PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
30334373-0	2019	Euxanthone Impairs the Metastatic Potential of Osteosarcoma by Reducing COX-2 Expression.	euxanthone	0-10	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
32800580-0	2020	Retraction notice to "Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediated via Nrf2" [Life Sci.	euxanthone	48-58	NFE2 like bZIP transcription factor 2	Homo sapiens	122-126
31922313-0	2020	Euxanthone Represses the Proliferation, Migration, and Invasion of Glioblastoma Cells by modulating STAT3/SHP-1 signalling.	euxanthone	0-10	signal transducer and activator of transcription 3	Homo sapiens	100-105
31922313-0	2020	Euxanthone Represses the Proliferation, Migration, and Invasion of Glioblastoma Cells by modulating STAT3/SHP-1 signalling.	euxanthone	0-10	nuclear receptor subfamily 0 group B member 2	Homo sapiens	106-111
31922313-12	2020	Western blotting results revealed that the levels of p21, p27, cleaved caspase-3, Bax, TIMP-3, and E-cadherin were up-regulated while, the levels of CDK4, CDK6, pro-caspase-3, Bcl-2, MMP-2, MMP-9, N-cadherin, and Vimentin were down-regulated by euxanthone.	euxanthone	245-255	H3 histone pseudogene 16	Homo sapiens	53-56
31922313-13	2020	In addition, the expression of p-STAT3 was decreased, while the expression of SHP-1 was up-regulated by euxanthone.	euxanthone	104-114	nuclear receptor subfamily 0 group B member 2	Homo sapiens	78-83
31922313-14	2020	We proposed that euxanthone could repress the malignant behavior of glioblastoma cells through suppression of STAT3 phosphorylation and activation of SHP-1.	euxanthone	17-27	signal transducer and activator of transcription 3	Homo sapiens	110-115
31922313-14	2020	We proposed that euxanthone could repress the malignant behavior of glioblastoma cells through suppression of STAT3 phosphorylation and activation of SHP-1.	euxanthone	17-27	nuclear receptor subfamily 0 group B member 2	Homo sapiens	150-155
30334373-4	2019	COX-2-over-expressing plasmid was applied to transfect OS cells to assess whether COX-2 affects the anti-metastatic function of euxanthone.	euxanthone	128-138	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
30334373-5	2019	PDCD4 knockdown and miR-21 mimic were applied to assess whether euxanthone suppresses the transactivation of c-jun via modulating miR-21-PDCD4 signaling.	euxanthone	64-74	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	109-114
30334373-9	2019	Our experimental data also showed that repression of COX-2 by euxanthone mediated its anti-metastatic activities.	euxanthone	62-72	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	53-58
30334373-10	2019	Moreover, our findings revealed that euxanthone modulated the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway.	euxanthone	37-47	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	62-67
30334373-10	2019	Moreover, our findings revealed that euxanthone modulated the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway.	euxanthone	37-47	microRNA 21	Homo sapiens	91-97
30334373-10	2019	Moreover, our findings revealed that euxanthone modulated the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway.	euxanthone	37-47	programmed cell death 4	Homo sapiens	98-103
30334373-10	2019	Moreover, our findings revealed that euxanthone modulated the COX-2 expression through the miR-21/PDCD4/c-jun signaling pathway.	euxanthone	37-47	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	104-109
30890405-0	2019	Cytoprotective effects of euxanthone against ox-LDL-induced endothelial cell injury is mediated via Nrf2.	euxanthone	26-36	NFE2 like bZIP transcription factor 2	Homo sapiens	100-104
30927203-17	2019	More importantly, our results provide the experimental evidence that euxanthone confers neuroprotection by upregulating Nrf2 expression.	euxanthone	69-79	NFE2 like bZIP transcription factor 2	Rattus norvegicus	120-124
30890405-10	2019	In addition, euxanthone also significantly reversed ox-LDL-triggered loss of mitochondrial membrane potential (MMP), cytochrome C release from mitochondria to cytosol, cleavage of caspase-3 and PARP, and increase in Bax/Bcl-2 ratio.	euxanthone	13-23	cytochrome c, somatic	Homo sapiens	117-129
30890405-10	2019	In addition, euxanthone also significantly reversed ox-LDL-triggered loss of mitochondrial membrane potential (MMP), cytochrome C release from mitochondria to cytosol, cleavage of caspase-3 and PARP, and increase in Bax/Bcl-2 ratio.	euxanthone	13-23	caspase 3	Homo sapiens	180-189
30890405-10	2019	In addition, euxanthone also significantly reversed ox-LDL-triggered loss of mitochondrial membrane potential (MMP), cytochrome C release from mitochondria to cytosol, cleavage of caspase-3 and PARP, and increase in Bax/Bcl-2 ratio.	euxanthone	13-23	collagen type XI alpha 2 chain	Homo sapiens	194-198
30890405-10	2019	In addition, euxanthone also significantly reversed ox-LDL-triggered loss of mitochondrial membrane potential (MMP), cytochrome C release from mitochondria to cytosol, cleavage of caspase-3 and PARP, and increase in Bax/Bcl-2 ratio.	euxanthone	13-23	BCL2 associated X, apoptosis regulator	Homo sapiens	216-219
30890405-10	2019	In addition, euxanthone also significantly reversed ox-LDL-triggered loss of mitochondrial membrane potential (MMP), cytochrome C release from mitochondria to cytosol, cleavage of caspase-3 and PARP, and increase in Bax/Bcl-2 ratio.	euxanthone	13-23	BCL2 apoptosis regulator	Homo sapiens	220-225
30890405-11	2019	Pre-treatment with euxanthone markedly suppressed ox-LDL-induced ROS generation and inhibition of antioxidant enzymes, as well as the up-regulation of pro-inflammatory factors like MCP-1, IL-1beta and TNF-alpha in the HUVECs.	euxanthone	19-29	C-C motif chemokine ligand 2	Homo sapiens	181-186
30890405-11	2019	Pre-treatment with euxanthone markedly suppressed ox-LDL-induced ROS generation and inhibition of antioxidant enzymes, as well as the up-regulation of pro-inflammatory factors like MCP-1, IL-1beta and TNF-alpha in the HUVECs.	euxanthone	19-29	interleukin 1 beta	Homo sapiens	188-196
30890405-11	2019	Pre-treatment with euxanthone markedly suppressed ox-LDL-induced ROS generation and inhibition of antioxidant enzymes, as well as the up-regulation of pro-inflammatory factors like MCP-1, IL-1beta and TNF-alpha in the HUVECs.	euxanthone	19-29	tumor necrosis factor	Homo sapiens	201-210
30890405-12	2019	Euxanthone up-regulated and activated Nrf2 by repressing Keap1, and increased the expression of its downstream genes HO-1 and NQO-1.	euxanthone	0-10	NFE2 like bZIP transcription factor 2	Homo sapiens	38-42
30890405-12	2019	Euxanthone up-regulated and activated Nrf2 by repressing Keap1, and increased the expression of its downstream genes HO-1 and NQO-1.	euxanthone	0-10	kelch like ECH associated protein 1	Homo sapiens	57-62
30890405-12	2019	Euxanthone up-regulated and activated Nrf2 by repressing Keap1, and increased the expression of its downstream genes HO-1 and NQO-1.	euxanthone	0-10	NAD(P)H quinone dehydrogenase 1	Homo sapiens	126-131
30890405-13	2019	Nrf2 knockdown abrogated the cyto-protective, anti-apoptotic, anti-oxidant and anti-inflammatory effects of euxanthone in ox-LDL-treated HUVECs.	euxanthone	108-118	NFE2 like bZIP transcription factor 2	Homo sapiens	0-4
30890405-14	2019	Finally, euxanthone activated Nrf2 via the MAPK pathway and blocking the latter likewise negated the protective effects of euxanthone against cell ox-LDL.	euxanthone	9-19	NFE2 like bZIP transcription factor 2	Homo sapiens	30-34
30345461-2	2018	The present study was aimed at exploring the protective effects of euxanthone against Abeta-induced neurotoxicity both in vivo and in vitro.	euxanthone	67-77	amyloid beta precursor protein	Rattus norvegicus	86-91
30556857-13	2018	Meanwhile, our results showed that euxanthone promoted cell death in a caspase-2 dependent manner.	euxanthone	35-45	caspase 2	Homo sapiens	71-80
33777443-0	2021	Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K/Akt signaling pathway in a rat model.	euxanthone	0-10	mitogen activated protein kinase 14	Rattus norvegicus	94-97
29984416-0	2018	Euxanthone inhibits glycolysis and triggers mitochondria-mediated apoptosis by targeting hexokinase 2 in epithelial ovarian cancer.	euxanthone	0-10	hexokinase 2	Homo sapiens	89-101
30144452-0	2018	Euxanthone suppresses tumor growth and metastasis in colorectal cancer via targeting CIP2A/PP2A pathway.	euxanthone	0-10	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	85-90
30144452-0	2018	Euxanthone suppresses tumor growth and metastasis in colorectal cancer via targeting CIP2A/PP2A pathway.	euxanthone	0-10	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	91-95
30144452-9	2018	To validate the role of cancerous inhibitor of PP2A (CIP2A) in the anti-cancer effects of euxanthone, plasmid overexpressing CIP2A and shRNA targeting CIP2A were used in in vitro assays.	euxanthone	90-100	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	24-51
30144452-9	2018	To validate the role of cancerous inhibitor of PP2A (CIP2A) in the anti-cancer effects of euxanthone, plasmid overexpressing CIP2A and shRNA targeting CIP2A were used in in vitro assays.	euxanthone	90-100	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	53-58
30144452-10	2018	KEY FINDINGS: Euxanthone decreased cell viability and increased apoptosis in CRC cells, in addition to restraining migration, invasion and EMT.	euxanthone	14-24	IL2 inducible T cell kinase	Mus musculus	139-142
30144452-12	2018	iTRAQ analysis identified CIP2A as the primary target responsible for the anticancer effects of euxanthone.	euxanthone	96-106	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	26-31
30144452-13	2018	The mediatory role of CIP2A was validated when the anticancer activity of euxanthone was significantly blocked by CIP2A overexpression, while CIP2A knockdown sensitized the CRC cells to euxanthone.	euxanthone	74-84	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	22-27
30144452-13	2018	The mediatory role of CIP2A was validated when the anticancer activity of euxanthone was significantly blocked by CIP2A overexpression, while CIP2A knockdown sensitized the CRC cells to euxanthone.	euxanthone	74-84	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	114-119
30144452-13	2018	The mediatory role of CIP2A was validated when the anticancer activity of euxanthone was significantly blocked by CIP2A overexpression, while CIP2A knockdown sensitized the CRC cells to euxanthone.	euxanthone	74-84	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	114-119
30144452-13	2018	The mediatory role of CIP2A was validated when the anticancer activity of euxanthone was significantly blocked by CIP2A overexpression, while CIP2A knockdown sensitized the CRC cells to euxanthone.	euxanthone	186-196	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	22-27
30144452-14	2018	SIGNIFICANCE: Euxanthone exerts anti-cancer effects in vitro and in vivo in CRC by targeting CIP2A/PP2A signaling.	euxanthone	14-24	cell proliferation regulating inhibitor of protein phosphatase 2A	Mus musculus	93-98
30144452-14	2018	SIGNIFICANCE: Euxanthone exerts anti-cancer effects in vitro and in vivo in CRC by targeting CIP2A/PP2A signaling.	euxanthone	14-24	protein phosphatase 2, regulatory subunit A, alpha	Mus musculus	99-103
29680739-8	2018	To examine the role of STAT3 in the induction of autophagy and apoptosis by euxanthone, STAT3 expression was suppressed using siRNA.	euxanthone	76-86	signal transducer and activator of transcription 3	Homo sapiens	23-28
29680739-14	2018	Furthermore, our results revealed that euxanthone induced apoptosis and autophagy by modulating pSTAT3/Bcl-2 signaling.	euxanthone	39-49	BCL2 apoptosis regulator	Homo sapiens	103-108
16546434-0	2006	Involvement of protein kinase C and E2F-5 in euxanthone-induced neurite differentiation of neuroblastoma.	euxanthone	45-55	E2F transcription factor 5	Mus musculus	36-41
16546434-6	2006	Among the 14 identified proteins, E2F transcription factor 5 (E2F-5) was significantly up-regulated after euxanthone treatment.	euxanthone	106-116	E2F transcription factor 5	Mus musculus	34-60
16546434-6	2006	Among the 14 identified proteins, E2F transcription factor 5 (E2F-5) was significantly up-regulated after euxanthone treatment.	euxanthone	106-116	E2F transcription factor 5	Mus musculus	62-67
16546434-7	2006	Go6976, a protein kinase C (PKC) alpha/betaI inhibitor, was found to inhibit neuritogenesis and expression of E2F-5 in the euxanthone-treated BU-1 cells, while SH-6, the Akt/PKB inhibitor, had no inhibitory effect.	euxanthone	123-133	protein kinase C, alpha L homeolog	Xenopus laevis	10-38
16546434-7	2006	Go6976, a protein kinase C (PKC) alpha/betaI inhibitor, was found to inhibit neuritogenesis and expression of E2F-5 in the euxanthone-treated BU-1 cells, while SH-6, the Akt/PKB inhibitor, had no inhibitory effect.	euxanthone	123-133	E2F transcription factor 5	Mus musculus	110-115
16546434-8	2006	The gene silencing of E2F-5 by small interfering RNA (siRNA) was found to abolish the euxanthone-induced neurite outgrowth.	euxanthone	86-96	E2F transcription factor 5	Mus musculus	22-27
16546434-9	2006	In conclusion, these results indicated that the transcription factor E2F-5 was actively involved in the regulation of euxanthone-induced neurite outgrowth via PKC pathway.	euxanthone	118-128	E2F transcription factor 5	Mus musculus	69-74
11488451-2	2001	In this study, the role of protein kinase C (PKC) and the expression of various PKC isoforms in euxanthone-treated BU-1 cells were examined.	euxanthone	96-106	protein kinase C, alpha	Mus musculus	80-83
11488451-4	2001	Differential regulation and expression of PKC isoforms was observed in BU-1 cells treated with 100 microM euxanthone.	euxanthone	106-116	protein kinase C, alpha	Mus musculus	42-45
11488451-9	2001	A significant reduction of the euxanthone-induced neuritogenic effect was also observed when the PKC isoform-specific inhibitor Go6976 was included in the culture.	euxanthone	31-41	protein kinase C, alpha	Mus musculus	97-100
11488451-10	2001	These results suggest that the euxanthone-induced differentiation of the neuroblastoma BU-1 cells may be mediated through the differential expression of PKC-alpha, -beta, -delta, -lambda and -zeta isoforms.	euxanthone	31-41	protein kinase C, alpha	Mus musculus	153-196
33777443-0	2021	Euxanthone inhibits traumatic spinal cord injury via anti-oxidative stress and suppression of p38 and PI3K/Akt signaling pathway in a rat model.	euxanthone	0-10	AKT serine/threonine kinase 1	Rattus norvegicus	107-110
34655103-0	2022	Euxanthone inhibits lipopolysaccharide-induced injury, inflammatory response, and MUC5AC hypersecretion in human airway epithelial cells by the TLR4/MyD88 pathway.	euxanthone	0-10	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	82-88
34745815-0	2021	Modulatory effect of euxanthone in liver cancer-bearing obese mice: crosstalk between PPARgamma and TIMP3 signalling axes.	euxanthone	21-31	peroxisome proliferator activated receptor gamma	Mus musculus	86-95
34745815-0	2021	Modulatory effect of euxanthone in liver cancer-bearing obese mice: crosstalk between PPARgamma and TIMP3 signalling axes.	euxanthone	21-31	tissue inhibitor of metalloproteinase 3	Mus musculus	100-105
34655103-0	2022	Euxanthone inhibits lipopolysaccharide-induced injury, inflammatory response, and MUC5AC hypersecretion in human airway epithelial cells by the TLR4/MyD88 pathway.	euxanthone	0-10	toll like receptor 4	Homo sapiens	144-148
34655103-0	2022	Euxanthone inhibits lipopolysaccharide-induced injury, inflammatory response, and MUC5AC hypersecretion in human airway epithelial cells by the TLR4/MyD88 pathway.	euxanthone	0-10	MYD88 innate immune signal transduction adaptor	Homo sapiens	149-154
34655103-11	2022	LPS exposure evoked viability reduction, increased LDH release and apoptosis, and induced production of inflammatory cytokines (IL-6, IL-8, and MCP-1) and MUC5AC hypersecretion in human AECs, which were alleviated by euxanthone.	euxanthone	217-227	interleukin 6	Homo sapiens	128-132
34655103-11	2022	LPS exposure evoked viability reduction, increased LDH release and apoptosis, and induced production of inflammatory cytokines (IL-6, IL-8, and MCP-1) and MUC5AC hypersecretion in human AECs, which were alleviated by euxanthone.	euxanthone	217-227	C-X-C motif chemokine ligand 8	Homo sapiens	134-138
34655103-11	2022	LPS exposure evoked viability reduction, increased LDH release and apoptosis, and induced production of inflammatory cytokines (IL-6, IL-8, and MCP-1) and MUC5AC hypersecretion in human AECs, which were alleviated by euxanthone.	euxanthone	217-227	C-C motif chemokine ligand 2	Homo sapiens	144-149
34655103-11	2022	LPS exposure evoked viability reduction, increased LDH release and apoptosis, and induced production of inflammatory cytokines (IL-6, IL-8, and MCP-1) and MUC5AC hypersecretion in human AECs, which were alleviated by euxanthone.	euxanthone	217-227	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	155-161
34655103-12	2022	Mechanistically, we validated that euxanthone attenuated LPS-induced activation of TLR4/MyD88 pathway in AECs.	euxanthone	35-45	toll like receptor 4	Homo sapiens	83-87
34655103-12	2022	Mechanistically, we validated that euxanthone attenuated LPS-induced activation of TLR4/MyD88 pathway in AECs.	euxanthone	35-45	MYD88 innate immune signal transduction adaptor	Homo sapiens	88-93
34655103-13	2022	Moreover, inhibition of the TLR4/MyD88 pathway enhanced the inhibitory effect of euxanthone on LPS-induced cell injury, inflammatory response and MUC5AC expression.	euxanthone	81-91	toll like receptor 4	Homo sapiens	28-32
34655103-13	2022	Moreover, inhibition of the TLR4/MyD88 pathway enhanced the inhibitory effect of euxanthone on LPS-induced cell injury, inflammatory response and MUC5AC expression.	euxanthone	81-91	MYD88 innate immune signal transduction adaptor	Homo sapiens	33-38
34655103-13	2022	Moreover, inhibition of the TLR4/MyD88 pathway enhanced the inhibitory effect of euxanthone on LPS-induced cell injury, inflammatory response and MUC5AC expression.	euxanthone	81-91	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	146-152
34655103-14	2022	In conclusion, euxanthone attenuated LPS-induced cell injury, inflammatory response, and MUC5AC expression in AECs by inhibiting the activation of TLR4/MyD88 pathway.	euxanthone	15-25	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	89-95
34655103-14	2022	In conclusion, euxanthone attenuated LPS-induced cell injury, inflammatory response, and MUC5AC expression in AECs by inhibiting the activation of TLR4/MyD88 pathway.	euxanthone	15-25	toll like receptor 4	Homo sapiens	147-151
34655103-14	2022	In conclusion, euxanthone attenuated LPS-induced cell injury, inflammatory response, and MUC5AC expression in AECs by inhibiting the activation of TLR4/MyD88 pathway.	euxanthone	15-25	MYD88 innate immune signal transduction adaptor	Homo sapiens	152-157