PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32924931-3	2020	TMEM79 interacts with FZD during biogenesis and promotes FZD degradation independent of ZNRF3/RNF43 ubiquitin ligases (R-spondin receptors).	fzd	22-25	transmembrane protein 79	Homo sapiens	0-6
32924931-5	2020	TMEM79 specifically inhibits USP8 deubiquitination of FZD, thereby governing USP8 substrate specificity and promoting FZD degradation.	fzd	54-57	transmembrane protein 79	Homo sapiens	0-6
32924931-5	2020	TMEM79 specifically inhibits USP8 deubiquitination of FZD, thereby governing USP8 substrate specificity and promoting FZD degradation.	fzd	54-57	ubiquitin specific peptidase 8	Homo sapiens	29-33
32924931-5	2020	TMEM79 specifically inhibits USP8 deubiquitination of FZD, thereby governing USP8 substrate specificity and promoting FZD degradation.	fzd	54-57	ubiquitin specific peptidase 8	Homo sapiens	77-81
32924931-5	2020	TMEM79 specifically inhibits USP8 deubiquitination of FZD, thereby governing USP8 substrate specificity and promoting FZD degradation.	fzd	118-121	transmembrane protein 79	Homo sapiens	0-6
32924931-5	2020	TMEM79 specifically inhibits USP8 deubiquitination of FZD, thereby governing USP8 substrate specificity and promoting FZD degradation.	fzd	118-121	ubiquitin specific peptidase 8	Homo sapiens	29-33
31235524-10	2019	Our observations agree with previous results arguing for FZD conformation-dependent functional selectivity between DVL and heterotrimeric G proteins.	fzd	57-60	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	115-118
35378415-10	2022	The in vivo data showed that FZD restored the cartilage degeneration in MIA-induced OA rats by ameliorating pain behavior parameters, recovering histopathological alterations, benefitting cartilage anabolism (up-regulating Col2 expression), and suppressing catabolism (down-regulating MMP13 and Col10 expressions).	fzd	29-32	matrix metallopeptidase 13	Rattus norvegicus	285-290
35378415-12	2022	The overlapping results of RNA-seq and network pharmacology analysis suggested that PI3K/Akt signaling mediated the anti-OA mechanism of FZD, which was verified by qPCR and Western blot experiments.	fzd	137-140	AKT serine/threonine kinase 1	Rattus norvegicus	89-92