa, A. Murakami, E. Esumi, and K. Hosaka, J. Biochem. Inositol 74-82 importin-alpha export receptor Saccharomyces cerevisiae S288C 97-101 9537365-5 1998 The disruption of the SCS2 gene causes yeast cells to exhibit inositol auxotrophy at temperatures of above 34 degrees C. Genetic studies reveal that the overexpression of the INO1 gene rescues the inositol auxotrophy of the SCS2 disruption strain. Inositol 62-70 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 22-26 9537365-5 1998 The disruption of the SCS2 gene causes yeast cells to exhibit inositol auxotrophy at temperatures of above 34 degrees C. Genetic studies reveal that the overexpression of the INO1 gene rescues the inositol auxotrophy of the SCS2 disruption strain. Inositol 62-70 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 175-179 9537365-5 1998 The disruption of the SCS2 gene causes yeast cells to exhibit inositol auxotrophy at temperatures of above 34 degrees C. Genetic studies reveal that the overexpression of the INO1 gene rescues the inositol auxotrophy of the SCS2 disruption strain. Inositol 197-205 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 22-26 9537365-5 1998 The disruption of the SCS2 gene causes yeast cells to exhibit inositol auxotrophy at temperatures of above 34 degrees C. Genetic studies reveal that the overexpression of the INO1 gene rescues the inositol auxotrophy of the SCS2 disruption strain. Inositol 197-205 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 175-179 9537365-5 1998 The disruption of the SCS2 gene causes yeast cells to exhibit inositol auxotrophy at temperatures of above 34 degrees C. Genetic studies reveal that the overexpression of the INO1 gene rescues the inositol auxotrophy of the SCS2 disruption strain. Inositol 197-205 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 224-228 9536026-4 1998 Recent studies have provided data in support of a role for protein kinase C and the down-regulation of expression of the myristoylated alanine-rich C kinase substrate (MARCKS) in the long-term therapeutic action of lithium in the brain, which is dependent on both the relative activity of receptor-coupled PI signaling and the concentration of myo-inositol. Inositol 344-356 myristoylated alanine rich protein kinase C substrate Homo sapiens 121-166 9536026-4 1998 Recent studies have provided data in support of a role for protein kinase C and the down-regulation of expression of the myristoylated alanine-rich C kinase substrate (MARCKS) in the long-term therapeutic action of lithium in the brain, which is dependent on both the relative activity of receptor-coupled PI signaling and the concentration of myo-inositol. Inositol 344-356 myristoylated alanine rich protein kinase C substrate Homo sapiens 168-174 9536026-5 1998 Our current results demonstrated that valproate induces a concentration- and time-dependent reduction of MARCKS in immortalized hippocampal cells that appears to be independent of both the level of muscarinic receptor-activated PI signaling as well as the concentration of myo-inositol. Inositol 273-285 myristoylated alanine rich protein kinase C substrate Homo sapiens 105-111 9612848-2 1998 Two hundred male albino Sprague-Dawley rats were studied for the lithium and/or inositol effect on 5-HTP induced prolactin release. Inositol 80-88 prolactin Rattus norvegicus 113-122 9462659-2 1998 This was investigated here by studying the effect of aniso-osmotic exposure of rat liver sinusoidal endothelial cells (SEC) on osmolyte transport and the messenger RNA (mRNA) levels for the transport systems for betaine (BGT1), taurine (TAUT), and myo-inositol (SMIT). Inositol 248-260 solute carrier family 6 member 12 Rattus norvegicus 221-225 9762362-1 1998 The nucleus was shown to be a site for inositol lipid cycle which can be affected by treatment of quiescent cells with growth factors such as IGF-I. Inositol 39-47 insulin-like growth factor 1 Mus musculus 142-147 9458713-3 1998 In contrast to the effect of hyperosmolarity, TNF-alpha caused a time- and concentration-dependent decrease in SMIT mRNA levels and myo-inositol accumulation. Inositol 132-144 tumor necrosis factor Bos taurus 46-55 9458713-4 1998 The effect of TNF-alpha on myo-inositol accumulation was found in large-vessel endothelial cells (derived from the aorta and pulmonary artery) and cerebral microvessel endothelial cells. Inositol 27-39 tumor necrosis factor Bos taurus 14-23 9458713-6 1998 TNF-alpha also increased ceramide levels, and C2-ceramide mimicked the effect of TNF-alpha on SMIT mRNA levels and myo-inositol accumulation in bovine aorta endothelial cells. Inositol 115-127 tumor necrosis factor Bos taurus 81-90 9458713-7 1998 Pyrrolidinedithiocarbamate, genistein, and 7-amino-1-chloro-3-tosylamido-2-hepatanone, compounds that can inhibit NF-kappa B activation, partially prevented the TNF-alpha-induced decrease in myo-inositol accumulation. Inositol 191-203 tumor necrosis factor Bos taurus 161-170 9458713-8 1998 The effect of TNF-alpha on myo-inositol accumulation was also partially prevented by the protein kinase C inhibitor calphostin C but not by staurosporine. Inositol 27-39 tumor necrosis factor Bos taurus 14-23 9458713-9 1998 These studies demonstrate that TNF-alpha causes a decrease in SMIT mRNA levels and myo-inositol accumulation in cultured endothelial cells, which may be related to the activation of NF-kappa B. Inositol 83-95 tumor necrosis factor Bos taurus 31-40 10212830-6 1998 A deficiency of the chiro-inositol system has been demonstrated in urine and tissues in humans and directly related to insulin resistance. Inositol 26-34 insulin Homo sapiens 119-126 10212830-9 1998 Thus, the pathophysiology in the chiro-inositol system related to insulin resistance and its reversal by chiro-inositol administration, in addition to the basic work, argues strongly for the physiological significance of this novel signaling system in the control of glucose metabolism. Inositol 39-47 insulin Homo sapiens 66-73 10212830-9 1998 Thus, the pathophysiology in the chiro-inositol system related to insulin resistance and its reversal by chiro-inositol administration, in addition to the basic work, argues strongly for the physiological significance of this novel signaling system in the control of glucose metabolism. Inositol 111-119 insulin Homo sapiens 66-73 9588758-1 1998 Lithium inhibits the enzyme inositol monophosphatase and thus obstructs the enzymatic degradation of inositol triphosphate (IP3) to inositol in the phosphate-phosphoinositide (PIP) cycle. Inositol 28-36 prolactin induced protein Homo sapiens 176-179 9453011-1 1998 Myo-inositol is a major compatible osmolyte in the renal medulla that is accumulated under hypertonic conditions via the Na+/myo-inositol cotransporter (SMIT). Inositol 0-12 solute carrier family 5 member 3 Rattus norvegicus 153-157 9453011-2 1998 We have recently reported that SMIT is predominantly present in the thick ascending limb of Henle (TAL) and is strongly induced by acute NaCl loading, suggesting an important role of myo-inositol in this nephron segment. Inositol 183-195 solute carrier family 5 member 3 Rattus norvegicus 31-35 16793683-5 1998 We conclude that the production of phosphoinositides phosphorylated on the D3 and D5 positions of the inositol ring is restricted to the plasma membrane and that only the enzymes that are present in, or relocated to, the plasma membrane when platelets are activated are stimulated by thrombin. Inositol 102-110 coagulation factor II, thrombin Homo sapiens 284-292 9407135-7 1997 Expression of the pis1 gene led to the overproduction of both phosphatidylinositol synthase and phosphatidylinositol:inositol exchange reactions, indicating that the Pis1 polypeptide catalyzed both of these activities. Inositol 74-82 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 18-22 9407135-7 1997 Expression of the pis1 gene led to the overproduction of both phosphatidylinositol synthase and phosphatidylinositol:inositol exchange reactions, indicating that the Pis1 polypeptide catalyzed both of these activities. Inositol 74-82 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 166-170 9434133-2 1997 The PH domain from pleckstrin bound inositol phosphates according to a number of phosphates on the inositol ring, i.e. more phosphate groups, stronger the binding, but a very limited specificity due to the 2-phosphate was also observed. Inositol 36-44 pleckstrin Homo sapiens 19-29 11671967-2 1997 Reactions of ortho esters of myo-inositol 8 or 10 with 1-2 equiv of Grignard reagents in benzene-ether yield regio- and stereoselectively the corresponding ring opening products having a free hydroxy group at C-1. Inositol 29-41 heterogeneous nuclear ribonucleoprotein C Homo sapiens 209-212 11671967-4 1997 Inositol derivatives having two free hydroxy group at C-1 and C-3 positions can be achieved from reactions of 6 or 8 with excess Grignard reagents or under more drastic conditions. Inositol 0-8 heterogeneous nuclear ribonucleoprotein C Homo sapiens 54-65 9409765-1 1997 We previously reported that the Saccharomyces cerevisiae ire15 mutation results in an inositol-auxotrophic phenotype, and that human cDNAs can suppress the ire15 mutation (Nikawa, J., 1994. Inositol 86-94 transcription factor HAC1 Saccharomyces cerevisiae S288C 57-62 9409765-8 1997 All human cDNAs and yeast multicopy suppressors, which had been isolated as suppressors for the ire15 mutation, were able to suppress the inositol-auxotrophic phenotype but not the defect in KAR2 induction of the hac1-disrupted strain. Inositol 138-146 transcription factor HAC1 Saccharomyces cerevisiae S288C 96-101 9367761-1 1997 The X-ray crystal structure of the phosphatidylinositol-specific phospholipase C (PI-PLC) from the human pathogen Listeria monocytogenes has been determined both in free form at 2.0 A resolution, and in complex with the competitive inhibitor myo-inositol at 2.6 A resolution. Inositol 242-254 phospholipase C beta 1 Homo sapiens 35-80 9367761-1 1997 The X-ray crystal structure of the phosphatidylinositol-specific phospholipase C (PI-PLC) from the human pathogen Listeria monocytogenes has been determined both in free form at 2.0 A resolution, and in complex with the competitive inhibitor myo-inositol at 2.6 A resolution. Inositol 242-254 phospholipase C beta 1 Homo sapiens 82-88 9370250-8 1997 On the assumption that the P/ODAG bond is orientated parallel to the bilayer normal, these results are consistent with two possible conformations for the portion of the headgroup connecting the diacylglycerol to the inositol ring. Inositol 216-224 GATA zinc finger domain containing 1 Homo sapiens 29-33 9326360-3 1997 The ACS2 upstream region contains an ICRE (inositol/choline-responsive element) as an activating sequence and requires the regulatory genes INO2 and INO4 for maximal expression. Inositol 43-51 acetate--CoA ligase ACS2 Saccharomyces cerevisiae S288C 4-8 9278475-2 1997 rpo26-31 also confers inositol auxotrophy, inhibits the assembly of RNAPI and RNAPII and reduces the steady-state level of Rpo26p and the largest subunit of RNAPI (Rpo11p or A190p) and RNAPII (Rpo21p). Inositol 22-30 DNA-directed RNA polymerase core subunit RPO26 Saccharomyces cerevisiae S288C 0-5 9370337-15 1997 The upstream regulatory region of the PSS/CHO1 gene responsible for the myo-inositol-choline regulation was identified. Inositol 72-84 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 42-46 9299172-1 1997 Hyperosmotic-induced enhancement of myo-inositol accumulation in cultured bovine lens epithelial cells stems from increased uptake activity due to upregulation of Na+/myo-inositol cotransporter mRNA and de novo synthesis in myo-inositol carrier protein. Inositol 36-48 sodium/myo-inositol cotransporter Bos taurus 163-193 9294443-9 1997 I report that the major mitochondrial PS decarboxylase gene (PSD1) is transcriptionally regulated by inositol in a manner similar to that reported for other coregulated phospholipid biosynthetic genes. Inositol 101-109 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 61-65 9294443-11 1997 In yeast, phosphatidylcholine (PC) biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol. Inositol 159-167 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 133-137 9294443-12 1997 I show that the presence of a functional major mitochondrial PS decarboxylase encoded by the PSD1 gene is necessary for proper regulation of INO1 in response to inositol in the absence of ethanolamine. Inositol 161-169 phosphatidylserine decarboxylase 1 Saccharomyces cerevisiae S288C 93-97 9294443-12 1997 I show that the presence of a functional major mitochondrial PS decarboxylase encoded by the PSD1 gene is necessary for proper regulation of INO1 in response to inositol in the absence of ethanolamine. Inositol 161-169 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 141-145 9377164-2 1997 The inositol derivative D-myo-inositol[1,2,6]triphosphate (alpha-trinositol) has been demonstrated to be a specific nonpeptide antagonist of vasoconstriction induced by neuropeptide Y. Inositol 4-12 pro-neuropeptide Y Ovis aries 169-183 9337881-4 1997 The hyperosmolarity-induced SMIT mRNA increase was counteracted by added myo-inositol or betaine. Inositol 73-85 solute carrier family 5 (inositol transporters), member 3 Mus musculus 28-32 9252414-6 1997 As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-). Inositol 130-138 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 45-50 9252414-6 1997 As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-). Inositol 130-138 bifunctional choline kinase/ethanolamine kinase CKI1 Saccharomyces cerevisiae S288C 55-59 9252414-6 1997 As phosphatidylcholine turnover increases in sec14(ts) cki1 cells shifted to the restrictive temperature, the INO1 gene (encoding inositol-1-phosphate synthase) is also derepressed, leading to an inositol excretion phenotype (Opi-). Inositol 130-138 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 110-114 9172386-4 1997 Myo-inositol, betaine and taurine are accumulated by increased activity of specific sodium-coupled transporters, sorbitol by increased synthesis of aldose reductase that catalyses the synthesis of sorbitol from glucose. Inositol 0-12 aldo-keto reductase family 1 member B Homo sapiens 148-164 9172386-6 1997 cDNAs for the cotransporters and for aldose reductase have been cloned and used to establish that hypertonicity increases the transcription of the genes for the cotransporters for myo-inositol, betaine and for aldose reductase. Inositol 180-192 aldo-keto reductase family 1 member B Homo sapiens 37-53 9172386-6 1997 cDNAs for the cotransporters and for aldose reductase have been cloned and used to establish that hypertonicity increases the transcription of the genes for the cotransporters for myo-inositol, betaine and for aldose reductase. Inositol 180-192 aldo-keto reductase family 1 member B Homo sapiens 210-226 9207861-5 1997 Based on studies suggesting that myo-inositol or a phosphorylated metabolite might act downstream from Bruton"s tyrosine kinase (Btk) in a signal transduction pathway in B cells, immunodeficient CBA/CaHN-XID/J mice were fed a standard diet or the same diet supplemented with 0.4% myo-inositol. Inositol 33-45 Bruton agammaglobulinemia tyrosine kinase Mus musculus 103-127 9207861-5 1997 Based on studies suggesting that myo-inositol or a phosphorylated metabolite might act downstream from Bruton"s tyrosine kinase (Btk) in a signal transduction pathway in B cells, immunodeficient CBA/CaHN-XID/J mice were fed a standard diet or the same diet supplemented with 0.4% myo-inositol. Inositol 33-45 Bruton agammaglobulinemia tyrosine kinase Mus musculus 129-132 9207861-5 1997 Based on studies suggesting that myo-inositol or a phosphorylated metabolite might act downstream from Bruton"s tyrosine kinase (Btk) in a signal transduction pathway in B cells, immunodeficient CBA/CaHN-XID/J mice were fed a standard diet or the same diet supplemented with 0.4% myo-inositol. Inositol 280-292 Bruton agammaglobulinemia tyrosine kinase Mus musculus 103-127 9207861-5 1997 Based on studies suggesting that myo-inositol or a phosphorylated metabolite might act downstream from Bruton"s tyrosine kinase (Btk) in a signal transduction pathway in B cells, immunodeficient CBA/CaHN-XID/J mice were fed a standard diet or the same diet supplemented with 0.4% myo-inositol. Inositol 280-292 Bruton agammaglobulinemia tyrosine kinase Mus musculus 129-132 9207861-7 1997 When rechallenged with SRBC, XID mice given supplemental inositol produced significantly more IgM antibody than did the XID and immunocompetent controls (3.6 +/- 0.5 vs 1.8 +/- 1.1 and 1.5 +/- 0.7, respectively). Inositol 57-65 Bruton agammaglobulinemia tyrosine kinase Mus musculus 29-32 9207861-9 1997 These results suggest that dietary myo-inositol or a derivative may be able to modulate B-cell IgM responses by interacting within the inositol second messenger system downstream from Bruton"s tyrosine kinase. Inositol 35-47 Bruton agammaglobulinemia tyrosine kinase Mus musculus 184-208 9207861-9 1997 These results suggest that dietary myo-inositol or a derivative may be able to modulate B-cell IgM responses by interacting within the inositol second messenger system downstream from Bruton"s tyrosine kinase. Inositol 39-47 Bruton agammaglobulinemia tyrosine kinase Mus musculus 184-208 9247119-2 1997 The first subroute is the inositol cycle as found in other organisms: inositol is incorporated into phospholipids that are hydrolysed by PLC producing Ins(1,4,5)P3 which is dephosphorylated to inositol. Inositol 26-34 heparan sulfate proteoglycan 2 Homo sapiens 137-140 9247119-2 1997 The first subroute is the inositol cycle as found in other organisms: inositol is incorporated into phospholipids that are hydrolysed by PLC producing Ins(1,4,5)P3 which is dephosphorylated to inositol. Inositol 70-78 heparan sulfate proteoglycan 2 Homo sapiens 137-140 9247119-2 1997 The first subroute is the inositol cycle as found in other organisms: inositol is incorporated into phospholipids that are hydrolysed by PLC producing Ins(1,4,5)P3 which is dephosphorylated to inositol. Inositol 70-78 heparan sulfate proteoglycan 2 Homo sapiens 137-140 9185625-3 1997 The chiro-inositol contents in several different GPI-anchored proteins including 5"-nucleotidase of bovine liver and alkaline phosphatase of mouse NS-1 varied with hydrolytic conditions of these GPI anchor. Inositol 10-18 5'-nucleotidase Bos taurus 81-96 9264311-4 1997 The increased phosphorylation of P-gp was accompanied by stimulation of PLC activity, as measured by the production of inositol, 1,4,5-trisphosphate and diacylglycerol, products of phosphatidylinositol-4,5-bisphosphate hydrolysis. Inositol 119-127 ATP binding cassette subfamily B member 1 Homo sapiens 33-37 9187110-1 1997 The nucleus has been shown to be a site for the inositol lipid cycle that can be affected by treatment of quiescent cells with growth factors such as insulin-like growth factor I (IGF-I). Inositol 48-56 insulin-like growth factor 1 Mus musculus 150-178 9187110-1 1997 The nucleus has been shown to be a site for the inositol lipid cycle that can be affected by treatment of quiescent cells with growth factors such as insulin-like growth factor I (IGF-I). Inositol 48-56 insulin-like growth factor 1 Mus musculus 180-185 9211788-0 1997 Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae. Inositol 85-93 Ino2p Saccharomyces cerevisiae S288C 68-72 9211788-0 1997 Influence of gene dosage and autoregulation of the regulatory genes INO2 and INO4 on inositol/choline-repressible gene transcription in the yeast Saccharomyces cerevisiae. Inositol 85-93 Ino4p Saccharomyces cerevisiae S288C 77-81 9211788-2 1997 ICRE-dependent gene activation, requiring the regulatory genes INO2 and INO4, is repressed in the presence of the phospholipid precursors inositol and choline. Inositol 138-146 Ino2p Saccharomyces cerevisiae S288C 63-67 9211788-2 1997 ICRE-dependent gene activation, requiring the regulatory genes INO2 and INO4, is repressed in the presence of the phospholipid precursors inositol and choline. Inositol 138-146 Ino4p Saccharomyces cerevisiae S288C 72-76 9211788-4 1997 However, an INO2 allele devoid of its ICRE functionally complemented an ino2 mutation and completely restored inositol/choline regulation of Ino2p-dependent reporter genes. Inositol 110-118 Ino2p Saccharomyces cerevisiae S288C 12-16 9232445-0 1997 Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell. Inositol 50-58 Fc gamma receptor Ia Homo sapiens 0-17 9154821-13 1997 ada1 mutants display defects similar to those of ada5 mutants and different from those of the other mutants with respect to promoters affected, inositol auxotrophy, and Spt- phenotypes. Inositol 144-152 transcriptional adaptor 1 Homo sapiens 0-4 9143369-1 1997 The sodium/myo-inositol cotransporter (SMIT) is a plasma membrane protein catalyzing transfer of myo-inositol into cells against a considerable concentration gradient using the electrochemical potential of sodium across the cell membrane. Inositol 11-23 LOC100856716 Canis lupus familiaris 39-43 9169052-6 1997 Activation of the wnt pathway with a dominant negative form of GSK-3 beta is inhibited by myo-inositol, similar to the previously described effect of coinjecting myo-inositol with lithium. Inositol 90-102 glycogen synthase kinase 3 beta L homeolog Xenopus laevis 63-73 9169052-6 1997 Activation of the wnt pathway with a dominant negative form of GSK-3 beta is inhibited by myo-inositol, similar to the previously described effect of coinjecting myo-inositol with lithium. Inositol 162-174 glycogen synthase kinase 3 beta L homeolog Xenopus laevis 63-73 9169052-7 1997 The mechanism by which myo-inositol inhibits both dominant negative GSK-3 beta and lithium remains uncertain. Inositol 23-35 glycogen synthase kinase 3 beta L homeolog Xenopus laevis 68-78 9171339-4 1997 Phosphoinositides with a phosphate at the D-3 position of the inositol ring, but not other isomers, also increase the affinity of the AP-2 complex for the tyrosine-based motif. Inositol 62-70 transcription factor AP-2 alpha Homo sapiens 134-138 9111022-7 1997 CDS1 expression is repressed in concert with INO2 expression in response to inositol. Inositol 76-84 phosphatidate cytidylyltransferase Saccharomyces cerevisiae S288C 0-4 9111022-7 1997 CDS1 expression is repressed in concert with INO2 expression in response to inositol. Inositol 76-84 Ino2p Saccharomyces cerevisiae S288C 45-49 9130251-4 1997 Incubation of [3H]-inositol pre-labeled Schwann cells with ET-1, ET-3 or sarafotoxin 6c elicited a concentration-dependent increase in the release of [P1 that reached a plateau at approximately 100 nM. Inositol 19-27 endothelin 1 Homo sapiens 59-63 9130251-4 1997 Incubation of [3H]-inositol pre-labeled Schwann cells with ET-1, ET-3 or sarafotoxin 6c elicited a concentration-dependent increase in the release of [P1 that reached a plateau at approximately 100 nM. Inositol 19-27 endothelin 3 Homo sapiens 65-69 9105768-3 1997 In addition, myoinositol (600 mumol/l) significantly depressed CD3, CD4 and HLA-DR antigen expression on PHA-activated PBMNC surface in chronic uremic patients and healthy subjects, while CD8 antigen expression remained unaffected. Inositol 13-24 CD4 molecule Homo sapiens 68-71 9218207-4 1997 In addition, they improve endothelium-dependent vasodilation by increasing the expression of endothelial inositol by a bradykinin-related mechanism. Inositol 105-113 kininogen 1 Homo sapiens 119-129 9013643-5 1997 Co-cross-linking sIg and the FcR enhanced the phosphorylation of the FcR, the adapter protein, Shc, and the inositol 5"-phosphatase Ship. Inositol 108-116 inositol polyphosphate-5-phosphatase D Homo sapiens 132-136 9003188-1 1997 Three inositol 1,2-(cyclic)-phosphate analogs, inositol cyclic phosphonates with different stereochemistry at the C-2 position of the inositol ring, have been synthesized as water-soluble inhibitors of phosphatidylinositol-specific phospholipase C (PI-PLC). Inositol 6-14 phospholipase C beta 1 Homo sapiens 202-247 9003188-4 1997 (i) Only the analog with the same stereochemistry at the C-2 position of the inositol ring as the natural substrate, myo-inositol 1,2-(cyclic)-phosphate (cIP), exhibits effective inhibition of PI-PLC. Inositol 77-85 phospholipase C beta 1 Homo sapiens 193-199 9030778-4 1997 We demonstrate here that axonin-1 released from dorsal root ganglion neurons contains ethanolamine and inositol, components of the glycosylPtdIns anchor. Inositol 103-111 contactin 2 Gallus gallus 25-33 8986742-3 1997 Inositol increases flux through the inositol/lipid cycle, stimulating protein kinase C activity and upregulating expression of retinoic acid receptor beta, specifically in the caudal portion of the embryonic hindgut. Inositol 0-8 retinoic acid receptor, beta Mus musculus 127-154 9016940-5 1996 Furthermore, rutaecarpine (40-200 microM) inhibited [3H]inositol monophosphate formation stimulated by collagen and thrombin in [3H]myoinositol-loaded platelets. Inositol 132-143 coagulation factor II, thrombin Homo sapiens 116-124 8973205-7 1996 Treatment of L1210A cell membranes with mild base rendered the protein PI-PLC sensitive as expected for GPI anchors acylated in the inositol ring and also decreased the affinities of the membrane associated FR for reduced folates. Inositol 132-140 protein disulfide isomerase associated 3 Mus musculus 71-77 8954925-0 1996 Polysulfated derivatives of beta-cyclodextrin and myo-inositol as potent inhibitors of the interaction between L-selectin and peripheral addressin: implying a requirement for highly clustered sulfate groups. Inositol 50-62 selectin L Homo sapiens 111-121 8954925-1 1996 We have utilized an in vitro assay that measures the binding of an L-selectin-human Fc chimera (LS-Fc) to [35S]sulfate labelled peripheral addressin (PNAd), a 120 kDa glycoprotein ligand for L-selectin in porcine lymph nodes, to evaluate inhibitory properties of a small group of sulfated derivatives of beta-cyclodextrin (beta-CD), sLe(x) and myo-inositol to their non-sulfated counterparts were studied. Inositol 344-356 selectin L Homo sapiens 67-77 8954925-1 1996 We have utilized an in vitro assay that measures the binding of an L-selectin-human Fc chimera (LS-Fc) to [35S]sulfate labelled peripheral addressin (PNAd), a 120 kDa glycoprotein ligand for L-selectin in porcine lymph nodes, to evaluate inhibitory properties of a small group of sulfated derivatives of beta-cyclodextrin (beta-CD), sLe(x) and myo-inositol to their non-sulfated counterparts were studied. Inositol 344-356 N-terminal asparagine amidase Homo sapiens 150-154 8955387-7 1996 The amino acid sequence of the glp repressor was similar to several repressors of carbohydrate catabolic systems, including those of the glucitol (GutR), fucose (FucR), and deoxyribonucleoside (DeoR) systems of E. coli, as well as those of the lactose (LacR) and inositol (IolR) systems of gram-positive bacteria and agrocinopine (AccR) system of Agrobacterium tumefaciens. Inositol 263-271 repressor Escherichia coli 35-44 8943075-1 1996 Capacitative Ca2+ entry is a component of the inositol-lipid signaling in which depletion of inositol 1,4,5-trisphosphate (InsP3)-sensitive Ca2+ stores activates Ca2+ influx by a mechanism that is still unknown. Inositol 46-54 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 123-128 8910557-4 1996 In this study we present evidence that the molecular basis for the inositol excretion phenotype is a G305/A305 point mutation (Cys102 --> Tyr substitution) within the CDS1 gene (encodes CDP-DAG synthase) of this mutant. Inositol 67-75 phosphatidate cytidylyltransferase Saccharomyces cerevisiae S288C 170-174 8910557-5 1996 Expression of CDP-DAG synthase activity from a plasmid-borne copy of the CDS1 gene in the cdg1 mutant was not down-regulated, and this expression also corrected the inositol excretion phenotype. Inositol 165-173 phosphatidate cytidylyltransferase Saccharomyces cerevisiae S288C 73-77 8910557-7 1996 Expression of CDS1* in a single copy in the cdg1 mutant raised CDP-DAG synthase activity from 15 to 30% of derepressed wild-type yeast levels but still did not correct the inositol excretion phenotype. Inositol 172-180 phosphatidate cytidylyltransferase Saccharomyces cerevisiae S288C 14-18 8910381-4 1996 The GPI1 gene, which encodes a 609-amino acid membrane protein, was cloned by complementation of the temperature sensitivity of gpi1 and corrects the mutant"s [3H]inositol labeling and enzymatic defects. Inositol 163-171 phosphatidylinositol N-acetylglucosaminyltransferase Saccharomyces cerevisiae S288C 4-8 8910381-4 1996 The GPI1 gene, which encodes a 609-amino acid membrane protein, was cloned by complementation of the temperature sensitivity of gpi1 and corrects the mutant"s [3H]inositol labeling and enzymatic defects. Inositol 163-171 phosphatidylinositol N-acetylglucosaminyltransferase Saccharomyces cerevisiae S288C 128-132 8910382-4 1996 We purified PLP as an inositol 1,3,4,5-tetrakisphosphate-binding protein after solubilization in a non-organic solvent. Inositol 22-30 proteolipid protein 1 Homo sapiens 12-15 8932376-2 1996 We have characterized a yeast gene, IRE2, which was isolated as a suppressor gene that complements the inositol auxotrophic phenotype of the ire1 mutation. Inositol 103-111 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 141-145 8932376-5 1996 ire2/hac1-disrupted yeast cells showed not only the inositol auxotrophic phenotype but also the tunicamycin sensitivity, and failed to induce the expression of KAR2. Inositol 52-60 transcription factor HAC1 Saccharomyces cerevisiae S288C 5-9 8932376-6 1996 These results clearly indicate that the IRE2/HAC1 gene product plays a critical role in the induction of KAR2 expression and in the inositol prototrophy mediated by IRE1. Inositol 132-140 transcription factor HAC1 Saccharomyces cerevisiae S288C 45-49 8932376-6 1996 These results clearly indicate that the IRE2/HAC1 gene product plays a critical role in the induction of KAR2 expression and in the inositol prototrophy mediated by IRE1. Inositol 132-140 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 165-169 8946442-2 1996 The present report describes the effects of another isomer of inositol, myoinositol, on postprandial plasma glucose and insulin concentrations and on urine glucose concentrations in 6 similarly insulin-resistant monkeys. Inositol 72-83 insulin Macaca mulatta 120-127 8946442-7 1996 The plasma insulin concentration was lower after the meal with myoinositol compared to the control meal at 150 and 180 min (p"s < 0.05). Inositol 63-74 insulin Macaca mulatta 11-18 8900132-3 1996 This is unusual because the amounts and/or activities of other phospholipid biosynthetic enzymes are affected by these precursors, and the promoter of the PIS1 gene contains a sequence resembling the regulatory element that coordinates the inositol-mediated regulation (UASINO). Inositol 240-248 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 155-159 8900132-4 1996 We found that transcription of the PIS1 gene was insensitive to inositol and choline and did not require the putative UASINO regulatory sequence or the cognate regulatory genes (INO2 and OPI1). Inositol 64-72 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 35-39 8900132-9 1996 Thus, PIS1 gene expression is unique among the phospholipid biosynthetic structural genes because it is uncoupled from the inositol response and regulated in response to the carbon source. Inositol 123-131 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Saccharomyces cerevisiae S288C 6-10 8810347-2 1996 In yeast, PC biosynthesis is required for the repression of the phospholipid biosynthetic genes, including the INO1 gene, in response to inositol. Inositol 137-145 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 111-115 8810347-4 1996 We report that repression of INO1 transcription in response to inositol is clearly dependent on ongoing PC biosynthesis, but it is independent of the route of synthesis. Inositol 63-71 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 29-33 8898018-9 1996 These results confirm and extend our studies of cultured glial cells and indicate that myo-inositol accumulation in vivo is due to increased expression of SMIT. Inositol 87-99 solute carrier family 5 member 3 Rattus norvegicus 155-159 8887991-3 1996 We investigate the hypothesis that the action of chronic lithium on PKC isozymes and substrates may be secondary to its potent effect in inhibiting the recycling of inositol. Inositol 165-173 protein kinase C, alpha Rattus norvegicus 68-71 8887991-5 1996 There was a significant interaction between chronic lithium and myo-inositol administration, with the chronic ICV administration of myo-inositol attenuating lithium"s effects on PKC alpha, PKC epsilon, and on pertussis toxin-catalyzed [32P]ADP-ribosylation. Inositol 132-144 protein kinase C, alpha Rattus norvegicus 178-187 8805618-4 1996 Since co-clustering of the BCR and Fc gamma RII also down-regulates proliferation induced by Ag receptor stimulation, we hypothesize that tyrosine phosphorylation of SHIP and its association with Shc contribute to negative signaling through effects on inositol and phosphatidylinositol metabolism. Inositol 252-260 inositol polyphosphate-5-phosphatase D Homo sapiens 166-170 8805618-4 1996 Since co-clustering of the BCR and Fc gamma RII also down-regulates proliferation induced by Ag receptor stimulation, we hypothesize that tyrosine phosphorylation of SHIP and its association with Shc contribute to negative signaling through effects on inositol and phosphatidylinositol metabolism. Inositol 252-260 SHC adaptor protein 1 Homo sapiens 196-199 8804431-1 1996 Phosphatidylinositol synthase (CDP-1,2-diacyl-sn-glycerol: 3-phosphatidyltransferase, EC 2.7.8.11) catalyzes the formation of phosphatidylinositol and CMP from CDP-diacylglycerol and myo-inositol. Inositol 183-195 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Rattus norvegicus 0-29 8804431-1 1996 Phosphatidylinositol synthase (CDP-1,2-diacyl-sn-glycerol: 3-phosphatidyltransferase, EC 2.7.8.11) catalyzes the formation of phosphatidylinositol and CMP from CDP-diacylglycerol and myo-inositol. Inositol 183-195 Ctr9p Saccharomyces cerevisiae S288C 31-36 9077435-7 1996 Cells lacking Ern4p are unable to induce transcription of any of the five target genes tested and exhibit sensitivity to ER stress and inositol requirement for growth. Inositol 135-143 transcription factor HAC1 Saccharomyces cerevisiae S288C 14-19 8764606-4 1996 The lithium-induced reduction in MARCKS is dependent on the concentration of inositol present in the medium and is reversed and prevented in the presence of elevated inositol concentrations. Inositol 77-85 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 33-39 8764606-4 1996 The lithium-induced reduction in MARCKS is dependent on the concentration of inositol present in the medium and is reversed and prevented in the presence of elevated inositol concentrations. Inositol 166-174 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 33-39 8657310-0 1996 Regulation by cAMP-dependent protein kinease of a G-protein-mediated phospholipase C. The heterotrimeric G proteins mediate a variety of cellular processes by coupling transmembrane receptors to different effector molecules, including adenylyl cyclases and inositol-phospholipid-specific phospholipase C (PLC)1-3. Inositol 257-265 phospholipase C gamma 1 Homo sapiens 305-312 8692861-9 1996 We conclude that (i) because the PI binding/transfer activities of PITP/SEC14p is the common feature shared by all three transfer proteins, it must be the relevant activity that determines their abilities to restore inositol lipid-mediated signaling and (ii) PITP is a general requirement for inositol lipid hydrolysis regardless of how and which isoform of PLC is activated by the appropriate agonist. Inositol 216-224 phosphatidylinositol/phosphatidylcholine transfer protein SEC14 Saccharomyces cerevisiae S288C 72-78 8810039-1 1996 In yeast, INO1 and CHO2 gene expression is subject to repression in response to inositol and choline supplementation. Inositol 80-88 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 10-14 8810039-1 1996 In yeast, INO1 and CHO2 gene expression is subject to repression in response to inositol and choline supplementation. Inositol 80-88 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 19-23 8662856-6 1996 Cpk has an intrinsic PtdIns kinase activity and can phosphorylate PtdIns and PtdIns-4-P, but not PtdIns(4,5)P2, at the D3 position of the inositol ring. Inositol 138-146 Phosphatidylinositol 3-kinase 68D Drosophila melanogaster 0-3 8764194-1 1996 The Ca2+/inositol phospholipid signaling cascade has been implicated in the mechanism by which cholecystokinin (CCK) stimulates gastric somatostatin release, but a direct linkage between intracellular events in gastric D cells and somatostatin secretion has not been established. Inositol 9-17 cholecystokinin Homo sapiens 95-110 8764194-1 1996 The Ca2+/inositol phospholipid signaling cascade has been implicated in the mechanism by which cholecystokinin (CCK) stimulates gastric somatostatin release, but a direct linkage between intracellular events in gastric D cells and somatostatin secretion has not been established. Inositol 9-17 cholecystokinin Homo sapiens 112-115 8725219-3 1996 We demonstrate that the basis for this Ino- phenotype is the inability of BSD2-1 strains to derepress transcription of INO1, the structural gene for the enzyme that catalyzes the committed step in de novo inositol biosynthesis in yeast. Inositol 205-213 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 119-123 8743477-11 1996 When cell betaine or inositol is increased by raising its concentration in the medium, GPC:PDE activity rises, reducing cell GPC. Inositol 21-29 aldehyde dehydrogenase 7 family member A1 Homo sapiens 91-94 8839441-0 1996 Dietary myo-inositol restores diabetic renal arteriolar reactivity to angiotensin II but not to norepinephrine. Inositol 8-20 angiotensinogen Rattus norvegicus 70-84 8839441-9 1996 RESULTS: Among diabetic rats, the myo-inositol-enriched diet significantly enhanced the constriction of interlobular, afferent, and efferent arterioles in response to Ang II, so that the responses to the peptide were almost completely restored to normal. Inositol 34-46 angiotensinogen Rattus norvegicus 167-173 8839441-13 1996 Diminished arteriolar constriction due to Ang II, but not to NE, may be linked to altered myo-inositol metabolism. Inositol 90-102 angiotensinogen Rattus norvegicus 42-48 8675017-1 1996 The Saccharomyces cerevisiae ire15 mutant has a defect in the expression of the IN01 gene, showing an inositol auxotrophic phenotype. Inositol 102-110 transcription factor HAC1 Saccharomyces cerevisiae S288C 29-34 8614637-2 1996 Derepression in response to inositol deprivation requires the INO2 and INO4 regulatory genes. Inositol 28-36 Ino2p Saccharomyces cerevisiae S288C 62-66 8614637-2 1996 Derepression in response to inositol deprivation requires the INO2 and INO4 regulatory genes. Inositol 28-36 Ino4p Saccharomyces cerevisiae S288C 71-75 8614637-3 1996 Repression in response to inositol supplementation requires the OPI1 regulatory gene. Inositol 26-34 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 64-68 8804157-2 1996 In the presence of thapsigargin, a Ca(2+)-ATPase inhibitor of inositol (1, 4, 5) triphosphate (InsP3)-sensitive Ca2+ stores, caffeine caused an increase in [Ca2+]i, which was inhibited by treatment with ryanodine (a ligand to the Ca(2+)-induced Ca2+ release channels). Inositol 62-70 carbonic anhydrase 2 Rattus norvegicus 112-115 8595962-11 1996 Inhibition of aldose reductase activity substantially diminished myo-inositol efflux from cell to galactose-containing, isotonic medium. Inositol 65-77 aldose reductase Bos taurus 14-30 8772575-3 1996 A novel low mol wt inositol phosphoglycan antagonist of insulin action of oxidative glucose metabolism in isolated rat adipocytes was partially purified from normal human plasma and shown to be increased in type II diabetic plasma. Inositol 19-27 insulin Homo sapiens 56-63 8609230-0 1996 Modulation of basal nitric oxide-dependent cyclic-GMP production by ambient glucose, myo-inositol, and protein kinase C in SH-SY5Y human neuroblastoma cells. Inositol 85-97 5'-nucleotidase, cytosolic II Homo sapiens 50-53 8598201-1 1996 Inositol starvation of auxotrophic yeast interrupts glycolipid biosynthesis and prevents lipid modification of a normally glycosyl phosphatidylinositol (GPI)-linked protein, Gas1p. Inositol 0-8 1,3-beta-glucanosyltransferase GAS1 Saccharomyces cerevisiae S288C 174-179 8546702-1 1996 We have reported that two inositol 1,4,5-trisphosphate binding proteins, with molecular masses of 85 and 130 kDa, were purified from rat brain; the former protein was found to be the delta 1-isoenzyme of phospholipase C (PLC-delta 1) and the latter was an unidentified novel protein [Kanematsu, Takeya, Watanabe, Ozaki, Yoshida, Koga, Iwanaga and Hirata (1992) J. Biol. Inositol 26-34 phospholipase C, delta 1 Rattus norvegicus 221-232 9213428-1 1996 The [(3)H]inositol incorporation into the membrane fraction of A-431 human epidermoid carcinoma cells was markedly increased by stimulation of the cells with either epidermal growth factor (EGF), ATP, bradykinin, or a calcium ionophore A23187 in the presence of 1 mM extracellular calcium ions; most incorporated [(3)H]inositol was found to have accumulated as phosphatidylinositol (PI). Inositol 10-18 kininogen 1 Homo sapiens 201-211 8970502-12 1996 The reduction in MARCKS produced by lithium was reversed by the addition of inositol to the media, whereas the reduction produced by valproate was unaffected by the addition of inositol. Inositol 76-84 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 17-23 8970502-15 1996 The MARCKS reduction produced by valproate appears to occur independently of inositol concentrations yet is additive with the reduction produced by lithium, which is inositol-reversible. Inositol 77-85 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 4-10 8970502-15 1996 The MARCKS reduction produced by valproate appears to occur independently of inositol concentrations yet is additive with the reduction produced by lithium, which is inositol-reversible. Inositol 166-174 myristoylated alanine rich protein kinase C substrate Rattus norvegicus 4-10 8551228-6 1996 The molecular basis for this interaction was further examined using a glycosyl phosphatidyl inositol (GPI)-linked form of CD45Null (lacking tyrosine phosphatase domains), which preferentially associated with CD4 compared with GPI-linked CD45ABC, and cytoplasmic tail mutants of CD4, which retained the ability to coassociate. Inositol 92-100 protein tyrosine phosphatase receptor type C Homo sapiens 122-126 8551228-6 1996 The molecular basis for this interaction was further examined using a glycosyl phosphatidyl inositol (GPI)-linked form of CD45Null (lacking tyrosine phosphatase domains), which preferentially associated with CD4 compared with GPI-linked CD45ABC, and cytoplasmic tail mutants of CD4, which retained the ability to coassociate. Inositol 92-100 CD4 molecule Homo sapiens 122-125 8551228-6 1996 The molecular basis for this interaction was further examined using a glycosyl phosphatidyl inositol (GPI)-linked form of CD45Null (lacking tyrosine phosphatase domains), which preferentially associated with CD4 compared with GPI-linked CD45ABC, and cytoplasmic tail mutants of CD4, which retained the ability to coassociate. Inositol 92-100 CD4 molecule Homo sapiens 208-211 9029413-2 1996 CSF inositol was reported to be reduced in depression and inositol has been reported to be effective in treatment of depression. Inositol 4-12 colony stimulating factor 2 Homo sapiens 0-3 8741841-8 1996 In addition, the level of the enzyme required for inositol biosynthesis, inositol-1-phosphate synthase, encoded by INO1, is not reduced in stationary-phase cells, and this contrast in the regulation of inositol supply is discussed. Inositol 50-58 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 115-119 8741841-8 1996 In addition, the level of the enzyme required for inositol biosynthesis, inositol-1-phosphate synthase, encoded by INO1, is not reduced in stationary-phase cells, and this contrast in the regulation of inositol supply is discussed. Inositol 73-81 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 115-119 7592954-9 1995 The subcellular localization of profilin was examined in vivo under growth conditions (i.e. inositol starvation of ino1 cells and glucose starvation of respiratory deficient cells) where plasma membrane levels of phosphatidylinositol 4,5-bisphosphate were depleted. Inositol 92-100 profilin Saccharomyces cerevisiae S288C 32-40 7485138-4 1995 The current study examined the effect of PTH-(1-84) on myoinositol turnover in vitro in rat brain synaptosomes. Inositol 55-66 parathyroid hormone Rattus norvegicus 41-50 7595517-7 1995 Comparison of the effects of agonist +/- Li+ on the concentrations of these cosubstrates for PtdIns synthase suggest that accelerated activity of this enzyme is differentially driven by stimulated increases in the amounts of CMP-phosphatidate or inositol in inositol-replete or depleted cells, respectively. Inositol 246-254 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 93-108 7595517-7 1995 Comparison of the effects of agonist +/- Li+ on the concentrations of these cosubstrates for PtdIns synthase suggest that accelerated activity of this enzyme is differentially driven by stimulated increases in the amounts of CMP-phosphatidate or inositol in inositol-replete or depleted cells, respectively. Inositol 258-266 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 93-108 7568205-2 1995 We have previously suggested that this response to inositol may be dictated by regulating transcription of the cognate activator gene, INO2. Inositol 51-59 Ino2p Saccharomyces cerevisiae S288C 135-139 7568205-3 1995 However, it was also known that cells which harbor a mutant opi1 allele express constitutively derepressed levels of target genes (INO1 and CHO1), implicating the OPI1 negative regulatory gene in the response to inositol. Inositol 212-220 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 60-64 7568205-3 1995 However, it was also known that cells which harbor a mutant opi1 allele express constitutively derepressed levels of target genes (INO1 and CHO1), implicating the OPI1 negative regulatory gene in the response to inositol. Inositol 212-220 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 131-135 7568205-3 1995 However, it was also known that cells which harbor a mutant opi1 allele express constitutively derepressed levels of target genes (INO1 and CHO1), implicating the OPI1 negative regulatory gene in the response to inositol. Inositol 212-220 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 140-144 7568205-3 1995 However, it was also known that cells which harbor a mutant opi1 allele express constitutively derepressed levels of target genes (INO1 and CHO1), implicating the OPI1 negative regulatory gene in the response to inositol. Inositol 212-220 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 163-167 7568205-4 1995 These observations suggested that the response to inositol may involve both regulation of INO2 transcription as well as OPI1-mediated repression. Inositol 50-58 Ino2p Saccharomyces cerevisiae S288C 90-94 7568205-4 1995 These observations suggested that the response to inositol may involve both regulation of INO2 transcription as well as OPI1-mediated repression. Inositol 50-58 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 120-124 7568205-5 1995 We investigated these possibilities by examining the effect of inositol on target gene expression in a strain containing the INO2 gene under control of the GAL1 promoter. Inositol 63-71 Ino2p Saccharomyces cerevisiae S288C 125-129 7568205-7 1995 The expression of the INO1 and CHO1 target genes was still responsive to inositol even though expression of the INO2 gene was unresponsive. Inositol 73-81 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 22-26 7568205-7 1995 The expression of the INO1 and CHO1 target genes was still responsive to inositol even though expression of the INO2 gene was unresponsive. Inositol 73-81 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 31-35 7568205-9 1995 Furthermore, the effect of inositol on target gene expression was eliminated by deleting the OPI1 gene in the GAL1-INO2-containing strain. Inositol 27-35 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 93-97 7568205-9 1995 Furthermore, the effect of inositol on target gene expression was eliminated by deleting the OPI1 gene in the GAL1-INO2-containing strain. Inositol 27-35 galactokinase Saccharomyces cerevisiae S288C 110-114 7568205-9 1995 Furthermore, the effect of inositol on target gene expression was eliminated by deleting the OPI1 gene in the GAL1-INO2-containing strain. Inositol 27-35 Ino2p Saccharomyces cerevisiae S288C 115-119 7568205-10 1995 These data suggest that the OPI1 gene product is the primary target (sensor) of the inositol response and that derepression of INO2 transcription determines the degree of expression of the target genes. Inositol 84-92 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 28-32 7559794-6 1995 Each of the mitogens lithium, 17 beta-estradiol, and EGF increased the rate of uptake of myo-inositol into MCF-7 cells. Inositol 89-101 epidermal growth factor Homo sapiens 53-56 7560072-6 1995 MCs transduced with the human GLUT1 gene (MCGT1) grown in 8 mM glucose had a 10-fold greater GLUT1 protein expression and a 1.9, 2.1, and 2.5-fold increase in cell myo-inositol, lactate production, and cell sorbitol content, respectively, as compared to control MCs transduced with bacterial beta-galactosidase (MCLacZ). Inositol 164-176 solute carrier family 2 member 1 Homo sapiens 30-35 7657791-1 1995 myo-inositol, a major compatible osmolyte in renal medulla, is accumulated in several kinds of cells under hypertonic conditions via Na+/myo-inositol cotransporter (SMIT). Inositol 0-12 solute carrier family 5 member 3 Rattus norvegicus 165-169 8588976-5 1995 In [3H]inositol-labelled cells, bradykinin evoked a rapid increase in inositol phosphates which preceded the increase in [3H]PtdBut formation. Inositol 7-15 kininogen 1 Homo sapiens 32-42 7629237-3 1995 A novel low mol wt inositol phosphoglycan inhibitor (M tau 1200-1500) of insulin action in rat adipocytes has been partially purified from normal human plasma. Inositol 19-27 insulin Homo sapiens 73-80 7626034-0 1995 Regulation of myo-inositol transport during the growth and differentiation of thyrocytes: a link with thyroid-stimulating hormone-induced phospholipase A2 activity. Inositol 14-26 phospholipase A2 group IB Homo sapiens 138-154 7626034-7 1995 In TSH-treated cells, however, up-regulation of myo-inositol transport was linked with increased myo-inositol cycling across the cell membrane, increased phospholipase A2-mediated turnover of phosphatidylinositol and a concomitant increase in arachidonic acid turnover. Inositol 48-60 phospholipase A2 group IB Homo sapiens 154-170 7583124-1 1995 BACKGROUND: Phosphatidylinositol transfer protein (PI-TP), which has the ability to transfer phosphatidylinositol (PI) from one membrane compartment to another, is required in the inositol lipid signalling pathway through phospholipase C-beta (PLC-beta) that is regulated by GTP-binding protein(s) in response to extracellular signals. Inositol 24-32 heparan sulfate proteoglycan 2 Homo sapiens 244-247 8537323-0 1995 Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae. Inositol 94-102 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 28-32 8537323-0 1995 Cloning and sequence of the SCS2 gene, which can suppress the defect of INO1 expression in an inositol auxotrophic mutant of Saccharomyces cerevisiae. Inositol 94-102 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 72-76 8537323-1 1995 Saccharomyces cerevisiae ire15 mutant has a defect in the expression of INO1, showing the inositol auxotrophic phenotype [Nikawa, J. Inositol 90-98 transcription factor HAC1 Saccharomyces cerevisiae S288C 25-30 8537323-1 1995 Saccharomyces cerevisiae ire15 mutant has a defect in the expression of INO1, showing the inositol auxotrophic phenotype [Nikawa, J. Inositol 90-98 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 72-76 7768846-5 1995 In a strain in which a negative regulator of phospholipid and inositol biosynthesis had been deleted (an opi1 mutant), this pattern of extracellular GroPIns accumulation in response to inositol availability was altered. Inositol 62-70 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 105-109 7768846-5 1995 In a strain in which a negative regulator of phospholipid and inositol biosynthesis had been deleted (an opi1 mutant), this pattern of extracellular GroPIns accumulation in response to inositol availability was altered. Inositol 185-193 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 105-109 7768846-6 1995 An inositol permease mutant (itr1 itr2), which is unable to transport free inositol, was able to incorporate label from exogenous glycerophospho [3H]inositol, indicating that the inositol label did not enter the cell solely via the transporters encoded by itr1 and itr2. Inositol 3-11 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 29-33 7768846-6 1995 An inositol permease mutant (itr1 itr2), which is unable to transport free inositol, was able to incorporate label from exogenous glycerophospho [3H]inositol, indicating that the inositol label did not enter the cell solely via the transporters encoded by itr1 and itr2. Inositol 3-11 myo-inositol transporter ITR2 Saccharomyces cerevisiae S288C 34-38 7768846-6 1995 An inositol permease mutant (itr1 itr2), which is unable to transport free inositol, was able to incorporate label from exogenous glycerophospho [3H]inositol, indicating that the inositol label did not enter the cell solely via the transporters encoded by itr1 and itr2. Inositol 3-11 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 256-260 7768846-6 1995 An inositol permease mutant (itr1 itr2), which is unable to transport free inositol, was able to incorporate label from exogenous glycerophospho [3H]inositol, indicating that the inositol label did not enter the cell solely via the transporters encoded by itr1 and itr2. Inositol 3-11 myo-inositol transporter ITR2 Saccharomyces cerevisiae S288C 265-269 7768846-6 1995 An inositol permease mutant (itr1 itr2), which is unable to transport free inositol, was able to incorporate label from exogenous glycerophospho [3H]inositol, indicating that the inositol label did not enter the cell solely via the transporters encoded by itr1 and itr2. Inositol 75-83 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 29-33 7603461-11 1995 Gluc(2,3",4")P3, with its alpha-glucoside ring, is the first synthetic Ins(1,4,5)P3 analogue that is not structurally based on a phosphorylated inositol isomer and that exhibits potent activity at the Ins(1,4,5)P3R. Inositol 144-152 glucosylceramidase beta 3 (gene/pseudogene) Homo sapiens 0-4 7726322-1 1995 OBJECTIVE: CSF levels of inositol have been reported to be lower than normal in depressed subjects. Inositol 25-33 colony stimulating factor 2 Homo sapiens 11-14 8527305-1 1995 PI 3-kinase, an enzyme that selectively phosphorylates the 3-position of the inositol ring, is acutely activated by insulin and other growth factors. Inositol 77-85 WAP four-disulfide core domain 15B Rattus norvegicus 0-4 7750541-1 1995 The heterotrimeric G-protein alpha-chain G alpha q plays a critical role mediating receptor-linked activation of the beta isoforms of PLC which hydrolyse membrane inositol-containing phospholipids to generate the second messengers inositol 1,4,5-trisphosphate and diacylglycerol. Inositol 163-171 G protein subunit alpha q Homo sapiens 41-50 7630147-5 1995 We conclude that selected inositol derivatives may inhibit the vasopressor effects to NPY in vitro and in vivo. Inositol 26-34 neuropeptide Y Rattus norvegicus 86-89 7752919-4 1995 Aldose reductase inhibitors are thought to have an effect by decreasing peripheral nerve sorbitol content and increasing nerve myo-inositol. Inositol 127-139 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 7753636-3 1995 INO1-100 suppressed the inositol auxotrophy of ino2, ino4, swi1, swi2 and swi3 mutants. Inositol 24-32 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 0-4 7753636-3 1995 INO1-100 suppressed the inositol auxotrophy of ino2, ino4, swi1, swi2 and swi3 mutants. Inositol 24-32 Ino2p Saccharomyces cerevisiae S288C 47-51 7753636-3 1995 INO1-100 suppressed the inositol auxotrophy of ino2, ino4, swi1, swi2 and swi3 mutants. Inositol 24-32 Ino4p Saccharomyces cerevisiae S288C 53-57 7753636-3 1995 INO1-100 suppressed the inositol auxotrophy of ino2, ino4, swi1, swi2 and swi3 mutants. Inositol 24-32 Swi1p Saccharomyces cerevisiae S288C 59-63 7753636-3 1995 INO1-100 suppressed the inositol auxotrophy of ino2, ino4, swi1, swi2 and swi3 mutants. Inositol 24-32 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 65-69 7753636-3 1995 INO1-100 suppressed the inositol auxotrophy of ino2, ino4, swi1, swi2 and swi3 mutants. Inositol 24-32 Swi3p Saccharomyces cerevisiae S288C 74-78 7753636-6 1995 A 38 bp deletion from -245 to -208 suppressed the inositol auxotrophy of an ino2 mutant, but not an ino4 mutant, indicating that Ino2p and Ino4p may function alone as well as in a complex. Inositol 50-58 Ino2p Saccharomyces cerevisiae S288C 76-80 7753636-6 1995 A 38 bp deletion from -245 to -208 suppressed the inositol auxotrophy of an ino2 mutant, but not an ino4 mutant, indicating that Ino2p and Ino4p may function alone as well as in a complex. Inositol 50-58 Ino2p Saccharomyces cerevisiae S288C 129-134 7753636-6 1995 A 38 bp deletion from -245 to -208 suppressed the inositol auxotrophy of an ino2 mutant, but not an ino4 mutant, indicating that Ino2p and Ino4p may function alone as well as in a complex. Inositol 50-58 Ino4p Saccharomyces cerevisiae S288C 139-144 7753636-8 1995 A deletion from -167 to -128 suppressed the inositol auxotrophy of swi, ino2 and ino4 mutants, indicating the presence of a previously unidentified URS1. Inositol 44-52 Ino2p Saccharomyces cerevisiae S288C 72-76 7753636-8 1995 A deletion from -167 to -128 suppressed the inositol auxotrophy of swi, ino2 and ino4 mutants, indicating the presence of a previously unidentified URS1. Inositol 44-52 Ino4p Saccharomyces cerevisiae S288C 81-85 7753636-9 1995 Mutation of the specific negative regulator of phospholipid synthesis encoded by OPI1 suppressed the inositol auxotrophy of swi2 mutants. Inositol 101-109 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 81-85 7753636-9 1995 Mutation of the specific negative regulator of phospholipid synthesis encoded by OPI1 suppressed the inositol auxotrophy of swi2 mutants. Inositol 101-109 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 124-128 7753636-10 1995 This study indicates that negative regulation of INO1 is chromatin mediated and provides in vivo information on the interaction of both general and specific regulatory factors that function to accomplish negative and positive regulation of the INO1 promoter in response to inositol. Inositol 273-281 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 49-53 7753636-10 1995 This study indicates that negative regulation of INO1 is chromatin mediated and provides in vivo information on the interaction of both general and specific regulatory factors that function to accomplish negative and positive regulation of the INO1 promoter in response to inositol. Inositol 273-281 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 244-248 7565092-1 1995 The expression of many genes of Saccharomyces cerevisiae, such as ITR1, is regulated by inositol and choline. Inositol 88-96 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 66-70 7565092-3 1995 Using this strain, three genes were isolated which, when introduced as multicopies, abolish the repression caused by inositol via the ITR1 promoter. Inositol 117-125 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 134-138 7890742-9 1995 Tandem mass spectrometric studies indicated that the palmitoyl residue of the CD52-II anchor is attached to the 2-position of the myo-inositol ring. Inositol 130-142 CD52 molecule Homo sapiens 78-82 7862162-2 1995 In the absence of inositol and choline (derepressing), the products of the INO2 and INO4 genes form a heteromeric complex which binds to a 10-bp element, upstream activation sequence INO (UASINO), in the promoters of the phospholipid biosynthetic genes to activate their transcription. Inositol 18-26 Ino2p Saccharomyces cerevisiae S288C 75-79 7862162-2 1995 In the absence of inositol and choline (derepressing), the products of the INO2 and INO4 genes form a heteromeric complex which binds to a 10-bp element, upstream activation sequence INO (UASINO), in the promoters of the phospholipid biosynthetic genes to activate their transcription. Inositol 18-26 Ino4p Saccharomyces cerevisiae S288C 84-88 7862162-3 1995 In the presence of inositol and choline (repressing), the product of the OPI1 gene represses transcription dictated by the UASINO element. Inositol 19-27 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 73-77 7862162-6 1995 Using a cat reporter gene, we find that INO2-cat expression was regulated 12-fold in response to inositol and choline but that INO4-cat was constitutively expressed. Inositol 97-105 Ino2p Saccharomyces cerevisiae S288C 40-44 7617297-4 1995 Moreover, as demonstrated in [3H]inositol labelled cells, treatment with thyrotropin releasing hormone (TRH) elicited the cleavage of [3H]GPtdIns in a similar manner, and this effect was followed by the phosphoinositide (PtdIns, PtdInsP and PtdInsP2) hydrolysis 30 s later. Inositol 33-41 thyrotropin releasing hormone Homo sapiens 73-102 7852314-1 1995 Uptake of inositol by Saccharomyces cerevisiae is mediated by a specific inositol permease encoded by the ITR1 gene. Inositol 10-18 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 106-110 7852314-2 1995 Removal of inositol from the growth medium results in an increase in ITR1 mRNA abundance. Inositol 11-19 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 69-73 7852314-4 1995 When inositol is added to the growth medium inactivation of uptake activity occurs, and both transcription of ITR1 and uptake activity are repressed to a basal level of function. Inositol 5-13 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 110-114 7852314-7 1995 In this study, we show that there is a change in the stability of the Itr1 permease after the addition of inositol to the growth medium. Inositol 106-114 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 70-74 7852314-8 1995 Immunoblot analysis using a monoclonal antibody against an epitope attached to the Itr1 permease showed that the addition of inositol causes a dramatic increase in the rate of degradation of the permease. Inositol 125-133 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 83-87 7896081-1 1995 The PIS gene for an enzyme phosphatidylinositol synthase having an increased Km for myo-inositol, was isolated from Saccharomyces cerevisiae. Inositol 84-96 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 4-7 7529770-1 1995 In Xenopus oocytes injected with total rat pituitary GH3 cell RNA, thyrotropin-releasing hormone (TRH) causes the activation of the inositol lipid transduction pathway and the induction of chloride conductance via calcium-activated channels (Oron et al., 1987, Mol. Inositol 132-140 thyrotropin releasing hormone Rattus norvegicus 67-96 7529770-1 1995 In Xenopus oocytes injected with total rat pituitary GH3 cell RNA, thyrotropin-releasing hormone (TRH) causes the activation of the inositol lipid transduction pathway and the induction of chloride conductance via calcium-activated channels (Oron et al., 1987, Mol. Inositol 132-140 thyrotropin releasing hormone Rattus norvegicus 98-101 7608126-1 1995 Genes involved in the phospholipid synthesis of Saccharomyces cerevisiae, such as PEM1, PEM2, PSS, and INO1, are coordinately repressed by myo-inositol and choline. Inositol 139-151 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 82-86 7608126-1 1995 Genes involved in the phospholipid synthesis of Saccharomyces cerevisiae, such as PEM1, PEM2, PSS, and INO1, are coordinately repressed by myo-inositol and choline. Inositol 139-151 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 88-92 7608126-1 1995 Genes involved in the phospholipid synthesis of Saccharomyces cerevisiae, such as PEM1, PEM2, PSS, and INO1, are coordinately repressed by myo-inositol and choline. Inositol 139-151 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 103-107 7608126-2 1995 In order to investigate this regulation, we transformed wild-type yeast with a PEM1 promoter-lacZ fusion and isolated two mutants, named ric1 and ric2 (regulation by myo-inositol and choline), exhibiting decreased PEM1 expression. Inositol 166-178 Ric1p Saccharomyces cerevisiae S288C 137-141 7608126-2 1995 In order to investigate this regulation, we transformed wild-type yeast with a PEM1 promoter-lacZ fusion and isolated two mutants, named ric1 and ric2 (regulation by myo-inositol and choline), exhibiting decreased PEM1 expression. Inositol 166-178 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 214-218 7608126-4 1995 ric1 mutant was auxotrophic for myo-inositol, indicating that INO1 expression was also affected, whereas ric2 mutant required myo-inositol only in the presence of choline. Inositol 32-44 Ric1p Saccharomyces cerevisiae S288C 0-4 7608126-4 1995 ric1 mutant was auxotrophic for myo-inositol, indicating that INO1 expression was also affected, whereas ric2 mutant required myo-inositol only in the presence of choline. Inositol 126-138 Ric1p Saccharomyces cerevisiae S288C 0-4 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 173-177 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 179-183 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 199-203 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 235-239 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 240-244 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 245-249 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 250-254 7608126-7 1995 Analysis using various lacZ fusion constructs containing promoters for genes in phospholipid synthesis revealed that the expression of myo-inositol-choline-regulated genes, PEM1, PEM2, PSS, CKI, and INO1, was markedly decreased in the snf2/swi2/gam1/tye3/ric1 background, but the expression of a constitutive gene, PIS, was not. Inositol 135-147 Ric1p Saccharomyces cerevisiae S288C 255-259 7608126-8 1995 We conclude that SNF2/SWI2/GAM1/TYE3/RIC1 is a positive regulatory gene required for the expression of not only INO1 gene, but also of myo-inositol-choline-regulated genes in general. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 17-21 7608126-8 1995 We conclude that SNF2/SWI2/GAM1/TYE3/RIC1 is a positive regulatory gene required for the expression of not only INO1 gene, but also of myo-inositol-choline-regulated genes in general. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 22-26 7608126-8 1995 We conclude that SNF2/SWI2/GAM1/TYE3/RIC1 is a positive regulatory gene required for the expression of not only INO1 gene, but also of myo-inositol-choline-regulated genes in general. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 27-31 7608126-8 1995 We conclude that SNF2/SWI2/GAM1/TYE3/RIC1 is a positive regulatory gene required for the expression of not only INO1 gene, but also of myo-inositol-choline-regulated genes in general. Inositol 135-147 SWI/SNF catalytic subunit SNF2 Saccharomyces cerevisiae S288C 32-36 7608126-8 1995 We conclude that SNF2/SWI2/GAM1/TYE3/RIC1 is a positive regulatory gene required for the expression of not only INO1 gene, but also of myo-inositol-choline-regulated genes in general. Inositol 135-147 Ric1p Saccharomyces cerevisiae S288C 37-41 7608126-8 1995 We conclude that SNF2/SWI2/GAM1/TYE3/RIC1 is a positive regulatory gene required for the expression of not only INO1 gene, but also of myo-inositol-choline-regulated genes in general. Inositol 135-147 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 112-116 7862526-0 1995 Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Inositol 117-125 Ino2p Saccharomyces cerevisiae S288C 32-36 7862526-0 1995 Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Inositol 117-125 Ino2p Saccharomyces cerevisiae S288C 53-58 7862526-0 1995 Yeast transcriptional activator INO2 interacts as an Ino2p/Ino4p basic helix-loop-helix heteromeric complex with the inositol/choline-responsive element necessary for expression of phospholipid biosynthetic genes in Saccharomyces cerevisiae. Inositol 117-125 Ino4p Saccharomyces cerevisiae S288C 59-64 7537337-9 1995 For oocytes expressing SGLT1, the sugar selectivity was: D-glucose, alpha-methyl-D-glucopyranoside, D-galactose, D-fucose, 3-O-methyl-D-glucose > D-xylose, L-xylose, 2-deoxy-D-glucose > myo-inositol, L-glucose, L-fucose. Inositol 192-204 solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog Xenopus laevis 23-28 7537337-10 1995 The ability of SMIT to transport glucose and SGLT1 to transport myo-inositol was independently confirmed by monitoring the Na(+)-dependent uptake of 3H-D-glucose and 3H-myo-inositol, respectively. Inositol 64-76 solute carrier family 5 member 3 S homeolog Xenopus laevis 15-19 7537337-10 1995 The ability of SMIT to transport glucose and SGLT1 to transport myo-inositol was independently confirmed by monitoring the Na(+)-dependent uptake of 3H-D-glucose and 3H-myo-inositol, respectively. Inositol 64-76 solute carrier family 5 (sodium/glucose cotransporter), member 1, gene 2 L homeolog Xenopus laevis 45-50 7707287-1 1995 The role of oestradiol in the control of uterine responsiveness to oxytocin was investigated by measuring oxytocin-induced phospholipase C activation in [3H]inositol-labelled cultured human myometrial cells. Inositol 157-165 oxytocin/neurophysin I prepropeptide Homo sapiens 67-75 7707287-1 1995 The role of oestradiol in the control of uterine responsiveness to oxytocin was investigated by measuring oxytocin-induced phospholipase C activation in [3H]inositol-labelled cultured human myometrial cells. Inositol 157-165 oxytocin/neurophysin I prepropeptide Homo sapiens 106-114 7623608-1 1995 The effects of elevated glucose and eicosapentaenoic acid (EPA, C20:5 omega 3) on myo-inositol uptake in human skin fibroblasts (HSF) were evaluated. Inositol 82-94 interleukin 6 Homo sapiens 129-132 7623608-2 1995 Myo-inositol incorporation into HSF was dependent on an active transport system via Na(+)-K+ ATPase activity based on the results with Na+ deprivation and ouabain (5 mM). Inositol 0-12 interleukin 6 Homo sapiens 32-35 7830715-2 1994 We now show that a sin3 mutation also partially suppresses the effects of swi1 on HO transcription, and partially suppresses the growth defect and inositol requirement observed in swi1 mutants. Inositol 147-155 transcriptional regulator SIN3 Saccharomyces cerevisiae S288C 19-23 7830715-2 1994 We now show that a sin3 mutation also partially suppresses the effects of swi1 on HO transcription, and partially suppresses the growth defect and inositol requirement observed in swi1 mutants. Inositol 147-155 Swi1p Saccharomyces cerevisiae S288C 180-184 7882818-0 1994 Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes. Inositol 8-22 insulin Homo sapiens 55-62 7882818-1 1994 OBJECTIVE: To determine the relationship between urinary chiro-inositol excretion and insulin sensitivity in Japanese type II diabetic patients. Inositol 57-71 insulin Homo sapiens 86-93 7894259-0 1994 CSF inositol in schizophrenia and high-dose inositol treatment of schizophrenia. Inositol 4-12 colony stimulating factor 2 Homo sapiens 0-3 7706223-1 1994 The SCS3 gene of Saccharomyces cerevisiae was cloned by functional complementation, using a conditional mutant exhibiting myo-inositol auxotrophy in the presence of choline, and sequenced. Inositol 122-134 Scs3p Saccharomyces cerevisiae S288C 4-8 7706223-3 1994 Disruption of the SCS3 locus caused myo-inositol auxotrophy. Inositol 36-48 Scs3p Saccharomyces cerevisiae S288C 18-22 7961831-2 1994 Incorporation of 32Pi into phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine in wild type and ept1 strains was decreased in the presence of exogenous inositol. Inositol 170-178 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 114-118 7961831-4 1994 In membranes isolated from wild type and ept1 strains grown in the presence of inositol or inositol/choline, the CPT1-derived cholinephosphotransferase activities were reduced 40-50 and 65%, respectively. Inositol 79-87 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 41-45 7961831-4 1994 In membranes isolated from wild type and ept1 strains grown in the presence of inositol or inositol/choline, the CPT1-derived cholinephosphotransferase activities were reduced 40-50 and 65%, respectively. Inositol 79-87 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 113-117 7961831-4 1994 In membranes isolated from wild type and ept1 strains grown in the presence of inositol or inositol/choline, the CPT1-derived cholinephosphotransferase activities were reduced 40-50 and 65%, respectively. Inositol 91-99 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 41-45 7961831-4 1994 In membranes isolated from wild type and ept1 strains grown in the presence of inositol or inositol/choline, the CPT1-derived cholinephosphotransferase activities were reduced 40-50 and 65%, respectively. Inositol 91-99 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 113-117 7961831-5 1994 Inositol-dependent reductions in CPT1 derived choline-phosphotransferase activity correlated with transcript levels in both wild type and ept- backgrounds. Inositol 0-8 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 33-37 7961831-6 1994 The ethanolaminephosphotransferase activity of the EPT1 gene product in wild type cells was reduced 40% by exogenous inositol alone and 50% by inositol/choline. Inositol 117-125 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 51-55 7961831-6 1994 The ethanolaminephosphotransferase activity of the EPT1 gene product in wild type cells was reduced 40% by exogenous inositol alone and 50% by inositol/choline. Inositol 143-151 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 51-55 7961831-8 1994 The inositol-dependent reduction of ethanolaminephosphotransferase activity observed in wild type cells correlated with reduced levels of EPT1 transcripts; in the cpt1 strain, EPT1 transcript levels were not affected by inositol. Inositol 4-12 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 138-142 7961831-8 1994 The inositol-dependent reduction of ethanolaminephosphotransferase activity observed in wild type cells correlated with reduced levels of EPT1 transcripts; in the cpt1 strain, EPT1 transcript levels were not affected by inositol. Inositol 4-12 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 163-167 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 86-94 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 44-48 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 86-94 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 86-94 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 189-193 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 86-94 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 44-48 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 189-193 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 44-48 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 189-193 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 44-48 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 189-193 7961831-9 1994 These results indicate that 1) a functional CPT1 gene or gene product is required for inositol-dependent regulation of phospholipid synthesis; 2) the enzyme activities of both the CPT1 and EPT1 gene products are repressed by inositol and inositol/choline, and require an intact CPT1 gene; 3) inositol mediates its regulatory effects on phospholipid synthesis via a transcriptional mechanism. Inositol 225-233 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 180-184 7961735-9 1994 Analysis of phospholipids extracted from wild type, cpt-, and ept- cells labeled with 32Pi indicated an intact CPT1 gene product was required for the pleiotropic regulation of phospholipid synthesis by inositol. Inositol 202-210 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 111-115 7961735-10 1994 Chimeric CPT1/EPT1 enzymes expressed in a cpt- background mapped the regulatory region of the CPT1 gene product required for the inositol-dependent regulation of phospholipid synthesis to the CDP-aminoalcohol binding domain of CPT1. Inositol 129-137 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 9-13 7961735-10 1994 Chimeric CPT1/EPT1 enzymes expressed in a cpt- background mapped the regulatory region of the CPT1 gene product required for the inositol-dependent regulation of phospholipid synthesis to the CDP-aminoalcohol binding domain of CPT1. Inositol 129-137 bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase Saccharomyces cerevisiae S288C 14-18 7961735-10 1994 Chimeric CPT1/EPT1 enzymes expressed in a cpt- background mapped the regulatory region of the CPT1 gene product required for the inositol-dependent regulation of phospholipid synthesis to the CDP-aminoalcohol binding domain of CPT1. Inositol 129-137 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 94-98 7961735-10 1994 Chimeric CPT1/EPT1 enzymes expressed in a cpt- background mapped the regulatory region of the CPT1 gene product required for the inositol-dependent regulation of phospholipid synthesis to the CDP-aminoalcohol binding domain of CPT1. Inositol 129-137 diacylglycerol cholinephosphotransferase Saccharomyces cerevisiae S288C 94-98 7918436-1 1994 cAMP-binding ectoprotein (Gce1) and lipoprotein lipase (LPL) are anchored to plasma membranes of rat adipocytes by glycosylphosphatidylinositol (GPI) moieties as demonstrated by cleavage by bacterial phosphatidylinositol-specific phospholipase C (PI-PLC), reactivity with anti-crossreacting determinant antibodies (anti-CRD), and metabolic labeling with radiolabeled palmitic acid and myo-inositol. Inositol 385-397 lipoprotein lipase Rattus norvegicus 36-54 7918436-1 1994 cAMP-binding ectoprotein (Gce1) and lipoprotein lipase (LPL) are anchored to plasma membranes of rat adipocytes by glycosylphosphatidylinositol (GPI) moieties as demonstrated by cleavage by bacterial phosphatidylinositol-specific phospholipase C (PI-PLC), reactivity with anti-crossreacting determinant antibodies (anti-CRD), and metabolic labeling with radiolabeled palmitic acid and myo-inositol. Inositol 385-397 lipoprotein lipase Rattus norvegicus 56-59 7524480-1 1994 The thyrotropin-releasing-hormone receptor (TRH-R) is a member of a family of the G-protein-coupled receptors that share structural similarities and exert their physiological action via the inositol lipid signal-transduction pathway. Inositol 190-198 thyrotropin releasing hormone receptor Mus musculus 4-42 7524480-1 1994 The thyrotropin-releasing-hormone receptor (TRH-R) is a member of a family of the G-protein-coupled receptors that share structural similarities and exert their physiological action via the inositol lipid signal-transduction pathway. Inositol 190-198 thyrotropin releasing hormone receptor Mus musculus 44-49 7925441-3 1994 A deletion analysis of the FAS1 promoter lacking the previously characterized inositol/choline-responsive-element motif defined a region (nucleotides -760 to -850) responsible for most of the remaining activation potency. Inositol 78-86 tetrafunctional fatty acid synthase subunit FAS1 Saccharomyces cerevisiae S288C 27-31 8089134-8 1994 The ability of the polyphosphoinositide phosphatase to hydrolyze phosphate from the 3-, 4-, or 5-position of the inositol ring suggests that this enzyme may play a key role in maintaining homeostasis among all forms of polyphosphoinositides. Inositol 113-121 FIG4 phosphoinositide 5-phosphatase Rattus norvegicus 19-51 7945204-6 1994 These results implicate an activation of the inositol lipid signalling pathway via the AT1 receptor subtype in the AII-stimulated mitogenic response of this normal epithelial cell line. Inositol 45-53 angiotensin II receptor, type 1a Rattus norvegicus 87-90 7945204-6 1994 These results implicate an activation of the inositol lipid signalling pathway via the AT1 receptor subtype in the AII-stimulated mitogenic response of this normal epithelial cell line. Inositol 45-53 angiotensinogen Rattus norvegicus 115-118 7894528-5 1994 They also indicate a possible role for the inositol second messenger system in the regulation of 5-HT2A receptors. Inositol 43-51 5-hydroxytryptamine receptor 2A Rattus norvegicus 97-103 8074188-2 1994 When A10 cells were incubated for 4 h in medium made hypertonic by addition of sucrose, there was a marked increase in Na(+)-dependent transport of alanine and proline but no change in Na(+)-dependent Pi uptake or Na(+)-independent uptake of leucine and inositol. Inositol 254-262 immunoglobulin kappa variable 6D-21 (non-functional) Homo sapiens 5-8 7982262-4 1994 Our conclusion that PTH activates the phosphoinositide cascade is based on data that demonstrate: (1) the Ca2+ transients evoked by the hormone are dependent on intracellular Ca2+ stores; (2) the hormone stimulates the release of radiolabeled inositol from GPC plasma membranes; and (3) the hormone stimulates a greater than 8-fold increase in cytosolic inositol-1,4,5-trisphosphate pool size. Inositol 243-251 parathyroid hormone Homo sapiens 20-23 8040341-4 1994 In accordance with this construct, N-nitro-L-arginine methyl ester, a competitive inhibitor of nitric oxide synthase reversed the increased nerve conduction velocity afforded by aldose reductase inhibitor treatment in the acutely diabetic rat without affecting the attendant correction of nerve sorbitol and myo-inositol. Inositol 308-320 aldo-keto reductase family 1 member B1 Rattus norvegicus 178-194 8031771-2 1994 This work addresses the question of whether phosphatidylinositol-specific phospholipase C (PI-PLC) could be involved in the generation of these chiro-inositol derivatives. Inositol 144-158 phosphatidylinositol-specific phospholipase C Bos taurus 44-89 8031771-2 1994 This work addresses the question of whether phosphatidylinositol-specific phospholipase C (PI-PLC) could be involved in the generation of these chiro-inositol derivatives. Inositol 144-158 phosphatidylinositol-specific phospholipase C Bos taurus 91-97 8031771-9 1994 These results suggest that the natural chiro-inositol derivatives should have the 1L-configuration if they are produced by PI-PLC, which is in contrast to the 1D-configuration reported by others. Inositol 39-53 phosphatidylinositol-specific phospholipase C Bos taurus 123-129 8037672-2 1994 Chemical and enzymic degradation studies have suggested that the PI-PLC resistance of AP is due to inositol acylation of its glycosylphosphatidylinositol (GPI) anchor. Inositol 99-107 phospholipase C beta 1 Homo sapiens 65-71 8037672-8 1994 The delayed appearance of PI-PLC resistance was unexpected as previous studies have suggested that candidate GPI-anchor precursors are PI-PLC-resistant as a result of inositol acylation. Inositol 167-175 phospholipase C beta 1 Homo sapiens 26-32 8037672-8 1994 The delayed appearance of PI-PLC resistance was unexpected as previous studies have suggested that candidate GPI-anchor precursors are PI-PLC-resistant as a result of inositol acylation. Inositol 167-175 phospholipase C beta 1 Homo sapiens 135-141 7948784-1 1994 myo-Inositol, a major compatible osmolyte in renal medulla, is accumulated in kidney-derived epithelial cells cultured in hypertonic media via Na/myoinositol cotransporter (SMIT). Inositol 0-12 solute carrier family 5 member 3 Rattus norvegicus 173-177 7948784-9 1994 These results indicate that there is osmoregulatory SMIT in the outer and inner medulla of the kidney and that myo-inositol accumulation in this region is probably due to the increased expression of the SMIT gene. Inositol 111-123 solute carrier family 5 member 3 Rattus norvegicus 203-207 7932382-0 1994 Functional platelet-activating factor receptors linked to inositol lipid hydrolysis, calcium mobilization and tyrosine kinase activity in the human endometrial HEC-1B cell line. Inositol 58-66 PCNA clamp associated factor Homo sapiens 11-37 8013664-9 1994 These data demonstrate that several, but not all, GFs acting through tyrosine kinase receptor induce the intranuclear translocation of PKC alpha and, because of the dramatic effect of IGF-I, strengthen the case for a link between the activation of nuclear inositol lipid cycle and PKC translocation induced by this GF. Inositol 256-264 protein kinase C, alpha Mus musculus 135-144 8013664-9 1994 These data demonstrate that several, but not all, GFs acting through tyrosine kinase receptor induce the intranuclear translocation of PKC alpha and, because of the dramatic effect of IGF-I, strengthen the case for a link between the activation of nuclear inositol lipid cycle and PKC translocation induced by this GF. Inositol 256-264 protein kinase C, alpha Mus musculus 135-138 8201009-1 1994 Sorbitol (aldose reductase) pathway flux in diabetes perturbs intracellular metabolism by two putative mechanisms: reciprocal osmoregulatory depletion of other organic osmolytes e.g., myo-inositol, and alterations in NADPH/NADP+ and/or NADH/NAD+. Inositol 184-196 aldo-keto reductase family 1 member B Homo sapiens 10-26 8201009-2 1994 The "osmolyte" and "redox" hypotheses predict secondary elevations in CDP-diglyceride, the rate-limiting precursor for phosphatidylinositol synthesis, but through different mechanisms: the "osmolyte" hypothesis via depletion of intracellular myo-inositol (the cosubstrate for phosphatidylinositol-synthase) and the "redox" hypothesis through enhanced de novo synthesis from triose phosphates. Inositol 242-254 cut like homeobox 1 Homo sapiens 70-73 8201009-4 1994 In high aldose reductase expressing retinal pigment epithelial cells, glucose-induced, aldose reductase inhibitor-sensitive CDP-diglyceride accumulation and inhibition of 32P-incorporation into phosphatidylinositol paralleled myo-inositol depletion (but not cytoplasmic redox, that was unaffected by glucose) and depletion of arachidonyl-diacylglycerol. Inositol 226-238 aldo-keto reductase family 1 member B Homo sapiens 8-24 8201009-6 1994 These results favor myo-inositol depletion rather than altered redox as the primary cause of glucose-induced aldose reductase-related defects in phospholipid metabolism in cultured retinal pigment epithelial cells. Inositol 20-32 aldo-keto reductase family 1 member B Homo sapiens 109-125 7514443-1 1994 We have analysed the levels of soluble inositol metabolites in HL60 cells as they differentiate towards neutrophils in response to a combination of all-trans-retinoic acid and granulocyte colony-stimulating factor and towards monocytes in response to 1 alpha-25-dihydroxyvitamin D3. Inositol 39-47 colony stimulating factor 3 Homo sapiens 176-213 7514386-5 1994 Purified U-CD59 released 1 mol of inositol per mole of protein by nitrous acid deamination, which cleaved between glucosamine and inositol present commonly in the GPI anchor. Inositol 34-42 CD59 molecule (CD59 blood group) Homo sapiens 11-15 7514386-5 1994 Purified U-CD59 released 1 mol of inositol per mole of protein by nitrous acid deamination, which cleaved between glucosamine and inositol present commonly in the GPI anchor. Inositol 130-138 CD59 molecule (CD59 blood group) Homo sapiens 11-15 7514386-6 1994 This indicates that a GPI anchor, which ended with inositol, is linked at the carboxy terminus of U-CD59. Inositol 51-59 CD59 molecule (CD59 blood group) Homo sapiens 100-104 7915914-4 1994 Human brain PtdIns synthase showed Kmapp values of 0.49 mM and 18 microM for inositol and CMP, respectively. Inositol 77-85 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 12-27 8056324-3 1994 Expression of the INO1, CHO1 and OPI3 genes was not fully derepressed in the absence of soluble lipid precursors, inositol and choline in the dep1 mutant, as compared to wild type. Inositol 114-122 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 18-22 8182533-5 1994 In addition, myoinositol, a precursor of the PKC-activating pathway, induced a 2-fold increase in PAH accumulation at a concentration of 10(-5) M. These effects were abolished by the administration of staurosporine at low concentrations (10(-9) and 10(-8) M). Inositol 13-24 phenylalanine-4-hydroxylase Oryctolagus cuniculus 98-101 8144596-2 1994 We have isolated a Saccharomyces cerevisiae GPI anchoring mutant, gpi1, using a colony screen for cells blocked in [3H]inositol incorporation into protein. Inositol 119-127 phosphatidylinositol N-acetylglucosaminyltransferase Saccharomyces cerevisiae S288C 66-70 8125733-3 1994 METHODS: The kinetic characteristics of myo-inositol accumulation based on the measurement of in vitro myo-[3H]inositol (3H-MI) uptake was determined with cultured BLECs incubated in either high ambient galactose or galactose-free, physiological medium under experimental conditions that included both aldose reductase inhibition and elevation of extracellular osmotonicity. Inositol 40-52 aldose reductase Bos taurus 302-318 8125734-3 1994 In hypertonic medium, the increase in myo-inositol accumulation is attributed to an elevation in activity of Na+/myo-inositol cotransporter(s). Inositol 38-50 sodium/myo-inositol cotransporter Bos taurus 109-139 8177372-8 1994 myo-Inositol metabolism and content and bradykinin-stimulated phosphatidylinositol synthesis were also maintained when media containing 30 mM glucose, galactose, or mannose was supplemented with 250 microM myo-inositol. Inositol 206-218 kininogen 1 Homo sapiens 40-50 8127678-4 1994 The expression of FAS3-lacZ reporter genes and the measurement of mRNA levels in regulatory mutants of phospholipid biosynthesis clearly indicated that FAS3 is regulated by inositol and choline. Inositol 173-181 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 152-156 8127678-5 1994 Previous studies have shown that the genes coding for fatty acid synthase, FAS1 and FAS2, are regulated by inositol (Chirala, S.S. [1992] Proc. Inositol 107-115 tetrafunctional fatty acid synthase subunit FAS1 Saccharomyces cerevisiae S288C 75-79 8127678-5 1994 Previous studies have shown that the genes coding for fatty acid synthase, FAS1 and FAS2, are regulated by inositol (Chirala, S.S. [1992] Proc. Inositol 107-115 trifunctional fatty acid synthase subunit FAS2 Saccharomyces cerevisiae S288C 84-88 8294482-1 1994 Uptake of inositol by Saccharomyces cerevisiae is regulated through transcriptional control of the gene that encodes the major inositol permease, ITR1 (Nikawa, J., Tsukagoshi, Y., and Yamashita, S. (1991) J. Biol. Inositol 10-18 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 146-150 8294482-4 1994 ITR1 mRNA abundance decreases when cells are transferred from medium without inositol to medium with inositol. Inositol 77-85 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 0-4 8294482-4 1994 ITR1 mRNA abundance decreases when cells are transferred from medium without inositol to medium with inositol. Inositol 101-109 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 0-4 8294482-6 1994 INO2 and INO4 are required for derepressed levels of ITR1 mRNA, and OPI1 is necessary for repression of transcript levels in response to inositol. Inositol 137-145 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 68-72 8294482-7 1994 The INO2, INO4, and OPI1 genes thus coordinate uptake of inositol to endogenous inositol biosynthesis and to phospholipid biosynthesis. Inositol 57-65 Ino2p Saccharomyces cerevisiae S288C 4-8 8294482-7 1994 The INO2, INO4, and OPI1 genes thus coordinate uptake of inositol to endogenous inositol biosynthesis and to phospholipid biosynthesis. Inositol 57-65 Ino4p Saccharomyces cerevisiae S288C 10-14 8294482-7 1994 The INO2, INO4, and OPI1 genes thus coordinate uptake of inositol to endogenous inositol biosynthesis and to phospholipid biosynthesis. Inositol 57-65 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 20-24 8294482-7 1994 The INO2, INO4, and OPI1 genes thus coordinate uptake of inositol to endogenous inositol biosynthesis and to phospholipid biosynthesis. Inositol 80-88 Ino2p Saccharomyces cerevisiae S288C 4-8 8294482-7 1994 The INO2, INO4, and OPI1 genes thus coordinate uptake of inositol to endogenous inositol biosynthesis and to phospholipid biosynthesis. Inositol 80-88 Ino4p Saccharomyces cerevisiae S288C 10-14 8294482-7 1994 The INO2, INO4, and OPI1 genes thus coordinate uptake of inositol to endogenous inositol biosynthesis and to phospholipid biosynthesis. Inositol 80-88 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 20-24 8294482-8 1994 Repression of transcription of ITR1 also requires ongoing synthesis of phosphatidylcholine, defining an additional link between synthesis of phospholipids and regulation of inositol uptake. Inositol 173-181 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 31-35 8294482-9 1994 Analysis showed that the INO1 gene, encoding a key enzyme in the inositol biosynthetic pathway, responded to decreases in permease activity with a graduated increase in the level of INO1 mRNA. Inositol 65-73 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 25-29 8294482-9 1994 Analysis showed that the INO1 gene, encoding a key enzyme in the inositol biosynthetic pathway, responded to decreases in permease activity with a graduated increase in the level of INO1 mRNA. Inositol 65-73 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 182-186 8294482-11 1994 Inactivation of the ITR1 permease occurs in response to the presence of inositol and involves a change in the functional half-life of the protein. Inositol 72-80 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 20-24 8188619-6 1994 An scs1/ino2 null mutant constructed by gene replacement was viable, but auxotrophic for inositol and choline, and used for determination of the mRNA levels of various phospholipid-synthesizing enzymes. Inositol 89-97 Ino2p Saccharomyces cerevisiae S288C 8-12 8188619-7 1994 In agreement with the reported data for ino2 mutants the disruptant showed decreased expression of the INO1 and PSS genes, which are known to be regulated by inositol and choline. Inositol 158-166 Ino2p Saccharomyces cerevisiae S288C 40-44 8188619-7 1994 In agreement with the reported data for ino2 mutants the disruptant showed decreased expression of the INO1 and PSS genes, which are known to be regulated by inositol and choline. Inositol 158-166 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 103-107 8188619-8 1994 In addition, we newly found that the disruption of SCS1/INO2 also caused a decrease in the expression of the CKI, PEM1, and PEM2 genes, which we previously showed to belong to the inositol-choline-regulated gene family. Inositol 180-188 Ino2p Saccharomyces cerevisiae S288C 56-60 8188619-8 1994 In addition, we newly found that the disruption of SCS1/INO2 also caused a decrease in the expression of the CKI, PEM1, and PEM2 genes, which we previously showed to belong to the inositol-choline-regulated gene family. Inositol 180-188 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 114-118 8188619-8 1994 In addition, we newly found that the disruption of SCS1/INO2 also caused a decrease in the expression of the CKI, PEM1, and PEM2 genes, which we previously showed to belong to the inositol-choline-regulated gene family. Inositol 180-188 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 124-128 8188619-9 1994 These results confirm and strengthen the conclusion that the SCS1/INO2 gene is required for expression of inositol-choline-regulated genes in phospholipid synthesis. Inositol 106-114 Ino2p Saccharomyces cerevisiae S288C 66-70 8263514-0 1994 Decreased myo-inositol uptake is associated with reduced bradykinin-stimulated phosphatidylinositol synthesis and diacylglycerol content in cultured neuroblastoma cells exposed to L-fucose. Inositol 10-22 kininogen 1 Homo sapiens 57-67 8263514-3 1994 In these studies, L-fucose supplementation of culture medium was used to assess the effect of decreased myo-inositol metabolism and content on bradykinin-stimulated phosphatidylinositol synthesis and diacylglycerol production. Inositol 104-116 kininogen 1 Homo sapiens 143-153 8131066-0 1993 Myo-inositol reduces serotonin (5-HT2) receptor induced homologous and heterologous desensitization. Inositol 0-12 5-hydroxytryptamine receptor 2A Rattus norvegicus 21-47 8253518-2 1993 Previous studies indicated that AMF stimulates motility by binding to its receptor, a cell-surface glycoprotein of 78 kDa (gp78), inducing its phosphorylation, activating a pertussis toxin (PT)-sensitive G-protein, and stimulating inositol metabolism. Inositol 231-239 glucose-6-phosphate isomerase 1 Mus musculus 32-35 8243820-5 1993 If polyol accumulation was prevented with sorbinil, an aldose reductase inhibitor, the inhibition of myo-inositol influx was partially reduced. Inositol 101-113 aldo-keto reductase family 1 member B1 Rattus norvegicus 55-71 7934871-3 1993 The results show that the expression of the two ITR genes is differently regulated: ITR1 was repressed by inositol and choline whereas ITR2 was constitutive. Inositol 106-114 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 84-88 7934871-3 1993 The results show that the expression of the two ITR genes is differently regulated: ITR1 was repressed by inositol and choline whereas ITR2 was constitutive. Inositol 106-114 myo-inositol transporter ITR2 Saccharomyces cerevisiae S288C 135-139 7934871-4 1993 Deletion analysis of the ITR1 upstream region and comparison with the upstream regions of other genes involved in phospholipid synthesis indicate that the octamer sequence 5"-TTCACATG-3" is important for the expression and inositol/choline regulation of the ITR1 gene. Inositol 223-231 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 25-29 7934871-4 1993 Deletion analysis of the ITR1 upstream region and comparison with the upstream regions of other genes involved in phospholipid synthesis indicate that the octamer sequence 5"-TTCACATG-3" is important for the expression and inositol/choline regulation of the ITR1 gene. Inositol 223-231 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 258-262 8264542-5 1993 Expression of the CTR/HNM1 gene in wild-type cells is regulated by the phospholipid precursors inositol and choline; no such influence is seen in cells bearing mutations in the phospholipid regulatory genes INO2, INO4, and OPI1. Inositol 95-103 Hnm1p Saccharomyces cerevisiae S288C 22-26 8241249-1 1993 The cloned Na+/D-glucose cotransporter SGLT1 and an additional recently isolated human kidney cDNA Hu14/K15 belong to a family of similar cotransport proteins including the Na(+)-dependent nucleoside and Na(+)-dependent myo-inositol carrier SMIT1. Inositol 220-232 solute carrier family 5 member 1 Homo sapiens 39-44 8241249-1 1993 The cloned Na+/D-glucose cotransporter SGLT1 and an additional recently isolated human kidney cDNA Hu14/K15 belong to a family of similar cotransport proteins including the Na(+)-dependent nucleoside and Na(+)-dependent myo-inositol carrier SMIT1. Inositol 220-232 keratin 15 Homo sapiens 104-107 8246231-0 1993 Synthesis and evaluation of 3-modified 1D-myo-inositols as inhibitors and substrates of phosphatidylinositol synthase and inhibitors of myo-inositol uptake by cells. Inositol 42-54 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) Mus musculus 88-117 8293297-0 1993 Inositol treatment raises CSF inositol levels. Inositol 0-8 colony stimulating factor 2 Homo sapiens 26-29 8293297-0 1993 Inositol treatment raises CSF inositol levels. Inositol 30-38 colony stimulating factor 2 Homo sapiens 26-29 8293297-3 1993 Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy. Inositol 5-13 colony stimulating factor 2 Homo sapiens 73-76 8293297-3 1993 Oral inositol treatment of 8 patients is shown to significantly increase CSF inositol by almost 70%, suggesting possible CNS therapeutic applications of this compound and possible CNS side-effects of systemic therapy. Inositol 77-85 colony stimulating factor 2 Homo sapiens 73-76 8234346-1 1993 D-chiro-inositol is a rare inositol isomer present in inositol phosphoglycans which are proposed mediators of insulin action. Inositol 0-16 insulin Homo sapiens 110-117 8234346-1 1993 D-chiro-inositol is a rare inositol isomer present in inositol phosphoglycans which are proposed mediators of insulin action. Inositol 8-16 insulin Homo sapiens 110-117 8234346-5 1993 The renal clearance of D-chiro-inositol was selectively elevated in both non-insulin-dependent and insulin-dependent diabetes when compared with the clearances of L-chiro-inositol or myo-inositol and exceeded the glomerular filtration rate in 71% of the diabetics but in none of the nondiabetics. Inositol 23-39 insulin Homo sapiens 77-84 8234346-6 1993 In poorly controlled diabetic patients insulin treatment reduced urinary D-chiro-inositol losses by 63% and increased plasma levels by 8.8-fold. Inositol 73-89 insulin Homo sapiens 39-46 8415767-0 1993 Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in culture. Inositol 49-57 aldo-keto reductase family 1 member B Homo sapiens 20-36 8404893-3 1993 In parallel experiments performed with [3H]myo-inositol-labelled granulosa cells, treatment with PRL stimulated (Ose)nPtdIns hydrolysis in a similar manner, whereas no effect on phosphoinositide (PtdIns, PtdInsP and PtdInsP2) turnover could be observed. Inositol 43-55 prolactin Rattus norvegicus 97-100 8214052-5 1993 High basal expression of the aldose reductase gene was associated with rapid sorbitol accumulation and myo-inositol depletion in response to hyperglycemic (20 mM) concentrations of glucose. Inositol 103-115 aldo-keto reductase family 1 member B Homo sapiens 29-45 8214052-7 1993 Thus the pattern of response of myo-inositol to hyperglycemic and hyperosmotic levels of glucose and mannitol was related to the degree of basal aldose reductase gene expression, which may therefore influence the development of diabetic complications. Inositol 32-44 aldo-keto reductase family 1 member B Homo sapiens 145-161 7691427-6 1993 The expression of cytokeratin and CEA were both augmented by either InsP6 or inositol at all concentrations tested, although the degree of augmentation was milder with inositol than with InsP6. Inositol 77-85 CEA cell adhesion molecule 3 Homo sapiens 34-37 7691427-6 1993 The expression of cytokeratin and CEA were both augmented by either InsP6 or inositol at all concentrations tested, although the degree of augmentation was milder with inositol than with InsP6. Inositol 168-176 CEA cell adhesion molecule 3 Homo sapiens 34-37 8349037-11 1993 Inositol phosphoglycan mimicked the action of insulin on both forms of the enzyme from adult hepatocytes, whereas in fetal cells insulin did not change, and purified inositol phosphoglycan reduced the activities of glycogen phosphorylase. Inositol 0-8 glycogen phosphorylase L Rattus norvegicus 215-237 8349037-11 1993 Inositol phosphoglycan mimicked the action of insulin on both forms of the enzyme from adult hepatocytes, whereas in fetal cells insulin did not change, and purified inositol phosphoglycan reduced the activities of glycogen phosphorylase. Inositol 166-174 glycogen phosphorylase L Rattus norvegicus 215-237 7689147-1 1993 Fibroblasts transformed by v-src or by related oncogenes encoding activated tyrosine kinases contain elevated levels of polyphosphoinositides with phosphate at the D-3 position of the inositol ring, as a result of the activation of phosphatidylinositol (PI) 3"-kinase. Inositol 184-192 SRC proto-oncogene, non-receptor tyrosine kinase Gallus gallus 29-32 8356081-0 1993 Insulin stimulates the biosynthesis of chiro-inositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor. Inositol 39-53 insulin Homo sapiens 0-7 8356081-0 1993 Insulin stimulates the biosynthesis of chiro-inositol-containing phospholipids in a rat fibroblast line expressing the human insulin receptor. Inositol 39-53 insulin receptor Homo sapiens 125-141 8356081-4 1993 Further detailed analysis of individual [3H]inositol-containing phospholipids demonstrated marked increases in specific activity of the chiro-[3H]inositol phospholipids after 15 min of incubation with insulin: phosphatidylinositol 4-phosphate and 4,5-bisphosphate, 4.2-fold; lysophosphatidylinositol, 1.5-fold; phosphatidylinositol, 3.2-fold. Inositol 44-52 insulin Homo sapiens 201-208 8356081-6 1993 These findings indicate that insulin stimulates de novo synthesis of chiro-inositol-containing phospholipids at the inositol phospholipid level. Inositol 69-83 insulin Homo sapiens 29-36 8325441-4 1993 Aldose reductase inhibitors are thought to lower tissue sorbitol while increasing myo-inositol. Inositol 82-94 aldo-keto reductase family 1 member B1 Rattus norvegicus 0-16 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 21-29 thyrotropin releasing hormone Rattus norvegicus 81-110 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 21-29 thyrotropin releasing hormone Rattus norvegicus 112-115 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 169-177 thyrotropin releasing hormone Rattus norvegicus 81-110 8392378-1 1993 Previous work in [3H]inositol-labelled GH3 pituitary tumor cells stimulated with thyrotropin-releasing hormone (TRH) reported the existence of at least ten distinct [3H]inositol-containing substances which were identified as different inositol mono-, bis- and tris-phosphate isomers [1]. Inositol 169-177 thyrotropin releasing hormone Rattus norvegicus 112-115 8325896-4 1993 Inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate-limiting enzyme in isoprenoid and sterol biosynthesis, by the cholesterol-lowering drug, lovastatin, blocks Fc epsilon RI-dependent [3H] serotonin ([3H]5HT) release from the mast cell line, RBL-2H3. Inositol 276-279 3-hydroxy-3-methylglutaryl-CoA reductase Rattus norvegicus 14-71 8314848-0 1993 SAC1p is an integral membrane protein that influences the cellular requirement for phospholipid transfer protein function and inositol in yeast. Inositol 126-134 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 0-5 8314848-5 1993 Finally, we report that sac1 mutants also exhibit a specific inositol auxotrophy that is not exhibited by the other sac mutant strains. Inositol 61-69 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 24-28 8314848-6 1993 This sac1-associated inositol auxotrophy is not manifested by measurable defects in de novo inositol biosynthesis, nor is it the result of some obvious defect in the ability of sac1 mutants to utilize inositol for phosphatidylinositol biosynthesis. Inositol 21-29 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 5-9 8314848-7 1993 Thus, sac1 mutants represent a novel class of inositol auxotroph in that these mutants appear to require elevated levels of inositol for growth. Inositol 46-54 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 6-10 8314848-7 1993 Thus, sac1 mutants represent a novel class of inositol auxotroph in that these mutants appear to require elevated levels of inositol for growth. Inositol 124-132 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 6-10 8314848-8 1993 On the basis of the collective data, we suggest that SAC1p dysfunction exerts its pleiotropic effects on yeast Golgi function, the organization of the actin cytoskeleton, and the cellular requirement for inositol, through altered metabolism of inositol glycerophospholipids. Inositol 204-212 phosphatidylinositol-3-phosphatase SAC1 Saccharomyces cerevisiae S288C 53-58 8392181-1 1993 chiro- and myo-Inositols are major components of the two inositol phosphoglycan mediators of insulin action. Inositol 15-24 insulin Homo sapiens 93-100 8392181-1 1993 chiro- and myo-Inositols are major components of the two inositol phosphoglycan mediators of insulin action. Inositol 57-65 insulin Homo sapiens 93-100 7686045-6 1993 Additional experiments demonstrate that increasing charge density enhances the ability of polyanions such as sulfated beta-cyclodextrins, phosphorylated inositols, and modified heparins to protect aFGF from urea-induced unfolding. Inositol 153-162 fibroblast growth factor 1 Homo sapiens 197-201 8513503-6 1993 IRE1 is also required for inositol prototrophy, suggesting that the induction of ER resident proteins is coupled to the biogenesis of new ER membrane. Inositol 26-34 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 0-4 8098706-7 1993 ACC1 transcription was repressed 3-fold by lipid precursors, inositol and choline, and was also controlled by regulatory factors Ino2p, Ino4p, and Opi1p, providing evidence that the key step of fatty acid synthesis is regulated in conjunction with phospholipid synthesis at the level of gene expression. Inositol 61-69 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 0-4 8098706-8 1993 The 5"-untranslated region of the ACC1 gene contains a sequence reminiscent of an inositol/choline-responsive element identified in genes encoding phospholipid biosynthetic enzymes. Inositol 82-90 acetyl-CoA carboxylase ACC1 Saccharomyces cerevisiae S288C 34-38 8486709-1 1993 The Saccharomyces cerevisiae Gas1 protein is synthesized as a precursor with a hydrophobic extension at the carboxyl terminus which is removed and replaced with an inositol containing glycolipid that anchors the protein to the plasma membrane. Inositol 164-172 1,3-beta-glucanosyltransferase GAS1 Saccharomyces cerevisiae S288C 29-33 8389541-2 1993 Stimulation of [3H]-inositol labeled pancreatic minilobules by buffer, bombesin, neuromedin B or carbachol in presence of 10 mM lithium, followed by separation of inositol phosphates, yielded the following results for cyclic inositol monophosphate (cIP) [DPM/mg protein; Mean +/- SEM (n)]: control [21 +/- 6, (9)]; bombesin [145 +/- 24, (12)]; neuromedin B (99 +/- 22 (9)] and carbachol [512 +/- 60, (12)]. Inositol 20-28 neuromedin B Rattus norvegicus 81-93 8389541-2 1993 Stimulation of [3H]-inositol labeled pancreatic minilobules by buffer, bombesin, neuromedin B or carbachol in presence of 10 mM lithium, followed by separation of inositol phosphates, yielded the following results for cyclic inositol monophosphate (cIP) [DPM/mg protein; Mean +/- SEM (n)]: control [21 +/- 6, (9)]; bombesin [145 +/- 24, (12)]; neuromedin B (99 +/- 22 (9)] and carbachol [512 +/- 60, (12)]. Inositol 20-28 neuromedin B Rattus norvegicus 344-356 8482720-3 1993 The glucosamine C-1 appears to be linked through a glycosidic bond to the myoinositol molecule of the IPG moiety as revealed by the generation of phosphatidylinositol (PtdIns) after nitrous acid deamination of dual labelled ([3H]glucosamine/[14C]palmitate or [3H]glucosamine/[14C]myristate) glycosyl-phosphatidylinositol. Inositol 74-85 heterogeneous nuclear ribonucleoprotein C Homo sapiens 16-19 8387272-2 1993 Only three of the monodeoxyfluoro-myo-inositols were incorporated into the phospholipids of thymocytes: 1D-3-deoxy-3-fluoro-myo-inositol, 5-deoxy-5-fluoro-myo-inositol and 1D-6-deoxy-6-fluoro-myo-inositol, all of which were weaker substrates for phosphatidylinositol synthase than was myo-inositol. Inositol 34-46 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 246-275 8462454-0 1993 The involvement of inositol phosphoglycan mediators in the modulation of steroidogenesis by insulin and insulin-like growth factor-I. Inositol 19-27 insulin Sus scrofa 92-99 8462454-0 1993 The involvement of inositol phosphoglycan mediators in the modulation of steroidogenesis by insulin and insulin-like growth factor-I. Inositol 19-27 insulin like growth factor 1 Sus scrofa 104-132 8462454-8 1993 Based on these observations, we propose that the release of inositol phosphoglycans into the extracellular medium plays an important role in the signaling mechanisms by which insulin and IGF-I regulate the synthesis of progesterone in swine ovary granulosa cells. Inositol 60-68 insulin Sus scrofa 175-182 8462454-8 1993 Based on these observations, we propose that the release of inositol phosphoglycans into the extracellular medium plays an important role in the signaling mechanisms by which insulin and IGF-I regulate the synthesis of progesterone in swine ovary granulosa cells. Inositol 60-68 insulin like growth factor 1 Sus scrofa 187-192 8455027-0 1993 Lithium enhances muscarinic receptor-stimulated CDP-diacylglycerol formation in inositol-depleted SK-N-SH neuroblastoma cells. Inositol 80-88 cut like homeobox 1 Homo sapiens 48-51 8455027-3 1993 In the present study, the effect of Li+ on muscarinic receptor-stimulated formation of the immediate precursor of phosphatidylinositol, CDP-diacylglycerol (CDP-DAG), has been examined in human SK-N-SH neuroblastoma cells that have been cultured under conditions that alter the cellular content of myo-inositol. Inositol 297-309 cut like homeobox 1 Homo sapiens 136-139 8455027-7 1993 This result was in sharp contrast to findings in rat brain slices, in which carbachol-stimulated formation of [3H]CDP-DAG was potentiated approximately 10-fold by Li+ and substantially reduced by coincubation with inositol. Inositol 214-222 cut like homeobox 1 Homo sapiens 114-117 7683151-4 1993 Digestion analyses with phosphatidylinositol-specific phospholipase C, an enzyme that releases GPI-anchored proteins from cell surfaces, showed that DAF and CD59 molecules with GPI anchors containing unacylated inositol were preferentially lost. Inositol 36-44 CD55 molecule (Cromer blood group) Homo sapiens 149-152 7683151-4 1993 Digestion analyses with phosphatidylinositol-specific phospholipase C, an enzyme that releases GPI-anchored proteins from cell surfaces, showed that DAF and CD59 molecules with GPI anchors containing unacylated inositol were preferentially lost. Inositol 36-44 CD59 molecule (CD59 blood group) Homo sapiens 157-161 8384449-14 1993 The vasopressin-induced increase in inositol phosphates plus myo-inositol (approx. Inositol 61-73 arginine vasopressin Rattus norvegicus 4-15 8436962-7 1993 PLA2 activity is much higher in GCPs than that of phospholipase C, as demonstrated by the comparison of AA and inositol turnover, by the low levels of 1,2-diacylglycerol generated by GCPs, and by the resistance of AA release to treatment of GCPs with RHC-80267, a specific inhibitor of diacylglycerol lipase. Inositol 111-119 phospholipase A2 group IB Rattus norvegicus 0-4 8428006-6 1993 On the other hand, lysophosphatidylinositol formation, which is a direct indicator of phospholipase A2 (PLA2) activation, was found to be normal when the [3H]-inositol-labeled platelets were challenged with STA2. Inositol 35-43 phospholipase A2 group IB Homo sapiens 86-102 8428006-6 1993 On the other hand, lysophosphatidylinositol formation, which is a direct indicator of phospholipase A2 (PLA2) activation, was found to be normal when the [3H]-inositol-labeled platelets were challenged with STA2. Inositol 35-43 phospholipase A2 group IB Homo sapiens 104-108 8425483-1 1993 I. Urinary excretion rate of chiroinositol is directly associated with insulin resistance in spontaneously diabetic rhesus monkeys. Inositol 29-42 insulin Macaca mulatta 71-78 8425483-4 1993 As in humans, monkeys with NIDDM have a lower urinary excretion rate of chiroinositol (CI), a component of a putative mediator of insulin action, compared to normal monkeys. Inositol 72-85 insulin Homo sapiens 130-137 8425483-4 1993 As in humans, monkeys with NIDDM have a lower urinary excretion rate of chiroinositol (CI), a component of a putative mediator of insulin action, compared to normal monkeys. Inositol 87-89 insulin Homo sapiens 130-137 8425485-2 1993 Acute glycogenic and hypoglycemic effects of two inositol phosphoglycan insulin mediators in normal and streptozotocin-diabetic rats in vivo. Inositol 49-57 insulin Bos taurus 72-79 8180414-7 1993 Chemical derivatization experiments of cyclic PIP suggest the phosphate to be bound to myo-inositol and the myo-inositol phosphate to the prostaglandin E by its C15-hydroxyl group. Inositol 87-99 prolactin induced protein Rattus norvegicus 46-49 7678726-9 1993 Increasing phosphorylation of inositol compounds (up to six phosphate groups per molecule) enhances the thermal stability of aFGF. Inositol 30-38 fibroblast growth factor 1 Homo sapiens 125-129 8012448-2 1993 Mutant strains in which the INO2 chromosomal locus has been deleted show pleiotropic phenotypes under growth conditions of inositol/choline availability. Inositol 123-131 Ino2p Saccharomyces cerevisiae S288C 28-32 7870890-6 1993 The levels of cortical myo-inositol in rats injected with myo-inositol were approximately double those of the CSF and L-chiro-inositol groups. Inositol 58-70 colony stimulating factor 2 Rattus norvegicus 110-113 1464502-2 1992 Restoration of myo-inositol uptake by aldose reductase inhibition. Inositol 15-27 aldose reductase Bos taurus 38-54 1461729-3 1992 We have investigated the influence of a functional INO4 gene previously described as a regulator of inositol biosynthesis on the expression of FAS1 and FAS2. Inositol 100-108 Ino4p Saccharomyces cerevisiae S288C 51-55 1329966-4 1992 This observation suggests that, as previously reported for human erythrocyte AChE, an acylation of the inositol ring in the glycolipid anchor of rabbit erythrocyte AChE (that does not occur in lymphocytes) prevents the cleavage. Inositol 103-111 acetylcholinesterase (Cartwright blood group) Homo sapiens 77-81 1329966-4 1992 This observation suggests that, as previously reported for human erythrocyte AChE, an acylation of the inositol ring in the glycolipid anchor of rabbit erythrocyte AChE (that does not occur in lymphocytes) prevents the cleavage. Inositol 103-111 ACE-1 Oryctolagus cuniculus 164-168 1331066-5 1992 In each case, the stimulation of PLD correlated closely with the ability to stimulate inositol phospholipid breakdown and was entirely dependent on the activation of protein kinase C. Moreover, the ability of both thrombin and carbachol to stimulate PLD was found to be rapidly desensitized, with a similar time course of desensitization (t1/2 desensitization, 90 s). Inositol 86-94 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 33-36 1331066-5 1992 In each case, the stimulation of PLD correlated closely with the ability to stimulate inositol phospholipid breakdown and was entirely dependent on the activation of protein kinase C. Moreover, the ability of both thrombin and carbachol to stimulate PLD was found to be rapidly desensitized, with a similar time course of desensitization (t1/2 desensitization, 90 s). Inositol 86-94 coagulation factor II, thrombin Homo sapiens 214-222 1425685-8 1992 Since fly rhodopsin is coupled to phospholipase C, studies of the interaction of rhodopsin with rhodopsin kinase can be useful in analysis of the reactions that lead to termination of the inositol-phospholipid-signaling pathway. Inositol 188-196 neither inactivation nor afterpotential E Drosophila melanogaster 10-19 1425685-8 1992 Since fly rhodopsin is coupled to phospholipase C, studies of the interaction of rhodopsin with rhodopsin kinase can be useful in analysis of the reactions that lead to termination of the inositol-phospholipid-signaling pathway. Inositol 188-196 Phospholipase C at 21C Drosophila melanogaster 34-49 1425685-8 1992 Since fly rhodopsin is coupled to phospholipase C, studies of the interaction of rhodopsin with rhodopsin kinase can be useful in analysis of the reactions that lead to termination of the inositol-phospholipid-signaling pathway. Inositol 188-196 neither inactivation nor afterpotential E Drosophila melanogaster 81-90 1425685-8 1992 Since fly rhodopsin is coupled to phospholipase C, studies of the interaction of rhodopsin with rhodopsin kinase can be useful in analysis of the reactions that lead to termination of the inositol-phospholipid-signaling pathway. Inositol 188-196 G protein-coupled receptor kinase 1 Drosophila melanogaster 96-112 1435749-1 1992 Epidermal growth factor (EGF) can stimulate inositol lipid hydrolysis in rat hepatocytes and can accelerate GTP/GDP exchange in hepatic membranes. Inositol 44-52 epidermal growth factor like 1 Rattus norvegicus 0-23 1435749-1 1992 Epidermal growth factor (EGF) can stimulate inositol lipid hydrolysis in rat hepatocytes and can accelerate GTP/GDP exchange in hepatic membranes. Inositol 44-52 epidermal growth factor like 1 Rattus norvegicus 25-28 1337014-7 1992 It is concluded that streptozotocin diabetes causes a significant reduction of adrenergic contractile responses of the anococcygeus to electrical field stimulation by a prejunctional mechanism, and the reduction can be prevented by treating the animals with the aldose reductase inhibitor sorbinil or with myo-inositol. Inositol 306-318 aldo-keto reductase family 1 member B1 Rattus norvegicus 262-278 1403781-1 1992 A possible relationship between aldose reductase activity and myo-inositol levels and endothelium-dependent relaxations was examined in isolated rabbit aorta incubated with elevated concentrations of glucose (44 mM) for 6 hr to mimic hyperglycemic conditions. Inositol 62-74 aldo-keto reductase family 1 member B1 Oryctolagus cuniculus 32-48 1384043-2 1992 One apparent substrate for these enzymes is phosphatidylinositol 3-kinase (PI 3-kinase), an enzyme that phosphorylates the D-3 position of the inositol ring and associates with several protein tyrosine kinases, as indicated by the fact that it is immunoprecipitated from EGF-, bFGF-, and NGF-stimulated PC12 cells by an anti-phosphotyrosine antibody. Inositol 56-64 fibroblast growth factor 2 Rattus norvegicus 277-281 1384043-2 1992 One apparent substrate for these enzymes is phosphatidylinositol 3-kinase (PI 3-kinase), an enzyme that phosphorylates the D-3 position of the inositol ring and associates with several protein tyrosine kinases, as indicated by the fact that it is immunoprecipitated from EGF-, bFGF-, and NGF-stimulated PC12 cells by an anti-phosphotyrosine antibody. Inositol 56-64 nerve growth factor Rattus norvegicus 288-291 1530586-0 1992 Granulocyte/macrophage colony-stimulating factor affects myo-inositol metabolism in a novel manner. Inositol 57-69 colony stimulating factor 2 Homo sapiens 0-48 1530586-3 1992 This study has used myo-[3H]inositol-labelled human neutrophils to determine whether preincubation with GM-CSF influences myo-inositol (Ins) metabolism in control cells, or in cells stimulated with the bacterial chemoattractant N-formyl-methionyl-leucyl-phenylalanine (fMetLeuPhe). Inositol 122-134 colony stimulating factor 2 Homo sapiens 104-110 1530586-3 1992 This study has used myo-[3H]inositol-labelled human neutrophils to determine whether preincubation with GM-CSF influences myo-inositol (Ins) metabolism in control cells, or in cells stimulated with the bacterial chemoattractant N-formyl-methionyl-leucyl-phenylalanine (fMetLeuPhe). Inositol 136-139 colony stimulating factor 2 Homo sapiens 104-110 1360444-6 1992 The result ruled out the possibility that the PI-PLC-resistant Thy-1 had a transmembranous peptide sequence, and suggested the presence of an additional fatty acyl group on the inositol ring of the Thy-1 anchor. Inositol 177-185 protein disulfide isomerase associated 3 Mus musculus 46-52 1360444-6 1992 The result ruled out the possibility that the PI-PLC-resistant Thy-1 had a transmembranous peptide sequence, and suggested the presence of an additional fatty acyl group on the inositol ring of the Thy-1 anchor. Inositol 177-185 thymus cell antigen 1, theta Mus musculus 63-68 1360444-6 1992 The result ruled out the possibility that the PI-PLC-resistant Thy-1 had a transmembranous peptide sequence, and suggested the presence of an additional fatty acyl group on the inositol ring of the Thy-1 anchor. Inositol 177-185 thymus cell antigen 1, theta Mus musculus 198-203 1324861-1 1992 The (Na+,K+)-ATPase activity operative in rabbit aortic intima-media incubated with normal plasma levels of glucose and myo-inositol (70 mumol/l) is decreased when the glucose content of the medium is raised from 5 to 10 mmol/l or higher; this effect is prevented by aldose reductase inhibitors and by raising the myo-inositol content of the medium to 500 mumol/l. Inositol 120-132 aldo-keto reductase family 1 member B1 Oryctolagus cuniculus 267-283 1325151-6 1992 When [3H]inositol-loaded glomerulosa cells were stimulated with alpha-MSH there was significant generation of [3H]inositol trisphosphate (IP3) at concentrations of alpha-MSH which stimulated secretion of aldosterone. Inositol 9-17 proopiomelanocortin Rattus norvegicus 64-73 1325151-6 1992 When [3H]inositol-loaded glomerulosa cells were stimulated with alpha-MSH there was significant generation of [3H]inositol trisphosphate (IP3) at concentrations of alpha-MSH which stimulated secretion of aldosterone. Inositol 9-17 proopiomelanocortin Rattus norvegicus 164-173 1392081-3 1992 We have recently shown that pituitary adenylate cyclase activating peptide (PACAP) has neurotrophic properties and activates both adenylylcyclase and the inositol lipid cascade in PC12 cells. Inositol 154-162 adenylate cyclase activating polypeptide 1 Rattus norvegicus 28-74 1392081-3 1992 We have recently shown that pituitary adenylate cyclase activating peptide (PACAP) has neurotrophic properties and activates both adenylylcyclase and the inositol lipid cascade in PC12 cells. Inositol 154-162 adenylate cyclase activating polypeptide 1 Rattus norvegicus 76-81 1637307-1 1992 Addition of epidermal growth factor (EGF) to quiescent Swiss 3T3 cells resulted in a sustained increase in cellular diacylglycerol (DG) content in the absence of inositol-lipid hydrolysis. Inositol 162-170 epidermal growth factor Mus musculus 12-35 1625574-0 1992 IRE1 encodes a putative protein kinase containing a membrane-spanning domain and is required for inositol phototrophy in Saccharomyces cerevisiae. Inositol 97-105 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 0-4 1625574-1 1992 A novel gene, IRE1, of Saccharomyces cerevisiae was cloned through genetic complementation of a myoinositol auxotrophic mutant. Inositol 96-107 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 14-18 1625574-4 1992 Disruption of the IRE1 locus caused myo-inositol auxotrophy. Inositol 36-48 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 18-22 1625574-5 1992 The IRE1 product is very likely a protein kinase required for myo-inositol synthesis. Inositol 62-74 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 4-8 1317169-0 1992 Inositol phospholipid-induced suppression of F-actin-gelating activity of smooth muscle filamin. Inositol 0-8 filamin C Homo sapiens 88-95 1368234-1 1992 Phosphatidylinositol-glycan-specific phospholipase D (PI-G PLD) specifically hydrolyzes the inositol-phosphate linkage in phosphatidylinositol-glycan (PI-G) anchored proteins. Inositol 12-20 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 54-62 1510877-1 1992 When Rat-1 cells bearing the ts LA29 mutant of Rous sarcoma virus (Rat1 LA29) are shifted from restrictive to permissive temperature, the pp60v-Src tyrosine kinase is activated and there is an increase in the cellular level of sn1,2-diacylglycerol (DRG) within 30 min which is not accompanied by increased inositol phospholipid hydrolysis. Inositol 306-314 SRC proto-oncogene, non-receptor tyrosine kinase Rattus norvegicus 144-147 1563780-9 1992 We conclude that at least two different parts of the molecule are involved in the induction of TNF secretion by parasite exoantigens: one requires the presence of a phosphate bound to inositol, and, since dephosphorylated exoantigens were also inhibitory, one does not. Inositol 184-192 tumor necrosis factor Mus musculus 95-98 1628898-9 1992 These findings confirm our conclusion that exoantigens from these different species contain phosphate bound to inositol in their TNF-inducing moiety. Inositol 111-119 tumor necrosis factor Homo sapiens 129-132 1314495-4 1992 This was done to assess the degree of inhibition of PI synthase under various degrees of D-myo-inositol depletion and sorbitol accumulation induced by glucose and other metabolic manipulations in cultured human retinal pigment epithelial cells, a new in vitro model for diabetic complications. Inositol 89-103 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 52-63 1314495-5 1992 The results suggest that sorbitol accumulation limits the PI synthase reaction in these cells by selectively depleting specific intracellular pools of D-myo-inositol and/or by possible independent effects of sorbitol on PI synthase. Inositol 151-165 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 58-69 1545129-2 1992 In our study, we have examined the possible effects of the stable ATP analog adenosine 5"-O-[3-thiotriphosphate] (ATP gamma S) on cellular levels of inositol 1,4,5-trisphosphate, [Ca2+]i and diglyceride (DG), in resting and in FMLP-stimulated neutrophils. Inositol 149-157 formyl peptide receptor 1 Homo sapiens 227-231 1588909-6 1992 Two of the ts mutants (rpo21-4 and rpo21-7) display pleiotropic phenotypes, including an auxotrophy for inositol and a decreased proliferation rate at the permissive temperature. Inositol 104-112 DNA-directed RNA polymerase II core subunit RPO21 Saccharomyces cerevisiae S288C 23-28 1588909-6 1992 Two of the ts mutants (rpo21-4 and rpo21-7) display pleiotropic phenotypes, including an auxotrophy for inositol and a decreased proliferation rate at the permissive temperature. Inositol 104-112 DNA-directed RNA polymerase II core subunit RPO21 Saccharomyces cerevisiae S288C 35-40 1313970-1 1992 A 34 base-pair (bp) fragment spanning sequences -154 to -120 of the promoter of the CHO1 gene (structural gene for phosphatidylserine synthase) from the yeast Saccharomyces cerevisiae has been shown to place transcription of a promoter-less Escherichia coli lacZ gene under control of the phospholipid precursors inositol and choline. Inositol 313-321 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 84-88 1312085-2 1992 Both the 27- and 38-amino acid forms of PACAP elevate cAMP levels in PC12 cells and stimulate adenylylcyclase in PC12 membranes, with an EC50 near 10(-9) M. PACAP38 additionally is a potent activator of the inositol lipid cascade in PC12 cells, elevating the content of inositol phosphates by 8-fold at 10(-8) M (EC50 = 7 x 10(-9) M). Inositol 207-215 adenylate cyclase activating polypeptide 1 Rattus norvegicus 40-45 1312787-2 1992 Because vasoconstrictor hormones, such as angiotensin II, stimulate arteriolar smooth muscle and mesangial cell contraction via the D-myo-inositol (MI)-dependent transmembrane signaling pathway, in diabetes extracellular D-glucose may inhibit MI transport causing MI depletion, reduced signaling, and hypocontractility. Inositol 132-146 angiotensinogen Rattus norvegicus 42-56 1587797-1 1992 A dominant, single nuclear gene mutation, CSE1, caused inositol auxotrophy in yeast cells. Inositol 55-63 importin-alpha export receptor Saccharomyces cerevisiae S288C 42-46 1518180-7 1992 Inositol metabolism and Ca mobilization in response to thrombin, STA2, or NaF were also investigated in patient A,B, and impaired aggregation to A23187 in patient C. The responses were normal in patient A, suggested that CO activity did not affect them. Inositol 0-8 coagulation factor II, thrombin Homo sapiens 55-63 1518180-7 1992 Inositol metabolism and Ca mobilization in response to thrombin, STA2, or NaF were also investigated in patient A,B, and impaired aggregation to A23187 in patient C. The responses were normal in patient A, suggested that CO activity did not affect them. Inositol 0-8 C-X-C motif chemokine ligand 8 Homo sapiens 74-77 1737789-2 1992 The genomic structure and organization of a variant glycophorin allele specifying a novel Miltenberger (Mi)-related phenotype, MiX, were examined. Inositol 90-92 Mix paired-like homeobox Homo sapiens 127-130 1311564-3 1992 Addition of purified growth factors such as TGF-beta, EGF and FGF to these cells promoted inositol uptake and lead to an increase in the incorporation of [3H]inositol into phosphoinositides. Inositol 90-98 transforming growth factor, beta 1 Mus musculus 44-52 1311564-3 1992 Addition of purified growth factors such as TGF-beta, EGF and FGF to these cells promoted inositol uptake and lead to an increase in the incorporation of [3H]inositol into phosphoinositides. Inositol 90-98 epidermal growth factor Mus musculus 54-57 1311564-4 1992 Stimulation of inositol uptake by TGF-beta required at least a 24 hr exposure to the growth factor. Inositol 15-23 transforming growth factor, beta 1 Mus musculus 34-42 1309839-9 1992 These findings are consistent with a mediatory role for bradykinin in the action of kallikrein on decidua cells and suggest that inositol phospholipid hydrolysis is instrumental for arachidonic acid release in response to bradykinin in these cells. Inositol 129-137 kallikrein related peptidase 4 Homo sapiens 84-94 1309839-9 1992 These findings are consistent with a mediatory role for bradykinin in the action of kallikrein on decidua cells and suggest that inositol phospholipid hydrolysis is instrumental for arachidonic acid release in response to bradykinin in these cells. Inositol 129-137 kininogen 1 Homo sapiens 222-232 1370506-5 1992 On the other hand, aldose reductase inhibitors significantly reduced the sorbitol content and increased the cAMP and myoinositol contents in the sciatic nerves of diabetic rats. Inositol 117-128 aldo-keto reductase family 1 member B1 Rattus norvegicus 19-35 1370319-7 1992 In [3H]inositol-labeled cells, substance P induced a robust inositol phosphate formation. Inositol 7-15 tachykinin precursor 1 Homo sapiens 31-42 1309423-4 1992 EC significantly blocked the thrombin stimulated breakdown of phosphatidylinositol-4,5-bisphosphate (PIP2) and the production of phosphatidic acid in [32P]orthophosphate-labeled platelets and of inositol trisphosphate in [3H]myoinositol-labeled platelets. Inositol 225-236 coagulation factor II, thrombin Homo sapiens 29-37 1727737-4 1992 This study demonstrates that Mg2+ is a positive effector of inositol transport and is capable of promoting a 2.5-fold increase in the affinity of the transporter for inositol. Inositol 60-68 mucin 7, secreted Homo sapiens 29-32 1727737-4 1992 This study demonstrates that Mg2+ is a positive effector of inositol transport and is capable of promoting a 2.5-fold increase in the affinity of the transporter for inositol. Inositol 166-174 mucin 7, secreted Homo sapiens 29-32 1727737-5 1992 Analysis of the kinetics of inositol transport shows that, at physiological concentrations of inositol, the reductions in Mg2+ concentrations that occur in diabetic patients would result in a significant decline in the rate of inositol transport (1.5- to 2-fold). Inositol 28-36 mucin 7, secreted Homo sapiens 122-125 1727737-5 1992 Analysis of the kinetics of inositol transport shows that, at physiological concentrations of inositol, the reductions in Mg2+ concentrations that occur in diabetic patients would result in a significant decline in the rate of inositol transport (1.5- to 2-fold). Inositol 94-102 mucin 7, secreted Homo sapiens 122-125 1727737-5 1992 Analysis of the kinetics of inositol transport shows that, at physiological concentrations of inositol, the reductions in Mg2+ concentrations that occur in diabetic patients would result in a significant decline in the rate of inositol transport (1.5- to 2-fold). Inositol 94-102 mucin 7, secreted Homo sapiens 122-125 21043879-7 1992 With 50 nM PAF, the decrease in amount of extractable PIP(2) (1.09+-0.11 nmol/10(9) platelets) was not accounted for by an increase in the amount of PIP; the decrease in the amount of [(3)H]inositol label in PIP(2) in platelets stimulated in the presence of polymerising fibrin was accounted for by the sum of the increases in PIP labelling and the label associated with interfacial protein from the lipid extractions. Inositol 190-198 prolactin-inducible protein homolog Oryctolagus cuniculus 54-57 1765153-2 1991 In this study, we show that highly phosphorylated forms of inositol compete against the arrestin-rhodopsin interaction. Inositol 59-67 rhodopsin Homo sapiens 97-106 1819714-2 1991 PAF caused two types of contractions of coronary smooth muscle cells (SMC): (i) rapid, transient (phasic) contractions of SMC were induced by inositol 1,4,5-trisphosphate dependent Ca2+ release from sarcoplasmic reticulum (SR); (ii) slow sustained (tonic) contractions were induced by increase in Ca(2+)-sensitivity of the contractile apparatus of SMC by protein kinase C activation. Inositol 142-150 PCNA clamp associated factor Homo sapiens 0-3 1660262-1 1991 In order to identify the amino acid residues involved in calmodulin (CaM) binding and catalytic activity, rat brain inositol 1,4,5-trisphosphate (InsP3) 3-kinase was expressed in Escherichia coli as a beta-galactosidase fusion protein [clone C5; Takazawa, Vandekerckhove, Dumont & Erneux (1990) Biochem. Inositol 116-124 calmodulin 1 Rattus norvegicus 69-72 1954254-3 1991 The addition of choline to inositol-containing growth medium repressed the levels of CHO2 mRNA and OPI3 mRNA abundance in wild-type cells. Inositol 27-35 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 85-89 1954254-3 1991 The addition of choline to inositol-containing growth medium repressed the levels of CHO2 mRNA and OPI3 mRNA abundance in wild-type cells. Inositol 27-35 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 99-103 1954254-4 1991 The major effect on the levels of the CHO2 mRNA and OPI3 mRNA occurred in response to inositol. Inositol 86-94 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 38-42 1954254-4 1991 The major effect on the levels of the CHO2 mRNA and OPI3 mRNA occurred in response to inositol. Inositol 86-94 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 52-56 1954254-7 1991 CHO2 mRNA and OPI3 mRNA were regulated by inositol plus choline in opi3 and cho2 mutants, respectively. Inositol 42-50 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 0-4 1954254-7 1991 CHO2 mRNA and OPI3 mRNA were regulated by inositol plus choline in opi3 and cho2 mutants, respectively. Inositol 42-50 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 14-18 1954254-7 1991 CHO2 mRNA and OPI3 mRNA were regulated by inositol plus choline in opi3 and cho2 mutants, respectively. Inositol 42-50 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 67-71 1954254-7 1991 CHO2 mRNA and OPI3 mRNA were regulated by inositol plus choline in opi3 and cho2 mutants, respectively. Inositol 42-50 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 76-80 1954254-9 1991 This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway. Inositol 81-89 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 44-48 1954254-9 1991 This analysis showed that the regulation of CHO2 mRNA and OPI3 mRNA abundance by inositol required phosphatidylcholine synthesis by the CDP-choline-based pathway. Inositol 81-89 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 58-62 1657670-0 1991 Diminished specific activity of cytosolic protein kinase C in sciatic nerve of streptozocin-induced diabetic rats and its correction by dietary myo-inositol. Inositol 144-156 protein kinase C, gamma Rattus norvegicus 42-58 1657670-1 1991 The impaired Na(+)-K(+)-ATPase activity in peripheral nerve from diabetic rats is prevented by dietary myo-inositol (MI) supplementation in vivo and corrected by protein kinase C (PKC) agonists in vitro, suggesting that PKC may mediate the effects of nerve MI depletion on Na(+)-K(+)-ATPase activity. Inositol 103-115 protein kinase C, gamma Rattus norvegicus 220-223 1744575-2 1991 In human endometrial stromal cells, bombesin and bradykinin provoked an increase in intracellular free Ca2+ and in labelled inositol phosphates when pre-incubated with [3H]myoinositol. Inositol 172-183 gastrin releasing peptide Homo sapiens 36-44 1744575-2 1991 In human endometrial stromal cells, bombesin and bradykinin provoked an increase in intracellular free Ca2+ and in labelled inositol phosphates when pre-incubated with [3H]myoinositol. Inositol 172-183 kininogen 1 Homo sapiens 49-59 1681032-2 1991 Of 11 ligands tested, the addition of four, i.e., norepinephrine, oxotremorine-M, endothelin-1, and ATP, each resulted in an increased release (three- to eightfold) of inositol phosphates from [3H]inositol-prelabeled cells. Inositol 168-176 endothelin 1 Homo sapiens 82-94 1910817-4 1991 Analyses of hydrolytic products in BPAEC radiolabeled with [3H]myo-inositol and exposed to Cd2+ indicate that degradation of complex phospholipids is mediated by phospholipase A2. Inositol 63-75 LOC104974671 Bos taurus 162-178 1841813-0 1991 Effect of glucose and an aldose reductase inhibitor on myo-inositol uptake by cultured human endothelial cells. Inositol 55-67 aldo-keto reductase family 1 member B Homo sapiens 25-41 1936592-7 1991 The biological significance of insulin-dependent gly-Pl hydrolysis was demonstrated by insulin and inositol phosphoglycan regulation of glucose metabolism in intact lymphocytes. Inositol 99-107 insulin Homo sapiens 31-38 1936595-6 1991 Exposure of hRPE cells to 20-40 mM glucose produced time- and dose-dependent increases in sorbitol content and decreases in myo-inositol content that were partially blocked by the aldose reductase inhibitor sorbinil. Inositol 124-136 ribulose-5-phosphate-3-epimerase Homo sapiens 12-16 1936595-6 1991 Exposure of hRPE cells to 20-40 mM glucose produced time- and dose-dependent increases in sorbitol content and decreases in myo-inositol content that were partially blocked by the aldose reductase inhibitor sorbinil. Inositol 124-136 aldo-keto reductase family 1 member B Homo sapiens 180-196 1936595-9 1991 The impairment of rod outer segment uptake by high glucose levels was prevented by an aldose reductase inhibitor or elevated medium myo-inositol that corrected the fall in myo-inositol content. Inositol 172-184 aldo-keto reductase family 1 member B Homo sapiens 86-102 1936595-10 1991 Thus, hRPE cells provide a new in vitro model in which to examine the biochemical-functional interrelationships of the myo-inositol depletion hypothesis. Inositol 119-131 ribulose-5-phosphate-3-epimerase Homo sapiens 6-10 1924548-7 1991 The transcription of aldose reductase and the transport of betaine and inositol are regulated, dependent on the degree of hypertonicity. Inositol 71-79 aldo-keto reductase family 1 member B Homo sapiens 21-37 1654553-0 1991 Glycosyl-phosphatidylinositol/inositol phosphoglycan: a signaling system for the low-affinity nerve growth factor receptor. Inositol 21-29 nerve growth factor receptor Homo sapiens 81-122 1650825-6 1991 In [3H]myo-inositol labeled strips of myometrial smooth muscle, the adenosine agonist R-phenylisopropyl adenosine (R-PIA) stimulated the rapid formation of inositol-1,4,5-trisphosphate (InsP3) that was antagonized by addition of the nucleoside receptor antagonist 8-sulfophenyl theophylline. Inositol 7-19 ribose-5-phosphate isomerase Cavia porcellus 86-120 1650460-4 1991 Formation of the INO2/INO4-dependent complexes was increased when extracts prepared from cells grown under derepressing conditions (i.e. absence of inositol and choline). Inositol 148-156 Ino2p Saccharomyces cerevisiae S288C 17-21 1650460-4 1991 Formation of the INO2/INO4-dependent complexes was increased when extracts prepared from cells grown under derepressing conditions (i.e. absence of inositol and choline). Inositol 148-156 Ino4p Saccharomyces cerevisiae S288C 22-26 1888777-1 1991 Phosphatidylinositol (PI) is synthesized from cytidine-diphosphodiacylglycerol (CDP-DAG) and inositol by the enzyme PI synthase. Inositol 12-20 cut-like homeobox 1 Rattus norvegicus 80-83 1888777-1 1991 Phosphatidylinositol (PI) is synthesized from cytidine-diphosphodiacylglycerol (CDP-DAG) and inositol by the enzyme PI synthase. Inositol 12-20 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Rattus norvegicus 116-127 2040626-11 1991 The previously isolated myo-inositol transport mutant was determined to be defective in ITR1. Inositol 24-36 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 88-92 1646318-1 1991 Endothelin (ET)-1, -2, -3, big ET-1 and sarafotoxin S6b (S6b) dose-dependently increased phosphoinositide (PI) hydrolysis by 6- to 10-fold in cultured cerebellar granule cells prelabeled with [3H] myoinositol. Inositol 197-208 endothelin 1 Homo sapiens 31-35 1653632-4 1991 Concentrations of 1, 10 and 100 nM insulin significantly stimulated the accumulation of [3H]inositol phosphate ([3H]IP1) and [3H]IP2 in hippocampal slices labelled with [3H]myoinositol. Inositol 173-184 insulin Gallus gallus 35-42 1655286-3 1991 At the same time, a marked reduction of DNA polymerase alpha activity was observed, suggesting a possible involvement of nuclear inositol fraction in the response of the cell nucleus to interferon treatment. Inositol 129-137 DNA polymerase alpha 1, catalytic subunit Homo sapiens 40-60 2027776-5 1991 All INO1 fusion constructs that retained regulation in response to the phospholipid precursors inositol and choline, contained at least one copy of a nine bp repeated element (consensus, 5"-ATGTG-AAAT-3"). Inositol 95-103 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 2007563-2 1991 PLD and PI-PLC activities in these four transfected cell lines as well as in nontransfected cells were measured by the formation of [3H]phosphatidylethanol [( 3H]PEt) and [3H]inositol phosphates [( 3H]IP) after labeling cellular phospholipids with [3H]oleic acid and [3H]inositol. Inositol 175-183 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 0-3 2007563-2 1991 PLD and PI-PLC activities in these four transfected cell lines as well as in nontransfected cells were measured by the formation of [3H]phosphatidylethanol [( 3H]PEt) and [3H]inositol phosphates [( 3H]IP) after labeling cellular phospholipids with [3H]oleic acid and [3H]inositol. Inositol 175-183 phospholipase C epsilon 1 Homo sapiens 8-14 2004655-0 1991 Inositol derivatives down-regulate c-myc inducing growth arrest without differentiation. Inositol 0-8 MYC proto-oncogene, bHLH transcription factor Homo sapiens 35-40 2010046-6 1991 These data suggest that normalization of tissue myo-inositol metabolism restores normal responsiveness to angiotensin II; this may contribute to the reduction in GFR with the two experimental maneuvers. Inositol 48-60 angiotensinogen Rattus norvegicus 106-120 1672374-2 1991 Basal and thrombin-induced [3H]inositol monophosphate ([3H]IP1), [3H]inositol bisphosphate ([3H]IP2) and [3H]inositol trisphosphate ([3H]IP3) production were measured in [3H]myoinositol-labeled platelets in the presence of lithium chloride and in the presence or absence of test drugs. Inositol 174-185 coagulation factor II, thrombin Homo sapiens 10-18 1848440-4 1991 However, after stimulation of MNLs by concanavalin A, there was a significantly greater metabolism of inositol to inositol-1-phosphate (IP1) in the controls compared to the atopic MNLs; the mean percentage rise in the IP1 fraction over baseline level was 40% in the atopics, but almost 200% in controls after 2 h. Diminished inositol metabolism in atopic MNLs may explain the reduced cell-mediated immunity that characterizes the atopic state. Inositol 102-110 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 136-139 1848440-4 1991 However, after stimulation of MNLs by concanavalin A, there was a significantly greater metabolism of inositol to inositol-1-phosphate (IP1) in the controls compared to the atopic MNLs; the mean percentage rise in the IP1 fraction over baseline level was 40% in the atopics, but almost 200% in controls after 2 h. Diminished inositol metabolism in atopic MNLs may explain the reduced cell-mediated immunity that characterizes the atopic state. Inositol 102-110 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 218-221 1848440-4 1991 However, after stimulation of MNLs by concanavalin A, there was a significantly greater metabolism of inositol to inositol-1-phosphate (IP1) in the controls compared to the atopic MNLs; the mean percentage rise in the IP1 fraction over baseline level was 40% in the atopics, but almost 200% in controls after 2 h. Diminished inositol metabolism in atopic MNLs may explain the reduced cell-mediated immunity that characterizes the atopic state. Inositol 114-122 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 136-139 1650774-11 1991 Hence CATRTGAA was concluded to play an important role in the myo-inositol-choline regulation of PEM1 and PEM2. Inositol 62-74 phosphatidylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 97-101 1650774-11 1991 Hence CATRTGAA was concluded to play an important role in the myo-inositol-choline regulation of PEM1 and PEM2. Inositol 62-74 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 106-110 1824727-3 1991 Analyses of the signaling pathway showed that IL-2 stimulated the rapid hydrolysis of an inositol-containing glycolipid to yield two possible second messengers, a myristylated diacylglycerol and an inositol phosphate-glycan. Inositol 89-97 interleukin 2 Homo sapiens 46-50 1907924-6 1991 The accumulation of galactitol, intracellular vacuole formation and loss of myoinositol observed in D-galactose-exposed cells were prevented by the inclusion of the aldose reductase inhibitor, sorbinil, in the culture medium. Inositol 76-87 aldo-keto reductase family 1 member B Homo sapiens 165-181 1901824-0 1991 Restoration of myo-inositol uptake by aldose reductase inhibitor in human skin fibroblasts cultured in high-glucose medium. Inositol 15-27 aldo-keto reductase family 1 member B Homo sapiens 38-54 1812285-1 1991 Since inositol 1,4,5-trisphosphate (1,4,5-IP3) and inositol 1,3,4,5-tetrakisphosphate (1,3,4,5-IP4) have been described to modulate Ca(2+)-channels, we investigated the possible participation of 1,4,5-IP3 and/or 1,3,4,5-IP4 in the bradykinin-induced Ca(2+)-influx into cultured porcine aortic endothelial cells. Inositol 6-14 kininogen 1 Homo sapiens 231-241 2176165-0 1990 Ca2(+)-mobilising properties of synthetic fluoro-analogues of myo-inositol 1,4,5-trisphosphate and their interaction with myo-inositol 1,4,5-trisphosphate 3-kinase and 5-phosphatase. Inositol 62-74 carbonic anhydrase 2 Homo sapiens 0-3 2173922-4 1990 Soluble 5"-nucleotidase contained a similar quantity of myo-inositol, suggesting that it was previously membrane-anchored via glycosyl phosphatidylinositol. Inositol 56-68 5'-nucleotidase ecto Homo sapiens 8-23 2173922-5 1990 The form resistant to phosphatidylinositol-specific phospholipase C contained less myo-inositol, leaving open the possibility of a third form of 5"-nucleotidase with a conventional transmembrane anchor. Inositol 83-95 5'-nucleotidase ecto Homo sapiens 145-160 2280574-3 1990 Studying their behaviour under vasopressin treatment in diabetes insipidus rats and after insulin treatment in diabetes mellitus rats confirmed this conclusion: AVP led to a steady increase of sorbitol and glycerophosphorylcholine over 7 days with no effect on inositol levels. Inositol 261-269 arginine vasopressin Rattus norvegicus 161-164 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 108-116 thyrotropin releasing hormone Rattus norvegicus 34-63 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 108-116 thyrotropin releasing hormone Rattus norvegicus 65-68 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 118-121 thyrotropin releasing hormone Rattus norvegicus 34-63 2173558-1 1990 We report that there are distinct thyrotropin-releasing hormone (TRH)-responsive and -unresponsive pools of inositol (Ins) lipids in rat pituitary tumour (GH3) cells, and present evidence that the size of the responsive pool is determined by the number of activated TRH-receptor complexes. Inositol 118-121 thyrotropin releasing hormone Rattus norvegicus 65-68 2124193-5 1990 Although the addition of an aldose reductase inhibitor (0.7 mmol/l) to the hyperglycaemic culture media containing an additional 66.7 mmol/l glucose significantly reduced the sorbitol content of embryos to approximately one-eighth, the myo-inositol content of embryos remained decreased and the frequency of neural lesions was unchanged (23.1% vs 23.9%, NS). Inositol 236-248 aldo-keto reductase family 1 member B1 Rattus norvegicus 28-44 2174240-5 1990 The effect of TRH was concentration-dependent; half-maximal stimulation of alpha-MSH release and inositol incorporation occurred at 12 and 28 nmol TRH/l respectively. Inositol 97-105 thyrotropin releasing hormone Rattus norvegicus 14-17 2174240-5 1990 The effect of TRH was concentration-dependent; half-maximal stimulation of alpha-MSH release and inositol incorporation occurred at 12 and 28 nmol TRH/l respectively. Inositol 97-105 thyrotropin releasing hormone Rattus norvegicus 147-150 2167151-1 1990 In [3H]inositol-labeled membranes prepared from Swiss mouse 3T3 and human small cell lung carcinoma cells, [Tyr4]-bombesin stimulated production of water-soluble inositol phosphates. Inositol 7-15 gastrin releasing peptide Homo sapiens 114-122 2370888-1 1990 BACKGROUND AND METHODS: Inositol is a major component of the intracellular mediators of insulin action. Inositol 24-32 insulin Homo sapiens 88-95 2370888-9 1990 Furthermore, the chiro-inositol content of such preparations increased after the administration of insulin during euglycemic-hyperinsulinemic-clamp studies in normal subjects but not in patients with NIDDM: CONCLUSIONS: NIDDM is associated with decreased chiro-inositol excretion and decreased chiro-inositol content in muscle. Inositol 17-31 insulin Homo sapiens 99-106 2370888-9 1990 Furthermore, the chiro-inositol content of such preparations increased after the administration of insulin during euglycemic-hyperinsulinemic-clamp studies in normal subjects but not in patients with NIDDM: CONCLUSIONS: NIDDM is associated with decreased chiro-inositol excretion and decreased chiro-inositol content in muscle. Inositol 255-269 insulin Homo sapiens 99-106 2370888-9 1990 Furthermore, the chiro-inositol content of such preparations increased after the administration of insulin during euglycemic-hyperinsulinemic-clamp studies in normal subjects but not in patients with NIDDM: CONCLUSIONS: NIDDM is associated with decreased chiro-inositol excretion and decreased chiro-inositol content in muscle. Inositol 255-269 insulin Homo sapiens 99-106 1964638-5 1990 In slices obtained from APA, angiotensin II induced rapid increases in [3H]inositol and [45Ca] efflux, both of which preceded the aldosterone response. Inositol 75-83 angiotensinogen Homo sapiens 29-43 2142685-1 1990 The modulatory role of endogenous cellular glycosphingolipids in bradykinin-stimulated myo-inositol 1,4,5-trisphosphate (InsP3) formation by MDCK cells was evaluated utilizing the glucosylceramide synthase inhibitor, threo-1-phenyl-2-decanoylamino-3-morpholino-1-propanol (PDMP). Inositol 87-99 kininogen 1 Canis lupus familiaris 65-75 2169360-0 1990 Inositol phospholipid turnover and intracellular Ca2+ responses to thyrotrophin-releasing hormone, gonadotrophin-releasing hormone and arginine vasopressin in pituitary corticotroph and somatotroph adenomas. Inositol 0-8 thyrotropin releasing hormone Homo sapiens 67-97 2169360-0 1990 Inositol phospholipid turnover and intracellular Ca2+ responses to thyrotrophin-releasing hormone, gonadotrophin-releasing hormone and arginine vasopressin in pituitary corticotroph and somatotroph adenomas. Inositol 0-8 arginine vasopressin Homo sapiens 144-155 2161346-6 1990 These results suggest that thrombin uses the phospholipid-inositol pathway to counteract the morphological response, which was induced by activation of the cAMP pathway. Inositol 58-66 coagulation factor II Rattus norvegicus 27-35 2112545-1 1990 We have shown that there is an inositol (Ins) lipid pool in cloned rat pituitary tumor (GH3) cells that is hydrolyzed in response to thyrotropin-releasing hormone (TRH) and an unresponsive pool. Inositol 31-39 thyrotropin releasing hormone Rattus norvegicus 133-162 2112545-1 1990 We have shown that there is an inositol (Ins) lipid pool in cloned rat pituitary tumor (GH3) cells that is hydrolyzed in response to thyrotropin-releasing hormone (TRH) and an unresponsive pool. Inositol 41-44 thyrotropin releasing hormone Rattus norvegicus 133-162 1694260-6 1990 In the absence of photolyzed rhodopsin, both intact 2H3 and Fab fragments of 2H3 were able to inhibit completely, in a concentration-dependent manner, ADP-ribosylation of transducin by pertussis toxin 2H3 had no effect on ADP-ribosylation in the presence of photolyzed rhodopsin. Inositol 52-55 rhodopsin Bos taurus 269-278 1694260-6 1990 In the absence of photolyzed rhodopsin, both intact 2H3 and Fab fragments of 2H3 were able to inhibit completely, in a concentration-dependent manner, ADP-ribosylation of transducin by pertussis toxin 2H3 had no effect on ADP-ribosylation in the presence of photolyzed rhodopsin. Inositol 77-80 rhodopsin Bos taurus 269-278 1694260-7 1990 The GTPase activity of transducin, which is dependent on rhodopsin, was inhibited only 50% by 2H3. Inositol 94-97 rhodopsin Bos taurus 57-66 1694260-9 1990 Further, reactions of gamma with 2H3 appear to be prevented by interaction with rhodopsin, suggesting that its interaction either shields or alters the epitope recognized by 2H3. Inositol 33-36 rhodopsin Bos taurus 80-89 1694260-9 1990 Further, reactions of gamma with 2H3 appear to be prevented by interaction with rhodopsin, suggesting that its interaction either shields or alters the epitope recognized by 2H3. Inositol 174-177 rhodopsin Bos taurus 80-89 2341411-8 1990 Only small increases were induced by angiotensin II at 20 s. These data demonstrate that the accumulation of 1,2-diacylglycerol generated from inositol lipid breakdown is only observed with activation by angiotensin II. Inositol 143-151 angiotensinogen Rattus norvegicus 37-51 2341411-8 1990 Only small increases were induced by angiotensin II at 20 s. These data demonstrate that the accumulation of 1,2-diacylglycerol generated from inositol lipid breakdown is only observed with activation by angiotensin II. Inositol 143-151 angiotensinogen Rattus norvegicus 204-218 1692067-0 1990 Constitutive turnover of inositol-containing phospholipids in B220+ T cells from autoimmune-prone MRL-lpr/lpr mice. Inositol 25-33 Fas (TNF receptor superfamily member 6) Mus musculus 102-105 1692067-0 1990 Constitutive turnover of inositol-containing phospholipids in B220+ T cells from autoimmune-prone MRL-lpr/lpr mice. Inositol 25-33 Fas (TNF receptor superfamily member 6) Mus musculus 106-109 2160234-5 1990 Treatment of platelets for 1 min with PAF (2 nM) or thrombin (2 units/ml) led to the rapid hydrolysis of inositol-containing phospholipids, a 2-3-fold stimulation of both cytosolic and particulate-derived PKC activity, and platelet aggregation. Inositol 105-113 prothrombin Oryctolagus cuniculus 52-60 2185278-5 1990 Administration of an aldose reductase inhibitor prevented reductions in both nerve myo-inositol content and endoneurial sodium-dependent 2-aminoisobutyric acid uptake. Inositol 83-95 aldo-keto reductase family 1 member B1 Oryctolagus cuniculus 21-37 2185278-6 1990 Myo-inositol supplementation that produced a transient pharmacological elevation in plasma myo-inositol concentration, but did not raise nerve myo-inositol content, reproduced the effect of the aldose reductase inhibitor on endoneurial sodium-dependent 2-aminoisobutyric acid uptake. Inositol 0-12 aldo-keto reductase family 1 member B1 Oryctolagus cuniculus 194-210 2138615-12 1990 This paper shows that the single difference between P2 and P3, and the basis for the PI-PLC insusceptibility of P3, is a fatty acid, ester-linked to the inositol residue in P3. Inositol 153-161 phospholipase C beta 1 Homo sapiens 85-91 2155238-4 1990 An ino4 deletion mutant was constructed by in vitro gene disruption and the deletion mutant was shown to be viable but auxotrophic for inositol. Inositol 135-143 Ino4p Saccharomyces cerevisiae S288C 3-7 2178923-0 1990 Myoinositol gets incorporated into numerous membrane glycoproteins of Saccharomyces cerevisiae; incorporation is dependent on phosphomannomutase (sec53). Inositol 0-11 phosphomannomutase SEC53 Saccharomyces cerevisiae S288C 146-151 2406558-2 1990 At the permissive temperature, several of the mutants were inositol auxotrophs as a result of inadequate induction of INO1 transcription. Inositol 59-67 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 118-122 1691115-7 1990 The tachykinins substance P, 8-Tyr-substance P, physalaemin, neurokinin A, eledoisin, kassinin and neurokinin B induced receptor-mediated breakdown of [3H]inositol-labeled PIP2 in the membrane fraction in a concentration-dependent manner, but with different potencies. Inositol 155-163 tachykinin precursor 3 Rattus norvegicus 99-111 2306224-0 1990 Inositol is a constituent of detergent-solubilized immunoaffinity-purified rat liver 5"-nucleotidase. Inositol 0-8 5' nucleotidase, ecto Rattus norvegicus 85-100 2306224-1 1990 myo-Inositol analysis of detergent-solubilized immunoaffinity-purified rat liver 5"-nucleotidase showed the presence of 1 mol of myo-inositol/mol of enzyme monomer. Inositol 0-12 5' nucleotidase, ecto Rattus norvegicus 81-96 2306224-1 1990 myo-Inositol analysis of detergent-solubilized immunoaffinity-purified rat liver 5"-nucleotidase showed the presence of 1 mol of myo-inositol/mol of enzyme monomer. Inositol 129-141 5' nucleotidase, ecto Rattus norvegicus 81-96 2375793-6 1990 Free inositol content was highest in brain and lowest in skeletal muscle of CBL and db/db mice; diabetes or ETOH intake did not affect tissue inositol content. Inositol 5-13 Casitas B-lineage lymphoma Mus musculus 76-79 2136803-0 1990 Biallelic neutrophil Na-antigen system is associated with a polymorphism on the phospho-inositol-linked Fc gamma receptor III (CD16). Inositol 88-96 Fc gamma receptor IIIa Homo sapiens 127-131 2332144-3 1990 We studied the effect of myo-inositol on Ca2(+)-uptake activity in sarcoplasmic reticulum in diabetic animals. Inositol 25-37 carbonic anhydrase 2 Rattus norvegicus 41-44 1688565-3 1990 Thus, perturbation of CD5 by monoclonal antibody enhances the ability of the CD3-antigen receptor complex to couple to the inositol phospholipid pathway. Inositol 123-131 CD5 molecule Homo sapiens 22-25 2104641-4 1990 This decrease of myo-inositol content was partially prevented by co-incubation with aldose reductase inhibitor, sorbinil. Inositol 17-29 aldo-keto reductase family 1 member B1 Rattus norvegicus 84-100 2104641-9 1990 These data suggest that myo-inositol content of glomerular mesangial cells, which is reduced by high concentrations of glucose, is maintained by two processes: a glucose-sensitive but sorbitol-insensitive process, sodium-dependent myo-inositol uptake; and a sorbitol (aldose reductase) sensitive process, myo-Inositol depletion under high glucose condition may induce dysfunction of mesangial cells seen in diabetes. Inositol 24-36 aldo-keto reductase family 1 member B1 Rattus norvegicus 268-284 33813002-0 2021 Dual role of inositol-requiring enzyme 1alpha (IRE-1alpha) in Cd-induced apoptosis in human renal tubular epithelial cells: endoplasmic reticulum stress and STAT3 signaling activation. Inositol 13-21 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 47-57 33813002-0 2021 Dual role of inositol-requiring enzyme 1alpha (IRE-1alpha) in Cd-induced apoptosis in human renal tubular epithelial cells: endoplasmic reticulum stress and STAT3 signaling activation. Inositol 13-21 signal transducer and activator of transcription 3 Homo sapiens 157-162 33802742-2 2021 Studies have implicated the endoplasmic reticulum stress transducer inositol requiring enzyme 1alpha (IRE1alpha) in CF airway inflammation. Inositol 68-76 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 102-111 7925360-10 1994 Such observations support the idea that down-regulation of both the Hm1 receptor and its associated inositol-phospholipid-specific-phospholipase-C-linked G-proteins is produced by two sequential steps. Inositol 100-108 cholinergic receptor muscarinic 1 Homo sapiens 68-71 34492172-2 2022 In this study, we found that mutations causing upregulation of the cAMP-Protein Kinase A (PKA) pathway cause hypersensitivity to the defect of complex sphingolipid biosynthesis caused by repression of AUR1 encoding inositol phosphorylceramide synthase, whereas loss of PKA confers resistance to the defect. Inositol 215-223 inositol phosphorylceramide synthase Saccharomyces cerevisiae S288C 201-205 34562280-5 2022 GIT1 gene expression is controlled by nutrient balance, with phosphate or inositol starvation increasing GIT1 expression to stimulate GPI uptake. Inositol 74-82 Git1p Saccharomyces cerevisiae S288C 0-4 34562280-5 2022 GIT1 gene expression is controlled by nutrient balance, with phosphate or inositol starvation increasing GIT1 expression to stimulate GPI uptake. Inositol 74-82 Git1p Saccharomyces cerevisiae S288C 105-109 34562280-12 2022 Loss of Aly1 and Aly2 leads to increased incorporation of inositol label from (3 H)-inositol-labelled GPI into PI, confirming that internalized GPI influences PI balance and indicating a role for the alpha-arrestins in this regulation. Inositol 58-66 Aly1p Saccharomyces cerevisiae S288C 8-12 34562280-12 2022 Loss of Aly1 and Aly2 leads to increased incorporation of inositol label from (3 H)-inositol-labelled GPI into PI, confirming that internalized GPI influences PI balance and indicating a role for the alpha-arrestins in this regulation. Inositol 58-66 Aly2p Saccharomyces cerevisiae S288C 17-21 34562280-12 2022 Loss of Aly1 and Aly2 leads to increased incorporation of inositol label from (3 H)-inositol-labelled GPI into PI, confirming that internalized GPI influences PI balance and indicating a role for the alpha-arrestins in this regulation. Inositol 84-92 Aly1p Saccharomyces cerevisiae S288C 8-12 34562280-12 2022 Loss of Aly1 and Aly2 leads to increased incorporation of inositol label from (3 H)-inositol-labelled GPI into PI, confirming that internalized GPI influences PI balance and indicating a role for the alpha-arrestins in this regulation. Inositol 84-92 Aly2p Saccharomyces cerevisiae S288C 17-21 34936108-0 2022 SlFHY3 and SlHY5 act compliantly to enhance cold tolerance through the integration of myo-inositol and light signaling in tomato. Inositol 86-98 transcription factor HY5 Solanum lycopersicum 11-16 34936108-5 2022 SlFHY3 physically interacts with ELONGATED HYPOCOTYL5 (SlHY5) to promote the transcriptional activity of SlHY5 on MYO-INOSITOL-1-PHOSPHATE SYNTHASE 3 (SlMIPS3) and induce myo-inositol accumulation in tomato plants under cold stress. Inositol 171-183 transcription factor HY5 Solanum lycopersicum 55-60 34936108-6 2022 Disruption of SlHY5 and SlMIPS3 largely suppresses the cold tolerance of SlFHY3-overexpressing plants and myo-inositol accumulation in tomato. Inositol 106-118 transcription factor HY5 Solanum lycopersicum 14-19 34915841-1 2021 BACKGROUND: Phosphatidylinositol 4 phosphate 5-kinase (PIP5K) plays a key enzyme role in the inositol signal transduction system and has essential functions in plants in terms of growth, development, and stress responses. Inositol 93-101 phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Homo sapiens 12-53 34915841-1 2021 BACKGROUND: Phosphatidylinositol 4 phosphate 5-kinase (PIP5K) plays a key enzyme role in the inositol signal transduction system and has essential functions in plants in terms of growth, development, and stress responses. Inositol 93-101 phosphatidylinositol-5-phosphate 4-kinase type 2 gamma Homo sapiens 55-60 34618080-5 2021 The first reaction of lipid remodeling is the removal of the acyl chain from the inositol group by Bst1p (yeast) and Post-GPI Attachment to Proteins Inositol Deacylase 1 (PGAP1, mammals). Inositol 81-89 Bst1p Saccharomyces cerevisiae S288C 99-104 34192507-6 2021 Furthermore, hypercapnia activated the unfolded protein response (UPR) by promoting phosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) and treatment with a siRNA against IRE1alpha prevented the decrease of NKA-beta in the ER. Inositol 103-111 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 137-146 34808241-1 2022 The unfolded protein response is activated by UVB irradiation, but the role of a key mediator, inositol requiring enzyme 1a (IRE1alpha), is not clear. Inositol 95-103 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 125-134 34763665-1 2021 BACKGROUND: Several recent journal articles report that D-chiro-inositol (DCI), primarily known as insulin second messenger, influences steroidogenesis. Inositol 56-72 insulin Homo sapiens 99-106 34664059-3 2021 The ER stress sensors inositol requiring protein 1alpha (IRE1alpha), eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3, also called PERK), and activating transcription factor 6 (ATF6) constitute the three branches of UPR to resolve ER stress. Inositol 22-30 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 57-66 34664059-3 2021 The ER stress sensors inositol requiring protein 1alpha (IRE1alpha), eukaryotic translation initiation factor 2 alpha kinase 3 (EIF2AK3, also called PERK), and activating transcription factor 6 (ATF6) constitute the three branches of UPR to resolve ER stress. Inositol 22-30 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 69-126 34618077-4 2021 We show that 16-kDa gamma-zein significantly activates the INOSITOL REQUIRING ENZYME1/BASIC LEUCINE ZIPPER 60 (bZIP60) UPR branch-but not the bZIP28 branch or autophagy-leading to induction of major UPR-controlled genes that encode folding helpers that function inside the ER. Inositol 59-67 basic region/leucine zipper motif 60 Arabidopsis thaliana 111-117 34229060-4 2021 Preliminary studies showed that myo-Inositol inhibits the PI3K/Akt pathway by exerting a pleiotropic anti-tumor action. Inositol 32-44 AKT serine/threonine kinase 1 Homo sapiens 63-66 34075183-5 2021 Here, we review the biology of Inositol-requiring enzyme 1beta (IRE1beta), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1alpha. Inositol 31-39 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 64-72 34075183-5 2021 Here, we review the biology of Inositol-requiring enzyme 1beta (IRE1beta), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1alpha. Inositol 31-39 epiregulin Homo sapiens 78-80 34075183-5 2021 Here, we review the biology of Inositol-requiring enzyme 1beta (IRE1beta), an ER-resident endonuclease and paralogue of the most evolutionarily conserved ER stress sensor IRE1alpha. Inositol 31-39 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 171-180 34665453-1 2022 PURPOSE: To compare the effects of insulin sensitizers metformin (MET) and myo-inositol (MI) on adiponectin levels and metabolic characteristics in women with polycystic ovary syndrome (PCOS) with respect to their body mass index (BMI). Inositol 75-87 insulin Homo sapiens 35-42 34665453-1 2022 PURPOSE: To compare the effects of insulin sensitizers metformin (MET) and myo-inositol (MI) on adiponectin levels and metabolic characteristics in women with polycystic ovary syndrome (PCOS) with respect to their body mass index (BMI). Inositol 75-87 adiponectin, C1Q and collagen domain containing Homo sapiens 96-107 34710213-8 2021 Furthermore, this study demonstrates Inos mRNA regulation by dietary inositol; when more inositol is provided there is less Inos mRNA. Inositol 69-77 myo-inositol-1-phosphate synthase Drosophila melanogaster 37-41 34710213-8 2021 Furthermore, this study demonstrates Inos mRNA regulation by dietary inositol; when more inositol is provided there is less Inos mRNA. Inositol 89-97 myo-inositol-1-phosphate synthase Drosophila melanogaster 124-128 34624138-0 2021 Efficacy of Myo-inositol and D-chiro-inositol combination on menstrual cycle regulation and improving insulin resistance in young girls with PCOS: A randomized open-label study. Inositol 12-24 insulin Homo sapiens 102-109 34624138-0 2021 Efficacy of Myo-inositol and D-chiro-inositol combination on menstrual cycle regulation and improving insulin resistance in young girls with PCOS: A randomized open-label study. Inositol 29-45 insulin Homo sapiens 102-109 34624138-8 2021 CONCLUSION: Myo-inositol and D-chiro-inositol combination (3.6:1 ratio) is effective in regularising menstrual cycles and improving insulin resistance. Inositol 12-24 insulin Homo sapiens 132-139 34624138-8 2021 CONCLUSION: Myo-inositol and D-chiro-inositol combination (3.6:1 ratio) is effective in regularising menstrual cycles and improving insulin resistance. Inositol 29-45 insulin Homo sapiens 132-139 34675883-3 2021 Here, we found that the ER stress sensor inositol-requiring enzyme 1alpha (IRE1alpha) was activated in the Akita mice, a mouse model of mutant insulin gene-induced diabetes of youth (MIDY), a monogenic diabetes. Inositol 41-49 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 75-84 34680494-1 2021 D-chiro-inositol (DCI) is a natural compound detectable in cell membranes, which is highly conserved as a biological signaling molecule. Inositol 0-16 enoyl-CoA delta isomerase 1 Homo sapiens 18-21 34375928-2 2021 Increased expression of inducible nitric oxide synthase (iNOS) and dysfunction of the unfolded protein response (UPR), especially inositol-requiring enzyme 1alpha-X-box binding protein 1 (IRE1alpha-Xbp1s) signaling in the heart, have been associated with HFpEF. Inositol 130-138 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 188-197 34097282-8 2021 dACC myo-inositol was positively correlated with axial diffusivity in the left anterior corona radiata (p < 0.0001) in CON but not AUD (group effect: p < 0.001; region x group: p < 0.001; Bonferroni-corrected). Inositol 5-17 Acetyl-CoA carboxylase Drosophila melanogaster 0-4 34482916-9 2021 In addition, BraA.cax1a-4 presented increased osmotic protection through myo-inositol accumulation. Inositol 73-85 calnexin homolog 1 Brassica rapa 18-25 34560123-10 2021 Moreover, both inositol-requiring enzyme 1alpha (IRE1alpha) RNase and kinase inhibitor KIRA6 and IRE1alpha kinase inhibitor APY29 completely inhibited As2O3-induced GRP78 protein expression and phosphorylation of JNK, ERK and p38 MAPK. Inositol 15-23 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 49-58 34560123-10 2021 Moreover, both inositol-requiring enzyme 1alpha (IRE1alpha) RNase and kinase inhibitor KIRA6 and IRE1alpha kinase inhibitor APY29 completely inhibited As2O3-induced GRP78 protein expression and phosphorylation of JNK, ERK and p38 MAPK. Inositol 15-23 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 97-106 34560123-10 2021 Moreover, both inositol-requiring enzyme 1alpha (IRE1alpha) RNase and kinase inhibitor KIRA6 and IRE1alpha kinase inhibitor APY29 completely inhibited As2O3-induced GRP78 protein expression and phosphorylation of JNK, ERK and p38 MAPK. Inositol 15-23 heat shock protein family A (Hsp70) member 5 Homo sapiens 165-170 34560123-10 2021 Moreover, both inositol-requiring enzyme 1alpha (IRE1alpha) RNase and kinase inhibitor KIRA6 and IRE1alpha kinase inhibitor APY29 completely inhibited As2O3-induced GRP78 protein expression and phosphorylation of JNK, ERK and p38 MAPK. Inositol 15-23 mitogen-activated protein kinase 8 Homo sapiens 213-216 34560123-10 2021 Moreover, both inositol-requiring enzyme 1alpha (IRE1alpha) RNase and kinase inhibitor KIRA6 and IRE1alpha kinase inhibitor APY29 completely inhibited As2O3-induced GRP78 protein expression and phosphorylation of JNK, ERK and p38 MAPK. Inositol 15-23 mitogen-activated protein kinase 1 Homo sapiens 218-221 34579137-7 2021 Therefore, myo-inositol supplementation throughout lactation, alone and combined with leptin, reverts programmed alterations by fetal undernutrition on hypothalamic structure and gene expression of potential early biomarkers of metabolic health in PBMC, which might be attributed, in part, to increased leptin sensitivity. Inositol 11-23 leptin Rattus norvegicus 303-309 34355875-1 2021 Inositol requiring mutant 80 (INO80) is a chromatin remodeler that regulates pluripotency maintenance of embryonic stem cells and reprogramming of somatic cells into pluripotent stem cells. Inositol 0-8 INO80 complex ATPase subunit Homo sapiens 30-35 34531253-0 2022 SLC5A3-dependent myo-inositol auxotrophy in acute myeloid leukemia. Inositol 17-29 solute carrier family 5 member 3 Homo sapiens 0-6 34531253-3 2022 We demonstrate that SLC5A3 is essential to support a myo-inositol auxotrophy in AML. Inositol 53-65 solute carrier family 5 member 3 Homo sapiens 20-26 34531253-5 2022 We use gain- and loss-of-function experiments to reveal a synthetic lethal genetic interaction between ISYNA1 and SLC5A3 in AML, which function redundantly to sustain intracellular myo-inositol. Inositol 181-193 inositol-3-phosphate synthase 1 Homo sapiens 103-109 34531253-5 2022 We use gain- and loss-of-function experiments to reveal a synthetic lethal genetic interaction between ISYNA1 and SLC5A3 in AML, which function redundantly to sustain intracellular myo-inositol. Inositol 181-193 solute carrier family 5 member 3 Homo sapiens 114-120 34547240-0 2021 Inositol serves as a natural inhibitor of mitochondrial fission by directly targeting AMPK. Inositol 0-8 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 86-90 34547240-2 2021 Here, we show that inositol is a critical metabolite directly restricting AMPK-dependent mitochondrial fission independently of its classical mode as a precursor for phosphoinositide generation. Inositol 19-27 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 74-78 34547240-3 2021 Inositol decline by IMPA1/2 deficiency elicits AMPK activation and mitochondrial fission without affecting ATP level, whereas inositol accumulation prevents AMPK-dependent mitochondrial fission. Inositol 0-8 inositol monophosphatase 1 Homo sapiens 20-27 34547240-3 2021 Inositol decline by IMPA1/2 deficiency elicits AMPK activation and mitochondrial fission without affecting ATP level, whereas inositol accumulation prevents AMPK-dependent mitochondrial fission. Inositol 0-8 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 47-51 34547240-3 2021 Inositol decline by IMPA1/2 deficiency elicits AMPK activation and mitochondrial fission without affecting ATP level, whereas inositol accumulation prevents AMPK-dependent mitochondrial fission. Inositol 0-8 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 157-161 34547240-3 2021 Inositol decline by IMPA1/2 deficiency elicits AMPK activation and mitochondrial fission without affecting ATP level, whereas inositol accumulation prevents AMPK-dependent mitochondrial fission. Inositol 126-134 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 157-161 34547240-4 2021 Metabolic stress or mitochondrial damage causes inositol decline in cells and mice to elicit AMPK-dependent mitochondrial fission. Inositol 48-56 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 93-97 34547240-5 2021 Inositol directly binds to AMPKgamma and competes with AMP for AMPKgamma binding, leading to restriction of AMPK activation and mitochondrial fission. Inositol 0-8 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 108-112 34547240-6 2021 Our study suggests that the AMP/inositol ratio is a critical determinant for AMPK activation and establishes a model in which AMPK activation requires inositol decline to release AMPKgamma for AMP binding. Inositol 32-40 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 77-81 34547240-6 2021 Our study suggests that the AMP/inositol ratio is a critical determinant for AMPK activation and establishes a model in which AMPK activation requires inositol decline to release AMPKgamma for AMP binding. Inositol 32-40 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 126-130 34547240-6 2021 Our study suggests that the AMP/inositol ratio is a critical determinant for AMPK activation and establishes a model in which AMPK activation requires inositol decline to release AMPKgamma for AMP binding. Inositol 151-159 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 77-81 34547240-6 2021 Our study suggests that the AMP/inositol ratio is a critical determinant for AMPK activation and establishes a model in which AMPK activation requires inositol decline to release AMPKgamma for AMP binding. Inositol 151-159 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 126-130 34547240-7 2021 Hence, AMPK is an inositol sensor, whose inactivation by inositol serves as a mechanism to restrict mitochondrial fission. Inositol 18-26 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 7-11 34547240-7 2021 Hence, AMPK is an inositol sensor, whose inactivation by inositol serves as a mechanism to restrict mitochondrial fission. Inositol 57-65 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 7-11 34309066-9 2021 Myo-inositol was associated with amyloid, tau, and neurodegeneration markers, mainly at symptomatic stages of the disease, whereas N-acetyl-aspartate was related to neurodegeneration biomarkers in symptomatic stages. Inositol 0-12 microtubule associated protein tau Homo sapiens 42-45 34571697-6 2021 Significant increases were measured in inositol-requiring enzyme 1-alpha (IRE1-alpha) and binding immunoglobulin protein 90 (GRP90) levels as well as mRNA expression levels of caspase 3, 4 and 9 genes indicating enhanced ER stress. Inositol 39-47 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 74-84 34502057-4 2021 In pathogenesis, cereulide exposure activated endoplasmic reticulum stress (ER stress) via the pathways of inositol-requiring enzyme 1alpha (IRE1alpha)/Xbox binding protein (XBP1) and PRKR-like ER kinase (PERK)/eukaryotic translation initiation factor 2alpha (eIF2alpha), and consequently led to the apoptosis and tissue damages in mouse liver and kidney. Inositol 107-115 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 141-150 34502057-4 2021 In pathogenesis, cereulide exposure activated endoplasmic reticulum stress (ER stress) via the pathways of inositol-requiring enzyme 1alpha (IRE1alpha)/Xbox binding protein (XBP1) and PRKR-like ER kinase (PERK)/eukaryotic translation initiation factor 2alpha (eIF2alpha), and consequently led to the apoptosis and tissue damages in mouse liver and kidney. Inositol 107-115 X-box binding protein 1 Mus musculus 174-178 34407601-10 2021 Inhibition of inositol-requiring enzyme 1 alpha (IRE1alpha), the most conserved signaling branch in ER stress, reduced GVHD development in mice. Inositol 14-22 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 49-58 34407851-0 2021 Comparative efficacy of oral insulin sensitizers metformin, thiazolidinediones, inositol, and berberine in improving endocrine and metabolic profiles in women with PCOS: a network meta-analysis. Inositol 80-88 insulin Homo sapiens 29-36 34407851-1 2021 BACKGROUND: Multiple oral insulin-sensitizing agents, such as metformin, thiazolidinediones, inositols, and berberine, have been proven safe and efficacious in improving the endocrine, metabolic, and reproductive abnormalities seen in polycystic ovary syndrome (PCOS), providing more options for healthcare providers and patients. Inositol 93-102 insulin Homo sapiens 26-33 34407851-11 2021 Thiazolidinediones, metformin + thiazolidinediones, and myo-inositol + D-chiro-inositol were associated with a lower insulin resistance index (HOMA-IR) compared with that in metformin alone (mean differences: - 0.72 (95% CI (- 1.11)-(- 0.34)) to - 0.89 (95% CI (- 1.460)-(- 0.32))). Inositol 56-68 insulin Homo sapiens 117-124 34407851-11 2021 Thiazolidinediones, metformin + thiazolidinediones, and myo-inositol + D-chiro-inositol were associated with a lower insulin resistance index (HOMA-IR) compared with that in metformin alone (mean differences: - 0.72 (95% CI (- 1.11)-(- 0.34)) to - 0.89 (95% CI (- 1.460)-(- 0.32))). Inositol 71-87 insulin Homo sapiens 117-124 34407851-13 2021 CONCLUSIONS: Ours is the first study to report that for women with PCOS, myo-inositol combined with D-chiro-inositol and metformin combined with thiazolidinediones appear superior to metformin alone in improving insulin resistance and decreasing total testosterone. Inositol 73-85 insulin Homo sapiens 212-219 34407851-13 2021 CONCLUSIONS: Ours is the first study to report that for women with PCOS, myo-inositol combined with D-chiro-inositol and metformin combined with thiazolidinediones appear superior to metformin alone in improving insulin resistance and decreasing total testosterone. Inositol 100-116 insulin Homo sapiens 212-219 34087214-7 2021 Except myo-inositol, all polyols decreased RGS L106R aggregation, with carbohydrates exerting the strongest inhibition. Inositol 7-19 paired like homeodomain 2 Homo sapiens 43-46 34439531-7 2021 In addition, other natural molecules, myo-inositol (MI) and d-chiro-inositol (DCI), ameliorate sperm quality. Inositol 60-76 enoyl-CoA delta isomerase 1 Homo sapiens 78-81 34444908-6 2021 Inositols and vitamin D supplementation, as well as micronutrients (zinc, chromium, magnesium) and pre/probiotics, result in modest improvement in insulin sensitivity, but their use is not systematically suggested. Inositol 0-9 insulin Homo sapiens 147-154 34368469-8 2021 Inositol requiring enzyme-1 alpha (IRE1alpha) was not activated; but hypoxia induced eif2alpha phosphorylation, increasing expression of ATF4 (activating transcription factor-4). Inositol 0-8 activating transcription factor 4 Homo sapiens 137-141 34335474-2 2021 Obesity and insulin resistance, caused by a high-fat diet, eventually result in severe metabolic diseases, can be prevented with the dietary supplement D-chiro-inositol (DCI). Inositol 152-168 enoyl-Coenzyme A delta isomerase 1 Mus musculus 170-173 34191474-2 2021 They are highly regulated through a network of distinct phosphatidylinositol phosphates consisting of seven groups and three regioisomers in two groups (PIP and PIP2), which arise from phosphorylation at 3", 4", and 5" positions of the inositol ring. Inositol 236-244 prolactin induced protein Homo sapiens 153-156 34295814-2 2021 Inositol requiring enzyme 1 alpha (IRE1alpha), a key regulator of unfolded protein response (UPR), is intimately associated with PCa progression. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 35-44 34337729-3 2021 In the last years, among the insulin sensitizers, the use of the two active isoforms of inositols (myo-inositol and d-chiro-inositol) has been spreading for the treatment of PCOS insulin resistance. Inositol 88-97 insulin Homo sapiens 29-36 34199095-1 2021 Myo-inositol (Myo) improves insulin resistance, glucose metabolism, and helps gestational diabetes (GDM) management. Inositol 0-12 insulin Homo sapiens 28-35 34169781-7 2022 Furthermore, his studies allowed to improve the inositol"s efficacy using alpha-lactalbumin. Inositol 48-56 lactalbumin alpha Homo sapiens 74-91 34107246-6 2021 Higher-order oligomerization of the inositol-requiring enzyme 1alpha (IRE1alpha) kinase/endoribonuclease depends upon RAC. Inositol 36-44 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 70-79 34070701-5 2021 In fact, myo-ins participates in several signaling processes, including the pathways of insulin and gonadotropins, and, therefore, it is likely to positively affect fertility. Inositol 9-16 insulin Homo sapiens 88-95 34093381-0 2021 Down-Regulation of Inpp5e Associated With Abnormal Ciliogenesis During Embryonic Neurodevelopment Under Inositol Deficiency. Inositol 104-112 inositol polyphosphate-5-phosphatase E Mus musculus 19-25 34093381-11 2021 The expression levels of Inpp5e gene and the PtdIns (3,4) P2 levels were also significantly decreased in the inositol deficient cell model. Inositol 109-117 inositol polyphosphate-5-phosphatase E Mus musculus 25-31 34345856-8 2021 Molecular docking based studies showed the plausible binding of two significant wheatgrass constituents, i.e., apigenin and myo-inositol with COX-2 protein, with binding energies of -10.59 kcal/mol and -7.88 kcal/mol, respectively. Inositol 124-136 cytochrome c oxidase II, mitochondrial Mus musculus 142-147 34180421-7 2021 We have recently discovered that mesencephalic astrocyte-derived neurotrophic factor (MANF) exerts its prosurvival action in dopamine neurons and in animal model of PD through the direct binding to UPR sensor inositol-requiring protein 1 alpha (IRE1alpha) and attenuation of UPR. Inositol 209-217 mesencephalic astrocyte derived neurotrophic factor Homo sapiens 33-84 34180421-7 2021 We have recently discovered that mesencephalic astrocyte-derived neurotrophic factor (MANF) exerts its prosurvival action in dopamine neurons and in animal model of PD through the direct binding to UPR sensor inositol-requiring protein 1 alpha (IRE1alpha) and attenuation of UPR. Inositol 209-217 mesencephalic astrocyte derived neurotrophic factor Homo sapiens 86-90 34180421-7 2021 We have recently discovered that mesencephalic astrocyte-derived neurotrophic factor (MANF) exerts its prosurvival action in dopamine neurons and in animal model of PD through the direct binding to UPR sensor inositol-requiring protein 1 alpha (IRE1alpha) and attenuation of UPR. Inositol 209-217 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 245-254 35175495-13 2022 Moreover, silencing of inositol requiring enzyme 1 alpha (IRE1alpha) blocked the effects of IMD inhibiting fibroblast and NLRP3 activation. Inositol 23-31 adrenomedullin 2 Rattus norvegicus 92-95 35175495-13 2022 Moreover, silencing of inositol requiring enzyme 1 alpha (IRE1alpha) blocked the effects of IMD inhibiting fibroblast and NLRP3 activation. Inositol 23-31 NLR family, pyrin domain containing 3 Rattus norvegicus 122-127 35247568-7 2022 Knockout of ISYNA1 (encoding myo-inositol-3-P synthase 1) in HEK293T cells generated a human cell line that is deficient in de novo inositol synthesis. Inositol 132-140 inositol-3-phosphate synthase 1 Homo sapiens 12-18 35247568-7 2022 Knockout of ISYNA1 (encoding myo-inositol-3-P synthase 1) in HEK293T cells generated a human cell line that is deficient in de novo inositol synthesis. Inositol 132-140 inositol-3-phosphate synthase 1 Homo sapiens 29-56 35247568-8 2022 ISYNA1-KO cells exhibited inositol-less death when deprived of inositol. Inositol 26-34 inositol-3-phosphate synthase 1 Homo sapiens 0-6 35247568-8 2022 ISYNA1-KO cells exhibited inositol-less death when deprived of inositol. Inositol 63-71 inositol-3-phosphate synthase 1 Homo sapiens 0-6 35247568-10 2022 RNA-Seq analysis revealed that inositol deprivation induced substantial changes in the expression of genes involved in cell signaling, including extracellular signal-regulated kinase (ERK), and genes controlling amino acid transport and protein processing in the endoplasmic reticulum (ER). Inositol 31-39 mitogen-activated protein kinase 1 Homo sapiens 145-182 35247568-10 2022 RNA-Seq analysis revealed that inositol deprivation induced substantial changes in the expression of genes involved in cell signaling, including extracellular signal-regulated kinase (ERK), and genes controlling amino acid transport and protein processing in the endoplasmic reticulum (ER). Inositol 31-39 mitogen-activated protein kinase 1 Homo sapiens 184-187 35304860-2 2022 Inositol-requiring enzyme 1alpha (IRE1alpha) mediates chaperone production and autophagy during ER stress. Inositol 0-8 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 34-43 35243728-8 2022 Myo-inositol treatment resulted in positive modulation of PINK1/Parkin pathway as well as PHB2 and NIX. Inositol 0-12 PTEN induced kinase 1 Rattus norvegicus 58-63 35243728-8 2022 Myo-inositol treatment resulted in positive modulation of PINK1/Parkin pathway as well as PHB2 and NIX. Inositol 0-12 prohibitin 2 Rattus norvegicus 90-94 35243728-8 2022 Myo-inositol treatment resulted in positive modulation of PINK1/Parkin pathway as well as PHB2 and NIX. Inositol 0-12 BCL2 interacting protein 3 like Rattus norvegicus 99-102 35243728-9 2022 Myo-inositol also enhanced the mitochondrial biogenesis in renal tissue of diabetic rat by upregulating Nrf2/SIRT1/PGC-1alpha axis. Inositol 0-12 NFE2 like bZIP transcription factor 2 Rattus norvegicus 104-108 35243728-9 2022 Myo-inositol also enhanced the mitochondrial biogenesis in renal tissue of diabetic rat by upregulating Nrf2/SIRT1/PGC-1alpha axis. Inositol 0-12 sirtuin 1 Rattus norvegicus 109-114 35243728-9 2022 Myo-inositol also enhanced the mitochondrial biogenesis in renal tissue of diabetic rat by upregulating Nrf2/SIRT1/PGC-1alpha axis. Inositol 0-12 PPARG coactivator 1 alpha Rattus norvegicus 115-125 35347633-5 2022 There was a reduction in N-acetylaspartylglutamate level, and elevation in myo-inositol in the spinal cord of female and male SOD1G37R mice. Inositol 75-87 superoxide dismutase 1, soluble Mus musculus 126-130 35258157-4 2022 SlIMP3 demonstrated high affinity with the L-Gal 1-P and D-Ins 3-P, and acted as a bifunctional enzyme in the biosynthesis of AsA and myoinositol. Inositol 134-145 inositol monophosphatase 3 Solanum lycopersicum 0-6 35258157-5 2022 Overexpression of SlIMP3 not only improved AsA and myoinositol content, but also increased cell wall thickness, improved fruit firmness, delayed fruit softening, decreased water loss, and extended shelf-life. Inositol 51-62 inositol monophosphatase 3 Solanum lycopersicum 18-24 35619328-2 2022 Here, it is demonstrated that the WEE1 inhibitor AZD1775 induces endoplasmic reticulum stress and activates the protein kinase RNA-like ER kinase (PERK) and inositol-required enzyme 1alpha (IRE1alpha) branches of the unfolded protein response (UPR) in TP53 mutant (mtTP53) ovarian cancer models. Inositol 157-165 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 190-199 35619328-2 2022 Here, it is demonstrated that the WEE1 inhibitor AZD1775 induces endoplasmic reticulum stress and activates the protein kinase RNA-like ER kinase (PERK) and inositol-required enzyme 1alpha (IRE1alpha) branches of the unfolded protein response (UPR) in TP53 mutant (mtTP53) ovarian cancer models. Inositol 157-165 tumor protein p53 Homo sapiens 252-256 35626128-3 2022 Under ER stress, the UPR tries to maintain cellular homeostasis through different pathways, including the inositol-requiring enzyme 1 alpha (IRE1alpha)-dependent ones. Inositol 106-114 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 141-150 35626002-10 2022 Ribosome profiling reveals genes involved in insulin signaling, glucose metabolism, and the inositol pathway to be the relevant translational targets of 4EBP1. Inositol 92-100 eukaryotic translation initiation factor 4E binding protein 1 Homo sapiens 153-158 35571237-6 2022 Mechanistically, miR-150-5p could bind with the 3"-untranslated region (UTR) of inositol requiring enzyme 1alpha (IRE1alpha), while IRE1alpha overexpression obliterated the impacts of miR-150-5p. Inositol 80-88 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 114-123 35571237-6 2022 Mechanistically, miR-150-5p could bind with the 3"-untranslated region (UTR) of inositol requiring enzyme 1alpha (IRE1alpha), while IRE1alpha overexpression obliterated the impacts of miR-150-5p. Inositol 80-88 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 132-141 35417272-3 2022 Increased brain myoinositol and altered functional-connectivity have been found in diabetes, mild cognitive impairment and Alzheimer"s disease, but the independent effects of plasma glucose and insulin on brain myoinositol and function are not characterized. Inositol 211-222 insulin Homo sapiens 194-201 35417272-7 2022 Lower myoinositol was associated with higher functional connectivity of the thalamus and precentral cortex with insula-ACC-related networks, suggesting myoinositol is involved in insulin-modulation of cognitive/emotional network function in healthy adults. Inositol 152-163 insulin Homo sapiens 179-186 35626276-3 2022 We recently reported the clinical performance of a new eGFR equation (GFRNMR) based on the nuclear magnetic resonance (NMR) measurement of serum myo-inositol, valine, and creatinine, in addition to the immunoturbidometric quantification of serum cystatin C, age and sex. Inositol 145-157 epidermal growth factor receptor Homo sapiens 55-59 35477841-2 2022 Many studies have reported improvement in insulin resistance and thereby intracellular glucose uptake after myo-inositol treatment in PCOS patients, but these studies have a small sample size, varying methodology, and outcome analysis. Inositol 108-120 insulin Homo sapiens 42-49 35625730-11 2022 In conclusion, PA treatment induced ER stress and activated the inositol-requiring enzyme 1 alpha-spliced XBP1 (IRE1alpha-XBP1s) pathway. Inositol 64-72 X-box binding protein 1 Homo sapiens 106-110 35625730-11 2022 In conclusion, PA treatment induced ER stress and activated the inositol-requiring enzyme 1 alpha-spliced XBP1 (IRE1alpha-XBP1s) pathway. Inositol 64-72 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 112-127 35462605-2 2022 Inositol and its derivatives exhibit tumor-suppressive effects, potentially mediated by inhibition of the ERK-MAPK or PI3K-Akt pathways. Inositol 0-8 mitogen-activated protein kinase 1 Homo sapiens 106-109 35462605-2 2022 Inositol and its derivatives exhibit tumor-suppressive effects, potentially mediated by inhibition of the ERK-MAPK or PI3K-Akt pathways. Inositol 0-8 AKT serine/threonine kinase 1 Homo sapiens 123-126 35462605-3 2022 Accordingly, many cancers have been documented to silence expression of the ISYNA1 gene, which encodes the rate-limiting enzyme of inositol synthesis. Inositol 131-139 inositol-3-phosphate synthase 1 Homo sapiens 76-82 35462605-7 2022 The role of inositol in cancer is further complicated by its ability to inhibit the master metabolic regulator AMPK, which upon activation can either decrease cell proliferation and metastasis or promote cell survival. Inositol 12-20 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 111-115 35412316-0 2022 Deprotonation from an OH on myo-Inositol Promoted by mu2-Bridges with Possible Regioselectivity/Chiral Selectivity. Inositol 28-40 adaptor related protein complex 1 subunit mu 2 Homo sapiens 53-56 35412316-1 2022 Single-crystal structures of myo-inositol complexes with erbium ((Er2(C6H11O6)2(H2O)5Cl2)Cl2(H2O)4, denoted ErI hereafter) and strontium (Sr(C6H12O6)2(H2O)2Cl2, denoted SrI hereafter) are described. Inositol 29-41 sorcin Homo sapiens 169-172 35379745-2 2022 Here we demonstrated that the EP4-mediated activation of AKT by PGE2 was required for the proper control of inositol-requiring transmembrane kinase endoribonuclease-1alpha (IRE1alpha) hyperactivation and hence the endoplasmic reticulum (ER) homeostasis in IgM-producing SLPCs. Inositol 108-116 prostaglandin E receptor 4 (subtype EP4) Mus musculus 30-33 35379745-2 2022 Here we demonstrated that the EP4-mediated activation of AKT by PGE2 was required for the proper control of inositol-requiring transmembrane kinase endoribonuclease-1alpha (IRE1alpha) hyperactivation and hence the endoplasmic reticulum (ER) homeostasis in IgM-producing SLPCs. Inositol 108-116 thymoma viral proto-oncogene 1 Mus musculus 57-60 35379745-2 2022 Here we demonstrated that the EP4-mediated activation of AKT by PGE2 was required for the proper control of inositol-requiring transmembrane kinase endoribonuclease-1alpha (IRE1alpha) hyperactivation and hence the endoplasmic reticulum (ER) homeostasis in IgM-producing SLPCs. Inositol 108-116 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 173-182 35474814-0 2022 Brain Metabolite, Myo-inositol, Inhibits Catalase Activity: A Mechanism of the Distortion of the Antioxidant Defense System in Alzheimer"s disease. Inositol 18-30 catalase Homo sapiens 41-49 35503642-10 2022 d-chiro-inositol is an insulin second messenger with insulin sensitizing and mimetic properties, recently described as an aromatase down-regulator. Inositol 0-16 insulin Homo sapiens 23-30 35503642-10 2022 d-chiro-inositol is an insulin second messenger with insulin sensitizing and mimetic properties, recently described as an aromatase down-regulator. Inositol 0-16 insulin Homo sapiens 53-60 35073444-6 2022 Myo-inositol, in quantities that is present in FPP, significantly improved macrophage respiratory burst and phagocytosis via de novo synthesis pathway of ISYNA1. Inositol 0-12 inositol-3-phosphate synthase 1 Homo sapiens 154-160 35465159-2 2022 The Inositol requiring enzyme 1alpha (IRE1alpha) is the most evolutionary conserved transducer of the UPR. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 38-47 35331172-7 2022 Five out of the 10 metabolites were up-regulated in the anti-TPO antibodies positivity group, including D-Glucose, L-Glutamine, 3-Hydroxybutyric acid, Myo-Inositol, Creatinine. Inositol 151-163 thyroid peroxidase Homo sapiens 61-64 35371155-0 2022 Inositol Improves Cold Tolerance Through Inhibiting CBL1 and Increasing Ca2+ Influx in Rapeseed (Brassica napus L.). Inositol 0-8 calcineurin B-like protein 1 Brassica napus 52-56 35371155-9 2022 Furthermore, we found that the expression of calcineurin B-like (CBL1) gene was inhibited by inositol. Inositol 93-101 calcineurin B-like protein 1 Brassica napus 65-69 35371155-11 2022 Moreover, the overexpression of BnCBL1-2 in Arabidopsis represented that transgenic plants mediated the Ca2+ flux highlighting the vital role of the inositol-Ca2+ pathway in conferring cold stress. Inositol 149-157 calcineurin B-like protein 1 Brassica napus 32-40 35277398-10 2022 HOMA-IR and serum insulin levels were lower in the myo-inositol vs placebo arm (mean difference -0.6, 95% CI -1.2 to 0.0 and -2.69, 95% CI -5.26 to -0.18, respectively). Inositol 51-63 insulin Homo sapiens 18-25 35277398-16 2022 There is a signal for efficacy in reducing insulin resistance in pregnancy with myo-inositol. Inositol 80-92 insulin Homo sapiens 43-50 35074429-6 2022 Since IRS1/2 requires membrane translocation and binding to inositol compounds for normal functions, we also examined the role of acetylation on binding to phosphatidylinositol(4,5)P2, and found that IRS1/2 acetylation by P300 reduced this binding. Inositol 60-68 insulin receptor substrate 1 Homo sapiens 200-206 35236761-0 2022 Myo-inositol for insulin resistance, metabolic syndrome, polycystic ovary syndrome and gestational diabetes. Inositol 0-12 insulin Homo sapiens 17-24 35157758-7 2022 Considerable metabolic heterogeneity outside of the mutated IDH pathway were also evident, with key metabolites being high expression of glycerophosphates, inositols, monosaccharides and sugar alcohols and low levels of sphingosine and lysoglycerophospholipids in IDH-mutants. Inositol 156-165 isocitrate dehydrogenase (NADP(+)) 1 Homo sapiens 60-63 35472446-1 2022 INTRODUCTION: Myo-inositol (MI) and d-chiro-inositol (DCI) play a key role in ovarian physiology, as they are second messengers of insulin and gonadotropins. Inositol 14-26 insulin Homo sapiens 131-138 35472446-1 2022 INTRODUCTION: Myo-inositol (MI) and d-chiro-inositol (DCI) play a key role in ovarian physiology, as they are second messengers of insulin and gonadotropins. Inositol 36-52 insulin Homo sapiens 131-138 35048325-9 2022 Furthermore, there existed a positive correlation between the NAA/Cr ratio and the NeuN protein expression (R = 0.496 p < 0.001 IHC; R = 0.568 p < 0.001 WB), the same results existed in the relationship between the mI/Cr ratio and the GFAP protein expression (R = 0.338 p = 0.019 IHC; R = 0.440 p = 0.002 WB). Inositol 215-217 RNA binding fox-1 homolog 3 Rattus norvegicus 83-87 35017615-5 2022 Mainly the inositol-requiring enzyme 1alpha branch of the UPR was upregulated as shown by elevated X-box binding-protein 1 (XBP1u) and its spliced isoform (XBP1s) mRNA (p < 0.05, respectively). Inositol 11-19 X-box binding protein 1 Homo sapiens 99-122 2557328-7 1989 The inositol also contained a mixture of fatty acids (16:0, 18:0, 18:1, 20:4, 22:0) located on a site other than the C2 position since the FBP was susceptible to PI-PLC cleavage. Inositol 4-12 folate receptor beta Homo sapiens 139-142 2557328-7 1989 The inositol also contained a mixture of fatty acids (16:0, 18:0, 18:1, 20:4, 22:0) located on a site other than the C2 position since the FBP was susceptible to PI-PLC cleavage. Inositol 4-12 phospholipase C beta 1 Homo sapiens 162-168 2695165-5 1989 The stearic acid label is removed by phospholipase D whereupon the protein with the retained inositol label is released from the membrane. Inositol 93-101 phospholipase D Saccharomyces cerevisiae S288C 37-52 2556641-7 1989 Furthermore, we show that activation of the CSF-1 receptor results in the accumulation in intact cells of polyphosphoinositides phosphorylated at the D-3 position of the inositol ring. Inositol 170-178 colony stimulating factor 1 receptor Homo sapiens 44-58 2558572-7 1989 The results demonstrate that ET activates the inositol lipid signaling pathway and induces mobilization of Ca2+ from both extra- and intracellular pools and activation of protein kinase C in osteoblastic MC3T3-E1 cells. Inositol 46-54 endothelin 1 Mus musculus 29-31 2693207-9 1989 The srb2 delta 10 mutants are temperature-sensitive, cold-sensitive and are inositol auxotrophs. Inositol 76-84 Srb2p Saccharomyces cerevisiae S288C 4-8 2553489-1 1989 Using [3H]-inositol-labeled human lymphocytes, formation of inositolphosphates was found as a specific response to the chemotactic formylpeptide, N-formyl-methionyl-leucyl-phenylalanine (fMLP), in a fashion similar to the effects of fMLP in human granulocytes. Inositol 11-19 formyl peptide receptor 1 Homo sapiens 187-191 2553489-1 1989 Using [3H]-inositol-labeled human lymphocytes, formation of inositolphosphates was found as a specific response to the chemotactic formylpeptide, N-formyl-methionyl-leucyl-phenylalanine (fMLP), in a fashion similar to the effects of fMLP in human granulocytes. Inositol 11-19 formyl peptide receptor 1 Homo sapiens 233-237 2505676-1 1989 Incubation of rabbit platelets with thrombin resulted in rapid accumulations of inositol trisphosphate (IP3) in [3H]inositol-labeled platelets, increases of [3H]arachidonic acid [( 3H]AA) release, and [3H]serotonin secretion from the platelets prelabeled with these labeled compounds. Inositol 80-88 prothrombin Oryctolagus cuniculus 36-44 2806431-6 1989 Both the reduced IP3 formation and DNA synthesis which were induced by high glucose were significantly reversed by adding either myo-inositol or AL1576, an aldose reductase inhibitor (ARI). Inositol 129-141 aldose reductase Bos taurus 156-172 2551276-2 1989 The dose response is similar to angiogenin activation of the inositol-specific phospholipase C in this cell line [Moore, F. & Riordan, J.F. Inositol 61-69 angiogenin Rattus norvegicus 32-42 2551384-1 1989 Addition of thyrotropin-releasing hormone (TRH) (10 nM to 10 microM) to bovine anterior pituitary cells labelled with [3H]inositol decreased the radioactivity in inositol-containing lipids and increased it in inositol phosphates. Inositol 122-130 thyrotropin releasing hormone Bos taurus 12-41 2551384-1 1989 Addition of thyrotropin-releasing hormone (TRH) (10 nM to 10 microM) to bovine anterior pituitary cells labelled with [3H]inositol decreased the radioactivity in inositol-containing lipids and increased it in inositol phosphates. Inositol 122-130 thyrotropin releasing hormone Bos taurus 43-46 2547768-1 1989 In adrenal glomerulosa cells, angiotensin II (AII) rapidly stimulates the formation of inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) and causes marked long-term changes in the levels of highly phosphorylated inositols. Inositol 206-215 angiotensinogen Homo sapiens 30-44 2547768-1 1989 In adrenal glomerulosa cells, angiotensin II (AII) rapidly stimulates the formation of inositol 1,4,5-trisphosphate (Ins-1,4,5-P3) and causes marked long-term changes in the levels of highly phosphorylated inositols. Inositol 206-215 angiotensinogen Homo sapiens 46-49 2752519-0 1989 Inositol and inositol hexaphosphate suppress cell proliferation and tumor formation in CD-1 mice. Inositol 0-8 CD1 antigen complex Mus musculus 87-91 2498332-5 1989 Both TRH and CCH caused sustained modest (to 210-280 nM) elevations of [Ca2+]i which were inhibited by voltage-sensitive channel-blocking agents and stimulated sustained hydrolysis of inositol lipids. Inositol 184-192 thyrotropin releasing hormone Mus musculus 5-8 2565843-4 1989 In the presence of guanosine 5"-triphosphate, furthermore, secretin enhanced adenylate cyclase activation in the membranes from these cells, and this activation was reduced by somatostatin, whereas neither secretin nor somatostatin affected inositol phospholipid turnover. Inositol 241-249 secretin Homo sapiens 59-67 2670666-0 1989 Mutations in the Saccharomyces cerevisiae opi3 gene: effects on phospholipid methylation, growth and cross-pathway regulation of inositol synthesis. Inositol 129-137 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 42-46 2670666-10 1989 A secondary effect of opi3 mutations is disruption of the cross pathway regulation of the synthesis of the PI (phosphatidylinositol) precursor inositol. Inositol 123-131 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 22-26 2670666-11 1989 Synthesis of inositol is controlled through regulation of the INO1 gene which encodes inositol-1-phosphate synthase. Inositol 13-21 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 62-66 2542281-8 1989 In other experiments, cell preloaded with [3H]inositol were treated with GnRH agonist ligand and phorbol ester at 4 degrees C to form a pool of sequestered, agonist-occupied receptors, and then displaceable (nonsequestered) agonist was removed by incubation with antagonist ligand. Inositol 46-54 gonadotropin releasing hormone 1 Homo sapiens 73-77 2526652-2 1989 Freeze-drying of trehalose, lactose, and myo-inositol with lysozyme resulted in substantial alterations of the infrared spectra of the dried carbohydrates. Inositol 41-53 lysozyme C-like Oryctolagus cuniculus 59-67 2543367-7 1989 We suggest that the effect of cholera toxin and agents which increase intracellular cyclic AMP on vasopressin-stimulated inositol lipid hydrolysis is an effect on receptor number, and that there is no requirement to postulate a role for a novel G-protein, which is a substrate for cholera toxin, in the regulation of inositol phospholipid metabolism. Inositol 121-129 arginine vasopressin Homo sapiens 98-109 2500357-9 1989 Together these findings suggest that vacuole formation and altered cell proliferation were caused by polyol accumulation and/or myo-inositol loss, both of which result from aldose reductase activity. Inositol 128-140 aldo-keto reductase family 1 member B1 Canis lupus familiaris 173-189 2539976-5 1989 1) In islets labeled for 2 h with [3H]inositol in the presence of 2.75 mM glucose, subsequent perifusion with 5.0 nM IL-1 increased insulin output, [3H]inositol efflux, and [3H]inositol phosphate accumulation in the simultaneous presence of 7 mM, but not 2.75 mM, glucose. Inositol 38-46 interleukin 1 alpha Homo sapiens 117-121 2540255-7 1989 The rise in [Ca2+]i induced by fMLP in 1,25-(OH)2D3-treated U937 cells was blocked by pertussis toxin and presumably mediated by inositol (1,4,5)-trisphosphate generation. Inositol 129-139 formyl peptide receptor 1 Homo sapiens 31-35 2538419-13 1989 Subsequently, a decrease in inositol lipid pools and PI kinase activity results in heterologous desensitization in response to AVP, thrombin, and ATP. Inositol 28-36 coagulation factor II Rattus norvegicus 132-140 2540962-3 1989 The resistance is due to the existence of an additional fatty acyl chain on the inositol ring which blocks the action of PtdIns-specific PLC [Roberts et al. Inositol 80-88 heparan sulfate proteoglycan 2 Homo sapiens 137-140 2538463-1 1989 Full expression of gelsolin-inhibiting function by polyphosphoinositides in vesicular form and inactivation by dilution, aggregation, or masking of the inositol head group. Inositol 152-160 gelsolin Homo sapiens 19-27 2929366-1 1989 Formation of inositol phosphates in response to carbachol, phenylephrine and vasoactive intestinal polypeptide (VIP) was studied after labelling with [3H]myo-inositol in rat submandibular gland fragments. Inositol 154-166 vasoactive intestinal peptide Rattus norvegicus 77-110 2929366-1 1989 Formation of inositol phosphates in response to carbachol, phenylephrine and vasoactive intestinal polypeptide (VIP) was studied after labelling with [3H]myo-inositol in rat submandibular gland fragments. Inositol 154-166 vasoactive intestinal peptide Rattus norvegicus 112-115 2495019-9 1989 Thrombin-mediated membrane inositol metabolism and total thrombin binding to endothelium were unaffected by lupus anticoagulant, and another endothelial anticoagulant function related thrombin binding. Inositol 27-35 coagulation factor II, thrombin Homo sapiens 0-8 2538812-3 1989 We have investigated the involvement of a newly identified inositol-containing glycolipid in signal transduction for the actions of NGF. Inositol 59-67 nerve growth factor Rattus norvegicus 132-135 2537149-4 1989 All strains containing suppressor mutations in RPB1 and RPB2 have reduced transcription of the INO1 gene and an inositol requirement. Inositol 112-120 RNA polymerase II subunit B Bos taurus 56-60 2536720-6 1989 Since rCGRP also accelerated the rate of synthesis of [3H]inositol-containing lipids, it appears that the peptide acts by stimulating phosphoinositide turnover in chick myotubes. Inositol 58-66 calcitonin-related polypeptide alpha Rattus norvegicus 6-11 2492022-15 1989 We subsequently examined the effect of a family of growth factors linked to inositol lipid hydrolysis and found that thrombin, like FGF, would increase [3H]thymidine incorporation and block CK synthesis. Inositol 76-84 coagulation factor II Mus musculus 117-125 2536048-1 1989 Elevated cellular sorbitol levels resulting from conversion of increased glucose by aldose reductase might deplete cellular myoinositol content, which could then lower inositol phosphates (InsPs) and diacylglycerol levels, key regulators of protein kinase C (PKC). Inositol 124-135 aldose reductase Bos taurus 84-100 2613862-6 1989 We interpret these data to mean that 1) in contrast to the findings with some cell lines, alterations in inositol lipid metabolism may be part of the signalling mechanism for EGF in embryonic cells; 2) EGF is capable of activating inositol-dependent signalling pathways leading to activation of protein kinase C in MEPM cells; and 3) mobilization and metabolism of arachidonic acid are not an inherent part of this signalling mechanism. Inositol 105-113 epidermal growth factor Mus musculus 175-178 2613862-6 1989 We interpret these data to mean that 1) in contrast to the findings with some cell lines, alterations in inositol lipid metabolism may be part of the signalling mechanism for EGF in embryonic cells; 2) EGF is capable of activating inositol-dependent signalling pathways leading to activation of protein kinase C in MEPM cells; and 3) mobilization and metabolism of arachidonic acid are not an inherent part of this signalling mechanism. Inositol 105-113 epidermal growth factor Mus musculus 202-205 2613862-6 1989 We interpret these data to mean that 1) in contrast to the findings with some cell lines, alterations in inositol lipid metabolism may be part of the signalling mechanism for EGF in embryonic cells; 2) EGF is capable of activating inositol-dependent signalling pathways leading to activation of protein kinase C in MEPM cells; and 3) mobilization and metabolism of arachidonic acid are not an inherent part of this signalling mechanism. Inositol 231-239 epidermal growth factor Mus musculus 202-205 2491899-7 1989 The changes in myo-inositol metabolism and content and sorbitol levels mediated by glucose exposure were blocked by addition of the aldose reductase inhibitor, sorbinil, to the media, suggesting that these changes are caused by the accumulation of sorbitol by the cells. Inositol 15-27 aldose reductase Bos taurus 132-148 2848806-1 1988 Palmitoylation of inositol results in resistance to phosphatidylinositol-specific phospholipase C. The glycoinositol phospholipid membrane anchor of human erythrocyte acetylcholinesterase (EC 3.1.1.7) contains a novel inositol phospholipid which in this and the accompanying paper (Roberts, W.L., Santikarn, S., Reinhold, V.N., and Rosenberry, T.L. Inositol 18-26 acetylcholinesterase (Cartwright blood group) Homo sapiens 167-187 2851976-4 1988 Insulin provoked rapid, sizeable, increases in the inositol-labelling of this lipid (presumably a PI-glycan), and these increases were similar to those observed in PI and PI phosphates. Inositol 51-59 insulin Homo sapiens 0-7 2849551-5 1988 Finally, we demonstrate that both PGE2 and dBcAMP inhibit the generation of inositol metabolites after T cell activation, thus indicating that these reagents interfere with early signal transduction mechanisms which precede the synthesis of IL 2R. Inositol 76-84 interleukin 2 receptor subunit alpha Homo sapiens 241-246 3246281-4 1988 The findings suggest a possible role of the inositol pathway in transmission of hormonal signal (vasopressin) to hypertensive rats" vessel smooth muscles as well as participation of vasopressin in pathogenesis of arterial hypertension and the possibility of using lithium oxybutyrate for its correction. Inositol 44-52 arginine vasopressin Rattus norvegicus 97-108 2855596-1 1988 Two chemically characterized peptides, arginine vasopressin (AVP) and corticotrophin-releasing factor-41 (CRF-41), known to stimulate ACTH secretion by interaction with their respective specific receptors on the corticotroph, were shown to cause the accumulation of phosphate esters of inositol (IP) and adenosine 3",5"-monophosphate (cAMP) respectively when added to rat anterior pituitary fragments incubated in vitro. Inositol 286-294 arginine vasopressin Rattus norvegicus 39-65 2846829-5 1988 In the [3]myoinositol labeled RBL-1 cells, LTD4 and LTE4 induced a rapid hydrolysis of [3H]phosphoinositides. Inositol 10-21 RB transcriptional corepressor like 1 Rattus norvegicus 30-35 2850468-5 1988 In cho2 and opi3 mutants, which are blocked in phosphatidylcholine synthesis, inositol-mediated repression of PGPS did not occur unless choline was added to the media. Inositol 78-86 bifunctional phosphatidyl-N-methylethanolamine N-methyltransferase/phosphatidyl-N-dimethylethanolamine N-methyltransferase Saccharomyces cerevisiae S288C 12-16 2850468-8 1988 PGPS expression in the opi1 mutant, which exhibits constitutive synthesis of general phospholipid biosynthetic enzymes, was fully repressed in the presence of inositol and partially repressed even in the absence of inositol. Inositol 159-167 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 23-27 2850468-8 1988 PGPS expression in the opi1 mutant, which exhibits constitutive synthesis of general phospholipid biosynthetic enzymes, was fully repressed in the presence of inositol and partially repressed even in the absence of inositol. Inositol 215-223 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 23-27 3190673-3 1988 The treatment of cells with angiotensin II under conditions where the maximal stimulation of inositol-lipid hydrolysis was observed did not cause a statistically significant change in the apparent subcellular distribution of protein kinase C. However, when the cytosolic extract was prepared in the presence of Ca2+ the protein kinase C activity was recovered nearly exclusively from the particulate fraction. Inositol 93-101 angiotensinogen Rattus norvegicus 28-42 2846297-4 1988 The thrombin-induced enhancement of inositol phospholipid metabolism was strongly inhibited by the presence of neomycin whereas the TPA- or ionomycin-induced increase in inositol [32P]polyphospholipids remained unaffected. Inositol 170-180 coagulation factor II, thrombin Homo sapiens 4-12 2844608-2 1988 Because 5"-nucleotidase is anchored to the membrane through inositol-containing phospholipid glycans, we investigated whether insulin could release the enzyme from the membrane. Inositol 60-68 5' nucleotidase, ecto Rattus norvegicus 8-23 2843607-0 1988 Stimulation of inositol incorporation into lipids of PC12 cells by nerve growth factor and bradykinin. Inositol 15-23 nerve growth factor Rattus norvegicus 67-86 2843607-3 1988 About 15 h of incubation with NGF and greater than 10 min of incubation with BK were needed for maximal stimulation of inositol incorporation by BK. Inositol 119-127 nerve growth factor Rattus norvegicus 30-33 2843607-5 1988 After incubation for 20 h with NGF, an increased binding of [3H]BK to the PC12 (+) cells was observed at 4 degrees C. Exposure of the cells for 30 min to 25 mM LiCl enhanced the effect of BK on the inositol incorporation into total inositol lipids, especially in PC12(+) cells. Inositol 198-206 nerve growth factor Rattus norvegicus 31-34 3419518-4 1988 The mas oncogene shows the greatest sequence similarity to the substance-K receptor, and on this basis it was predicted that it would encode a peptide receptor with mitogenic activity which would act through the inositol lipid signalling pathways. Inositol 212-220 tachykinin receptor 2 Homo sapiens 63-83 2842340-4 1988 This was confirmed by metabolic incorporation into CEA of 3H-labeled compounds such as ethanolamine, myo-inositol, palmitic acid, and stearic acid. Inositol 101-113 CEA cell adhesion molecule 3 Homo sapiens 51-54 3410839-3 1988 Further, chemical analyses of the inositol and phosphate content of the soluble form of dopamine beta-hydroxylase indicate that the enzyme contains no covalently attached phosphate or inositol. Inositol 34-42 dopamine beta-hydroxylase Bos taurus 88-113 2901964-2 1988 Activation of human T lymphocytes via the CD2 molecule produces an enhanced turnover of phosphatidylinositol (PI) cycle-related phospholipids accompanied by the increased production of diacylglycerol (DG) and phosphorylated derivatives of inositol (IP). Inositol 100-108 CD2 molecule Homo sapiens 42-45 2847980-0 1988 Role of inositol starvation on ecto-5"-nucleotidase activity during mitogen-induced lymphocyte activation. Inositol 8-16 5'-nucleotidase ecto Homo sapiens 31-51 2975507-2 1988 Chemical analysis of highly purified Drosophila AChE demonstrated approximately one residue of inositol per enzyme subunit. Inositol 95-103 Acetylcholine esterase Drosophila melanogaster 48-52 3189800-1 1988 Accumulation of sorbitol or galactitol and depletion of myo-inositol in hyperglycemic conditions such as diabetes and galactosemia involve the activity of aldose reductase and are implicated in hyperglycemia-induced complications such as cataract and neuropathy. Inositol 56-68 aldo-keto reductase family 1 member B1 Rattus norvegicus 155-171 3134894-12 1988 Taken collectively, the data show that the TMQ isomers interfered with the endoperoxide/thromboxane A2 receptor-mediated phospholipase C-signal cascade of inositol phospholipid hydrolysis, calcium mobilization, and protein phosphorylation leading to platelet aggregation and secretion. Inositol 155-163 thromboxane A2 receptor Homo sapiens 88-111 2839622-5 1988 The aldose reductase inhibitor sorbinil prevented the abnormalities in myo-inositol metabolism and partially restored Na+/K+-pump activity in neuroblastoma cells cultured in the presence of elevated glucose levels. Inositol 71-83 aldo-keto reductase family 1 member B Homo sapiens 4-20 2850246-3 1988 The site of action of GPA is at the TRH-induced hydrolysis of phosphoinositides, since increased amounts of mono, bis and tris/tetrakis inositol phosphates were found in treated cells, while the PRL secretion induced by a phorbol ester or a calcium ionophore, treatments which mimic the second messages generated by inositol phospholipid hydrolysis, were not enhanced by GPA. Inositol 136-144 thyrotropin releasing hormone Rattus norvegicus 36-39 2457905-0 1988 Angiogenin activates endothelial cell phospholipase C. Low concentrations of angiogenin activate the inositol-specific phospholipase C of cultured pulmonary artery, umbilical vein, and capillary endothelial cells, promoting a transient increase in the intracellular levels of 1,2-diacylglycerol and inositol trisphosphate. Inositol 101-109 angiogenin Homo sapiens 0-10 2457905-0 1988 Angiogenin activates endothelial cell phospholipase C. Low concentrations of angiogenin activate the inositol-specific phospholipase C of cultured pulmonary artery, umbilical vein, and capillary endothelial cells, promoting a transient increase in the intracellular levels of 1,2-diacylglycerol and inositol trisphosphate. Inositol 101-109 angiogenin Homo sapiens 77-87 3139540-5 1988 The results suggest that myo-inositol uptake by erythrocytes may be dependent on the active transport system via sodium-ATPase and that erythrocytes may not be a suitable model to monitor the possible effect of an aldose reductase inhibitor on myo-inositol concentrations in other tissues concerned with diabetic complications. Inositol 25-37 dynein axonemal heavy chain 8 Homo sapiens 120-126 3260903-3 1988 In [3H]myoinositol-labeled cells, both thrombin (3 U/ml)- and histamine (10(-4) M)-induced IP3 increases (195% +/- 6% and 98% +/- 4%, respectively) occurred in less than 15 sec and were temporally correlated with [Ca2+]i increases. Inositol 7-18 coagulation factor II, thrombin Homo sapiens 39-47 3138977-14 1988 It is concluded that the EGF-dependent pattern of stimulation is different from that observed in bradykinin-stimulated A431 cells, suggesting that there are separate mechanisms of inositol-lipid hydrolysis involved. Inositol 180-188 epidermal growth factor Homo sapiens 25-28 2838351-1 1988 Alterations in myo-inositol and phosphoinositide metabolism, induced by hyperglycemia and prevented by aldose reductase inhibitors, are implicated in impaired Na+-K+-ATPase regulation in peripheral nerve and other tissues prone to diabetic complications by an increasing range of scientific observations. Inositol 15-27 aldo-keto reductase family 1 member B Homo sapiens 103-119 3147829-5 1988 Prior treatment of the animals with insulin or with the aldose reductase inhibitor, sorbinil also resulted in an increase in myo-inositol uptake in streptozotocin diabetic nerve preparations. Inositol 125-137 aldo-keto reductase family 1, member B3 (aldose reductase) Mus musculus 56-72 2845165-1 1988 Incubation of [3H] inositol-labeled cultured rat aortic vascular smooth muscle cells with angiotensin II caused the dose- and time-dependent formation of inositol mono-, bis- and trisphosphates. Inositol 19-27 angiotensinogen Rattus norvegicus 90-104 3259133-6 1988 Simultaneous analysis of inositol-labeled phospholipids showed that the initial IP3 and DAG peaks corresponded to initial decreases in phosphoinositides PIP2 and PIP whereas PI increased slightly over this same time period. Inositol 25-33 prolactin induced protein Homo sapiens 153-156 2451665-8 1988 Ethylene glycol, glucose, sucrose, or myoinositol can substitute for glycerol with preservation of ATPase activity for several weeks in the presence of 20 mM Ca2+.Ca2+-induced association between ATPase molecules may be an essential requirement for preservation of enzymatic activity, both in intact sarcoplasmic reticulum and in solubilized preparations. Inositol 38-49 dynein axonemal heavy chain 8 Homo sapiens 99-105 2451665-8 1988 Ethylene glycol, glucose, sucrose, or myoinositol can substitute for glycerol with preservation of ATPase activity for several weeks in the presence of 20 mM Ca2+.Ca2+-induced association between ATPase molecules may be an essential requirement for preservation of enzymatic activity, both in intact sarcoplasmic reticulum and in solubilized preparations. Inositol 38-49 dynein axonemal heavy chain 8 Homo sapiens 196-202 2832385-1 1988 A Saccharomyces cerevisiae mutant (cdg1 mutation) was isolated on the basis of an inositol excretion phenotype and exhibited pleiotropic deficiencies in phospholipid biosynthesis. Inositol 82-90 phosphatidate cytidylyltransferase Saccharomyces cerevisiae S288C 35-39 2830280-7 1988 However, when PDB pretreatment was carried out in the presence of 0.3 microM GnRH, residual enhancement of Buserelin binding, but not antagonist binding, was observed at either 23 or 4 degrees C. The radiolabeled agonist activated, and the antagonist blocked, GnRH receptor-mediated luteinizing hormone release and [3H]inositol phosphate production in cells preloaded with [3H]inositol. Inositol 319-327 gonadotropin releasing hormone 1 Homo sapiens 77-81 3125044-2 1988 In rat granulosa cells prelabeled with [3H]AA or [3H]inositol, treatment with LHRH stimulates the accumulation of radiolabeled inositol phosphosphates, diacyglycerol, and unesterified AA. Inositol 53-61 gonadotropin releasing hormone 1 Rattus norvegicus 78-82 2828545-0 1988 5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in the mouse cortex has pharmacological characteristics compatible with mediation via 5-HT2 receptors but this response does not reflect altered 5-HT2 function after 5,7-dihydroxytryptamine lesioning or repeated antidepressant treatments. Inositol 31-39 hypothermia due to alcohol sensitivity 2 Mus musculus 152-155 2829912-13 1988 59, 353-366 (1977)] inhibit the stimulation by vasopressin of inositol utilization without significantly affecting coupling between hormone receptors and adenyl cyclase or phosphoinositide-specific phosphodiesterase, the action of the phosphodiesterase, and the degradation of inositol triphosphate. Inositol 62-70 arginine vasopressin Homo sapiens 47-58 2834106-1 1988 Yeast ino4 mutants are auxotrophic for the phospholipid precursor inositol and have pleiotropic defects in phospholipid synthesis. Inositol 66-74 Ino4p Saccharomyces cerevisiae S288C 6-10 2901161-9 1988 Metabolism of 1,4,5-IP3 to inositol proceeds via two distinct pathways in PMNs: (1) degradation to 1,4-IP2 and 4-IP1 or (2) conversion to 1,3,4,5-IP4, 1,3,4-IP3, 3,4-IP2 and 3-IP1. Inositol 27-35 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 103-106 2901161-9 1988 Metabolism of 1,4,5-IP3 to inositol proceeds via two distinct pathways in PMNs: (1) degradation to 1,4-IP2 and 4-IP1 or (2) conversion to 1,3,4,5-IP4, 1,3,4-IP3, 3,4-IP2 and 3-IP1. Inositol 27-35 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 113-116 2901161-9 1988 Metabolism of 1,4,5-IP3 to inositol proceeds via two distinct pathways in PMNs: (1) degradation to 1,4-IP2 and 4-IP1 or (2) conversion to 1,3,4,5-IP4, 1,3,4-IP3, 3,4-IP2 and 3-IP1. Inositol 27-35 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 166-169 2901161-9 1988 Metabolism of 1,4,5-IP3 to inositol proceeds via two distinct pathways in PMNs: (1) degradation to 1,4-IP2 and 4-IP1 or (2) conversion to 1,3,4,5-IP4, 1,3,4-IP3, 3,4-IP2 and 3-IP1. Inositol 27-35 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 176-179 2826256-3 1987 We have now tested the specificity of various nucleotides in regulating PIC activity in the absence or presence of the hormone cholecystokinin (CCK-8) in saponin-permeabilized [3H]inositol-labelled Flow 9000 cells. Inositol 180-188 phospholipase C beta 1 Homo sapiens 72-75 3500949-11 1987 The observation that pertussis toxin selectively abolishes EGF-stimulated inositol lipid breakdown suggests that EGF and angiotensin II use different mechanisms to activate phospholipase C in hepatocytes. Inositol 74-82 epidermal growth factor Rattus norvegicus 113-116 3500949-11 1987 The observation that pertussis toxin selectively abolishes EGF-stimulated inositol lipid breakdown suggests that EGF and angiotensin II use different mechanisms to activate phospholipase C in hepatocytes. Inositol 74-82 epidermal growth factor Rattus norvegicus 59-62 3500949-11 1987 The observation that pertussis toxin selectively abolishes EGF-stimulated inositol lipid breakdown suggests that EGF and angiotensin II use different mechanisms to activate phospholipase C in hepatocytes. Inositol 74-82 angiotensinogen Rattus norvegicus 121-135 3451798-10 1987 Vasopressin increased the hydrolysis of inositol-containing phospholipids in the ganglion and also increased the labeling of the 83,000 Mr protein. Inositol 40-48 arginine vasopressin Rattus norvegicus 0-11 2827166-5 1987 The expression of functionally active receptors for angiotensin II (AII) and thyrotropin-releasing hormone (TRH) was demonstrated by the stimulation of [3H]inositol phosphate production by AII and TRH in the mRNA-injected, [3H]inositol-prelabeled oocytes. Inositol 156-164 thyrotropin-releasing hormone L homeolog Xenopus laevis 77-106 2827166-5 1987 The expression of functionally active receptors for angiotensin II (AII) and thyrotropin-releasing hormone (TRH) was demonstrated by the stimulation of [3H]inositol phosphate production by AII and TRH in the mRNA-injected, [3H]inositol-prelabeled oocytes. Inositol 156-164 thyrotropin-releasing hormone L homeolog Xenopus laevis 108-111 2827166-5 1987 The expression of functionally active receptors for angiotensin II (AII) and thyrotropin-releasing hormone (TRH) was demonstrated by the stimulation of [3H]inositol phosphate production by AII and TRH in the mRNA-injected, [3H]inositol-prelabeled oocytes. Inositol 156-164 thyrotropin-releasing hormone L homeolog Xenopus laevis 197-200 2449164-0 1987 Direct measurement of inositol in bovine myelin basic protein. Inositol 22-30 myelin basic protein Bos taurus 41-61 3435437-2 1987 [3H]Inositol-prelabelled isolated rat adrenal glomerulosa cells were stimulated with 25 nM-AII ([Asp1, Ile5]-angiotensin II) in the presence of 10 mM-Li+, and the resulting inositol monophosphate isomers were separated successfully by using a recently developed h.p.l.c. Inositol 4-12 angiotensinogen Rattus norvegicus 109-123 3119709-8 1987 All glycerol-derived cell membrane phospholipids examined (phosphatidylethanolamine, -inositol, -choline, and -serine) incorporated labeled AA which was releasable by treatment with PLA2. Inositol 86-94 phospholipase A2, group IB, pancreas Mus musculus 182-186 2889598-9 1987 The sample of (2H3)methylmalonyl-CoA was incubated in unlabelled buffer with a mixture of methylmalonyl-CoA mutase, epimerase and coenzyme B12. Inositol 15-18 methylmalonyl-CoA mutase Homo sapiens 90-114 2958239-6 1987 Several other organic solutes (proline, glycine, trimethylamine N-oxide, glycerol, and myo-inositol) that afford cryoprotection to PFK, an effect enhanced by the addition of zinc, do not stabilize the enzyme during air-drying, even if zinc is present. Inositol 87-99 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 131-134 3436952-10 1987 However, this hydrophobicity was lost when acetylcholinesterase was solubilized from bovine erythrocyte membrane by PI-specific phospholipase C. The presence of myo-inositol was confirmed in the purified preparation of acetylcholinesterase by gas chromatography (GC)-mass spectrometry (MS). Inositol 161-173 acetylcholinesterase Bos taurus 43-63 3436952-10 1987 However, this hydrophobicity was lost when acetylcholinesterase was solubilized from bovine erythrocyte membrane by PI-specific phospholipase C. The presence of myo-inositol was confirmed in the purified preparation of acetylcholinesterase by gas chromatography (GC)-mass spectrometry (MS). Inositol 161-173 acetylcholinesterase Bos taurus 219-239 3498982-5 1987 To elucidate why inositol is needed for the mitogen-induced activation of ODC in T lymphocytes, we tested the ability of different inositol metabolites to reverse the inhibitory effect of Li+. Inositol 17-25 ornithine decarboxylase 1 Homo sapiens 74-77 3498982-6 1987 Here we report that inositol phospholipids, in addition to inositol, reverse the Li+-induced inhibition of ODC activation, while all other inositol derivatives tested were ineffective. Inositol 20-28 ornithine decarboxylase 1 Homo sapiens 107-110 3498982-6 1987 Here we report that inositol phospholipids, in addition to inositol, reverse the Li+-induced inhibition of ODC activation, while all other inositol derivatives tested were ineffective. Inositol 59-67 ornithine decarboxylase 1 Homo sapiens 107-110 2822018-2 1987 In membranes prepared from WI-38 human lung fibroblasts, thrombin activated an inositol-lipid-specific PLC that hydrolysed [32P]PIP2 and [32P]phosphatidylinositol 4-monophosphate (PIP) to [32P]IP3 and [32P]inositol 1,4-bisphosphate (IP2) respectively. Inositol 79-87 coagulation factor II, thrombin Homo sapiens 57-65 2822018-2 1987 In membranes prepared from WI-38 human lung fibroblasts, thrombin activated an inositol-lipid-specific PLC that hydrolysed [32P]PIP2 and [32P]phosphatidylinositol 4-monophosphate (PIP) to [32P]IP3 and [32P]inositol 1,4-bisphosphate (IP2) respectively. Inositol 79-87 inhibitor of nuclear factor kappa B kinase regulatory subunit gamma Homo sapiens 129-132 3035101-0 1987 Thyrotropin-releasing hormone reduces myo-inositol content in rat cerebellum pretreated with lithium. Inositol 38-50 thyrotropin releasing hormone Rattus norvegicus 0-29 3035101-1 1987 The effect of thyrotropin-releasing hormone (TRH) and lithium on myo-inositol metabolism has been assessed in rat cerebral cortex, cerebellar cortex, and sciatic nerves. Inositol 65-77 thyrotropin releasing hormone Rattus norvegicus 14-43 3035101-1 1987 The effect of thyrotropin-releasing hormone (TRH) and lithium on myo-inositol metabolism has been assessed in rat cerebral cortex, cerebellar cortex, and sciatic nerves. Inositol 65-77 thyrotropin releasing hormone Rattus norvegicus 45-48 3035101-4 1987 The myo-inositol level of cerebellar cortex reached its nadir (70% of values in untreated control rats) 30 min after addition of TRH and then returned to the control level at 90 min. Inositol 4-16 thyrotropin releasing hormone Rattus norvegicus 129-132 3035101-5 1987 In cerebral cortex, both lithium alone and lithium plus TRH significantly reduced the myo-inositol level. Inositol 86-98 thyrotropin releasing hormone Rattus norvegicus 56-59 3035101-7 1987 These results suggested that the pharmacological dose of TRH activated phosphatidylinositol turnover in rat cerebellar cortex and subsequently reduced the myo-inositol level in the presence of lithium. Inositol 155-167 thyrotropin releasing hormone Rattus norvegicus 57-60 3153472-2 1987 HPLC analysis of [3H]inositol-labeled cells indicated that AVP stimulated a rapid increase in inositol-1,4,5 trisphosphate (IP3), inositol-1,4 bisphosphate, and inositol-4 monophosphate levels. Inositol 21-29 arginine vasopressin Homo sapiens 59-62 2439402-7 1987 Treatment of a third group of diabetic rats with the aldose reductase inhibitor "Statil" prevented or attenuated accumulations of polyol pathway metabolites and prevented depletion of myo-inositol in the sciatic nerve. Inositol 184-196 aldo-keto reductase family 1 member B1 Rattus norvegicus 53-69 3574774-0 1987 Vasoactive intestinal polypeptide and carbachol act synergistically to induce the hydrolysis of inositol containing phospholipids in the rat superior cervical ganglion. Inositol 96-104 vasoactive intestinal peptide Rattus norvegicus 0-33 3027558-3 1987 Aldose reductase inhibitors firmly link defects in myo-inositol metabolism to activation of the polyol pathway in diabetes; the resulting "sorbitol-myo-inositol hypothesis" has been extended from its application to the lenses and peripheral nerves to most of the tissues involved with diabetic complications. Inositol 51-63 aldo-keto reductase family 1 member B Homo sapiens 0-16 3027558-3 1987 Aldose reductase inhibitors firmly link defects in myo-inositol metabolism to activation of the polyol pathway in diabetes; the resulting "sorbitol-myo-inositol hypothesis" has been extended from its application to the lenses and peripheral nerves to most of the tissues involved with diabetic complications. Inositol 148-160 aldo-keto reductase family 1 member B Homo sapiens 0-16 3561697-2 1987 [8-Arginine] vasopressin activates inositol lipid breakdown in this system in a time- and dose-dependent manner; vasopressin (3 X 10(-7) M) resulted in a 1.8-fold stimulation of inositol phosphate accumulation over control accumulation after 10 min. Inositol 35-43 arginine vasopressin Rattus norvegicus 13-24 3561697-2 1987 [8-Arginine] vasopressin activates inositol lipid breakdown in this system in a time- and dose-dependent manner; vasopressin (3 X 10(-7) M) resulted in a 1.8-fold stimulation of inositol phosphate accumulation over control accumulation after 10 min. Inositol 35-43 arginine vasopressin Rattus norvegicus 113-124 3030297-3 1987 We have utilized A-431 cells to examine the influence of EGF on formation of an intracellular second messenger, inositol, 1,4,5-trisphosphate (Ins-1,4,5-P3), and other inositol phosphates. Inositol 112-120 epidermal growth factor Homo sapiens 57-60 3567985-1 1987 The crystal structure of L-chiro-inositol is monoclinic, P21, with a = 6.867(3), b = 9.133(4), c = 6.217(3) A, beta = 106.59(4) degrees, Z = 2. Inositol 25-41 H3 histone pseudogene 16 Homo sapiens 57-60 2948571-10 1987 Several other organic solutes (proline, 4-hydroxyproline, glycine, trimethylamine N-oxide, glycerol and myo-inositol) that afford cryoprotection to phosphofructokinase, an effect enhanced by the addition of zinc, do not stabilize the enzyme during freeze-drying, even if zinc is present. Inositol 104-116 ATP-dependent 6-phosphofructokinase, muscle type Oryctolagus cuniculus 148-167 3593210-0 1987 Removal of covalently bound inositol from Torpedo acetylcholinesterase and mammalian alkaline phosphatases by deamination with nitrous acid. Inositol 28-36 acetylcholinesterase (Cartwright blood group) Homo sapiens 50-70 2823565-2 1987 It is composed of PGE, myoinositol, and one phosphate and has been named cyclic PIP. Inositol 23-34 prolactin induced protein Homo sapiens 80-83 3771575-1 1986 Bradykinin stimulation of inositol polyphosphate production was followed using [3H]inositol-labeled porcine aortic endothelial cells grown in culture. Inositol 26-34 kininogen 1 Homo sapiens 0-10 3827839-0 1986 Stimulation, by vasopressin and other agonists, of inositol-lipid breakdown and inositol phosphate accumulation in WRK 1 cells. Inositol 51-59 arginine vasopressin Homo sapiens 16-27 3490852-0 1986 V1a vasopressin-induced accumulation of inositol trisphosphate in cultured rat aortic myocytes; modulation by protein kinase C. Arginine vasopressin stimulated the accumulation of labeled inositol phosphate in cultured rat aortic myocytes prelabeled with tritiated myo-inositol. Inositol 265-277 arginine vasopressin receptor 1A Rattus norvegicus 0-3 3490852-0 1986 V1a vasopressin-induced accumulation of inositol trisphosphate in cultured rat aortic myocytes; modulation by protein kinase C. Arginine vasopressin stimulated the accumulation of labeled inositol phosphate in cultured rat aortic myocytes prelabeled with tritiated myo-inositol. Inositol 265-277 arginine vasopressin Rattus norvegicus 4-15 3490852-0 1986 V1a vasopressin-induced accumulation of inositol trisphosphate in cultured rat aortic myocytes; modulation by protein kinase C. Arginine vasopressin stimulated the accumulation of labeled inositol phosphate in cultured rat aortic myocytes prelabeled with tritiated myo-inositol. Inositol 265-277 arginine vasopressin Rattus norvegicus 137-148 3023284-6 1986 VAL2C(YEp CHO1) is a plasmid-bearing strain that over produces phosphatidylserine synthase activity, and the opi1 mutant is an inositol biosynthesis regulatory mutant. Inositol 127-135 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 109-113 3021189-4 1986 Formation of inositol phosphates (IP) was measured in [3H]-inositol labelled platelets after incubation with collagen and thrombin for 30 min, a time at which a maximal increase in [3H]-IP was observed. Inositol 13-21 coagulation factor II, thrombin Homo sapiens 122-130 3025587-1 1986 The INO1 gene of Saccharomyces cerevisiae encodes the regulated enzyme inositol-1-phosphate synthase, which catalyzes the first committed step in the synthesis of inositol-containing phospholipids. Inositol 71-79 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 3025587-6 1986 The level of INO1 RNA was repressed 12-fold when the cells were grown in medium containing inositol, and it was repressed 33-fold when the cells were grown in the presence of inositol and choline together. Inositol 91-99 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 13-17 3025587-6 1986 The level of INO1 RNA was repressed 12-fold when the cells were grown in medium containing inositol, and it was repressed 33-fold when the cells were grown in the presence of inositol and choline together. Inositol 175-183 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 13-17 3025587-7 1986 The INO1 transcript was present at a very low level in cells containing mutations (ino2 and ino4) in regulatory genes unlinked to INO1 that result in inositol auxotrophy. Inositol 150-158 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 4-8 3025587-7 1986 The INO1 transcript was present at a very low level in cells containing mutations (ino2 and ino4) in regulatory genes unlinked to INO1 that result in inositol auxotrophy. Inositol 150-158 Ino2p Saccharomyces cerevisiae S288C 83-87 3025587-7 1986 The INO1 transcript was present at a very low level in cells containing mutations (ino2 and ino4) in regulatory genes unlinked to INO1 that result in inositol auxotrophy. Inositol 150-158 Ino4p Saccharomyces cerevisiae S288C 92-96 3025587-7 1986 The INO1 transcript was present at a very low level in cells containing mutations (ino2 and ino4) in regulatory genes unlinked to INO1 that result in inositol auxotrophy. Inositol 150-158 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 130-134 3025587-8 1986 The transcript was constitutively overproduced in cells containing a mutation (opi1) that causes constitutive expression of inositol-1-phosphate synthase and results in excretion of inositol. Inositol 124-132 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 79-83 3025587-11 1986 Inositol and choline together were required for repression of the INO1 transcript in these cells, providing evidence for a regulatory link between the synthesis of inositol- and choline-containing lipids. Inositol 0-8 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 66-70 3025587-11 1986 Inositol and choline together were required for repression of the INO1 transcript in these cells, providing evidence for a regulatory link between the synthesis of inositol- and choline-containing lipids. Inositol 164-172 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 66-70 3091591-2 1986 fMet-Leu-Phe (fMLP) stimulated the formation of inositol bis- and trisphosphate in the [3H]inositol-labeled plasma membranes from the human leukemic (HL-60) cells differentiated to neutrophil-like cells by dibutyryl cyclic AMP. Inositol 48-56 formyl peptide receptor 1 Homo sapiens 14-18 3091591-4 1986 The fMLP-stimulated formation of the phosphorylated inositols was markedly reduced by the prior ADP-ribosylation of the membranes with pertussis toxin. Inositol 52-61 formyl peptide receptor 1 Homo sapiens 4-8 3091591-6 1986 Reconstitution of the membranes ADP-ribosylated by pertussis toxin with Gi or Go purified from rat brain restored the fMLP-stimulated formation of the phosphorylated inositols. Inositol 166-175 formyl peptide receptor 1 Homo sapiens 118-122 3026353-9 1986 In the absence of Li+, radioactivity in vasopressin-stimulated hepatocytes accumulated almost entirely in free inositol. Inositol 111-119 arginine vasopressin Homo sapiens 40-51 3016898-8 1986 Hydrolysis of the glycolipid precursor and subsequent generation of products could be reproduced by incubation of extracted lipids with a phosphatidylinositol-specific phospholipase C. These studies suggest that insulin stimulates an endogenous, selective phospholipase C activity that hydrolyzes a novel glycolipid, resulting in the generation of a complex carbohydrate-phosphate substance containing inositol and glucosamine that may mediate some of the actions of the hormone. Inositol 150-158 insulin Homo sapiens 212-219 3013648-0 1986 myo-Inositol reverses Li+-induced inhibition of phosphoinositide turnover and ornithine decarboxylase induction during early lymphocyte activation. Inositol 0-12 ornithine decarboxylase 1 Homo sapiens 78-101 3013648-9 1986 Here we report that when human blood lymphocytes are kept in an inositol-deficient medium for 30 min in the presence of 1 mM Li+, the cells become unable to respond to mitogens by inositide breakdown and rapid induction of ODC activity. Inositol 64-72 ornithine decarboxylase 1 Homo sapiens 223-226 3525488-2 1986 Effect of inositol supplementation and time from parturition on serum insulin, thyroxine and triiodothyronine and their relationship to serum and liver lipids in dairy cows. Inositol 10-18 insulin Bos taurus 70-77 2870921-2 1986 When (methyl-2H3)methylmalonyl-CoA was reacted with partially purified methylmalonyl-CoA mutase, 1H-NMR revealed that about 24% of the migrating deuterium was lost after 88% conversion. Inositol 13-16 methylmalonyl-CoA mutase Homo sapiens 71-95 3090472-2 1986 When [3H]inositol-prelabelled rat anterior hemipituitaries were incubated with AII (10 microM) for 30 min in the presence of Li+ (10 mM), the production of IP, IP2 and IP3 were increased to 182, 199 and 158% of paired control values. Inositol 9-17 angiotensinogen Rattus norvegicus 79-82 3006784-2 1986 Since the aldose reductase inhibitor, Sorbinil, prevents the fall in myo-inositol and the decrease in (Na+ + K+)-ATPase activity associated with diabetes, phospholipid and phosphatidylinositol content were also examined in glomeruli isolated from Sorbinil-treated diabetic rats. Inositol 69-81 aldo-keto reductase family 1 member B1 Rattus norvegicus 10-26 3741381-6 1986 Vasopressin increased the cellular content of labelled inositol mono-, bis- and tris-phosphate in cells prelabelled with myo-[3H]inositol. Inositol 55-63 arginine vasopressin Rattus norvegicus 0-11 3503534-2 1986 We examined whether parathyroid hormone (PTH) and calcitonin (CT), two hormones that affect bone physiology, would elicit changes in inositol-phospholipid metabolism in cultured bone. Inositol 133-141 parathyroid hormone Rattus norvegicus 20-39 3503534-2 1986 We examined whether parathyroid hormone (PTH) and calcitonin (CT), two hormones that affect bone physiology, would elicit changes in inositol-phospholipid metabolism in cultured bone. Inositol 133-141 parathyroid hormone Rattus norvegicus 41-44 3503534-2 1986 We examined whether parathyroid hormone (PTH) and calcitonin (CT), two hormones that affect bone physiology, would elicit changes in inositol-phospholipid metabolism in cultured bone. Inositol 133-141 calcitonin-related polypeptide alpha Rattus norvegicus 50-60 3503534-2 1986 We examined whether parathyroid hormone (PTH) and calcitonin (CT), two hormones that affect bone physiology, would elicit changes in inositol-phospholipid metabolism in cultured bone. Inositol 133-141 calcitonin-related polypeptide alpha Rattus norvegicus 62-64 3503534-4 1986 PTH enhanced the incorporation of inositol into PtdIns in limb bones following 2- or 24-h hormone treatments. Inositol 34-42 parathyroid hormone Rattus norvegicus 0-3 3503534-6 1986 In contrast, 24-h treatment with CT-inhibited inositol incorporation, also in a dose-dependent manner. Inositol 46-54 calcitonin-related polypeptide alpha Rattus norvegicus 33-35 3007742-1 1986 Both muscarine and vasopressin have been shown previously to increase the accumulation [3H]inositol phosphates in superior cervical ganglia in which the phospholipids were labeled with [3H] inositol. Inositol 91-99 arginine vasopressin Rattus norvegicus 19-30 2869037-2 1986 Bovine aortic and cerebral microvascular endothelial cells and cultured segments of canine common carotid artery possess functional receptors for the nonapeptide bradykinin which mediate a rapid increase in the formation of [3H]inositol 1-phosphate, [3H]inositol 1,4-bisphosphate, and [3H]inositol 1,4,5-trisphosphate from cell membranes containing isotopically labeled myo-inositol. Inositol 370-382 kininogen 1 Canis lupus familiaris 162-172 3005271-3 1986 In the present study, thyrotropin-releasing hormone (TRH) stimulation of polyphosphoinositide turnover has been characterized in electrically permeabilized, [3H]myoinositol-labeled GH3 cells. Inositol 161-172 thyrotropin releasing hormone Rattus norvegicus 22-51 3005271-3 1986 In the present study, thyrotropin-releasing hormone (TRH) stimulation of polyphosphoinositide turnover has been characterized in electrically permeabilized, [3H]myoinositol-labeled GH3 cells. Inositol 161-172 thyrotropin releasing hormone Rattus norvegicus 53-56 3001231-1 1986 The hippocampal vasopressin receptors have been characterised by measuring the stimulated accumulation of inositol monophosphate in the presence of 10 mM LiCl after hippocampal slices were prelabelled with [3H]inositol. Inositol 106-114 arginine vasopressin Rattus norvegicus 16-27 2431858-5 1986 When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Inositol 18-30 aldo-keto reductase family 1 member B1 Rattus norvegicus 102-118 2431858-5 1986 When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Inositol 18-30 choline O-acetyltransferase Rattus norvegicus 169-194 2431858-5 1986 When the level of myo-inositol was maintained, either by feeding myo-inositol or by the inhibition of aldose reductase, the development of defective axonal transport of choline acetyltransferase and choline-containing lipids was prevented. Inositol 65-77 choline O-acetyltransferase Rattus norvegicus 169-194 3024950-4 1986 Aldose reductase inhibitors have been shown to restore to normal both the myo-inositol content and the sodium-potassium ATPase activity of nerve. Inositol 74-86 aldo-keto reductase family 1 member B Homo sapiens 0-16 3024950-5 1986 This suggests that the acute effects of aldose-reductase inhibitors on nerve conduction in both diabetic animals and human patients may be modified by the correction of an underlying myo-inositol-related defect of nerve sodium-potassium ATPase. Inositol 183-195 aldo-keto reductase family 1 member B Homo sapiens 40-56 3792231-4 1986 Abnormalities of sorbitol and myo-inositol metabolism have been described in animal models and human studies of neuropathy and must be regarded as of major importance, especially since they can be profoundly influenced by blocking the enzyme aldose reductase. Inositol 30-42 aldo-keto reductase family 1 member B Homo sapiens 242-258 3000175-4 1985 Aldose reductase inhibitors have been shown to normalize both nerve myo-inositol content and nerve sodium-potassium adenosinetriphosphatase activity. Inositol 68-80 aldo-keto reductase family 1 member B Homo sapiens 0-16 3000175-5 1985 These observations suggest that the acute effects of aldose reductase inhibitors on nerve conduction in both animals and humans with diabetes may be mediated by correction of an underlying myo-inositol-related nerve sodium-potassium adenosinetriphosphatase defect. Inositol 189-201 aldo-keto reductase family 1 member B Homo sapiens 53-69 2995180-4 1985 Administration of the aldose reductase inhibitor, sorbinil, which normalizes glomerular contents of both sorbitol and myo-inositol in diabetes, completely prevented the diminution of Na/K-ATPase activity. Inositol 118-130 aldo-keto reductase family 1 member B1 Rattus norvegicus 22-38 2410289-1 1985 This study examined the effects of myo-inositol treatment on the deficits of motor nerve conduction velocity and of axonal transport of choline acetyltransferase in rats with streptozotocin-induced diabetes. Inositol 35-47 choline O-acetyltransferase Rattus norvegicus 136-161 3928685-4 1985 Myo-inositol administration or treatment with sorbinil, an inhibitor of aldose reductase, arrested the decline in the c-wave. Inositol 0-12 aldo-keto reductase family 1 member B1 Rattus norvegicus 72-88 3888957-1 1985 Phospholipid metabolism in the Saccharomyces cerevisiae opi1 mutant, which excretes inositol and is constitutive for the biosynthetic enzyme inositol-1-phosphate synthase (M. Greenberg, P. Goldwasser, and S. Henry, Mol. Inositol 84-92 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 56-60 4004881-0 1985 Identification of covalently bound inositol in the hydrophobic membrane-anchoring domain of Torpedo acetylcholinesterase. Inositol 35-43 acetylcholinesterase (Cartwright blood group) Homo sapiens 100-120 4004881-4 1985 Here we demonstrate the presence of covalently bound inositol in the membrane-anchoring domain of purified Torpedo acetylcholinesterase. Inositol 53-61 acetylcholinesterase (Cartwright blood group) Homo sapiens 115-135 2579070-3 1985 In pancreas microsomes, in the presence of saturating myo-inositol, the alpha, beta, gamma, and delta isomers (4 mM) inhibited PI synthase activity by 9, 4, 22, and 69%, respectively. Inositol 54-66 CDP-diacylglycerol--inositol 3-phosphatidyltransferase (phosphatidylinositol synthase) Mus musculus 127-138 6091780-0 1984 Changes in [3H]inositol-labelled phosphoinositides of pig platelets in response to thrombin. Inositol 15-23 coagulation factor II, thrombin Sus scrofa 83-91 6439191-6 1984 Addition of TRH to cells suspended in lithium-containing medium depleted cellular inositol levels by around 65% within 30 min. Inositol 82-90 thyrotropin releasing hormone Rattus norvegicus 12-15 6392853-4 1984 The ino2 and ino4 mutants, originally isolated on the basis of an inositol requirement, are unable to derepress the cytoplasmic enzyme inositol-1-phosphate synthase (myo-inositol-1-phosphate synthase; EC 5.5.1.4). Inositol 66-74 Ino2p Saccharomyces cerevisiae S288C 4-8 6392853-4 1984 The ino2 and ino4 mutants, originally isolated on the basis of an inositol requirement, are unable to derepress the cytoplasmic enzyme inositol-1-phosphate synthase (myo-inositol-1-phosphate synthase; EC 5.5.1.4). Inositol 66-74 Ino4p Saccharomyces cerevisiae S288C 13-17 6392853-9 1984 The pleiotropic phenotype of the ino2 and ino4 mutants described in this paper suggests that the INO2 and INO4 loci are involved in the regulation of phospholipid methylation in the membrane as well as inositol biosynthesis in the cytoplasm. Inositol 202-210 Ino2p Saccharomyces cerevisiae S288C 33-37 6392853-9 1984 The pleiotropic phenotype of the ino2 and ino4 mutants described in this paper suggests that the INO2 and INO4 loci are involved in the regulation of phospholipid methylation in the membrane as well as inositol biosynthesis in the cytoplasm. Inositol 202-210 Ino4p Saccharomyces cerevisiae S288C 42-46 6392853-9 1984 The pleiotropic phenotype of the ino2 and ino4 mutants described in this paper suggests that the INO2 and INO4 loci are involved in the regulation of phospholipid methylation in the membrane as well as inositol biosynthesis in the cytoplasm. Inositol 202-210 Ino2p Saccharomyces cerevisiae S288C 97-101 6392853-9 1984 The pleiotropic phenotype of the ino2 and ino4 mutants described in this paper suggests that the INO2 and INO4 loci are involved in the regulation of phospholipid methylation in the membrane as well as inositol biosynthesis in the cytoplasm. Inositol 202-210 Ino4p Saccharomyces cerevisiae S288C 106-110 6384202-1 1984 Secretion of acid phosphatase and invertase was examined in an inositol-requiring ino1 mutant of the yeast Saccharomyces cerevisiae. Inositol 63-71 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 82-86 6497780-0 1984 The contribution of inositol exchange to agonist-stimulated breakdown of myo- [2-3H] inositol-labelled phosphatidylinositol in mouse exocrine pancreas. Inositol 20-28 synaptopodin 2 Mus musculus 73-76 6237272-1 1984 The studies, performed on 40 patients with brachialgia and ischialgia syndromes, showed higher CSF inositol concentrations in comparison with healthy subjects. Inositol 99-107 colony stimulating factor 2 Homo sapiens 95-98 6321943-0 1984 Thyrotropin-releasing hormone-stimulated [3H]inositol metabolism in GH3 pituitary tumor cells. Inositol 45-53 thyrotropin releasing hormone Rattus norvegicus 0-29 6321943-4 1984 Separation of the [3H]inositol metabolites by ion-exchange chromatography revealed that TRH induced a rapid rise in the cellular content of [3H]inositol mono-, bis-, and trisphosphate. Inositol 22-30 thyrotropin releasing hormone Rattus norvegicus 88-91 6365588-2 1984 It was shown that the decrease in phosphatidylinositol (PI) content in cdc 28 G1-cells was due to a defect in inositol transport. Inositol 46-54 cyclin-dependent serine/threonine-protein kinase CDC28 Saccharomyces cerevisiae S288C 71-77 6311628-4 1983 The change in this ratio also provided evidence for the existence of CDP-DG + inositol in equilibrium phosphatidylinositol exchange reaction in the intact tissue. Inositol 78-86 cut-like homeobox 1 Rattus norvegicus 69-72 6412762-0 1983 Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II. Inositol 0-8 arginine vasopressin Rattus norvegicus 127-138 6412762-0 1983 Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II. Inositol 0-8 angiotensinogen Rattus norvegicus 143-157 6622816-4 1983 31, 2745-2753 (1982) we established the formation of reactive metabolic intermediates (MI) during metabolism of orphenadrine and its mono-N-demethylated metabolite tofenacine, which may block cytochrome P-450 (MI-complex). Inositol 87-89 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 192-208 6622816-4 1983 31, 2745-2753 (1982) we established the formation of reactive metabolic intermediates (MI) during metabolism of orphenadrine and its mono-N-demethylated metabolite tofenacine, which may block cytochrome P-450 (MI-complex). Inositol 210-212 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 192-208 6622816-6 1983 Three different assays were used to establish the amount of cytochrome P-450 involved in MI-complexation, which was induced by tofenacine (30 mg/kg i.p.) Inositol 89-91 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 60-76 6622816-9 1983 Our data also suggest that MI-complexation is generated on phenobarbital induced cytochrome P-450 species. Inositol 27-29 cytochrome P450, family 2, subfamily g, polypeptide 1 Rattus norvegicus 81-97 6847682-1 1983 Greatly enhanced manganese-dependent phosphatidylinositol:myo-inositol exchange activity was observed when isolated, intact nerve-endings were incubated with the nucleotide, CMP, suggesting that the enzyme, CDP-diglyceride:inositol phosphatidyl transferase, catalyzes this exchange. Inositol 58-70 cut like homeobox 1 Homo sapiens 207-210 6304096-0 1983 Quantitation and early kinetics of inositol lipid changes induced by vasopressin in isolated and cultured hepatocytes. Inositol 35-43 arginine vasopressin Homo sapiens 69-80 6403536-3 1983 The calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalene sulfonamide hydrochloride (W-7) (10-100 microM) abolished or suppressed Ca++-stimulated immunoreactive prostaglandin E, labeled arachidonate and prostaglandin release, and the fall in labeled phospholipids but did not suppress labeled diglyceride or inositol accumulation. Inositol 316-324 calmodulin 1 Rattus norvegicus 4-14 6870806-7 1983 Inclusion of an aldose reductase inhibitor in the medium counteracted the reduced myo-inositol transport caused by elevated glucose concentration. Inositol 82-94 aldo-keto reductase family 1 member B1 Rattus norvegicus 16-32 6337138-5 1983 These data suggest that insulin antagonism of alpha-adrenergic effects on glycogenolysis in liver is mediated at a step distal to hormone binding to the alpha 1-receptor and activation of inositol lipid breakdown but prior to intracellular Ca2+ mobilization. Inositol 188-196 insulin Homo sapiens 24-31 6818625-2 1982 The permeability constant (Kin) of inositol averaged 0.27 +/- 0.02 ml X (100 g)-1 X min-1 or 4 X 10(-7) cm X s-1 at a cerebral capillary surface area of 100 cm2 x g-1. Inositol 35-43 Kin17 DNA and RNA binding protein Rattus norvegicus 27-30 7092859-0 1982 Nerve growth factor rescues clonal PC-12 pheochromocytoma cells from "inositol-less death". Inositol 70-78 nerve growth factor Rattus norvegicus 0-19 7047296-4 1982 Genetic analysis of the mutants indicates that at least three loci (designated OPI1, OPI2 and OPI4) direct inositol-mediated repression of I-1-P synthase. Inositol 107-115 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 79-83 6809505-2 1982 myo-Inositol was galactosylated by UDP-galactose in the presence of alpha-lactalbumin plus rat mammary Golgi membranes enriched in galactosyltransferase (EC 2.4.1.22). Inositol 0-12 lactalbumin, alpha Rattus norvegicus 68-85 6809505-2 1982 myo-Inositol was galactosylated by UDP-galactose in the presence of alpha-lactalbumin plus rat mammary Golgi membranes enriched in galactosyltransferase (EC 2.4.1.22). Inositol 0-12 glycoprotein alpha-galactosyltransferase 1 Rattus norvegicus 131-152 7298620-4 1981 These peak positions were in good agreement with those reported for imidazole methemoglobin upon addition of inositol of hexaphosphate (IHP). Inositol 109-117 hemoglobin subunit gamma 2 Homo sapiens 78-91 17249096-0 1981 Inositol Mutants of SACCHAROMYCES CEREVISIAE: Mapping the ino1 Locus and Characterizing Alleles of the ino1, ino2 and ino4 Loci. Inositol 0-8 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 58-62 17249096-0 1981 Inositol Mutants of SACCHAROMYCES CEREVISIAE: Mapping the ino1 Locus and Characterizing Alleles of the ino1, ino2 and ino4 Loci. Inositol 0-8 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 103-107 17249096-0 1981 Inositol Mutants of SACCHAROMYCES CEREVISIAE: Mapping the ino1 Locus and Characterizing Alleles of the ino1, ino2 and ino4 Loci. Inositol 0-8 Ino2p Saccharomyces cerevisiae S288C 109-113 17249096-0 1981 Inositol Mutants of SACCHAROMYCES CEREVISIAE: Mapping the ino1 Locus and Characterizing Alleles of the ino1, ino2 and ino4 Loci. Inositol 0-8 Ino4p Saccharomyces cerevisiae S288C 118-122 17249096-3 1981 Approximately 70% of all inositol auxotrophs isolated are shown to be alleles of the ino1 locus, the structural gene for inositol-1-phosphate synthase, the major enzyme involved in inositol biosynthesis. Inositol 25-33 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 85-89 17249096-3 1981 Approximately 70% of all inositol auxotrophs isolated are shown to be alleles of the ino1 locus, the structural gene for inositol-1-phosphate synthase, the major enzyme involved in inositol biosynthesis. Inositol 121-129 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 85-89 7287687-1 1981 The preferential solvent interaction with bovine serum albumin in aqueous solution of polyhydric alcohols (ethylene glycol, glycerol, xylitol, sorbitol, mannitol, and inositol) was investigated by a densimetric method with the application of multicomponent theory. Inositol 167-175 albumin Homo sapiens 49-62 224862-4 1979 Inositol oxygenase (EC 1.13.99.1), which converts myo-inositol into glucuronic acid, was also less active in kidney from diabetic animals. Inositol 50-62 myo-inositol oxygenase Rattus norvegicus 0-18 221533-0 1979 Effects of glucose and parathyroid hormone on the renal handling of myoinositol by isolated perfused dog kidneys. Inositol 68-79 parathyroid hormone Canis lupus familiaris 23-42 221533-1 1979 The effects of glucose and parathyroid hormone (PTH) on the transport and metabolism of myoinositol (MI) and [2-(3)H]MI were studied in isolated perfused dog kidneys. Inositol 88-99 parathyroid hormone Canis lupus familiaris 27-46 221533-1 1979 The effects of glucose and parathyroid hormone (PTH) on the transport and metabolism of myoinositol (MI) and [2-(3)H]MI were studied in isolated perfused dog kidneys. Inositol 88-99 parathyroid hormone Canis lupus familiaris 48-51 437700-2 1979 Using the technique of affinity chromatography on a myo-inositol-substituted Sepharose, the myo-inositol oxygenase from rat kidneys was purified to homogeneity. Inositol 52-64 myo-inositol oxygenase Rattus norvegicus 96-114 210818-2 1978 Its inhibition with myo-inositol (Ki = 0.29 M) was similar to that observed with alpha-galactosidase A from various tissues. Inositol 20-32 galactosidase alpha Homo sapiens 81-102 18462-9 1977 The Km for myo-inositol was 2.5 X 10(-3) M and that for CDP-diglyceride was 1.7 X 10(-4) M. The pH optimum was 8.6. Inositol 11-23 cut-like homeobox 1 Rattus norvegicus 56-59 18992-0 1977 Solubilization of the enzyme catalyzing CDP-diglyceride-independent incorporation of myo-inositol into phosphatidyl inositol and its comparison to CDP-diglyceride:inositol transferase. Inositol 85-97 cut like homeobox 1 Homo sapiens 40-43 870607-3 1977 Bones from mi mice showed a generalized resorption defect with decreased spontaneous or control resorption and failure to respond to parathyroid hormone (PTH), prostaglandin E2, 1,25 dihydroxy vitamin D3, vitamin A, or osteoclast activating factor (OAF) from human peripheral leukocytes or mouse spleen cells. Inositol 11-13 parathyroid hormone Mus musculus 154-157 870607-3 1977 Bones from mi mice showed a generalized resorption defect with decreased spontaneous or control resorption and failure to respond to parathyroid hormone (PTH), prostaglandin E2, 1,25 dihydroxy vitamin D3, vitamin A, or osteoclast activating factor (OAF) from human peripheral leukocytes or mouse spleen cells. Inositol 11-13 out at first homolog Mus musculus 219-253 838172-4 1977 Insulin treatment restored the urinary myoinositol excretion toward normal. Inositol 39-50 insulin Homo sapiens 0-7 838172-7 1977 This abnormality in oral myoinositol tolerance was also corrected by insulin treatment. Inositol 25-36 insulin Homo sapiens 69-76 838172-8 1977 The size of the rapidly equilibrating myoinositol pool was significantly decreased in the untreated diabetic and returned to normal following a brief period of insulin treatment. Inositol 38-49 insulin Homo sapiens 160-167 1008476-4 1976 The plasma myoinositol level increased more than the CSF and red-cell levels, indicating that the myoinositol in the red cells and the CSF originated mostly in plasma. Inositol 11-22 colony stimulating factor 2 Homo sapiens 135-138 1267771-0 1976 The identification of MYO-inositol:NAD(P)+ oxidoreductase in mammalian brain. Inositol 22-34 thioredoxin reductase 1 Homo sapiens 43-57 945861-4 1976 Among six studied vitamins (B1, B3, B6, PP, B7, B8), the content of inositol was highest (398.2 mcg/g), B3 was not found, and only traces of other vitamins were detected. Inositol 68-76 immunoglobulin kappa variable 7-3 (pseudogene) Homo sapiens 28-50 17808690-0 1959 Enhancement by Inositol of the Nodulation of Isolated Bean Roots. Inositol 15-23 brain expressed associated with NEDD4 1 Homo sapiens 54-58 17808690-1 1959 The percentage of isolated bean roots nodulated and the number of nodules per root were increased by the addition of mesoinositol to the agar medium into which the bases of bean roots were inserted. Inositol 117-129 brain expressed associated with NEDD4 1 Homo sapiens 27-31 17808690-1 1959 The percentage of isolated bean roots nodulated and the number of nodules per root were increased by the addition of mesoinositol to the agar medium into which the bases of bean roots were inserted. Inositol 117-129 brain expressed associated with NEDD4 1 Homo sapiens 173-177 13547872-0 1958 [Paper chromatography of carbohydrates & mesoinositol in CSF]. Inositol 45-57 colony stimulating factor 2 Homo sapiens 61-65 14926441-0 1951 [Results with tocopheryl phosphate and inositol therapy of Erb"s progressive muscular dystrophy]. Inositol 39-47 estrogen receptor 2 Homo sapiens 59-62 18891788-0 1948 Inositol, an active constituent of pancreatic (alpha)amylase. Inositol 0-8 amylase alpha 2A Homo sapiens 35-60 33900381-6 2021 Fatp4M-/- BMDMs showed specificity in attenuating TM-induced activation of inositol-requiring enzyme1alpha, but not other unfolded protein response pathways. Inositol 75-83 solute carrier family 27 (fatty acid transporter), member 4 Mus musculus 0-5 33988478-7 2021 Vitamin E and inositols were successful in increasing SHBG levels; inositols were stronger than vitamin E. Inositol 14-23 sex hormone binding globulin Homo sapiens 54-58 33367686-8 2021 Two processes known to be mediated by INOSITOL REQUIRING ENZYME1 (IRE1)-accumulation of the spliced bZIP60 transcript and a decrease in the transcript levels of PR4 and PRX34, encoding secretory proteins-were observed in sloh4 in response to L-heat stress. Inositol 38-46 basic region/leucine zipper motif 60 Arabidopsis thaliana 100-106 33367686-8 2021 Two processes known to be mediated by INOSITOL REQUIRING ENZYME1 (IRE1)-accumulation of the spliced bZIP60 transcript and a decrease in the transcript levels of PR4 and PRX34, encoding secretory proteins-were observed in sloh4 in response to L-heat stress. Inositol 38-46 pathogenesis-related 4 Arabidopsis thaliana 161-164 33367686-8 2021 Two processes known to be mediated by INOSITOL REQUIRING ENZYME1 (IRE1)-accumulation of the spliced bZIP60 transcript and a decrease in the transcript levels of PR4 and PRX34, encoding secretory proteins-were observed in sloh4 in response to L-heat stress. Inositol 38-46 peroxidase CB Arabidopsis thaliana 169-174 33947921-5 2021 The screening system to track X-box binding protein 1 (XBP1) splicing activity revealed that the ethanol extract of the Periploca calophylla stem inhibited the inositol-requiring enzyme 1 (IRE1)-XBP1 pathway. Inositol 160-168 X-box binding protein 1 Homo sapiens 55-59 33947921-5 2021 The screening system to track X-box binding protein 1 (XBP1) splicing activity revealed that the ethanol extract of the Periploca calophylla stem inhibited the inositol-requiring enzyme 1 (IRE1)-XBP1 pathway. Inositol 160-168 X-box binding protein 1 Homo sapiens 195-199 33205567-3 2021 A 26-nt-long ncRNA (X26nt) is generated in the process of inositol requiring-enzyme 1 alpha (IRE1alpha) induced unspliced XBP1 splicing. Inositol 58-66 RNANC Homo sapiens 13-18 33205567-3 2021 A 26-nt-long ncRNA (X26nt) is generated in the process of inositol requiring-enzyme 1 alpha (IRE1alpha) induced unspliced XBP1 splicing. Inositol 58-66 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 93-102 33205567-3 2021 A 26-nt-long ncRNA (X26nt) is generated in the process of inositol requiring-enzyme 1 alpha (IRE1alpha) induced unspliced XBP1 splicing. Inositol 58-66 X-box binding protein 1 Homo sapiens 122-126 33721623-18 2021 The mean (range) dose of insulin was 25.3 units in myoinositol group compared to 14.27 units in controls (p = 0.058). Inositol 51-62 insulin Homo sapiens 25-32 33983135-8 2021 Knock-down of Sdhb and Vhl in an in vitro model demonstrated that inositol metabolism and sialic acids were similarly modulated as in tumors of the respective cluster. Inositol 66-74 succinate dehydrogenase complex iron sulfur subunit B Rattus norvegicus 14-18 33983135-8 2021 Knock-down of Sdhb and Vhl in an in vitro model demonstrated that inositol metabolism and sialic acids were similarly modulated as in tumors of the respective cluster. Inositol 66-74 von Hippel-Lindau tumor suppressor Rattus norvegicus 23-26 33421129-8 2021 The cerebellum showed only a significant increase in myo-inositol between p35-p77. Inositol 53-65 cyclin-dependent kinase 5 regulatory subunit 1 Rattus norvegicus 74-77 33931115-3 2021 RESULTS: The opi1 gene was knocked out because of its negative regulation on myo-inositol synthesis, which is the limiting step of D-glucaric acid production by S. cerevisiae. Inositol 77-89 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 13-17 34027646-5 2021 Here, we identify a new role of inositol-requiring transmembrane kinase/endoribonuclease 1alpha (IRE1alpha) in the regulation of plasma lipids. Inositol 32-40 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 97-106 33893377-1 2021 To verify whether myo-inositol plus alpha-lactalbumin may reduce insulin resistance and excessive fetal growth in women with gestational diabetes mellitus. Inositol 18-30 insulin Homo sapiens 65-72 33893377-8 2021 A combination of myo-inositol and alpha-lactalbumin may reduce insulin resistance and excessive fetal growth.Clinical trial registration: ClinicalTrials.gov, http://www.clinicaltrials.gov , NCT03763669, first posted date 04/12/2018; last posted date December 06/12/2018. Inositol 17-29 insulin Homo sapiens 63-70 33846320-2 2021 Here, we identify a BMI1-dependent sensitivity to deregulation of inositol metabolism in a proportion of medulloblastoma. Inositol 66-74 BMI1 proto-oncogene, polycomb ring finger Homo sapiens 20-24 33840122-2 2021 The response is mediated by a conserved signaling network composed of two branches - one branch involving INOSITOL REQUIRING ENZYME1- BASIC LEUCINE ZIPPER60 (IRE1-bZIP60) signaling pathway and another branch involving the membrane transcription factors, bZIP17 and - 28. Inositol 106-114 uncharacterized protein Chlamydomonas reinhardtii 158-162 33916518-9 2021 JNK activation was induced by stress response-associated inositol-requiring enzyme-1alpha (IRE1alpha) in response to Crenolanib treatment, whereas beta-catenin-dependent WNT signaling was able to counteract this process. Inositol 57-65 mitogen-activated protein kinase 8 Rattus norvegicus 0-3 33063293-10 2021 SCA1 revealed a decrease of aspartate (Asp) in the vermis (62%) and an elevation in the prefrontal cortex (130%) as well as an elevation of myo-inositol (Ins) in the cerebellar hemisphere (51%) and pons (46%). Inositol 140-152 ataxin 1 Homo sapiens 0-4 33063293-10 2021 SCA1 revealed a decrease of aspartate (Asp) in the vermis (62%) and an elevation in the prefrontal cortex (130%) as well as an elevation of myo-inositol (Ins) in the cerebellar hemisphere (51%) and pons (46%). Inositol 154-157 ataxin 1 Homo sapiens 0-4 33928619-2 2021 Alpha-lactalbumin was used being effective in increasing myo-inositol intestinal absorption. Inositol 57-69 lactalbumin alpha Homo sapiens 0-17 32945218-11 2021 CONCLUSIONS: Myoinositol (4 g) might be used alone as an insulin sensitizer to improve metabolic, hormonal and reproductive outcome in infertile PCOS women. Inositol 13-24 insulin Homo sapiens 57-64 33561013-2 2021 The endoplasmic reticulum stress sensor inositol-requiring enzyme 1 alpha (IRE1alpha) has been implicated as a perpetuator of inflammation in various chronic diseases; however, IRE1alpha has been little studied in relation to neutrophil function or lupus pathogenesis. Inositol 40-48 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 75-84 33561013-2 2021 The endoplasmic reticulum stress sensor inositol-requiring enzyme 1 alpha (IRE1alpha) has been implicated as a perpetuator of inflammation in various chronic diseases; however, IRE1alpha has been little studied in relation to neutrophil function or lupus pathogenesis. Inositol 40-48 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 177-186 33493945-10 2021 Myo-inositol down-regulates the expression of IL-6 by phosphatidyl-inositol-3-kinase (PI3K) pathway. Inositol 0-12 interleukin 6 Homo sapiens 46-50 33493945-10 2021 Myo-inositol down-regulates the expression of IL-6 by phosphatidyl-inositol-3-kinase (PI3K) pathway. Inositol 0-12 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 54-84 31578497-4 2021 The UPR is a highly orchestrated and complex cellular response, which is mediated through the ER chaperone protein, BiP, three known ER transmembrane stress sensors, protein kinase RNA-like ER kinase (PERK), activating transcription factor-6 (ATF6), inositol requiring enzyme 1alpha (IRE1alpha), and their downstream effectors. Inositol 250-258 growth differentiation factor 10 Homo sapiens 116-119 33743322-0 2021 Dietary supplementation with myo-inositol reduces high-fructose diet-induced hepatic ChREBP binding and acetylation of histones H3 and H4 on the Elovl6 gene in rats. Inositol 29-41 MLX interacting protein-like Rattus norvegicus 85-91 33743322-0 2021 Dietary supplementation with myo-inositol reduces high-fructose diet-induced hepatic ChREBP binding and acetylation of histones H3 and H4 on the Elovl6 gene in rats. Inositol 29-41 ELOVL fatty acid elongase 6 Rattus norvegicus 145-151 33743322-4 2021 Since a major lipotrope, myo-inositol (MI), can repress short-term high-fructose-induced fatty liver and the expression of fatty acid synthesis genes, we hypothesized that MI might influence SREBP-1c, ChREBP, and histone acetylation of Elovl6 in fatty liver induced by even short-term high-fructose intake. Inositol 25-37 sterol regulatory element binding transcription factor 1 Rattus norvegicus 191-199 33743322-4 2021 Since a major lipotrope, myo-inositol (MI), can repress short-term high-fructose-induced fatty liver and the expression of fatty acid synthesis genes, we hypothesized that MI might influence SREBP-1c, ChREBP, and histone acetylation of Elovl6 in fatty liver induced by even short-term high-fructose intake. Inositol 25-37 MLX interacting protein-like Rattus norvegicus 201-207 33743322-4 2021 Since a major lipotrope, myo-inositol (MI), can repress short-term high-fructose-induced fatty liver and the expression of fatty acid synthesis genes, we hypothesized that MI might influence SREBP-1c, ChREBP, and histone acetylation of Elovl6 in fatty liver induced by even short-term high-fructose intake. Inositol 25-37 ELOVL fatty acid elongase 6 Rattus norvegicus 236-242 33859622-0 2021 D-Chiro-Inositol Regulates Insulin Signaling in Human Adipocytes. Inositol 0-16 insulin Homo sapiens 27-34 33859622-1 2021 D-Chiro-Inositol (D-Chiro-Ins) is a secondary messenger in the insulin signaling pathway. Inositol 0-16 insulin Homo sapiens 63-70 33730996-1 2021 Inositol requiring enzyme 1 alpha (IRE1alpha) is one of three signaling sensors in the unfolding protein response (UPR) that alleviates endoplasmic reticulum (ER) stress in cells and functions to promote cell survival. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 35-44 33755975-3 2021 Myo-inositol and D-chiro-inositol are normally stored in kidney, brain and liver and are necessary for functions, such as signal transduction, metabolic flux, insulin signaling, regulation of ion-channel permeability, stress response and embryo development. Inositol 0-12 insulin Homo sapiens 159-166 33755975-3 2021 Myo-inositol and D-chiro-inositol are normally stored in kidney, brain and liver and are necessary for functions, such as signal transduction, metabolic flux, insulin signaling, regulation of ion-channel permeability, stress response and embryo development. Inositol 17-33 insulin Homo sapiens 159-166 33879967-7 2021 Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1alpha (IRE1alpha), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1alpha, were significantly enhanced in IECs in DSS-treated Atg5 DeltaIEC mice. Inositol 19-27 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 79-88 33879967-7 2021 Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1alpha (IRE1alpha), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1alpha, were significantly enhanced in IECs in DSS-treated Atg5 DeltaIEC mice. Inositol 19-27 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 186-195 33879967-7 2021 Phosphorylation of inositol-requiring transmembrane kinase/endonuclease1alpha (IRE1alpha), a sensor for endoplasmic reticulum stress, and c-Jun N-terminal kinase, a downstream target of IRE1alpha, were significantly enhanced in IECs in DSS-treated Atg5 DeltaIEC mice. Inositol 19-27 autophagy related 5 Mus musculus 248-252 32915195-1 2021 BCR-ABL1-positive acute lymphoblastic leukemia (ALL) cell survival is dependent on the inositol requiring enzyme 1 alpha (IRE1alpha) branch of the unfolded protein response. Inositol 87-95 c-abl oncogene 1, non-receptor tyrosine kinase Mus musculus 4-8 32915195-1 2021 BCR-ABL1-positive acute lymphoblastic leukemia (ALL) cell survival is dependent on the inositol requiring enzyme 1 alpha (IRE1alpha) branch of the unfolded protein response. Inositol 87-95 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 122-131 32997390-4 2021 The novel inositols (11-17) had effective inhibition profiles against human carbonic anhydrase isoenzymes I and II (hCA I and II) and acetylcholinesterase (AChE). Inositol 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 116-154 32997390-4 2021 The novel inositols (11-17) had effective inhibition profiles against human carbonic anhydrase isoenzymes I and II (hCA I and II) and acetylcholinesterase (AChE). Inositol 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 156-160 32997390-5 2021 The novel inositols 11-17 were found to be effective inhibitors against AChE, hCA I, and hCA II enzymes. Inositol 10-19 acetylcholinesterase (Cartwright blood group) Homo sapiens 72-76 32997390-5 2021 The novel inositols 11-17 were found to be effective inhibitors against AChE, hCA I, and hCA II enzymes. Inositol 10-19 carbonic anhydrase 1 Homo sapiens 78-83 32926479-5 2021 Here, we investigate the contribution of the inositol-requiring protein-1alpha-X-box binding protein-1 (XBP1)-mediated UPR signaling pathway to the pathogenesis of spinal cord injury (SCI). Inositol 45-53 X-box binding protein 1 Mus musculus 104-108 32776539-4 2021 In addition, the inositol-requiring enzyme 1alpha (IRE1alpha)-endoplasmic reticulum (ER)-stress pathway was activated, and the activity of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) was upregulated in rat livers. Inositol 17-25 NADPH oxidase 4 Rattus norvegicus 139-192 32776539-4 2021 In addition, the inositol-requiring enzyme 1alpha (IRE1alpha)-endoplasmic reticulum (ER)-stress pathway was activated, and the activity of nicotinamide adenine dinucleotide phosphate oxidase 4 (NOX4) was upregulated in rat livers. Inositol 17-25 NADPH oxidase 4 Rattus norvegicus 194-198 33269516-0 2021 Letter to "May myo-inositol and D-chiro-inositol (40:1) treatment be a good option on normal-weighted polycystic ovary syndrome patients without insulin resistance?" Inositol 32-48 insulin Homo sapiens 145-152 33518153-6 2021 The displacement of dextrose with myo-inositol generated a significant linear reduction in the FCR that did not reach a plateau at 5% dietary inclusion of myo-inositol. Inositol 34-46 FCR Gallus gallus 95-98 33553394-0 2021 Impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus patients. Inositol 37-45 insulin Homo sapiens 49-56 33553394-2 2021 AIM: To discuss the impact of different stereoisomers of inositol on insulin sensitivity of gestational diabetes mellitus (GDM) patients. Inositol 57-65 insulin Homo sapiens 69-76 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 37-45 insulin Homo sapiens 103-110 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 37-45 insulin Homo sapiens 134-141 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 103-110 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 134-141 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 103-110 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 134-141 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 103-110 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 134-141 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 103-110 33553394-12 2021 CONCLUSION: Treatment with different inositol stereoisomers (inositol MI and inositol DCI) can improve insulin sensitivity and reduce insulin resistance in diabetic patients, and inositol DCI has a better curative effect than inositol MI. Inositol 61-69 insulin Homo sapiens 134-141 33165596-0 2021 Placental Inositol Reduced in Gestational Diabetes as Glucose alters Inositol Transporters and IMPA1 enzyme expression. Inositol 10-18 inositol monophosphatase 1 Homo sapiens 95-100 33165596-1 2021 CONTEXT: Perturbed inositol physiology in insulin resistant conditions has led to proposals of inositol supplementation for gestational diabetes (GDM) prevention, but placental inositol biology is poorly understood. Inositol 19-27 insulin Homo sapiens 42-49 33165596-1 2021 CONTEXT: Perturbed inositol physiology in insulin resistant conditions has led to proposals of inositol supplementation for gestational diabetes (GDM) prevention, but placental inositol biology is poorly understood. Inositol 95-103 insulin Homo sapiens 42-49 33165596-1 2021 CONTEXT: Perturbed inositol physiology in insulin resistant conditions has led to proposals of inositol supplementation for gestational diabetes (GDM) prevention, but placental inositol biology is poorly understood. Inositol 95-103 insulin Homo sapiens 42-49 33468143-2 2021 Myo-inositol (MI) increases insulin sensitivity, decreases hyperandrogenism and improves the menstrual cycle. Inositol 0-12 insulin Homo sapiens 28-35 33526980-8 2021 Preoperative fasting activated inositol-requiring transmembrane kinase/endoribonuclease (IRE)-1alpha and c-Jun N-terminal kinase (JNK) mediated endoplasmic reticulum (ER)-stress, and reduced glucose transporter type 4 (Glut4) expression in the soleus muscle. Inositol 31-39 solute carrier family 2 member 4 Rattus norvegicus 191-217 33526980-8 2021 Preoperative fasting activated inositol-requiring transmembrane kinase/endoribonuclease (IRE)-1alpha and c-Jun N-terminal kinase (JNK) mediated endoplasmic reticulum (ER)-stress, and reduced glucose transporter type 4 (Glut4) expression in the soleus muscle. Inositol 31-39 solute carrier family 2 member 4 Rattus norvegicus 219-224 32161005-11 2021 Age, baseline BCVA and MI index could serve as predictive risk factors of subretinal fibrosis after anti-VEGF treatment in patients with mCNV. Inositol 23-25 vascular endothelial growth factor A Homo sapiens 105-109 33506934-3 2021 On the one hand, under a metabolic perspective, D-chiro-Inositol improves insulin signaling, thus restoring physiological insulin levels in resistant subjects. Inositol 48-64 insulin Homo sapiens 74-81 33506934-3 2021 On the one hand, under a metabolic perspective, D-chiro-Inositol improves insulin signaling, thus restoring physiological insulin levels in resistant subjects. Inositol 48-64 insulin Homo sapiens 122-129 32433604-2 2021 Inositol, an insulin sensitizer, has been trialled for gestational diabetes prevention. Inositol 0-8 insulin Homo sapiens 13-20 33320079-6 2021 It was observed that IolQ bound to the DNA fragments containing each of the two iol promoter regions and that DNA binding was antagonized by myo-inositol. Inositol 141-153 transcriptional regulator DegA Bacillus subtilis 21-25 33320079-9 2021 IolQ functions as a transcriptional repressor regulating the induction of the two iol operons responding to myo-inositol. Inositol 108-120 transcriptional regulator DegA Bacillus subtilis 0-4 33396378-6 2020 In the ER, TNFalpha selectively phosphorylates inositol-requiring enzyme 1 alpha (pIRE1alpha) triggering downstream splicing of the transcription factor X-box binding protein 1 (XBP1s); thus, activating the pIRE1alpha/XBP1s ER stress pathway. Inositol 47-55 tumor necrosis factor Homo sapiens 11-19 33396378-6 2020 In the ER, TNFalpha selectively phosphorylates inositol-requiring enzyme 1 alpha (pIRE1alpha) triggering downstream splicing of the transcription factor X-box binding protein 1 (XBP1s); thus, activating the pIRE1alpha/XBP1s ER stress pathway. Inositol 47-55 X-box binding protein 1 Homo sapiens 153-176 33396378-6 2020 In the ER, TNFalpha selectively phosphorylates inositol-requiring enzyme 1 alpha (pIRE1alpha) triggering downstream splicing of the transcription factor X-box binding protein 1 (XBP1s); thus, activating the pIRE1alpha/XBP1s ER stress pathway. Inositol 47-55 X-box binding protein 1 Homo sapiens 178-182 33334002-7 2020 The naturally occurring inositols display insulin-sensitizing effects and may be also used in this context because of their safety profile. Inositol 24-33 insulin Homo sapiens 42-49 33280430-2 2022 Inositols and their derivatives are involved in glucose and lipid metabolism and participate in insulin-signaling, with perturbations in inositol processing being associated with conditions involving insulin resistance, dysglycemia and dyslipidemia such as polycystic ovary syndrome and diabetes. Inositol 0-9 insulin Homo sapiens 96-103 33280430-2 2022 Inositols and their derivatives are involved in glucose and lipid metabolism and participate in insulin-signaling, with perturbations in inositol processing being associated with conditions involving insulin resistance, dysglycemia and dyslipidemia such as polycystic ovary syndrome and diabetes. Inositol 137-145 insulin Homo sapiens 200-207 33280430-5 2022 Inositol supplementation has shown promise as an intervention for the alleviation of symptoms in conditions of insulin resistance and for gestational diabetes prevention. Inositol 0-8 insulin Homo sapiens 111-118 33052067-0 2020 Inositol requiring enzyme 1 alpha (IRE1a) links palmitate-induced mTOR activation and lipotoxicity in Hepatocytes. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 35-40 33052067-0 2020 Inositol requiring enzyme 1 alpha (IRE1a) links palmitate-induced mTOR activation and lipotoxicity in Hepatocytes. Inositol 0-8 mechanistic target of rapamycin kinase Homo sapiens 66-70 32518291-7 2020 CBU engraftment, with CD33 and CD3 >5% cord chimerism in the myeloid/lymphoid compartment by day +60, occurred in 20 of 24 patients (83%). Inositol 0-3 CD33 molecule Homo sapiens 22-26 32070174-3 2020 This review provides an overview of recent progress in unfolded protein response (UPR) during apoptosis induced by abnormal protein aggregation and emphasizes on the potential role of inositol requiring enzyme 1 alpha (IRE1alpha)-microRNAs (miRNAs) mediated apoptosis in NDs, which will provide new insights in the pathogenesis of neurodegenerative diseases and novel therapeutic targets for the treatment of NDs. Inositol 184-192 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 219-228 32861679-1 2020 IRE1alpha (inositol requiring enzyme 1 alpha) is one of the main transducers of the unfolded protein response (UPR). Inositol 11-19 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 0-9 33257696-6 2020 MINPP1 deficiency results in an intracellular imbalance of the inositol polyphosphate metabolism. Inositol 63-71 multiple inositol-polyphosphate phosphatase 1 Homo sapiens 0-6 32967966-4 2020 In addition, sufficient ER retention time was crucial for GPI-inositol deacylation, which is mediated by post-GPI attachment protein 1 (PGAP1). Inositol 62-70 epiregulin Homo sapiens 24-26 32967966-4 2020 In addition, sufficient ER retention time was crucial for GPI-inositol deacylation, which is mediated by post-GPI attachment protein 1 (PGAP1). Inositol 62-70 post-GPI attachment to proteins inositol deacylase 1 Homo sapiens 105-134 32967966-4 2020 In addition, sufficient ER retention time was crucial for GPI-inositol deacylation, which is mediated by post-GPI attachment protein 1 (PGAP1). Inositol 62-70 post-GPI attachment to proteins inositol deacylase 1 Homo sapiens 136-141 32967966-7 2020 ER stress induced surface expression of misfolded GPI-APs, but proper GPI-inositol deacylation occurred due to the extended time that they were retained in the ER. Inositol 74-82 epiregulin Homo sapiens 160-162 32967966-8 2020 Our results indicate that calnexin-mediated ER quality control systems for GPI-APs are necessary for both protein folding and GPI-inositol deacylation. Inositol 130-138 calnexin Homo sapiens 26-34 32967966-8 2020 Our results indicate that calnexin-mediated ER quality control systems for GPI-APs are necessary for both protein folding and GPI-inositol deacylation. Inositol 130-138 epiregulin Homo sapiens 44-46 33260918-2 2020 Both inositols have a role in insulin signaling and hormonal synthesis in the ovaries. Inositol 5-14 insulin Homo sapiens 30-37 33238508-10 2020 Moreover, the mRNA expression of genes related to lipid catabolism (CPT, ATGL, PPAR-alpha) was significantly up-regulated with the increase of dietary MI levels despite dietary carbohydrate levels. Inositol 151-153 peroxisome proliferator-activated receptor alpha Oreochromis niloticus 79-89 33298866-3 2020 This study characterizes mechanisms by which inositol requiring enzyme-1alpha (IRE1alpha), a UPR transducer, regulates proteostasis in GECs. Inositol 45-53 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 79-88 33173184-8 2021 IMPase and GSK-3beta activity was inhibited in Li2CO3-treated maternal and embryonic neural tissues (P < 0.01 and P < 0.05, respectively), along with decreased levels of inositol and metabolites, compared with control groups (P < 0.01). Inositol 170-178 glycogen synthase kinase 3 alpha Mus musculus 11-20 33159038-7 2020 These ASEs occur in genes enriched in PTEN signaling, inositol metabolism, and several other pathways relevant to the pathophysiology of ASD. Inositol 54-62 phosphatase and tensin homolog Mus musculus 38-42 32770354-5 2020 In PCOS patients, COC treatment modified the hormonal profile and worsened lipid parameters (increasing cholesterol and triglyceride levels) and insulin resistance, whereas inositol therapies improved significantly insulin resistance and glycosylated hemoglobin, reducing cholesterol and triglyceride levels. Inositol 173-181 insulin Homo sapiens 215-222 33254564-0 2020 Role of inositol to improve surfactant functions and reduce IL-6 levels: A potential adjuvant strategy for SARS-CoV-2 pneumonia? Inositol 8-16 interleukin 6 Homo sapiens 60-64 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 interleukin 6 Homo sapiens 72-76 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 135-162 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 164-168 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 X-box binding protein 1 Homo sapiens 170-193 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 X-box binding protein 1 Homo sapiens 195-199 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 signal transducer and activator of transcription 3 Homo sapiens 212-262 33254564-5 2020 In addition, myo-inositol has been found able to decrease the levels of IL-6 in several experimental settings, due to an effect on the inositol-requiring enzyme 1 (IRE1)-X-box-binding protein 1 (XBP1) and on the signal transducer and activator of transcription 3 (STAT3) pathways. Inositol 13-25 signal transducer and activator of transcription 3 Homo sapiens 264-269 33254564-6 2020 In this scenario, treatment with myo-inositol may be able to reduce IL-6 dependent inflammatory response and improve oxygenation in patients with severe ARDS by SARS-CoV-2. Inositol 33-45 interleukin 6 Homo sapiens 68-72 33254564-7 2020 In addition, the action of myo-inositol on IRE1 endonuclease activity may also inhibit the replication of SARS-CoV-2, as was reported for the respiratory syncytial virus. Inositol 27-39 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 43-47 32799639-3 2020 The inositol requiring enzyme (IRE1) is one ER stress sensor that is activated to splice the bZIP60 mRNA which produces a truncated transcription factor that activates gene expression in the nucleus. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 31-35 32927152-0 2020 Inositol-requiring enzyme 1 (IRE1) plays for AvrRpt2-triggered immunity and RIN4 cleavage in Arabidopsis under endoplasmic reticulum (ER) stress. Inositol 0-8 RPM1 interacting protein 4 Arabidopsis thaliana 76-80 33020399-0 2020 Direct Effects of D-Chiro-Inositol on Insulin Signaling and Glucagon Secretion of Pancreatic Alpha Cells. Inositol 18-34 insulin Homo sapiens 38-45 33020399-3 2020 The aim of this study was to investigate the preventive role of D-chiro-inositol (DCI), which has insulin receptor-sensitizer effects on insulin signaling pathways and glucagon secretion in pancreatic alpha-TC1 clone 6 cells. Inositol 64-80 insulin receptor Mus musculus 98-114 33020399-3 2020 The aim of this study was to investigate the preventive role of D-chiro-inositol (DCI), which has insulin receptor-sensitizer effects on insulin signaling pathways and glucagon secretion in pancreatic alpha-TC1 clone 6 cells. Inositol 64-80 insulin Homo sapiens 98-105 33020399-3 2020 The aim of this study was to investigate the preventive role of D-chiro-inositol (DCI), which has insulin receptor-sensitizer effects on insulin signaling pathways and glucagon secretion in pancreatic alpha-TC1 clone 6 cells. Inositol 64-80 glucagon Mus musculus 168-176 33090422-0 2020 Enhancement of D-chiro-inositol transport across intestinal cells by alpha-Lactalbumin peptides. Inositol 15-31 lactalbumin alpha Homo sapiens 69-86 33090422-2 2020 D-chiro-inositol, one of the natural occurring stereoisomer of myo-inositol, acts as a second messenger in insulin-regulated glucose metabolism in complementary mode with myo-inositol. Inositol 0-16 insulin Homo sapiens 107-114 33090422-2 2020 D-chiro-inositol, one of the natural occurring stereoisomer of myo-inositol, acts as a second messenger in insulin-regulated glucose metabolism in complementary mode with myo-inositol. Inositol 63-75 insulin Homo sapiens 107-114 33090422-2 2020 D-chiro-inositol, one of the natural occurring stereoisomer of myo-inositol, acts as a second messenger in insulin-regulated glucose metabolism in complementary mode with myo-inositol. Inositol 171-183 insulin Homo sapiens 107-114 33090422-3 2020 Because of their insulin-mimetic activities and safety, both myo-inositol and D-chiro-inositol are often employed as supplements in insulin-resistance treatment. Inositol 61-73 insulin Homo sapiens 17-24 33090422-3 2020 Because of their insulin-mimetic activities and safety, both myo-inositol and D-chiro-inositol are often employed as supplements in insulin-resistance treatment. Inositol 61-73 insulin Homo sapiens 132-139 33090422-3 2020 Because of their insulin-mimetic activities and safety, both myo-inositol and D-chiro-inositol are often employed as supplements in insulin-resistance treatment. Inositol 78-94 insulin Homo sapiens 17-24 33090422-3 2020 Because of their insulin-mimetic activities and safety, both myo-inositol and D-chiro-inositol are often employed as supplements in insulin-resistance treatment. Inositol 78-94 insulin Homo sapiens 132-139 33090422-6 2020 alpha-Lactalbumin peptides, obtained by in vitro simulated gastrointestinal digestion, were tested as possible modulators of the intestinal permeability of D-chiro-inositol. Inositol 156-172 lactalbumin alpha Homo sapiens 0-17 32933338-8 2021 Our data indicate that IP6 and INS enhanced the effect of capecitabine on CRC growth in mice by modulating the expression of inflammatory factors, intercellular adhesion molecules, and vimentin. Inositol 31-34 vimentin Mus musculus 185-193 32901024-6 2020 The longevity effect of MI is dependent on the tumor suppressor gene, daf-18 (homologous to mouse Pten), independent of its classical pathway downstream genes, akt or daf-16. Inositol 24-26 phosphatase and tensin homolog Mus musculus 98-102 32901024-7 2020 Furthermore, we found MI effects on aging and lifespan act through mitophagy regulator PTEN induced kinase-1 (pink-1) and mitophagy. Inositol 22-24 PTEN induced putative kinase 1 Mus musculus 87-108 32901024-7 2020 Furthermore, we found MI effects on aging and lifespan act through mitophagy regulator PTEN induced kinase-1 (pink-1) and mitophagy. Inositol 22-24 PTEN induced putative kinase 1 Mus musculus 110-116 32593899-8 2020 Using Mfn2 siRNA or inositol-requiring enzyme 1 alpha (IRE1alpha) inhibitor, we found NASH and ferroptosis were obviously mitigated through reducing 5-HETE content. Inositol 20-28 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 55-64 32705733-7 2020 Evaluated together as joint predictors, serum albumin but not Gln/tCr significantly predicted mI/tCr in GM (P = .02 and P = .2, respectively) and PWM (P = .01 and P = .1, respectively). Inositol 94-96 albumin Homo sapiens 40-53 32705733-9 2020 Low serum albumin was the strongest predictor of brain osmotic stress indicated by reduced mI/tCr, with no residual independent association seen for brain Gln/tCr concentration. Inositol 91-93 albumin Homo sapiens 10-17 32590101-5 2020 Inositols were administered as mixture of myo-inositol and D-chiro-inositol in the drinking water. Inositol 0-9 synaptopodin 2 Mus musculus 42-45 32878237-1 2020 BACKGROUND: Inositol-requiring enzyme 1alpha (IRE1alpha), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein response (UPR). Inositol 12-20 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 46-55 32878237-1 2020 BACKGROUND: Inositol-requiring enzyme 1alpha (IRE1alpha), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein response (UPR). Inositol 12-20 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 69-119 32878237-1 2020 BACKGROUND: Inositol-requiring enzyme 1alpha (IRE1alpha), along with protein kinase R-like endoplasmic reticulum kinase (PERK), is a principal regulator of the unfolded protein response (UPR). Inositol 12-20 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 121-125 32839513-3 2021 IMPA1 is responsible for the generation of free inositol from de novo biosynthesis and recycling from inositol polyphosphates and participates in the phosphatidylinositol signaling pathway. Inositol 48-56 inositol monophosphatase 1 Homo sapiens 0-5 32825356-8 2020 This work presents a critical review of inositol actions on insulin signaling, oxidative stress, and endothelial dysfunction, and its potential for either preventing or delaying cognitive impairment in aging and neurodegenerative diseases. Inositol 40-48 insulin Homo sapiens 60-67 32631512-4 2020 In this study, we have designed and synthesized new phosphate derivatives of Myo-inositol to inhibit the oncogenic KRAS pathway in breast cancer cells, which has been validated by cellular and theoretical studies. Inositol 77-89 KRAS proto-oncogene, GTPase Homo sapiens 115-119 32267539-6 2020 In the MTHFR group, 1-monohexadecanoylglycerol, pyrophosphate, benzoin, and linoleic acid were found to be significantly decreased (p 0.05 for all), whereas glyceric acid, L-tryptophan, L-alanine, L-proline, norvaline, L-threonine, and myo-inositol were significantly increased (p 0.01 for the first 2 metabolites, p 0.05 for the others) at 11-14 gestational weeks. Inositol 238-250 methylenetetrahydrofolate reductase Homo sapiens 7-12 32552009-2 2020 However, information about d-chiro-inositol (DCI) is still scarce, despite the ratio MI:DCI is tissue-specific and actively maintained by an insulin-dependent epimerase enzyme. Inositol 27-43 insulin Homo sapiens 141-148 32894558-8 2020 CONCLUSIONS: The supplementation of MI in combination with melatonin in the first 3 months before oocyte pick up and with vitamin D3 in the further 3 months could represent an innovative support for all those women undergoing ICSI. Inositol 36-38 protein interacting with PRKCA 1 Homo sapiens 105-109 32418411-12 2020 Indeed, emerging data support inositol and alpha-lipoic acid as alternative compounds, alone or in combination with the aforementioned strategies, with favourable effects on ovulation, insulin resistance and inflammation. Inositol 30-38 insulin Homo sapiens 185-192 32390256-3 2020 The inositol requiring enzyme (IRE1) is one ER stress sensor that is activated to splice the bZIP60 mRNA which produces a truncated transcription factor that activates gene expression in the nucleus. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 31-35 32418772-1 2020 It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). Inositol 22-34 insulin Homo sapiens 71-78 32418772-1 2020 It is well known that myo-inositol (MI) and D-chiro-inositol (DCI) are insulin-sensitizing agents, and MI is of proven utility in polycystic ovary syndrome (PCOS). Inositol 44-60 insulin Homo sapiens 71-78 32751795-9 2020 An acute unfolded protein response (UPR) was triggered shortly after VAS3947 exposure, through the activation of inositol-requiring enzyme 1alpha (IRE1alpha) and PKR-like endoplasmic reticulum kinase (PERK) pathways. Inositol 113-121 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 147-156 32646482-0 2020 Effect of dietary myo-inositol supplementation on the insulin resistance and the prevention of gestational diabetes mellitus: study protocol for a randomized controlled trial. Inositol 18-30 insulin Homo sapiens 54-61 32646482-3 2020 Myo-inositol has been suggested to improve insulin resistance in women with polycystic ovary syndrome. Inositol 0-12 insulin Homo sapiens 43-50 32647331-0 2020 Involvement of Arabidopsis BIG protein in cell death mediated by Myo-inositol homeostasis. Inositol 65-77 auxin transport protein (BIG) Arabidopsis thaliana 27-30 31925927-1 2020 AIMS/INTRODUCTION: Under irremediable endoplasmic reticulum (ER) stress, hyperactivated inositol-requiring enzyme 1alpha (IRE1alpha) triggers the terminal unfolded protein response (T-UPR), causing crucial cell dysfunction and apoptosis. Inositol 88-96 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 122-131 32277979-9 2020 Similarly, it boosted inositol requiring enzyme-1alpha (IRE1alpha) activation and redox imbalance. Inositol 22-30 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 56-65 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 53-62 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 interleukin 6 Mus musculus 191-204 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 interleukin 6 Mus musculus 206-210 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 interleukin 23, alpha subunit p19 Mus musculus 213-218 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 arginase, liver Mus musculus 220-229 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 CD86 antigen Mus musculus 264-268 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 CD274 antigen Mus musculus 273-298 32520957-3 2020 Here we report that the inositol-requiring enzyme 1 (IRE1alpha) branch of the UPR is directly involved in the polarization of macrophages in vitro and in vivo, including the up-regulation of interleukin 6 (IL-6), IL-23, Arginase1, as well as surface expression of CD86 and programmed death ligand 1 (PD-L1). Inositol 24-32 CD274 antigen Mus musculus 300-305 32587614-14 2020 Myo-inositol supplementation was associated with lower insulin levels, glucose levels, and insulin resistance when compared with placebo, metformin, or estrogen treatments. Inositol 0-12 insulin Homo sapiens 55-62 32587614-14 2020 Myo-inositol supplementation was associated with lower insulin levels, glucose levels, and insulin resistance when compared with placebo, metformin, or estrogen treatments. Inositol 0-12 insulin Homo sapiens 91-98 32587614-15 2020 Conclusions: The use of insulin-sensitizing agents, such as metformin and inositols, along with lifestyle interventions may improve the metabolic profile in PCOS women. Inositol 74-83 insulin Homo sapiens 24-31 32363653-4 2020 This pathway relies on the presence of two transducers of the unfolded protein response: inositol-requiring enzyme-1a (IRE1alpha) and protein kinase R-like ER kinase (PERK). Inositol 89-97 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 119-128 31827236-4 2020 SPHK1 deficiency alleviated APAP-induced endoplasmic reticulum (ER) stress by affecting the phosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) and protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor 2alpha (eIF2alpha), levels of activating transcription factor 4 (ATF4), and activation of activating transcription factor 6 (ATF6). Inositol 111-119 sphingosine kinase 1 Mus musculus 0-5 31827236-4 2020 SPHK1 deficiency alleviated APAP-induced endoplasmic reticulum (ER) stress by affecting the phosphorylation of inositol-requiring enzyme 1alpha (IRE1alpha) and protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)-eukaryotic translation initiation factor 2alpha (eIF2alpha), levels of activating transcription factor 4 (ATF4), and activation of activating transcription factor 6 (ATF6). Inositol 111-119 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 145-154 32102897-5 2020 We observed that HSP47 forms a complex with both the UPR transducer inositol-requiring enzyme 1alpha (IRE1alpha) and ER chaperone BiP in cancer cells. Inositol 68-76 serpin family H member 1 Homo sapiens 17-22 32102897-5 2020 We observed that HSP47 forms a complex with both the UPR transducer inositol-requiring enzyme 1alpha (IRE1alpha) and ER chaperone BiP in cancer cells. Inositol 68-76 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 102-111 32396844-1 2020 This review details the physiologic roles of two insulin sensitizers, myo-inositol (MI) and d-chiro-inositol (DCI). Inositol 70-82 insulin Homo sapiens 49-56 32396844-1 2020 This review details the physiologic roles of two insulin sensitizers, myo-inositol (MI) and d-chiro-inositol (DCI). Inositol 92-108 insulin Homo sapiens 49-56 32396844-5 2020 As impaired intestinal transport may lead to unsuccessful inositol treatment, we also discuss new data on the use of alpha-lactalbumin to boost inositol absorption. Inositol 144-152 lactalbumin alpha Homo sapiens 117-134 31730952-1 2020 Myo-inositol monophosphatase (IMP) is a crucial enzyme in the inositol biosynthetic pathway that dephosphorylates myo-inositol 1-phosphate and other inositol phosphate derivative compounds to maintain the homeostasis of cellular inositol pool. Inositol 4-12 myo-inositol monophosphatase Cicer arietinum 30-33 31730952-1 2020 Myo-inositol monophosphatase (IMP) is a crucial enzyme in the inositol biosynthetic pathway that dephosphorylates myo-inositol 1-phosphate and other inositol phosphate derivative compounds to maintain the homeostasis of cellular inositol pool. Inositol 62-70 myo-inositol monophosphatase Cicer arietinum 0-28 31730952-1 2020 Myo-inositol monophosphatase (IMP) is a crucial enzyme in the inositol biosynthetic pathway that dephosphorylates myo-inositol 1-phosphate and other inositol phosphate derivative compounds to maintain the homeostasis of cellular inositol pool. Inositol 62-70 myo-inositol monophosphatase Cicer arietinum 30-33 32413098-2 2020 INPP4B dephosphorylates phospholipids at the 4th position of the inositol ring and inhibits AKT and PKC signaling by hydrolyzing of PI(3,4)P2 and PI(4,5)P2, respectively. Inositol 65-73 inositol polyphosphate-4-phosphatase, type II Mus musculus 0-6 31897490-6 2020 Reduced myoinositol content was localized to the infralimbic (IL) cortex, where significant reductions in transcript levels of key proteins involved in the synthesis and recycling of myoinositol (IMPase1) were also present. Inositol 8-19 inositol monophosphatase 1 Rattus norvegicus 196-203 31897490-6 2020 Reduced myoinositol content was localized to the infralimbic (IL) cortex, where significant reductions in transcript levels of key proteins involved in the synthesis and recycling of myoinositol (IMPase1) were also present. Inositol 183-194 inositol monophosphatase 1 Rattus norvegicus 196-203 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 8-10 interleukin 1 alpha Homo sapiens 40-48 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 8-10 tumor necrosis factor Homo sapiens 50-53 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 8-10 interleukin 6 Homo sapiens 58-62 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 15-17 interleukin 1 alpha Homo sapiens 40-48 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 15-17 tumor necrosis factor Homo sapiens 50-53 32049375-7 2020 The MCI/MI- or MI- induced secretion of IL-1beta, TNF and IL-6 by PBMC was analysed by flow cytometry. Inositol 15-17 interleukin 6 Homo sapiens 58-62 32049375-8 2020 RESULTS: The results showed a decreased TLR4 expression with upregulated IL6, FOXP3, IL10 and TGFbeta mRNA expression as assessed by q-PCR at the site of the MCI/MI skin reaction. Inositol 162-164 toll like receptor 4 Homo sapiens 40-44 32693897-24 2020 01) and the expression levels of GK and GLUT4 genes in the 75 mug/mL inositol group were significantly increased(P<0. Inositol 69-77 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 40-45 32693897-29 2020 CONCLUSION: Mannose and inositol can improve the expression of GLUT4 mRNA, which may help to increase glucose uptake by peripheral cells. Inositol 24-32 solute carrier family 2 (facilitated glucose transporter), member 4 Mus musculus 63-68 32061752-3 2020 The inositol-requiring enzyme 1alpha (IRE1alpha), an arm of unfolded protein response (UPR), splices XBP1 mRNA to generate an active transcription factor XBP1s. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 38-47 32061752-3 2020 The inositol-requiring enzyme 1alpha (IRE1alpha), an arm of unfolded protein response (UPR), splices XBP1 mRNA to generate an active transcription factor XBP1s. Inositol 4-12 X-box binding protein 1 Homo sapiens 101-105 32368081-0 2020 Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/beta-Catenin Pathway. Inositol 15-23 wingless-type MMTV integration site family, member 10B Mus musculus 118-121 32368081-0 2020 Combination of Inositol Hexaphosphate and Inositol Inhibits Liver Metastasis of Colorectal Cancer in Mice Through the Wnt/beta-Catenin Pathway. Inositol 15-23 catenin (cadherin associated protein), beta 1 Mus musculus 122-134 32242600-2 2020 The Ac2Lys moiety blocking the inositol 1-O-position required for GPI biosynthesis was expected to be removable by a combination of two enzymes, histone deacetylase (HDAC) and cathepsin L (CTSL), abundantly expressed in cancer cells, but not in normal cells, to transform these inositol derivatives into biosynthetically useful products with a free 1-O-position. Inositol 31-39 cathepsin L Homo sapiens 176-187 32242600-2 2020 The Ac2Lys moiety blocking the inositol 1-O-position required for GPI biosynthesis was expected to be removable by a combination of two enzymes, histone deacetylase (HDAC) and cathepsin L (CTSL), abundantly expressed in cancer cells, but not in normal cells, to transform these inositol derivatives into biosynthetically useful products with a free 1-O-position. Inositol 31-39 cathepsin L Homo sapiens 189-193 32242600-2 2020 The Ac2Lys moiety blocking the inositol 1-O-position required for GPI biosynthesis was expected to be removable by a combination of two enzymes, histone deacetylase (HDAC) and cathepsin L (CTSL), abundantly expressed in cancer cells, but not in normal cells, to transform these inositol derivatives into biosynthetically useful products with a free 1-O-position. Inositol 278-286 cathepsin L Homo sapiens 176-187 32242600-2 2020 The Ac2Lys moiety blocking the inositol 1-O-position required for GPI biosynthesis was expected to be removable by a combination of two enzymes, histone deacetylase (HDAC) and cathepsin L (CTSL), abundantly expressed in cancer cells, but not in normal cells, to transform these inositol derivatives into biosynthetically useful products with a free 1-O-position. Inositol 278-286 cathepsin L Homo sapiens 189-193 32290029-7 2020 We demonstrated that an IP6 and inositol combination supplement may regulate insulin secretion, modulate serum leptin concentrations, food intake, and associated weight gain, which may be beneficial in both prediabetic and diabetic states. Inositol 32-40 insulin Homo sapiens 77-84 32290029-7 2020 We demonstrated that an IP6 and inositol combination supplement may regulate insulin secretion, modulate serum leptin concentrations, food intake, and associated weight gain, which may be beneficial in both prediabetic and diabetic states. Inositol 32-40 leptin Homo sapiens 111-117 32252239-0 2020 Targeting Metabolic Consequences of Insulin Resistance in Polycystic Ovary Syndrome by D-chiro-inositol and Emerging Nutraceuticals: A Focused Review. Inositol 87-103 insulin Homo sapiens 36-43 32252239-6 2020 D-chiro-inositol (DCI), which is a naturally occurring stereoisomer of inositol, has been classified as an insulin-sensitizer and seems to mitigate multiple InsR-related metabolic alterations in PCOS with a safe profile. Inositol 0-16 insulin Homo sapiens 107-114 32252239-6 2020 D-chiro-inositol (DCI), which is a naturally occurring stereoisomer of inositol, has been classified as an insulin-sensitizer and seems to mitigate multiple InsR-related metabolic alterations in PCOS with a safe profile. Inositol 0-16 insulin receptor Homo sapiens 157-161 32252239-6 2020 D-chiro-inositol (DCI), which is a naturally occurring stereoisomer of inositol, has been classified as an insulin-sensitizer and seems to mitigate multiple InsR-related metabolic alterations in PCOS with a safe profile. Inositol 8-16 insulin Homo sapiens 107-114 32252239-6 2020 D-chiro-inositol (DCI), which is a naturally occurring stereoisomer of inositol, has been classified as an insulin-sensitizer and seems to mitigate multiple InsR-related metabolic alterations in PCOS with a safe profile. Inositol 8-16 insulin receptor Homo sapiens 157-161 31927142-6 2020 Considering that massive synthesis of proteins and/or lipids may drive to ER stress, herein we evaluated whether hyperosmolar environment induces ER stress and the participation of inositol-requiring enzyme 1alpha (IRE1alpha)-XBP1 in hyperosmotic-induced lipid synthesis. Inositol 181-189 X-box-binding protein 1 Canis lupus familiaris 226-230 31950225-6 2020 miR-155 upregulation associates with reduced levels of SHIP-1 inositol phosphatase, which acts in constraining PI3K-dependent signals, by virtue of its ability to mediate phosphatidylinositol 3,4,5-trisphosphate (PIP3) de-phosphorylation. Inositol 62-70 microRNA 155 Homo sapiens 0-7 32226566-4 2020 To improve the performance in the early stages of MI training, a novel hybrid BCI paradigm based on MI and P300 is proposed in this study. Inositol 50-52 E1A binding protein p300 Homo sapiens 107-111 32028152-3 2020 Real-time PCR and Western Blot were used to detect the protein and mRNA expression levels of inositol-1,4,5-triphate-receptor (IP3R) and epithelial-mesenchymal-transition (EMT)-related molecular markers, such as E-cadherin, beta-Catenin, Snail, N-cadherin, in the GT of hypospadiac male rats and controls. Inositol 93-116 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 127-131 32223896-6 2020 Therapeutically, functional studies demonstrated gene therapy-delivered cardiac-specific MAPK7 restoration or overexpression of CEBPbeta impeded cardiac injury after MI, at least partly due to normalization of mir128-3p. Inositol 166-168 mitogen-activated protein kinase 7 Homo sapiens 89-94 32223896-6 2020 Therapeutically, functional studies demonstrated gene therapy-delivered cardiac-specific MAPK7 restoration or overexpression of CEBPbeta impeded cardiac injury after MI, at least partly due to normalization of mir128-3p. Inositol 166-168 CCAAT enhancer binding protein alpha Homo sapiens 128-136 32256563-2 2020 Inositol and associated molecules display inhibitory properties against 5-alpha reductase, COX-2, and lipase enzymes in addition to their antimicrobial and anti-inflammatory properties. Inositol 0-8 mitochondrially encoded cytochrome c oxidase II Homo sapiens 91-96 32191130-4 2020 Significant alteration in MIOX activity was found between 0- and 2-h in Group 3 compared to Groups 1 and 2 (p < .029).Conclusions: MIOX levels were higher in GDM cases so, it may be have a role in myo-inositol catabolism. Inositol 197-209 myo-inositol oxygenase Homo sapiens 26-30 32191130-4 2020 Significant alteration in MIOX activity was found between 0- and 2-h in Group 3 compared to Groups 1 and 2 (p < .029).Conclusions: MIOX levels were higher in GDM cases so, it may be have a role in myo-inositol catabolism. Inositol 197-209 myo-inositol oxygenase Homo sapiens 131-135 32271462-7 2020 Myo-Inositol proved to reduce IL-6 levels in a number of conditions and to mitigate the inflammatory cascade, while being devoid of any significant side effects. Inositol 0-12 interleukin 6 Homo sapiens 30-34 32129111-3 2020 Updates include new evidence on the efficacy exerted in PCOS by the 40:1 MI/DCI ratio, and the innovative approach based on alpha-lactalbumin to overcome the decreased therapeutic efficacy of Inositols in some patients.Expert opinion: The evidence suggests that MI, alone or with DCI in the 40:1 ratio, offers a promising treatment for PCOS and NIDDM. Inositol 192-201 lactalbumin alpha Homo sapiens 124-141 31904542-1 2020 Apart from mitigating endoplasmic reticulum (ER) stress, vast studies have demonstrated the crucial role of inositol-requiring transmembrane kinase and endonuclease 1alpha (IRE1alpha) - spliced X-box binding protein 1 (XBP1s) signaling pathway in inflammatory response in mammals. Inositol 108-116 LOW QUALITY PROTEIN: X-box-binding protein 1 Larimichthys crocea 194-217 31846435-1 2020 The induction of endoplasmic reticulum (ER) stress is associated with adipogenesis, during which the inositol-requiring enzyme 1 alpha (IRE1alpha) -X-box binding protein 1 (XBP1) pathway is involved. Inositol 101-109 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 136-145 31846435-1 2020 The induction of endoplasmic reticulum (ER) stress is associated with adipogenesis, during which the inositol-requiring enzyme 1 alpha (IRE1alpha) -X-box binding protein 1 (XBP1) pathway is involved. Inositol 101-109 X-box binding protein 1 Mus musculus 148-171 31846435-1 2020 The induction of endoplasmic reticulum (ER) stress is associated with adipogenesis, during which the inositol-requiring enzyme 1 alpha (IRE1alpha) -X-box binding protein 1 (XBP1) pathway is involved. Inositol 101-109 X-box binding protein 1 Mus musculus 173-177 30558466-1 2020 OBJECTIVE: To identify the effects of different dietary inositol stereoisomers on insulin resistance and the development of gestational diabetes mellitus (GDM) in women at high risk for this disorder. Inositol 56-64 insulin Homo sapiens 82-89 32110869-8 2020 The MI group showed a significantly increased expression of CD45 compared with the control group (p < 0.05). Inositol 4-6 protein tyrosine phosphatase, receptor type, C Mus musculus 60-64 31874063-0 2020 The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment. Inositol 37-49 insulin Homo sapiens 4-11 31874063-0 2020 The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment. Inositol 37-49 protein kinase AMP-activated catalytic subunit alpha 1 Homo sapiens 69-73 31874063-0 2020 The insulin-sensitizing mechanism of myo-inositol is associated with AMPK activation and GLUT-4 expression in human endometrial cells exposed to a PCOS environment. Inositol 37-49 solute carrier family 2 member 4 Homo sapiens 89-95 31874063-3 2020 Myo-inositol (MYO) is an insulin-sensitizing compound used in PCOS patients; however, its insulin-sensitizing mechanism is unclear. Inositol 0-12 insulin Homo sapiens 25-32 31874063-3 2020 Myo-inositol (MYO) is an insulin-sensitizing compound used in PCOS patients; however, its insulin-sensitizing mechanism is unclear. Inositol 0-12 insulin Homo sapiens 90-97 31874063-3 2020 Myo-inositol (MYO) is an insulin-sensitizing compound used in PCOS patients; however, its insulin-sensitizing mechanism is unclear. Inositol 14-17 insulin Homo sapiens 25-32 31678512-5 2020 This change triggers a signaling cascade transmitted to cytosolic diphosphoinositol phosphate derivatives, among them 5-PP-IP4 and 1-IP7, that exert regulatory functions on genes involved in the inositol and phospholipids (PLs) metabolism, and inhibit the activity of the protein kinase Pho85. Inositol 75-83 cyclin-dependent serine/threonine-protein kinase PHO85 Saccharomyces cerevisiae S288C 287-292 31776016-7 2020 In addition, we found that Aroclor 1254 administration induced oxidative stress in mouse liver and elevated the protein level of cyclooxygenase 2 (COX-2), an inflammatory molecule, possibly via the endoplasmic reticulum (ER) stress inositol-requiring enzyme 1alpha-X-box-binding protein-1 (IRE1alpha-XBP1) pathway, but not the nuclear factor-kappaB (NF-kappaB) pathway. Inositol 232-240 prostaglandin-endoperoxide synthase 2 Mus musculus 129-145 31776016-7 2020 In addition, we found that Aroclor 1254 administration induced oxidative stress in mouse liver and elevated the protein level of cyclooxygenase 2 (COX-2), an inflammatory molecule, possibly via the endoplasmic reticulum (ER) stress inositol-requiring enzyme 1alpha-X-box-binding protein-1 (IRE1alpha-XBP1) pathway, but not the nuclear factor-kappaB (NF-kappaB) pathway. Inositol 232-240 prostaglandin-endoperoxide synthase 2 Mus musculus 147-152 31907997-1 2020 Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is a target of miR-155, a pro-inflammatory factor. Inositol 26-34 inositol polyphosphate-5-phosphatase D Mus musculus 50-56 31907997-1 2020 Src Homology 2-containing Inositol Phosphatase-1 (SHIP-1) is a target of miR-155, a pro-inflammatory factor. Inositol 26-34 microRNA 155 Mus musculus 73-80 31778727-6 2020 Furthermore, tan IIA significantly reduced the deposition of Abeta plaques and neuronal apoptosis, and markedly prevented abnormal expression of glucose regulated protein 78 (GRP78), initiation factor 2alpha (eIF2alpha), inositol-requiring enzyme 1alpha (IRE1alpha), activating transcription factor 6 (ATF6), as well as suppressed the activation of C/EBP homologous protein (CHOP) and c-Jun N-terminal kinase (JNK) pathways in the parietal cortex and hippocampus. Inositol 221-229 ATPase, class II, type 9A Mus musculus 17-20 31949037-1 2020 In CA1 neurons of guinea pig hippocampal slices, long-term potentiation (LTP) was induced in field excitatory postsynaptic potentials (EPSPs) or population spikes (PSs) by the delivery of high-frequency stimulation (HFS, 100 pulses at 100 Hz) to CA1 synapses, and was reversed by the delivery of a train of low-frequency stimulation (LFS, 1000 pulses at 2 Hz) at 30 min after HFS (depotentiation), and this effect was inhibited when test synaptic stimulation was halted for a 19-min period after HFS or for a 20-min period after LFS or applied over the same time period in the presence of an antagonist of N-methyl-D-aspartate receptors (NMDARs), group I metabotropic glutamate receptors (mGluRs), or inositol 1, 4, 5-trisphosphate receptors (IP3Rs). Inositol 701-709 carbonic anhydrase 1 Cavia porcellus 3-6 31936679-11 2020 To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. Inositol 136-144 activating transcription factor 6 Homo sapiens 232-236 31936679-11 2020 To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. Inositol 136-144 activating transcription factor 4 Homo sapiens 243-276 31936679-11 2020 To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. Inositol 136-144 activating transcription factor 4 Homo sapiens 277-281 31936679-11 2020 To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. Inositol 136-144 tumor protein p53 Homo sapiens 305-308 31936679-11 2020 To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. Inositol 136-144 BCL2 associated X, apoptosis regulator Homo sapiens 310-313 31936679-11 2020 To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. Inositol 136-144 caspase 3 Homo sapiens 319-328 31936679-11 2020 To further substantiate the mechanism of cell death mediated by endoplasmic reticulum stress (ERS), we determined the expression of the inositol-requiring enzyme (IRE1), (PKR-like ER kinase) PERK, activating transcription factor 6 (ATF6), and activating transcription factor 4 ATF4, the apoptotic markers p53, Bax, and caspase 3, and the anti-apoptotic marker Bcl-2. Inositol 136-144 BCL2 apoptosis regulator Homo sapiens 360-365 31900232-10 2020 Furthermore, we observed a higher splicing ratio of XBP1 (X-box binding protein 1) mRNA, indicating elevated inositol-requiring enzyme 1 (IRE-1) activity and, consequently, increased endoplasmic reticulum (ER) stress. Inositol 109-117 LOW QUALITY PROTEIN: X-box-binding protein 1 Equus caballus 52-56 31900232-10 2020 Furthermore, we observed a higher splicing ratio of XBP1 (X-box binding protein 1) mRNA, indicating elevated inositol-requiring enzyme 1 (IRE-1) activity and, consequently, increased endoplasmic reticulum (ER) stress. Inositol 109-117 LOW QUALITY PROTEIN: X-box-binding protein 1 Equus caballus 58-81 31648945-6 2020 One of the most important enzymes responsible for higher-order inositol phosphate synthesis is inositol polyphosphate multikinase (IPMK), which plays dual roles in both inositol and phosphoinositide signaling. Inositol 63-71 inositol polyphosphate multikinase Homo sapiens 95-129 31648945-6 2020 One of the most important enzymes responsible for higher-order inositol phosphate synthesis is inositol polyphosphate multikinase (IPMK), which plays dual roles in both inositol and phosphoinositide signaling. Inositol 63-71 inositol polyphosphate multikinase Homo sapiens 131-135 32418522-9 2020 Inositol stereoisomer"s namely, scylloinositol and Myo-inositol, have also been seen to inhibit Abeta production and plaque accumulation in the brain, inhibiting AD pathogenesis. Inositol 0-8 amyloid beta precursor protein Homo sapiens 96-101 32418522-9 2020 Inositol stereoisomer"s namely, scylloinositol and Myo-inositol, have also been seen to inhibit Abeta production and plaque accumulation in the brain, inhibiting AD pathogenesis. Inositol 51-63 amyloid beta precursor protein Homo sapiens 96-101 32115550-7 2020 Various potent IP3 receptor ligands, which were designed using the d-glucose structure as a bioisostere of the myo-inositol moiety of IP3, have been identified. Inositol 111-123 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 15-27 31611349-1 2019 Manogepix (MGX) targets the conserved fungal Gwt1 enzyme required for acylation of inositol early in the glycosylphosphatidylinositol biosynthesis pathway. Inositol 83-91 glucosaminyl-phosphotidylinositol O-acyltransferase Saccharomyces cerevisiae S288C 45-49 31921161-7 2019 Our data show that proteasome impairment by bortezomib is a stimulus that activates all three intracellular ER-stress transducers activation transcription factor 6, protein kinase R-like endoplasmic reticulum kinase and inositol-requiring protein 1 alpha (IRE1alpha), causing a full activation of the UPR. Inositol 220-228 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 256-265 31666338-1 2019 Inositol-requiring enzyme 1 (IRE1) is an endoplasmic reticulum (ER)-resident transmembrane protein that senses ER stress and is evolutionarily conserved from yeast to humans. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 29-33 31754032-4 2019 Inositol tetrakisphosphate 1-kinase 1 (ITPK1)-found in Asgard archaea, social amoeba, plants, and animals-phosphorylates I(3)P1 originating from glucose-6-phosphate, and I(1)P1 generated from sphingolipids, to enable synthesis of IP6 We also found using PAGE mass assay that metabolic blockage by phosphate starvation surprisingly increased IP6 levels in a ITPK1-dependent manner, establishing a route to IP6 controlled by cellular metabolic status, that is not detectable by traditional [3H]-inositol labeling. Inositol 488-501 inositol-tetrakisphosphate 1-kinase Homo sapiens 0-37 31754032-4 2019 Inositol tetrakisphosphate 1-kinase 1 (ITPK1)-found in Asgard archaea, social amoeba, plants, and animals-phosphorylates I(3)P1 originating from glucose-6-phosphate, and I(1)P1 generated from sphingolipids, to enable synthesis of IP6 We also found using PAGE mass assay that metabolic blockage by phosphate starvation surprisingly increased IP6 levels in a ITPK1-dependent manner, establishing a route to IP6 controlled by cellular metabolic status, that is not detectable by traditional [3H]-inositol labeling. Inositol 488-501 inositol-tetrakisphosphate 1-kinase Homo sapiens 39-44 31754032-4 2019 Inositol tetrakisphosphate 1-kinase 1 (ITPK1)-found in Asgard archaea, social amoeba, plants, and animals-phosphorylates I(3)P1 originating from glucose-6-phosphate, and I(1)P1 generated from sphingolipids, to enable synthesis of IP6 We also found using PAGE mass assay that metabolic blockage by phosphate starvation surprisingly increased IP6 levels in a ITPK1-dependent manner, establishing a route to IP6 controlled by cellular metabolic status, that is not detectable by traditional [3H]-inositol labeling. Inositol 488-501 inositol-tetrakisphosphate 1-kinase Homo sapiens 357-362 31578081-8 2019 Proinflammatory effects occur late and represent a modified ER stress response, mediated by IRE1a (inositol-requiring enzyme 1a)/ASK1 (apoptosis signal-regulating kinase 1)/p38 MAPK (p38 mitogen-activated protein kinase) signaling, that occurs under conditions of extreme cholesterol depletion. Inositol 99-107 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 92-97 31783679-7 2019 In addition, sperm in the myoinositol-supplemented group showed a significantly lower expression of pro-apoptotic (BAX) and mitochondrial reactive oxygen species (ROS) modulator (ROMO1) genes but higher expression of anti-apoptotic (BCL2), and protamine-related (PRM2 and PRM3) genes compared with that in the control group. Inositol 26-37 BCL2 associated X, apoptosis regulator Canis lupus familiaris 115-118 31783679-7 2019 In addition, sperm in the myoinositol-supplemented group showed a significantly lower expression of pro-apoptotic (BAX) and mitochondrial reactive oxygen species (ROS) modulator (ROMO1) genes but higher expression of anti-apoptotic (BCL2), and protamine-related (PRM2 and PRM3) genes compared with that in the control group. Inositol 26-37 reactive oxygen species modulator 1 Canis lupus familiaris 179-184 31783679-7 2019 In addition, sperm in the myoinositol-supplemented group showed a significantly lower expression of pro-apoptotic (BAX) and mitochondrial reactive oxygen species (ROS) modulator (ROMO1) genes but higher expression of anti-apoptotic (BCL2), and protamine-related (PRM2 and PRM3) genes compared with that in the control group. Inositol 26-37 BCL2 apoptosis regulator Canis lupus familiaris 233-237 31783679-7 2019 In addition, sperm in the myoinositol-supplemented group showed a significantly lower expression of pro-apoptotic (BAX) and mitochondrial reactive oxygen species (ROS) modulator (ROMO1) genes but higher expression of anti-apoptotic (BCL2), and protamine-related (PRM2 and PRM3) genes compared with that in the control group. Inositol 26-37 protamine-2 Canis lupus familiaris 263-267 31783679-7 2019 In addition, sperm in the myoinositol-supplemented group showed a significantly lower expression of pro-apoptotic (BAX) and mitochondrial reactive oxygen species (ROS) modulator (ROMO1) genes but higher expression of anti-apoptotic (BCL2), and protamine-related (PRM2 and PRM3) genes compared with that in the control group. Inositol 26-37 protamine-3 Canis lupus familiaris 272-276 31771123-6 2019 Moreover, LMPTP inhibition increased alternative splicing of X-box binding protein 1 (XBP1), suggesting high endonuclease activity of inositol-requiring enzyme 1 alpha (IRE1alpha). Inositol 134-142 LOW QUALITY PROTEIN: X-box-binding protein 1 Equus caballus 61-84 31771123-6 2019 Moreover, LMPTP inhibition increased alternative splicing of X-box binding protein 1 (XBP1), suggesting high endonuclease activity of inositol-requiring enzyme 1 alpha (IRE1alpha). Inositol 134-142 LOW QUALITY PROTEIN: X-box-binding protein 1 Equus caballus 86-90 31349070-7 2019 In addition, lower NAA, Glx, and mI levels in the SM1 were found to be correlates of poorer dexterous performance on a bimanual dexterity task. Inositol 33-35 SM1 Homo sapiens 50-53 31398432-9 2019 The difference in ADC was found to be statistically significant for the creatines, cholines, N-acetylaspartate, myo-inositol, and glutamate. Inositol 112-124 antizyme inhibitor 2 Homo sapiens 18-21 31698846-1 2019 Inositol-requiring enzyme 1alpha (IRE1alpha) is a transmembrane dual kinase/ribonuclease protein involved in propagation of the unfolded protein response (UPR). Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 34-43 31408662-10 2019 In addition, exogenous administration of IMD significantly attenuated PDGF-BB-induced cell proliferation and GRP78, phosphorylase-inositol requiring enzyme 1alpha, ATF4, and ATF6 protein levels. Inositol 130-138 adrenomedullin 2 Mus musculus 41-44 31605028-7 2019 Myo-inositol treatment ameliorated the decreased expression of ZO-1 and synaptopodin in an in vitro FSGS model, and as myo-inositol increased, myo-inositol oxygenase tissue expression decreased proportionally to eGFR. Inositol 0-12 tight junction protein 1 Homo sapiens 63-67 30993683-2 2019 Inositols, which act as insulin sensitizers, have the potential to alter folliculogenesis and the functional ovarian reserve, with subsequent benefits to reproductive outcomes following IVF/ICSI treatment. Inositol 0-9 insulin Homo sapiens 24-31 31734653-1 2019 OBJECTIVE: The aim of the present study was to examine the effect of glucose deprivation on the expression of genes encoded glucocorticoid receptor (NR3C1) and some related proteins (NR3C2, AHR, NRIP1, NNT, ARHGAP35, SGK1, and SGK3) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1/inositol requiring enzyme 1) for evaluation of their possible significance in the control of glioma growth through endoplasmic reticulum stress signaling mediated by IRE1 and glucose deprivation. Inositol 389-397 nuclear receptor subfamily 3 group C member 1 Homo sapiens 124-147 31734653-1 2019 OBJECTIVE: The aim of the present study was to examine the effect of glucose deprivation on the expression of genes encoded glucocorticoid receptor (NR3C1) and some related proteins (NR3C2, AHR, NRIP1, NNT, ARHGAP35, SGK1, and SGK3) in U87 glioma cells in response to inhibition of endoplasmic reticulum stress signaling mediated by ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1/inositol requiring enzyme 1) for evaluation of their possible significance in the control of glioma growth through endoplasmic reticulum stress signaling mediated by IRE1 and glucose deprivation. Inositol 389-397 nuclear receptor subfamily 3 group C member 1 Homo sapiens 149-154 31325888-9 2019 Besides, the ER stress-related inositol-requiring enzyme 1alpha (IRE1alpha)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway could be activated by reactive oxygen species (ROS) to regulate autophagy. Inositol 31-39 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 65-74 31325888-9 2019 Besides, the ER stress-related inositol-requiring enzyme 1alpha (IRE1alpha)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway could be activated by reactive oxygen species (ROS) to regulate autophagy. Inositol 31-39 protein tyrosine kinase 2 beta Homo sapiens 76-92 31325888-9 2019 Besides, the ER stress-related inositol-requiring enzyme 1alpha (IRE1alpha)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway could be activated by reactive oxygen species (ROS) to regulate autophagy. Inositol 31-39 AKT serine/threonine kinase 1 Homo sapiens 94-97 31325888-9 2019 Besides, the ER stress-related inositol-requiring enzyme 1alpha (IRE1alpha)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway could be activated by reactive oxygen species (ROS) to regulate autophagy. Inositol 31-39 mechanistic target of rapamycin kinase Homo sapiens 99-128 31325888-9 2019 Besides, the ER stress-related inositol-requiring enzyme 1alpha (IRE1alpha)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) signaling pathway could be activated by reactive oxygen species (ROS) to regulate autophagy. Inositol 31-39 mechanistic target of rapamycin kinase Homo sapiens 130-134 31607947-3 2019 We investigated this issue and showed that inflammatory stimuli can induce the activation of the protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) and inositol-requiring enzyme 1alpha (IRE1alpha) arms of the UPR in myocytes both in vivo and in vitro. Inositol 165-173 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 199-208 31720147-1 2019 Inositol, an emerging novel therapy for the treatment of gestational diabetes mellitus (GDM), is a cyclic polyol that has insulin-like effects and plays an important role in glucose homeostasis. Inositol 0-8 insulin Homo sapiens 122-129 31720147-2 2019 The conventional treatment of GDM with insulin and oral antihyperglycemic drugs usually comes with side effects, paving the way for and shedding spotlight on clinical trials involving inositol. Inositol 184-192 insulin Homo sapiens 39-46 31692879-2 2019 We found that apoptotic signaling by inositol requiring enzyme 1alpha (IRE1alpha), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress. Inositol 37-45 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 71-80 31692879-2 2019 We found that apoptotic signaling by inositol requiring enzyme 1alpha (IRE1alpha), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress. Inositol 37-45 membrane associated ring-CH-type finger 5 Homo sapiens 153-158 31692879-2 2019 We found that apoptotic signaling by inositol requiring enzyme 1alpha (IRE1alpha), a transducer of UPRs, is suppressed by mitochondrial ubiquitin ligase MITOL/MARCH5 on ER-mitochondria contacts, suggesting that mitochondria regulate cell fate under ER stress. Inositol 37-45 membrane associated ring-CH-type finger 5 Homo sapiens 159-165 31294448-17 2019 The higher myo-inositol release from phytate could contribute to the increased expression of GLUT4 in muscle plasma membranes. Inositol 11-23 solute carrier family 2 member 4 Sus scrofa 93-98 31148259-3 2019 In the present research, we attempt to investigate whether molecules with anti-inflammatory activity, alpha-lipoic acid (ALA), and/or myoinositol affect the endometrial NALP-3 expression and activation. Inositol 134-145 NLR family pyrin domain containing 3 Homo sapiens 169-175 31041814-2 2019 The UPR is a conserved cellular survival mechanism mediated by the ER transmembrane proteins activating transcription factor 6, protein kinase-like endoplasmic reticulum kinase, and inositol-requiring enzyme 1alpha (IRE1alpha) that act to resolve ER stress and promote cell survival. Inositol 182-190 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 216-225 31315971-7 2019 RESULTS: Asymptomatic MAPT mutation carriers had lower neuronal marker N-acetylaspartate (NAA)/creatine (Cr) (p = 0.001) and lower NAA/myo-inositol (mI) (p = 0.026) than noncarriers after adjustment for age. Inositol 135-147 microtubule associated protein tau Homo sapiens 22-26 31315971-7 2019 RESULTS: Asymptomatic MAPT mutation carriers had lower neuronal marker N-acetylaspartate (NAA)/creatine (Cr) (p = 0.001) and lower NAA/myo-inositol (mI) (p = 0.026) than noncarriers after adjustment for age. Inositol 149-151 microtubule associated protein tau Homo sapiens 22-26 31315971-8 2019 Symptomatic MAPT mutation carriers had lower NAA/Cr (p = 0.01) and NAA/mI (p = 0.01) and higher mI/Cr (p = 0.02) compared to noncarriers after adjustment for age. Inositol 71-73 microtubule associated protein tau Homo sapiens 12-16 31315971-8 2019 Symptomatic MAPT mutation carriers had lower NAA/Cr (p = 0.01) and NAA/mI (p = 0.01) and higher mI/Cr (p = 0.02) compared to noncarriers after adjustment for age. Inositol 96-98 microtubule associated protein tau Homo sapiens 12-16 31385695-3 2019 The observed INS transitions were thus assigned to spin wave excitations in a bounded ferromagnetic spin cluster and moreover could be visualized in a straightforward way based on this theory. Inositol 13-16 spindlin 1 Homo sapiens 51-55 31385695-3 2019 The observed INS transitions were thus assigned to spin wave excitations in a bounded ferromagnetic spin cluster and moreover could be visualized in a straightforward way based on this theory. Inositol 13-16 spindlin 1 Homo sapiens 100-104 31426466-6 2019 In fact, a fructose-induced increase in the levels of pIRE1 (phosphorylated inositol requiring enzyme-1) and its downstream effector, X-box binding protein-1 spliced form (XBP1s), was observed. Inositol 76-84 X-box binding protein 1 Rattus norvegicus 134-157 31497350-6 2019 Here we show for the first time that MIs reduced menin protein levels and decreased the half-life of menin protein but have no effect on mRNA level in MLL-FP-expressing leukemia cells, and proteasome or E1 ligase inhibitor rescued the MI-induced menin degradation. Inositol 37-39 menin 1 Homo sapiens 49-54 31497350-6 2019 Here we show for the first time that MIs reduced menin protein levels and decreased the half-life of menin protein but have no effect on mRNA level in MLL-FP-expressing leukemia cells, and proteasome or E1 ligase inhibitor rescued the MI-induced menin degradation. Inositol 37-39 menin 1 Homo sapiens 101-106 31497350-6 2019 Here we show for the first time that MIs reduced menin protein levels and decreased the half-life of menin protein but have no effect on mRNA level in MLL-FP-expressing leukemia cells, and proteasome or E1 ligase inhibitor rescued the MI-induced menin degradation. Inositol 37-39 menin 1 Homo sapiens 101-106 31497350-7 2019 Notably, the MI-induced reduction of H3K4m3 and HOXA9 expression was rescued with a proteasome inhibitor that blocks MI-induced menin protein degradation. Inositol 13-15 homeobox A9 Homo sapiens 48-53 31497350-7 2019 Notably, the MI-induced reduction of H3K4m3 and HOXA9 expression was rescued with a proteasome inhibitor that blocks MI-induced menin protein degradation. Inositol 13-15 menin 1 Homo sapiens 128-133 31497350-7 2019 Notably, the MI-induced reduction of H3K4m3 and HOXA9 expression was rescued with a proteasome inhibitor that blocks MI-induced menin protein degradation. Inositol 117-119 homeobox A9 Homo sapiens 48-53 31497350-7 2019 Notably, the MI-induced reduction of H3K4m3 and HOXA9 expression was rescued with a proteasome inhibitor that blocks MI-induced menin protein degradation. Inositol 117-119 menin 1 Homo sapiens 128-133 30744354-3 2019 Inositol requiring enzyme 1alpha (IRE1alpha)-X-box protein 1 (XBP1) is the most conserved pathway involved in the UPR and is the main component that mediates IRE1alpha signalling to downstream ER-associated degradation (ERAD)- or UPR-related genes. Inositol 0-8 LOW QUALITY PROTEIN: X-box-binding protein 1 Equus caballus 62-66 31081266-4 2019 It is reported that the inositol-requiring enzyme 1alpha (IRE1alpha) and its downstream molecules play a central role in the endoplasmic reticulum (ER) stress-induced apoptosis pathway. Inositol 24-32 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 58-67 30879088-0 2019 Impaired GCR1 transcription resulted in defective inositol levels, vacuolar structure and autophagy in Saccharomyces cerevisiae. Inositol 50-58 transcription regulator GCR1 Saccharomyces cerevisiae S288C 9-13 30879088-1 2019 In yeast, the GCR1 transcription factor is involved in the regulation of glycolysis and its deletion exhibited growth defect, reduced inositol and phosphatidylinositol (PI) levels compared to WT cells. Inositol 134-142 transcription regulator GCR1 Saccharomyces cerevisiae S288C 14-18 31103795-10 2019 Recent elevated TRAP exposure (beta = 4.71; 95% CI 0.95, 8.45) and increased myo-inositol levels (beta = 2.98; 95% CI 0.43, 5.52) were also significantly associated with increased generalized anxiety symptoms with 12% of the total effect between TRAP and generalized anxiety symptoms being mediated by myo-inositol levels. Inositol 77-89 potassium calcium-activated channel subfamily M regulatory beta subunit 2 Homo sapiens 98-106 31051095-2 2019 The inositol-requiring 1alpha (IRE1alpha) is an ER stress sensor and component of the UPR. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 31-40 31121416-2 2019 Inositol-requiring enzyme 1 alpha (IRE1alpha), the most conserved endoplasmic reticulum (ER) stress sensor, has been implicated in the pathophysiology of liver injury. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 35-44 31329612-2 2019 Upon accumulation of the UPR-converted XBP1 mRNA splicing from an unspliced (u) XBP1 (inactive) isoform to the spliced (s) XBP1 (active) isoform, inositol-requiring enzyme 1 alpha (IRE1alpha) removes a 26-nucleotide intron from uXBP1 mRNA. Inositol 146-154 X-box binding protein 1 Homo sapiens 39-43 31029679-1 2019 Drosophila egg-derived tyrosine phosphatase (EDTP), a lipid phosphatase that removes 3-position phosphate at the inositol ring, has dual functions in oogenesis and muscle performance in adults. Inositol 113-121 Egg-derived tyrosine phosphatase Drosophila melanogaster 45-49 31283839-3 2019 A drop in inositol levels in infants with respiratory distress syndrome (RDS) can be a sign that their illness will be severe. Inositol 10-18 peripherin 2 Homo sapiens 73-76 31283839-4 2019 OBJECTIVES: To assess the effectiveness and safety of supplementary inositol in preterm infants with or without respiratory distress syndrome (RDS) in reducing adverse neonatal outcomes including: death (neonatal and infant deaths), bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular haemorrhage (IVH), periventricular leukomalacia (PVL), necrotizing enterocolitis (NEC) and sepsis. Inositol 68-76 peripherin 2 Homo sapiens 143-146 31285424-8 2019 Furthermore, CTRP3 regulated the expression of the p38/CREB pathway and of the primary modulating factors of the endoplasmic reticulum stress, i.e., GRP78 and the downstream molecules eukaryotic translation inhibition factor 2 submit alpha, C/EBP homologous protein, and inositol-requiring enzyme-1. Inositol 271-279 C1q and tumor necrosis factor related protein 3 Mus musculus 13-18 30889626-5 2019 However, in the last years, in a variety of experimental models, inositol and antioxidants supplementation have shown insulin-sensitizing, anti-inflammatory, and antioxidant properties, which could be mediated by some possible complementary mechanism of action. Inositol 65-73 insulin Homo sapiens 118-125 31293550-3 2019 Gas chromatography tandem mass spectrometry revealed that dimethyl disulfide (DMDS) and methyl isovalerate (MI) were two abundant compounds in the volatile profiles of N1-4. Inositol 108-110 sugar efflux transporter SWEET16 Glycine max 168-172 31281243-7 2019 In support of this hypothesis, a number of classic senescence-associated markers were found in remarkably elevated level in Irf3 -/- retina, including p53, p16INK4a, inositol-requiring enzyme 1alpha (IREalpha), p-H2A.X and promyelocytic leukemia protein (PML). Inositol 166-174 interferon regulatory factor 3 Mus musculus 124-128 31123148-6 2019 Liver-specific disruption of the inositol-requiring enzyme 1alpha (IRE1alpha)-XBP1s signaling branch results in diminished COPII vesicle trafficking. Inositol 33-41 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 67-76 31123148-6 2019 Liver-specific disruption of the inositol-requiring enzyme 1alpha (IRE1alpha)-XBP1s signaling branch results in diminished COPII vesicle trafficking. Inositol 33-41 X-box binding protein 1 Mus musculus 78-82 31163320-6 2019 Mechanistically, exosomes from microglial cells were incorporated into photoreceptors in vitro and inhibited the inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) cascade, which contributes to hypoxia-induced photoreceptor apoptosis. Inositol 113-121 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 147-156 31163320-6 2019 Mechanistically, exosomes from microglial cells were incorporated into photoreceptors in vitro and inhibited the inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) cascade, which contributes to hypoxia-induced photoreceptor apoptosis. Inositol 113-121 X-box binding protein 1 Mus musculus 158-181 31163320-6 2019 Mechanistically, exosomes from microglial cells were incorporated into photoreceptors in vitro and inhibited the inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) cascade, which contributes to hypoxia-induced photoreceptor apoptosis. Inositol 113-121 X-box binding protein 1 Mus musculus 183-187 31006881-7 2019 Myo-Inositol in the CNI free group (2.719 +- 0.549 institutional unit [iu]) was significantly lower compared to controls (3.181 +- 0.425 iu; P = 0.02), patients on low-dose (3.130 +- 0.513 iu; P < 0.05) and standard-dose CNI therapy (3.207 +- 0.632 iu; P < 0.02). Inositol 0-12 calcineurin binding protein 1 Homo sapiens 20-23 31006881-7 2019 Myo-Inositol in the CNI free group (2.719 +- 0.549 institutional unit [iu]) was significantly lower compared to controls (3.181 +- 0.425 iu; P = 0.02), patients on low-dose (3.130 +- 0.513 iu; P < 0.05) and standard-dose CNI therapy (3.207 +- 0.632 iu; P < 0.02). Inositol 0-12 calcineurin binding protein 1 Homo sapiens 221-224 31285958-6 2019 Activation of inositol-requiring enzyme 1alpha (IRE1alpha)-mRNA X-box binding protein 1 (XBP1) pathway and spliced XBP1 (XBP1s) expression were analyzed by Western blot, Phos-tag gel assay, RT-PCR, qRT-PCR and flow cytometry. Inositol 14-22 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 48-57 31285958-6 2019 Activation of inositol-requiring enzyme 1alpha (IRE1alpha)-mRNA X-box binding protein 1 (XBP1) pathway and spliced XBP1 (XBP1s) expression were analyzed by Western blot, Phos-tag gel assay, RT-PCR, qRT-PCR and flow cytometry. Inositol 14-22 X-box binding protein 1 Homo sapiens 64-87 29980312-10 2019 CONCLUSIONS: Inositol supplementation decreases blood glucose through an improvement in insulin sensitivity that is independent of weight. Inositol 13-21 insulin Homo sapiens 88-95 30885990-3 2019 We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived PC (BMPC) dysfunction through augmenting the activity of an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), resulting in improved diabetic wound healing. Inositol 195-203 glyoxalase 1 Mus musculus 39-51 30885990-3 2019 We hypothesized that the MGO scavenger glyoxalase 1 (GLO1) reverses bone marrow-derived PC (BMPC) dysfunction through augmenting the activity of an important endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), resulting in improved diabetic wound healing. Inositol 195-203 glyoxalase 1 Mus musculus 53-57 31298405-1 2019 OBJECTIVE: The aim of this clinical trial was to evaluate the efficacy of seven different ratios between two inositols stereoisomers, myo-inositol (MI) and D-chiro-inositol (DCI), in the therapy of polycystic ovary syndrome (PCOS). Inositol 156-172 enoyl-CoA delta isomerase 1 Homo sapiens 174-177 31298405-5 2019 RESULTS: We found that the 40:1 MI/DCI ratio is the best for PCOS therapy aimed at restoring ovulation and normalizing important parameters in these patients. Inositol 32-34 enoyl-CoA delta isomerase 1 Homo sapiens 35-38 31298405-8 2019 CONCLUSIONS: Our data demonstrated that DCI activity is beneficial mainly at a specific ratio with MI, whereas the increase of DCI causes the loss of the beneficial effects at reproductive level. Inositol 99-101 enoyl-CoA delta isomerase 1 Homo sapiens 40-43 30612488-11 2019 Insulin sensitivity improved in women with IR only, confirming that in presence of IR the d-chiro-inositol has a role in restoring the insulin action overcoming the inactivity of epimerase in transforming myo-inositol to d-chiro inositol. Inositol 90-106 insulin Homo sapiens 0-7 30612488-11 2019 Insulin sensitivity improved in women with IR only, confirming that in presence of IR the d-chiro-inositol has a role in restoring the insulin action overcoming the inactivity of epimerase in transforming myo-inositol to d-chiro inositol. Inositol 90-106 insulin Homo sapiens 135-142 30612488-11 2019 Insulin sensitivity improved in women with IR only, confirming that in presence of IR the d-chiro-inositol has a role in restoring the insulin action overcoming the inactivity of epimerase in transforming myo-inositol to d-chiro inositol. Inositol 205-217 insulin Homo sapiens 0-7 30612488-11 2019 Insulin sensitivity improved in women with IR only, confirming that in presence of IR the d-chiro-inositol has a role in restoring the insulin action overcoming the inactivity of epimerase in transforming myo-inositol to d-chiro inositol. Inositol 205-217 insulin Homo sapiens 135-142 30317628-5 2019 When mice were returned to a normal light-dark regimen for 10 days, a slight, spontaneous improvement occurred, whereas a quick and almost complete recovery from PCOS signs and symptoms was obtained by treating animals with a daily supplementation of 420 mg/kg myo-inositol and D-chiro-inositol (MyoIns/DCIns) in a 40:1 molar ratio. Inositol 278-294 synaptopodin 2 Mus musculus 261-264 30218400-7 2019 Using dopaminergic N27 neurons, primary neurons from wild type (WT), and GMF-deficient (GMF-KO) mice, we show that GMF and MPP+ enhanced expression of MAPKs increased the mammalian target of rapamycin (mTOR) activation and endoplasmic reticulum stress markers such as phospho-eukaryotic translation initiation factor 2 alpha kinase 3 (p-PERK) and inositol-requiring enzyme 1alpha (IRE1alpha). Inositol 347-355 mechanistic target of rapamycin kinase Homo sapiens 171-200 30790354-8 2019 Suppressing GFAT activity resulted in downregulation of BiP that activated inositol-requiring enzyme 1alpha, a sensor protein of UPR, and exacerbated cisplatin-induced cell apoptosis. Inositol 75-83 glutamine--fructose-6-phosphate transaminase 1 Homo sapiens 12-16 30790354-8 2019 Suppressing GFAT activity resulted in downregulation of BiP that activated inositol-requiring enzyme 1alpha, a sensor protein of UPR, and exacerbated cisplatin-induced cell apoptosis. Inositol 75-83 heat shock protein family A (Hsp70) member 5 Homo sapiens 56-59 31096655-8 2019 In contrast, myo-inositol, had significantly lower concentrations in leaf samples despite up regulation of INPS suggesting the transcriptionally regulated flux of carbon through the myo-inositol pool is important during water deficit. Inositol 13-25 myo-inositol-3-phosphate synthase Glycine max 107-111 31096655-8 2019 In contrast, myo-inositol, had significantly lower concentrations in leaf samples despite up regulation of INPS suggesting the transcriptionally regulated flux of carbon through the myo-inositol pool is important during water deficit. Inositol 182-194 myo-inositol-3-phosphate synthase Glycine max 107-111 31205564-2 2019 As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression. Inositol 88-96 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 122-131 31205564-2 2019 As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression. Inositol 88-96 X-box binding protein 1 Homo sapiens 133-156 31205564-2 2019 As the most conserved branch among the three un-folded protein response (UPR) pathways, Inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling has been implicated in cancer development and progression. Inositol 88-96 X-box binding protein 1 Homo sapiens 158-162 31171961-2 2019 Replacement of the alpha-glucopyranosyl unit of adenophostin A, a potent d-myo-inositol 1,4,5-trisphosphate (IP3R) agonist, with a d-chiro-inositol surrogate acting substantially as a pseudosugar, leads to "d-chiro-inositol adenophostin". Inositol 131-147 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 109-113 30608001-0 2019 Comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome: a randomized controlled clinical trial. Inositol 14-26 insulin Homo sapiens 109-116 30608001-1 2019 This investigation was conducted to evaluate comparison of myo-inositol and metformin on glycemic control, lipid profiles, and gene expression related to insulin and lipid metabolism in women with polycystic ovary syndrome (PCOS). Inositol 59-71 insulin Homo sapiens 154-161 30608001-5 2019 Moreover, myo-inositol supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (p=.002) compared with metformin. Inositol 10-22 peroxisome proliferator activated receptor gamma Homo sapiens 70-118 30608001-5 2019 Moreover, myo-inositol supplementation upregulated gene expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) (p=.002) compared with metformin. Inositol 10-22 peroxisome proliferator activated receptor gamma Homo sapiens 120-130 30608001-6 2019 Overall, taking myo-inositol, compared with metformin, for 12 weeks by women with PCOS had beneficial effects on glycemic control, triglycerides and VLDL-cholesterol levels, and gene expression of PPAR-gamma. Inositol 16-28 peroxisome proliferator activated receptor gamma Homo sapiens 197-207 30896816-1 2019 Four phospholipase C beta (PLCB) isoforms, PLCB1, PLCB2, PLCB3 and PLCB4, have been previously investigated regarding their roles in the metabolism of inositol lipids and cancer. Inositol 151-159 phospholipase C beta 1 Homo sapiens 43-48 30896816-1 2019 Four phospholipase C beta (PLCB) isoforms, PLCB1, PLCB2, PLCB3 and PLCB4, have been previously investigated regarding their roles in the metabolism of inositol lipids and cancer. Inositol 151-159 phospholipase C beta 2 Homo sapiens 50-55 30896816-1 2019 Four phospholipase C beta (PLCB) isoforms, PLCB1, PLCB2, PLCB3 and PLCB4, have been previously investigated regarding their roles in the metabolism of inositol lipids and cancer. Inositol 151-159 phospholipase C beta 3 Homo sapiens 57-62 30896816-1 2019 Four phospholipase C beta (PLCB) isoforms, PLCB1, PLCB2, PLCB3 and PLCB4, have been previously investigated regarding their roles in the metabolism of inositol lipids and cancer. Inositol 151-159 phospholipase C beta 4 Homo sapiens 67-72 31008487-11 2019 Over-expression of S100A16 up-regulated protein expression levels of HSPA5, inositol-requiring enzyme 1alpha (IRE1alpha) and pIREalpha1, which belong to endoplasmic reticulum stress HSPA5/IRE1alpha-XBP1 pathway. Inositol 76-84 S100 calcium binding protein A16 Homo sapiens 19-26 30965648-10 2019 Moreover, HBE1 overexpression was found to attenuate radiation-induced endoplasmic reticulum stress and apoptosis via an inositol-requiring enzyme 1(IRE1)-Jun amino-terminal kinase (JNK) signaling pathway. Inositol 121-129 hemoglobin subunit epsilon 1 Homo sapiens 10-14 30965648-10 2019 Moreover, HBE1 overexpression was found to attenuate radiation-induced endoplasmic reticulum stress and apoptosis via an inositol-requiring enzyme 1(IRE1)-Jun amino-terminal kinase (JNK) signaling pathway. Inositol 121-129 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 147-158 30965648-10 2019 Moreover, HBE1 overexpression was found to attenuate radiation-induced endoplasmic reticulum stress and apoptosis via an inositol-requiring enzyme 1(IRE1)-Jun amino-terminal kinase (JNK) signaling pathway. Inositol 121-129 mitogen-activated protein kinase 8 Homo sapiens 182-185 30943188-7 2019 Cultured murine Xbp1 deficient VSMCs migrated more in response to platelet derived growth factor (PDGF) than control VSMCs, and had an increased level of inositol-requiring enzyme 1alpha (Ire1alpha), a PDGF receptor-binding UPRER transmembrane endonuclease whose substrates include XBP1. Inositol 154-162 X-box binding protein 1 Mus musculus 16-20 30943188-7 2019 Cultured murine Xbp1 deficient VSMCs migrated more in response to platelet derived growth factor (PDGF) than control VSMCs, and had an increased level of inositol-requiring enzyme 1alpha (Ire1alpha), a PDGF receptor-binding UPRER transmembrane endonuclease whose substrates include XBP1. Inositol 154-162 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 188-197 30943411-1 2019 Activation of inositol-requiring enzyme (IRE1alpha) is an indispensable step in remedying the cellular stress associated with lipid perturbation in the endoplasmic reticulum (ER) membrane. Inositol 14-22 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 41-50 30682567-11 2019 The addition of a PIK3CD inhibitor blocked the induction of cell proliferation by myo-inositol in ATDC5 cells. Inositol 82-94 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Mus musculus 18-24 30682567-13 2019 The specific promotion of mandibular growth by myoinositol is primarily dependent on the specific intensive expression of PIK3CD in the MCC. Inositol 47-58 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Mus musculus 122-128 30719816-7 2019 Further analysis to understand the molecular mechanism of action showed that the effect of KFL is mediated by the activation of the endoribonuclease activity of inositol-requiring enzyme 1 alpha (IRE1alpha), an endoplasmic reticulum-resident transmembrane protein. Inositol 161-169 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 196-205 30472165-4 2019 ER stress characterises by the activation of the unfolded protein response via three canonical ER stress sensors, i.e., the protein kinase RNA-like endoplasmic reticulum kinase (PERK), inositol-requiring enzyme 1alpha (IRE1alpha), and activating transcription factor 6. Inositol 185-193 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 219-228 30802722-0 2019 Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-beta and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. Inositol 15-27 MLX interacting protein-like Rattus norvegicus 54-101 30802722-0 2019 Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-beta and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. Inositol 15-27 MLX interacting protein-like Rattus norvegicus 109-115 30802722-0 2019 Treatment with myo-inositol attenuates binding of the carbohydrate-responsive element-binding protein to the ChREBP-beta and FASN genes in rat nonalcoholic fatty liver induced by high-fructose diet. Inositol 15-27 fatty acid synthase Rattus norvegicus 125-129 30802722-1 2019 Dietary supplementation with the major lipotrope myo-inositol (MI) potently reduces triglyceride (TG) content and expression levels of the fatty acid synthesis genes, for example, fatty acid synthase (FASN), in rat nonalcoholic fatty liver induced by high-fructose diet. Inositol 49-61 fatty acid synthase Rattus norvegicus 180-199 30802722-1 2019 Dietary supplementation with the major lipotrope myo-inositol (MI) potently reduces triglyceride (TG) content and expression levels of the fatty acid synthesis genes, for example, fatty acid synthase (FASN), in rat nonalcoholic fatty liver induced by high-fructose diet. Inositol 49-61 fatty acid synthase Rattus norvegicus 201-205 30904021-2 2019 Although the association inositols-glucomannan may represent a good therapeutic strategy in the treatment of PCOS women with insulin resistance, the effect of inositols on the metabolomic profile of these women has not been described yet. Inositol 25-34 insulin Homo sapiens 125-132 30779566-1 2019 A series of imidazo[1,2- b]pyridazin-8-amine kinase inhibitors were discovered to allosterically inhibit the endoribonuclease function of the dual kinase-endoribonuclease inositol-requiring enzyme 1alpha (IRE1alpha), a key component of the unfolded protein response in mammalian cells and a potential drug target in multiple human diseases. Inositol 171-179 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 205-214 32462103-6 2019 Finally, we employed molecular docking and bioinformatics to identify residues likely critical for recognition of myo-inositol by GLUT13 and urate by GLUT9. Inositol 114-126 solute carrier family 2 member 9 Homo sapiens 150-155 30604625-9 2019 Activation of IMPA1 in response to increased glucose 6-phosphate (G6P) is known to play a critical role in inositol synthesis and recycling. Inositol 107-115 inositol monophosphatase 1 Rattus norvegicus 14-19 30604625-11 2019 We conclude that the formation of the newly discovered RAGE-IMPA1 complex could be responsible for the stimulation of inositol pathways and activation of Akt signaling in PAH. Inositol 118-126 advanced glycosylation end product-specific receptor Rattus norvegicus 55-59 30604625-11 2019 We conclude that the formation of the newly discovered RAGE-IMPA1 complex could be responsible for the stimulation of inositol pathways and activation of Akt signaling in PAH. Inositol 118-126 inositol monophosphatase 1 Rattus norvegicus 60-65 30620686-8 2019 Gene array analysis prompted a detailed mechanistic study, which revealed that Pak2 regulation of protective ER function was via the IRE (inositol-requiring enzyme)-1/XBP (X-box-binding protein)-1-dependent pathway. Inositol 138-146 p21 (RAC1) activated kinase 2 Mus musculus 79-83 30620686-8 2019 Gene array analysis prompted a detailed mechanistic study, which revealed that Pak2 regulation of protective ER function was via the IRE (inositol-requiring enzyme)-1/XBP (X-box-binding protein)-1-dependent pathway. Inositol 138-146 activating transcription factor 2 Mus musculus 167-170 30620686-8 2019 Gene array analysis prompted a detailed mechanistic study, which revealed that Pak2 regulation of protective ER function was via the IRE (inositol-requiring enzyme)-1/XBP (X-box-binding protein)-1-dependent pathway. Inositol 138-146 X-box binding protein 1 Mus musculus 172-196 30660605-5 2019 In INS-1 cells, with NOD-like receptor family pyrin domain-containing 3 (NLRP3) inhibitor pretreatment, As2O3-induced activation of pyroptosis was decreased; with tumor necrosis factor-alpha (TNF-alpha) inhibitor pretreatment, As2O3-induced activation of NLRP3 inflammasome and pyroptosis were decreased; further, with the inositol-requiring enzyme 1 alpha (IRE1alpha) inhibitor, As2O3-induced induction of TNF-alpha was decreased. Inositol 323-331 NLR family, pyrin domain containing 3 Rattus norvegicus 73-78 30610118-4 2019 Here, we found that TGFbeta treatment of immortalized HSCs (i.e. LX-2 cells) induces phosphorylation of the UPR sensor inositol-requiring enzyme 1alpha (IRE1alpha) in a SMAD2/3-procollagen I-dependent manner. Inositol 119-127 transforming growth factor beta 1 Homo sapiens 20-27 30610118-4 2019 Here, we found that TGFbeta treatment of immortalized HSCs (i.e. LX-2 cells) induces phosphorylation of the UPR sensor inositol-requiring enzyme 1alpha (IRE1alpha) in a SMAD2/3-procollagen I-dependent manner. Inositol 119-127 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 153-162 30610118-4 2019 Here, we found that TGFbeta treatment of immortalized HSCs (i.e. LX-2 cells) induces phosphorylation of the UPR sensor inositol-requiring enzyme 1alpha (IRE1alpha) in a SMAD2/3-procollagen I-dependent manner. Inositol 119-127 SMAD family member 2 Homo sapiens 169-176 30813301-8 2019 The UPR pathways involve three different sensors (protein kinase RNA(PKR)-like ER kinase (PERK), inositol requiring enzyme1alpha (IRE1) and activating transcription factor 6 (ATF6)) residing on the ER membranes. Inositol 97-105 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 130-134 30789943-0 2019 Myoinositol CEST signal in animals with increased Iba-1 levels in response to an inflammatory challenge-Preliminary findings. Inositol 0-11 induction of brown adipocytes 1 Mus musculus 50-55 30791611-10 2019 IDH2 mutant gliomas have a higher level of 2-HG/tCho (total choline=phosphocholine+glycerylphosphorylcholine) (2.48 +- 1.01vs.0.72 +- 0.38, Pc < 0.001) and myo-Inositol/tCho (2.70 +- 0.90 vs. 1.46 +- 0.51, Pc = 0.011) compared to IDH1 mutation gliomas. Inositol 159-171 isocitrate dehydrogenase (NADP(+)) 2 Homo sapiens 0-4 30529145-5 2019 ANP reduced binding immunoglobulin protein (Bip) expression (UPR major controller) which under non-stress conditions keeps inactive the stress sensor proteins: protein kinase-like ER kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6). Inositol 198-206 natriuretic peptide A Rattus norvegicus 0-3 30529145-5 2019 ANP reduced binding immunoglobulin protein (Bip) expression (UPR major controller) which under non-stress conditions keeps inactive the stress sensor proteins: protein kinase-like ER kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6). Inositol 198-206 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 12-42 30529145-5 2019 ANP reduced binding immunoglobulin protein (Bip) expression (UPR major controller) which under non-stress conditions keeps inactive the stress sensor proteins: protein kinase-like ER kinase (PERK), inositol-requiring enzyme-1 (IRE1) and activating transcription factor 6 (ATF6). Inositol 198-206 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 44-47 30153452-8 2019 Four metabolites were replicated and significantly associated to eGFR in all 3 studies: d-threitol, myo-inositol, 4-deoxierythronic acid and galacturonic acid. Inositol 100-112 epidermal growth factor receptor Homo sapiens 65-69 30346710-0 2019 Preference for Glucose over Inositol Headgroup during Lysolipid Activation of G Protein-Coupled Receptor 55. Inositol 28-36 G protein-coupled receptor 55 Homo sapiens 78-107 30664618-7 2019 PGAP1 modifies GPI-anchors through inositol deacylation, allowing it to be recognized by Tmp21. Inositol 35-43 post-GPI attachment to proteins inositol deacylase 1 Homo sapiens 0-5 30664618-7 2019 PGAP1 modifies GPI-anchors through inositol deacylation, allowing it to be recognized by Tmp21. Inositol 35-43 glucose-6-phosphate isomerase Homo sapiens 15-18 30664618-7 2019 PGAP1 modifies GPI-anchors through inositol deacylation, allowing it to be recognized by Tmp21. Inositol 35-43 transmembrane p24 trafficking protein 10 Homo sapiens 89-94 30630412-1 2019 BACKGROUND: T cell activation induces ER stress and upregulates Inositol Requiring Enzyme 1 alpha (IRE1alpha), an activator of the unfolded protein response (UPR) pathway. Inositol 64-72 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 99-108 30765332-11 2019 Stimulation of murine intestinal crypts and HT29-methotrexate treated cell line cells with MDX induced inositol requiring protein 1beta via a p38 MAP kinase-dependent mechanism. Inositol 103-111 mitogen-activated protein kinase 14 Mus musculus 142-145 31250768-9 2019 MI alone or associated with Se at 0.2 or 0.4 mg/kg significantly reduced iNOS and TNF-alpha expression and MDA levels, increased GSH and testosterone levels, ameliorated structural organization and increased claudin-11 patches number. Inositol 0-2 nitric oxide synthase 2, inducible Mus musculus 73-77 31250768-9 2019 MI alone or associated with Se at 0.2 or 0.4 mg/kg significantly reduced iNOS and TNF-alpha expression and MDA levels, increased GSH and testosterone levels, ameliorated structural organization and increased claudin-11 patches number. Inositol 0-2 tumor necrosis factor Mus musculus 82-91 31250768-9 2019 MI alone or associated with Se at 0.2 or 0.4 mg/kg significantly reduced iNOS and TNF-alpha expression and MDA levels, increased GSH and testosterone levels, ameliorated structural organization and increased claudin-11 patches number. Inositol 0-2 claudin 11 Mus musculus 208-218 30020828-8 2019 Gene expression of proinflammatory cytokines IL-18 and IL-6 and phosphorylation of the endoplasmic reticulum stress marker inositol-requiring enzyme 1alpha were greater in FIT2 knockdown adipocytes than in control cells. Inositol 123-131 fat storage inducing transmembrane protein 2 Homo sapiens 172-176 31401629-6 2019 We studied the effect of INS on IL-25 release. Inositol 25-28 interleukin 25 Homo sapiens 32-37 29924303-9 2018 In addition, COI1 overexpression positively affects the availability of metabolites such as beta-alanine, threonic acid, putrescine, glucose and myo-inositol, thereby providing a connection between JA-inhibited growth and stress responses. Inositol 145-157 RNI-like superfamily protein Arabidopsis thaliana 13-17 30559399-2 2018 Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1alpha is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Inositol 58-66 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 92-101 30559399-2 2018 Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1alpha is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Inositol 58-66 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 238-247 30559399-2 2018 Here we show that an endoplasmic reticulum stress sensor, inositol-requiring enzyme 1alpha (IRE1alpha), links key cellular processes required for iNKT cell effector functions in specific iNKT subsets, in which TCR-dependent activation of IRE1alpha is associated with downstream activation of p38 MAPK and the stabilization of preformed cytokine mRNAs. Inositol 58-66 mitogen-activated protein kinase 14 Mus musculus 292-300 30574153-6 2018 B-I09, an inositol-requiring enzyme-1alpha (IRE1alpha) inhibitor that prevents XBP-1 splicing, reduces human moDC migration, allo-stimulatory potency, and curtails moDC IL-1beta, TGFbeta, and p40 cytokines, suppressing Th1 and Th17 cell priming. Inositol 10-18 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 44-53 30513929-5 2018 d-chiro-Inositol deficiency exacerbates insulin resistance in the liver, muscles, and fat, while depletion of myo-inositol results in the development of diabetic complications. Inositol 0-16 insulin Homo sapiens 40-47 30223017-6 2018 The results suggest that overexpression of RNF186 increases the protein levels of the ER stress sensors inositol requiring kinase 1 (IRE1) and C/EBP homologous protein (CHOP) protein, as well as the phosphorylation level of eukaryotic initiation factor 2alpha (eIF2alpha), in mouse primary hepatocytes. Inositol 104-112 ring finger protein 186 Mus musculus 43-49 29696609-5 2018 However, apocynin obviously attenuated EC apoptosis and this effect was partly dependent on ER stress sensor inositol-requiring enzyme 1alpha (IRE1alpha). Inositol 109-117 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 143-152 30514689-0 2018 [Combined treatment with myo-inositol and luteolin selectively suppresses growth of human lung cancer A549 cells possibly by suppressing activation of PDK1 and Akt]. Inositol 25-37 pyruvate dehydrogenase kinase 1 Homo sapiens 151-155 30514689-0 2018 [Combined treatment with myo-inositol and luteolin selectively suppresses growth of human lung cancer A549 cells possibly by suppressing activation of PDK1 and Akt]. Inositol 25-37 AKT serine/threonine kinase 1 Homo sapiens 160-163 30514689-8 2018 The expressions of p-PDK1 and p-Akt in myo-inositol-treated A549 cells and the expression of pPDK1 in luteolin-treated cells were significantly decreased (P &lt; 0.05), and the decrements were more obvious in the combined treatment group (P &lt; 0.05). Inositol 39-51 pyruvate dehydrogenase kinase 1 Homo sapiens 21-25 30514689-8 2018 The expressions of p-PDK1 and p-Akt in myo-inositol-treated A549 cells and the expression of pPDK1 in luteolin-treated cells were significantly decreased (P &lt; 0.05), and the decrements were more obvious in the combined treatment group (P &lt; 0.05). Inositol 39-51 AKT serine/threonine kinase 1 Homo sapiens 32-35 30514689-9 2018 CONCLUSIONS: Luteolin combined with myo-inositol can selectively inhibit the proliferation and migration of A549 cells, and these effects are probably mediated, at least in part, by suppressing the activation of PDK1 and Akt. Inositol 36-48 pyruvate dehydrogenase kinase 1 Homo sapiens 212-216 30514689-9 2018 CONCLUSIONS: Luteolin combined with myo-inositol can selectively inhibit the proliferation and migration of A549 cells, and these effects are probably mediated, at least in part, by suppressing the activation of PDK1 and Akt. Inositol 36-48 AKT serine/threonine kinase 1 Homo sapiens 221-224 30538632-3 2018 Previous researches reported that ER stress sensor inositol-requiring enzyme 1 alpha (IRE1alpha) was first activated in the process of liver fibrosis. Inositol 51-59 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 86-95 30595691-0 2018 Inositols in Insulin Signaling and Glucose Metabolism. Inositol 0-9 insulin Homo sapiens 13-20 30595691-3 2018 Moreover, intracellular glucose is required for de novo biosynthesis of inositol through the inositol-3-phosphate synthase 1 pathway, while a few glucose-related metabolites, like sorbitol, reduce intracellular levels of inositol. Inositol 72-80 inositol-3-phosphate synthase 1 Homo sapiens 93-124 30595691-4 2018 Furthermore, inositol, via its major isomers myo-inositol and D-chiro-inositol, and probably some of its phosphate intermediate metabolites and correlated enzymes (like inositol hexakisphosphate kinase) participate in both insulin signaling and glucose metabolism by influencing distinct pathways. Inositol 13-21 insulin Homo sapiens 223-230 30595691-4 2018 Furthermore, inositol, via its major isomers myo-inositol and D-chiro-inositol, and probably some of its phosphate intermediate metabolites and correlated enzymes (like inositol hexakisphosphate kinase) participate in both insulin signaling and glucose metabolism by influencing distinct pathways. Inositol 45-57 insulin Homo sapiens 223-230 30595691-4 2018 Furthermore, inositol, via its major isomers myo-inositol and D-chiro-inositol, and probably some of its phosphate intermediate metabolites and correlated enzymes (like inositol hexakisphosphate kinase) participate in both insulin signaling and glucose metabolism by influencing distinct pathways. Inositol 62-78 insulin Homo sapiens 223-230 30595691-5 2018 Indeed, clinical data support the beneficial effects exerted by inositol by reducing glycaemia levels and hyperinsulinemia and buffering negative effects of sustained insulin stimulation upon the adipose tissue and the endocrine system. Inositol 64-72 insulin Homo sapiens 111-118 30463294-9 2018 Compared with the doxorubicin group, the expression of cleaved activating transcription factor 6 and inositol-requiring enzyme 1 decreased in group ginsenoside Rg1. Inositol 101-109 protein phosphatase 1, regulatory subunit 3A Mus musculus 160-163 30505313-1 2018 The tonoplastic inositol transporter INT1 is the only known transport protein in Arabidopsis that facilitates myo-inositol import from the vacuole into the cytoplasm. Inositol 110-122 inositol transporter 1 Arabidopsis thaliana 37-41 30505313-2 2018 Impairment of the release of vacuolar inositol by knockout of INT1 results in a severe inhibition of cell elongation in roots as well as in etiolated hypocotyls. Inositol 38-46 inositol transporter 1 Arabidopsis thaliana 62-66 30505313-5 2018 Secondary effects as observed for altered availability of inositol in biosynthesis mutants, as disturbed membrane turnover, alterations in PIN protein localization or alterations in inositol-derived signaling molecules could be ruled out to be responsible for impairing the cell elongation in int1 mutants. Inositol 58-66 inositol transporter 1 Arabidopsis thaliana 293-297 30505313-6 2018 Although the molecular mechanism remains to be elucidated, our data implicate a crucial role of INT1-transported myo-inositol in regulating cell elongation in a sucrose-dependent manner and underline recent reports of regulatory roles for sucrose and other carbohydrate intermediates as metabolic semaphores. Inositol 113-125 inositol transporter 1 Arabidopsis thaliana 96-100 30420721-1 2018 Inositol polyphosphate multikinase (IPMK) is a member of the IPK-superfamily of kinases, catalyzing phosphorylation of several soluble inositols and the signaling phospholipid PI(4,5)P2 (PIP2). Inositol 135-144 inositol polyphosphate multikinase Homo sapiens 0-34 30420721-1 2018 Inositol polyphosphate multikinase (IPMK) is a member of the IPK-superfamily of kinases, catalyzing phosphorylation of several soluble inositols and the signaling phospholipid PI(4,5)P2 (PIP2). Inositol 135-144 inositol polyphosphate multikinase Homo sapiens 36-40 30282609-8 2018 Despite the overall similarity of the active site residues, scyllo-inositol is bound in an inverted, tilted orientation by sIDH relative to the orientation of myo-inositol by mIDH. Inositol 159-171 isocitrate dehydrogenase 1 (NADP+), soluble Mus musculus 175-179 30402159-8 2018 Further analysis suggested that IMB-6G treatment activated inositol-requiring enzyme 1alpha (IRE1alpha) and PKR-like ER kinase (PERK) signaling pathways in C666-1 cells. Inositol 59-67 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 93-102 30270194-1 2018 Myo-inositol (MI) and D-chiro-inositol (DCI) are insulin second messengers, and MI is involved in follicular gonadotropin pathways which orchestrate ovulation. Inositol 0-12 insulin Homo sapiens 49-56 30270194-1 2018 Myo-inositol (MI) and D-chiro-inositol (DCI) are insulin second messengers, and MI is involved in follicular gonadotropin pathways which orchestrate ovulation. Inositol 22-38 insulin Homo sapiens 49-56 30185587-4 2018 Inositol-requiring enzyme 1 alpha (IRE1alpha), a highly conserved ER stress sensor with both kinase and RNase activities, is involved in the IFN response. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 35-44 30185587-4 2018 Inositol-requiring enzyme 1 alpha (IRE1alpha), a highly conserved ER stress sensor with both kinase and RNase activities, is involved in the IFN response. Inositol 0-8 interferon alpha 1 Homo sapiens 141-144 30047091-9 2018 In MCF-7 cells, we found that IGF-1-induced growth, as well as phosphorylation of AktS473, mTOR and the tumor suppressor pRB, was inhibited in the presence of Inositol-C2-PAF. Inositol 159-167 insulin like growth factor 1 Homo sapiens 30-35 30047091-9 2018 In MCF-7 cells, we found that IGF-1-induced growth, as well as phosphorylation of AktS473, mTOR and the tumor suppressor pRB, was inhibited in the presence of Inositol-C2-PAF. Inositol 159-167 mechanistic target of rapamycin kinase Homo sapiens 91-95 30047091-9 2018 In MCF-7 cells, we found that IGF-1-induced growth, as well as phosphorylation of AktS473, mTOR and the tumor suppressor pRB, was inhibited in the presence of Inositol-C2-PAF. Inositol 159-167 RB transcriptional corepressor 1 Homo sapiens 121-124 30338829-1 2018 OBJECTIVE: Myo-inositol supplementation prevents gestational diabetes (GDM) in women at risk and reduces insulin resistance in women with GDM. Inositol 11-23 insulin Homo sapiens 105-112 30338829-4 2018 PATIENTS AND METHODS: Myo-inositol effect on glucose variability was studied in a pilot case-control study involving 12 consecutive pregnant women (median age 34 years, 25.0% insulin-treated) with GDM. Inositol 22-34 insulin Homo sapiens 175-182 30145684-5 2018 In this study, we demonstrate that exposure of insulin-secreting Min6 cells to a clinical dose of VPA results in inositol depletion and loss of co-localization of subunit C of vH+-ATPase with insulin-secreting granules. Inositol 113-121 insulin Homo sapiens 47-54 30106152-5 2018 In addition, the protein expression levels of inositol-requiring enzyme 1 (IRE1), X-box binding protein (XBP)-1 and glucose-regulated protein, 78 kDa (GRP78) in GH3 cells were detected by western blot analysis. Inositol 46-54 heat shock protein family A (Hsp70) member 5 Rattus norvegicus 151-156 30214606-1 2018 Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling is the most conserved. Inositol 102-110 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 136-145 30214606-1 2018 Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling is the most conserved. Inositol 102-110 X-box binding protein 1 Homo sapiens 147-170 30214606-1 2018 Of the three unfolded protein response pathways, which are activated by endoplasmic reticulum stress, inositol-requiring enzyme 1alpha (IRE1alpha)-X-box-binding protein 1 (XBP1) signaling is the most conserved. Inositol 102-110 X-box binding protein 1 Homo sapiens 172-176 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 X-box binding protein 1 Mus musculus 77-100 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 X-box binding protein 1 Mus musculus 102-106 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 161-170 30319453-3 2018 When the ER stress-induced unfolded protein response (UPR) is activated, the X-box binding protein 1 (XBP1) mRNA is spliced by inositol-requiring enzyme-1alpha (IRE1alpha) to produce the spliced form of XBP1 (sXBP1). Inositol 127-135 X-box binding protein 1 Mus musculus 203-207 30146262-1 2018 As the most conserved branch of the unfolded protein response (UPR), the inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protein entry into the endoplasmic reticulum (ER) and ER-associated degradation (ERAD). Inositol 73-81 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 103-108 30146262-1 2018 As the most conserved branch of the unfolded protein response (UPR), the inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protein entry into the endoplasmic reticulum (ER) and ER-associated degradation (ERAD). Inositol 73-81 X-box binding protein 1 Mus musculus 110-133 30146262-1 2018 As the most conserved branch of the unfolded protein response (UPR), the inositol-requiring enzyme 1a (IRE1a)/X-box binding protein 1 (XBP1) pathway plays crucial roles in cell survival and cell death by upregulating UPR-associated genes involved in protein entry into the endoplasmic reticulum (ER) and ER-associated degradation (ERAD). Inositol 73-81 X-box binding protein 1 Mus musculus 135-139 29859136-2 2018 Insulin sensitizing substances such as myo-inositol have been considered for the prevention of gestational diabetes mellitus and related complications. Inositol 39-51 insulin Homo sapiens 0-7 29574508-8 2018 Proximal proteins of ER stress inositol requiring enzyme 1 (IRE1), protein kinase like endoplasmic reticulum kinase (PERK), and activating transcription factor 6 (ATF6) were reduced in the beta-cells by SPL. Inositol 31-39 sphingosine-1-phosphate lyase 1 Rattus norvegicus 203-206 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Inositol 103-111 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 153-157 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Inositol 103-111 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 267-271 29430617-5 2018 In this study, treatment with tunicamycin, an ER stress inducer, enhanced the phosphorylation level of inositol-requiring ER-to-nucleus signal kinase 1 (IRE1) and increased X-box-binding protein 1 (XBP1) mRNA splicing activity in the mouse PFC, whereas inhibition of IRE1/XBP1 pathway in PFC by a viral particle approach attenuated social behavioral deficits caused by tunicamycin treatment. Inositol 103-111 X-box binding protein 1 Mus musculus 272-276 30080611-2 2018 In Arabidopsis thaliana and other plants, inositol-requiring enzyme-1 mediated unconventional splicing of bZIP60 plays a crucial role in the heat and ER stress responses. Inositol 42-50 basic region/leucine zipper motif 60 Arabidopsis thaliana 106-112 29991509-3 2018 The sole known inositol synthetic enzyme is myo-inositol synthase (MIPS), and the homolog in Drosophilia melanogaster is encoded by the Inos gene. Inositol 15-23 myo-inositol-1-phosphate synthase Drosophila melanogaster 136-140 30135303-6 2018 In vitro studies revealed that CHOP regulates hypoxia-induced apoptosis in AECs via the inositol-requiring enzyme 1alpha (IRE1alpha) and the PKR-like ER kinase (PERK) pathways. Inositol 88-96 DNA-damage inducible transcript 3 Mus musculus 31-35 30135303-6 2018 In vitro studies revealed that CHOP regulates hypoxia-induced apoptosis in AECs via the inositol-requiring enzyme 1alpha (IRE1alpha) and the PKR-like ER kinase (PERK) pathways. Inositol 88-96 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 122-131 30110882-6 2018 However, in yeast species, the only sensor present is the inositol-requiring enzyme Ire1. Inositol 58-66 bifunctional endoribonuclease/protein kinase IRE1 Saccharomyces cerevisiae S288C 84-88 30150984-4 2018 NOX2-independent mechanisms are realized by reagents affecting glutathione homeostasis (e.g., l-buthionine sulfoximine), modulators of the mitochondrial respiratory chain (e.g., ionophores, inositol mimics, and agonists of peroxisome proliferator-activated receptor gamma) and chemical ROS amplifiers [e.g., aminoferrocene-based prodrugs (ABPs)]. Inositol 190-198 cytochrome b-245 beta chain Homo sapiens 0-4 30159133-2 2018 The UPR signaling pathways initiated by double-stranded RNA-activated protein kinase (PKR) like ER kinase (PERK), inositol requiring enzyme 1 alpha (IRE1alpha), and activating transcription factor 6 (ATF6) are vital for tumor growth, aggressiveness, microenvironment remodeling, and resistance to cancer therapeutics. Inositol 114-122 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 149-158 29774465-2 2018 The aim of the study is to compare the effect of different dosages of inositol stereoisomers supplementation on insulin resistance levels and several maternal-fetal outcomes in GDM women. Inositol 70-78 insulin Homo sapiens 112-119 29774465-11 2018 CONCLUSIONS: Our study provides interesting but preliminary results about the potential role of inositol stereoisomers supplementation in the treatment of GDM on insulin resistance levels and several maternal-fetal outcomes. Inositol 96-104 insulin Homo sapiens 162-169 30112049-3 2018 Inositol-requiring enzyme 1 (IRE1), a member of the ER-localized transmembrane protein family, activates its downstream transcription factor X-box binding protein 1 (XBP1) to mediate a key part of the cellular unfolded protein response in order to cope with ER stress. Inositol 0-8 X-box binding protein 1 Rattus norvegicus 141-164 30112049-3 2018 Inositol-requiring enzyme 1 (IRE1), a member of the ER-localized transmembrane protein family, activates its downstream transcription factor X-box binding protein 1 (XBP1) to mediate a key part of the cellular unfolded protein response in order to cope with ER stress. Inositol 0-8 X-box binding protein 1 Rattus norvegicus 166-170 29457838-0 2018 Bax inhibitor-1 protects from nonalcoholic steatohepatitis by limiting inositol-requiring enzyme 1 alpha signaling in mice. Inositol 71-79 transmembrane BAX inhibitor motif containing 6 Mus musculus 0-15 29457838-2 2018 B-cell lymphoma 2 (BCL2)-associated X protein (Bax) inhibitor-1 (BI-1), a negative regulator of the ER stress sensor, inositol-requiring enzyme 1 alpha (IRE1alpha), has yet to be explored in NAFLD as a hepatoprotective agent. Inositol 118-126 B cell leukemia/lymphoma 2 Mus musculus 0-17 29457838-2 2018 B-cell lymphoma 2 (BCL2)-associated X protein (Bax) inhibitor-1 (BI-1), a negative regulator of the ER stress sensor, inositol-requiring enzyme 1 alpha (IRE1alpha), has yet to be explored in NAFLD as a hepatoprotective agent. Inositol 118-126 B cell leukemia/lymphoma 2 Mus musculus 19-23 29457838-2 2018 B-cell lymphoma 2 (BCL2)-associated X protein (Bax) inhibitor-1 (BI-1), a negative regulator of the ER stress sensor, inositol-requiring enzyme 1 alpha (IRE1alpha), has yet to be explored in NAFLD as a hepatoprotective agent. Inositol 118-126 transmembrane BAX inhibitor motif containing 6 Mus musculus 36-63 29457838-2 2018 B-cell lymphoma 2 (BCL2)-associated X protein (Bax) inhibitor-1 (BI-1), a negative regulator of the ER stress sensor, inositol-requiring enzyme 1 alpha (IRE1alpha), has yet to be explored in NAFLD as a hepatoprotective agent. Inositol 118-126 transmembrane BAX inhibitor motif containing 6 Mus musculus 65-69 29457838-2 2018 B-cell lymphoma 2 (BCL2)-associated X protein (Bax) inhibitor-1 (BI-1), a negative regulator of the ER stress sensor, inositol-requiring enzyme 1 alpha (IRE1alpha), has yet to be explored in NAFLD as a hepatoprotective agent. Inositol 118-126 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 153-162 29506314-4 2018 Here we report a dual role for inositol-requiring enzyme 1alpha (IRE1alpha), the ER-localized UPR signal transducer, in obesity-promoted HCC development. Inositol 31-39 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 65-74 29912856-5 2018 RESULTS: Inositol-requiring 1alpha (IRE1alpha)-mediated Jun N-terminal kinase (JNK)/nuclear factor-kappa B (NF-kappaB) pathway were activated early in AR42J cells and rat AP models. Inositol 9-17 mitogen-activated protein kinase 8 Rattus norvegicus 79-82 29377207-2 2018 The inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the unfolded protein response (UPR) is a protective cellular signaling pathway activated in response to endoplasmic reticulum (ER) stress. Inositol 4-12 X-box binding protein 1 Mus musculus 37-60 29377207-2 2018 The inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the unfolded protein response (UPR) is a protective cellular signaling pathway activated in response to endoplasmic reticulum (ER) stress. Inositol 4-12 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 62-71 29377207-2 2018 The inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the unfolded protein response (UPR) is a protective cellular signaling pathway activated in response to endoplasmic reticulum (ER) stress. Inositol 4-12 X-box binding protein 1 Mus musculus 72-76 29721770-7 2018 SelS knockdown also exacerbated LPS-induced increases of proinflammatory cytokines TNF-alpha and interleukin-6 expression, as well as increases of endoplasmic reticulum (ER) stress markers glucose-regulated protein 78 and inositol-requiring enzyme 1alpha expression in calcifying VSMCs. Inositol 222-230 selenoprotein S Homo sapiens 0-4 29673059-8 2018 Mechanistic investigations demonstrate that inositol-requiring enzyme 1alpha (IRE1alpha), one of three major signal transduction pathways activated during endoplasmic reticulum (ER) stress, is the downstream target of palmitate-elicited TLR4 activation and mechanistically implicated in TLR4 activation-triggered cell death in response to palmitate exposure. Inositol 44-52 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 78-87 29673059-8 2018 Mechanistic investigations demonstrate that inositol-requiring enzyme 1alpha (IRE1alpha), one of three major signal transduction pathways activated during endoplasmic reticulum (ER) stress, is the downstream target of palmitate-elicited TLR4 activation and mechanistically implicated in TLR4 activation-triggered cell death in response to palmitate exposure. Inositol 44-52 toll-like receptor 4 Mus musculus 237-241 29673059-8 2018 Mechanistic investigations demonstrate that inositol-requiring enzyme 1alpha (IRE1alpha), one of three major signal transduction pathways activated during endoplasmic reticulum (ER) stress, is the downstream target of palmitate-elicited TLR4 activation and mechanistically implicated in TLR4 activation-triggered cell death in response to palmitate exposure. Inositol 44-52 toll-like receptor 4 Mus musculus 287-291 29804923-5 2018 We focus here on inositol-requiring enzyme 1alpha (IRE1) and compile novel molecular mechanisms demonstrating that tumoral UPR controls the tumor microenvironment (TME) and the immune response, therefore opening potential novel therapeutic avenues. Inositol 17-25 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 51-55 29988564-6 2018 Mitochondrial Ca2+ uptake required functional inositol IP3R and RyR1 channels. Inositol 46-54 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 55-59 29933620-12 2018 Moreover, SH-EAE strikingly suppressed the protein expression of two ER stress sensors, including inositol requiring enzyme-1alpha (IRE-1alpha) and protein kinase R-like ER kinase (PERK), and antagonized the induction of C/EBP homologous protein (CHOP) expression by thapsigargin, an ER stress inducer. Inositol 98-106 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 132-142 29859544-1 2018 This review attempts to explain why consuming extra myoinositol (Ins), an essential component of membrane phospholipids, is often beneficial for patients with conditions characterised by insulin resistance, non-alcoholic fatty liver disease and endoplasmic reticulum (ER) stress. Inositol 52-63 insulin Homo sapiens 187-194 29859544-3 2018 Proposed explanations often suggest functional enhancement of minor facets of Ins Biology such as insulin signalling through putative inositol-containing "mediators", but offer no explanation for this selectivity. Inositol 134-142 insulin Homo sapiens 98-105 29747876-1 2018 IRE1alpha (Inositol Requiring kinase Enzyme 1 alpha), a transmembrane protein localized to the endoplasmic reticulum (ER) is a master regulator of the unfolded protein response (UPR) pathway. Inositol 11-19 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 0-9 29265900-3 2018 Insulin-sensitizing agents are used in the treatment of PCOS: in fact, inositols were shown to have insulin-mimetic properties. Inositol 71-80 insulin Homo sapiens 0-7 29265900-3 2018 Insulin-sensitizing agents are used in the treatment of PCOS: in fact, inositols were shown to have insulin-mimetic properties. Inositol 71-80 insulin Homo sapiens 100-107 29265900-12 2018 In conclusion, we can state that a good option for the treatment of PCOS is the combined administration of myo-inositol + gymnemic acid + l-methyl-folate, especially for overweight/obese patients with marked insulin resistance and with associated hyperhomocysteinemia. Inositol 107-119 insulin Homo sapiens 208-215 29901626-14 2018 Moreover, curcumin significantly increased inositol-requiring enzyme 1alpha (IRE1alpha) phosphorylation and XBP-1 mRNA splicing to induce a subsets of ER chaperones. Inositol 43-51 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 77-86 29777485-0 2018 Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis. Inositol 91-103 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 53-58 29777485-0 2018 Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis. Inositol 91-103 myo-inositol-1-phosphate synthase 2 Arabidopsis thaliana 60-65 29777485-0 2018 Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis. Inositol 91-103 myo-inositol-1-phosphate synthase 3 Arabidopsis thaliana 70-75 29534223-2 2018 Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein 1 (XBP-1) signalling pathway of the unfolded protein response, which then regulates genes involved in biogenesis of the secretory machinery. Inositol 68-76 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 102-111 29534223-2 2018 Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein 1 (XBP-1) signalling pathway of the unfolded protein response, which then regulates genes involved in biogenesis of the secretory machinery. Inositol 68-76 X-box binding protein 1 Homo sapiens 113-136 29534223-2 2018 Glandular dysfunction could be partly the consequence of an altered inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein 1 (XBP-1) signalling pathway of the unfolded protein response, which then regulates genes involved in biogenesis of the secretory machinery. Inositol 68-76 X-box binding protein 1 Homo sapiens 138-143 29793496-8 2018 Pooled results showed that inositol supplementation among patients with metabolic diseases significantly decreased triglycerides (SMD - 1.24; 95% CI, - 1.84, - 0.64; P < 0.001), total- (SMD - 1.09; 95% CI, - 1.83, - 0.55; P < 0.001), and LDL-cholesterol levels (SMD - 1.31; 95% CI, - 2.23, - 0.39; P = 0.005). Inositol 27-35 small nuclear ribonucleoprotein D1 polypeptide Homo sapiens 130-137 29793496-8 2018 Pooled results showed that inositol supplementation among patients with metabolic diseases significantly decreased triglycerides (SMD - 1.24; 95% CI, - 1.84, - 0.64; P < 0.001), total- (SMD - 1.09; 95% CI, - 1.83, - 0.55; P < 0.001), and LDL-cholesterol levels (SMD - 1.31; 95% CI, - 2.23, - 0.39; P = 0.005). Inositol 27-35 small nuclear ribonucleoprotein D1 polypeptide Homo sapiens 189-196 29793496-8 2018 Pooled results showed that inositol supplementation among patients with metabolic diseases significantly decreased triglycerides (SMD - 1.24; 95% CI, - 1.84, - 0.64; P < 0.001), total- (SMD - 1.09; 95% CI, - 1.83, - 0.55; P < 0.001), and LDL-cholesterol levels (SMD - 1.31; 95% CI, - 2.23, - 0.39; P = 0.005). Inositol 27-35 small nuclear ribonucleoprotein D1 polypeptide Homo sapiens 189-196 30027060-3 2018 A metabolomics analysis of cells exposed to nanosilver (nAg) integrates volcano plots (t-tests and fold change analysis), partial least squares-discriminant analysis (PLS-DA), and significance analysis of microarrays (SAM) and identifies six metabolites (l-aspartic acid, l-malic acid, myoinositol, d-sorbitol, citric acid, and l-cysteine). Inositol 286-297 NBAS subunit of NRZ tethering complex Homo sapiens 56-59 29764990-1 2018 Obesity or a high-fat diet represses the endoribonuclease activity of inositol-requiring enzyme 1alpha (IRE1alpha), a transducer of the unfolded protein response (UPR) in cells under endoplasmic reticulum (ER) stress. Inositol 70-78 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 104-113 29867401-8 2018 At age 9 lower CD4/CD8 at enrollment was associated with lower myo-inositol. Inositol 63-75 CD4 molecule Homo sapiens 15-18 29867401-8 2018 At age 9 lower CD4/CD8 at enrollment was associated with lower myo-inositol. Inositol 63-75 CD8a molecule Homo sapiens 19-22 29594285-9 2018 Impressively, we find that the inositol-requiring enzyme 1alpha (IRE1alpha)/nuclear factor-kappa B (NF-kappaB) pathway is significantly activated and contributes to the progress of LPS-induced HUVEC injury by promoting inflammatory cytokine production. Inositol 31-39 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 65-74 29594285-9 2018 Impressively, we find that the inositol-requiring enzyme 1alpha (IRE1alpha)/nuclear factor-kappa B (NF-kappaB) pathway is significantly activated and contributes to the progress of LPS-induced HUVEC injury by promoting inflammatory cytokine production. Inositol 31-39 nuclear factor kappa B subunit 1 Homo sapiens 100-109 29732320-3 2018 We previously demonstrated that the activity of host unfolded protein response (UPR) sensor IRE1alpha (inositol-requiring enzyme 1) and ER-associated autophagy confer susceptibility to Brucella melitensis and Brucella abortus intracellular replication. Inositol 103-111 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 92-101 29692785-6 2018 OPTN directly interacts with and promotes the removal of inositol-requiring enzyme 1alpha, a central inflammatory signaling hub of the stressed endoplasmic reticulum (ER). Inositol 57-65 optineurin Homo sapiens 0-4 29381485-2 2018 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol 96-104 MYC proto-oncogene, bHLH transcription factor Homo sapiens 19-22 29381485-2 2018 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol 96-104 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 130-139 29381485-2 2018 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol 96-104 X-box binding protein 1 Homo sapiens 141-164 29381485-2 2018 Here, we show that Myc overexpression induces endoplasmic reticulum (ER) stress and engages the inositol-requiring enzyme 1alpha (IRE1alpha)/X-box binding protein 1 (XBP1) pathway through multiple molecular mechanisms in a variety of c-Myc- and N-Myc-dependent cancers. Inositol 96-104 X-box binding protein 1 Homo sapiens 166-170 29518282-7 2018 RESULTS: Abeta + regions had significantly higher (p = 0.02) mI/Cr and lower tNA/Cr (p = 0.02), whereas in hypometabolic areas only tNA/Cr was reduced (p = 0.003). Inositol 61-63 amyloid beta precursor protein Homo sapiens 9-14 29518282-11 2018 INTERPRETATION: mI/Cr has significant temporal and spatial associations with Abeta and could potentially be considered as a disease state biomarker. Inositol 16-18 amyloid beta precursor protein Homo sapiens 77-82 29687835-0 2018 Use of alpha-lactalbumin for the management of PCOS in inositols resistant women. Inositol 55-64 lactalbumin alpha Homo sapiens 7-24 29357302-0 2018 Role of the inositol pyrophosphate multikinase Kcs1 in Cryptococcus inositol metabolism. Inositol 12-20 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 47-51 29357302-4 2018 In this study, we found that inositol, irrespective of the presence of glucose in the media, represses the expression of C. neoformans genes involved in inositol pyrophosphate biosynthesis, including the gene encoding inositol hexakisphosphate kinase Kcs1. Inositol 29-37 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 251-255 29357302-5 2018 Kcs1 was recently reported to regulate inositol metabolism in Saccharomyces cerevisiae and to impact virulence in C. neoformans. Inositol 39-47 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 0-4 29357302-7 2018 We found that Kcs1 negatively regulates inositol uptake and catabolism in C. neoformans, but, in contrast to Kcs1 function in S. cerevisiae, does not appear to regulate inositol biosynthesis. Inositol 40-48 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 14-18 29357302-8 2018 Together, these results show that Kcs1 functions to fine-tune inositol acquisition to maintain inositol homeostasis in C. neoformans. Inositol 62-70 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 34-38 29357302-8 2018 Together, these results show that Kcs1 functions to fine-tune inositol acquisition to maintain inositol homeostasis in C. neoformans. Inositol 95-103 inositol polyphosphate kinase KCS1 Saccharomyces cerevisiae S288C 34-38 29134640-0 2018 Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. Inositol 154-166 interleukin 6 Mus musculus 8-12 29134640-0 2018 Reduced IL-6 levels and tumor-associated phospho-STAT3 are associated with reduced tumor development in a mouse model of lung cancer chemoprevention with myo-inositol. Inositol 154-166 signal transducer and activator of transcription 3 Mus musculus 49-54 29134640-6 2018 myo-inositol has previously been reported to inhibit phosphoinositide 3-kinase (PI3K) signaling. Inositol 0-12 phosphoinositide-3-kinase regulatory subunit 1 Mus musculus 53-78 31938306-0 2018 Inositol phosphatase INPP4A inhibits the apoptosis of in vitro neurons with characteristic of intractable epilepsy by reducing intracellular Ca2+ concentration. Inositol 0-8 inositol polyphosphate-4-phosphatase type I A Homo sapiens 21-27 29444320-14 2018 The influence of phytase on phytate, phytate esters, and inositol may influence intestinal alkaline phosphatase activity and the gene expression of myo-inositol transporters in the small intestine. Inositol 57-65 alkaline phosphatase, intestinal Homo sapiens 80-111 29663989-10 2018 RESULTS: (1) Compared with the control group, the pathological changes of liver injury, the levels of AST and ALT in serum and protein expression of HMGB1 as well as ERS-related proteins such as glucose regulated protein 78 (GRP78), caspase-12, and inositol-requiring enzyme 1alpha (IRE1alpha) in liver tissue were significantly increased after traumatic stress, and reached the peak at 18 hours. Inositol 249-257 glutamic-oxaloacetic transaminase 2 Rattus norvegicus 102-105 29037103-1 2018 Polycystic ovary syndrome (PCOS)is a gynecological endocrine disorder which is associated with systemic inflammatory status inducing red blood cells (RBC) membrane alterations related to insulin resistance and testosterone levels which could be greatly improved by myo-inositol (MYO) uptake. Inositol 265-277 insulin Homo sapiens 187-194 29310864-5 2018 Abeta (beta = 0.45, p = 0.018) and white matter hyperintensities (beta = 0.40, p = 0.046) were independently and interactively (beta = -0.49, p = 0.026) associated with a higher ratio of mI over NAA (mI/NAA) in the posterior cingulate and precuneus gray matter but not in the white matter. Inositol 187-189 amyloid beta precursor protein Homo sapiens 0-5 29310864-5 2018 Abeta (beta = 0.45, p = 0.018) and white matter hyperintensities (beta = 0.40, p = 0.046) were independently and interactively (beta = -0.49, p = 0.026) associated with a higher ratio of mI over NAA (mI/NAA) in the posterior cingulate and precuneus gray matter but not in the white matter. Inositol 200-202 amyloid beta precursor protein Homo sapiens 0-5 29495516-7 2018 In addition, an increased expression of the glucose transporter-2 (GLUT2) gene was observed in the jejunum (P = 0.003) of inositol-supplemented rats when compared to sucrose supplementation. Inositol 122-130 solute carrier family 2 member 2 Rattus norvegicus 44-65 29495516-7 2018 In addition, an increased expression of the glucose transporter-2 (GLUT2) gene was observed in the jejunum (P = 0.003) of inositol-supplemented rats when compared to sucrose supplementation. Inositol 122-130 solute carrier family 2 member 2 Rattus norvegicus 67-72 29504610-6 2018 Furthermore, inositol-requiring enzyme-1alpha (IRE1alpha)-dependent degradation (RIDD) of IRE1alpha was reduced by IC87114, resulting in a decreased release of proinflammatory cytokines from bronchial epithelial cells. Inositol 13-21 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 47-56 29504610-6 2018 Furthermore, inositol-requiring enzyme-1alpha (IRE1alpha)-dependent degradation (RIDD) of IRE1alpha was reduced by IC87114, resulting in a decreased release of proinflammatory cytokines from bronchial epithelial cells. Inositol 13-21 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 90-99 29416111-3 2018 Under ER stress, activated inositol-requiring kinase 1alpha (IRE1alpha) unregulated CHOP, phosphorylated JNK and Caspase-12 to aggravate apoptosis-mediated damage of DPN. Inositol 27-35 DNA-damage inducible transcript 3 Rattus norvegicus 84-88 29416111-3 2018 Under ER stress, activated inositol-requiring kinase 1alpha (IRE1alpha) unregulated CHOP, phosphorylated JNK and Caspase-12 to aggravate apoptosis-mediated damage of DPN. Inositol 27-35 mitogen-activated protein kinase 8 Rattus norvegicus 105-108 29416111-3 2018 Under ER stress, activated inositol-requiring kinase 1alpha (IRE1alpha) unregulated CHOP, phosphorylated JNK and Caspase-12 to aggravate apoptosis-mediated damage of DPN. Inositol 27-35 caspase 12 Rattus norvegicus 113-123 29255114-6 2018 Calnexin was specifically associated with GPI-APs, dependent on N-glycan and GPI moieties, and assisted efficient GPI-inositol deacylation by PGAP1. Inositol 118-126 calnexin Homo sapiens 0-8 29255114-6 2018 Calnexin was specifically associated with GPI-APs, dependent on N-glycan and GPI moieties, and assisted efficient GPI-inositol deacylation by PGAP1. Inositol 118-126 post-GPI attachment to proteins inositol deacylase 1 Homo sapiens 142-147 28544572-9 2018 Inositol was associated with significantly improved ovulation rate (RR 2.3; 95% CI 1.1-4.7; I2 = 75%) and increased frequency of menstrual cycles (RR 6.8; 95% CI 2.8-16.6; I2 = 0%) compared with placebo. Inositol 0-8 ribonucleotide reductase regulatory subunit M2 Homo sapiens 68-72 28970254-4 2018 Phosphorylation of inositol-requiring enzyme (IRE)1alpha and eIF2alpha, expression of thioredoxin-interacting protein and cleaved caspase-1, and release of IL-1beta were reduced by silybin. Inositol 19-27 interleukin 1 beta Mus musculus 156-164 29594556-4 2018 The LODs are 1.0 mug L-1 for benzoic acid, 5.0 mug L-1 for MI and 0.5 mug L-1 for both BHA and BHT. Inositol 59-61 immunoglobulin kappa variable 1-16 Homo sapiens 51-54 29594556-4 2018 The LODs are 1.0 mug L-1 for benzoic acid, 5.0 mug L-1 for MI and 0.5 mug L-1 for both BHA and BHT. Inositol 59-61 immunoglobulin kappa variable 1-16 Homo sapiens 51-54 29157865-8 2018 Sarcoplasmic/endoplasmic reticulum Ca2+-ATPase pump (SERCA pump) inhibition partially prevent the PYY (3-36)-increase of [Ca2+]i and inositol 1,4,5-triphosphate receptor (IP3R) inhibition also decreased the PYY (3-36)-increase of [Ca2+]i. Inositol 133-141 peptide YY Homo sapiens 98-101 29185694-3 2018 PatA catalyzes the transfer of a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to the 2-position of inositol in PIM1/PIM2. Inositol 135-143 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 147-151 29185694-3 2018 PatA catalyzes the transfer of a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to the 2-position of inositol in PIM1/PIM2. Inositol 135-143 Pim-2 proto-oncogene, serine/threonine kinase Homo sapiens 152-156 28827025-6 2018 The regulation of the CHO1 expression is mediated through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. Inositol 62-70 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 22-26 28827025-6 2018 The regulation of the CHO1 expression is mediated through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. Inositol 62-70 Ino2p Saccharomyces cerevisiae S288C 181-185 28827025-6 2018 The regulation of the CHO1 expression is mediated through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. Inositol 62-70 Ino4p Saccharomyces cerevisiae S288C 186-190 28827025-6 2018 The regulation of the CHO1 expression is mediated through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. Inositol 62-70 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 191-195 30161013-4 2018 Human SGLT6 is an active transporter of myo-inositol and D-glucose. Inositol 40-52 solute carrier family 5 member 11 Homo sapiens 6-11 30357747-1 2018 Myo-inositol is a highly abundant stereoisomer of the inositol family of sugar alcohols and forms the structural basis for a variety of polyphosphate derivatives including second messengers and membrane phospholipids. Inositol 4-12 synaptopodin 2 Mus musculus 0-3 29940799-2 2018 Previously, we found that endoplasmic reticulum (ER) stress induces autophagy in plants via a pathway dependent upon AT5G24360/IRE1B (INOSITOL REQUIRING 1-1), an ER membrane-anchored factor involved in the splicing of AT1G42990/BZIP60 (basic leucine zipper protein 60) mRNA. Inositol 134-142 inositol requiring 1-1 Arabidopsis thaliana 127-132 29940799-2 2018 Previously, we found that endoplasmic reticulum (ER) stress induces autophagy in plants via a pathway dependent upon AT5G24360/IRE1B (INOSITOL REQUIRING 1-1), an ER membrane-anchored factor involved in the splicing of AT1G42990/BZIP60 (basic leucine zipper protein 60) mRNA. Inositol 134-142 basic region/leucine zipper motif 60 Arabidopsis thaliana 228-234 29208426-4 2018 5-AzaC caused a sustained activation of the inositol-requiring enzyme 1alpha (IRE1alpha) kinase domain and c-Jun N-terminal kinase (JNK) independently of endoplasmic reticulum stress. Inositol 44-52 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 78-87 30109813-1 2018 Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the sensor inositol-requiring enzyme 1alpha (IRE1), an endoribonuclease that splices the mRNA of the transcription factor XBP1 (X-box-binding protein 1). Inositol 88-96 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 122-126 30109813-1 2018 Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the sensor inositol-requiring enzyme 1alpha (IRE1), an endoribonuclease that splices the mRNA of the transcription factor XBP1 (X-box-binding protein 1). Inositol 88-96 X-box binding protein 1 Homo sapiens 199-203 30109813-1 2018 Adaptation to endoplasmic reticulum (ER) stress depends on the activation of the sensor inositol-requiring enzyme 1alpha (IRE1), an endoribonuclease that splices the mRNA of the transcription factor XBP1 (X-box-binding protein 1). Inositol 88-96 X-box binding protein 1 Homo sapiens 205-228 29562775-8 2018 Endoplasmic reticulum homeostasis was modified by supplementation, through the upregulation of PKR-like ER kinase (PERK) and inositol-requiring enzyme 1alpha (IRE1alpha). Inositol 125-133 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 159-168 29113024-5 2018 Furthermore, CBU protected cells against mitochondrial dysfunction and oxidative stress as indicated by the suppression of ROS accumulation and up regulation of the levels of GSH-Px and SOD. Inositol 13-16 glutathione peroxidase 1 Rattus norvegicus 175-189 29745333-0 2018 Alpha-lactalbumin Effect on Myo-inositol Intestinal Absorption: In vivo and In vitro. Inositol 28-40 lactalbumin alpha Homo sapiens 0-17 29745333-2 2018 Aim of this study was to determine if the combined oral administration of alpha-lactalbumin and myo-inositol in healthy subjects, could increase the plasma level of myo-inositol administered alone. Inositol 165-177 lactalbumin alpha Homo sapiens 74-91 29745333-9 2018 RESULTS: The bioavailability of myo-inositol was modified by the concomitant administration of alpha- lactalbumin. Inositol 32-44 lactalbumin alpha Homo sapiens 95-113 29745333-10 2018 Although peak concentration of myo-inositol at 180 min (Tmax) was similar for both treatments, administration of alpha-lactalbumin with myo-inositol in a single dose, significantly increased the plasma concentrations of myo-inositol compared to when administered alone. Inositol 136-148 lactalbumin alpha Homo sapiens 113-130 29745333-10 2018 Although peak concentration of myo-inositol at 180 min (Tmax) was similar for both treatments, administration of alpha-lactalbumin with myo-inositol in a single dose, significantly increased the plasma concentrations of myo-inositol compared to when administered alone. Inositol 136-148 lactalbumin alpha Homo sapiens 113-130 29745333-11 2018 In vitro, myo-inositol absorption in Caco-2 cells was improved in the presence of digested alpha-lactalbumin, and this change was associated with an increase in tight junction permeability. Inositol 10-22 lactalbumin alpha Homo sapiens 91-108 29745333-12 2018 CONCLUSION: Better myo-inositol absorption when orally administered with alpha-lactalbumin can be beneficial in non-responder patients. Inositol 19-31 lactalbumin alpha Homo sapiens 73-90 29745333-13 2018 Preliminary in vitro findings suggest that peptides deriving from alpha- lactalbumin digestion may modulate tight junction permeability allowing increased absorption of myoinositol. Inositol 169-180 lactalbumin alpha Homo sapiens 66-84 29276149-5 2018 We developed an original method based on fragment analysis that measures urinary levels of the spliced X-box binding protein 1 (sXBP1) mRNA as a proxy of inositol-requiring enzyme 1alpha (IRE1alpha) activity because sXBP1 is absolutely sensitive and specific for ER stress. Inositol 154-162 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 188-197 29052180-10 2018 CONCLUSION: Based on current evidence, myoinositol may be recommended for the treatment of PCOS with insulin resistance, as well as for improving symptoms caused by decreased estrogen in PCOS. Inositol 39-50 insulin Homo sapiens 101-108 29154199-6 2018 Importantly, UVB treatment perturbs the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and LC3-II turnover in response to treatment with MTOR inhibitors (Torin 1 and pp242), as well as endoplasmic reticular stress (A23187 and tunicamycin), inositol pathway (L690,330) and autophagy inducers (resveratrol and STF62247). Inositol 272-280 microtubule associated protein 1 light chain 3 alpha Homo sapiens 102-105 29154199-6 2018 Importantly, UVB treatment perturbs the conversion of microtubule-associated protein 1 light chain 3 (LC3)-I to LC3-II and LC3-II turnover in response to treatment with MTOR inhibitors (Torin 1 and pp242), as well as endoplasmic reticular stress (A23187 and tunicamycin), inositol pathway (L690,330) and autophagy inducers (resveratrol and STF62247). Inositol 272-280 mechanistic target of rapamycin kinase Homo sapiens 169-173 29417057-4 2017 Scs3p was initially identified because deletion leads to inositol auxotrophy, with an unusual sensitivity to addition of choline. Inositol 57-65 Scs3p Saccharomyces cerevisiae S288C 0-5 29206200-6 2017 Finally, in the milieu of TUNI-induced ERS, l-glutamine was found to maintain a high level of GRP78, alleviate CHOP-mediated apoptosis and activate the inositol requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) axis. Inositol 152-160 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 186-195 29354290-7 2017 In addition, IL-1beta activated all three well-known UPR pathways: protein kinase RNA-like ER kinase (PERK); activating transcription factor 6 (ATF-6); and inositol-requiring enzyme 1alpha (IRE1alpha). Inositol 156-164 interleukin 1 beta Homo sapiens 13-21 28965010-8 2017 The administration of combined IP6 and inositol supplement resulted in 64% and 27% increase in CAT activities and GSH levels respectively and a 25% decrease in lipid peroxidation level compared to the diabetic control. Inositol 39-47 catalase Rattus norvegicus 95-98 28917667-9 2017 Our results indicate that inositol-requiring protein-1/XBP1 activation is neuroprotective and enhances Abeta42 clearance. Inositol 26-34 X box binding protein-1 Drosophila melanogaster 55-59 29183107-0 2017 Insulin-sensitising drugs (metformin, rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility. Inositol 67-83 insulin Homo sapiens 0-7 28833202-4 2017 Efflux of uncharged osmolytes (myo-inositol and taurine) was suppressed by deletion of LRRC8A or LRRC8D, but not by deletion of LRRC8C+LRRC8E. Inositol 31-43 leucine rich repeat containing 8 VRAC subunit A Rattus norvegicus 87-93 28833202-4 2017 Efflux of uncharged osmolytes (myo-inositol and taurine) was suppressed by deletion of LRRC8A or LRRC8D, but not by deletion of LRRC8C+LRRC8E. Inositol 31-43 leucine rich repeat containing 8 VRAC subunit D Rattus norvegicus 97-103 29344438-6 2017 In this respect, much attention is given to the role of inositols, the mediators of insulin action. Inositol 56-65 insulin Homo sapiens 84-91 29344438-7 2017 A deficiency of d-chiro-inositol containing inositol-phospho-glycans may be the basis of insulin resistance frequently seen in PCOS patients. Inositol 16-32 insulin Homo sapiens 89-96 28924045-2 2017 Inositol depletion favors Opi1p interaction with both Scs2p and phosphatidic acid at the endoplasmic reticulum (ER) membrane. Inositol 0-8 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 26-31 28924045-2 2017 Inositol depletion favors Opi1p interaction with both Scs2p and phosphatidic acid at the endoplasmic reticulum (ER) membrane. Inositol 0-8 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 54-59 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 63-68 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 Ino2p Saccharomyces cerevisiae S288C 127-132 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 Ino4p Saccharomyces cerevisiae S288C 133-138 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 177-181 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 201-206 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 280-285 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 339-344 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 280-285 28924045-3 2017 Inositol supplementation, however, favors the translocation of Opi1p from the ER into the nucleus, where it interacts with the Ino2p-Ino4p complex, attenuating transcription of INO1 A strain devoid of Scs2p (scs2Delta) and a mutant, OPI1FFAT, lacking the ability to interact with Scs2p were utilized to examine the specific role(s) of the Opi1p-Scs2p interaction in the regulation of INO1 expression and overall lipid metabolism. Inositol 0-8 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 384-388 28924045-4 2017 Loss of the Opi1p-Scs2p interaction reduced INO1 expression and conferred inositol auxotrophy. Inositol 74-82 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 12-17 28924045-4 2017 Loss of the Opi1p-Scs2p interaction reduced INO1 expression and conferred inositol auxotrophy. Inositol 74-82 phosphatidylinositol-binding protein SCS2 Saccharomyces cerevisiae S288C 18-23 28924045-5 2017 Moreover, inositol depletion in strains lacking this interaction resulted in Opi1p being localized to sites of lipid droplet formation, coincident with increased synthesis of triacylglycerol. Inositol 10-18 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 77-82 28899778-4 2017 Here, we found that cells lacking Vma3p, one of the major V-ATPase assembly genes, had a growth defect in the absence of inositol, suggesting that Vma3p is important in phospholipid biosynthesis. Inositol 121-129 H(+)-transporting V0 sector ATPase subunit c Saccharomyces cerevisiae S288C 34-39 28882789-1 2017 A previous study found that inositol-requiring enzyme-1-X-box binding protein 1 (IRE1-XBP1) pathway and the protein kinase RNA (PKR)-like ER kinase-eIF2alpha (PERK-eIF2alpha) pathway of shrimp play roles in the unfolded protein response (UPR). Inositol 28-36 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 81-85 28882789-1 2017 A previous study found that inositol-requiring enzyme-1-X-box binding protein 1 (IRE1-XBP1) pathway and the protein kinase RNA (PKR)-like ER kinase-eIF2alpha (PERK-eIF2alpha) pathway of shrimp play roles in the unfolded protein response (UPR). Inositol 28-36 X-box binding protein 1 Homo sapiens 86-90 28882789-1 2017 A previous study found that inositol-requiring enzyme-1-X-box binding protein 1 (IRE1-XBP1) pathway and the protein kinase RNA (PKR)-like ER kinase-eIF2alpha (PERK-eIF2alpha) pathway of shrimp play roles in the unfolded protein response (UPR). Inositol 28-36 eukaryotic translation initiation factor 2A Homo sapiens 164-173 28849211-12 2017 In addition, the inositol-requiring enzyme 1 pathway mediated the ER stress associated with autophagy and inflammatory cytokines (IL1beta and caspase-1). Inositol 17-25 interleukin 1 beta Rattus norvegicus 130-137 28849211-12 2017 In addition, the inositol-requiring enzyme 1 pathway mediated the ER stress associated with autophagy and inflammatory cytokines (IL1beta and caspase-1). Inositol 17-25 caspase 1 Rattus norvegicus 142-151 28695546-2 2017 SMIT1 overexpression determines increased levels of intracellular myo-inositol, a precursor of phophoinositide synthesis. Inositol 66-78 solute carrier family 5 (inositol transporters), member 3 Mus musculus 0-5 28695546-5 2017 Considering the role of myo-inositol in intracellular signaling, we normalized SMIT1 expression in CTb cells using specific mRNA antisenses. Inositol 24-36 solute carrier family 5 (inositol transporters), member 3 Mus musculus 79-84 29241575-6 2017 Similarly, HFD-induced pyruvate kinase, liver, and RBC and fatty acid synthase protein levels in the liver were reduced by MI treatment. Inositol 123-125 pyruvate kinase L/R Rattus norvegicus 23-54 29241575-6 2017 Similarly, HFD-induced pyruvate kinase, liver, and RBC and fatty acid synthase protein levels in the liver were reduced by MI treatment. Inositol 123-125 fatty acid synthase Rattus norvegicus 59-78 29062910-3 2017 The response is orchestrated by three signalling pathways each activated by a specific signal transducer, either inositol requiring enzyme alpha (IRE1alpha), double-stranded RNA-activated protein kinase-like ER kinase (PERK) or activating transcription factor 6 (ATF6). Inositol 113-121 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 146-155 28980941-4 2017 These changes are associated with altered cortical myo-inositol and glycine levels, suggesting sleep loss-induced modifications downstream of mGluR5 signaling. Inositol 51-63 glutamate receptor, ionotropic, kainate 1 Mus musculus 142-148 29085625-3 2017 MIOX catalyzes the first reaction involved in the myo-inositol metabolism signaling pathway and is fully expressed in mammalian tissues. Inositol 50-62 myo-inositol oxygenase Homo sapiens 0-4 29085625-4 2017 MIOX catalyzes the oxidative cleavage of myo-Inositol and its epimer, D-chiro-Inositol to D-glucuronate. Inositol 41-53 myo-inositol oxygenase Homo sapiens 0-4 29085625-4 2017 MIOX catalyzes the oxidative cleavage of myo-Inositol and its epimer, D-chiro-Inositol to D-glucuronate. Inositol 70-86 myo-inositol oxygenase Homo sapiens 0-4 29085625-5 2017 The dioxygen-dependent cleavage of the C6 and C1 bond in myo-Inositol is achieved by utilizing the Fe2+/Fe3+ binuclear iron center of MIOX. Inositol 57-69 myo-inositol oxygenase Homo sapiens 134-138 28580641-5 2017 Under ER stress, melatonin significantly suppressed the induction of immunoglobulin heavy-chain-binding protein (BiP) and activation of inositol-requiring enzyme 1alpha (IRE1alpha), and their downstream target, alternative splicing of X-box binding protein 1(XBP1). Inositol 136-144 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 170-179 29153661-0 2017 PKB/Akt and MAPK/ERK phosphorylation is highly induced by inositols: Novel potential insights in endothelial dysfunction in preeclampsia. Inositol 58-67 AKT serine/threonine kinase 1 Homo sapiens 0-3 29153661-0 2017 PKB/Akt and MAPK/ERK phosphorylation is highly induced by inositols: Novel potential insights in endothelial dysfunction in preeclampsia. Inositol 58-67 AKT serine/threonine kinase 1 Homo sapiens 4-7 29153661-0 2017 PKB/Akt and MAPK/ERK phosphorylation is highly induced by inositols: Novel potential insights in endothelial dysfunction in preeclampsia. Inositol 58-67 mitogen-activated protein kinase 1 Homo sapiens 17-20 29153661-4 2017 To evaluate the pathophysiological significance of this response, the effect of myo-inositol and d-chiro inositol on the activation of PKB/Akt and MAPK/ERK was assessed in human endothelial cells in vitro. Inositol 80-92 AKT serine/threonine kinase 1 Homo sapiens 135-138 29153661-4 2017 To evaluate the pathophysiological significance of this response, the effect of myo-inositol and d-chiro inositol on the activation of PKB/Akt and MAPK/ERK was assessed in human endothelial cells in vitro. Inositol 80-92 AKT serine/threonine kinase 1 Homo sapiens 139-142 29153661-4 2017 To evaluate the pathophysiological significance of this response, the effect of myo-inositol and d-chiro inositol on the activation of PKB/Akt and MAPK/ERK was assessed in human endothelial cells in vitro. Inositol 80-92 mitogen-activated protein kinase 1 Homo sapiens 152-155 29153661-6 2017 Both inositols promoted a significantly higher PKB/Akt and MAPK/ERK phosphorylation than insulin. Inositol 5-14 AKT serine/threonine kinase 1 Homo sapiens 47-50 29153661-6 2017 Both inositols promoted a significantly higher PKB/Akt and MAPK/ERK phosphorylation than insulin. Inositol 5-14 AKT serine/threonine kinase 1 Homo sapiens 51-54 29153661-6 2017 Both inositols promoted a significantly higher PKB/Akt and MAPK/ERK phosphorylation than insulin. Inositol 5-14 mitogen-activated protein kinase 1 Homo sapiens 64-67 29153661-7 2017 Thus, exogenously administered inositols can activate PKB/Akt and MAPK/ERK in human endothelial cells in vitro. Inositol 31-40 AKT serine/threonine kinase 1 Homo sapiens 54-57 29153661-7 2017 Thus, exogenously administered inositols can activate PKB/Akt and MAPK/ERK in human endothelial cells in vitro. Inositol 31-40 AKT serine/threonine kinase 1 Homo sapiens 58-61 29153661-7 2017 Thus, exogenously administered inositols can activate PKB/Akt and MAPK/ERK in human endothelial cells in vitro. Inositol 31-40 mitogen-activated protein kinase 1 Homo sapiens 71-74 28757134-11 2017 Hepatic superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase activities were significantly upregulated by 55%, 26% and 53% respectively in the diabetic rats treated with combined IP6 and inositol compared to the diabetic control. Inositol 200-208 catalase Rattus norvegicus 30-38 28757134-11 2017 Hepatic superoxide dismutase, catalase, glucose-6-phosphate dehydrogenase activities were significantly upregulated by 55%, 26% and 53% respectively in the diabetic rats treated with combined IP6 and inositol compared to the diabetic control. Inositol 200-208 glucose-6-phosphate dehydrogenase Rattus norvegicus 40-73 28756231-5 2017 Through real-time PCR, we have shown that PAH1 is maximally induced at the stationary stage in the presence of inositol. Inositol 111-119 phosphatidate phosphatase PAH1 Saccharomyces cerevisiae S288C 42-46 28847931-3 2017 During ER stress, the inositol requiring enzyme 1alpha (IRE1alpha) endoribonuclease (RNase), a key mediator of the UPR, cleaves Xbp1 mRNA to generate a potent transcription factor adaptive toward ER stress. Inositol 22-30 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 56-65 28847931-3 2017 During ER stress, the inositol requiring enzyme 1alpha (IRE1alpha) endoribonuclease (RNase), a key mediator of the UPR, cleaves Xbp1 mRNA to generate a potent transcription factor adaptive toward ER stress. Inositol 22-30 X-box binding protein 1 Homo sapiens 128-132 28883483-6 2017 In AD-induced, TGF-beta1-treated compared to AD-induced hBMSCs, we identified 323 up- and 369 down-regulated genes (2.0 FC, p < 0.05) associated with "fat cell differentiation", "fatty acid derivative biosynthesis process", "fatty acid derivative metabolic process", and "inositol lipid-mediated". Inositol 275-283 transforming growth factor beta 1 Homo sapiens 15-24 28434274-0 2017 Myoinositol combined with alpha-lipoic acid may improve the clinical and endocrine features of polycystic ovary syndrome through an insulin-independent action. Inositol 0-11 insulin Homo sapiens 132-139 28581036-3 2017 Opi1p is a transcriptional repressor that is inactive when present at the nuclear membrane/endoplasmic reticulum, but represseses transcription of inositol upstream activating sequence (UASINO )-containing genes, many of which are involved in the synthesis of phospholipids and fatty acids, when it is translocated to the nucleus. Inositol 147-155 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 0-5 28832690-6 2017 To better understand the molecular mechanisms in these pathways, we developed a reporter construct that detects Inositol-requiring enzyme 1 (IRE1)-alpha mediated splicing of X-box binding protein 1 (XBP1) to monitor the course of UPR activation in cell lines expressing monoclonal antibodies. Inositol 112-120 X-box-binding protein 1 Cricetulus griseus 174-197 28832690-6 2017 To better understand the molecular mechanisms in these pathways, we developed a reporter construct that detects Inositol-requiring enzyme 1 (IRE1)-alpha mediated splicing of X-box binding protein 1 (XBP1) to monitor the course of UPR activation in cell lines expressing monoclonal antibodies. Inositol 112-120 X-box-binding protein 1 Cricetulus griseus 199-203 28835517-5 2017 Further investigation revealed that VCP inhibitors cooperated with M1 virus-suppressed inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) pathway and triggered irresolvable endoplasmic reticulum (ER) stress, subsequently promoting robust apoptosis in HCC. Inositol 87-95 valosin containing protein Homo sapiens 36-39 28835517-5 2017 Further investigation revealed that VCP inhibitors cooperated with M1 virus-suppressed inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) pathway and triggered irresolvable endoplasmic reticulum (ER) stress, subsequently promoting robust apoptosis in HCC. Inositol 87-95 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 121-130 28835517-5 2017 Further investigation revealed that VCP inhibitors cooperated with M1 virus-suppressed inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) pathway and triggered irresolvable endoplasmic reticulum (ER) stress, subsequently promoting robust apoptosis in HCC. Inositol 87-95 X-box binding protein 1 Homo sapiens 132-155 28835517-5 2017 Further investigation revealed that VCP inhibitors cooperated with M1 virus-suppressed inositol-requiring enzyme 1alpha (IRE1alpha)-X-box binding protein 1 (XBP1) pathway and triggered irresolvable endoplasmic reticulum (ER) stress, subsequently promoting robust apoptosis in HCC. Inositol 87-95 X-box binding protein 1 Homo sapiens 157-161 28817575-0 2017 MCK1 is a novel regulator of myo-inositol phosphate synthase (MIPS) that is required for inhibition of inositol synthesis by the mood stabilizer valproate. Inositol 33-41 serine/threonine/tyrosine protein kinase MCK1 Saccharomyces cerevisiae S288C 0-4 28817575-3 2017 The current study identifies Mck1, a GSK3 homolog, as a novel positive regulator of inositol de novo synthesis in yeast. Inositol 84-92 serine/threonine/tyrosine protein kinase MCK1 Saccharomyces cerevisiae S288C 29-33 28817575-3 2017 The current study identifies Mck1, a GSK3 homolog, as a novel positive regulator of inositol de novo synthesis in yeast. Inositol 84-92 serine/threonine protein kinase RIM11 Saccharomyces cerevisiae S288C 37-41 28817575-4 2017 Mck1 was required for normal activity of myo-inositol phosphate synthase (MIPS), which catalyzes the rate-limiting step of inositol synthesis. Inositol 45-53 serine/threonine/tyrosine protein kinase MCK1 Saccharomyces cerevisiae S288C 0-4 28817575-8 2017 These findings indicate that VPA-induced MIPS inhibition is Mck1-dependent, and suggest a model that unifies two current hypotheses of the mechanism of action of VPA-inositol depletion and GSK3 inhibition. Inositol 166-174 serine/threonine/tyrosine protein kinase MCK1 Saccharomyces cerevisiae S288C 60-64 28673963-5 2017 Immunoblot analysis showed that the elevation of PSS activity results from an increase in the level of the enzyme encoded by CHO1 Truncation analysis and site-directed mutagenesis of the CHO1 promoter indicated that Cho1 expression in the pah1Delta mutant is induced through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. Inositol 279-287 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 187-191 28673963-5 2017 Immunoblot analysis showed that the elevation of PSS activity results from an increase in the level of the enzyme encoded by CHO1 Truncation analysis and site-directed mutagenesis of the CHO1 promoter indicated that Cho1 expression in the pah1Delta mutant is induced through the inositol-sensitive upstream activation sequence (UASINO), a cis-acting element for the phosphatidate-controlled Henry (Ino2-Ino4/Opi1) regulatory circuit. Inositol 279-287 CDP-diacylglycerol-serine O-phosphatidyltransferase Saccharomyces cerevisiae S288C 216-220 28719181-9 2017 Structures of mutant complexes with inositol or methyl-mannose revealed an attenuation of the ligand-induced conformational change relative to wild-type SP-A. Inositol 36-44 surfactant protein A1 Homo sapiens 153-157 28793216-9 2017 We conclude that, independent of its transport activity and indirect regulatory mechanisms involving inositol-derived increases in PIP2, SMIT1, and likely other related sodium-dependent solute transporters, regulates KCNQ channel ion selectivity, gating, and pharmacology by direct physical interaction with the pore module. Inositol 101-109 solute carrier family 5 member 3 Homo sapiens 137-142 28600316-7 2017 This study demonstrates an alternative method to produce myo-inositol from starch with an in vitro enzyme system using thermostable maltodextrin phosphorylase (MalP), phosphoglucomutase (PGM), myo-inositol-3-phosphate synthase, and myo-inositol monophosphatase. Inositol 57-69 phosphoglucomutase Solanum tuberosum 167-185 28600316-7 2017 This study demonstrates an alternative method to produce myo-inositol from starch with an in vitro enzyme system using thermostable maltodextrin phosphorylase (MalP), phosphoglucomutase (PGM), myo-inositol-3-phosphate synthase, and myo-inositol monophosphatase. Inositol 57-69 phosphoglucomutase Solanum tuberosum 187-190 28600316-8 2017 By utilizing MalP and PGM to generate glucose 6-phosphate, we can avoid the addition of phosphate donors such as ATP, the use of which would not be practical for scaled-up production of myo-inositol. Inositol 186-198 phosphoglucomutase Solanum tuberosum 22-25 28485095-7 2017 RT-PCR demonstrated that compared with metformin, myo-inositol downregulated gene expression of interleukin-1 (IL-1) (P=.02) in PBMCs of subjects with PCOS. Inositol 50-62 interleukin 1 alpha Homo sapiens 96-116 28485095-9 2017 CONCLUSIONS: Overall, taking myo-inositol, compared with metformin, for 12 weeks in patients with PCOS with hyperinsulinism and normoinsulinism had beneficial effects on total testosterone, mFG scores, serum hs-CRP levels and gene expression of IL-1, but did not affect other hormonal profiles, NO levels or gene expression of IL-8 and TNF-alpha. Inositol 29-41 interleukin 1 alpha Homo sapiens 245-249 28485095-9 2017 CONCLUSIONS: Overall, taking myo-inositol, compared with metformin, for 12 weeks in patients with PCOS with hyperinsulinism and normoinsulinism had beneficial effects on total testosterone, mFG scores, serum hs-CRP levels and gene expression of IL-1, but did not affect other hormonal profiles, NO levels or gene expression of IL-8 and TNF-alpha. Inositol 29-41 C-X-C motif chemokine ligand 8 Homo sapiens 327-331 28485095-9 2017 CONCLUSIONS: Overall, taking myo-inositol, compared with metformin, for 12 weeks in patients with PCOS with hyperinsulinism and normoinsulinism had beneficial effects on total testosterone, mFG scores, serum hs-CRP levels and gene expression of IL-1, but did not affect other hormonal profiles, NO levels or gene expression of IL-8 and TNF-alpha. Inositol 29-41 tumor necrosis factor Homo sapiens 336-345 28175933-2 2017 We have previously shown that the negative regulator Opi1 of yeast phospholipid biosynthesis inhibits transcription by recruiting corepressors Sin3 and Cyc8 in the presence of precursor molecules inositol and choline. Inositol 196-204 transcriptional regulator OPI1 Saccharomyces cerevisiae S288C 53-57 28175933-2 2017 We have previously shown that the negative regulator Opi1 of yeast phospholipid biosynthesis inhibits transcription by recruiting corepressors Sin3 and Cyc8 in the presence of precursor molecules inositol and choline. Inositol 196-204 transcriptional regulator SIN3 Saccharomyces cerevisiae S288C 143-147 28175933-2 2017 We have previously shown that the negative regulator Opi1 of yeast phospholipid biosynthesis inhibits transcription by recruiting corepressors Sin3 and Cyc8 in the presence of precursor molecules inositol and choline. Inositol 196-204 transcription regulator CYC8 Saccharomyces cerevisiae S288C 152-156 28347804-7 2017 The oncogenic effect of OGT was investigated, we found that OGT significantly induced palmitic acid production identified by LC-MS, which enhanced the protein expression of endoplasmic reticulum (ER) stress masters of glucose-regulated protein 78 and inositol-requiring enzyme 1alpha. Inositol 251-259 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Mus musculus 24-27 28347804-7 2017 The oncogenic effect of OGT was investigated, we found that OGT significantly induced palmitic acid production identified by LC-MS, which enhanced the protein expression of endoplasmic reticulum (ER) stress masters of glucose-regulated protein 78 and inositol-requiring enzyme 1alpha. Inositol 251-259 O-linked N-acetylglucosamine (GlcNAc) transferase (UDP-N-acetylglucosamine:polypeptide-N-acetylglucosaminyl transferase) Mus musculus 60-63 28087886-1 2017 SCOPE: d-chiro inositol (DCI), an isomer of inositol, possesses anti-oxidative and endothelial protective properties. Inositol 15-23 enoyl-CoA delta isomerase 1 Rattus norvegicus 25-28 28155228-6 2017 Moreover, HOP3 is induced both at transcript and protein levels by unfolded protein response (UPR) inducer agents by a mechanism dependent on inositol-requiring enzyme 1 (IRE1). Inositol 142-150 stress-inducible protein Arabidopsis thaliana 10-14 28667101-8 2017 We found that Sigmar1 overexpression significantly increased inositol requiring kinase 1alpha (IRE1alpha) phosphorylation and increased spliced X-box-binding proteins (XBP1s) expression as well as nuclear localization. Inositol 61-69 sigma non-opioid intracellular receptor 1 Rattus norvegicus 14-21 28714880-0 2017 Upregulation of Phosphatidylinositol 3-Kinase (PI3K) Enhances Ethylene Biosynthesis and Accelerates Flower Senescence in Transgenic Nicotiana tabacum L. Phosphatidylinositol 3-kinase (PI3K) is a key enzyme that phosphorylates phosphatidylinositol at 3"-hydroxyl position of the inositol head group initiating the generation of several phosphorylated phosphatidylinositols, collectively referred to as phosphoinositides. Inositol 28-36 phosphatidylinositol 3-kinase, root isoform Nicotiana tabacum 153-182 28283543-2 2017 KCNQ2/3 channel activity is augmented in vivo by phosphatidylinositol 4,5-bisphosphate (PIP2), which is generated from myo-inositol, an osmolyte transported into cells by sodium-dependent myo-inositol transporters (SMITs). Inositol 119-131 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 0-5 28283543-2 2017 KCNQ2/3 channel activity is augmented in vivo by phosphatidylinositol 4,5-bisphosphate (PIP2), which is generated from myo-inositol, an osmolyte transported into cells by sodium-dependent myo-inositol transporters (SMITs). Inositol 188-200 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 0-5 28283543-3 2017 Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K+], and KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation. Inositol 431-443 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 25-30 28283543-3 2017 Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K+], and KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation. Inositol 431-443 solute carrier family 5 member 3 Homo sapiens 79-84 28283543-3 2017 Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K+], and KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation. Inositol 431-443 solute carrier family 5 member 11 Homo sapiens 89-94 28283543-3 2017 Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K+], and KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation. Inositol 431-443 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 219-224 28283543-3 2017 Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K+], and KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation. Inositol 431-443 solute carrier family 5 member 3 Homo sapiens 250-255 28283543-3 2017 Here, we discovered that KCNQ2/3 channels isoform-specifically colocalize with SMIT1 and SMIT2 at sciatic nerve nodes of Ranvier and in axon initial segments, and form channel-transporter complexes in vitro and in vivo KCNQ2/3 coexpression protected SMIT1 activity from the otherwise inhibitory effects of cellular depolarization imposed by elevating extracellular [K+], and KCNQ2 was required for potentiation of SMIT activity by myo-inositol preincubation. Inositol 431-443 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 219-224 28283543-4 2017 Cytoskeletal disruption, which speeds PIP2 dispersion, attenuated potentiation of KCNQ2/3 currents by SMIT1-mediated myo-inositol uptake, suggesting close channel-transporter juxtaposition ensures KCNQ2/3 exposure to locally high myo-inositol-derived PIP2 concentrations. Inositol 117-129 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 82-87 28283543-4 2017 Cytoskeletal disruption, which speeds PIP2 dispersion, attenuated potentiation of KCNQ2/3 currents by SMIT1-mediated myo-inositol uptake, suggesting close channel-transporter juxtaposition ensures KCNQ2/3 exposure to locally high myo-inositol-derived PIP2 concentrations. Inositol 117-129 solute carrier family 5 member 3 Homo sapiens 102-107 28283543-4 2017 Cytoskeletal disruption, which speeds PIP2 dispersion, attenuated potentiation of KCNQ2/3 currents by SMIT1-mediated myo-inositol uptake, suggesting close channel-transporter juxtaposition ensures KCNQ2/3 exposure to locally high myo-inositol-derived PIP2 concentrations. Inositol 230-242 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 82-87 28283543-4 2017 Cytoskeletal disruption, which speeds PIP2 dispersion, attenuated potentiation of KCNQ2/3 currents by SMIT1-mediated myo-inositol uptake, suggesting close channel-transporter juxtaposition ensures KCNQ2/3 exposure to locally high myo-inositol-derived PIP2 concentrations. Inositol 230-242 solute carrier family 5 member 3 Homo sapiens 102-107 28347999-6 2017 Fatty acid incorporation and lipidomics analyses showed that LPIN1 knockdown blocks phospholipid synthesis and changes membrane lipid compositions that ultimately induce the activation of 1 of the 3 branches of unfolded protein responses, the inositol-requiring enzyme-1alpha pathway. Inositol 243-251 lipin 1 Homo sapiens 61-66 28557834-5 2017 Compared with myometrial invasion (MI), the HE4 values were significantly higher in case of invasion of greater than 50% of the thickness: MI of greater than 50%, median of 94.85 pmol/L (38.3-820.8 pmol/L), versus MI of less than 50%, median of 65.65 pmol/L (25.1-360.2 pmol/L), (P < 0.001). Inositol 35-37 WAP four-disulfide core domain 2 Homo sapiens 44-47 28557834-5 2017 Compared with myometrial invasion (MI), the HE4 values were significantly higher in case of invasion of greater than 50% of the thickness: MI of greater than 50%, median of 94.85 pmol/L (38.3-820.8 pmol/L), versus MI of less than 50%, median of 65.65 pmol/L (25.1-360.2 pmol/L), (P < 0.001). Inositol 139-141 WAP four-disulfide core domain 2 Homo sapiens 44-47 27826097-10 2017 The H2O2-induced CXCL16 expression was due to the activation of 2 unfolded protein response pathways: kinase RNA (PKR)-like ER kinase-eukaryotic initiation factor 2alpha and inositol-requiring enzyme 1alpha-X-box binding protein 1. Inositol 174-182 C-X-C motif chemokine ligand 16 Homo sapiens 17-23 28674530-6 2017 Indeed, stimulation of DCs with PAMPs in the presence of 2-DG robustly activated inositol-requiring protein 1alpha (IRE1alpha) signaling and to a lesser extent the PERK arm of the unfolded protein response. Inositol 81-89 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 116-125 28428258-1 2017 Inositol-requiring enzyme-1alpha (IRE1alpha) is an endoplasmic reticulum (ER)-transmembrane endoribonuclease kinase that plays an essential function in extraembryonic tissues during normal development and is activated during ER stress. Inositol 0-8 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 34-43 28455416-3 2017 For one, NuA4 mutants induce the expression of the inositol-3-phosphate synthase gene, INO1, which leads to excessive accumulation of inositol, a key metabolite used for phospholipid biosynthesis. Inositol 51-59 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 87-91 28455416-6 2017 Transcriptome studies reveal that while loss of the NuA4 subunit EAF1 in sec14-1ts does derepress INO1 expression, it does not derepress all inositol/choline-responsive phospholipid genes, suggesting that the impact of Eaf1 on phospholipid homeostasis extends beyond inositol biosynthesis. Inositol 267-275 Eaf1p Saccharomyces cerevisiae S288C 65-69 28588082-2 2017 The UPR components X-box binding protein 1 (XBP1) and inositol-requiring enzyme 1alpha (IRE1alpha) promote type I interferon (IFN) responses. Inositol 54-62 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 88-97 28588082-2 2017 The UPR components X-box binding protein 1 (XBP1) and inositol-requiring enzyme 1alpha (IRE1alpha) promote type I interferon (IFN) responses. Inositol 54-62 interferon alpha 1 Homo sapiens 126-129 28724173-0 2017 A comparative study between myo-inositol and metformin in the treatment of insulin-resistant women. Inositol 28-40 insulin Homo sapiens 75-82 28724176-1 2017 Myo-inositol (MYO) usually represents a therapeutic option for female infertility associated with insulin resistance. Inositol 0-12 insulin Homo sapiens 98-105 28724176-1 2017 Myo-inositol (MYO) usually represents a therapeutic option for female infertility associated with insulin resistance. Inositol 14-17 insulin Homo sapiens 98-105 28724177-9 2017 RESULTS: The rationale underlying the use of inositols as a therapeutic application in PCOS derives from their activities as insulin mimetic agents and their salutary effects on metabolism and hyperandrogenism without side effects. Inositol 45-54 insulin Homo sapiens 125-132 28724178-3 2017 The management of insulin resistance is crucial in the treatment of PCOS and insulin-sensitizing molecule as myo-inositol (MYO) seems to have promising effects. Inositol 109-121 insulin Homo sapiens 18-25 28724178-3 2017 The management of insulin resistance is crucial in the treatment of PCOS and insulin-sensitizing molecule as myo-inositol (MYO) seems to have promising effects. Inositol 109-121 insulin Homo sapiens 77-84 28724178-3 2017 The management of insulin resistance is crucial in the treatment of PCOS and insulin-sensitizing molecule as myo-inositol (MYO) seems to have promising effects. Inositol 123-126 insulin Homo sapiens 18-25 28724178-3 2017 The management of insulin resistance is crucial in the treatment of PCOS and insulin-sensitizing molecule as myo-inositol (MYO) seems to have promising effects. Inositol 123-126 insulin Homo sapiens 77-84 28131704-13 2017 Furthermore, Notch3 KO mice subjected to MI had increased intracellular adhesion molecule-2 (ICAM-2) expression and CD11b+ macrophage infiltration into ischemic areas compared to that of WT mice. Inositol 41-43 notch 3 Mus musculus 13-19 28131704-13 2017 Furthermore, Notch3 KO mice subjected to MI had increased intracellular adhesion molecule-2 (ICAM-2) expression and CD11b+ macrophage infiltration into ischemic areas compared to that of WT mice. Inositol 41-43 intercellular adhesion molecule 2 Mus musculus 58-91 28131704-13 2017 Furthermore, Notch3 KO mice subjected to MI had increased intracellular adhesion molecule-2 (ICAM-2) expression and CD11b+ macrophage infiltration into ischemic areas compared to that of WT mice. Inositol 41-43 intercellular adhesion molecule 2 Mus musculus 93-99 28131704-13 2017 Furthermore, Notch3 KO mice subjected to MI had increased intracellular adhesion molecule-2 (ICAM-2) expression and CD11b+ macrophage infiltration into ischemic areas compared to that of WT mice. Inositol 41-43 integrin alpha M Mus musculus 116-121 27195938-6 2017 The results indicate that expression of FST1 in an ITR1 mutant strain restores growth on myo-inositol medium to wild-type levels and restores the inhibitory effects of FB1, suggesting that FST1 can transport both myo-inositol and FB1 into yeast cells. Inositol 89-101 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 51-55 27195938-6 2017 The results indicate that expression of FST1 in an ITR1 mutant strain restores growth on myo-inositol medium to wild-type levels and restores the inhibitory effects of FB1, suggesting that FST1 can transport both myo-inositol and FB1 into yeast cells. Inositol 213-225 myo-inositol transporter ITR1 Saccharomyces cerevisiae S288C 51-55 28539652-2 2017 In this experiment, we investigated the function of ANO1 in cardiac fibrosis after myocardial infraction (MI) with methods of Western blotting, Quantitative real-time PCR (qRT-PCR), metabolic reduction of 3-(4,5-dimethylthiozol-2-yl)-2, 5-diphenyltetrazo-lium bromide (MTT), immunofluorescence and confocal imaging, and Masson"s trichrome staining. Inositol 106-108 anoctamin 1 Rattus norvegicus 52-56 28539652-3 2017 The results showed that the expression of ANO1 significantly increased in neonatal rats" cardiac fibroblasts after hypoxia and in cardiac tissues after MI. Inositol 152-154 anoctamin 1 Rattus norvegicus 42-46 28539652-6 2017 In conclusion, ANO1 inhibits cardiac fibrosis after MI via TGF-beta/smad3 pathway in rats. Inositol 52-54 anoctamin 1 Rattus norvegicus 15-19 28132498-4 2017 Through manipulating different regulators including Ino2p, Ino4p, Opi1p, and a series of synthetic Ino2p variants, combining with studying the inositol and choline effect, the engineered strain achieved a 9-fold increase of the titer of malonyl-CoA-derived product 3-hydroxypropionic acid, which is among the highest improvement relative to previously reported strategies. Inositol 143-151 Ino2p Saccharomyces cerevisiae S288C 52-57 28132498-4 2017 Through manipulating different regulators including Ino2p, Ino4p, Opi1p, and a series of synthetic Ino2p variants, combining with studying the inositol and choline effect, the engineered strain achieved a 9-fold increase of the titer of malonyl-CoA-derived product 3-hydroxypropionic acid, which is among the highest improvement relative to previously reported strategies. Inositol 143-151 Ino2p Saccharomyces cerevisiae S288C 99-104 28938597-5 2017 Interestingly, DC also activated the endoplasmic reticulum (ER) stress response that promotes autophagy via p62 transcriptional activation involving the inositol-requiring enzyme 1alpha/c-Jun N-terminal kinase/c-jun pathway. Inositol 153-161 nucleoporin 62 Homo sapiens 108-111 28938597-5 2017 Interestingly, DC also activated the endoplasmic reticulum (ER) stress response that promotes autophagy via p62 transcriptional activation involving the inositol-requiring enzyme 1alpha/c-Jun N-terminal kinase/c-jun pathway. Inositol 153-161 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 186-191 28938597-5 2017 Interestingly, DC also activated the endoplasmic reticulum (ER) stress response that promotes autophagy via p62 transcriptional activation involving the inositol-requiring enzyme 1alpha/c-Jun N-terminal kinase/c-jun pathway. Inositol 153-161 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 210-215 28284757-13 2017 CONCLUSION: C-kit+ CSC and/or BM-MSC transplantation can improve cardiac function after MI in a paracrine manner. Inositol 88-90 KIT proto-oncogene, receptor tyrosine kinase Homo sapiens 12-17 28346409-4 2017 Here, we identified inositol-requiring enzyme 1alpha (IRE1alpha) as a critical switch governing M1-M2 macrophage polarization and energy balance. Inositol 20-28 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 54-63 28244322-3 2017 However, when in combination with doxorubicin and methotrexate, Pd2Spm induced strong metabolic deviations on lipids, choline compounds, amino acids, nucleotides, and compounds related to antioxidative mechanisms (e.g., glutathione, inositol, hypoxanthine), similarly to the cDDP cocktail. Inositol 233-241 PAF1 homolog, Paf1/RNA polymerase II complex component Homo sapiens 64-67 28327767-1 2017 Triflates of myo-inositol undergo facile solvolysis in DMSO and DMF yielding SN2 products substituted with O-nucleophiles; DMF showed slower kinetics. Inositol 13-25 solute carrier family 38 member 5 Homo sapiens 77-80 28325868-5 2017 InsPs activate IDE by up to ~95-fold, affecting primarily Vmax The extent of activation and binding affinity correlate with the number of phosphate groups on the inositol ring, with phosphate positional effects observed. Inositol 162-170 insulin degrading enzyme Homo sapiens 15-18 28039583-2 2017 Similarly to metformin, D-chiro-inositol (DCI), as putative mediator of intracellular insulin action, can act as insulin sensitizer. Inositol 24-40 insulin Homo sapiens 86-93 28039583-2 2017 Similarly to metformin, D-chiro-inositol (DCI), as putative mediator of intracellular insulin action, can act as insulin sensitizer. Inositol 24-40 insulin Homo sapiens 113-120 28192884-0 2017 Myoinositol ameliorates high-fat diet and streptozotocin-induced diabetes in rats through promoting insulin receptor signaling. Inositol 0-11 insulin receptor Rattus norvegicus 100-116 28192884-11 2017 Myoinositol enhanced the level of PPARgamma expression in the adipose tissue of treated rats when compared with rats that did not receive drug treatment; also, it significantly upregulated GLUT4 and IR signaling molecules. Inositol 0-11 peroxisome proliferator-activated receptor gamma Rattus norvegicus 34-43 28192884-11 2017 Myoinositol enhanced the level of PPARgamma expression in the adipose tissue of treated rats when compared with rats that did not receive drug treatment; also, it significantly upregulated GLUT4 and IR signaling molecules. Inositol 0-11 solute carrier family 2 member 4 Rattus norvegicus 189-194 28192884-12 2017 Myoinositol had predicted the interactions within the active sites of PPARgamma, GLUT4 and IR. Inositol 0-11 peroxisome proliferator-activated receptor gamma Rattus norvegicus 70-79 28192884-12 2017 Myoinositol had predicted the interactions within the active sites of PPARgamma, GLUT4 and IR. Inositol 0-11 solute carrier family 2 member 4 Rattus norvegicus 81-86 29098149-2 2017 The most conserved arm of the UPR, inositol-requiring ER-to-nucleus signaling protein (IRE1alpha), has been linked to the regulation of a diverse array of cellular processes including ER-associated degradation, inflammatory signaling, cell proliferation and membrane biogenesis. Inositol 35-43 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 87-96 28193731-4 2017 We show that, besides the osmolytes taurine and myo-inositol, LRRC8 channels transport the neurotransmitters glutamate, aspartate and gamma-aminobutyric acid (GABA) and the co-activator D-serine. Inositol 48-60 leucine rich repeat containing 8 VRAC subunit A Homo sapiens 62-67 28193731-6 2017 Whereas LRRC8D was crucial for the translocation of overall neutral compounds like myo-inositol, taurine and GABA, and sustained the transport of positively charged lysine, flux of negatively charged aspartate was equally well supported by LRRC8E. Inositol 83-95 leucine rich repeat containing 8 VRAC subunit D Homo sapiens 8-14 28273837-2 2017 Class (I) PI3Ks (PI3Kalpha, PI3Kbeta, PI3Kgamma and PI3Kdelta) mediate the phosphorylation of the inositol ring at position D3 leading to the generation of PtdIns(3,4,5)P3. Inositol 98-106 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha Homo sapiens 17-26 28273837-2 2017 Class (I) PI3Ks (PI3Kalpha, PI3Kbeta, PI3Kgamma and PI3Kdelta) mediate the phosphorylation of the inositol ring at position D3 leading to the generation of PtdIns(3,4,5)P3. Inositol 98-106 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta Homo sapiens 28-36 28273837-2 2017 Class (I) PI3Ks (PI3Kalpha, PI3Kbeta, PI3Kgamma and PI3Kdelta) mediate the phosphorylation of the inositol ring at position D3 leading to the generation of PtdIns(3,4,5)P3. Inositol 98-106 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma Homo sapiens 38-47 28273837-2 2017 Class (I) PI3Ks (PI3Kalpha, PI3Kbeta, PI3Kgamma and PI3Kdelta) mediate the phosphorylation of the inositol ring at position D3 leading to the generation of PtdIns(3,4,5)P3. Inositol 98-106 phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta Homo sapiens 52-61 28314264-5 2017 Cyclosporine A induced the inositol requiring enzyme-1alpha (IRE1alpha) arm of the UPR and stabilized neosynthesized proteins in RCC cells. Inositol 27-35 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 61-70 28098884-7 2017 Phosphorylated inositol-requiring 1alpha (p-IRE1alpha), an ER stress marker protein, was mainly expressed in macrophages in the atherosclerotic lesions. Inositol 15-23 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 44-53 28039331-1 2017 The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the UPR is important in lipid metabolism. Inositol 100-108 X-box binding protein 1 Mus musculus 133-156 28039331-1 2017 The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the UPR is important in lipid metabolism. Inositol 100-108 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 158-167 28039331-1 2017 The unfolded protein response (UPR) is an adaptive response to endoplasmic reticulum stress and the inositol-requiring enzyme 1alpha/X-box binding protein 1 (IRE1alpha/XBP1) pathway of the UPR is important in lipid metabolism. Inositol 100-108 X-box binding protein 1 Mus musculus 168-172 28454221-1 2017 The endoplasmic reticulum stress inositol-requiring enzyme (IRE) 1alpha/X-box binding protein (XBP) 1 signaling pathway is involved in the tumorigenesis of breast and prostate cancer. Inositol 33-41 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 60-71 27998795-5 2017 Our results indicate that thrombin, acting on protease-activated receptor 1 (PAR1) increases cytosolic Ca2+ concentration in RBMVEC via Ca2+ release from endoplasmic reticulum through inositol 1,4,5-trisphosphate receptors and Ca2+ influx from extracellular space. Inositol 184-192 coagulation factor II Rattus norvegicus 26-34 27998795-5 2017 Our results indicate that thrombin, acting on protease-activated receptor 1 (PAR1) increases cytosolic Ca2+ concentration in RBMVEC via Ca2+ release from endoplasmic reticulum through inositol 1,4,5-trisphosphate receptors and Ca2+ influx from extracellular space. Inositol 184-192 coagulation factor II (thrombin) receptor Rattus norvegicus 46-75 27998795-5 2017 Our results indicate that thrombin, acting on protease-activated receptor 1 (PAR1) increases cytosolic Ca2+ concentration in RBMVEC via Ca2+ release from endoplasmic reticulum through inositol 1,4,5-trisphosphate receptors and Ca2+ influx from extracellular space. Inositol 184-192 coagulation factor II (thrombin) receptor Rattus norvegicus 77-81 26868665-9 2017 These insights may help to understand pathogenesis and tissue specificity in SCA2 and other polyQ ataxias like SCA1, where inositol regulation of calcium flux and RORalpha play a role. Inositol 123-131 ataxin 2 Mus musculus 77-81 26868665-9 2017 These insights may help to understand pathogenesis and tissue specificity in SCA2 and other polyQ ataxias like SCA1, where inositol regulation of calcium flux and RORalpha play a role. Inositol 123-131 ataxin 1 Mus musculus 111-115 27436854-1 2017 The ribonuclease angiogenin is a component of the mammalian stress response that is secreted by renal epithelial cells on activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-active spliced X-box binding protein 1 (sXBP1) axis and instrumental to the adaptation to AKI associated with endoplasmic reticulum stress. Inositol 140-148 angiogenin Homo sapiens 17-27 27436854-1 2017 The ribonuclease angiogenin is a component of the mammalian stress response that is secreted by renal epithelial cells on activation of the inositol-requiring enzyme 1alpha (IRE1alpha)-active spliced X-box binding protein 1 (sXBP1) axis and instrumental to the adaptation to AKI associated with endoplasmic reticulum stress. Inositol 140-148 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 174-183 27743455-2 2017 Gene expression is stimulated by the heterodimeric activator Ino2/Ino4, which binds to ICRE (inositol/choline-responsive element) promoter sequences. Inositol 93-101 Ino2p Saccharomyces cerevisiae S288C 61-65 27743455-2 2017 Gene expression is stimulated by the heterodimeric activator Ino2/Ino4, which binds to ICRE (inositol/choline-responsive element) promoter sequences. Inositol 93-101 Ino4p Saccharomyces cerevisiae S288C 66-70 28128227-7 2017 In contrast, myo-inositol (transported through SMIT1) reproduced the toxic effects of HG. Inositol 13-25 solute carrier family 5 member 3 Homo sapiens 47-52 28114319-3 2017 In genetic screens using the multidendritic arbor of PVD somatosensory neurons in the nematode Caenorhabditis elegans, we identified a mutation in the ER stress sensor IRE-1/Ire1 (inositol requiring enzyme 1) as crucial for proper PVD dendrite arborization in vivo. Inositol 180-188 Endoribonuclease;Serine/threonine-protein kinase Caenorhabditis elegans 168-173 28114319-3 2017 In genetic screens using the multidendritic arbor of PVD somatosensory neurons in the nematode Caenorhabditis elegans, we identified a mutation in the ER stress sensor IRE-1/Ire1 (inositol requiring enzyme 1) as crucial for proper PVD dendrite arborization in vivo. Inositol 180-188 Endoribonuclease;Serine/threonine-protein kinase Caenorhabditis elegans 174-178 28119806-2 2017 Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin (mTOR) to play key roles in carcinogenesis. Inositol 63-71 AKT serine/threonine kinase 1 Homo sapiens 214-217 28119806-2 2017 Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin (mTOR) to play key roles in carcinogenesis. Inositol 63-71 mechanistic target of rapamycin kinase Homo sapiens 252-281 28119806-2 2017 Class I PI3Ks are lipid kinases that phosphorylate phosphatidylinositol 4,5-bisphosphate (PIP2) at the 3-OH of the inositol ring to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3), which in turn activates Akt and the downstream effectors like mammalian target of rapamycin (mTOR) to play key roles in carcinogenesis. Inositol 63-71 mechanistic target of rapamycin kinase Homo sapiens 283-287 28867746-6 2017 We found that MeHg specifically attenuated inositol-requiring enzyme 1alpha (IRE1alpha)-x-box binding protein 1 (XBP1) branch, but not the protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcriptional factor 6 (ATF6) branches. Inositol 43-51 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 77-86 28867746-6 2017 We found that MeHg specifically attenuated inositol-requiring enzyme 1alpha (IRE1alpha)-x-box binding protein 1 (XBP1) branch, but not the protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcriptional factor 6 (ATF6) branches. Inositol 43-51 X-box binding protein 1 Homo sapiens 88-111 28867746-6 2017 We found that MeHg specifically attenuated inositol-requiring enzyme 1alpha (IRE1alpha)-x-box binding protein 1 (XBP1) branch, but not the protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcriptional factor 6 (ATF6) branches. Inositol 43-51 X-box binding protein 1 Homo sapiens 113-117 29130967-4 2017 RESULTS: Mutant p53 cells exhibited increased expression of the C/EBP homologous protein (CHOP), glucose-regulated protein 78 (GRP78), and inositol-requiring enzyme-1alpha (IRE1alpha). Inositol 139-147 tumor protein p53 Homo sapiens 16-19 28875849-0 2017 Modulation of both Insulin Resistance and Cancer Growth by Inositol. Inositol 59-67 insulin Homo sapiens 19-26 28875849-2 2017 Conversely, a number of synthetic and natural insulin sensitizers, including inositol, have been recognized to exert both anti-diabetic as well as anti-cancer properties. Inositol 77-85 insulin Homo sapiens 46-53 28875849-3 2017 Inositol participates in insulin transduction signaling, and deregulated inositol metabolism has been ascertained in several conditions associated with insulin resistance. Inositol 0-8 insulin Homo sapiens 25-32 28875849-3 2017 Inositol participates in insulin transduction signaling, and deregulated inositol metabolism has been ascertained in several conditions associated with insulin resistance. Inositol 73-81 insulin Homo sapiens 152-159 28875849-5 2017 Additionally, inositol may directly interfere with both glucose metabolism and carcinogenesis by modulating a number of critical processes downstream of insulin stimulation, including anti-oxidant defenses, oxidative glucose metabolism and endocrine modulation. Inositol 14-22 insulin Homo sapiens 153-160 28875849-6 2017 A selected cluster of biochemical factors (PI3K/Akt, PDH and AMPK-related pathways), that are presently considered putative targets for anticancer treatments, are also specifically modulated by inositol or its derivatives. Inositol 194-202 AKT serine/threonine kinase 1 Homo sapiens 48-51 28875849-6 2017 A selected cluster of biochemical factors (PI3K/Akt, PDH and AMPK-related pathways), that are presently considered putative targets for anticancer treatments, are also specifically modulated by inositol or its derivatives. Inositol 194-202 pyruvate dehydrogenase phosphatase catalytic subunit 1 Homo sapiens 53-56 28875849-7 2017 What is more, studies on inositol mechanism of action paved the way in understanding that both insulin resistance and cancer share a few perturbed, critical biochemical pathways. Inositol 25-33 insulin Homo sapiens 95-102 28875849-9 2017 Thereby, inositol fulfills the requirement to target both insulin resistance and cancer, and its clinical usefulness deserves to be adequately addressed by specific, randomized trials. Inositol 9-17 insulin Homo sapiens 58-65 27808588-2 2017 Insulin-sensitizer agents such as metformin and inositols have been shown to improve the endocrine and metabolic aspects of PCOS. Inositol 48-57 insulin Homo sapiens 0-7 27808588-12 2017 The two insulin-sensitizers, metformin and myo-inositol, show to be useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle without significant differences between the two treatments. Inositol 43-55 insulin Homo sapiens 8-15 27808588-12 2017 The two insulin-sensitizers, metformin and myo-inositol, show to be useful in PCOS women in lowering BMI and ameliorating insulin sensitivity, and improving menstrual cycle without significant differences between the two treatments. Inositol 43-55 insulin Homo sapiens 122-129 27898267-4 2017 Recently, inositols - myo-inositol (MI) and D-chiro-inositol (DCI) - have shown to be an efficient and safe alternative in PCOS management, as both inositol isoforms are able to counteract downstream consequences of insulin resistance. Inositol 44-60 insulin Homo sapiens 216-223 27898267-4 2017 Recently, inositols - myo-inositol (MI) and D-chiro-inositol (DCI) - have shown to be an efficient and safe alternative in PCOS management, as both inositol isoforms are able to counteract downstream consequences of insulin resistance. Inositol 10-18 insulin Homo sapiens 216-223 28070992-5 2017 Under the normal state, binding immunoglobulin protein (BiP) interacts with the three sensors (protein kinase RNA-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1alpha (IRE1alpha)). Inositol 183-191 heat shock protein family A (Hsp70) member 5 Homo sapiens 24-54 28070992-5 2017 Under the normal state, binding immunoglobulin protein (BiP) interacts with the three sensors (protein kinase RNA-like ER kinase (PERK), activating transcription factor 6 (ATF6), and inositol-requiring enzyme 1alpha (IRE1alpha)). Inositol 183-191 heat shock protein family A (Hsp70) member 5 Homo sapiens 56-59 31275022-2 2017 Inositol-requiring enzyme 1 (IRE1) is the most conserved sensor of the UPR with ribonuclease activity that mediates cytoplasmic splicing and decay of mRNA encoding secretory and membrane proteins. Inositol 0-8 ribonuclease Arabidopsis thaliana 80-92 27922641-6 2016 Inositol metabolites were differently affected by IMPA1 and SMIT1 knockout. Inositol 0-8 inositol (myo)-1(or 4)-monophosphatase 1 Mus musculus 50-55 27922641-6 2016 Inositol metabolites were differently affected by IMPA1 and SMIT1 knockout. Inositol 0-8 solute carrier family 5 (inositol transporters), member 3 Mus musculus 60-65 27658890-8 2016 Compared with placebo, myo-inositol intervention significantly reduced IL6 levels in BAL over 6 months (P = 0.03). Inositol 23-35 interleukin 6 Homo sapiens 71-74 27980366-6 2016 PTX3 production was significantly decreased in inositol-requiring enzyme 1alpha shRNA-transfected ARPE-19 cells compared to control shRNA-transfected cells. Inositol 47-55 pentraxin 3 Homo sapiens 0-4 27980366-11 2016 Inositol-requiring enzyme 1alpha and the NF-kappaB signaling pathway may serve as potential targets for regulation of PTX3 expression in the retina. Inositol 0-8 pentraxin 3 Homo sapiens 118-122 26650045-5 2016 However, reliable PLS-DA models can be developed between control and PD groups as well as between PD and bFGF groups, which is attributed to changes in a series of metabolites including GABA, glutamate (Glu), glutamine (Gln), lactate, N-acetylaspartate, creatine, taurine, and myo-inositol. Inositol 277-289 fibroblast growth factor 2 Rattus norvegicus 105-109 27717596-4 2016 As metformin often induces side effects, new integrative strategies have been proposed to treat insulin resistance, such as the use of inositols. Inositol 135-144 insulin Homo sapiens 96-103 27717596-7 2016 DCI derives from the conversion of myo-inositol via an insulin-dependent pathway. Inositol 35-47 insulin Homo sapiens 55-62 27725157-5 2016 This MVB formation was influenced by inhibition of ER stress transducers inositol required enzyme 1 (IRE1) and PKR-like ER kinase (PERK). Inositol 73-81 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 101-105 27801783-7 2016 Two inhibitors, namely salubrinal (Sal) and SP600125, partially abrogated 11-epi-SA-related cell death, implying that the protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK)-activating transcription factor (ATF) 6-CHOP or the inositol-requiring enzyme 1 alpha (IRE1alpha)-c-Jun N-terminal kinase (JNK)-cJun signal pathway was activated after 11-epi-SA treatment. Inositol 238-246 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 180-225 27410479-0 2016 Synthesis and biological activities of d-chiro-inositol analogues with insulin-like actions. Inositol 39-55 insulin Homo sapiens 71-78 27410479-1 2016 d-chiro-inositol (DCI, 1) evokes therapeutic actions in diabetes and insulin resistance but has sub-optimal pharmacokinetic profiles. Inositol 0-16 insulin Homo sapiens 69-76 27722727-2 2016 The crystal structure of SSA-1 involved two silicate layers composed of bre [10T]-type CBU (Composite Building Unit) and TEAOH in interlayers. Inositol 87-90 tripartite motif containing 21 Homo sapiens 25-30 27708385-7 2016 Thus, Bst1 can facilitate cell wall anchorage of GPI-APs in C. albicans by inositol deacylation, and is critical for host invasion and immune escape. Inositol 75-83 bone marrow stromal cell antigen 1 Mus musculus 6-10 27255472-1 2016 BACKGROUND: Myoinositol and D-chiroinositol improve insulin resistance in women with obesity and gestational diabetes and in postmenopausal women with metabolic syndrome. Inositol 12-23 insulin Homo sapiens 52-59 27255472-14 2016 Leptin serum levels were lower in the metabolic-like syndrome-myoinositol/D-chiroinositol-treated mice compared with the placebo group (myoinositol/D-chiroinositol: 16985 +- 976.4 pg/dL vs placebo: 24181.9 +- 3128.2 pg/dL, P = .045). Inositol 62-73 leptin Mus musculus 0-6 27255472-14 2016 Leptin serum levels were lower in the metabolic-like syndrome-myoinositol/D-chiroinositol-treated mice compared with the placebo group (myoinositol/D-chiroinositol: 16985 +- 976.4 pg/dL vs placebo: 24181.9 +- 3128.2 pg/dL, P = .045). Inositol 136-147 leptin Mus musculus 0-6 27255472-18 2016 CONCLUSION: Combined inositol treatment during pregnancy improves blood pressure, glucose levels at the glucose tolerance test, and leptin levels in pregnant dams with metabolic-like syndrome phenotype but not in obese pregnant dams. Inositol 21-29 leptin Mus musculus 132-138 27794380-14 2016 The expression of Cx43 in the cardiac muscular tissue in MI group was significantly decreased (P < 0.01 vs SO group). Inositol 57-59 gap junction protein, alpha 1 Rattus norvegicus 18-22 27028341-0 2016 Pioglitazone Therapy Increases Insulin-Stimulated Release of d-Chiro-Inositol-Containing Inositolphosphoglycan Mediator in Women with Polycystic Ovary Syndrome. Inositol 61-77 insulin Homo sapiens 31-38 26754953-10 2016 Plasma and CSF CRP were also associated with CSI measures of basal ganglia glutamate and the glial marker myoinositol. Inositol 106-117 C-reactive protein Homo sapiens 15-18 27578623-1 2016 The inositol requiring enzyme (IRE1) is an endoplasmic reticulum (ER) stress sensor. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 31-35 27212205-0 2016 Hypoglycemic effect of D-chiro-inositol in type 2 diabetes mellitus rats through the PI3K/Akt signaling pathway. Inositol 23-39 AKT serine/threonine kinase 1 Rattus norvegicus 90-93 27212205-2 2016 D-chiro-inositol (DCI) was administrated to the diabetic rats as two doses [30, 60 mg/(kg body weight day)]. Inositol 0-16 enoyl-CoA delta isomerase 1 Rattus norvegicus 18-21 27212269-2 2016 Biochemical studies indicate that the transduction mechanism at ORNs is mediated by cyclic adenosine monophosphate (cAMP) and/or inositol,1,4,5-triphosphate (InsP3)-signaling pathways in an odorant-dependent manner. Inositol 129-137 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 158-163 27444324-2 2016 Coexpression of the native ppMIOX and the urinate dehydrogenase (Udh) from Pseudomonas putida KT2440 led to obvious accumulation of glucaric acid (90.46+-0.04mg/L) from myo-inositol whereas no glucaric acid was detected from glucose. Inositol 169-181 NAD(P)-dependent oxidoreductase Pseudomonas putida KT2440 42-63 27444324-2 2016 Coexpression of the native ppMIOX and the urinate dehydrogenase (Udh) from Pseudomonas putida KT2440 led to obvious accumulation of glucaric acid (90.46+-0.04mg/L) from myo-inositol whereas no glucaric acid was detected from glucose. Inositol 169-181 NAD(P)-dependent oxidoreductase Pseudomonas putida KT2440 65-68 27444324-3 2016 In comparison, coexpression of the heterologous mouse MIOX (mMIOX) and Udh resulted in higher titers of glucaric acid from glucose and myo-inositol, 107.19+-11.91mg/L and 785.4+-1.41mg/L, respectively. Inositol 135-147 myo-inositol oxygenase Mus musculus 54-58 27444324-3 2016 In comparison, coexpression of the heterologous mouse MIOX (mMIOX) and Udh resulted in higher titers of glucaric acid from glucose and myo-inositol, 107.19+-11.91mg/L and 785.4+-1.41mg/L, respectively. Inositol 135-147 myo-inositol oxygenase Mus musculus 60-65 27444324-3 2016 In comparison, coexpression of the heterologous mouse MIOX (mMIOX) and Udh resulted in higher titers of glucaric acid from glucose and myo-inositol, 107.19+-11.91mg/L and 785.4+-1.41mg/L, respectively. Inositol 135-147 NAD(P)-dependent oxidoreductase Pseudomonas putida KT2440 71-74 27595157-6 2016 Inositol deficiency and the impairment of the inositol-dependent pathways may play an important role in the pathogenesis of insulin resistance and hypothyroidism. Inositol 0-8 insulin Homo sapiens 124-131 27595157-6 2016 Inositol deficiency and the impairment of the inositol-dependent pathways may play an important role in the pathogenesis of insulin resistance and hypothyroidism. Inositol 46-54 insulin Homo sapiens 124-131 26823555-5 2016 In cultured renal epithelial cells, ER stress specifically induced angiogenin secretion under the selective control of inositol-requiring enzyme 1alpha, a key activator of the unfolded protein response. Inositol 119-127 angiogenin Homo sapiens 67-77 26823555-6 2016 The transcription factors spliced X-box-binding protein 1 and p65, which are activated by inositol-requiring enzyme 1alpha upon ER stress, each bound the angiogenin promoter and controlled the amount of angiogenin secreted. Inositol 90-98 X-box binding protein 1 Homo sapiens 34-57 26823555-6 2016 The transcription factors spliced X-box-binding protein 1 and p65, which are activated by inositol-requiring enzyme 1alpha upon ER stress, each bound the angiogenin promoter and controlled the amount of angiogenin secreted. Inositol 90-98 golgi reassembly stacking protein 1 Homo sapiens 62-65 26823555-6 2016 The transcription factors spliced X-box-binding protein 1 and p65, which are activated by inositol-requiring enzyme 1alpha upon ER stress, each bound the angiogenin promoter and controlled the amount of angiogenin secreted. Inositol 90-98 angiogenin Homo sapiens 154-164 26823555-6 2016 The transcription factors spliced X-box-binding protein 1 and p65, which are activated by inositol-requiring enzyme 1alpha upon ER stress, each bound the angiogenin promoter and controlled the amount of angiogenin secreted. Inositol 90-98 angiogenin Homo sapiens 203-213 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Inositol 142-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 160-175 27009527-1 2016 The purpose of this study was to improve the efficiency of enzymatic synthesis of phosphatidylinositol (PI) from phosphatidylcholine (PC) and myo-inositol in a phospholipase D (PLD)-mediated transphosphatidylation. Inositol 142-154 glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens 177-180 27562249-9 2016 Furthermore, AICAR inhibited autophosphorylation of the ER stress sensor inositol-requiring enzyme 1alpha (IRE1alpha), while activating its endoribonuclease activity in vitro. Inositol 73-81 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase Homo sapiens 13-18 27562249-9 2016 Furthermore, AICAR inhibited autophosphorylation of the ER stress sensor inositol-requiring enzyme 1alpha (IRE1alpha), while activating its endoribonuclease activity in vitro. Inositol 73-81 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 107-116 27486476-7 2016 Furthermore, IFNgamma was found to trigger endoplasmic reticulum (ER) stress as evidenced by the cleavage of caspase-4 and activation of protein kinase RNA-like endoplasmic reticulum kinase (PERK) and inositol-requiring-1alpha (IRE1alpha) pathways. Inositol 201-209 interferon gamma Homo sapiens 13-21 27279487-2 2016 We have previously shown that inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells. Inositol 30-38 adenosylhomocysteinase like 1 Homo sapiens 128-133 27279487-2 2016 We have previously shown that inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells. Inositol 30-38 angiogenin Homo sapiens 144-147 27279487-2 2016 We have previously shown that inositol 1,4,5-trisphosphate receptor-binding protein released with inositol 1,4,5-trisphosphate (IRBIT) mediates ANG II-induced exocytosis of NHE3 in cultured proximal tubule epithelial cells. Inositol 30-38 solute carrier family 9 member A3 Homo sapiens 173-177 27186946-9 2016 Mechanistic studies revealed that the beneficial effects of GK occurred through enhancement of inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein-1 (XBP1) activity, which in turn led to increased ER-associated degradation-mediated clearance of misfolded proteins and autophagy. Inositol 95-103 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 129-138 27186946-9 2016 Mechanistic studies revealed that the beneficial effects of GK occurred through enhancement of inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein-1 (XBP1) activity, which in turn led to increased ER-associated degradation-mediated clearance of misfolded proteins and autophagy. Inositol 95-103 X-box binding protein 1 Mus musculus 140-163 27186946-9 2016 Mechanistic studies revealed that the beneficial effects of GK occurred through enhancement of inositol-requiring enzyme 1alpha (IRE1alpha)/X box-binding protein-1 (XBP1) activity, which in turn led to increased ER-associated degradation-mediated clearance of misfolded proteins and autophagy. Inositol 95-103 X-box binding protein 1 Mus musculus 165-169 27193581-12 2016 We demonstrate that latonduine triggers correction by regulating the activity of the unfolded protein response activator inositol-requiring enzyme (IRE-1) via modulation of the level of its ribosylation by PARP-16. Inositol 121-129 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 148-153 27193581-12 2016 We demonstrate that latonduine triggers correction by regulating the activity of the unfolded protein response activator inositol-requiring enzyme (IRE-1) via modulation of the level of its ribosylation by PARP-16. Inositol 121-129 poly(ADP-ribose) polymerase family member 16 Homo sapiens 206-213 27384111-4 2016 In addition, by using primary human islets, mouse islets, and INS-1 beta-cells, we found that miR-204 decreased PERK expression as well as its downstream factors, activating transcription factor 4 and CCAAT enhancer-binding protein homologous protein, whereas it had no effect on the other 2 ER transmembrane sensors, activating transcription factor 6 and inositol-requiring enzyme-1alpha. Inositol 356-364 insulin 1 Rattus norvegicus 62-67 27384111-4 2016 In addition, by using primary human islets, mouse islets, and INS-1 beta-cells, we found that miR-204 decreased PERK expression as well as its downstream factors, activating transcription factor 4 and CCAAT enhancer-binding protein homologous protein, whereas it had no effect on the other 2 ER transmembrane sensors, activating transcription factor 6 and inositol-requiring enzyme-1alpha. Inositol 356-364 microRNA 204 Rattus norvegicus 94-101 27384111-4 2016 In addition, by using primary human islets, mouse islets, and INS-1 beta-cells, we found that miR-204 decreased PERK expression as well as its downstream factors, activating transcription factor 4 and CCAAT enhancer-binding protein homologous protein, whereas it had no effect on the other 2 ER transmembrane sensors, activating transcription factor 6 and inositol-requiring enzyme-1alpha. Inositol 356-364 eukaryotic translation initiation factor 2 alpha kinase 3 Homo sapiens 112-116 27384111-4 2016 In addition, by using primary human islets, mouse islets, and INS-1 beta-cells, we found that miR-204 decreased PERK expression as well as its downstream factors, activating transcription factor 4 and CCAAT enhancer-binding protein homologous protein, whereas it had no effect on the other 2 ER transmembrane sensors, activating transcription factor 6 and inositol-requiring enzyme-1alpha. Inositol 356-364 activating transcription factor 4 Rattus norvegicus 163-196 27558934-0 2016 Knockout of inositol-requiring enzyme 1alpha in pro-opiomelanocortin neurons decreases fat mass via increasing energy expenditure. Inositol 12-20 pro-opiomelanocortin-alpha Mus musculus 48-68 27558934-1 2016 Although numerous functions of inositol-requiring enzyme 1alpha (IRE1alpha) have been identified, a role of IRE1alpha in pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus is largely unknown. Inositol 31-39 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 65-74 27059130-2 2016 Inositol-requiring enzyme 1alpha (IRE1alpha) and its downstream molecule X-box binding protein 1 (XBP1) play key roles in the ER-related apoptosis pathway. Inositol 0-8 X-box binding protein 1 Rattus norvegicus 73-96 27059130-2 2016 Inositol-requiring enzyme 1alpha (IRE1alpha) and its downstream molecule X-box binding protein 1 (XBP1) play key roles in the ER-related apoptosis pathway. Inositol 0-8 X-box binding protein 1 Rattus norvegicus 98-102 27282535-2 2016 Crystallization profiles of myo-inositol and its mixture with dextran 40k in frozen solutions and dried solids were assessed by thermal analysis (DSC), powder-X-ray diffraction, and simultaneous DSC and PXRD analysis. Inositol 28-40 desmocollin 3 Homo sapiens 146-149 27282535-2 2016 Crystallization profiles of myo-inositol and its mixture with dextran 40k in frozen solutions and dried solids were assessed by thermal analysis (DSC), powder-X-ray diffraction, and simultaneous DSC and PXRD analysis. Inositol 28-40 desmocollin 3 Homo sapiens 195-198 27013634-2 2016 SOCE attributable to inositol 1,4,5-trisphosphate receptor (InsP3R)-gated Ca(2+) store has been studied extensively, but the role of ryanodine receptor (RyR)-gated store in SOCE remains unclear. Inositol 21-29 inositol 1,4,5-trisphosphate receptor, type 1 Rattus norvegicus 60-66 27237097-2 2016 As Akt activation is inhibited by inositol, we investigated if such effect could hamper EMT in MDA-MB-231 breast cancer cells. Inositol 34-42 AKT serine/threonine kinase 1 Homo sapiens 3-6 27237097-5 2016 Inositol-mediated inhibition of PS1 leads to lowered Notch 1 release, thus contributing in decreasing SNAI1 levels. Inositol 0-8 taste 2 receptor member 62 pseudogene Homo sapiens 32-35 27237097-5 2016 Inositol-mediated inhibition of PS1 leads to lowered Notch 1 release, thus contributing in decreasing SNAI1 levels. Inositol 0-8 notch receptor 1 Homo sapiens 53-60 27237097-5 2016 Inositol-mediated inhibition of PS1 leads to lowered Notch 1 release, thus contributing in decreasing SNAI1 levels. Inositol 0-8 snail family transcriptional repressor 1 Homo sapiens 102-107 27237097-9 2016 Inositol slowed-down vimentin expression in cells placed behind the wound-healing edge and stabilized cortical F-actin. Inositol 0-8 vimentin Homo sapiens 21-29 27022162-7 2016 The inhibition of inositol-requiring enzyme 1 significantly suppressed Nedd4-2 expression. Inositol 18-26 neural precursor cell expressed, developmentally down-regulated gene 4-like Mus musculus 71-78 27022162-8 2016 Moreover, increased Nedd4-2 expression in vivo was closely associated with the activation of inositol-requiring enzyme 1 and increased expression of the spliced form of X-box binding protein 1. Inositol 93-101 neural precursor cell expressed, developmentally down-regulated gene 4-like Mus musculus 20-27 27132146-8 2016 These results demonstrated that Xenopus oocytes or HEK293T cells expressing BmGr10 specifically respond to myo-inositol and epi-inositol but do not respond to any mono-, di-, or tri-saccharides or to some sugar alcohols. Inositol 107-119 candidate olfactory receptor Bombyx mori 76-82 27132146-8 2016 These results demonstrated that Xenopus oocytes or HEK293T cells expressing BmGr10 specifically respond to myo-inositol and epi-inositol but do not respond to any mono-, di-, or tri-saccharides or to some sugar alcohols. Inositol 124-136 candidate olfactory receptor Bombyx mori 76-82 27132146-10 2016 Overall, BmGr10 plays an important role in the myo-inositol recognition required for B. mori larval feeding behavior. Inositol 47-59 candidate olfactory receptor Bombyx mori 9-15 27294516-8 2016 In contrast to TASK-1, which was not differentially expressed in lung cancer vs. normal lung tissue, we found the Na+-coupled nutrient transporters, SLC5A3, SLC5A6, and SLC38A1, transporters for myo-inositol, biotin and glutamine, respectively, to be significantly overexpressed in lung adenocarcinomas. Inositol 195-207 solute carrier family 5 member 3 Homo sapiens 149-155 27294516-8 2016 In contrast to TASK-1, which was not differentially expressed in lung cancer vs. normal lung tissue, we found the Na+-coupled nutrient transporters, SLC5A3, SLC5A6, and SLC38A1, transporters for myo-inositol, biotin and glutamine, respectively, to be significantly overexpressed in lung adenocarcinomas. Inositol 195-207 solute carrier family 5 member 6 Homo sapiens 157-163 27294516-8 2016 In contrast to TASK-1, which was not differentially expressed in lung cancer vs. normal lung tissue, we found the Na+-coupled nutrient transporters, SLC5A3, SLC5A6, and SLC38A1, transporters for myo-inositol, biotin and glutamine, respectively, to be significantly overexpressed in lung adenocarcinomas. Inositol 195-207 solute carrier family 38 member 1 Homo sapiens 169-176 27217553-5 2016 We found that overexpression of the Na(+)/myo-inositol cotransporter (SMIT1) and myo-inositol supplementation enlarged intracellular PI(4,5)P2 pools, modulated several PI(4,5)P2-dependent ion channels including KCNQ2/3 channels, and attenuated the action potential firing of superior cervical ganglion neurons. Inositol 42-54 solute carrier family 5 member 3 Homo sapiens 70-75 27217553-5 2016 We found that overexpression of the Na(+)/myo-inositol cotransporter (SMIT1) and myo-inositol supplementation enlarged intracellular PI(4,5)P2 pools, modulated several PI(4,5)P2-dependent ion channels including KCNQ2/3 channels, and attenuated the action potential firing of superior cervical ganglion neurons. Inositol 42-54 potassium voltage-gated channel subfamily Q member 2 Homo sapiens 211-216 27256815-2 2016 The inositol requiring enzyme 1 (IRE1) signaling pathway activated by the IRE1-mediated unconventional splicing of HAC1 in yeast, bZIP60 in plants and XBP1 in metazoans, is the most ancient branch of the UPR. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 33-37 27256815-2 2016 The inositol requiring enzyme 1 (IRE1) signaling pathway activated by the IRE1-mediated unconventional splicing of HAC1 in yeast, bZIP60 in plants and XBP1 in metazoans, is the most ancient branch of the UPR. Inositol 4-12 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 74-78 27256815-2 2016 The inositol requiring enzyme 1 (IRE1) signaling pathway activated by the IRE1-mediated unconventional splicing of HAC1 in yeast, bZIP60 in plants and XBP1 in metazoans, is the most ancient branch of the UPR. Inositol 4-12 transcription factor HAC1 Saccharomyces cerevisiae S288C 115-119 27256815-2 2016 The inositol requiring enzyme 1 (IRE1) signaling pathway activated by the IRE1-mediated unconventional splicing of HAC1 in yeast, bZIP60 in plants and XBP1 in metazoans, is the most ancient branch of the UPR. Inositol 4-12 Xbp1p Saccharomyces cerevisiae S288C 151-155 26948394-0 2016 A pilot study of gestational diabetes mellitus not controlled by diet alone: First-line medical treatment with myoinositol may limit the need for insulin. Inositol 111-122 insulin Homo sapiens 146-153 26948394-4 2016 RESULTS: Insulin was required in eight women (25%) in the myoinositol group who, compared with the 24 who did not need insulin, were older (37+-5 vs. 32+-5 years, respectively; P=0.018) and had a larger percentage of high self-monitored glucose values (45+-8% vs. 32+-14%; P<0.0001) during the week prior to the introduction of myoinositol treatment. Inositol 58-69 insulin Homo sapiens 9-16 26948394-4 2016 RESULTS: Insulin was required in eight women (25%) in the myoinositol group who, compared with the 24 who did not need insulin, were older (37+-5 vs. 32+-5 years, respectively; P=0.018) and had a larger percentage of high self-monitored glucose values (45+-8% vs. 32+-14%; P<0.0001) during the week prior to the introduction of myoinositol treatment. Inositol 331-342 insulin Homo sapiens 9-16 26927948-4 2016 Inositol is a polyalcohol, naturally occurring as nine stereoisomers, including D-chiro-inositol (DCI) and myo-inositol (MI), which have prominent roles in the metabolism of glucose and free fatty acids. Inositol 0-8 enoyl-CoA delta isomerase 1 Homo sapiens 98-101 26927948-4 2016 Inositol is a polyalcohol, naturally occurring as nine stereoisomers, including D-chiro-inositol (DCI) and myo-inositol (MI), which have prominent roles in the metabolism of glucose and free fatty acids. Inositol 80-96 enoyl-CoA delta isomerase 1 Homo sapiens 98-101 27035231-0 2016 Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway. Inositol 14-26 tumor protein p53 Homo sapiens 43-46 27035231-0 2016 Regulation of myo-inositol biosynthesis by p53-ISYNA1 pathway. Inositol 14-26 inositol-3-phosphate synthase 1 Homo sapiens 47-53 27035231-4 2016 Through a microarray screening, we found that five genes related with myo-inositol metabolism were induced by p53. Inositol 70-82 tumor protein p53 Homo sapiens 110-113 27035231-5 2016 DNA damage enhanced intracellular myo-inositol content in HCT116 p53+/+ cells, but not in HCT116 p53-/- cells. Inositol 34-46 tumor protein p53 Homo sapiens 65-68 27035231-6 2016 We also indicated that inositol 3-phosphate synthase (ISYNA1) which encodes an enzyme essential for myo-inositol biosynthesis as a direct target of p53. Inositol 100-112 inositol-3-phosphate synthase 1 Homo sapiens 54-60 27035231-6 2016 We also indicated that inositol 3-phosphate synthase (ISYNA1) which encodes an enzyme essential for myo-inositol biosynthesis as a direct target of p53. Inositol 100-112 tumor protein p53 Homo sapiens 148-151 27035231-8 2016 Ectopic ISYNA1 expression increased myo-inositol levels in the cells and suppressed tumor cell growth. Inositol 36-48 inositol-3-phosphate synthase 1 Homo sapiens 8-14 27035231-11 2016 Our findings revealed a novel role of p53 in myo-inositol biosynthesis which could be a potential therapeutic target. Inositol 45-57 tumor protein p53 Homo sapiens 38-41 27142131-1 2016 Inositol metabolism is severely impaired in follicles obtained from cystic ovaries, leading to deregulated insulin transduction and steroid synthesis. Inositol 0-8 insulin Homo sapiens 107-114 27142131-2 2016 On the contrary, inositol administration to women suffering from polycystic ovary syndrome (PCOS) has been proven to efficiently counteract most of the clinical hallmarks displayed by PCOS patients, including insulin resistance, hyperandrogenism and oligo-amenorrhea. Inositol 17-25 insulin Homo sapiens 209-216 27142131-4 2016 We hypothesize that inositol and its monophosphate derivatives, besides their effects on insulin transduction, may efficiently revert histological and functional features of cystic ovary by inducing cytoskeleton rearrangements. Inositol 20-28 insulin Homo sapiens 89-96 26953345-0 2016 Inositol Hexakisphosphate Kinase 1 (IP6K1) Regulates Inositol Synthesis in Mammalian Cells. Inositol 0-8 inositol hexakisphosphate kinase 1 Homo sapiens 36-41 26953345-3 2016 In this study, we report that IP6K1, an inositol hexakisphosphate kinase that catalyzes the synthesis of inositol pyrophosphate, regulates inositol synthesis in mammalian cells. Inositol 40-48 inositol hexakisphosphate kinase 1 Homo sapiens 30-35 26953345-6 2016 This is the first demonstration of IP6K1 as a novel negative regulator of inositol synthesis in mammalian cells. Inositol 74-82 inositol hexakisphosphate kinase 1 Homo sapiens 35-40 26968535-6 2016 Consequently, we developed a rapid multiparameter flow cytometric CBU potency assay that enumerates cells expressing high levels of the enzyme aldehyde dehydrogenase (ALDH bright [ALDH(br)]), along with viable CD45(+) or CD34(+) cell content. Inositol 66-69 protein tyrosine phosphatase receptor type C Homo sapiens 210-214 26968535-6 2016 Consequently, we developed a rapid multiparameter flow cytometric CBU potency assay that enumerates cells expressing high levels of the enzyme aldehyde dehydrogenase (ALDH bright [ALDH(br)]), along with viable CD45(+) or CD34(+) cell content. Inositol 66-69 CD34 molecule Homo sapiens 221-225 27164711-0 2016 Myo-inositol changes precede amyloid pathology and relate to APOE genotype in Alzheimer disease. Inositol 0-12 apolipoprotein E Homo sapiens 61-65 26951199-1 2016 Inositol levels, maintained by the biosynthetic enzyme inositol-3-phosphate synthase (Ino1), are altered in a range of disorders, including bipolar disorder and Alzheimer"s disease. Inositol 0-8 inositol-3-phosphate synthase 1 Homo sapiens 86-90 26951199-4 2016 We show that loss of Ino1 results in an inositol auxotrophy that can be rescued only partially by exogenous inositol. Inositol 40-48 inositol-3-phosphate synthase 1 Homo sapiens 21-25 26951199-4 2016 We show that loss of Ino1 results in an inositol auxotrophy that can be rescued only partially by exogenous inositol. Inositol 108-116 inositol-3-phosphate synthase 1 Homo sapiens 21-25 26951199-5 2016 Removal of inositol supplementation from the ino1(-) mutant resulted in a rapid 56% reduction in inositol levels, triggering the induction of autophagy, reduced cytokinesis, and substrate adhesion. Inositol 11-19 inositol-3-phosphate synthase 1 Homo sapiens 45-49 26951199-5 2016 Removal of inositol supplementation from the ino1(-) mutant resulted in a rapid 56% reduction in inositol levels, triggering the induction of autophagy, reduced cytokinesis, and substrate adhesion. Inositol 97-105 inositol-3-phosphate synthase 1 Homo sapiens 45-49 26899404-5 2016 A key component of the UPR is the ER transmembrane protein IRE1alpha (inositol-requiring enzyme 1alpha). Inositol 70-78 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 59-68 26858253-6 2016 In contrast, IFNgamma increased pro-apoptotic TXNIP post-transcriptionally via induction of endoplasmic reticulum stress, activation of inositol-requiring enzyme 1alpha (IRE1alpha), and suppression of miR-17, a microRNA that targets and down-regulates TXNIP. Inositol 136-144 interferon gamma Homo sapiens 13-21 26858253-6 2016 In contrast, IFNgamma increased pro-apoptotic TXNIP post-transcriptionally via induction of endoplasmic reticulum stress, activation of inositol-requiring enzyme 1alpha (IRE1alpha), and suppression of miR-17, a microRNA that targets and down-regulates TXNIP. Inositol 136-144 thioredoxin interacting protein Homo sapiens 46-51 27148278-3 2016 This work reveals the involvement of inositol-3-phosphate synthase 1 (IPS1), a key enzyme for biosynthesis of myo-inositol and its derivatives, in the response to NO-dependent OS in Arabidopsis. Inositol 110-122 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 37-68 27148278-3 2016 This work reveals the involvement of inositol-3-phosphate synthase 1 (IPS1), a key enzyme for biosynthesis of myo-inositol and its derivatives, in the response to NO-dependent OS in Arabidopsis. Inositol 110-122 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 70-74 26714049-0 2016 Arabidopsis FHY3 and FAR1 Regulate Light-Induced myo-Inositol Biosynthesis and Oxidative Stress Responses by Transcriptional Activation of MIPS1. Inositol 49-61 far-red elongated hypocotyls 3 Arabidopsis thaliana 12-16 26714049-0 2016 Arabidopsis FHY3 and FAR1 Regulate Light-Induced myo-Inositol Biosynthesis and Oxidative Stress Responses by Transcriptional Activation of MIPS1. Inositol 49-61 FRS (FAR1 Related Sequences) transcription factor family Arabidopsis thaliana 21-25 26714049-0 2016 Arabidopsis FHY3 and FAR1 Regulate Light-Induced myo-Inositol Biosynthesis and Oxidative Stress Responses by Transcriptional Activation of MIPS1. Inositol 49-61 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 139-144 26714049-2 2016 In response to stress, the transcription of MIPS1 is induced and the biosynthesis of inositol or inositol derivatives is promoted by unknown mechanisms. Inositol 85-93 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 44-49 26714049-2 2016 In response to stress, the transcription of MIPS1 is induced and the biosynthesis of inositol or inositol derivatives is promoted by unknown mechanisms. Inositol 97-105 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 44-49 26714049-3 2016 Here, we found that the light signaling protein FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and its homolog FAR-RED IMPAIRED RESPONSE1 (FAR1) regulate light-induced inositol biosynthesis and oxidative stress responses by activating the transcription of MIPS1. Inositol 157-165 far-red elongated hypocotyls 3 Arabidopsis thaliana 48-76 26714049-3 2016 Here, we found that the light signaling protein FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and its homolog FAR-RED IMPAIRED RESPONSE1 (FAR1) regulate light-induced inositol biosynthesis and oxidative stress responses by activating the transcription of MIPS1. Inositol 157-165 far-red elongated hypocotyls 3 Arabidopsis thaliana 78-82 26714049-3 2016 Here, we found that the light signaling protein FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and its homolog FAR-RED IMPAIRED RESPONSE1 (FAR1) regulate light-induced inositol biosynthesis and oxidative stress responses by activating the transcription of MIPS1. Inositol 157-165 FRS (FAR1 Related Sequences) transcription factor family Arabidopsis thaliana 100-126 26714049-3 2016 Here, we found that the light signaling protein FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and its homolog FAR-RED IMPAIRED RESPONSE1 (FAR1) regulate light-induced inositol biosynthesis and oxidative stress responses by activating the transcription of MIPS1. Inositol 157-165 FRS (FAR1 Related Sequences) transcription factor family Arabidopsis thaliana 128-132 26714049-3 2016 Here, we found that the light signaling protein FAR-RED ELONGATED HYPOCOTYL3 (FHY3) and its homolog FAR-RED IMPAIRED RESPONSE1 (FAR1) regulate light-induced inositol biosynthesis and oxidative stress responses by activating the transcription of MIPS1. Inositol 157-165 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 245-250 26714049-7 2016 The fhy3 far1 mutant plants showed severely decreased MIPS1/2 transcript levels and reduced inositol levels. Inositol 92-100 far-red elongated hypocotyls 3 Arabidopsis thaliana 4-8 26714049-7 2016 The fhy3 far1 mutant plants showed severely decreased MIPS1/2 transcript levels and reduced inositol levels. Inositol 92-100 FRS (FAR1 Related Sequences) transcription factor family Arabidopsis thaliana 9-13 26714049-8 2016 Conversely, constitutive expression of MIPS1 partially rescued the inositol contents, caused reduced transcript levels of SA-biosynthesis genes, and prevented oxidative stress in fhy3 far1. Inositol 67-75 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 39-44 26714049-9 2016 Taken together, our results indicate that the light signaling proteins FHY3 and FAR1 directly bind the promoter of MIPS1 to activate its expression and thereby promote inositol biosynthesis to prevent light-induced oxidative stress and SA-dependent cell death. Inositol 168-176 far-red elongated hypocotyls 3 Arabidopsis thaliana 71-75 26714049-9 2016 Taken together, our results indicate that the light signaling proteins FHY3 and FAR1 directly bind the promoter of MIPS1 to activate its expression and thereby promote inositol biosynthesis to prevent light-induced oxidative stress and SA-dependent cell death. Inositol 168-176 FRS (FAR1 Related Sequences) transcription factor family Arabidopsis thaliana 80-84 26714049-9 2016 Taken together, our results indicate that the light signaling proteins FHY3 and FAR1 directly bind the promoter of MIPS1 to activate its expression and thereby promote inositol biosynthesis to prevent light-induced oxidative stress and SA-dependent cell death. Inositol 168-176 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 115-120 26678450-6 2016 amazonensisactivates the inositol-requiring enzyme (IRE1)/ X-box binding protein (XBP)-1-splicing arms of the IERSR in host cells. Inositol 25-33 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 52-56 26678450-6 2016 amazonensisactivates the inositol-requiring enzyme (IRE1)/ X-box binding protein (XBP)-1-splicing arms of the IERSR in host cells. Inositol 25-33 activating transcription factor 2 Mus musculus 59-80 26678450-6 2016 amazonensisactivates the inositol-requiring enzyme (IRE1)/ X-box binding protein (XBP)-1-splicing arms of the IERSR in host cells. Inositol 25-33 activating transcription factor 2 Mus musculus 82-85 26344121-8 2016 Our results show that simultaneous deletion of LEU4 and LEU9 (leading to accumulation of valine) or INM1 and INM2 (leading to reduction of inositol) significantly enhanced ethanol tolerance. Inositol 139-147 2-isopropylmalate synthase LEU4 Saccharomyces cerevisiae S288C 47-51 26344121-8 2016 Our results show that simultaneous deletion of LEU4 and LEU9 (leading to accumulation of valine) or INM1 and INM2 (leading to reduction of inositol) significantly enhanced ethanol tolerance. Inositol 139-147 2-isopropylmalate synthase LEU9 Saccharomyces cerevisiae S288C 56-60 26344121-8 2016 Our results show that simultaneous deletion of LEU4 and LEU9 (leading to accumulation of valine) or INM1 and INM2 (leading to reduction of inositol) significantly enhanced ethanol tolerance. Inositol 139-147 inositol monophosphate 1-phosphatase INM1 Saccharomyces cerevisiae S288C 100-104 26344121-8 2016 Our results show that simultaneous deletion of LEU4 and LEU9 (leading to accumulation of valine) or INM1 and INM2 (leading to reduction of inositol) significantly enhanced ethanol tolerance. Inositol 139-147 inositol monophosphate 1-phosphatase INM2 Saccharomyces cerevisiae S288C 109-113 26711306-3 2016 The hepatic I/R injury, demonstrated by serum aminotransferase level and the ultra-structure of the liver, was alleviated by administration of tunicamycin, which induced ER stress in rat liver by activating inositol-requiring enzyme 1 (IRE1) and upregulating 78 kDa glucose-regulated protein (GRP78). Inositol 207-215 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 236-240 26792859-5 2016 myo-Inositol oxygenase (MIOX) is a tubular enzyme that catabolizes myo-inositol to d-glucuronate via the glucuronate-xylulose (G-X) pathway. Inositol 67-79 inositol oxygenase Sus scrofa 0-22 26792859-5 2016 myo-Inositol oxygenase (MIOX) is a tubular enzyme that catabolizes myo-inositol to d-glucuronate via the glucuronate-xylulose (G-X) pathway. Inositol 67-79 inositol oxygenase Sus scrofa 24-28 26965057-3 2016 The enzyme transfers a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to 2-position of inositol in PIM1/PIM2. Inositol 121-129 Pim-1 proto-oncogene, serine/threonine kinase Homo sapiens 133-137 26965057-3 2016 The enzyme transfers a palmitoyl moiety from palmitoyl-CoA to the 6-position of the mannose ring linked to 2-position of inositol in PIM1/PIM2. Inositol 121-129 Pim-2 proto-oncogene, serine/threonine kinase Homo sapiens 138-142 26692031-0 2016 BRET-monitoring of the dynamic changes of inositol lipid pools in living cells reveals a PKC-dependent PtdIns4P increase upon EGF and M3 receptor activation. Inositol 42-50 epidermal growth factor Homo sapiens 126-129 26853145-4 2016 The MLKL brace, proximal to the N-terminal helix bundle (NB), is involved in oligomerization to facilitate plasma membrane targeting through the low-affinity binding of NB to phosphorylated inositol polar head groups of phosphatidylinositol phosphate (PIP) phospholipids. Inositol 190-198 mixed lineage kinase domain like pseudokinase Homo sapiens 4-8 26573878-5 2016 Furthermore, TSLP secretion is significantly increased by signals emanating from the endoplasmic reticulum (ER) stress response, specifically the unfolded protein response sensors, inositol-requiring transmembrane kinase/endonuclease 1 and protein kinase R-like ER kinase, which are activated by dectin-1 stimulation. Inositol 181-189 thymic stromal lymphopoietin Homo sapiens 13-17 26621917-8 2016 Because PA activates ER stress, we used KO hepatocytes to demonstrate that PA-induced EV release was mediated by inositol requiring enzyme 1alpha (IRE1alpha)/X-box binding protein-1. Inositol 113-121 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 147-156 26621917-8 2016 Because PA activates ER stress, we used KO hepatocytes to demonstrate that PA-induced EV release was mediated by inositol requiring enzyme 1alpha (IRE1alpha)/X-box binding protein-1. Inositol 113-121 X-box binding protein 1 Homo sapiens 158-181 26753564-10 2016 We also found that PlGF expression is upregulated by different chemical UPR inducers via activation of the inositol-requiring enzyme 1 pathway in HCC cells. Inositol 107-115 placental growth factor Mus musculus 19-23 27642592-7 2016 The number of neuronal cells in CA1 and CA3 subfields of hippocampus is decreased after KA induced SE and MI posttreatment significantly attenuates this reduction. Inositol 106-108 carbonic anhydrase 1 Rattus norvegicus 32-35 27642592-7 2016 The number of neuronal cells in CA1 and CA3 subfields of hippocampus is decreased after KA induced SE and MI posttreatment significantly attenuates this reduction. Inositol 106-108 carbonic anhydrase 3 Rattus norvegicus 40-43 26337904-2 2016 The subsequent unfolded protein response (UPR) interacts with insulin signaling through inositol-requiring 1alpha (IRE1alpha) activation and tribbles homolog 3 (TRB3) expressions. Inositol 88-96 insulin Homo sapiens 62-69 26910807-2 2016 Inositol-requiring enzyme 1alpha (IRE1alpha) is the most sensitive of the three unfolded protein response (UPR) branches which are triggered to cope with ER stress in mammalian cells. Inositol 0-8 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 34-43 29537195-2 2016 Inhibition of ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1/inositol requiring enzyme 1), a central mediator of endoplasmic reticulum stress, significantly suppresses glioma cell proliferation and tumor growth as well as modifies sensitivity gene expressions to glucose and glutamine deprivation. Inositol 70-78 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 14-18 29537195-2 2016 Inhibition of ERN1/IRE1 (endoplasmic reticulum to nucleus signaling 1/inositol requiring enzyme 1), a central mediator of endoplasmic reticulum stress, significantly suppresses glioma cell proliferation and tumor growth as well as modifies sensitivity gene expressions to glucose and glutamine deprivation. Inositol 70-78 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 19-23 27493664-0 2016 A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. Inositol 24-36 insulin Homo sapiens 92-99 27493664-0 2016 A Combined Therapy with Myo-Inositol and D-Chiro-Inositol Improves Endocrine Parameters and Insulin Resistance in PCOS Young Overweight Women. Inositol 41-57 insulin Homo sapiens 92-99 27579037-3 2016 Myo (MI) and D-chiro-inositol (DCI), the most studied inositol isoforms, are classified as insulin sensitizers. Inositol 13-29 insulin Homo sapiens 91-98 27579037-3 2016 Myo (MI) and D-chiro-inositol (DCI), the most studied inositol isoforms, are classified as insulin sensitizers. Inositol 21-29 insulin Homo sapiens 91-98 27688754-0 2016 Inositols in the Treatment of Insulin-Mediated Diseases. Inositol 0-9 insulin Homo sapiens 30-37 27688754-1 2016 A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Inositol 63-71 insulin Homo sapiens 167-174 27688754-1 2016 A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Inositol 98-110 insulin Homo sapiens 167-174 27688754-1 2016 A growing body of research is currently focused on the role of inositol isomers and in particular myo-inositol (MYO-INS) and D-chiroinositol (DCI) in the treatment of insulin resistance states. Inositol 112-119 insulin Homo sapiens 167-174 27688754-3 2016 Further, insulin resistance-related diseases were associated to derangements in inositol metabolism. Inositol 80-88 insulin Homo sapiens 9-16 27688754-4 2016 Thus, the aim of this review is to provide current evidence on the potential benefits of inositol isomers (MYO-INS and DCI) in the treatment of disease associated to insulin resistance such as polycystic ovary syndrome (PCOS), gestational diabetes, and metabolic syndrome. Inositol 89-97 insulin Homo sapiens 166-173 27688754-5 2016 Finally, molecular insights into inositol insulin-sensitizing effects will be covered focusing on the possible role of inositol glycans as insulin second messengers. Inositol 33-41 insulin Homo sapiens 42-49 27721826-0 2016 Effect on Insulin-Stimulated Release of D-Chiro-Inositol-Containing Inositolphosphoglycan Mediator during Weight Loss in Obese Women with and without Polycystic Ovary Syndrome. Inositol 40-56 insulin Homo sapiens 10-17 27795706-4 2016 Insulin-sensitizing compounds such as inositol, a B-complex vitamin, and its stereoisomers (myo-inositol and D-chiro-inositol) have been studied as an effective treatment of PCOS. Inositol 38-46 insulin Homo sapiens 0-7 27795706-4 2016 Insulin-sensitizing compounds such as inositol, a B-complex vitamin, and its stereoisomers (myo-inositol and D-chiro-inositol) have been studied as an effective treatment of PCOS. Inositol 92-104 insulin Homo sapiens 0-7 27795706-4 2016 Insulin-sensitizing compounds such as inositol, a B-complex vitamin, and its stereoisomers (myo-inositol and D-chiro-inositol) have been studied as an effective treatment of PCOS. Inositol 109-125 insulin Homo sapiens 0-7 27795708-6 2016 Additionally, Akt activation is severely impaired upon inositol addition. Inositol 55-63 AKT serine/threonine kinase 1 Homo sapiens 14-17 27795708-8 2016 Remarkably, inositol-induced downregulation of presenilin-1 interferes with the epithelial-mesenchymal transition and reduces Wnt-activation, beta-catenin translocation, Notch-1, N-cadherin, and SNAI1 release. Inositol 12-20 presenilin 1 Homo sapiens 47-59 27795708-8 2016 Remarkably, inositol-induced downregulation of presenilin-1 interferes with the epithelial-mesenchymal transition and reduces Wnt-activation, beta-catenin translocation, Notch-1, N-cadherin, and SNAI1 release. Inositol 12-20 catenin beta 1 Homo sapiens 142-154 27795708-8 2016 Remarkably, inositol-induced downregulation of presenilin-1 interferes with the epithelial-mesenchymal transition and reduces Wnt-activation, beta-catenin translocation, Notch-1, N-cadherin, and SNAI1 release. Inositol 12-20 notch receptor 1 Homo sapiens 170-177 27795708-8 2016 Remarkably, inositol-induced downregulation of presenilin-1 interferes with the epithelial-mesenchymal transition and reduces Wnt-activation, beta-catenin translocation, Notch-1, N-cadherin, and SNAI1 release. Inositol 12-20 cadherin 2 Homo sapiens 179-189 27795708-8 2016 Remarkably, inositol-induced downregulation of presenilin-1 interferes with the epithelial-mesenchymal transition and reduces Wnt-activation, beta-catenin translocation, Notch-1, N-cadherin, and SNAI1 release. Inositol 12-20 snail family transcriptional repressor 1 Homo sapiens 195-200 27795708-10 2016 This effect is reinforced by the inositol-induced inhibition on metalloproteinases and ROCK1/2 release. Inositol 33-41 Rho associated coiled-coil containing protein kinase 1 Homo sapiens 87-92 27807448-2 2016 Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Inositol 5-17 insulin Homo sapiens 57-64 27807448-2 2016 Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Inositol 5-17 insulin Homo sapiens 98-105 27807448-2 2016 Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Inositol 33-49 insulin Homo sapiens 57-64 27807448-2 2016 Both myo-inositol and its isomer d-chiro-inositol showed insulin mimetic effects in conditions of insulin resistance. Inositol 33-49 insulin Homo sapiens 98-105 27882052-0 2016 Myoinositol and D-Chiro Inositol in Improving Insulin Resistance in Obese Male Children: Preliminary Data. Inositol 0-11 insulin Homo sapiens 46-53 27882052-1 2016 Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. Inositol 0-11 insulin Homo sapiens 89-96 27882052-1 2016 Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. Inositol 0-11 insulin Homo sapiens 131-138 27882052-1 2016 Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. Inositol 3-11 insulin Homo sapiens 89-96 27882052-1 2016 Myoinositol and D-chiro inositol, which are inositol isomers, have been shown to possess insulin-mimetic properties and to improve insulin resistance, especially in women with polycystic ovary syndrome. Inositol 3-11 insulin Homo sapiens 131-138 27882052-3 2016 Based on these previous findings, we hypothesized that inositol could be effective in improving insulin sensitivity in children with insulin resistance. Inositol 55-63 insulin Homo sapiens 96-103 27882052-3 2016 Based on these previous findings, we hypothesized that inositol could be effective in improving insulin sensitivity in children with insulin resistance. Inositol 55-63 insulin Homo sapiens 133-140 27882052-5 2016 Our results confirm that myoinositol and D-chiro inositol acutely reduce insulin increase after glucose intake mainly in children with high basal insulin level. Inositol 25-36 insulin Homo sapiens 73-80 28044078-0 2016 Erratum to "Inositols in the Treatment of Insulin-Mediated Diseases". Inositol 12-21 insulin Homo sapiens 42-49 26552689-3 2016 The synthesis of phosphatidylinositol requires the activity of an enzyme called phosphatidylinositol synthase, also known as CDIPT, which catalyzes a reversible headgroup exchange reaction on its substrate liponucleotide CDP-diacylglycerol resulting in the incorporation of inositol to generate phosphatidylinositol and the release of CMP. Inositol 29-37 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 80-109 26552689-3 2016 The synthesis of phosphatidylinositol requires the activity of an enzyme called phosphatidylinositol synthase, also known as CDIPT, which catalyzes a reversible headgroup exchange reaction on its substrate liponucleotide CDP-diacylglycerol resulting in the incorporation of inositol to generate phosphatidylinositol and the release of CMP. Inositol 29-37 CDP-diacylglycerol--inositol 3-phosphatidyltransferase Homo sapiens 125-130 26616142-2 2016 Autophagy, a major pathway for degradation of macromolecules in the vacuole, is activated by these stress agents in a manner dependent on inositol-requiring enzyme 1b (IRE1b), and delivers endoplasmic reticulum fragments to the vacuole for degradation. Inositol 138-146 inositol requiring 1-1 Arabidopsis thaliana 168-173 26549806-0 2015 Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1alpha-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells. Inositol 61-69 Jun proto-oncogene, AP-1 transcription factor subunit Homo sapiens 94-99 26549806-6 2015 The endoplasmic reticulum (ER) stress responses were also apparently stimulated by GA by triggering the inositol-requiring enzyme 1alpha (IRE1alpha) pathway. Inositol 104-112 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 138-147 26678256-5 2015 The potential beneficial effect on improving insulin sensitivity suggests that myo-inositol may be useful for women in preventing gestational diabetes. Inositol 79-91 insulin Homo sapiens 45-52 26331676-3 2015 Recent findings have linked endoplasmic reticulum stress responses mediated by inositol-requiring enzyme 1alpha-dependent messenger RNA splicing (activation) of X-box-binding protein-1 (XBP-1s) to inflammation in peripheral macrophages. Inositol 79-87 X-box binding protein 1 Homo sapiens 161-184 26468289-6 2015 Knockdown of talin1, a protein that helps regulate PIP5 kinases, accelerated rundown of cytoplasmic Ca(2+) oscillations, and these could not be rescued by inositol or PI4P. Inositol 155-163 talin 1 Homo sapiens 13-19 26479434-1 2015 In recent years, interest has been focused to the study of the two major inositol stereoisomers: myo-inositol (MI) and d-chiro-inositol (DCI), because of their involvement, as second messengers of insulin, in several insulin-dependent processes, such as metabolic syndrome and polycystic ovary syndrome. Inositol 97-109 insulin Homo sapiens 197-204 26479434-1 2015 In recent years, interest has been focused to the study of the two major inositol stereoisomers: myo-inositol (MI) and d-chiro-inositol (DCI), because of their involvement, as second messengers of insulin, in several insulin-dependent processes, such as metabolic syndrome and polycystic ovary syndrome. Inositol 97-109 insulin Homo sapiens 217-224 26479434-1 2015 In recent years, interest has been focused to the study of the two major inositol stereoisomers: myo-inositol (MI) and d-chiro-inositol (DCI), because of their involvement, as second messengers of insulin, in several insulin-dependent processes, such as metabolic syndrome and polycystic ovary syndrome. Inositol 119-135 insulin Homo sapiens 197-204 26479434-1 2015 In recent years, interest has been focused to the study of the two major inositol stereoisomers: myo-inositol (MI) and d-chiro-inositol (DCI), because of their involvement, as second messengers of insulin, in several insulin-dependent processes, such as metabolic syndrome and polycystic ovary syndrome. Inositol 119-135 insulin Homo sapiens 217-224 26428274-6 2015 Regarding the association with clinical improvement, remitters showed an increase in myoinositol levels (mI/tCr) after lithium treatment compared to non-remitters. Inositol 85-96 T cell receptor beta variable 20/OR9-2 (non-functional) Homo sapiens 108-111 26456051-0 2015 SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells. Inositol 22-30 inositol polyphosphate phosphatase like 1 Homo sapiens 46-51 26456051-0 2015 SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells. Inositol 22-30 mechanistic target of rapamycin kinase Homo sapiens 161-165 26456051-0 2015 SH2 domain-containing inositol 5-phosphatase (SHIP2) inhibition ameliorates high glucose-induced de-novo lipogenesis and VLDL production through regulating AMPK/mTOR/SREBP1 pathway and ROS production in HepG2 cells. Inositol 22-30 sterol regulatory element binding transcription factor 1 Homo sapiens 166-172 26297348-4 2015 Occupation of the Gq protein-coupled TRH receptor in the prolactin-producing lactotroph increases the turnover of inositol, which in turn activates the protein kinase C pathway and the release of Ca(2+) from storage sites. Inositol 114-122 thyrotropin releasing hormone Rattus norvegicus 37-40 26297348-4 2015 Occupation of the Gq protein-coupled TRH receptor in the prolactin-producing lactotroph increases the turnover of inositol, which in turn activates the protein kinase C pathway and the release of Ca(2+) from storage sites. Inositol 114-122 prolactin Rattus norvegicus 57-66 26624279-8 2015 A multivariate logistic regression model assessed the influence of three parameters on the CBU utilization rate: ethnic background, total nucleated and CD34+ cell counts. Inositol 91-94 CD34 molecule Homo sapiens 152-156 26613949-0 2015 The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Inositol 30-38 Inositol 1,4,5-triphosphate kinase 2 Drosophila melanogaster 71-76 26613949-0 2015 The wavy Mutation Maps to the Inositol 1,4,5-Trisphosphate 3-Kinase 2 (IP3K2) Gene of Drosophila and Interacts with IP3R to Affect Wing Development. Inositol 30-38 Inositol 1,4,5,-trisphosphate receptor Drosophila melanogaster 116-120 26573460-4 2015 The inactivation of the ceramidase gene YDC1, overexpression of the inositol phosphosphingolipid phospholipase C gene ISC1, and endoplasmic reticulum localization of the DES1 gene product resulted in enhanced production of ceramide-NS. Inositol 68-76 inositol phosphosphingolipid phospholipase Saccharomyces cerevisiae S288C 118-122 26475925-5 2015 In neutrophils, complement 5a (C5a) inspires strong ER stress through inositol-requiring kinase 1a and, to a less extent, the protein kinase R-like ER kinase signaling pathway. Inositol 70-78 hemolytic complement Mus musculus 31-34 25990477-5 2015 RESULTS: Vascular permeability, VEGF and COX-2 expressions were reduced in animals treated with MI and/or metformin. Inositol 96-98 vascular endothelial growth factor A Rattus norvegicus 32-36 25990477-5 2015 RESULTS: Vascular permeability, VEGF and COX-2 expressions were reduced in animals treated with MI and/or metformin. Inositol 96-98 cytochrome c oxidase II, mitochondrial Rattus norvegicus 41-46 26578948-5 2015 Although (1)H-MRS does not specifically differentiate between cell types, it quantifies certain metabolites that are highly enriched in astrocytes (e.g., Myo-inositol, mlns), or that are involved in metabolic shuttling between astrocytes and neurons (e.g., glutamate and glutamine). Inositol 154-166 MROS Homo sapiens 14-17 26469762-2 2015 Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1alpha) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in adult primary beta cells. Inositol 85-93 endoplasmic reticulum (ER) to nucleus signalling 1 Mus musculus 120-129 26469762-2 2015 Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1alpha) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in adult primary beta cells. Inositol 85-93 X-box binding protein 1 Mus musculus 143-166 26469762-2 2015 Here, we demonstrate that glucose activates the unfolded protein response transducer inositol-requiring enzyme 1 alpha (IRE1alpha) to initiate X-box-binding protein 1 (Xbp1) mRNA splicing in adult primary beta cells. Inositol 85-93 X-box binding protein 1 Mus musculus 168-172 26315405-4 2015 In vitro studies indicated that platelet-derived growth factor-BB triggered XBP1 splicing in SMCs via the interaction between platelet-derived growth factor receptor beta and the inositol-requiring enzyme 1alpha. Inositol 179-187 X-box binding protein 1 Homo sapiens 76-80 26753656-4 2015 After supplementation of myo-inositol with alpha-lipoic acid, insulin levels, BMI and ovarian volume were significantly reduced compared with myo-inositol alone. Inositol 25-37 insulin Homo sapiens 62-69 26869828-4 2015 METHODS: We investigated the Ca(2+)-antagonistic effect of KRG-TS on cyclic nucleotides-associated phosphorylation of inositol 1,4,5-trisphosphate receptor type I (IP3RI) and cyclic adenosine monophosphate (cAMP)-dependent protein kinase (PKA) in thrombin (0.05 U/mL)-stimulated human platelet aggregation. Inositol 118-126 coagulation factor II, thrombin Homo sapiens 247-255 26491824-8 2015 One of these is myo-inositol, a new insulin-sensitizing molecule which has been successfully administered to women suffering from PCOS. Inositol 16-28 insulin Homo sapiens 36-43 26496267-1 2015 To determine whether myo-inositol supplement will increase the action of endogenous insulin, which is mainly measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance.PubMed, Cochrane Library, Embase, and web of science were comprehensively searched using "gestational diabetes mellitus" and "myo-inositol" to identify relevant studies. Inositol 21-33 insulin Homo sapiens 84-91 26496267-1 2015 To determine whether myo-inositol supplement will increase the action of endogenous insulin, which is mainly measured by markers of insulin resistance such as homeostasis model assessment of insulin resistance.PubMed, Cochrane Library, Embase, and web of science were comprehensively searched using "gestational diabetes mellitus" and "myo-inositol" to identify relevant studies. Inositol 336-348 insulin Homo sapiens 84-91 26401443-16 2015 There is an association between higher mI/Cr in right hippocampus and worse cognitive function for the non-demented older adults, and the correlation could be modified by APOE status and age. Inositol 39-41 apolipoprotein E Homo sapiens 171-175 26379774-7 2015 Furthermore, the enhancement of proline or myo-inositol synthesis by overexpressing key gene PRO1 or INO1 conferred yeast strain significantly increased FAP tolerance. Inositol 43-55 glutamate 5-kinase Saccharomyces cerevisiae S288C 93-97 26379774-7 2015 Furthermore, the enhancement of proline or myo-inositol synthesis by overexpressing key gene PRO1 or INO1 conferred yeast strain significantly increased FAP tolerance. Inositol 43-55 inositol-3-phosphate synthase INO1 Saccharomyces cerevisiae S288C 101-105 26442007-5 2015 Furthermore, spermine activated the splicing of the bZIP60 transcript mediated by the ribonuclease activity of inositol-requiring enzyme 1 and also recruited bZIP17 and bZIP60 proteins from endoplasmic reticulum to nucleus. Inositol 111-119 basic region/leucine zipper motif 60 Arabidopsis thaliana 52-58 26352407-8 2015 In contrast, for the SLC5A11 locus, we found increased levels of myo-inositol in urine whereas mGWAS in blood reported decreased levels for the same genetic variant. Inositol 65-77 solute carrier family 5 member 11 Homo sapiens 21-28 26339674-10 2015 INTERPRETATION: Choline and myo-inositol levels in our patients are consistent with patterns of neuroinflammation observed in two INCL mouse models. Inositol 28-40 palmitoyl-protein thioesterase 1 Homo sapiens 130-134 25670222-7 2015 RESULTS: Our study showed that both myo-inositol (MI-PG) and D-chiro inositol (DCI-PG) treatments are able to significantly improve the regularity of the menstrual cycle, the Acne Score, the endocrine and metabolic parameters and the insulin-resistence in young, overweight, PCOS patients. Inositol 36-48 insulin Homo sapiens 234-241 25270370-4 2015 Here, by examining P23H rhodopsin knock-in mice, we found that the UPR inositol-requiring enzyme 1 (IRE1) signaling pathway is strongly activated in misfolded rhodopsin-expressing photoreceptors. Inositol 71-79 rhodopsin Mus musculus 24-33 25270370-4 2015 Here, by examining P23H rhodopsin knock-in mice, we found that the UPR inositol-requiring enzyme 1 (IRE1) signaling pathway is strongly activated in misfolded rhodopsin-expressing photoreceptors. Inositol 71-79 endoplasmic reticulum (ER) to nucleus signalling 2 Mus musculus 100-104 25270370-4 2015 Here, by examining P23H rhodopsin knock-in mice, we found that the UPR inositol-requiring enzyme 1 (IRE1) signaling pathway is strongly activated in misfolded rhodopsin-expressing photoreceptors. Inositol 71-79 rhodopsin Mus musculus 159-168 26241420-1 2015 OBJECTIVE: To evaluate whether myo-inositol supplementation, an insulin sensitizer, reduces the rate of gestational diabetes mellitus (GDM) and lowers insulin resistance in obese pregnant women. Inositol 31-43 insulin Homo sapiens 64-71 26241420-1 2015 OBJECTIVE: To evaluate whether myo-inositol supplementation, an insulin sensitizer, reduces the rate of gestational diabetes mellitus (GDM) and lowers insulin resistance in obese pregnant women. Inositol 31-43 insulin Homo sapiens 151-158 26241420-8 2015 Furthermore, women treated with myo-inositol showed a significantly greater reduction in the homeostasis model assessment of insulin resistance compared with the control group, -1.0+-3.1 compared with 0.1+-1.8 (P=.048). Inositol 32-44 insulin Homo sapiens 125-132 26241420-9 2015 CONCLUSION: Myo-inositol supplementation, started in the first trimester, in obese pregnant women seems to reduce the incidence in GDM through a reduction of insulin resistance. Inositol 12-24 insulin Homo sapiens 158-165 25347741-7 2015 Downregulation of inositol-requiring kinase 1alpha (IRE1alpha) and decreased splicing of XBP-1 were associated with the decreased survival of the EnR-stressed ERbeta1-expressing cells. Inositol 18-26 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 52-61 26108975-1 2015 Various ab initio calculations using the density-functional (DFT), the second order Moller-Plesset perturbation (MP2) and self-consistent reaction field (SCRF) theories were performed on thirteen theoretically possible inositol stereoisomers. Inositol 219-227 tryptase pseudogene 1 Homo sapiens 113-116 26194190-11 2015 GAA1 encodes a GPI transamidase complex subunit that adds GPI, which is required for inositol synthesis, to newly synthesized proteins, including mannoproteins. Inositol 85-93 GPI-anchor transamidase subunit GAA1 Saccharomyces cerevisiae S288C 0-4 26173697-3 2015 MRSA infection activated the most highly conserved unfolded protein response sensor, inositol-requiring enzyme 1alpha (IRE1alpha), which was necessary for robust bacterial killing in vitro and in vivo. Inositol 85-93 endoplasmic reticulum to nucleus signaling 1 Homo sapiens 119-128 26144237-5 2015 The results suggest a specific recognition mechanism of inositol group-containing lipids by NGF, which may help in the design of bioactive compounds that can be delivered by NGF. Inositol 56-64 nerve growth factor Mus musculus 92-95 26144237-5 2015 The results suggest a specific recognition mechanism of inositol group-containing lipids by NGF, which may help in the design of bioactive compounds that can be delivered by NGF. Inositol 56-64 nerve growth factor Mus musculus 174-177 25990651-1 2015 We previously reported that a chronic supplementation with myo-inositol (MI) improved insulin sensitivity and reduced fat accretion in mice. Inositol 59-71 insulin Homo sapiens 86-93 25990651-3 2015 In addition, some abnormalities in inositol metabolism were reported to be associated with insulin resistance in several animal and human studies. Inositol 35-43 insulin Homo sapiens 91-98 25990651-9 2015 Finally, we found some abnormalities in inositol metabolism in association with a diabetic phenotype (i.e. insulin resistance and fasting hyperglycaemia) in a DIO mouse model. Inositol 40-48 insulin Homo sapiens 107-114 26068456-6 2015 Our results reveal the presence of basal unconventional splicing of XBP1 mRNA in the nucleus that also requires inositol-requiring transmembrane kinase and endonuclease 1alpha (IRE1alpha) and can occur independently of acute ER stress. Inositol 112-120 X-box binding protein 1 Homo sapiens 68-72 26097456-6 2015 Real-time reporter assays showed that myo-inositol and D-pinitol shortened the period of the circadian reporter gene Per2-luc in NIH 3T3 cells. Inositol 38-50 period circadian clock 2 Mus musculus 117-121 26009185-6 2015 Biphenyl polyphosphates illustrate that simple non-inositol surrogates can be engineered to give prototype IP3R agonists or antagonists and act as templates for protein co-crystallization. Inositol 51-59 inositol 1,4,5-trisphosphate receptor type 3 Homo sapiens 107-111 24865414-7 2015 Biochemical analyses revealed that ESBL producers more frequently utilized inositol, ornithine, sorbitol, melibiose, and saccharose, whereas the control group more frequently used esculin, lysine, arginine, and dulcitol. Inositol 75-83 EsbL Escherichia coli 35-39 25871850-3 2015 Here we demonstrate that AngII-induces biphasic calcium entry in vascular smooth muscle cells, consisting of an immediate peak due to inositol tris-phosphate-dependent release of intracellular calcium, followed by a sustained transmembrane Ca(2+) influx through store-operated calcium channels (SOCs). Inositol 134-142 angiotensinogen (serpin peptidase inhibitor, clade A, member 8) Mus musculus 25-30 26048869-0 2015 Involvement of Arabidopsis Hexokinase1 in Cell Death Mediated by Myo-Inositol Accumulation. Inositol 65-77 hexokinase 1 Arabidopsis thaliana 27-38 26048869-2 2015 We recently identified the mips1 mutant of Arabidopsis thaliana, which is deficient for the enzyme catalyzing the limiting step of myo-inositol (MI) synthesis. Inositol 131-143 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 27-32 26125706-2 2015 This osmolyte strategy requires the expression of specific osmolyte transporters such as betaine (BGT-1), myoinositol (SMIT), and taurine (TAUT). Inositol 106-117 solute carrier family 5 member 3 Homo sapiens 119-123 25978457-9 2015 The over-expression of MIPS1 increased the content of total inositol. Inositol 60-68 myo-inositol-1-phosphate synthase 1 Arabidopsis thaliana 23-28