PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
20414199-3	2010	Molecular determinants of TRPV1 activation by capsaicin, allicin, acid, ammonia and voltage have been identified.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
20403666-9	2010	Immunohistochemistry showed that loss of CGRP immunoreactivity, a surrogate marker for TRPV1-expressing fibers, extended at least to the corneal-scleral boundary and displayed a progressive return, coincident with the return of capsaicin sensitivity.	Capsaicin	228-237	calcitonin-related polypeptide alpha	Rattus norvegicus	41-45
20532232-4	2010	Stimuli of peri-vascular vasodilator sensory-motor nerves such as capsaicin not only reduced but also terminated long-lasting effects of ET-1.	Capsaicin	66-75	endothelin 1	Rattus norvegicus	137-141
20532232-6	2010	Using 2-photon laser scanning microscopy in vital intact arteries, capsaicin and CGRP, but not ET(A)-antagonism, were observed to promote dissociation of pre-existing ET-1/ET(A)-receptor complexes.	Capsaicin	67-76	endothelin 1	Rattus norvegicus	167-171
20304040-16	2010	EtOH, HEX and AcOEt (62.5-250 mg/kg) produced a significant antinociceptive effect in the formalin and capsaicin tests.	Capsaicin	103-112	hematopoietically expressed homeobox	Mus musculus	6-9
20219639-4	2010	The effects of M1 receptor activation on IPSCs were occlusive with those of metabotropic glutamate receptor 5 stimulation, and were prevented in the presence of capsaicin, agonist of TRPV1 channels.	Capsaicin	161-170	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	183-188
20219639-6	2010	Accordingly, both capsaicin and URB597 effects were absent in mice lacking TRPV1 channels.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	75-80
20646592-5	2010	And the expressions of cell cycle protein P53, P21, CDK2 were detected by Western blot after the treatment of capsaicin.	Capsaicin	110-119	tumor protein p53	Homo sapiens	42-45
20497578-0	2010	Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P. Recent research has proposed a pathway in which sensory neurons expressing the capsaicin activated ion channel TRPV1 are required for histamine-induced itch and subsequent scratching behavior.	Capsaicin	172-181	transient receptor potential cation channel subfamily V member 1	Heterocephalus glaber	204-209
20646592-5	2010	And the expressions of cell cycle protein P53, P21, CDK2 were detected by Western blot after the treatment of capsaicin.	Capsaicin	110-119	H3 histone pseudogene 16	Homo sapiens	47-50
20646592-5	2010	And the expressions of cell cycle protein P53, P21, CDK2 were detected by Western blot after the treatment of capsaicin.	Capsaicin	110-119	cyclin dependent kinase 2	Homo sapiens	52-56
20646592-11	2010	After a 48-hour treatment with capsaicin, the expressions of P53 and P21 were up-regulated in contrary to the expression of CDK2.	Capsaicin	31-40	tumor protein p53	Homo sapiens	61-64
20646592-11	2010	After a 48-hour treatment with capsaicin, the expressions of P53 and P21 were up-regulated in contrary to the expression of CDK2.	Capsaicin	31-40	H3 histone pseudogene 16	Homo sapiens	69-72
20646592-11	2010	After a 48-hour treatment with capsaicin, the expressions of P53 and P21 were up-regulated in contrary to the expression of CDK2.	Capsaicin	31-40	cyclin dependent kinase 2	Homo sapiens	124-128
20646592-12	2010	CONCLUSION: Capsaicin induces the cell cycle arrest of bladder cancer RT4 cells G(0)/G(1) phase and growth inhibition via TRPV1 receptor by modulating the expression of P53, P21 and CDK2.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
20646592-12	2010	CONCLUSION: Capsaicin induces the cell cycle arrest of bladder cancer RT4 cells G(0)/G(1) phase and growth inhibition via TRPV1 receptor by modulating the expression of P53, P21 and CDK2.	Capsaicin	12-21	tumor protein p53	Homo sapiens	169-172
20646592-12	2010	CONCLUSION: Capsaicin induces the cell cycle arrest of bladder cancer RT4 cells G(0)/G(1) phase and growth inhibition via TRPV1 receptor by modulating the expression of P53, P21 and CDK2.	Capsaicin	12-21	H3 histone pseudogene 16	Homo sapiens	174-177
20646592-12	2010	CONCLUSION: Capsaicin induces the cell cycle arrest of bladder cancer RT4 cells G(0)/G(1) phase and growth inhibition via TRPV1 receptor by modulating the expression of P53, P21 and CDK2.	Capsaicin	12-21	cyclin dependent kinase 2	Homo sapiens	182-186
20142268-3	2010	The intensity of activation was similar to that observed with the TRPV1 agonist, capsaicin.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	66-71
20354008-0	2010	Pharmacology of capsaicin-, anandamide-, and N-arachidonoyl-dopamine-evoked cell death in a homogeneous transient receptor potential vanilloid subtype 1 receptor population.	Capsaicin	16-25	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-152
20354008-7	2010	RESULTS: The TRPV1-selective agonist capsaicin, and the endovanilloids anandamide and N-arachidonoyl-dopamine (NADA), induced TRPV1-dependent delayed cell death in a concentration- and time-dependent manner.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
20354008-7	2010	RESULTS: The TRPV1-selective agonist capsaicin, and the endovanilloids anandamide and N-arachidonoyl-dopamine (NADA), induced TRPV1-dependent delayed cell death in a concentration- and time-dependent manner.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	126-131
20354008-9	2010	Release of cytochrome c from mitochondria, activation of caspase-3, and condensed nuclear chromatin were evident 6 h after capsaicin exposure, but cytotoxicity was unaffected by a pan-caspase inhibitor (zVAD-fmk, 50 microM).	Capsaicin	123-132	cytochrome c, somatic	Homo sapiens	11-23
20354008-9	2010	Release of cytochrome c from mitochondria, activation of caspase-3, and condensed nuclear chromatin were evident 6 h after capsaicin exposure, but cytotoxicity was unaffected by a pan-caspase inhibitor (zVAD-fmk, 50 microM).	Capsaicin	123-132	caspase 3	Homo sapiens	57-66
20354008-10	2010	CONCLUSIONS: We conclude that capsaicin, anandamide, and NADA can initiate TRPV1-dependent delayed cell death in neurone-like cells.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-80
20510015-0	2010	Capsaicin, a component of red peppers, stimulates protein kinase CKII activity.	Capsaicin	0-9	casein kinase 2 alpha 1	Homo sapiens	65-69
20510015-3	2010	Therefore, we examined the effect of capsaicin on CKII activity.	Capsaicin	37-46	casein kinase 2 alpha 1	Homo sapiens	50-54
20510015-6	2010	Capsaicin stimulated the catalytic activity of recombinant CKII tetramer, but not the CKIIalpha subunit.	Capsaicin	0-9	casein kinase 2 alpha 1	Homo sapiens	59-63
20510015-7	2010	Moreover, capsaicin enhanced the autophosphorylation of CKIIalpha and CKIIbeta.	Capsaicin	10-19	casein kinase 2 alpha 2	Homo sapiens	56-65
20510015-7	2010	Moreover, capsaicin enhanced the autophosphorylation of CKIIalpha and CKIIbeta.	Capsaicin	10-19	casein kinase 2 beta	Homo sapiens	70-78
20510015-8	2010	Taken together, our data suggest that capsaicin stimulates the phosphotransferase activity of CKII holoenzyme by interacting with the CKIIbeta subunit.	Capsaicin	38-47	casein kinase 2 alpha 1	Homo sapiens	94-98
20510015-8	2010	Taken together, our data suggest that capsaicin stimulates the phosphotransferase activity of CKII holoenzyme by interacting with the CKIIbeta subunit.	Capsaicin	38-47	casein kinase 2 beta	Homo sapiens	134-142
20419599-2	2010	TRPV1 mediates the tussive action of capsaicin, which is widely used in cough provocation studies.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
19800272-0	2010	Antinociceptive desensitizing actions of TRPV1 receptor agonists capsaicin, resiniferatoxin and N-oleoyldopamine as measured by determination of the noxious heat and cold thresholds in the rat.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	41-46
19800272-7	2010	In conclusion, using measurement of threshold temperatures eliciting nocifensive reactions in rats both in the hot and cold range revealed that capsaicin and RTX impair thermosensation in both noxious ranges due to a functional desensitization of peripheral terminals of TRPV1-expressing sensory neurons responsible for noxious heat and cold responsiveness.	Capsaicin	144-153	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	271-276
20232062-9	2010	Left DLPFC rTMS, together with the analgesic effect, was able to revert the effects of capsaicin-induced pain on motor cortex restoring normal MEP and SICI levels.	Capsaicin	87-96	PYD and CARD domain containing	Homo sapiens	5-15
20303522-6	2010	Capsaicin increased relaxant responses to all TRPA1 agonists.	Capsaicin	0-9	transient receptor potential cation channel subfamily A member 1	Homo sapiens	46-51
20421925-5	2010	The present manuscript fills this void of knowledge and explores the anti-proliferative effect of capsaicin in SCLC in vitro and in vivo.	Capsaicin	98-107	SCLC1	Homo sapiens	111-115
20421925-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: BrdU assays and PCNA ELISAs showed that capsaicin displays robust anti-proliferative activity in four human SCLC cell lines.	Capsaicin	72-81	proliferating cell nuclear antigen	Homo sapiens	48-52
20421925-6	2010	METHODOLOGY/PRINCIPAL FINDINGS: BrdU assays and PCNA ELISAs showed that capsaicin displays robust anti-proliferative activity in four human SCLC cell lines.	Capsaicin	72-81	SCLC1	Homo sapiens	140-144
20421925-9	2010	We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.	Capsaicin	49-58	thymidylate synthetase	Homo sapiens	160-180
20421925-9	2010	We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.	Capsaicin	49-58	cell division cycle 25A	Homo sapiens	182-188
20421925-9	2010	We found that the anti-proliferative activity of capsaicin is correlated with a decrease in the expression of E2F-responsive proliferative genes like cyclin E, thymidylate synthase, cdc25A and cdc6, both at mRNA and protein levels.	Capsaicin	49-58	cell division cycle 6	Homo sapiens	193-197
20421925-10	2010	The transcription factor E2F4 mediated the anti-proliferative activity of capsaicin.	Capsaicin	74-83	E2F transcription factor 4	Homo sapiens	25-29
20421925-11	2010	Ablation of E2F4 levels by siRNA methodology suppressed capsaicin-induced G1 arrest.	Capsaicin	56-65	E2F transcription factor 4	Homo sapiens	12-16
20421925-12	2010	ChIP assays demonstrated that capsaicin caused the recruitment of E2F4 and p130 on E2F-responsive proliferative promoters, thereby inhibiting cell proliferation.	Capsaicin	30-39	E2F transcription factor 4	Homo sapiens	66-70
20079377-2	2010	Having shown earlier, that activation of the afferent sensory nervous system by capsaicin induced epithelial cell proliferation and TGFalpha expression in vivo the aim of this study was to demonstrate, that neurotransmitters of the afferent sensory nervous system induce TGFalpha expression via mast cells and fibroblasts.	Capsaicin	80-89	transforming growth factor alpha	Homo sapiens	132-140
20079377-2	2010	Having shown earlier, that activation of the afferent sensory nervous system by capsaicin induced epithelial cell proliferation and TGFalpha expression in vivo the aim of this study was to demonstrate, that neurotransmitters of the afferent sensory nervous system induce TGFalpha expression via mast cells and fibroblasts.	Capsaicin	80-89	transforming growth factor alpha	Homo sapiens	271-279
20096813-4	2010	Capsazepine inhibited osteoclast formation and bone resorption in a dose dependent manner in bone marrow-osteoblast co-cultures and RANKL generated osteoclast cultures, whereas the TRPV1 agonist capsaicin enhanced RANKL and M-CSF stimulated osteoclast formation.	Capsaicin	195-204	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	181-186
20096813-4	2010	Capsazepine inhibited osteoclast formation and bone resorption in a dose dependent manner in bone marrow-osteoblast co-cultures and RANKL generated osteoclast cultures, whereas the TRPV1 agonist capsaicin enhanced RANKL and M-CSF stimulated osteoclast formation.	Capsaicin	195-204	tumor necrosis factor (ligand) superfamily, member 11	Mus musculus	214-219
20096813-4	2010	Capsazepine inhibited osteoclast formation and bone resorption in a dose dependent manner in bone marrow-osteoblast co-cultures and RANKL generated osteoclast cultures, whereas the TRPV1 agonist capsaicin enhanced RANKL and M-CSF stimulated osteoclast formation.	Capsaicin	195-204	colony stimulating factor 1 (macrophage)	Mus musculus	224-229
20110283-0	2010	NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3.	Capsaicin	49-58	glycogen synthase kinase 3 beta	Homo sapiens	123-131
20110283-0	2010	NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3.	Capsaicin	49-58	CCAAT enhancer binding protein beta	Homo sapiens	133-142
20110283-0	2010	NSAID-activated gene-1 as a molecular target for capsaicin-induced apoptosis through a novel molecular mechanism involving GSK3beta, C/EBPbeta and ATF3.	Capsaicin	49-58	activating transcription factor 3	Homo sapiens	147-151
20110283-3	2010	Our data demonstrate that capsaicin leads to induction of apoptosis and up-regulates NAG-1 gene expression at the transcriptional level.	Capsaicin	26-35	growth differentiation factor 15	Homo sapiens	85-90
20110283-4	2010	Overexpression of CCAAT/enhancer binding protein beta (C/EBPbeta) caused a significant increase of basal and capsaicin-induced NAG-1 promoter activity.	Capsaicin	109-118	CCAAT enhancer binding protein beta	Homo sapiens	18-53
20110283-4	2010	Overexpression of CCAAT/enhancer binding protein beta (C/EBPbeta) caused a significant increase of basal and capsaicin-induced NAG-1 promoter activity.	Capsaicin	109-118	CCAAT enhancer binding protein beta	Homo sapiens	55-64
20110283-4	2010	Overexpression of CCAAT/enhancer binding protein beta (C/EBPbeta) caused a significant increase of basal and capsaicin-induced NAG-1 promoter activity.	Capsaicin	109-118	growth differentiation factor 15	Homo sapiens	127-132
20110283-5	2010	We subsequently identified C/EBPbeta binding sites in the NAG-1 promoter responsible for capsaicin-induced NAG-1 transactivation.	Capsaicin	89-98	CCAAT enhancer binding protein beta	Homo sapiens	27-36
20110283-5	2010	We subsequently identified C/EBPbeta binding sites in the NAG-1 promoter responsible for capsaicin-induced NAG-1 transactivation.	Capsaicin	89-98	growth differentiation factor 15	Homo sapiens	58-63
20110283-5	2010	We subsequently identified C/EBPbeta binding sites in the NAG-1 promoter responsible for capsaicin-induced NAG-1 transactivation.	Capsaicin	89-98	growth differentiation factor 15	Homo sapiens	107-112
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	0-9	CCAAT enhancer binding protein beta	Homo sapiens	91-100
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	0-9	CCAAT enhancer binding protein beta	Homo sapiens	178-187
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	0-9	glycogen synthase kinase 3 beta	Homo sapiens	193-223
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	0-9	glycogen synthase kinase 3 beta	Homo sapiens	225-233
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	0-9	activating transcription factor 3	Homo sapiens	239-272
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	0-9	activating transcription factor 3	Homo sapiens	274-278
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	148-157	CCAAT enhancer binding protein beta	Homo sapiens	91-100
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	148-157	CCAAT enhancer binding protein beta	Homo sapiens	178-187
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	148-157	glycogen synthase kinase 3 beta	Homo sapiens	193-223
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	148-157	glycogen synthase kinase 3 beta	Homo sapiens	225-233
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	148-157	activating transcription factor 3	Homo sapiens	239-272
20110283-7	2010	Capsaicin treatment resulted in an increase of phosphorylated serine/threonine residues on C/EBPbeta, and the immunoprecipitation study showed that capsaicin enhanced binding of C/EBPbeta with glycogen synthase kinase 3beta (GSK3beta) and activating transcription factor 3 (ATF3).	Capsaicin	148-157	activating transcription factor 3	Homo sapiens	274-278
20110283-9	2010	Knockdown of C/EBPbeta, GSK3beta or ATF3 ameliorates NAG-1 expression induced by capsaicin treatment.	Capsaicin	81-90	CCAAT enhancer binding protein beta	Homo sapiens	13-22
20110283-9	2010	Knockdown of C/EBPbeta, GSK3beta or ATF3 ameliorates NAG-1 expression induced by capsaicin treatment.	Capsaicin	81-90	glycogen synthase kinase 3 beta	Homo sapiens	24-32
20110283-9	2010	Knockdown of C/EBPbeta, GSK3beta or ATF3 ameliorates NAG-1 expression induced by capsaicin treatment.	Capsaicin	81-90	activating transcription factor 3	Homo sapiens	36-40
20110283-9	2010	Knockdown of C/EBPbeta, GSK3beta or ATF3 ameliorates NAG-1 expression induced by capsaicin treatment.	Capsaicin	81-90	growth differentiation factor 15	Homo sapiens	53-58
20110283-10	2010	These data indicate that C/EBPbeta phosphorylation through GSK3beta may mediate capsaicin-induced expression of NAG-1 and apoptosis through cooperation with ATF3 in human colorectal cancer cells.	Capsaicin	80-89	CCAAT enhancer binding protein beta	Homo sapiens	25-34
20110283-10	2010	These data indicate that C/EBPbeta phosphorylation through GSK3beta may mediate capsaicin-induced expression of NAG-1 and apoptosis through cooperation with ATF3 in human colorectal cancer cells.	Capsaicin	80-89	glycogen synthase kinase 3 beta	Homo sapiens	59-67
20110283-10	2010	These data indicate that C/EBPbeta phosphorylation through GSK3beta may mediate capsaicin-induced expression of NAG-1 and apoptosis through cooperation with ATF3 in human colorectal cancer cells.	Capsaicin	80-89	growth differentiation factor 15	Homo sapiens	112-117
20110283-10	2010	These data indicate that C/EBPbeta phosphorylation through GSK3beta may mediate capsaicin-induced expression of NAG-1 and apoptosis through cooperation with ATF3 in human colorectal cancer cells.	Capsaicin	80-89	activating transcription factor 3	Homo sapiens	157-161
20164394-0	2010	Augmented sodium currents contribute to the enhanced excitability of small diameter capsaicin-sensitive sensory neurons isolated from Nf1+/- mice.	Capsaicin	84-93	neurofibromin 1	Mus musculus	134-137
20167675-0	2010	Activations of TRPA1 and P2X receptors are important in ROS-mediated stimulation of capsaicin-sensitive lung vagal afferents by cigarette smoke in rats.	Capsaicin	84-93	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	15-20
20307063-1	2010	The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a nonselective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat.	Capsaicin	180-189	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-70
20307063-1	2010	The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a nonselective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat.	Capsaicin	180-189	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	72-77
20145248-1	2010	The capsaicin receptor (TRPV1) is a nonselective cation channel that integrates multiple painful stimuli, including capsaicin, protons, and heat.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
20145248-2	2010	Protons facilitate the capsaicin- and heat-induced currents by decreasing thermal threshold or increasing agonist potency for TRPV1 activation (Tominaga, M., Caterina, M. J., Malmberg, A.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	126-131
20145248-4	2010	In the presence of saturating capsaicin, rat TRPV1 (rTRPV1) reaches full activation, with no further stimulation by protons.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	45-50
20145248-4	2010	In the presence of saturating capsaicin, rat TRPV1 (rTRPV1) reaches full activation, with no further stimulation by protons.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-58
20145248-5	2010	Human TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin.	Capsaicin	145-154	transient receptor potential cation channel subfamily V member 1	Homo sapiens	6-11
20145248-5	2010	Human TRPV1 (hTRPV1), a species ortholog with high homology to rTRPV1, is potentiated by extracellular protons and magnesium, even at saturating capsaicin.	Capsaicin	145-154	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-19
20145248-7	2010	By analysis of chimeric channels between hTRPV1 and rTRPV1, we found that transmembrane domain 1-4 (TM1-4) of TRPV1 determines whether protons can further open the fully capsaicin-bound receptors.	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-47
20145248-7	2010	By analysis of chimeric channels between hTRPV1 and rTRPV1, we found that transmembrane domain 1-4 (TM1-4) of TRPV1 determines whether protons can further open the fully capsaicin-bound receptors.	Capsaicin	170-179	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-58
20145248-7	2010	By analysis of chimeric channels between hTRPV1 and rTRPV1, we found that transmembrane domain 1-4 (TM1-4) of TRPV1 determines whether protons can further open the fully capsaicin-bound receptors.	Capsaicin	170-179	fibulin 7	Homo sapiens	100-105
20145248-7	2010	By analysis of chimeric channels between hTRPV1 and rTRPV1, we found that transmembrane domain 1-4 (TM1-4) of TRPV1 determines whether protons can further open the fully capsaicin-bound receptors.	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
20145248-9	2010	In contrast, hTRPV1 TM5-6 is required for magnesium augmentation of capsaicin efficacy.	Capsaicin	68-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-19
20145248-9	2010	In contrast, hTRPV1 TM5-6 is required for magnesium augmentation of capsaicin efficacy.	Capsaicin	68-77	tropomyosin 3	Homo sapiens	20-23
20145248-10	2010	Our results demonstrate that capsaicin efficacy of hTRPV1 correlates with the extracellular ion milieu and unravel the relevant structural basis of modulation by protons and magnesium.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-57
20176082-6	2010	Similar to ACEA, the vanilloid agonist capsaicin increased quantal content, and this effect was blocked by capsazepine, a TRPV1 antagonist.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
22444044-0	2010	The effect of vitamin E and plant extract mixture composed of carvacrol, cinnamaldehyde and capsaicin on oxidative stress induced by high PUFA load in young pigs.	Capsaicin	92-101	Polyunsaturated fatty acid percentage	Sus scrofa	138-142
20401963-3	2010	EXPERIMENTAL APPROACH: Modulation of capsaicin (CAP)- and low pH-induced currents was evaluated in TRPV1-expressing Xenopus oocytes.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	99-104
20401963-3	2010	EXPERIMENTAL APPROACH: Modulation of capsaicin (CAP)- and low pH-induced currents was evaluated in TRPV1-expressing Xenopus oocytes.	Capsaicin	48-51	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	99-104
20069556-6	2010	Exposure of capsaicin also causes increased accumulation of ubiquitinated proteins as wells as various target substrates of proteasome like p53 and Bax and p27.	Capsaicin	12-21	transformation related protein 53, pseudogene	Mus musculus	140-143
20069556-6	2010	Exposure of capsaicin also causes increased accumulation of ubiquitinated proteins as wells as various target substrates of proteasome like p53 and Bax and p27.	Capsaicin	12-21	BCL2-associated X protein	Mus musculus	148-151
20069556-6	2010	Exposure of capsaicin also causes increased accumulation of ubiquitinated proteins as wells as various target substrates of proteasome like p53 and Bax and p27.	Capsaicin	12-21	dynactin 6	Mus musculus	156-159
19840269-0	2010	Ghrelin stimulates gastric motility of the guinea pig through activation of a capsaicin-sensitive neural pathway: in vivo and in vitro functional studies.	Capsaicin	78-87	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
19840269-16	2010	CONCLUSIONS & INFERENCES: Ghrelin stimulates gastric motility of the guinea pig through activation of capsaicin-sensitive vago-vagal reflex pathway including efferent cholinergic neurons.	Capsaicin	106-115	ghrelin and obestatin prepropeptide	Rattus norvegicus	30-37
20347391-3	2010	Trigeminal nociceptors express the heat- and capsaicin-gated channel TRPV1, which seems to play a significant role in the development of peripheral and central sensitisation and of hyperalgesia and allodynia.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	69-74
19798065-7	2010	Dietary capsaicin lowered fasting glucose, insulin, leptin levels, and markedly reduced the impairment of glucose tolerance in obese mice.	Capsaicin	8-17	leptin	Mus musculus	52-58
19798065-10	2010	Moreover, luciferase assays revealed that capsaicin is capable of binding PPARalpha.	Capsaicin	42-51	peroxisome proliferator activated receptor alpha	Mus musculus	74-83
19798065-12	2010	The effects of capsaicin in adipose tissue and liver are related to its dual action on PPARalpha and TRPV-1 expression/activation.	Capsaicin	15-24	peroxisome proliferator activated receptor alpha	Mus musculus	87-96
19798065-12	2010	The effects of capsaicin in adipose tissue and liver are related to its dual action on PPARalpha and TRPV-1 expression/activation.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	101-107
19903464-0	2010	Block effect of capsaicin on hERG potassium currents is enhanced by S6 mutation at Y652.	Capsaicin	16-25	ETS transcription factor ERG	Homo sapiens	29-33
19903464-1	2010	The objectives of this study were to investigate the inhibitory action of capsaicin on wild-type (WT) and mutation human ether-a-go-go-related gene (hERG) potassium channel currents (I(hERG)), and to determine whether mutations in the S6 region are significant for the inhibition of I(hERG) by capsaicin.	Capsaicin	74-83	ETS transcription factor ERG	Homo sapiens	149-153
19903464-3	2010	The results show that capsaicin blocks WT hERG in a concentration-dependent manner, with an IC(50) of 17.45microM and a negative shift in the steady-state inactivation curve.	Capsaicin	22-31	ETS transcription factor ERG	Homo sapiens	42-46
19903464-7	2010	In conclusion, capsaicin blocks hERG channels by binding to both the closed and open channel states.Y652 was important as a molecular determinant of blockade.	Capsaicin	15-24	ETS transcription factor ERG	Homo sapiens	32-36
20038442-3	2010	To investigate this suggestion, we have studied intraplantar capsaicin injection-induced phosphorylation of extracellular signal-regulated kinase 1/2 in spinal dorsal horn neurons (which is a recognized marker of spinal nociceptive processing) in rat during isoflurane or sevoflurane anaesthesia after 60 min under anaesthesia.	Capsaicin	61-70	mitogen activated protein kinase 3	Rattus norvegicus	108-149
20038442-5	2010	Unilateral intraplantar capsaicin injection in control animals evoked extracellular signal-regulated kinase 1/2 phosphorylation in a group of neurons in lamina I and lamina II of the ipsilateral spinal dorsal horn in a somatotopically appropriate area.	Capsaicin	24-33	mitogen activated protein kinase 3	Rattus norvegicus	70-111
20038442-8	2010	Further, capsaicin injection into isoflurane-, or sevoflurane-, anaesthetized animals reduced extracellular signal-regulated kinase 1/2 phosphorylation induced by the gases alone on both sides.	Capsaicin	9-18	mitogen activated protein kinase 3	Rattus norvegicus	94-133
20388821-0	2010	Studies of the toxicological potential of capsinoids, XIII: inhibitory effects of capsaicin and capsinoids on cytochrome P450 3A4 in human liver microsomes.	Capsaicin	82-91	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	110-129
20388821-3	2010	Capsaicin clearly inhibited cytochrome P450 3A4 activity, losing 50% of the activity at 21.5 micromol/L.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	28-47
20388821-5	2010	Preincubation increased the capsaicin inhibitory activity against cytochrome P450 3A4 in a time-dependent manner.	Capsaicin	28-37	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-85
20388821-7	2010	Capsaicin was shown to inhibit cytochrome P450 3A4, probably through a mechanism-based inhibition.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	31-50
20535343-6	2010	Capsaicin can mediate a painful, burning sensation in the human gut via the transient receptor potential vanilloid-1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-116
20535343-6	2010	Capsaicin can mediate a painful, burning sensation in the human gut via the transient receptor potential vanilloid-1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
20006972-4	2010	In capsaicin-sensitive DRG neurons from wild-type mice, acid (>pH 5.0) evoked [Ca(2+)](i) increases, but not in DRG neurons from transient receptor potential V1 (TRPV1) (-/-) mice.	Capsaicin	3-12	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	165-170
20036240-0	2010	The effects of sympathetic outflow on upregulation of vanilloid receptors TRPV(1) in primary afferent neurons evoked by intradermal capsaicin.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	74-80
20036240-2	2010	Our recent study demonstrates that up-regulation of TRPV(1) receptors by intradermal injection of capsaicin is modulated by activation of the protein kinase C (PKC) cascade.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-58
20036240-4	2010	In a rat model of acute neurogenic inflammatory pain produced by capsaicin injection, we used immunofluorescence and Western blots combined with pharmacology and surgical sympathectomies to analyze whether the capsaicin-evoked up-regulation of TRPV(1) in DRG neurons is affected by sympathetic outflow by way of activating the PKC cascade.	Capsaicin	210-219	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	244-250
20036240-5	2010	Sympathetic denervation reduced significantly the capsaicin-evoked expressions of TRPV(1), calcitonin gene-related peptide and/or phosphorylated PKC and their co-expression.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	82-89
20036240-9	2010	Our findings suggest that the capsaicin-evoked up-regulation of TRPV(1) receptors in DRG neurons is modulated sympathetically by the action of ATP released from sympathetic efferents to activate the PKC cascade.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-70
19878665-1	2010	We recently demonstrated that SA13353 [1-[2-(1-adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea], a novel transient receptor potential vanilloid 1 (TRPV1) agonist, inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons.	Capsaicin	225-234	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	111-151
19879868-3	2010	It has been found that TRPV1 could be activated by endogenous ligands such as anandamide, N-arachidonoyl dopamine and N-oleoyldopamine or by exogenous agonists such as capsaicin and rutaecarpine.	Capsaicin	168-177	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-28
19944080-5	2010	The TRPV1 agonist capsaicin (CAP, 100 nM) was used to identify afferent, CAP-sensitive terminals arising from unmyelinated afferents.	Capsaicin	18-27	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
19448152-5	2010	N/OFQ significantly inhibited capsaicin-induced bronchoconstriction in both naive and sensitized mice, these latter animals displaying airway hyperresponsiveness to capsaicin.	Capsaicin	30-39	prepronociceptin	Mus musculus	0-5
19448152-5	2010	N/OFQ significantly inhibited capsaicin-induced bronchoconstriction in both naive and sensitized mice, these latter animals displaying airway hyperresponsiveness to capsaicin.	Capsaicin	165-174	prepronociceptin	Mus musculus	0-5
19448152-9	2010	We have demonstrated that a reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP receptor system in the modulation of capsaicin effects.	Capsaicin	110-119	prepronociceptin	Mus musculus	52-57
19448152-9	2010	We have demonstrated that a reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP receptor system in the modulation of capsaicin effects.	Capsaicin	110-119	prepronociceptin	Mus musculus	173-178
19448152-9	2010	We have demonstrated that a reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP receptor system in the modulation of capsaicin effects.	Capsaicin	110-119	crystallin, gamma B	Mus musculus	179-182
19448152-9	2010	We have demonstrated that a reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP receptor system in the modulation of capsaicin effects.	Capsaicin	220-229	prepronociceptin	Mus musculus	52-57
19448152-9	2010	We have demonstrated that a reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP receptor system in the modulation of capsaicin effects.	Capsaicin	220-229	prepronociceptin	Mus musculus	173-178
19448152-9	2010	We have demonstrated that a reduction in endogenous N/OFQ, or the lack of its receptor, causes an increase in capsaicin-induced bronchoconstriction, implying a role for the N/OFQ-NOP receptor system in the modulation of capsaicin effects.	Capsaicin	220-229	crystallin, gamma B	Mus musculus	179-182
19448152-10	2010	Moreover, for the first time, we document differential airway responsiveness to capsaicin between naive and sensitized mice due, at least in part, to decreased endogenous N/OFQ levels in sensitized mice.	Capsaicin	80-89	prepronociceptin	Mus musculus	171-176
19959817-2	2010	In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
19959817-2	2010	In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel.	Capsaicin	133-142	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
19959817-2	2010	In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel.	Capsaicin	133-142	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
19959817-3	2010	Capsaicin increased production of platelet activating factor (PAF), an important inflammatory mediator that acts as a chemoattractant and activator of immune cells.	Capsaicin	0-9	PCNA clamp associated factor	Homo sapiens	62-65
19959819-6	2010	Both lesion results and single-cell PCR results suggested that TRPA1 and TRPC1 were preferentially expressed in neurons that were either capsaicin sensitive or TRPV1 positive.	Capsaicin	137-146	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	63-68
19959819-6	2010	Both lesion results and single-cell PCR results suggested that TRPA1 and TRPC1 were preferentially expressed in neurons that were either capsaicin sensitive or TRPV1 positive.	Capsaicin	137-146	transient receptor potential cation channel, subfamily C, member 1	Rattus norvegicus	73-78
19399481-8	2010	Exposure to pollutants increased the TRPV1, NK(1) and NK(2) receptors gene expression in bronchus, an effect was partially suppressed by capsaicin treatment.	Capsaicin	137-146	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-42
20040737-2	2010	The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	79-119
20040737-2	2010	The vanilloid moiety of curcumin is considered important for activation of the transient receptor potential vanilloid 1 (TRPV1), which plays an important role in nociception.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-126
20040737-8	2010	Taken together, our results indicate that curcumin blocks capsaicin-induced TRPV1 activation and thereby inhibits TRPV1-mediated pain hypersensitivity.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
19740117-0	2010	Proteinase-activated receptor-2 activation evokes oesophageal longitudinal smooth muscle contraction via a capsaicin-sensitive and neurokinin-2 receptor-dependent pathway.	Capsaicin	107-116	F2R like trypsin receptor 1	Homo sapiens	0-31
19740117-10	2010	This suggests that acid-induced LSM contraction may involve mast cell-derived mediators that activate capsaicin-sensitive neurons via PAR-2.	Capsaicin	102-111	F2R like trypsin receptor 1	Homo sapiens	134-139
19896501-1	2010	The transient potential receptor vanilloid 1 (TRPV1) receptor is a non-selective cation channel that is chemically activated by capsaicin, the pungent component of hot peppers.	Capsaicin	128-137	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
20383941-8	2010	The inhibitory role of the selective alpha2 adrenoreceptor agonist clonidine on capsaicin-evoked SP release may be through decreasing VR1 mRNA levels then reducing the sensitivity of nociceptors to capsaicin.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-137
19958765-4	2010	In contrast, in TRPV1-transfected cells the inhibition was observed only when capsaicin or N-oleoyldopamine (OLDA, 10microM) was applied, but not when RTX, anandamide (AEA, 10microM) or pH 5.5 was used for gating.	Capsaicin	78-87	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	16-21
19958765-6	2010	Treatment of rTRPV1-expressing cells with sphinomyelinase inhibited the capsaicin-evoked (45)Ca-uptake leaving the RTX-induced response unchanged.	Capsaicin	72-81	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-19
20018876-3	2010	Behavioral studies showed greatly reduced thermal inflammatory pain perception in AQP1(-/-) mice evoked by bradykinin, prostaglandin E(2), and capsaicin as well as reduced cold pain perception.	Capsaicin	143-152	aquaporin 1	Mus musculus	82-86
19958811-1	2010	The transient receptor potential vanilloid-1 (TRPV1) receptor acts as a polymodal nociceptor activated by capsaicin, heat, and acid.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-44
19958811-1	2010	The transient receptor potential vanilloid-1 (TRPV1) receptor acts as a polymodal nociceptor activated by capsaicin, heat, and acid.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
19958811-2	2010	TRPV1, which is expressed in sensory neurons innervating the oral cavity, is associated with an oral burning sensation in response to spicy food containing capsaicin.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
19878665-6	2010	Capsaicin and SA13353 increased serum neuropeptide levels, and calcitonin gene-related peptide fragment 8-37 (CGRP(8)(-)(37)), a CGRP antagonist, partially blocked the inhibitory effects of capsaicin and SA13353 on LPS-induced TNF-alpha production.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	129-133
19878665-6	2010	Capsaicin and SA13353 increased serum neuropeptide levels, and calcitonin gene-related peptide fragment 8-37 (CGRP(8)(-)(37)), a CGRP antagonist, partially blocked the inhibitory effects of capsaicin and SA13353 on LPS-induced TNF-alpha production.	Capsaicin	0-9	tumor necrosis factor	Mus musculus	227-236
19878665-6	2010	Capsaicin and SA13353 increased serum neuropeptide levels, and calcitonin gene-related peptide fragment 8-37 (CGRP(8)(-)(37)), a CGRP antagonist, partially blocked the inhibitory effects of capsaicin and SA13353 on LPS-induced TNF-alpha production.	Capsaicin	190-199	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	110-114
19959817-2	2010	In fura-2 AM-loaded cells, the TRPV1 agonist capsaicin caused a fourfold cytosolic calcium increase, supporting a role of TRPV1 as a capsaicin-activated cation channel.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
19959817-4	2010	The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA(2), p38, and lyso-PAF acetyltransferase.	Capsaicin	213-222	mitogen-activated protein kinase 14	Homo sapiens	32-46
19959817-4	2010	The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA(2), p38, and lyso-PAF acetyltransferase.	Capsaicin	213-222	mitogen-activated protein kinase 14	Homo sapiens	32-35
19959817-4	2010	The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA(2), p38, and lyso-PAF acetyltransferase.	Capsaicin	213-222	phospholipase A2 group IVA	Homo sapiens	80-106
19959817-4	2010	The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA(2), p38, and lyso-PAF acetyltransferase.	Capsaicin	213-222	phospholipase A2 group IVA	Homo sapiens	108-115
19959817-4	2010	The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA(2), p38, and lyso-PAF acetyltransferase.	Capsaicin	213-222	lysophosphatidylcholine acyltransferase 1	Homo sapiens	147-173
19959817-4	2010	The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA(2), p38, and lyso-PAF acetyltransferase.	Capsaicin	213-222	PCNA clamp associated factor	Homo sapiens	152-155
19959817-4	2010	The increase was reduced by the p38 MAP kinase (p38) inhibitor SB203580, by the cytosolic phospholipase A2 (cPLA(2)) inhibitor AACOCF3, and by the lyso-PAF acetyltransferase inhibitor sanguinarin, indicating that capsaicin-induced PAF production may be mediated by activation of cPLA(2), p38, and lyso-PAF acetyltransferase.	Capsaicin	213-222	mitogen-activated protein kinase 14	Homo sapiens	48-51
19959817-6	2010	Capsaicin induced phosphorylation of p38 and cPLA(2).	Capsaicin	0-9	mitogen-activated protein kinase 14	Homo sapiens	37-40
19959817-6	2010	Capsaicin induced phosphorylation of p38 and cPLA(2).	Capsaicin	0-9	phospholipase A2 group IVA	Homo sapiens	45-52
19959817-7	2010	Capsaicin-induced p38 phosphorylation was not affected by AACOCF3.	Capsaicin	0-9	mitogen-activated protein kinase 14	Homo sapiens	18-21
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	12-21	phospholipase A2 group IVA	Homo sapiens	30-37
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	12-21	PCNA clamp associated factor	Homo sapiens	113-116
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	12-21	mitogen-activated protein kinase 14	Homo sapiens	164-167
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	12-21	phospholipase A2 group IVA	Homo sapiens	172-179
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	95-104	phospholipase A2 group IVA	Homo sapiens	30-37
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	95-104	PCNA clamp associated factor	Homo sapiens	113-116
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	95-104	mitogen-activated protein kinase 14	Homo sapiens	164-167
19959817-8	2010	Conversely, capsaicin-induced cPLA(2) phosphorylation was blocked by SB203580, indicating that capsaicin-induced PAF production depends on sequential activation of p38 and cPLA(2).	Capsaicin	95-104	phospholipase A2 group IVA	Homo sapiens	172-179
19959817-10	2010	p38 phosphorylation was stimulated by the calcium ionophore A23187 and by capsaicin, and the response to both agonists was reduced by a CaM inhibitor and by CaM-KII inhibitors, indicating that calcium induced activation of CaM and CaM-KII results in P38 phosphorylation.	Capsaicin	74-83	mitogen-activated protein kinase 14	Homo sapiens	0-3
19959817-10	2010	p38 phosphorylation was stimulated by the calcium ionophore A23187 and by capsaicin, and the response to both agonists was reduced by a CaM inhibitor and by CaM-KII inhibitors, indicating that calcium induced activation of CaM and CaM-KII results in P38 phosphorylation.	Capsaicin	74-83	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	231-238
19959817-10	2010	p38 phosphorylation was stimulated by the calcium ionophore A23187 and by capsaicin, and the response to both agonists was reduced by a CaM inhibitor and by CaM-KII inhibitors, indicating that calcium induced activation of CaM and CaM-KII results in P38 phosphorylation.	Capsaicin	74-83	mitogen-activated protein kinase 14	Homo sapiens	250-253
19959817-11	2010	Acetyl-CoA transferase activity increased in response to capsaicin and was inhibited by SB203580, indicating that p38 phosphorylation in turn causes activation of acetyl-CoA transferase to produce PAF.	Capsaicin	57-66	mitogen-activated protein kinase 14	Homo sapiens	114-117
19959817-11	2010	Acetyl-CoA transferase activity increased in response to capsaicin and was inhibited by SB203580, indicating that p38 phosphorylation in turn causes activation of acetyl-CoA transferase to produce PAF.	Capsaicin	57-66	PCNA clamp associated factor	Homo sapiens	197-200
20174488-0	2010	Capsaicin may slow PSA doubling time: case report and literature review.	Capsaicin	0-9	kallikrein related peptidase 3	Homo sapiens	19-22
19825380-2	2010	Evidence suggests pungent capsaicin-like TRPV1 activators also have broad inhibitory anti-emetic activity.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Mustela putorius furo	41-46
19570606-0	2010	Fas-associated factor 1 is a negative regulator in capsaicin induced cancer cell apoptosis.	Capsaicin	51-60	Fas associated factor 1	Homo sapiens	0-23
19570606-2	2010	Recent reports have demonstrated that tumor cells express TRPV1 and that capsaicin (CP), a ligand for TRPV1, induces apoptosis in cancer cells.	Capsaicin	73-82	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
21882462-49	2010	Cultured DRG neurons treated with NGF display enhanced inward current in response to application of the TRPV1 agonist capsaicin (Shu and Mendell 1999; Caterina et al.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	104-109
20031321-10	2010	C5a and C3a application elevated [Ca(2+)](i) and facilitated capsaicin-induced [Ca(2+)](i) responses in DRG neurons.	Capsaicin	61-70	hemolytic complement	Mus musculus	0-3
20857620-6	2010	Similarly, PGE2 does not exhibit gastric cytoprotection in EP1-receptor knockout mice, while capsaicin-induced protection is observed in animals lacking either EP1 receptors but disappears in IP-receptor knockout mice.	Capsaicin	93-102	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	160-163
20118549-1	2010	The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells).	Capsaicin	161-170	ATP binding cassette subfamily B member 1	Homo sapiens	96-110
20118549-1	2010	The present study was conducted to investigate the functional and transcriptional modulation of P-glycoprotein (MDR-1) by several dietary ingredients (piperine, capsaicin, daidzein, genistein, sesamin, curcumin, taurine) in vinblastine-resistant colon carcinoma LS-180 cells (LS-180V cells).	Capsaicin	161-170	ATP binding cassette subfamily B member 1	Homo sapiens	112-117
20118549-3	2010	These results suggest that the P-glycoprotein-mediated efflux is inhibited by piperine, capsaicin and sesamin and stimulated by daidzein and genistein.	Capsaicin	88-97	ATP binding cassette subfamily B member 1	Homo sapiens	31-45
20118549-4	2010	The concurrent addition of piperine and capsaicin seemed to inhibit synergistically the P-glycoprotein-mediated efflux.	Capsaicin	40-49	ATP binding cassette subfamily B member 1	Homo sapiens	88-102
20118549-8	2010	In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.	Capsaicin	151-160	ATP binding cassette subfamily C member 1	Homo sapiens	58-100
20118549-8	2010	In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.	Capsaicin	151-160	ATP binding cassette subfamily C member 1	Homo sapiens	102-106
20118549-8	2010	In LS-180V cells, significant increases in mRNA levels of multi-drug resistance associated protein 1 (MRP1) or MRP3 were observed on pretreatment with capsaicin, daidzein, piperine and sesamin.	Capsaicin	151-160	ATP binding cassette subfamily C member 3	Homo sapiens	111-115
20118549-10	2010	Also, capsaicin, daidzein, piperine and sesamin increased significantly the mRNA expression of MRP1 or MRP3.	Capsaicin	6-15	ATP binding cassette subfamily C member 1	Homo sapiens	95-99
20118549-10	2010	Also, capsaicin, daidzein, piperine and sesamin increased significantly the mRNA expression of MRP1 or MRP3.	Capsaicin	6-15	ATP binding cassette subfamily C member 3	Homo sapiens	103-107
20107070-3	2010	TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin).	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
20107070-3	2010	TRPV1 antagonists differentially block three modes of TRPV1 activation: by heat, protons, and chemical ligands (e.g., capsaicin).	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
19818386-0	2010	Sensitization of voltage activated calcium channel currents for capsaicin in nociceptive neurons by tumor-necrosis-factor-alpha.	Capsaicin	64-73	tumor necrosis factor	Rattus norvegicus	100-127
19818386-2	2010	This study examines whether TNF-alpha modulates the capsaicin-induced effects after transient receptor potential vanilloid (TRPV)-1 receptor activation on voltage activated calcium channel currents (I(Ca(V))).	Capsaicin	52-61	tumor necrosis factor	Rattus norvegicus	28-37
19818386-2	2010	This study examines whether TNF-alpha modulates the capsaicin-induced effects after transient receptor potential vanilloid (TRPV)-1 receptor activation on voltage activated calcium channel currents (I(Ca(V))).	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-131
19818386-4	2010	Eliciting I(Ca(V)) in DRG neurons of rats by a depolarization from the resting potential to 0 mV, TNF-alpha (100 ng/ml) reduces I(Ca(V)) by 16.9+/-2.2%, while capsaicin (0.1 microM) decreases currents by 27+/-4.3%.	Capsaicin	159-168	tumor necrosis factor	Rattus norvegicus	98-107
19818386-5	2010	Pre-application of TNF-alpha (100 ng/ml) for 24h results in a sensitization of I(Ca(V)) to capsaicin (0.1 microM) with a reduction of 42.8+/-4.4% mediated by TRPV-1.	Capsaicin	91-100	tumor necrosis factor	Rattus norvegicus	19-28
19818386-5	2010	Pre-application of TNF-alpha (100 ng/ml) for 24h results in a sensitization of I(Ca(V)) to capsaicin (0.1 microM) with a reduction of 42.8+/-4.4% mediated by TRPV-1.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	158-164
19818386-8	2010	Summarizing, TNF-alpha sensitizes nociceptive neurons for capsaicin.	Capsaicin	58-67	tumor necrosis factor	Rattus norvegicus	13-22
19855437-0	2010	Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.	Capsaicin	0-9	epidermal growth factor receptor	Homo sapiens	116-120
19855437-0	2010	Capsaicin causes cell-cycle arrest and apoptosis in ER-positive and -negative breast cancer cells by modulating the EGFR/HER-2 pathway.	Capsaicin	0-9	erb-b2 receptor tyrosine kinase 2	Homo sapiens	121-126
19855437-8	2010	Our data indicate that capsaicin is a novel modulator of the EGFR/HER-2 pathway in both ER-positive and -negative breast cancer cells with a potential role in the treatment and prevention of human breast cancer.	Capsaicin	23-32	epidermal growth factor receptor	Homo sapiens	61-65
19855437-8	2010	Our data indicate that capsaicin is a novel modulator of the EGFR/HER-2 pathway in both ER-positive and -negative breast cancer cells with a potential role in the treatment and prevention of human breast cancer.	Capsaicin	23-32	erb-b2 receptor tyrosine kinase 2	Homo sapiens	66-71
20639627-3	2010	Perfusion of capsaicin (CAP, 10(-6)M), a selective TRPV1 agonist, into the left renal pelvis increased ipsilateral ARNA in all groups, but with a smaller magnitude in DS-HS compared to other groups.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
20639627-3	2010	Perfusion of capsaicin (CAP, 10(-6)M), a selective TRPV1 agonist, into the left renal pelvis increased ipsilateral ARNA in all groups, but with a smaller magnitude in DS-HS compared to other groups.	Capsaicin	24-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
20686244-6	2010	The dose-response curves for TRPV1 activation by the essential oils revealed a rank order potency [the half-maximal effective concentration (EC(50))] of rose>palmarosa>thyme geraniol>tolu balsam, and rank order efficiency (% activity in response to 1 microM capsaicin) of tolu balsam>rose>palmarosa>thyme geraniol.	Capsaicin	267-276	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
19874332-0	2010	Neurotropin inhibits both capsaicin-induced substance P release and nerve growth factor-induced neurite outgrowth in cultured rat dorsal root ganglion neurones.	Capsaicin	26-35	tachykinin precursor 1	Homo sapiens	44-55
20378988-2	2010	We have reported that topical application of capsaicin increases facial skin elasticity by increasing the production of dermal insulin-like growth factor-I (IGF-I) through stimulation of sensory neurons in mice and humans.	Capsaicin	45-54	insulin-like growth factor 1	Mus musculus	127-155
20378988-2	2010	We have reported that topical application of capsaicin increases facial skin elasticity by increasing the production of dermal insulin-like growth factor-I (IGF-I) through stimulation of sensory neurons in mice and humans.	Capsaicin	45-54	insulin-like growth factor 1	Mus musculus	157-162
20078608-0	2010	Inhibition of capsaicin-induced increase in dermal blood flow by the oral CGRP receptor antagonist, telcagepant (MK-0974).	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	74-78
20078608-3	2010	* A novel pharmacodynamic assay to measure CGRP receptor antagonist activity non-invasively in humans has been developed, which involves measuring the increase in dermal blood flow induced by topical application of capsaicin on the forearm.	Capsaicin	215-224	calcitonin related polypeptide alpha	Homo sapiens	43-47
20078608-4	2010	WHAT THIS STUDY ADDS: * This study shows that the novel oral CGRP receptor antagonist, telcagepant, inhibits the increases in dermal blood flow induced by the topical application of capsaicin on the human forearm.	Capsaicin	182-191	calcitonin related polypeptide alpha	Homo sapiens	61-65
20078608-6	2010	AIMS: To evaluate inhibition of capsaicin-induced increase in dermal blood flow (DBF) following telcagepant (MK-0974), a potent and selective orally bioavailable calcitonin gene-related peptide (CGRP) receptor antagonist being developed for the acute treatment of migraine.	Capsaicin	32-41	calcitonin related polypeptide alpha	Homo sapiens	195-199
20166923-2	2010	These experiments were initially based on the observation that the endocannabinoid anandamide and the xenobiotic ligand of TRP channels of V1 type (TRPV1), capsaicin, are somehow chemically similar, both compounds being fatty acid amides, as are also synthetic activators of these channels and inhibitors of anandamide cellular re-uptake.	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Homo sapiens	148-153
20954075-5	2010	Capsaicin decreased the activation of extracellular signal-regulated kinases (ERK) without markedly affecting p38 kinases.	Capsaicin	0-9	mitogen-activated protein kinase 1	Mus musculus	38-76
19825429-0	2010	Capsaicin inhibits IFN-gamma-induced MHC class II expression by suppressing transcription of class II transactivator gene in murine peritoneal macrophages.	Capsaicin	0-9	interferon gamma	Mus musculus	19-28
19825429-0	2010	Capsaicin inhibits IFN-gamma-induced MHC class II expression by suppressing transcription of class II transactivator gene in murine peritoneal macrophages.	Capsaicin	0-9	class II transactivator	Mus musculus	93-116
19825429-3	2010	Capsaicin (0.1-10microM) reduced the expression of MHC class II mRNA levels in cultured peritoneal macrophages upon treatment with interferon (IFN)-gamma (100units/ml).	Capsaicin	0-9	interferon gamma	Mus musculus	131-153
19825429-4	2010	In agreement with this, treatment of the cells with capsaicin also inhibited MHC class II transactivator (CIITA) mRNA expression induced by IFN-gamma in a dose-dependent manner.	Capsaicin	52-61	class II transactivator	Mus musculus	77-104
19825429-4	2010	In agreement with this, treatment of the cells with capsaicin also inhibited MHC class II transactivator (CIITA) mRNA expression induced by IFN-gamma in a dose-dependent manner.	Capsaicin	52-61	class II transactivator	Mus musculus	106-111
19825429-4	2010	In agreement with this, treatment of the cells with capsaicin also inhibited MHC class II transactivator (CIITA) mRNA expression induced by IFN-gamma in a dose-dependent manner.	Capsaicin	52-61	interferon gamma	Mus musculus	140-149
19825429-5	2010	In contrast, production of nitric oxide, which has the ability to reduce MHC class II expression, was not enhanced but rather suppressed by capsaicin treatment in IFN-gamma-stimulated macrophages.	Capsaicin	140-149	interferon gamma	Mus musculus	163-172
19825429-6	2010	These findings suggest that capsaicin suppresses expression of MHC class II via downregulation of CIITA transcription but not through the mediation of nitric oxide production by macrophages.	Capsaicin	28-37	class II transactivator	Mus musculus	98-103
20686244-1	2010	Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel activated by capsaicin.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-48
20686244-1	2010	Transient receptor potential vanilloid subtype 1 (TRPV1) is a non-selective cation channel activated by capsaicin.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
19770677-1	2010	OBJECTIVES: Capsaicin/vanilloid (transient receptor potential vanilloid 1, (TRPV1) receptor has been shown to be expressed in gastrointestinal tract and play a role as a member of sensory ion channel superfamily.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
20954075-5	2010	Capsaicin decreased the activation of extracellular signal-regulated kinases (ERK) without markedly affecting p38 kinases.	Capsaicin	0-9	mitogen-activated protein kinase 1	Mus musculus	78-81
20954075-7	2010	Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.	Capsaicin	15-24	mitogen-activated protein kinase 1	Mus musculus	35-38
20954075-7	2010	Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.	Capsaicin	15-24	mitogen-activated protein kinase 1	Mus musculus	94-97
20954075-7	2010	Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.	Capsaicin	131-140	mitogen-activated protein kinase 1	Mus musculus	35-38
20954075-7	2010	Interestingly, capsaicin decreased ERK activation in the hippocampus, suggesting that reduced ERK signaling may be involved in the capsaicin-mediated regulation of hippocampal neurogenesis.	Capsaicin	131-140	mitogen-activated protein kinase 1	Mus musculus	94-97
19948377-6	2010	Infiltration of 0.05% capsaicin decreased CGRP and IB4/PGP9.5-immunoreactivity of nociceptors in skin.	Capsaicin	22-31	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
20407214-7	2010	The TRPV1 agonist capsaicin increased melatonin secretion from perifused pineals in a dose-dependent manner that was blocked by the competitive TRPV1 antagonist capsazepine.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
20407214-7	2010	The TRPV1 agonist capsaicin increased melatonin secretion from perifused pineals in a dose-dependent manner that was blocked by the competitive TRPV1 antagonist capsazepine.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-149
19948377-6	2010	Infiltration of 0.05% capsaicin decreased CGRP and IB4/PGP9.5-immunoreactivity of nociceptors in skin.	Capsaicin	22-31	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	55-61
19948377-10	2010	These putative TRPV1-expressing C-fibers are sensitized to heat and acid after incision, and the transduction of heat and chemical stimuli after plantar incision is impaired by dilute capsaicin.	Capsaicin	184-193	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	15-20
20187578-0	2010	Effects of acute exposure of alpha 1- and alpha 2-adrenoreceptor agonist or antagonist on capsaicin-evoked substance P release from dorsal root ganglion neurons in vitro.	Capsaicin	90-99	tachykinin precursor 1	Homo sapiens	107-118
19537933-4	2010	MCS-18 inhibited the increase in intracellular calcium concentration evoked in DRG neurons by capsaicin (300 nM) and low pH (5.5) but not by heat (43 degrees C).	Capsaicin	94-103	Mammary carcinoma susceptibility QTL 18	Rattus norvegicus	0-6
19537933-6	2010	Whole-cell patch-clamp was used to confirm the inhibition of capsaicin-induced currents by MCS-18 which was dose-dependent.	Capsaicin	61-70	Mammary carcinoma susceptibility QTL 18	Rattus norvegicus	91-97
19537933-8	2010	The antagonism of the capsaicin and proton action on native TRPV1 by MCS-18 may be of interest for pain therapy.	Capsaicin	22-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	60-65
19537933-8	2010	The antagonism of the capsaicin and proton action on native TRPV1 by MCS-18 may be of interest for pain therapy.	Capsaicin	22-31	Mammary carcinoma susceptibility QTL 18	Rattus norvegicus	69-75
20187578-7	2010	The data provided in the present study suggest that the excitatory effect of alpha 1-adrenoreceptor agonist on capsaicin-evoked release of neuropeptide from primary cultured DRG neurons is likely to be mediated by activation of VR1 to influence capsaicin sensitivity but not by promotion of SP synthesis under acute stimulative states.	Capsaicin	111-120	vault RNA 1-1	Homo sapiens	228-231
20187578-7	2010	The data provided in the present study suggest that the excitatory effect of alpha 1-adrenoreceptor agonist on capsaicin-evoked release of neuropeptide from primary cultured DRG neurons is likely to be mediated by activation of VR1 to influence capsaicin sensitivity but not by promotion of SP synthesis under acute stimulative states.	Capsaicin	245-254	vault RNA 1-1	Homo sapiens	228-231
19966466-0	2009	Non-pungent capsaicin analogs (capsinoids) increase metabolic rate and enhance thermogenesis via gastrointestinal TRPV1 in mice.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	114-119
19852938-6	2009	All the nesfatin-1-responsive neurons also exhibited [Ca(2+)](i) responses to capsaicin and cholecystokinin-8.	Capsaicin	78-87	nucleobindin 2	Mus musculus	8-18
19891501-5	2009	Glycolytic enzymes, namely, phosphoglycerate mutase (PGM) and triosephosphate isomerase (TPI), were overexpressed in capsaicin-treated Caco-2 cells.	Capsaicin	117-126	triosephosphate isomerase 1	Homo sapiens	62-87
19891501-5	2009	Glycolytic enzymes, namely, phosphoglycerate mutase (PGM) and triosephosphate isomerase (TPI), were overexpressed in capsaicin-treated Caco-2 cells.	Capsaicin	117-126	triosephosphate isomerase 1	Homo sapiens	89-92
19891501-6	2009	mRNA expression levels of TPI and PGM were also increased in capsaicin-treated Caco-2 cells.	Capsaicin	61-70	triosephosphate isomerase 1	Homo sapiens	26-29
19778582-1	2009	The transient receptor potential (TRP) vanilloid type 1 (TRPV1) agonist, capsaicin, enhances glutamatergic spontaneous excitatory synaptic transmission in CNS neurons.	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
19778582-8	2009	RTX activity could be blocked by capsazepine or SB-366791, a TRPV1 antagonist, but not tetrodotoxin, a Na(+)-channel blocker, and could be inhibited by pretreatment with capsaicin but not the TRPA1 agonist, allyl isothiocyanate.	Capsaicin	170-179	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
19778582-8	2009	RTX activity could be blocked by capsazepine or SB-366791, a TRPV1 antagonist, but not tetrodotoxin, a Na(+)-channel blocker, and could be inhibited by pretreatment with capsaicin but not the TRPA1 agonist, allyl isothiocyanate.	Capsaicin	170-179	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	192-197
19860742-9	2009	TRPV1 antagonist, capsazepine (10 microM) abolished capsaicin-evoked ATP release, and reduced acid-evoked (pH 6.5) release to 30% (P < 0.001).	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
19860742-12	2009	CONCLUSIONS AND IMPLICATIONS: Capsaicin (at TRPV1) and acid (at both TRPV1 and ASIC) induce ATP release from the rat bladder mucosa.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	44-49
19860742-12	2009	CONCLUSIONS AND IMPLICATIONS: Capsaicin (at TRPV1) and acid (at both TRPV1 and ASIC) induce ATP release from the rat bladder mucosa.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-74
19860742-12	2009	CONCLUSIONS AND IMPLICATIONS: Capsaicin (at TRPV1) and acid (at both TRPV1 and ASIC) induce ATP release from the rat bladder mucosa.	Capsaicin	30-39	acid sensing ion channel subunit 1	Rattus norvegicus	79-83
19130224-5	2009	Furthermore, SK-MS10 enhanced the mucosal expression of the CGRP gene and its serum levels.N(G)-methyl L-arginine (L-NMMA) or capsaicin desensitization reversed the SK-MS10-induced gastroprotection effect.	Capsaicin	126-135	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
19615927-11	2009	In the AP rats with capsaicin-deactivated sensory nerves GH failed to protect the pancreas against acute damage and, as a consequence of above deactivation, IGF-1 was low.	Capsaicin	20-29	gonadotropin releasing hormone receptor	Rattus norvegicus	57-59
19687471-1	2009	Somatostatin released from capsaicin-sensitive sensory nerves of the lung during endotoxin-induced murine pneumonitis inhibits inflammation and hyperresponsiveness, presumably via somatostatin receptor subtype 4 (sst(4)).	Capsaicin	27-36	somatostatin receptor 4	Mus musculus	180-211
19687471-1	2009	Somatostatin released from capsaicin-sensitive sensory nerves of the lung during endotoxin-induced murine pneumonitis inhibits inflammation and hyperresponsiveness, presumably via somatostatin receptor subtype 4 (sst(4)).	Capsaicin	27-36	somatostatin receptor 4	Mus musculus	213-219
19773532-9	2009	These data demonstrate that E(2) mediates the female"s enhanced sensitivity to capsaicin-induced acute pain, consistent with potentiation by E(2) of the capsaicin receptor-mediated current in rat DRG neurons.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	153-171
19846148-8	2009	Capsaicin (100 nM and 1 microM) and heat (41C and 45C) evoked cobalt uptake and inflammatory mediators lowered the temperature threshold for TRPV1 activation to 37C.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	141-146
19846148-9	2009	Capsaicin (1 microM) induced TRPV1 desensitization to further applications of the agonist.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
19846148-12	2009	CONCLUSIONS: TRPV1 receptors expressed by human urothelial cells respond to capsaicin and thermal stimuli.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
19846148-13	2009	Capsaicin evoked release of adenosine triphosphate suggests that human urothelial TRPV1 is involved in the afferent branch of the micturition reflex.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
20054487-0	2009	The Antinociceptive Effect of Sigma-1 Receptor Antagonist, BD1047, in a Capsaicin Induced Headache Model in Rats.	Capsaicin	72-81	sigma non-opioid intracellular receptor 1	Rattus norvegicus	30-46
20162407-4	2009	Capsaicin and low pH induced significant increases in CGRP release which was shown to be mediated by TRPV1 activation as demonstrated with the TRPV1 antagonists CTPC and capsazepine.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	54-58
20162407-4	2009	Capsaicin and low pH induced significant increases in CGRP release which was shown to be mediated by TRPV1 activation as demonstrated with the TRPV1 antagonists CTPC and capsazepine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-106
20162407-4	2009	Capsaicin and low pH induced significant increases in CGRP release which was shown to be mediated by TRPV1 activation as demonstrated with the TRPV1 antagonists CTPC and capsazepine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	143-148
20162407-7	2009	We conclude that CGRP release in the rat distal colon occurs in response to mast cell degranulation, inflammatory mediators, low pH and capsaicin and describe a role for TRPV1 receptors in mediating the response.	Capsaicin	136-145	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
19767149-2	2009	For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation by capsaicin and heat.	Capsaicin	176-185	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	8-52
19767149-2	2009	For the Transient Receptor Potential family V type 1 (TRPV1) receptor, phosphorylation of certain serine/threonine amino acid residues sensitizes the receptor to activation by capsaicin and heat.	Capsaicin	176-185	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
19767149-8	2009	Employing siRNA-mediated knock-down of AKAP150 expression, we demonstrate that PKC-mediated phosphorylation of TRPV1 and sensitization to a capsaicin response is dependent upon functional expression of the AKAP150 scaffolding protein.	Capsaicin	140-149	A-kinase anchoring protein 5	Rattus norvegicus	39-46
19767149-8	2009	Employing siRNA-mediated knock-down of AKAP150 expression, we demonstrate that PKC-mediated phosphorylation of TRPV1 and sensitization to a capsaicin response is dependent upon functional expression of the AKAP150 scaffolding protein.	Capsaicin	140-149	protein kinase C, gamma	Rattus norvegicus	79-82
19767149-8	2009	Employing siRNA-mediated knock-down of AKAP150 expression, we demonstrate that PKC-mediated phosphorylation of TRPV1 and sensitization to a capsaicin response is dependent upon functional expression of the AKAP150 scaffolding protein.	Capsaicin	140-149	A-kinase anchoring protein 5	Rattus norvegicus	206-213
19333140-0	2009	Prophylactic proopiomelanocortin expression alleviates capsaicin-induced neurogenic inflammation in rat trachea.	Capsaicin	55-64	proopiomelanocortin	Rattus norvegicus	13-32
19333140-4	2009	The present study aimed to evaluate whether peripheral POMC expression ameliorated capsaicin-induced acute neurogenic inflammation in rat trachea.	Capsaicin	83-92	proopiomelanocortin	Rattus norvegicus	55-59
19333140-7	2009	The extent of capsaicin-evoked plasma leakage in trachea was alleviated in Ad-POMC-treated rats compared with animals of control groups (P < 0.01).	Capsaicin	14-23	proopiomelanocortin	Rattus norvegicus	78-82
19778904-4	2009	Activation of TRPV1(ER) with capsaicin or other vanilloids produced an increase of cytosolic Ca(2+) due to Ca(2+) release from the ER.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
19540328-6	2009	The response was quantified as the product induced Ca(2+) influx during 2 min in relation to the maximum response induced by the TRPV1 agonist capsaicin.	Capsaicin	143-152	transient receptor potential cation channel subfamily V member 1	Homo sapiens	129-134
19778904-7	2009	The low affinity of TRPV1(ER) was not related to protein kinase A- or C-mediated phosphorylations, but it was due to inactivation by cytosolic Ca(2+) because the sensitivity to capsaicin was increased by loading the cells with the Ca(2+) chelator BAPTA.	Capsaicin	177-186	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
19778904-6	2009	The sensitivity of TRPV1(ER) to capsaicin was smaller than the sensitivity of the plasma membrane TRPV1 channels.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-24
19778904-9	2009	Disruption of the TRPV1 calmodulin-binding domains at either the C terminus (Delta35AA) or the N terminus (K155A) increased 10-fold the affinity of TRPV1(ER) for capsaicin, suggesting that calmodulin is involved in the inactivation.	Capsaicin	162-171	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
19845671-5	2009	KEY RESULTS: Inhalation of two selective TRPA1 agonists, allyl isothiocyanate and cinnamaldehyde, dose-dependently caused cough in control guinea pigs, but not in those with airway sensory nerves desensitized by capsaicin.	Capsaicin	212-221	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	41-46
19778904-9	2009	Disruption of the TRPV1 calmodulin-binding domains at either the C terminus (Delta35AA) or the N terminus (K155A) increased 10-fold the affinity of TRPV1(ER) for capsaicin, suggesting that calmodulin is involved in the inactivation.	Capsaicin	162-171	calmodulin 1	Homo sapiens	24-34
19778904-9	2009	Disruption of the TRPV1 calmodulin-binding domains at either the C terminus (Delta35AA) or the N terminus (K155A) increased 10-fold the affinity of TRPV1(ER) for capsaicin, suggesting that calmodulin is involved in the inactivation.	Capsaicin	162-171	transient receptor potential cation channel subfamily V member 1	Homo sapiens	148-153
19778904-10	2009	The lack of TRPV1 sensitizers, such as phosphatidylinositol 4,5-bisphosphate, in the ER could contribute to decrease the affinity for capsaicin.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
19737844-6	2009	In comparison with vehicle infusion or the non-injected side of the face, capsaicin significantly increased the expression of the activation markers Fos in the spinal trigeminal nucleus and phosphorylated extracellular signal-regulated kinase in the trigeminal ganglion.	Capsaicin	74-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	149-152
19737844-7	2009	Pre-treatment with olcegepant (900 microg/kg) inhibited the capsaicin-induced expression of Fos throughout the spinal trigeminal nucleus by 57%.	Capsaicin	60-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-95
19845671-9	2009	CONCLUSIONS AND IMPLICATIONS: A novel pro-tussive pathway involves the TRPA1 channel, expressed by capsaicin-sensitive airway sensory nerves and is activated by a series of exogenous (cigarette smoke) and endogenous irritants.	Capsaicin	99-108	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	71-76
19553628-0	2009	Pigment epithelium-derived factor (PEDF) attenuated capsaicin-induced neurotrophic keratouveitis.	Capsaicin	52-61	serpin family F member 1	Rattus norvegicus	0-33
19553628-0	2009	Pigment epithelium-derived factor (PEDF) attenuated capsaicin-induced neurotrophic keratouveitis.	Capsaicin	52-61	serpin family F member 1	Rattus norvegicus	35-39
19553628-6	2009	RESULTS: Reduced tear secretion was found in capsaicin-treated rats compared with the control, but this effect was significantly attenuated by PEDF.	Capsaicin	45-54	serpin family F member 1	Rattus norvegicus	143-147
19553628-7	2009	Corneal ulceration developed and was followed by scar formation and neovascularization in the capsaicin-treated, and it was also significantly attenuated by PEDF treatment.	Capsaicin	94-103	serpin family F member 1	Rattus norvegicus	157-161
19553628-8	2009	Leukocyte infiltration of the anterior and posterior chambers, as well as the peripheral retina and vitreous, was also observed in capsaicin-treated eyes and was significantly reduced by PEDF treatment.	Capsaicin	131-140	serpin family F member 1	Rattus norvegicus	187-191
19553628-10	2009	CONCLUSIONS: PEDF accelerated the recovery of tear secretion and also prevented capsaicin-induced neurotrophic keratouveitis and peripheral vitreoretinal inflammation.	Capsaicin	80-89	serpin family F member 1	Rattus norvegicus	13-17
19761536-4	2009	cough-reflex sensitivity was evaluated using the log concentration of capsaicin causing five or more coughs (log C(5)).	Capsaicin	70-79	complement C5	Homo sapiens	113-117
19654265-13	2009	These data demonstrate that capsaicin interacts with TRPV1 receptors on MNEs to reduce BoNT/A uptake via a Ca(2+)-dependent mechanism.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	53-58
19699254-4	2009	Capsaicin also induced degradation of tumor suppressor p53; this effect was enhanced by the ER stressor tunicamycin.	Capsaicin	0-9	tumor protein p53	Homo sapiens	55-58
19699254-5	2009	The proteasome inhibitor MG132 completely blocked capsaicin-induced p53 degradation and enhanced apoptotic cell death.	Capsaicin	50-59	tumor protein p53	Homo sapiens	68-71
19699254-6	2009	Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.	Capsaicin	0-9	DNA damage inducible transcript 3	Homo sapiens	78-82
19699254-6	2009	Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.	Capsaicin	0-9	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	64-68
19699254-6	2009	Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.	Capsaicin	0-9	heat shock protein family A (Hsp70) member 5	Homo sapiens	84-89
19699254-6	2009	Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.	Capsaicin	0-9	heat shock protein family A (Hsp70) member 5	Homo sapiens	90-93
19699254-6	2009	Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.	Capsaicin	0-9	DNA damage inducible transcript 3	Homo sapiens	70-77
19699254-6	2009	Capsaicin treatment triggered ER stress by increasing levels of IRE1, GADD153/Chop, GRP78/Bip, and activated caspase-4.	Capsaicin	0-9	caspase 4	Homo sapiens	109-118
19828806-5	2009	This was associated with increased calcium influx and increased inward currents in small- and medium-sized primary sensory neurons of SNS-IKKbeta(-/-) mice during stimulation with capsaicin or Formalin, specific activators of transient receptor potentials TRPV1 and TRPA1 calcium channels, respectively.	Capsaicin	180-189	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	266-271
19699254-8	2009	Furthermore, capsaicin-induced the mitochondrial apoptotic pathway through calpain-mediated Bid translocation to the mitochondria and nuclear translocation of apoptosis-inducing factor (AIF).	Capsaicin	13-22	BH3 interacting domain death agonist	Homo sapiens	92-95
19699254-9	2009	Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.	Capsaicin	0-9	caspase 9	Homo sapiens	18-27
19699254-9	2009	Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.	Capsaicin	0-9	BH3 interacting domain death agonist	Homo sapiens	29-32
19699254-9	2009	Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.	Capsaicin	0-9	BH3 interacting domain death agonist	Homo sapiens	150-153
19887740-6	2009	In addition, after capsaicin treatment, numbers of AgRP- and orexin-immunoreactive ((+)) cells were significantly decreased in the arcuate nucleus (ARC) and lateral hypothalamic area, respectively.	Capsaicin	19-28	hypocretin neuropeptide precursor	Rattus norvegicus	61-67
19661152-8	2009	Capsaicin treatment on esophageal vagal trunks abolished the GLP-1 secretion induced by duodenal ZeinH but did not affect the secretion induced by jejunal or ileal ZeinH.	Capsaicin	0-9	glucagon	Rattus norvegicus	61-66
19846903-3	2009	Capsaicin and resveratrol, alone or in combination, inhibited cell growth and promoted apoptosis by the elevation of NO; combined treatment in p53-WT cells was most effective.	Capsaicin	0-9	tumor protein p53	Homo sapiens	143-146
19846903-7	2009	These findings provide insight into the mechanism of apoptotic action of capsaicin and resveratrol based on p53 status and indicate manipulation of NO may offer exciting opportunities to improve the effectiveness of colon cancer treatment.	Capsaicin	73-82	tumor protein p53	Homo sapiens	108-111
19619644-1	2009	Transient receptor potential vanilloid (TRPV) 1 channels function as sensors for a variety of noxious and inflammatory signals, including capsaicin, heat and protons, and are up-regulated under inflammatory conditions.	Capsaicin	138-147	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-47
19628632-8	2009	Conversely, contractile responses to ET-1 were, compared with PHE, hypersensitive to the relaxing effects of the TRPV1-agonist capsaicin and to exogenous CGRP, but not to acetylcholine, forskolin, pinacidil, or SNP.	Capsaicin	127-136	endothelin 1	Rattus norvegicus	37-41
19628632-8	2009	Conversely, contractile responses to ET-1 were, compared with PHE, hypersensitive to the relaxing effects of the TRPV1-agonist capsaicin and to exogenous CGRP, but not to acetylcholine, forskolin, pinacidil, or SNP.	Capsaicin	127-136	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	113-118
19764982-2	2009	In view of the effects of cannabinoids in a thioacetamide-induced model of hepatic encephalopathy and liver disease and the beneficial effect of capsaicin (a TRPV1 agonist) in liver disease, we assumed that capsaicin may also affect hepatic encephalopathy.	Capsaicin	145-154	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	158-163
19887740-6	2009	In addition, after capsaicin treatment, numbers of AgRP- and orexin-immunoreactive ((+)) cells were significantly decreased in the arcuate nucleus (ARC) and lateral hypothalamic area, respectively.	Capsaicin	19-28	agouti related neuropeptide	Rattus norvegicus	51-56
19887740-7	2009	In contrast, the number of alpha-MSH(+) and ACTH(+) cells in the ARC of the capsaicin-treated rats was higher than in the vehicle-treated rats.	Capsaicin	76-85	proopiomelanocortin	Rattus norvegicus	27-36
19887740-8	2009	These results indicate that capsaicin reduces food intake, not body weight, transiently, and decreases AgRP and orexin immunoreactivities, whereas it increases alpha-MSH and ACTH immunoreactivities in rat hypothalamic nuclei.	Capsaicin	28-37	agouti related neuropeptide	Rattus norvegicus	103-107
19887740-8	2009	These results indicate that capsaicin reduces food intake, not body weight, transiently, and decreases AgRP and orexin immunoreactivities, whereas it increases alpha-MSH and ACTH immunoreactivities in rat hypothalamic nuclei.	Capsaicin	28-37	hypocretin neuropeptide precursor	Rattus norvegicus	112-118
19887740-8	2009	These results indicate that capsaicin reduces food intake, not body weight, transiently, and decreases AgRP and orexin immunoreactivities, whereas it increases alpha-MSH and ACTH immunoreactivities in rat hypothalamic nuclei.	Capsaicin	28-37	proopiomelanocortin	Rattus norvegicus	160-169
19852757-3	2009	TRPV1, also known as the vanilloid receptor (VR1), is activated by ligands such as capsaicin, acidic pH, and heat (an increase in temperature to approximately 42 degrees C will lead to channel opening).	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
19566590-3	2009	Exposure of TRPV(1) to capsaicin is characterized by activation, followed by desensitization.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-19
19566590-12	2009	Oesophageal instillation of the TRPV(1) receptor agonist capsaicin induces symptoms of retrosternal and epigastric burning in a dose-dependent fashion.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-39
19482068-7	2009	Capsaicin or menthol and cooling modulated both sacrocaudal afferent (SCA) evoked and monoaminergic drug-induced rhythmic locomotor-like activity in spinal cords from wild type but not TRPV1-null (trpv1(-/-)) or TRPM8-null (trpm8(-/-)) mice, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	197-202
19482068-7	2009	Capsaicin or menthol and cooling modulated both sacrocaudal afferent (SCA) evoked and monoaminergic drug-induced rhythmic locomotor-like activity in spinal cords from wild type but not TRPV1-null (trpv1(-/-)) or TRPM8-null (trpm8(-/-)) mice, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	212-217
19482068-7	2009	Capsaicin or menthol and cooling modulated both sacrocaudal afferent (SCA) evoked and monoaminergic drug-induced rhythmic locomotor-like activity in spinal cords from wild type but not TRPV1-null (trpv1(-/-)) or TRPM8-null (trpm8(-/-)) mice, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	224-229
19486928-3	2009	Capsaicin treatment, but not vehicle, resulted in a significant (>70%) depletion in the density of calcitonin-gene related peptide positive (CGRP(+)) sensory nerve fibers, but not 200 kDa neurofilament H positive (NF200(+)) sensory nerve fibers in the periosteum.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	144-148
19486928-6	2009	These results suggest that both capsaicin-sensitive (primarily CGRP(+) C-fibers) and capsaicin-insensitive (primarily NF200(+) A-delta fibers) sensory nerve fibers participate in driving skeletal fracture pain.	Capsaicin	32-41	calcitonin related polypeptide alpha	Homo sapiens	63-67
19562439-9	2009	Unidentified isolectin B4 (IB4)-positive but TRPV1-negative small neurons with a higher noxious heat threshold are feasible, because a spliced isoform of TRPV1 responsive to noxious heat (47 degrees C) but not responsive to either proton or capsaicin is present in human and rat sensory neurons.	Capsaicin	241-250	transient receptor potential cation channel subfamily V member 1	Homo sapiens	154-159
19852757-3	2009	TRPV1, also known as the vanilloid receptor (VR1), is activated by ligands such as capsaicin, acidic pH, and heat (an increase in temperature to approximately 42 degrees C will lead to channel opening).	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-48
19628434-11	2009	Capsaicin increased mechanical responses in the nestin/hRAMP1 and control mice, although a higher dose was required in controls.	Capsaicin	0-9	receptor activity modifying protein 1	Homo sapiens	55-61
19483072-7	2009	HCl-induced vasodilation was inhibited by cold-storage denervation, capsazepine, capsaicin (CGRP depletor), and CGRP(8-37) (CGRP receptor antagonist).	Capsaicin	81-90	calcitonin-related polypeptide alpha	Rattus norvegicus	92-96
19904003-5	2009	For the most active derivative of dihydrofuran-2-one, L-PP1 (3-[4-(3-trifluoromethylphenyl)-piperazin-1-yl]-dihydrofuran-2-one dihydrochloride), the ED(50) value was: 1.34 mg/kg, 0.79 mg/kg, 2.01 mg/kg and 3.99 mg/kg in the hot plate, writhing, capsaicin- and glutamate-induced pain tests, respectively.	Capsaicin	245-254	phospholipid phosphatase 1	Mus musculus	54-59
19491327-0	2009	Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.	Capsaicin	38-47	calcitonin related polypeptide alpha	Homo sapiens	55-86
19491327-0	2009	Sustained morphine treatment augments capsaicin-evoked calcitonin gene-related peptide release from primary sensory neurons in a protein kinase A- and Raf-1-dependent manner.	Capsaicin	38-47	Raf-1 proto-oncogene, serine/threonine kinase	Homo sapiens	151-156
19477951-9	2009	TRPV1 channel activation with capsaicin failed to activate ERK.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
19520130-6	2009	alone did not alter capsaicin-induced nociception, whereas substance P at a higher dose of 100 pmol significantly reduced the capsaicin response.	Capsaicin	126-135	tachykinin 1	Mus musculus	59-70
19520130-8	2009	The N-terminal fragment of substance P (1-7), which is known as a major product of substance P by endopeptidase-24.11, was more effective than substance P on capsaicin-induced nociception.	Capsaicin	158-167	tachykinin 1	Mus musculus	27-38
19695100-4	2009	TNF-alpha pre-treatment (1 ng/ml, 8-16 hr) significantly increases (doubles) capsaicin responsive cell numbers and [Ca2+]i spike frequency, as well as enhances average amplitude of temperature induced [Ca2+]i responses.	Capsaicin	77-86	tumor necrosis factor	Homo sapiens	0-9
19473323-0	2009	Functional loss of pAMT results in biosynthesis of capsinoids, capsaicinoid analogs, in Capsicum annuum cv.	Capsaicin	63-75	gamma aminobutyrate transaminase 2	Capsicum annuum	19-23
19473323-6	2009	We analyzed the putative aminotransferase (pAMT) that is thought to catalyze the formation of vanillylamine from vanillin in the capsaicinoid biosynthetic pathway.	Capsaicin	129-141	gamma aminobutyrate transaminase 2	Capsicum annuum	43-47
19473323-10	2009	We developed a dCAPS marker based on the T insertion in the pAMT gene of CH-19 Sweet, and showed that the pAMT genotype co-segregated with the capsinoid or capsaicinoid fruit phenotype in the F(2) population.	Capsaicin	156-168	gamma aminobutyrate transaminase 2	Capsicum annuum	106-110
19695100-3	2009	RESULTS: Fluorescent imaging of Fura-2 loaded human SW982 synoviocytes reveals immediate and delayed cytosolic calcium oscillations elicited by (1) TRPV1 agonists capsaicin and resiniferatoxin (20-40% of cells), (2) moderate and noxious temperature change, and (3) osmotic stress TRPV4 activation (11.5% of cells).	Capsaicin	163-172	transient receptor potential cation channel subfamily V member 1	Homo sapiens	148-153
19285756-2	2009	Three of them were capsinoids with different acyl chain compared with capsaicin after substitution of ester for amide at C(1) position.	Capsaicin	70-79	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	121-125
19497956-8	2009	The capsaicin-induced transient contraction from the proximal colon to the rectum was moderately inhibited by an NK1 or NK2 receptor antagonist.	Capsaicin	4-13	killer cell lectin-like receptor subfamily B member 1C	Mus musculus	113-116
19497956-8	2009	The capsaicin-induced transient contraction from the proximal colon to the rectum was moderately inhibited by an NK1 or NK2 receptor antagonist.	Capsaicin	4-13	tachykinin receptor 2	Mus musculus	120-132
19497956-9	2009	The capsaicin-induced long-lasting contraction in the rectum and distal colon was markedly inhibited by an NK2 antagonist, but not by an NK1 antagonist.	Capsaicin	4-13	killer cell lectin-like receptor, subfamily A, member 3	Mus musculus	107-110
19723084-4	2009	The combined effects of genistein and capsaicin on COX-2, pJNK, pERK, and pp38 expressions were additive or nonadditive, depending on signals tested.	Capsaicin	38-47	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	51-56
19723084-7	2009	AMPK activation by genistein in combination with capsaicin is critical for inhibiting COX-2.	Capsaicin	49-58	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	86-91
19723084-8	2009	We propose that genistein in combination with capsaicin exerts anti-inflammatory and anticarcinogenic properties through the modulation of AMPK and COX-2 and possibly various mitogen-activated protein kinases synergistically or nonsynergistically.	Capsaicin	46-55	protein kinase AMP-activated catalytic subunit alpha 2	Rattus norvegicus	139-143
19723084-8	2009	We propose that genistein in combination with capsaicin exerts anti-inflammatory and anticarcinogenic properties through the modulation of AMPK and COX-2 and possibly various mitogen-activated protein kinases synergistically or nonsynergistically.	Capsaicin	46-55	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	148-153
19524560-6	2009	Moreover, BDNF treatment increased the amplitude of the response to both AITC and capsaicin.	Capsaicin	82-91	brain-derived neurotrophic factor	Rattus norvegicus	10-14
19502594-0	2009	Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-59
19502594-0	2009	Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
19502594-0	2009	Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.	Capsaicin	71-80	Fas cell surface death receptor	Homo sapiens	93-97
19502594-0	2009	Triggering of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin induces Fas/CD95-mediated apoptosis of urothelial cancer cells in an ATM-dependent manner.	Capsaicin	71-80	ATM serine/threonine kinase	Homo sapiens	150-153
19502594-1	2009	Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS).	Capsaicin	211-220	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-94
19502594-1	2009	Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS).	Capsaicin	211-220	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-101
19502594-1	2009	Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS).	Capsaicin	222-225	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-94
19502594-1	2009	Herein, we provide evidence on the expression of transient receptor potential vanilloid type 1 (TRPV1) on human urothelial cancer (UC) cells and its involvement in the apoptosis induced by the selective agonist capsaicin (CPS).	Capsaicin	222-225	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-101
19502594-5	2009	CPS induced Fas/CD95 upregulation, but more importantly Fas/CD95 ligand independent, TRPV1-dependent death receptor clustering and triggering of both extrinsic and intrinsic mitochondrial-dependent pathways.	Capsaicin	0-3	Fas cell surface death receptor	Homo sapiens	16-20
19502594-6	2009	Moreover, we observed that CPS activates ATM kinase that is involved in Ser15, Ser20 and Ser392 p53 phosphorylation as shown by the use of the specific inhibitor KU55933.	Capsaicin	27-30	ATM serine/threonine kinase	Homo sapiens	41-44
19502594-6	2009	Moreover, we observed that CPS activates ATM kinase that is involved in Ser15, Ser20 and Ser392 p53 phosphorylation as shown by the use of the specific inhibitor KU55933.	Capsaicin	27-30	tumor protein p53	Homo sapiens	96-99
19285756-3	2009	The other three could be described as capsinoid derivatives with different alkoxy chain, compared with capsaicin after substitution of ester for amide at C(1) position and alkoxy for hydroxy at C(4) position and synthesis of them was reported first.	Capsaicin	103-112	heterogeneous nuclear ribonucleoprotein C	Homo sapiens	154-158
19298229-6	2009	capsazepine, the selective TRPV1 antagonist SB-705498, neomycin or vehicle alone and 30 min later instilled with intracolonic TRPV1-activating capsaicin.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	126-131
19326358-2	2009	To test if enteric afferent nerves are of importance for the development of chronic colitis, we examined antagonists for the high-affinity neurokinin 1 (NK-1) SP receptor and the TRPV1 receptor agonist capsaicin in a T-cell transfer model for chronic colitis.	Capsaicin	202-211	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	179-184
19326358-7	2009	Capsaicin-induced depletion of nociceptive afferent nerves prior to CD4(+)CD25(-) T-cell transfer completely inhibited the development of colitis.	Capsaicin	0-9	CD4 antigen	Mus musculus	68-71
19583679-2	2009	Genetic variations in the neurokinin 2 receptor gene (NK2R) are significantly associated with cough sensitivity to capsaicin.	Capsaicin	115-124	tachykinin receptor 2	Homo sapiens	26-47
19583679-2	2009	Genetic variations in the neurokinin 2 receptor gene (NK2R) are significantly associated with cough sensitivity to capsaicin.	Capsaicin	115-124	tachykinin receptor 2	Homo sapiens	54-58
19460365-0	2009	Spinal sumatriptan inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors.	Capsaicin	28-37	5-hydroxytryptamine receptor 1B	Canis lupus familiaris	89-95
19460365-13	2009	These results suggest that sumatriptan-induced inhibition of the external carotid vasodilatation to capsaicin involves a central mechanism mainly mediated by 5-HT(1B) receptors.	Capsaicin	100-109	5-hydroxytryptamine receptor 1B	Canis lupus familiaris	158-165
19622238-4	2009	Real-time RT-PCR analysis revealed decreased expression of sweet receptors T1R2 and T1R3 as well as capsaicin receptor VR1 in the circumvallate after this repeated oral exposure to capsaicin.	Capsaicin	100-109	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	119-122
19635294-11	2009	For D2 gubernacula, capsaicin treatment increased apoptosis compared to controls, without CGRP added (4.9% vs 7.3%, P < .05) and with CGRP (2.3% vs 6.7%, P < .001).	Capsaicin	20-29	calcitonin-related polypeptide alpha	Rattus norvegicus	137-141
19635294-17	2009	However, in vivo CGRP released from the genitofemoral nerve may be required to prevent apoptosis, as shown by pretreatment with the sensory nerve toxin capsaicin.	Capsaicin	152-161	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
19629004-3	2009	Calcitonin gene-related peptide liberation is stimulated by capsaicin, a substance of red hot chili peppers.	Capsaicin	60-69	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
19629004-14	2009	Calcitonin gene-related peptide increased in both capsaicin groups, indicating endogenous CGRP liberation (P<0.01).	Capsaicin	50-59	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
19629004-14	2009	Calcitonin gene-related peptide increased in both capsaicin groups, indicating endogenous CGRP liberation (P<0.01).	Capsaicin	50-59	calcitonin-related polypeptide alpha	Rattus norvegicus	90-94
19629004-15	2009	CONCLUSION: Capsaicin releases endogenous CGRP with improved pancreatic microcirculation and reduced inflammation in experimental AP.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
19464796-5	2009	Pretreatment of the muscle with a TRPV1 antagonist, capsazepine, effectively attenuated the capsaicin-induced muscle nociception and mechanical hyperalgesia.	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	34-39
19622238-7	2009	Also, these data suggest that capsaicin may interact with a sweet transduction pathway in the mediation of its receptor VR1 that are located in the vallate taste cells.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-123
19595440-3	2009	In the current study, we examined whether stimulation of sensory neurons by capsaicin improved the cognitive function by increasing the production of IGF-I in the hippocampus using wild-type (WT) and CGRP-knockout (CGRP-/-) mice.	Capsaicin	76-85	insulin-like growth factor 1	Mus musculus	150-155
19595440-4	2009	Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.	Capsaicin	122-131	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	58-62
19595440-4	2009	Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.	Capsaicin	122-131	insulin-like growth factor 1	Mus musculus	64-69
19595440-4	2009	Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.	Capsaicin	122-131	insulin-like growth factor 1	Mus musculus	75-80
19595440-4	2009	Significant increases of the hippocampal tissue levels of CGRP, IGF-I, and IGF-I messenger RNA (mRNA) were observed after capsaicin administration in WT mice (P < 0.01) but not in CGRP-/- mice.	Capsaicin	122-131	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	183-187
19595440-5	2009	Increase in the expression of c-fos was also observed in the spinal dorsal horn, the parabrachial nuclei, and the hippocampus after capsaicin administration in WT mice but not in CGRP-/- mice.	Capsaicin	132-141	FBJ osteosarcoma oncogene	Mus musculus	30-35
19595440-8	2009	Capsaicin-induced improvement of the spatial learning was reversed by administration of an anti-IGF-I antibody and by that of a CGRP receptor antagonist CGRP (8-37) in WT mice.	Capsaicin	0-9	insulin-like growth factor 1	Mus musculus	96-101
19595440-8	2009	Capsaicin-induced improvement of the spatial learning was reversed by administration of an anti-IGF-I antibody and by that of a CGRP receptor antagonist CGRP (8-37) in WT mice.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	128-132
19595440-8	2009	Capsaicin-induced improvement of the spatial learning was reversed by administration of an anti-IGF-I antibody and by that of a CGRP receptor antagonist CGRP (8-37) in WT mice.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	153-157
19595440-10	2009	These observations strongly suggest that the stimulation of sensory neurons by capsaicin might increase IGF-I production via increasing the hippocampal tissue CGRP levels, and it may thereby promote angiogenesis and neurogenesis to produce improvement of the cognitive function in mice.	Capsaicin	79-88	insulin-like growth factor 1	Mus musculus	104-109
19595440-10	2009	These observations strongly suggest that the stimulation of sensory neurons by capsaicin might increase IGF-I production via increasing the hippocampal tissue CGRP levels, and it may thereby promote angiogenesis and neurogenesis to produce improvement of the cognitive function in mice.	Capsaicin	79-88	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	159-163
19539789-0	2009	N-arachidonyl dopamine sensitizes rat capsaicin-sensitive lung vagal afferents via activation of TRPV1 receptors.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-102
19512868-1	2009	BACKGROUND: Nociceptive-selective local anesthesia is produced by entry of the permanently charged lidocaine-derivative QX-314 into nociceptors when coadministered with capsaicin, a transient receptor potential vanilloid 1 (TRPV1) channel agonist.	Capsaicin	169-178	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	224-229
19539789-1	2009	We investigated the effect of N-arachidonyl dopamine (NADA), an endogenous agonist of both transient receptor potential vanilloid 1 (TRPV1) and cannabinoid CB1 receptors, on the sensitivity of rat capsaicin-sensitive lung vagal afferent (CSLVA) fibers.	Capsaicin	197-206	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-131
19602228-9	2009	Further studies revealed that TDAG8 activation sensitized the TRPV1 response to capsaicin, suggesting that TDAG8 could be involved in CFA-induced chronic inflammatory pain through regulation of TRPV1 function.	Capsaicin	80-89	G protein-coupled receptor 65	Homo sapiens	30-35
19602228-9	2009	Further studies revealed that TDAG8 activation sensitized the TRPV1 response to capsaicin, suggesting that TDAG8 could be involved in CFA-induced chronic inflammatory pain through regulation of TRPV1 function.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-67
19602228-9	2009	Further studies revealed that TDAG8 activation sensitized the TRPV1 response to capsaicin, suggesting that TDAG8 could be involved in CFA-induced chronic inflammatory pain through regulation of TRPV1 function.	Capsaicin	80-89	G protein-coupled receptor 65	Homo sapiens	107-112
19602228-9	2009	Further studies revealed that TDAG8 activation sensitized the TRPV1 response to capsaicin, suggesting that TDAG8 could be involved in CFA-induced chronic inflammatory pain through regulation of TRPV1 function.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	194-199
19362118-0	2009	Involvement of capsaicin-sensitive afferent nerves in the proteinase-activated receptor 2-mediated vasodilatation in the rat dura mater.	Capsaicin	15-24	F2R like trypsin receptor 1	Rattus norvegicus	58-89
19362118-2	2009	Recent findings demonstrated that the rat dura mater is innervated by trigeminal capsaicin-sensitive peptidergic nociceptive afferent nerves which mediate meningeal vascular responses through activation of the transient receptor potential vanilloid type 1 (TRPV1) receptor.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	210-255
19362118-2	2009	Recent findings demonstrated that the rat dura mater is innervated by trigeminal capsaicin-sensitive peptidergic nociceptive afferent nerves which mediate meningeal vascular responses through activation of the transient receptor potential vanilloid type 1 (TRPV1) receptor.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	257-262
19362118-3	2009	The present work explored the functional significance of the capsaicin-sensitive subpopulation of dural afferent nerves via their contribution to the meningeal vascular responses evoked through activation of the proteinase-activated receptor 2 (PAR-2).	Capsaicin	61-70	F2R like trypsin receptor 1	Rattus norvegicus	212-243
19362118-3	2009	The present work explored the functional significance of the capsaicin-sensitive subpopulation of dural afferent nerves via their contribution to the meningeal vascular responses evoked through activation of the proteinase-activated receptor 2 (PAR-2).	Capsaicin	61-70	F2R like trypsin receptor 1	Rattus norvegicus	245-250
19362118-6	2009	The SLIGRL-NH(2)-induced vasodilatation was significantly reduced following capsaicin-sensitive afferent nerve defunctionalization by prior systemic capsaicin treatment and by pretreatment of the dura mater with the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37).	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	216-247
19362118-6	2009	The SLIGRL-NH(2)-induced vasodilatation was significantly reduced following capsaicin-sensitive afferent nerve defunctionalization by prior systemic capsaicin treatment and by pretreatment of the dura mater with the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37).	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	249-253
19362118-6	2009	The SLIGRL-NH(2)-induced vasodilatation was significantly reduced following capsaicin-sensitive afferent nerve defunctionalization by prior systemic capsaicin treatment and by pretreatment of the dura mater with the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37).	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	275-279
19362118-9	2009	The present findings demonstrate that activation of the PAR-2 localized on capsaicin-sensitive trigeminal nociceptive afferent nerves induces vasodilatation in the dural vascular bed by mechanisms involving NO and CGRP release.	Capsaicin	75-84	F2R like trypsin receptor 1	Rattus norvegicus	56-61
19362118-9	2009	The present findings demonstrate that activation of the PAR-2 localized on capsaicin-sensitive trigeminal nociceptive afferent nerves induces vasodilatation in the dural vascular bed by mechanisms involving NO and CGRP release.	Capsaicin	75-84	calcitonin-related polypeptide alpha	Rattus norvegicus	214-218
19362118-10	2009	The results indicate that the PAR-2-mediated activation and sensitization of meningeal capsaicin-sensitive C-fiber nociceptors may be significantly implicated in the pathophysiology of headaches.	Capsaicin	87-96	F2R like trypsin receptor 1	Rattus norvegicus	30-35
19389802-3	2009	Contraction was similarly abolished by supernatant of mucosal sac filled with the TRPV1 agonist capsaicin (10(-6) M).	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
19491712-7	2009	TRPA1 expressed in capsaicin-sensitive and insensitive neurons.	Capsaicin	19-28	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
19429182-0	2009	Role of ET(A) and ET(B) endothelin receptors on endothelin-1-induced potentiation of nociceptive and thermal hyperalgesic responses evoked by capsaicin in rats.	Capsaicin	142-151	endothelin 1	Rattus norvegicus	48-60
19369364-2	2009	The TRPV1 receptors are expressed on both the peripheral and central branches of these dorsal root ganglion (DRG) neurons and can be activated by capsaicin, heat, low pH, and also by recently described endogenous lipids.	Capsaicin	146-155	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
19686135-4	2009	This is illustrated by the use of capsaicin, menthol, and wasabi to identify the heat-sensitive ion channel TRPV1, the cold-sensitive ion channel TRPM8, and the irritant receptor TRPA1, respectively.	Capsaicin	34-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	108-113
19686135-4	2009	This is illustrated by the use of capsaicin, menthol, and wasabi to identify the heat-sensitive ion channel TRPV1, the cold-sensitive ion channel TRPM8, and the irritant receptor TRPA1, respectively.	Capsaicin	34-43	transient receptor potential cation channel subfamily M member 8	Homo sapiens	146-151
19686135-4	2009	This is illustrated by the use of capsaicin, menthol, and wasabi to identify the heat-sensitive ion channel TRPV1, the cold-sensitive ion channel TRPM8, and the irritant receptor TRPA1, respectively.	Capsaicin	34-43	transient receptor potential cation channel subfamily A member 1	Homo sapiens	179-184
19686222-4	2009	Calcium imaging of isolated dorsal root ganglia neurons grown with nerve growth factor was used to test the in vitro effects of Artn on TRPV1 activation by capsaicin in young and old neurons.	Capsaicin	156-165	artemin	Mus musculus	128-132
19686222-4	2009	Calcium imaging of isolated dorsal root ganglia neurons grown with nerve growth factor was used to test the in vitro effects of Artn on TRPV1 activation by capsaicin in young and old neurons.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	136-141
19686222-5	2009	Artn potentiated initial TRPV1 responses to capsaicin in young and old neurons, but the percent of capsaicin responders following repeated exposure to capsaicin increased only in young neurons.	Capsaicin	44-53	artemin	Mus musculus	0-4
19559390-8	2009	ET-1 also enhanced the capsaicin-stimulated release of CGRP (up to 2-fold for 0.3 nM ET-1), but did not change capsaicin-stimulated glutamate release.	Capsaicin	23-32	endothelin 1	Rattus norvegicus	0-4
19559390-8	2009	ET-1 also enhanced the capsaicin-stimulated release of CGRP (up to 2-fold for 0.3 nM ET-1), but did not change capsaicin-stimulated glutamate release.	Capsaicin	23-32	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
19559390-8	2009	ET-1 also enhanced the capsaicin-stimulated release of CGRP (up to 2-fold for 0.3 nM ET-1), but did not change capsaicin-stimulated glutamate release.	Capsaicin	23-32	endothelin 1	Rattus norvegicus	85-89
19423224-1	2009	Itch evoked by cowhage or histamine is reduced or blocked by capsaicin desensitization, suggesting that pruriceptive neurons are capsaicin-sensitive.	Capsaicin	61-70	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
19561608-4	2009	We show that access to the pore of TRPV1 is gated by S6 in response to both capsaicin binding and increases in temperature, that the pore-forming S6 segments are helical structures and that two constrictions are present in the pore: one that impedes the access of large molecules and the other that hampers the access of smaller ions and constitutes an activation gate of these channels.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-40
19423224-1	2009	Itch evoked by cowhage or histamine is reduced or blocked by capsaicin desensitization, suggesting that pruriceptive neurons are capsaicin-sensitive.	Capsaicin	129-138	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
19423224-2	2009	Topical capsaicin can evoke both nociceptive sensations and itch, whereas intradermal injection of capsaicin evokes only burning pain.	Capsaicin	8-17	itchy E3 ubiquitin protein ligase	Homo sapiens	60-64
19327387-4	2009	We report, that NAPE-PLD is expressed both in dorsal root ganglia and cultures prepared from dorsal root ganglia and grown in the absence of capsaicin.	Capsaicin	141-150	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	16-24
19501497-9	2009	Eugenol and capsaicin inhibited thromboxane B2 (TXB2) formation in platelets in a dose-dependent manner challenged with AA apparently by the inhibition of the cyclooxygenase (COX-1).	Capsaicin	12-21	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	175-180
19327387-5	2009	Furthermore, we also report that capsaicin application downregulates the expression of NAPE-PLD as well as the capsaicin receptor, transient receptor potential vanilloid type 1 ion channel, by about 70% in the cultures prepared from dorsal root ganglia.	Capsaicin	33-42	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	87-95
19327387-6	2009	These findings indicate that a major sub-population of capsaicin-sensitive primary sensory neurons expresses NAPE-PLD, and suggest that NAPE-PLD is expressed predominantly by capsaicin-sensitive neurons in dorsal root ganglia.	Capsaicin	55-64	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	109-117
19327387-6	2009	These findings indicate that a major sub-population of capsaicin-sensitive primary sensory neurons expresses NAPE-PLD, and suggest that NAPE-PLD is expressed predominantly by capsaicin-sensitive neurons in dorsal root ganglia.	Capsaicin	175-184	N-acyl phosphatidylethanolamine phospholipase D	Mus musculus	136-144
19285119-0	2009	Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons.	Capsaicin	67-76	glial cell line derived neurotrophic factor	Mus musculus	0-43
19285119-0	2009	Glial cell line-derived neurotrophic factor family ligands enhance capsaicin-stimulated release of calcitonin gene-related peptide from sensory neurons.	Capsaicin	67-76	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	99-130
19285119-3	2009	Exposure of isolated sensory neurons in culture to GDNF, neurturin, and artemin enhanced the capsaicin-stimulated release of immunoreactive calcitonin gene-related peptide (iCGRP) two- to threefold, but did not increase potassium-stimulated release of iCGRP.	Capsaicin	93-102	glial cell line derived neurotrophic factor	Mus musculus	51-55
19285119-3	2009	Exposure of isolated sensory neurons in culture to GDNF, neurturin, and artemin enhanced the capsaicin-stimulated release of immunoreactive calcitonin gene-related peptide (iCGRP) two- to threefold, but did not increase potassium-stimulated release of iCGRP.	Capsaicin	93-102	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	140-171
19531269-7	2009	TRPV1 was stimulated with capsaicin or its potent analog, resiniferatoxin.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
19531269-12	2009	The PBN blocks increases in TNFR1 and ROS production induced by capsaicin/resiniferatoxin.	Capsaicin	64-73	tumor necrosis factor receptor superfamily, member 1a	Mus musculus	28-33
19294370-2	2009	TRPV1 receptors can be activated by noxious heat, acid, capsaicin and resiniferatoxin, leading to burning pain or itch mediated by discharges in C polymodal and Adelta mechano-heat nociceptors and in central neurons, including spinothalamic tract (STT) cells.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
19457767-8	2009	Either NGF (10 ng/ml) or butyrate (1 mmol/L) promoted expression of SP mRNA, VR1 mRNA, and VR1 protein in DRG neurons and capsaicin-evoked SP release from DRG neurons.	Capsaicin	122-131	nerve growth factor	Rattus norvegicus	7-10
19457767-9	2009	Co-administration of NGF and butyrate showed a synergistic effect on expression of VR1 mRNA, and VR1 protein in DRG neurons and capsaicin-evoked SP release from DRG neurons and a ceiling effect on SP mRNA expression.	Capsaicin	128-137	nerve growth factor	Rattus norvegicus	21-24
19457767-10	2009	The elevation of SP mRNA, VR1 mRNA, and VR1 protein promoted by NGF and/or butyrate may be associated with increases of SP release evoked by capsaicin.	Capsaicin	141-150	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	40-43
19457767-10	2009	The elevation of SP mRNA, VR1 mRNA, and VR1 protein promoted by NGF and/or butyrate may be associated with increases of SP release evoked by capsaicin.	Capsaicin	141-150	nerve growth factor	Rattus norvegicus	64-67
19502719-6	2009	Serum levels of IGF-I significantly increased in both normotensive and hypertensive volunteers after administration of capsaicin and isoflavone.	Capsaicin	119-128	insulin like growth factor 1	Homo sapiens	16-21
19502719-7	2009	These observations suggest that administration of capsaicin and isoflavone might reduce BP in hypertensive, but not in normotensive subjects, probably by increasing serum levels of IGF-I.	Capsaicin	50-59	insulin like growth factor 1	Homo sapiens	181-186
19238310-14	2009	CONCLUSIONS: An acute lunch containing capsaicin had no effect on satiety, EE, and PYY, but increased GLP-1 and tended to decrease ghrelin.	Capsaicin	39-48	glucagon	Homo sapiens	102-107
19139871-12	2009	Capsaicin has a long-lasting desensitizing action, brain-derived neurotrophic factor, and tumor necrosis factor-alpha, a short-lasting one.	Capsaicin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	51-117
19059884-3	2009	Recent studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1), an ion channel largely restricted to a subset of capsaicin-sensitive sensory nerves, functions as a transducer capable of initiating reflex responses to many reactive chemical stimuli.	Capsaicin	135-144	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	38-76
19059884-3	2009	Recent studies have demonstrated that transient receptor potential ankyrin 1 (TRPA1), an ion channel largely restricted to a subset of capsaicin-sensitive sensory nerves, functions as a transducer capable of initiating reflex responses to many reactive chemical stimuli.	Capsaicin	135-144	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	78-83
18852258-6	2009	Phosphorylation of ERK in the spinal dorsal horn was detected following intracolonic NaHS or capsaicin.	Capsaicin	93-102	mitogen-activated protein kinase 1	Mus musculus	19-22
19201768-7	2009	RESULTS: Either NaHS or capsaicin induced the expression of Fos protein in the superficial layers of the T8 and T9 spinal dorsal horn of rats or mice.	Capsaicin	24-33	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-63
19206161-1	2009	Transient receptor potential vanilloid type 1 (TRPV1) is a molecular sensor for detecting adverse stimuli, such as capsaicin, heat, and acid.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-45
19404626-7	2009	Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	118-123
19404626-7	2009	Ruthenium red, a water soluble polycationic dye, was found to block the pore of the capsaicin-operated cation channel TRPV1 thus interfering with all polymodal ways of TRPV1 activation.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	168-173
19206161-1	2009	Transient receptor potential vanilloid type 1 (TRPV1) is a molecular sensor for detecting adverse stimuli, such as capsaicin, heat, and acid.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
19206161-6	2009	The UV-induced MMP-1 expression in HaCaT was also decreased by TRPV1 inhibitors and was facilitated by capsaicin.	Capsaicin	103-112	matrix metallopeptidase 1	Homo sapiens	15-20
19398380-4	2009	In the rats with PEN or PRO administration, a large number of pERK-like immunoreactive (LI) cells was observed in the trigeminal spinal subnuclei interpolaris and caudalis transition zone (Vi/Vc), middle Vc, and transition zone between Vc and upper cervical spinal cord (Vc/C2) following capsaicin injection into the whisker-pad region.	Capsaicin	288-297	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	62-66
19428784-0	2009	Capsaicin promotes the amyloidogenic route of brain amyloid precursor protein processing.	Capsaicin	0-9	amyloid beta precursor protein	Rattus norvegicus	52-77
19428784-3	2009	In this study, the effects of capsaicin on the processing of amyloid precursor protein (APP) were investigated in an in vivo model.	Capsaicin	30-39	amyloid beta precursor protein	Rattus norvegicus	61-86
19439586-7	2009	Furthermore, focal application of the TRPV1 agonists capsaicin and anandamide evoked a transduction-like current.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	38-43
19439586-8	2009	The capsaicin-evoked and endogenous transduction current displayed prominent outward rectification, a property of the TRPV1 channel.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	118-123
19298793-6	2009	The EC(50) values of these compounds for TRPV1 were around 100 microM against that of capsaicin (CAP), 25.6 nM and maximum responses of garlic compounds were half to that of CAP.	Capsaicin	86-95	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	41-46
19279663-7	2009	Expression of TRAAK alone or in association with TREK-1 controls heat responses of both capsaicin-sensitive and capsaicin-insensitive sensory neurons.	Capsaicin	88-97	potassium channel, subfamily K, member 4	Mus musculus	14-19
19279663-7	2009	Expression of TRAAK alone or in association with TREK-1 controls heat responses of both capsaicin-sensitive and capsaicin-insensitive sensory neurons.	Capsaicin	88-97	potassium channel, subfamily K, member 2	Mus musculus	49-55
19279663-7	2009	Expression of TRAAK alone or in association with TREK-1 controls heat responses of both capsaicin-sensitive and capsaicin-insensitive sensory neurons.	Capsaicin	112-121	potassium channel, subfamily K, member 4	Mus musculus	14-19
19279663-7	2009	Expression of TRAAK alone or in association with TREK-1 controls heat responses of both capsaicin-sensitive and capsaicin-insensitive sensory neurons.	Capsaicin	112-121	potassium channel, subfamily K, member 2	Mus musculus	49-55
19502719-0	2009	Effects of capsaicin and isoflavone on blood pressure and serum levels of insulin-like growth factor-I in normotensive and hypertensive volunteers with alopecia.	Capsaicin	11-20	insulin like growth factor 1	Homo sapiens	74-102
19502719-2	2009	Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension.	Capsaicin	24-33	insulin like growth factor 1	Homo sapiens	75-80
19502719-2	2009	Since administration of capsaicin and isoflavone increases serum levels of IGF-I by sensory neuron stimulation in subjects with alopecia, it is possible that administration of capsaicin and isoflavone reduces arterial blood pressure in patients with hypertension.	Capsaicin	176-185	insulin like growth factor 1	Homo sapiens	75-80
19397909-3	2009	Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-30
19397909-3	2009	Moreover, the prototypic TRPV1 agonist capsaicin specifically (i.e. via TRPV1) and dose-dependently inhibited cytokine-induced DC differentiation, phagocytosis of bacteria, activation of DCs, and pro-inflammatory cytokine secretion.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
19361196-2	2009	Binding of 4alpha-phorbol esters occurs in a loop in the TM3-TM4 domain of TRPV4 that is analogous to the capsaicin binding site of TRPV1, and the ester decoration of ring C and the A,B ring junction are critical for activity.	Capsaicin	106-115	transient receptor potential cation channel subfamily V member 4	Homo sapiens	75-80
19361196-2	2009	Binding of 4alpha-phorbol esters occurs in a loop in the TM3-TM4 domain of TRPV4 that is analogous to the capsaicin binding site of TRPV1, and the ester decoration of ring C and the A,B ring junction are critical for activity.	Capsaicin	106-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	132-137
19420725-3	2009	We discovered the following: Capsaicin, a TRPV1 agonist, enhanced thermogenesis and heat diffusion; thymol and ethyl vanillin, TRPV3 agonists, did not have any effect on thermogenesis or heat diffusion; menthol and 1,8-cineole, TRPM8 agonists, enhanced thermogenesis; and allyl isothiocyanate and cinnamaldehyde, TRPA1 agonists, enhanced thermogenesis and inhibited heat diffusion.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
19220220-3	2009	METHODS: Nasal challenges were carried out with the TRPV1-activators capsaicin, anandamide and olvanil.	Capsaicin	69-78	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
19286963-1	2009	In rats, hindlimb muscle ischemia induced by femoral artery occlusion augments the sympathetic nervous response to stimulation of transient receptor potential vanilloid type 1 (TRPV1) by injection of capsaicin into the arterial blood supply of the hindlimb muscles.	Capsaicin	200-209	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	130-175
19286963-1	2009	In rats, hindlimb muscle ischemia induced by femoral artery occlusion augments the sympathetic nervous response to stimulation of transient receptor potential vanilloid type 1 (TRPV1) by injection of capsaicin into the arterial blood supply of the hindlimb muscles.	Capsaicin	200-209	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	177-182
19286963-6	2009	Furthermore, when NGF was infused in the hindlimb muscles of healthy rats (72 h using an osmotic minipump), the magnitude of the DRG neuron response to capsaicin was augmented (5.4 +/- 0.54 nA with NGF infusion vs. 3.0 +/- 0.17 nA in control; P < 0.05).	Capsaicin	152-161	nerve growth factor	Rattus norvegicus	18-21
19286963-6	2009	Furthermore, when NGF was infused in the hindlimb muscles of healthy rats (72 h using an osmotic minipump), the magnitude of the DRG neuron response to capsaicin was augmented (5.4 +/- 0.54 nA with NGF infusion vs. 3.0 +/- 0.17 nA in control; P < 0.05).	Capsaicin	152-161	nerve growth factor	Rattus norvegicus	198-201
19286963-7	2009	With the addition of NGF in the culture dish containing the DRG neurons, the magnitude of the DRG neuron response to capsaicin was greater (6.4 +/- 0.27 nA; P < 0.05 vs. control) than that seen in control (2.9 +/- 0.16 nA).	Capsaicin	117-126	nerve growth factor	Rattus norvegicus	21-24
19285962-0	2009	Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress.	Capsaicin	0-9	interleukin 6	Homo sapiens	23-27
19285962-0	2009	Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress.	Capsaicin	0-9	signal transducer and activator of transcription 3	Homo sapiens	28-33
19285962-0	2009	Capsaicin inhibits the IL-6/STAT3 pathway by depleting intracellular gp130 pools through endoplasmic reticulum stress.	Capsaicin	0-9	interleukin 6 cytokine family signal transducer	Homo sapiens	69-74
19285962-2	2009	It was recently reported that capsaicin inhibited interleukin-6 (IL-6)-induced activation of signal transducer and activator of transcription 3 (STAT3), an anti-apoptotic transcription factor.	Capsaicin	30-39	interleukin 6	Homo sapiens	50-63
19161409-1	2009	Transient receptor potential vanilloid type 1 (TRPV1) is activated by various stimuli including capsaicin, heat and acid.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-45
19285962-2	2009	It was recently reported that capsaicin inhibited interleukin-6 (IL-6)-induced activation of signal transducer and activator of transcription 3 (STAT3), an anti-apoptotic transcription factor.	Capsaicin	30-39	interleukin 6	Homo sapiens	65-69
19285962-2	2009	It was recently reported that capsaicin inhibited interleukin-6 (IL-6)-induced activation of signal transducer and activator of transcription 3 (STAT3), an anti-apoptotic transcription factor.	Capsaicin	30-39	signal transducer and activator of transcription 3	Homo sapiens	93-143
19285962-2	2009	It was recently reported that capsaicin inhibited interleukin-6 (IL-6)-induced activation of signal transducer and activator of transcription 3 (STAT3), an anti-apoptotic transcription factor.	Capsaicin	30-39	signal transducer and activator of transcription 3	Homo sapiens	145-150
19285962-3	2009	Here we demonstrate that capsaicin induced downregulation of the IL-6 receptor gp130 within 2h in glial tumors.	Capsaicin	25-34	interleukin 6	Homo sapiens	65-69
19285962-3	2009	Here we demonstrate that capsaicin induced downregulation of the IL-6 receptor gp130 within 2h in glial tumors.	Capsaicin	25-34	interleukin 6 cytokine family signal transducer	Homo sapiens	79-84
19285962-6	2009	The depletion of the intracellular pool of gp130 by capsaicin and an ER stress inducer led to an immediate loss of the IL-6 response due to the short half-life of membrane localized gp130.	Capsaicin	52-61	interleukin 6 cytokine family signal transducer	Homo sapiens	43-48
19285962-6	2009	The depletion of the intracellular pool of gp130 by capsaicin and an ER stress inducer led to an immediate loss of the IL-6 response due to the short half-life of membrane localized gp130.	Capsaicin	52-61	interleukin 6	Homo sapiens	119-123
19285962-6	2009	The depletion of the intracellular pool of gp130 by capsaicin and an ER stress inducer led to an immediate loss of the IL-6 response due to the short half-life of membrane localized gp130.	Capsaicin	52-61	interleukin 6 cytokine family signal transducer	Homo sapiens	182-187
19236908-7	2009	Capsazepine (10 microM), a TRPV1 receptor antagonist, abolished the effect of capsaicin on mEPSCs.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
19411839-7	2009	However, the TRPV1 agonist capsaicin, which activated TRPV1 currents in HEK cells expressing TRPV1, was unable to evoke current in these freshly isolated guinea-pig urothelial cells.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	13-18
19411839-7	2009	However, the TRPV1 agonist capsaicin, which activated TRPV1 currents in HEK cells expressing TRPV1, was unable to evoke current in these freshly isolated guinea-pig urothelial cells.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	54-59
19411839-7	2009	However, the TRPV1 agonist capsaicin, which activated TRPV1 currents in HEK cells expressing TRPV1, was unable to evoke current in these freshly isolated guinea-pig urothelial cells.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	54-59
19161409-1	2009	Transient receptor potential vanilloid type 1 (TRPV1) is activated by various stimuli including capsaicin, heat and acid.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
19223122-6	2009	At a negative holding potential, the P2X(3) receptor agonist alpha,beta-meATP induced less current in the presence of the TRPV1 agonist capsaicin than that in its absence.	Capsaicin	136-145	purinergic receptor P2X 3	Homo sapiens	37-43
18280595-2	2009	The potent vasodilator calcitonin gene-related peptide (CGRP) is stored in a population of C-fiber afferents that are sensitive to capsaicin.	Capsaicin	131-140	Calcitonin gene-related peptide	Sus scrofa	56-60
18280595-5	2009	Furthermore, it has also been reported that capsaicin-treated pigs significantly increase mean arterial blood pressure compared with controls and that the decrease in CGRP synthesis and release contributes to the elevated blood pressure.	Capsaicin	44-53	Calcitonin gene-related peptide	Sus scrofa	167-171
19223122-6	2009	At a negative holding potential, the P2X(3) receptor agonist alpha,beta-meATP induced less current in the presence of the TRPV1 agonist capsaicin than that in its absence.	Capsaicin	136-145	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
19150372-2	2009	TRPV1 is considered as a highly validated pain target because, i) its agonists such as capsaicin cause desensitization of TRPV1 channels that relieves pain behaviors in preclinical species, and ii) its antagonists relieve pain behaviors in rodent models of inflammation, osteoarthritis, and cancer.	Capsaicin	87-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
19121396-3	2009	The functional activity of the expressed TRPV1 was confirmed by whole-cell ligand-gated ion flux recordings in the presence of capsaicin and low pH and via specific ligand binding to the isolated cellular membranes.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
19176891-1	2009	The satiating potency of CCK has been well characterized, including its mediation by capsaicin-sensitive vagal primary afferents.	Capsaicin	85-94	cholecystokinin	Rattus norvegicus	25-28
19158342-6	2009	The TRPV1 agonist capsaicin (1-100 microM) and the TRPA1/TRPM8 agonist menthol (5-200 microM) elicited transient currents in a moderate percentage of cells ( approximately 25%).	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
19150372-2	2009	TRPV1 is considered as a highly validated pain target because, i) its agonists such as capsaicin cause desensitization of TRPV1 channels that relieves pain behaviors in preclinical species, and ii) its antagonists relieve pain behaviors in rodent models of inflammation, osteoarthritis, and cancer.	Capsaicin	87-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
19139269-11	2009	DHC induced rapid and high-sustained c-Jun NH(2)-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK) activation, but capsaicin induced transient activation of JNK/ERK.	Capsaicin	131-140	mitogen-activated protein kinase 8	Homo sapiens	173-176
19419422-4	2009	A capsaicin-sensitive subset of rat and mouse trigeminal ganglion sensory neurons was activated with TRPA1-specific agonists, mustard oil and the cannabinoid WIN55,212.	Capsaicin	2-11	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	101-106
19139269-2	2009	Capsaicin (8-methyl-N-vanillyl-6-nonenamide) and its analog, dihydrocapsaicin (DHC), induced caspase-3-independent/-dependent signaling pathways in WI38 lung epithelial fibroblast cells.	Capsaicin	0-9	caspase 3	Homo sapiens	93-102
19139269-11	2009	DHC induced rapid and high-sustained c-Jun NH(2)-terminal kinase (JNK)/extracellular signal-regulated kinase (ERK) activation, but capsaicin induced transient activation of JNK/ERK.	Capsaicin	131-140	mitogen-activated protein kinase 1	Homo sapiens	177-180
19139269-2	2009	Capsaicin (8-methyl-N-vanillyl-6-nonenamide) and its analog, dihydrocapsaicin (DHC), induced caspase-3-independent/-dependent signaling pathways in WI38 lung epithelial fibroblast cells.	Capsaicin	11-43	caspase 3	Homo sapiens	93-102
19139269-4	2009	Exposure to capsaicin or DHC caused induction of p53, p21, and G(0)/G(1) arrest.	Capsaicin	12-21	tumor protein p53	Homo sapiens	49-52
19139269-4	2009	Exposure to capsaicin or DHC caused induction of p53, p21, and G(0)/G(1) arrest.	Capsaicin	12-21	H3 histone pseudogene 16	Homo sapiens	54-57
19139269-14	2009	Capsaicin and DHC induced Akt phosphorylation, and the phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], induced autophagy via ERK activation.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	26-29
19139269-14	2009	Capsaicin and DHC induced Akt phosphorylation, and the phosphatidylinositol 3-kinase inhibitors, wortmannin and LY294002 [2-(4-morpholinyl)-8-phenyl-1(4H)-benzopyran-4-one hydrochloride], induced autophagy via ERK activation.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	210-213
19139269-15	2009	Our results indicate that the differential responses of capsaicin and DHC for cell protection are caused by the extent of the UPR and autophagy that are both regulated by the level of JNK and ERK activation.	Capsaicin	56-65	mitogen-activated protein kinase 8	Homo sapiens	184-187
19139269-15	2009	Our results indicate that the differential responses of capsaicin and DHC for cell protection are caused by the extent of the UPR and autophagy that are both regulated by the level of JNK and ERK activation.	Capsaicin	56-65	mitogen-activated protein kinase 1	Homo sapiens	192-195
19267374-0	2009	Synthesis and vanilloid receptor (TRPV1) activity of the enantiomers of alpha-fluorinated capsaicin.	Capsaicin	90-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
19171673-7	2009	9-OA-NO(2) activated a subset of mouse vagal and trigeminal sensory neurons, which also responded to the TRPA1 agonist allyl isothiocyanate and the TRPV1 agonist capsaicin.	Capsaicin	162-171	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	148-153
19171673-10	2009	9-OA-NO(2) evoked robust action potential discharge from capsaicin-sensitive fibers with slow conduction velocities (0.4-0.7 m/s), which was inhibited by the TRPA1 antagonist AP-18.	Capsaicin	57-66	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	158-163
19172228-0	2009	Melatonin treatment decreases c-fos expression in a headache model induced by capsaicin.	Capsaicin	78-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-35
19172228-4	2009	On the other hand, pinealectomized rats, which received capsaicin, presented the highest number of c-fos-positive cells.	Capsaicin	56-65	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-104
19368813-3	2009	Capsaicin releases substance P from axon collaterals in the periphery initiating vasodilatation and plasma extravasation.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	19-30
19368813-11	2009	The correlation between reduced capsaicin-evoked pain and increased skin temperature suggests an increased substance P release while the delayed onset and diminished magnitude of capsaicin-induced pain may be due to reduced penetration of capsaicin into the epidermis.	Capsaicin	32-41	tachykinin precursor 1	Homo sapiens	107-118
19101577-1	2009	Endogenous analogues of capsaicin, N-acyldopamines, were previously identified from striatal extracts, but the putative presynaptic role of their receptor, the TRPV(1)R (formerly: vanilloid or capsaicin receptor) in the caudate-putamen is unclear.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	193-211
18668366-1	2009	BACKGROUND: Capsaicin is known to have regulatory effects on gastrointestinal functions via the vanilloid receptor (VR1).	Capsaicin	12-21	vault RNA 1-1	Homo sapiens	116-119
18668366-3	2009	AIM: To identify VR1-expressing endocrine-like cells in human antral glands and to examine whether stimulation with capsaicin causes release of gastrin, somatostatin, and serotonin.	Capsaicin	116-125	gastrin	Homo sapiens	144-151
18668366-12	2009	Capsaicin-stimulation caused a consistent raise of the gastrin concentrations in the gland preparations from all subjects.	Capsaicin	0-9	gastrin	Homo sapiens	55-62
18668366-14	2009	CONCLUSION: This study shows that capsaicin stimulates gastrin secretion from isolated human antral glands, and that a chilli-rich diet decreases this secretion.	Capsaicin	34-43	gastrin	Homo sapiens	55-62
19348729-2	2009	The direct membrane effects of a TRPV1 receptor agonist, capsaicin, were examined by gramicidin-perforated patch clamp recording using a trigeminal brainstem slice preparation containing Vc from immature mice.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	33-38
19348729-5	2009	In addition, capsaicin-induced depolarization was maintained in the presence of L-732,138 (1 microM), an NK1 receptor antagonist, in 14 out of 17 neurons (82%) tested.	Capsaicin	13-22	tachykinin receptor 1	Mus musculus	105-117
19348729-6	2009	The capsaicin-induced depolarizing effects were blocked by a TRPV1 receptor antagonist, capsazepine (10 microM).	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	61-66
19348729-7	2009	These results indicate that a sub-population of SG neurons in the Vc express functional TRPV1 receptors, and that capsaicin can directly activate the TRPV1 receptor on the postsynaptic membrane of SG neurons.	Capsaicin	114-123	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	150-155
18774343-9	2009	In addition, sustained morphine increased flinching and plasma extravasation after peripheral stimulation with capsaicin, suggesting an increase in TRPV1 receptor function in the periphery in morphine-treated animals.	Capsaicin	111-120	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	148-153
19174160-3	2009	Heat and capsaicin activate TRPV1 but not TRPV4 in yeast.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	28-33
19135797-1	2009	Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands.	Capsaicin	163-172	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-45
19135797-1	2009	Transient receptor potential vanilloid type 1 (TRPV1) is a ligand-gated ion channel that functions as an integrator of multiple pain stimuli including heat, acid, capsaicin and a variety of putative endogenous lipid ligands.	Capsaicin	163-172	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
19159661-8	2009	These results demonstrate that xylene-induced acute nocifensive behaviour is mediated by capsaicin-sensitive afferents via TRPV1 receptor activation in mice.	Capsaicin	89-98	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	123-128
19705551-7	2009	These two ethanol behaviors were changed in the opposite direction after injection of capsaicin, a selective TRPV1 agonist, in wild type mice.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	109-114
19243225-3	2009	Here we address the problem at the receptor level and show that the capsaicin ion channel TRPV1, which mediates nociception at the peripheral nerve terminals, possesses properties essential to the adaptation of sensory responses.	Capsaicin	68-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	90-95
19208258-11	2009	The expression of TRP channels has been shown in other areas of the CNS; application of 4alpha-PDD significantly increased the mEPSC frequency in cultured hippocampal neurons, which was further potentiated by PDBu, whereas, TRPV1 agonist capsaicin did not modulate synaptic transmission.	Capsaicin	238-247	transient receptor potential cation channel subfamily V member 1	Homo sapiens	224-229
19116139-0	2009	Capsaicin binds to prohibitin 2 and displaces it from the mitochondria to the nucleus.	Capsaicin	0-9	prohibitin 2	Homo sapiens	19-31
19116139-4	2009	We show that capsaicin binds to prohibitin (PHB) 2, which is normally localized to the inner mitochondrial membrane, and induces its translocation to the nucleus.	Capsaicin	13-22	prohibitin 1	Homo sapiens	32-42
19116139-4	2009	We show that capsaicin binds to prohibitin (PHB) 2, which is normally localized to the inner mitochondrial membrane, and induces its translocation to the nucleus.	Capsaicin	13-22	prohibitin 2	Homo sapiens	44-50
19103258-9	2009	The present findings suggest that phosphorylation of ERK in NTS neurons may be involved in capsaicin-induced inhibition of swallowing reflex.	Capsaicin	91-100	Eph receptor B1	Rattus norvegicus	53-56
19116139-6	2009	We also provide evidence suggesting that capsaicin causes apoptosis directly through the mitochondria and that PHB2 contributes to capsaicin-induced apoptosis at multiple levels.	Capsaicin	131-140	prohibitin 2	Homo sapiens	111-115
18769453-4	2009	Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
19012739-6	2009	TG neurons cultured upon or treated with FN experienced a leftward shift in the EC(50) of capsaicin-stimulated neuropeptide release.	Capsaicin	90-99	fibronectin 1	Homo sapiens	41-43
19012739-8	2009	Furthermore, TG neurons cultured on FN demonstrated an increase in capsaicin-mediated Ca(2+) accumulation relative to neurons cultured on poly-D-lysine.	Capsaicin	67-76	fibronectin 1	Homo sapiens	36-38
18752301-1	2009	A recent study by our group demonstrates pharmacologically that the transient receptor potential vanilloid-1 (TRPV(1)) is activated by intradermal injection of capsaicin to initiate neurogenic inflammation by the release of neuropeptides in the periphery.	Capsaicin	160-169	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-108
18752301-1	2009	A recent study by our group demonstrates pharmacologically that the transient receptor potential vanilloid-1 (TRPV(1)) is activated by intradermal injection of capsaicin to initiate neurogenic inflammation by the release of neuropeptides in the periphery.	Capsaicin	160-169	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	110-117
18752301-2	2009	In this study, expression of TRPV(1), phosphorylated protein kinase C (p-PKC), and calcitonin gene-related peptide (CGRP) in dorsal root ganglion (DRG) neurons was visualized by using immunofluorescence, real-time PCR, and Western blots to examine whether increases in TRPV(1) mRNA and protein levels evoked by capsaicin injection are subject to modulation by the activation of PKC and to analyze the role of this process in the pathogenesis of neurogenic inflammation.	Capsaicin	311-320	calcitonin-related polypeptide alpha	Rattus norvegicus	116-120
18752301-3	2009	Capsaicin injection into the hindpaw skin of anesthetized rats evoked increases in the expression of TRPV(1), CGRP and p-PKC in mRNA and/or protein levels and in the number of single labeled TRPV(1), p-PKC, and CGRP neurons in ipsilateral L4-5 DRGs.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-108
18752301-3	2009	Capsaicin injection into the hindpaw skin of anesthetized rats evoked increases in the expression of TRPV(1), CGRP and p-PKC in mRNA and/or protein levels and in the number of single labeled TRPV(1), p-PKC, and CGRP neurons in ipsilateral L4-5 DRGs.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	110-114
18752301-3	2009	Capsaicin injection into the hindpaw skin of anesthetized rats evoked increases in the expression of TRPV(1), CGRP and p-PKC in mRNA and/or protein levels and in the number of single labeled TRPV(1), p-PKC, and CGRP neurons in ipsilateral L4-5 DRGs.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	191-198
18752301-3	2009	Capsaicin injection into the hindpaw skin of anesthetized rats evoked increases in the expression of TRPV(1), CGRP and p-PKC in mRNA and/or protein levels and in the number of single labeled TRPV(1), p-PKC, and CGRP neurons in ipsilateral L4-5 DRGs.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	211-215
18752301-6	2009	Taken together, these results provide evidence that up-regulation of TRPV(1) mRNA and protein levels under inflammatory conditions evoked by capsaicin injection is subject to modulation by the PKC cascade in which increased CGRP level in DRG neurons may be related to the initiation of neurogenic inflammation.	Capsaicin	141-150	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-76
18752301-6	2009	Taken together, these results provide evidence that up-regulation of TRPV(1) mRNA and protein levels under inflammatory conditions evoked by capsaicin injection is subject to modulation by the PKC cascade in which increased CGRP level in DRG neurons may be related to the initiation of neurogenic inflammation.	Capsaicin	141-150	calcitonin-related polypeptide alpha	Rattus norvegicus	224-228
19036069-7	2009	The TRPV1 agonist, capsaicin, evoked both Ca(2+) influx and Ca(2+) release from intracellular stores, responses that were blocked in a dose-dependent manner by the TRPV1 antagonists, 5"-Iodo-resiniferatoxin (5"-Iodo-RTX) and AMG 9810.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
19036069-7	2009	The TRPV1 agonist, capsaicin, evoked both Ca(2+) influx and Ca(2+) release from intracellular stores, responses that were blocked in a dose-dependent manner by the TRPV1 antagonists, 5"-Iodo-resiniferatoxin (5"-Iodo-RTX) and AMG 9810.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	164-169
18769453-4	2009	Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
18769453-4	2009	Demonstrating that human skin SG in situ and SZ95 sebocytes in vitro express TRPV1, we show that the prototypic TRPV1 agonist, capsaicin, selectively inhibits basal and arachidonic acid-induced lipid synthesis in a dose-, time-, and extracellular calcium-dependent and a TRPV1-specific manner.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
18769453-5	2009	Low-dose capsaicin stimulates cellular proliferation via TRPV1, whereas higher concentrations inhibit sebocyte growth and induce cell death independent of TRPV1.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	57-62
18839149-5	2009	Intravenous administration of the TRPV1 antagonist, capsazepine (3 mg/kg), significantly reduced the excitatory reflex response to capsaicin.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	34-39
18987162-7	2009	MS reversibly inhibited hTRPV1 activation by polymodal stimuli such as capsaicin, protons, heat, anandamide, and 2-aminoethoxydiphenyl borate.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-30
18987162-8	2009	Because both the stimulatory and inhibitory actions of MS were exhibited in capsaicin- and allicin-insensitive mutant channels, MS-induced hTRPV1 activation was mediated by distinct channel regions from capsaicin and allicin.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	139-145
18987162-8	2009	Because both the stimulatory and inhibitory actions of MS were exhibited in capsaicin- and allicin-insensitive mutant channels, MS-induced hTRPV1 activation was mediated by distinct channel regions from capsaicin and allicin.	Capsaicin	203-212	transient receptor potential cation channel subfamily V member 1	Homo sapiens	139-145
19077146-5	2009	Simultaneous application of galantide (100 nmol L(-1)) and L-NAME (200 micromol L(-1)) significantly reduced the inhibitory effect of capsaicin (30 mumol L(-1)) on vagally induced contractions when compared with its effect in the presence of L-NAME alone or in combination with the selective galanin receptor 2 or 3 antagonists.	Capsaicin	134-143	galanin receptor 2	Mus musculus	292-310
19202316-6	2009	These effects of capsaicin were inhibited by pretreatment with capsazepine, a transient receptor potential vanilloid receptor 1 (TRPV1) competitive antagonist.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-127
19202316-6	2009	These effects of capsaicin were inhibited by pretreatment with capsazepine, a transient receptor potential vanilloid receptor 1 (TRPV1) competitive antagonist.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	129-134
19317053-7	2009	Pimecrolimus cream 1% may act on the transient potential vanilloid 1 (TRPV1) receptor in the skin sensory afferents to induce capsaicin-like response or camphor-like response and then desensitizes TRPV1 and rapidly inhibits or alleviate itching.	Capsaicin	126-135	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
19049892-2	2009	It has been reported that ethanol sensitizes the transient receptor potential vanilloid-1 (TRPV1) to various stimuli and inhalation of ethanol enhances the cough mediated by TRPV1 activation (capsaicin) in patients suffering of airway sensory hyperreactivity.	Capsaicin	192-201	transient receptor potential cation channel subfamily V member 1	Homo sapiens	174-179
19129393-4	2009	Ammonia and intracellular alkalization activate TRPV1 through a mechanism that involves a cytoplasmic histidine residue, not used by other TRPV1 agonists such as heat, capsaicin or low pH.	Capsaicin	168-177	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
18992775-1	2009	Substance P (SP) originally found as a neuropeptide in capsaicin-sensitive sensory neurons, had more recently been identified in non-neuronal cells, especially under pathological conditions.	Capsaicin	55-64	tachykinin 1	Mus musculus	0-11
18992775-1	2009	Substance P (SP) originally found as a neuropeptide in capsaicin-sensitive sensory neurons, had more recently been identified in non-neuronal cells, especially under pathological conditions.	Capsaicin	55-64	tachykinin 1	Mus musculus	13-15
18992775-5	2009	The efficiency of this two-step extraction in differentiating SP in capsaicin-sensitive neurons was verified by using capsaicin as a tool to deplete SP in sensory neurons.	Capsaicin	68-77	tachykinin 1	Mus musculus	62-64
18992775-5	2009	The efficiency of this two-step extraction in differentiating SP in capsaicin-sensitive neurons was verified by using capsaicin as a tool to deplete SP in sensory neurons.	Capsaicin	118-127	tachykinin 1	Mus musculus	149-151
18992775-9	2009	Following capsaicin treatment, both in-vivo and in-vitro, SP recovered in first extraction decreased significantly in lung and skin.	Capsaicin	10-19	tachykinin 1	Mus musculus	58-60
18992775-10	2009	Lastly, presence of capsaicin solvent (10% methanol and 10% Tween 80) or protease inhibitor cocktail in solution altered SP EIA test, yielding false positive results.	Capsaicin	20-29	tachykinin 1	Mus musculus	121-123
18992775-11	2009	These results demonstrated that SP in capsaicin sensitive sensory neurons was extracted in initial extraction of 15 min while non-neuronal SP was present in second extraction.	Capsaicin	38-47	tachykinin 1	Mus musculus	32-34
18977249-3	2009	application of kinin B(1) and B(2) receptor antagonists caused a significant inhibition of the capsaicin-induced cutaneous neurogenic inflammatory response.	Capsaicin	95-104	bradykinin receptor, beta 1	Mus musculus	15-43
19129394-6	2009	Our studies also support the notion that SOD-2 nitration is a critical mechanism that maintains elevated superoxide levels in the spinal cord after capsaicin treatment.	Capsaicin	148-157	superoxide dismutase 2, mitochondrial	Mus musculus	41-46
19059400-0	2009	Capsaicin, a component of red peppers, induces expression of androgen receptor via PI3K and MAPK pathways in prostate LNCaP cells.	Capsaicin	0-9	androgen receptor	Homo sapiens	61-78
19381455-9	2009	A possible mechanism of capsaicin-induced apoptosis is the activation of caspase 3, a major apoptosis-executing enzyme.	Capsaicin	24-33	caspase 3	Homo sapiens	73-82
19059400-1	2009	In this study, capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) induced an increase in the cell viability of the androgen-responsive prostate cancer LNCaP cells, which was reversed by the use of the TRPV1 antagonists capsazepine, I-RTX and SB 366791.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	201-206
19059400-1	2009	In this study, capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide) induced an increase in the cell viability of the androgen-responsive prostate cancer LNCaP cells, which was reversed by the use of the TRPV1 antagonists capsazepine, I-RTX and SB 366791.	Capsaicin	26-64	transient receptor potential cation channel subfamily V member 1	Homo sapiens	201-206
19059400-2	2009	In further studies we observed that capsaicin induced a decrease in ceramide levels as well as Akt and Erk activation.	Capsaicin	36-45	AKT serine/threonine kinase 1	Homo sapiens	95-98
19059400-2	2009	In further studies we observed that capsaicin induced a decrease in ceramide levels as well as Akt and Erk activation.	Capsaicin	36-45	mitogen-activated protein kinase 1	Homo sapiens	103-106
19059400-4	2009	Capsaicin induced an increase in the AR expression that was reverted by the three TRPV1 antagonists.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
19331147-6	2009	The protein levels of Bcl-2 decreased and Bax increased in the mitochondrial fraction while the Bax protein decreased, and p53 and cytochrome c protein levels increased in the cytosolic fraction in HepG2 cells after capsaicin treatment for 24 h by Western blot.	Capsaicin	216-225	BCL2 apoptosis regulator	Homo sapiens	22-27
19331147-6	2009	The protein levels of Bcl-2 decreased and Bax increased in the mitochondrial fraction while the Bax protein decreased, and p53 and cytochrome c protein levels increased in the cytosolic fraction in HepG2 cells after capsaicin treatment for 24 h by Western blot.	Capsaicin	216-225	tumor protein p53	Homo sapiens	123-126
19331147-6	2009	The protein levels of Bcl-2 decreased and Bax increased in the mitochondrial fraction while the Bax protein decreased, and p53 and cytochrome c protein levels increased in the cytosolic fraction in HepG2 cells after capsaicin treatment for 24 h by Western blot.	Capsaicin	216-225	cytochrome c, somatic	Homo sapiens	131-143
19331147-7	2009	Immunostaining and confocal microscopic analysis also showed that capsaicin promoted cytoplasmic GADD153 expression and GRP78 nuclear translocation.	Capsaicin	66-75	DNA damage inducible transcript 3	Homo sapiens	97-104
19331147-7	2009	Immunostaining and confocal microscopic analysis also showed that capsaicin promoted cytoplasmic GADD153 expression and GRP78 nuclear translocation.	Capsaicin	66-75	heat shock protein family A (Hsp70) member 5	Homo sapiens	120-125
19331147-8	2009	The caspase-3 activity significantly increased after capsaicin treatment for 24 h. Our results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.	Capsaicin	53-62	caspase 3	Homo sapiens	4-13
19331147-8	2009	The caspase-3 activity significantly increased after capsaicin treatment for 24 h. Our results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.	Capsaicin	53-62	BCL2 apoptosis regulator	Homo sapiens	268-273
19331147-8	2009	The caspase-3 activity significantly increased after capsaicin treatment for 24 h. Our results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.	Capsaicin	53-62	caspase 3	Homo sapiens	304-313
19331147-8	2009	The caspase-3 activity significantly increased after capsaicin treatment for 24 h. Our results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.	Capsaicin	114-123	caspase 3	Homo sapiens	4-13
19331147-8	2009	The caspase-3 activity significantly increased after capsaicin treatment for 24 h. Our results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.	Capsaicin	114-123	BCL2 apoptosis regulator	Homo sapiens	268-273
19331147-8	2009	The caspase-3 activity significantly increased after capsaicin treatment for 24 h. Our results indicated that the capsaicin-induced apoptosis in HepG2 cells may result from the elevation of intracellular Ca2+ production, ROS, disruption of alpha psi(m), regulation of Bcl-2 family protein expression and caspase-3 activity.	Capsaicin	114-123	caspase 3	Homo sapiens	304-313
18839303-5	2009	TRPV1 knockouts displayed reduced oral avoidance responses to ethanol regardless of concentration, insensitivity to capsaicin, and little to no difference in sweet or bitter taste responding relative to wild type mice.	Capsaicin	116-125	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
19152548-0	2009	Capsaicin- and mustard oil-induced extracellular signal-regulated protein kinase phosphorylation in sensory neurons in vivo: effects of neurokinins 1 and 2 receptor antagonists and of a nitric oxide synthase inhibitor.	Capsaicin	0-9	tachykinin receptor 1	Rattus norvegicus	136-164
19152548-1	2009	Stimulation of primary sensory neurons with capsaicin or mustard oil leads to phosphorylation of extracellular signal-regulated protein kinase 1/2 (p-ERK1/2) via activation of transient receptor potential V1 (TRPV1) or TRPA1, respectively.	Capsaicin	44-53	mitogen activated protein kinase 3	Rattus norvegicus	150-156
19152548-1	2009	Stimulation of primary sensory neurons with capsaicin or mustard oil leads to phosphorylation of extracellular signal-regulated protein kinase 1/2 (p-ERK1/2) via activation of transient receptor potential V1 (TRPV1) or TRPA1, respectively.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	176-207
19152548-1	2009	Stimulation of primary sensory neurons with capsaicin or mustard oil leads to phosphorylation of extracellular signal-regulated protein kinase 1/2 (p-ERK1/2) via activation of transient receptor potential V1 (TRPV1) or TRPA1, respectively.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	209-214
19152548-1	2009	Stimulation of primary sensory neurons with capsaicin or mustard oil leads to phosphorylation of extracellular signal-regulated protein kinase 1/2 (p-ERK1/2) via activation of transient receptor potential V1 (TRPV1) or TRPA1, respectively.	Capsaicin	44-53	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	219-224
19152548-4	2009	The increase of p-ERK1/2 after systemic capsaicin treatment was markedly attenuated by SR140333, while only the increase in the dorsal root ganglia was impaired by SR48968; in contrast, inhibition of nitric oxide synthase had no effect.	Capsaicin	40-49	mitogen activated protein kinase 3	Rattus norvegicus	18-24
19152548-5	2009	Perineural capsaicin induced an increase in p-ERK1/2 in the ipsilateral sciatic nerve and in the dorsal root ganglia.	Capsaicin	11-20	mitogen activated protein kinase 3	Rattus norvegicus	46-52
19152548-8	2009	From the present results, it may be assumed that capsaicin- or mustard oil-induced p-ERK1/2 in sensory neurons is not solely directly linked to TRPV1 or TRPA1 channels, but under certain conditions NK(1)- and NK(2)-mediated mechanisms are involved.	Capsaicin	49-58	mitogen activated protein kinase 3	Rattus norvegicus	85-91
19152548-8	2009	From the present results, it may be assumed that capsaicin- or mustard oil-induced p-ERK1/2 in sensory neurons is not solely directly linked to TRPV1 or TRPA1 channels, but under certain conditions NK(1)- and NK(2)-mediated mechanisms are involved.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-149
19152548-8	2009	From the present results, it may be assumed that capsaicin- or mustard oil-induced p-ERK1/2 in sensory neurons is not solely directly linked to TRPV1 or TRPA1 channels, but under certain conditions NK(1)- and NK(2)-mediated mechanisms are involved.	Capsaicin	49-58	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	153-158
19381455-10	2009	Treatment with capsaicin induced a dramatic increase in caspase 3 activity, as assessed by the cleavage of Ac-DEVD-AMC, a fluorogenic substrate.	Capsaicin	15-24	caspase 3	Homo sapiens	56-65
19476209-5	2009	Remarkably, these aDRG NSCs expressed sensory neuronal markers vesicular glutamate transporter 2 (VGluT2--glutamate terminals), transient receptor potential vanilloid 1 (TrpV1--capsaicin sensitive), phosphorylated 200 kDa neurofilaments (pNF200--capsaicin insensitive, myelinated), and the serotonin transporter (5-HTT), which normally is transiently expressed in developing DRG.	Capsaicin	177-186	transient receptor potential cation channel subfamily V member 1	Homo sapiens	170-175
18594983-0	2009	Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.	Capsaicin	142-151	histamine receptor H 2	Rattus norvegicus	96-117
19275664-4	2009	Initially, the focus was on the development of TRPV1 agonists e.g. capsaicin and resiniferatoxin (RTX) as analgesic agents through the desensitization/denervation approach.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
19860701-4	2009	CGRP is considered a marker of afferent fibers in the upper gastrointestinal tract being almost completely depleted following treatment with the selective neurotoxin capsaicin that targets these fibers via transient receptor potential vanilloid of type-1.	Capsaicin	166-175	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	0-4
19063991-1	2009	TRPV1 is a noxious heat, capsaicin (vanilloid) and acid receptor for which the development of antagonists represents a novel therapeutic approach for the treatment of pain.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
20203492-3	2009	RESULTS: Capsaicin (TRPV1) receptor channels are expressed along the axonal membrane and respond to acidic, thermal and capsaicin stimulation with a graded and calcium-dependent calcitonin gene-related peptide release.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
20203492-3	2009	RESULTS: Capsaicin (TRPV1) receptor channels are expressed along the axonal membrane and respond to acidic, thermal and capsaicin stimulation with a graded and calcium-dependent calcitonin gene-related peptide release.	Capsaicin	120-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
18825335-5	2009	Much interest has been directed to the study of the TRPV1, because capsaicin has been instrumental in discovering the unique role of a subset of primary sensory neurons in causing nociceptive responses, in activating reflex pathways including cough, and in producing neurogenic inflammation.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
19296048-11	2009	Capsaicin administration inhibited the stimulated gastrin and histamine secretion and reversed the suppression of somatostatin secretion mediated by vagal stimulation.	Capsaicin	0-9	gastrin	Rattus norvegicus	50-57
19125874-10	2009	RESULTS: Injection of tumor necrosis factor-alpha, a cytokine implicated in the pathology of acute sinusitis and allergic rhinitis, into the V2 region was shown to lower the amount of capsaicin required to stimulate neurons located in the V1 region of the ganglion.	Capsaicin	184-193	tumor necrosis factor	Rattus norvegicus	22-49
19125874-13	2009	Pretreatment with tonabersat inhibited gap junction communication between neurons and satellite glia and blocked the increase in connexin 26 and active p38 levels in response to injection of both tumor necrosis factor-alpha (V2) and capsaicin (V1).	Capsaicin	233-242	gap junction protein, beta 2	Rattus norvegicus	129-140
19125874-14	2009	CONCLUSIONS: We propose that increased levels of tumor necrosis factor-alpha, as reported during acute sinusitis and allergic rhinitis, reduces the amount of capsaicin necessary to stimulate V1 neurons that leads to cellular changes in both V1 and V2 regions.	Capsaicin	158-167	tumor necrosis factor	Rattus norvegicus	49-76
20377371-5	2009	Functionally, enkephalin vector-treated animals showed reductions in bladder hyperactivity and nociceptive behavior induced by intravesical application of capsaicin; however, vector-mediated expression of enkephalin did not alter normal voiding.	Capsaicin	155-164	proenkephalin	Rattus norvegicus	14-24
19607967-6	2009	Mice lacking PKR genes exhibit impaired Bv8-induced hyperalgesia, develop deficient responses to noxious heat, capsaicin, and protons and show reduced thermal and mechanical hypersensitivity to paw inflammation, indicating a requirement for PKR signaling in activation and sensitization of primary afferent fibers.	Capsaicin	111-120	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	13-16
19012737-7	2009	In RTX-treated or dorsal rhizotomized rats, capsaicin still increased the frequency of spontaneous excitatory post-synaptic currents and miniature excitatory post-synaptic currents in the majority of neurons examined, and this effect was abolished by a TRPV1 blocker or by non-NMDA receptor antagonist.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	253-258
18564281-13	2009	In the study phase 2, capsaicin appeared to boost the factor XIIIa-positive dendrocytes, the thrombomodulin-positive cells and the blood vessel network as well.	Capsaicin	22-31	coagulation factor XIII A chain	Homo sapiens	54-66
18564281-13	2009	In the study phase 2, capsaicin appeared to boost the factor XIIIa-positive dendrocytes, the thrombomodulin-positive cells and the blood vessel network as well.	Capsaicin	22-31	thrombomodulin	Homo sapiens	93-107
19862936-0	2009	COX-2 inhibition attenuates cough reflex sensitivity to inhaled capsaicin in patients with asthma.	Capsaicin	64-73	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	0-5
19358815-8	2009	Evidence in support of this last hypothesis comes from down regulation of capsaicin-induced CGRP release in spinal cord slices and Dorsal Root Ganglia (DRG) neurons in culture after treatment with CB2 selective agonists.	Capsaicin	74-83	calcitonin related polypeptide alpha	Homo sapiens	92-96
19358815-8	2009	Evidence in support of this last hypothesis comes from down regulation of capsaicin-induced CGRP release in spinal cord slices and Dorsal Root Ganglia (DRG) neurons in culture after treatment with CB2 selective agonists.	Capsaicin	74-83	cannabinoid receptor 2	Homo sapiens	197-200
18949517-2	2009	The aim of the study was to evaluate cough reflex sensitivity to capsaicin in current and former smokers with COPD and examine its association with potentially protussive mediators.	Capsaicin	65-74	COPD	Homo sapiens	110-114
18930149-3	2009	Pharmacological stimulation of TRPV1 channels with capsaicin (10 nM) selectively enhanced the frequency of glutamate-mediated spontaneous (sEPSCs) and miniature excitatory postsynaptic currents (mEPSCs) recorded from putative striatal medium spiny neurons.	Capsaicin	51-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
18930149-5	2009	Consistently, the totality of striatal neurons responded to capsaicin (10 nM or 10 microM) after prevention of desensitization of TRPV1 channels with the protein kinase C (PKC) activator phorbol 12-myristate 13-acetate (PMA).	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-135
18930149-7	2009	The effects of capsaicin and of PMA were absent after pharmacological or genetic inactivation of TRPV1 channels.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
19010598-1	2009	TrpV1, the receptor for capsaicin, contributes to nociception in animals but appears to be much more important for signaling increased behavioral sensitivity in the injured state.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
19898681-8	2009	After a noxious stimulus (e.g., capsaicin injection) or tissue injury, c-Fos begins to be induced after 30-60 minutes, whereas pERK can be induced within a minute, which can correlate well with the development of pain hypersensitivity.	Capsaicin	32-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
19096234-2	2009	In sensory neurons of rat embryos, dorsal root ganglion (DRG) in culture, nefopam (3-30 mumol/l) and capsazepine (TRPV1 antagonist, 10 mumol/l) prevented intracellular calcium elevation and calcitonin gene-related peptide release induced by vanilloid agonist capsaicin.	Capsaicin	259-268	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	114-119
19081190-0	2009	Polymorphisms in the GTP cyclohydrolase gene (GCH1) are associated with ratings of capsaicin pain.	Capsaicin	83-92	GTP cyclohydrolase 1	Homo sapiens	46-50
19081190-4	2009	The current investigation analyzed the association of five previously identified GCH1 SNPs with ratings of pain induced by topical high concentration (10%) capsaicin applied to the skin of 39 healthy human volunteers.	Capsaicin	156-165	GTP cyclohydrolase 1	Homo sapiens	81-85
19081190-7	2009	We conclude that SNPs of the GCH1 gene may profoundly affect the ratings of pain induced by capsaicin.	Capsaicin	92-101	GTP cyclohydrolase 1	Homo sapiens	29-33
19091468-1	2009	Pituitary adenylate cyclase-activating polypeptide-38 (PACAP-38) and its receptors have been shown in the spinal dorsal horn, on capsaicin-sensitive sensory neurons and inflammatory cells.	Capsaicin	129-138	adenylate cyclase activating polypeptide 1	Rattus norvegicus	55-60
18996081-1	2008	Transient receptor potential vanilloid 1 (TRPV1) functions as a polymodal nociceptor and is activated by several vanilloids, including capsaicin, protons and heat.	Capsaicin	135-144	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-40
18996081-1	2008	Transient receptor potential vanilloid 1 (TRPV1) functions as a polymodal nociceptor and is activated by several vanilloids, including capsaicin, protons and heat.	Capsaicin	135-144	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
18996081-4	2008	Capsaicin induced severe neuronal death with apoptotic features, which was completely inhibited by the TRPV1 antagonist capsazepine and was dependent on extracellular Ca(2+) influx.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-108
18996081-6	2008	ERK inhibitor PD98059 and several antioxidants, but not the JNK and p38 inhibitors, attenuated capsaicin cytotoxicity.	Capsaicin	95-104	Eph receptor B1	Rattus norvegicus	0-3
19002586-5	2008	Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.	Capsaicin	39-48	BCL2 associated X, apoptosis regulator	Homo sapiens	98-101
18952063-1	2008	We previously found that capsaicin induces tight-junction (TJ) opening accompanied with cofilin dephosphorylation/activation in intestinal Caco-2 cells.	Capsaicin	25-34	cofilin 1	Homo sapiens	88-95
19002586-5	2008	Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.	Capsaicin	39-48	BCL2 apoptosis regulator	Homo sapiens	122-127
19002586-5	2008	Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.	Capsaicin	39-48	cytochrome c, somatic	Homo sapiens	165-177
19002586-5	2008	Exposure of AsPC-1 and BxPC-3 cells to capsaicin was also associated with increased expression of Bax, down-regulation of bcl-2, survivin and significant release of cytochrome c and AIF in the cytosol.	Capsaicin	39-48	apoptosis inducing factor mitochondria associated 1	Homo sapiens	182-185
19002586-7	2008	Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	50-53
19002586-7	2008	Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	58-61
19002586-7	2008	Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis.	Capsaicin	109-118	mitogen-activated protein kinase 8	Homo sapiens	50-53
19002586-7	2008	Capsaicin-treatment resulted in the activation of JNK and JNK inhibitor SP600125 afforded protection against capsaicin-induced apoptosis.	Capsaicin	109-118	mitogen-activated protein kinase 8	Homo sapiens	58-61
19002586-9	2008	Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.	Capsaicin	12-21	mitogen-activated protein kinase 8	Mus musculus	108-111
19002586-9	2008	Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.	Capsaicin	12-21	BCL2-associated X protein	Mus musculus	158-161
19002586-9	2008	Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.	Capsaicin	12-21	cytochrome c, somatic	Homo sapiens	163-175
19002586-9	2008	Tumors from capsaicin treated mice demonstrated increased apoptosis, which was related to the activation of JNK and increased cytosolic protein expression of Bax, cytochrome c, AIF and cleaved caspase-3, as compared with controls.	Capsaicin	12-21	apoptosis-inducing factor, mitochondrion-associated 1	Mus musculus	177-180
18806809-1	2008	The transient receptor potential vanilloid-1 (TRPV1) cation channel is a receptor that is activated by heat (>42 degrees C), acidosis (pH<6) and a variety of chemicals among which capsaicin is the best known.	Capsaicin	186-195	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
18806809-1	2008	The transient receptor potential vanilloid-1 (TRPV1) cation channel is a receptor that is activated by heat (>42 degrees C), acidosis (pH<6) and a variety of chemicals among which capsaicin is the best known.	Capsaicin	186-195	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-44
19085565-2	2008	Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsaicin, resiniferatoxin, and protons.	Capsaicin	99-108	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-40
18709364-1	2008	Capsaicin activates the transient receptor potential vanilloid 1 receptor (TRPV1) on small sensory afferents, and capsaicin is commonly used to elucidate mechanisms of neuropathic pain.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-73
18709364-1	2008	Capsaicin activates the transient receptor potential vanilloid 1 receptor (TRPV1) on small sensory afferents, and capsaicin is commonly used to elucidate mechanisms of neuropathic pain.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-80
19085565-2	2008	Transient receptor potential vanilloid-1 (TRPV1) is an ion channel activated by the tussive agents capsaicin, resiniferatoxin, and protons.	Capsaicin	99-108	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
19085565-6	2008	However, both dexbrompheniramine and chlorpheniramine significantly inhibited capsaicin-evoked responses in hTRPV1-HEK.	Capsaicin	78-87	transient receptor potential cation channel subfamily V member 1	Homo sapiens	108-114
19014389-3	2008	Lysophosphatidic acid production was induced by treatment of spinal cord slices with capsaicin (10 microM), an intense stimulator of primary afferents, in the presence of recombinant autotaxin, but not in its absence.	Capsaicin	85-94	ectonucleotide pyrophosphatase/phosphodiesterase 2	Homo sapiens	183-192
18829846-1	2008	TRPV1 receptors are activated and/or modulated by noxious heat, capsaicin, protons and other endogenous agents released following tissue injury.	Capsaicin	64-73	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
18832423-9	2008	In conclusion, allergen-induced airway inflammation clearly elevated capsaicin sensitivity in myelinated pulmonary afferents, which probably resulted from an increased expression of TRPV1 in these sensory nerves.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	182-187
18593740-6	2008	Additionally, we demonstrated that exposure of bilateral renal denervated or of renal chronic capsaicin-treated rats to a similar experimental protocol results in a fast and high rise in rectal temperature response, and this is associated with a significant increase in the basal serine phosphorylation and protein levels of Akt and protein levels of UCP1.	Capsaicin	94-103	AKT serine/threonine kinase 1	Rattus norvegicus	325-328
18701354-0	2008	Sensitization of primary afferent nociceptors induced by intradermal capsaicin involves the peripheral release of calcitonin gene-related Peptide driven by dorsal root reflexes.	Capsaicin	69-78	calcitonin-related polypeptide alpha	Rattus norvegicus	114-145
18701354-3	2008	The present study assessed the role of calcitonin gene-related peptide (CGRP) in sensitization of primary afferent nociceptors induced by activation of transient receptor potential vanilloid-1 (TRPV(1)) after intradermal injection of capsaicin and determined if this release is due to activation of primary afferent neurons antidromically by triggering of DRRs.	Capsaicin	234-243	calcitonin-related polypeptide alpha	Rattus norvegicus	72-76
18701354-3	2008	The present study assessed the role of calcitonin gene-related peptide (CGRP) in sensitization of primary afferent nociceptors induced by activation of transient receptor potential vanilloid-1 (TRPV(1)) after intradermal injection of capsaicin and determined if this release is due to activation of primary afferent neurons antidromically by triggering of DRRs.	Capsaicin	234-243	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	152-192
18701354-3	2008	The present study assessed the role of calcitonin gene-related peptide (CGRP) in sensitization of primary afferent nociceptors induced by activation of transient receptor potential vanilloid-1 (TRPV(1)) after intradermal injection of capsaicin and determined if this release is due to activation of primary afferent neurons antidromically by triggering of DRRs.	Capsaicin	234-243	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	194-201
18701354-6	2008	In dorsal root intact rats, peripheral pretreatment with a CGRP receptor antagonist could dose-dependently reduce the capsaicin-induced sensitization.	Capsaicin	118-127	calcitonin-related polypeptide alpha	Rattus norvegicus	59-63
18701354-7	2008	Peripheral post-treatment with CGRP could dose-dependently restore the capsaicin-induced sensitization under dorsal rhizotomized conditions.	Capsaicin	71-80	calcitonin-related polypeptide alpha	Rattus norvegicus	31-35
18701354-8	2008	Capsaicin injection evoked increases in numbers of single and double labeled TRPV(1) and CGRP neurons in ipsilateral dorsal root ganglia (DRG).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	77-84
18701354-8	2008	Capsaicin injection evoked increases in numbers of single and double labeled TRPV(1) and CGRP neurons in ipsilateral dorsal root ganglia (DRG).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
18593740-6	2008	Additionally, we demonstrated that exposure of bilateral renal denervated or of renal chronic capsaicin-treated rats to a similar experimental protocol results in a fast and high rise in rectal temperature response, and this is associated with a significant increase in the basal serine phosphorylation and protein levels of Akt and protein levels of UCP1.	Capsaicin	94-103	uncoupling protein 1	Rattus norvegicus	351-355
19112407-7	2008	The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin.	Capsaicin	163-172	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	31-34
19112407-7	2008	The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin.	Capsaicin	163-172	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	44-47
19112407-7	2008	The elevation of the levels of VR1 mRNA and VR1 protein induced by exogenous galanin implicated that VR1 may be involved in the mechanisms of SP release evoked by capsaicin.	Capsaicin	163-172	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	44-47
18804451-5	2008	In a heterologous expression system the Y511A point mutation in the vanilloid pocket of TRPV1 did not affect saccharin and aspartame responses but abolished cyclamate and acesulfame-K activities.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	88-93
18809416-0	2008	Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	19-24
18809416-0	2008	Phosphorylation of TRPV1 by neurokinin-1 receptor agonist exaggerates the capsaicin-mediated substance P release from cultured rat dorsal root ganglion neurons.	Capsaicin	74-83	tachykinin receptor 1	Rattus norvegicus	28-49
18809416-1	2008	The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmunoassay.	Capsaicin	139-148	tachykinin receptor 1	Rattus norvegicus	71-92
18809416-1	2008	The present study was conducted to determine whether the activation of neurokinin-1 receptor (NK-1R) by its agonist (GR73632) enhances the capsaicin-evoked substance P (SP) release using a radioimmunoassay.	Capsaicin	139-148	tachykinin receptor 1	Rattus norvegicus	94-99
18809416-8	2008	These findings suggest that the activation of NK-1R by its agonist, by sensitizing the TRPV1 through the PKC phosphorylation of TRPV1, may play a role in the enhancement of the capsaicin-evoked SP release from cultured rat DRG neurons.	Capsaicin	177-186	tachykinin receptor 1	Rattus norvegicus	46-51
18809416-8	2008	These findings suggest that the activation of NK-1R by its agonist, by sensitizing the TRPV1 through the PKC phosphorylation of TRPV1, may play a role in the enhancement of the capsaicin-evoked SP release from cultured rat DRG neurons.	Capsaicin	177-186	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-92
18809416-8	2008	These findings suggest that the activation of NK-1R by its agonist, by sensitizing the TRPV1 through the PKC phosphorylation of TRPV1, may play a role in the enhancement of the capsaicin-evoked SP release from cultured rat DRG neurons.	Capsaicin	177-186	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	128-133
18703328-8	2008	A new series of capsaicin concentrations was chosen for Maxin MA3.	Capsaicin	16-25	PNMA family member 3	Homo sapiens	62-65
19288899-9	2008	The number of c-fos positive neurons in the I-II layers of cSTN was obviously increased following EA at ST2, being significant more than that in control, vehicle, capsaicin and sham groups (P<0.01 respectively).	Capsaicin	163-172	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
19288899-11	2008	In capsaicin + EA group, the number of c-fos-IR positive neurons in the I-II layers of cSTN was obviously less than that in vehicle and vehicle + EA groups (P<0.01), but no significant changes were found in III-IV layers of cSTN.	Capsaicin	3-12	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	39-44
18687398-12	2009	After recovery from colitis, capsaicin-induced behavioral pain responses and spinal cord c-Fos expression were more pronounced in female GRK6-/- than WT mice.	Capsaicin	29-38	G protein-coupled receptor kinase 6	Mus musculus	137-141
18687398-14	2009	Capsaicin-induced referred hyperalgesia post-colitis was increased in GRK6-/- compared to WT mice.	Capsaicin	0-9	G protein-coupled receptor kinase 6	Mus musculus	70-74
19019214-7	2008	The ERK phosphorylation in Vc and C1-C2 neurons was strongly inhibited after subcutaneous injection of the capsaicin antagonist capsazepine in capsaicin-treated rats.	Capsaicin	107-116	Eph receptor B1	Rattus norvegicus	4-7
19019214-7	2008	The ERK phosphorylation in Vc and C1-C2 neurons was strongly inhibited after subcutaneous injection of the capsaicin antagonist capsazepine in capsaicin-treated rats.	Capsaicin	143-152	Eph receptor B1	Rattus norvegicus	4-7
19019214-8	2008	CONCLUSION: The present findings revealed that capsaicin treatment of the lateral facial skin causes an enhancement of ERK phosphorylation in Vc and C1-C2 neurons as well as induces nocifensive behavior to heat, cold and mechanical simulation of the capsaicin-treated skin.	Capsaicin	47-56	Eph receptor B1	Rattus norvegicus	119-122
19014578-3	2008	As CAP is a potent agonist of the transient receptor potential vanilloid receptor 1 (TRPV1) and no information was available of its expression in germ cells, we also studied the presence of TRPV1 in the cultured cells and in germ cells in situ.	Capsaicin	3-6	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	34-83
18775990-3	2008	Using patch clamp photometry, we found that the fraction of the total current carried by Ca2+ (called the Pf%) was significantly smaller for TRPV1 currents evoked by protons than for those evoked by capsaicin.	Capsaicin	199-208	transient receptor potential cation channel subfamily V member 1	Homo sapiens	141-146
18775990-1	2008	TRPV1 receptors are polymodal cation channels that open in response to diverse stimuli including noxious heat, capsaicin, and protons.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
19014578-3	2008	As CAP is a potent agonist of the transient receptor potential vanilloid receptor 1 (TRPV1) and no information was available of its expression in germ cells, we also studied the presence of TRPV1 in the cultured cells and in germ cells in situ.	Capsaicin	3-6	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	85-90
18987195-4	2008	Capsaicin-evoked CGRP release from spinal cord tissue and capsaicin-evoked action potentials on isolated skin-nerve preparation were significantly decreased in CB(1)KO mice.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	17-21
18987195-5	2008	Pretreatment with intraplantar galanin and bradykinin, compounds known to sensitize TRPV1 receptors, restored capsaicin-induced flinching in CB(1)KO mice.	Capsaicin	110-119	galanin and GMAP prepropeptide	Mus musculus	31-38
18987195-5	2008	Pretreatment with intraplantar galanin and bradykinin, compounds known to sensitize TRPV1 receptors, restored capsaicin-induced flinching in CB(1)KO mice.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	84-89
18632800-0	2008	TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
18983665-1	2008	BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and itching sensation (TRPV1-4).	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-152
18983665-1	2008	BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and itching sensation (TRPV1-4).	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
18983665-1	2008	BACKGROUND: Besides functioning as chemosensors for a broad range of endogenous and synthetic ligands, transient receptor potential vanilloid (TRPV) 1-4 channels have also been related to capsaicin (TRPV1), pain, and thermal stimuli perception, and itching sensation (TRPV1-4).	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	268-275
18983665-7	2008	The same qRT-PCR assay was used to compare TRPV1-4 expression between healthy controls and patients hyposensitive to capsaicin, pain and thermal stimuli: an almost doubled up-regulation of the TRPV1 gene was found in the pathological subjects.	Capsaicin	117-126	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-50
18632800-0	2008	TRPV1 mediates the uterine capsaicin-induced NMDA NR2B-dependent cross-organ reflex sensitization in anesthetized rats.	Capsaicin	27-36	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	50-54
18632800-3	2008	We tested the hypothesis that the excitation of capsaicin-sensitive primary afferent fibers arising from the uterus through the stimulation of transient receptor potential vanilloid 1 (TRPV1) induces cross-organ sensitization on the pelvic-urethra reflex activity.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	143-183
18632800-3	2008	We tested the hypothesis that the excitation of capsaicin-sensitive primary afferent fibers arising from the uterus through the stimulation of transient receptor potential vanilloid 1 (TRPV1) induces cross-organ sensitization on the pelvic-urethra reflex activity.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	185-190
18632800-5	2008	Activation of capsaicin-sensitive primary afferent fibers by capsaicin instillation into the uterine horn sensitized the pelvic-urethra reflex activity that was reversed by an intrauterine pretreatment with capsaizepine, a TRPV1-selective antagonist.	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	223-228
18632800-5	2008	Activation of capsaicin-sensitive primary afferent fibers by capsaicin instillation into the uterine horn sensitized the pelvic-urethra reflex activity that was reversed by an intrauterine pretreatment with capsaizepine, a TRPV1-selective antagonist.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	223-228
18632800-7	2008	These results demonstrated that TRPV1 plays a crucial role in contributing to the capsaicin-sensitive primary afferent fibers mediating the glutamatergic NMDA-dependent cross-organ sensitization between the uterus and the lower urinary tract when there is a tissue injury.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-37
18695637-5	2008	The potentiation by PEA and OEA was endothelium-independent and abolished by treatment with capsaicin (10 microM), which desensitizes the transient receptor potential vanilloid type 1 (TRPV1) receptor system, or by the TRPV1 receptor antagonist, N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791) (2 microM).	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	138-183
18818525-0	2008	Dihydrocapsaicin (DHC), a saturated structural analog of capsaicin, induces autophagy in human cancer cells in a catalase-regulated manner.	Capsaicin	7-16	catalase	Homo sapiens	113-121
18695637-5	2008	The potentiation by PEA and OEA was endothelium-independent and abolished by treatment with capsaicin (10 microM), which desensitizes the transient receptor potential vanilloid type 1 (TRPV1) receptor system, or by the TRPV1 receptor antagonist, N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791) (2 microM).	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	185-190
18695637-5	2008	The potentiation by PEA and OEA was endothelium-independent and abolished by treatment with capsaicin (10 microM), which desensitizes the transient receptor potential vanilloid type 1 (TRPV1) receptor system, or by the TRPV1 receptor antagonist, N-(3-methoxyphenyl)-4-chlorocinnamide (SB366791) (2 microM).	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	219-224
18509672-8	2008	These results indicate that SP mediates local responses to capsaicinoids through a mechanism involving coordinated activation of CFTR and K(+) channels.	Capsaicin	59-72	tachykinin 1	Mus musculus	28-30
18311519-5	2008	Basal SP and CGRP release and capsaicin-evoked SP and CGRP release were analyzed by radioimmunoassay (RIA).	Capsaicin	30-39	calcitonin related polypeptide alpha	Homo sapiens	54-58
18311519-8	2008	Capsaicin-evoked SP and CGRP release but not basal SP and CGRP release in neuromuscular co-cultures increased significantly as compared with that in the cultures of DRG explant alone.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	24-28
18689441-5	2008	Clinically relevant concentrations of isoflurane, sevoflurane, enflurane, and desflurane sensitize TRPV1 to capsaicin and protons and reduce the threshold for heat activation.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	99-104
19011674-4	2008	Capsaicin also markedly induced the phosphorylation of Akt.	Capsaicin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	55-58
19011674-5	2008	The phosphoinositide 3-kinase (PI3K) inhibitor LY294002 (10 micromol/L) prevented any capsaicin-induced survival effect in hippocampal neurons.	Capsaicin	86-95	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	4-29
19011674-7	2008	Taken together, these data suggest that capsaicin protects against H/R-induced apoptosis of hippocampal neurons via the PI3K/Akt-mediated signaling pathway, which is related to the inhibition of oxidative stress and caspase-3 activation.	Capsaicin	40-49	AKT serine/threonine kinase 1	Rattus norvegicus	125-128
19011674-7	2008	Taken together, these data suggest that capsaicin protects against H/R-induced apoptosis of hippocampal neurons via the PI3K/Akt-mediated signaling pathway, which is related to the inhibition of oxidative stress and caspase-3 activation.	Capsaicin	40-49	caspase 3	Rattus norvegicus	216-225
18617618-0	2008	17beta-estradiol activates estrogen receptor beta-signalling and inhibits transient receptor potential vanilloid receptor 1 activation by capsaicin in adult rat nociceptor neurons.	Capsaicin	138-147	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	74-123
18617618-3	2008	Here, we show that 17beta-estradiol acts directly on dorsal root ganglion (DRG) sensory neurons to reduce TRPV1 activation by capsaicin.	Capsaicin	126-135	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	106-111
18617618-4	2008	Capsaicin-induced cobalt uptake and the maximum TRPV1 current induced by capsaicin were inhibited when isolated cultured DRGs neurons from adult female rats were exposed to 17beta-estradiol (10-100 nm) overnight.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	48-53
18617618-4	2008	Capsaicin-induced cobalt uptake and the maximum TRPV1 current induced by capsaicin were inhibited when isolated cultured DRGs neurons from adult female rats were exposed to 17beta-estradiol (10-100 nm) overnight.	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	48-53
18617618-6	2008	Diarylpropionitrile (ERbeta agonist) also inhibited capsaicin-induced TRPV1 currents, whereas propylpyrazole triol (ERalpha agonist) and 17alpha-estradiol (inactive analog) were inactive, and 17beta-estradiol conjugated to BSA (membrane-impermeable agonist) caused a small increase.	Capsaicin	52-61	estrogen receptor 2	Rattus norvegicus	21-27
18617618-6	2008	Diarylpropionitrile (ERbeta agonist) also inhibited capsaicin-induced TRPV1 currents, whereas propylpyrazole triol (ERalpha agonist) and 17alpha-estradiol (inactive analog) were inactive, and 17beta-estradiol conjugated to BSA (membrane-impermeable agonist) caused a small increase.	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	70-75
18768735-1	2008	A remarkable new article in this issue of Molecular Pharmacology (p. 1261) shows that the capsaicin-sensitive ion channel TRPV1 is sensitized to activation by chemical and physical stimuli in the presence of inhaled general anesthetics.	Capsaicin	90-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
19674505-4	2008	While Cx26 plaque formation between neurons and satellite glia was transiently increased following capsaicin injections, Cx26 plaque formation between neurons and satellite glia was sustained in response to CFA.	Capsaicin	99-108	gap junction protein beta 2	Homo sapiens	6-10
19674505-5	2008	Interestingly, levels of Cx36 and Cx40 were only elevated in neurons following capsaicin or CFA injections, but the temporal response was similar to that observed for Cx26.	Capsaicin	79-88	gap junction protein delta 2	Homo sapiens	25-29
19674505-5	2008	Interestingly, levels of Cx36 and Cx40 were only elevated in neurons following capsaicin or CFA injections, but the temporal response was similar to that observed for Cx26.	Capsaicin	79-88	gap junction protein alpha 5	Homo sapiens	34-38
18509672-8	2008	These results indicate that SP mediates local responses to capsaicinoids through a mechanism involving coordinated activation of CFTR and K(+) channels.	Capsaicin	59-72	cystic fibrosis transmembrane conductance regulator	Mus musculus	129-133
18805596-1	2008	Agonists of the transient receptor potential vanilloid type 1 (TRPV1), such as capsaicin, cause pain and a drop in body temperature (hypothermia).	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-61
18991268-4	2008	The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.	Capsaicin	23-32	aldo-keto reductase family 1 member B	Homo sapiens	161-177
18991268-4	2008	The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.	Capsaicin	23-32	aldo-keto reductase family 1 member B	Homo sapiens	179-181
18991268-4	2008	The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.	Capsaicin	23-32	catalase	Homo sapiens	184-192
18991268-4	2008	The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.	Capsaicin	23-32	enolase 1	Homo sapiens	194-203
18991268-4	2008	The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.	Capsaicin	23-32	peroxiredoxin 1	Homo sapiens	205-220
18991268-4	2008	The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.	Capsaicin	23-32	peroxiredoxin 6	Homo sapiens	242-257
18991268-4	2008	The distinct effect of capsaicin-induced apoptosis on the expression pattern of HepG2 proteins includes the downregulation of some antioxidant enzymes including aldose reductase (AR), catalase, enolase 1, peroxiredoxin 1, but upregulation of peroxiredoxin 6, cytochrome c oxidase, and SOD2.	Capsaicin	23-32	superoxide dismutase 2	Homo sapiens	285-289
18991268-5	2008	In contrast, most antioxidant enzymes were increased in SK-N-SH cells in response to capsaicin, where catalase might play a pivotal role in maintenance of low ROS levels in the course of apoptosis.	Capsaicin	85-94	catalase	Homo sapiens	102-110
18805596-1	2008	Agonists of the transient receptor potential vanilloid type 1 (TRPV1), such as capsaicin, cause pain and a drop in body temperature (hypothermia).	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
18755179-3	2008	A robust increase in intracellular Ca(2+) was elicited by a variety of TRPV1 agonists with similar rank order of potency between both cultures: resiniferatoxin>tinyatoxin>capsaicin>N-arachidonoyl-dopamine (NADA).	Capsaicin	177-186	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	71-76
18468662-3	2008	Capsaicin (30 nM) and adenosine triphosphate (10 muM) were used to provoke CGRP release in the presence or absence of AJA.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	75-79
18468662-8	2008	The addition of adenosine triphosphate/capsaicin significantly increased the CGRP release over baseline, by 44% (P < .05), and AJA application significantly decreased CGRP release, by 29% compared with controls (P < .05).	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	77-81
18789837-5	2008	An intradermal injection of histamine and capsaicin, known to evoke predominantly itch and pain, respectively, in humans, each elicited hind limb scratching behavior when injected into the nape of the neck of the mouse.	Capsaicin	42-51	itchy E3 ubiquitin protein ligase	Homo sapiens	82-86
18782573-1	2008	Calcitonin gene-related peptide (CGRP), the major transmitter in capsaicin-sensitive sensory nerves, and asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase, participate in the regulation of blood pressure.	Capsaicin	65-74	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
18838811-2	2008	TRPV1 activation by the intake of capsaicin, the irritant in hot pepper, induces adrenaline secretion and increases energy consumption.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
18985006-0	2008	Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway.	Capsaicin	21-30	thymoma viral proto-oncogene 1	Mus musculus	104-107
18985006-0	2008	Inhibitory effect of capsaicin on B16-F10 melanoma cell migration via the phosphatidylinositol 3-kinase/Akt/Rac1 signal pathway.	Capsaicin	21-30	Rac family small GTPase 1	Mus musculus	108-112
18985006-5	2008	Although B16-F10 cell migration was increased by the PI3-K activator through the activation of Akt, these PI3-K activator-induced phenomena were attenuated by capsaicin.	Capsaicin	159-168	thymoma viral proto-oncogene 1	Mus musculus	95-98
18985006-6	2008	Moreover, capsaicin was found to significantly inhibit Rac1 activity in a pull-down assay.	Capsaicin	10-19	Rac family small GTPase 1	Mus musculus	55-59
18985006-7	2008	These results demonstrate that capsaicin inhibits the migration of B16-F10 cells through the inhibition of the PI3-K/Akt/Rac1 signal pathway.	Capsaicin	31-40	thymoma viral proto-oncogene 1	Mus musculus	117-120
18985006-7	2008	These results demonstrate that capsaicin inhibits the migration of B16-F10 cells through the inhibition of the PI3-K/Akt/Rac1 signal pathway.	Capsaicin	31-40	Rac family small GTPase 1	Mus musculus	121-125
18985006-8	2008	The present investigation suggests that capsaicin targets PI3-K/Akt/ Rac1-mediated cellular events in B16-F10 melanoma cells.	Capsaicin	40-49	thymoma viral proto-oncogene 1	Mus musculus	64-67
18985006-8	2008	The present investigation suggests that capsaicin targets PI3-K/Akt/ Rac1-mediated cellular events in B16-F10 melanoma cells.	Capsaicin	40-49	Rac family small GTPase 1	Mus musculus	69-73
18722504-1	2008	Local application of alphabetaMeATP (ligand for P2X3 receptors) and capsaicin (ligand for TRPV1 receptors) to the rat hindpaw produces pain behaviors (flinching) which are enhanced by noradrenaline (NA).	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	90-95
18958361-6	2008	Calcium imaging showed that isolated sensory neurons from ARTN-OE mice were hypersensitive to the TRPV1 agonist capsaicin and the TRPA1 agonist mustard oil.	Capsaicin	112-121	artemin	Mus musculus	58-62
18958361-6	2008	Calcium imaging showed that isolated sensory neurons from ARTN-OE mice were hypersensitive to the TRPV1 agonist capsaicin and the TRPA1 agonist mustard oil.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	98-103
18958361-7	2008	Behavioral testing of ARTN-OE mice also showed an increased sensitivity to heat, cold, capsaicin and mustard oil stimuli applied either to the skin or in the drinking water.	Capsaicin	87-96	artemin	Mus musculus	22-26
18958364-6	2008	Measuring the levels of SP and CGRP by radioimmunoassay, we demonstrated that capsaicin-stimulated release of neuropeptides is 3-5 folds higher in spinal cord slices from Nf1+/- mice than that from wildtype mouse tissue.	Capsaicin	78-87	trefoil factor 2 (spasmolytic protein 1)	Mus musculus	24-26
18958364-6	2008	Measuring the levels of SP and CGRP by radioimmunoassay, we demonstrated that capsaicin-stimulated release of neuropeptides is 3-5 folds higher in spinal cord slices from Nf1+/- mice than that from wildtype mouse tissue.	Capsaicin	78-87	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	31-35
18958364-6	2008	Measuring the levels of SP and CGRP by radioimmunoassay, we demonstrated that capsaicin-stimulated release of neuropeptides is 3-5 folds higher in spinal cord slices from Nf1+/- mice than that from wildtype mouse tissue.	Capsaicin	78-87	neurofibromin 1	Mus musculus	171-174
18958364-7	2008	In addition, the potassium- and capsaicin-stimulated release of CGRP from the culture of sensory neurons isolated from Nf1+/- mice was more than double that from the culture of wildtype neurons.	Capsaicin	32-41	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	64-68
18958364-7	2008	In addition, the potassium- and capsaicin-stimulated release of CGRP from the culture of sensory neurons isolated from Nf1+/- mice was more than double that from the culture of wildtype neurons.	Capsaicin	32-41	neurofibromin 1	Mus musculus	119-122
18809334-1	2008	Vanilloid agonists such as capsaicin activate ion flux through the TRPV1 channel, a heat- and ligand-gated cation channel that transduces painful chemical or thermal stimuli applied to peripheral nerve endings in skin or deep tissues.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
18809334-1	2008	Vanilloid agonists such as capsaicin activate ion flux through the TRPV1 channel, a heat- and ligand-gated cation channel that transduces painful chemical or thermal stimuli applied to peripheral nerve endings in skin or deep tissues.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
18584893-8	2008	Capsaicin increased the level of CGRP in the culture medium, and up-regulated the expression of CGRP in endothelial cells.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	33-37
18584893-8	2008	Capsaicin increased the level of CGRP in the culture medium, and up-regulated the expression of CGRP in endothelial cells.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	96-100
18584893-11	2008	Capsaicin significantly attenuated the endothelial cell damage induced by LPC, which was prevented and aggravated by capsazepine or CGRP(8-37,) antagonist of CGRP receptor.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	132-136
18584893-11	2008	Capsaicin significantly attenuated the endothelial cell damage induced by LPC, which was prevented and aggravated by capsazepine or CGRP(8-37,) antagonist of CGRP receptor.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	158-162
18650319-8	2008	Addition of exogenous CGRP (10(-9) M), release of endogenous CGRP with capsaicin, or repeated electrical stimulation recovered force to 50-70% of initial force (P < 0.001).	Capsaicin	71-80	calcitonin-related polypeptide alpha	Rattus norvegicus	61-65
18604228-10	2008	Finally, responses to basolateral BK in intact tissues were inhibited by tetrodotoxin (1 microM), atropine (1 microM), capsaicin (100 microM) and piroxicam (10 microM).	Capsaicin	119-128	kininogen 1	Homo sapiens	34-36
18809749-2	2008	We evaluated whether activation of the NPY Y1 receptor could modulate the activity of capsaicin-sensitive nociceptors in trigeminal ganglia and dental pulp.	Capsaicin	86-95	neuropeptide Y	Homo sapiens	39-42
18973552-0	2008	Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons.	Capsaicin	84-93	protein kinase C, epsilon	Rattus norvegicus	0-24
18973552-0	2008	Protein kinase C epsilon contributes to basal and sensitizing responses of TRPV1 to capsaicin in rat dorsal root ganglion neurons.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	75-80
18809749-3	2008	We tested this hypothesis by measuring capsaicin-stimulated calcitonin gene-related peptide release (CGRP) as a measure of nociceptor activity.	Capsaicin	39-48	calcitonin related polypeptide alpha	Homo sapiens	60-99
18806620-3	2008	Capsaicin (50 microg/kg)-induced depressor effects and increase in plasma calcitonin gene related peptide (CGRP) levels (-29 +/- 2 mmHg, 82.2 +/- 5.0 pg/ml) were abolished by a selective transient receptor potential vanilloid subtype 1 channel antagonist, capsazepine (3 mg/kg, -4 +/- 1 mmHg, 41.8 +/- 4.4 pg/ml, P < 0.01), and attenuated by a selective ryanodine receptor antagonist, dantrolene (5 mg/kg, -12 +/- 1 mmHg, 57.2 +/- 2.6 pg/ml, P < 0.01), but unaffected by an inhibitor of endoplasmic reticulum Ca-ATPase, thapsigargin (50 microg/kg, -30 +/- 1 mmHg, 73.8 +/- 2.3 pg/ml, P > 0.05), or an antagonist of the inositol (1,4,5)-trisphosphate receptor, 2-aminoethoxydiphenyl borate (3 mg/kg, -34 +/- 5 mmHg, 69.0 +/- 3.7 pg/ml, P > 0.05).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	74-105
18806620-3	2008	Capsaicin (50 microg/kg)-induced depressor effects and increase in plasma calcitonin gene related peptide (CGRP) levels (-29 +/- 2 mmHg, 82.2 +/- 5.0 pg/ml) were abolished by a selective transient receptor potential vanilloid subtype 1 channel antagonist, capsazepine (3 mg/kg, -4 +/- 1 mmHg, 41.8 +/- 4.4 pg/ml, P < 0.01), and attenuated by a selective ryanodine receptor antagonist, dantrolene (5 mg/kg, -12 +/- 1 mmHg, 57.2 +/- 2.6 pg/ml, P < 0.01), but unaffected by an inhibitor of endoplasmic reticulum Ca-ATPase, thapsigargin (50 microg/kg, -30 +/- 1 mmHg, 73.8 +/- 2.3 pg/ml, P > 0.05), or an antagonist of the inositol (1,4,5)-trisphosphate receptor, 2-aminoethoxydiphenyl borate (3 mg/kg, -34 +/- 5 mmHg, 69.0 +/- 3.7 pg/ml, P > 0.05).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	107-111
18809749-3	2008	We tested this hypothesis by measuring capsaicin-stimulated calcitonin gene-related peptide release (CGRP) as a measure of nociceptor activity.	Capsaicin	39-48	calcitonin related polypeptide alpha	Homo sapiens	101-105
18806620-4	2008	CGRP8-37 (1 mg/kg), a selective CGRP receptor antagonist, also blocked capsaicin-induced depressor effects.	Capsaicin	71-80	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
18809749-4	2008	Capsaicin-evoked CGRP release was inhibited by 50% (p < 0.05) in trigeminal ganglia and by 26% (p < 0.05) in dental pulp when tissues were pre-treated with [Leu(31),Pro(34)]NPY.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	17-21
18806620-6	2008	In vitro, capsaicin (0.3 micromol/l) increased intracellular Ca concentrations and CGRP release from freshly isolated sensory neurons in dorsal root ganglion (P < 0.01), which were blocked by capsazepine (10 micromol/l) and attenuated by dantrolene but not thapsigargin or 2-aminoethoxydiphenyl borate.	Capsaicin	10-19	calcitonin-related polypeptide alpha	Rattus norvegicus	83-87
18809749-4	2008	Capsaicin-evoked CGRP release was inhibited by 50% (p < 0.05) in trigeminal ganglia and by 26% (p < 0.05) in dental pulp when tissues were pre-treated with [Leu(31),Pro(34)]NPY.	Capsaicin	0-9	neuropeptide Y	Homo sapiens	179-182
18528757-4	2008	Thus, the studies of the functional regulation of TRPV1 are mainly focused on two aspects: to develop more potent analogues of capsaicin with less side effects; or to elucidate the mechanisms of TRPV1 in pain sensitivity, especially of that TRPV1 as a target of various protein kinases such as PKD1 and Cdk5 is involved pain hypersensitivity.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
18845912-2	2008	The SP released from cultured DRG neurons of Na(v)1.8 knock-out mice exposed to either capsaicin or KCl was significantly lower than that from wild-type (C57BL/6) mice based on a radioimmunoassay.	Capsaicin	87-96	tachykinin 1	Mus musculus	4-6
18845912-2	2008	The SP released from cultured DRG neurons of Na(v)1.8 knock-out mice exposed to either capsaicin or KCl was significantly lower than that from wild-type (C57BL/6) mice based on a radioimmunoassay.	Capsaicin	87-96	sodium channel, voltage-gated, type X, alpha	Mus musculus	45-53
19016376-9	2008	In addition, capsaicin, a stressor, which activates HSV in in vitro models of latency, decreased levels of Zhangfei and trkA transcripts in NGF-differentiated PC12 cells.	Capsaicin	13-22	CREB/ATF bZIP transcription factor	Homo sapiens	107-115
19016376-9	2008	In addition, capsaicin, a stressor, which activates HSV in in vitro models of latency, decreased levels of Zhangfei and trkA transcripts in NGF-differentiated PC12 cells.	Capsaicin	13-22	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	120-124
19016376-9	2008	In addition, capsaicin, a stressor, which activates HSV in in vitro models of latency, decreased levels of Zhangfei and trkA transcripts in NGF-differentiated PC12 cells.	Capsaicin	13-22	nerve growth factor	Rattus norvegicus	140-143
18660449-5	2008	Muscle vascular insufficiency was induced by the femoral artery ligation in rats for 24 h. Our data show that 1) the ligation surgery leads to the upregulation of TRPV1 expression in the dorsal root ganglion; 2) the magnitude of the dorsal root ganglion neuron TRPV1 response induced by capsaicin is greater in vascular insufficiency (4.0 +/- 0.31 nA, P < 0.05 vs. sham-operated control) than that in sham-operated control (2.9 +/- 0.23 nA); and 3) renal sympathetic nerve activity and mean arterial pressure responses to capsaicin (0.5 microg/kg body wt) are also enhanced by vascular insufficiency (54 +/- 11%, 9 +/- 2 mmHg in sham-operated controls vs. 98 +/- 13%, 33 +/- 5 mmHg after vascular insufficiency, P < 0.05).	Capsaicin	287-296	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	163-168
18826653-1	2008	The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamide, and phosphorylation by protein kinase C (PKC).	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	33-89
18826653-1	2008	The capsaicin receptor, known as transient receptor potential channel vanilloid subtype 1 (TRPV1), is activated by a wide range of noxious stimulants and putative ligands such as capsaicin, heat, pH, anandamide, and phosphorylation by protein kinase C (PKC).	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
18826653-7	2008	Mutagenesis of rat TRPV1 revealed that DAG-binding site is at Y511, the same site for capsaicin binding, and PtdIns(4,5)P2binding site may not be critical for the activation of rat TRPV1 by DAG in heterologous system.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	19-24
18588953-7	2008	In [(3)H]endomorphin-1 binding assays, capsazepine antagonized the inhibitory effect of capsaicin in rat brain membranes suggesting the involvement of TRPV1 receptors.	Capsaicin	88-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	151-156
18652806-0	2008	Overexpression of artemin in the tongue increases expression of TRPV1 and TRPA1 in trigeminal afferents and causes oral sensitivity to capsaicin and mustard oil.	Capsaicin	135-144	artemin	Mus musculus	18-25
18652806-7	2008	ART-OE afferents had larger calcium transients in response to ligands of TRPV1 (capsaicin) and TRPA1 (mustard oil).	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
18722778-2	2008	The tetrahydropyridine 6 is a novel TRPV1 receptor antagonist that potently inhibits receptor-mediated Ca2+ influx in vitro induced by several agonists, including capsaicin, N-arachidonoyldopamine (NADA), and low pH.	Capsaicin	163-172	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-41
18343036-5	2008	Surprisingly, TRPV1 function was also attenuated in P2Y(2)-/- mice, as measured by the frequency and magnitude of capsaicin responses in vitro and behavioral responses to capsaicin administration in vivo.	Capsaicin	114-123	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
18343036-5	2008	Surprisingly, TRPV1 function was also attenuated in P2Y(2)-/- mice, as measured by the frequency and magnitude of capsaicin responses in vitro and behavioral responses to capsaicin administration in vivo.	Capsaicin	171-180	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
18789524-2	2008	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release CGRP from their central and/or peripheral axons, suggesting a functional link between CGRP and the capsaicin receptor TRPV1.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	69-73
18789524-2	2008	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release CGRP from their central and/or peripheral axons, suggesting a functional link between CGRP and the capsaicin receptor TRPV1.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	155-159
18789524-2	2008	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release CGRP from their central and/or peripheral axons, suggesting a functional link between CGRP and the capsaicin receptor TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	187-192
18809208-7	2008	RESULTS: Both SNP and capsaicin caused significant increases in CGRP release.	Capsaicin	22-31	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
18574245-8	2008	Simultaneous confocal imaging and electrophysiological recording of whole cells expressing a rapamycin-inducible lipid phosphatase also demonstrates that depletion of PI(4,5)P(2) inhibits capsaicin-activated TRPV1 current; the PI(4)P generated by the phosphatases was not sufficient to support TRPV1 function.	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	208-213
18574245-8	2008	Simultaneous confocal imaging and electrophysiological recording of whole cells expressing a rapamycin-inducible lipid phosphatase also demonstrates that depletion of PI(4,5)P(2) inhibits capsaicin-activated TRPV1 current; the PI(4)P generated by the phosphatases was not sufficient to support TRPV1 function.	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	294-299
18799680-4	2008	In dorsal root ganglia (DRG) neurons of Nox1(+/Y), pretreatment with chemical mediators bradykinin, serotonin, or phorbol 12-myristate 13-acetate (PMA) augmented the capsaicin-induced calcium increase, whereas this increase was significantly attenuated in DRG neurons of Nox1(-/Y).	Capsaicin	166-175	NADPH oxidase 1	Mus musculus	40-44
18799680-4	2008	In dorsal root ganglia (DRG) neurons of Nox1(+/Y), pretreatment with chemical mediators bradykinin, serotonin, or phorbol 12-myristate 13-acetate (PMA) augmented the capsaicin-induced calcium increase, whereas this increase was significantly attenuated in DRG neurons of Nox1(-/Y).	Capsaicin	166-175	NADPH oxidase 1	Mus musculus	271-279
18692962-0	2008	Cannabinoid receptor CB2 localisation and agonist-mediated inhibition of capsaicin responses in human sensory neurons.	Capsaicin	73-82	cannabinoid receptor 2	Homo sapiens	21-24
18692962-4	2008	In primary cultures of human DRG neurons, selective CB2 agonists blocked activation of inward cation currents and elevation of cytoplasmic Ca2+ in response to capsaicin.	Capsaicin	159-168	cannabinoid receptor 2	Homo sapiens	52-55
18692962-7	2008	We conclude that CB2 agonists deserve imminent clinical trials for nociceptive, inflammatory and neuropathic chronic pain, in which capsaicin or heat-activated responses via TRPV1 may provide a clinical marker.	Capsaicin	132-141	cannabinoid receptor 2	Homo sapiens	17-20
18692962-7	2008	We conclude that CB2 agonists deserve imminent clinical trials for nociceptive, inflammatory and neuropathic chronic pain, in which capsaicin or heat-activated responses via TRPV1 may provide a clinical marker.	Capsaicin	132-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	174-179
18577691-3	2008	When compared with the baseline reflex activity (1.00 +/- 0.00 spikes/stimulation), uterine capsaicin instillation significantly increased reflex activity (45.42 +/- 9.13 spikes/stimulation, P < 0.01, n = 7) that was corroborated by an increase in phosphorylated NMDA NR2B (P < 0.05, n = 4) but not NR2A subunit (P > 0.05, n = 4) expression.	Capsaicin	92-101	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	271-275
18577691-3	2008	When compared with the baseline reflex activity (1.00 +/- 0.00 spikes/stimulation), uterine capsaicin instillation significantly increased reflex activity (45.42 +/- 9.13 spikes/stimulation, P < 0.01, n = 7) that was corroborated by an increase in phosphorylated NMDA NR2B (P < 0.05, n = 4) but not NR2A subunit (P > 0.05, n = 4) expression.	Capsaicin	92-101	glutamate ionotropic receptor NMDA type subunit 2A	Rattus norvegicus	305-309
18660449-5	2008	Muscle vascular insufficiency was induced by the femoral artery ligation in rats for 24 h. Our data show that 1) the ligation surgery leads to the upregulation of TRPV1 expression in the dorsal root ganglion; 2) the magnitude of the dorsal root ganglion neuron TRPV1 response induced by capsaicin is greater in vascular insufficiency (4.0 +/- 0.31 nA, P < 0.05 vs. sham-operated control) than that in sham-operated control (2.9 +/- 0.23 nA); and 3) renal sympathetic nerve activity and mean arterial pressure responses to capsaicin (0.5 microg/kg body wt) are also enhanced by vascular insufficiency (54 +/- 11%, 9 +/- 2 mmHg in sham-operated controls vs. 98 +/- 13%, 33 +/- 5 mmHg after vascular insufficiency, P < 0.05).	Capsaicin	525-534	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	163-168
18559878-4	2008	Functional characterization of TRPV1 mutants showed that substitution of I696, W697, and R701 by alanine severely affected voltage- and heat-dependent activation and notably reduced the capsaicin responsiveness and tachyphylaxia, while mutation of K698, L699, and Q700 had minor effects.	Capsaicin	186-195	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
18783367-4	2008	mRNA for enzymes in dorsal root ganglia involved in catecholamine uptake and metabolism, dopamine beta-hydroxylase and MAO-A, were decreased by neonatal administration of capsaicin.	Capsaicin	171-180	dopamine beta-hydroxylase	Rattus norvegicus	89-114
18783367-4	2008	mRNA for enzymes in dorsal root ganglia involved in catecholamine uptake and metabolism, dopamine beta-hydroxylase and MAO-A, were decreased by neonatal administration of capsaicin.	Capsaicin	171-180	monoamine oxidase A	Rattus norvegicus	119-124
18405883-7	2008	RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin.	Capsaicin	217-226	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	123-128
18777111-1	2008	The vanilloid receptor 1 (TRPV1) is activated by capsaicin, several endogenous lipids, acidic pH and elevated temperatures.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-24
18777111-1	2008	The vanilloid receptor 1 (TRPV1) is activated by capsaicin, several endogenous lipids, acidic pH and elevated temperatures.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
18777111-4	2008	Focal application of heated solutions demonstrated that the normal threshold (approximately 42 degrees C) of TRPV1 activation was reduced in the presence of capsaicin (1 microM) to approximately 30 degrees C. In current-clamp recordings, increasing the temperature of the solution resulted in larger membrane depolarizations and significantly altered the pattern and onset of the action potential train evoked by 1 microM capsaicin.	Capsaicin	157-166	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	109-114
18777111-4	2008	Focal application of heated solutions demonstrated that the normal threshold (approximately 42 degrees C) of TRPV1 activation was reduced in the presence of capsaicin (1 microM) to approximately 30 degrees C. In current-clamp recordings, increasing the temperature of the solution resulted in larger membrane depolarizations and significantly altered the pattern and onset of the action potential train evoked by 1 microM capsaicin.	Capsaicin	422-431	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	109-114
18515644-4	2008	At the recombinant human TRPV1 receptor ABT-102 potently (IC(50) = 5-7 nM) inhibits agonist (capsaicin, N-arachidonyl dopamine, anandamide, and proton)-evoked increases in intracellular Ca(2+) levels.	Capsaicin	93-102	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-30
18515644-5	2008	ABT-102 also potently (IC(50) = 1-16 nM) inhibits capsaicin-evoked currents in rat dorsal root ganglion (DRG) neurons and currents evoked through activation of recombinant rat TRPV1 currents by capsaicin, protons, or heat.	Capsaicin	194-203	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	176-181
24149904-10	2008	Key pointsObese individuals possess reduced cardiac autonomic nervous activities, especially sympathetic nervous activity associated with thermogenesis induced by capsaicin.Lower sympathetic nervous activity may associate with -866 G/A variants of UCP2 polymorphism.Capsaicin ingestion, however, may consider as a safe nutrient-aid with no adverse effects of cardiac electrical stability.	Capsaicin	266-275	uncoupling protein 2	Homo sapiens	248-252
18553211-0	2008	Regulation of galanin and galanin receptor 2 expression by capsaicin in primary cultured dorsal root ganglion neurons.	Capsaicin	59-68	galanin receptor 2	Homo sapiens	26-44
18553211-2	2008	Activation of galanin receptor 2 (GalR2) plays a pronociceptive role and enhances capsaicin-induced nociception in the periphery.	Capsaicin	82-91	galanin receptor 2	Homo sapiens	14-32
18553211-2	2008	Activation of galanin receptor 2 (GalR2) plays a pronociceptive role and enhances capsaicin-induced nociception in the periphery.	Capsaicin	82-91	galanin receptor 2	Homo sapiens	34-39
18553211-4	2008	Capsaicin evokes acute pain via activation of VR1 expressed in primary sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-49
18553211-5	2008	It is not known to what extent galanin and its receptor GalR2 expression is regulated by capsaicin in DRG neurons.	Capsaicin	89-98	galanin receptor 2	Homo sapiens	56-61
18553211-6	2008	Effects of acute (4 h) or chronic (4 d) treatment with capsaicin at different concentrations (0.01, 0.1, 1 micromol/L) on galanin and GalR2 expression in primary cultured DRG neurons were investigated in the present study.	Capsaicin	55-64	galanin receptor 2	Homo sapiens	134-139
18553211-8	2008	Only chronic exposure of 0.1 micromol/L concentration capsaicin could elevate GalR2 expression, whereas capsaicin did not have this effect at any other conditions in this experiment.	Capsaicin	54-63	galanin receptor 2	Homo sapiens	78-83
18553211-9	2008	These results indicated that certain concentrations or exposure time of capsaicin stimulation may be relevant to upregulation of galanin and its receptor GalR2 expression in DRG cultures suggesting a response to peripheral neuronal stimulation.	Capsaicin	72-81	galanin receptor 2	Homo sapiens	154-159
18553211-10	2008	And also, capsaicin-induced GalR2 expression may be also modulated by capsaicin-induced galanin expression.	Capsaicin	10-19	galanin receptor 2	Homo sapiens	28-33
18553211-10	2008	And also, capsaicin-induced GalR2 expression may be also modulated by capsaicin-induced galanin expression.	Capsaicin	70-79	galanin receptor 2	Homo sapiens	28-33
18553211-11	2008	The possible significance of the neurotransmission of nociceptive information involved in galanin or GalR2 expression caused by capsaicin is still to be clarified.	Capsaicin	128-137	galanin receptor 2	Homo sapiens	101-106
18405883-7	2008	RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
18405883-7	2008	RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	123-128
18405883-7	2008	RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	123-128
18405883-7	2008	RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin.	Capsaicin	217-226	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
18405883-7	2008	RESULTS: The TRPV1 agonists capsaicin and resiniferatoxin facilitated LTP but suppressed LTD. Alterations were mediated by TRPV1 because the TRPV1 selective antagonists capsazepine and SB366791 blocked the actions of capsaicin.	Capsaicin	217-226	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	123-128
18405883-8	2008	Acute stress suppressed LTP and enabled LTD, but the TRPV1 agonist capsaicin effectively prevented this effect.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	53-58
18582539-0	2008	Tumor necrosis factor alpha enhances the sensitivity of rat trigeminal neurons to capsaicin.	Capsaicin	82-91	tumor necrosis factor	Rattus norvegicus	0-27
18582539-2	2008	This study evaluated the hypothesis that TNFalpha increases the sensitivity of rat trigeminal neurons to capsaicin via two different mechanisms triggered by either brief or sustained exposure to the cytokine.	Capsaicin	105-114	tumor necrosis factor	Rattus norvegicus	41-49
18582539-3	2008	A brief (5 min) application of TNFalpha significantly sensitized capsaicin-evoked accumulation of intracellular calcium ([Ca2+]i) (226.4+/-37.7 nM vs. 167.5+/-31.3 nM) and increased capsaicin-evoked nocifensive behavior (78.3+/-9.7 vs. 30.9+/-3.6 s) as compared with vehicle pretreatment (P<0.01 for both).	Capsaicin	65-74	tumor necrosis factor	Rattus norvegicus	31-39
18582539-3	2008	A brief (5 min) application of TNFalpha significantly sensitized capsaicin-evoked accumulation of intracellular calcium ([Ca2+]i) (226.4+/-37.7 nM vs. 167.5+/-31.3 nM) and increased capsaicin-evoked nocifensive behavior (78.3+/-9.7 vs. 30.9+/-3.6 s) as compared with vehicle pretreatment (P<0.01 for both).	Capsaicin	182-191	tumor necrosis factor	Rattus norvegicus	31-39
18582539-5	2008	This long-term up-regulation of TRPV1 expression by TNFalpha correlated with enhancement in capsaicin-induced calcitonin gene-related peptide release (P<0.05).	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-37
18582539-5	2008	This long-term up-regulation of TRPV1 expression by TNFalpha correlated with enhancement in capsaicin-induced calcitonin gene-related peptide release (P<0.05).	Capsaicin	92-101	tumor necrosis factor	Rattus norvegicus	52-60
18582539-7	2008	In summary, our data demonstrate that TNFalpha directly enhances the sensitivity of rat trigeminal neurons to capsaicin via both rapid, non-genomic mechanisms as well as sustained genomic regulation in TRPV1 expression.	Capsaicin	110-119	tumor necrosis factor	Rattus norvegicus	38-46
18533110-0	2008	Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study.	Capsaicin	70-79	DNA damage inducible transcript 3	Homo sapiens	54-61
18959118-1	2008	BACKGROUND: Calcitonin gene-related peptide (CGRP) is the predominant neurotransmitter in capsaicin-sensitive sensory nerves.	Capsaicin	90-99	calcitonin related polypeptide alpha	Homo sapiens	12-43
18533110-0	2008	Induction of the endoplasmic reticulum stress protein GADD153/CHOP by capsaicin in prostate PC-3 cells: a microarray study.	Capsaicin	70-79	DNA damage inducible transcript 3	Homo sapiens	62-66
18533110-6	2008	We then tested the contribution of GADD153/CHOP to protection against capsaicin-induced cell death using RNA interference.	Capsaicin	70-79	DNA damage inducible transcript 3	Homo sapiens	35-42
18533110-7	2008	Blockage of GADD153/CHOP expression by small interfering RNA, significantly reduced capsaicin-induced cell death in PC-3 cells.	Capsaicin	84-93	DNA damage inducible transcript 3	Homo sapiens	12-19
18533110-7	2008	Blockage of GADD153/CHOP expression by small interfering RNA, significantly reduced capsaicin-induced cell death in PC-3 cells.	Capsaicin	84-93	DNA damage inducible transcript 3	Homo sapiens	20-24
18959118-1	2008	BACKGROUND: Calcitonin gene-related peptide (CGRP) is the predominant neurotransmitter in capsaicin-sensitive sensory nerves.	Capsaicin	90-99	calcitonin related polypeptide alpha	Homo sapiens	45-49
18567714-0	2008	N-oleoyldopamine, a novel endogenous capsaicin-like lipid, protects the heart against ischemia-reperfusion injury via activation of TRPV1.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	132-137
18321745-2	2008	We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans.	Capsaicin	49-58	insulin-like growth factor 1	Mus musculus	138-166
18924441-3	2008	In the GI tract of animals neuropeptides like tachykinins and calcitonin gene-related peptide (CGRP) mediate specific excitatory and inhibitory effects of capsaicin; some evidence indicates a participation of purinergic mechanisms as well.	Capsaicin	155-164	calcitonin related polypeptide alpha	Homo sapiens	62-93
18924441-3	2008	In the GI tract of animals neuropeptides like tachykinins and calcitonin gene-related peptide (CGRP) mediate specific excitatory and inhibitory effects of capsaicin; some evidence indicates a participation of purinergic mechanisms as well.	Capsaicin	155-164	calcitonin related polypeptide alpha	Homo sapiens	95-99
18392614-3	2008	Although the seal resistance was quite low (approximately 7 Mohms) compared with the pipette patch-clamp gigaohm seal, the whole-cell channel current of the transient receptor potential vanilloid type 1 (TRPV1) channel expressing HEK293 cells was successfully observed, with a good signal-to-noise ratio, using capsaicin as a ligand molecule.	Capsaicin	311-320	transient receptor potential cation channel subfamily V member 1	Homo sapiens	157-202
18392614-3	2008	Although the seal resistance was quite low (approximately 7 Mohms) compared with the pipette patch-clamp gigaohm seal, the whole-cell channel current of the transient receptor potential vanilloid type 1 (TRPV1) channel expressing HEK293 cells was successfully observed, with a good signal-to-noise ratio, using capsaicin as a ligand molecule.	Capsaicin	311-320	transient receptor potential cation channel subfamily V member 1	Homo sapiens	204-209
18218331-8	2008	Neurons lacking HCN-1 or HCN-2 channel isoforms were mostly capsaicin-positive and IB4-negative.	Capsaicin	60-69	hyperpolarization activated cyclic nucleotide gated potassium channel 1	Sus scrofa	16-21
18321745-2	2008	We recently reported that topical application of capsaicin increases facial skin elasticity and promotes hair growth by increasing dermal insulin-like growth factor-I (IGF-I) production through activation of sensory neurons in mice and humans.	Capsaicin	49-58	insulin-like growth factor 1	Mus musculus	168-173
18561998-8	2008	Additionally, the enhanced NO synthesis caused by capsaicin was abrogated by co-treatment with capsazepine, illustrating that NOS activity could be modulated by TRPV1.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	161-166
18414789-3	2008	We studied the effects of Ara C on human dorsal root ganglion (DRG) neurons, especially the expression and sensitivity of the ion channel TRPV1, which responds to noxious heat and capsaicin and is a key mediator of neuropathic pain.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	138-143
18414789-9	2008	CONCLUSIONS: It is postulated that Ara C treatment blocked insertion of TRPV1 in the cell membrane, resulting in accumulation of the receptors in the cytoplasm, loss of capsaicin sensitivity, and membrane-bound immunostaining, which was restored with a rebound on withdrawal of Ara C.	Capsaicin	169-178	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
18499726-1	2008	Transient receptor potential (TRP) A1 channels are cation channels found preferentially on nociceptive sensory neurones, including capsaicin-sensitive TRPV1-expressing vagal bronchopulmonary C-fibres, and are activated by electrophilic compounds such as mustard oil and cinnamaldehyde.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	151-156
18554636-11	2008	CONCLUSIONS: Intraprostatic capsaicin injection activates cyclooxygenase-2 expression in the prostate, and spinal sensory and motor neurons, and it induces prostatic pain.	Capsaicin	28-37	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	58-74
18554636-12	2008	Botulinum toxin A pretreatment could inhibit capsaicin induced cyclooxygenase-2 expression from the peripheral organ to the L6 spinal cord and inhibit prostatic pain and inflammation.	Capsaicin	45-54	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	63-79
18063480-9	2008	Electrophysiological measurements indicated that DRG with overexpression of PKD1 were more sensitive to low dose capsaicin than those expressing DN-PKD1.	Capsaicin	113-122	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	76-80
18063480-10	2008	The average magnitude of the peak inward current evoked by capsaicin was greater in the DRG overexpressing PKD1 than in those expressing DN-PKD1.	Capsaicin	59-68	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	107-111
18063480-10	2008	The average magnitude of the peak inward current evoked by capsaicin was greater in the DRG overexpressing PKD1 than in those expressing DN-PKD1.	Capsaicin	59-68	polycystin 1, transient receptor potential channel interacting	Rattus norvegicus	140-144
18555214-12	2008	Capsaicin treatment significantly modified gastric eNOS/iNOS/COX-2 mRNA expression in cirrhotic rats.	Capsaicin	0-9	nitric oxide synthase 2	Rattus norvegicus	56-60
18555214-12	2008	Capsaicin treatment significantly modified gastric eNOS/iNOS/COX-2 mRNA expression in cirrhotic rats.	Capsaicin	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	61-66
18538749-1	2008	TRPV1, a cation channel on sensory nerves sensitive to heat and capsaicin, plays an important role in the transduction of noxious stimuli to the spinal cord.	Capsaicin	64-73	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
18270244-10	2008	In vagal capsaicin-treated rats subjected to PVS, Fos expression was significantly decreased in both the solitary tract nucleus and paraventricular nucleus compared with untreated PVS rats.	Capsaicin	9-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-53
18519133-0	2008	Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons.	Capsaicin	85-94	carbonic anhydrase 2	Homo sapiens	22-26
18519133-0	2008	Sustained increase of Ca+2 oscillations after chronic TRPV1 receptor activation with capsaicin in cultured spinal neurons.	Capsaicin	85-94	transient receptor potential cation channel subfamily V member 1	Homo sapiens	54-59
18519133-4	2008	The activation of TRPV1 receptors with capsaicin (0.5-1.0 microM) increased the frequency of calcium transients (0.03+/-0.002 Hz vs. 0.05+/-0.006 Hz, P<0.05), mediated by AMPAergic transmission, as well as the percent of neurons with activity (37+/-3% vs. 65+/-4%, P<0.05).	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
18519133-5	2008	The effect of capsaicin was long lasting and the neurons were found to be hyperfunctional and with increased levels of phosphorylated CREB (cAMP responsive element binding) even after 72 h of treatment with capsaicin (32+/-5% vs. 52+/-5%).	Capsaicin	14-23	cAMP responsive element binding protein 1	Homo sapiens	134-138
18519133-5	2008	The effect of capsaicin was long lasting and the neurons were found to be hyperfunctional and with increased levels of phosphorylated CREB (cAMP responsive element binding) even after 72 h of treatment with capsaicin (32+/-5% vs. 52+/-5%).	Capsaicin	14-23	cAMP responsive element binding protein 1	Homo sapiens	140-171
18519133-5	2008	The effect of capsaicin was long lasting and the neurons were found to be hyperfunctional and with increased levels of phosphorylated CREB (cAMP responsive element binding) even after 72 h of treatment with capsaicin (32+/-5% vs. 52+/-5%).	Capsaicin	207-216	cAMP responsive element binding protein 1	Homo sapiens	134-138
18519133-5	2008	The effect of capsaicin was long lasting and the neurons were found to be hyperfunctional and with increased levels of phosphorylated CREB (cAMP responsive element binding) even after 72 h of treatment with capsaicin (32+/-5% vs. 52+/-5%).	Capsaicin	207-216	cAMP responsive element binding protein 1	Homo sapiens	140-171
18519133-6	2008	The effect of capsaicin was blocked by capsazepine (1 microM), TTX (100 nM) and KN-62 (1 microM), but not by K252a (200 nM) or PD98059 (50 microM) indicating the involvement of TRPV1.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	177-182
18519133-7	2008	The results suggest the participation of Ca2+, CaMKII and CREB on the prolonged enhancement of excitability following chronic exposure to capsaicin.	Capsaicin	138-147	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	47-53
18519133-7	2008	The results suggest the participation of Ca2+, CaMKII and CREB on the prolonged enhancement of excitability following chronic exposure to capsaicin.	Capsaicin	138-147	cAMP responsive element binding protein 1	Homo sapiens	58-62
18541272-11	2008	Oral capsaicin significantly increases transient receptor potential vanilloid type-1 (TRPV1) channel expression as well as TRPV1 messenger ribonucleic acid (mRNA) in visceral adipose tissue.	Capsaicin	5-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	39-84
18541272-11	2008	Oral capsaicin significantly increases transient receptor potential vanilloid type-1 (TRPV1) channel expression as well as TRPV1 messenger ribonucleic acid (mRNA) in visceral adipose tissue.	Capsaicin	5-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	86-91
18508045-0	2008	SA13353 (1-[2-(1-Adamantyl)ethyl]-1-pentyl-3-[3-(4-pyridyl)propyl]urea) inhibits TNF-alpha production through the activation of capsaicin-sensitive afferent neurons mediated via transient receptor potential vanilloid 1 in vivo.	Capsaicin	128-137	tumor necrosis factor	Rattus norvegicus	81-90
18508045-6	2008	The ability of SA13353 and capsaicin to inhibit LPS-induced TNF-alpha production was eliminated by sensory denervation or capsazepine pretreatment in vivo.	Capsaicin	27-36	tumor necrosis factor	Rattus norvegicus	60-69
18508045-9	2008	These results suggest that SA13353 inhibits TNF-alpha production through activation of capsaicin-sensitive afferent neurons mediated via TRPV1 in vivo.	Capsaicin	87-96	tumor necrosis factor	Rattus norvegicus	44-53
18508045-9	2008	These results suggest that SA13353 inhibits TNF-alpha production through activation of capsaicin-sensitive afferent neurons mediated via TRPV1 in vivo.	Capsaicin	87-96	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	137-142
17933570-3	2008	Increased excitability of capsaicin sensitive primary afferents (CSPAs), which express TRPV1 receptors, also contributes to central sensitization.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-92
18568077-1	2008	Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel, subfamily V, member 1 (TRPV1) through an unknown mechanism that does not involve TRPV1.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	152-218
18568077-1	2008	Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel, subfamily V, member 1 (TRPV1) through an unknown mechanism that does not involve TRPV1.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	220-225
18568077-1	2008	Cigarette smoke (CS) inhalation causes an early inflammatory response in rodent airways by stimulating capsaicin-sensitive sensory neurons that express transient receptor potential cation channel, subfamily V, member 1 (TRPV1) through an unknown mechanism that does not involve TRPV1.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	278-283
18568077-2	2008	We hypothesized that 2 alpha,beta-unsaturated aldehydes present in CS, crotonaldehyde and acrolein, induce neurogenic inflammation by stimulating TRPA1, an excitatory ion channel coexpressed with TRPV1 on capsaicin-sensitive nociceptors.	Capsaicin	205-214	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	146-151
18450779-9	2008	These results demonstrate that neurotrophins can modulate the excitability of small diameter capsaicin-sensitive sensory neurons through the activation of p75(NTR) and its downstream sphingomyelin signalling cascade.	Capsaicin	93-102	nerve growth factor receptor	Rattus norvegicus	155-163
18419759-7	2008	Accordingly, using in vitro superfusion system of lumbar dorsal root ganglion and spinal cord explants of healthy rats, we show that potassium or capsaicin evoke calcium-dependent release of CCL2.	Capsaicin	146-155	C-C motif chemokine ligand 2	Rattus norvegicus	191-195
18798491-12	2008	CONCLUSION: Pretreatment with capsaicin can attenuate myocardial ischemia-reperfusion injury, of which the likely mechanism is by stimulating capsaicin receptor or TRPV1 and further activating substance P receptor in the rat in vivo.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	142-160
18385449-9	2008	Addition of exogenous PGI(2) or CGRP restored the MNA-induced gastroprotection in rats treated with COX-1 and COX-2 inhibitors or in those with capsaicin denervation.	Capsaicin	144-153	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
18798491-12	2008	CONCLUSION: Pretreatment with capsaicin can attenuate myocardial ischemia-reperfusion injury, of which the likely mechanism is by stimulating capsaicin receptor or TRPV1 and further activating substance P receptor in the rat in vivo.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	164-169
18798491-12	2008	CONCLUSION: Pretreatment with capsaicin can attenuate myocardial ischemia-reperfusion injury, of which the likely mechanism is by stimulating capsaicin receptor or TRPV1 and further activating substance P receptor in the rat in vivo.	Capsaicin	30-39	tachykinin receptor 1	Rattus norvegicus	193-213
18495351-9	2008	In voltage-clamp experiments, 10 nM capsaicin evoked small inward currents in HEK293 cells expressing TRPV1 and ET(A).	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
18495351-9	2008	In voltage-clamp experiments, 10 nM capsaicin evoked small inward currents in HEK293 cells expressing TRPV1 and ET(A).	Capsaicin	36-45	endothelin receptor type A	Homo sapiens	112-117
18495351-10	2008	In the presence of ET-1, capsaicin produced much larger current responses (P<0.05).	Capsaicin	25-34	endothelin 1	Homo sapiens	19-23
18378017-5	2008	Orexin-A-induced protection was abolished by selective OX-1 receptor antagonist, vagotomy and attenuated by suppression of COX-1 and COX-2, deactivation of afferent nerves with neurotoxic dose of capsaicin, pretreatment with CCK(2)/gastrin antagonist, CGRP(8-37) or capsazepine and by inhibition of NOS with L-NNA.	Capsaicin	196-205	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
18423881-8	2008	Selective elimination of unmyelinated C-fibers by neonatal capsaicin treatment resulted in marked reduction of the c-kit receptor and CGRP expression in the superficial layer of the spinal cord.	Capsaicin	59-68	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	115-120
18474376-0	2008	Capsaicin pretreatment attenuates LPS-induced hypothermia through TRPV1-independent mechanisms in chicken.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Gallus gallus	66-71
18474376-8	2008	These findings suggest that a CAP-sensitive TRPV1-independent pathway may be involved in pathophysiological hypothermic reactions through the mediation of NO in chickens.	Capsaicin	30-33	transient receptor potential cation channel subfamily V member 1	Gallus gallus	44-49
18423881-8	2008	Selective elimination of unmyelinated C-fibers by neonatal capsaicin treatment resulted in marked reduction of the c-kit receptor and CGRP expression in the superficial layer of the spinal cord.	Capsaicin	59-68	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	134-138
18423881-9	2008	Cell-size profiles showed that c-kit receptor expression was significantly up-regulated and down-regulated in medium-sized DRG neurons after neonatal capsaicin treatment and nerve injury, respectively.	Capsaicin	150-159	KIT proto-oncogene receptor tyrosine kinase	Mus musculus	31-36
18034335-2	2008	As a result, we found that capsaicin can induce SP release in the absence of extracellular Ca2+ by activating transient receptor potential vanilloid receptor subtype 1 (TRPV1).	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	169-174
18390821-5	2008	In lean pigs, capsaicin, a TRPV1 agonist, relaxed arteries in a dose-dependent manner (EC50 = 116 +/- 41 nM).	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Sus scrofa	27-32
18390821-6	2008	Capsaicin-induced relaxation was blocked by the TRPV1 antagonist capsazepine, endothelial denudation, inhibition of nitric oxide synthase, and K+ channel antagonists.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Sus scrofa	48-53
18390821-12	2008	Impaired capsaicin-induced vasodilation in the metabolic syndrome is associated with decreased expression of TRPV1 and cation influx.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Sus scrofa	109-114
18598259-5	2008	TRPA1-positive afferents in normal animals belonged to the mechanonociceptive populations, many of which also responded to heat or capsaicin but only a few of which responded to cold.	Capsaicin	131-140	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
18598261-1	2008	Patch-clamp techniques and Ca2+ imaging were used to examine the interaction between neurokinins (NK) and the capsaicin(CAPS)-evoked transient receptor potential vanilloid receptor 1 (TRPV1) responses in rat dorsal root ganglia neurons.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	133-182
18598261-1	2008	Patch-clamp techniques and Ca2+ imaging were used to examine the interaction between neurokinins (NK) and the capsaicin(CAPS)-evoked transient receptor potential vanilloid receptor 1 (TRPV1) responses in rat dorsal root ganglia neurons.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	184-189
18467913-1	2008	INTRODUCTION: Chemical stimulation with capsaicin in the intestinal lumen induces abdominal pain, presumably through a mechanism involving the polymodal vanilloid receptor TRPV1 (transient receptor potential vanilloid receptor subtype 1).	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	172-177
18364471-3	2008	Capsaicin (CAP; 0.04, 0.4, and 4 nM), a selective TRPV1 agonist, administered into the renal pelvis dose-dependently increased ARNA.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
18364471-3	2008	Capsaicin (CAP; 0.04, 0.4, and 4 nM), a selective TRPV1 agonist, administered into the renal pelvis dose-dependently increased ARNA.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
18034335-4	2008	In the presence of extracellular Ca2+, a capsaicin-induced maximal release of SP obtained at 100 nM capsaicin was attenuated by either the phosphoinositide 3-kinase (PI3K) inhibitors (wortmannin and LY294002), the inositol 1,4,5-triphosphate (IP3)-induced Ca2+ release blocker (2-aminoethyl diphenylborinate, 2-APB) or a specific antagonist of TRPV1 (capsazepine).	Capsaicin	41-50	arginyl aminopeptidase	Rattus norvegicus	311-314
18034335-4	2008	In the presence of extracellular Ca2+, a capsaicin-induced maximal release of SP obtained at 100 nM capsaicin was attenuated by either the phosphoinositide 3-kinase (PI3K) inhibitors (wortmannin and LY294002), the inositol 1,4,5-triphosphate (IP3)-induced Ca2+ release blocker (2-aminoethyl diphenylborinate, 2-APB) or a specific antagonist of TRPV1 (capsazepine).	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	344-349
18034335-6	2008	In summary, the activation of TRPV1 by capsaicin modulates the SP release from DRG neurons via two different mechanisms, one requiring extracellular Ca2+, the activation of PI3K and the IP3-dependent intracellular Ca2+ release, and the other which is independent of extracellular Ca2+ but involves the activation of MEK.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	30-35
18461159-10	2008	The TRPV1 activation requires residues in transmembrane segments two through four of the voltage-sensor domain, a region previously implicated in capsaicin activation of TRPV1 and analogous menthol activation of TRPM8.	Capsaicin	146-155	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
18331834-2	2008	It was found in this work that a TRPV1 agonist capsaicin, and acidic solution (pH 5.5) induced increases in cytosolic calcium concentration ([Ca(2+)](c)) and reactive oxygen species (ROS) production in synoviocytes isolated from a rat model of collagen-induced arthritis.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	33-38
18405923-3	2008	Treatment of A172 cells with capsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3.	Capsaicin	29-38	BCL2 apoptosis regulator	Homo sapiens	110-115
18405923-3	2008	Treatment of A172 cells with capsaicin inhibited cell growth and induced apoptosis through down-regulation of Bcl-2 and activation of caspase-3.	Capsaicin	29-38	caspase 3	Homo sapiens	134-143
18405923-6	2008	Moreover, capsaicin increased the transcription levels of glial fibrillary acidic protein (GFAP) and neuronal microtubule-associated protein 2ab (MAP2ab).	Capsaicin	10-19	glial fibrillary acidic protein	Homo sapiens	58-89
18405923-6	2008	Moreover, capsaicin increased the transcription levels of glial fibrillary acidic protein (GFAP) and neuronal microtubule-associated protein 2ab (MAP2ab).	Capsaicin	10-19	glial fibrillary acidic protein	Homo sapiens	91-95
18480286-8	2008	These data suggest that mitochondria control vanilloid-induced neurotransmission by translating the strength of presynaptic TRPV1 stimulation into duration of the postsynaptic response.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	124-129
18463260-4	2008	TNFalpha enhanced the expression of the nociceptor-specific heat transducer ion channel transient receptor potential vanilloid 1 (TRPV1) and increased the amplitudes of capsaicin and heat-activated ionic currents via p38/MAP (mitogen-activated protein) kinase and PKC (protein kinase C).	Capsaicin	169-178	tumor necrosis factor	Mus musculus	0-8
18463260-4	2008	TNFalpha enhanced the expression of the nociceptor-specific heat transducer ion channel transient receptor potential vanilloid 1 (TRPV1) and increased the amplitudes of capsaicin and heat-activated ionic currents via p38/MAP (mitogen-activated protein) kinase and PKC (protein kinase C).	Capsaicin	169-178	mitogen-activated protein kinase 14	Mus musculus	217-220
18461159-10	2008	The TRPV1 activation requires residues in transmembrane segments two through four of the voltage-sensor domain, a region previously implicated in capsaicin activation of TRPV1 and analogous menthol activation of TRPM8.	Capsaicin	146-155	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	170-175
18516971-1	2008	Transient receptor potential vanilloid 1 (TRPV1) is a receptor for capsaicin, which is a main ingredient in hot chili peppers, and belongs to the TRP ion channel superfamily.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
18455988-1	2008	Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of noxious heat and capsaicin.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
18455988-1	2008	Transient receptor potential vanilloid 1 (TRPV1) is a molecular sensor of noxious heat and capsaicin.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
18455988-5	2008	Pirt null mice show impaired responsiveness to noxious heat and capsaicin.	Capsaicin	64-73	phosphoinositide-interacting regulator of transient receptor potential channels	Mus musculus	0-4
18455988-6	2008	Noxious heat- and capsaicin-sensitive currents in Pirt-deficient DRG neurons are significantly attenuated.	Capsaicin	18-27	phosphoinositide-interacting regulator of transient receptor potential channels	Mus musculus	50-54
17826200-1	2008	The transient receptor potential vanilloid 1 or TRPV1 is a calcium-permeable ion channel that is activated by capsaicin, the active component of hot chilli peppers, and is involved in the development of inflammatory and neuropathic hyperalgesias.	Capsaicin	110-119	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
18202139-10	2008	The functional link between ghrelin and pain was confirmed by inhibition in vitro of the c-fos response to capsaicin activation of nociceptive fibers, after quantification of Fos-immunoreactive nuclei in laminae IV-VI.	Capsaicin	107-116	ghrelin	Mus musculus	28-35
18202139-10	2008	The functional link between ghrelin and pain was confirmed by inhibition in vitro of the c-fos response to capsaicin activation of nociceptive fibers, after quantification of Fos-immunoreactive nuclei in laminae IV-VI.	Capsaicin	107-116	FBJ osteosarcoma oncogene	Mus musculus	89-94
17826200-4	2008	Calcium responses elicited by the TRPV1 agonist capsaicin were potentiated by treatment with ethanol, but morphine was not able to inhibit ethanol-sensitised capsaicin responses.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
17826200-3	2008	Since the mu opioid receptor (MOP) agonist morphine can inhibit TRPV1 responses potentiated by cAMP-dependent protein kinase A (PKA), and ethanol-mediated modulation of other ion channels involves activation of PKA, we aimed to assess the contribution of MOP-sensitive pathways to the potentiation of TRPV1-mediated capsaicin responses by ethanol.	Capsaicin	316-325	opioid receptor mu 1	Homo sapiens	30-33
17826200-7	2008	However, treatment with wortmannin at concentrations reported to cause PIP2 depletion limited the ability of ethanol to sensitise TRPV1-mediated capsaicin responses.	Capsaicin	145-154	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-135
18230619-1	2008	Transient receptor potential V1 (TRPV1) is a nonselective cation channel expressed in nociceptors and activated by capsaicin.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-31
18398380-1	2008	Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown.	Capsaicin	136-145	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-94
18398380-1	2008	Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown.	Capsaicin	136-145	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
18398380-1	2008	Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown.	Capsaicin	147-150	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-94
18398380-1	2008	Our previous studies show that activation of the transient receptor potential vanilloid type 1 (TRPV1) channels by a selective agonist, capsaicin (CAP), given unilaterally into the renal pelvis leads to increases in urine flow rate (Uflow) and urinary sodium excretion (UNa) bilaterally, although the mechanisms underlying enhanced renal excretory function are unknown.	Capsaicin	147-150	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
18182051-6	2008	Capsaicin (CAP) treatment induced decreased labeling of MitoTracker Red and increased cytosolic cytochrome c and activation of caspase 3 in large neurons isolated from diabetic rats.	Capsaicin	0-9	caspase 3	Rattus norvegicus	127-136
18182051-6	2008	Capsaicin (CAP) treatment induced decreased labeling of MitoTracker Red and increased cytosolic cytochrome c and activation of caspase 3 in large neurons isolated from diabetic rats.	Capsaicin	11-14	caspase 3	Rattus norvegicus	127-136
18182051-7	2008	CAP treatment also induced oxidative stress in large diabetic DRG neurons, which was blocked by pre-treatment with caspase or calpain inhibitor.	Capsaicin	0-3	calpastatin	Rattus norvegicus	126-143
18256211-3	2008	We found that TRPV1 stimulation by capsaicin (intra-arterial administration) of the isolated, perfused right hind limb of the rat increased vascular resistance (by 98 +/- 21 mm Hg at 10 mug) in association with decreased skeletal muscle perfusion and elevation of skin perfusion (detected by dual-channel laser Doppler flowmetry).	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
18391945-1	2008	Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious heat, capsaicin and other diverse stimuli.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-40
18391945-1	2008	Transient receptor potential vanilloid 1 (TRPV1) is an ion channel that is gated by noxious heat, capsaicin and other diverse stimuli.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
18325659-3	2008	Recent evidence shows that TRPV1 receptor stimulation by endocannabinoids or by capsaicin within the periaqueductal grey (PAG) leads to analgesia and this effect is associated with glutamate increase and the activation of OFF cell population in the rostral ventromedial medulla (RVM).	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
18460982-0	2008	Preventive effect of TRPV1 agonists capsaicin and resiniferatoxin on ischemia/reperfusion-induced renal injury in rats.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	21-26
18460982-1	2008	We evaluated the effect of capsaicin, one of the transient receptor potential vanilloid receptor 1 (TRPV1) agonists, on ischemic acute renal failure (ARF) in rats.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-98
18460982-1	2008	We evaluated the effect of capsaicin, one of the transient receptor potential vanilloid receptor 1 (TRPV1) agonists, on ischemic acute renal failure (ARF) in rats.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	100-105
18460982-5	2008	In renal tissues exposed to ischemia/reperfusion, neutrophil infiltration, renal superoxide production, and renal tumor necrosis factor (TNF)-alpha mRNA expression were augmented, but these alterations were attenuated by the treatment with capsaicin.	Capsaicin	240-249	tumor necrosis factor	Rattus norvegicus	114-147
18460982-6	2008	On the other hand, ischemia/reperfusion-enhanced renal interleukin (IL)-10 mRNA expression and plasma concentrations of IL-10 were augmented by treatment with capsaicin in ARF rats.	Capsaicin	159-168	interleukin 10	Rattus norvegicus	120-125
18194153-5	2008	Jejunal strips contracted to the TRPV1 agonist capsaicin.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	33-38
17804099-2	2008	In the present study, Nitroglycerin caused a concentration-dependent relaxation concomitantly with a significant increase in the release of CGRP in the isolated rat thoracic aorta, an effect that was reduced by preincubation with capsaicin.	Capsaicin	230-239	calcitonin-related polypeptide alpha	Rattus norvegicus	140-144
18166234-6	2008	Exogenous CGRP (5 x 10(-9) M) administration of CGRP reappeared postconditioning-like cardioprotection in the rats pretreated with capsaicin.	Capsaicin	131-140	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
18166234-6	2008	Exogenous CGRP (5 x 10(-9) M) administration of CGRP reappeared postconditioning-like cardioprotection in the rats pretreated with capsaicin.	Capsaicin	131-140	calcitonin-related polypeptide alpha	Rattus norvegicus	48-52
18230619-1	2008	Transient receptor potential V1 (TRPV1) is a nonselective cation channel expressed in nociceptors and activated by capsaicin.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-38
18230619-4	2008	In human embryonic kidney 293 cells expressing porcine TRPV1, low [Na(+)](o) evoked increases of [Ca(2+)](i) that were suppressed by TRPV1 antagonists and facilitated responses to capsaicin, protons, heat, and an endovanilloid.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-60
18480552-1	2008	We investigated the presence of EP1 receptor in the urothelium and its role in micturition reflex by examining the effect of intravesical administration of prostaglandin E(2) (PGE2), an EP1 agonist (ONO-DI-004), acetic acid, and capsaicin.	Capsaicin	229-238	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	32-35
18308853-0	2008	Capsaicin-sensitive vagal afferents modulate posttranscriptional regulation of the rat Na+/glucose cotransporter SGLT1.	Capsaicin	0-9	solute carrier family 5 member 1	Rattus norvegicus	113-118
18308853-10	2008	RESULTS: the diurnal rhythm in intestinal SGLT1, with a 5.3-fold increase in Sglt1 mRNA at 4 PM, was preserved in both vagotomy and capsaicin groups.	Capsaicin	132-141	solute carrier family 5 member 1	Rattus norvegicus	42-47
18308853-10	2008	RESULTS: the diurnal rhythm in intestinal SGLT1, with a 5.3-fold increase in Sglt1 mRNA at 4 PM, was preserved in both vagotomy and capsaicin groups.	Capsaicin	132-141	solute carrier family 5 member 1	Rattus norvegicus	77-82
18480552-9	2008	Acetic acid and capsaicin shortened the ICI in both WT mice and EP1-KO mice.	Capsaicin	16-25	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	64-67
18203709-4	2008	Blood flow was measured by laser Doppler flowmetry under anaesthesia and following local application of the TRPV1 agonist capsaicin.	Capsaicin	122-131	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
18327266-3	2008	Application of the TRPV1 ligand capsaicin induced strong inward currents, triggered action potentials and activated stereotyped behaviors, allowing cell type-specific chemical genetic control of neuronal activity in vitro and in vivo.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
18180272-1	2008	On the basis of the ability of capsaicin to activate the transient receptor potential vanilloid 1 receptor (TRPV1) expressed in nociceptive sensory neurons, topical and injectable high-concentration formulations are being developed as potential treatments for various pain syndromes.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	57-106
18180272-1	2008	On the basis of the ability of capsaicin to activate the transient receptor potential vanilloid 1 receptor (TRPV1) expressed in nociceptive sensory neurons, topical and injectable high-concentration formulations are being developed as potential treatments for various pain syndromes.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	108-113
18258298-9	2008	In contrast, LIF prevented the increase in the proportion of heat-sensitive/GAL-IR neurons and the decrease of capsaicin-sensitive/GAL-IR neurons.	Capsaicin	111-120	LIF, interleukin 6 family cytokine	Rattus norvegicus	13-16
18528787-7	2008	Calcium flowing through TRPV1 activates PLC and the resulting depletion of PIP2 was proposed to play a role in capsaicin-induced desensitization of these channels.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
18258298-0	2008	Leukemia inhibitory factor differentially regulates capsaicin and heat sensitivity in cultured rat dorsal root ganglion neurons.	Capsaicin	52-61	LIF, interleukin 6 family cytokine	Rattus norvegicus	0-26
18258298-6	2008	The time course of the proportions of neurons responding to heat (44 degrees C) or capsaicin (1 microM) which also were GAL-IR was differently affected by LIF.	Capsaicin	83-92	LIF, interleukin 6 family cytokine	Rattus norvegicus	155-158
17590514-2	2008	Although several studies in animals and humans have demonstrated that capsaicin (CAP), a TRPV1-specific agonist, and mustard oil (MO), a TRPA1 agonist, evoke responses that undergo functional cross-desensitization in various models, the mechanisms mediating this phenomenon are largely unknown.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
17590514-2	2008	Although several studies in animals and humans have demonstrated that capsaicin (CAP), a TRPV1-specific agonist, and mustard oil (MO), a TRPA1 agonist, evoke responses that undergo functional cross-desensitization in various models, the mechanisms mediating this phenomenon are largely unknown.	Capsaicin	81-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
18272293-3	2008	Very similar results were obtained when stimulating transient receptor potential vanilloid 1 (TRPV1) receptors with capsaicin.	Capsaicin	116-125	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-92
18216286-1	2008	The purpose of this study was to identify the mediators involved in capsaicin-induced vasodilation in the human skin and to evaluate a pharmacodynamic model for the early clinical evaluation of calcitonin gene-related peptide (CGRP) receptor antagonists.	Capsaicin	68-77	calcitonin related polypeptide alpha	Homo sapiens	227-231
18216286-10	2008	CGRP(8-37) inhibited the capsaicin-induced DBF increase: 217(145, 290)% in infused versus 370 (254, 486)% in the noninfused arm [mean (95% CI); p = 0.004].	Capsaicin	25-34	calcitonin related polypeptide alpha	Homo sapiens	0-4
18216286-12	2008	Thus, capsaicin-induced vasodilation in the human forearm skin is largely mediated by CGRP, but not by vasodilating prostaglandins, nitric oxide, or substance P.	Capsaicin	6-15	calcitonin related polypeptide alpha	Homo sapiens	86-90
18272293-3	2008	Very similar results were obtained when stimulating transient receptor potential vanilloid 1 (TRPV1) receptors with capsaicin.	Capsaicin	116-125	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	94-99
18272293-6	2008	In contrast, the intrathecal treatment with TRPA1 antisense oligodeoxynucleotide (2.5 nmol/site) and the degeneration of the subset of primary afferent fibers sensitive to capsaicin significantly reduced allyl isothiocyanate-induced nociception.	Capsaicin	172-181	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	44-49
18272293-10	2008	The selective NK(1) receptor antagonist N(2)-[(4R)-4-hydroxy-1-(1-methyl-1H-indol-3-yl) carbony-1-L-prolyl]-N-methyl-N-phenylmethyl-3-2-(2-naphtyl)-L-alaninamide (10 nmol/paw) reduced either capsaicin- or allyl isothiocyanate-induced nociception.	Capsaicin	191-200	tachykinin receptor 1	Mus musculus	14-28
18272293-11	2008	Collectively, the present findings demonstrate that the TRPA1 agonist allyl isothiocyanate produces a consistent nociceptive response when injected into the mouse paw, an effect that seems to be mediated via activation of TRPA1 receptor and dependent on the capsaicin-sensitive fibers, release of histamine by mast cells and participation of tachykinins.	Capsaicin	258-267	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	56-61
18248905-1	2008	Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation in the innervated area.	Capsaicin	74-83	calcitonin-related polypeptide alpha	Rattus norvegicus	21-52
18222611-3	2008	NMDA alone or when co-administered with D-serine failed to induce NK1r internalization, whereas activation of spinal TRPV1 receptors by capsaicin resulted in a notable NK1r internalization.	Capsaicin	136-145	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	117-122
18222611-3	2008	NMDA alone or when co-administered with D-serine failed to induce NK1r internalization, whereas activation of spinal TRPV1 receptors by capsaicin resulted in a notable NK1r internalization.	Capsaicin	136-145	tachykinin receptor 1	Rattus norvegicus	168-172
18218683-6	2008	Capsaicin-sensitive, but not capsaicin-insensitive, lung-specific neurons responded to cinnamaldehyde, a TRPA1 agonist, with increases in intracellular calcium.	Capsaicin	0-9	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	105-110
18218683-8	2008	Cinnamaldehyde also induced TRPA1-like inward currents (as measured by means of whole cell patch clamp recordings) in capsaicin-sensitive neurons.	Capsaicin	118-127	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	28-33
18242851-5	2008	Capsaicin treatment decreased TRPV1- and CGRP-positive neurons in L4 DRG of the treated side, but not the opposite side.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-35
18242851-5	2008	Capsaicin treatment decreased TRPV1- and CGRP-positive neurons in L4 DRG of the treated side, but not the opposite side.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	41-45
18242851-6	2008	These results suggest that local application of capsaicin onto the sciatic nerve can alleviate mechanical hyperalgesia, but not cold allodynia, in a peripheral neuropathic pain model and the pain alleviation may result from a decrease of TRPV1- and CGRP-positive sensory neurons of which fibers pass through the sciatic nerve.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	238-243
18242851-6	2008	These results suggest that local application of capsaicin onto the sciatic nerve can alleviate mechanical hyperalgesia, but not cold allodynia, in a peripheral neuropathic pain model and the pain alleviation may result from a decrease of TRPV1- and CGRP-positive sensory neurons of which fibers pass through the sciatic nerve.	Capsaicin	48-57	calcitonin related polypeptide alpha	Homo sapiens	249-253
18248905-1	2008	Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation in the innervated area.	Capsaicin	74-83	calcitonin-related polypeptide alpha	Rattus norvegicus	54-58
18178677-4	2008	Our results obtained from perforated whole cell patch-clamp recordings showed that pretreatment with eosinophil major basic protein (MBP; 2 microM, 60 s) significantly increased the capsaicin-evoked inward current in these neurons; this effect peaked approximately 10 min after MBP and lasted for >60 min; in current-clamp mode, MBP substantially increased the number of action potentials evoked by both capsaicin and electrical stimulation.	Capsaicin	407-416	proteoglycan 2	Rattus norvegicus	101-131
18178674-4	2008	In the whole cell perforated patch-clamp study, when the temperature was increased from normal (approximately 36 degrees C) to hyperthermic (approximately 40.6 degrees C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1-3 receptors, were both significantly increased.	Capsaicin	236-245	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	276-321
18178677-4	2008	Our results obtained from perforated whole cell patch-clamp recordings showed that pretreatment with eosinophil major basic protein (MBP; 2 microM, 60 s) significantly increased the capsaicin-evoked inward current in these neurons; this effect peaked approximately 10 min after MBP and lasted for >60 min; in current-clamp mode, MBP substantially increased the number of action potentials evoked by both capsaicin and electrical stimulation.	Capsaicin	407-416	myelin basic protein	Rattus norvegicus	133-136
18178674-4	2008	In the whole cell perforated patch-clamp study, when the temperature was increased from normal (approximately 36 degrees C) to hyperthermic (approximately 40.6 degrees C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1-3 receptors, were both significantly increased.	Capsaicin	236-245	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	323-328
18307678-5	2008	Capsaicin ameliorates urinary bladder symptoms through its stimulatory action on the transient receptor potential vanilloid 1 (TRPV1) calcium channel, resulting in desensitization of bladder sensory nerve terminals.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	85-125
18178674-4	2008	In the whole cell perforated patch-clamp study, when the temperature was increased from normal (approximately 36 degrees C) to hyperthermic (approximately 40.6 degrees C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1-3 receptors, were both significantly increased.	Capsaicin	236-245	arginyl aminopeptidase	Rattus norvegicus	367-370
18178674-4	2008	In the whole cell perforated patch-clamp study, when the temperature was increased from normal (approximately 36 degrees C) to hyperthermic (approximately 40.6 degrees C) level of the rat body temperature, the inward currents evoked by capsaicin, a selective activator of the transient receptor potential vanilloid type 1 (TRPV1), and 2-aminoethoxydiphenyl borate (2-APB), a nonselective activator of TRPV1-3 receptors, were both significantly increased.	Capsaicin	236-245	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	401-406
18178677-4	2008	Our results obtained from perforated whole cell patch-clamp recordings showed that pretreatment with eosinophil major basic protein (MBP; 2 microM, 60 s) significantly increased the capsaicin-evoked inward current in these neurons; this effect peaked approximately 10 min after MBP and lasted for >60 min; in current-clamp mode, MBP substantially increased the number of action potentials evoked by both capsaicin and electrical stimulation.	Capsaicin	182-191	proteoglycan 2	Rattus norvegicus	101-131
18178677-4	2008	Our results obtained from perforated whole cell patch-clamp recordings showed that pretreatment with eosinophil major basic protein (MBP; 2 microM, 60 s) significantly increased the capsaicin-evoked inward current in these neurons; this effect peaked approximately 10 min after MBP and lasted for >60 min; in current-clamp mode, MBP substantially increased the number of action potentials evoked by both capsaicin and electrical stimulation.	Capsaicin	182-191	myelin basic protein	Rattus norvegicus	133-136
18178677-4	2008	Our results obtained from perforated whole cell patch-clamp recordings showed that pretreatment with eosinophil major basic protein (MBP; 2 microM, 60 s) significantly increased the capsaicin-evoked inward current in these neurons; this effect peaked approximately 10 min after MBP and lasted for >60 min; in current-clamp mode, MBP substantially increased the number of action potentials evoked by both capsaicin and electrical stimulation.	Capsaicin	182-191	myelin basic protein	Rattus norvegicus	278-281
18178677-4	2008	Our results obtained from perforated whole cell patch-clamp recordings showed that pretreatment with eosinophil major basic protein (MBP; 2 microM, 60 s) significantly increased the capsaicin-evoked inward current in these neurons; this effect peaked approximately 10 min after MBP and lasted for >60 min; in current-clamp mode, MBP substantially increased the number of action potentials evoked by both capsaicin and electrical stimulation.	Capsaicin	182-191	myelin basic protein	Rattus norvegicus	278-281
18307678-5	2008	Capsaicin ameliorates urinary bladder symptoms through its stimulatory action on the transient receptor potential vanilloid 1 (TRPV1) calcium channel, resulting in desensitization of bladder sensory nerve terminals.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	127-132
18264118-9	2008	SR140333 and capsaicin significantly inhibited the toxin-induced release of TNF-alpha and IL-1beta.	Capsaicin	13-22	tumor necrosis factor	Mus musculus	76-85
18264118-9	2008	SR140333 and capsaicin significantly inhibited the toxin-induced release of TNF-alpha and IL-1beta.	Capsaicin	13-22	interleukin 1 beta	Mus musculus	90-98
18089839-4	2008	Incubation of DRG neurons with STZ resulted in a significant increase in the amplitude of capsaicin-induced TRPV1-mediated current and Ca(2+) influx compared with vehicle-treated sister cultures.	Capsaicin	90-99	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
18079164-5	2008	Uncoupling protein 1 (UCP1) expression and the thermogenic ability in brown adipose tissues were attenuated in the capsaicin-treated rats.	Capsaicin	115-124	uncoupling protein 1	Rattus norvegicus	22-26
18079164-6	2008	These results indicate a critical role of capsaicin-sensitive sensory neurons in both heat and cool sensation and hence in basal thermal homeostasis, which is balanced by heat release and production including UCP1 thermogenesis, following sensation of the ambient temperature.	Capsaicin	42-51	uncoupling protein 1	Rattus norvegicus	209-213
18344609-2	2008	The present study examined the effect of lafutidine on neurotransmission of capsaicin-sensitive calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRPergic nerves) in rat mesenteric resistance arteries.	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	96-127
18344609-2	2008	The present study examined the effect of lafutidine on neurotransmission of capsaicin-sensitive calcitonin gene-related peptide (CGRP)-containing vasodilator nerves (CGRPergic nerves) in rat mesenteric resistance arteries.	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	129-133
18249134-4	2008	Capsaicin-induced [Ca(2+)](i) changes in small diameter DRG neurons were significantly diminished in TRPV1 shRNAtg mice, and administration of capsaicin hardly induced hypothermia or nocifensive behaviour in vivo.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	101-106
18192222-1	2008	Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive C-fiber and Adelta-fiber sensory nerves, has been suggested to play a beneficial role in myocardial ischemia-reperfusion (I/R) injury.	Capsaicin	75-84	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	33-37
18079164-5	2008	Uncoupling protein 1 (UCP1) expression and the thermogenic ability in brown adipose tissues were attenuated in the capsaicin-treated rats.	Capsaicin	115-124	uncoupling protein 1	Rattus norvegicus	0-20
18296611-2	2008	We hypothesized that certain PGE(2) receptor subtypes (EP1-EP4) are co-expressed with TRPV(1) in trigeminal nociceptors and sensitize responses to a TRPV(1) agonist, capsaicin.	Capsaicin	166-175	prostaglandin E receptor 1	Rattus norvegicus	55-62
18296611-2	2008	We hypothesized that certain PGE(2) receptor subtypes (EP1-EP4) are co-expressed with TRPV(1) in trigeminal nociceptors and sensitize responses to a TRPV(1) agonist, capsaicin.	Capsaicin	166-175	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	86-93
18032552-6	2008	Intrapelvic administration of capsaicin or a specific TRPV1 agonist, resiniferatoxin, resulted in a dose-dependent increase in multi-unit ARNA and SP release, and these effects were blocked by the TRVP1 blocker capsazepine.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
18183945-1	2008	Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat.	Capsaicin	113-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-24
18267041-3	2008	The capsaicin and heat receptor TRPV1 is a key molecule in sensory nerves involved in peripheral nociception, but little is known regarding its role in the pregnant uterus.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
18178321-0	2008	Mechanisms of potassium- and capsaicin-induced axonal calcitonin gene-related peptide release: involvement of L- and T-type calcium channels and TRPV1 but not sodium channels.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	145-150
18178321-10	2008	These results suggest that slow depolarization by high extracellular potassium activates axonal low threshold (T-type) as well as high threshold-activated (L-type) voltage-gated calcium channels to mediate iCGRP release, and that capsaicin-induced release is largely dependent on calcium influx through TRPV1.	Capsaicin	230-239	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	303-308
18329285-2	2008	Capsaicin (Cap), a selective TRPV1 agonist, was perfused in the presence or absence of capsazepine (Capz), a selective TRPV1 antagonist, CGRP(8-37), a selective calcitonin gene-related peptide (CGRP) receptor antagonist, or spantide II (Spa), a selective substance P (SP) receptor antagonist.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-34
18031736-8	2008	did not significantly alter food intake in non-deprived rats when measured at 30 min intervals over a period of 24 h. Chemical vagotomy with capsaicin abolished the inhibitory effects of leptin (25 microg/kg, i.p) on food intake in fasted rats and suggest that the hypophagic effect is dependent on intact vagal afferent nerves.	Capsaicin	141-150	leptin	Rattus norvegicus	187-193
18209521-0	2008	Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival?	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	11-16
18079280-9	2008	FTS Ca(2+) responses were inhibited by Omega-conotoxin (70%), hexamethonium (50%), TTX, high Mg(2+)/low Ca(2+) (< or = 100%), or capsaicin (25%).	Capsaicin	132-141	AKT interacting protein	Homo sapiens	0-3
18344596-0	2008	The effect of neonatal capsaicin treatment on the CGRP-immunoreaction in the trigeminal subnucleus caudalis of mice.	Capsaicin	23-32	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	50-54
18344596-2	2008	Although a neonatal administration of capsaicin eliminates substance P (SP)-mediated nociceptive responses to induce a permanent functional reduction in C-fibers, little information is available regarding changes in CGRP-immunoreaction in mice undergoing neonatal capsaicin treatment (CP mice).	Capsaicin	38-47	tachykinin 1	Mus musculus	59-70
18344596-2	2008	Although a neonatal administration of capsaicin eliminates substance P (SP)-mediated nociceptive responses to induce a permanent functional reduction in C-fibers, little information is available regarding changes in CGRP-immunoreaction in mice undergoing neonatal capsaicin treatment (CP mice).	Capsaicin	38-47	tachykinin 1	Mus musculus	72-74
18155908-2	2008	Compound 1 has led to potent TRPV1 antagonistic benzamide derivatives ((+/-)-2: human IC(50)=23 nM, (+/-)-3: human IC(50)=14 nM in the capsaicin-induced calcium influx assay) containing indole and naphthyl moieties, obtained by elaboration of the tryptamine scaffold or via bioisosteric replacements.	Capsaicin	135-144	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
18037908-6	2008	KEY RESULTS: Capsaicin pretreatment significantly increased left ventricular end-diastolic pressure (LVEDP) decreased cardiac NO level, Ca(2+)-dependent NO synthase (NOS) activity, and NOS-3 mRNA.	Capsaicin	13-22	nitric oxide synthase 3	Rattus norvegicus	185-190
18209521-1	2008	OBJECTIVE: In this review, we explain our current understanding of the molecular basis for pain relief by capsaicin and other transient receptor potential vanilloid subfamily, member 1 (TRPV1) agonists.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	186-191
18209521-11	2008	CONCLUSIONS: We argue that TRPV1 agonists and antagonists are not mutually exclusive but rather complimentary pharmacologic approaches for pain relief and we predict a "revival" for capsaicin and other TRPV1 agonists in the clinical management of pain associated with inflammation, metabolic imbalances (eg, diabetes), infections (HIV), and cancer, despite the current focus of the pharmaceutical industry on TRPV1 antagonists.	Capsaicin	182-191	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
17693108-0	2008	Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.	Capsaicin	10-19	insulin-like growth factor 1	Rattus norvegicus	51-79
17693108-5	2008	Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	62-66
18039958-8	2008	MK-0974 produced a concentration-dependent inhibition of dermal vasodilation, generated by capsaicin-induced release of endogenous CGRP, with plasma concentrations of 127 and 994 nM required to block 50 and 90% of the blood flow increase, respectively.	Capsaicin	91-100	calcitonin related polypeptide alpha	Homo sapiens	131-135
17693108-5	2008	Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation.	Capsaicin	18-27	insulin-like growth factor 1	Rattus norvegicus	71-76
17693108-5	2008	Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	222-242
17693108-7	2008	Capsaicin increased both CGRP release and cellular cAMP levels in DRGs isolated from SHR to the levels in DRGs isolated from WKY.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
18218839-6	2008	In contrast, TRPV1 activation is prerequisite for the inhibition of Ca(V)2.3 calcium channels by capsaicin.	Capsaicin	97-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
18218839-6	2008	In contrast, TRPV1 activation is prerequisite for the inhibition of Ca(V)2.3 calcium channels by capsaicin.	Capsaicin	97-106	calcium voltage-gated channel subunit alpha1 E	Homo sapiens	68-76
18240098-0	2008	Adlea (ALGRX-4975), an injectable capsaicin (TRPV1 receptor agonist) formulation for longlasting pain relief.	Capsaicin	34-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-50
18240098-1	2008	Anesiva Inc is developing Adlea (ALRGX-4975) - an injectable preparation of capsaicin, a TRPV1 (transient receptor potential vanilloid subfamily 1) receptor agonist - for the potential management of pain associated with osteoarthritis, tendonitiand postsurgical conditions, as well as for neuropathic pain occurring secondary to nerve injury.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
18172555-6	2008	Lidocaine sensitivity of TRPV1 required segments of the putative vanilloid-binding domain within and adjacent to transmembrane domain 3, was diminished under phosphatidylinositol 4,5-bisphosphate depletion, and was abrogated by a point mutation at residue R701 in the proximal C-terminal TRP domain.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-30
17999197-4	2008	In this paper, we report that adult mice carrying a loss-of-function mutation in the galanin gene (galanin knockout, Gal KO) demonstrate an absence of the normal neurogenic inflammatory response, upon treatment of the skin either with the vanilloid receptor 1 agonist capsaicin or noxious heat.	Capsaicin	268-277	galanin and GMAP prepropeptide	Mus musculus	85-92
17950047-0	2008	Potentiation of pulmonary reflex response to capsaicin 24h following whole-body acrolein exposure is mediated by TRPV1.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	113-118
18093676-7	2008	The induction of c-fos mRNA of CP-treated mice was significantly inhibited by capsaicin pretreatment to deplete C-fibers.	Capsaicin	78-87	FBJ osteosarcoma oncogene	Mus musculus	17-22
18234885-0	2008	Cannabinoids desensitize capsaicin and mustard oil responses in sensory neurons via TRPA1 activation.	Capsaicin	25-34	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	84-89
18234885-9	2008	The knockdown of TRPA1 activity in neurons completely eliminates the desensitizing effects of WIN and AM1241 on capsaicin-activated currents.	Capsaicin	112-121	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	17-22
18234885-10	2008	Furthermore, the WIN- or AM1241-induced inhibition of capsaicin-evoked nocifensive behavior via peripheral actions is reversed in TRPA1 null-mutant mice.	Capsaicin	54-63	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	130-135
18082972-8	2008	SAS neurons also exhibited multiple nociceptor markers such as capsaicin response (38%), action potential (AP) with inflection (35%), or tetrodotoxin resistance (31%).	Capsaicin	63-72	tetraspanin 31	Mus musculus	0-3
18163477-1	2008	OBJECTIVE: Along with their classic afferent function (nociception), capsaicin-sensitive transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve terminals exert local and systemic efferent activities.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	89-129
18037400-4	2008	As a result, 12(S)-HPETE-induced scratching was suppressed by capsaicin (TRPV1 receptor agonist), but not by capsazepine (TRPV1 receptor antagonist).	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
18197100-11	2008	The direct compression of L5 nerve root produced an obvious expression of Fos-like immunoreactivity neurons in the dorsal horn of the spinal cord, which was significantly decreased by pretreatment with capsaicin.	Capsaicin	202-211	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
18065157-8	2008	Nonetheless, the capsaicin-induced CGRP release was also sensitized.	Capsaicin	17-26	calcitonin-related polypeptide alpha	Rattus norvegicus	35-39
18065157-12	2008	Thus, BAM22 sensitizes the capsaicin- and heat-induced CGRP release in an apparently MrgC-unrelated way.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
17997062-8	2008	Capsaicin injection into the TMJ capsule caused an ipsilateral decrease in CGRP levels.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	75-79
18199335-1	2008	Resiniferatoxin (RTX) is an ultrapotent capsaicin analog that binds to the transient receptor potential channel, vanilloid subfamily member 1 (TRPV1).	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-148
17961545-1	2008	Somatostatin released from activated capsaicin-sensitive afferents of the lung inhibits inflammation and related bronchial hyperreactivity presumably via somatostatin 4 receptors (sst(4)).	Capsaicin	37-46	somatostatin receptor 4	Mus musculus	154-178
17961545-1	2008	Somatostatin released from activated capsaicin-sensitive afferents of the lung inhibits inflammation and related bronchial hyperreactivity presumably via somatostatin 4 receptors (sst(4)).	Capsaicin	37-46	somatostatin receptor 4	Mus musculus	180-186
18163477-1	2008	OBJECTIVE: Along with their classic afferent function (nociception), capsaicin-sensitive transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve terminals exert local and systemic efferent activities.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	131-136
19734122-2	2008	Previous reports have revealed that the inhibition of tNOX activity by the anti-cancer drug, capsaicin, correlates with a reduction in growth of cancer cells, indicating a close relationship between tNOX activity and cell growth.	Capsaicin	93-102	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	54-58
19734122-2	2008	Previous reports have revealed that the inhibition of tNOX activity by the anti-cancer drug, capsaicin, correlates with a reduction in growth of cancer cells, indicating a close relationship between tNOX activity and cell growth.	Capsaicin	93-102	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	199-203
19734122-5	2008	The purpose of this study was to investigate the anti-proliferative effect of capsaicin on tNOX expression level in stomach cancer cells.	Capsaicin	78-87	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	91-95
19734122-6	2008	We showed that capsaicin induced cytotoxicity in SCM cells concomitantly with apoptosis, PARP cleavage, and down-regulation of tNOX protein.	Capsaicin	15-24	collagen type XI alpha 2 chain	Homo sapiens	89-93
19734122-6	2008	We showed that capsaicin induced cytotoxicity in SCM cells concomitantly with apoptosis, PARP cleavage, and down-regulation of tNOX protein.	Capsaicin	15-24	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	127-131
18220816-1	2008	Based on the painful effects of exposure to capsaicin, TRPV1 (transient receptor potential vanilloid subfamily member 1) localization is most readily associated with peripheral sensory neurons, however, TRPV1 is now known to be expressed, albeit at lower levels, in the spinal cord, brain and a wide-range of non-neuronal cells.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	55-60
17728277-11	2008	Capsaicin, mustard oil, and cinnamaldehyde may induce heat hyperalgesia via enhanced thermal gating of TRPV1 that is coexpressed with TRPA1 in peripheral nociceptors.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
17728277-11	2008	Capsaicin, mustard oil, and cinnamaldehyde may induce heat hyperalgesia via enhanced thermal gating of TRPV1 that is coexpressed with TRPA1 in peripheral nociceptors.	Capsaicin	0-9	transient receptor potential cation channel subfamily A member 1	Homo sapiens	134-139
19075656-3	2008	Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.	Capsaicin	34-43	insulin-like growth factor 1	Mus musculus	71-76
19075656-3	2008	Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.	Capsaicin	34-43	insulin-like growth factor 1	Mus musculus	81-86
19075656-3	2008	Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.	Capsaicin	34-43	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	124-155
18054007-7	2008	Fifty percent ethanol containing capsaicin immediately increased intragastric levels of CGRP in wild-type (WT) mice, although 50% ethanol alone did not.	Capsaicin	33-42	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	88-92
19075656-3	2008	Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I and IGF-I mRNA in various organs via increased calcitonin gene-related peptide (CGRP) release in mice.	Capsaicin	34-43	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	157-161
19075656-6	2008	Administration of capsaicin and isoflavone increases IGF-I production in hair follicles, thereby promoting hair growth in mice and in volunteers with alopecia.	Capsaicin	18-27	insulin-like growth factor 1	Mus musculus	53-58
19075656-7	2008	Topical application of capsaicin increases dermal levels of IGF-I by stimulating sensory neurons in mice and increases facial skin elasticity in humans.	Capsaicin	23-32	insulin-like growth factor 1	Mus musculus	60-65
19075656-9	2008	Administration of capsaicin increases CGRP and IGF-I levels in plasma, kidneys and the heart in SHR to WKY levels, and normalizes mean arterial blood pressure in SHR.	Capsaicin	18-27	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	38-42
19075656-9	2008	Administration of capsaicin increases CGRP and IGF-I levels in plasma, kidneys and the heart in SHR to WKY levels, and normalizes mean arterial blood pressure in SHR.	Capsaicin	18-27	insulin-like growth factor 1	Mus musculus	47-52
18054007-8	2008	The protective action of capsaicin against ethanol was completely abolished in CGRP(-/-).	Capsaicin	25-34	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	79-83
18481914-0	2008	Calcium-dependent desensitization of vanilloid receptor TRPV1: a mechanism possibly involved in analgesia induced by topical application of capsaicin.	Capsaicin	140-149	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
17499925-0	2008	Activation of the 5-HT1B/D receptor reduces hindlimb neurogenic inflammation caused by sensory nerve stimulation and capsaicin.	Capsaicin	117-126	5-hydroxytryptamine receptor 1B	Rattus norvegicus	18-24
17499925-12	2008	These findings indicate that both local and systemic activation of the 5-HT(1B/D) receptor by sumatriptan reduce NI induced by nerve stimulation or capsaicin presumably by inhibiting neuropeptide release.	Capsaicin	148-157	5-hydroxytryptamine receptor 1B	Rattus norvegicus	71-78
17926096-11	2008	In vivo, TRPV1 agonists such as capsaicin elicit cough when aerosolized and delivered to the lungs.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	9-14
17651868-5	2008	Bath application of 10 microM capsaicin reduced the amplitude of evoked EPSCs both in wild type and TRPV1R knockout animals to a similar extent.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	100-105
17651868-6	2008	Treatment of the slices with the TRPV1R antagonist capsazepine (10 microM) alone, or together with the agonist capsaicin, also caused a decrease in the EPSC amplitude both in wild type and TRPV1R knockout animals.	Capsaicin	111-120	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	189-194
18852901-11	2008	CONCLUSION: TRPV1B expression, together with low TRPV1 expression, may explain the vanilloid paradox: even genuinely TRPV1 mRNA positive cells can be spared with therapeutic (up to micromolar) doses of RTX.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
18481914-3	2008	Depending on the vanilloid concentration and duration of exposure, the Ca2+ influx via TRPV1 desensitizes the channels themselves, which may represent not only a feedback mechanism protecting the cell from toxic Ca2+ overload, but also likely contributes to the analgesic effects of capsaicin.	Capsaicin	17-26	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
18481914-3	2008	Depending on the vanilloid concentration and duration of exposure, the Ca2+ influx via TRPV1 desensitizes the channels themselves, which may represent not only a feedback mechanism protecting the cell from toxic Ca2+ overload, but also likely contributes to the analgesic effects of capsaicin.	Capsaicin	283-292	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
18481914-4	2008	This review summarizes the current state of knowledge concerning the mechanisms that underlie the acute capsaicin-induced Ca2+-dependent desensitization of TRPV1 channels and explores to what extent they may contribute to capsaicin-induced analgesia.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	156-161
17900562-6	2007	Truncal vagotomy, perivagal application of capsaicin and hexamethonium reduced CNP-evoked pancreatic flow and abolished chloride excretion but did not affect protein output.	Capsaicin	43-52	natriuretic peptide C	Rattus norvegicus	79-82
17884737-6	2008	The co-localization of substance P- and CGRP-immunoreactivity was observed in nerve varicosities within ganglia; prolonged exposure to capsaicin in vitro depleted substance P and CGRP immunostaining in nerve varicosities.	Capsaicin	135-144	tachykinin precursor 1	Homo sapiens	23-34
17884737-6	2008	The co-localization of substance P- and CGRP-immunoreactivity was observed in nerve varicosities within ganglia; prolonged exposure to capsaicin in vitro depleted substance P and CGRP immunostaining in nerve varicosities.	Capsaicin	135-144	calcitonin related polypeptide alpha	Homo sapiens	40-44
17884737-6	2008	The co-localization of substance P- and CGRP-immunoreactivity was observed in nerve varicosities within ganglia; prolonged exposure to capsaicin in vitro depleted substance P and CGRP immunostaining in nerve varicosities.	Capsaicin	135-144	tachykinin precursor 1	Homo sapiens	163-174
17884737-6	2008	The co-localization of substance P- and CGRP-immunoreactivity was observed in nerve varicosities within ganglia; prolonged exposure to capsaicin in vitro depleted substance P and CGRP immunostaining in nerve varicosities.	Capsaicin	135-144	calcitonin related polypeptide alpha	Homo sapiens	179-183
17897889-0	2008	Capsaicin-sensitive nerves and neurokinins modulate non-neuronal nNOS expression in lung.	Capsaicin	0-9	nitric oxide synthase, brain	Cavia porcellus	65-69
17897889-1	2008	We investigated the effects of substance P (SP) and neurokinin A (NKA) infusion and acute stimulation of capsaicin-sensitive sensory nerves fibers (CAP) on lung recruitment of neuronal nitric oxide synthase (nNOS)-positive inflammatory and respiratory epithelial (RE) cells in guinea-pigs.	Capsaicin	105-114	nitric oxide synthase, brain	Cavia porcellus	176-206
18055025-4	2008	Interestingly, ablation of TRPV1-positive fibers by subcutaneous capsaicin treatment not only ameliorates pancreatitis pain but also diminishes aging-associated weight gain and improves glucose tolerance both in mice on a high-fat diet and in rat models of type 2 diabetes.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
18055025-7	2008	Ablation of nerves carrying this mutant TRPV1 by capsaicin prevents immune-mediated destruction of islet beta cells despite the persistence of diabetogenic T cells.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-45
17980861-0	2007	Role of soluble guanylate cyclase in the trigeminal subnucleus caudalis in capsaicin-induced muscle hypersensitivity.	Capsaicin	75-84	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	8-33
18154688-0	2007	Inhibition of citric acid- and capsaicin-induced cough by novel TRPV-1 antagonist, V112220, in guinea-pig.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	64-70
17980861-6	2007	We then tested whether intrathecal administration of sGC inhibitors, methylene blue (MB), and ODQ, in the Vc, attenuates masseter hypersensitivity induced by intramuscular injection of capsaicin.	Capsaicin	185-194	guanylate cyclase 1 soluble subunit beta 2	Rattus norvegicus	53-56
17979524-6	2007	Prior exposure of cells to N-acetyl-L -cysteine blocked not only the ROS production but also the nuclear translocation of Nrf2 and its ARE binding, as well as HO-1 induction by capsaicin.	Capsaicin	177-186	heme oxygenase 1	Homo sapiens	159-163
18077685-4	2007	Intra-VL-PAG injection of capsaicin increased the threshold of thermal pain sensitivity, whereas the selective TRPV1 antagonist 5"-iodo-resiniferatoxin (I-RTX) facilitated nociceptive responses, and blocked capsaicin analgesic effect at a dose inactive per se.	Capsaicin	207-216	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	111-116
18077689-6	2007	Pharmacological studies revealed that the activin sensitization of capsaicin responses required PKCepsilon signaling, but not PI3K (phosphoinositide 3-kinase), ERK (extracellular signal-regulated protein kinase), PKA, PKCalpha/beta, or Src.	Capsaicin	67-76	protein kinase C, alpha	Mus musculus	218-231
18077689-6	2007	Pharmacological studies revealed that the activin sensitization of capsaicin responses required PKCepsilon signaling, but not PI3K (phosphoinositide 3-kinase), ERK (extracellular signal-regulated protein kinase), PKA, PKCalpha/beta, or Src.	Capsaicin	67-76	Rous sarcoma oncogene	Mus musculus	236-239
17913835-1	2007	The prototypical member of the vanilloid-responsive-like subfamily of transient receptor potential (TRP) channels is TRPV1.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	117-122
17913835-9	2007	Incorporation of these changes into human TRPV1 gave rise to a channel with a normal EC(50) for capsaicin, but with a markedly elevated Hill slope such that the variant channel was hyporesponsive to capsaicin at low doses (<10 nM) and hyperresponsive at high doses (>10 nM).	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
17913835-9	2007	Incorporation of these changes into human TRPV1 gave rise to a channel with a normal EC(50) for capsaicin, but with a markedly elevated Hill slope such that the variant channel was hyporesponsive to capsaicin at low doses (<10 nM) and hyperresponsive at high doses (>10 nM).	Capsaicin	199-208	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
17825279-7	2007	Likewise, a TRPA1 and TRPM8 agonist icilin, a TRPA1 agonist allicin, and a TRPV1 agonist capsaicin induced contractions in the colon.	Capsaicin	89-98	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	75-80
17979524-0	2007	Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target.	Capsaicin	0-9	heme oxygenase 1	Homo sapiens	18-34
17979524-0	2007	Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target.	Capsaicin	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	79-88
17979524-0	2007	Capsaicin induces heme oxygenase-1 expression in HepG2 cells via activation of PI3K-Nrf2 signaling: NAD(P)H:quinone oxidoreductase as a potential target.	Capsaicin	0-9	crystallin zeta	Homo sapiens	108-130
17979524-3	2007	In the present study, we found that capsaicin induced expression of heme oxygenase-1 (HO-1) in HepG2 cells.	Capsaicin	36-45	heme oxygenase 1	Homo sapiens	68-84
17979524-7	2007	Immunoblot analysis showed that whereas the level of HO-1 protein was elevated, that of NAD(P)H:quinone oxidoreductase (NQO1) was decreased after the treatment with capsaicin or the inhibitor of NQO1, dicumarol.	Capsaicin	165-174	heme oxygenase 1	Homo sapiens	53-57
17979524-3	2007	In the present study, we found that capsaicin induced expression of heme oxygenase-1 (HO-1) in HepG2 cells.	Capsaicin	36-45	heme oxygenase 1	Homo sapiens	86-90
17979524-4	2007	Capsaicin treatment resulted in a transient increase in the phosphorylation of Akt and subsequently nuclear translocation of NF-E2-related factor 2 (Nrf2), enhancing its binding to antioxidant response element (ARE).	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	79-82
17979524-7	2007	Immunoblot analysis showed that whereas the level of HO-1 protein was elevated, that of NAD(P)H:quinone oxidoreductase (NQO1) was decreased after the treatment with capsaicin or the inhibitor of NQO1, dicumarol.	Capsaicin	165-174	crystallin zeta	Homo sapiens	96-118
17979524-4	2007	Capsaicin treatment resulted in a transient increase in the phosphorylation of Akt and subsequently nuclear translocation of NF-E2-related factor 2 (Nrf2), enhancing its binding to antioxidant response element (ARE).	Capsaicin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	125-147
17979524-7	2007	Immunoblot analysis showed that whereas the level of HO-1 protein was elevated, that of NAD(P)H:quinone oxidoreductase (NQO1) was decreased after the treatment with capsaicin or the inhibitor of NQO1, dicumarol.	Capsaicin	165-174	NAD(P)H quinone dehydrogenase 1	Homo sapiens	120-124
17979524-4	2007	Capsaicin treatment resulted in a transient increase in the phosphorylation of Akt and subsequently nuclear translocation of NF-E2-related factor 2 (Nrf2), enhancing its binding to antioxidant response element (ARE).	Capsaicin	0-9	NFE2 like bZIP transcription factor 2	Homo sapiens	149-153
17979524-7	2007	Immunoblot analysis showed that whereas the level of HO-1 protein was elevated, that of NAD(P)H:quinone oxidoreductase (NQO1) was decreased after the treatment with capsaicin or the inhibitor of NQO1, dicumarol.	Capsaicin	165-174	NAD(P)H quinone dehydrogenase 1	Homo sapiens	195-199
17979524-8	2007	We hypothesize that quinone metabolites or other reactive forms of capsaicin may bind covalently to NQO1 and thereby inhibit its activity, leading to production of ROS.	Capsaicin	67-76	NAD(P)H quinone dehydrogenase 1	Homo sapiens	100-104
17906682-1	2007	BACKGROUND AND PURPOSE: Calcitonin gene-related peptide (CGRP), a capsaicin-sensitive neuromodulator of splanchnic vascular tone in several animal species, remains poorly investigated in mouse models.	Capsaicin	66-75	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	24-55
17906682-1	2007	BACKGROUND AND PURPOSE: Calcitonin gene-related peptide (CGRP), a capsaicin-sensitive neuromodulator of splanchnic vascular tone in several animal species, remains poorly investigated in mouse models.	Capsaicin	66-75	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	57-61
17928338-5	2007	Surprisingly, RV binding and infection are absent in about half of the p75(NTR)-expressing DRG neurons which have small diameters and are often capsaicin sensitive.	Capsaicin	144-153	PC4 and SFRS1 interacting protein 1	Homo sapiens	71-74
17984664-5	2007	Capsaicin, a selective TRPV1 receptor agonist, or CGRP dose-dependently decreased MAP in normal or high-sodium-treated rats, with a greater effect in the latter.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	23-28
18042138-0	2007	Modulation of intracellular calcium influences capsaicin-induced currents of TRPV-1 and voltage-activated channel currents in nociceptive neurones.	Capsaicin	47-56	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-83
18042138-4	2007	The TRPV-1 receptor was activated by the application of 0.5 microM capsaicin, and the currents through TRPV-1 and VACC [I(TRPV-1) and I(Ca(V))] were measured either when Ca2+ release from intracellular stores was pharmacologically promoted or prevented.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-10
18042138-5	2007	With Ba2+ as the divalent charge carrier, capsaicin (0.5 microM) reduced I(Ca(V)) (elicited by a depolarization to 0 mV) to 52.7 +/- 4.5% of baseline, and the elicited current through the TRPV-1 receptor/channel complex was 6.6 +/- 0.9% [relative to peak I(Ca(V))].	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	188-194
18042138-7	2007	Increases of [Ca2+](i) by releasing Ca2+ from intracellular stores (using caffeine, 10 mM) before the application of capsaicin increased the I(TRPV-1) (14.1 +/- 7%), while the I(Ca(V)) was decreased to 51.6 +/- 4.9% compared with control.	Capsaicin	117-126	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-149
18159132-6	2007	Collectively, the mechanism accounting for the capsaicin-induced increase in the intestinal cefazolin absorption is probably that capsaicin associating with TRPV1 increases the intrinsic permeability of cefazolin in intestine.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	157-162
18159132-6	2007	Collectively, the mechanism accounting for the capsaicin-induced increase in the intestinal cefazolin absorption is probably that capsaicin associating with TRPV1 increases the intrinsic permeability of cefazolin in intestine.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	157-162
17508360-5	2007	Capsaicin (CAP) (1-10 microM) increased nonselective cation channel whole cell currents (2.5-fold +/- 0.5-fold between -60 and 130 mV), resulting in calcium transients that were fully blocked by the TRPV1 antagonists capsazepine (CPZ) and ruthenium red, or removal of extracellular calcium.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
17508360-5	2007	Capsaicin (CAP) (1-10 microM) increased nonselective cation channel whole cell currents (2.5-fold +/- 0.5-fold between -60 and 130 mV), resulting in calcium transients that were fully blocked by the TRPV1 antagonists capsazepine (CPZ) and ruthenium red, or removal of extracellular calcium.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
18091582-1	2007	Calcitonin gene-related peptide (CGRP), the predominant neurotransmitter in capsaicin-sensitive sensory nerves, is a potent vasodilator and inhibits proliferation of vascular smooth muscle cells.	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
18091582-1	2007	Calcitonin gene-related peptide (CGRP), the predominant neurotransmitter in capsaicin-sensitive sensory nerves, is a potent vasodilator and inhibits proliferation of vascular smooth muscle cells.	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
17928338-5	2007	Surprisingly, RV binding and infection are absent in about half of the p75(NTR)-expressing DRG neurons which have small diameters and are often capsaicin sensitive.	Capsaicin	144-153	neurotensin receptor 1	Homo sapiens	75-78
18032651-2	2007	TRPV1, a pain receptor involved in nociception at the peripheral nerve terminals, can be activated by a range of physical and chemical stimuli (e.g., capsaicin, proton, and heat) and further sensitized by proinflammatory substances.	Capsaicin	150-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
17920775-2	2007	In the rat, activation of capsaicin-sensitive nociceptors, which express the transient receptor potential vanilloid type 1 (TRPV1) receptor, induces meningeal vasodilatation, a significant component of neurogenic inflammation, through the release of calcitonin gene-related peptide (CGRP).	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	77-122
17920775-2	2007	In the rat, activation of capsaicin-sensitive nociceptors, which express the transient receptor potential vanilloid type 1 (TRPV1) receptor, induces meningeal vasodilatation, a significant component of neurogenic inflammation, through the release of calcitonin gene-related peptide (CGRP).	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	124-129
17920775-2	2007	In the rat, activation of capsaicin-sensitive nociceptors, which express the transient receptor potential vanilloid type 1 (TRPV1) receptor, induces meningeal vasodilatation, a significant component of neurogenic inflammation, through the release of calcitonin gene-related peptide (CGRP).	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	250-281
17920775-2	2007	In the rat, activation of capsaicin-sensitive nociceptors, which express the transient receptor potential vanilloid type 1 (TRPV1) receptor, induces meningeal vasodilatation, a significant component of neurogenic inflammation, through the release of calcitonin gene-related peptide (CGRP).	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	283-287
17920775-8	2007	In diabetic rats, a significant decrease in the capsaicin-evoked release of CGRP and reduction in the density of TRPV1-immunoreactive (IR) nerves were demonstrated.	Capsaicin	48-57	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
17920775-9	2007	Treatment of the diabetic rats with insulin restored both the vasodilatory response and the capsaicin-induced CGRP release toward control values.	Capsaicin	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	110-114
17920775-10	2007	In conclusion, this study revealed a marked impairment of meningeal TRPV1-IR nerves in streptozotocin diabetic rats by showing reduced neurogenic sensory vasodilatation, decreased capsaicin-evoked CGRP release and reduction in the number of TRPV1-IR nerve fibers of the dura mater.	Capsaicin	180-189	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-73
17920775-10	2007	In conclusion, this study revealed a marked impairment of meningeal TRPV1-IR nerves in streptozotocin diabetic rats by showing reduced neurogenic sensory vasodilatation, decreased capsaicin-evoked CGRP release and reduction in the number of TRPV1-IR nerve fibers of the dura mater.	Capsaicin	180-189	calcitonin-related polypeptide alpha	Rattus norvegicus	197-201
17948977-7	2007	These models are consistent with the proposed binding modes and interactions of known activators of the TRPV1 channel such as capsaicin, in a structural model of the TM3/4 helical region of TRPV1.	Capsaicin	126-135	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-109
17948977-7	2007	These models are consistent with the proposed binding modes and interactions of known activators of the TRPV1 channel such as capsaicin, in a structural model of the TM3/4 helical region of TRPV1.	Capsaicin	126-135	transient receptor potential cation channel subfamily V member 1	Homo sapiens	190-195
17828286-10	2007	CONCLUSIONS AND IMPLICATIONS: THC inhibits the EFS-induced release of CGRP (and subsequent vasorelaxation), from capsaicin-sensitive sensory nerves in the rat perfused mesentery.	Capsaicin	113-122	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74
18001466-2	2007	TRPV1, the heat-, pH- and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released in response to noxious stimuli and during inflammation, is a potential target for the action of ET-1.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
18001466-2	2007	TRPV1, the heat-, pH- and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released in response to noxious stimuli and during inflammation, is a potential target for the action of ET-1.	Capsaicin	26-35	endothelin 1	Homo sapiens	230-234
18001466-6	2007	ET-1 strongly potentiated capsaicin-induced TRPV1 currents in some neurons, and in HEK293 cells co-expressing TRPV1 and the ETAR.	Capsaicin	26-35	endothelin 1	Homo sapiens	0-4
18001466-6	2007	ET-1 strongly potentiated capsaicin-induced TRPV1 currents in some neurons, and in HEK293 cells co-expressing TRPV1 and the ETAR.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-49
18001466-6	2007	ET-1 strongly potentiated capsaicin-induced TRPV1 currents in some neurons, and in HEK293 cells co-expressing TRPV1 and the ETAR.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
18001466-6	2007	ET-1 strongly potentiated capsaicin-induced TRPV1 currents in some neurons, and in HEK293 cells co-expressing TRPV1 and the ETAR.	Capsaicin	26-35	endothelin receptor type A	Homo sapiens	124-128
17828457-7	2007	Pharmacological inhibition of JNK kinase, as well as inhibition of ROS by the reducing agent N-acetylcysteine, prevented ceramide accumulation and capsaicin-induced cell death.	Capsaicin	147-156	mitogen-activated protein kinase 8	Homo sapiens	30-33
17828457-10	2007	Capsaicin-promoted activation of ERK was prevented with all the inhibitors tested.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	33-36
17828457-11	2007	We conclude that capsaicin induces apoptosis in PC-3 cells via ROS generation, JNK activation, ceramide accumulation, and second, ERK activation.	Capsaicin	17-26	mitogen-activated protein kinase 8	Homo sapiens	79-82
17828457-11	2007	We conclude that capsaicin induces apoptosis in PC-3 cells via ROS generation, JNK activation, ceramide accumulation, and second, ERK activation.	Capsaicin	17-26	mitogen-activated protein kinase 1	Homo sapiens	130-133
17851073-2	2007	The analogs were evaluated for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells.	Capsaicin	54-63	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	99-104
17828457-0	2007	Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation.	Capsaicin	21-30	sphingomyelin phosphodiesterase 2	Homo sapiens	86-110
17828457-0	2007	Apoptosis induced by capsaicin in prostate PC-3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation.	Capsaicin	21-30	mitogen-activated protein kinase 8	Homo sapiens	116-119
17828457-5	2007	Using siRNA, we demonstrated that N-SMase expression is required for the effect of capsaicin on prostate cell viability.	Capsaicin	83-92	sphingomyelin phosphodiesterase 2	Homo sapiens	34-41
17761445-0	2007	Involvement of a capsaicin-sensitive TRPV1-independent mechanism in lipopolysaccharide-induced fever in chickens.	Capsaicin	17-26	transient receptor potential cation channel subfamily V member 1	Gallus gallus	37-42
17761445-8	2007	These findings suggest that a capsaicin-sensitive TRPV1-independent mechanism may be involved in LPS-induced fever.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Gallus gallus	50-55
17690251-3	2007	The affinity of JNJ17203212 for the recombinant guinea pig TRPV1 receptor was estimated by radioligand binding, and it was functionally characterized by antagonism of low-pH and capsaicin-induced activation of the ion channel (fluorometric imaging plate reader and electrophysiology).	Capsaicin	178-187	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	59-64
18052948-10	2007	In addition, KCl, capsaicin, and a nitric oxide donor also caused a significant increase in CGRP release.	Capsaicin	18-27	calcitonin related polypeptide alpha	Homo sapiens	92-96
18052948-11	2007	Interestingly, CO(2) treatment of cultures under isohydric conditions, which prevents extracellular acidification while allowing changes in PCO(2) values, significantly repressed the stimulatory effects of KCl, capsaicin, and nitric oxide on CGRP secretion.	Capsaicin	211-220	calcitonin related polypeptide alpha	Homo sapiens	242-246
17986814-6	2007	Both partially purified DRG neurons and non-neuronal cells exhibited a weaker substance P release response to capsaicin or KCl, relative to unpurified DRG cells.	Capsaicin	110-119	tachykinin precursor 1	Homo sapiens	78-89
18224287-8	2007	CONCLUSIONS: The TRPV1 receptor-independent potentiating action of PMA on contralateral acetone-induced ear oedema is mediated via capsaicin-sensitive afferents and prostanoids are involved.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	17-22
17462749-5	2007	Bilateral vagotomy as well as capsaicin deactivation of sensory fibers completely abolished all stimulatory effects of luminal ghrelin on pancreatic exocrine function.	Capsaicin	30-39	ghrelin and obestatin prepropeptide	Rattus norvegicus	127-134
17961222-0	2007	Roles of TRPV1 and neuropeptidergic receptors in dorsal root reflex-mediated neurogenic inflammation induced by intradermal injection of capsaicin.	Capsaicin	137-146	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-14
17961222-1	2007	BACKGROUND: Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs).	Capsaicin	173-182	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-119
17961222-1	2007	BACKGROUND: Acute cutaneous neurogenic inflammation initiated by activation of transient receptor potential vanilloid-1 (TRPV1) receptors following intradermal injection of capsaicin is mediated mainly by dorsal root reflexes (DRRs).	Capsaicin	173-182	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	121-126
17961222-4	2007	RESULTS: Here we used pharmacological manipulations to analyze the roles of TRPV1 and neuropeptidergic receptors in the DRR-mediated neurogenic inflammation induced by intradermal injection of capsaicin.	Capsaicin	193-202	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	76-81
17961222-9	2007	Dose-response analysis of the antagonistic effect of the TRPV1 receptor antagonist, capsazepine administered peripherally, shows that the capsaicin-evoked inflammation was inhibited in a dose-dependent manner, and nearly completely abolished by capsazepine at doses between 30-150 mug.	Capsaicin	138-147	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
17961222-11	2007	If both CGRP and NK1 receptors were blocked by co-administration of CGRP8-37 and spantide I, a stronger reduction in the capsaicin-initiated inflammation was produced.	Capsaicin	121-130	calcitonin-related polypeptide alpha	Rattus norvegicus	8-12
17961222-12	2007	CONCLUSION: Our data suggest that 1) the generation of DRRs is critical for driving the release of neuropeptides antidromically from primary afferent nociceptors; 2) activation of TRPV1 receptors in primary afferent nociceptors following intradermal capsaicin injection initiates this process; 3) the released CGRP and SP participate in neurogenic inflammation.	Capsaicin	250-259	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	180-185
17656446-0	2007	Increased visceral sensitivity to capsaicin after DSS-induced colitis in mice: spinal cord c-Fos expression and behavior.	Capsaicin	34-43	FBJ osteosarcoma oncogene	Mus musculus	91-96
17914397-5	2007	QX-314 applied externally had no effect on the activity of sodium channels in small sensory neurons when applied alone, but when applied in the presence of the TRPV1 agonist capsaicin, QX-314 blocked sodium channels and inhibited excitability.	Capsaicin	174-183	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	160-165
17914397-6	2007	Inhibition by co-applied QX-314 and capsaicin was restricted to neurons expressing TRPV1.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
17656446-11	2007	Moreover, capsaicin-induced spinal cord neuronal c-Fos expression was significantly increased.	Capsaicin	10-19	FBJ osteosarcoma oncogene	Mus musculus	49-54
18162454-1	2007	Antidromic stimulation of the rat trigeminal ganglion triggers the release of substance P (SP) and calcitonin gene-related peptide (CGRP) from sensory nerve terminals of the capsaicin sensitive C-fibers.	Capsaicin	174-183	calcitonin-related polypeptide alpha	Rattus norvegicus	99-130
17700720-9	2007	In low NGF, exposure to the CB receptor agonist, WIN55 (1 microM) reduces capsaicin-mediated increases in [Ca(2+)](i) to 28+/-8% of control as compared to an enhancement to 172+/-26% of control observed in high NGF.	Capsaicin	74-83	nerve growth factor	Homo sapiens	211-214
18162454-1	2007	Antidromic stimulation of the rat trigeminal ganglion triggers the release of substance P (SP) and calcitonin gene-related peptide (CGRP) from sensory nerve terminals of the capsaicin sensitive C-fibers.	Capsaicin	174-183	calcitonin-related polypeptide alpha	Rattus norvegicus	132-136
17569567-0	2007	Administration of capsaicin and isoflavone promotes hair growth by increasing insulin-like growth factor-I production in mice and in humans with alopecia.	Capsaicin	18-27	insulin-like growth factor 1	Mus musculus	78-106
17569567-9	2007	Dermal levels of IGF-I were significantly higher in WT mice administered capsaicin and isoflavone for 4 wks than in those administered capsaicin alone for 4 wks (p < 0.01) and in those administered neither of them (p < 0.01).	Capsaicin	135-144	insulin-like growth factor 1	Mus musculus	17-22
17569567-2	2007	Capsaicin activates vanilloid receptor-1, thereby increasing the release of calcitonin gene-related peptide (CGRP) from sensory neurons, and CGRP has been shown to increase IGF-I production.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-40
17569567-2	2007	Capsaicin activates vanilloid receptor-1, thereby increasing the release of calcitonin gene-related peptide (CGRP) from sensory neurons, and CGRP has been shown to increase IGF-I production.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	76-107
17569567-10	2007	Immunohistochemical expression of IGF-I at dermal papillae in hair follicles was increased in WT mice administered capsaicin and isoflavone and in those administered capsaicin alone at 4 wks.	Capsaicin	115-124	insulin-like growth factor 1	Mus musculus	34-39
17569567-10	2007	Immunohistochemical expression of IGF-I at dermal papillae in hair follicles was increased in WT mice administered capsaicin and isoflavone and in those administered capsaicin alone at 4 wks.	Capsaicin	166-175	insulin-like growth factor 1	Mus musculus	34-39
17569567-2	2007	Capsaicin activates vanilloid receptor-1, thereby increasing the release of calcitonin gene-related peptide (CGRP) from sensory neurons, and CGRP has been shown to increase IGF-I production.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	109-113
17569567-12	2007	Plasma levels of IGF-I were significantly increased from baseline levels in 31 volunteers with alopecia at 5 months after oral administration of capsaicin (6 mg/day) and isoflavone (75 mg/day) (p < 0.01), while they were not increased in 17 volunteers with alopecia administered placebo.	Capsaicin	145-154	insulin-like growth factor 1	Mus musculus	17-22
17569567-14	2007	CONCLUSIONS: These observations strongly suggested that combined administration of capsaicin and isoflavone might increase IGF-I production in hair follicles in the skin, thereby promoting hair growth.	Capsaicin	83-92	insulin-like growth factor 1	Mus musculus	123-128
17569567-4	2007	These observations raise the possibility that administration of capsaicin and isoflavone might promote hair growth by increasing IGF-I production.	Capsaicin	64-73	insulin-like growth factor 1	Mus musculus	129-134
17569567-8	2007	RESULTS: Subcutaneous administration of capsaicin significantly increased dermal IGF-I levels at 30 min after administration in WT mice (p < 0.01), but not in CGRP-knockout mice.	Capsaicin	40-49	insulin-like growth factor 1	Mus musculus	81-86
17569567-9	2007	Dermal levels of IGF-I were significantly higher in WT mice administered capsaicin and isoflavone for 4 wks than in those administered capsaicin alone for 4 wks (p < 0.01) and in those administered neither of them (p < 0.01).	Capsaicin	73-82	insulin-like growth factor 1	Mus musculus	17-22
17760719-11	2007	We confirmed that capsaicin inhibited IL-8 mRNA expression after infection of gastric epithelial cells with H. pylori for 6 hours.	Capsaicin	18-27	C-X-C motif chemokine ligand 8	Homo sapiens	38-42
17760719-3	2007	Herein, we demonstrated that capsaicin inhibited the release of pro-inflammatory cytokine, interleukin-8 (IL-8) by H. pylori-infected gastric epithelial cells through nuclear factor-kappaB (NF-kappaB) signal pathway.	Capsaicin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	106-110
17760719-6	2007	We measured IL-8 mRNA transcripts in H. pylori-infected gastric epithelial cells co-treated with capsaicin by reverse transcriptase-polymerase chain reaction analysis.	Capsaicin	97-106	C-X-C motif chemokine ligand 8	Homo sapiens	12-16
17760719-14	2007	CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways.	Capsaicin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	68-72
17760719-9	2007	RESULTS: Capsaicin inhibits H. pylori-induced IL-8 production by gastric epithelial cells in dose- and time-dependent manner.	Capsaicin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	46-50
17760719-10	2007	Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control).	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	59-63
17760719-10	2007	Capsaicin as low as 100 micromol/L significantly inhibited IL-8 production in H. pylori-infected MKN45 cells (43.2% of control) at 24 hours incubation, whereas inhibited IL-8 production in H. pylori-infected AGS cells (70% of control).	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	170-174
17760719-14	2007	CONCLUSIONS: Nontoxic dose of capsaicin inhibited H. pylori-induced IL-8 production by gastric epithelial cells through the modulation of IkappaB-, NF-kappaB-, and IL-8 pathways.	Capsaicin	30-39	C-X-C motif chemokine ligand 8	Homo sapiens	164-168
17760719-15	2007	We conclude that capsaicin can be proposed as a potential anti-inflammatory drug by inhibition of the production of IL-8 in H. pylori-infected gastric epithelium.	Capsaicin	17-26	C-X-C motif chemokine ligand 8	Homo sapiens	116-120
17508023-7	2007	Furthermore, direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased MMP-1 expression.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
17393331-1	2007	Dietary capsaicin reduces rodent visceral fat weight.	Capsaicin	8-17	FAT atypical cadherin 1	Rattus norvegicus	42-45
17508023-7	2007	Furthermore, direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased MMP-1 expression.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
17508023-7	2007	Furthermore, direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased MMP-1 expression.	Capsaicin	43-52	matrix metallopeptidase 1	Homo sapiens	81-86
17652633-1	2007	Capsaicin, the active ingredient in some pain-relieving creams, is an agonist of a nonselective cation channel known as the transient receptor potential vanilloid type 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	124-169
17652633-1	2007	Capsaicin, the active ingredient in some pain-relieving creams, is an agonist of a nonselective cation channel known as the transient receptor potential vanilloid type 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	171-176
17652633-2	2007	The pain-relieving mechanism of capsaicin includes desensitization of the channel, suggesting that TRPV1 antagonism may be a viable pain therapy approach.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
17652633-5	2007	Both AMG 517 and AMG8163 potently and completely antagonized capsaicin, proton, and heat activation of TRPV1 in vitro and blocked capsaicin-induced flinch in rats in vivo.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-108
17719033-3	2007	Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.	Capsaicin	0-9	mast cell protease 1	Mus musculus	48-53
17850966-3	2007	The use of capsaicin for TRPV1 is an exemplary case for nociceptor studies.	Capsaicin	11-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-30
17719033-3	2007	Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.	Capsaicin	0-9	interleukin 6	Mus musculus	39-43
17719033-3	2007	Capsaicin inhibited the expressions of IL-6 and MCP-1 mRNAs and protein release from the adipose tissues and adipocytes of obese mice, whereas it enhanced the expression of the adiponectin gene and protein.	Capsaicin	0-9	adiponectin, C1Q and collagen domain containing	Mus musculus	177-188
17719033-4	2007	The action of capsaicin is associated with NF-kappaB inactivation and/or PPARgamma activation.	Capsaicin	14-23	peroxisome proliferator activated receptor gamma	Mus musculus	73-82
17616464-4	2007	Three compounds showed partial TRPV1 agonism with EC(50) values in the low micromolar range and maximal efficacies between 25% and 55% of capsaicin.	Capsaicin	138-147	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
17629487-2	2007	alpha-Methyl substituted analogues showed potent and stereospecific antagonism to the action of capsaicin on rat TRPV1 heterologously expressed in Chinese hamster ovary cells.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	113-118
17586490-1	2007	The contractile responses to capsaicin and anandamide, exogenous and endogenous agonists for transient receptor potential vanilloid receptor 1 (TRPV1), respectively, were investigated in muscle strips isolated from the rat urinary bladder.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-149
17586490-11	2007	These results indicate that capsaicin produces muscle contractions by stimulating the TRPV1 receptor, followed by release of neuropeptides that can activate tachykinin NK(1) and/or NK(2) receptors in the bladder and that the contractile response to anandamide is mediated at least in part by activation of prostanoid EP(1) receptors due to production of prostaglandins in addition to TRPV1 receptor activation.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	86-91
17586490-11	2007	These results indicate that capsaicin produces muscle contractions by stimulating the TRPV1 receptor, followed by release of neuropeptides that can activate tachykinin NK(1) and/or NK(2) receptors in the bladder and that the contractile response to anandamide is mediated at least in part by activation of prostanoid EP(1) receptors due to production of prostaglandins in addition to TRPV1 receptor activation.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	384-389
17623652-8	2007	Trypsin IV and p23 increased [Ca(2+)](i) in rat dorsal root ganglion neurons that responded to capsaicin and which thus mediate neurogenic inflammation and nociception.	Capsaicin	95-104	preprotrypsinogen IV	Rattus norvegicus	0-10
17586490-7	2007	The response to capsaicin was abolished in the presence of a TRPV1 antagonist, N-(4-tertiarybutylphenyl)-4-(3-chlorphyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC), but not altered in the presence of either tetrodotoxin, atropine or indomethacin.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
17623652-8	2007	Trypsin IV and p23 increased [Ca(2+)](i) in rat dorsal root ganglion neurons that responded to capsaicin and which thus mediate neurogenic inflammation and nociception.	Capsaicin	95-104	cyclin-dependent kinase 5 regulatory subunit 1	Rattus norvegicus	15-18
17586490-8	2007	In the presence of SR140333, a tachykinin NK(1) receptor antagonist or SR48968, an NK(2) receptor antagonist, the response to capsaicin was attenuated.	Capsaicin	126-135	tachykinin receptor 2	Rattus norvegicus	83-97
17662046-3	2007	Here we show that pafr-/- mice displayed almost normal responses to thermal and mechanical stimuli but exhibit attenuated persistent pain behaviors resulting from tissue injury by locally injecting formalin at the periphery as well as capsaicin pain and visceral inflammatory pain without any alteration in cytoarchitectural or neurochemical properties in dorsal root ganglion (DRG) neurons and a defect in motor function.	Capsaicin	235-244	platelet-activating factor receptor	Mus musculus	18-22
17681724-8	2007	In capsaicin model, the antinociception produced by 200 mg/kg red sap was found to be naloxone-sensitive (2 mg/kg, i.p.	Capsaicin	3-12	SH2 domain containing 1A	Mus musculus	66-69
17627983-9	2007	Afferent responses to distension were significantly attenuated in TRPV1-/- mice in which sensitivity to intravesical hydrochloric acid (50 mm) and capsaicin (10 microm) were also blunted.	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	66-71
17874046-6	2007	At day 7, the sensory denervation induced by neonatal capsaicin administration inhibited pancreatic inflammation on both histological (determination of interstitial edema, expansion of interlobular septa and intercellular spaces, and inflammatory cell infiltration) and biochemical (intrapancreatic myeloperoxidase activity) evaluation.	Capsaicin	54-63	myeloperoxidase	Rattus norvegicus	299-314
17662046-5	2007	A PAFR agonist evoked an intracellular Ca(2+) response predominantly in capsaicin-sensitive DRG neurons, an effect was not observed in pafr-/- mice.	Capsaicin	72-81	platelet-activating factor receptor	Mus musculus	2-6
17698245-2	2007	In this study we measured PACAP-like immunoreactivity with radioimmunoassay in the rat plasma and showed a two-fold elevation in response to systemic stimulation of capsaicin-sensitive sensory nerves by resiniferatoxin, but not after local excitation of cutaneous afferents.	Capsaicin	165-174	adenylate cyclase activating polypeptide 1	Rattus norvegicus	26-31
18069241-2	2007	Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively].	Capsaicin	33-42	acetylcholinesterase (Cartwright blood group)	Homo sapiens	95-99
18069241-2	2007	Among the alkaloids tested, only capsaicin exerted a remarkable inhibitory effect towards both AChE and BChE [(62.7 +/- 0.79)% and (75.3 +/- 0.98)%, respectively].	Capsaicin	33-42	butyrylcholinesterase	Homo sapiens	104-108
17698245-3	2007	Neurogenic plasma extravasation in the plantar skin induced by intraplantar capsaicin or resiniferatoxin, as well as carrageenan-induced paw edema were significantly diminished by intraperitoneal PACAP-38.	Capsaicin	76-85	adenylate cyclase activating polypeptide 1	Rattus norvegicus	196-201
17698245-4	2007	In summary, these results demonstrate that PACAP is released from activated capsaicin-sensitive afferents into the systemic circulation.	Capsaicin	76-85	adenylate cyclase activating polypeptide 1	Rattus norvegicus	43-48
17584831-3	2007	Here we show that TRPA1 is desensitized by homologous (mustard oil; a TRPA1 agonist) and heterologous (capsaicin; a TRPV1 agonist) agonists via Ca2+-independent and Ca2+-dependent pathways, respectively, in sensory neurons.	Capsaicin	103-112	transient receptor potential cation channel subfamily A member 1	Homo sapiens	18-23
17683869-11	2007	TRPA1 agonist allyl isothiocyanate (mustard oil) 50-100 microM and TRPV1 agonist capsaicin 1-3 microM had no effect.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-72
17640568-7	2007	EtOH, capsaicin, and SP stimulated generation of ROS by superficial gastric epithelial cells expressing neurokinin 1 receptors by a neurokinin 1 receptor-dependent mechanism.	Capsaicin	6-15	tachykinin 1	Mus musculus	104-116
17640568-7	2007	EtOH, capsaicin, and SP stimulated generation of ROS by superficial gastric epithelial cells expressing neurokinin 1 receptors by a neurokinin 1 receptor-dependent mechanism.	Capsaicin	6-15	tachykinin 1	Mus musculus	132-144
17666428-3	2007	Ca(2+)-dependent CGRP release was evoked with K(+)-depolarisation and, to lower levels, by capsaicin or bradykinin from neurons that contain the vanilloid receptor 1 and/or bradykinin receptor 2.	Capsaicin	91-100	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
17584831-3	2007	Here we show that TRPA1 is desensitized by homologous (mustard oil; a TRPA1 agonist) and heterologous (capsaicin; a TRPV1 agonist) agonists via Ca2+-independent and Ca2+-dependent pathways, respectively, in sensory neurons.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-121
17666428-3	2007	Ca(2+)-dependent CGRP release was evoked with K(+)-depolarisation and, to lower levels, by capsaicin or bradykinin from neurons that contain the vanilloid receptor 1 and/or bradykinin receptor 2.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	145-165
17584831-4	2007	The pharmacological desensitization of TRPA1 by capsaicin and mustard oil is not influenced by activation of protein phosphatase 2B.	Capsaicin	48-57	transient receptor potential cation channel subfamily A member 1	Homo sapiens	39-44
17442041-0	2007	Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	59-64
17632091-1	2007	Two different mechanisms by which capsaicin blocks voltage-gated sodium channels (VGSCs) were found by using knockout mice for the transient receptor potential V1 (TRPV1(-/-)).	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	164-169
17632091-2	2007	Similar with cultured rat trigeminal ganglion (TG) neurons, the amplitude of tetrodotoxin-resistant (TTX-R) sodium current was reduced 85% by 1 muM capsaicin in capsaicin sensitive neurons, while only 6% was blocked in capsaicin insensitive neurons of TRPV1(+/+) mice.	Capsaicin	148-157	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	252-257
17632091-3	2007	The selective effect of low concentration capsaicin on VGSCs was reversed in TRPV1(-/-) mice, which suggested that this effect was dependent on TRPV1 receptor.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	77-82
17632091-3	2007	The selective effect of low concentration capsaicin on VGSCs was reversed in TRPV1(-/-) mice, which suggested that this effect was dependent on TRPV1 receptor.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	144-149
17632091-4	2007	The blockage effect of high concentration capsaicin on VGSCs in TRPV1(-/-) mice was the same as that in capsaicin insensitive neurons of rats and TRPV1(+/+) mice.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	64-69
17560936-6	2007	Stimulation of cultured OA- and RA-SF with the TRPV1 agonist capsaicin led to increased expression of IL-6 mRNA as well as of IL-6 protein in the cell culture supernatants.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
17560936-6	2007	Stimulation of cultured OA- and RA-SF with the TRPV1 agonist capsaicin led to increased expression of IL-6 mRNA as well as of IL-6 protein in the cell culture supernatants.	Capsaicin	61-70	interleukin 6	Homo sapiens	102-106
17560936-6	2007	Stimulation of cultured OA- and RA-SF with the TRPV1 agonist capsaicin led to increased expression of IL-6 mRNA as well as of IL-6 protein in the cell culture supernatants.	Capsaicin	61-70	interleukin 6	Homo sapiens	126-130
17640294-2	2007	A significant and consistent increase in CGRP secretion was elicited by non-specific (56 mm KCl or veratridine) or specific (capsaicin) depolarizing stimuli.	Capsaicin	125-134	calcitonin-related polypeptide alpha	Rattus norvegicus	41-45
17640294-6	2007	Such effects of NOC were seemingly mediated by the activation of specific ORL1 receptors, as a well-known nociceptin antagonist, N(Phe1)nociceptin (1-13)NH2, was able to completely revert NOC inhibition of capsaicin-stimulated CGRP release.	Capsaicin	206-215	opioid related nociceptin receptor 1	Rattus norvegicus	74-78
17640294-6	2007	Such effects of NOC were seemingly mediated by the activation of specific ORL1 receptors, as a well-known nociceptin antagonist, N(Phe1)nociceptin (1-13)NH2, was able to completely revert NOC inhibition of capsaicin-stimulated CGRP release.	Capsaicin	206-215	prepronociceptin	Rattus norvegicus	106-116
17640294-6	2007	Such effects of NOC were seemingly mediated by the activation of specific ORL1 receptors, as a well-known nociceptin antagonist, N(Phe1)nociceptin (1-13)NH2, was able to completely revert NOC inhibition of capsaicin-stimulated CGRP release.	Capsaicin	206-215	prepronociceptin	Rattus norvegicus	136-146
17581853-14	2007	These effects of anandamide differ from those of the classical exogenous TRPV1-agonist capsaicin and suggest a primarily modulatory mode of action of anandamide.	Capsaicin	87-96	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	73-78
17588562-2	2007	In the present study, the role of capsaicin-sensitive sensory neurons in contraction induced by activation of PAR-2 was investigated in the rat urinary bladders.	Capsaicin	34-43	F2R like trypsin receptor 1	Rattus norvegicus	110-115
17588562-3	2007	The contractile responses to trypsin and the PAR-2 agonist 2-furoyl-LIGRL-NH(2) were significantly attenuated by either desensitization of sensory neurons achieved by capsaicin (10 microM) or by the TRPV1 antagonist capsazepine (30 microM).	Capsaicin	167-176	F2R like trypsin receptor 1	Rattus norvegicus	45-50
17588562-4	2007	These results suggest that stimulation of capsaicin-sensitive sensory fibers contributes, at least in part, to PAR-2-mediated bladder contractions in rats.	Capsaicin	42-51	F2R like trypsin receptor 1	Rattus norvegicus	111-116
17628541-1	2007	Several lines of evidence indicate that phosphatidylinositol 3-kinase (PI3K) and PI3K-protein kinase B/Akt (PKB/Akt) signal pathway mediate the pain hypersensitivity induced by intradermal injection of capsaicin or nerve growth factor.	Capsaicin	202-211	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	40-69
17628541-1	2007	Several lines of evidence indicate that phosphatidylinositol 3-kinase (PI3K) and PI3K-protein kinase B/Akt (PKB/Akt) signal pathway mediate the pain hypersensitivity induced by intradermal injection of capsaicin or nerve growth factor.	Capsaicin	202-211	AKT serine/threonine kinase 1	Rattus norvegicus	103-106
17628541-1	2007	Several lines of evidence indicate that phosphatidylinositol 3-kinase (PI3K) and PI3K-protein kinase B/Akt (PKB/Akt) signal pathway mediate the pain hypersensitivity induced by intradermal injection of capsaicin or nerve growth factor.	Capsaicin	202-211	AKT serine/threonine kinase 1	Rattus norvegicus	108-111
17628541-1	2007	Several lines of evidence indicate that phosphatidylinositol 3-kinase (PI3K) and PI3K-protein kinase B/Akt (PKB/Akt) signal pathway mediate the pain hypersensitivity induced by intradermal injection of capsaicin or nerve growth factor.	Capsaicin	202-211	AKT serine/threonine kinase 1	Rattus norvegicus	112-115
17442052-6	2007	Capsaicin, anandamide, resiniferatoxin and olvanil mediated increases in [Ca(2+)](i) were inhibited by the TRPV1 antagonists capsazepine and iodo-resiniferatoxin with potencies (K(B)) of approximately 70 nmol/L and 2 nmol/L, respectively.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
17442052-7	2007	Capsaicin stimulated the release of pre-labelled [(3)H]noradrenaline from monolayers of SH-SY5Y(hTRPV1) cells with an EC(50) of 0.6 nmol/L indicating amplification between [Ca(2+)](i) and release.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-102
17442041-0	2007	Capsaicin-induced apoptosis of glioma cells is mediated by TRPV1 vanilloid receptor and requires p38 MAPK activation.	Capsaicin	0-9	mitogen-activated protein kinase 14	Homo sapiens	97-100
17442041-1	2007	We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-90
17442041-1	2007	We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-97
17442041-1	2007	We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis.	Capsaicin	150-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-90
17670969-5	2007	In the spinal cord, these compounds abolished the enhanced capsaicin-evoked calcitonin gene-related peptide (CGRP) release and dynorphin A upregulation, both elicited by nerve injury.	Capsaicin	59-68	calcitonin-related polypeptide alpha	Rattus norvegicus	76-107
17670969-5	2007	In the spinal cord, these compounds abolished the enhanced capsaicin-evoked calcitonin gene-related peptide (CGRP) release and dynorphin A upregulation, both elicited by nerve injury.	Capsaicin	59-68	calcitonin-related polypeptide alpha	Rattus norvegicus	109-113
17442041-1	2007	We provide evidence on the expression of the transient receptor potential vanilloid type-1 (TRPV1) by glioma cells, and its involvement in capsaicin (CPS)-induced apoptosis.	Capsaicin	150-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-97
17442041-7	2007	CPS-induced apoptosis involved Ca(2+) influx, p38 but not extracellular signal-regulated mitogen-activated protein kinase activation, phosphatidylserine exposure, mitochondrial permeability transmembrane pore opening and mitochondrial transmembrane potential dissipation, caspase 3 activation and oligonucleosomal DNA fragmentation.	Capsaicin	0-3	mitogen-activated protein kinase 14	Homo sapiens	46-49
17442041-7	2007	CPS-induced apoptosis involved Ca(2+) influx, p38 but not extracellular signal-regulated mitogen-activated protein kinase activation, phosphatidylserine exposure, mitochondrial permeability transmembrane pore opening and mitochondrial transmembrane potential dissipation, caspase 3 activation and oligonucleosomal DNA fragmentation.	Capsaicin	0-3	caspase 3	Homo sapiens	272-281
17442041-9	2007	Finally, p38 but not extracellular signal-regulated protein kinase activation was required for TRPV1-mediated CPS-induced apoptosis of glioma cells.	Capsaicin	110-113	mitogen-activated protein kinase 14	Homo sapiens	9-12
17442041-9	2007	Finally, p38 but not extracellular signal-regulated protein kinase activation was required for TRPV1-mediated CPS-induced apoptosis of glioma cells.	Capsaicin	110-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
17521627-1	2007	Exposure of the anterior hepatic plexus to 2% perineurial capsaicin solution over three days caused transient insulin resistance confirmed by hyperinsulinaemic euglycaemic glucose clamping.	Capsaicin	58-67	insulin	Oryctolagus cuniculus	110-117
17459370-0	2007	Role of cyclin-dependent kinase 5 in capsaicin-induced cough.	Capsaicin	37-46	cyclin-dependent kinase 5	Mus musculus	8-33
17379411-4	2007	In addition, the NMUR2 mutant mice showed a reduced behavioral response and a marked reduction in thermal hyperalgesia following capsaicin injection.	Capsaicin	129-138	neuromedin U receptor 2	Mus musculus	17-22
17583335-3	2007	These compounds are potent antagonists of capsaicin activation of the TRPV1 receptor in vitro.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
17585749-8	2007	In addition, compound 74 was shown to be efficacious at blocking a TRPV1-mediated physiological response in vivo in the capsaicin-induced hypothermia model in rats; however, it was ineffective at preventing thermal hyperalgesia induced by complete Freund"s adjuvant in rats.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-72
17585750-2	2007	A series of novel 4-oxopyrimidine TRPV1 antagonists was evaluated in assays measuring the blockade of capsaicin or acid-induced influx of calcium into CHO cells expressing TRPV1.	Capsaicin	102-111	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	34-39
17507218-2	2007	Alkylated compounds showed weaker in vitro potencies in blocking capsaicin activation of TRPV1 receptor, but possessed improved pharmacokinetic properties.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
17459370-1	2007	The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice.	Capsaicin	52-61	cyclin-dependent kinase 5	Mus musculus	12-37
17459370-1	2007	The role of cyclin-dependent kinase 5 (Cdk5) in the capsaicin-induced cough reflex was examined in mice.	Capsaicin	52-61	cyclin-dependent kinase 5	Mus musculus	39-43
17459370-2	2007	Pretreatment with inhaled roscovitine, a selective Cdk5 inhibitor, at concentrations of 0.3 to 3 mM inhibited the number of capsaicin-induced coughs in a concentration-dependent manner.	Capsaicin	124-133	cyclin-dependent kinase 5	Mus musculus	51-55
17596195-1	2007	Heat-activated ion channels from the vanilloid-type TRP group (TRPV1-4) seem to be central for heat-sensitivity of nociceptive sensory neurons.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	63-70
17184838-0	2007	A novel function of capsaicin-sensitive TRPV1 channels: involvement in cell migration.	Capsaicin	20-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
17184838-4	2007	We show here that the capsaicin-sensitive transient receptor potential channel TRPV1, that plays an important role in pain transduction, is one of the Ca2+ influx channels involved in cell migration.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	79-84
17184838-5	2007	Activating TRPV1 channels with capsaicin leads to an acceleration of human hepatoblastoma (HepG2) cells pretreated with hepatocyte growth factor (HGF).	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	11-16
17184838-5	2007	Activating TRPV1 channels with capsaicin leads to an acceleration of human hepatoblastoma (HepG2) cells pretreated with hepatocyte growth factor (HGF).	Capsaicin	31-40	hepatocyte growth factor	Homo sapiens	120-144
17184838-5	2007	Activating TRPV1 channels with capsaicin leads to an acceleration of human hepatoblastoma (HepG2) cells pretreated with hepatocyte growth factor (HGF).	Capsaicin	31-40	hepatocyte growth factor	Homo sapiens	146-149
17184838-9	2007	The TRPV1 antagonist capsazepine prevents the stimulation of migration and inhibits capsaicin-sensitive currents.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
17184838-10	2007	Finally, we compared the contribution of capsaicin-sensitive TRPV1 channels to cell migration with that of mechanosensitive TRPV4 channels that are also expressed in HepG2 cells.	Capsaicin	41-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
17184838-12	2007	In summary, we assigned a novel role to capsaicin-sensitive TRPV1 channels.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-65
17596195-5	2007	In the present study, we demonstrate that the features of heterologously expressed rat TRPV2 closely resemble those of high-threshold heat-evoked currents in medium- and large-sized capsaicin-insensitive rat dorsal root ganglion (DRG) neurons.	Capsaicin	182-191	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	87-92
17635592-10	2007	CGRP levels in the ganglion were measured by radioimmunoassay in response to capsaicin.	Capsaicin	77-86	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
17635592-18	2007	Decreased CGRP levels in the ganglion were observed 2 hours following capsaicin stimulation.	Capsaicin	70-79	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
17543465-1	2007	Several lines of evidence suggest that extracellular ATP plays a role in pain signaling through the activation of ionotropic P2X-receptors, especially homomeric P2X3- and heteromeric P2X2/3-receptors on capsaicin-sensitive and -insensitive primary afferent neurons, respectively, at peripheral and spinal sites.	Capsaicin	203-212	purinergic receptor P2X 3	Rattus norvegicus	161-165
17687396-1	2007	OBJECTIVE: To investigate the regulatory effects of nerve growth factor (NGF) on basal and capsaicin-induced release of neuropeptide substance P (SP) in primary cultured embryonic rat dorsal root ganglion (DRG) neurons.	Capsaicin	91-100	nerve growth factor	Rattus norvegicus	52-71
17687396-1	2007	OBJECTIVE: To investigate the regulatory effects of nerve growth factor (NGF) on basal and capsaicin-induced release of neuropeptide substance P (SP) in primary cultured embryonic rat dorsal root ganglion (DRG) neurons.	Capsaicin	91-100	nerve growth factor	Rattus norvegicus	73-76
17687396-7	2007	Both basal release and capsaicin-evoked release of SP increased in NGF-treated DRG neurons compared with in control group.	Capsaicin	23-32	nerve growth factor	Rattus norvegicus	67-70
17687396-8	2007	The capsaicin-evoked release of SP also increased in a dose-dependent manner of NGF.	Capsaicin	4-13	nerve growth factor	Rattus norvegicus	80-83
17687396-9	2007	CONCLUSION: NGF may promote both basal release and capsaicin-evoked release of SP.	Capsaicin	51-60	nerve growth factor	Rattus norvegicus	12-15
17603282-4	2007	We also found that the number of erythropoietin receptor (EpoR)-positive cells was increased by capsaicin.	Capsaicin	96-105	erythropoietin receptor	Mus musculus	33-56
17603282-4	2007	We also found that the number of erythropoietin receptor (EpoR)-positive cells was increased by capsaicin.	Capsaicin	96-105	erythropoietin receptor	Mus musculus	58-62
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	erythropoietin receptor	Mus musculus	120-124
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	glycophorin A	Mus musculus	126-139
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	glycophorin A	Mus musculus	141-144
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	hemoglobin, beta adult major chain	Mus musculus	160-166
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	GATA binding protein 1	Mus musculus	169-175
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	spleen focus forming virus (SFFV) proviral integration oncogene	Mus musculus	177-181
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	nuclear factor, erythroid derived 2	Mus musculus	183-217
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	nuclear factor, erythroid derived 2	Mus musculus	219-224
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	Kruppel-like factor 1 (erythroid)	Mus musculus	231-252
17603282-6	2007	Quantitative RT-PCR analysis revealed that capsaicin stimulated the expression of the erythroid-specific genes encoding EpoR, glycophorin A (GPA), beta-globin (Hbb-b1), GATA-1, PU.1, nuclear factor erythroid-derived 2 (NF-E2), and Kruppel-like factor 1 (KLF1) in the BFU-E colonies.	Capsaicin	43-52	Kruppel-like factor 1 (erythroid)	Mus musculus	254-258
17603282-7	2007	Furthermore, capsaicin could effectively stimulate the transfected GATA-1 promoter in K562 cells.	Capsaicin	13-22	GATA binding protein 1	Homo sapiens	67-73
17603899-5	2007	Intrathecal (IT) injection of the NKCC1 inhibitor bumetanide (BUM, 1 nmol) inhibited referred, abdominal allodynia evoked by an intracolonic capsaicin injection.	Capsaicin	141-150	solute carrier family 12, member 2	Mus musculus	34-39
17579717-2	2007	Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit Ca(2+)-uptake via the vanilloid inducible Ca(2+)-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca(2+) entry.	Capsaicin	112-121	calmodulin 1	Rattus norvegicus	46-56
17596456-4	2007	TRPV1 currents undergo desensitization on exposure to high concentrations of capsaicin in the presence of extracellular Ca2+.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
17596456-5	2007	We show that in the presence of extracellular Ca2+, capsaicin activates phospholipase C (PLC) in TRPV1-expressing cells, inducing depletion of both PtdIns(4,5)P2 and its precursor PtdIns(4)P (PIP).	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
17596456-5	2007	We show that in the presence of extracellular Ca2+, capsaicin activates phospholipase C (PLC) in TRPV1-expressing cells, inducing depletion of both PtdIns(4,5)P2 and its precursor PtdIns(4)P (PIP).	Capsaicin	52-61	prolactin induced protein	Homo sapiens	192-195
17582331-1	2007	TRPV1 plays a key role in nociception, as it is activated by heat, low pH, and ligands such as capsaicin, leading to a burning pain sensation.	Capsaicin	95-104	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
17579717-2	2007	Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit Ca(2+)-uptake via the vanilloid inducible Ca(2+)-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca(2+) entry.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	176-181
17579717-2	2007	Paradoxically, classical anti-psychotic, anti-calmodulin drugs were noted here to inhibit Ca(2+)-uptake via the vanilloid inducible Ca(2+)-channel/inflamatory pain receptor 1 (TRPV1), which suggests that calmodulin inhibitors may block pore formation and Ca(2+) entry.	Capsaicin	112-121	calmodulin 1	Rattus norvegicus	204-214
17579717-3	2007	Functional assays on TRPV1 expressing cells support direct, dose-dependent inhibition of vanilloid-induced (45)Ca(2+)-uptake at microM concentrations: calmidazolium (broad range) > or = trifluoperazine (narrow range) chlorpromazine/amitriptyline>fluphenazine>>W-7 and W-13 (only partially).	Capsaicin	89-98	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	21-26
17579717-5	2007	Camstatin, a selective peptide blocker of calmodulin, inhibits vanilloid-induced Ca(2+)-uptake in intact TRPV1(+) cells, and suggests an extracellular site of inhibition.	Capsaicin	63-72	calmodulin 1	Rattus norvegicus	42-52
17579717-5	2007	Camstatin, a selective peptide blocker of calmodulin, inhibits vanilloid-induced Ca(2+)-uptake in intact TRPV1(+) cells, and suggests an extracellular site of inhibition.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	105-110
17291600-1	2007	Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive afferents induce neurogenic inflammation via NK(1), NK(2) and CGRP1 receptor activation.	Capsaicin	74-83	tachykinin 1	Mus musculus	0-16
17291600-1	2007	Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive afferents induce neurogenic inflammation via NK(1), NK(2) and CGRP1 receptor activation.	Capsaicin	74-83	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	21-52
17291600-1	2007	Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive afferents induce neurogenic inflammation via NK(1), NK(2) and CGRP1 receptor activation.	Capsaicin	74-83	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	54-58
17291600-1	2007	Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive afferents induce neurogenic inflammation via NK(1), NK(2) and CGRP1 receptor activation.	Capsaicin	74-83	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	156-161
17525595-6	2007	Selective knockdown of CGRP in primary afferents significantly attenuated the thermal, C-fiber hyperalgesia normally observed after topical application of capsaicin.	Capsaicin	155-164	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	23-27
17369424-1	2007	The transient receptor potential vanilloid 1 (TRPV1) channel is a nonselective cation channel activated by capsaicin and responsible for thermosensation.	Capsaicin	107-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-44
17369424-1	2007	The transient receptor potential vanilloid 1 (TRPV1) channel is a nonselective cation channel activated by capsaicin and responsible for thermosensation.	Capsaicin	107-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
17379752-7	2007	When pH levels in the infused solution were 7.4, 6.5, 5.5, and 4.5, capsaicin (1 microg/kg), a TRPV1 agonist, was injected into the artery.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	95-100
17610576-1	2007	We have previously shown that isolated rat sciatic nerve axons express capsaicin, heat and proton sensitivity and respond to stimulation with a Ca(++)-dependent and graded calcitonin gene related peptide (CGRP) release.	Capsaicin	71-80	calcitonin-related polypeptide alpha	Rattus norvegicus	205-209
17392405-0	2007	Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.	Capsaicin	116-125	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-79
17339608-5	2007	Moreover, the vanilloid capsaicin, a full agonist of transient receptor potential channel VR1, did not affect [Ca(2+)](i)levels in the RBL-2H3 cells, thus excluding the involvement of this receptor in the CBD-mediated effects.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	90-93
17363391-6	2007	Capsaicin potently increased the frequency but not the amplitude of mEPSCs in a calcium-dependent manner, suggesting TRPV1-mediated glutamate release from presynaptic terminals of sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	117-122
17392405-0	2007	Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.	Capsaicin	116-125	transient receptor potential cation channel subfamily V member 1	Homo sapiens	80-85
17392405-1	2007	Vanilloid receptor-1 (TRPV1) is a nonselective cation channel, predominantly expressed by sensory neurons, which plays a key role in the detection of noxious painful stimuli such as capsaicin, acid, and heat.	Capsaicin	182-191	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
17392405-4	2007	Using a Ca(2+)-based fluorometric imaging plate reader (FLIPR) assay, SB-705498 was shown to be a potent competitive antagonist of the capsaicin-mediated activation of the human TRPV1 receptor (pK(i) = 7.6) with activity at rat (pK(i) = 7.5) and guinea pig (pK(i) = 7.3) orthologs.	Capsaicin	135-144	transient receptor potential cation channel subfamily V member 1	Homo sapiens	178-183
17237150-1	2007	Airways are densely innervated by capsaicin-sensitive sensory neurons expressing transient receptor potential vanilloid 1 (TRPV1) receptors/ion channels, which play an important regulatory role in inflammatory processes via the release of sensory neuropeptides.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	81-121
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	194-203	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-48
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	194-203	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	194-203	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-92
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	194-203	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-97
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	205-208	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-48
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	205-208	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	205-208	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-92
17917113-1	2007	Transient receptor potential vanilloid subtype 1 (TRPV1), also known as vanilloid receptor 1 (VR1), is a nonselective cation channel that is activated by a variety of ligands, such as exogenous capsaicin (CAP) or endogenous anandamide (AEA), as well as products of lipoxygenases.	Capsaicin	205-208	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-97
17274957-0	2007	Capsaicin causes protein synthesis inhibition and microtubule disassembly through TRPV1 activities both on the plasma membrane and intracellular membranes.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
17274957-1	2007	TRPV1 is a non-selective cationic channel that is activated by capsaicin, acidic pH and thermal stimuli.	Capsaicin	63-72	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
17274957-3	2007	In this study, we investigated the mechanisms of capsaicin-induced cytotoxicity in HEK293 cells stably expressing TRPV1 with a focus on protein synthesis regulation and cytoskeleton reorganization.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	114-119
17274957-4	2007	Capsaicin inhibited protein synthesis in TRPV1-expressing HEK cells with an IC(50) of 15.6nM and depolymerized microtubules within 10min after exposure.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
17274957-6	2007	Protein synthesis inhibition induced by capsaicin was not a result of eIF2alpha hyperphosphorylation, but rather closely correlated with cytosolic calcium elevation caused by calcium flux through cell surface and intracellular TRPV1, and/or ER calcium depletion through intracellular TRPV1.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	284-289
17505005-0	2007	Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.	Capsaicin	0-9	interleukin 6	Homo sapiens	49-62
17505005-0	2007	Capsaicin is a novel blocker of constitutive and interleukin-6-inducible STAT3 activation.	Capsaicin	0-9	signal transducer and activator of transcription 3	Homo sapiens	73-78
17505005-3	2007	EXPERIMENTAL DESIGN: The effect of capsaicin on both constitutive and interleukin-6-induced STAT3 activation, associated protein kinases, and STAT3-regulated gene products involved in proliferation, survival and angiogenesis, cellular proliferation, and apoptosis in multiple myeloma cells was investigated.	Capsaicin	35-44	interleukin 6	Homo sapiens	70-83
17505005-3	2007	EXPERIMENTAL DESIGN: The effect of capsaicin on both constitutive and interleukin-6-induced STAT3 activation, associated protein kinases, and STAT3-regulated gene products involved in proliferation, survival and angiogenesis, cellular proliferation, and apoptosis in multiple myeloma cells was investigated.	Capsaicin	35-44	signal transducer and activator of transcription 3	Homo sapiens	92-97
17505005-3	2007	EXPERIMENTAL DESIGN: The effect of capsaicin on both constitutive and interleukin-6-induced STAT3 activation, associated protein kinases, and STAT3-regulated gene products involved in proliferation, survival and angiogenesis, cellular proliferation, and apoptosis in multiple myeloma cells was investigated.	Capsaicin	35-44	signal transducer and activator of transcription 3	Homo sapiens	142-147
17505005-4	2007	RESULTS: We found that capsaicin inhibited constitutive activation of STAT3 in multiple myeloma cells in a dose- and time-dependent manner, with minimum effect on STAT5.	Capsaicin	23-32	signal transducer and activator of transcription 3	Homo sapiens	70-75
17505005-5	2007	Capsaicin also inhibited the interleukin-6-induced STAT3 activation.	Capsaicin	0-9	interleukin 6	Homo sapiens	29-42
17505005-5	2007	Capsaicin also inhibited the interleukin-6-induced STAT3 activation.	Capsaicin	0-9	signal transducer and activator of transcription 3	Homo sapiens	51-56
17505005-6	2007	The activation of Janus-activated kinase 1 and c-Src, implicated in STAT3 activation, was also inhibited by the vanilloid, with no effect on extracellular signal-regulated kinase 1/2 activation.	Capsaicin	112-121	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	47-52
17505005-6	2007	The activation of Janus-activated kinase 1 and c-Src, implicated in STAT3 activation, was also inhibited by the vanilloid, with no effect on extracellular signal-regulated kinase 1/2 activation.	Capsaicin	112-121	signal transducer and activator of transcription 3	Homo sapiens	68-73
17505005-7	2007	Pervanadate reversed the capsaicin-induced down-regulation of STAT3, suggesting the involvement of a protein tyrosine phosphatase.	Capsaicin	25-34	signal transducer and activator of transcription 3	Homo sapiens	62-67
17505005-8	2007	Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.	Capsaicin	0-9	signal transducer and activator of transcription 3	Homo sapiens	47-52
17505005-8	2007	Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.	Capsaicin	0-9	cyclin D1	Homo sapiens	86-95
17505005-8	2007	Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.	Capsaicin	0-9	BCL2 apoptosis regulator	Homo sapiens	97-102
17505005-8	2007	Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.	Capsaicin	0-9	BCL2 like 1	Homo sapiens	104-110
17505005-8	2007	Capsaicin down-regulated the expression of the STAT3-regulated gene products, such as cyclin D1, Bcl-2, Bcl-xL, survivin, and vascular endothelial growth factor.	Capsaicin	0-9	vascular endothelial growth factor A	Homo sapiens	126-160
17505005-12	2007	CONCLUSION: Overall, these results suggest that capsaicin is a novel blocker of the STAT3 activation pathway, with a potential role in the prevention and treatment of multiple myeloma and other cancers.	Capsaicin	48-57	signal transducer and activator of transcription 3	Homo sapiens	84-89
17362879-1	2007	Capsaicin (Cap) and its analogs (CAPanalogs) have diverse effects in sensory neurons including analgesia, implying they modulate other cellular targets besides the TRPV1 Cap receptor.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	164-169
17362879-1	2007	Capsaicin (Cap) and its analogs (CAPanalogs) have diverse effects in sensory neurons including analgesia, implying they modulate other cellular targets besides the TRPV1 Cap receptor.	Capsaicin	0-3	transient receptor potential cation channel subfamily V member 1	Homo sapiens	164-169
17565537-7	2007	Furthermore, they express capsaicin receptor transient receptor potential vanilloid family-1 (TRPV-1) and respond to capsaicin with increases in intracellular calcium.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	94-100
17343884-0	2007	Capsaicin treatment differentially affects feeding suppression by bombesin-like peptides.	Capsaicin	0-9	gastrin releasing peptide	Homo sapiens	66-74
17343884-4	2007	Our results demonstrate that capsaicin treatment abolished or attenuated the suppression of glucose intake produced by BN and NMB but had no effect on the ability of GRP to reduce feeding.	Capsaicin	29-38	neuromedin B	Rattus norvegicus	126-129
17456676-1	2007	BACKGROUND: The vanilloid receptors (TRPV1) are found in peripheral nerve fibers; their stimulation by capsaicin leads to release of calcitonin gene-related peptide and other neuropeptides participating in neuroinflammation.	Capsaicin	103-112	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-42
17237150-1	2007	Airways are densely innervated by capsaicin-sensitive sensory neurons expressing transient receptor potential vanilloid 1 (TRPV1) receptors/ion channels, which play an important regulatory role in inflammatory processes via the release of sensory neuropeptides.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	123-128
17306913-0	2007	Capsaicin induced apoptosis of B16-F10 melanoma cells through down-regulation of Bcl-2.	Capsaicin	0-9	B cell leukemia/lymphoma 2	Mus musculus	81-86
18690026-2	2007	TRPV1, a channel responsible for the burning pain sensation in response to heat, acid or capsaicin, is desensitized at high intracellular calcium concentrations.	Capsaicin	89-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
17203311-6	2007	For whole-mouth testing with capsaicin, a small but significant correlation was found between THR1 and THR2 (r (63) = 0.41).	Capsaicin	29-38	thyroid hormone receptor beta	Homo sapiens	94-98
17234710-8	2007	Ablation of vagal afferent function by perivagal application of capsaicin, a specific afferent neurotoxin, abolished c-fos protein immunoreactivity, suggesting that activation of the NTS due to GLP-2 is dependent on vagal afferents.	Capsaicin	64-73	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	117-122
17234710-8	2007	Ablation of vagal afferent function by perivagal application of capsaicin, a specific afferent neurotoxin, abolished c-fos protein immunoreactivity, suggesting that activation of the NTS due to GLP-2 is dependent on vagal afferents.	Capsaicin	64-73	mast cell protease 10	Rattus norvegicus	194-199
17346705-4	2007	Capsaicin, activating TRPV1 receptors on small sensory afferents, induces enhanced cellular activity in dorsal horn neurons and produces a central mediated area of secondary hyperalgesia.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
17306913-5	2007	Treatment of B16-F10 cells with capsaicin caused release of mitochondrial cytochrome c, activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase in a dose-dependent manner.	Capsaicin	32-41	caspase 3	Mus musculus	102-111
17306913-5	2007	Treatment of B16-F10 cells with capsaicin caused release of mitochondrial cytochrome c, activation of caspase-3, and cleavage of poly (ADP-ribose) polymerase in a dose-dependent manner.	Capsaicin	32-41	poly (ADP-ribose) polymerase family, member 1	Mus musculus	129-157
17306913-6	2007	Furthermore, Bcl-2 expression in the B16-F10 cells was slightly down-regulated by capsaicin treatment.	Capsaicin	82-91	B cell leukemia/lymphoma 2	Mus musculus	13-18
17306913-8	2007	Collectively, these findings indicate that capsaicin-induces apoptosis of B16-F10 melanoma cells via down-regulation the Bcl-2.	Capsaicin	43-52	B cell leukemia/lymphoma 2	Mus musculus	121-126
17351665-6	2007	Broncho-alveolar lavage (BAL) fluid analysis performed 60 min after capsaicin revealed increased mucin concentration.	Capsaicin	68-77	solute carrier family 13 member 2	Rattus norvegicus	97-102
17346695-12	2007	Whereas, TRPV1 agonists, capsaicin and piperine, inhibited gastric lesions induced by ethanol, 1% ammonia, and aspirin, but had less of an effect on 0.6 M HCl-induced gastric lesions.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-14
17341586-1	2007	TRPV4, a Ca(2+)-permeable member of the vanilloid subgroup of the transient receptor potential (TRP) channels, is activated by cell swelling and moderate heat (>27 degrees C) as well as by diverse chemical compounds including synthetic 4 alpha-phorbol esters, the plant extract bisandrographolide A, and endogenous epoxyeicosatrienoic acids (EETs; 5,6-EET and 8,9-EET).	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 4	Homo sapiens	0-5
17347480-11	2007	The reduced TRPV1 expression in visceral adipose tissue from obese humans was accompanied by reduced capsaicin-induced calcium influx.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
17347480-13	2007	We conclude that the activation of TRPV1 channels by capsaicin prevented adipogenesis and obesity.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	35-40
17306834-0	2007	Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer"s patch cells ex vivo.	Capsaicin	30-39	interleukin 2	Mus musculus	48-61
17306834-0	2007	Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer"s patch cells ex vivo.	Capsaicin	30-39	interferon gamma	Mus musculus	66-82
17306834-7	2007	The capsaicin-induced enhancement of both IL-2 and IFN-gamma production was not reduced by oral administration of capsazepine (3 mg/kg/day), suggesting a TRPV1 receptor-independent mechanism.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	154-159
17306835-0	2007	Capsaicin induces the production of IL-6 in human upper respiratory epithelial cells.	Capsaicin	0-9	interleukin 6	Homo sapiens	36-40
17306835-4	2007	In order to clarify whether or not TRPV1 acts as a functional receptor, we examined the effects of capsaicin on the production of IL-6 from primary cultured human airway epithelial cells at both protein and mRNA levels.	Capsaicin	99-108	interleukin 6	Homo sapiens	130-134
17306835-7	2007	Capsaicin (10 nM-10 muM) induced production of IL-6 from HNECs and NHBE cells and this effect was inhibited by pretreatment with capsazepine.	Capsaicin	0-9	interleukin 6	Homo sapiens	47-51
17306835-8	2007	Our findings suggest that topical application of capsaicin to the airway induces IL-6 production from respiratory epithelial cells via activation of TRPV1.	Capsaicin	49-58	interleukin 6	Homo sapiens	81-85
17306835-8	2007	Our findings suggest that topical application of capsaicin to the airway induces IL-6 production from respiratory epithelial cells via activation of TRPV1.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
17317009-2	2007	By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in spinal lamina II neurons from post-natal mice.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	120-140
17317009-2	2007	By patch clamp recordings and correlative immunocytochemistry, we studied here the effect of 2 microM capsaicin-induced vanilloid receptor-1 (TRPV1) activation on IPSCs in spinal lamina II neurons from post-natal mice.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	142-147
17347480-1	2007	We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	44-89
17347480-1	2007	We tested the hypothesis that activation of transient receptor potential vanilloid type-1 (TRPV1) by capsaicin prevents adipogenesis.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	91-96
17347480-7	2007	In vitro, the TRPV1 agonist capsaicin dose-dependently induced calcium influx and prevented the adipogenesis in stimulated 3T3-L1-preadipocytes.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
17347480-8	2007	RNA interference knockdown of TRPV1 in 3T3-L1-preadipocytes attenuated capsaicin-induced calcium influx, and adipogenesis in stimulated 3T3-L1-preadipocytes was no longer prevented.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	30-35
17303079-0	2007	Capsaicin induces cofilin dephosphorylation in human intestinal cells: the triggering role of cofilin in tight-junction signaling.	Capsaicin	0-9	cofilin 1	Homo sapiens	18-25
17303079-0	2007	Capsaicin induces cofilin dephosphorylation in human intestinal cells: the triggering role of cofilin in tight-junction signaling.	Capsaicin	0-9	cofilin 1	Homo sapiens	94-101
17303079-3	2007	Phosphorylated cofilin was decreased significantly by capsaicin treatment.	Capsaicin	54-63	cofilin 1	Homo sapiens	15-22
17303079-4	2007	In addition, capsaicin induced Ca2+ influx in Caco-2 cells and there was a clear correlation between Ca2+) influx and cofilin dephosphorylation (activation).	Capsaicin	13-22	cofilin 1	Homo sapiens	118-125
17303079-5	2007	The Ca2+-chelating reagent EGTA blocked the cofilin dephosphorylation induced by both capsaicin and ionomycin, suggesting that the dephosphorylation was mediated by Ca2+ influx.	Capsaicin	86-95	cofilin 1	Homo sapiens	44-51
17303079-7	2007	Our data suggest that TJ opening is mediated by cofilin dephosphorylation, which is caused by capsaicin stimuli, including Ca2+ influx.	Capsaicin	94-103	cofilin 1	Homo sapiens	48-55
17303079-8	2007	This is the first report of capsaicin action via the dephosphorylation of cofilin in human intestinal cells.	Capsaicin	28-37	cofilin 1	Homo sapiens	74-81
17287441-13	2007	We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-158
17307377-0	2007	Effect of topical application of capsaicin and its related compounds on dermal insulin-like growth factor-I levels in mice and on facial skin elasticity in humans.	Capsaicin	33-42	insulin-like growth factor 1	Mus musculus	79-107
17307377-1	2007	Capsaicin increases calcitonin gene-related peptide (CGRP) release from sensory neurons by stimulating vanilloid receptor-1 (VR-1).	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	20-51
17307377-1	2007	Capsaicin increases calcitonin gene-related peptide (CGRP) release from sensory neurons by stimulating vanilloid receptor-1 (VR-1).	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	53-57
17307377-1	2007	Capsaicin increases calcitonin gene-related peptide (CGRP) release from sensory neurons by stimulating vanilloid receptor-1 (VR-1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	103-123
17307377-1	2007	Capsaicin increases calcitonin gene-related peptide (CGRP) release from sensory neurons by stimulating vanilloid receptor-1 (VR-1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	125-129
17307377-2	2007	Since CGRP increases production of insulin-like growth factor-I (IGF-I) in fetal osteoblasts in vitro, it is possible that sensory neuron activation by capsaicin increases production of IGF-I.	Capsaicin	152-161	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	6-10
17307377-2	2007	Since CGRP increases production of insulin-like growth factor-I (IGF-I) in fetal osteoblasts in vitro, it is possible that sensory neuron activation by capsaicin increases production of IGF-I.	Capsaicin	152-161	insulin-like growth factor 1	Mus musculus	186-191
17307377-3	2007	In the present study, we attempted to determine whether topical application of capsaicin and related compounds increases dermal IGF-I level in mice and whether it increases facial skin elasticity in humans.	Capsaicin	79-88	insulin-like growth factor 1	Mus musculus	128-133
17307377-4	2007	Topical application of 0.01% capsaicin significantly increased dermal IGF-I levels from 30 to 180min (p<0.01), but not at 360min, after application in mice.	Capsaicin	29-38	insulin-like growth factor 1	Mus musculus	70-75
17141941-7	2007	RESULTS: Capsaicin dose dependently induced modifications in pain behavior: closing of the eyes, hypolocomotion, and inflammatory changes: increase of inflammatory cell accumulation, COX2 expression, and plasma extravasation at the acute stage, but completely recovered at 1 wk.	Capsaicin	9-18	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	183-187
17307377-7	2007	These observations suggest that topical application of capsaicin and related compounds might be useful in the treatment of detrimental morphological changes of the skin in patients with growth hormone deficiency and those in the elderly by increasing dermal IGF-I levels.	Capsaicin	55-64	insulin like growth factor 1	Homo sapiens	258-263
17287441-13	2007	We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 2	Homo sapiens	163-168
17287441-13	2007	We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-158
17287441-13	2007	We conclude that heat sensitization in deep and superficial capsaicin and capsaicin-insensitive C and Adelta nociceptors varies with the distribution of TRPV1 and TRPV2 proteins.	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 2	Homo sapiens	163-168
17324588-4	2007	Pharmacological interference with p42/p44 mitogen activated protein kinase (MAPK) or phosphoinositide-3-kinase (PI3K), but not PLC abrogated sensitization of capsaicin responses.	Capsaicin	158-167	cyclin-dependent kinase 20	Mus musculus	34-37
17237256-4	2007	Capsaicin injection induced phosphorylated ERK5 (p-ERK5) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	0-9	mitogen-activated protein kinase 7	Homo sapiens	43-47
17237256-4	2007	Capsaicin injection induced phosphorylated ERK5 (p-ERK5) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	0-9	mitogen-activated protein kinase 7	Homo sapiens	51-55
17237256-4	2007	Capsaicin injection induced phosphorylated ERK5 (p-ERK5) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	128-137	mitogen-activated protein kinase 7	Homo sapiens	43-47
17237256-4	2007	Capsaicin injection induced phosphorylated ERK5 (p-ERK5) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	128-137	mitogen-activated protein kinase 7	Homo sapiens	51-55
17237256-9	2007	administration of ERK5 antisense oligodeoxynucleotide reversed heat hyperalgesia, but not mechanical allodynia, produced by capsaicin injection.	Capsaicin	124-133	mitogen-activated protein kinase 7	Homo sapiens	18-22
17485923-1	2007	Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, was suggested to mediate the inhibitory effect of capsaicin on the vagally mediated striated muscle contractions in the rat esophagus.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
17485923-1	2007	Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, was suggested to mediate the inhibitory effect of capsaicin on the vagally mediated striated muscle contractions in the rat esophagus.	Capsaicin	242-251	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
17324588-4	2007	Pharmacological interference with p42/p44 mitogen activated protein kinase (MAPK) or phosphoinositide-3-kinase (PI3K), but not PLC abrogated sensitization of capsaicin responses.	Capsaicin	158-167	mitogen-activated protein kinase 3	Mus musculus	38-41
17324588-4	2007	Pharmacological interference with p42/p44 mitogen activated protein kinase (MAPK) or phosphoinositide-3-kinase (PI3K), but not PLC abrogated sensitization of capsaicin responses.	Capsaicin	158-167	mitogen-activated protein kinase 3	Mus musculus	76-80
17324588-4	2007	Pharmacological interference with p42/p44 mitogen activated protein kinase (MAPK) or phosphoinositide-3-kinase (PI3K), but not PLC abrogated sensitization of capsaicin responses.	Capsaicin	158-167	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	85-110
17324588-8	2007	Finally, NGF sensitization of capsaicin responses was greatly reduced in neurons from p85alpha (regulatory subunit of PI3K) null mice.	Capsaicin	30-39	phosphoinositide-3-kinase regulatory subunit 1	Mus musculus	86-94
17333213-0	2007	Exogenous calcitonin gene-related peptide perturbs the direction and length of gubernaculum in capsaicin-treated rats.	Capsaicin	95-104	calcitonin-related polypeptide alpha	Rattus norvegicus	10-41
17360009-0	2007	Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice.	Capsaicin	34-43	insulin-like growth factor 1	Mus musculus	71-76
17360009-2	2007	We examined whether stimulation of sensory neurons by capsaicin might reduce reperfusion-induced hepatic apoptosis by increasing IGF-I production.	Capsaicin	54-63	insulin-like growth factor 1	Mus musculus	129-134
17360009-3	2007	Administration of capsaicin increased tissue levels of IGF-I and IGF-I mRNA in various organs in wild-type (WT) mice, but not in CGRP-knock-out (CGRP-/-) mice.	Capsaicin	18-27	insulin-like growth factor 1	Mus musculus	55-60
17360009-3	2007	Administration of capsaicin increased tissue levels of IGF-I and IGF-I mRNA in various organs in wild-type (WT) mice, but not in CGRP-knock-out (CGRP-/-) mice.	Capsaicin	18-27	insulin-like growth factor 1	Mus musculus	65-70
17360009-7	2007	Although administration of capsaicin enhanced increases in IGF-I levels and reduced reperfusion-induced events in WT mice, it had no effect in CGRP-/- mice.	Capsaicin	27-36	insulin-like growth factor 1	Mus musculus	59-64
17360009-9	2007	These observations suggested that capsaicin-induced sensory neuron activation, which leads to release of CGRP, might increase IGF-I production, thereby reducing reperfusion-induced liver injury by reducing apoptosis.	Capsaicin	34-43	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	105-109
17360009-9	2007	These observations suggested that capsaicin-induced sensory neuron activation, which leads to release of CGRP, might increase IGF-I production, thereby reducing reperfusion-induced liver injury by reducing apoptosis.	Capsaicin	34-43	insulin-like growth factor 1	Mus musculus	126-131
17392452-1	2007	The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons (pH <5.7), and heat.	Capsaicin	162-171	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	23-28
17140857-1	2007	Previous studies have shown that heat stress possesses cardioprotection, which is related to the synthesis and release of calcitonin gene-related peptide (CGRP) via activation of capsaicin receptor (vanilloid receptor subtype 1, VR1) on the capsaicin-sensitive sensory neurons.	Capsaicin	179-188	calcitonin related polypeptide alpha	Homo sapiens	122-153
17140857-1	2007	Previous studies have shown that heat stress possesses cardioprotection, which is related to the synthesis and release of calcitonin gene-related peptide (CGRP) via activation of capsaicin receptor (vanilloid receptor subtype 1, VR1) on the capsaicin-sensitive sensory neurons.	Capsaicin	179-188	calcitonin related polypeptide alpha	Homo sapiens	155-159
17140857-1	2007	Previous studies have shown that heat stress possesses cardioprotection, which is related to the synthesis and release of calcitonin gene-related peptide (CGRP) via activation of capsaicin receptor (vanilloid receptor subtype 1, VR1) on the capsaicin-sensitive sensory neurons.	Capsaicin	179-188	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-227
17140857-1	2007	Previous studies have shown that heat stress possesses cardioprotection, which is related to the synthesis and release of calcitonin gene-related peptide (CGRP) via activation of capsaicin receptor (vanilloid receptor subtype 1, VR1) on the capsaicin-sensitive sensory neurons.	Capsaicin	179-188	transient receptor potential cation channel subfamily V member 1	Homo sapiens	229-232
17392452-1	2007	The vanilloid receptor TRPV1 (transient receptor potential vanilloid 1) is a cation channel that serves as a polymodal detector of pain-producing stimuli such as capsaicin, protons (pH <5.7), and heat.	Capsaicin	162-171	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	30-70
17295509-9	2007	The induction of apoptosis in 3T3-L1 preadipocytes by capsaicin was mediated through the activation of caspase-3, Bax, and Bak, and then through the cleavage of PARP and the down-regulation of Bcl-2.	Capsaicin	54-63	caspase 3	Mus musculus	103-112
17239544-2	2007	In this study, we determined if removal of TRPV1-expressing afferent neurons by resiniferatoxin (RTX), an ultrapotent capsaicin analog, influences the development of opioid analgesic tolerance.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	43-48
17295509-9	2007	The induction of apoptosis in 3T3-L1 preadipocytes by capsaicin was mediated through the activation of caspase-3, Bax, and Bak, and then through the cleavage of PARP and the down-regulation of Bcl-2.	Capsaicin	54-63	BCL2-associated X protein	Mus musculus	114-117
17295509-10	2007	Moreover, capsaicin significantly decreased the amount of intracellular triglycerides and glycerol-3-phosphate dehydrogenase (GPDH) activity in 3T3-L1 adipocytes.	Capsaicin	10-19	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	126-130
17295509-9	2007	The induction of apoptosis in 3T3-L1 preadipocytes by capsaicin was mediated through the activation of caspase-3, Bax, and Bak, and then through the cleavage of PARP and the down-regulation of Bcl-2.	Capsaicin	54-63	poly (ADP-ribose) polymerase family, member 1	Mus musculus	161-165
17295509-11	2007	Capsaicin also inhibited the expression of PPARgamma, C/EBPalpha, and leptin, but induced up-regulation of adiponectin at the protein level.	Capsaicin	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	43-52
17295509-9	2007	The induction of apoptosis in 3T3-L1 preadipocytes by capsaicin was mediated through the activation of caspase-3, Bax, and Bak, and then through the cleavage of PARP and the down-regulation of Bcl-2.	Capsaicin	54-63	B cell leukemia/lymphoma 2	Mus musculus	193-198
17295509-11	2007	Capsaicin also inhibited the expression of PPARgamma, C/EBPalpha, and leptin, but induced up-regulation of adiponectin at the protein level.	Capsaicin	0-9	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	54-64
17295509-11	2007	Capsaicin also inhibited the expression of PPARgamma, C/EBPalpha, and leptin, but induced up-regulation of adiponectin at the protein level.	Capsaicin	0-9	adiponectin, C1Q and collagen domain containing	Mus musculus	107-118
17295509-10	2007	Moreover, capsaicin significantly decreased the amount of intracellular triglycerides and glycerol-3-phosphate dehydrogenase (GPDH) activity in 3T3-L1 adipocytes.	Capsaicin	10-19	glycerol phosphate dehydrogenase 2, mitochondrial	Mus musculus	90-124
17122331-3	2007	Because it has been reported that systemic or perivagal capsaicin pretreatment abolishes the effects of CCK, the aim of the present work was to investigate the response of cNTS neurons to CCK-8s in vagally deafferented rats.	Capsaicin	56-65	cholecystokinin	Rattus norvegicus	104-107
17214968-5	2007	These data support the hypothesis that (E)-capsaicin, resiniferatoxin, capsazepine, and SB366791 are all mitochondrial inhibitors, able to activate apoptosis and/or necrosis via non-receptor mediated mechanisms, and also support the use of TRPV1 ligands as anti-cancer agents.	Capsaicin	39-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	240-245
17344381-6	2007	Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	172-177
17344381-6	2007	Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected.	Capsaicin	13-22	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	223-228
17344381-6	2007	Responses to capsaicin, menthol, and cinnamaldehyde were first seen at E12.5, E16.5, and postnatal day 0 (P0), when the mRNA for TRP cation channel, subfamily V, member 1 (TRPV1), TRP cation channel, subfamily M, member 8 (TRPM8), and TRP cation channel, subfamily A, member 1 (TRPA1), respectively, was first detected.	Capsaicin	13-22	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	278-283
17122331-3	2007	Because it has been reported that systemic or perivagal capsaicin pretreatment abolishes the effects of CCK, the aim of the present work was to investigate the response of cNTS neurons to CCK-8s in vagally deafferented rats.	Capsaicin	56-65	cholecystokinin	Rattus norvegicus	188-191
17353553-4	2007	Here we explore how changes in tonicity affect TRPV1 receptor-mediated responses to capsaicin in dissociated rat trigeminal ganglion (TG) neurons.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	47-52
17329854-6	2007	These findings indicate that capsaicin affects both transcellular and paracellular pathways of intestinal cephalexin absorption by interacting with the TRP cation channels in intestinal tissues, in which capsaicin seems to change the transport activity of H+/peptide co-transporter 1 (PEPT1), and to a lesser degree, it seems to alter the paracellular permeability of the intestinal epithelia.	Capsaicin	29-38	solute carrier family 15 member 1	Rattus norvegicus	256-283
17329854-6	2007	These findings indicate that capsaicin affects both transcellular and paracellular pathways of intestinal cephalexin absorption by interacting with the TRP cation channels in intestinal tissues, in which capsaicin seems to change the transport activity of H+/peptide co-transporter 1 (PEPT1), and to a lesser degree, it seems to alter the paracellular permeability of the intestinal epithelia.	Capsaicin	29-38	solute carrier family 15 member 1	Rattus norvegicus	285-290
17329854-6	2007	These findings indicate that capsaicin affects both transcellular and paracellular pathways of intestinal cephalexin absorption by interacting with the TRP cation channels in intestinal tissues, in which capsaicin seems to change the transport activity of H+/peptide co-transporter 1 (PEPT1), and to a lesser degree, it seems to alter the paracellular permeability of the intestinal epithelia.	Capsaicin	204-213	solute carrier family 15 member 1	Rattus norvegicus	256-283
17329854-6	2007	These findings indicate that capsaicin affects both transcellular and paracellular pathways of intestinal cephalexin absorption by interacting with the TRP cation channels in intestinal tissues, in which capsaicin seems to change the transport activity of H+/peptide co-transporter 1 (PEPT1), and to a lesser degree, it seems to alter the paracellular permeability of the intestinal epithelia.	Capsaicin	204-213	solute carrier family 15 member 1	Rattus norvegicus	285-290
17298290-2	2007	TRPV1 is a non-selective cation channel gated by noxious heat, protons and capsaicin, thus being regarded as a polymodal molecular integrator in nociception.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
17298290-4	2007	By activating multiple protein kinases to increase the phosphorylation of TRPV1, pronociceptive inflammatory mediators sensitise the TRPV1 response to noxious heat, protons and capsaicin, thus augmenting thermal hyperalgesia.	Capsaicin	177-186	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
17298290-4	2007	By activating multiple protein kinases to increase the phosphorylation of TRPV1, pronociceptive inflammatory mediators sensitise the TRPV1 response to noxious heat, protons and capsaicin, thus augmenting thermal hyperalgesia.	Capsaicin	177-186	transient receptor potential cation channel subfamily V member 1	Homo sapiens	133-138
17068482-5	2007	Capsaicin, an activator of TRPV1, delayed barrier recovery, whereas capsazepin, an antagonist of TRPV1, blocked this delay.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
17425556-4	2007	These results suggest that alphabetameATP acts on P2X receptors, possibly P2X(3) and/or P2X(2/3), in capsaicin-sensitive primary afferent terminals.	Capsaicin	101-110	purinergic receptor P2X 3	Rattus norvegicus	74-80
17425556-4	2007	These results suggest that alphabetameATP acts on P2X receptors, possibly P2X(3) and/or P2X(2/3), in capsaicin-sensitive primary afferent terminals.	Capsaicin	101-110	purinergic receptor P2X 2	Rattus norvegicus	88-95
17295025-1	2007	Capsaicin, a pungent constituent from red chilli peppers, activates sensory nerve fibres via transient receptor potential vanilloid receptors type 1 (TRPV1) to release neuropeptides like calcitonin gene-related peptide (CGRP) and substance P.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	150-155
17295025-13	2007	Therefore, these relaxant responses to capsaicin are likely to be attributed to a non-specific, CGRP-independent mechanism.	Capsaicin	39-48	calcitonin related polypeptide alpha	Homo sapiens	96-100
17295025-1	2007	Capsaicin, a pungent constituent from red chilli peppers, activates sensory nerve fibres via transient receptor potential vanilloid receptors type 1 (TRPV1) to release neuropeptides like calcitonin gene-related peptide (CGRP) and substance P.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	187-218
17295025-1	2007	Capsaicin, a pungent constituent from red chilli peppers, activates sensory nerve fibres via transient receptor potential vanilloid receptors type 1 (TRPV1) to release neuropeptides like calcitonin gene-related peptide (CGRP) and substance P.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	220-224
17295025-1	2007	Capsaicin, a pungent constituent from red chilli peppers, activates sensory nerve fibres via transient receptor potential vanilloid receptors type 1 (TRPV1) to release neuropeptides like calcitonin gene-related peptide (CGRP) and substance P.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	230-241
17156774-1	2007	Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory effect of capsaicin on vagally mediated striated muscle contractions in the rat esophagus.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
17304317-6	2007	Capsaicin could induce a significant increase in secretion of rabbit SMG via activitation of VR1.	Capsaicin	0-9	sterile alpha motif domain containing 4A	Homo sapiens	69-72
17156774-5	2007	Ruthenium red (10 microM; a non-selective blocker of transient receptor potential cation channels) and SB-366791 (10 microM; a novel selective antagonist of TRPV1) blocked the inhibitory effect of capsaicin but not that of piperine.	Capsaicin	197-206	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	157-162
17156774-7	2007	Desensitization of TRPV1 in the mouse esophagus by in vitro pretreatment with capsaicin failed to affect the inhibitory effect of piperine, whereas the piperine effect was cross-desensitized by capsaicin pretreatment in rat and hamster esophagi.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
17156774-7	2007	Desensitization of TRPV1 in the mouse esophagus by in vitro pretreatment with capsaicin failed to affect the inhibitory effect of piperine, whereas the piperine effect was cross-desensitized by capsaicin pretreatment in rat and hamster esophagi.	Capsaicin	194-203	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
17184917-0	2007	Kv7.2-7.5 voltage-gated potassium channel (KCNQ2-5) opener, retigabine, reduces capsaicin-induced visceral pain in mice.	Capsaicin	80-89	potassium voltage-gated channel, subfamily Q, member 2	Mus musculus	43-50
17156774-1	2007	Transient receptor potential ion channel of the vanilloid type 1 (TRPV1)-dependent pathway, consisting of capsaicin-sensitive tachykininergic primary afferent and myenteric nitrergic neurons, has been suggested to mediate the inhibitory effect of capsaicin on vagally mediated striated muscle contractions in the rat esophagus.	Capsaicin	247-256	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
17156774-2	2007	In a recent study, similar but also different effects of capsaicin and piperine on TRPV1 were demonstrated.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	83-88
17244257-2	2007	The VR1 modulatory drugs capsaicin, olvanil and capsazepine inhibited the binding of batrachotoxinin-A 20-alpha-benzoate ([(3)H]BTX-B) to receptor site 2 of voltage-gated sodium channels.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-7
17151223-11	2007	Most menthol-responsive units also responded to the TRPA1 agonists cinnamaldehyde and mustard oil, and the TRPV1 agonist capsaicin.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	107-112
17161658-2	2007	The vanilloid (capsaicin) channel TRPV4 is sensitive to osmotic changes and plays a central role in osmoregulatory responses in a variety of organisms.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 4	Danio rerio	34-39
17161658-2	2007	The vanilloid (capsaicin) channel TRPV4 is sensitive to osmotic changes and plays a central role in osmoregulatory responses in a variety of organisms.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 4	Danio rerio	34-39
17182914-5	2007	The increased responses to NMDA after capsaicin were attenuated by iontophoretic application of the selective NK-1 receptor antagonist L-733,060.	Capsaicin	38-47	tachykinin receptor 1	Rattus norvegicus	110-123
17182914-6	2007	Similarly to capsaicin, iontophoretic application of the selective NK-1 receptor agonist, [Sar(9),Met(O(2))(11)]-substance P (SM-SP), increased the spontaneous discharge rate and NMDA-evoked responses of on cells by >100% of control values.	Capsaicin	13-22	tachykinin receptor 1	Rattus norvegicus	67-80
16777226-1	2007	The vanilloid receptor family of cation channels includes the capsaicin-sensitive, proton- and heat-activated TRPV1 and noxious heat-activated TRPV2.	Capsaicin	62-71	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
17084039-0	2007	Activation of protein kinase B/Akt in the periphery contributes to pain behavior induced by capsaicin in rats.	Capsaicin	92-101	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
17194758-1	2007	Transient receptor potential vanilloid 1 (TRPV1), a ligand-gated cation channel highly expressed in small-diameter sensory neurons, is activated by heat, protons, and capsaicin.	Capsaicin	167-176	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
17194758-1	2007	Transient receptor potential vanilloid 1 (TRPV1), a ligand-gated cation channel highly expressed in small-diameter sensory neurons, is activated by heat, protons, and capsaicin.	Capsaicin	167-176	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
17110039-1	2007	TRPV1 is a cation channel which is activated by temperature (> or =42 degrees C) and capsaicin.	Capsaicin	88-97	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
17110039-6	2007	These results suggest that the decreased expression of TRPV1 may be related to a functional knock out in capsaicin sensation and hypersensitivity to allicin in humans.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-60
17084039-5	2007	In this study, we investigated whether PKB/Akt in primary sensory neurons is activated after noxious stimulation and contributes to pain behavior induced in rats by capsaicin.	Capsaicin	165-174	AKT serine/threonine kinase 1	Rattus norvegicus	39-42
17084039-5	2007	In this study, we investigated whether PKB/Akt in primary sensory neurons is activated after noxious stimulation and contributes to pain behavior induced in rats by capsaicin.	Capsaicin	165-174	AKT serine/threonine kinase 1	Rattus norvegicus	43-46
17084039-6	2007	We demonstrated that phospho-PKB/Akt (p-PKB/Akt) is increased in dorsal root ganglia (DRG) at 5 min after intradermal injection of capsaicin.	Capsaicin	131-140	AKT serine/threonine kinase 1	Rattus norvegicus	21-36
17084039-6	2007	We demonstrated that phospho-PKB/Akt (p-PKB/Akt) is increased in dorsal root ganglia (DRG) at 5 min after intradermal injection of capsaicin.	Capsaicin	131-140	AKT serine/threonine kinase 1	Rattus norvegicus	38-47
17084039-8	2007	After capsaicin injection, p-PKB/Akt (473) is colocalized with isotectin-B4 (IB4), tyrosine kinase A (TrkA), and calcitonin gene-related peptide (CGRP).	Capsaicin	6-15	AKT serine/threonine kinase 1	Rattus norvegicus	27-36
17084039-8	2007	After capsaicin injection, p-PKB/Akt (473) is colocalized with isotectin-B4 (IB4), tyrosine kinase A (TrkA), and calcitonin gene-related peptide (CGRP).	Capsaicin	6-15	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	83-100
17084039-8	2007	After capsaicin injection, p-PKB/Akt (473) is colocalized with isotectin-B4 (IB4), tyrosine kinase A (TrkA), and calcitonin gene-related peptide (CGRP).	Capsaicin	6-15	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	102-106
17084039-8	2007	After capsaicin injection, p-PKB/Akt (473) is colocalized with isotectin-B4 (IB4), tyrosine kinase A (TrkA), and calcitonin gene-related peptide (CGRP).	Capsaicin	6-15	calcitonin-related polypeptide alpha	Rattus norvegicus	113-144
21204492-3	2007	TRPV1, the first member of the TRPV family and the sensory neuron receptor for vanilloid ligands like capsaicin, which is also responsive to noxious heat (>42 C), was found by expression cloning [4], as were the more distantly related epithelial Ca(2+) channels TRPV5 [5] and TRPV6 [6].	Capsaicin	102-111	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
21204492-3	2007	TRPV1, the first member of the TRPV family and the sensory neuron receptor for vanilloid ligands like capsaicin, which is also responsive to noxious heat (>42 C), was found by expression cloning [4], as were the more distantly related epithelial Ca(2+) channels TRPV5 [5] and TRPV6 [6].	Capsaicin	102-111	transient receptor potential cation channel subfamily V member 5	Homo sapiens	265-270
21204492-3	2007	TRPV1, the first member of the TRPV family and the sensory neuron receptor for vanilloid ligands like capsaicin, which is also responsive to noxious heat (>42 C), was found by expression cloning [4], as were the more distantly related epithelial Ca(2+) channels TRPV5 [5] and TRPV6 [6].	Capsaicin	102-111	transient receptor potential cation channel subfamily V member 6	Homo sapiens	279-284
17084039-10	2007	Behavioral experiments show that intradermal injection of a PI3K (upstream of PKB/Akt) inhibitor, wortmannin, dose-dependently inhibits the changes in exploratory behavior evoked by capsaicin injection.	Capsaicin	182-191	AKT serine/threonine kinase 1	Rattus norvegicus	78-81
21204495-0	2007	Complex Regulation of TRPV1 by Vanilloids A subset of sensory neurons is characterized by a unique sensitivity to capsaicin, the piquant ingredient in hot chili peppers [1].	Capsaicin	114-123	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
21204495-3	2007	Capsaicin evokes these responses by interacting at a specific membrane recognition site, originally termed the vanilloid receptor [1].	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	111-133
17084039-10	2007	Behavioral experiments show that intradermal injection of a PI3K (upstream of PKB/Akt) inhibitor, wortmannin, dose-dependently inhibits the changes in exploratory behavior evoked by capsaicin injection.	Capsaicin	182-191	AKT serine/threonine kinase 1	Rattus norvegicus	82-85
16973931-5	2007	Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches.	Capsaicin	107-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-68
17008557-10	2007	The sustained contraction was inhibited by capsaicin and neurokinin NK2 receptor antagonist, suggesting that it is mediated by substance P (SP).	Capsaicin	43-52	tachykinin 1	Mus musculus	127-138
17404062-0	2007	Involvement of AMPK signaling cascade in capsaicin-induced apoptosis of HT-29 colon cancer cells.	Capsaicin	41-50	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	15-19
17404062-4	2007	In this article, we have investigated the effects of capsaicin on apoptosis in relation to AMPK activation in colon cancer cell.	Capsaicin	53-62	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	91-95
17404062-6	2007	Concomitantly, the activation of AMPK and the increased expression of the inactive form of acetyl-CoA carboxylase (ACC) were detected in capsaicin-treated colon cancer cells.	Capsaicin	137-146	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	33-37
17404062-7	2007	We showed that both capsaicin and 5"-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR), an AMPK activator possess the AMPK-activating capacity as well as apoptosis-inducing properties.	Capsaicin	20-29	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	102-106
17404062-7	2007	We showed that both capsaicin and 5"-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside (AICAR), an AMPK activator possess the AMPK-activating capacity as well as apoptosis-inducing properties.	Capsaicin	20-29	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	129-133
17404062-8	2007	Evidence of the association between AMPK activation and the increased apoptosis in HT-29 colon cancer cells by capsaicin treatment, and further findings of the correlation of the activated AMPK and the elevated apoptosis by cotreatment of AICAR and capsaicin support AMPK as an important component of apoptosis, as well as a possible target of cancer control.	Capsaicin	111-120	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	36-40
17404062-8	2007	Evidence of the association between AMPK activation and the increased apoptosis in HT-29 colon cancer cells by capsaicin treatment, and further findings of the correlation of the activated AMPK and the elevated apoptosis by cotreatment of AICAR and capsaicin support AMPK as an important component of apoptosis, as well as a possible target of cancer control.	Capsaicin	249-258	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	189-193
17404062-8	2007	Evidence of the association between AMPK activation and the increased apoptosis in HT-29 colon cancer cells by capsaicin treatment, and further findings of the correlation of the activated AMPK and the elevated apoptosis by cotreatment of AICAR and capsaicin support AMPK as an important component of apoptosis, as well as a possible target of cancer control.	Capsaicin	249-258	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	189-193
16973931-5	2007	Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
16973931-5	2007	Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	298-303
16973931-5	2007	Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches.	Capsaicin	107-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
16973931-5	2007	Much of this work has involved one specific channel, TRP vanilloid 1 (TRPV1), which is both a receptor for capsaicin and related pungent vanilloid compounds and a "heat receptor," capable of directly depolarizing neurons in response to temperatures >42 degrees C. Evidence for a contribution of TRPV1 to peripheral thermosensation has come from pharmacological, physiological, and genetic approaches.	Capsaicin	107-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	298-303
17035013-0	2007	Halogenation of 4-hydroxy-3-methoxybenzyl thiourea TRPV1 agonists showed enhanced antagonism to capsaicin.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
17179954-5	2007	We found that PAR(4) colocalized with calcitonin gene-related peptide and substance P. We also showed that a selective PAR(4)-AP was able to inhibit calcium mobilization evoked by KCl and capsaicin in rat sensory neurons.	Capsaicin	188-197	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	14-20
17365137-48	2007	In pregnant mice dosed subcutaneously with Capsaicin, depletion of substance P in the spinal cord and peripheral nerves of pregnant females and fetuses was noted.	Capsaicin	43-52	tachykinin 1	Mus musculus	67-78
17241282-1	2007	The system that regulates insulin secretion from beta-cells in the islet of Langerhans has a capsaicin-sensitive inhibitory component.	Capsaicin	93-102	insulin	Homo sapiens	26-33
17241282-2	2007	As calcitonin gene-related peptide (CGRP)-expressing primary sensory fibers innervate the islets, and a major proportion of the CGRP-containing primary sensory neurons is sensitive to capsaicin, the islet-innervating sensory fibers may represent the capsaicin-sensitive inhibitory component.	Capsaicin	184-193	calcitonin related polypeptide alpha	Homo sapiens	128-132
17241282-3	2007	Here, we examined the expression of the capsaicin receptor, vanilloid type 1 transient receptor potential receptor (TRPV1) in CGRP-expressing fibers in the pancreatic islets, and the effect of selective elimination of capsaicin-sensitive primary afferents on the decline of glucose homeostasis and insulin secretion in Zucker diabetic fatty (ZDF) rats, which are used to study various aspects of human type 2 diabetes mellitus.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	126-130
17241282-7	2007	These data indicate that CGRP-containing fibers in the islets are capsaicin sensitive, and that elimination of these fibers contributes to the prevention of the deterioration of glucose homeostasis through increased insulin secretion in ZDF rats.	Capsaicin	66-75	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
16935424-12	2006	Treatment with AM-251 also reduced the depletion of CGRP, suppressed Fos-induction, and prevented the increase in capsaicin-evoked spinal CGRP release.	Capsaicin	114-123	calcitonin-related polypeptide alpha	Rattus norvegicus	138-142
17005903-8	2007	In whole-cell patch clamp studies, opioids significantly decreased capsaicin-induced TRPV1 currents in a naloxone- and pertussis toxinsensitive manner.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-90
16962240-1	2007	Capsaicin elicits burning pain via the activation of the vanilloid receptor (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
17173683-5	2006	Furthermore, in nodose ganglia cells, capsaicin induced Ca2+ influx through TRPV1 channel was inhibited via BCTC in a concentration dependent manner.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	76-81
17011108-8	2006	In contrast, pro-inflammatory cytokines, the Th2 cell cytokine IL-4, and the CC-chemokine MCP-1 were significantly increased in BAL-cells of capsaicin pretreated and MDI-sensitized rats, whilst in the normal MDI-sensitized rats markedly less pronounced changes (if any) occurred.	Capsaicin	141-150	interleukin 4	Rattus norvegicus	63-67
17011108-8	2006	In contrast, pro-inflammatory cytokines, the Th2 cell cytokine IL-4, and the CC-chemokine MCP-1 were significantly increased in BAL-cells of capsaicin pretreated and MDI-sensitized rats, whilst in the normal MDI-sensitized rats markedly less pronounced changes (if any) occurred.	Capsaicin	141-150	mast cell protease 1-like 1	Rattus norvegicus	90-95
16949718-3	2006	Furthermore, AEA binds to the transient receptor potential vanilloid type-1 (TRPV1), a capsaicin-sensitive, non-selective cation channel.	Capsaicin	87-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-75
16797124-9	2006	Our results show an important role of TRPV1-containing nociceptors in the development of post-surgical hypersensitivity and suggest that local, high-concentration capsaicin treatment could be used to reduce it.	Capsaicin	163-172	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	38-43
16797124-2	2006	The aim of this study was to evaluate the role of transient receptor potential vanilloid 1 receptor (TRPV1) containing nociceptors in this process, by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model.	Capsaicin	233-242	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	50-99
16797124-2	2006	The aim of this study was to evaluate the role of transient receptor potential vanilloid 1 receptor (TRPV1) containing nociceptors in this process, by their functional inactivation using a high-concentration intradermal injection of capsaicin in a rat plantar incision model.	Capsaicin	233-242	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-106
16887920-7	2006	Intrapericardial capsazepine (1 mg/ml, 0.2 ml, 3 min), a specific antagonist of TRPV1, sharply attenuated excitatory responses to CAP in 5/5 neurons, but responses to BK in 5/5 neurons was maintained.	Capsaicin	130-133	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	80-85
16949718-3	2006	Furthermore, AEA binds to the transient receptor potential vanilloid type-1 (TRPV1), a capsaicin-sensitive, non-selective cation channel.	Capsaicin	87-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
16996168-7	2006	Both capsaicin and NONOate caused significant increases in CGRP release.	Capsaicin	5-14	calcitonin related polypeptide alpha	Homo sapiens	59-63
17229097-9	2006	These data suggest that transport of both NADA and capsaicin into DRG neurons and the subsequent activation of TRPV1 is partly governed by FAAH-dependent mechanisms as well as via the putative AEA membrane transporter.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	111-116
17229097-9	2006	These data suggest that transport of both NADA and capsaicin into DRG neurons and the subsequent activation of TRPV1 is partly governed by FAAH-dependent mechanisms as well as via the putative AEA membrane transporter.	Capsaicin	51-60	fatty-acid amide hydrolase-like	Rattus norvegicus	139-143
17187013-0	2006	Butyrate sensitizes the release of substance P and calcitonin gene-related peptide evoked by capsaicin from primary cultured rat dorsal root ganglion neurons.	Capsaicin	93-102	calcitonin-related polypeptide alpha	Rattus norvegicus	51-82
17187013-1	2006	OBJECTIVES: To investigate whether butyrate increases substance P (SP) and calcitonin gene-related peptide (CGRP) release evoked by capsaicin from primary cultured dorsal root ganglion (DRG) neurons.	Capsaicin	132-141	calcitonin-related polypeptide alpha	Rattus norvegicus	75-106
17187013-1	2006	OBJECTIVES: To investigate whether butyrate increases substance P (SP) and calcitonin gene-related peptide (CGRP) release evoked by capsaicin from primary cultured dorsal root ganglion (DRG) neurons.	Capsaicin	132-141	calcitonin-related polypeptide alpha	Rattus norvegicus	108-112
17187013-10	2006	SP and CGRP release levels in the culture media exposed by butyrate at higher concentrations (1 mmol/L, 10 mmol/L) for 48 h and then stimulated by capsaicin were higher than that at lower concentrations (0.01 mmol/L, 0.1 mmol/L) (P<0.001).	Capsaicin	147-156	calcitonin-related polypeptide alpha	Rattus norvegicus	7-11
17187013-12	2006	DISCUSSION: Butyrate may promote the expression of mRNA for SP, CGRP and increase sensitivity of capsaicin on SP and CGRP release from primary cultured rat dorsal root ganglion neurons.	Capsaicin	97-106	calcitonin-related polypeptide alpha	Rattus norvegicus	117-121
17187013-13	2006	The promotion of VR1 mRNA and VR1 protein expression by butyrate implicated that VR1 may be involved in the mechanisms of sensory neuropeptide release evoked by capsaicin.	Capsaicin	161-170	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	17-20
17187013-13	2006	The promotion of VR1 mRNA and VR1 protein expression by butyrate implicated that VR1 may be involved in the mechanisms of sensory neuropeptide release evoked by capsaicin.	Capsaicin	161-170	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	30-33
17187013-13	2006	The promotion of VR1 mRNA and VR1 protein expression by butyrate implicated that VR1 may be involved in the mechanisms of sensory neuropeptide release evoked by capsaicin.	Capsaicin	161-170	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	30-33
17117942-6	2006	ARTN was also protective following capsaicin treatment, which produces selective C-fibre injury.	Capsaicin	35-44	artemin	Rattus norvegicus	0-4
17018028-0	2006	TRPV1b overexpression negatively regulates TRPV1 responsiveness to capsaicin, heat and low pH in HEK293 cells.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
16893949-0	2006	Association of genetic variations in neurokinin-2 receptor with enhanced cough sensitivity to capsaicin in chronic cough.	Capsaicin	94-103	tachykinin receptor 2	Homo sapiens	37-58
16893949-5	2006	The cough response to capsaicin was recorded for 312 patients with chronic cough, and the potential genetic association between cough sensitivity to capsaicin and the NK-1R and NK-2R genotypes was evaluated.	Capsaicin	149-158	tachykinin receptor 1	Homo sapiens	167-172
16893949-9	2006	CONCLUSIONS: The results of this study suggest that NK-2R gene polymorphisms are involved in the enhanced cough sensitivity to capsaicin of patients with chronic cough.	Capsaicin	127-136	tachykinin receptor 2	Homo sapiens	52-57
16938409-1	2006	Substance P (SP) and calcitonin gene-related peptide (CGRP), released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation, while somatostatin exerts systemic anti-inflammatory actions.	Capsaicin	75-84	calcitonin-related polypeptide alpha	Rattus norvegicus	21-52
16938409-1	2006	Substance P (SP) and calcitonin gene-related peptide (CGRP), released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation, while somatostatin exerts systemic anti-inflammatory actions.	Capsaicin	75-84	calcitonin-related polypeptide alpha	Rattus norvegicus	54-58
16938409-3	2006	Capsaicin (10(-6) M) or electrical field stimulation (EFS; 40 V, 0.1 ms, 10 Hz, 120 s; 1200 impulses)-induced release of PACAP-38, SP, CGRP and somatostatin from isolated rat tracheae was measured with radioimmunoassay.	Capsaicin	0-9	adenylate cyclase activating polypeptide 1	Rattus norvegicus	121-126
16938409-3	2006	Capsaicin (10(-6) M) or electrical field stimulation (EFS; 40 V, 0.1 ms, 10 Hz, 120 s; 1200 impulses)-induced release of PACAP-38, SP, CGRP and somatostatin from isolated rat tracheae was measured with radioimmunoassay.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	135-139
16938409-5	2006	Capsaicin and EFS evoked 27% and more than twofold elevation of PACAP-38 release respectively, compared with the prestimulated basal values from isolated trachea preparation.	Capsaicin	0-9	adenylate cyclase activating polypeptide 1	Rattus norvegicus	64-69
16938409-6	2006	Exogenously administered PACAP-38 (20-2000 nM) diminished both capsaicin- and EFS-evoked sensory neuropeptide release in a concentration-dependent manner.	Capsaicin	63-72	adenylate cyclase activating polypeptide 1	Rattus norvegicus	25-30
16938409-7	2006	The maximal inhibitory effects of PACAP on capsaicin-induced substance P, CGRP and somatostatin release amounted to 75.4%, 73.3% and 90.0%, while EFS-evoked release of these peptides was 80.03%, 87.7% and 67.7%.	Capsaicin	43-52	adenylate cyclase activating polypeptide 1	Rattus norvegicus	34-39
16938409-7	2006	The maximal inhibitory effects of PACAP on capsaicin-induced substance P, CGRP and somatostatin release amounted to 75.4%, 73.3% and 90.0%, while EFS-evoked release of these peptides was 80.03%, 87.7% and 67.7%.	Capsaicin	43-52	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
16938409-8	2006	In case of capsaicin stimulation the EC50 values for substance P, CGRP and somatostatin were 82.9 nM, 60.1 nM and 66.9 nM, respectively.	Capsaicin	11-20	calcitonin-related polypeptide alpha	Rattus norvegicus	66-70
16938409-14	2006	These results suggest that PACAP-38 is released from the stimulated peripheral terminals of capsaicin-sensitive afferents and it is able to inhibit the outflow of sensory neuropeptides.	Capsaicin	92-101	adenylate cyclase activating polypeptide 1	Rattus norvegicus	27-32
16950406-0	2006	Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1.	Capsaicin	17-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
16950406-1	2006	Analogs of capsaicin, such as capsaicinoids and capsinoids, activate a cation channel, transient receptor potential cation channel vanilloid subfamily 1 (TRPV1), and then increase the intracellular calcium concentration ([Ca2+]i).	Capsaicin	11-20	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	154-159
16950406-1	2006	Analogs of capsaicin, such as capsaicinoids and capsinoids, activate a cation channel, transient receptor potential cation channel vanilloid subfamily 1 (TRPV1), and then increase the intracellular calcium concentration ([Ca2+]i).	Capsaicin	30-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	154-159
17062748-4	2006	We tested the hypothesis that alterations in the tissue temperature and pH of isolated superfused rat dental pulp regulate capsaicin-induced release of calcitonin gene-related peptide (CGRP).	Capsaicin	123-132	calcitonin-related polypeptide alpha	Rattus norvegicus	152-183
17062748-4	2006	We tested the hypothesis that alterations in the tissue temperature and pH of isolated superfused rat dental pulp regulate capsaicin-induced release of calcitonin gene-related peptide (CGRP).	Capsaicin	123-132	calcitonin-related polypeptide alpha	Rattus norvegicus	185-189
17062748-5	2006	Application of capsaicin with increased proton concentration (i.e., lowered pH) produced a nearly two-fold increase in peak immunoreactive CGRP release, as compared with capsaicin applied at a pH of 7.4.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	139-143
16781076-2	2006	In this study, we evaluated whether agonists of PAR-2 activate the capsaicin-sensitive subclass of trigeminal nociceptors in a PLC-PKC-dependent manner and induce functional competence in the DOR.	Capsaicin	67-76	F2R like trypsin receptor 1	Rattus norvegicus	48-53
16764934-3	2006	These data demonstrate that somatostatin is released from capsaicin-sensitive, peptidergic sensory nerve endings in response to noxious heat and chemical stimuli such as vanilloids, protons or lipoxygenase products.	Capsaicin	58-67	somatostatin	Homo sapiens	28-40
17107623-8	2006	Mice lacking the PK2 gene displayed strong reduction in nociception induced by thermal and chemical stimuli, including capsaicin.	Capsaicin	119-128	prokineticin 2	Mus musculus	17-20
17107623-10	2006	As the majority of PK2-responsive DRG neurons also expressed transient receptor potential vanilloid (TRPV1) and exhibited sensitivity to capsaicin, TRPV1 is likely a significant downstream molecule of PK2 signaling.	Capsaicin	137-146	prokineticin 2	Mus musculus	19-22
17107623-10	2006	As the majority of PK2-responsive DRG neurons also expressed transient receptor potential vanilloid (TRPV1) and exhibited sensitivity to capsaicin, TRPV1 is likely a significant downstream molecule of PK2 signaling.	Capsaicin	137-146	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	148-153
17107623-10	2006	As the majority of PK2-responsive DRG neurons also expressed transient receptor potential vanilloid (TRPV1) and exhibited sensitivity to capsaicin, TRPV1 is likely a significant downstream molecule of PK2 signaling.	Capsaicin	137-146	prokineticin 2	Mus musculus	201-204
16908491-10	2006	These results suggest that TRPV1 serves as a receptor for both cyclohexanone and capsaicin in trigeminal nerve endings.	Capsaicin	81-90	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
17018028-8	2006	Moreover, when co-expressed with TRPV1, TRPV1b formed complexes with TRPV1, and inhibited TRPV1 channel function in response to capsaicin, acidic pH, heat and endogenous vanilloids, dose-dependently.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-38
17018028-8	2006	Moreover, when co-expressed with TRPV1, TRPV1b formed complexes with TRPV1, and inhibited TRPV1 channel function in response to capsaicin, acidic pH, heat and endogenous vanilloids, dose-dependently.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
17018028-8	2006	Moreover, when co-expressed with TRPV1, TRPV1b formed complexes with TRPV1, and inhibited TRPV1 channel function in response to capsaicin, acidic pH, heat and endogenous vanilloids, dose-dependently.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
16959413-0	2006	Effects of neonatal capsaicin treatment in the neutrophil production, and expression of preprotachykinin-I and tachykinin receptors in the rat bone marrow.	Capsaicin	20-29	tachykinin, precursor 1	Rattus norvegicus	88-104
16959413-9	2006	Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed that both preprotachykinin (PPT)-I mRNA and the tachykinin neurokinin (NK)-1 mRNA expression in bone marrow cells significantly increased in capsaicin group, whereas the NK-2 mRNA expression was unchanged after capsaicin pretreatment.	Capsaicin	223-232	tachykinin, precursor 1	Rattus norvegicus	92-108
16959413-9	2006	Semi-quantitative reverse transcriptase-polymerase chain reaction (RT-PCR) showed that both preprotachykinin (PPT)-I mRNA and the tachykinin neurokinin (NK)-1 mRNA expression in bone marrow cells significantly increased in capsaicin group, whereas the NK-2 mRNA expression was unchanged after capsaicin pretreatment.	Capsaicin	293-302	tachykinin, precursor 1	Rattus norvegicus	92-108
16942782-0	2006	Capsaicin induced cell cycle arrest and apoptosis in human esophagus epidermoid carcinoma CE 81T/VGH cells through the elevation of intracellular reactive oxygen species and Ca2+ productions and caspase-3 activation.	Capsaicin	0-9	caspase 3	Homo sapiens	195-204
16942782-6	2006	Capsaicin induced G0-G1 phase arrest underwent the promotion of p53 and p21, which is an inhibitor of Cdk2 and cyclin E complex before leading to the inhibitions of both compounds.	Capsaicin	0-9	tumor protein p53	Homo sapiens	64-67
16942782-6	2006	Capsaicin induced G0-G1 phase arrest underwent the promotion of p53 and p21, which is an inhibitor of Cdk2 and cyclin E complex before leading to the inhibitions of both compounds.	Capsaicin	0-9	H3 histone pseudogene 16	Homo sapiens	72-75
16942782-6	2006	Capsaicin induced G0-G1 phase arrest underwent the promotion of p53 and p21, which is an inhibitor of Cdk2 and cyclin E complex before leading to the inhibitions of both compounds.	Capsaicin	0-9	cyclin dependent kinase 2	Homo sapiens	102-106
16942782-9	2006	Collectively, these results suggest that the capsaicin-induced apoptosis in the CE 81T/VGH cells may result from the activation of caspase-3 and intracellular Ca2+ release pathway, and it is further suggested that capsaicin has potential as a novel therapeutic agent for the treatment of esophagus epidermoid carcinoma cells.	Capsaicin	45-54	caspase 3	Homo sapiens	131-140
16781708-2	2006	TRPV1Rs respond to a variety of noxious stimuli including capsaicin, intense heat and acid.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
16957598-4	2006	Conversely, the TRPV1 agonist capsaicin caused an increase in miniature excitatory postsynaptic currents in neurons in the superficial but not deep laminae.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	16-21
16967049-8	2006	mS100A9p inhibited calcium mobilization in DRG neurons in response to the PAR2 agonists trypsin and SLIGRL-NH2, but also in response to capsaicin and bradykinin, suggesting a direct effect of mS100A9 on sensory neurons.	Capsaicin	136-145	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	0-8
16967049-8	2006	mS100A9p inhibited calcium mobilization in DRG neurons in response to the PAR2 agonists trypsin and SLIGRL-NH2, but also in response to capsaicin and bradykinin, suggesting a direct effect of mS100A9 on sensory neurons.	Capsaicin	136-145	S100 calcium binding protein A9 (calgranulin B)	Mus musculus	0-7
16956363-8	2006	Dietary curcumin and capsaicin significantly decreased the activity of 5"-lipoxygenase activity in the polymorphonuclear lymphocytes in carrageenan-injected rats, the decrease being even higher in the case of combination of these two spice principles.	Capsaicin	21-30	arachidonate 5-lipoxygenase	Rattus norvegicus	71-86
16982866-3	2006	Furthermore, exposure of these cells to TRPV1 agonists, capsaicin (CAP) and resiniferatoxin (RTX), triggered cell death.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	40-45
16982866-3	2006	Furthermore, exposure of these cells to TRPV1 agonists, capsaicin (CAP) and resiniferatoxin (RTX), triggered cell death.	Capsaicin	67-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	40-45
16982866-6	2006	Treatment of cells with CAP or RTX led to increased mitochondrial cytochrome c release and enhanced immunoreactivity to cleaved caspase-3.	Capsaicin	24-27	caspase 3	Rattus norvegicus	128-137
16837561-0	2006	Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.	Capsaicin	131-140	glutamate ionotropic receptor kainate type subunit 5	Rattus norvegicus	68-73
16837561-0	2006	Antiallodynic and antihyperalgesic effects of selective competitive GLUK5 (GluR5) ionotropic glutamate receptor antagonists in the capsaicin and carrageenan models in rats.	Capsaicin	131-140	glutamate ionotropic receptor kainate type subunit 1	Rattus norvegicus	75-80
16844842-1	2006	Transient receptor potential vanilloid type 1 (TRPV1) can be activated by multiple chemical and physical stimuli such as capsaicin, anandamide, protons, and heat.	Capsaicin	121-130	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-45
16844842-1	2006	Transient receptor potential vanilloid type 1 (TRPV1) can be activated by multiple chemical and physical stimuli such as capsaicin, anandamide, protons, and heat.	Capsaicin	121-130	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
16844842-2	2006	Capsaicin interacts with the binding pocket constituted by transmembrane regions 3 and 4, whereas protons act through residues in the prepore loop of TRPV1.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	150-155
16844842-4	2006	A rabbit anti-rat TRPV1 polyclonal antibody (Ab-156H) acted as a full antagonist of proton activation (IC(50) values for pH 5 and 5.5 were 364.68 +/- 29.78 and 28.31 +/- 6.30 nM, respectively) and as a partial antagonist of capsaicin, heat, and pH 6 potentiated chemical ligand (anandamide and capsaicin) activation (50-79% inhibition).	Capsaicin	224-233	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
16844842-4	2006	A rabbit anti-rat TRPV1 polyclonal antibody (Ab-156H) acted as a full antagonist of proton activation (IC(50) values for pH 5 and 5.5 were 364.68 +/- 29.78 and 28.31 +/- 6.30 nM, respectively) and as a partial antagonist of capsaicin, heat, and pH 6 potentiated chemical ligand (anandamide and capsaicin) activation (50-79% inhibition).	Capsaicin	294-303	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
16953190-1	2006	BACKGROUND AND PURPOSE: Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation; somatostatin exerts systemic anti-inflammatory actions presumably via sst4/sst1 receptors.	Capsaicin	98-107	calcitonin-related polypeptide alpha	Rattus norvegicus	45-76
16953190-1	2006	BACKGROUND AND PURPOSE: Substance P (SP) and calcitonin gene-related peptide (CGRP) released from capsaicin-sensitive sensory nerves induce local neurogenic inflammation; somatostatin exerts systemic anti-inflammatory actions presumably via sst4/sst1 receptors.	Capsaicin	98-107	calcitonin-related polypeptide alpha	Rattus norvegicus	78-82
16982866-8	2006	In vivo, we also found that intranigral injection of CAP or 12-hydroperoxyeicosatetraenoic acid, an endogenous agonist of TRPV1, into the rat brain produced microglial damage via TRPV1 in the substantia nigra, as visualized by immunocytochemistry.	Capsaicin	53-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	122-127
16982866-8	2006	In vivo, we also found that intranigral injection of CAP or 12-hydroperoxyeicosatetraenoic acid, an endogenous agonist of TRPV1, into the rat brain produced microglial damage via TRPV1 in the substantia nigra, as visualized by immunocytochemistry.	Capsaicin	53-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	179-184
16868036-7	2006	The protective and hyperemic activities of ghrelin were significantly attenuated in rats pretreated with d-Lys(3)-GHRP-6 and capsaicin denervation and completely abolished by vagotomy.	Capsaicin	125-134	ghrelin and obestatin prepropeptide	Rattus norvegicus	43-50
16840565-4	2006	Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves.	Capsaicin	11-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-105
16840565-4	2006	Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves.	Capsaicin	316-325	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-105
16840565-4	2006	Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves.	Capsaicin	11-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
16840565-4	2006	Large dose capsaicin pretreatment to induce degeneration of transient receptor potential vanilloid type-1 (TRPV1)-expressing C fibers greatly reduced, but did not abolish, the sensory irritation response to ATP aerosol and was without effect on the response to adenosine aerosol, indicating that ATP acts largely on capsaicin-sensitive (primarily C fibers) and adenosine acts on capsaicin-insensitive (primarily Adelta fibers) nerves.	Capsaicin	316-325	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-105
16988037-8	2006	Capsaicin also increased the frequency of glutamatergic postsynaptic currents in a VR1-mediated manner.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-86
16597917-3	2006	As shown by fura-2 ratio measurements while cells were incubated in a temperature-regulated chamber, significant [Ca(2+)](cyt) elevation was elicited by rapid changes in bath temperature, application of TRPV1 receptor agonists capsaicin and resiniferatoxin, or a cold receptor stimulator, icilin.	Capsaicin	227-236	transient receptor potential cation channel subfamily V member 1	Homo sapiens	203-208
16971522-1	2006	Vanilloid receptor type 1 (TRPV1) is a ligand-gated nonselective cation channel that is considered to be an important integrator of various pain stimuli such as endogenous lipids, capsaicin, heat, and low pH.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
16955665-8	2006	Regarding the paradox in mice treated with capsaicin as neonates, our explanation is that although capsaicin probably reduces the number of a subgroup of small neurons (IB4-, VR1+), the remaining IB4+ (VR1-) neurons can sense noxious heat normally.	Capsaicin	99-108	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	175-178
16880765-13	2006	CONCLUSIONS AND IMPLICATIONS: Our results suggest that the inhibition produced by donitriptan of capsaicin-induced external carotid vasodilatation is mainly mediated by 5-HT(1B), rather than 5-HT(1D), receptors, probably by a central mechanism.	Capsaicin	97-106	5-hydroxytryptamine receptor 1B	Canis lupus familiaris	169-176
16847435-5	2006	Blockade of capsaicin-sensitive primary afferents (CSPA), nitric oxide (NO)-synthase or guanylate cyclase reduced the PACAP 38 relaxations but failed to modify the VIP responses.	Capsaicin	12-21	adenylate cyclase activating polypeptide 1	Sus scrofa	118-123
16880765-13	2006	CONCLUSIONS AND IMPLICATIONS: Our results suggest that the inhibition produced by donitriptan of capsaicin-induced external carotid vasodilatation is mainly mediated by 5-HT(1B), rather than 5-HT(1D), receptors, probably by a central mechanism.	Capsaicin	97-106	5-hydroxytryptamine receptor 1D	Canis lupus familiaris	191-198
16793902-2	2006	PAR2-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (TRPV1), which is gated by capsaicin, protons and noxious heat.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-111
16831854-3	2006	Capsaicin-, menthol-, and mustard oil-sensitive receptors are TRPV1, TRPM8, and TRPA1, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-67
16831854-3	2006	Capsaicin-, menthol-, and mustard oil-sensitive receptors are TRPV1, TRPM8, and TRPA1, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	69-74
16831854-3	2006	Capsaicin-, menthol-, and mustard oil-sensitive receptors are TRPV1, TRPM8, and TRPA1, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	80-85
17153968-1	2006	Transient receptor potential vanilloid (TRPV1), representing ion channel family, is activated in human and animal organism by capsaicin and some other factors such as heat, acidosis, and ion dysbalance.	Capsaicin	126-135	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
16793902-2	2006	PAR2-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (TRPV1), which is gated by capsaicin, protons and noxious heat.	Capsaicin	139-148	F2R like trypsin receptor 1	Homo sapiens	0-4
16793902-2	2006	PAR2-induced thermal hyperalgesia depends on sensitization of transient receptor potential vanilloid receptor 1 (TRPV1), which is gated by capsaicin, protons and noxious heat.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-118
16793902-7	2006	PAR2 agonists enhanced capsaicin-stimulated increases in [Ca2+]i and whole-cell currents in HEK 293 cells, indicating TRPV1 sensitization.	Capsaicin	23-32	F2R like trypsin receptor 1	Homo sapiens	0-4
16793902-7	2006	PAR2 agonists enhanced capsaicin-stimulated increases in [Ca2+]i and whole-cell currents in HEK 293 cells, indicating TRPV1 sensitization.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
16806299-5	2006	In normal rats, the TRPV1 agonist capsaicin (1 mg/kg) or the FAAH inhibitor URB597 (10 mg/kg) caused a significant reduction in movement in both the horizontal (locomotion) and vertical (rearing) planes (-45% and -53% respectively with capsaicin; -33% and -37% for URB597).	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	20-25
16714086-0	2006	Attenuation of capsaicin-evoked mechanical allodynia by peripheral neuropeptide Y Y1 receptors.	Capsaicin	15-24	neuropeptide Y	Rattus norvegicus	67-81
16714086-2	2006	In particular, previous studies have demonstrated that the Y1 subtype of NPY receptors inhibits nociceptive transmission from capsaicin-sensitive terminals in the dorsal horn of the spinal cord.	Capsaicin	126-135	neuropeptide Y	Rattus norvegicus	73-76
16714086-4	2006	Treatment with the Y1 agonist [Leu31,Pro34]-NPY (0.5, 1, or 10 nmol) significantly inhibited capsaicin-evoked mechanical allodynia in a dose-dependent manner.	Capsaicin	93-102	neuropeptide Y	Rattus norvegicus	44-47
16714086-7	2006	In isolated skin, application of [Leu31,Pro34]-NPY (300 nM) significantly inhibited capsaicin-evoked CGRP release.	Capsaicin	84-93	neuropeptide Y	Rattus norvegicus	47-50
16835009-3	2006	The aim of this study was to determine how the noxious stimulant capsaicin affects intracellular dynamics in the dlPAG evidenced by Fos protein immunoreactivity (index of intracellular activation) and the NADPH-d reactivity.	Capsaicin	65-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	132-135
16835009-5	2006	Compared to vehicle, capsaicin (50mg/kg, subcutaneous) significantly increased NADPH-d reactivity and Fos expression along the dlPAG neuraxis.	Capsaicin	21-30	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	102-105
16835009-6	2006	However, less than one percent of the capsaicin-induced Fos activation occurred in NADPH-d-positive cells.	Capsaicin	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
16996122-3	2006	Ipsilateral, but not contralateral, hindpaw injection of M617 reduced capsaicin (CAP)-induced flinching by approximately 50%, suggesting that GalR1 activation produces anti-nociception.	Capsaicin	70-79	galanin receptor 1	Homo sapiens	142-147
17290875-0	2006	[Alternative changes of activity of alpha2-macroglobulin and alpha1-antitrypsin in rat blood following damage in capsaicin-sensitive nerves].	Capsaicin	113-122	alpha-2-macroglobulin	Rattus norvegicus	36-56
17290875-2	2006	The present results indicate alternative changes in activity of these proteinase inhibitors after damage of capsaicin-sensitive nerves: increasing decline in activity of alpha1-AT 1 and 3 or 14 days after administration of capsaicin and increase in activity of alpha2-MG land 3 day after the injection.	Capsaicin	108-117	alpha-2-macroglobulin	Rattus norvegicus	261-270
16806299-5	2006	In normal rats, the TRPV1 agonist capsaicin (1 mg/kg) or the FAAH inhibitor URB597 (10 mg/kg) caused a significant reduction in movement in both the horizontal (locomotion) and vertical (rearing) planes (-45% and -53% respectively with capsaicin; -33% and -37% for URB597).	Capsaicin	236-245	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	20-25
16806299-5	2006	In normal rats, the TRPV1 agonist capsaicin (1 mg/kg) or the FAAH inhibitor URB597 (10 mg/kg) caused a significant reduction in movement in both the horizontal (locomotion) and vertical (rearing) planes (-45% and -53% respectively with capsaicin; -33% and -37% for URB597).	Capsaicin	236-245	fatty-acid amide hydrolase-like	Rattus norvegicus	61-65
16806299-6	2006	Capsaicin-induced hypolocomotion was attenuated by the TRPV1 antagonist, capsazepine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-60
16854383-7	2006	Mechanical and cold responses increased significantly in C1/C2 but not Vi/Vc neurons following capsaicin.	Capsaicin	95-104	complement C2	Rattus norvegicus	57-62
16914685-3	2006	Analysis of capsaicin-evoked Ca2+ transients in dissociated mouse dorsal root ganglion (DRG) neurons revealed that a 7 min exposure to GDNF, neurturin, or artemin potentiated TRPV1 function at doses 10-100 times lower than NGF.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	175-180
16914685-1	2006	Nerve growth factor (NGF) has been implicated as an effector of inflammatory pain because it sensitizes primary afferents to noxious thermal, mechanical, and chemical [e.g., capsaicin, a transient receptor potential vanilloid receptor 1 (TRPV1) agonist] stimuli and because NGF levels increase during inflammation.	Capsaicin	174-183	nerve growth factor	Mus musculus	0-19
16914685-3	2006	Analysis of capsaicin-evoked Ca2+ transients in dissociated mouse dorsal root ganglion (DRG) neurons revealed that a 7 min exposure to GDNF, neurturin, or artemin potentiated TRPV1 function at doses 10-100 times lower than NGF.	Capsaicin	12-21	neurturin	Mus musculus	141-150
16914685-4	2006	Moreover, GDNF family members induced capsaicin responses in a subset of neurons that were previously insensitive to capsaicin.	Capsaicin	38-47	glial cell line derived neurotrophic factor	Mus musculus	10-14
16914685-1	2006	Nerve growth factor (NGF) has been implicated as an effector of inflammatory pain because it sensitizes primary afferents to noxious thermal, mechanical, and chemical [e.g., capsaicin, a transient receptor potential vanilloid receptor 1 (TRPV1) agonist] stimuli and because NGF levels increase during inflammation.	Capsaicin	174-183	nerve growth factor	Mus musculus	21-24
16914685-4	2006	Moreover, GDNF family members induced capsaicin responses in a subset of neurons that were previously insensitive to capsaicin.	Capsaicin	117-126	glial cell line derived neurotrophic factor	Mus musculus	10-14
16914685-1	2006	Nerve growth factor (NGF) has been implicated as an effector of inflammatory pain because it sensitizes primary afferents to noxious thermal, mechanical, and chemical [e.g., capsaicin, a transient receptor potential vanilloid receptor 1 (TRPV1) agonist] stimuli and because NGF levels increase during inflammation.	Capsaicin	174-183	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	238-243
16914685-1	2006	Nerve growth factor (NGF) has been implicated as an effector of inflammatory pain because it sensitizes primary afferents to noxious thermal, mechanical, and chemical [e.g., capsaicin, a transient receptor potential vanilloid receptor 1 (TRPV1) agonist] stimuli and because NGF levels increase during inflammation.	Capsaicin	174-183	nerve growth factor	Mus musculus	274-277
16914685-3	2006	Analysis of capsaicin-evoked Ca2+ transients in dissociated mouse dorsal root ganglion (DRG) neurons revealed that a 7 min exposure to GDNF, neurturin, or artemin potentiated TRPV1 function at doses 10-100 times lower than NGF.	Capsaicin	12-21	glial cell line derived neurotrophic factor	Mus musculus	135-139
16740613-1	2006	Our previous studies found that nerve growth factor (NGF), via ceramide, enhanced the number of action potentials (APs) evoked by a ramp of depolarizing current in capsaicin-sensitive sensory neurons.	Capsaicin	164-173	nerve growth factor	Rattus norvegicus	32-51
16725275-0	2006	Expression of TWIK-related acid sensitive K+ channels in capsaicin sensitive and insensitive cells of rat dorsal root ganglia.	Capsaicin	57-66	potassium two pore domain channel subfamily K member 1	Rattus norvegicus	14-18
16740613-1	2006	Our previous studies found that nerve growth factor (NGF), via ceramide, enhanced the number of action potentials (APs) evoked by a ramp of depolarizing current in capsaicin-sensitive sensory neurons.	Capsaicin	164-173	nerve growth factor	Rattus norvegicus	53-56
16885226-9	2006	PRL pretreatment significantly enhanced capsaicin-evoked inward currents, calcium influx, and immunoreactive calcitonin gene-related peptide release from cultured TG neurons.	Capsaicin	40-49	prolactin	Rattus norvegicus	0-3
16777323-4	2006	Treatment of rats with NGF over a 13-day period produced a significant increase in capsaicin-evoked iCGRP release from isolated biopsies of hindpaw skin, as assessed by in vitro superfusion and RIA.	Capsaicin	83-92	nerve growth factor	Mus musculus	23-26
16777323-6	2006	This NGF enhancement of capsaicin-evoked iCGRP release was not due solely to increases in peripheral iCGRP content since only the 1mg/kg dose of NGF elevated cutaneous pools of iCGRP, whereas both doses significantly increased capsaicin-evoked peptide release.	Capsaicin	24-33	nerve growth factor	Mus musculus	5-8
16777323-6	2006	This NGF enhancement of capsaicin-evoked iCGRP release was not due solely to increases in peripheral iCGRP content since only the 1mg/kg dose of NGF elevated cutaneous pools of iCGRP, whereas both doses significantly increased capsaicin-evoked peptide release.	Capsaicin	24-33	nerve growth factor	Mus musculus	145-148
16777323-6	2006	This NGF enhancement of capsaicin-evoked iCGRP release was not due solely to increases in peripheral iCGRP content since only the 1mg/kg dose of NGF elevated cutaneous pools of iCGRP, whereas both doses significantly increased capsaicin-evoked peptide release.	Capsaicin	227-236	nerve growth factor	Mus musculus	5-8
16777323-7	2006	Moreover, NGF also enhanced capsaicin-evoked thermal hyperalgesia under similar dose- and time-related conditions.	Capsaicin	28-37	nerve growth factor	Mus musculus	10-13
16777323-8	2006	Collectively, the chronic administration of NGF not only increases capsaicin-evoked hyperalgesia, but also significantly primes peripheral fibers to enhanced peptidergic exocytosis following activation of the capsaicin receptor.	Capsaicin	67-76	nerve growth factor	Mus musculus	44-47
16678970-8	2006	Calmodulin antagonists (ophiobolin-A and calmodulin inhibitory peptide) largely blocked the effect of olvanil and capsaicin on voltage-activated Ca(2+) channel current.	Capsaicin	114-123	calmodulin 1	Rattus norvegicus	0-10
16678970-8	2006	Calmodulin antagonists (ophiobolin-A and calmodulin inhibitory peptide) largely blocked the effect of olvanil and capsaicin on voltage-activated Ca(2+) channel current.	Capsaicin	114-123	calmodulin 1	Rattus norvegicus	41-51
16885226-10	2006	This PRL modulation of capsaicin responses was abolished by withdrawal of E2 from TG cultures.	Capsaicin	23-32	prolactin	Rattus norvegicus	5-8
16885226-12	2006	In a behavioral test, PRL pretreatment significantly potentiated capsaicin-evoked nocifensive behavior in female rats at proestrous and in OVX rats after E2 treatment.	Capsaicin	65-74	prolactin	Rattus norvegicus	22-25
16885226-13	2006	The in vivo potentiating effect of PRL on capsaicin responses was also dependent on E2.	Capsaicin	42-51	prolactin	Rattus norvegicus	35-38
16926503-4	2006	The effectiveness of (+/-)-capsaicinol in TRPV1 activation (EC(50)=1.1 microM) was found to be weaker than that of capsaicin (EC(50)=0.017 microM), whereas the efficacy of (+/-)-capsaicinol reached 75% of that of capsaicin.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
16914432-1	2006	Experiments carried out in conscious guinea pigs suggest that citric acid-evoked coughing is partly mediated by transient receptor potential vanilloid type 1 (TRPV1) receptor-dependent activation of tachykinin-containing, capsaicin-sensitive C fibers.	Capsaicin	222-231	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	112-157
16914432-1	2006	Experiments carried out in conscious guinea pigs suggest that citric acid-evoked coughing is partly mediated by transient receptor potential vanilloid type 1 (TRPV1) receptor-dependent activation of tachykinin-containing, capsaicin-sensitive C fibers.	Capsaicin	222-231	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	159-164
16926503-7	2006	The relative pungency of capsaicinol to capsaicin was coincident with the relative effectiveness in inducing these TRPV1-related actions.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	115-120
16627674-3	2006	Irritant agents, including capsaicin, resiniferatoxin, and citric acid, elicit cough in humans and in experimental animals through the activation of the transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-193
16988918-1	2006	The vanilloid receptor (VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid and high temperature.	Capsaicin	93-102	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-27
16988918-2	2006	VR1 protein functions both as a receptor for capsaicin and a transducer of noxious thermal stimuli.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-3
16988918-4	2006	VR1 is also expressed in a capsaicin-sensitive and peptide-containing sub-population of primary sensory nerves.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-3
16627682-7	2006	We concluded that 1) the initial bradypneic response to H2O2 results from activation of both TRPV1 and P2X receptors, possibly located at terminals of vagal lung capsaicin-sensitive afferent fibers; 2) the functioning of the TRPV1 and P2X receptors in triggering the initial bradypnea is, in part, mediated through the actions of cyclooxygenase metabolites and ATP, respectively; and 3) these mechanisms do not contribute to the H2O2-evoked delayed tachypnea.	Capsaicin	162-171	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	93-98
16627674-3	2006	Irritant agents, including capsaicin, resiniferatoxin, and citric acid, elicit cough in humans and in experimental animals through the activation of the transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	195-200
16842630-0	2006	The mu opioid agonist morphine modulates potentiation of capsaicin-evoked TRPV1 responses through a cyclic AMP-dependent protein kinase A pathway.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
16709636-2	2006	In anaesthetized, spontaneously breathing rats, intratracheal instillation of trypsin (0.8 mg ml(-1), 0.1 ml), an endogenous agonist of PAR2, significantly amplified the capsaicin-induced pulmonary chemoreflex responses.	Capsaicin	170-179	F2R like trypsin receptor 1	Rattus norvegicus	136-140
16849427-3	2006	We tested the hypothesis that certain cannabinoids directly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizing transient receptor potential vanilloid 1 (TRPV1) via a calcium calcineurin-dependent mechanism.	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	158-198
16849427-3	2006	We tested the hypothesis that certain cannabinoids directly inhibit peripheral capsaicin-sensitive nociceptive neurons by dephosphorylating and desensitizing transient receptor potential vanilloid 1 (TRPV1) via a calcium calcineurin-dependent mechanism.	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	200-205
16849427-7	2006	The WIN-induced desensitization of TRPV1 was mediated by calcineurin, because the application of structurally distinct calcineurin antagonists (calcineurin autoinhibitory peptide and cyclosporine/cyclophilin complex) abolished WIN-induced inhibition of capsaicin-evoked inward currents and neuropeptide exocytosis.	Capsaicin	253-262	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-40
16842630-2	2006	Several receptors including G-protein coupled prostaglandin receptors have been reported to functionally interact with the TRPV1 through a cAMP-dependent protein kinase A (PKA) pathway to potentiate TRPV1-mediated capsaicin responses.	Capsaicin	214-223	transient receptor potential cation channel subfamily V member 1	Homo sapiens	123-128
16842630-2	2006	Several receptors including G-protein coupled prostaglandin receptors have been reported to functionally interact with the TRPV1 through a cAMP-dependent protein kinase A (PKA) pathway to potentiate TRPV1-mediated capsaicin responses.	Capsaicin	214-223	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
16842630-5	2006	RESULTS: In the present studies we investigated the hypothesis that the mu opioid receptor (MOP) agonist morphine can modulate forskolin-potentiated capsaicin responses through a cAMP-dependent PKA pathway.	Capsaicin	149-158	opioid receptor mu 1	Homo sapiens	72-90
16842630-5	2006	RESULTS: In the present studies we investigated the hypothesis that the mu opioid receptor (MOP) agonist morphine can modulate forskolin-potentiated capsaicin responses through a cAMP-dependent PKA pathway.	Capsaicin	149-158	opioid receptor mu 1	Homo sapiens	92-95
16842630-6	2006	HEK293 cells were stably transfected with TRPV1 and MOP, and calcium (Ca2+) responses to injection of the TRPV1 agonist capsaicin were monitored in Fluo-3-loaded cells.	Capsaicin	120-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	106-111
16800863-3	2006	We found that MCD significantly reduced TRPV1-mediated capsaicin- and proton-activated currents.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	40-45
16644120-10	2006	PAR2 agonists caused delayed facilitation of sensitivity to capsaicin.	Capsaicin	60-69	pulmonary adenoma resistance 2	Mus musculus	0-4
18615143-3	2006	Bv8 elicits a dose-dependent reduction in nociceptive threshold to thermal and mechanical stimuli applied to the skin of tail and paw of rats and mice and increases the sensitivity to nociceptive mediators as capsaicin and prostaglandins.	Capsaicin	209-218	prokineticin 2	Rattus norvegicus	0-3
18615143-5	2006	In mouse and rat dorsal root ganglia, PKR-expressing neurons also express TRPV1 and the activation of PKRs sensitises TPRV1 to the action of capsaicin.	Capsaicin	141-150	eukaryotic translation initiation factor 2-alpha kinase 2	Rattus norvegicus	38-41
18615143-6	2006	Mice lacking PKR1 gene exhibit impaired Bv8-induced hyperalgesia, develop deficient responses to noxious heat, capsaicin and protons and show reduced thermal and mechanical hypersensitivity to paw inflammation, indicating a requirement for PKR1 signalling associated with activation and sensitisation of primary afferent fibres.	Capsaicin	111-120	prokineticin receptor 1	Mus musculus	13-17
18615146-2	2006	The heat- and capsaicin-gated channel TRPV1, which is an important detector of multiple noxious stimuli, plays a critical role in the development of thermal hyperalgesia induced by a wide range of inflammatory mediators.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	38-43
16753446-11	2006	CONCLUSIONS: These results indicate that nicotinic acetylcholine receptor activation in capsaicin sensitive C-fiber afferents in the bladder can induce detrusor overactivity.	Capsaicin	88-97	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	41-73
16489436-8	2006	In all participants, R2 responses and the intensity of the pain evoked by the electrical stimulus were decreased during and after application of capsaicin compared with baseline (P<0.001).	Capsaicin	145-154	ribonucleotide reductase regulatory subunit M2	Homo sapiens	21-23
16814688-6	2006	beta-Endorphin significantly inhibited calcium responses to 300 nmol/L capsaicin at the lowest experimental extracellular pH (6.1, 6.5, and 7.2), whereas morphine inhibited capsaicin (300 nmol/L) responses significantly at pH 6.1 with a trend of inhibition at pH 6.5.	Capsaicin	71-80	proopiomelanocortin	Homo sapiens	0-14
16814689-5	2006	The destruction of capsaicin-sensitive primary afferents by resiniferatoxin (RTX) pretreatment selectively decreased BV-induced spinal Fos expression but did not affect BV-induced antinociception.	Capsaicin	19-28	FBJ osteosarcoma oncogene	Mus musculus	135-138
16721555-1	2006	The transient receptor potential vanilloid subfamily 1 (TRPV1) is an ion channel activated by capsaicin, heat, protons and endogenous ligands such as anandamide.	Capsaicin	94-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-54
16721555-1	2006	The transient receptor potential vanilloid subfamily 1 (TRPV1) is an ion channel activated by capsaicin, heat, protons and endogenous ligands such as anandamide.	Capsaicin	94-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
16793879-4	2006	When compared with wild-type littermates, mice lacking the pkr1 gene showed impaired responsiveness to noxious heat, mechanical stimuli, capsaicin, and protons.	Capsaicin	137-146	prokineticin receptor 1	Mus musculus	59-63
16595689-5	2006	Capsaicin (a TRPV1 agonist), menthol (a TRPM8 agonist), and icilin (a TRPM8 and TRPA1 agonist) increased intracellular calcium and evoked cationic currents in subsets of neurons, as did the appropriate temperature changes (>43 degrees , <25 degrees , and <17 degrees C, respectively).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
16595689-5	2006	Capsaicin (a TRPV1 agonist), menthol (a TRPM8 agonist), and icilin (a TRPM8 and TRPA1 agonist) increased intracellular calcium and evoked cationic currents in subsets of neurons, as did the appropriate temperature changes (>43 degrees , <25 degrees , and <17 degrees C, respectively).	Capsaicin	0-9	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	40-45
16595689-5	2006	Capsaicin (a TRPV1 agonist), menthol (a TRPM8 agonist), and icilin (a TRPM8 and TRPA1 agonist) increased intracellular calcium and evoked cationic currents in subsets of neurons, as did the appropriate temperature changes (>43 degrees , <25 degrees , and <17 degrees C, respectively).	Capsaicin	0-9	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	70-75
16595689-5	2006	Capsaicin (a TRPV1 agonist), menthol (a TRPM8 agonist), and icilin (a TRPM8 and TRPA1 agonist) increased intracellular calcium and evoked cationic currents in subsets of neurons, as did the appropriate temperature changes (>43 degrees , <25 degrees , and <17 degrees C, respectively).	Capsaicin	0-9	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	80-85
16564619-2	2006	Using Ca2+-imaging, we have previously shown that desensitization of TRPV1 upon successive capsaicin applications was reversed by protein kinase C activation in dorsal root ganglion neurons and CHO cells.	Capsaicin	91-100	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	69-74
16725114-2	2006	Here we show that vanilloid receptor (TRPV1) stimulation with capsaicin and activation of TRPA1 with allyl isothiocyanate or cinnamaldehyde cause a graded contraction of the rat urinary bladder in vitro.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	38-43
16725114-4	2006	Moreover, contraction caused by TRPA1 agonists generates cross-desensitization with capsaicin.	Capsaicin	84-93	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	32-37
16725114-6	2006	The selective TRPV1 receptor antagonist SB 366791 (10 microM) blocks capsaicin-induced contraction, but partially reduces allyl isothiocyanate- or cinnamaldehyde-mediated contraction.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
16793879-5	2006	In wild-type mice, activation of PKRs by the PKR agonist Bv8 caused hyperalgesia and sensitized to the actions of capsaicin.	Capsaicin	114-123	eukaryotic translation initiation factor 2-alpha kinase 2	Mus musculus	33-36
16793879-10	2006	Furthermore, Bv8-responsive neurons from pkr1-null mice showed a significant reduction in the [Ca2+]i response to capsaicin.	Capsaicin	114-123	prokineticin receptor 1	Mus musculus	41-45
16580144-8	2006	In contrast, the proportion of neurons responding to capsaicin significantly decreased in the injured ipsilateral L5-6 dorsal root ganglion cells.	Capsaicin	53-62	HtrA serine peptidase 1	Homo sapiens	114-118
16763024-10	2006	Capsaicin-sensitive TRPV1 vanilloid receptors were not upregulated.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
16584841-0	2006	Capsaicin-induced vasoconstriction in the mouse knee joint: a study using TRPV1 knockout mice.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	74-79
16584841-3	2006	However, in the present study we have shown that capsaicin produces a dose-dependent vasoconstrictor effect in the mouse knee joint via Transient Receptor Potential Vanilloid 1 (TRPV1) receptor activation.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	136-176
16584841-3	2006	However, in the present study we have shown that capsaicin produces a dose-dependent vasoconstrictor effect in the mouse knee joint via Transient Receptor Potential Vanilloid 1 (TRPV1) receptor activation.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	178-183
16584841-4	2006	A (125)I-albumin accumulation technique showed that the intravascular volume of capsaicin-treated joints in wild type (WT) mice was significantly reduced compared to TRPV1 knockout mice (p<0.01).	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	166-171
16584841-5	2006	Similarly, a laser Doppler technique showed significantly reduced blood flow in the capsaicin-treated joints of WT compared to TRPV1 knockout mice (p<0.001).	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	127-132
16674925-0	2006	Effects of capsaicin on P-gp function and expression in Caco-2 cells.	Capsaicin	11-20	phosphoglycolate phosphatase	Homo sapiens	24-28
16674925-2	2006	The aim of the present study was to evaluate the chronicity and reversibility of the modulating effect of capsaicin on both the P-gp expression and activity in the Caco-2 cell monolayers.	Capsaicin	106-115	phosphoglycolate phosphatase	Homo sapiens	128-132
16674925-3	2006	Capsaicin at concentrations ranging from 10 to 100 microM, which were found to be non-cytotoxic towards the Caco-2 cells, were observed to inhibit P-gp mediated efflux transport of [3H]-digoxin in the cells.	Capsaicin	0-9	phosphoglycolate phosphatase	Homo sapiens	147-151
16674925-5	2006	In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.	Capsaicin	78-87	phosphoglycolate phosphatase	Homo sapiens	118-122
16674925-5	2006	In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.	Capsaicin	78-87	phosphoglycolate phosphatase	Homo sapiens	169-173
16674925-5	2006	In contrast, longer term (48 and 72 h) co-incubation of the Caco-2 cells with capsaicin (50 and 100 microM) increased P-gp activity through an up-regulation of cellular P-gp protein and MDR1 mRNA levels.	Capsaicin	78-87	ATP binding cassette subfamily B member 1	Homo sapiens	186-190
16674925-7	2006	The induction of P-gp protein and mRNA levels was also influenced by capsaicin concentration and duration of exposure, with higher expression levels, in particular of the mRNA, seen at higher spice concentrations over prolonged period of incubation.	Capsaicin	69-78	phosphoglycolate phosphatase	Homo sapiens	17-21
16674925-8	2006	Our data suggest that caution should be exercised when capsaicin is to be consumed with drugs that are P-gp substrates.	Capsaicin	55-64	phosphoglycolate phosphatase	Homo sapiens	103-107
16580202-3	2006	Pharmacological studies using electrophysiological and FLIPR-Ca2+-based assays showed that compounds such as 8 and 15 were potent antagonists versus the multiple chemical and physical modes of TRPV1 activation (namely capsaicin, acid and noxious heat).	Capsaicin	218-227	transient receptor potential cation channel subfamily V member 1	Homo sapiens	193-198
16675954-3	2006	TREK-1 is highly expressed in small sensory neurons, is present in both peptidergic and nonpeptidergic neurons and is extensively colocalized with TRPV1, the capsaicin-activated nonselective ion channel.	Capsaicin	158-167	potassium channel, subfamily K, member 2	Mus musculus	0-6
16675954-3	2006	TREK-1 is highly expressed in small sensory neurons, is present in both peptidergic and nonpeptidergic neurons and is extensively colocalized with TRPV1, the capsaicin-activated nonselective ion channel.	Capsaicin	158-167	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	147-152
16792172-10	2006	These results suggest that capsaicin can directly influence the epithelial secretory and various functions via TRPV1 as well as the activation of the sensory neurons.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	111-116
16636964-7	2006	These responses to capsaicin were also greatly inhibited by ruthenium red (3 mg/kg, S. C.), a non-competitive capsaicin receptor (TRPV1) antagonist.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	110-128
16636964-7	2006	These responses to capsaicin were also greatly inhibited by ruthenium red (3 mg/kg, S. C.), a non-competitive capsaicin receptor (TRPV1) antagonist.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	130-135
16636964-14	2006	These data suggest that AHAL inhibits acute neurogenic inflammation possibly involving capsaicin-sensitive TRPV1-receptors, endogenous adenosine and ATP-sensitive potassium channels.	Capsaicin	87-96	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
16384857-6	2006	Of the CCK-responsive neurons 60% (18 of 30) were capsaicin-sensitive.	Capsaicin	50-59	cholecystokinin	Homo sapiens	7-10
16384857-10	2006	Of these CCK-responsive neurons 80% (12 of 15) were capsaicin sensitive.	Capsaicin	52-61	cholecystokinin	Homo sapiens	9-12
16384857-11	2006	Leptin activated 46% (13 of 28) of these duodenal innervating neurons, of which 89% (8 of 9) were capsaicin-sensitive.	Capsaicin	98-107	leptin	Homo sapiens	0-6
16741069-0	2006	Endothelin-1 potentiates capsaicin-induced TRPV1 currents via the endothelin A receptor.	Capsaicin	25-34	endothelin 1	Homo sapiens	0-12
16741069-0	2006	Endothelin-1 potentiates capsaicin-induced TRPV1 currents via the endothelin A receptor.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
16741069-3	2006	TRPV1, the heat-, proton-, and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released by painful stimuli and during inflammation, is a potential target for the action of ET-1.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
16741069-3	2006	TRPV1, the heat-, proton-, and capsaicin-sensitive cation channel already known to be modulated by a number of cellular mediators released by painful stimuli and during inflammation, is a potential target for the action of ET-1.	Capsaicin	31-40	endothelin 1	Homo sapiens	223-227
16741069-6	2006	In whole-cell patch clamp recordings of HEK293 cells co-expressing TRPV1-YFP and the ET(A) receptor, capsaicin (10 nM) elicited small currents, which were markedly potentiated when capsaicin (10 nM) and ET-1 (100 nM) were applied simultaneously.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
16741069-6	2006	In whole-cell patch clamp recordings of HEK293 cells co-expressing TRPV1-YFP and the ET(A) receptor, capsaicin (10 nM) elicited small currents, which were markedly potentiated when capsaicin (10 nM) and ET-1 (100 nM) were applied simultaneously.	Capsaicin	101-110	endothelin 1	Homo sapiens	203-207
16718783-9	2006	Capsaicin evoked an increase in [Ca2+]i in rat TRPV1-transfected HEK293 cells while lafutidine did not.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	47-52
16718783-1	2006	AIM: Lafutidine, a histamine H2 receptor antagonist, exhibits gastro-protective action mediated by capsaicin-sensitive afferent neurons (CSN).	Capsaicin	99-108	histamine receptor H 2	Rattus norvegicus	19-40
16718783-10	2006	CONCLUSION: These results suggest that although both lafutidine and capsaicin exhibit gastro-protective action mediated by CSN, the mode of their effects differs regarding the dependency on endogenous PGs/IP receptors and TRPV1.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	222-227
16630609-1	2006	The transient receptor potential vanilloid 1 (TRPV1) receptor is a ligand-gated cation channel that can be activated by capsaicin, heat, protons and cytosolic lipids.	Capsaicin	120-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-44
16515841-4	2006	In cultured dorsal root ganglion neurons, whole cell patch clamp recordings showed that the majority of capsaicin-sensitive rat dorsal root ganglion neurons displayed large proton-evoked inward currents with transient ASIC-like properties.	Capsaicin	104-113	acid-sensing (proton-gated) ion channel 1	Mus musculus	218-222
16515841-5	2006	In contrast, the prevalence of ASIC-like currents was smaller in both mouse wildtype strains and more frequent in capsaicin-insensitive neurons.	Capsaicin	114-123	acid-sensing (proton-gated) ion channel 1	Mus musculus	31-35
16630609-1	2006	The transient receptor potential vanilloid 1 (TRPV1) receptor is a ligand-gated cation channel that can be activated by capsaicin, heat, protons and cytosolic lipids.	Capsaicin	120-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
16399878-5	2006	Injection of the TRPV1 agonist capsaicin into the pancreatic duct induced endocytosis of the neurokinin 1 receptor in spinal neurons in the dorsal horn (T10), indicative of SP release upon stimulation of pancreatic sensory nerves.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	17-22
16687502-4	2006	Bv8 caused increases in [Ca]i in a population of isolated dorsal root ganglion (DRG) neurons, which we identified as nociceptors, or sensors for painful stimuli, from their responses to capsaicin, bradykinin, mustard oil, or proteases.	Capsaicin	186-195	prokineticin 2	Homo sapiens	0-3
16399878-5	2006	Injection of the TRPV1 agonist capsaicin into the pancreatic duct induced endocytosis of the neurokinin 1 receptor in spinal neurons in the dorsal horn (T10), indicative of SP release upon stimulation of pancreatic sensory nerves.	Capsaicin	31-40	tachykinin receptor 1	Rattus norvegicus	93-114
16717036-2	2006	Moreover, based on the highly selective agonism of trans-capsaicin for TRPV1 receptors, drug products containing high concentrations of trans-capsaicin are under development as analgesics.	Capsaicin	51-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	71-76
16616732-4	2006	Furthermore, capsaicin activated more Fos-positive cells than vehicle within all subregions of the DRN but with a caudal versus rostral predominance in activation pattern.	Capsaicin	13-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-41
16616732-5	2006	In addition, a high proportion of capsaicin-induced Fos cells in the midline but almost none in lateral wing stained for NADPH-d.	Capsaicin	34-43	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-55
16616732-8	2006	The total capsaicin-induced galanin immunoreactivity was higher in rostral versus caudal DRN, and a high proportion of galanin-positive cells in the midline also contained NADPH-d and neuronal NOS, thus suggesting a potential NO-galanin interaction in these neurons.	Capsaicin	10-19	nitric oxide synthase 1	Rattus norvegicus	184-196
16626641-2	2006	The role of capsaicin-sensitive afferents in Fos and gastric responses to distension was also investigated.	Capsaicin	12-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-48
16626641-6	2006	Pretreatment with systemic capsaicin prevented both the brain increase in Fos expression and the inhibition of gastric emptying induced by the colon distension.	Capsaicin	27-36	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	74-77
16630076-6	2006	Fibroblasts treated with capsaicin, an agonist to the VR1, induced significant changes of the membrane current and the intracellular calcium level, and these changes were antagonized by capsazepin.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	54-57
16827131-0	2006	Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells.	Capsaicin	49-58	BCL2 associated X, apoptosis regulator	Homo sapiens	15-18
16827131-0	2006	Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells.	Capsaicin	49-58	BCL2 apoptosis regulator	Homo sapiens	20-25
16827131-0	2006	Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells.	Capsaicin	49-58	carbonic anhydrase 2	Homo sapiens	27-30
16827131-0	2006	Involvement of Bax, Bcl-2, Ca2+ and caspase-3 in capsaicin-induced apoptosis of human leukemia HL-60 cells.	Capsaicin	49-58	caspase 3	Homo sapiens	36-45
16827131-3	2006	Capsaicin-induced G0/G1-phase arrest involved the suppression of CDK2 and the cyclin E complex, which are check-point enzymes for cells moving from G0/G1- to S-phase.	Capsaicin	0-9	cyclin dependent kinase 2	Homo sapiens	65-69
16827131-4	2006	Capsaicin-induced apoptosis was associated with the elevation of intracellular reactive oxygen species and Ca2+ production, decreased the levels of mitochondrial membrane potential, promoted cytochrome c release and increased the activation of caspase-3.	Capsaicin	0-9	carbonic anhydrase 2	Homo sapiens	107-110
16827131-4	2006	Capsaicin-induced apoptosis was associated with the elevation of intracellular reactive oxygen species and Ca2+ production, decreased the levels of mitochondrial membrane potential, promoted cytochrome c release and increased the activation of caspase-3.	Capsaicin	0-9	cytochrome c, somatic	Homo sapiens	191-203
16827131-4	2006	Capsaicin-induced apoptosis was associated with the elevation of intracellular reactive oxygen species and Ca2+ production, decreased the levels of mitochondrial membrane potential, promoted cytochrome c release and increased the activation of caspase-3.	Capsaicin	0-9	caspase 3	Homo sapiens	244-253
16827131-5	2006	An intracellular Ca2+ chelator (BAPTA) significantly inhibited capsaicin-induced apoptosis.	Capsaicin	63-72	carbonic anhydrase 2	Homo sapiens	17-20
16827131-7	2006	These results suggest that the capsaicin-induced apoptosis of HL-60 cells may result from the activation of caspase-3 and the intracellular Ca2+ release pathway.	Capsaicin	31-40	caspase 3	Homo sapiens	108-117
16827131-7	2006	These results suggest that the capsaicin-induced apoptosis of HL-60 cells may result from the activation of caspase-3 and the intracellular Ca2+ release pathway.	Capsaicin	31-40	carbonic anhydrase 2	Homo sapiens	140-143
16196077-2	2006	We postulated that treating these resistance vessels with capsaicin would cause the release of endogenous CGRP and vascular relaxation.	Capsaicin	58-67	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
16196077-7	2006	When examining potential candidates for the mediation of capsaicin-induced constriction, we found that vasopressin (VP), NPY, serotonin (5HT) and endothelin (ET), but not neurokinin A or substance P, caused a concentration-dependent vasoconstriction of epineurial arterioles.	Capsaicin	57-66	arginine vasopressin	Rattus norvegicus	103-114
16196077-7	2006	When examining potential candidates for the mediation of capsaicin-induced constriction, we found that vasopressin (VP), NPY, serotonin (5HT) and endothelin (ET), but not neurokinin A or substance P, caused a concentration-dependent vasoconstriction of epineurial arterioles.	Capsaicin	57-66	arginine vasopressin	Rattus norvegicus	116-118
16196077-7	2006	When examining potential candidates for the mediation of capsaicin-induced constriction, we found that vasopressin (VP), NPY, serotonin (5HT) and endothelin (ET), but not neurokinin A or substance P, caused a concentration-dependent vasoconstriction of epineurial arterioles.	Capsaicin	57-66	neuropeptide Y	Rattus norvegicus	121-124
16196077-8	2006	Epineurial arterioles express NPY and receptor antagonists to NPY significantly decreased capsaicin-induced vasoconstriction.	Capsaicin	90-99	neuropeptide Y	Rattus norvegicus	30-33
16196077-8	2006	Epineurial arterioles express NPY and receptor antagonists to NPY significantly decreased capsaicin-induced vasoconstriction.	Capsaicin	90-99	neuropeptide Y	Rattus norvegicus	62-65
16196077-12	2006	CONCLUSIONS: These studies suggest that long-term diabetes causes vascular dysfunction in epineurial arterioles of the sciatic nerve that includes a decrease in capsaicin-induced vasoconstriction that is likely due to a decrease in the expression of vanilloid receptor 1.	Capsaicin	161-170	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	250-270
16717036-2	2006	Moreover, based on the highly selective agonism of trans-capsaicin for TRPV1 receptors, drug products containing high concentrations of trans-capsaicin are under development as analgesics.	Capsaicin	136-151	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	71-76
16434565-4	2006	Apical application of the PAR(2) peptide SLIGRL caused increases in I(SC), which were inhibited by three structurally different neurokinin receptor-1 (NK(1)R) antagonists and inhibitors of Cl(-) channels but not by capsaicin, the calcitonin gene-related peptide (CGRP) receptor antagonist CGRP(8-37), or the nonselective cyclooxygenase inhibitor indomethacin.	Capsaicin	215-224	pulmonary adenoma resistance 2	Mus musculus	26-32
16581065-10	2006	Deactivation of sensory nerves with capsaicin or inhibition of cNOS by L-NNA significantly attenuated the protective activity of ghrelin and accompanying increase in the GBF.	Capsaicin	36-45	ghrelin and obestatin prepropeptide	Rattus norvegicus	129-136
16542883-4	2006	The function of these chemoceptive afferents can selectively be manipulated and explored with the use of capsaicin which acts via a cation channel termed TRPV1.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	154-159
16413055-9	2006	Capsaicin, bradykinin and the potassium solution caused concentration-dependent increases in CGRP release.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	93-97
16608395-7	2006	Vector-forced overexpression of tNOX cDNA and antisense has demonstrated that the tNOX target is both necessary and sufficient to explain the anticancer properties of green tea catechins alone and in vanilloid-containing combinations.	Capsaicin	200-209	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	32-36
16226344-5	2006	On the other hand, co-administration intrathecally with Tyr-D-Pro-Trp-Gly-NH2 (D-Pro2-Tyr-W-MIF-1), a selective mu2-opioid receptor antagonist, significantly attenuated the antinociceptive effects of DAMGO, but not TAPA and TAPA-NH2, against capsaicin, while the antinociceptions induced by three opioid peptides against SP were significantly inhibited by D-Pro2-Tyr-W-MIF-1.	Capsaicin	242-251	predicted gene 4924	Mus musculus	92-97
16608395-7	2006	Vector-forced overexpression of tNOX cDNA and antisense has demonstrated that the tNOX target is both necessary and sufficient to explain the anticancer properties of green tea catechins alone and in vanilloid-containing combinations.	Capsaicin	200-209	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	82-86
16608395-10	2006	A catechin-vanilloid mixture where one 350-mg capsule is equivalent to 16 cups of green tea in its ability to inhibit tNOX and growth of cancer cells in culture is undergoing clinical evaluation as a therapeutic aid for cancer patients.	Capsaicin	11-20	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	118-122
16476579-5	2006	AQP1(-/-) mice had reduced responsiveness to thermal and capsaicin chemical stimuli, but not to mechanical stimuli or formalin.	Capsaicin	57-66	aquaporin 1	Mus musculus	0-4
16566843-1	2006	BACKGROUND: Cultured sensory neurons are a common experimental model to elucidate the molecular mechanisms of pain transduction typically involving activation of ATP-sensitive P2X or capsaicin-sensitive TRPV1 receptors.	Capsaicin	183-192	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	203-208
16540674-0	2006	Capsaicin, a component of red peppers, inhibits the growth of androgen-independent, p53 mutant prostate cancer cells.	Capsaicin	0-9	tumor protein p53	Homo sapiens	84-87
16540674-3	2006	Capsaicin down-regulated the expression of not only prostate-specific antigen (PSA) but also AR.	Capsaicin	0-9	kallikrein related peptidase 3	Homo sapiens	52-83
16540674-3	2006	Capsaicin down-regulated the expression of not only prostate-specific antigen (PSA) but also AR.	Capsaicin	0-9	androgen receptor	Homo sapiens	93-95
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	28-37	kallikrein related peptidase 3	Homo sapiens	99-102
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	28-37	kallikrein related peptidase 3	Homo sapiens	231-234
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	28-37	androgen receptor	Homo sapiens	281-283
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	28-37	kallikrein related peptidase 3	Homo sapiens	231-234
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	190-199	kallikrein related peptidase 3	Homo sapiens	99-102
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	190-199	kallikrein related peptidase 3	Homo sapiens	231-234
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	190-199	androgen receptor	Homo sapiens	281-283
16540674-4	2006	Promoter assays showed that capsaicin inhibited the ability of dihydrotestosterone to activate the PSA promoter/enhancer even in the presence of exogenous AR in LNCaP cells, suggesting that capsaicin inhibited the transcription of PSA not only via down-regulation of expression of AR, but also by a direct inhibitory effect on PSA transcription.	Capsaicin	190-199	kallikrein related peptidase 3	Homo sapiens	231-234
16540674-6	2006	In further studies, capsaicin inhibited tumor necrosis factor-alpha-stimulated degradation of IkappaBalpha in PC-3 cells, which was associated with the inhibition of proteasome activity.	Capsaicin	20-29	tumor necrosis factor	Homo sapiens	40-67
16540674-6	2006	In further studies, capsaicin inhibited tumor necrosis factor-alpha-stimulated degradation of IkappaBalpha in PC-3 cells, which was associated with the inhibition of proteasome activity.	Capsaicin	20-29	NFKB inhibitor alpha	Homo sapiens	94-106
16529650-2	2006	This study aimed to investigate the efficacy of a single, oral dose of the specific COX-2 inhibitor-valdecoxib in attenuating the central sensitization - induced secondary hyperalgesia in a heat/capsaicin pain model in healthy volunteers.	Capsaicin	195-204	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	84-89
16540674-7	2006	Taken together, capsaicin inhibits proteasome activity which suppressed the degradation of IkappaBalpha, preventing the activation of NF-kappaB.	Capsaicin	16-25	NFKB inhibitor alpha	Homo sapiens	91-103
16540674-7	2006	Taken together, capsaicin inhibits proteasome activity which suppressed the degradation of IkappaBalpha, preventing the activation of NF-kappaB.	Capsaicin	16-25	nuclear factor kappa B subunit 1	Homo sapiens	134-143
16365187-4	2006	In contrast, capsaicin (10 or 30 microg/kg), a selective TRPV1 agonist, dose-dependently decreased mean arterial pressure in all of the groups with the most profound magnitude in DR+HS rats compared with the other 3 groups.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
16464449-2	2006	TRPV1 is activated by noxious temperature, low extracellular pH and diverse lipid derivatives, and is uniquely sensitive to vanilloid molecules, including capsaicin.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
16464449-2	2006	TRPV1 is activated by noxious temperature, low extracellular pH and diverse lipid derivatives, and is uniquely sensitive to vanilloid molecules, including capsaicin.	Capsaicin	155-164	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
16553616-12	2006	Both L768242 and (+)-AM1241 dose dependently (EC50 of 3.6 and 4.5 nM, respectively) reduced capsaicin-induced calcitonin gene-related peptide (CGRP) release.	Capsaicin	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	110-141
16553616-12	2006	Both L768242 and (+)-AM1241 dose dependently (EC50 of 3.6 and 4.5 nM, respectively) reduced capsaicin-induced calcitonin gene-related peptide (CGRP) release.	Capsaicin	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	143-147
16553616-14	2006	Experiments on capsaicin-induced CGRP release in tissue from CB1-/- mice ruled out a CB1-mediated effect.	Capsaicin	15-24	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	33-37
16553616-14	2006	Experiments on capsaicin-induced CGRP release in tissue from CB1-/- mice ruled out a CB1-mediated effect.	Capsaicin	15-24	cannabinoid receptor 1 (brain)	Mus musculus	61-64
16319216-2	2006	To better understand such molecular and cellular mechanisms, we investigated how IL-1beta modulates the total voltage-dependent sodium currents (INa) and its tetrodotoxin-resistant (TTX-R) component in capsaicin-sensitive trigeminal nociceptive neurons, both after a brief (5-min) and after a chronic exposure (24-h) of 20 ng/ml IL-1beta.	Capsaicin	202-211	interleukin 1 beta	Homo sapiens	81-89
16338989-4	2006	We found that the TRPV1 agonist capsaicin (1 microM) elicited a substantial constriction in isolated arterioles (51 +/- 12%).	Capsaicin	32-41	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	18-23
16469640-9	2006	Adenosine triphosphate/capsaicin application increased CGRP release by 75% over baseline (606 +/- 98 pg/gm, p < 0.005).	Capsaicin	23-32	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
16510717-5	2006	When expressed heterologously, FAF1 reduces the responses of TRPV1 to capsaicin, acid, and heat, to the pharmacological level of native capsaicin receptor in sensory neurons.	Capsaicin	70-79	Fas associated factor 1	Homo sapiens	31-35
16510717-5	2006	When expressed heterologously, FAF1 reduces the responses of TRPV1 to capsaicin, acid, and heat, to the pharmacological level of native capsaicin receptor in sensory neurons.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
16510717-6	2006	Furthermore, silencing FAF1 by RNA interference augments capsaicin-sensitive current in native sensory neurons.	Capsaicin	57-66	Fas associated factor 1	Homo sapiens	23-27
16716036-6	2006	In addition, capsaicin, which releases endogenous SP from nerve endings, produced depolarizations of a magnitude similar to formalin in strip preparations, but was without effect in cultured cells.	Capsaicin	13-22	tachykinin precursor 1	Homo sapiens	50-52
16407761-4	2006	Single-cell reverse-transcription polymerase chain reaction revealed the expression of TRPV1 only in capsaicin-sensitive neurons.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
16503963-1	2006	In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-132
16503963-1	2006	In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-139
16503963-1	2006	In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods.	Capsaicin	39-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-132
16503963-1	2006	In this study, we show that capsaicin (CAP) depresses primary afferent fiber terminal excitability by acting on vanilloid receptor 1 (TRPV1 channels) of primary afferent fibers in adenosine 5"-triphosphate (ATP)- and temperature-dependent manner using two optical imaging methods.	Capsaicin	39-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-139
16438961-3	2006	The guinea-pigs underwent regional sensory denervation of the anterior hepatic plexus exhibited insulin resistance, whereas systemic capsaicin desensitization increased insulin sensitivity.	Capsaicin	133-142	insulin	Cavia porcellus	169-176
16438961-4	2006	Intraportal administration of L-nitro-arginine methyl ester (L-NAME decreased, whereas capsaicin increased insulin sensitivity.	Capsaicin	87-96	insulin	Cavia porcellus	107-114
16192299-6	2006	The magnitude of membrane depolarization was dependent on leptin concentration and occurred in both capsaicin-sensitive and capsaicin-insensitive neurons.	Capsaicin	100-109	leptin	Rattus norvegicus	58-64
16143644-7	2006	Administration of exogenous CGRP or induction of endogenous CGRP release by treatment with capsaicin 24 h before I/R mimicked the postischemic anti-inflammatory effects of antecedent ethanol ingestion.	Capsaicin	91-100	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	60-64
16143644-8	2006	Preconditioning with capsaicin 24 h before I/R was prevented by coincident treatment with CGRP-(8-37), while exogenous CGRP induced an anti-inflammatory phenotype in mice depleted of CGRP by capsaicin administration 4 days earlier.	Capsaicin	21-30	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	90-94
16143644-8	2006	Preconditioning with capsaicin 24 h before I/R was prevented by coincident treatment with CGRP-(8-37), while exogenous CGRP induced an anti-inflammatory phenotype in mice depleted of CGRP by capsaicin administration 4 days earlier.	Capsaicin	191-200	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	119-123
16143644-8	2006	Preconditioning with capsaicin 24 h before I/R was prevented by coincident treatment with CGRP-(8-37), while exogenous CGRP induced an anti-inflammatory phenotype in mice depleted of CGRP by capsaicin administration 4 days earlier.	Capsaicin	191-200	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	119-123
16192299-6	2006	The magnitude of membrane depolarization was dependent on leptin concentration and occurred in both capsaicin-sensitive and capsaicin-insensitive neurons.	Capsaicin	124-133	leptin	Rattus norvegicus	58-64
16459279-3	2006	Local injections of capsaicin (0.1-30 microg) into the hindpaw produced flinching and biting/licking behaviors over 5 min, and these were reduced by capsazepine, a competitive antagonist for capsaicin at the TRPV1 receptor.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	208-213
16459279-3	2006	Local injections of capsaicin (0.1-30 microg) into the hindpaw produced flinching and biting/licking behaviors over 5 min, and these were reduced by capsazepine, a competitive antagonist for capsaicin at the TRPV1 receptor.	Capsaicin	191-200	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	208-213
16481260-10	2006	Calcitonin gene-related peptide markedly increased cell proliferation in D2 capsaicin pretreated gubernacula compared with controls (25% vs 14%, P < .01) and normal D2 gubernacula cultured with CGRP (P < .01).	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
16409253-0	2006	Capsaicin-induced local elevations in collagenase-2 (matrix metalloproteinase-8) levels in human gingival crevice fluid.	Capsaicin	0-9	matrix metallopeptidase 8	Homo sapiens	38-51
16409253-0	2006	Capsaicin-induced local elevations in collagenase-2 (matrix metalloproteinase-8) levels in human gingival crevice fluid.	Capsaicin	0-9	matrix metallopeptidase 8	Homo sapiens	53-79
16409253-4	2006	With this background, we wished to study whether capsaicin stimulation of alveolar mucosa can induce changes in the GCF MMP-8 levels.	Capsaicin	49-58	matrix metallopeptidase 8	Homo sapiens	120-125
16207832-9	2006	In rTRPV1-expressing CHO cells, they caused a significant rightward shift in the log concentration-response curve for the TRPV1 receptor agonist capsaicin (3-methoxy-4-hydroxy)benzyl-8-methyl-6-nonenamide).	Capsaicin	145-154	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	3-9
16207832-9	2006	In rTRPV1-expressing CHO cells, they caused a significant rightward shift in the log concentration-response curve for the TRPV1 receptor agonist capsaicin (3-methoxy-4-hydroxy)benzyl-8-methyl-6-nonenamide).	Capsaicin	145-154	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	4-9
16409253-8	2006	RESULTS: Capsaicin stimulation of the alveolar mucosa induced significant local elevations in levels and activation of MMP-8 in GCF of the adjacent teeth.	Capsaicin	9-18	matrix metallopeptidase 8	Homo sapiens	119-124
16298080-0	2006	Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons.	Capsaicin	22-31	endothelin 1	Mus musculus	0-12
16409253-10	2006	This capsaicin-evoked MMP-8 elevation lasted several minutes after stimulation.	Capsaicin	5-14	matrix metallopeptidase 8	Homo sapiens	22-27
16409253-12	2006	CONCLUSIONS: These results suggest that capsaicin-evoked neurogenic gingival inflammation can trigger the expression and activation of MMP-8 in GCF of the adjacent teeth.	Capsaicin	40-49	matrix metallopeptidase 8	Homo sapiens	135-140
16298080-0	2006	Endothelin-1 enhances capsaicin-evoked intracellular Ca2+ response via activation of endothelin a receptor in a protein kinase Cepsilon-dependent manner in dorsal root ganglion neurons.	Capsaicin	22-31	endothelin receptor type A	Mus musculus	85-106
16298080-3	2006	The current study investigated the effects of endothelin-1 on the capsaicin-evoked intracellular Ca2+ response of cultured adult mice dorsal root ganglion neurons.	Capsaicin	66-75	endothelin 1	Mus musculus	46-58
16298080-7	2006	Endothelin-1 (10 nM) enhanced an increase in [Ca2+]i by capsaicin (10 nM) from 87.6+/-11.6 nM to 414.8+/-62.3 nM (71 of 156 neurons).	Capsaicin	56-65	endothelin 1	Mus musculus	0-12
16298080-13	2006	Our results indicate that endothelin-1 enhances the response of dorsal root ganglion neurons to capsaicin in a protein kinase Cepsilon-dependent manner.	Capsaicin	96-105	endothelin 1	Mus musculus	26-38
16188279-9	2006	The excitatory component in the PAR-1 and -2 modulation may be mediated, in part, by activation of capsaicin-sensitive sensory nerves and/or endogenous prostaglandin formation.	Capsaicin	99-108	coagulation factor II (thrombin) receptor	Mus musculus	32-44
16360146-1	2006	The mechanisms underlying transient receptor potential vanilloid receptor type 1 (TRPV1)-independent relaxation elicited by capsaicin were studied by measuring isometric force and phosphorylation of 20-kDa regulatory light chain subunit of myosin (MLC(20)) in ileum longitudinal smooth muscles of guinea-pigs.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	82-87
16374544-4	2006	Capsaicin induced apoptosis in prostate cells by a mechanism involving reactive oxygen species generation, dissipation of the mitochondrial inner transmembrane potential (DeltaPsi(m)) and activation of caspase 3.	Capsaicin	0-9	caspase 3	Mus musculus	202-211
16091583-1	2006	The capsaicin receptor and transient receptor potential channel TRPV1 senses heat, protons, and vanilloid agonists in peripheral sensory ganglia.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-69
16213723-1	2006	Intracellular photolysis of a novel "caged" capsaicin analogue results in in vitro activation of the capsaicin receptor TRPV1.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-125
17379941-5	2006	Because the drug-inhibited ECTO-NOX protein, tNOX was utilized, the enlargement was inhibited by capsaicin, a quinone site tNOX inhibitor specific for tNOX.	Capsaicin	97-106	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	45-49
17379941-5	2006	Because the drug-inhibited ECTO-NOX protein, tNOX was utilized, the enlargement was inhibited by capsaicin, a quinone site tNOX inhibitor specific for tNOX.	Capsaicin	97-106	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	123-127
17379941-5	2006	Because the drug-inhibited ECTO-NOX protein, tNOX was utilized, the enlargement was inhibited by capsaicin, a quinone site tNOX inhibitor specific for tNOX.	Capsaicin	97-106	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	123-127
16918352-1	2006	Capsaicin-sensitive sensory neurons are nociceptive neurons that release calcitonin gene-related peptide (CGRP) on activation.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	73-104
16918352-1	2006	Capsaicin-sensitive sensory neurons are nociceptive neurons that release calcitonin gene-related peptide (CGRP) on activation.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	106-110
16918426-2	2006	Release of neurotransmitters such as calcitonin gene-related peptide (CGRP) and the consequent increase in mucosal blood flow have been identified as key factors in the protective effect of the stimulation of these fibers by capsaicin.	Capsaicin	225-234	calcitonin-related polypeptide alpha	Rattus norvegicus	37-68
16918426-2	2006	Release of neurotransmitters such as calcitonin gene-related peptide (CGRP) and the consequent increase in mucosal blood flow have been identified as key factors in the protective effect of the stimulation of these fibers by capsaicin.	Capsaicin	225-234	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74
16918426-9	2006	Taken together, these data suggest that capsaicin-sensitive afferent nerves may play a role in the process of ulcer healing by mediating the hyperemic response through the release of CGRP and facilitating the acid disposal in the mucosa.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	183-187
16373680-3	2006	Immunohistochemical analyses of human and rat trigeminal neurons demonstrated that a capsaicin-sensitive subclass of nociceptors (defined by expression of TRPV1, a capsaicin receptor) expresses both TLR4 and CD14.	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	155-160
16278290-6	2006	This is the first demonstration that gene expression changes in the heart due to capsaicin pretreatment included vanilloid receptor-1 (capsaicin receptor), transient receptor potential protein, GABA receptor rho-3 subunit, 5-hydroxytryptamine 3 receptor B, neurokinin receptor 2, endothelial nitric oxide synthase, matrix metalloproteinase-13, cytochrome P450, farnesyl-transferase, ApoB, and leptin.	Capsaicin	81-90	matrix metallopeptidase 13	Rattus norvegicus	315-342
16278290-6	2006	This is the first demonstration that gene expression changes in the heart due to capsaicin pretreatment included vanilloid receptor-1 (capsaicin receptor), transient receptor potential protein, GABA receptor rho-3 subunit, 5-hydroxytryptamine 3 receptor B, neurokinin receptor 2, endothelial nitric oxide synthase, matrix metalloproteinase-13, cytochrome P450, farnesyl-transferase, ApoB, and leptin.	Capsaicin	81-90	apolipoprotein B	Rattus norvegicus	383-387
16373680-3	2006	Immunohistochemical analyses of human and rat trigeminal neurons demonstrated that a capsaicin-sensitive subclass of nociceptors (defined by expression of TRPV1, a capsaicin receptor) expresses both TLR4 and CD14.	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	164-182
16373680-3	2006	Immunohistochemical analyses of human and rat trigeminal neurons demonstrated that a capsaicin-sensitive subclass of nociceptors (defined by expression of TRPV1, a capsaicin receptor) expresses both TLR4 and CD14.	Capsaicin	85-94	toll-like receptor 4	Rattus norvegicus	199-203
16373680-3	2006	Immunohistochemical analyses of human and rat trigeminal neurons demonstrated that a capsaicin-sensitive subclass of nociceptors (defined by expression of TRPV1, a capsaicin receptor) expresses both TLR4 and CD14.	Capsaicin	85-94	CD14 molecule	Rattus norvegicus	208-212
16373680-5	2006	Collectively, these studies indicate that the capsaicin-sensitive subclass of trigeminal nociceptors expresses TLR4 and CD14.	Capsaicin	46-55	toll like receptor 4	Homo sapiens	111-115
16373680-5	2006	Collectively, these studies indicate that the capsaicin-sensitive subclass of trigeminal nociceptors expresses TLR4 and CD14.	Capsaicin	46-55	CD14 molecule	Homo sapiens	120-124
16328494-4	2006	This suggests that stimulation by capsaicin of TRPV1 receptors on primary afferent fibres causes a release of tachykinins which, in turn, mediate via NK1 and NK3 receptors an increase in acetylcholine release.	Capsaicin	34-43	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	47-52
16328494-9	2006	Desensitization of TRPV1 receptors by a short exposure to 3 microM capsaicin abolished the facilitatory responses to a subsequent administration, but did not modify the inhibitory effects.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	19-24
16298082-6	2006	Measuring immunoreactive substance P and immunoreactive calcitonin gene-related peptide by radioimmunoassay, we demonstrated that capsaicin-stimulated release of neuropeptides is three to five-fold higher in spinal cord slices from Nf1+/- mice than from wildtype mouse tissue.	Capsaicin	130-139	tachykinin 1	Mus musculus	25-36
16298082-6	2006	Measuring immunoreactive substance P and immunoreactive calcitonin gene-related peptide by radioimmunoassay, we demonstrated that capsaicin-stimulated release of neuropeptides is three to five-fold higher in spinal cord slices from Nf1+/- mice than from wildtype mouse tissue.	Capsaicin	130-139	neurofibromin 1	Mus musculus	232-235
16298082-7	2006	In addition, the potassium and capsaicin-stimulated release of immunoreactive calcitonin gene-related peptide from cultures of sensory neurons isolated from Nf1+/- mice was more than double that from cultures of wildtype neurons.	Capsaicin	31-40	neurofibromin 1	Mus musculus	157-160
16360265-0	2006	Activation of protein kinase B/Akt signaling pathway contributes to mechanical hypersensitivity induced by capsaicin.	Capsaicin	107-116	AKT serine/threonine kinase 1	Rattus norvegicus	31-34
16721838-5	2006	RESULTS: EFS (2-16 Hz, 1 ms duration, 20 sec trains, 75 mA current output) evoked frequency-dependent relaxations which were reduced by the VIP/PACAP receptor antagonist PACAP (6-38) (3 microM), and by the neurotoxin of the capsaicin-sensitive primary afferents capsaicin (10 microM), and abolished by the neuronal voltage-activated Na(+) channel blocker tetrodotoxin (TTX, 1 microM).	Capsaicin	224-233	vasoactive intestinal peptide	Sus scrofa	140-143
16721838-5	2006	RESULTS: EFS (2-16 Hz, 1 ms duration, 20 sec trains, 75 mA current output) evoked frequency-dependent relaxations which were reduced by the VIP/PACAP receptor antagonist PACAP (6-38) (3 microM), and by the neurotoxin of the capsaicin-sensitive primary afferents capsaicin (10 microM), and abolished by the neuronal voltage-activated Na(+) channel blocker tetrodotoxin (TTX, 1 microM).	Capsaicin	224-233	adenylate cyclase activating polypeptide 1	Sus scrofa	144-149
16721838-5	2006	RESULTS: EFS (2-16 Hz, 1 ms duration, 20 sec trains, 75 mA current output) evoked frequency-dependent relaxations which were reduced by the VIP/PACAP receptor antagonist PACAP (6-38) (3 microM), and by the neurotoxin of the capsaicin-sensitive primary afferents capsaicin (10 microM), and abolished by the neuronal voltage-activated Na(+) channel blocker tetrodotoxin (TTX, 1 microM).	Capsaicin	224-233	adenylate cyclase activating polypeptide 1	Sus scrofa	170-175
16721838-5	2006	RESULTS: EFS (2-16 Hz, 1 ms duration, 20 sec trains, 75 mA current output) evoked frequency-dependent relaxations which were reduced by the VIP/PACAP receptor antagonist PACAP (6-38) (3 microM), and by the neurotoxin of the capsaicin-sensitive primary afferents capsaicin (10 microM), and abolished by the neuronal voltage-activated Na(+) channel blocker tetrodotoxin (TTX, 1 microM).	Capsaicin	262-271	vasoactive intestinal peptide	Sus scrofa	140-143
16721838-5	2006	RESULTS: EFS (2-16 Hz, 1 ms duration, 20 sec trains, 75 mA current output) evoked frequency-dependent relaxations which were reduced by the VIP/PACAP receptor antagonist PACAP (6-38) (3 microM), and by the neurotoxin of the capsaicin-sensitive primary afferents capsaicin (10 microM), and abolished by the neuronal voltage-activated Na(+) channel blocker tetrodotoxin (TTX, 1 microM).	Capsaicin	262-271	adenylate cyclase activating polypeptide 1	Sus scrofa	144-149
16721838-5	2006	RESULTS: EFS (2-16 Hz, 1 ms duration, 20 sec trains, 75 mA current output) evoked frequency-dependent relaxations which were reduced by the VIP/PACAP receptor antagonist PACAP (6-38) (3 microM), and by the neurotoxin of the capsaicin-sensitive primary afferents capsaicin (10 microM), and abolished by the neuronal voltage-activated Na(+) channel blocker tetrodotoxin (TTX, 1 microM).	Capsaicin	262-271	adenylate cyclase activating polypeptide 1	Sus scrofa	170-175
16721838-8	2006	CONCLUSIONS: The results suggest that PACAP 38, mainly released from capsaicin-sensitive primary afferents, is involved in the NANC inhibitory neurotransmission of the pig urinary bladder neck, producing relaxation through neuronal and muscle VIP/PACAP receptor activation.	Capsaicin	69-78	adenylate cyclase activating polypeptide 1	Sus scrofa	38-43
16721838-8	2006	CONCLUSIONS: The results suggest that PACAP 38, mainly released from capsaicin-sensitive primary afferents, is involved in the NANC inhibitory neurotransmission of the pig urinary bladder neck, producing relaxation through neuronal and muscle VIP/PACAP receptor activation.	Capsaicin	69-78	vasoactive intestinal peptide	Sus scrofa	243-246
16721838-8	2006	CONCLUSIONS: The results suggest that PACAP 38, mainly released from capsaicin-sensitive primary afferents, is involved in the NANC inhibitory neurotransmission of the pig urinary bladder neck, producing relaxation through neuronal and muscle VIP/PACAP receptor activation.	Capsaicin	69-78	adenylate cyclase activating polypeptide 1	Sus scrofa	247-252
16360265-5	2006	Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.	Capsaicin	188-197	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
16360265-6	2006	Two structurally unrelated phosphoinositide 3-Kinase (PI3K, upstream of PKB/Akt) inhibitors, Wortmannin and LY294002, also prevented the mechanical hypersensitivity induced by intradermal injection of capsaicin.	Capsaicin	201-210	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma	Rattus norvegicus	27-52
16360265-7	2006	Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.	Capsaicin	224-233	AKT serine/threonine kinase 1	Rattus norvegicus	68-71
16360265-7	2006	Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.	Capsaicin	224-233	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
16360265-7	2006	Furthermore, post-treatment with the PI3K inhibitor, Wortmannin, or PKB/Akt inhibitors, such as NL-71-101, SH-6, Akt inhibitor IV, and inhibitor V significantly reduced the established mechanical hypersensitivity induced by capsaicin.	Capsaicin	224-233	AKT serine/threonine kinase 1	Rattus norvegicus	113-116
16360265-1	2006	We investigated the involvement of the protein kinase B/Akt (PKB/Akt) signaling pathway in the mechanical hypersensitivity induced in rats by capsaicin.	Capsaicin	142-151	AKT serine/threonine kinase 1	Rattus norvegicus	39-68
16360265-2	2006	Intradermal injection of capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the dorsal horn, starting by 5 min after capsaicin injection and lasting at least 1h.	Capsaicin	25-34	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
16360265-2	2006	Intradermal injection of capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the dorsal horn, starting by 5 min after capsaicin injection and lasting at least 1h.	Capsaicin	25-34	AKT serine/threonine kinase 1	Rattus norvegicus	64-67
16360265-2	2006	Intradermal injection of capsaicin results in activation of PKB/Akt in the lumbar spinal cord, most prominently in the dorsal horn, starting by 5 min after capsaicin injection and lasting at least 1h.	Capsaicin	156-165	AKT serine/threonine kinase 1	Rattus norvegicus	60-63
16360265-5	2006	Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.	Capsaicin	188-197	AKT serine/threonine kinase 1	Rattus norvegicus	37-40
16360265-5	2006	Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.	Capsaicin	188-197	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
16360265-5	2006	Pre-treatment with several different PKB/Akt inhibitors, including SH-6, Akt inhibitor IV, and Akt inhibitor V, blocked the mechanical hypersensitivity induced by intradermal injection of capsaicin, a measure of spinal cord central sensitization.	Capsaicin	188-197	AKT serine/threonine kinase 1	Rattus norvegicus	73-76
16319926-2	2005	This process, called sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1.	Capsaicin	249-258	kininogen 1	Homo sapiens	115-125
16788306-0	2006	The NK1 receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons.	Capsaicin	46-55	tachykinin receptor 1	Rattus norvegicus	4-16
16788306-0	2006	The NK1 receptor antagonist SR140333 inhibits capsaicin-induced ERK phosphorylation in sensory neurons.	Capsaicin	46-55	Eph receptor B1	Rattus norvegicus	64-67
16788306-4	2006	Capsaicin evoked a threefold increase in phospho-ERK in the sciatic nerve and a two- to threefold increase in the DRG at 3 h and 6 h after the treatment.	Capsaicin	0-9	Eph receptor B1	Rattus norvegicus	49-52
16788306-5	2006	SR140333 markedly attenuated the capsaicin-induced increase in phosphorylated ERK.	Capsaicin	33-42	Eph receptor B1	Rattus norvegicus	78-81
16788306-8	2006	Capsaicin evoked a four- to fivefold increase in phospho-STAT3 in the sciatic nerve and a twofold increase in the DRG at 3 and 6 h after the treatment.	Capsaicin	0-9	signal transducer and activator of transcription 3	Rattus norvegicus	57-62
16788306-9	2006	SR140333 less markedly attenuated the capsaicin-induced increase in phosphorylated STAT3: whereas in the sciatic nerve the difference was significant when the data at 3 h and 6 h were combined (p < 0.05), no such treatment effect of SR140333 was observed in the DRG.	Capsaicin	38-47	signal transducer and activator of transcription 3	Rattus norvegicus	83-88
16788306-10	2006	The expression of TRPV1 mRNA, a specific marker of capsaicin-sensitive small sensory neurons, was investigated by RT-PCR 4 days after the capsaicin treatment.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-23
16788306-10	2006	The expression of TRPV1 mRNA, a specific marker of capsaicin-sensitive small sensory neurons, was investigated by RT-PCR 4 days after the capsaicin treatment.	Capsaicin	138-147	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-23
16788306-12	2006	Based on the present results and previous findings it can be postulated that the capsaicin-induced ERK phosphorylation in sensory neurons is not a direct effect by capsaicin, but that rather substance P release from the stimulated sensory neurons with an NK1-mediated nerve growth factor (NGF) production is involved.	Capsaicin	81-90	Eph receptor B1	Rattus norvegicus	99-102
16288992-5	2005	The various TRPV1 agonists activated pTRPV1 in a dose-dependent manner in the order of potency of resiniferatoxin (RTX) > olvanil > capsaicin > phorbol 12-phenylacetate 13-acetate 20-homovanillate (PPAHV), phorbol 12,13-dinonanoate 20-homovanillate (PDNHV).	Capsaicin	138-147	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
16288992-9	2005	TRPV1 antagonists, iodoRTX, ruthenium red and capsazepine suppressed capsaicin-induced responses.	Capsaicin	69-78	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
18221192-2	2006	TRPV1 is a voltage-dependent cation channel, which can be activated at physiological membrane potentials by stimuli including noxious heat (>42 degrees), capsaicin, hydrogen ions and anandamide.	Capsaicin	157-166	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
16304633-9	2005	Our data suggest heterogeneity of TRPM8 and TRPA1 expression by subpopulations of primary afferent neurons, which may result in the difference of cold-sensitive primary afferent neurons in sensitivity to chemicals such as menthol and capsaicin and nerve growth factor.	Capsaicin	234-243	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	34-39
16304633-9	2005	Our data suggest heterogeneity of TRPM8 and TRPA1 expression by subpopulations of primary afferent neurons, which may result in the difference of cold-sensitive primary afferent neurons in sensitivity to chemicals such as menthol and capsaicin and nerve growth factor.	Capsaicin	234-243	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	44-49
16319926-2	2005	This process, called sensitization or hyperalgesia, is mediated by a variety of proinflammatory factors, including bradykinin, ATP and NGF, which cause sensitization to noxious heat stimuli by enhancing the membrane current carried by the heat- and capsaicin-gated ion channel, TRPV1.	Capsaicin	249-258	ATPase phospholipid transporting 8A2	Homo sapiens	127-138
16095822-2	2005	Moreover, CaMKIIalpha phosphorylates the vanilloid receptor type 1 (TRPV1), thereby regulating vanilloid agonist binding to the receptor.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-73
16298351-1	2005	Vagotomy and capsaicin treatment attenuate dorsal vagal complex (DVC) but not myenteric Fos-like immunoreactivity (Fos-LI) induced by cholecystokinin-8 (CCK-8).	Capsaicin	13-22	cholecystokinin	Rattus norvegicus	153-156
16203144-2	2005	We synthesized various thiazole analogs and evaluated them for their ability to block capsaicin- or acid-induced calcium influx in TRPV1-expressing CHO cells.	Capsaicin	86-95	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	131-136
16095822-4	2005	Inhibition of CaMKIIalpha with KN-93 (5 microM) inhibited capsaicin (CAP)- and n-arachidonoyl-dopamine (NADA)-evoked calcitonin gene-related peptide (CGRP) release effectively decreasing the Emax for both compounds.	Capsaicin	58-67	calcitonin-related polypeptide alpha	Rattus norvegicus	117-148
16095822-4	2005	Inhibition of CaMKIIalpha with KN-93 (5 microM) inhibited capsaicin (CAP)- and n-arachidonoyl-dopamine (NADA)-evoked calcitonin gene-related peptide (CGRP) release effectively decreasing the Emax for both compounds.	Capsaicin	58-67	calcitonin-related polypeptide alpha	Rattus norvegicus	150-154
16095822-4	2005	Inhibition of CaMKIIalpha with KN-93 (5 microM) inhibited capsaicin (CAP)- and n-arachidonoyl-dopamine (NADA)-evoked calcitonin gene-related peptide (CGRP) release effectively decreasing the Emax for both compounds.	Capsaicin	69-72	calcitonin-related polypeptide alpha	Rattus norvegicus	117-148
16051625-7	2005	The TRPV1 receptor antagonist capsazepine prevented the increased cough sensitivity induced by capsaicin.	Capsaicin	95-104	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	4-9
16040630-5	2005	In anesthetized, spontaneously breathing rats, intravenous infusion of bombesin or GRP significantly amplified the pulmonary chemoreflex responses to chemical stimulants such as capsaicin and ATP.	Capsaicin	178-187	gastrin releasing peptide	Rattus norvegicus	83-86
16040630-7	2005	In isolated pulmonary vagal chemosensitive neurons, pretreatment with bombesin or GRP potentiated the capsaicin-induced Ca(2+) transient.	Capsaicin	102-111	gastrin releasing peptide	Rattus norvegicus	82-85
16040630-8	2005	This sensitizing effect was further demonstrated in patch-clamp recording studies; the sensitivities of these neurons to both chemical (capsaicin and ATP) and electrical stimuli were significantly enhanced by the presence of either bombesin or GRP.	Capsaicin	136-145	gastrin releasing peptide	Rattus norvegicus	244-247
16093333-5	2005	Using patch-clamp electrophysiological techniques, we examined the excitability of capsaicin-sensitive sensory neurons isolated from the dorsal root ganglia of adult mice with a heterozygous mutation of the Nf1 gene (Nf1+/-), analogous to the human mutation, in comparison to wildtype sensory neurons.	Capsaicin	83-92	neurofibromin 1	Mus musculus	207-210
16093333-5	2005	Using patch-clamp electrophysiological techniques, we examined the excitability of capsaicin-sensitive sensory neurons isolated from the dorsal root ganglia of adult mice with a heterozygous mutation of the Nf1 gene (Nf1+/-), analogous to the human mutation, in comparison to wildtype sensory neurons.	Capsaicin	83-92	neurofibromin 1	Mus musculus	217-220
16477145-7	2005	In the patch-clamp experiments, we observed capsaicin-induced inward currents that were inhibited by capsazepine, a TRPV1 channel antagonist.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	116-121
16477149-0	2005	Activation of the caspase cascade underlies the rat trigeminal primary neuronal apoptosis induced by neonatal capsaicin administration.	Capsaicin	110-119	caspase 9	Rattus norvegicus	18-25
16477149-2	2005	Here we examined the trigeminal ganglion neurons immunohistochemically for the possible induction of activated forms of caspases-9 and -3 following a subcutaneous injection of capsaicin in newborn rats.	Capsaicin	176-185	caspase 9	Rattus norvegicus	120-137
16477149-5	2005	After the capsaicin injection, TUNEL-positive neurons began to increase by 12 h, reached a peak at 24 h (11.4%), and returned to the control level by 120 h. Vehicle control levels of caspase- 9-immunoreactive (ir) and caspase-3-ir neurons were low (< 0.5%).	Capsaicin	10-19	caspase 9	Rattus norvegicus	183-193
16477149-5	2005	After the capsaicin injection, TUNEL-positive neurons began to increase by 12 h, reached a peak at 24 h (11.4%), and returned to the control level by 120 h. Vehicle control levels of caspase- 9-immunoreactive (ir) and caspase-3-ir neurons were low (< 0.5%).	Capsaicin	10-19	caspase 3	Rattus norvegicus	218-227
16477149-6	2005	Neonatal capsaicin administration induced caspase-9-immunoreactivity (ir) and -3-ir.	Capsaicin	9-18	caspase 9	Rattus norvegicus	42-51
16477149-11	2005	These results suggest that neonatal capsaicin triggers the caspase cascade and, thereby, induces trigeminal primary neuronal apoptosis.	Capsaicin	36-45	caspase 9	Rattus norvegicus	59-66
16477150-0	2005	Postnatal development of substance P-immunoreaction in the trigeminal caudalis of neonatally capsaicin-treated mice.	Capsaicin	93-102	tachykinin 1	Mus musculus	25-36
16477150-2	2005	Although an administration of capsaicin in neonates induces a selective destruction of substance P (SP)-immunoreactive nerve fibers, little information is available regarding its detailed effects on the Vc, particularly during postnatal development.	Capsaicin	30-39	tachykinin 1	Mus musculus	87-98
16477150-2	2005	Although an administration of capsaicin in neonates induces a selective destruction of substance P (SP)-immunoreactive nerve fibers, little information is available regarding its detailed effects on the Vc, particularly during postnatal development.	Capsaicin	30-39	tachykinin 1	Mus musculus	100-102
16477150-3	2005	The present study examined postnatal changes in the distribution of SP in the Vc and trigeminal ganglion (TG) by immunohistochemical techniques in naive (NV) and neonatally capsaicin-treated (CP) mice, combined with a quantitative analysis.	Capsaicin	173-182	tachykinin 1	Mus musculus	68-70
16326368-7	2005	Capsaicin-evoked Fos protein expression was increased in the superficial and neck regions of the dorsal horn of adult P0-CFA-treated rats relative to P0-vehicle-treated rats.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-20
16135784-1	2005	Vanilloid receptor 1 (TRPV1) is activated by chemical ligands (e.g., capsaicin and protons) and heat.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-20
16135784-1	2005	Vanilloid receptor 1 (TRPV1) is activated by chemical ligands (e.g., capsaicin and protons) and heat.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
15998524-5	2005	In vitro, BCTC inhibited capsaicin (300 nM)-induced releases of calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) and substance P-like immunoreactivity (SP-LI) from the rat spinal cord slice preparations with IC(50)s of 37.0 and 36.0 nM, respectively, confirming that BCTC potently inhibits TRPV1 function in the rat spinal cord.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	305-310
16305749-8	2005	Remarkably few (9%) ASIC3+ cells express P2X3 receptors (an ATP-gated ion channel), whereas 31% express TRPV1 (the noxious heat and capsaicin-activated ion channel also known as VR1).	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	178-181
15882882-11	2005	These results indicate that capsaicin activates a TRPV1-independent non-SOCE pathway in neutrophils.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	50-55
16216696-0	2005	TRPV1 desensitisation and endogenous vanilloid involvement in the enhanced analgesia induced by capsaicin in inflamed tissues.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
16216696-3	2005	Since this reduction of capsaicin-induced licking behavior may be interpreted as a consequence of the transient receptor potential vanilloid 1 receptor (TRPV1) unresponsiveness, we conclude that the administration of 10 microg of capsaicin into inflamed tissues can render the TRPV1 desensitised.	Capsaicin	230-239	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	102-151
16216696-3	2005	Since this reduction of capsaicin-induced licking behavior may be interpreted as a consequence of the transient receptor potential vanilloid 1 receptor (TRPV1) unresponsiveness, we conclude that the administration of 10 microg of capsaicin into inflamed tissues can render the TRPV1 desensitised.	Capsaicin	230-239	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	277-282
16216696-7	2005	From these results, it may be proposed that the maintenance by endovanilloids of the TRPV1 desensitisation induced by capsaicin could contribute to prolonging the analgesic effect induced by this agonist in inflamed tissues.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	85-90
16269136-1	2005	It is discussed whether capsaicin, an agonist of the pain mediating TRPV1 receptor, decreases or increases voltage-activated calcium channel (VACC) currents (I(Ca(V))).	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-73
16269136-10	2005	These effects of capsaicin on different VACCs in small DRG neurones, which most likely express the TRPV1 receptor, may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	218-223
16269136-10	2005	These effects of capsaicin on different VACCs in small DRG neurones, which most likely express the TRPV1 receptor, may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
16269136-10	2005	These effects of capsaicin on different VACCs in small DRG neurones, which most likely express the TRPV1 receptor, may represent another mechanism of action of the pungent substance capsaicin in addition to opening of TRPV1.	Capsaicin	182-191	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
16425415-8	2005	Co-treatment of exogenous calcitonine gene-related peptide (CGRP) with GSE restored the protection and accompanying hyperemic effects of GSE in rats with capsaicin denervation.	Capsaicin	154-163	calcitonin-related polypeptide alpha	Rattus norvegicus	26-58
16425415-8	2005	Co-treatment of exogenous calcitonine gene-related peptide (CGRP) with GSE restored the protection and accompanying hyperemic effects of GSE in rats with capsaicin denervation.	Capsaicin	154-163	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
16232161-10	2005	However, the increases in the plasma CGRP concentrations by capsaicin remained essentially unmodified after GR79236 treatment.	Capsaicin	60-69	Calcitonin gene-related peptide	Sus scrofa	37-41
16100528-2	2005	Previously, selective mutagenesis experiments identified an intracellular residue (S512Y) critical to discriminating between pH and vanilloid (capsaicin) gating of the rat TRPV1 receptor.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	172-177
16100528-2	2005	Previously, selective mutagenesis experiments identified an intracellular residue (S512Y) critical to discriminating between pH and vanilloid (capsaicin) gating of the rat TRPV1 receptor.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	172-177
16100528-3	2005	2 In this study, switching the equivalent residue in the human TRPV1 (which has some significant differences with the rat TRPV1) also rendered this channel relatively insensitive to activation by capsaicin and proved critical in determining the receptor"s sensitivity to the putative endovanilloid N-arachidonoyl-dopamine (NADA), suggesting a similar mode of activation for these two agonists.	Capsaicin	196-205	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
16100528-3	2005	2 In this study, switching the equivalent residue in the human TRPV1 (which has some significant differences with the rat TRPV1) also rendered this channel relatively insensitive to activation by capsaicin and proved critical in determining the receptor"s sensitivity to the putative endovanilloid N-arachidonoyl-dopamine (NADA), suggesting a similar mode of activation for these two agonists.	Capsaicin	196-205	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	122-127
16272787-4	2005	In preparations treated with capsaicin (a CGRP depletor), pressor responses to both PNS and NE injection were markedly attenuated by AM.	Capsaicin	29-38	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
16207293-20	2005	Both the protection and the hyperemia were restored by addition of exogenous CGRP to capsaicin-denervated animals.	Capsaicin	85-94	calcitonin-related polypeptide alpha	Rattus norvegicus	77-81
15935516-7	2005	Perfusion of 10nM calcitonin gene-related peptide (CGRP) or 0.1 microM capsaicin (inducer of CGRP release) inhibited significantly the spontaneous AM release.	Capsaicin	71-80	calcitonin-related polypeptide alpha	Rattus norvegicus	93-97
16202530-5	2005	Here we studied the effects of histamine H1 and H2 receptors on orexin A-produced antinociception using histamine receptor knockout mice in four assays of nociception; the hot-plate, the tail-flick, the tail-pressure and the capsaicin tests.	Capsaicin	225-234	hypocretin	Mus musculus	64-72
15935516-7	2005	Perfusion of 10nM calcitonin gene-related peptide (CGRP) or 0.1 microM capsaicin (inducer of CGRP release) inhibited significantly the spontaneous AM release.	Capsaicin	71-80	adrenomedullin	Rattus norvegicus	147-149
16137500-2	2005	The sensory neurotoxin capsaicin prevented the expected increases of CGRP and substance P in the submandibular glands and of VIP in the parotid glands.	Capsaicin	23-32	calcitonin-related polypeptide alpha	Rattus norvegicus	69-73
16141720-11	2005	The present study demonstrates that a capsaicin impairment of small diameter primary sensory neurons followed by an NGF treatment evokes a characteristic pattern of ERK and STAT3 activation indicative of neuronal degeneration and regeneration.	Capsaicin	38-47	signal transducer and activator of transcription 3	Rattus norvegicus	173-178
16251436-6	2005	Capsaicin-evoked responses mediated by the TRPV1 receptor were unaltered in transgenic mice.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
16141720-0	2005	ERK and STAT3 phosphorylation in sensory neurons during capsaicin-induced impairment and nerve growth factor treatment.	Capsaicin	56-65	Eph receptor B1	Rattus norvegicus	0-3
16141720-0	2005	ERK and STAT3 phosphorylation in sensory neurons during capsaicin-induced impairment and nerve growth factor treatment.	Capsaicin	56-65	signal transducer and activator of transcription 3	Rattus norvegicus	8-13
16141720-4	2005	Phosphorylation of ERK clearly peaked in the sciatic nerve and in the lumbar DRGs at 6 and 10 h after the capsaicin treatment.	Capsaicin	106-115	Eph receptor B1	Rattus norvegicus	19-22
16141720-6	2005	An additional intraplantar nerve growth factor (NGF) injection at time points 20, 44 and 92 h after the capsaicin treatment, and collection of tissues 4 h later, markedly increased the level of phospho-ERK in the sciatic nerve as well as in the DRG, as compared to the samples taken from rats at the same time points with a capsaicin treatment only.	Capsaicin	104-113	nerve growth factor	Rattus norvegicus	27-46
16141720-6	2005	An additional intraplantar nerve growth factor (NGF) injection at time points 20, 44 and 92 h after the capsaicin treatment, and collection of tissues 4 h later, markedly increased the level of phospho-ERK in the sciatic nerve as well as in the DRG, as compared to the samples taken from rats at the same time points with a capsaicin treatment only.	Capsaicin	104-113	nerve growth factor	Rattus norvegicus	48-51
16141720-6	2005	An additional intraplantar nerve growth factor (NGF) injection at time points 20, 44 and 92 h after the capsaicin treatment, and collection of tissues 4 h later, markedly increased the level of phospho-ERK in the sciatic nerve as well as in the DRG, as compared to the samples taken from rats at the same time points with a capsaicin treatment only.	Capsaicin	324-333	nerve growth factor	Rattus norvegicus	27-46
16141720-6	2005	An additional intraplantar nerve growth factor (NGF) injection at time points 20, 44 and 92 h after the capsaicin treatment, and collection of tissues 4 h later, markedly increased the level of phospho-ERK in the sciatic nerve as well as in the DRG, as compared to the samples taken from rats at the same time points with a capsaicin treatment only.	Capsaicin	324-333	nerve growth factor	Rattus norvegicus	48-51
16141720-7	2005	Posphorylated STAT3, which was almost non-detectable in the control sciatic nerve, clearly peaked at 6 h after the capsaicin treatment and decreased again during the following days to almost undetectable levels.	Capsaicin	115-124	signal transducer and activator of transcription 3	Rattus norvegicus	14-19
16141720-9	2005	A basal level of phosphorylated STAT3 was present in DRGs of control animals, it remained at a high level up to 6 h after the capsaicin treatment, then markedly decreased and recovered on day 8 and day 16.	Capsaicin	126-135	signal transducer and activator of transcription 3	Rattus norvegicus	32-37
16141720-10	2005	NGF increased STAT3 phosphorylation in DRG on day 1 and day 2 above the level observed in samples taken from rats at the same time points with a capsaicin treatment only.	Capsaicin	145-154	nerve growth factor	Rattus norvegicus	0-3
16141720-10	2005	NGF increased STAT3 phosphorylation in DRG on day 1 and day 2 above the level observed in samples taken from rats at the same time points with a capsaicin treatment only.	Capsaicin	145-154	signal transducer and activator of transcription 3	Rattus norvegicus	14-19
16141720-11	2005	The present study demonstrates that a capsaicin impairment of small diameter primary sensory neurons followed by an NGF treatment evokes a characteristic pattern of ERK and STAT3 activation indicative of neuronal degeneration and regeneration.	Capsaicin	38-47	nerve growth factor	Rattus norvegicus	116-119
16141720-11	2005	The present study demonstrates that a capsaicin impairment of small diameter primary sensory neurons followed by an NGF treatment evokes a characteristic pattern of ERK and STAT3 activation indicative of neuronal degeneration and regeneration.	Capsaicin	38-47	Eph receptor B1	Rattus norvegicus	165-168
16419151-4	2005	By using Western blotting methods, capsaicin reduced the expression of Bcl-2, the antiapoptotic protein, in AGS cells in a concentration-dependent manner.	Capsaicin	35-44	BCL2 apoptosis regulator	Homo sapiens	71-76
16419151-9	2005	CONCLUSION: These results suggest that capsaicin-induced cell death might be via a Bcl-2 sensitive apoptotic pathway.	Capsaicin	39-48	BCL2 apoptosis regulator	Homo sapiens	83-88
16212954-3	2005	Mutant mice lacking histidine decarboxylase showed significantly fewer nociceptive responses to the hot-plate, tail-flick, paw-withdrawal, tail-pressure, formalin and capsaicin tests.	Capsaicin	167-176	histidine decarboxylase	Mus musculus	20-43
16081483-3	2005	The NO release elicited by either anandamide or capsaicin was reduced by the TRPV1 receptor antagonists 5"-iodoresiniferatoxin, SB 366791 and capsazepine as well as by the cannabinoid CB(1) receptor antagonists SR 141716A or AM251.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	77-82
16168409-0	2005	Capsaicin-induced effects on c-fos expression and NADPH-diaphorase activity in the feline spinal cord.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	29-34
16168409-2	2005	After the unilateral intramuscular injection of capsaicin, the mean number of Fos-immunoreactive neurons detected with an avidin-biotin-peroxidase technique was significantly increased in the superficial laminae (I), neck of the dorsal horn (V), and area around the central canal (VII) within both the cervical and lumbar spinal cord.	Capsaicin	48-57	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	78-81
15920018-5	2005	Subdiaphragmatic vagotomy and perivagal application of capsaicin, but not supranodose vagotomy, completely abolished the secretin-elicited vagal nodose neuronal response.	Capsaicin	55-64	secretin	Rattus norvegicus	121-129
16137500-2	2005	The sensory neurotoxin capsaicin prevented the expected increases of CGRP and substance P in the submandibular glands and of VIP in the parotid glands.	Capsaicin	23-32	vasoactive intestinal peptide	Rattus norvegicus	125-128
16137500-6	2005	In the parasympathetically denervated glands, the capsaicin-sensitive contribution to the CGRP-response to sympathetic denervation was roughly estimated to be more than 25% but less than 40%, while the corresponding contribution to the substance P-response was roughly estimated to be more than 6% but less than 58%.	Capsaicin	50-59	calcitonin-related polypeptide alpha	Rattus norvegicus	90-94
16056236-6	2005	The TRPV1 antagonist capsazepine (1 mM) reduced the response to capsaicin (100 microM), from 1.78+/-0.15 to 0.63+/-0.10 (n = 4).	Capsaicin	64-73	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
16056236-7	2005	The NK1 receptor antagonists GR205171 (100 microM) and SDZ NKT 376 (1 mM) also reduced the response to capsaicin (from 1.75+/-0.14 to 0.46+/-0.08; n = 6, and from 1.85+/-0.13 to 0.48+/-0.05; n = 5, respectively), indicating that capsaicin acts via TRPV1 in series with NK(1).	Capsaicin	103-112	tachykinin receptor 1	Rattus norvegicus	4-16
16056236-7	2005	The NK1 receptor antagonists GR205171 (100 microM) and SDZ NKT 376 (1 mM) also reduced the response to capsaicin (from 1.75+/-0.14 to 0.46+/-0.08; n = 6, and from 1.85+/-0.13 to 0.48+/-0.05; n = 5, respectively), indicating that capsaicin acts via TRPV1 in series with NK(1).	Capsaicin	103-112	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	248-253
16056236-7	2005	The NK1 receptor antagonists GR205171 (100 microM) and SDZ NKT 376 (1 mM) also reduced the response to capsaicin (from 1.75+/-0.14 to 0.46+/-0.08; n = 6, and from 1.85+/-0.13 to 0.48+/-0.05; n = 5, respectively), indicating that capsaicin acts via TRPV1 in series with NK(1).	Capsaicin	229-238	tachykinin receptor 1	Rattus norvegicus	4-16
16191202-1	2005	TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C. These activators can enhance the potency of one another, shifting the activation curve for TRPV1 to the left.	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	7-27
16087784-1	2005	To test the hypothesis that activation of the vanilloid receptor 1 (VR1) expressed in sensory nerves innervating the renal pelvis leads to diuresis and natriuresis, a selective VR1 receptor agonist, capsaicin (2.4 nmol), or vehicle was perfused intravenously or into the left renal pelvis of anesthetized rats at a rate without changing renal perfusion pressure.	Capsaicin	199-208	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	46-66
16087784-1	2005	To test the hypothesis that activation of the vanilloid receptor 1 (VR1) expressed in sensory nerves innervating the renal pelvis leads to diuresis and natriuresis, a selective VR1 receptor agonist, capsaicin (2.4 nmol), or vehicle was perfused intravenously or into the left renal pelvis of anesthetized rats at a rate without changing renal perfusion pressure.	Capsaicin	199-208	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-71
16087784-3	2005	Capsaicin perfusion into the left renal pelvis but not intravenously caused significant increases in urine flow rate and urinary sodium excretion bilaterally in a dose-dependent manner, which were abolished by capsazepine, a selective VR1 receptor antagonist, given ipsilaterally to the renal pelvis or by ipsilateral renal denervation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	235-238
15985616-10	2005	These results suggested that both capsaicin and acid increase gastric HCO3(-) secretion via a common pathway, involving PG and NO as well as capsaicin-sensitive afferent neurons, yet their responses differ concerning TRPV1 or prostanoid receptor dependence.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	217-222
16150543-1	2005	Capsaicin-sensitive, TRPV1 (transient receptor potential vanilloid 1) receptor-expressing primary sensory neurons exert local and systemic efferent effects besides the classical afferent function.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	21-26
16150543-1	2005	Capsaicin-sensitive, TRPV1 (transient receptor potential vanilloid 1) receptor-expressing primary sensory neurons exert local and systemic efferent effects besides the classical afferent function.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-68
16191202-0	2005	Acidification of rat TRPV1 alters the kinetics of capsaicin responses.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	21-26
16191202-1	2005	TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C. These activators can enhance the potency of one another, shifting the activation curve for TRPV1 to the left.	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
16144988-5	2005	Likewise, administration of capsaicin, a selective VR1 receptor agonist, dose-dependently decreased MAP in both HS- and NS-treated rats.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-54
16218380-3	2005	Recent advance, especially the identification of TRPV1 receptor (for which capsaicin, protons and heat are ligands), P2X and P2Y receptor (for which ATP is a ligand) and acid sensing ion channel made a remarkable progress in understanding the mechanism of nociceptive neurons.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
16140298-5	2005	In contrast, capsaicin evoked a sustained increase in [Ca(2+)] and large inwards currents in sensory neurons and TRPV1-expressing HEK293 cells.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-118
16191202-1	2005	TRPV1 (vanilloid receptor 1) receptors are activated by a variety of ligands such as capsaicin, as well as by acidic conditions and temperatures above 42 degrees C. These activators can enhance the potency of one another, shifting the activation curve for TRPV1 to the left.	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	256-261
16191202-2	2005	In this study, for example, we observed an approximately 10-fold shift in the capsaicin EC50 (640 nM to 45 nM) for rat TRPV1 receptors expressed in HEK-293 cells when the pH was lowered from 7.4 to 5.5.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	119-124
16191202-7	2005	When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	5-10
16191202-7	2005	When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	139-144
16191202-7	2005	When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	5-10
16191202-7	2005	When TRPV1 was maximally activated by capsaicin and acidic pH, the apparent affinity of the novel and selective capsaicin-site competitive TRPV1 antagonist, A-425619, was reduced approximately 35 fold.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	139-144
16192383-3	2005	Capsaicin and menthol, two other topically applied agents widely used for similar purposes, are known to excite and desensitize sensory nerves by acting on two members of transient receptor potential (TRP) channel superfamily: heat-sensitive TRP vanilloid subtype 1 (TRPV1) and cold-sensitive TRP channel M8, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	242-265
16192383-3	2005	Capsaicin and menthol, two other topically applied agents widely used for similar purposes, are known to excite and desensitize sensory nerves by acting on two members of transient receptor potential (TRP) channel superfamily: heat-sensitive TRP vanilloid subtype 1 (TRPV1) and cold-sensitive TRP channel M8, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	267-272
16125151-2	2005	Intraplantar GAL at low doses enhances capsaicin (CAP)-induced pain behaviors in rat, suggesting an excitatory role for GAL under acute inflammatory conditions.	Capsaicin	39-48	galanin and GMAP prepropeptide	Rattus norvegicus	13-16
16192383-7	2005	Camphor activation of rat TRPV1 was mediated by distinct channel regions from capsaicin, as indicated by camphor activation in the presence of the competitive inhibitor capsazepine and in a capsaicin-insensitive point mutant.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
16125151-2	2005	Intraplantar GAL at low doses enhances capsaicin (CAP)-induced pain behaviors in rat, suggesting an excitatory role for GAL under acute inflammatory conditions.	Capsaicin	50-53	galanin and GMAP prepropeptide	Rattus norvegicus	13-16
16125151-4	2005	Thus, the present study investigated the role of protein kinase C (PKC) in the GAL enhancement of CAP-induced inflammatory pain.	Capsaicin	98-101	galanin and GMAP prepropeptide	Rattus norvegicus	79-82
16192383-7	2005	Camphor activation of rat TRPV1 was mediated by distinct channel regions from capsaicin, as indicated by camphor activation in the presence of the competitive inhibitor capsazepine and in a capsaicin-insensitive point mutant.	Capsaicin	190-199	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
16192383-9	2005	TRPV1 desensitization is believed to contribute to the analgesic actions of capsaicin.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
16162281-5	2005	Relative to vehicle, HCl (0.5 M) and capsaicin (3.2 mM) increased c-fos transcription in the nucleus tractus solitarii by factors of 7.0 and 2.1, respectively.	Capsaicin	37-46	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-71
16162281-6	2005	Capsaicin also caused a 5.2-fold rise of c-fos mRNA expression in lamina I of the caudal thoracic spinal cord, although the number of c-fos mRNA-positive cells in this lamina was very small.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-46
16162281-6	2005	Capsaicin also caused a 5.2-fold rise of c-fos mRNA expression in lamina I of the caudal thoracic spinal cord, although the number of c-fos mRNA-positive cells in this lamina was very small.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	134-139
15950380-2	2005	The present paper characterizes the effects of SB366791, a novel TRPV1 antagonist, on capsaicin-evoked responses both in vitro and in vivo using rat models.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	65-70
16159392-6	2005	This study was designed to use Western blot analysis to investigate the role of mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase (MEK 1/2), PKA and PKC in regulating the phosphorylation of CREB in the spinal cord of rats following intraplantar capsaicin injection.	Capsaicin	278-287	cAMP responsive element binding protein 1	Rattus norvegicus	223-227
16159392-0	2005	Protein kinases mediate increment of the phosphorylation of cyclic AMP-responsive element binding protein in spinal cord of rats following capsaicin injection.	Capsaicin	139-148	cAMP responsive element binding protein 1	Rattus norvegicus	60-105
16159392-7	2005	RESULTS: We found that capsaicin injection significantly increased the phosphorylation level of CREB in the ipsilateral side of the spinal cord.	Capsaicin	23-32	cAMP responsive element binding protein 1	Rattus norvegicus	96-100
16459489-3	2005	The study aimed to estimate the influence of ambroxol (ABX) and capsaicin (CAPSA) on PD and dPD in isolated rabbit bladder.	Capsaicin	64-73	dachs	Drosophila melanogaster	85-87
16159392-6	2005	This study was designed to use Western blot analysis to investigate the role of mitogen-activated protein (MAP)/extracellular signal-regulated kinase (ERK) kinase (MEK 1/2), PKA and PKC in regulating the phosphorylation of CREB in the spinal cord of rats following intraplantar capsaicin injection.	Capsaicin	278-287	mitogen activated protein kinase kinase 1	Rattus norvegicus	164-171
16459489-3	2005	The study aimed to estimate the influence of ambroxol (ABX) and capsaicin (CAPSA) on PD and dPD in isolated rabbit bladder.	Capsaicin	75-80	dachs	Drosophila melanogaster	85-87
15905220-4	2005	To test this hypothesis, we quantified expression of Fos-like immunoreactivity (Fos) in the dorsal vagal complex (DVC) of capsaicin-treated (Cap) and control rats (Veh), following gastric balloon distension alone and in combination with CCK injection.	Capsaicin	122-131	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-78
15905220-4	2005	To test this hypothesis, we quantified expression of Fos-like immunoreactivity (Fos) in the dorsal vagal complex (DVC) of capsaicin-treated (Cap) and control rats (Veh), following gastric balloon distension alone and in combination with CCK injection.	Capsaicin	122-131	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-56
15905220-0	2005	CCK enhances response to gastric distension by acting on capsaicin-insensitive vagal afferents.	Capsaicin	57-66	cholecystokinin	Rattus norvegicus	0-3
15905220-9	2005	We conclude that CCK directly activates capsaicin-sensitive C-type vagal afferents.	Capsaicin	40-49	cholecystokinin	Rattus norvegicus	17-20
15905220-1	2005	Capsaicin treatment destroys vagal afferent C fibers and markedly attenuates reduction of food intake and induction of hindbrain Fos expression by CCK.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	129-132
15905220-10	2005	However, in capsaicin-resistant A-type afferents, CCK"s principal action may be facilitation of responses to gastric distension.	Capsaicin	12-21	cholecystokinin	Rattus norvegicus	50-53
15905220-1	2005	Capsaicin treatment destroys vagal afferent C fibers and markedly attenuates reduction of food intake and induction of hindbrain Fos expression by CCK.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	147-150
16247188-5	2005	This protective action of gut hormones has been attributed to the release of PG or activation of sensory nerves because it could be abolished by the pretreatment with indomethacin or large neurotoxic dose of capsaicin and restored by the addition of exogenous PGE(2) or CGRP, respectively.	Capsaicin	208-217	calcitonin related polypeptide alpha	Homo sapiens	270-274
15905220-3	2005	Because CCK enhances behavioral and electrophysiological responses to gastric distension in rats and people, we hypothesized that CCK might enhance the vagal afferent response to gastric distension via an action on capsaicin-insensitive vagal afferents.	Capsaicin	215-224	cholecystokinin	Homo sapiens	130-133
15994849-12	2005	), a selective VR1 antagonist, inhibited the capsaicin-evoked response, but not that of propofol.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	15-18
15997233-8	2005	The TRPV1 agonists capsaicin, olvanil and arvanil all induced concentration-dependent increases in skin blood flow and burning pain when administered dermally.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	22-31	interleukin 6	Homo sapiens	40-44
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Homo sapiens	80-83
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	interleukin 6	Homo sapiens	152-156
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	interleukin 6	Homo sapiens	152-156
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Homo sapiens	233-236
15947039-1	2005	Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin- and heat-gated ion channel required for normal in vivo responses to these painful stimuli.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
15947039-1	2005	Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin- and heat-gated ion channel required for normal in vivo responses to these painful stimuli.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
15947039-5	2005	In response to I-RTX in vitro, HEK293 cells expressing rat TRPV1 exhibited increases in intracellular Ca(2+) (biphasic, EC(50) = 56.7 nM and 9.9 microM) that depended on Ca(2+) influx and outwardly rectifying, capsazepine-sensitive currents that were smaller than those evoked by 1 microM capsaicin.	Capsaicin	289-298	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Homo sapiens	80-83
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	interleukin 6	Homo sapiens	152-156
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	interleukin 6	Homo sapiens	152-156
16123700-2	2005	As revealed by ELISA, capsaicin induced IL-6 expression in PF-10 cells, and the VR1 antagonist capsazepine dose-dependently inhibited capsaicin-induced IL-6 production, indicating that capsaicin-induced IL-6 expression is related to VR1 activation.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Homo sapiens	233-236
16123700-4	2005	The phosphorylation of p38 MAPK and c-Jun NH2-terminal kinase (JNK) were detected after capsaicin stimulation.	Capsaicin	88-97	mitogen-activated protein kinase 14	Homo sapiens	23-26
16123700-4	2005	The phosphorylation of p38 MAPK and c-Jun NH2-terminal kinase (JNK) were detected after capsaicin stimulation.	Capsaicin	88-97	mitogen-activated protein kinase 8	Homo sapiens	36-61
16123700-4	2005	The phosphorylation of p38 MAPK and c-Jun NH2-terminal kinase (JNK) were detected after capsaicin stimulation.	Capsaicin	88-97	mitogen-activated protein kinase 8	Homo sapiens	63-66
16123700-5	2005	p38 MAPK is involved in capsaicin-induced IL-6 production, as shown by the use of specific inhibitors of this kinase.	Capsaicin	24-33	mitogen-activated protein kinase 14	Homo sapiens	0-3
16123700-5	2005	p38 MAPK is involved in capsaicin-induced IL-6 production, as shown by the use of specific inhibitors of this kinase.	Capsaicin	24-33	interleukin 6	Homo sapiens	42-46
16123700-6	2005	The result of EMSA showed that capsaicin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappa B (NF-kappaB) activation in PF-10 cell cultures.	Capsaicin	31-40	tumor necrosis factor	Homo sapiens	51-78
16123700-6	2005	The result of EMSA showed that capsaicin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappa B (NF-kappaB) activation in PF-10 cell cultures.	Capsaicin	31-40	tumor necrosis factor	Homo sapiens	80-89
16123700-6	2005	The result of EMSA showed that capsaicin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappa B (NF-kappaB) activation in PF-10 cell cultures.	Capsaicin	31-40	nuclear factor kappa B subunit 1	Homo sapiens	99-121
16123700-6	2005	The result of EMSA showed that capsaicin inhibited tumor necrosis factor-alpha (TNF-alpha)-induced nuclear factor-kappa B (NF-kappaB) activation in PF-10 cell cultures.	Capsaicin	31-40	nuclear factor kappa B subunit 1	Homo sapiens	123-132
15967874-1	2005	At submicromolar concentrations, capsaicin specifically activates the TRPV1 receptor involved in nociception.	Capsaicin	33-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
15936040-1	2005	After 7 years from its cloning, the transient receptor potential vanilloid type-1 (TRPV1) channel remains the sole membrane receptor mediating the pharmacological effects of the hot chilli pepper pungent component, capsaicin, and of the Euphorbia toxin, resiniferatoxin.	Capsaicin	215-224	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-81
15908510-10	2005	The naloxone-induced internalization was blocked by NK1r antagonist L-703,606 [cis-2-(diphenylmethyl)-N-[(2-iodophenyl)methyl]-1 azabicyclo[2.2.2]octan-3-amine] or pretreatment with capsaicin, confirming that the internalization is due to the endogenous SP release from the primary afferents.	Capsaicin	182-191	tachykinin receptor 1	Rattus norvegicus	52-56
16112410-1	2005	Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	225-256
16112410-1	2005	Capsaicin-sensitive sensory nerves participate in the regulation of cardiovascular functions both in the normal state and the pathophysiology of hypertension through the actions of potent vasodilator neuropeptides, including calcitonin gene-related peptide (CGRP).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	258-262
16112410-2	2005	CGRP, a very potent vasodilator, is the predominant neurotransmitter in capsaicin-sensitive sensory nerves, and plays an important role in the initiation, progression and maintenance of hypertension via: (1) the alterations in its synthesis and release and/or in vascular sensitivity response to it; (2) interactions with pro-hypertensive systems, including renin-angiotensin-aldosterone system, sympathetic nervous system and endothelin system; and (3) anti-hypertrophy and anti-proliferation of vascular smooth muscle cells.	Capsaicin	72-81	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
16043235-3	2005	A recent study shows that piperine, the irritant principle in black pepper, is more efficient than capsaicin in the desensitization of human TRPV1, which suggests that this pharmacological aspect of vanilloids can be dissociated from its potency.	Capsaicin	99-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	141-146
15919130-1	2005	The present study investigates the role of serine/threonine protein phosphatase 2A (PP2A) in the modulation of the phosphorylation of the NR1 and NR2B subunits of NMDA receptors in the spinal cord of rats following intradermal injection of capsaicin.	Capsaicin	240-249	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	138-141
15919130-6	2005	We found that the upregulated phosphorylation of both NR1 and NR2B subunits induced by capsaicin injection was significantly potentiated by the PP2A inhibitor without affecting the NR1 and NR2B protein itself.	Capsaicin	87-96	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	54-57
15919130-6	2005	We found that the upregulated phosphorylation of both NR1 and NR2B subunits induced by capsaicin injection was significantly potentiated by the PP2A inhibitor without affecting the NR1 and NR2B protein itself.	Capsaicin	87-96	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	62-66
15919130-6	2005	We found that the upregulated phosphorylation of both NR1 and NR2B subunits induced by capsaicin injection was significantly potentiated by the PP2A inhibitor without affecting the NR1 and NR2B protein itself.	Capsaicin	87-96	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	181-184
15919130-6	2005	We found that the upregulated phosphorylation of both NR1 and NR2B subunits induced by capsaicin injection was significantly potentiated by the PP2A inhibitor without affecting the NR1 and NR2B protein itself.	Capsaicin	87-96	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	189-193
15936040-1	2005	After 7 years from its cloning, the transient receptor potential vanilloid type-1 (TRPV1) channel remains the sole membrane receptor mediating the pharmacological effects of the hot chilli pepper pungent component, capsaicin, and of the Euphorbia toxin, resiniferatoxin.	Capsaicin	215-224	transient receptor potential cation channel subfamily V member 1	Homo sapiens	83-88
15977164-8	2005	Furthermore, microinjections of BDNF into the spinal cord or release of endogenous BDNF by intraplantar injection of capsaicin activated ERK phosphorylation in TrkB-containing STT neurons.	Capsaicin	117-126	brain-derived neurotrophic factor	Rattus norvegicus	83-87
15977164-8	2005	Furthermore, microinjections of BDNF into the spinal cord or release of endogenous BDNF by intraplantar injection of capsaicin activated ERK phosphorylation in TrkB-containing STT neurons.	Capsaicin	117-126	Eph receptor B1	Rattus norvegicus	137-140
15977164-8	2005	Furthermore, microinjections of BDNF into the spinal cord or release of endogenous BDNF by intraplantar injection of capsaicin activated ERK phosphorylation in TrkB-containing STT neurons.	Capsaicin	117-126	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	160-164
16133936-3	2005	Activation of ionotropic P2X receptors in sensory neurons has been implicated in induction of pain, whereas metabotropic P2Y receptors in potentiation of pain induced by chemical or physical stimuli via capsaicin sensitive TRPV1 channel.	Capsaicin	203-212	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	223-228
16081834-7	2005	Ablation of sensory neurons (by capsaicin) markedly decreased the PAR2-mediated airway constriction, and virtually abolished PAR2-mediated pulmonary inflammation and edema, as did blockade of NK1 or NK2 receptors.	Capsaicin	32-41	pulmonary adenoma resistance 2	Mus musculus	66-70
15996639-9	2005	Dopamine D2 receptor knockout animals were more sensitive to mechanical stimulation of the hindpaws than wild-type animals both in the baseline condition and following development of capsaicin-induced referred hypersensitivity in the hindpaws.	Capsaicin	183-192	dopamine receptor D2	Mus musculus	0-20
16133936-12	2005	Capsaicin, the most potent activator of the TRPV1 channel, evoked a fast inactivating Ca2+ transient suggesting the presence of endogenous TRPV1 channels in Neuro2a cells.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	44-49
16133936-12	2005	Capsaicin, the most potent activator of the TRPV1 channel, evoked a fast inactivating Ca2+ transient suggesting the presence of endogenous TRPV1 channels in Neuro2a cells.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	139-144
16133936-15	2005	Our data show co-activation of the P2Y2 receptor and capsaicin sensitive TRPV1 channel by ATP.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
16002371-0	2005	Changes in levels of nerve growth factor in nasal secretions after capsaicin inhalation in patients with airway symptoms from scents and chemicals.	Capsaicin	67-76	nerve growth factor	Homo sapiens	21-40
16096187-1	2005	Topical capsaicin is well known to reduce nociceptive pain and neurogenic inflammation by depleting substance P.	Capsaicin	8-17	tachykinin precursor 1	Homo sapiens	100-111
16006975-11	2005	Activation of tachykinin NK3 receptors located in the bladder can induce bladder overactivity at least in part via the activation of capsaicin sensitive C-fiber afferents, while tachykinin NK3 receptor activation in the spinal cord can inhibit the micturition reflex through an opioid mechanism.	Capsaicin	133-142	tachykinin receptor 3	Rattus norvegicus	25-37
16115206-7	2005	TRPC4 transcripts are also detected in capsaicin-sensitive dorsal root ganglia neurons.	Capsaicin	39-48	transient receptor potential cation channel, subfamily C, member 4	Rattus norvegicus	0-5
15907794-11	2005	We found that this leakage was enhanced by capsaicin and was antagonized by capsazepine, a capsaicin blocker, indicating that leakage of Ca2+ occurs through a channel composed of VR1.	Capsaicin	43-52	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	179-182
15907794-11	2005	We found that this leakage was enhanced by capsaicin and was antagonized by capsazepine, a capsaicin blocker, indicating that leakage of Ca2+ occurs through a channel composed of VR1.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	179-182
15978575-2	2005	The present paper characterizes the effects of JYL1421 (SC0030), a TRPV1 receptor antagonist, on capsaicin-evoked responses both in vitro and in vivo in the rat.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-72
16002371-7	2005	After capsaicin provocation, the patients showed a significant increase in NGF (p < 0.01), which was related to capsaicin cough sensitivity.	Capsaicin	6-15	nerve growth factor	Homo sapiens	75-78
16002371-7	2005	After capsaicin provocation, the patients showed a significant increase in NGF (p < 0.01), which was related to capsaicin cough sensitivity.	Capsaicin	115-124	nerve growth factor	Homo sapiens	75-78
16041554-1	2005	Vanilloid receptor type 1 (TRPV1) is expressed in a capsaicin-sensitive and peptide-containing sub-population of primary sensory nerves that in the rat stomach seems involved in regulation of chlorhydropeptic secretion and gastroprotection.	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
15936881-2	2005	It is suggested that phosphorylation of NR1 (pNR1) contributes to central sensitization after intradermal capsaicin injection.	Capsaicin	106-115	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	40-43
15947686-7	2005	RESULTS: SP and intravesical capsaicin increased the total amount of MIF in ILF.	Capsaicin	29-38	macrophage migration inhibitory factor	Rattus norvegicus	69-72
15947686-9	2005	SP and capsaicin differentially increased the MIF bands.	Capsaicin	7-16	macrophage migration inhibitory factor	Rattus norvegicus	46-49
15947686-13	2005	Although SP and capsaicin increased the total amount of MIF detected by enzyme-linked immunosorbent assay in ILF, the patterns of MIF complexes elicited by these 2 treatments were different.	Capsaicin	16-25	macrophage migration inhibitory factor	Rattus norvegicus	56-59
15837818-2	2005	Activation of TRPV1 contributes to the pronociceptive effects of capsaicin, protons, heat, and various endogenous lipid agonists such as anandamide and N-arachidonoyl-dopamine.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
15837819-1	2005	The vanilloid receptor transient receptor potential type V1 (TRPV1) integrates responses to multiple stimuli, such as capsaicin, acid, heat, and endovanilloids and plays an important role in the transmission of inflammatory pain.	Capsaicin	118-127	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
15837819-3	2005	A-425619 was found to potently block capsaicin-evoked increases in intracellular calcium concentrations in HEK293 cells expressing recombinant human TRPV1 receptors (IC50 = 5 nM).	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
16118913-1	2005	OBJECTIVE: Capsaicin, which acts by binding to the vanilloid receptor-1 (VR1), has been shown to give protection against gastric mucosal injury and to enhance healing of gastric ulcers.	Capsaicin	11-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-71
16118913-1	2005	OBJECTIVE: Capsaicin, which acts by binding to the vanilloid receptor-1 (VR1), has been shown to give protection against gastric mucosal injury and to enhance healing of gastric ulcers.	Capsaicin	11-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-76
15931076-3	2005	Further, such a manipulation modified the sensitivity to the TRPV1 receptor-antagonist capsazepine and altered the dependence of the capsaicin effect on extracellular pH.	Capsaicin	133-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
15969937-4	2005	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	65-96
15883036-1	2005	The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-27
15883036-1	2005	The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
15883036-1	2005	The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel.	Capsaicin	54-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-27
15883036-1	2005	The vanilloid receptor (VR1 or TRPV1) is a capsaicin (CAP)-sensitive non-selective cation channel.	Capsaicin	54-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
15882787-3	2005	We measured transient receptor potential vanilloid receptor 1 (TRPV1) responses to capsaicin (CAPS) in dorsal root ganglion (DRG) neurons (L4-S3) from normal cats and cats with FIC.	Capsaicin	83-92	transient receptor potential channel vanilloid subfamily member-1	Felis catus	12-61
15882787-3	2005	We measured transient receptor potential vanilloid receptor 1 (TRPV1) responses to capsaicin (CAPS) in dorsal root ganglion (DRG) neurons (L4-S3) from normal cats and cats with FIC.	Capsaicin	83-92	transient receptor potential channel vanilloid subfamily member-1	Felis catus	63-68
15882787-3	2005	We measured transient receptor potential vanilloid receptor 1 (TRPV1) responses to capsaicin (CAPS) in dorsal root ganglion (DRG) neurons (L4-S3) from normal cats and cats with FIC.	Capsaicin	94-98	transient receptor potential channel vanilloid subfamily member-1	Felis catus	12-61
15882787-3	2005	We measured transient receptor potential vanilloid receptor 1 (TRPV1) responses to capsaicin (CAPS) in dorsal root ganglion (DRG) neurons (L4-S3) from normal cats and cats with FIC.	Capsaicin	94-98	transient receptor potential channel vanilloid subfamily member-1	Felis catus	63-68
15821751-2	2005	2 In G3, vasorelaxation to THC was inhibited by pertussis toxin, but was unaffected by the CB1 receptor antagonist, AM251 (1 microM), incubation with the TRPV1 receptor agonist capsaicin (10 microM, 1 h), the TRPV1 receptor antagonist capsazepine (10 microM) or de-endothelialisation.	Capsaicin	177-186	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	154-159
15802291-7	2005	These results suggest that both the TRPV1 and P2X receptors mediate the sensory transduction of ROS, especially H2O2 and .OH, by capsaicin-sensitive vagal lung afferent fibres.	Capsaicin	129-138	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	36-41
15969937-4	2005	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	98-102
15969937-4	2005	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	108-119
15854744-1	2005	Capsaicin opens the TRPV1 channel, a cation channel that depolarizes and activates nociceptive neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	20-25
15918882-10	2005	Virus-induced gene silencing of AT3 resulted in a decrease in the accumulation of capsaicinoids, a phenotype consistent with pun1.	Capsaicin	82-95	ataxin 3	Homo sapiens	32-35
15854744-2	2005	Following this initial activation, neurons become desensitized to subsequent applications of capsaicin as well as to other noxious stimuli, a phenomenon attributed primarily to the entry of Ca2+ ions through the open TRPV1 channel.	Capsaicin	93-102	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	217-222
15722382-1	2005	BACKGROUND: TRPV1 is a ligand-gated ion channel whose activation by capsaicin increases intracellular Ca(2+) ([Ca(2+)](i)).	Capsaicin	68-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
15913603-5	2005	Addition of capsaicin, (R)-methanandamide and resiniferatoxin to prostate cells induced a dose-dependent increase in the intracellular calcium concentration that was reversed by the vanilloid TRPV1 receptor antagonist capsazepine.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	192-197
15746091-13	2005	Stimulation of TRPV1 by capsaicin down-regulates VACCs by dephosphorylation through Ca(2+)-dependent activation of calcineurin.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	15-20
15653710-1	2005	This study was carried out to determine the effect of 2-aminoethoxydiphenyl borate (2-APB), a common activator of transient receptor potential vanilloid (TRPV) type 1, 2, and 3 channels, on cardiorespiratory reflexes, pulmonary C fiber afferents, and isolated pulmonary capsaicin-sensitive neurons.	Capsaicin	270-279	arginyl aminopeptidase	Rattus norvegicus	86-89
15653710-3	2005	After perineural treatment of both cervical vagi with capsaicin to block the conduction of C fibers, 2-APB no longer evoked any of these reflex responses.	Capsaicin	54-63	arginyl aminopeptidase	Rattus norvegicus	103-106
15653710-5	2005	The stimulation of C fibers by 2-APB was attenuated but not abolished by capsazepine, a selective antagonist of the TRPV1, which completely blocked the response to capsaicin in these C fiber afferents.	Capsaicin	164-173	arginyl aminopeptidase	Rattus norvegicus	33-36
15653710-5	2005	The stimulation of C fibers by 2-APB was attenuated but not abolished by capsazepine, a selective antagonist of the TRPV1, which completely blocked the response to capsaicin in these C fiber afferents.	Capsaicin	164-173	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	116-121
15653710-6	2005	In isolated pulmonary capsaicin-sensitive neurons, 2-APB concentration dependently evoked an inward current that was partially inhibited by capsazepine but almost completely abolished by ruthenium red, an effective blocker of all TRPV channels.	Capsaicin	22-31	arginyl aminopeptidase	Rattus norvegicus	53-56
15653710-7	2005	In conclusion, 2-APB evokes a consistent and distinct stimulatory effect on pulmonary C fibers in vivo and on isolated pulmonary capsaicin-sensitive neurons in vitro.	Capsaicin	129-138	arginyl aminopeptidase	Rattus norvegicus	17-20
15722382-14	2005	Whilst capsaicin activated TRPV1 and Delta(9)-tetrahydrocannabinol activated CB(1), anandamide is an endogenous agonist for both receptor systems.	Capsaicin	7-16	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
15857679-1	2005	The vanilloid receptor (TRPV1 or VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid, and high temperature.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
15887113-1	2005	BACKGROUND & AIMS: Clostridium difficile toxin A is a potent intestinal inflammatory agent that has been shown to act at least partially by neurogenic mechanisms involving activation of the transient receptor potential vanilloid 1 (TRPV1) (capsaicin) receptor.	Capsaicin	244-253	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	236-241
15836968-8	2005	The inflammation-induced increase in capsaicin- and proton-responsiveness was entirely mediated by TRPV1 because IB4-positive neurons from inflamed TRPV1-/- mice were capsaicin-insensitive and unaltered in proton-responsiveness.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	99-104
15836968-8	2005	The inflammation-induced increase in capsaicin- and proton-responsiveness was entirely mediated by TRPV1 because IB4-positive neurons from inflamed TRPV1-/- mice were capsaicin-insensitive and unaltered in proton-responsiveness.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	148-153
15836968-8	2005	The inflammation-induced increase in capsaicin- and proton-responsiveness was entirely mediated by TRPV1 because IB4-positive neurons from inflamed TRPV1-/- mice were capsaicin-insensitive and unaltered in proton-responsiveness.	Capsaicin	167-176	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	99-104
15562294-3	2005	In brain slices, application of the TRPV1 receptor agonist capsaicin increased the firing rate of rat dopamine neurons and in a proportion of tested cells (44%) it also induced a bursting behavior.	Capsaicin	59-68	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	36-41
15808879-4	2005	The relaxant effect of capsaicin was strongly reduced in colonic preparations from transient receptor potential vanilloid type (TRPV1) receptor knockout mice as compared to their wildtype controls.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	128-133
15857679-1	2005	The vanilloid receptor (TRPV1 or VR1) is a molecular integrator of various painful stimuli, including capsaicin, acid, and high temperature.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	33-36
15823259-2	2005	We recently found that depletion of capsaicin-sensitive afferents by systemic treatment with a potent TRPV1 agonist, resiniferotoxin, in adult rats produces long-lasting paradoxical changes in mechanical and thermal sensitivities, which resemble the unique clinical features of postherpetic neuralgia.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	102-107
15878709-5	2005	Dog TRPV1 was activated by various known TRPV1 agonists in a concentration-dependent manner: Ag23 = resiniferatoxin > olvanil approximately arvanil > capsaicin > phorbol 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) > N-oleoyldopamine (OLDA).	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Canis lupus familiaris	4-9
15878709-5	2005	Dog TRPV1 was activated by various known TRPV1 agonists in a concentration-dependent manner: Ag23 = resiniferatoxin > olvanil approximately arvanil > capsaicin > phorbol 12-phenylacetate 13-acetate 20-homovanillate (PPAHV) > N-oleoyldopamine (OLDA).	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Canis lupus familiaris	41-46
15763167-2	2005	Studies involving systemic or intrahypothalamic capsaicin administration have suggested a role for TRPV1 in body temperature control.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	99-104
15774269-4	2005	L-732138 (NK1 receptor antagonist) or SR-48968 (NK2 receptor antagonist) pretreatment reduced capsaicin-enhanced hypotension, bronchoconstriction, plasma extravasation, and plasma NO level.	Capsaicin	94-103	tachykinin receptor 1	Rattus norvegicus	10-22
15774269-4	2005	L-732138 (NK1 receptor antagonist) or SR-48968 (NK2 receptor antagonist) pretreatment reduced capsaicin-enhanced hypotension, bronchoconstriction, plasma extravasation, and plasma NO level.	Capsaicin	94-103	tachykinin receptor 2	Rattus norvegicus	48-60
15774269-10	2005	In summary, NK1 and NK2 receptors and iNOS play a role in NO formation and on capsaicin-induced bronchoconstriction and plasma extravasation.	Capsaicin	78-87	nitric oxide synthase 2	Rattus norvegicus	38-42
15680472-5	2005	In this report, we describe a noninvasive pharmacodynamic model in which topical application of capsaicin is utilized to induce the release of endogenous CGRP and a vasodilatory response which can be measured using laser Doppler imaging.	Capsaicin	96-105	calcitonin-related polypeptide alpha	Rattus norvegicus	154-158
15691846-2	2005	TRPV1 exhibits desensitization in a Ca2+-dependent manner upon repeated activation by capsaicin or protons.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
15727576-3	2005	METHODS: The presence of secretoneurin in nasal biopsies and its release in response to nasal capsaicin and histamine challenges were examined.	Capsaicin	94-103	secretogranin II	Homo sapiens	25-38
15915217-3	2005	The TRPV1 channel can be activated by vanilloids such as capsaicin, as well as endogenous stimulators including H(+), heat, lipoxygenase products and anandamide.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
15793280-1	2005	The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-24
15793280-1	2005	The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-29
15793280-1	2005	The vanilloid receptor-1 (VR1, or transient receptor potential vanilloid-1 receptor, TRPV1) is activated by capsaicin, the key ingredient of hot peppers.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-90
15793280-6	2005	In organ culture, TRPV1 activation by capsaicin resulted in a dose-dependent and TRPV1-specific inhibition of hair shaft elongation, suppression of proliferation, induction of apoptosis, premature HF regression (catagen), and up-regulation of intrafollicular transforming growth factor-beta(2).	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
15793280-6	2005	In organ culture, TRPV1 activation by capsaicin resulted in a dose-dependent and TRPV1-specific inhibition of hair shaft elongation, suppression of proliferation, induction of apoptosis, premature HF regression (catagen), and up-regulation of intrafollicular transforming growth factor-beta(2).	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
15781527-3	2005	In the present study, we clarify the capsaicin concentration dependency for development and maintenance of secondary mechanical allodynia and the role of spinal opioid receptor like1 (ORL1) receptor and N-methyl-D-aspartate receptor in the development and maintenance of secondary mechanical allodynia induced by an intradermal capsaicin injection.	Capsaicin	328-337	opioid related nociceptin receptor 1	Rattus norvegicus	184-188
15918513-1	2005	A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-25
15918513-1	2005	A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
15918513-1	2005	A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants.	Capsaicin	111-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-25
15918513-1	2005	A vanilloid receptor (VR1, now known as TRPV1) is an ion channel activated by vanilloids, including capsaicin (CAP) and resiniferatoxin (RTX), which are pungent ingredients of plants.	Capsaicin	111-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
15836712-0	2005	Calcitonin gene-related peptide released by capsaicin suppresses myoelectrical activity of gastric smooth muscle.	Capsaicin	44-53	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
15869474-4	2005	Activation of peripheral nociceptors in vivo using intraplantar injections of capsaicin in anaesthetized rats induced a rapid onset and time-dependent increase in p-Akt Ser 473 in small- and medium-sized DRG, predominantly TRPV1-positive neurons.	Capsaicin	78-87	AKT serine/threonine kinase 1	Rattus norvegicus	165-168
15869474-4	2005	Activation of peripheral nociceptors in vivo using intraplantar injections of capsaicin in anaesthetized rats induced a rapid onset and time-dependent increase in p-Akt Ser 473 in small- and medium-sized DRG, predominantly TRPV1-positive neurons.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	223-228
15836712-7	2005	Intragastric capsaicin administration caused a significant release of substance P (SP) and calcitonin gene-related peptide (CGRP).	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	91-122
15836712-7	2005	Intragastric capsaicin administration caused a significant release of substance P (SP) and calcitonin gene-related peptide (CGRP).	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	124-128
15836712-10	2005	Continuous CGRP-(8-37) infusion into the gastric artery completely blocked the reduction by intragastric capsaicin of myoelectrical activity.	Capsaicin	105-114	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
15836712-11	2005	CONCLUSION: These results suggest that the suppression of the myoelectrical activity of gastric smooth muscle by capsaicin is attributable to the endogenous CGRP released.	Capsaicin	113-122	calcitonin-related polypeptide alpha	Rattus norvegicus	157-161
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	amelogenin X-linked	Homo sapiens	0-3
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	83-88
15615864-5	2005	AMG 9810 blocks capsaicin-evoked depolarization and calcitonin gene-related peptide release in cultures of rat dorsal root ganglion primary neurons.	Capsaicin	16-25	amelogenin X-linked	Homo sapiens	0-3
15615864-7	2005	In vivo, AMG 9810 is effective at preventing capsaicin-induced eye wiping in a dose-dependent manner, and it reverses thermal and mechanical hyperalgesia in a model of inflammatory pain induced by intraplantar injection of complete Freund"s adjuvant.	Capsaicin	45-54	amelogenin X-linked	Homo sapiens	9-12
15579495-7	2005	Increased levels of tumor necrosis factor (TNF)-alpha, interleukin (IL)-6, IL-10, and leukotriene B4 in BAL fluid as well as higher expression of cytokine-induced neutrophil chemoattractant (CINC)-3 in lung homogenates were detected in the capsaicin group compared with vehicle group.	Capsaicin	240-249	C-X-C motif chemokine ligand 2	Rattus norvegicus	146-198
15579495-8	2005	In the capsaicin group, chronic treatment with compound 48/80 restored the TNF-alpha levels to control values and prevented the neutrophil influx in BAL fluid.	Capsaicin	7-16	tumor necrosis factor	Rattus norvegicus	75-84
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-117
15579495-10	2005	In conclusion, chronic neuropeptide depletion promoted by neonatal capsaicin treatment up-regulates airways mast cells, which upon activation by antigen at adult ages, release large amounts of cytokines such as TNF-alpha and CINC-3 that accounts for the massive airways neutrophil infiltration.	Capsaicin	67-76	tumor necrosis factor	Rattus norvegicus	211-220
15615864-9	2005	AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.	Capsaicin	67-76	amelogenin X-linked	Homo sapiens	0-3
15615864-9	2005	AMG 9810 is the first cinnamide TRPV1 antagonist reported to block capsaicin-induced eye wiping behavior and reverse hyperalgesia in an animal model of inflammatory pain.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-37
15579495-10	2005	In conclusion, chronic neuropeptide depletion promoted by neonatal capsaicin treatment up-regulates airways mast cells, which upon activation by antigen at adult ages, release large amounts of cytokines such as TNF-alpha and CINC-3 that accounts for the massive airways neutrophil infiltration.	Capsaicin	67-76	C-X-C motif chemokine ligand 2	Rattus norvegicus	225-231
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-117
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-117
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-117
15615864-4	2005	AMG 9810 is a competitive antagonist of capsaicin activation (IC50 value for human TRPV1, 24.5 +/- 15.7 nM; rat TRPV1, 85.6 +/- 39.4 nM) and blocks all known modes of TRPV1 activation, including protons (IC50 value for rat TRPV1, 294 +/- 192 nM; human TRPV1, 92.7 +/- 72.8 nM), heat (IC50 value for rat TRPV1, 21 +/- 17 nM; human TRPV1, 15.8 +/- 10.8 nM), and endogenous ligands, such as anandamide, N-arachidonyl dopamine, and oleoyldopamine.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
15781048-0	2005	Capsaicin- and anandamide-induced gastric acid secretion via vanilloid receptor type 1 (TRPV1) in rat brain.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	88-93
15833551-0	2005	Gene gun particle encoding preproenkephalin cDNA produces analgesia against capsaicin-induced bladder pain in rats.	Capsaicin	76-85	proenkephalin	Homo sapiens	27-43
15833551-1	2005	OBJECTIVES: To evaluate the efficacy of gene therapy using a gene gun or direct injection for the transfer of human preproenkephalin (PPE) plasmid cDNA using a capsaicin-induced bladder pain model in rats.	Capsaicin	160-169	proenkephalin	Homo sapiens	134-137
15644492-6	2005	By probing human and rat brain cDNA libraries to identify TRPV subunits, we identified a novel human TRPV1 RNA splice variant, TRPV1b, which forms functional ion channels that are activated by temperature (threshold, approximately 47 degrees C), but not by capsaicin or protons.	Capsaicin	257-266	transient receptor potential cation channel subfamily V member 1	Homo sapiens	101-106
15782105-7	2005	RESULTS: Intravenous injection of the TRPV-1 agonist capsaicin induced a dose-dependent increase in Evans blue accumulation in the rat pancreas (P < 0.05 vs. vehicle control).	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	38-44
15781048-1	2005	The activation of transient receptor potential vanilloid receptor 1 (TRPV1) by capsaicin in rat brain stimulates gastric acid secretion via tachykinin NK2 receptors and the vagus cholinergic nerve, but the involvement of other receptor systems has not been elucidated.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-67
15781048-1	2005	The activation of transient receptor potential vanilloid receptor 1 (TRPV1) by capsaicin in rat brain stimulates gastric acid secretion via tachykinin NK2 receptors and the vagus cholinergic nerve, but the involvement of other receptor systems has not been elucidated.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-74
15781048-9	2005	injection of anandamide (an endogenous ligand of TRPV1 and cannabinoid receptors, 30 and 100 nmol) stimulated gastric acid secretion, and the response was inhibited by an antagonist of TRPV1 and in the capsaicin-treated rats, but not by an antagonist of cannabinoid receptors.	Capsaicin	202-211	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-54
15781048-10	2005	In conclusion, the TRPV1 system, which is activated by capsaicin and anandamide, is preferentially coupled with non-NMDA and GABA(A) receptor systems in the brain and stimulates gastric acid secretion in rats.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	19-24
15781052-5	2005	Capsaicin-stimulated release of CGRP and SP was 48% and 58% lower in acid- than in saline-treated animals, indicating that capsaicin-sensitive fibers in the dorsal spinal cord were already partially depleted by acid treatment.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	32-36
15781052-7	2005	Gastric origin and capsaicin sensitivity of glutamatergic, CGRP- and SP-containing primary afferents in thoracic dorsal root ganglia were then determined by retrograde tracing with True Blue and immunohistochemical labeling with the vanilloid receptor TRPV1.	Capsaicin	19-28	calcitonin related polypeptide alpha	Homo sapiens	59-63
15781052-10	2005	We conclude that noxious gastric stimulation with acid induces release of glutamate, SP, and CGRP from capsaicin-sensitive sensory afferents in the dorsal horn of the spinal cord where they may play an important role in gastric nociception and hyperalgesia.	Capsaicin	103-112	calcitonin related polypeptide alpha	Homo sapiens	93-97
15764707-0	2005	A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.	Capsaicin	60-69	C-C motif chemokine ligand 3	Homo sapiens	29-33
15764707-0	2005	A proinflammatory chemokine, CCL3, sensitizes the heat- and capsaicin-gated ion channel TRPV1.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
15764707-4	2005	In these cells, capsaicin and anandamide induced Ca(2+) influx mediated by TRPV1.	Capsaicin	16-25	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-80
15764707-9	2005	Pretreatment with CCL3 enhanced the response of DRG neurons to capsaicin or anandamide.	Capsaicin	63-72	C-C motif chemokine ligand 3	Homo sapiens	18-22
15692058-7	2005	SSP-saporin treatment also decreased c-fos expression in the dorsal horn of the spinal cord induced by instillation of capsaicin into the bladder.	Capsaicin	119-128	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
15557084-7	2005	Capsazepine was also observed to reverse cumulative responses to 20-HETE and capsaicin, a TRPV1 agonist.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	90-95
15715923-2	2005	The TRPV1 channel, a member of the TRPV sub-family, is identified by expression cloning using the "hot" pepper-derived vanilloid compound capsaicin as a ligand.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
15715923-2	2005	The TRPV1 channel, a member of the TRPV sub-family, is identified by expression cloning using the "hot" pepper-derived vanilloid compound capsaicin as a ligand.	Capsaicin	138-147	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
15715923-6	2005	Regarding the latter, these neurons release stored neuropeptides through a calcium-dependent mechanism via the binding of capsaicin to VR1.	Capsaicin	122-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	135-138
15689199-4	2005	GTN (2 and 50 microg/kg/min) or NONOate infusion (25 nmol/kg/min) did not cause any CGRP release during and shortly after infusion, whereas administration of capsaicin resulted in strongly increased CGRP levels.	Capsaicin	158-167	calcitonin-related polypeptide alpha	Rattus norvegicus	199-203
15689199-5	2005	GTN infusion (2 microg/kg/min for 30 min) did not lead to enhanced c-fos LI after 2 h and 4 h, whereas capsaicin infusion caused a time- and dose-dependent expression of c-fos LI within laminae I and II of the TNC.	Capsaicin	103-112	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	170-175
15689199-6	2005	Surprisingly, GTN attenuated capsaicin-induced c-fos expression by 64%.	Capsaicin	29-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	47-52
15689199-7	2005	The nitric oxide synthase (NOS) inhibitor L-NAME (5 and 50 mg/kg) reduced capsaicin-induced c-fos LI dose dependently (reduction by 13% and 59%).	Capsaicin	74-83	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	92-97
15689199-10	2005	Both GTN and L-NAME reduced capsaicin-induced c-fos LI.	Capsaicin	28-37	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	46-51
15689199-11	2005	This is most likely due to a feedback inhibition of nitric oxide synthases, which indicates that the c-fos response to capsaicin within TNC is mediated by NO dependent mechanisms.	Capsaicin	119-128	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	101-106
15689158-1	2005	Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores were synthesized, and their in vitro activity in blocking capsaicin activation of TRPV1 was assessed.	Capsaicin	186-195	transient receptor potential cation channel subfamily V member 1	Homo sapiens	6-46
15721164-7	2005	Results indicate there was a dose-dependent reduction in capsaicin-induced mechanical hypersensitivity for all mGlu receptor agents; with maximal increases in mechanical thresholds that were 7-fold for AIDA and APDC, 7.5-fold for L-AP4 and 5.6-fold for MPEP.	Capsaicin	57-66	axin interactor, dorsalization associated	Rattus norvegicus	202-206
15649425-6	2005	These results suggest that dietary phytochemicals, such as capsaicin, curcumin, [6]-gingerol, and resveratrol, have inhibitory effects on P-glycoprotein and potencies to cause drug-food interactions.	Capsaicin	59-68	ATP binding cassette subfamily B member 1	Homo sapiens	138-152
15483069-0	2005	Nicotinic AChR in subclassified capsaicin-sensitive and -insensitive nociceptors of the rat DRG.	Capsaicin	32-41	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	10-14
15750287-4	2005	Treatment of DRG cells with 100 nM bradykinin for 3 h potentiated capsaicin-induced SPLI release accompanied with the induction of cyclooxygenase-2 mRNA expression.	Capsaicin	66-75	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	131-147
15750287-7	2005	These results suggest that CB(1) could inhibit either the capsaicin-induced Ca(2+) influx or the potentiation of capsaicin-induced SPLI release by a long-term treatment with bradykinin through involvement of a cyclic-AMP-dependent PKA pathway.	Capsaicin	113-122	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	231-234
15582720-3	2005	Pretreatment of rats with capsaicin almost completely depleted cardiac CGRP stores; however, suppression of norepinephrine release by 30 min of low flow ischemia was not affected.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	71-75
15689158-1	2005	Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores were synthesized, and their in vitro activity in blocking capsaicin activation of TRPV1 was assessed.	Capsaicin	186-195	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
15689158-1	2005	Novel transient receptor potential vanilloid 1 (TRPV1) receptor antagonists with various bicyclic heteroaromatic pharmacophores were synthesized, and their in vitro activity in blocking capsaicin activation of TRPV1 was assessed.	Capsaicin	186-195	transient receptor potential cation channel subfamily V member 1	Homo sapiens	210-215
15733095-12	2005	In addition, bladder noxious input conveyed in vanilloid-resistant primary afferents is important to spinal ERK phosphorylation in both noninflamed and CYP-inflamed animals.	Capsaicin	47-56	Eph receptor B1	Rattus norvegicus	108-111
15650631-7	2005	In mechanistic studies, ablation of capsaicin-sensitive afferent neurons abolishes bombesin-induced gastroprotection while cyclo-oxygenase inhibition partially reverses this effect.	Capsaicin	36-45	gastrin releasing peptide	Homo sapiens	83-91
15549397-3	2005	Here, we have investigated the occurrence of the ligand-binding alpha-subunits of neuronal nAChR by means of reverse transcription/polymerase chain reaction and immunohistochemistry in the rat heart during prenatal and postnatal development and after capsaicin-induced sensory denervation.	Capsaicin	251-260	cholinergic receptor nicotinic epsilon subunit	Rattus norvegicus	91-96
15639479-9	2005	Capsaicin caused massive CGRP release in all mouse genotypes with the exception of TRPV1-/-.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	25-29
15671295-3	2005	The source of secretoneurin-positive nerves in the eye was established by measuring the concentration in eye tissues, the trigeminal and superior cervical ganglia both in control rats and in rats treated with capsaicin, and by performing immunofluorescence in one rat subjected to sympathectomy.	Capsaicin	209-218	secretogranin II	Homo sapiens	14-27
15671295-11	2005	CONCLUSIONS: Apart from the sympathetically innervated dilator muscle, there is unequivocal evidence that secretoneurin represents a constituent of capsaicin-sensitive sensory neurons in the rat trigeminal ganglion and of unmyelinated C-fibers in the rat iris/ciliary body complex, which indicates a participation of this peptide in the ocular irritative response, a model for neurogenic inflammation in lower mammals.	Capsaicin	148-157	secretogranin II	Homo sapiens	106-119
15385593-1	2005	Low doses of cannabinoids applied intrathecally attenuate capsaicin-evoked heat and mechanical hyperalgesia via CB1 receptors.	Capsaicin	58-67	cannabinoid receptor 1	Rattus norvegicus	112-115
15647820-18	2005	Capsaicin treatment destroyed 57% of the unmyelinated sensory axons, reduced the substance P and CGRP content in the sciatic nerve and proximal tibia, and inhibited neurogenic extravasation.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	97-101
15492487-6	2005	The present results demonstrate that both 3beta-HSD and TRPV1 are markers for neurodegeneration and neuroregeneration in capsaicin-sensitive primary afferent neurons, and that NGF is an effective tool to induce recovery after peripheral nerve injury.	Capsaicin	121-130	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	42-51
15356216-0	2005	Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.	Capsaicin	39-51	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-109
15356216-0	2005	Development of the first ultra-potent "capsaicinoid" agonist at transient receptor potential vanilloid type 1 (TRPV1) channels and its therapeutic potential.	Capsaicin	39-51	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	111-116
15492487-0	2005	Differential regulation of 3-beta-hydroxysteroid dehydrogenase and vanilloid receptor TRPV1 mRNA in sensory neurons by capsaicin and NGF.	Capsaicin	119-128	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	86-91
15492487-1	2005	It was the aim of the present study to investigate by RT-PCR the regulation of the mRNA of the neurosteroid-synthesizing enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and of the vanilloid receptor TRPV1 in dorsal root ganglia (DRGs) of rats during the process of capsaicin denervation of primary sensory neurons and the following regeneration.	Capsaicin	271-280	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	128-162
15492487-1	2005	It was the aim of the present study to investigate by RT-PCR the regulation of the mRNA of the neurosteroid-synthesizing enzyme 3beta-hydroxysteroid dehydrogenase (3beta-HSD) and of the vanilloid receptor TRPV1 in dorsal root ganglia (DRGs) of rats during the process of capsaicin denervation of primary sensory neurons and the following regeneration.	Capsaicin	271-280	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	164-173
15492487-2	2005	The expression of 3beta-HSD in DRG was increased 3 days after the capsaicin treatment, and it remained at that level during a 22 day observation period.	Capsaicin	66-75	hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 1	Rattus norvegicus	18-27
15492487-3	2005	The expression of TRPV1, a specific marker of capsaicin-sensitive small sensory neurons connected to C- and Adelta-fibers, was markedly reduced 3 days after the capsaicin treatment.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-23
15492487-3	2005	The expression of TRPV1, a specific marker of capsaicin-sensitive small sensory neurons connected to C- and Adelta-fibers, was markedly reduced 3 days after the capsaicin treatment.	Capsaicin	161-170	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-23
15645129-6	2005	Moreover, inhibitors of protein kinase C (PKC), 7-hydroxystaurosporin (UCN-01; 100 nM) and chelerythrine (0.5 microM), significantly decreased HL-60 cell differentiation induced by the combination of TPA and capsaicin.	Capsaicin	208-217	proline rich transmembrane protein 2	Homo sapiens	24-40
15645129-6	2005	Moreover, inhibitors of protein kinase C (PKC), 7-hydroxystaurosporin (UCN-01; 100 nM) and chelerythrine (0.5 microM), significantly decreased HL-60 cell differentiation induced by the combination of TPA and capsaicin.	Capsaicin	208-217	proline rich transmembrane protein 2	Homo sapiens	42-45
15645129-7	2005	These results suggest that PKC may be involved in HL-60 cell differentiation induced by TPA in combination with capsaicin.	Capsaicin	112-121	proline rich transmembrane protein 2	Homo sapiens	27-30
15631885-1	2005	We have previously reported that intradermal capsaicin injection causes the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein (CREB) in the spinal cord of rats.	Capsaicin	45-54	cAMP responsive element binding protein 1	Rattus norvegicus	95-160
15631885-1	2005	We have previously reported that intradermal capsaicin injection causes the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein (CREB) in the spinal cord of rats.	Capsaicin	45-54	cAMP responsive element binding protein 1	Rattus norvegicus	162-166
15631885-2	2005	The present study was designed to investigate the role of calcium/camodulin protein dependent protein kinase II (CaM kinase II) in the regulation of phosphorylation of CREB after capsaicin injection.	Capsaicin	179-188	cAMP responsive element binding protein 1	Rattus norvegicus	168-172
15631885-3	2005	We found that capsaicin injection produces a significant upregulation of phosphorylated CREB in the spinal cord of rat.	Capsaicin	14-23	cAMP responsive element binding protein 1	Rattus norvegicus	88-92
15492487-6	2005	The present results demonstrate that both 3beta-HSD and TRPV1 are markers for neurodegeneration and neuroregeneration in capsaicin-sensitive primary afferent neurons, and that NGF is an effective tool to induce recovery after peripheral nerve injury.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	97-106	nerve growth factor	Rattus norvegicus	23-26
15708075-2	2005	Functional capsaicin TRPV1 receptors have been demonstrated in urothelial cells of rodent urinary bladder, and TRPV1-knockout mice exhibit diminished nitric oxide and stretch-evoked adenosine triphosphate release from urothelial cells.	Capsaicin	11-20	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	21-26
15708076-10	2005	This reflex was sensitive to ganglion blockade or capsaicin-sensitive C-fiber deafferentation and might be mediated by C-fiber activation through TRPM8.	Capsaicin	50-59	transient receptor potential cation channel subfamily M member 8	Cavia porcellus	146-151
15673679-3	2005	Here we show that responses to capsaicin or inflammatory pain were significantly reduced in mice lacking glutamate receptor 5 (GluR5) but not GluR6 subunits.	Capsaicin	31-40	glutamate receptor, ionotropic, kainate 1	Mus musculus	105-125
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	97-106	glial cell derived neurotrophic factor	Rattus norvegicus	31-35
15673679-3	2005	Here we show that responses to capsaicin or inflammatory pain were significantly reduced in mice lacking glutamate receptor 5 (GluR5) but not GluR6 subunits.	Capsaicin	31-40	glutamate receptor, ionotropic, kainate 1	Mus musculus	127-132
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	97-106	calcitonin-related polypeptide alpha	Rattus norvegicus	120-151
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	97-106	calcitonin-related polypeptide alpha	Rattus norvegicus	153-157
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	108-111	nerve growth factor	Rattus norvegicus	23-26
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	108-111	glial cell derived neurotrophic factor	Rattus norvegicus	31-35
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	108-111	calcitonin-related polypeptide alpha	Rattus norvegicus	120-151
15667652-7	2005	Chronic treatment with NGF and GDNF significantly and concentration-dependently increased 100 nM capsaicin (CAP)-evoked calcitonin gene-related peptide (CGRP) release, reaching approximately 300% at the highest concentration tested (100 ng/ml).	Capsaicin	108-111	calcitonin-related polypeptide alpha	Rattus norvegicus	153-157
15667652-9	2005	Utilizing immunohistochemistry to account for the proportions of TRPV1- or CGRP-positive neurons under each growth factor treatment condition and then standardizing evoked CGRP release to these proportions, we observed that NGF was much more effective in enhancing CAP- and 50 mM K+-evoked CGRP release than was GDNF.	Capsaicin	265-268	nerve growth factor	Rattus norvegicus	224-227
15659603-4	2005	We also found that CAP or AEA increased mitochondrial cytochrome c release as well as immunoreactivity to cleaved caspase-3 and that the caspase-3 inhibitor z-Asp-Glu-Val-Asp-fmk protected DA neurons from CAP- or AEA-induced neurotoxicity.	Capsaicin	19-22	caspase 3	Rattus norvegicus	114-123
15659603-4	2005	We also found that CAP or AEA increased mitochondrial cytochrome c release as well as immunoreactivity to cleaved caspase-3 and that the caspase-3 inhibitor z-Asp-Glu-Val-Asp-fmk protected DA neurons from CAP- or AEA-induced neurotoxicity.	Capsaicin	19-22	caspase 3	Rattus norvegicus	137-146
15659603-1	2005	Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry.	Capsaicin	113-122	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-77
15659603-1	2005	Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry.	Capsaicin	113-122	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
15659603-4	2005	We also found that CAP or AEA increased mitochondrial cytochrome c release as well as immunoreactivity to cleaved caspase-3 and that the caspase-3 inhibitor z-Asp-Glu-Val-Asp-fmk protected DA neurons from CAP- or AEA-induced neurotoxicity.	Capsaicin	205-208	caspase 3	Rattus norvegicus	137-146
15659603-1	2005	Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry.	Capsaicin	113-122	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	100-103
15659603-1	2005	Intranigral injection of the transient receptor potential vanilloid subtype 1 (TRPV1; also known as VR1) agonist capsaicin (CAP) into the rat brain, or treatment of rat mesencephalic cultures with CAP, resulted in cell death of dopaminergic (DA) neurons, as visualized by immunocytochemistry.	Capsaicin	124-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-77
15659603-7	2005	Surprisingly, CZP and AM251 reversed HU210- or CAP-induced neurotoxicity by inhibiting Ca2+ influx, respectively, suggesting the existence of functional cross talk between TRPV1 and CB1 receptors.	Capsaicin	47-50	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	172-177
15659603-7	2005	Surprisingly, CZP and AM251 reversed HU210- or CAP-induced neurotoxicity by inhibiting Ca2+ influx, respectively, suggesting the existence of functional cross talk between TRPV1 and CB1 receptors.	Capsaicin	47-50	cannabinoid receptor 1	Rattus norvegicus	182-185
15634002-4	2005	As a result of our screening efforts, we identified (E)-3-(4-tert-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (1), an antagonist that blocks the capsaicin-induced and pH-induced uptake of (45)Ca(2+) in TRPV1-expressing Chinese hamster ovary cells with IC(50) values of 17 +/- 5 and 150 +/- 80 nM, respectively.	Capsaicin	164-173	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	221-226
15513920-7	2005	Capsaicin-induced desensitization of VR1 was down-regulated, whereas VR1 re-sensitization was up-regulated in DRG neurons from diabetic rats.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-40
16173059-3	2005	TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin.	Capsaicin	197-206	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
15816527-6	2005	Capsaicin, at non-toxic amounts of 0.25 and 0.5 micromole/plate, expressed a dose-dependent inhibition of the mutagenicity of Glu-P-1 and PhIP when they are metabolically activated by rat, hamster and human liver S9 and of Trp-P-2 when activated by rat and hamster liver S9.	Capsaicin	0-9	polycystin 2, transient receptor potential cation channel	Homo sapiens	223-230
15655521-2	2005	Proteinase-activated receptor-2 (PAR(2)), expressed in capsaicin-sensitive sensory neurons, plays a protective role in gastric mucosa.	Capsaicin	55-64	coagulation factor II (thrombin) receptor-like 1	Mus musculus	0-31
15655521-2	2005	Proteinase-activated receptor-2 (PAR(2)), expressed in capsaicin-sensitive sensory neurons, plays a protective role in gastric mucosa.	Capsaicin	55-64	coagulation factor II (thrombin) receptor-like 1	Mus musculus	33-39
16259727-11	2005	Ghrelin-induced protection was abolished by vagotomy and significantly attenuated by L-NNA and deactivation of afferent nerves with neurotoxic dose of capsaicin.	Capsaicin	151-160	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
15816527-7	2005	In contrast, capsaicin enhanced the mutagenicity of Trp-P-2 in TA98 when incubated with human liver S9.	Capsaicin	13-22	polycystin 2, transient receptor potential cation channel	Homo sapiens	52-59
15665528-1	2005	In sensory neurons heat is transduced by a subfamily of TRP channels sharing sequence homology with the capsaicin-sensitive vanilloid receptor subtype 1 (TRPV1), but differing in their thermal response thresholds.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	124-152
15665528-1	2005	In sensory neurons heat is transduced by a subfamily of TRP channels sharing sequence homology with the capsaicin-sensitive vanilloid receptor subtype 1 (TRPV1), but differing in their thermal response thresholds.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	154-159
16101449-2	2005	TRPV1 is a ligand-gated, cation channel that is activated by heat, acid and capsaicin, a principal ingredient in hot peppers.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
16101449-7	2005	12-hydroperoxyeicosatetraenoic acid, an immediate metabolic product of 12-lipoxygenase, activates TRPV1 and shares 3-dimensional structural similarity with capsaicin.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	98-103
15289965-5	2005	Intramuscular injection of capsaicin (0.05 and 0.1%) produced a reduction in a MM-induced C1 neuronal activity in a dose-dependent manner and this effect was antagonized by pretreatment with an antagonist of VR1, capsazepine.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	208-211
16173059-1	2005	Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro-inflammatory cytokine production and cell death.	Capsaicin	85-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-36
16173059-1	2005	Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro-inflammatory cytokine production and cell death.	Capsaicin	85-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	38-41
16173059-1	2005	Activation of the capsaicin receptor (VR1 or TRPV1) in bronchial epithelial cells by capsaicinoids and other vanilloids promotes pro-inflammatory cytokine production and cell death.	Capsaicin	85-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-50
16173059-3	2005	TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin.	Capsaicin	197-206	interleukin 6	Homo sapiens	119-138
16173059-3	2005	TRPV1 antagonists and reduction of calcium concentrations in treatment solutions attenuated calcium flux, induction of interleukin-6 and 8 gene expression, and IL-6 secretion by cells treated with capsaicin or resiniferatoxin.	Capsaicin	197-206	interleukin 6	Homo sapiens	160-164
15655292-2	2005	The gastrointestinal protective effects of lafutidine are mediated by capsaicin-sensitive neurons, where capsaicin excites neurons by opening a member of the transient receptor potential channel family (TRPV1).	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	203-208
15655292-2	2005	The gastrointestinal protective effects of lafutidine are mediated by capsaicin-sensitive neurons, where capsaicin excites neurons by opening a member of the transient receptor potential channel family (TRPV1).	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	203-208
15621364-3	2005	Capsaicin injection induced phosphorylated-p38 (p-p38) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	0-9	mitogen-activated protein kinase 14	Homo sapiens	43-46
16165301-1	2005	TRPV1 gene disruption results in a loss of capsaicin and proton responsiveness, but has minimal effects on heat-induced nocifensive behavior, suggesting that sensory transduction of heat is independent of TRPV1.	Capsaicin	43-52	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
15893647-6	2005	Using subcellular fractionation of proteins and cross-linking of membrane proteins we have observed that intracolonic capsaicin induced a 50% increase in NKCC1 in the plasma membrane of lumbosacral spinal cord 90 and 180 min after instillation, in parallel with a similar decrease in the cytosolic fraction.	Capsaicin	118-127	solute carrier family 12, member 2	Mus musculus	154-159
15893647-8	2005	Intracolonic capsaicin also evoked a rapid (10 min) and transient phosphorylation of NKCC1, however, intracolonic saline did not produce significant changes in either NKCC1 trafficking or phosphorylation and none of the treatments induced any alterations of NKCC1 in the thoracic spinal cord.	Capsaicin	13-22	solute carrier family 12, member 2	Mus musculus	85-90
15630490-8	2005	AT significantly increased CGRP release from cultured dorsal root ganglion neurons isolated from rats in the presence of capsaicin.	Capsaicin	121-130	calcitonin-related polypeptide alpha	Rattus norvegicus	27-31
15561438-1	2005	TRPV2, a member of transient receptor potential ion channels, responds to high-threshold noxious heat, but neither to capsaicin nor to proton.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 2	Mus musculus	0-5
15630490-3	2005	We also demonstrated that activation of capsaicin-sensitive sensory neurons increased endothelial production of PGI2 by releasing calcitonin gene-related peptide (CGRP) in rats subjected to hepatic I/R.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	130-161
15630490-3	2005	We also demonstrated that activation of capsaicin-sensitive sensory neurons increased endothelial production of PGI2 by releasing calcitonin gene-related peptide (CGRP) in rats subjected to hepatic I/R.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	163-167
15621364-3	2005	Capsaicin injection induced phosphorylated-p38 (p-p38) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	0-9	mitogen-activated protein kinase 14	Homo sapiens	50-53
15621364-3	2005	Capsaicin injection induced phosphorylated-p38 (p-p38) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	126-135	mitogen-activated protein kinase 14	Homo sapiens	43-46
15621364-3	2005	Capsaicin injection induced phosphorylated-p38 (p-p38) in small-to-medium diameter sensory neurons with a peak at 2 min after capsaicin injection.	Capsaicin	126-135	mitogen-activated protein kinase 14	Homo sapiens	50-53
15621364-6	2005	Intrathecal administration of the p38 inhibitor, FR167653, reversed the thermal hyperalgesia produced by the capsaicin injection.	Capsaicin	109-118	mitogen-activated protein kinase 14	Homo sapiens	34-37
15621364-7	2005	Inhibition of p38 activation was confirmed by the decrease in the number of p-p38-IR neurons in the DRG following capsaicin injection.	Capsaicin	114-123	mitogen-activated protein kinase 14	Homo sapiens	14-17
15621364-7	2005	Inhibition of p38 activation was confirmed by the decrease in the number of p-p38-IR neurons in the DRG following capsaicin injection.	Capsaicin	114-123	mitogen-activated protein kinase 14	Homo sapiens	78-81
15471852-7	2004	1) Overexpression of PKCmu enhanced the response of rVR1 to capsaicin and low pH, and expression of a dominant negative variant of PKCmu reduced the response of rVR1.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-56
15471852-12	2004	6) Mutation of S116A in rVR1 blocked both the phosphorylation of rVR1 by PKCmu and the enhancement by PKCmu of the rVR1 response to capsaicin.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-28
15447941-1	2004	Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway wall.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
15447941-1	2004	Transient receptor potential vanniloid-1 (TRPV-1) mediates the cough response induced by the pepper extract capsaicin and is expressed in sensory nerves that innervate the airway wall.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-48
15447941-2	2004	We determined the expression of TRPV-1 in the airways of patients with chronic persistent cough of diverse causes and with an enhanced capsaicin cough response.	Capsaicin	135-144	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-38
15447941-5	2004	There was a significant correlation between capsaicin tussive response and the number of TRPV-1-positive nerves within the patients with cough.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-95
15459754-0	2004	Distinct thymocyte subsets express the vanilloid receptor VR1 that mediates capsaicin-induced apoptotic cell death.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-61
15492017-1	2004	As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-137
15492017-1	2004	As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	208-214
15492017-1	2004	As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	339-345
15492017-1	2004	As pretreatment with intraperitoneal capsaicin (8-methyl-N-vanillyl-6-nonenamide, CAP), an agonist of the vanilloid receptor known as VR1 or transient receptor potential channel-vanilloid receptor subtype 1 (TRPV-1), has been shown to block the first phase of lipopolysaccharide (LPS) fever in rats, this phase is thought to depend on the TRPV-1-bearing sensory nerve fibers originating in the abdominal cavity.	Capsaicin	48-80	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-137
15548432-7	2004	The effects of capsaicin, a specific agonist for TRPV1 receptors, were inhibited by capsazepine, but only weakly by CB1 or CB2 receptor antagonists.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
15548432-7	2004	The effects of capsaicin, a specific agonist for TRPV1 receptors, were inhibited by capsazepine, but only weakly by CB1 or CB2 receptor antagonists.	Capsaicin	15-24	cannabinoid receptor 1	Homo sapiens	116-119
15561387-5	2004	Intracolonic capsaicin induced a rapid (10 min) increase in GluR1, but not GluR2/3 in the synaptosomal membrane fraction which lasted at least 3 h and a decrease in GluR1 subunit in the cytosolic fraction.	Capsaicin	13-22	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	60-65
15578965-2	2004	Capsaicin receptor TRPV1 is a nociceptor-specific ion channel that serves as the molecular target of capsaicin.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
15578965-3	2004	TRPV1 can be activated not only by capsaicin but also by noxious heat (with a thermal threshold >43 degrees C) or protons (acidification), all of which are known to cause pain in vivo.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
15579007-3	2004	Small molecule agonists of VR1, including capsaicin and RTX, are currently utilized for a number of clinical syndromes, including intractable neuropathic pain, spinal detrusor hyperreflexia, and bladder hypersensitivity; however, antagonists of VR1 have yet to reach the clinic.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-30
15548449-11	2004	CONCLUSION: The present findings provide the evidence of the presence of TRPV1 on normal human urothelium where it could have important implications in the mechanism of action of intravesical vanilloids (capsaicin and resiniferatoxin).	Capsaicin	204-213	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
15337299-1	2004	Capsaicin, a pungent ingredient of chili pepper, activates vanilloid receptor subtype 1 (VR1), which is a nonselective cation channel with high Ca(2+) permeability.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	89-92
15337299-4	2004	Capsaicin at concentrations above 100 microM induced an increase in intracellular free Ca(2+) concentrations by influx from extracellular spaces, and the effect was blocked by capsazepine, a selective antagonist of VR1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	215-218
15337299-7	2004	VR1 in PC12 cells showed different characters from that in sensory neurons; capsaicin concentration-dependency and heat- and nerve growth factor-sensitivities.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-3
15549271-1	2004	Capsaicin-sensitive sensory nerves that contain calcitonin gene-related peptide (CGRP) contribute significantly to cardioprotective mechanisms.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	48-79
15549271-1	2004	Capsaicin-sensitive sensory nerves that contain calcitonin gene-related peptide (CGRP) contribute significantly to cardioprotective mechanisms.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	81-85
15549271-7	2004	Immunohistochemistry revealed a complete depletion of calcitonin gene-related peptide from cardiac sensory nerves after systemic capsaicin treatment.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	54-85
15561387-5	2004	Intracolonic capsaicin induced a rapid (10 min) increase in GluR1, but not GluR2/3 in the synaptosomal membrane fraction which lasted at least 3 h and a decrease in GluR1 subunit in the cytosolic fraction.	Capsaicin	13-22	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	165-170
15561387-6	2004	Capsaicin treatment also provoked CaMKII activation and pre-treatment with a specific CaMKII inhibitor prevented the GluR1 trafficking.	Capsaicin	0-9	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	117-122
15556833-4	2004	Pretreatment with the TRPV1 antagonist, capsazepine (10 microM) and ruthenium red (3 microM) significantly reduced the relaxation response to capsaicin by 78% (P<0.01) and 38% (P<0.05), respectively.	Capsaicin	142-151	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
15742997-0	2004	Ghrelin enhances gastric motility through direct stimulation of intrinsic neural pathways and capsaicin-sensitive afferent neurones in rats.	Capsaicin	94-103	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
15742997-3	2004	The present study was designed to investigate whether ghrelin accelerates gastric emptying via capsaicin-sensitive afferent neurones and directly affects the enteric neuromuscular function.	Capsaicin	95-104	ghrelin and obestatin prepropeptide	Rattus norvegicus	54-61
15742997-10	2004	Pretreatment with capsaicin prevented the ghrelin-induced acceleration of gastric emptying of nutrient solids.	Capsaicin	18-27	ghrelin and obestatin prepropeptide	Rattus norvegicus	42-49
15742997-13	2004	CONCLUSIONS: The results suggest that the stimulatory effects of ghrelin on gastric motility are mediated by direct stimulation of the enteric neural pathway and capsaicin-sensitive afferent neurones.	Capsaicin	162-171	ghrelin and obestatin prepropeptide	Rattus norvegicus	65-72
15556833-5	2004	Tetrodotoxin and calcitonin gene-related peptide (CGRP)-desensitization significantly reduced the response to capsaicin by 72% (P<0.01) and 42% (P<0.01), respectively.	Capsaicin	110-119	calcitonin-related polypeptide alpha	Rattus norvegicus	17-48
15556833-5	2004	Tetrodotoxin and calcitonin gene-related peptide (CGRP)-desensitization significantly reduced the response to capsaicin by 72% (P<0.01) and 42% (P<0.01), respectively.	Capsaicin	110-119	calcitonin-related polypeptide alpha	Rattus norvegicus	50-54
15520319-3	2004	Previous studies suggest that (1) capsaicin stimulates muscle metabosensitive vanilloid receptor subtype 1 (VR1), inducing a neurally mediated pressor response, and (2) activation of ATP-sensitive P2X receptors enhances the pressor response seen when muscle mechanoreceptors are engaged by muscle stretch.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-106
15388249-3	2004	The vanilloid olvanil reduces SM-induced edema and mRNA expression of cytokines and chemokines, suggesting that blocking the inflammatory effects of neuropeptides, such as substance P (SP), may provide protection against SM-induced dermal injury.	Capsaicin	4-13	tachykinin 1	Mus musculus	172-183
15388249-3	2004	The vanilloid olvanil reduces SM-induced edema and mRNA expression of cytokines and chemokines, suggesting that blocking the inflammatory effects of neuropeptides, such as substance P (SP), may provide protection against SM-induced dermal injury.	Capsaicin	4-13	tachykinin 1	Mus musculus	185-187
15388249-10	2004	This study demonstrates that SP expression could provide an additional endpoint for evaluating the effectiveness of vanilloid drugs on SM-induced skin inflammation.	Capsaicin	116-125	tachykinin 1	Mus musculus	29-31
15494172-4	2004	The inhibitory action of PS on the capsaicin-induced current may provide a basis for reducing capsaicin receptor-mediated nociception.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	94-112
15520319-3	2004	Previous studies suggest that (1) capsaicin stimulates muscle metabosensitive vanilloid receptor subtype 1 (VR1), inducing a neurally mediated pressor response, and (2) activation of ATP-sensitive P2X receptors enhances the pressor response seen when muscle mechanoreceptors are engaged by muscle stretch.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	108-111
15525465-6	2004	Pretreatment with ruthenium red (100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR1), blocked the effect of capsaicin on CBA.	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-95
15489017-1	2004	The Transient Receptor Potential cation channel V1 (TRPV1) is expressed in peripheral nociceptive neurons and is subject to polymodal activation via various agents including capsaicin, noxious heat, low extracellular pH, and direct phosphorylation by protein kinase C (PKC).	Capsaicin	174-183	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-50
15489017-1	2004	The Transient Receptor Potential cation channel V1 (TRPV1) is expressed in peripheral nociceptive neurons and is subject to polymodal activation via various agents including capsaicin, noxious heat, low extracellular pH, and direct phosphorylation by protein kinase C (PKC).	Capsaicin	174-183	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
15489017-6	2004	However, the antagonist capsazepine was only able to inhibit a capsaicin-evoked response of mTRPV1 with an IC50 of 1426+/-316 nM.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-98
15502055-10	2004	Small-dose capsaicin treatment increased antiinflammatory IL-10 levels and attenuated the increases in proinflammatory cytokines, NOx, and tissue MDA in septic rats.	Capsaicin	11-20	interleukin 10	Rattus norvegicus	58-63
15525465-6	2004	Pretreatment with ruthenium red (100 micromol/L), an antagonist of vanilloid receptor subtype 1 (VR1), blocked the effect of capsaicin on CBA.	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-100
15525465-9	2004	The facilitatory action of capsaicin may be attributed to the opening of K(ATP) channels mediated by VR1.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-104
15488288-7	2004	These findings, taken together, indicate that FK506 application on inflamed skin may activate nociceptive C-fibers, which bear bradykinin receptors and capsaicin-sensitive heat transducer of TRP family, TRPV1.	Capsaicin	152-161	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	203-208
15595420-0	2004	Decreased pain sensitivity of capsaicin-treated rats results from decreased VR1 expression.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	76-79
15220301-3	2004	Capsaicin depolarizes thin sensory afferent nerves that have vanilloid type 1 receptors (VR1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-92
15220301-9	2004	Anandamide (an endogenous substance that activates VR1) induced the same change in blood pressure as did capsaicin.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-54
15595419-7	2004	The capsaicin-induced apoptosis was blocked by the pretreatment with Z-VAD-fmk, a broad-range caspase inhibitor, or Ac-DEVD-CHO, a caspase-3 inhibitor.	Capsaicin	4-13	caspase 3	Mus musculus	131-140
15595419-8	2004	In addition to the caspase-3 activation, capsaicin also induced cytochrome c release and decrease in Bcl-2 protein expression with no changes in the level of Bax.	Capsaicin	41-50	B cell leukemia/lymphoma 2	Mus musculus	101-106
15201308-0	2004	A developmental switch in acute sensitization of small dorsal root ganglion (DRG) neurons to capsaicin or noxious heating by NGF.	Capsaicin	93-102	nerve growth factor	Rattus norvegicus	125-128
15201308-1	2004	Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development.	Capsaicin	182-191	nerve growth factor	Rattus norvegicus	90-109
15201308-1	2004	Using dissociated rat dorsal root ganglion (DRG) neurons, we have explored the ability of nerve growth factor (NGF) to acutely (within minutes) sensitize responses of nociceptors to capsaicin or noxious heat during postnatal development.	Capsaicin	182-191	nerve growth factor	Rattus norvegicus	111-114
15201308-2	2004	While robust sensitization of noxious heat or capsaicin responses by NGF is observed in adult DRG neurons, responses to such stimuli in trkA-positive neurons from early postnatal animals are not sensitized by NGF.	Capsaicin	46-55	nerve growth factor	Rattus norvegicus	69-72
15201344-7	2004	The inhibitory action of DHEA on the capsaicin-induced current may provide a basis for reducing capsaicin receptor-mediated nociception.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-114
15488290-3	2004	The antagonists FR173657 and capsazepine confirmed bradykinin B2 and vanilloid VR1 receptors mediated the responses to bradykinin and capsaicin, respectively.	Capsaicin	134-143	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-82
15464036-3	2004	The ensuing research established that the neuropharmacological properties of capsaicin are due to its activation of the transient receptor potential ion channel of the vanilloid type 1 (TRPV1).	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	186-191
15494187-0	2004	Beta adrenergic inhibition of capsaicin-induced, NK1 receptor-mediated nerve growth factor biosynthesis in rat skin.	Capsaicin	30-39	tachykinin receptor 1	Rattus norvegicus	49-61
15494187-0	2004	Beta adrenergic inhibition of capsaicin-induced, NK1 receptor-mediated nerve growth factor biosynthesis in rat skin.	Capsaicin	30-39	nerve growth factor	Rattus norvegicus	71-90
15494187-2	2004	Since NGF is a neurotrophic and immunomodulatory factor contributing to inflammatory hyperalgesia and tissue response to injury, this study was conducted in order to investigate the mechanisms by which afferent neuron stimulation by topical application of capsaicin increases NGF in the rat skin.	Capsaicin	256-265	nerve growth factor	Rattus norvegicus	6-9
15494187-2	2004	Since NGF is a neurotrophic and immunomodulatory factor contributing to inflammatory hyperalgesia and tissue response to injury, this study was conducted in order to investigate the mechanisms by which afferent neuron stimulation by topical application of capsaicin increases NGF in the rat skin.	Capsaicin	256-265	nerve growth factor	Rattus norvegicus	276-279
15494187-4	2004	Topical capsaicin (>1 mg/ml ethanol) caused a concentration- and time-dependent increase in the concentration of NGF in rat skin.	Capsaicin	8-17	nerve growth factor	Rattus norvegicus	116-119
15494187-5	2004	The capsaicin-induced increase of NGF was not significantly affected by indomethacin administered at a dose (2 mg/kg) that abolishes prostaglandin E2 biosynthesis.	Capsaicin	4-13	nerve growth factor	Rattus norvegicus	34-37
15494187-9	2004	The results show that topical administration of capsaicin causes a primarily NK1 receptor-dependent increase in the NGF content of rat skin, which is susceptible to inhibition by beta adrenergic agonists.	Capsaicin	48-57	tachykinin receptor 1	Rattus norvegicus	77-89
15494187-9	2004	The results show that topical administration of capsaicin causes a primarily NK1 receptor-dependent increase in the NGF content of rat skin, which is susceptible to inhibition by beta adrenergic agonists.	Capsaicin	48-57	nerve growth factor	Rattus norvegicus	116-119
15464274-1	2004	TRPV1, a receptor for capsaicin, plays a key role in mediating thermal and inflammatory pain.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
15464099-8	2004	Pretreatment with capsaicin (50 mg/kg, s.c.), which depletes transmitters in capsaicin-sensitive sensory nerves, also blocked the cardioprotection of preconditioning and reduced the synthesis and release of CGRP, but did not affect the concentration of NO.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	207-211
15464028-3	2004	The present review concentrates on the effects of capsaicin--through the transient receptor potential vanilloid receptor type 1 (TRPV1) receptor--on innervated gastrointestinal, respiratory and genitourinary smooth muscle preparations.	Capsaicin	50-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	129-134
15464028-4	2004	Tachykinins and calcitonin gene-related peptide (CGRP) are the most widely accepted transmitters to mediate "local efferent" effects of capsaicin-sensitive nerves in tissues taken from animals.	Capsaicin	136-145	calcitonin related polypeptide alpha	Homo sapiens	16-47
15464028-4	2004	Tachykinins and calcitonin gene-related peptide (CGRP) are the most widely accepted transmitters to mediate "local efferent" effects of capsaicin-sensitive nerves in tissues taken from animals.	Capsaicin	136-145	calcitonin related polypeptide alpha	Homo sapiens	49-53
15496307-1	2004	The purpose of this study was to investigate the role of the renin-angiotensin-aldosterone system in hypertension development and cardiovascular structural changes in a salt-sensitive hypertensive model induced by capsaicin (CAP).	Capsaicin	214-223	renin	Rattus norvegicus	61-66
15496307-1	2004	The purpose of this study was to investigate the role of the renin-angiotensin-aldosterone system in hypertension development and cardiovascular structural changes in a salt-sensitive hypertensive model induced by capsaicin (CAP).	Capsaicin	225-228	renin	Rattus norvegicus	61-66
15464036-4	2004	Expressed by primary afferent neurons innervating the gut and other organs, TRPV1 is gated not only by vanilloids such as capsaicin, but also by noxious heat, acidosis and intracellular lipid mediators such as anandamide and lipoxygenase products.	Capsaicin	122-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
15152028-1	2004	Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)].	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	86-114
15383218-0	2004	Capsaicin, a spicy component of hot pepper, induces apoptosis by activation of the peroxisome proliferator-activated receptor gamma in HT-29 human colon cancer cells.	Capsaicin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	83-131
15383218-4	2004	In the present study, we investigated the potential of capsaicin to induce apoptotic cell death in human colon cancer cells and the association of PPARgamma in the capsaicin action.	Capsaicin	164-173	peroxisome proliferator activated receptor gamma	Homo sapiens	147-156
15383218-10	2004	Capsaicin-induced cell death was completely blocked by bisphenol A diglycidyl ether, a specific PPARgamma antagonist.	Capsaicin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	96-105
15383218-12	2004	Our data suggest that capsaicin-induced apoptotic cell death in HT-29 human colon cancer cells could be associated with the PPARgamma pathway without the involvement of the vanilloid receptor.	Capsaicin	22-31	peroxisome proliferator activated receptor gamma	Homo sapiens	124-133
15754496-5	2004	In the capsaicin and capsinoid-I groups, fatty acid synthase (FAS) activities were lower and hepatic triacylglycerol lipase (HTGL) [EC 3.1.1.3] activities tended to be higher than those of control group.	Capsaicin	7-16	fatty acid synthase	Rattus norvegicus	41-60
15754496-5	2004	In the capsaicin and capsinoid-I groups, fatty acid synthase (FAS) activities were lower and hepatic triacylglycerol lipase (HTGL) [EC 3.1.1.3] activities tended to be higher than those of control group.	Capsaicin	7-16	fatty acid synthase	Rattus norvegicus	62-65
15754496-5	2004	In the capsaicin and capsinoid-I groups, fatty acid synthase (FAS) activities were lower and hepatic triacylglycerol lipase (HTGL) [EC 3.1.1.3] activities tended to be higher than those of control group.	Capsaicin	7-16	lipase C, hepatic type	Rattus norvegicus	93-123
15754496-5	2004	In the capsaicin and capsinoid-I groups, fatty acid synthase (FAS) activities were lower and hepatic triacylglycerol lipase (HTGL) [EC 3.1.1.3] activities tended to be higher than those of control group.	Capsaicin	7-16	lipase C, hepatic type	Rattus norvegicus	125-129
15152028-1	2004	Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)].	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-119
15754496-6	2004	Lipoprotein lipase (LPL) [EC 3.1.1.34] activity in adipose tissue was higher in the capsaicin and capsinoid-II groups than in the control group.	Capsaicin	84-93	lipoprotein lipase	Rattus norvegicus	0-18
15152028-1	2004	Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)].	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	135-180
15754496-6	2004	Lipoprotein lipase (LPL) [EC 3.1.1.34] activity in adipose tissue was higher in the capsaicin and capsinoid-II groups than in the control group.	Capsaicin	84-93	lipoprotein lipase	Rattus norvegicus	20-23
15152028-1	2004	Capsaicin produces thermal allodynia in animals and humans by acting as an agonist at vanilloid receptor subtype 1 [VR1; also known as transient receptor potential vanilloid type 1 (TRPV1)].	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	182-187
15363879-8	2004	PAF-induced tactile allodynia and thermal hyperalgesia disappeared in neonatally capsaicin-treated adult mice, while tactile allodynia but not thermal hyperalgesia induced by intrathecally injected alpha,beta-methylene ATP, a P2X receptor agonist, was capsaicin-insensitive.	Capsaicin	81-90	patchy fur	Mus musculus	0-3
15363879-8	2004	PAF-induced tactile allodynia and thermal hyperalgesia disappeared in neonatally capsaicin-treated adult mice, while tactile allodynia but not thermal hyperalgesia induced by intrathecally injected alpha,beta-methylene ATP, a P2X receptor agonist, was capsaicin-insensitive.	Capsaicin	252-261	patchy fur	Mus musculus	0-3
15363879-10	2004	PAF-evoked tactile allodynia is suggested to be mediated by ATP and the following NMDA and NO cascade through capsaicin-sensitive fiber, different from exogenously injected alpha,beta-methylene ATP which is insensitive to capsaicin treatment.	Capsaicin	110-119	patchy fur	Mus musculus	0-3
15363879-10	2004	PAF-evoked tactile allodynia is suggested to be mediated by ATP and the following NMDA and NO cascade through capsaicin-sensitive fiber, different from exogenously injected alpha,beta-methylene ATP which is insensitive to capsaicin treatment.	Capsaicin	222-231	patchy fur	Mus musculus	0-3
15475832-1	2004	BACKGROUND: Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release.	Capsaicin	12-21	calcitonin related polypeptide alpha	Homo sapiens	92-123
15313406-4	2004	Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.	Capsaicin	130-139	tumor necrosis factor	Homo sapiens	205-213
15313406-4	2004	Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.	Capsaicin	130-139	FosB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	242-246
15313406-4	2004	Our results provide evidence for a differential effect of chemopreventive agents such as beta-lapachone, emodin, sanguinarine and capsaicin, which significantly inhibit reporter gene expression as well as TNFalpha- and TPA-induced binding of AP-1 and NF-kappaB, whereas trans-anethole and silymarin do not produce any inhibitory effect.	Capsaicin	130-139	nuclear factor kappa B subunit 1	Homo sapiens	251-260
15312791-0	2004	Effect of protein kinase C blockade on phosphorylation of NR1 in dorsal horn and spinothalamic tract cells caused by intradermal capsaicin injection in rats.	Capsaicin	129-138	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	58-61
15312791-1	2004	We have previously reported that protein kinase A (PKA) is involved in the phosphorylation of NR1 subunits of N-methyl-d-aspartate (NMDA) receptors in dorsal horn neurons after intradermal injection of capsaicin (CAP).	Capsaicin	202-211	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	33-49
15312791-1	2004	We have previously reported that protein kinase A (PKA) is involved in the phosphorylation of NR1 subunits of N-methyl-d-aspartate (NMDA) receptors in dorsal horn neurons after intradermal injection of capsaicin (CAP).	Capsaicin	202-211	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	51-54
15312791-1	2004	We have previously reported that protein kinase A (PKA) is involved in the phosphorylation of NR1 subunits of N-methyl-d-aspartate (NMDA) receptors in dorsal horn neurons after intradermal injection of capsaicin (CAP).	Capsaicin	202-211	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	94-97
15312791-1	2004	We have previously reported that protein kinase A (PKA) is involved in the phosphorylation of NR1 subunits of N-methyl-d-aspartate (NMDA) receptors in dorsal horn neurons after intradermal injection of capsaicin (CAP).	Capsaicin	213-216	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	33-49
15312791-1	2004	We have previously reported that protein kinase A (PKA) is involved in the phosphorylation of NR1 subunits of N-methyl-d-aspartate (NMDA) receptors in dorsal horn neurons after intradermal injection of capsaicin (CAP).	Capsaicin	213-216	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	51-54
15312791-1	2004	We have previously reported that protein kinase A (PKA) is involved in the phosphorylation of NR1 subunits of N-methyl-d-aspartate (NMDA) receptors in dorsal horn neurons after intradermal injection of capsaicin (CAP).	Capsaicin	213-216	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	94-97
15385613-3	2004	Intradermal injection of capsaicin and NGF produce heat hyperalgesia by activating their respective TRPV1 (transient receptor potential vanilloid receptor-1) and TrkA receptors on nociceptor sensory nerve terminals.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	100-105
15385613-3	2004	Intradermal injection of capsaicin and NGF produce heat hyperalgesia by activating their respective TRPV1 (transient receptor potential vanilloid receptor-1) and TrkA receptors on nociceptor sensory nerve terminals.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	107-156
15385613-6	2004	Capsaicin and NGF induce phosphorylation of the PI3K downstream target AKT (protein kinase B), which is blocked by the PI3K inhibitors LY294002 and wortmannin, indicative of the activation of PI3K by both agents.	Capsaicin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	71-74
15385613-7	2004	ERK activation by capsaicin and NGF was also blocked by PI3K inhibitors.	Capsaicin	18-27	Eph receptor B1	Rattus norvegicus	0-3
15385613-8	2004	Similarly, intradermal capsaicin in rats activated PI3K and ERK in C-fiber DRG neurons and epidermal nerve fibers.	Capsaicin	23-32	Eph receptor B1	Rattus norvegicus	60-63
15385613-9	2004	Injection of PI3K or MEK (ERK kinase) inhibitors into the hindpaw attenuated capsaicin- and NGF-evoked heat hyperalgesia but did not change basal heat sensitivity.	Capsaicin	77-86	Eph receptor B1	Rattus norvegicus	26-29
15385613-11	2004	In acutely dissociated DRG neurons, the capsaicin-induced TRPV1 current was strikingly potentiated by NGF, and this potentiation was completely blocked by PI3K inhibitors and primarily suppressed by MEK inhibitors.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-63
15363396-7	2004	Determinants of icilin sensitivity map to a region of TRPM8 that corresponds to the capsaicin binding site on the noxious heat receptor TRPV1, suggesting a conserved molecular logic for gating of these thermosensitive channels by chemical agonists.	Capsaicin	84-93	transient receptor potential cation channel subfamily M member 8	Homo sapiens	54-59
15363396-7	2004	Determinants of icilin sensitivity map to a region of TRPM8 that corresponds to the capsaicin binding site on the noxious heat receptor TRPV1, suggesting a conserved molecular logic for gating of these thermosensitive channels by chemical agonists.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	136-141
15289293-2	2004	Two unsaturated members of this family of lipids, N-arachidonoyl-dopamine (NADA) and N-oleoyl-dopamine, were shown to potently activate the transient receptor potential channel type V1 (TRPV1), also known as the vanilloid receptor type 1 for capsaicin.	Capsaicin	242-251	transient receptor potential cation channel subfamily V member 1	Homo sapiens	186-191
15315527-1	2004	It is suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene related peptide (CGRP), resulting in cranial vasodilatation and central nociception.	Capsaicin	46-55	Calcitonin gene-related peptide	Sus scrofa	100-131
15315527-1	2004	It is suggested that during a migraine attack capsaicin-sensitive trigeminal sensory nerves release calcitonin gene related peptide (CGRP), resulting in cranial vasodilatation and central nociception.	Capsaicin	46-55	Calcitonin gene-related peptide	Sus scrofa	133-137
15347383-0	2004	Nerve growth factor-induced substance P in capsaicin-insensitive vagal neurons innervating the lower mouse airway.	Capsaicin	43-52	tachykinin 1	Mus musculus	28-39
15475832-1	2004	BACKGROUND: Capsaicin has been shown to exert direct vasodilating effects through increased calcitonin gene-related peptide (CGRP) release.	Capsaicin	12-21	calcitonin related polypeptide alpha	Homo sapiens	125-129
15351928-4	2004	The sensitizing effect of fenoterol was inhibited by high concentration of capsaicin (10 microM, 30 min before fenoterol sensitization), which induces depletion of mediators from sensory nerves, or co-incubation of fenoterol and capsazepine (1 microM), a vanilloid TRPV-1 receptor antagonist.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	265-271
15311112-6	2004	caused a depressor effect concomitantly with an increase in the plasma concentration of CGRP in a dose-dependent manner, which was blocked by capsaicin (used to deplete the CGRP from sensory nerves) or capsazepine (a competitive VR1 antagonist), causing an approximately 85% and approximately 80% change in mean arterial pressure, respectively, and by either of them, causing an approximately 90% elevation of plasma CGRP.	Capsaicin	142-151	calcitonin-related polypeptide alpha	Rattus norvegicus	173-177
15311112-9	2004	Treatment with Rut significantly increased the synthesis and release of CGRP, as shown by the increase in the levels of CGRP mRNA and peptide in the dorsal root ganglia, the density of CGRP immunoreactive nerve fibers in the mesenteric artery, the CGRP content in the spinal cord and the plasma concentration of CGRP, which was markedly attenuated by pretreatment with capsaicin.	Capsaicin	369-378	calcitonin-related polypeptide alpha	Rattus norvegicus	72-76
15305089-9	2004	In contrast to the control group, increased Fos expression was found following the use of both capsaicin and bradykinin in a variety of areas of the brain.	Capsaicin	95-104	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	44-47
15311112-6	2004	caused a depressor effect concomitantly with an increase in the plasma concentration of CGRP in a dose-dependent manner, which was blocked by capsaicin (used to deplete the CGRP from sensory nerves) or capsazepine (a competitive VR1 antagonist), causing an approximately 85% and approximately 80% change in mean arterial pressure, respectively, and by either of them, causing an approximately 90% elevation of plasma CGRP.	Capsaicin	142-151	calcitonin-related polypeptide alpha	Rattus norvegicus	88-92
15311112-6	2004	caused a depressor effect concomitantly with an increase in the plasma concentration of CGRP in a dose-dependent manner, which was blocked by capsaicin (used to deplete the CGRP from sensory nerves) or capsazepine (a competitive VR1 antagonist), causing an approximately 85% and approximately 80% change in mean arterial pressure, respectively, and by either of them, causing an approximately 90% elevation of plasma CGRP.	Capsaicin	142-151	calcitonin-related polypeptide alpha	Rattus norvegicus	173-177
15311112-6	2004	caused a depressor effect concomitantly with an increase in the plasma concentration of CGRP in a dose-dependent manner, which was blocked by capsaicin (used to deplete the CGRP from sensory nerves) or capsazepine (a competitive VR1 antagonist), causing an approximately 85% and approximately 80% change in mean arterial pressure, respectively, and by either of them, causing an approximately 90% elevation of plasma CGRP.	Capsaicin	142-151	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	229-232
15311065-1	2004	PURPOSE: Overactive bladder symptoms due to various etiologies have been successfully treated with capsaicin by desensitization of the temperature sensitive vanilloid receptor TRPV1.	Capsaicin	99-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	176-181
15351928-5	2004	Moreover, short pretreatment of bronchi with capsaicin (10 microM) or capsazepine (1 microM) after sensitization by fenoterol decreased the rise in smooth muscle contraction to endothelin-1.	Capsaicin	45-54	endothelin 1	Homo sapiens	177-189
15194687-6	2004	In addition, low levels of 2APB strongly potentiate the effect of capsaicin, protons, and heat on TRPV1 as well as that of heat on TRPV3 expressed in Xenopus oocytes.	Capsaicin	66-75	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	98-103
15358238-1	2004	Capsaicin-sensitive afferent neurons including transient receptor potential vanilloid subfamily 1, TRPV1, and neurohormonal peptides participate in the physiological regulation of pancreatic endocrine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
15288426-3	2004	Extracellular-calcium dependent CGRP release was stimulated by both capsaicin and neuronal depolarization with KCl.	Capsaicin	68-77	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
15288426-4	2004	The capsaicin (1 microM)-evoked CGRP release was blocked by capsazepine and was also attenuated in the presence of the cyclooxygenase inhibitor, indomethacin, an effect that was reversed when slices were stimulated with capsaicin in the presence of the cyclooxygenase metabolite, prostaglandin E(2).	Capsaicin	4-13	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
15288426-4	2004	The capsaicin (1 microM)-evoked CGRP release was blocked by capsazepine and was also attenuated in the presence of the cyclooxygenase inhibitor, indomethacin, an effect that was reversed when slices were stimulated with capsaicin in the presence of the cyclooxygenase metabolite, prostaglandin E(2).	Capsaicin	220-229	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
15304360-7	2004	Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma.	Capsaicin	89-98	peroxisome proliferator activated receptor gamma	Mus musculus	24-33
15304360-7	2004	Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma.	Capsaicin	89-98	tumor necrosis factor	Mus musculus	114-122
15304360-7	2004	Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma.	Capsaicin	89-98	peroxisome proliferator activated receptor gamma	Mus musculus	203-212
15304360-7	2004	Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma.	Capsaicin	170-179	peroxisome proliferator activated receptor gamma	Mus musculus	24-33
15177919-5	2004	Ghrelin-induced protection was abolished by vagotomy and attenuated by suppression of COX, deactivation of afferent nerves with neurotoxic dose of capsaicin or CGRP(8-37) and by inhibition of NOS with L-NNA but not influenced by medullectomy and administration of 6-hydroxydopamine.	Capsaicin	147-156	ghrelin and obestatin prepropeptide	Rattus norvegicus	0-7
15304360-0	2004	Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.	Capsaicin	0-9	tumor necrosis factor	Mus musculus	37-64
15304360-0	2004	Capsaicin inhibits the production of tumor necrosis factor alpha by LPS-stimulated murine macrophages, RAW 264.7: a PPARgamma ligand-like action as a novel mechanism.	Capsaicin	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	116-125
15304360-3	2004	In order to further clarify the mechanism underlying the anti-inflammatory action of capsaicin, we investigated whether capsaicin alters PPARgamma activity, which regulates the production of the pro-inflammatory cytokine TNFalpha.	Capsaicin	120-129	peroxisome proliferator activated receptor gamma	Mus musculus	137-146
15304360-3	2004	In order to further clarify the mechanism underlying the anti-inflammatory action of capsaicin, we investigated whether capsaicin alters PPARgamma activity, which regulates the production of the pro-inflammatory cytokine TNFalpha.	Capsaicin	120-129	tumor necrosis factor	Mus musculus	221-229
15304360-4	2004	Capsaicin significantly inhibited the production of TNFalpha by macrophages in a dose-dependent manner.	Capsaicin	0-9	tumor necrosis factor	Mus musculus	52-60
15304360-5	2004	Simultaneous exposure of the cells to capsaicin and PPARgamma agonist troglitazone or RXR agonist LG100268 resulted in stronger inhibition of TNFalpha production compared to the cells treated with either capsaicin, troglitazone, or LG100268 alone.	Capsaicin	38-47	tumor necrosis factor	Mus musculus	142-150
15304360-7	2004	Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma.	Capsaicin	170-179	tumor necrosis factor	Mus musculus	114-122
15304360-7	2004	Furthermore, a specific PPARgamma antagonist T0070907 abrogated the inhibitory action of capsaicin on LPS-induced TNFalpha production by RAW 264.7 cells, indicating that capsaicin acts like a ligand for PPARgamma.	Capsaicin	170-179	peroxisome proliferator activated receptor gamma	Mus musculus	203-212
15304360-8	2004	Our data demonstrate for the first time that the anti-inflammatory action of capsaicin may be mediated by PPARgamma activation in LPS-stimulated RAW 264.7 cells.	Capsaicin	77-86	peroxisome proliferator activated receptor gamma	Mus musculus	106-115
15358238-4	2004	Capsaicin (10(-11)-10(-9) M) dose-dependently increased insulin secretion from RIN cells, and this effect was inhibited by either a TRPV1 inhibitor capsazepine or EDTA.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	132-137
15304360-6	2004	Luciferase reporter assay revealed that capsaicin induced GAL4/PPARgamma chimera and full length PPARgamma (PPRE) transactivations in a dose-dependent manner.	Capsaicin	40-49	lectin, galactose binding, soluble 4	Mus musculus	58-62
15304360-6	2004	Luciferase reporter assay revealed that capsaicin induced GAL4/PPARgamma chimera and full length PPARgamma (PPRE) transactivations in a dose-dependent manner.	Capsaicin	40-49	peroxisome proliferator activated receptor gamma	Mus musculus	63-72
15084474-3	2004	Capsaicin-induced currents in identified colonic dorsal root ganglion neurons were blocked by the c-Src kinase inhibitor PP2 and enhanced by the tyrosine phosphatase inhibitor sodium orthovandate.	Capsaicin	0-9	C-terminal Src kinase	Rattus norvegicus	98-110
15304360-6	2004	Luciferase reporter assay revealed that capsaicin induced GAL4/PPARgamma chimera and full length PPARgamma (PPRE) transactivations in a dose-dependent manner.	Capsaicin	40-49	peroxisome proliferator activated receptor gamma	Mus musculus	97-106
15306801-5	2004	The chemical agonists menthol (TRPM8) and capsaicin (TRPV1) function as gating modifiers, shifting activation curves towards physiological membrane potentials.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-58
15276244-4	2004	We examined whether a blocking antibody to the p75 neurotrophin receptor can prevent the NGF-induced enhancement of excitability in capsaicin-sensitive small-diameter sensory neurons that have been isolated from the adult rat.	Capsaicin	132-141	nerve growth factor receptor	Rattus norvegicus	47-50
15117731-5	2004	The response to exogenous apo A-IV injections was significantly reduced by 77 and 55%, respectively, in rats treated with the CCK(1) receptor blocker devazepide or after functional vagal deafferentation by perineural capsaicin treatment.	Capsaicin	217-226	apolipoprotein A4	Rattus norvegicus	26-34
15084474-3	2004	Capsaicin-induced currents in identified colonic dorsal root ganglion neurons were blocked by the c-Src kinase inhibitor PP2 and enhanced by the tyrosine phosphatase inhibitor sodium orthovandate.	Capsaicin	0-9	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	121-124
15084474-4	2004	PP2 also abolished currents in human embryonic kidney-293 cells transfected with rat TRPV1, whereas cotransfection of TRPV1 with v-Src resulted in fivefold increase in capsaicin-induced currents.	Capsaicin	168-177	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	118-123
15084474-5	2004	In cells transfected with dominant-negative c-Src and TRPV1, capsaicin-induced currents were decreased by approximately fourfold.	Capsaicin	61-70	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	44-49
15084474-5	2004	In cells transfected with dominant-negative c-Src and TRPV1, capsaicin-induced currents were decreased by approximately fourfold.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
15460446-7	2004	Pretreatment of H-ras MCF10A cells with an antioxidant N-acetylcysteine (NAC) significantly reversed capsaicin-induced growth inhibition, suggesting that ROS may mediate the apoptosis of H-ras-transformed cells induced by capsaicin.	Capsaicin	222-231	HRas proto-oncogene, GTPase	Homo sapiens	16-21
15460446-7	2004	Pretreatment of H-ras MCF10A cells with an antioxidant N-acetylcysteine (NAC) significantly reversed capsaicin-induced growth inhibition, suggesting that ROS may mediate the apoptosis of H-ras-transformed cells induced by capsaicin.	Capsaicin	222-231	HRas proto-oncogene, GTPase	Homo sapiens	187-192
15460446-0	2004	Capsaicin-induced apoptosis of H-ras-transformed human breast epithelial cells is Rac-dependent via ROS generation.	Capsaicin	0-9	HRas proto-oncogene, GTPase	Homo sapiens	31-36
15460446-9	2004	Based on the studies using a wild type Rac1 and a dominant negative Rac1 constructs, we propose that Rac1 activity is critical for inhibitory effect of capsaicin on growth of H-ras-transformed MCF10A cells possibly through ROS generation.	Capsaicin	152-161	Rac family small GTPase 1	Homo sapiens	39-43
15460446-0	2004	Capsaicin-induced apoptosis of H-ras-transformed human breast epithelial cells is Rac-dependent via ROS generation.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	82-85
15460446-2	2004	We have previously shown that capsaicin selectively induces apoptosis in H-ras-transformed MCF10A human breast epithelial cells but not in their normal cell counterparts (Int.	Capsaicin	30-39	HRas proto-oncogene, GTPase	Homo sapiens	73-78
15460446-9	2004	Based on the studies using a wild type Rac1 and a dominant negative Rac1 constructs, we propose that Rac1 activity is critical for inhibitory effect of capsaicin on growth of H-ras-transformed MCF10A cells possibly through ROS generation.	Capsaicin	152-161	Rac family small GTPase 1	Homo sapiens	68-72
15460446-5	2004	In this study, we investigated the possible roles of reactive oxygen species (ROS) and Rac1 in capsaicin-induced apoptosis of H-ras MCF10A cells.	Capsaicin	95-104	Rac family small GTPase 1	Homo sapiens	87-91
15460446-5	2004	In this study, we investigated the possible roles of reactive oxygen species (ROS) and Rac1 in capsaicin-induced apoptosis of H-ras MCF10A cells.	Capsaicin	95-104	HRas proto-oncogene, GTPase	Homo sapiens	126-131
15460446-6	2004	Selective induction of ROS generation by capsaicin treatment was observed only in H-ras MCF10A cells.	Capsaicin	41-50	HRas proto-oncogene, GTPase	Homo sapiens	82-87
15460446-7	2004	Pretreatment of H-ras MCF10A cells with an antioxidant N-acetylcysteine (NAC) significantly reversed capsaicin-induced growth inhibition, suggesting that ROS may mediate the apoptosis of H-ras-transformed cells induced by capsaicin.	Capsaicin	101-110	HRas proto-oncogene, GTPase	Homo sapiens	16-21
15460446-7	2004	Pretreatment of H-ras MCF10A cells with an antioxidant N-acetylcysteine (NAC) significantly reversed capsaicin-induced growth inhibition, suggesting that ROS may mediate the apoptosis of H-ras-transformed cells induced by capsaicin.	Capsaicin	101-110	HRas proto-oncogene, GTPase	Homo sapiens	187-192
15460446-9	2004	Based on the studies using a wild type Rac1 and a dominant negative Rac1 constructs, we propose that Rac1 activity is critical for inhibitory effect of capsaicin on growth of H-ras-transformed MCF10A cells possibly through ROS generation.	Capsaicin	152-161	Rac family small GTPase 1	Homo sapiens	68-72
15460446-9	2004	Based on the studies using a wild type Rac1 and a dominant negative Rac1 constructs, we propose that Rac1 activity is critical for inhibitory effect of capsaicin on growth of H-ras-transformed MCF10A cells possibly through ROS generation.	Capsaicin	152-161	HRas proto-oncogene, GTPase	Homo sapiens	175-180
15335215-15	2004	High-dose capsaicin treatment, which depletes SP in nerve endings, caused 42% loss of SP in skin independent of amount of tissue extracted Our results suggest that a second acid extraction of tissue should be performed and that column extraction is clearly detrimental with skin samples.	Capsaicin	10-19	tachykinin precursor 1	Homo sapiens	46-48
15335215-15	2004	High-dose capsaicin treatment, which depletes SP in nerve endings, caused 42% loss of SP in skin independent of amount of tissue extracted Our results suggest that a second acid extraction of tissue should be performed and that column extraction is clearly detrimental with skin samples.	Capsaicin	10-19	tachykinin precursor 1	Homo sapiens	86-88
15288402-5	2004	In vivo behavioral studies demonstrate that intraplantar injection of 20.0 but not 2.0 microM octreotide (OCT, SSTR agonist) significantly reduces capsaicin (CAP, a ligand for TRPV1) -induced flinching and lifting/licking behaviors.	Capsaicin	147-156	transient receptor potential cation channel subfamily V member 1	Homo sapiens	176-181
15277316-0	2004	The cannabinomimetic arachidonyl-2-chloroethylamide (ACEA) acts on capsaicin-sensitive TRPV1 receptors but not cannabinoid receptors in rat joints.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-92
15277316-10	2004	Rather than a classic CB receptor pathway, ACEA exerts its vasomotor influence by acting via TRPV(1) receptors located on the terminal branches of capsaicin-sensitive afferent nerves innervating the joint.	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	93-100
15265675-0	2004	Involvement of substance P, CGRP and histamine in the hyperalgesia and cytokine upregulation induced by intraplantar injection of capsaicin in rats.	Capsaicin	130-139	calcitonin-related polypeptide alpha	Rattus norvegicus	28-32
15203132-3	2004	Pharmacological studies using electrophysiological and FLIPR Ca(2+) based assays showed compound 5 was an antagonist versus capsaicin, noxious heat and acid mediated activation of TRPV1.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	180-185
15232294-2	2004	Either the PAR-2 agonist SLIGRL-NH2 or capsaicin, injected into the parotid duct, caused expression of Fos in the trigeminal subnucleus caudalis, although the PAR-2-inactive reversed peptide had no such effect.	Capsaicin	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-106
15232294-3	2004	The Fos expression caused by PAR-2 activation was inhibited by ablation of capsaicin-sensitive sensory neurons.	Capsaicin	75-84	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-7
15232294-3	2004	The Fos expression caused by PAR-2 activation was inhibited by ablation of capsaicin-sensitive sensory neurons.	Capsaicin	75-84	F2R like trypsin receptor 1	Rattus norvegicus	29-34
15232294-5	2004	Our data thus reveal that activation of PAR-2 in the parotid gland can cause activation of trigeminal nociceptive neurons via capsaicin-sensitive sensory nerves most probably by a non-inflammatory mechanism.	Capsaicin	126-135	F2R like trypsin receptor 1	Rattus norvegicus	40-45
15126053-8	2004	The effect of capsaicin on [Ca(2+)](i) was greater in migrating HGF/SF-treated cells, and this was inhibited by capsazepine.	Capsaicin	14-23	hepatocyte growth factor	Homo sapiens	64-70
15120476-7	2004	Both CGRP (1 x 10(-7) to 1 x 10(-5) M) and capsaicin (1 x 10-(8) to 1 x 10(-6)M) significantly inhibited basal TGFalpha release in a dose-dependent fashion that ranged from -20% to -39%.	Capsaicin	43-52	transforming growth factor alpha	Rattus norvegicus	111-119
15120476-8	2004	In contrast, capsaicin-induced sensory denervation caused significant increases in both basal TGFalpha release and TGFalpha tissue content.	Capsaicin	13-22	transforming growth factor alpha	Rattus norvegicus	94-102
15120476-8	2004	In contrast, capsaicin-induced sensory denervation caused significant increases in both basal TGFalpha release and TGFalpha tissue content.	Capsaicin	13-22	transforming growth factor alpha	Rattus norvegicus	115-123
15120476-9	2004	CONCLUSION: Function interactions between TGFalpha and gastric sensory neurons are suggested by the observations that (1) TGFalpha stimulated CGRP release from gastric sensory neurons; (2) CGRP and acute capsaicin treatment inhibited TGFalpha release and; (3) capsaicin-induced sensory denervation caused significant increases in both gastric TGFalpha basal release and tissue content.	Capsaicin	204-213	transforming growth factor alpha	Rattus norvegicus	42-50
15120476-9	2004	CONCLUSION: Function interactions between TGFalpha and gastric sensory neurons are suggested by the observations that (1) TGFalpha stimulated CGRP release from gastric sensory neurons; (2) CGRP and acute capsaicin treatment inhibited TGFalpha release and; (3) capsaicin-induced sensory denervation caused significant increases in both gastric TGFalpha basal release and tissue content.	Capsaicin	260-269	transforming growth factor alpha	Rattus norvegicus	42-50
15120476-9	2004	CONCLUSION: Function interactions between TGFalpha and gastric sensory neurons are suggested by the observations that (1) TGFalpha stimulated CGRP release from gastric sensory neurons; (2) CGRP and acute capsaicin treatment inhibited TGFalpha release and; (3) capsaicin-induced sensory denervation caused significant increases in both gastric TGFalpha basal release and tissue content.	Capsaicin	260-269	transforming growth factor alpha	Rattus norvegicus	122-130
15120476-9	2004	CONCLUSION: Function interactions between TGFalpha and gastric sensory neurons are suggested by the observations that (1) TGFalpha stimulated CGRP release from gastric sensory neurons; (2) CGRP and acute capsaicin treatment inhibited TGFalpha release and; (3) capsaicin-induced sensory denervation caused significant increases in both gastric TGFalpha basal release and tissue content.	Capsaicin	260-269	calcitonin-related polypeptide alpha	Rattus norvegicus	189-193
15120476-9	2004	CONCLUSION: Function interactions between TGFalpha and gastric sensory neurons are suggested by the observations that (1) TGFalpha stimulated CGRP release from gastric sensory neurons; (2) CGRP and acute capsaicin treatment inhibited TGFalpha release and; (3) capsaicin-induced sensory denervation caused significant increases in both gastric TGFalpha basal release and tissue content.	Capsaicin	260-269	transforming growth factor alpha	Rattus norvegicus	122-130
15120476-9	2004	CONCLUSION: Function interactions between TGFalpha and gastric sensory neurons are suggested by the observations that (1) TGFalpha stimulated CGRP release from gastric sensory neurons; (2) CGRP and acute capsaicin treatment inhibited TGFalpha release and; (3) capsaicin-induced sensory denervation caused significant increases in both gastric TGFalpha basal release and tissue content.	Capsaicin	260-269	transforming growth factor alpha	Rattus norvegicus	122-130
15212441-0	2004	Role of calcitonin gene-related peptide in the sensitization of dorsal horn neurons to mechanical stimulation after intradermal injection of capsaicin.	Capsaicin	141-150	calcitonin-related polypeptide alpha	Rattus norvegicus	8-39
15212441-1	2004	This study was designed to assess the role of calcitonin gene-related peptide (CGRP) and its receptor in the sensitization of dorsal horn neurons induced by intradermal injection of capsaicin in rats.	Capsaicin	182-191	calcitonin-related polypeptide alpha	Rattus norvegicus	46-77
15212441-1	2004	This study was designed to assess the role of calcitonin gene-related peptide (CGRP) and its receptor in the sensitization of dorsal horn neurons induced by intradermal injection of capsaicin in rats.	Capsaicin	182-191	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
15212441-6	2004	Superfusion of CGRP(8-37) into the spinal cord at 45 min after capsaicin injection significantly reversed the increased background activity and responses to brush, press, and pinch applied to the receptive field.	Capsaicin	63-72	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
15212441-7	2004	On the other hand, spinal superfusion of CGRP(8-37) prior to capsaicin injection prevented the increased background activity and responses to brush, press, and pinch of WDR neurons that occurred following capsaicin injection in control experiments.	Capsaicin	61-70	calcitonin-related polypeptide alpha	Rattus norvegicus	41-45
15212441-7	2004	On the other hand, spinal superfusion of CGRP(8-37) prior to capsaicin injection prevented the increased background activity and responses to brush, press, and pinch of WDR neurons that occurred following capsaicin injection in control experiments.	Capsaicin	205-214	calcitonin-related polypeptide alpha	Rattus norvegicus	41-45
15212441-10	2004	Collectively, these results suggest that CGRP and its receptors are involved in the spinal cord central sensitization induced by intradermal injection of capsaicin.	Capsaicin	154-163	calcitonin-related polypeptide alpha	Rattus norvegicus	41-45
15608360-14	2004	Pancreatic secretory responses to leptin were totally abolished by prior capsaicin deactivation of sensory nerves or by pretreatment of the rats with tarazepide.	Capsaicin	73-82	leptin	Rattus norvegicus	34-40
15608360-18	2004	to the rats with intact or capsaicin-deactivated sensory nerves resulted in dose-dependent rise of plasma CCK level, reaching the highest value at the dose of 10.0 microg/kg i.d.	Capsaicin	27-36	cholecystokinin	Rattus norvegicus	106-109
14684379-5	2004	The c-fos expression in all these brain nuclei was blocked by truncal vagotomy as well as by perivagal capsaicin treatment, suggesting that vagal afferent pathways may mediate this response.	Capsaicin	103-112	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	4-9
15220790-3	2004	METHODS: The authors assessed spontaneous pain behavior and mechanical hypersensitivity induced by administration of capsaicin in the colon or paw of alpha(2A)-adrenoceptor knockout mice versus their wild-type controls.	Capsaicin	117-126	adrenergic receptor, alpha 2a	Mus musculus	150-172
15220790-4	2004	RESULTS: Enhanced pain hypersensitivity was observed in alpha(2A)-adrenoceptor knockout mice 20 min or more after administration of capsaicin, but before, hypersensitivity and spontaneous pain were of equal magnitude in alpha(2A)-adrenoceptor knockout and wild-type mice.	Capsaicin	132-141	adrenergic receptor, alpha 2a	Mus musculus	56-78
15220790-4	2004	RESULTS: Enhanced pain hypersensitivity was observed in alpha(2A)-adrenoceptor knockout mice 20 min or more after administration of capsaicin, but before, hypersensitivity and spontaneous pain were of equal magnitude in alpha(2A)-adrenoceptor knockout and wild-type mice.	Capsaicin	132-141	adrenergic receptor, alpha 2a	Mus musculus	220-242
15226163-6	2004	Cyclooxygenase-2 inhibitors become patients" preferred choice only if they are described as being 3 times as effective as capsaicin and are covered by insurance.	Capsaicin	122-131	prostaglandin-endoperoxide synthase 2	Homo sapiens	0-16
15275747-1	2004	We investigated the peripheral function of galanin (GAL) in capsaicin (CAP)-induced inflammatory pain.	Capsaicin	60-69	galanin and GMAP prepropeptide	Homo sapiens	43-50
15275747-1	2004	We investigated the peripheral function of galanin (GAL) in capsaicin (CAP)-induced inflammatory pain.	Capsaicin	60-69	galanin and GMAP prepropeptide	Homo sapiens	52-55
15275747-1	2004	We investigated the peripheral function of galanin (GAL) in capsaicin (CAP)-induced inflammatory pain.	Capsaicin	71-74	galanin and GMAP prepropeptide	Homo sapiens	43-50
15275747-8	2004	Also, 44.5% GalR2-positive DRG neurons label for the capsaicin receptor (vanilloid receptor 1, VR1) while 61.7% of VR1-positive DRG neurons label for GalR2; 28.1% of total DRG neurons are double-labeled supporting the hypothesis that GAL-induced effects are mediated by GalR2 on capsaicin-sensitive primary afferents.	Capsaicin	53-62	galanin receptor 2	Homo sapiens	12-17
15275770-3	2004	We investigated the temperature dependency of capsaicin-induced CGRP release from nociceptive nerve fibers in isolated rat skin over a range of ambient temperatures using different agonist concentrations (10(-7)-10(-5)M) and KCl (60 mM) for control.	Capsaicin	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
15275770-9	2004	Significant capsaicin responses even at 8 degrees C suggest a contribution of noxious-cold sensitive neurons known to coexpress CGRP and the capsaicin receptor.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	128-132
15275770-9	2004	Significant capsaicin responses even at 8 degrees C suggest a contribution of noxious-cold sensitive neurons known to coexpress CGRP and the capsaicin receptor.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	141-159
15182951-1	2004	The effect of systemic nerve growth factor (NGF) on neuropeptide content and capsaicin-evoked release of neuropeptide from in vitro spinal cord dorsal horn slices was examined.	Capsaicin	77-86	pyroglutamylated RFamide peptide	Rattus norvegicus	105-117
15182951-3	2004	Lumbar dorsal horn slices of the rat spinal cord from all groups showed a significant increase in immunoreactive calcitonin gene-related peptide (CGRP) release upon exposure to capsaicin.	Capsaicin	177-186	calcitonin-related polypeptide alpha	Rattus norvegicus	113-144
15182951-3	2004	Lumbar dorsal horn slices of the rat spinal cord from all groups showed a significant increase in immunoreactive calcitonin gene-related peptide (CGRP) release upon exposure to capsaicin.	Capsaicin	177-186	calcitonin-related polypeptide alpha	Rattus norvegicus	146-150
15196685-1	2004	In the present study, c-fos expression in the spinal cord has been used as a marker of neuronal activation induced by capsaicin-sensitive sensory afferents from the dorsal neck muscles in cats (n = 6).	Capsaicin	118-127	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	22-27
15196685-3	2004	In contrast to the control group (n = 3), 2 h after intramuscular capsaicin injection, c-fos expression was more extensive ipsilaterally to the injected side in the C3-C6 segments, and bilaterally in the L4-L6 segments.	Capsaicin	66-75	Fos proto-oncogene, AP-1 transcription factor subunit	Felis catus	87-92
15189776-2	2004	Greater relaxant responses in females were also induced by the vanilloid TRPV1 receptor agonist capsaicin (0.01 to 10 microM), whereas no sex differences were observed for the relaxations caused by either acetylcholine or sodium nitroprusside.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	73-78
15093708-5	2004	Bradykinin (BK(2)) receptor blockade inhibited degranulation of submucosal mast cells in the stomach and attenuated gastric vasodilation both in response to acid back diffusion and after stimulation of sensory neurons with capsaicin.	Capsaicin	223-232	bradykinin receptor B2	Rattus norvegicus	12-27
15155835-6	2004	Single-channel kinetic analysis shows that capsaicin potentiates CFTR by increasing the opening rate and decreasing the closing rate of the channel.	Capsaicin	43-52	cystic fibrosis transmembrane conductance regulator	Mus musculus	65-69
15175387-2	2004	Five of them can alternatively be activated by nonthermal stimuli such as capsaicin [transient receptor potential vanilloid 1 (TRPV1)] or hypo-osmolarity (TRPV2 and TRPV4).	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-125
15175387-2	2004	Five of them can alternatively be activated by nonthermal stimuli such as capsaicin [transient receptor potential vanilloid 1 (TRPV1)] or hypo-osmolarity (TRPV2 and TRPV4).	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 1	Homo sapiens	127-132
15148262-10	2004	6 Noladin ether evoked a concentration-dependent increase in intracellular Ca2+ concentration in TRPV1-HEK293 cells at 10 microm (36.5+/-3.2% of maximal capsaicin-induced response), but it was a less potent agonist than both capsaicin and anandamide and at 1 microm it was essentially inactive.	Capsaicin	153-162	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-102
15148262-10	2004	6 Noladin ether evoked a concentration-dependent increase in intracellular Ca2+ concentration in TRPV1-HEK293 cells at 10 microm (36.5+/-3.2% of maximal capsaicin-induced response), but it was a less potent agonist than both capsaicin and anandamide and at 1 microm it was essentially inactive.	Capsaicin	225-234	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-102
15155835-0	2004	Capsaicin potentiates wild-type and mutant cystic fibrosis transmembrane conductance regulator chloride-channel currents.	Capsaicin	0-9	cystic fibrosis transmembrane conductance regulator	Mus musculus	43-94
15155835-3	2004	In whole-cell experiments, capsaicin potentiates cAMP-stimulated wild-type CFTR currents expressed in NIH 3T3 cells or Chinese hamster ovary cells in a dose-dependent manner with a maximal response approximately 60% of that with genistein and an apparent Kd of 48.4 +/- 6.8 microM.	Capsaicin	27-36	cystic fibrosis transmembrane conductance regulator	Mus musculus	75-79
15155835-7	2004	Capsaicin may act as a partial agonist of genistein because the maximally enhanced wild-type CFTR currents with genistein are partially inhibited by capsaicin.	Capsaicin	0-9	cystic fibrosis transmembrane conductance regulator	Mus musculus	93-97
15155835-7	2004	Capsaicin may act as a partial agonist of genistein because the maximally enhanced wild-type CFTR currents with genistein are partially inhibited by capsaicin.	Capsaicin	149-158	cystic fibrosis transmembrane conductance regulator	Mus musculus	93-97
15155835-8	2004	Capsaicin increases DeltaR-CFTR, a protein kinase A (PKA)-independent, constitutively active channel, in cell-attached patches.	Capsaicin	0-9	cystic fibrosis transmembrane conductance regulator	Mus musculus	27-31
15155835-9	2004	In excised inside-out patches, capsaicin potentiates the PKA-phosphorylated, ATP-dependent CFTR activity.	Capsaicin	31-40	cystic fibrosis transmembrane conductance regulator	Mus musculus	91-95
15155835-10	2004	Both capsaicin and genistein potentiate the cAMP-stimulated G551D-CFTR, DeltaF508-CFTR, and 8SA mutant channel currents.	Capsaicin	5-14	cystic fibrosis transmembrane conductance regulator	Mus musculus	66-70
15155835-10	2004	Both capsaicin and genistein potentiate the cAMP-stimulated G551D-CFTR, DeltaF508-CFTR, and 8SA mutant channel currents.	Capsaicin	5-14	cystic fibrosis transmembrane conductance regulator	Mus musculus	82-86
15155835-11	2004	The binding site for capsaicin is probably located at the cytoplasmic domain of CFTR, because pipette application of capsaicin fails to potentiate CFTR activity.	Capsaicin	21-30	cystic fibrosis transmembrane conductance regulator	Mus musculus	80-84
15155835-11	2004	The binding site for capsaicin is probably located at the cytoplasmic domain of CFTR, because pipette application of capsaicin fails to potentiate CFTR activity.	Capsaicin	21-30	cystic fibrosis transmembrane conductance regulator	Mus musculus	147-151
15155835-11	2004	The binding site for capsaicin is probably located at the cytoplasmic domain of CFTR, because pipette application of capsaicin fails to potentiate CFTR activity.	Capsaicin	117-126	cystic fibrosis transmembrane conductance regulator	Mus musculus	80-84
15155835-12	2004	In conclusion, capsaicin is a partial agonist of genistein in activation of the CFTR chloride channel.	Capsaicin	15-24	cystic fibrosis transmembrane conductance regulator	Mus musculus	80-84
15157689-1	2004	Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin receptor (TRPV1) expressed in non-neuronal host cells, and natively, in cultured dorsal root ganglion cells.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	166-184
15120595-5	2004	We also show that while the degree of Fos staining in the NTS of allergic mice was only diminished by neonatal capsaicin, it was completely blocked in the PVN.	Capsaicin	111-120	FBJ osteosarcoma oncogene	Mus musculus	38-41
15120568-2	2004	In this study, we have measured the effects of various neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and -4) on recombinant rat VR1-mediated intracellular calcium rise in response to capsaicin in VR1/C6 cells.	Capsaicin	224-233	brain-derived neurotrophic factor	Rattus norvegicus	91-124
15120568-2	2004	In this study, we have measured the effects of various neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and -4) on recombinant rat VR1-mediated intracellular calcium rise in response to capsaicin in VR1/C6 cells.	Capsaicin	224-233	neurotrophin 3	Rattus norvegicus	126-148
15120568-2	2004	In this study, we have measured the effects of various neurotrophins (nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and -4) on recombinant rat VR1-mediated intracellular calcium rise in response to capsaicin in VR1/C6 cells.	Capsaicin	224-233	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	169-172
15120568-3	2004	Our results clearly show that all neurotrophins sensitize the VR1 to capsaicin.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-65
15157689-1	2004	Capsaicin antagonists including ruthenium red, capsazepine and iodo-resiniferatoxin (I-RTX) have recently been shown to inhibit the activation by noxious heat of the capsaicin receptor (TRPV1) expressed in non-neuronal host cells, and natively, in cultured dorsal root ganglion cells.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	186-191
15128843-2	2004	Transient receptor potential vanilloid subfamily 1 (TRPV1) is a sensory neuron-specific cation channel that responds to capsaicin, protons, or heat stimulus.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-50
14996838-1	2004	Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine, and products of lipoxygenase).	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
14996838-1	2004	Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine, and products of lipoxygenase).	Capsaicin	126-135	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
14996838-1	2004	Vanilloid receptor 1 (TRPV1), a membrane-associated cation channel, is activated by the pungent vanilloid from chili peppers, capsaicin, and the ultra potent vanilloid from Euphorbia resinifera, resiniferatoxin (RTX), as well as by physical stimuli (heat and protons) and proposed endogenous ligands (anandamide, N-arachidonyldopamine, N-oleoyldopamine, and products of lipoxygenase).	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
14996838-2	2004	Only limited information is available in TRPV1 on the residues that contribute to vanilloid activation.	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
14996838-6	2004	Here we identify key residues (Met(547) and Thr(550)) in transmembrane regions 3 and 4 (TM3/4) of rat and human TRPV1 that confer vanilloid sensitivity, [(3)H]RTX binding and competitive antagonist binding to rabbit TRPV1.	Capsaicin	130-139	tropomyosin 4	Rattus norvegicus	88-93
14996838-6	2004	Here we identify key residues (Met(547) and Thr(550)) in transmembrane regions 3 and 4 (TM3/4) of rat and human TRPV1 that confer vanilloid sensitivity, [(3)H]RTX binding and competitive antagonist binding to rabbit TRPV1.	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
14996838-9	2004	Based on our data we propose a model of the TM3/4 region of TRPV1 bound to capsaicin or RTX that may aid in the development of potent TRPV1 antagonists with utility in the treatment of sensory disorders.	Capsaicin	75-84	tropomyosin 4	Rattus norvegicus	44-49
14996838-9	2004	Based on our data we propose a model of the TM3/4 region of TRPV1 bound to capsaicin or RTX that may aid in the development of potent TRPV1 antagonists with utility in the treatment of sensory disorders.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-65
14996838-9	2004	Based on our data we propose a model of the TM3/4 region of TRPV1 bound to capsaicin or RTX that may aid in the development of potent TRPV1 antagonists with utility in the treatment of sensory disorders.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	134-139
15135917-2	2004	The EC(50) of capsaicin and OLDA on (45)Ca accumulation of rTRPV1-expressing HT5-1 cells was 36 nM and 1.8 microM, respectively.	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-65
15135917-5	2004	Repeated application of OLDA and capsaicin caused similar desensitization in the Ca(2+) transients both in cultured neurons and rTRPV1-transfected HT5-1 cells.	Capsaicin	33-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	128-134
15135917-9	2004	It is concluded that on TRPV1 capsaicin receptors OLDA is 50 times less potent than capsaicin and it might serve as an endogenous ligand for TRPV1 in the rat, but more likely in humans.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
15135917-9	2004	It is concluded that on TRPV1 capsaicin receptors OLDA is 50 times less potent than capsaicin and it might serve as an endogenous ligand for TRPV1 in the rat, but more likely in humans.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	141-146
15135921-1	2004	The TRPV1 receptor, previously called VR1 receptor, is a non-selective cation channel gated by capsaicin, noxious heat, protons and anandamide.	Capsaicin	95-104	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
15135928-3	2004	NKCC1 KO mice showed an increase in tail flick latencies and a reduction of the duration of pain behavior induced by intradermal capsaicin compared to HE and WT mice.	Capsaicin	129-138	solute carrier family 12, member 2	Mus musculus	0-5
15152030-4	2004	VR1 agonist capsaicin (CAP; 100 nm) reversibly increased EPSC frequency, effects blocked by capsazepine.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-3
15152030-4	2004	VR1 agonist capsaicin (CAP; 100 nm) reversibly increased EPSC frequency, effects blocked by capsazepine.	Capsaicin	23-26	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-3
15094324-1	2004	Agonists of the vanilloid receptor type 1 (VR1), such as capsaicin, induce an analgesic effect following an initial excitatory response.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	16-46
15094324-9	2004	This prolongation of capsaicin-induced analgesia during inflammation was mediated through VR1 since it was completely blocked by coadministration of capsazepine (10 microg).	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	90-93
15094324-12	2004	Overall, these results show that the analgesic effects of capsaicin are importantly enhanced during inflammation, supporting the fact that the stimulation of VR1 could perhaps constitute a suitable strategy to avoid inflammatory hyperalgesia.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	158-161
15128843-2	2004	Transient receptor potential vanilloid subfamily 1 (TRPV1) is a sensory neuron-specific cation channel that responds to capsaicin, protons, or heat stimulus.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
15128843-4	2004	In human embryonic kidney 293 cells expressing TRPV1 and PAR2, PAR2 agonists increased capsaicin- or proton-evoked TRPV1 currents through a PKC-dependent pathway.	Capsaicin	87-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
15140635-0	2004	Cannabidiol lacks the vanilloid VR1-mediated vasorespiratory effects of capsaicin and anandamide in anaesthetised rats.	Capsaicin	72-81	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-35
14701723-0	2004	Distribution and function of the cannabinoid-1 receptor in the modulation of ion transport in the guinea pig ileum: relationship to capsaicin-sensitive nerves.	Capsaicin	132-141	cannabinoid receptor 1	Cavia porcellus	33-55
14701723-7	2004	In the ion-transport studies, I(sc) responses to capsaicin, which activates extrinsic primary afferents, and to electrical field stimulation (EFS) were reduced by pretreatment with the muscarinic antagonist atropine, abolished by tetrodotoxin, but were unaffected by VIP receptor desensitization, hexamethonium, alpha-amino-3-hydroxy-5-methlisoxazole-4-proprionic acid, or N-methyl-d-aspartate glutamate receptor antagonists.	Capsaicin	49-58	VIP peptides	Cavia porcellus	267-270
15174761-2	2004	Vanilloid receptor subtype 1 (VRI) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-34
15174761-2	2004	Vanilloid receptor subtype 1 (VRI) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	43-76
15174761-2	2004	Vanilloid receptor subtype 1 (VRI) and the vanilloid receptor-like protein 1 (VRL-1) are activated, not only by capsaicin, but also by noxious heat and protons, and it has been suggested that they are polymodal nociceptors.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	78-83
15128843-4	2004	In human embryonic kidney 293 cells expressing TRPV1 and PAR2, PAR2 agonists increased capsaicin- or proton-evoked TRPV1 currents through a PKC-dependent pathway.	Capsaicin	87-96	F2R like trypsin receptor 1	Homo sapiens	57-61
15128843-4	2004	In human embryonic kidney 293 cells expressing TRPV1 and PAR2, PAR2 agonists increased capsaicin- or proton-evoked TRPV1 currents through a PKC-dependent pathway.	Capsaicin	87-96	F2R like trypsin receptor 1	Homo sapiens	63-67
15128843-4	2004	In human embryonic kidney 293 cells expressing TRPV1 and PAR2, PAR2 agonists increased capsaicin- or proton-evoked TRPV1 currents through a PKC-dependent pathway.	Capsaicin	87-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	115-120
15128844-2	2004	We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated by capsaicin, protons, and noxious heat, mediates PAR2-induced hyperalgesia.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-71
15128844-2	2004	We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated by capsaicin, protons, and noxious heat, mediates PAR2-induced hyperalgesia.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
15128844-2	2004	We determined whether transient receptor potential vanilloid receptor 1 (TRPV1), a cation channel activated by capsaicin, protons, and noxious heat, mediates PAR2-induced hyperalgesia.	Capsaicin	111-120	F2R like trypsin receptor 1	Homo sapiens	158-162
15128844-4	2004	PAR2 agonists increased intracellular [Ca2+] ([Ca2+]i) in these neurons in culture, and PAR2-responsive neurons also responded to the TRPV1 agonist capsaicin, confirming coexpression of PAR2 and TRPV1.	Capsaicin	148-157	F2R like trypsin receptor 1	Homo sapiens	0-4
15128844-4	2004	PAR2 agonists increased intracellular [Ca2+] ([Ca2+]i) in these neurons in culture, and PAR2-responsive neurons also responded to the TRPV1 agonist capsaicin, confirming coexpression of PAR2 and TRPV1.	Capsaicin	148-157	F2R like trypsin receptor 1	Homo sapiens	88-92
15128844-4	2004	PAR2 agonists increased intracellular [Ca2+] ([Ca2+]i) in these neurons in culture, and PAR2-responsive neurons also responded to the TRPV1 agonist capsaicin, confirming coexpression of PAR2 and TRPV1.	Capsaicin	148-157	transient receptor potential cation channel subfamily V member 1	Homo sapiens	134-139
15128844-4	2004	PAR2 agonists increased intracellular [Ca2+] ([Ca2+]i) in these neurons in culture, and PAR2-responsive neurons also responded to the TRPV1 agonist capsaicin, confirming coexpression of PAR2 and TRPV1.	Capsaicin	148-157	F2R like trypsin receptor 1	Homo sapiens	88-92
15128844-5	2004	PAR2 agonists potentiated capsaicin-induced increases in [Ca2+]i in TRPV1-transfected human embryonic kidney (HEK) cells and DRG neurons and potentiated capsaicin-induced currents in DRG neurons.	Capsaicin	26-35	F2R like trypsin receptor 1	Homo sapiens	0-4
15128844-5	2004	PAR2 agonists potentiated capsaicin-induced increases in [Ca2+]i in TRPV1-transfected human embryonic kidney (HEK) cells and DRG neurons and potentiated capsaicin-induced currents in DRG neurons.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
15128844-5	2004	PAR2 agonists potentiated capsaicin-induced increases in [Ca2+]i in TRPV1-transfected human embryonic kidney (HEK) cells and DRG neurons and potentiated capsaicin-induced currents in DRG neurons.	Capsaicin	153-162	F2R like trypsin receptor 1	Homo sapiens	0-4
15128844-9	2004	Coinjection of nonhyperalgesic doses of PAR2 agonist and capsaicin induced hyperalgesia that was inhibited by deletion of TRPV1 or antagonism of PKC.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
15128844-9	2004	Coinjection of nonhyperalgesic doses of PAR2 agonist and capsaicin induced hyperalgesia that was inhibited by deletion of TRPV1 or antagonism of PKC.	Capsaicin	57-66	proline rich transmembrane protein 2	Homo sapiens	145-148
15128844-10	2004	PAR2 activation also potentiated capsaicin-induced release of substance P and calcitonin gene-related peptide from superfused segments of the dorsal horn of the spinal cord, where they mediate hyperalgesia.	Capsaicin	33-42	F2R like trypsin receptor 1	Homo sapiens	0-4
15128844-10	2004	PAR2 activation also potentiated capsaicin-induced release of substance P and calcitonin gene-related peptide from superfused segments of the dorsal horn of the spinal cord, where they mediate hyperalgesia.	Capsaicin	33-42	tachykinin precursor 1	Homo sapiens	62-73
15475687-1	2004	The vanilloid receptor VR1 (TRPV1) is a temperature- and capsaicin-sensitive cation channel expressed by a class of primary afferents involved in nociception.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	23-26
15003856-0	2004	Activation of protein kinase C reverses capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels.	Capsaicin	40-49	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	95-100
15003856-1	2004	Ca2+ selective ion channels of vanilloid receptor subtype-1 (TRPV1) in capsaicin-sensitive dorsal root ganglion (DRG) neurons and TRPV1 transfected Chinese hamster ovarian (CHO) cells are desensitized following calcium-dependent tachyphylaxis induced by successive applications of 100 nM capsaicin.	Capsaicin	71-80	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	61-66
15003856-1	2004	Ca2+ selective ion channels of vanilloid receptor subtype-1 (TRPV1) in capsaicin-sensitive dorsal root ganglion (DRG) neurons and TRPV1 transfected Chinese hamster ovarian (CHO) cells are desensitized following calcium-dependent tachyphylaxis induced by successive applications of 100 nM capsaicin.	Capsaicin	288-297	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	61-66
15003856-2	2004	Tachyphylaxis of TRPV1 to 100 nM capsaicin stimuli was not observed in the absence of extracellular calcium.	Capsaicin	33-42	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	17-22
15003856-3	2004	Capsaicin sensitivity of desensitized TRPV1 ion channels recovered on application of phorbol-12-myristate-13-acetate (PMA).	Capsaicin	0-9	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	38-43
15003856-4	2004	PMA-induced recovery of desensitized TRPV1 was primarily due to influx of extracellular calcium observed during re-application of capsaicin following desensitization.	Capsaicin	130-139	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	37-42
15003856-7	2004	Reversal of capsaicin-induced desensitization by PMA was prevented by a mutation of TRPV1 where phosphorylation sites serine502 and serine800 were replaced with alanine.	Capsaicin	12-21	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	84-89
15003856-8	2004	This study provides evidence for a role of PKC in reversing capsaicin-induced calcium-dependent desensitization of TRPV1 ion channels.	Capsaicin	60-69	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	115-120
15128292-5	2004	As a result, the molecular determinants that endow TRPV1 with its physiological properties, namely activation by heat, potentiation by extracellular acidic pH, and interaction with vanilloid-like compounds, as well as its permeation properties are being unveiled.	Capsaicin	181-190	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
15128293-2	2004	Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein, a nonselective cation channel that belongs to the large family of TRP ion channels, and is activated by the pungent ingredient of hot chilli peppers, capsaicin.	Capsaicin	269-278	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-101
15128293-2	2004	Endovanilloids are defined as endogenous ligands of the transient receptor potential vanilloid type 1 (TRPV1) protein, a nonselective cation channel that belongs to the large family of TRP ion channels, and is activated by the pungent ingredient of hot chilli peppers, capsaicin.	Capsaicin	269-278	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
15146439-0	2004	Antiinflammatory and analgesic effects of somatostatin released from capsaicin-sensitive sensory nerve terminals in a Freund"s adjuvant-induced chronic arthritis model in the rat.	Capsaicin	69-78	somatostatin	Rattus norvegicus	42-54
15146439-1	2004	OBJECTIVE: We previously demonstrated that somatostatin (SOM) released from the activated peripheral terminals of capsaicin-sensitive primary sensory neurons inhibits acute inflammation and nociception.	Capsaicin	114-123	somatostatin	Rattus norvegicus	43-55
15146439-1	2004	OBJECTIVE: We previously demonstrated that somatostatin (SOM) released from the activated peripheral terminals of capsaicin-sensitive primary sensory neurons inhibits acute inflammation and nociception.	Capsaicin	114-123	somatostatin	Rattus norvegicus	57-60
15146439-12	2004	CONCLUSION: Our data suggest that SOM released into the circulation from capsaicin-sensitive afferents in response to prolonged activation exerts systemic antiinflammatory and analgesic effects.	Capsaicin	73-82	somatostatin	Rattus norvegicus	34-37
14764656-1	2004	We performed a study in spontaneous hypertensive rats (SHR) to determine whether carvedilol, a nonselective beta-adrenoceptor antagonist, activates capsaicin-sensitive sensory neurons (CSSNs), thereby promoting the release of calcitonin gene-related peptide (CGRP), a neuropeptide with an important role in maintenance of cardiovascular homeostasis.	Capsaicin	148-157	calcitonin-related polypeptide alpha	Rattus norvegicus	226-257
15475687-1	2004	The vanilloid receptor VR1 (TRPV1) is a temperature- and capsaicin-sensitive cation channel expressed by a class of primary afferents involved in nociception.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	28-33
15071115-12	2004	Increasing the concentrations of capsaicin reversed the inhibitory response to capsaicin, suggesting a competitive inhibition at TRPV1.	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	129-134
14960593-1	2004	The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-29
14960593-1	2004	The vanilloid receptor 1 (VR1 or TRPV1) ion channel is activated by noxious heat, low pH and by a variety of vanilloid-related compounds.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-38
14960593-3	2004	Mutation of rat TRPV1 at three positions in the S3 to S4 region, to the corresponding human amino acid residues I514M, V518L, and M547L decreased the IC(50) values for capsazepine inhibition of the pH 5.5 response from >10,000 nm to 924 +/- 241 nm in [Ca(2+)](i) assays and increased capsazepine inhibition of the capsaicin response to levels seen for human TRPV1.	Capsaicin	317-326	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	16-21
15071115-10	2004	Furthermore, specific capsaicin-sensitive binding of [(3)H]CGS21680 was observed in Xenopus oocyte membranes expressing TRPV1.	Capsaicin	22-31	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	120-125
15071115-12	2004	Increasing the concentrations of capsaicin reversed the inhibitory response to capsaicin, suggesting a competitive inhibition at TRPV1.	Capsaicin	33-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	129-134
15071115-13	2004	Finally, exposure of HEK/TRPV1 cells to capsaicin induced an approximately 2.4-fold increase in proapoptotic cells that was abolished by adenosine analogs.	Capsaicin	40-49	EPH receptor A3	Homo sapiens	21-24
15071115-13	2004	Finally, exposure of HEK/TRPV1 cells to capsaicin induced an approximately 2.4-fold increase in proapoptotic cells that was abolished by adenosine analogs.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-30
15006899-7	2004	The TRPV1 antagonists iodo-resiniferatoxin (I-RTX) and capsazepine (CPZ) each obtunded AEA-, NADA-, ACEA- and capsaicin (CAP)-evoked CGRP release with individually equivalent IC(50)"s for each of the compounds (I-RTX IC(50) range=2.6-4.0 nM; CPZ IC(50) range=523-1140 microM).	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
15006899-7	2004	The TRPV1 antagonists iodo-resiniferatoxin (I-RTX) and capsazepine (CPZ) each obtunded AEA-, NADA-, ACEA- and capsaicin (CAP)-evoked CGRP release with individually equivalent IC(50)"s for each of the compounds (I-RTX IC(50) range=2.6-4.0 nM; CPZ IC(50) range=523-1140 microM).	Capsaicin	121-124	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
15080816-4	2004	OBJECTIVE: The aim of this study was to examine ASC in atopic patients and relate it to cough reaction to capsaicin inhalation.	Capsaicin	106-115	PYD and CARD domain containing	Homo sapiens	48-51
15242019-0	2004	Expressional changes of neuropeptide Y and cholecystokinin in the arcuate and paraventricular nuclei after capsaicin administration.	Capsaicin	107-116	neuropeptide Y	Rattus norvegicus	24-38
15190937-7	2004	The expression of Rac1N17, a dominant negative mutant of Rac1, also significantly inhibited the capsaicin-induced apoptosis.	Capsaicin	96-105	Rac family small GTPase 1	Homo sapiens	18-22
14657192-5	2004	The reasons for investigating its effects on capsaicin-activated TRPV1 channels are to understand how it may modulate this channel that is involved in pain, inflammation, and gustatory physiology.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
14657192-8	2004	Nicotine also modulates TRPV1 receptors inducing a several-fold increase in capsaicin-activated currents in both TG neurons and in cells with heterologously expressed TRPV1 receptors.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
14657192-8	2004	Nicotine also modulates TRPV1 receptors inducing a several-fold increase in capsaicin-activated currents in both TG neurons and in cells with heterologously expressed TRPV1 receptors.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	167-172
14657192-11	2004	In this regard, its effect on TRPV1 receptors differs from those of ethanol that has been shown to increase the capsaicin-activated current but decrease the threshold temperature.	Capsaicin	112-121	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-35
15098930-0	2004	Role of vanilloid receptors in the capsaicin-mediated induction of iNOS in PC12 cells.	Capsaicin	35-44	nitric oxide synthase 2	Rattus norvegicus	67-71
15098930-4	2004	Capsaicin (CPS), the VRI receptor agonist, led to an increase in intracellular calcium ion, and this effect was blocked by pretreatment with VR1 receptor antagonist capsazepin (CPZ).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	141-144
15098930-4	2004	Capsaicin (CPS), the VRI receptor agonist, led to an increase in intracellular calcium ion, and this effect was blocked by pretreatment with VR1 receptor antagonist capsazepin (CPZ).	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	141-144
15098930-5	2004	Treatment of PC12 cells with low concentration of CPS (5-50 microM) increased reactive oxygen species (ROS) production, and inducible nitric oxide synthase (iNOS) was expressed after CPS treatment for 24 h. These CPS-induced changes are inhibited by pretreatment of CPZ.	Capsaicin	50-53	nitric oxide synthase 2	Rattus norvegicus	124-155
15098930-5	2004	Treatment of PC12 cells with low concentration of CPS (5-50 microM) increased reactive oxygen species (ROS) production, and inducible nitric oxide synthase (iNOS) was expressed after CPS treatment for 24 h. These CPS-induced changes are inhibited by pretreatment of CPZ.	Capsaicin	183-186	nitric oxide synthase 2	Rattus norvegicus	124-155
15098930-5	2004	Treatment of PC12 cells with low concentration of CPS (5-50 microM) increased reactive oxygen species (ROS) production, and inducible nitric oxide synthase (iNOS) was expressed after CPS treatment for 24 h. These CPS-induced changes are inhibited by pretreatment of CPZ.	Capsaicin	183-186	nitric oxide synthase 2	Rattus norvegicus	157-161
15098930-5	2004	Treatment of PC12 cells with low concentration of CPS (5-50 microM) increased reactive oxygen species (ROS) production, and inducible nitric oxide synthase (iNOS) was expressed after CPS treatment for 24 h. These CPS-induced changes are inhibited by pretreatment of CPZ.	Capsaicin	183-186	nitric oxide synthase 2	Rattus norvegicus	124-155
15098930-5	2004	Treatment of PC12 cells with low concentration of CPS (5-50 microM) increased reactive oxygen species (ROS) production, and inducible nitric oxide synthase (iNOS) was expressed after CPS treatment for 24 h. These CPS-induced changes are inhibited by pretreatment of CPZ.	Capsaicin	183-186	nitric oxide synthase 2	Rattus norvegicus	157-161
15098930-6	2004	These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system.	Capsaicin	28-31	nitric oxide synthase 2	Rattus norvegicus	40-44
15080816-9	2004	The patients with ASC were older (P<0.01) and coughed significantly more on capsaicin provocation (P<0.001), but did not differ from them with respect to the allergic disease or its treatment or to smoking habits.	Capsaicin	79-88	PYD and CARD domain containing	Homo sapiens	18-21
15080816-11	2004	The scored degree of ASC was directly related to the number of coughs during the capsaicin provocation.	Capsaicin	81-90	PYD and CARD domain containing	Homo sapiens	21-24
14987622-3	2004	The vanilloid receptor VR1 (TRPV1) is expressed by nociceptors, and is triggered by capsaicin, noxious heat, protons, and chemicals produced during inflammation.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-26
14987622-3	2004	The vanilloid receptor VR1 (TRPV1) is expressed by nociceptors, and is triggered by capsaicin, noxious heat, protons, and chemicals produced during inflammation.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
15099451-3	2004	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	65-96
15099451-3	2004	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	98-102
15099451-3	2004	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP) and substance P in the stomach.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	108-119
15066018-6	2004	Pretreatment with capsaicin or hexamethonium, combination of both pretreatments or vagotomy reduced HCl-induced c-Fos expression by 54%, 66%, 63% and 68%, respectively.	Capsaicin	18-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	112-117
15098930-6	2004	These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system.	Capsaicin	28-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-71
15098930-6	2004	These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system.	Capsaicin	28-31	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	79-83
15242019-0	2004	Expressional changes of neuropeptide Y and cholecystokinin in the arcuate and paraventricular nuclei after capsaicin administration.	Capsaicin	107-116	cholecystokinin	Rattus norvegicus	43-58
15098930-6	2004	These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system.	Capsaicin	127-130	nitric oxide synthase 2	Rattus norvegicus	40-44
15098930-6	2004	These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system.	Capsaicin	127-130	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-71
15242019-3	2004	There was a significantly lower concentration of NPY immunopositive cells in the arcuate and paraventricular nuclei of the capsaicin treated rats.	Capsaicin	123-132	neuropeptide Y	Rattus norvegicus	49-52
15098930-6	2004	These findings suggest that CPS-induced iNOS expression through the VR1 and/or VRL1-mediated pathway, and this may explain the CPS-mediated physiological and pathological effects in neuron system.	Capsaicin	127-130	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	79-83
15242019-4	2004	In contrast, the CCK expressions level was higher in the paraventricular nucleus of the capsaicin treated rats than in the control rats.	Capsaicin	88-97	cholecystokinin	Rattus norvegicus	17-20
15242019-5	2004	These results suggest that capsaicin influence neuropeptides such as orexigenic NPY and anorexigenic CCK related to control food intake.	Capsaicin	27-36	neuropeptide Y	Rattus norvegicus	80-83
15242019-5	2004	These results suggest that capsaicin influence neuropeptides such as orexigenic NPY and anorexigenic CCK related to control food intake.	Capsaicin	27-36	cholecystokinin	Rattus norvegicus	101-104
15033390-9	2004	When the tissue was contracted for 20 min with acetylcholine, MLC(20) phosphorylation was increased, and capsaicin reduced markedly the contraction and abolished MLC(20) phosphorylation both elicited by acetylcholine.	Capsaicin	105-114	myosin light chain 12B	Rattus norvegicus	162-168
15046718-2	2004	The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
15046718-2	2004	The natural compounds capsaicin and menthol activate noxious heat-sensitive TRPV1 and cold-sensitive TRPM8, respectively.	Capsaicin	22-31	transient receptor potential cation channel subfamily M member 8	Homo sapiens	101-106
15033390-1	2004	The mechanisms underlying the capsaicin-induced relaxation of the acetylcholine- as well as KCl-contraction were studied by measuring isometric force and phosphorylation of 20-kDa regulatory light chain subunit of myosin (MLC(20)) in ileal longitudinal smooth muscles of rats.	Capsaicin	30-39	myosin light chain 12B	Rattus norvegicus	222-229
14749037-0	2004	Capsaicin-sensitive neural pathway mediates atrial natriuretic factor (ANF) release in response to physiological stimuli.	Capsaicin	0-9	natriuretic peptide A	Rattus norvegicus	44-69
14749037-0	2004	Capsaicin-sensitive neural pathway mediates atrial natriuretic factor (ANF) release in response to physiological stimuli.	Capsaicin	0-9	natriuretic peptide A	Rattus norvegicus	71-74
14749037-8	2004	We conclude (A) that local application of capsaicin to the heart of adult rats induces selective functional neural deficits and (B) that information regarding distension of the junction of the great veins and the atria is normally transmitted across the atrium via these nerves to stimulate ANF secretion from peptide stores located in the atrial appendage.	Capsaicin	42-51	natriuretic peptide A	Rattus norvegicus	291-294
15033390-11	2004	The effects of capsaicin on acetylcholine- and KCl-induced contraction could be explained by a decrease in MLC(20) phosphorylation.	Capsaicin	15-24	myosin light chain 12B	Rattus norvegicus	107-113
15016092-6	2004	Consistent with the involvement of TRPV1, these proton-evoked currents were blocked by capsazepine and were only found in neurons that responded to capsaicin with an increase in membrane conductance.	Capsaicin	148-157	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-40
14604857-8	2004	Capsaicin, SP, and CGRP lowered P(if) significantly (P < 0.05) compared with vehicle and to the same extent in both NDST-2(+/+) and NDST-2(-/-) mice.	Capsaicin	0-9	N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 2	Mus musculus	135-141
15161056-1	2004	Capsaicin specifically activates or destroys small diameter nociceptive sensory neurons that contain the capsaicin receptor, also called vanilloid receptor 1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	105-123
15161056-1	2004	Capsaicin specifically activates or destroys small diameter nociceptive sensory neurons that contain the capsaicin receptor, also called vanilloid receptor 1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	137-157
14769783-2	2004	We have investigated the vascular effects of N-arachidonoyl-dopamine (NADA), a novel endocannabinoid/vanilloid.	Capsaicin	101-110	dopamine receptor D1	Homo sapiens	60-69
14967737-8	2004	On the other hand, the TRPV1 antagonist capsazepine inhibited both capsaicin- and BK-mediated nociception.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
14987252-1	2004	The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes in vitro and in vivo.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-32
14987252-1	2004	The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes in vitro and in vivo.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-37
14987252-1	2004	The vanilloid receptor subtype 1 (VR1)/(TRPV1), binding capsaicin, is a non-selective cation channel that recently has been shown in human keratinocytes in vitro and in vivo.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
14987252-6	2004	In pruritic skin of PN, VR1 expression was highly increased in epidermal keratinocytes and nerve fibers, which was normalized after capsaicin application.	Capsaicin	132-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-27
14987252-7	2004	During capsaicin therapy, a reduction of neuropeptides (substance P, calcitonin gene-related peptide) was observed.	Capsaicin	7-16	tachykinin precursor 1	Homo sapiens	56-67
15016100-2	2004	Capsaicin-desensitized wild-mice exhibited an even higher DBT amplitude than did TRPV1 deficient mice.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	81-86
15037813-0	2004	Modulation of capsaicin-evoked visceral pain and referred hyperalgesia by protease-activated receptors 1 and 2.	Capsaicin	14-23	coagulation factor II (thrombin) receptor-like 1	Mus musculus	74-110
14617692-5	2004	Depletion of primary afferent nerve fibers by neonatal capsaicin treatment prevented CD95-mediated activation of caspase-3, measured as enzymatic activity in liver homogenates or by demonstration of hepatocellular immunoreactivity for active caspase-3 in liver slices, and liver damage.	Capsaicin	55-64	Fas (TNF receptor superfamily member 6)	Mus musculus	85-89
14617692-5	2004	Depletion of primary afferent nerve fibers by neonatal capsaicin treatment prevented CD95-mediated activation of caspase-3, measured as enzymatic activity in liver homogenates or by demonstration of hepatocellular immunoreactivity for active caspase-3 in liver slices, and liver damage.	Capsaicin	55-64	caspase 3	Mus musculus	113-122
14617692-5	2004	Depletion of primary afferent nerve fibers by neonatal capsaicin treatment prevented CD95-mediated activation of caspase-3, measured as enzymatic activity in liver homogenates or by demonstration of hepatocellular immunoreactivity for active caspase-3 in liver slices, and liver damage.	Capsaicin	55-64	caspase 3	Mus musculus	242-251
15037813-8	2004	SLIGRL-NH2, a PAR-2-activating peptide, but not LRGILS-NH2, a control peptide, administered i.col., facilitated the capsaicin-evoked visceral nociception 6-18 h after administration, while i.p.	Capsaicin	116-125	pulmonary adenoma resistance 2	Mus musculus	14-19
15082876-10	2004	The IP-induced protection and hyperemia were restored by the administration of exogenous CGRP to gastric IP in capsaicin-treated animals.	Capsaicin	111-120	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
14975683-7	2004	The neonatal treatment with capsaicin, polygodial or drimanial significantly decreased [3H]-resiniferatoxin binding sites in the rat spinal cord, but only capsaicin neonatal treatment significantly reduced the expression of TRPV1 in dorsal root ganglia (DRG) when assessed by Western blot.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	224-229
15082877-10	2004	Capsaicin-induced ablation of sensory neurons significantly delayed ulcer healing and this was accompanied by the significant fall in the GBF and the significant rise in the gastric mucosal gene expression of IL-1beta and TNF-alpha.	Capsaicin	0-9	interleukin 1 beta	Rattus norvegicus	209-217
15082877-10	2004	Capsaicin-induced ablation of sensory neurons significantly delayed ulcer healing and this was accompanied by the significant fall in the GBF and the significant rise in the gastric mucosal gene expression of IL-1beta and TNF-alpha.	Capsaicin	0-9	tumor necrosis factor	Rattus norvegicus	222-231
14975683-7	2004	The neonatal treatment with capsaicin, polygodial or drimanial significantly decreased [3H]-resiniferatoxin binding sites in the rat spinal cord, but only capsaicin neonatal treatment significantly reduced the expression of TRPV1 in dorsal root ganglia (DRG) when assessed by Western blot.	Capsaicin	155-164	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	224-229
14718253-7	2004	Anti-BDNF blocked enhanced reactivity in response to capsaicin, but not airway smooth muscle hyper-reactivity in vivo.	Capsaicin	53-62	brain derived neurotrophic factor	Mus musculus	5-9
14694538-10	2004	Resiniferatoxin reduced CYP-induced up-regulation of p-CREB in DRG, suggesting that cystitis can reveal an altered CREB phosphorylation that may be mediated by capsaicin-sensitive bladder afferents.	Capsaicin	160-169	cAMP responsive element binding protein 1	Homo sapiens	115-119
14707011-5	2004	In contrast, in capsaicin-pretreated mice, GLP-1 at 0.1 nmol/kg could not augment the insulin response to intravenous glucose and no effect on glucose elimination was observed.	Capsaicin	16-25	glucagon	Mus musculus	43-48
14707011-6	2004	Nevertheless, at the high dose of 10 nmol/kg, GLP-1 augmented the insulin response to glucose in capsaicin-pretreated mice as efficiently as in control mice.	Capsaicin	97-106	glucagon	Mus musculus	46-51
14630912-3	2004	Here we show that VR1 must be phosphorylated by Ca2+-calmodulin dependent kinase II (CaMKII) before its activation by capsaicin.	Capsaicin	118-127	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-21
14634201-1	2004	The vanilloid receptor TRPV1 (formerly VR1) has been implicated in the activation of nociceptive sensory nerves by capsaicin, noxious heat, protons, bradykinin, cannabinoids such as anandamide, and certain metabolites of arachidonic acid.	Capsaicin	115-124	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
14634201-1	2004	The vanilloid receptor TRPV1 (formerly VR1) has been implicated in the activation of nociceptive sensory nerves by capsaicin, noxious heat, protons, bradykinin, cannabinoids such as anandamide, and certain metabolites of arachidonic acid.	Capsaicin	115-124	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	39-42
14634201-4	2004	Capsaicin (1 microm) evoked action potential discharge of approximately 90% (28/31) of C-fibres in the TRPV1+/+ mice, but failed to activate bronchopulmonary C-fibres in TRPV1-/- animals (n = 10).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	103-108
14634201-5	2004	Anandamide (3-100 microm) induced concentration-dependent activation of capsaicin-sensitive TRPV1+/+ C-fibres with a threshold of 3-10 microm, but failed to evoke substantive discharge in TRPV1-/- C-fibres.	Capsaicin	72-81	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-97
14634201-6	2004	In the TRPV1+/+ mice, the B2 receptor-mediated activation by bradykinin (1 microm) was restricted to the capsaicin-sensitive C-fibres.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	7-12
14634201-9	2004	We conclude that TRPV1 is obligatory for vagal C-fibre activation by capsaicin and anandamide.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	17-22
14871840-0	2004	Induction of apoptosis in leukemic cells by homovanillic acid derivative, capsaicin, through oxidative stress: implication of phosphorylation of p53 at Ser-15 residue by reactive oxygen species.	Capsaicin	74-83	tumor protein p53	Homo sapiens	145-148
14871840-7	2004	Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin.	Capsaicin	15-24	tumor protein p53	Homo sapiens	78-81
14871840-7	2004	Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin.	Capsaicin	15-24	tumor protein p53	Homo sapiens	119-122
14871840-7	2004	Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin.	Capsaicin	165-174	tumor protein p53	Homo sapiens	78-81
14871840-7	2004	Interestingly, capsaicin-sensitive leukemic cells were possessed of wild-type p53, resulting in the phosphorylation of p53 at the Ser-15 residue by the treatment of capsaicin.	Capsaicin	165-174	tumor protein p53	Homo sapiens	119-122
14871840-8	2004	Abrogation of p53 expression by the antisense oligonucleotides significantly attenuated capsaicin-induced cell cycle arrest and apoptosis.	Capsaicin	88-97	tumor protein p53	Homo sapiens	14-17
14871840-9	2004	Pretreatment with the antioxidant N-acetyl-L-cystein and catalase, but not superoxide dismutase, completely inhibited capsaicin-induced apoptosis by inhibiting phosphorylation of Ser-15 residue of p53.	Capsaicin	118-127	tumor protein p53	Homo sapiens	197-200
12832496-3	2004	P2X(3) subunits are found in a subset of small-diameter, primary afferent neurones, some of which are also sensitive to capsaicin.	Capsaicin	120-129	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	0-6
15076747-0	2004	Capsaicin increases GFAP and glutamine synthetase immunoreactivity in rat arcuate nucleus and median eminence.	Capsaicin	0-9	glial fibrillary acidic protein	Rattus norvegicus	20-24
15076747-0	2004	Capsaicin increases GFAP and glutamine synthetase immunoreactivity in rat arcuate nucleus and median eminence.	Capsaicin	0-9	glutamate-ammonia ligase	Rattus norvegicus	29-49
15076747-2	2004	Compared to vehicle, capsaicin significantly increased GFAP and GS immunoreactivity in the ARC-ME.	Capsaicin	21-30	glial fibrillary acidic protein	Rattus norvegicus	55-59
15076747-4	2004	Since GS is primarily responsible for glutamate-glutamine metabolism, the increase in total immunostaining for GFAP-and GS- staining suggests a functional adjustment to cope with some of the capsaicin-induced effects.	Capsaicin	191-200	glial fibrillary acidic protein	Rattus norvegicus	111-115
15031536-0	2004	Effect of capsaicin on cholecystokinin and neuropeptide Y expressions in the brain of high-fat diet fed rats.	Capsaicin	10-19	neuropeptide Y	Rattus norvegicus	43-57
15031536-3	2004	This study was carried out to investigate the effect of capsaicin on CCK- and NPY- immunoreactivities (IR) in the brain of high-fat fed rats.	Capsaicin	56-65	cholecystokinin	Rattus norvegicus	69-72
15031536-3	2004	This study was carried out to investigate the effect of capsaicin on CCK- and NPY- immunoreactivities (IR) in the brain of high-fat fed rats.	Capsaicin	56-65	neuropeptide Y	Rattus norvegicus	78-81
15031536-10	2004	It is concluded that (1) NPY-IR may react more sensitively on capsaicin than CCK-IR, (2) no rapid increase of body weight in capsaicin treated rats may result from the diminished food intake through the low expression of NPY in hypothalamus in HF-CAP group.	Capsaicin	62-71	neuropeptide Y	Rattus norvegicus	25-28
14742669-2	2004	IBTU competitively inhibited 45Ca2+ uptake into CHO cells heterologously expressing rat TRPV1, whether induced by capsaicin or resiniferatoxin (Ki = 99 +/- 23 and 93 +/- 34 nM, respectively).	Capsaicin	114-123	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	88-93
14744780-4	2004	In vitro, capsaicin inhibited vascular endothelial growth factor (VEGF) -induced proliferation, DNA synthesis, chemotactic motility, and capillary-like tube formation of primary cultured human endothelial cells.	Capsaicin	10-19	vascular endothelial growth factor A	Homo sapiens	30-64
14744780-4	2004	In vitro, capsaicin inhibited vascular endothelial growth factor (VEGF) -induced proliferation, DNA synthesis, chemotactic motility, and capillary-like tube formation of primary cultured human endothelial cells.	Capsaicin	10-19	vascular endothelial growth factor A	Homo sapiens	66-70
14744780-5	2004	Capsaicin inhibited both VEGF-induced vessel sprouting in rat aortic ring assay and VEGF-induced vessel formation in the mouse Matrigel plug assay.	Capsaicin	0-9	vascular endothelial growth factor A	Rattus norvegicus	25-29
14744780-5	2004	Capsaicin inhibited both VEGF-induced vessel sprouting in rat aortic ring assay and VEGF-induced vessel formation in the mouse Matrigel plug assay.	Capsaicin	0-9	vascular endothelial growth factor A	Rattus norvegicus	84-88
14744780-9	2004	Signaling experiments show that capsaicin inhibits VEGF-induced p38 mitogen-activated protein kinase, p125(FAK), and AKT activation, but its molecular target is distinct from the VEGF receptor KDR/Flk-1.	Capsaicin	32-41	vascular endothelial growth factor A	Homo sapiens	51-55
14744780-9	2004	Signaling experiments show that capsaicin inhibits VEGF-induced p38 mitogen-activated protein kinase, p125(FAK), and AKT activation, but its molecular target is distinct from the VEGF receptor KDR/Flk-1.	Capsaicin	32-41	mitogen-activated protein kinase 14	Homo sapiens	64-67
14744780-9	2004	Signaling experiments show that capsaicin inhibits VEGF-induced p38 mitogen-activated protein kinase, p125(FAK), and AKT activation, but its molecular target is distinct from the VEGF receptor KDR/Flk-1.	Capsaicin	32-41	SEC23 interacting protein	Homo sapiens	102-106
14744780-9	2004	Signaling experiments show that capsaicin inhibits VEGF-induced p38 mitogen-activated protein kinase, p125(FAK), and AKT activation, but its molecular target is distinct from the VEGF receptor KDR/Flk-1.	Capsaicin	32-41	protein tyrosine kinase 2	Homo sapiens	107-110
14744780-9	2004	Signaling experiments show that capsaicin inhibits VEGF-induced p38 mitogen-activated protein kinase, p125(FAK), and AKT activation, but its molecular target is distinct from the VEGF receptor KDR/Flk-1.	Capsaicin	32-41	AKT serine/threonine kinase 1	Homo sapiens	117-120
14672807-2	2004	The radiolabelled vanilloid agonist [3H]resiniferatoxin (RTX) has been used to indicate the presence of TRPV1 receptor protein in the brain but low specific binding has complicated interpretation of this data.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	104-109
15706060-0	2004	tNOX is both necessary and sufficient as a cellular target for the anticancer actions of capsaicin and the green tea catechin (-)-epigallocatechin-3-gallate.	Capsaicin	89-98	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	0-4
15112866-6	2004	When the nociceptive laser pulses were applied to the capsaicin pre-treated skin, ReN1869 exerted a highly significant reduction of the pain response--as predominantly detected by suppression of the (central) P2-component in the laser-induced somatosensory evoked potentials (LSEPs) from Vertex-EEG.	Capsaicin	54-63	renin	Homo sapiens	82-85
15706060-1	2004	Capsaicin and the principal green tea catechin, (-)-epigallocatechin-3-gallate (EGCg), target tNOX, a tumor (cancer)-specific surface hydroquinone (NADH) oxidase with protein disulfide-thiol interchange activity (ECTO-NOX protein).	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	94-98
15706060-2	2004	Accordingly vector-forced over expression of tNOX in MCF-10A mammary epithelia or COS cells that lack tNOX or in COS cells that underexpress tNOX enhanced the susceptibility of growth and apoptosis to both EGCg and capsaicin.	Capsaicin	215-224	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	45-49
15706060-4	2004	In contrast, oligomeric antisense tNOX DNA abrogated growth inhibition by EGCg and capsaicin and reduced anchorage-dependent growth of HeLa (human cervical carcinoma) cells that naturally overexpress tNOX.	Capsaicin	83-92	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	34-38
15706060-5	2004	The findings show cell surface expression of tNOX as both necessary and sufficient for the cellular anticancer activities attributed to both EGCg and capsaicin.	Capsaicin	150-159	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	45-49
15732761-1	2004	Capsaicin (Sigma, 5 mg/l ml) was unilaterally injected into dorsal neck muscles (mm.	Capsaicin	0-9	adaptor related protein complex 5 subunit sigma 1	Homo sapiens	11-19
14662737-9	2004	However, the PACAP 38 relaxations were reduced by omega-CgTX, capsaicin, l-NOARG and ODQ.	Capsaicin	62-71	adenylate cyclase activating polypeptide 1	Sus scrofa	13-18
14651947-1	2004	Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined.	Capsaicin	113-122	interleukin 6	Homo sapiens	137-150
14651947-1	2004	Effects of three experimental manipulations: mental stress, relaxation, and a nociceptive inflammatory stimulus, capsaicin, on levels of interleukin-6 (IL-6) were examined.	Capsaicin	113-122	interleukin 6	Homo sapiens	152-156
14651947-6	2004	Small but significant increases in IL-6 were seen at 60 min post-capsaicin.	Capsaicin	65-74	interleukin 6	Homo sapiens	35-39
15732761-4	2004	In comparison to sham operated animals (n = 2), 2 h after capsaicin injection the significant c-fos expression was found throughout the cervical cord (C1 - C8) ipsilaterally and lumbar cord bilaterally (L1 - L7), while the predominant mean number of Fos-ir neurons was detected in the C1 - C4 and L3-L6 segments.	Capsaicin	58-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	94-99
15732761-4	2004	In comparison to sham operated animals (n = 2), 2 h after capsaicin injection the significant c-fos expression was found throughout the cervical cord (C1 - C8) ipsilaterally and lumbar cord bilaterally (L1 - L7), while the predominant mean number of Fos-ir neurons was detected in the C1 - C4 and L3-L6 segments.	Capsaicin	58-67	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	250-253
14569068-7	2004	The mucosal damage induced by the COX-1 inhibitor, the COX-2 inhibitors, and dexamethasone in L-NAME- or capsaicin-treated rats was reversed by coadministration of 16,16-dimethyl-prostaglandin E2 (2 x 8 ng/kg).	Capsaicin	105-114	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	34-39
14699077-0	2004	Ca2+/calmodulin modulates TRPV1 activation by capsaicin.	Capsaicin	46-55	calmodulin 1	Homo sapiens	5-15
14699077-0	2004	Ca2+/calmodulin modulates TRPV1 activation by capsaicin.	Capsaicin	46-55	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-31
14699077-1	2004	TRPV1 ion channels mediate the response to painful heat, extracellular acidosis, and capsaicin, the pungent extract from plants in the Capsicum family (hot chili peppers) (Szallasi, A., and P.M. Blumberg.	Capsaicin	85-94	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
14699077-11	2004	The convergence of these stimuli on TRPV1 channels expressed in peripheral sensory nerves underlies the common perceptual experience of pain due to hot temperatures, tissue damage and exposure to capsaicin.	Capsaicin	196-205	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-41
14699077-30	2004	Here we show that in inside-out excised patches from TRPV1 expressed in Xenopus oocytes and HEK 293 cells, Ca2+/calmodulin decreased the capsaicin-activated current.	Capsaicin	137-146	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	53-58
14699077-30	2004	Here we show that in inside-out excised patches from TRPV1 expressed in Xenopus oocytes and HEK 293 cells, Ca2+/calmodulin decreased the capsaicin-activated current.	Capsaicin	137-146	calmodulin 1	Homo sapiens	112-122
14569068-7	2004	The mucosal damage induced by the COX-1 inhibitor, the COX-2 inhibitors, and dexamethasone in L-NAME- or capsaicin-treated rats was reversed by coadministration of 16,16-dimethyl-prostaglandin E2 (2 x 8 ng/kg).	Capsaicin	105-114	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	55-60
14654105-1	2004	Vanilloid receptor-1 (TRPV1) is a non-selective cation channel, predominantly expressed by peripheral sensory neurones, which is known to play a key role in the detection of noxious painful stimuli, such as capsaicin, acid and heat.	Capsaicin	207-216	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
15067207-0	2004	Neonatal capsaicin treatment affects rat thymocyte proliferation and cell death by modulating substance P and neurokinin-1 receptor expression.	Capsaicin	9-18	tachykinin receptor 1	Rattus norvegicus	110-131
15067207-1	2004	Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death.	Capsaicin	159-168	tachykinin receptor 1	Rattus norvegicus	57-78
14654105-6	2004	In electrophysiological experiments, SB-366791 was demonstrated to be an effective antagonist of hTRPV1 when activated by different modalities, such as capsaicin, acid or noxious heat (50 degrees C).	Capsaicin	152-161	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-103
15067207-1	2004	Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death.	Capsaicin	159-168	tachykinin receptor 1	Rattus norvegicus	80-85
15067207-1	2004	Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death.	Capsaicin	170-173	tachykinin receptor 1	Rattus norvegicus	57-78
15067207-1	2004	Herein we provide evidence that substance P (SP) and its neurokinin-1 receptor (NK-1R) expressed on thymocytes counteract thymus depletion induced by neonatal capsaicin (CPS) treatment by affecting thymocyte proliferation and apoptotic death.	Capsaicin	170-173	tachykinin receptor 1	Rattus norvegicus	80-85
15062987-6	2004	An activating dose of capsaicin (2.5%) induced a large oedema in C57BL/6 wild-type mice that was minimal in TRPV1 receptor knockout mice.	Capsaicin	22-31	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
15067207-2	2004	SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration.	Capsaicin	31-34	Cd4 molecule	Rattus norvegicus	125-128
15067207-2	2004	SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration.	Capsaicin	31-34	Cd4 molecule	Rattus norvegicus	134-137
15067207-2	2004	SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration.	Capsaicin	31-34	tachykinin receptor 1	Rattus norvegicus	180-185
15067207-2	2004	SP administration reversed the CPS-mediated inhibitory effects on the total thymocyte number and subset distribution, namely CD4+ and CD4- CD8- cells, through its interaction with NK-1R as shown by concomitant NK-1R (SR140333) antagonist administration.	Capsaicin	31-34	tachykinin receptor 1	Rattus norvegicus	210-215
15067207-8	2004	By contrast, NK-1R mRNA levels were increased in thymocytes from CPS-treated rats.	Capsaicin	65-68	tachykinin receptor 1	Rattus norvegicus	13-18
15067207-9	2004	Exogenous SP administration augmented PPT-A, SP and NK-1R thymocyte expression in CPS-treated rats, and this enhancement was antagonized by SR140333 administration.	Capsaicin	82-85	tachykinin receptor 1	Rattus norvegicus	52-57
15067207-10	2004	Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells.	Capsaicin	84-87	tachykinin receptor 1	Rattus norvegicus	182-187
15067207-10	2004	Overall, our results strongly suggest that the immunomodulatory effects of neonatal CPS treatment on rat thymocyte functions are dependent on vanilloid-mediated regulation of SP and NK-1R functional expression by neuronal and immune cells.	Capsaicin	142-151	tachykinin receptor 1	Rattus norvegicus	182-187
14698742-0	2004	Involvement of peripheral neuropeptide Y receptors in sympathetic modulation of acute cutaneous flare induced by intradermal capsaicin.	Capsaicin	125-134	neuropeptide Y	Rattus norvegicus	26-40
15026132-1	2004	Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea.	Capsaicin	23-32	tachykinin precursor 1	Homo sapiens	43-54
15026132-1	2004	Evidence suggests that capsaicin-sensitive substance P (SP)-containing trigeminal ganglion neurons innervate the spiral modiolar artery (SMA), radiating arterioles, and the stria vascularis of the cochlea.	Capsaicin	23-32	tachykinin precursor 1	Homo sapiens	56-58
15450360-14	2004	These results indicate that peripheral secretin activates catecholaminergic NTS neurons as well as neurons in medullary, pontine and limbic nuclei regulating autonomic functions and emotion through vagal-dependent capsaicin-resistant pathways.	Capsaicin	214-223	secretin	Rattus norvegicus	39-47
14706790-4	2004	Intrathecal administration of the neurokinin-1 receptor antagonist, (3aR,7aR)-7,7-diphenyl-2-(1-imino-2(2-methoxyphenyl)-ethyl) perhydroisoindol-4-1 hydrochloride or the N-methyl-D-aspartate receptor antagonist, DL-2-amino-5-phosphonovaleric acid, both antagonists of the action of primary afferent neurotransmitters, markedly attenuated the inhibition of bradykinin-induced plasma extravasation produced by both intrathecal nicotine and intraplantar capsaicin.Conversely, intrathecal administration of an alpha-adrenoceptor antagonist, phentolamine or an opioid receptor antagonist, naloxone, to block descending antinociceptive controls, which provide inhibitory input to primary afferent nociceptors, enhanced the action of both nicotine and capsaicin.	Capsaicin	451-460	tachykinin receptor 1	Rattus norvegicus	34-55
15283452-5	2004	TRPV1 and ANKTM1 are mediating the pungency of nociceptor-specific chemicals such as capsaicin or mustard oil.	Capsaicin	85-94	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
15183508-2	2004	In this study we demonstrate that similar functions, including capsaicin-induced CGRP release, are to be found in the desheathed sciatic nerve of the mouse.	Capsaicin	63-72	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	81-85
15183508-7	2004	After capsaicin stimulation (10(-6) M for 5 min), the fibers appeared depleted of CGRP with only few vesicles remaining as well as some residual staining of the axoplasm.	Capsaicin	6-15	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	82-86
15283965-8	2004	The increase in intracellular Ca(2+) induced by capsaicin was also slightly greater in IB4+ neurons and in these cells its magnitude correlated with the level of TRPV1 immunoreactivity.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	162-167
15283965-11	2004	Our results also highlight differences in capsaicin responses between IB4+ and IB4- small neurons and reveal the close link between capsaicin responses and levels of TRPV1 expression.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	166-171
15283452-5	2004	TRPV1 and ANKTM1 are mediating the pungency of nociceptor-specific chemicals such as capsaicin or mustard oil.	Capsaicin	85-94	transient receptor potential cation channel subfamily A member 1	Homo sapiens	10-16
15469041-1	2004	The capsaicin receptor TRPV1 (also known as the vanilloid receptor VR1) is a non-selective cation channel and is activated not only by capsaicin but also by noxious heat or protons.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
15469041-1	2004	The capsaicin receptor TRPV1 (also known as the vanilloid receptor VR1) is a non-selective cation channel and is activated not only by capsaicin but also by noxious heat or protons.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	67-70
15469041-4	2004	In cells expressing TRPV1, ATP increased the currents evoked by capsaicin or protons through activation of P2Y metabotropic receptors in a PKC-dependent manner.	Capsaicin	64-73	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-25
15469041-8	2004	Extracellular Ca2+ -dependent desensitization of TRPV1 is thought to be one mechanism underlying the paradoxical effectiveness of capsaicin as an analgesic therapy.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	49-54
14715385-6	2004	In vitro superfusion of isolated rat buccal mucosa with the non-selective mAChR agonist muscarine or arecaidine led to a concentration-dependent inhibition of capsaicin-evoked CGRP release to 39% (EC50=255 nM) and 28% (EC50=847 nM) of control values, respectively.	Capsaicin	159-168	calcitonin-related polypeptide alpha	Rattus norvegicus	176-180
14506258-0	2003	Desensitization of capsaicin-activated currents in the vanilloid receptor TRPV1 is decreased by the cyclic AMP-dependent protein kinase pathway.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
15099684-0	2004	Neuropeptide Y inhibits capsaicin-sensitive nociceptors via a Y1-receptor-mediated mechanism.	Capsaicin	24-33	neuropeptide Y	Rattus norvegicus	0-14
15099684-3	2004	In this study, we evaluated the hypothesis that agonists at the NPY Y1 receptor subtype (Y1-R) inhibit exocytosis from the capsaicin-sensitive class of nociceptors.	Capsaicin	123-132	neuropeptide Y	Rattus norvegicus	64-67
15099684-4	2004	Using in vitro superfusion of rat dorsal spinal cord slices, pre-treatment with the Y1-R agonist [Leu(31)Pro(34)]NPY significantly inhibited capsaicin-evoked release of immunoreactive calcitonin gene-related peptide with an EC(50) value of 10.6 nM.	Capsaicin	141-150	neuropeptide Y	Rattus norvegicus	113-116
15099684-7	2004	Collectively, these results indicate that NPY is capable of inhibiting capsaicin-sensitive neurons via a Y1 receptor mechanism, suggesting the mechanisms for spinal NPY-induced antinociception is due, at least in part, to inhibition of central terminals of capsaicin-sensitive nociceptors.	Capsaicin	71-80	neuropeptide Y	Rattus norvegicus	42-45
15099684-7	2004	Collectively, these results indicate that NPY is capable of inhibiting capsaicin-sensitive neurons via a Y1 receptor mechanism, suggesting the mechanisms for spinal NPY-induced antinociception is due, at least in part, to inhibition of central terminals of capsaicin-sensitive nociceptors.	Capsaicin	71-80	neuropeptide Y	Rattus norvegicus	165-168
15099684-7	2004	Collectively, these results indicate that NPY is capable of inhibiting capsaicin-sensitive neurons via a Y1 receptor mechanism, suggesting the mechanisms for spinal NPY-induced antinociception is due, at least in part, to inhibition of central terminals of capsaicin-sensitive nociceptors.	Capsaicin	257-266	neuropeptide Y	Rattus norvegicus	42-45
15099684-7	2004	Collectively, these results indicate that NPY is capable of inhibiting capsaicin-sensitive neurons via a Y1 receptor mechanism, suggesting the mechanisms for spinal NPY-induced antinociception is due, at least in part, to inhibition of central terminals of capsaicin-sensitive nociceptors.	Capsaicin	257-266	neuropeptide Y	Rattus norvegicus	165-168
14643332-1	2003	A novel non-vanilloid VR1 antagonist consisting of a new vanilloid equivalent exhibits excellent analgesic effects as well as highly potent antagonistic activities in both capsaicin single channel and calcium uptake assays.	Capsaicin	12-21	vault RNA 1-1	Homo sapiens	22-25
14643332-1	2003	A novel non-vanilloid VR1 antagonist consisting of a new vanilloid equivalent exhibits excellent analgesic effects as well as highly potent antagonistic activities in both capsaicin single channel and calcium uptake assays.	Capsaicin	172-181	vault RNA 1-1	Homo sapiens	22-25
14643332-2	2003	In addition, the structural requirement for the vanilloid equivalent of the potent VR1 antagonist has also been elucidated.	Capsaicin	48-57	vault RNA 1-1	Homo sapiens	83-86
12893632-6	2003	CPZ, the functional denervation of capsaicin-sensitive sensory neurons, and CGRP-(8-37) significantly increased gastric MPO activity and exacerbated the WIR-induced gastric mucosal injury in rats subjected to 4-h WIR.	Capsaicin	35-44	myeloperoxidase	Rattus norvegicus	120-123
14625038-3	2003	Labeled neurons in lamina I and III/IV were patch clamped and the vanilloid receptor 1 (TRPV1) agonist, capsaicin, was applied to evoke glutamate release from central terminals of peripheral nociceptors.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-86
14625038-3	2003	Labeled neurons in lamina I and III/IV were patch clamped and the vanilloid receptor 1 (TRPV1) agonist, capsaicin, was applied to evoke glutamate release from central terminals of peripheral nociceptors.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	88-93
14625038-4	2003	Capsaicin induced an increase in the frequency of miniature excitatory postsynaptic currents in 73% of lamina I and 43% of lamina III/IV neurons expressing NK1-receptor indicating that these neurons receive direct input from capsaicin and heat sensitive nociceptors.	Capsaicin	0-9	tachykinin receptor 1	Rattus norvegicus	156-168
12893632-7	2003	The administration of capsaicin and CGRP significantly increased the gastric tissue levels of prostaglandins and inhibited both the WIR-induced increases in gastric MPO activity and gastric mucosal injury 8 h after WIR.	Capsaicin	22-31	myeloperoxidase	Rattus norvegicus	165-168
12893632-9	2003	These observations strongly suggest that capsaicin-sensitive sensory neurons might release CGRP, thereby increasing the gastric tissue levels of PGI2 and PGE2 by activating COX-1 through activation of the constitutive form of NOS in rats subjected to WIR.	Capsaicin	41-50	calcitonin-related polypeptide alpha	Rattus norvegicus	91-95
12946940-2	2003	Nodose neurons were classified as A or C type on the basis of the characteristics of the Na+ current, a hyperpolarization-activated current, and sensitivity to a low concentration of capsaicin to ascertain the presence of vanilloid receptor 1 that has been associated with C-type neurons in sensory ganglia.	Capsaicin	183-192	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	222-242
12893632-9	2003	These observations strongly suggest that capsaicin-sensitive sensory neurons might release CGRP, thereby increasing the gastric tissue levels of PGI2 and PGE2 by activating COX-1 through activation of the constitutive form of NOS in rats subjected to WIR.	Capsaicin	41-50	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	173-178
12946940-3	2003	It was expected that only capsaicin-sensitive C-type neurons would respond to CCK, because most vagally mediated actions of CCK are blocked by capsaicin treatment.	Capsaicin	26-35	cholecystokinin	Rattus norvegicus	78-81
15075453-5	2003	The release of secretin by SRP was abolished in rats treated with TTX, mucosal or perivagal application of capsaicin, MEK or vagotomy.	Capsaicin	107-116	secretin	Rattus norvegicus	15-23
12946940-3	2003	It was expected that only capsaicin-sensitive C-type neurons would respond to CCK, because most vagally mediated actions of CCK are blocked by capsaicin treatment.	Capsaicin	26-35	cholecystokinin	Rattus norvegicus	124-127
12946940-3	2003	It was expected that only capsaicin-sensitive C-type neurons would respond to CCK, because most vagally mediated actions of CCK are blocked by capsaicin treatment.	Capsaicin	143-152	cholecystokinin	Rattus norvegicus	78-81
12946940-3	2003	It was expected that only capsaicin-sensitive C-type neurons would respond to CCK, because most vagally mediated actions of CCK are blocked by capsaicin treatment.	Capsaicin	143-152	cholecystokinin	Rattus norvegicus	124-127
12946940-5	2003	Thus some vagally mediated actions of CCK may be mediated by capsaicin insensitive A-type neurons.	Capsaicin	61-70	cholecystokinin	Rattus norvegicus	38-41
14646185-5	2003	Curcumin, carnosol, and capsaicin also inhibited the activation of AhR in this assay, although to a lesser degree.	Capsaicin	24-33	aryl hydrocarbon receptor	Homo sapiens	67-70
15075453-7	2003	Stimulation of PES and inhibition of gastric acid secretion and motility by secretin in a physiological dose are also dependent on the vagal afferent pathway as these effects of secretin are abolished by perivagal capsaicin treatment or vagotomy.	Capsaicin	214-223	secretin	Rattus norvegicus	76-84
15075453-7	2003	Stimulation of PES and inhibition of gastric acid secretion and motility by secretin in a physiological dose are also dependent on the vagal afferent pathway as these effects of secretin are abolished by perivagal capsaicin treatment or vagotomy.	Capsaicin	214-223	secretin	Rattus norvegicus	178-186
12738685-7	2003	LPS (4 mg/kg, intraperitoneal) raised significantly PPT-I mRNA level after 4 h in nodose ganglia and 12 h in the lung, and this elevation sustained for 5 d. Also, LPS caused significant increases in NEP mRNA, SP and CGRP levels, airway reactivity to capsaicin and SP, and neutrophil counts, but a significant decrease in macrophage count.	Capsaicin	250-259	membrane metallo-endopeptidase	Rattus norvegicus	199-202
14599722-10	2003	On the other hand, perivagal capsaicin prevented the protective effects of both CCK-8s and leptin on colitis.	Capsaicin	29-38	cholecystokinin	Rattus norvegicus	80-83
14599722-10	2003	On the other hand, perivagal capsaicin prevented the protective effects of both CCK-8s and leptin on colitis.	Capsaicin	29-38	leptin	Rattus norvegicus	91-97
14599722-11	2003	Our results indicate that leptin and CCK have anti-inflammatory effects on acetic acid-induced colitis in rats, which appear to be mediated by capsaicin-sensitive vagal afferent fibers involving the reduction in colonic neutrophil infiltration.	Capsaicin	143-152	leptin	Rattus norvegicus	26-32
14599722-11	2003	Our results indicate that leptin and CCK have anti-inflammatory effects on acetic acid-induced colitis in rats, which appear to be mediated by capsaicin-sensitive vagal afferent fibers involving the reduction in colonic neutrophil infiltration.	Capsaicin	143-152	cholecystokinin	Rattus norvegicus	37-40
14602831-4	2003	The VR1 agonist capsaicin at concentrations that are selective for VR1 did not affect cell viability per se or the extent of neurodegeneration induced by the OGD insult.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-7
14602831-4	2003	The VR1 agonist capsaicin at concentrations that are selective for VR1 did not affect cell viability per se or the extent of neurodegeneration induced by the OGD insult.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	67-70
14530214-0	2003	Signal transduction for inhibition of inducible nitric oxide synthase and cyclooxygenase-2 induction by capsaicin and related analogs in macrophages.	Capsaicin	104-113	prostaglandin-endoperoxide synthase 2	Homo sapiens	74-90
14530214-3	2003	In this study, the effects and action mechanisms of vanilloid analogs on iNOS and COX-2 expression were investigated in RAW264.7 macrophages.	Capsaicin	52-61	nitric oxide synthase 2	Homo sapiens	73-77
14530214-3	2003	In this study, the effects and action mechanisms of vanilloid analogs on iNOS and COX-2 expression were investigated in RAW264.7 macrophages.	Capsaicin	52-61	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	82-87
14581201-0	2003	Thermodynamics of heat activation of single capsaicin ion channels VR1.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-70
14530214-5	2003	Capsaicin and resiniferatoxin (RTX) can inhibit LPS- and IFN-gamma-mediated NO production, and iNOS protein and mRNA expression with similar IC50 values of around 10 microm.	Capsaicin	0-9	interferon gamma	Homo sapiens	57-66
14585802-3	2003	Pretreatment of immunized mice with capsaicin partially prevented the recruitment of eosinophils after antigen challenge, suggesting the potential contribution of sensory nerves for the recruitment of eosinophils Local (10-50 nmol per pleural cavity) or systemic (100-300 nmol per animal) pretreatment with the tachykinin NK1 receptor antagonist SR140333 prevented the recruitment of eosinophils induced by antigen challenge of immunized mice.	Capsaicin	36-45	tachykinin receptor 1	Mus musculus	322-334
14530214-7	2003	Capsaicin also transcriptionally inhibited LPS- and PMA-induced COX-2 expression and PGE2 production.	Capsaicin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	64-69
14622152-3	2003	The purpose of the present studies was to determine the effects of nicotine and other nAChR agonists on capsaicin-evoked immunoreactive CGRP (iCGRP) release from rat buccal mucosa and to identify a potential cellular basis for these effects.	Capsaicin	104-113	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	86-91
14622152-3	2003	The purpose of the present studies was to determine the effects of nicotine and other nAChR agonists on capsaicin-evoked immunoreactive CGRP (iCGRP) release from rat buccal mucosa and to identify a potential cellular basis for these effects.	Capsaicin	104-113	calcitonin-related polypeptide alpha	Rattus norvegicus	136-140
14622152-4	2003	Using a previously validated model of in vitro superfusion, we show that the nAChR agonists nicotine (EC50 557 micro m), epibatidine (EC50 317 pm) and cytisine (EC50 4.83 nm) potentiated capsaicin-evoked iCGRP release in a concentration-dependent manner by 123, 70 and 76%, respectively.	Capsaicin	187-196	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	77-82
12926020-7	2003	The vanilloid receptor (VR1) is a nonselective cation channel that is activated by capsaicin, acid, and temperature.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-27
12949222-5	2003	This capsaicin-induced vasodilatation was abolished by capsazepine, a transient receptor potential vanilloid 1 (TRPV1) receptor antagonist, and by hCGRP8-37, a calcitonin gene-related peptide (CGRP) receptor antagonist.	Capsaicin	5-14	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	70-110
12949222-5	2003	This capsaicin-induced vasodilatation was abolished by capsazepine, a transient receptor potential vanilloid 1 (TRPV1) receptor antagonist, and by hCGRP8-37, a calcitonin gene-related peptide (CGRP) receptor antagonist.	Capsaicin	5-14	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-117
12949222-5	2003	This capsaicin-induced vasodilatation was abolished by capsazepine, a transient receptor potential vanilloid 1 (TRPV1) receptor antagonist, and by hCGRP8-37, a calcitonin gene-related peptide (CGRP) receptor antagonist.	Capsaicin	5-14	calcitonin-related polypeptide alpha	Rattus norvegicus	160-191
12949222-5	2003	This capsaicin-induced vasodilatation was abolished by capsazepine, a transient receptor potential vanilloid 1 (TRPV1) receptor antagonist, and by hCGRP8-37, a calcitonin gene-related peptide (CGRP) receptor antagonist.	Capsaicin	5-14	calcitonin-related polypeptide alpha	Rattus norvegicus	148-152
12949222-9	2003	The results indicate that capsaicin-induced vasodilatation in the rat dura mater is mediated by the release of CGRP from the sensory nerves, whereas the vasoconstrictor response may be attributed to a direct action of capsaicin on the vascular smooth muscle.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	111-115
14559367-1	2003	The present project was designed to investigate the role of protein kinase A (PKA) and protein kinase C (PKC) in the regulation of phosphorylation of the GluR1 subunits of AMPA receptors in the spinal cord of rats after capsaicin injection.	Capsaicin	220-229	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	60-76
14559367-1	2003	The present project was designed to investigate the role of protein kinase A (PKA) and protein kinase C (PKC) in the regulation of phosphorylation of the GluR1 subunits of AMPA receptors in the spinal cord of rats after capsaicin injection.	Capsaicin	220-229	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	154-159
14559367-2	2003	We found that after capsaicin injection, a significant upregulation of phosphorylated GluR1 both at Ser(831) and Ser(845) was detected on the side ipsilateral to the injection.	Capsaicin	20-29	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	86-91
12974907-8	2003	Furthermore, this study was verified using lafutidine, a histamine H2-receptor antagonist, which has a gastric mucosal protective action through the capsaicin-sensitive afferent nerves.	Capsaicin	149-158	histamine receptor H 2	Rattus norvegicus	57-78
12801885-1	2003	Recent studies demonstrated that cholecystokinin (CCK) at physiological levels stimulates pancreatic enzyme secretion via a capsaicin-sensitive afferent vagal pathway.	Capsaicin	124-133	cholecystokinin	Rattus norvegicus	50-53
12801885-5	2003	Perivagal application of capsaicin increased plasma CCK levels and significantly increased pancreatic wet weight compared with those in the control rats.	Capsaicin	25-34	cholecystokinin	Rattus norvegicus	52-55
12801885-6	2003	Oral administration of CCK-1 receptor antagonist loxiglumide prevented the increase in pancreatic wet weight after capsaicin treatment.	Capsaicin	115-124	cholecystokinin	Rattus norvegicus	23-26
12801885-7	2003	In addition, continuous intraduodenal infusion of trypsin prevented the increase in plasma CCK levels and pancreatic wet weight after capsaicin treatment.	Capsaicin	134-143	cholecystokinin	Rattus norvegicus	91-94
12801885-10	2003	In contrast, repeated oral administrations of camostat or intraperitoneal injections of CCK-8 significantly increased pancreatic wet weight in both capsaicin-treated and control rats.	Capsaicin	148-157	cholecystokinin	Rattus norvegicus	88-91
12801885-11	2003	Present results suggest that perivagal application of capsaicin stimulates pancreatic growth via an increase in endogenous CCK and that exogenous and endogenous CCK stimulate pancreatic growth not via vagal afferent fibers but directly in rats.	Capsaicin	54-63	cholecystokinin	Rattus norvegicus	123-126
14534154-0	2003	Vanilloid type 1 receptors (VR1) on trigeminal sensory nerve fibres play a minor role in neurogenic dural vasodilatation, and are involved in capsaicin-induced dural dilation.	Capsaicin	142-151	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-31
14534154-1	2003	Capsaicin, the active substance in chilli peppers, activates the vanilloid type 1 receptor (VR1) rather than the vanilloid-like receptor (VRL1) in the trigeminal ganglion and nucleus of small and medium C- and Adelta-fibres.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-95
14534154-2	2003	Capsaicin induces calcitonin gene-related peptide (CGRP) release when VR1 receptors are activated, and this can be reversed by both the VR1 receptor antagonist capsazepine and the CGRP blocker alphaCGRP8-37 in vitro.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	18-49
14534154-2	2003	Capsaicin induces calcitonin gene-related peptide (CGRP) release when VR1 receptors are activated, and this can be reversed by both the VR1 receptor antagonist capsazepine and the CGRP blocker alphaCGRP8-37 in vitro.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	51-55
14534154-2	2003	Capsaicin induces calcitonin gene-related peptide (CGRP) release when VR1 receptors are activated, and this can be reversed by both the VR1 receptor antagonist capsazepine and the CGRP blocker alphaCGRP8-37 in vitro.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-73
14534154-2	2003	Capsaicin induces calcitonin gene-related peptide (CGRP) release when VR1 receptors are activated, and this can be reversed by both the VR1 receptor antagonist capsazepine and the CGRP blocker alphaCGRP8-37 in vitro.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	136-139
14534154-2	2003	Capsaicin induces calcitonin gene-related peptide (CGRP) release when VR1 receptors are activated, and this can be reversed by both the VR1 receptor antagonist capsazepine and the CGRP blocker alphaCGRP8-37 in vitro.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	180-184
14534154-5	2003	We also looked at the effect of the CGRP blocker alphaCGRP8-37 (300 microg x kg-1) on capsaicin-induced dilation so that we could see if the results found in vitro could also be found in vivo.	Capsaicin	86-95	calcitonin related polypeptide alpha	Homo sapiens	36-40
14534154-10	2003	AlphaCGRP8-37 also inhibited the capsaicin-induced dilation (t5=7.4, P<0.05) probably inhibiting the action of released CGRP at the CGRP receptor.	Capsaicin	33-42	calcitonin related polypeptide alpha	Homo sapiens	5-9
14534154-10	2003	AlphaCGRP8-37 also inhibited the capsaicin-induced dilation (t5=7.4, P<0.05) probably inhibiting the action of released CGRP at the CGRP receptor.	Capsaicin	33-42	calcitonin related polypeptide alpha	Homo sapiens	123-127
14534154-11	2003	The study demonstrates that capsaicin can repeatedly induce dural vessel dilation in vivo, presumably through inducing CGRP release from trigeminal sensory nerve fibres, while C-fibres may have been desensitised.	Capsaicin	28-37	calcitonin related polypeptide alpha	Homo sapiens	119-123
14575802-0	2003	Involvement of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic cytoprotection.	Capsaicin	51-60	thyrotropin releasing hormone	Homo sapiens	92-121
14575802-2	2003	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the protective effect of intracisternal TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 5 ng) against carbon tetrachloride (CCl4)-induced acute liver injury, assessed by serum alanin aminotransferase levels and histological changes.	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	71-75
14575802-2	2003	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the protective effect of intracisternal TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 5 ng) against carbon tetrachloride (CCl4)-induced acute liver injury, assessed by serum alanin aminotransferase levels and histological changes.	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	103-107
12801885-1	2003	Recent studies demonstrated that cholecystokinin (CCK) at physiological levels stimulates pancreatic enzyme secretion via a capsaicin-sensitive afferent vagal pathway.	Capsaicin	124-133	cholecystokinin	Rattus norvegicus	33-48
12815018-11	2003	Pretreatment with the VR1 receptor antagonist, capsazepine (10 nmol in 0.4 microl), into the dPAG blocked the capsaicin-induced hyperalgesia as well as the corresponding changes in on- and off-cell activity.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-25
14564346-0	2003	Elevated substance P levels in nasal lavage fluids from patients with chronic nonproductive cough and increased cough sensitivity to inhaled capsaicin.	Capsaicin	141-150	tachykinin precursor 1	Homo sapiens	9-20
14527709-9	2003	Neonatal capsaicin pre-treatment inhibited NGF- and TNBS-induced decrease in colonic pain threshold: 49.4 +/- 5.3 versus 22.3 +/- 1.6 mmHg (p<0.01) for capsaicin versus vehicle in NGF-treated rats and 39.6 +/- 3.3 versus 18.0 +/- 1.0 mm Hg (p<0.001) for capsaicin versus vehicle in TNBS-treated rats.	Capsaicin	9-18	nerve growth factor	Rattus norvegicus	43-46
14508237-0	2003	A novel capsaicin derivative VOA induced relaxation in rat mesenteric and aortic arteries: involvement of CGRP, NO, cGMP, and endothelium-dependent activities.	Capsaicin	8-17	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
14527709-9	2003	Neonatal capsaicin pre-treatment inhibited NGF- and TNBS-induced decrease in colonic pain threshold: 49.4 +/- 5.3 versus 22.3 +/- 1.6 mmHg (p<0.01) for capsaicin versus vehicle in NGF-treated rats and 39.6 +/- 3.3 versus 18.0 +/- 1.0 mm Hg (p<0.001) for capsaicin versus vehicle in TNBS-treated rats.	Capsaicin	9-18	nerve growth factor	Rattus norvegicus	183-186
14527709-9	2003	Neonatal capsaicin pre-treatment inhibited NGF- and TNBS-induced decrease in colonic pain threshold: 49.4 +/- 5.3 versus 22.3 +/- 1.6 mmHg (p<0.01) for capsaicin versus vehicle in NGF-treated rats and 39.6 +/- 3.3 versus 18.0 +/- 1.0 mm Hg (p<0.001) for capsaicin versus vehicle in TNBS-treated rats.	Capsaicin	155-164	nerve growth factor	Rattus norvegicus	43-46
14555187-22	2003	Contractions to capsaicin (30 nM and 1 microM) were resistant to tetrodotoxin, strongly reduced by a combination of tachykinin NK(1) and NK(2) receptor antagonists, and slightly reduced in preparations from diabetic animals.	Capsaicin	16-25	tachykinin receptor 2	Rattus norvegicus	137-151
14527709-9	2003	Neonatal capsaicin pre-treatment inhibited NGF- and TNBS-induced decrease in colonic pain threshold: 49.4 +/- 5.3 versus 22.3 +/- 1.6 mmHg (p<0.01) for capsaicin versus vehicle in NGF-treated rats and 39.6 +/- 3.3 versus 18.0 +/- 1.0 mm Hg (p<0.001) for capsaicin versus vehicle in TNBS-treated rats.	Capsaicin	155-164	nerve growth factor	Rattus norvegicus	43-46
14554100-2	2003	It has been previously shown that PMs and synthetic particles (PC10 and PC2) that have similar characteristics to PMs induced depolarizing currents and increases in intracellular calcium ([Ca2+]i) in capsaicin- and acid-sensitive sensory neurons and in TRPV1-expressing HEK 293 cells.	Capsaicin	200-209	keratin 6B	Homo sapiens	72-75
12909686-5	2003	The sensitivity of the bronchopulmonary C-fibres to the vanilloid receptor 1 (VR1) agonist capsaicin was dependent on conduction velocity.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	56-76
12946582-1	2003	The vanilloid receptor VR1 renders a group of primary afferents that express it sensitive to noxious heat and capsaicin, and is thus an important marker for nociceptors.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	23-26
12909686-5	2003	The sensitivity of the bronchopulmonary C-fibres to the vanilloid receptor 1 (VR1) agonist capsaicin was dependent on conduction velocity.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-81
12829722-11	2003	Furthermore, epicardial application of iodo-RTX, a highly specific antagonist of VR1 receptors, blocked capsaicin- but not bradykinin-induced sympathoexcitatory responses.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	81-84
12963499-1	2003	Vanilloid receptors subtype 1 (VR1), a nonselective cation channel responsive to capsaicin, protons, and noxious heat, has been recently identified in not only neural but also non-neural cells.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-34
14614531-3	2003	Pretreatment of mice with neurokinin-1 and calcitonin-gene-related peptide (CGRP) receptor antagonists or with capsaicin showed attenuated PAR2-agonist-induced colitis.	Capsaicin	111-120	coagulation factor II (thrombin) receptor-like 1	Mus musculus	139-143
12967999-5	2003	Capsaicin-evoked calcitonin gene-related peptide (CGRP) release was markedly enhanced in lumbar spinal tissue from SNL rats when compared with sham-operated controls.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	17-48
12967999-5	2003	Capsaicin-evoked calcitonin gene-related peptide (CGRP) release was markedly enhanced in lumbar spinal tissue from SNL rats when compared with sham-operated controls.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	50-54
12948856-5	2003	This compound inhibited capsaicin-induced Ca(2+) influx into rVR1-HEK293 cells with a pK(B) value of 6.8+/-0.3.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-65
12970078-2	2003	Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive trigeminal sensory nerves, seems to be involved in the pathogenesis of migraine.	Capsaicin	75-84	Calcitonin gene-related peptide	Sus scrofa	0-31
12970078-2	2003	Calcitonin gene-related peptide (CGRP), a potent vasodilator released from capsaicin-sensitive trigeminal sensory nerves, seems to be involved in the pathogenesis of migraine.	Capsaicin	75-84	Calcitonin gene-related peptide	Sus scrofa	33-37
12970078-5	2003	), a potent and selective CGRP receptor antagonist, on capsaicin-induced carotid haemodynamic changes in anaesthetised pigs.	Capsaicin	55-64	Calcitonin gene-related peptide	Sus scrofa	26-30
12970078-21	2003	The above results show that BIBN4096BS behaves as a potent antagonist of capsaicin-induced carotid haemodynamic changes that are mediated via the release of CGRP.	Capsaicin	73-82	Calcitonin gene-related peptide	Sus scrofa	157-161
12970093-7	2003	These effects of capsaicin were mimicked by calcitonin gene-related peptide (CGRP; 1 and 10 nm) but not by substance P (50 nm), which produced a small hyperpolarization (maximum -3+/-1 mV) but did not change excitatory junction potential (e.j.p.)	Capsaicin	17-26	calcitonin-related polypeptide alpha	Rattus norvegicus	44-75
12970093-7	2003	These effects of capsaicin were mimicked by calcitonin gene-related peptide (CGRP; 1 and 10 nm) but not by substance P (50 nm), which produced a small hyperpolarization (maximum -3+/-1 mV) but did not change excitatory junction potential (e.j.p.)	Capsaicin	17-26	calcitonin-related polypeptide alpha	Rattus norvegicus	77-81
12912853-2	2003	Administration of capsaicin also inhibited ethanol induced gastric mucosal injury through immediate release of CGRP from primary sensory neurones, which is termed the neural emergency system.	Capsaicin	18-27	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	111-115
12912853-9	2003	Fifty per cent ethanol containing capsaicin (480 micro M) immediately increased intragastric levels of CGRP although 50% ethanol alone did not.	Capsaicin	34-43	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	103-107
12912853-10	2003	The protective action of capsaicin (480 micro M) against ethanol was completely abolished by intravenous injection of CGRP-(8-37).	Capsaicin	25-34	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	118-122
12912853-11	2003	Indomethacin also inhibited the protective action of capsaicin, and this was accompanied by reduced levels of intragastric CGRP.	Capsaicin	53-62	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	123-127
12912853-17	2003	CONCLUSIONS: The present results suggest that endogenous prostaglandin I(2) enhances the protective action of the capsaicin mediated neural emergency system against ethanol induced gastric mucosal injury through enhancement of CGRP release.	Capsaicin	114-123	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	227-231
14504662-9	2003	Sensory deactivation with capsaicin enhanced acute ethanol lesions and led to a significant attenuation in HSP70 expression.	Capsaicin	26-35	heat shock protein family A (Hsp70) member 1B	Rattus norvegicus	107-112
12815188-2	2003	We have developed a new technique to study this rapid sensitisation of TRPV1 by monitoring the effects of NGF on the increase in intracellular calcium concentration ([Ca2+]i) following exposure to capsaicin.	Capsaicin	197-206	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	71-76
14501156-4	2003	Ovariectomy attenuated the capsaicin-evoked increase in plasma concentration of CGRP, which was restored by treatment with 17beta-estradiol (0.010 mg/kg, s.c.) or Keishi-bukuryo-gan (1000 mg/kg, p.o.)	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
14550768-1	2003	Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-39
14550768-7	2003	These results imply that capsaicin induces mitochondrial dysfunction in VR1-expressing cells, leading to apoptotic cell death, which is a well-known neurotoxic effect of capsaicin.	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-75
14550768-1	2003	Capsaicin causes pain by activating VR1, a cloned capsaicin receptor, in sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-68
14550768-4	2003	Here we report that capsaicin induces cell death in VR1-expressing sensory neurons and VR1-transfected human embryonic kidney cells.	Capsaicin	20-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-55
14550768-4	2003	Here we report that capsaicin induces cell death in VR1-expressing sensory neurons and VR1-transfected human embryonic kidney cells.	Capsaicin	20-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-90
14550768-7	2003	These results imply that capsaicin induces mitochondrial dysfunction in VR1-expressing cells, leading to apoptotic cell death, which is a well-known neurotoxic effect of capsaicin.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-75
12886029-1	2003	The vanilloid receptor 1 (VR1) is a heat-activated cation channel which also responds to capsaicin and other chemical stimuli.	Capsaicin	89-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-29
14499433-2	2003	Capsaicin activates vanilloid receptor 1, a multi-functional receptor for pain sensation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-40
12886029-2	2003	Protein kinase C has a stimulatory effect on VR1 activity, either alone or after activation with capsaicin.	Capsaicin	97-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-48
12886029-5	2003	Capsaicin activated the VR1 channel and increased the intracellular calcium concentration.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-27
12941468-2	2003	Instillation of either capsaicin or mustard oil induced a significant activation of lumbosacral spinal ERK1/2, measured by immunoblot, with a peak 2.4-fold increase over control levels between 45 and 90 min post-treatment.	Capsaicin	23-32	mitogen-activated protein kinase 3	Mus musculus	103-109
12913761-8	2003	After capsaicin instillation the micturition interval and volume decreased, and micturition pressure increased in WT, ERbeta and 2 gene mice, while no changes were seen in ERKO mice.	Capsaicin	6-15	estrogen receptor 2 (beta)	Mus musculus	118-130
12941468-5	2003	Both mustard oil and capsaicin produced a redistribution of phosphorylated ERK1/2 from cytosol into the nucleus that was statistically significant at 45 min after treatment.	Capsaicin	21-30	mitogen-activated protein kinase 3	Mus musculus	75-81
12941468-6	2003	Spinal ERK1/2 activation with capsaicin treatment correlated with the development of prolonged referred hyperalgesia.	Capsaicin	30-39	mitogen-activated protein kinase 3	Mus musculus	7-13
12941468-7	2003	The upstream inhibitor of ERK phosphorylation, U0126 (100-400 microg/kg, i.v., 10 min pre-capsaicin), dose-dependently inhibited referred hyperalgesia 3-6 h after capsaicin.	Capsaicin	90-99	mitogen-activated protein kinase 1	Mus musculus	26-29
12941468-7	2003	The upstream inhibitor of ERK phosphorylation, U0126 (100-400 microg/kg, i.v., 10 min pre-capsaicin), dose-dependently inhibited referred hyperalgesia 3-6 h after capsaicin.	Capsaicin	163-172	mitogen-activated protein kinase 1	Mus musculus	26-29
12724350-0	2003	Increased expression of vanilloid receptor 1 on myelinated primary afferent neurons contributes to the antihyperalgesic effect of capsaicin cream in diabetic neuropathic pain in mice.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	24-44
12922928-0	2003	Halogenation of a capsaicin analogue leads to novel vanilloid TRPV1 receptor antagonists.	Capsaicin	18-27	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-67
12922928-3	2003	Here, we have synthesized a series of halogenated derivatives of "synthetic capsaicin" (nonanoyl vanillamide=nordihydrocapsaicin) differing for the nature (iodine, bromine-chlorine) and the regiochemistry (C-5, C-6) of the halogenation.	Capsaicin	76-85	complement C5	Homo sapiens	206-209
12922928-3	2003	Here, we have synthesized a series of halogenated derivatives of "synthetic capsaicin" (nonanoyl vanillamide=nordihydrocapsaicin) differing for the nature (iodine, bromine-chlorine) and the regiochemistry (C-5, C-6) of the halogenation.	Capsaicin	76-85	complement C6	Homo sapiens	211-214
12922928-12	2003	Using human recombinant TRPV1, 6-iodo-nordihydrocapsaicin (IC(50)=10 nM against 100 nM capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine, and was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
12922928-12	2003	Using human recombinant TRPV1, 6-iodo-nordihydrocapsaicin (IC(50)=10 nM against 100 nM capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine, and was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-158
12922928-12	2003	Using human recombinant TRPV1, 6-iodo-nordihydrocapsaicin (IC(50)=10 nM against 100 nM capsaicin) was about four times more potent than the prototypical TRPV1 antagonist, capsazepine, and was tested against capsaicin also on native TRPV1 in: (i) rat dorsal root ganglion neurons in culture; (ii) guinea-pig urinary bladder; and (iii) guinea-pig bronchi.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-158
12724350-1	2003	Topical capsaicin is believed to alleviate pain by desensitizing the vanilloid receptor 1 (VR1) at the peripheral nerve endings.	Capsaicin	8-17	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	69-89
12724350-1	2003	Topical capsaicin is believed to alleviate pain by desensitizing the vanilloid receptor 1 (VR1) at the peripheral nerve endings.	Capsaicin	8-17	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	91-94
12724350-2	2003	Here, we report that an up-regulation of VR1 expression on myelinated fibers contributes to the antihyperalgesic effect of capsaicin cream in streptozotocin (STZ)-induced diabetic neuropathic pain.	Capsaicin	123-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	41-44
12724350-14	2003	capsaicin-induced biting-licking responses were blocked by the competitive VR1 antagonist capsazepine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	75-78
12939520-5	2003	Treatment with lafutidine (a new type of antagonist of the histamine H(2) receptor), which was suggested to interact with capsaicin-sensitive neurons in vivo, also showed both stimulatory and inhibitory effects on capsaicin-induced contraction depending on the concentrations.	Capsaicin	122-131	histamine H2 receptor	Cavia porcellus	59-82
12724350-17	2003	Together, our results suggest that increased expression of VR1 on myelinated fibers might contribute to the antihyperalgesic effect of topical capsaicin in diabetic neuropathic pain.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	59-62
12939520-5	2003	Treatment with lafutidine (a new type of antagonist of the histamine H(2) receptor), which was suggested to interact with capsaicin-sensitive neurons in vivo, also showed both stimulatory and inhibitory effects on capsaicin-induced contraction depending on the concentrations.	Capsaicin	214-223	histamine H2 receptor	Cavia porcellus	59-82
12832107-8	2003	Treatment with capsaicin, a single injection or a second injection, prevented the increased in the expression of CGRP mRNA in DRG.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	113-117
12834907-0	2003	Electroacupuncture induces the expression of Fos in rat dorsal horn via capsaicin-insensitive afferents.	Capsaicin	72-81	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	45-48
12834907-4	2003	Fos expression in the dorsal horn after injection of formalin into the hindpaw was severely attenuated by neonatal capsaicin treatment.	Capsaicin	115-124	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
12834907-6	2003	These results suggest that E-acupuncture induces the expression of Fos in the dorsal horn neurons via capsaicin-insensitive afferents, presumably Adelta afferents.	Capsaicin	102-111	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-70
12869637-1	2003	The vanilloid receptor VR1 is a polymodal nociceptor sensitive to capsaicin, protons, and heat.	Capsaicin	66-75	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	23-26
12906841-5	2003	These results suggests that vanilloid receptor 1 on capsaicin-sensitive sensory nerves plays an important role in the modulation of the delayed cardioprotection induced by heat stress in rats.	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	28-48
12832107-9	2003	However, the decreased level of CGRP was only observed in the rats treated with a second capsaicin.	Capsaicin	89-98	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
12832107-10	2003	These results suggest that in 2K1C hypertensive rats, the activity of capsaicin-sensitive sensory nerves is increased, which is playing a compensatory depressor role to partially counteract the increase in blood pressure, and that the cardiovascular actions of CGRP is mediated by the alpha-CGRP isoform.	Capsaicin	70-79	calcitonin-related polypeptide alpha	Rattus norvegicus	261-265
12832107-10	2003	These results suggest that in 2K1C hypertensive rats, the activity of capsaicin-sensitive sensory nerves is increased, which is playing a compensatory depressor role to partially counteract the increase in blood pressure, and that the cardiovascular actions of CGRP is mediated by the alpha-CGRP isoform.	Capsaicin	70-79	calcitonin-related polypeptide alpha	Rattus norvegicus	291-295
12835470-0	2003	Low pH potentiates both capsaicin binding and channel gating of VR1 receptors.	Capsaicin	24-33	vault RNA 1-1	Homo sapiens	64-67
12825950-1	2003	Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells.	Capsaicin	213-222	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-86
12825950-1	2003	Isosteric replacement of the phenolic hydroxyl group in potent vanilloid receptor (VR1) agonists with the alkylsulfonamido group provides a series of compounds which are effective antagonists to the action of the capsaicin on rat VR1 heterologously expressed in Chinese hamster ovary (CHO) cells.	Capsaicin	213-222	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	230-233
12824234-0	2003	Restoration of corneal epithelial barrier function and wound healing by substance P and IGF-1 in rats with capsaicin-induced neurotrophic keratopathy.	Capsaicin	107-116	insulin-like growth factor 1	Rattus norvegicus	88-93
12824234-1	2003	PURPOSE: To investigate the effects of topical application of the combination of substance P (SP) and insulin-like growth factor (IGF)-1 on corneal epithelial barrier function and epithelial wound closure in rats with capsaicin-induced neurotrophic keratopathy.	Capsaicin	218-227	insulin-like growth factor 1	Rattus norvegicus	102-136
12824234-8	2003	The application of eye drops containing the combination of SP and IGF-1 to capsaicin-injected rats resulted in a significant improvement in corneal epithelial barrier function compared with that apparent in capsaicin-injected animals that received eye drops containing vehicle alone.	Capsaicin	75-84	insulin-like growth factor 1	Rattus norvegicus	66-71
12824234-9	2003	Such treatment with SP and IGF-1 also significantly increased the rate of corneal epithelial wound closure in capsaicin-injected animals.	Capsaicin	110-119	insulin-like growth factor 1	Rattus norvegicus	27-32
12853424-2	2003	It has been reported that extracellular ATP potentiates the TRPV1 currents evoked by capsaicin or protons and reduces the temperature threshold for its activation through metabotropic P2Y receptors in a PKC-dependent pathway, suggesting that TRPV1 activation could trigger the sensation of pain at normal body temperature in the presence of ATP.	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-65
12853424-2	2003	It has been reported that extracellular ATP potentiates the TRPV1 currents evoked by capsaicin or protons and reduces the temperature threshold for its activation through metabotropic P2Y receptors in a PKC-dependent pathway, suggesting that TRPV1 activation could trigger the sensation of pain at normal body temperature in the presence of ATP.	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	242-247
12810854-1	2003	The biosynthesis of capsaicinoids in the placenta of chilli fruit is modelled to require components of the fatty acid synthase (FAS) complex.	Capsaicin	20-33	fatty acid synthase	Homo sapiens	107-126
12810854-1	2003	The biosynthesis of capsaicinoids in the placenta of chilli fruit is modelled to require components of the fatty acid synthase (FAS) complex.	Capsaicin	20-33	fatty acid synthase	Homo sapiens	128-131
12665541-0	2003	Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.	Capsaicin	101-110	prepronociceptin	Mus musculus	33-44
14520770-1	2003	AIMS: To investigate the levels of the capsaicin or vanilloid receptor-1 (VR1) and the ATP-gated purinoceptor P2X3 in painful and nonpainful human tooth pulps.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-77
12665541-0	2003	Nocistatin and prepro-nociceptin/orphanin FQ 160-187 cause nociception through activation of Gi/o in capsaicin-sensitive and of Gs in capsaicin-insensitive nociceptors, respectively.	Capsaicin	134-143	prepronociceptin	Mus musculus	33-44
12721336-2	2003	The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive sensory neurons and is activated by a wide array of pain-producing stimuli, including capsaicin, noxious heat, and low pH.	Capsaicin	176-185	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-24
12721336-2	2003	The vanilloid receptor 1 (VR1) is a cation channel expressed predominantly by nociceptive sensory neurons and is activated by a wide array of pain-producing stimuli, including capsaicin, noxious heat, and low pH.	Capsaicin	176-185	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-29
12721336-4	2003	N-(4-Tertiarybutylphenyl)-4-(3-cholorphyridin-2-yl)tetrahydropryazine-1(2H)-carbox-amide (BCTC) is a recently described inhibitor of capsaicin- and acid-mediated currents at rat VR1.	Capsaicin	133-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	178-181
12721338-1	2003	Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	109-129
12721338-1	2003	Vanilloids such as capsaicin have algesic properties and seem to mediate their effects via activation of the vanilloid receptor 1 (VR1), a ligand-gated ion channel highly expressed on primary nociceptors.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	131-134
12808128-2	2003	Extracellular Ca2+-dependent desensitization of TRPV1 observed in patch-clamp experiments when using both heterologous expression systems and native sensory ganglia is thought to be one mechanism underlying the paradoxical effectiveness of capsaicin as an analgesic therapy.	Capsaicin	240-249	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
12721338-2	2003	Although blockade of capsaicin-induced VR1 activation has been demonstrated in vitro and in vivo with the antagonist capsazepine, efficacy in rat models of chronic pain has not been observed with this compound.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	39-42
12721338-4	2003	Similar to capsazepine, this compound inhibits capsaicin-induced activation of rat VR1 with an IC50 value of 35 nM.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-86
12891003-4	2003	Capsaicin treatment during K(+)-induced contractions caused a persistent potentiation of the contractile response in mesenteric arteries, indicating that K(+) stimulates the endogenous release of CGRP.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	196-200
12855330-0	2003	The role of calcitonin gene-related peptide (CGRP) in the generation and maintenance of mechanical allodynia and hyperalgesia in rats after intradermal injection of capsaicin.	Capsaicin	165-174	calcitonin-related polypeptide alpha	Rattus norvegicus	45-49
12855330-1	2003	This study was designed to assess the role of calcitonin gene-related peptide (CGRP) and its receptor in the generation and maintenance of secondary mechanical allodynia and hyperalgesia induced by intradermal injection of capsaicin in rats.	Capsaicin	223-232	calcitonin-related polypeptide alpha	Rattus norvegicus	46-77
12855330-1	2003	This study was designed to assess the role of calcitonin gene-related peptide (CGRP) and its receptor in the generation and maintenance of secondary mechanical allodynia and hyperalgesia induced by intradermal injection of capsaicin in rats.	Capsaicin	223-232	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
12855330-5	2003	When CGRP(8-37) was administered 1h after capsaicin injection, the mechanical allodynia and hyperalgesia were partially reversed in a dose-dependent manner.	Capsaicin	42-51	calcitonin-related polypeptide alpha	Rattus norvegicus	5-9
12855330-6	2003	On the other hand, when rats were treated with CGRP(8-37) prior to capsaicin injection, the PWRs to von Frey applications were significantly reduced as compared to control animals.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	47-51
12855335-9	2003	Intradermal capsaicin injection also evoked Fos expression in both PSDC and STT neurons, but with no significant difference between these two, when expressed as a percentage of the retrogradely labeled cells (11.6+/-2.9% SEM, 10.8+/-1.1% SEM).	Capsaicin	12-21	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-47
12768540-5	2003	The present studies use the drug capsaicin, a neurotoxin selective for a subset of primary afferent neurons, to specifically remove CGRP-positive fibers from the adrenal gland and assess subsequent effects on the recovery of adrenal mass and function after surgical enucleation.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	132-136
12768540-9	2003	Periaxonal capsaicin treatment decreased adrenal CGRP content prior to surgical enucleation; however, reinnervation by CGRP-positive fibers was not prevented and regeneration was not affected.	Capsaicin	11-20	calcitonin-related polypeptide alpha	Rattus norvegicus	49-53
12768540-10	2003	Systemic capsaicin treatment attenuated the reinnervation by CGRP-positive fibers and increased the rate, but not extent, of adrenal regeneration.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	61-65
12832498-7	2003	Capsaicin-evoked Ca2+ transients were completely blocked by the vanilloid receptor 1 antagonist capsazepine (100 microm).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-84
15320697-1	2003	Capsaicin (8-methyl-N-vannillyl-6-nonenamide), via binding to the vanilloid receptor subtype 1 (VR1), stimulates a subpopulation of primary afferent neurons that project to cardiovascular and renal tissues.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-94
12573980-5	2003	Inhibition of nociceptin-mediated vasoconstriction revealed a supplementary hyperemic response that persisted in animals whose knee joints were treated with 1% capsaicin to destroy the articular unmyelinated nerve supply.	Capsaicin	160-169	prepronociceptin	Rattus norvegicus	14-24
12608892-2	2003	Stimulation of TRPV1-expressing cells, but not control Sf 9 cells, with resiniferatoxin (RTX), capsaicin or anandamide, produced an increase in cytosolic free Ca(2+) concentration ([Ca(2+)](i)), with EC(50) values of 166 pM, 24.5 nM and 3.89 microM respectively.	Capsaicin	95-104	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
12888332-2	2003	In this study, we investigate the role of SANs as mediators of protein catabolism and the insulin-like growth factor (IGF) axis during abdominal sepsis using capsaicin (Cap) to selectively destroy nociceptive sensory axons.	Capsaicin	158-167	insulin-like growth factor 1	Rattus norvegicus	118-121
12888332-13	2003	The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.	Capsaicin	171-180	insulin-like growth factor 1	Rattus norvegicus	39-44
12888332-13	2003	The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.	Capsaicin	171-180	insulin-like growth factor 1	Rattus norvegicus	66-71
12888332-13	2003	The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.	Capsaicin	171-180	insulin-like growth factor binding protein 1	Rattus norvegicus	120-127
12888332-13	2003	The sepsis-induced decrease in hepatic IGF-I mRNA and circulating IGF-I (26%), as well as the 4-fold increase in plasma IGFBP-1 and hepatic IGFBP-1 mRNA were prevented by capsaicin.	Capsaicin	171-180	insulin-like growth factor binding protein 1	Rattus norvegicus	140-147
12888332-14	2003	CONCLUSIONS: Capsaicin-sensitive nerves mediate mortality, the catabolism of skeletal muscle, and selected elements of the IGF system during abdominal sepsis.	Capsaicin	13-22	insulin-like growth factor 1	Rattus norvegicus	123-126
15320697-1	2003	Capsaicin (8-methyl-N-vannillyl-6-nonenamide), via binding to the vanilloid receptor subtype 1 (VR1), stimulates a subpopulation of primary afferent neurons that project to cardiovascular and renal tissues.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-99
15320697-3	2003	Regarding the latter, these neurons release stored neuropeptides through a calcium-dependent mechanism via the binding of capsaicin to the VR1.	Capsaicin	122-131	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	139-142
15320697-4	2003	A subset of capsaicin-sensitive sensory nerves contains calcitonin gene-related peptide (CGRP) and substance P (SP).	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	56-87
15320697-4	2003	A subset of capsaicin-sensitive sensory nerves contains calcitonin gene-related peptide (CGRP) and substance P (SP).	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
12823468-0	2003	Anandamide regulates neuropeptide release from capsaicin-sensitive primary sensory neurons by activating both the cannabinoid 1 receptor and the vanilloid receptor 1 in vitro.	Capsaicin	47-56	transient receptor potential cation channel subfamily V member 1	Homo sapiens	145-165
12760991-1	2003	UNLABELLED: Capsaicin, acting at the vanilloid 1 receptor (VR1), may potentiate local anesthetic activity, and as a ligand-gated ion channel of the transient receptor potential family, may also be a target for IV general anesthetics.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	59-62
12760991-9	2003	IMPLICATIONS: Vanilloid receptors (VR1) are activated by capsaicin, the pain-producing component of hot chili peppers.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-38
12823468-4	2003	In the presence of SR141716A at concentrations < 100 nm, anandamide was equipotent with capsaicin in stimulating CGRP release.	Capsaicin	91-100	calcitonin related polypeptide alpha	Homo sapiens	116-120
12823468-6	2003	Three and ten nanomolar anandamide inhibited the capsaicin-evoked CGRP release.	Capsaicin	49-58	calcitonin related polypeptide alpha	Homo sapiens	66-70
12692270-3	2003	VR-1 is a non-selective ion channel, found on sensory neurons, that primarily fluxes Ca(2+) ions in response to various stimuli, including physiologically acidic conditions, heat greater than 45 degrees C and noxious compounds such as capsaicin.	Capsaicin	235-244	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-4
12812762-0	2003	A tyrosine residue in TM6 of the Vanilloid Receptor TRPV1 involved in desensitization and calcium permeability of capsaicin-activated currents.	Capsaicin	114-123	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
12835535-6	2003	In the nervous system, PAR-2 present in capsaicin-sensitive sensory neurons participates in processing of pain information.	Capsaicin	40-49	F2R like trypsin receptor 1	Homo sapiens	23-28
12802203-1	2003	The vanilloid receptor TRPV1 is a ligand-gated cation channel that can be activated by capsaicin, acids and noxious heat.	Capsaicin	87-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-28
12802203-2	2003	For vanilloids, a stretch of approximately 8 amino acids in the vicinity of the TM3 region on the cytosolic side of TRPV1 and R114 and E761 in the N- and C-cytosolic tails, respectively, has been shown to be critical for capsaicin binding and channel activation.	Capsaicin	221-230	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-121
12768286-3	2003	Neurochemical characterization of extrinsic primary afferent neurons (EPANs) in normal and capsaicin-treated mice, revealed that CGRP and VR1, but not SP, were expressed in extrinsic afferents.	Capsaicin	91-100	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	129-133
12768286-3	2003	Neurochemical characterization of extrinsic primary afferent neurons (EPANs) in normal and capsaicin-treated mice, revealed that CGRP and VR1, but not SP, were expressed in extrinsic afferents.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	138-141
12726827-8	2003	Another highly lipophilic capsaicin analogue, olvanil, was similar to capsiate in that it did not produce irritant responses when applied to the skin surface, although it could activate TRPV1.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	186-191
12884755-2	2003	The cloned capsaicin receptor (TRPV1) is a nonselective cation channel with six transmembrane domains, and is activated not only by capsaicin but also by noxious heat (> 43 degrees C) or protons (acidification), both of which cause pain in vivo.	Capsaicin	11-20	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
12884755-6	2003	In cells expressing TRPV1, ATP or bradykinin increased the currents evoked by capsaicin or protons through activation of metabotropic P2Y or B2 bradykinin receptors.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-25
12679376-4	2003	The elevation in mEPSC frequency occurred at concentrations of capsaicin (100 nM) that did not alter the distribution of mEPSC amplitudes and was abolished by a dorsal rhizotomy, demonstrating that capsaicin acts via presynaptic VR1 receptors localized on primary afferents.	Capsaicin	198-207	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	229-232
12709508-1	2003	Capsaicin, the pungent substance in hot peppers, evokes a sensation of burning pain by stimulating the vanilloid receptor 1 (VR1) on primary afferent neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	125-128
12709508-5	2003	The finding that VR1 is expressed not only in primary afferents but also in oral epithelial cells suggests that it is of great importance in the perception of capsaicin, heat, and acid in the mouth.	Capsaicin	159-168	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	17-20
12692270-4	2003	Using an in vitro neuronal model to study HSV-1 latency and reactivation, we found that agonists of the VR-1 channel - capsaicin and heat - resulted in reactivation of latent HSV-1.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-108
12721390-7	2003	Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-21
12710904-2	2003	Calcitonin gene-related peptide (CGRP), a major transmitter in capsaicin-sensitive sensory nerves, is widely distributed in cardiovascular tissues and the release of CGRP is regulated by multiple autacoids including nitric oxide (NO).	Capsaicin	63-72	calcitonin related polypeptide alpha	Homo sapiens	0-31
12710904-2	2003	Calcitonin gene-related peptide (CGRP), a major transmitter in capsaicin-sensitive sensory nerves, is widely distributed in cardiovascular tissues and the release of CGRP is regulated by multiple autacoids including nitric oxide (NO).	Capsaicin	63-72	calcitonin related polypeptide alpha	Homo sapiens	33-37
12710904-2	2003	Calcitonin gene-related peptide (CGRP), a major transmitter in capsaicin-sensitive sensory nerves, is widely distributed in cardiovascular tissues and the release of CGRP is regulated by multiple autacoids including nitric oxide (NO).	Capsaicin	63-72	calcitonin related polypeptide alpha	Homo sapiens	166-170
12719786-6	2003	AEA-induced EC death was inhibited by a selective vanilloid receptor 1 (VR1) antagonist, capsazepine, and was enhanced by a VR1 agonist, capsaicin, indicating that AEA induces apoptosis in ECs via VR1.	Capsaicin	137-146	transient receptor potential cation channel subfamily V member 1	Homo sapiens	124-127
12719786-6	2003	AEA-induced EC death was inhibited by a selective vanilloid receptor 1 (VR1) antagonist, capsazepine, and was enhanced by a VR1 agonist, capsaicin, indicating that AEA induces apoptosis in ECs via VR1.	Capsaicin	137-146	transient receptor potential cation channel subfamily V member 1	Homo sapiens	124-127
12721390-7	2003	Conversely, the TRPV1 antagonist capsazepine, as well as calcium chelation by EGTA ablated cytokine (IL-6) production after capsaicin exposure.	Capsaicin	124-133	interleukin 6	Homo sapiens	101-105
12721390-10	2003	Surprisingly, the cytotoxic effects of capsaicin in TRPV1 overexpressing cells were also not inhibited by TRPV1 antagonists or by treatments that modified extracellular calcium.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
12721390-11	2003	Thus, capsaicin interacted with TRPV1 expressed by BEAS-2B and other airway epithelial cells to cause the calcium-dependent production of cytokines and, conversely, calcium-independent cell death.	Capsaicin	6-15	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
12721390-13	2003	The mechanisms of these cellular responses to capsaicinoids appear to proceed via distinct cellular pathways, but both pathways are initiated by TRPV1.	Capsaicin	46-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	145-150
12694812-5	2003	In segments from young SHRs, the treatment with the calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP-(8-37), induced an increase in the electrical field stimulation-induced vasoconstrictor response that was not modified by the subsequent addition of capsaicin.	Capsaicin	266-275	calcitonin-related polypeptide alpha	Rattus norvegicus	52-83
12694812-5	2003	In segments from young SHRs, the treatment with the calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP-(8-37), induced an increase in the electrical field stimulation-induced vasoconstrictor response that was not modified by the subsequent addition of capsaicin.	Capsaicin	266-275	calcitonin-related polypeptide alpha	Rattus norvegicus	85-89
12694812-5	2003	In segments from young SHRs, the treatment with the calcitonin gene-related peptide (CGRP) receptor antagonist, CGRP-(8-37), induced an increase in the electrical field stimulation-induced vasoconstrictor response that was not modified by the subsequent addition of capsaicin.	Capsaicin	266-275	calcitonin-related polypeptide alpha	Rattus norvegicus	112-116
12741457-6	2003	Capsaicin treatment prevented the irradiation from affecting SP-induced contractile response or increasing neurotensin levels.	Capsaicin	0-9	neurotensin	Rattus norvegicus	107-118
12706472-7	2003	The MED15 enteroprotective effect is related to stimulation of intestinal capsaicin receptors as demonstrated by the loss of protective effect in the presence of capsazepine, a specific receptor antagonist of capsaicin.	Capsaicin	74-83	mediator complex subunit 15	Rattus norvegicus	4-9
12569099-7	2003	These findings demonstrate the existence of an endogenous compound in the brain that is similar to capsaicin and NADA in its chemical structure and activity on VR1.	Capsaicin	99-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-163
12682265-7	2003	Taken together our data show that both NO and capsaicin-sensitive afferent neurons are involved in PAR-2-mediated colonic inflammation and paracellular permeability increase.	Capsaicin	46-55	coagulation factor II (thrombin) receptor-like 1	Mus musculus	99-104
12716921-3	2003	The VR1 agonist capsaicin increased the frequency of both TTX-sensitive and -insensitive spontaneous EPSCs (sEPSCs) without affecting their amplitude, suggesting a presynaptic site of action.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-7
12716921-6	2003	The VR1 antagonists capsazepine and iodoresiniferatoxin (IRTX) blocked the effects of capsaicin.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-7
12651937-0	2003	beta 2-Adrenoceptor regulation of CGRP release from capsaicin-sensitive neurons.	Capsaicin	52-61	adrenoceptor beta 2	Bos taurus	0-19
12651937-6	2003	In addition, application of albuterol, a selective beta(2)-adrenoceptor agonist, significantly blocked capsaicin-evoked release of iCGRP.	Capsaicin	103-112	adrenoceptor beta 2	Bos taurus	51-71
12562891-5	2003	Application of the VR1 receptor agonist capsaicin (300 nM) caused a 4200 % increase in the mEPSC rate.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	19-22
12649350-4	2003	Depletion of primary afferent nerve fibers by neonatal capsaicin treatment down-regulated circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) and protected mice from GalN/LPS-induced liver injury.	Capsaicin	55-64	tumor necrosis factor	Mus musculus	142-169
12649350-4	2003	Depletion of primary afferent nerve fibers by neonatal capsaicin treatment down-regulated circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) and protected mice from GalN/LPS-induced liver injury.	Capsaicin	55-64	tumor necrosis factor	Mus musculus	171-179
12562891-8	2003	Co-application of the VR1 antagonist capsazepine (30 microM) completely reversed the effects of both capsaicin and anandamide.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-25
12649350-4	2003	Depletion of primary afferent nerve fibers by neonatal capsaicin treatment down-regulated circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) and protected mice from GalN/LPS-induced liver injury.	Capsaicin	55-64	interferon gamma	Mus musculus	185-201
12604682-0	2003	Facilitation by endogenous prostaglandins of capsaicin-induced gastric protection in rodents through EP2 and IP receptors.	Capsaicin	45-54	prostaglandin E receptor 2 (subtype EP2)	Mus musculus	101-104
12649350-4	2003	Depletion of primary afferent nerve fibers by neonatal capsaicin treatment down-regulated circulating levels of the proinflammatory cytokines tumor necrosis factor-alpha (TNFalpha) and interferon-gamma (IFNgamma) and protected mice from GalN/LPS-induced liver injury.	Capsaicin	55-64	interferon gamma	Mus musculus	203-211
12654248-7	2003	Consistent with the expression of ANKTM1, we identify noxious cold-sensitive sensory neurons that also respond to capsaicin but not to menthol.	Capsaicin	114-123	transient receptor potential cation channel subfamily A member 1	Homo sapiens	34-40
12586218-0	2003	Transforming growth factor alpha-mediated gastroprotection against stress ulceration in the rat: involvement of capsaicin-sensitive sensory neurons.	Capsaicin	112-121	transforming growth factor alpha	Rattus norvegicus	0-32
12586218-14	2003	We conclude that: 1) TGF alpha caused dose-dependent gastroprotection against WRS ulceration, 2) TGF alpha-mediated gastric mucosal protection was prevented by capsaicin-induced sensory denervation and, 3) stress-induced injury was associated with significant reduction in gastric content of both TGF alpha and CGRP.	Capsaicin	160-169	transforming growth factor alpha	Rattus norvegicus	21-30
12586218-14	2003	We conclude that: 1) TGF alpha caused dose-dependent gastroprotection against WRS ulceration, 2) TGF alpha-mediated gastric mucosal protection was prevented by capsaicin-induced sensory denervation and, 3) stress-induced injury was associated with significant reduction in gastric content of both TGF alpha and CGRP.	Capsaicin	160-169	transforming growth factor alpha	Rattus norvegicus	97-106
12586218-14	2003	We conclude that: 1) TGF alpha caused dose-dependent gastroprotection against WRS ulceration, 2) TGF alpha-mediated gastric mucosal protection was prevented by capsaicin-induced sensory denervation and, 3) stress-induced injury was associated with significant reduction in gastric content of both TGF alpha and CGRP.	Capsaicin	160-169	transforming growth factor alpha	Rattus norvegicus	97-106
12586218-14	2003	We conclude that: 1) TGF alpha caused dose-dependent gastroprotection against WRS ulceration, 2) TGF alpha-mediated gastric mucosal protection was prevented by capsaicin-induced sensory denervation and, 3) stress-induced injury was associated with significant reduction in gastric content of both TGF alpha and CGRP.	Capsaicin	160-169	calcitonin-related polypeptide alpha	Rattus norvegicus	311-315
12594053-6	2003	In concordance with vanilloid receptor 1 expression on these nerve terminals, the spinal sensory substance P/calcitionin gene-related peptide-IR component of the innervation of NEBs was depleted by systemic capsaicin treatment.	Capsaicin	207-216	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	20-40
12642400-5	2003	(3) We have demonstrated that I-RTX inhibited capsaicin-induced mobilization of intracellular Ca(2+) in rat trigeminal neurons (IC(50) 0.87 nM) and in HEK293 cells transfected with the human TRPV1 (IC(50) 0.071 nM).	Capsaicin	46-55	transient receptor potential cation channel subfamily V member 1	Homo sapiens	191-196
12642400-6	2003	(4) Furthermore, I-RTX significantly inhibited both capsaicin-induced CGRP release from slices of rat dorsal spinal cord (IC(50) 0.27 nM) and contraction of isolated guinea-pig and rat urinary bladder (pK(B) of 10.68 and 9.63, respectively), whilst I-RTX failed to alter the response to high KCl or SP.	Capsaicin	52-61	calcitonin related polypeptide alpha	Homo sapiens	70-74
12658436-1	2003	The vanilloid receptor VR1 is a nonselective cation channel activated by capsaicin as well as increases in temperature and acidity, and can be viewed as molecular integrator of chemical and physical stimuli that elicit pain.	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	23-26
12737320-3	2003	After a 5-min pre-treatment, HU-210 (0.1 microM) significantly enhanced the effect of several concentrations of capsaicin on [Ca2+]i in HEK-293 cells over-expressing both rat CB1 and human VR1 (CB1-VR1-HEK cells), but not in cells over-expressing only human VR1 (VR1-HEK cells).	Capsaicin	112-121	cannabinoid receptor 1	Rattus norvegicus	175-178
12737320-3	2003	After a 5-min pre-treatment, HU-210 (0.1 microM) significantly enhanced the effect of several concentrations of capsaicin on [Ca2+]i in HEK-293 cells over-expressing both rat CB1 and human VR1 (CB1-VR1-HEK cells), but not in cells over-expressing only human VR1 (VR1-HEK cells).	Capsaicin	112-121	vault RNA 1-1	Homo sapiens	189-192
12737320-3	2003	After a 5-min pre-treatment, HU-210 (0.1 microM) significantly enhanced the effect of several concentrations of capsaicin on [Ca2+]i in HEK-293 cells over-expressing both rat CB1 and human VR1 (CB1-VR1-HEK cells), but not in cells over-expressing only human VR1 (VR1-HEK cells).	Capsaicin	112-121	cannabinoid receptor 1	Homo sapiens	194-201
12737320-3	2003	After a 5-min pre-treatment, HU-210 (0.1 microM) significantly enhanced the effect of several concentrations of capsaicin on [Ca2+]i in HEK-293 cells over-expressing both rat CB1 and human VR1 (CB1-VR1-HEK cells), but not in cells over-expressing only human VR1 (VR1-HEK cells).	Capsaicin	112-121	vault RNA 1-1	Homo sapiens	198-201
12737320-3	2003	After a 5-min pre-treatment, HU-210 (0.1 microM) significantly enhanced the effect of several concentrations of capsaicin on [Ca2+]i in HEK-293 cells over-expressing both rat CB1 and human VR1 (CB1-VR1-HEK cells), but not in cells over-expressing only human VR1 (VR1-HEK cells).	Capsaicin	112-121	vault RNA 1-1	Homo sapiens	198-201
12604668-0	2003	Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-40
12604668-0	2003	Novel expression of vanilloid receptor 1 on capsaicin-insensitive fibers accounts for the analgesic effect of capsaicin cream in neuropathic pain.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-40
12604668-14	2003	Finally, novel expression of VR1 receptors on neonatal capsaicin-insensitive neurons after nerve injury was confirmed by immunohistochemistry.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-32
12618348-7	2003	A decrease of the CD-induced c-fos expression after sensory vagal denervation by perivagal capsaicin treatment was only observed in brainstem nuclei (NTS and RVLM).	Capsaicin	91-100	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	29-34
12618348-8	2003	In all other activated brain nuclei examined, the CD-related induction of c-fos expression was diminished only after systemic neonatal capsaicin treatment.	Capsaicin	135-144	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-79
12618348-9	2003	In the NTS and RVLM, a trend of decrease of c-fos expression was also observed after systemic neonatal capsaicin treatment.	Capsaicin	103-112	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	44-49
12618348-15	2003	In contrast, activation of brain nuclei in the di- and telencephalon by nociceptive mechanical stimulation of the proximal colon, as assessed by c-fos expression, is partially mediated by capsaicin-sensitive, non-vagal afferents, and independent of neurotransmission via 5-HT(3) receptors.	Capsaicin	188-197	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-150
12531428-0	2003	Capsaicin exhibits anti-inflammatory property by inhibiting IkB-a degradation in LPS-stimulated peritoneal macrophages.	Capsaicin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	60-63
12531428-6	2003	Capsaicin did not affect the COX-2 expression at either the protein or mRNA level, but inhibited the enzyme activity of COX-2 and the expression of the iNOS protein.	Capsaicin	0-9	cytochrome c oxidase II, mitochondrial	Mus musculus	120-125
12531428-6	2003	Capsaicin did not affect the COX-2 expression at either the protein or mRNA level, but inhibited the enzyme activity of COX-2 and the expression of the iNOS protein.	Capsaicin	0-9	nitric oxide synthase 2, inducible	Mus musculus	152-156
12531428-7	2003	Capsaicin completely blocked LPS-induced disappearance of IkB-a and therefore inactivated NF-kB.	Capsaicin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, beta	Mus musculus	58-61
12737320-6	2003	Pre-treatment of CB1-VR1-HEK cells with forskolin, an adenylate cyclase activator, enhanced the capsaicin effect on [Ca2+]i. HU-210, which in the same cells inhibits forskolin-induced enhancement of cAMP levels, blocked the stimulatory effect of forskolin on capsaicin.	Capsaicin	96-105	cannabinoid receptor 1	Homo sapiens	17-24
12737320-6	2003	Pre-treatment of CB1-VR1-HEK cells with forskolin, an adenylate cyclase activator, enhanced the capsaicin effect on [Ca2+]i. HU-210, which in the same cells inhibits forskolin-induced enhancement of cAMP levels, blocked the stimulatory effect of forskolin on capsaicin.	Capsaicin	259-268	cannabinoid receptor 1	Homo sapiens	17-24
12737320-7	2003	Our data suggest that in cells co-expressing both CB1 and VR1 receptors, pre-treatment with CB1 agonists inhibits or stimulates VR1 gating by capsaicin depending on whether or not cAMP-mediated signalling has been concomitantly activated.	Capsaicin	142-151	cannabinoid receptor 1	Homo sapiens	50-53
12737320-7	2003	Our data suggest that in cells co-expressing both CB1 and VR1 receptors, pre-treatment with CB1 agonists inhibits or stimulates VR1 gating by capsaicin depending on whether or not cAMP-mediated signalling has been concomitantly activated.	Capsaicin	142-151	vault RNA 1-1	Homo sapiens	58-61
12737320-7	2003	Our data suggest that in cells co-expressing both CB1 and VR1 receptors, pre-treatment with CB1 agonists inhibits or stimulates VR1 gating by capsaicin depending on whether or not cAMP-mediated signalling has been concomitantly activated.	Capsaicin	142-151	cannabinoid receptor 1	Homo sapiens	92-95
12737320-7	2003	Our data suggest that in cells co-expressing both CB1 and VR1 receptors, pre-treatment with CB1 agonists inhibits or stimulates VR1 gating by capsaicin depending on whether or not cAMP-mediated signalling has been concomitantly activated.	Capsaicin	142-151	vault RNA 1-1	Homo sapiens	128-131
12626618-5	2003	In capsaicin-insensitive (CIS) rat TG neurons, or small-diameter mouse VR1-/- neurons, 1 microM capsaicin inhibited I(A) currents 9 and 3%, respectively.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	71-74
12626618-11	2003	That activation, partially through the activation of cGMP-PKG and calmodulin-dependent pathways should result in increased excitability of capsaicin-sensitive nociceptors.	Capsaicin	139-148	calmodulin 1	Rattus norvegicus	66-76
12478662-0	2003	Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.	Capsaicin	62-71	mitogen-activated protein kinase 8	Homo sapiens	9-14
12537981-5	2003	Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.	Capsaicin	0-9	NFKB inhibitor alpha	Homo sapiens	77-92
12537981-5	2003	Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	123-150
12537981-5	2003	Capsaicin treatment also induced the degradation of Tax and up-regulation of I kappa-B alpha, resulting in the decrease of nuclear factor (NF)-kappa B/p65 DNA binding activity.	Capsaicin	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	151-154
12566162-0	2003	Flurbiprofen inhibits capsaicin induced calcitonin gene related peptide release from rat spinal cord via an endocannabinoid dependent mechanism.	Capsaicin	22-31	calcitonin-related polypeptide alpha	Rattus norvegicus	40-71
12566162-2	2003	In the spinal superperfusion model, Delta(9) tetrahydrocannabinol inhibited capsaicin induced CGRP release in a concentration dependent manner.	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	94-98
12454015-2	2003	The VR1 agonist capsaicin induced Ca(2+) mobilization from intracellular stores in the absence of extracellular Ca(2+), and this release was inhibited by the VR1 antagonist capsazepine but was unaffected by the phospholipase C inhibitor xestospongins, indicating that Ca(2+) mobilization was dependent on capsaicin receptor binding and was not due to intracellular inositol-1,4,5-trisphosphate generation.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-7
12454015-2	2003	The VR1 agonist capsaicin induced Ca(2+) mobilization from intracellular stores in the absence of extracellular Ca(2+), and this release was inhibited by the VR1 antagonist capsazepine but was unaffected by the phospholipase C inhibitor xestospongins, indicating that Ca(2+) mobilization was dependent on capsaicin receptor binding and was not due to intracellular inositol-1,4,5-trisphosphate generation.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	158-161
12454015-4	2003	The main part of the capsaicin-releasable Ca(2+) store was insensitive to thapsigargin, a selective endoplasmic reticulum Ca(2+)-ATPase inhibitor, suggesting that VR1 might be predominantly localized to a thapsigargin-insensitive endoplasmic reticulum Ca(2+) store.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	163-166
12478662-0	2003	Roles of JNK-1 and p38 in selective induction of apoptosis by capsaicin in ras-transformed human breast epithelial cells.	Capsaicin	62-71	mitogen-activated protein kinase 14	Homo sapiens	19-22
12478662-6	2003	In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs).	Capsaicin	23-32	mitogen-activated protein kinase 8	Homo sapiens	62-101
12478662-6	2003	In H-ras MCF10A cells, capsaicin treatment markedly activated c-Jun N-terminal protein kinase (JNK)-1 and p38 matigen-activated protein kinase (MAPK) while it deactivated extracellular signal-regulated protein kinases (ERKs).	Capsaicin	23-32	mitogen-activated protein kinase 14	Homo sapiens	106-109
12478662-7	2003	The use of kinase inhibitors and overexpression of dominant-negative forms of MAPKs demonstrated a role of JNK-1 and p38, but not that of ERKs, in apoptosis induced by capsaicin in H-ras-transformed MCF10A cells.	Capsaicin	168-177	mitogen-activated protein kinase 8	Homo sapiens	107-112
12478662-7	2003	The use of kinase inhibitors and overexpression of dominant-negative forms of MAPKs demonstrated a role of JNK-1 and p38, but not that of ERKs, in apoptosis induced by capsaicin in H-ras-transformed MCF10A cells.	Capsaicin	168-177	mitogen-activated protein kinase 14	Homo sapiens	117-120
12624816-4	2003	In aortic and superior mesenteric arterial rings, rutaecarpine (10 (-7)-10(-5) M) or capsaicin (3 x 10(-9)-3 x 10(-6) M) caused a concentration-dependent vasodilator response, which was significantly attenuated by capsazepine (10(-5) M), a competitive vanilloid receptor antagonist, or by CGRP-(8-37) (10(-6) M), a selective CGRP receptor antagonist.	Capsaicin	85-94	calcitonin-related polypeptide alpha	Rattus norvegicus	289-293
12542603-13	2003	The stimulatory effect of co-injection of TRH analog and lafutidine was abolished by systemic capsaicin-treatment and CGRP antagonist.	Capsaicin	94-103	thyrotropin releasing hormone	Rattus norvegicus	42-45
12542603-14	2003	CONCLUSION: These data suggest that lafutidine increases hepatic blood flow by sensitizing the liver to the action of central TRH via both capsaicin-sensitive sensory neurons and endogenous CGRP in urethane-anesthetized rats.	Capsaicin	139-148	thyrotropin releasing hormone	Rattus norvegicus	126-129
12588467-6	2003	Pre-treatment with capsaicin or hexamethonium or a combination of both pre-treatments reduced HCl-induced c-Fos expression by 54, 66 and 63%, respectively.	Capsaicin	19-28	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	106-111
12624816-4	2003	In aortic and superior mesenteric arterial rings, rutaecarpine (10 (-7)-10(-5) M) or capsaicin (3 x 10(-9)-3 x 10(-6) M) caused a concentration-dependent vasodilator response, which was significantly attenuated by capsazepine (10(-5) M), a competitive vanilloid receptor antagonist, or by CGRP-(8-37) (10(-6) M), a selective CGRP receptor antagonist.	Capsaicin	85-94	calcitonin-related polypeptide alpha	Rattus norvegicus	325-329
12473388-1	2003	This study compared the actions of members of five different chemical classes of vanilloid agonists at the recombinant rat vanilloid VR1 receptor expressed in HEK293 cells, and at endogenous vanilloid receptors on dorsal root ganglion cells and sensory nerves in the rat isolated mesenteric arterial bed.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	133-136
12473388-5	2003	In VR1-HEK293 cells and dorsal root ganglion neurones, Ca(2+) responses were induced by resiniferatoxin>capsaicin=olvanil>PPAHV; all four were full agonists.	Capsaicin	107-116	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	3-6
12473388-8	2003	Olvanil had a Hill coefficient of approximately 1 whilst capsaicin, resiniferatoxin and PPAHV had Hill coefficients of approximately 2 in VR1-HEK293 cells.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	138-141
12473388-10	2003	These data show that resiniferatoxin, capsaicin, olvanil and PPAHV, but not scutigeral and isovelleral, are agonists at recombinant rat VR1 receptors and endogenous vanilloid receptors on dorsal root ganglion neurones and in the rat mesenteric arterial bed.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-139
14695935-3	2003	Low concentrations of capsaicin like CoQ1 inhibited ROS formation but CoQ1 was more effective at restoring the mitochondrial membrane potential collapse caused by complex 1 inhibitors such as rotenone.	Capsaicin	22-31	decaprenyl diphosphate synthase subunit 1	Homo sapiens	37-41
14695935-3	2003	Low concentrations of capsaicin like CoQ1 inhibited ROS formation but CoQ1 was more effective at restoring the mitochondrial membrane potential collapse caused by complex 1 inhibitors such as rotenone.	Capsaicin	22-31	decaprenyl diphosphate synthase subunit 1	Homo sapiens	70-74
12520409-3	2003	Following nicotine and capsaicin, there was a significant increase in fos-like immunoreactivity (FLI) compared with controls in the following areas: nucleus of the solitary tract from the level of the pyramidal decussation caudally to the level of the area postrema rostrally; dorsomedial aspect of trigeminal subnucleus caudalis (Vc); and paratrigeminal islands interspersed in the spinal trigeminal tract.	Capsaicin	23-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	70-73
12522087-9	2003	We conclude that VR1 is able to couple to Ca2+ mobilization by a Ca2+ dependent mechanism, mediated by capsaicin and RTX, and a Ca2+ independent mechanism mediated by RTX alone.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-20
12522087-1	2003	1 Capsaicin and resiniferatoxin (RTX) stimulate Ca2+ influx by activating vanilloid receptor 1 (VR1), a ligand-gated Ca2+ channel on sensory neurones.	Capsaicin	2-11	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-94
12522087-1	2003	1 Capsaicin and resiniferatoxin (RTX) stimulate Ca2+ influx by activating vanilloid receptor 1 (VR1), a ligand-gated Ca2+ channel on sensory neurones.	Capsaicin	2-11	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-99
12490594-9	2003	Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2, and the stimulated release was attenuated by capsazepine.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-31
12527134-1	2003	The type 1 vanilloid receptor (VR1) is a non-specific cation channel activated by capsaicin, lipoxygenase (LOX) products, heat and acid.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	31-34
12490575-1	2003	Vanilloid receptor type 1 (VR1) (TRPV1) is a ligand-gated ion channel expressed on sensory nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin.	Capsaicin	167-176	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-30
12490575-1	2003	Vanilloid receptor type 1 (VR1) (TRPV1) is a ligand-gated ion channel expressed on sensory nerves that responds to noxious heat, protons, and chemical stimuli such as capsaicin.	Capsaicin	167-176	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	33-38
12490594-3	2003	The recently cloned vanilloid receptor-1 (VR1) is a polymodal receptor, responding to thermal, pH, or vanilloids such as capsaicin stimulation.	Capsaicin	121-130	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-40
12490594-9	2003	Activation of the epidermal VR1 by capsaicin also resulted in an increased release of interleukin-8 and prostaglandin E2, and the stimulated release was attenuated by capsazepine.	Capsaicin	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	86-99
12490594-3	2003	The recently cloned vanilloid receptor-1 (VR1) is a polymodal receptor, responding to thermal, pH, or vanilloids such as capsaicin stimulation.	Capsaicin	121-130	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-45
14596864-0	2003	Increased phosphorylation of the GluR1 subunit of spinal cord alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate receptor in rats following intradermal injection of capsaicin.	Capsaicin	168-177	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	33-38
12490594-6	2003	Consistent with neuronal VR1, activation of epidermal VR1 by capsaicin induced a calcium influx.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	54-57
12490594-7	2003	Treating HaCaT cells with capsaicin resulted in a dose-dependent expression of cyclooxygenase-2 (COX-2), whereas pretreatment with the VR1 receptor antagonist capsazepine abolished the capsaicin-stimulated increase in COX-2 expression.	Capsaicin	26-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	79-95
12490594-7	2003	Treating HaCaT cells with capsaicin resulted in a dose-dependent expression of cyclooxygenase-2 (COX-2), whereas pretreatment with the VR1 receptor antagonist capsazepine abolished the capsaicin-stimulated increase in COX-2 expression.	Capsaicin	26-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	97-102
12490594-7	2003	Treating HaCaT cells with capsaicin resulted in a dose-dependent expression of cyclooxygenase-2 (COX-2), whereas pretreatment with the VR1 receptor antagonist capsazepine abolished the capsaicin-stimulated increase in COX-2 expression.	Capsaicin	26-35	prostaglandin-endoperoxide synthase 2	Homo sapiens	218-223
12490594-7	2003	Treating HaCaT cells with capsaicin resulted in a dose-dependent expression of cyclooxygenase-2 (COX-2), whereas pretreatment with the VR1 receptor antagonist capsazepine abolished the capsaicin-stimulated increase in COX-2 expression.	Capsaicin	185-194	prostaglandin-endoperoxide synthase 2	Homo sapiens	79-95
12490594-7	2003	Treating HaCaT cells with capsaicin resulted in a dose-dependent expression of cyclooxygenase-2 (COX-2), whereas pretreatment with the VR1 receptor antagonist capsazepine abolished the capsaicin-stimulated increase in COX-2 expression.	Capsaicin	185-194	transient receptor potential cation channel subfamily V member 1	Homo sapiens	135-138
12490594-8	2003	Furthermore, the capsaicin-induced expression of COX-2 was dependent on extracellular calcium.	Capsaicin	17-26	prostaglandin-endoperoxide synthase 2	Homo sapiens	49-54
14568027-3	2003	NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-149
14568027-5	2003	Incubating the root with capsaicin produced NK1R internalization in the ipsilateral dorsal horn that was abolished when capsazepine or lidocaine was included in, or when Ca(2+) was omitted from, the medium surrounding the root.	Capsaicin	25-34	tachykinin receptor 1	Rattus norvegicus	44-48
14596864-6	2003	A significant upregulation of phospho-GluR1 both at Ser-831 and Ser-845 was found by 5 min after capsaicin treatment, and this increase lasted at least 60 min.	Capsaicin	97-106	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	38-43
14568027-2	2003	To determine whether these two actions have different mechanisms, we measured neurokinin 1 receptor (NK1R) internalization in rat spinal cord slices elicited by incubating the whole slice or just the dorsal root with capsaicin.	Capsaicin	217-226	tachykinin receptor 1	Rattus norvegicus	78-99
14568027-2	2003	To determine whether these two actions have different mechanisms, we measured neurokinin 1 receptor (NK1R) internalization in rat spinal cord slices elicited by incubating the whole slice or just the dorsal root with capsaicin.	Capsaicin	217-226	tachykinin receptor 1	Rattus norvegicus	101-105
14568027-3	2003	NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine.	Capsaicin	60-69	tachykinin receptor 1	Rattus norvegicus	0-4
14568027-3	2003	NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine.	Capsaicin	60-69	tachykinin receptor 1	Rattus norvegicus	91-95
14568027-3	2003	NK1R internalization produced by incubating the slices with capsaicin was abolished by the NK1R antagonist RP-67580, by the vanilloid receptor 1 (VR1) antagonist capsazepine, and by eliminating Ca(2+) from the medium, but was not affected by the Na(+) channel blocker lidocaine.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	124-144
12699788-0	2003	Relationship between capsaicin-evoked substance P release and neurokinin 1 receptor internalization in the rat spinal cord.	Capsaicin	21-30	tachykinin receptor 1	Rattus norvegicus	62-83
12699788-3	2003	Our objective was to compare substance P release and NK1 receptor internalization produced by capsaicin in rat spinal cord slices.	Capsaicin	94-103	tachykinin receptor 1	Rattus norvegicus	53-65
12699788-9	2003	The correlation was good for laminae I (R(2)=0.82) and III (R(2)=0.78), but it was poor (R(2)=0.35) for lamina IV because NK1 receptor internalization kept on increasing at high concentrations of capsaicin, whereas substance P release decreased.	Capsaicin	196-205	tachykinin receptor 1	Rattus norvegicus	122-134
12361955-6	2002	When overexpressed in Jurkat cells, CaT1 produces a Ca(2+) entry current that mimics the endogenous I(CRAC) in its dependence on external Ca(2+), inactivation by elevated concentration of internal Ca(2+), and pharmacological block by capsaicin.	Capsaicin	234-243	transient receptor potential cation channel subfamily V member 6	Homo sapiens	36-40
12470868-0	2002	The effects of sympathectomy on capsaicin-evoked fos expression of spinal dorsal horn GABAergic neurons.	Capsaicin	32-41	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-52
12527482-3	2002	The present study was designed to investigate effects of IL-2 on the physiological properties of capsaicin-sensitive small dorsal root ganglion (DRG) neurons, which are predominantly responsible for nociceptive transmission from the periphery to the spinal cord.	Capsaicin	97-106	interleukin 2	Rattus norvegicus	57-61
12498288-8	2002	Capsaicin evoked an increase in [Ca2+]i in rat VR1-transfected HEK293 cells, while lafutidine had no effect by itself on [Ca2+]i in these cells and did not affect the increase in [Ca2+]i evoked by capsaicin.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	47-50
12453933-5	2002	METHODS: Using a Flurometric Imaging Plate Reader (FLIPR), calcium imaging has been used to study the effects of several vanilloid and cannabinoid ligands in rat VR1-transfected HEK293 (rVR1-HEK) cells and in DRG cells.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	162-165
12453933-10	2002	Reapplication of VR1 agonists significantly inhibited a subsequent challenge to either capsaicin or anandamide in either cell type, whilst pre-exposure to cannabinoid agonists were without effect.	Capsaicin	87-96	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	17-20
19003109-5	2002	We showed that after capsaicin treatment, HSP47 was activated.	Capsaicin	21-30	serpin family H member 1	Homo sapiens	42-47
19003109-7	2002	These results suggest that, while PKC is not involved, it is highly possible that HSP47plays a role in TJ permeability increase in intestinal Caco-2 cells exposed to capsaicin.	Capsaicin	166-175	serpin family H member 1	Homo sapiens	82-87
12588046-4	2002	Wistar rats were made CGRP deficient by treatment with capsaicin (50 mg/kg) 1-3 d after birth.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	22-26
12354577-2	2002	They are activated by a variety of physical and chemical stimuli, characteristically by capsaicin acting via the vanilloid receptor VR1, and have a role in the regulation of peripheral vascular resistance and maintenance of homeostasis via their afferent and efferent functions.	Capsaicin	88-97	vault RNA 1-1	Homo sapiens	132-135
12417686-8	2002	Capsaicin deafferentation abolished the peripheral effects of both cannabinoid agonists and antagonists, suggesting that these agents modulate food intake by acting on CB1 receptors located on capsaicin-sensitive sensory terminals.	Capsaicin	0-9	cannabinoid receptor 1	Rattus norvegicus	168-171
12417686-8	2002	Capsaicin deafferentation abolished the peripheral effects of both cannabinoid agonists and antagonists, suggesting that these agents modulate food intake by acting on CB1 receptors located on capsaicin-sensitive sensory terminals.	Capsaicin	193-202	cannabinoid receptor 1	Rattus norvegicus	168-171
12572881-7	2002	Mucus secretion in response to luminal acid was delayed by an interruption to the capsaicin pathway, which includes VR, capsaicin-sensitive afferent nerves, CGRP, and NO, and was abolished by COX inhibition.	Capsaicin	82-91	calcitonin-related polypeptide alpha	Rattus norvegicus	157-161
12414119-1	2002	Pungent sensation of hot peppers is thought to be mediated by vanilloid receptor subtype-1 (VR1), which can be activated by capsaicin, but there is little information regarding its histological localization in the tongue.	Capsaicin	124-133	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-90
12414119-1	2002	Pungent sensation of hot peppers is thought to be mediated by vanilloid receptor subtype-1 (VR1), which can be activated by capsaicin, but there is little information regarding its histological localization in the tongue.	Capsaicin	124-133	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	92-95
12414119-10	2002	Although VR1-immunoreactivity was not observed in taste-bud cells, our findings that a large number of VR1-IR fibers concentrated in the taste papillae suggest that capsaicin easily reaches the VR1 nerve terminals because of its lipophilic nature.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-12
12414119-10	2002	Although VR1-immunoreactivity was not observed in taste-bud cells, our findings that a large number of VR1-IR fibers concentrated in the taste papillae suggest that capsaicin easily reaches the VR1 nerve terminals because of its lipophilic nature.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-106
12414119-10	2002	Although VR1-immunoreactivity was not observed in taste-bud cells, our findings that a large number of VR1-IR fibers concentrated in the taste papillae suggest that capsaicin easily reaches the VR1 nerve terminals because of its lipophilic nature.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-106
12228057-7	2002	Moreover, left adrenalectomy induced c-Fos immunolabeling in ipsilateral dorsal spinal cord that was prevented by capsaicin treatment.	Capsaicin	114-123	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-42
12388616-1	2002	In previous studies, we have shown that loss of spinal neurons that possess the substance P receptor (SPR) attenuated pain and hyperalgesia produced by capsaicin, inflammation, and nerve injury.	Capsaicin	152-161	tachykinin receptor 1	Homo sapiens	80-100
12388616-1	2002	In previous studies, we have shown that loss of spinal neurons that possess the substance P receptor (SPR) attenuated pain and hyperalgesia produced by capsaicin, inflammation, and nerve injury.	Capsaicin	152-161	tachykinin receptor 1	Homo sapiens	102-105
12388616-5	2002	Loss of SPR-expressing neurons diminished the responses of remaining neurons to intraplantar injection of capsaicin.	Capsaicin	106-115	tachykinin receptor 1	Homo sapiens	8-11
12388616-6	2002	Peak responses to 10 microg of capsaicin were approximately 65% lower in animals pretreated with SP-SAP compared with controls.	Capsaicin	31-40	amyloid P component, serum	Homo sapiens	100-103
12223354-8	2002	Neonatal capsaicin administration significantly reduced tissue MPO levels, histological severity scores, and wet-to-dry weight ratio and abolished plasma extravasation.	Capsaicin	9-18	myeloperoxidase	Rattus norvegicus	63-66
12208893-6	2002	RESULTS: The majority of the parental SCC cells underwent apoptosis after a 12-hour exposure to 100 micro M capsaicin or 10 micro M resiniferatoxin.	Capsaicin	108-117	serpin family B member 3	Homo sapiens	38-41
14599363-3	2002	HEK-293 cells, stably expressing rVR1 or hVR1, exhibited dose-dependent increases in [Ca(++)](i) when challenged with capsaicin (EC(50)s congruent with 10 nM).	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	33-37
14599363-3	2002	HEK-293 cells, stably expressing rVR1 or hVR1, exhibited dose-dependent increases in [Ca(++)](i) when challenged with capsaicin (EC(50)s congruent with 10 nM).	Capsaicin	118-127	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-45
14599363-4	2002	Responses to capsaicin were blocked by the VR1 antagonist capsazepine and were dependent on VR1 expression.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-46
14599363-4	2002	Responses to capsaicin were blocked by the VR1 antagonist capsazepine and were dependent on VR1 expression.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-95
12237342-1	2002	The vanilloid receptor VR1 has attracted great interest as a sensory transducer for capsaicin, protons, and heat, and as a therapeutic target.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	23-26
12237342-12	2002	We conclude that JYL1421 is a competitive antagonist of rVR1, blocking response to all three of the agonists (capsaicin, heat, and protons) with enhanced potency relative to capsazepine.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-60
12359623-6	2002	Superfusion of the VR1 agonist capsaicin onto small trigeminal neurons voltage clamped at +40 mV produced outward currents in most cells, with a pEC(50) of 6.3+/-0.1 (maximum currents at 10-30 micro M).	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-22
12589921-4	2002	Activation of trk receptors enhances the response of the vanilloid VR-1 receptor in nociceptive neurons leading to peripheral sensitization of the response to capsaicin or noxious heat.	Capsaicin	159-168	neurotrophic receptor tyrosine kinase 1	Homo sapiens	14-17
12358683-5	2002	Intraduodenal capsaicin inhibited spontaneous and motilin-induced gastric contractions.	Capsaicin	14-23	motilin	Canis lupus familiaris	50-57
12358683-6	2002	The spontaneous peak in plasma motilin was inhibited by intraduodenal capsaicin.	Capsaicin	70-79	motilin	Canis lupus familiaris	31-38
12358683-7	2002	The effect of intraduodenal capsaicin on motilin-induced gastric contractions was not affected by blockade of nitric oxide synthase, or by beta-adrenoceptor antagonist.	Capsaicin	28-37	motilin	Canis lupus familiaris	41-48
12270633-2	2002	The VR1 receptor is activated not only by capsaicin but also by noxious heat and protons, and therefore it is suggested as a molecular integrator of chemical and physical stimuli that elicit pain.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-7
12270633-5	2002	It has been hypothesized that TG neuronal cell bodies are the source of capsaicin-stimulated release of calcitonin gene-related peptide (CGRP), and hence co-localization experiments were performed.	Capsaicin	72-81	calcitonin related polypeptide alpha	Homo sapiens	104-135
12270633-5	2002	It has been hypothesized that TG neuronal cell bodies are the source of capsaicin-stimulated release of calcitonin gene-related peptide (CGRP), and hence co-localization experiments were performed.	Capsaicin	72-81	calcitonin related polypeptide alpha	Homo sapiens	137-141
12270633-6	2002	Around 10% of the VR1 receptor-ir is expressed on neurons that contain CGRP-ir (ten among 74) in the human TG, indicating that capsaicin may act through the VR1 receptor to modulate the release of CGRP and in turn to modulate pain.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-21
12270633-6	2002	Around 10% of the VR1 receptor-ir is expressed on neurons that contain CGRP-ir (ten among 74) in the human TG, indicating that capsaicin may act through the VR1 receptor to modulate the release of CGRP and in turn to modulate pain.	Capsaicin	127-136	calcitonin related polypeptide alpha	Homo sapiens	71-75
12270633-6	2002	Around 10% of the VR1 receptor-ir is expressed on neurons that contain CGRP-ir (ten among 74) in the human TG, indicating that capsaicin may act through the VR1 receptor to modulate the release of CGRP and in turn to modulate pain.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	157-160
12270633-6	2002	Around 10% of the VR1 receptor-ir is expressed on neurons that contain CGRP-ir (ten among 74) in the human TG, indicating that capsaicin may act through the VR1 receptor to modulate the release of CGRP and in turn to modulate pain.	Capsaicin	127-136	calcitonin related polypeptide alpha	Homo sapiens	197-201
12270633-8	2002	Capsaicin can release nitric oxide, CGRP and substance P from sensory nerves and contribute to central sensitization.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	36-40
12270633-8	2002	Capsaicin can release nitric oxide, CGRP and substance P from sensory nerves and contribute to central sensitization.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	45-56
12231491-8	2002	Furthermore, CCSP-NGF-tg mice developed an increased reactivity of sensory neurons in response to inhaled capsaicin demonstrating NGF-mediated neuronal plasticity.	Capsaicin	106-115	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	13-17
12231491-8	2002	Furthermore, CCSP-NGF-tg mice developed an increased reactivity of sensory neurons in response to inhaled capsaicin demonstrating NGF-mediated neuronal plasticity.	Capsaicin	106-115	nerve growth factor	Mus musculus	18-21
12231491-8	2002	Furthermore, CCSP-NGF-tg mice developed an increased reactivity of sensory neurons in response to inhaled capsaicin demonstrating NGF-mediated neuronal plasticity.	Capsaicin	106-115	nerve growth factor	Mus musculus	130-133
12208893-11	2002	CONCLUSIONS: Vanilloid-induced apoptosis in the parental SCC cells appears to involve the inhibition of mitochondrial respiration.	Capsaicin	13-22	serpin family B member 3	Homo sapiens	57-60
12181172-8	2002	Capsaicin mimicked the effects of GLP-1 and may have reduced the effect of subsequent GLP-1.	Capsaicin	0-9	glucagon	Canis lupus familiaris	34-39
12208893-12	2002	The apoptogenic effects promoted by vanilloid treatment in parental SCC cells, as well as the antiproliferative effects observed in their respiration-deficient clones, suggest that vanilloids may be useful for preventing or treating skin cancers or other hyperproliferative skin disorders.	Capsaicin	36-45	serpin family B member 3	Homo sapiens	68-71
12181172-8	2002	Capsaicin mimicked the effects of GLP-1 and may have reduced the effect of subsequent GLP-1.	Capsaicin	0-9	glucagon	Canis lupus familiaris	86-91
12242509-4	2002	The observed up-regulation of VEGF production by capsaicin was concentration- and duration-dependent and was inversely associated with inhibition of melanoma cell proliferation.	Capsaicin	49-58	vascular endothelial growth factor A	Homo sapiens	30-34
12242509-5	2002	We observed an increase in hypoxia-inducible factor (HIF)-1alpha and VEGF mRNA expression in capsaicin-treated melanoma cells.	Capsaicin	93-102	hypoxia inducible factor 1 subunit alpha	Homo sapiens	27-64
12242509-2	2002	In the present study, we examined the effect of capsaicin on constitutive and induced vascular endothelial cell growth factor (VEGF) expression in malignant melanoma cells.	Capsaicin	48-57	vascular endothelial growth factor A	Homo sapiens	127-131
12242509-3	2002	RESULTS: Capsaicin treatment resulted in enhanced VEGF protein secretion in malignant melanoma cells independent of IL-1beta and TNF-alpha.	Capsaicin	9-18	vascular endothelial growth factor A	Homo sapiens	50-54
12242509-5	2002	We observed an increase in hypoxia-inducible factor (HIF)-1alpha and VEGF mRNA expression in capsaicin-treated melanoma cells.	Capsaicin	93-102	vascular endothelial growth factor A	Homo sapiens	69-73
12242509-6	2002	Further, an electrophoretic mobility shift assay (EMSA) from nuclear extracts from melanoma cells showed a decrease in constitutive activation of NF-kappaB and enhanced HIF-1alpha binding activity to hypoxia response element (HRE) in melanoma cells treated with different concentrations of capsaicin.	Capsaicin	290-299	hypoxia inducible factor 1 subunit alpha	Homo sapiens	169-179
12242509-7	2002	CONCLUSIONS: These data suggest that inhibition of cellular proliferation by capsaicin follows enhanced VEGF production by remaining melanoma cells by enhancing HIF-1alpha expression and binding to HRE.	Capsaicin	77-86	vascular endothelial growth factor A	Homo sapiens	104-108
12242509-7	2002	CONCLUSIONS: These data suggest that inhibition of cellular proliferation by capsaicin follows enhanced VEGF production by remaining melanoma cells by enhancing HIF-1alpha expression and binding to HRE.	Capsaicin	77-86	hypoxia inducible factor 1 subunit alpha	Homo sapiens	161-171
12161756-1	2002	In the urinary bladder, the capsaicin-gated ion channel TRPV1 is expressed both within afferent nerve terminals and within the epithelial cells that line the bladder lumen.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	56-61
12205187-6	2002	The effects of capsaicin (1 microM) were abolished by the VR1 receptor antagonists capsazepine (10 microM) and iodoresiniferatoxin (300 nM).	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-61
12183023-5	2002	After capsaicin treatment, most of the SP and CGRP fibers along the blood vessel walls were eliminated.	Capsaicin	6-15	calcitonin-related polypeptide alpha	Rattus norvegicus	46-50
12243775-3	2002	Capsaicin produced a concentration-dependent increase in intracellular calcium in guinea pig VR1-CHO cells with an estimated EC(50) of 0.17 +/- 0.0065 micro M, similar to that previously reported for rat and human VR1.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	93-96
12243775-3	2002	Capsaicin produced a concentration-dependent increase in intracellular calcium in guinea pig VR1-CHO cells with an estimated EC(50) of 0.17 +/- 0.0065 micro M, similar to that previously reported for rat and human VR1.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	214-217
12243775-5	2002	Capsazepine acted as an antagonist of capsaicin responses in guinea pig VR1-CHO cells (IC(50) of 0.324 +/- 0.041 micro M ), as seen at rat VR1.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	72-75
12169765-5	2002	The content of the sensory neuron marker peptide calcitonin gene-related peptide (CGRP) was reduced after the capsaicin treatment in the hind paw skin by 35-40% and in the dorsal lumbar spinal cord by 48%.	Capsaicin	110-119	calcitonin-related polypeptide alpha	Rattus norvegicus	49-80
12169765-5	2002	The content of the sensory neuron marker peptide calcitonin gene-related peptide (CGRP) was reduced after the capsaicin treatment in the hind paw skin by 35-40% and in the dorsal lumbar spinal cord by 48%.	Capsaicin	110-119	calcitonin-related polypeptide alpha	Rattus norvegicus	82-86
12166946-2	2002	Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety.	Capsaicin	180-193	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-51
12166946-2	2002	Potent activation of the human vanilloid receptor 1 (VR1) was observed for the vanillamides of certain polyfunctional acids from both pools, showing that the vanilloid activity of capsaicinoids can be substantially improved by introducing polar groups and/or unsaturations on the acyl moiety.	Capsaicin	180-193	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-56
12151355-2	2002	In pilot studies, gavage with capsaicin and rotenone elevated the phase II enzymes glutathione S-transferase (GST) and quinone reductase (QR), in the liver and tongue.	Capsaicin	30-39	hematopoietic prostaglandin D synthase	Rattus norvegicus	83-108
12214859-0	2002	Suppression of phorbol ester-induced NF-kappaB activation by capsaicin in cultured human promyelocytic leukemia cells.	Capsaicin	61-70	nuclear factor kappa B subunit 1	Homo sapiens	37-46
12214859-3	2002	Previous studies from this laboratory revealed that capsaicin, when topically applied onto dorsal skin of female ICR mice, strongly attenuated activation of NF-kappaB and AP-1 induced by the typical tumor promoter, 12-O-tetradecanoylphorbol-13-acetate (TPA), which may account for its anti-tumor promoting activity in mouse skin.	Capsaicin	52-61	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	157-166
12214859-4	2002	In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.	Capsaicin	40-49	nuclear factor kappa B subunit 1	Homo sapiens	90-99
12214859-4	2002	In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.	Capsaicin	40-49	NFKB inhibitor alpha	Homo sapiens	122-135
12214859-4	2002	In the present work, we have found that capsaicin suppresses TPA-stimulated activation of NF-kappaB through inhibition of IkappaB alpha degradation and blockade of subsequent nuclear translocation of p65 in human promyelocytic leukemia HL-60 cells.	Capsaicin	40-49	RELA proto-oncogene, NF-kB subunit	Homo sapiens	200-203
12214859-5	2002	Methylation of the phenolic hydroxyl group of capsaicin abolished its inhibitory effect on NF-kappaB DNA binding.	Capsaicin	46-55	nuclear factor kappa B subunit 1	Homo sapiens	91-100
12151355-2	2002	In pilot studies, gavage with capsaicin and rotenone elevated the phase II enzymes glutathione S-transferase (GST) and quinone reductase (QR), in the liver and tongue.	Capsaicin	30-39	hematopoietic prostaglandin D synthase	Rattus norvegicus	110-113
12190936-4	2002	The behavioural response to capsaicin, however, differs from that seen with histamine, raising the possibility that the use of scratch counts as a method of measuring itch severity needs to be set in the context of other responses.	Capsaicin	28-37	itchy, E3 ubiquitin protein ligase	Mus musculus	167-171
12195826-5	2002	Whereas neurokinin A and substance P antagonists, administered alone or together, left the contractile responses to capsaicin unchanged, atropine and tetrodotoxin totally inhibited contraction.	Capsaicin	116-125	tachykinin precursor 1	Homo sapiens	8-20
12570018-8	2002	PEA enhances the VR1-mediated effects of AEA and capsaicin on calcium influx into cells.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-20
12151517-0	2002	Peripheral group II metabotropic glutamate receptors (mGluR2/3) regulate prostaglandin E2-mediated sensitization of capsaicin responses and thermal nociception.	Capsaicin	116-125	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	54-60
12151554-5	2002	Basal and capsaicin-evoked release of calcitonin gene-related peptide (CGRP) was measured in minced spinal tissues taken from naive rats or rats on post-pellet days 1 and 7.	Capsaicin	10-19	calcitonin-related polypeptide alpha	Rattus norvegicus	38-69
12151554-5	2002	Basal and capsaicin-evoked release of calcitonin gene-related peptide (CGRP) was measured in minced spinal tissues taken from naive rats or rats on post-pellet days 1 and 7.	Capsaicin	10-19	calcitonin-related polypeptide alpha	Rattus norvegicus	71-75
12166783-8	2002	Intravenous capsaicin (CAP, 1 mg/kg) or resiniferatoxin (RTX, 1 microg/kg) were used to inhibit afferent neural activity about 30 min before LPS.	Capsaicin	12-21	cyclase associated actin cytoskeleton regulatory protein 1	Rattus norvegicus	23-29
12195826-8	2002	These results suggest that capsaicin relaxes lamb detrusor muscle not through tachykinins but by releasing CGRP from afferent fibres.	Capsaicin	27-36	calcitonin related polypeptide alpha	Homo sapiens	107-111
12160748-7	2002	Animals expressing the mammalian TRPV1 (VR1) channel in ASH nociceptor neurons avoid the TRPV1 ligand capsaicin, allowing selective, drug-inducible activation of a specific behavior.	Capsaicin	102-111	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-38
12113962-4	2002	These results support a role for substance P in the mediation of high, but not low, levels of capsaicin-induced oral irritation.	Capsaicin	94-103	tachykinin precursor 1	Homo sapiens	33-44
12160748-7	2002	Animals expressing the mammalian TRPV1 (VR1) channel in ASH nociceptor neurons avoid the TRPV1 ligand capsaicin, allowing selective, drug-inducible activation of a specific behavior.	Capsaicin	102-111	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-43
12160748-7	2002	Animals expressing the mammalian TRPV1 (VR1) channel in ASH nociceptor neurons avoid the TRPV1 ligand capsaicin, allowing selective, drug-inducible activation of a specific behavior.	Capsaicin	102-111	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
12077604-2	2002	Mammalian TRP channels that are gated by heat and capsaicin (>43 degrees C; TRPV1 (ref.	Capsaicin	50-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	79-84
12077606-1	2002	Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-20
12077606-1	2002	Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-25
12077606-1	2002	Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
12077606-1	2002	Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin.	Capsaicin	227-236	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-20
12077606-1	2002	Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin.	Capsaicin	227-236	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-25
12077606-1	2002	Vanilloid receptor-1 (VR1, also known as TRPV1) is a thermosensitive, nonselective cation channel that is expressed by capsaicin-sensitive sensory afferents and is activated by noxious heat, acidic pH and the alkaloid irritant capsaicin.	Capsaicin	227-236	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
12077606-2	2002	Although VR1 gene disruption results in a loss of capsaicin responses, it has minimal effects on thermal nociception.	Capsaicin	50-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-12
12077606-4	2002	Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as TRPV3), which is heat-sensitive but capsaicin-insensitive.	Capsaicin	160-169	transient receptor potential cation channel subfamily V member 3	Homo sapiens	69-102
12077606-4	2002	Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as TRPV3), which is heat-sensitive but capsaicin-insensitive.	Capsaicin	160-169	transient receptor potential cation channel subfamily V member 3	Homo sapiens	104-108
12077606-4	2002	Here we identify a member of the vanilloid receptor/TRP gene family, vanilloid receptor-like protein 3 (VRL3, also known as TRPV3), which is heat-sensitive but capsaicin-insensitive.	Capsaicin	160-169	transient receptor potential cation channel subfamily V member 3	Homo sapiens	124-129
12109845-10	2002	The expression of VR1 is plastic and down-regulated during vanilloid therapy, which might have a pivotal role in desensitization.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-21
12091579-2	2002	It has been suggested that the capsaicin receptor (VR1), a nociceptor-specific cation channel sensitive to noxious heat, protons, and capsaicin, is a channel that is modified by BK in these effects.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-54
12169105-4	2002	SP(1-7) and capsaicin each increased NK-1 receptor mRNA in the spinal cord (6 h) followed by an increase in NK-1 receptor-immunoreactivity (24 h and 1 week).	Capsaicin	12-21	tachykinin receptor 1	Rattus norvegicus	37-50
12169105-4	2002	SP(1-7) and capsaicin each increased NK-1 receptor mRNA in the spinal cord (6 h) followed by an increase in NK-1 receptor-immunoreactivity (24 h and 1 week).	Capsaicin	12-21	tachykinin receptor 1	Rattus norvegicus	108-121
12169105-6	2002	Instead, D-SP(1-7) prevented the upregulation of NK-1 receptor immunoreactivity that was induced by capsaicin injected intrathecally, suggesting that the effect of capsaicin is also mediated by SP N-terminal metabolites.	Capsaicin	100-109	tachykinin receptor 1	Rattus norvegicus	49-62
12169105-6	2002	Instead, D-SP(1-7) prevented the upregulation of NK-1 receptor immunoreactivity that was induced by capsaicin injected intrathecally, suggesting that the effect of capsaicin is also mediated by SP N-terminal metabolites.	Capsaicin	164-173	tachykinin receptor 1	Rattus norvegicus	49-62
12110967-3	2002	Microinjections (1 microl) of histamine, serotonin (5-HT), nicotine, capsaicin, or formalin each elicited similar distributions of Fos-like immunoreactivity (FLI) in laminae I-II of the ipsilateral superficial dorsal horn, with little or no FLI in deeper laminae or contralaterally.	Capsaicin	69-78	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	131-134
12091579-2	2002	It has been suggested that the capsaicin receptor (VR1), a nociceptor-specific cation channel sensitive to noxious heat, protons, and capsaicin, is a channel that is modified by BK in these effects.	Capsaicin	31-40	kininogen 1	Homo sapiens	178-180
12091579-6	2002	We also demonstrated that in capsaicin-sensitive dorsal root ganglion (DRG) neurons the activation threshold of heat-induced current, which is considered to be VR-1 mediated, was lowered by BK and that this effect was also mediated by PKC.	Capsaicin	29-38	kininogen 1	Homo sapiens	190-192
12098622-0	2002	Activation of protein kinase C sensitizes human VR1 to capsaicin and to moderate decreases in pH at physiological temperatures in Xenopus oocytes.	Capsaicin	55-64	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-51
12034083-10	2002	In the capsaicin group, the immunohistochemical stain of SP and EGF/EGFR was faint and without obvious change during the wound healing process.	Capsaicin	7-16	epidermal growth factor like 1	Rattus norvegicus	64-67
12106807-5	2002	The PAR-2-mediated suppression of acid secretion was resistant to cyclooxygenase inhibition or ablation of sensory neurons by capsaicin.	Capsaicin	126-135	F2R like trypsin receptor 1	Rattus norvegicus	4-9
12044642-0	2002	Chronotropic response of beta-adrenergic-, muscarinic-, and calcitonin gene-related peptide-receptor agonists in right atria from neonatal capsaicin-treated rats.	Capsaicin	139-148	calcitonin-related polypeptide alpha	Rattus norvegicus	60-91
12044642-8	2002	The neonatal capsaicin treatment reduced by about 74% the CGRP content in the heart in all groups.	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	58-62
12060783-0	2002	An endogenous capsaicin-like substance with high potency at recombinant and native vanilloid VR1 receptors.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-96
12060783-2	2002	VR1 is gated by protons, heat, and the pungent ingredient of "hot" chili peppers, capsaicin.	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-3
12060783-10	2002	Our data demonstrate the existence of a brain substance similar to capsaicin not only with respect to its chemical structure but also to its potency at VR1 receptors.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	152-155
12034083-10	2002	In the capsaicin group, the immunohistochemical stain of SP and EGF/EGFR was faint and without obvious change during the wound healing process.	Capsaicin	7-16	epidermal growth factor receptor	Rattus norvegicus	68-72
12019337-8	2002	In addition, spinal CaMK II activity enhances phosphorylation of AMPA receptor GluR1 subunits during central sensitization produced by capsaicin injection.	Capsaicin	135-144	glutamate ionotropic receptor AMPA type subunit 1	Rattus norvegicus	79-84
12110114-0	2002	5-Hydroxytryptamine(1B/1D) and 5-hydroxytryptamine1F receptors inhibit capsaicin-induced c-fos immunoreactivity within mouse trigeminal nucleus caudalis.	Capsaicin	71-80	FBJ osteosarcoma oncogene	Mus musculus	89-94
12110114-1	2002	In order to investigate the c-fos response within the trigeminal nucleus caudalis (Sp5C) after noxious meningeal stimulation, capsaicin (0.25, 0.5, 1 and 5 nmol) was administered intracisternally in urethane (1 g/kg) and alpha-chloralose (20 mg/kg) anaesthetized male mice.	Capsaicin	126-135	FBJ osteosarcoma oncogene	Mus musculus	28-33
12110114-2	2002	Capsaicin induced a robust and dose-dependent c-fos-like immunoreactivity (c-fos LI) within Sp5C.	Capsaicin	0-9	FBJ osteosarcoma oncogene	Mus musculus	46-51
12110114-2	2002	Capsaicin induced a robust and dose-dependent c-fos-like immunoreactivity (c-fos LI) within Sp5C.	Capsaicin	0-9	FBJ osteosarcoma oncogene	Mus musculus	75-80
12040079-0	2002	Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism.	Capsaicin	53-62	cannabinoid receptor 1 (brain)	Mus musculus	94-97
12040079-0	2002	Delta 9-tetrahydrocannabinol and cannabinol activate capsaicin-sensitive sensory nerves via a CB1 and CB2 cannabinoid receptor-independent mechanism.	Capsaicin	53-62	cannabinoid receptor 2 (macrophage)	Mus musculus	102-105
14622772-0	2002	The role of nitric oxide in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein in the spinal cord after intradermal injection of capsaicin.	Capsaicin	167-176	cAMP responsive element binding protein 1	Homo sapiens	51-116
14622772-1	2002	We investigated the involvement of nitric oxide (NO) in the phosphorylation of cyclic adenosine monophosphate-responsive element-binding protein (CREB) in the spinal cord of rats during central sensitization after intradermal capsaicin injection.	Capsaicin	226-235	cAMP responsive element binding protein 1	Rattus norvegicus	146-150
14622772-3	2002	The level of p-CREB increased by 20 minutes, peaked between 20 and 60 minutes after capsaicin injection, and started to decrease after 150 minutes.	Capsaicin	84-93	cAMP responsive element binding protein 1	Homo sapiens	15-19
14622772-5	2002	The p-CREB expression on the ipsilateral side of the spinal dorsal horn, but not on the contralateral side, increased significantly after capsaicin injection.	Capsaicin	138-147	cAMP responsive element binding protein 1	Homo sapiens	6-10
14622772-6	2002	The increase in p-CREB induced by capsaicin injection was partially blocked by pretreatment with N(G)-nitro-L-arginine methyl ester (L-NAME), an NO synthase inhibitor, administered through a microdialysis fiber placed across the spinal cord.	Capsaicin	34-43	cAMP responsive element binding protein 1	Homo sapiens	18-22
11992116-1	2002	The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for the burning sensation elicited by capsaicin.	Capsaicin	117-126	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-24
11992116-1	2002	The vanilloid receptor-1 (VR1) is a heat-gated ion channel that is responsible for the burning sensation elicited by capsaicin.	Capsaicin	117-126	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-29
11992116-5	2002	Ethanol potentiated the response of VR1 to capsaicin, protons and heat and lowered the threshold for heat activation of VR1 from approximately 42 degrees C to approximately 34 degrees C. This provides a likely mechanistic explanation for the ethanol-induced sensory responses that occur at body temperature and for the sensitivity of inflamed tissues to ethanol, such as might be found in esophagitis, neuralgia or wounds.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-39
12069907-0	2002	The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	47-78
12069907-0	2002	The effect of cannabinoids on capsaicin-evoked calcitonin gene-related peptide (CGRP) release from the isolated paw skin of diabetic and non-diabetic rats.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
12069907-4	2002	We investigated the effect of cannabinoid on capsaicin-evoked release of calcitonin gene-related peptide (CGRP) from the rat paw skin in vitro, comparing non-diabetic and streptozotocin-induced diabetic animals.	Capsaicin	45-54	calcitonin-related polypeptide alpha	Rattus norvegicus	73-104
12069907-4	2002	We investigated the effect of cannabinoid on capsaicin-evoked release of calcitonin gene-related peptide (CGRP) from the rat paw skin in vitro, comparing non-diabetic and streptozotocin-induced diabetic animals.	Capsaicin	45-54	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
12069907-5	2002	Diabetes caused a greater than two-fold increase in basal and capsaicin-evoked CGRP release.	Capsaicin	62-71	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
12069907-6	2002	The synthetic CB(1)/CB(2) receptor agonist, CP55940 (100 nM), inhibited capsaicin-evoked CGRP release in both non-diabetic (30.92+/-7.69%, P<0.05) and diabetic animals (37.82+/-9.85%, P<0.05).	Capsaicin	72-81	cannabinoid receptor 2	Rattus norvegicus	20-34
12069907-6	2002	The synthetic CB(1)/CB(2) receptor agonist, CP55940 (100 nM), inhibited capsaicin-evoked CGRP release in both non-diabetic (30.92+/-7.69%, P<0.05) and diabetic animals (37.82+/-9.85%, P<0.05).	Capsaicin	72-81	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
12069907-8	2002	The endogenous cannabinoid, anandamide (100 nM) inhibited capsaicin-evoked CGRP release in non-diabetic animals (28.88+/-7.12%, P<0.05) but neither the CB(1) nor the CB(2) receptor antagonist attenuated this action of anandamide.	Capsaicin	58-67	calcitonin-related polypeptide alpha	Rattus norvegicus	75-79
12069907-8	2002	The endogenous cannabinoid, anandamide (100 nM) inhibited capsaicin-evoked CGRP release in non-diabetic animals (28.88+/-7.12%, P<0.05) but neither the CB(1) nor the CB(2) receptor antagonist attenuated this action of anandamide.	Capsaicin	58-67	cannabinoid receptor 2	Rattus norvegicus	169-183
11994487-3	2002	We report in this work that TNF-alpha increases the susceptibility of sensory neurons to dinitrobenzene sulfonic acid (DNS) and capsaicin, leading to a tracheal vascular hyperpermeability response in DNFB-sensitized and DNS-challenged mice.	Capsaicin	128-137	tumor necrosis factor	Mus musculus	28-37
12065069-3	2002	Calcitonin gene-related peptide (CGRP), a major transmitter of capsaicin-sensitive sensory nerves, has recently been shown to play an important role in mediation of the preconditioning induced by brief ischemia or hyperthermia or by some drugs, and alpha-CGRP seems to play a major role in the mediation of delayed preconditioning.	Capsaicin	63-72	calcitonin related polypeptide alpha	Homo sapiens	0-31
12065069-3	2002	Calcitonin gene-related peptide (CGRP), a major transmitter of capsaicin-sensitive sensory nerves, has recently been shown to play an important role in mediation of the preconditioning induced by brief ischemia or hyperthermia or by some drugs, and alpha-CGRP seems to play a major role in the mediation of delayed preconditioning.	Capsaicin	63-72	calcitonin related polypeptide alpha	Homo sapiens	33-37
12112942-4	2002	METHODS: Male Wistar rats were treated with capsaicin (50 mg/kg) at 1-3 days of age to ablate the CGRP-containing neurons.	Capsaicin	44-53	calcitonin-related polypeptide alpha	Rattus norvegicus	98-102
12054538-3	2002	Further analysis revealed that thapsigargin is a mixed-type inhibitor, suggesting both direct and indirect interactions between thapsigargin and the capsaicin binding site of VR1.	Capsaicin	149-158	transient receptor potential cation channel subfamily V member 1	Homo sapiens	175-178
12398159-5	2002	Capsaicin decreased PD and reaction to mechanical stimulation in trachea incubated in Ringer solution supplemented with amiloride.	Capsaicin	0-9	dachs	Drosophila melanogaster	20-22
12138252-2	2002	After topical application of capsaicin (1%) to the sciatic nerve, FOS-like immunoreactive (FOS-LI) neurons were observed, chiefly in the superficial laminae of the lumbar dorsal horn.	Capsaicin	29-38	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
11985550-2	2002	Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection.	Capsaicin	49-58	F2R like trypsin receptor 1	Homo sapiens	0-29
12007523-1	2002	Very recently, a membrane receptor (vanilloid receptor type 1 [VR-1]) sensitive to capsaicin or resiniferatoxin (RTX) was identified in small- and medium-sized dorsal root ganglion neurons that give rise to most unmyelinated sensory fibers.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-67
12007523-2	2002	After vanilloid binding to VR-1, these neurons remain transiently desensitized; that is, less reactive to natural stimuli.	Capsaicin	6-15	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-31
11884385-2	2002	It has been reported that ATP, one of the inflammatory mediators, potentiates the VR1 currents evoked by capsaicin or protons and reduces the temperature threshold for activation of VR1 through metabotropic P2Y(1) receptors in a protein Kinase C (PKC)-dependent pathway, suggesting the phosphorylation of VR1 by PKC.	Capsaicin	105-114	vault RNA 1-1	Homo sapiens	82-85
11884385-2	2002	It has been reported that ATP, one of the inflammatory mediators, potentiates the VR1 currents evoked by capsaicin or protons and reduces the temperature threshold for activation of VR1 through metabotropic P2Y(1) receptors in a protein Kinase C (PKC)-dependent pathway, suggesting the phosphorylation of VR1 by PKC.	Capsaicin	105-114	protein kinase C epsilon	Homo sapiens	247-250
11884385-2	2002	It has been reported that ATP, one of the inflammatory mediators, potentiates the VR1 currents evoked by capsaicin or protons and reduces the temperature threshold for activation of VR1 through metabotropic P2Y(1) receptors in a protein Kinase C (PKC)-dependent pathway, suggesting the phosphorylation of VR1 by PKC.	Capsaicin	105-114	protein kinase C epsilon	Homo sapiens	312-315
12043933-10	2002	Serum substance P levels increased after initiation of topical capsaicin treatment (72.9+/-5.8 pg/ml vs. 81.7+/-5.0 pg/ml; p<0.05), but returned to baseline levels during further treatment (77.4+/-8.3 pg/ml: n.s.).	Capsaicin	63-72	tachykinin precursor 1	Homo sapiens	6-17
11985550-2	2002	Protease-activated receptor 2 (PAR2), present in capsaicin-sensitive sensory neurons, induces gastric mucus secretion and mucosal cytoprotection.	Capsaicin	49-58	F2R like trypsin receptor 1	Homo sapiens	31-35
12034025-6	2002	Further, downregulation of IL-8 expression in capsaicin-treated melanoma cells resulted in inhibition of in vitro cell proliferation.	Capsaicin	46-55	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
11973003-11	2002	The magnitude of capsaicin-induced increase of paw thickness was reduced by approximately 50% from 31+/-1.34% (n=6) to 15+/-1.63% (n=8; P<0.05) by nociceptin (10 micromol).	Capsaicin	17-26	prepronociceptin	Rattus norvegicus	150-160
12074098-22	2002	The ulcer healing and the GBF effects of melatonin and L-tryptophan were significantly impaired in rats with capsaicin-induced denervation of sensory nerves and both, ulcer healing and the hyperemia at ulcer margin were restored in these rats by addition of exogenous CGRP to melatonin and L-tryptophan.	Capsaicin	109-118	calcitonin-related polypeptide alpha	Rattus norvegicus	268-272
11973003-10	2002	Finally, in order to explore the physiological significance of such modulation in a fully integrated system, we evaluated the effect of intrathecally administered nociceptin on capsaicin-induced acute cutaneous neurogenic inflammation in rat hind paw, quantified by examining the degree of paw edema in anesthetized rats.	Capsaicin	177-186	prepronociceptin	Rattus norvegicus	163-173
12024109-1	2002	Capsaicin-sensitive sensory neurons are nociceptive neurons that release calcitonin gene-related peptide (CGRP) on activation by various noxious stimuli.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	73-104
12024109-1	2002	Capsaicin-sensitive sensory neurons are nociceptive neurons that release calcitonin gene-related peptide (CGRP) on activation by various noxious stimuli.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
12024109-7	2002	Administration of capsaicin and CGRP significantly enhanced I/R-induced increases in hepatic levels of 6-keto-PGF(1alpha), increased hepatic-tissue blood flow after reperfusion, and inhibited the I/R-induced increase in tissue levels of both tumor necrosis factor-alpha (TNF-alpha) and myeloperoxidase.	Capsaicin	18-27	tumor necrosis factor	Rattus norvegicus	242-269
12024109-7	2002	Administration of capsaicin and CGRP significantly enhanced I/R-induced increases in hepatic levels of 6-keto-PGF(1alpha), increased hepatic-tissue blood flow after reperfusion, and inhibited the I/R-induced increase in tissue levels of both tumor necrosis factor-alpha (TNF-alpha) and myeloperoxidase.	Capsaicin	18-27	tumor necrosis factor	Rattus norvegicus	271-280
12024109-7	2002	Administration of capsaicin and CGRP significantly enhanced I/R-induced increases in hepatic levels of 6-keto-PGF(1alpha), increased hepatic-tissue blood flow after reperfusion, and inhibited the I/R-induced increase in tissue levels of both tumor necrosis factor-alpha (TNF-alpha) and myeloperoxidase.	Capsaicin	18-27	myeloperoxidase	Rattus norvegicus	286-301
12034025-0	2002	Regulation of constitutive and induced NF-kappaB activation in malignant melanoma cells by capsaicin modulates interleukin-8 production and cell proliferation.	Capsaicin	91-100	C-X-C motif chemokine ligand 8	Homo sapiens	111-124
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	12-21	interleukin 1 beta	Homo sapiens	144-152
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	12-21	tumor necrosis factor	Homo sapiens	165-174
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	12-21	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	23-55	interleukin 1 beta	Homo sapiens	144-152
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	23-55	tumor necrosis factor	Homo sapiens	165-174
12034025-2	2002	Addition of capsaicin (8-methyl-N-vanillyl-6-nonenamide), a known inhibitor of NF-kappaB, resulted in the inhibition of constitutive as well as IL-1beta-induced and TNF-alpha-induced IL-8 expression in melanoma cells.	Capsaicin	23-55	C-X-C motif chemokine ligand 8	Homo sapiens	183-187
12034025-3	2002	The inhibition of IL-8 expression was dependent on the concentration of capsaicin and duration of treatment.	Capsaicin	72-81	C-X-C motif chemokine ligand 8	Homo sapiens	18-22
12034025-5	2002	Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.	Capsaicin	33-42	interleukin 1 beta	Homo sapiens	84-92
12034025-5	2002	Treatment of melanoma cells with capsaicin inhibited activation of constitutive and IL-1beta-induced NF-kappaB, but not AP-1, leading to inhibition of IL-8 expression.	Capsaicin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	151-155
11978404-1	2002	Activation of cutaneous C-fibers by capsaicin or sciatic nerve transection increases the number of astrocytic gap junctions as well as the levels of connexin 43 in the dorsal horn on the stimulated side.	Capsaicin	36-45	gap junction protein, alpha 1	Rattus norvegicus	149-160
11931994-4	2002	However, VR1 remains the only channel activated by vanilloids such as capsaicin.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-12
11937102-4	2002	Nitroglycerin (3 x 10(-9)-10(-6) M) caused a concentration-dependent relaxation in the isolated rat thoracic aorta, an effect that was reduced by CGRP-(8-37) (3 x 10(-7) M) or capsaicin (3 x 10(-7) M).	Capsaicin	176-185	calcitonin-related polypeptide alpha	Rattus norvegicus	146-150
11989832-0	2002	Capsaicin-sensitive nerve fibres induce epithelial cell proliferation, inflammatory cell immigration and transforming growth factor-alpha expression in the rat colonic mucosa in vivo.	Capsaicin	0-9	transforming growth factor alpha	Rattus norvegicus	105-137
11989832-2	2002	The aim of our study was to evaluate the effects of capsaicin-sensitive nerve fibres in rat colonic mucosa on epithelial cell proliferation and transforming growth factor-alpha (TGFalpha) expression, which is important in mucosal defence, protection and repair.	Capsaicin	52-61	transforming growth factor alpha	Rattus norvegicus	144-176
11989832-2	2002	The aim of our study was to evaluate the effects of capsaicin-sensitive nerve fibres in rat colonic mucosa on epithelial cell proliferation and transforming growth factor-alpha (TGFalpha) expression, which is important in mucosal defence, protection and repair.	Capsaicin	52-61	transforming growth factor alpha	Rattus norvegicus	178-186
11989832-10	2002	A 2-fold increase of TGFalpha mRNA and a 10-fold increase of TGFalpha protein expression were obtained 2-12 h after capsaicin enemas.	Capsaicin	116-125	transforming growth factor alpha	Rattus norvegicus	21-29
11989832-10	2002	A 2-fold increase of TGFalpha mRNA and a 10-fold increase of TGFalpha protein expression were obtained 2-12 h after capsaicin enemas.	Capsaicin	116-125	transforming growth factor alpha	Rattus norvegicus	61-69
11989832-12	2002	CONCLUSION: Capsaicin-sensitive nerve fibres modulate epithelial cell proliferation and TGFalpha expression in colonic mucosa as well as a migration of inflammatory cells into the colonic mucosa.	Capsaicin	12-21	transforming growth factor alpha	Rattus norvegicus	88-96
11937096-4	2002	We found here that vanilloid VR1 receptor agonists (capsaicin and N-N"-(3-methoxy-4-aminoethoxy-benzyl)-(4-tert-butyl-benzyl)-urea [SDZ-249-665]) exhibit a small, albeit significant, inhibition of spasticity that can be attenuated by the vanilloid VR1 receptor antagonist, capsazepine.	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-32
12418083-1	2002	Capsaicin (50 mg kg-1) or vehicle (control) was injected into 2-day-old mice, and apoptotic cell death of the lumbar dorsal root ganglion (DRG) cells was examined using in situ terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method at 5, 24, 48 and 72 h after treatment.	Capsaicin	0-9	deoxynucleotidyltransferase, terminal	Mus musculus	216-219
11879797-10	2002	Intrathecal pretreatment 48--72 h prior to the experiment with capsaicin at doses sufficient to cause a 50% depletion of dorsal horn CGRP, caused a total blockade of the mechanical allodynia indicating an involvement of peptidergic fine afferent fibers.	Capsaicin	63-72	calcitonin-related polypeptide alpha	Rattus norvegicus	133-137
12418083-1	2002	Capsaicin (50 mg kg-1) or vehicle (control) was injected into 2-day-old mice, and apoptotic cell death of the lumbar dorsal root ganglion (DRG) cells was examined using in situ terminal deoxynucleotidyl transferase (TdT)-mediated dUTP-biotin nick end labeling (TUNEL) method at 5, 24, 48 and 72 h after treatment.	Capsaicin	0-9	deoxynucleotidyltransferase, terminal	Mus musculus	177-214
11930156-0	2002	HSP90 inhibitors alter capsaicin- and ATP-induced currents in rat dorsal root ganglion neurons.	Capsaicin	23-32	heat shock protein 90 alpha family class A member 1	Rattus norvegicus	0-5
11930156-4	2002	P2X and VR1 are membrane receptors activated by ATP and capsaicin, respectively, and are thought to be involved in inflammation-related nociception.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	8-11
11888291-6	2002	The activities are inhibited completely by capsaicin, which represents a defining characteristic of tNOX activity.	Capsaicin	43-52	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	100-104
11888291-7	2002	Functional motifs identified by site-directed mutagenesis within the C-terminal portion of the tNOX protein corresponding to the processed plasma membrane-associated form include quinone (capsaicin), copper and adenine nucleotide binding domains, and two cysteines essential for catalytic activity.	Capsaicin	188-197	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	95-99
11877338-10	2002	The PAR-2-mediated gastric pepsin secretion was resistant to omeprazole, N(G)-nitro-L-arginine methyl ester (L-NAME) or atropine, and also to ablation of sensory neurons by capsaicin.	Capsaicin	173-182	F2R like trypsin receptor 1	Rattus norvegicus	4-9
12005045-5	2002	The growth abilities of the strains with the deletion of the induced genes suggest that capsaicin is pumped out of the yeast cells by the PDR5 transporter.	Capsaicin	88-97	ATP-binding cassette multidrug transporter PDR5	Saccharomyces cerevisiae S288C	138-142
11861807-1	2002	Arvanil, a structural "hybrid" between the endogenous cannabinoid CB1 receptor ligand anandamide and capsaicin, is a potent agonist for the capsaicin receptor VR1 (vanilloid receptor type 1), inhibits the anandamide membrane transporter (AMT), and induces cannabimimetic responses in mice.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	159-162
11906962-3	2002	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP), which seems to be the predominant neurotransmitter of spinal afferents in the rat stomach, exerting many pharmacological effects by a direct mechanism or indirectly through second messengers such as nitric oxide (NO).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	65-96
11906962-3	2002	Capsaicin stimulates afferent nerves and enhances the release of calcitonin gene-related peptide (CGRP), which seems to be the predominant neurotransmitter of spinal afferents in the rat stomach, exerting many pharmacological effects by a direct mechanism or indirectly through second messengers such as nitric oxide (NO).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	98-102
11906962-9	2002	We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively.	Capsaicin	160-169	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-140
11906962-9	2002	We determined CGRP and NO release from rat stomach and specific [(3)H]-resiniferatoxin (RTX) binding to gastric vanilloid receptor subtype 1 (VR1), which binds capsaicin, using EIA, a microdialysis system and a radioreceptor assay, respectively.	Capsaicin	160-169	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	142-145
11861322-0	2002	Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.	Capsaicin	21-30	prepronociceptin	Homo sapiens	0-11
11939719-21	2002	Capsaicin deactivation of SN oradministration of CGRP 8-37 abolished above beneficial effects of leptin on CIP, whereas melatonin-induced protection of pancreas was unaffected.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	49-53
11829471-1	2002	Vanilloid receptor subtype 1, VR1, is an ion channel that serves as a polymodal detector of pain-producing chemicals such as capsaicin and protons in primary afferent neurons.	Capsaicin	125-134	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-28
11829471-1	2002	Vanilloid receptor subtype 1, VR1, is an ion channel that serves as a polymodal detector of pain-producing chemicals such as capsaicin and protons in primary afferent neurons.	Capsaicin	125-134	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-33
11829471-3	2002	The capsaicin- and acidification-evoked increases in [Ca(2+)](i) were inhibited by capsazepine, an antagonist to VR1.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-116
11829471-5	2002	These findings suggest that functional VR1-like protein is present and functions as a sensor against noxious chemical stimuli, such as capsaicin or acidification, in epidermal keratinocytes.	Capsaicin	135-144	transient receptor potential cation channel subfamily V member 1	Homo sapiens	39-42
11882676-4	2002	The absence of T-type I(Ca) is highly correlated with sensitivity to mu-opioid agonists and the VR1 agonist capsaicin.	Capsaicin	108-117	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	96-99
11861322-0	2002	Orphanin FQ inhibits capsaicin-induced thermal nociception in monkeys by activation of peripheral ORL1 receptors.	Capsaicin	21-30	opioid related nociceptin receptor 1	Homo sapiens	98-102
11861322-10	2002	Co-administration of OFQ (1--30 microg) with capsaicin in the tail dose-dependently inhibited thermal nociception.	Capsaicin	45-54	prepronociceptin	Homo sapiens	21-24
12052051-7	2002	However, to date the only reasonably well characterized, non-cannabinoid site of action for AEA is the vanilloid receptor type 1 (VR1), a non-selective cation channel gated also by capsaicin, protons and heat.	Capsaicin	181-190	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	103-133
11858952-6	2002	Intradermal injections of capsaicin prior to UVB-irradiation inhibited the UVB-induced CGRP expression, BrdU labeling in basal keratinocytes and epidermal thickening.	Capsaicin	26-35	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	87-91
11786475-0	2002	CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord.	Capsaicin	46-55	cannabinoid receptor 1 (brain)	Mus musculus	0-5
11790377-3	2002	ReN 1869 at 0.01-10 mg/kg is antinociceptive in tests of chemical nociception in rodents (formalin, capsaicin, phenyl quinone writhing) but not in thermal tests (hot plate and tail flick).	Capsaicin	100-109	renin 1 structural	Mus musculus	0-3
11738242-5	2002	The cardioprotection as well as the synthesis and release of CGRP induced by MLA were completely abolished by pretreatment with zinc protoporphrin IX (ZnPP-9), an inhibitor of HO-1, or by capsaicin (50 mg/kg, s.c.), which selectively depletes transmitters in capsaicin-sensitive sensory nerves.	Capsaicin	188-197	calcitonin-related polypeptide alpha	Rattus norvegicus	61-65
11738242-5	2002	The cardioprotection as well as the synthesis and release of CGRP induced by MLA were completely abolished by pretreatment with zinc protoporphrin IX (ZnPP-9), an inhibitor of HO-1, or by capsaicin (50 mg/kg, s.c.), which selectively depletes transmitters in capsaicin-sensitive sensory nerves.	Capsaicin	259-268	calcitonin-related polypeptide alpha	Rattus norvegicus	61-65
11815370-7	2002	The CGRP receptor antagonist CGRP(8 - 37) (400 nmol kg(-1)) had no effect on capsaicin-induced blood flow in NK(1)+/+mice but abolished the increased blood flow to capsaicin in NK(1)-/-, and NK(1)+/+wild-type mice pre-treated with SR140333.	Capsaicin	164-173	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	4-8
11815370-7	2002	The CGRP receptor antagonist CGRP(8 - 37) (400 nmol kg(-1)) had no effect on capsaicin-induced blood flow in NK(1)+/+mice but abolished the increased blood flow to capsaicin in NK(1)-/-, and NK(1)+/+wild-type mice pre-treated with SR140333.	Capsaicin	164-173	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	29-33
11815370-9	2002	The capsaicin-induced increased blood flow involves activation of, and possible interactions between, both NK(1) and CGRP(1) receptors.	Capsaicin	4-13	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	117-121
11874552-6	2002	Subdiaphragmatic vagotomy or afferent ablation by intraluminal treatment with capsaicin diminished RMCP II concentration in basal conditions and significantly reduced the response to OVH, which in control animals induced a three-fold increase of the protease.	Capsaicin	78-87	mast cell protease 2	Rattus norvegicus	99-106
11786475-0	2002	CB(1) receptor antagonist SR141716A increases capsaicin-evoked release of Substance P from the adult mouse spinal cord.	Capsaicin	46-55	tachykinin 1	Mus musculus	74-85
11786475-2	2002	We have investigated a possible modulatory role for Type 1 Cannabinoid receptors (CB(1)) on the release of excitatory transmitter Substance P from the adult mouse spinal cord after stimulation of nociceptor terminals by capsaicin.	Capsaicin	220-229	cannabinoid receptor 1 (brain)	Mus musculus	82-87
11786475-2	2002	We have investigated a possible modulatory role for Type 1 Cannabinoid receptors (CB(1)) on the release of excitatory transmitter Substance P from the adult mouse spinal cord after stimulation of nociceptor terminals by capsaicin.	Capsaicin	220-229	tachykinin 1	Mus musculus	130-141
11786475-6	2002	Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM).	Capsaicin	86-95	cannabinoid receptor 1 (brain)	Mus musculus	15-20
11786475-6	2002	Superfusion of CB(1) antagonist SR141716A (5 microM) increased evoked SP release with capsaicin (0.1 - 10 microM) and reversed the reducing effect of high dose capsaicin (100 microM).	Capsaicin	160-169	cannabinoid receptor 1 (brain)	Mus musculus	15-20
11786475-7	2002	Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation.	Capsaicin	56-65	cannabinoid receptor 1 (brain)	Mus musculus	14-19
11786475-7	2002	Antagonism of CB(1) receptors in the spinal cord during capsaicin stimulation, is evidence of tonic CB(1) activity inhibiting the release of excitatory transmitters after activation of nociceptive neurones and is also indicative of endocannabinoid production during noxious stimulation.	Capsaicin	56-65	cannabinoid receptor 1 (brain)	Mus musculus	100-105
11752091-6	2002	The data demonstrate that VR1 receptor agonists capsaicin and resiniferatoxin lead to a sustained increase in intracellular calcium and sodium in a concentration-dependent manner, followed by cell death.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-29
12086397-6	2002	Pretreatment with NS-398, a selective COX-2 inhibitor, or indomethacin, a nonselective COX inhibitor, significantly enhanced the Cap-induced decreased cell viability and apoptosis.	Capsaicin	129-132	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	38-43
12031340-1	2002	The vanilloid receptor subtype 1 (VR1) is expressed in a sub-population of small dorsal root ganglion (DRG) neurones in mammals and serves as the common transducer of the pain-producing signals, such as noxious heat, acids and capsaicin [Caterina et al., Nature 389 (1997) 816-824; Tominaga et al., Neuron 21 (1998) 531-543].	Capsaicin	227-236	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-32
12031340-1	2002	The vanilloid receptor subtype 1 (VR1) is expressed in a sub-population of small dorsal root ganglion (DRG) neurones in mammals and serves as the common transducer of the pain-producing signals, such as noxious heat, acids and capsaicin [Caterina et al., Nature 389 (1997) 816-824; Tominaga et al., Neuron 21 (1998) 531-543].	Capsaicin	227-236	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-37
11927161-1	2002	Previous findings have shown that the capsaicin sensitivity of sensory fibres is due to the expression of a specific membrane protein, the vanilloid receptor type 1 (VR1).	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	139-169
12031340-3	2002	Here we report that dithiothreitol (DTT) (2-60 mM), an agent that maintains -SH groups of cysteines in a reduced state, greatly facilitates membrane currents induced by noxious heat or capsaicin (1 microM) in cultured DRG neurones from the rat and in VR1-transfected HEK293 cells.	Capsaicin	185-194	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	251-254
11804333-8	2001	We found that six of them significantly enhanced the inward current that is induced by capsaicin with the following order of potency: Rc > Rf > Rg1 approximately Rd > Rb2 > Rb1.	Capsaicin	87-96	retinoblastoma-like 2 L homeolog	Xenopus laevis	176-179
12435416-0	2002	Role of protein kinase A in phosphorylation of NMDA receptor 1 subunits in dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats.	Capsaicin	150-159	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	8-24
12435416-3	2002	We have recently reported that there is enhanced phosphorylation of NR1 on serine 897 in dorsal horn and spinothalamic tract (STT) neurons after intradermal injection of capsaicin (CAP) in rats [Zou et al.	Capsaicin	170-179	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	68-71
12435416-3	2002	We have recently reported that there is enhanced phosphorylation of NR1 on serine 897 in dorsal horn and spinothalamic tract (STT) neurons after intradermal injection of capsaicin (CAP) in rats [Zou et al.	Capsaicin	181-184	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	68-71
12435419-1	2002	Capsaicin acting on the vanilloid type 1 receptor (VR1) excites a subset of primary sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-49
12435419-1	2002	Capsaicin acting on the vanilloid type 1 receptor (VR1) excites a subset of primary sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-54
12182898-1	2002	Capsaicin acts on the vanilloid receptor subtype 1, a noxious heat-gated cation channel located on a major subgroup of nociceptive primary afferent neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-50
12182898-6	2002	Daily treatment with nerve growth factor (NGF, 10 x 100 microg/kg s.c.), started 1 day after capsaicin injection, prevented the loss of B-type cells but did not counteract the development of long-lasting mitochondrial damage.	Capsaicin	93-102	nerve growth factor	Rattus norvegicus	21-40
12182898-6	2002	Daily treatment with nerve growth factor (NGF, 10 x 100 microg/kg s.c.), started 1 day after capsaicin injection, prevented the loss of B-type cells but did not counteract the development of long-lasting mitochondrial damage.	Capsaicin	93-102	nerve growth factor	Rattus norvegicus	42-45
12182898-7	2002	After NGF treatment, partial restitution of chemonociception to capsaicin instillation into the eye occurred but capsaicin-induced inhibition of neurogenic plasma extravasation in the hindpaw evoked by topical application of mustard oil remained unaltered.	Capsaicin	113-122	nerve growth factor	Rattus norvegicus	6-9
11843868-6	2001	In addition, the ventrolateral periaqueductal grey, the intralaminar thalamic and various hypothalamic areas, showed an enhanced Fos expression after the intracisternal administration of capsaicin.	Capsaicin	187-196	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	129-132
11734659-5	2001	Systems reported to be inhibited by PIP(2) include (i) cyclic nucleotide-gated channels of the rod (CNG), (ii) transient receptor potential-like (TRPL) Drosophila phototransduction channels, (iii) capsaicin-activated transient receptor potential (TRP) channels (VR1), and (iv) IP(3)-gated calcium release channels (IP3R).	Capsaicin	197-206	pipe	Drosophila melanogaster	36-39
11734659-5	2001	Systems reported to be inhibited by PIP(2) include (i) cyclic nucleotide-gated channels of the rod (CNG), (ii) transient receptor potential-like (TRPL) Drosophila phototransduction channels, (iii) capsaicin-activated transient receptor potential (TRP) channels (VR1), and (iv) IP(3)-gated calcium release channels (IP3R).	Capsaicin	197-206	transient receptor potential-like	Drosophila melanogaster	146-150
11744139-8	2001	After pretreatment with capsaicin, which depletes neurotransmitters in sensory nerves, or methylene blue, a selective guanylate cyclase inhibitor, the protection and the elevated release of CGRP induced by nitroglycerin were abolished.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	190-194
11989621-9	2001	CGRP immunoreactivity around cerebral arteries disappeared after capsaicin treatment.	Capsaicin	65-74	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
11989621-10	2001	The rCBF during the occlusion of bilateral common carotid artery decreased more in the capsaicin group than in the control group.	Capsaicin	87-96	CCAAT/enhancer binding protein zeta	Rattus norvegicus	4-8
11731549-6	2001	With three puffs of capsaicin separated by 10 min, we have found that the potentiation established after 10 min exposure to NGF is no longer evident 10 min after removal of NGF.	Capsaicin	20-29	nerve growth factor	Homo sapiens	124-127
11731549-6	2001	With three puffs of capsaicin separated by 10 min, we have found that the potentiation established after 10 min exposure to NGF is no longer evident 10 min after removal of NGF.	Capsaicin	20-29	nerve growth factor	Homo sapiens	173-176
11731549-0	2001	Acute sensitization by NGF of the response of small-diameter sensory neurons to capsaicin.	Capsaicin	80-89	nerve growth factor	Homo sapiens	23-26
11731549-10	2001	Surprisingly, PD98059, which previously has been shown to diminish the enhancement of capsaicin responses of dissociated neurons when exposed to NGF for several days, had no effect on the acute response to NGF; nor did the PKC inhibitor.	Capsaicin	86-95	nerve growth factor	Homo sapiens	145-148
11731549-1	2001	We investigated acute sensitization by nerve growth factor (NGF) of the response of small-diameter (<30 microm) dissociated dorsal root ganglion (DRG) cells to brief repeated puffs of capsaicin as a model for thermal hyperalgesia induced by NGF.	Capsaicin	187-196	nerve growth factor	Homo sapiens	60-63
11731549-2	2001	We have previously shown that placing NGF in the bath after an initial puff of capsaicin can completely overcome the tachyphylaxis normally observed in response to a second puff 10 min later, and this response is often substantially larger than the first.	Capsaicin	79-88	nerve growth factor	Homo sapiens	38-41
11731549-11	2001	However, PKA inhibitors reduced the capsaicin response of the cells to NGF (as determined from the NGF effect on tachyphylaxis).	Capsaicin	36-45	nerve growth factor	Homo sapiens	71-74
11731549-11	2001	However, PKA inhibitors reduced the capsaicin response of the cells to NGF (as determined from the NGF effect on tachyphylaxis).	Capsaicin	36-45	nerve growth factor	Homo sapiens	99-102
11731549-12	2001	Consistent with these findings we confirmed that forskolin, a PKA activator, enhances the effect of NGF on the capsaicin response.	Capsaicin	111-120	nerve growth factor	Homo sapiens	100-103
11787758-3	2001	Capsaicin-evoked protection is abolished by blockade of calcitonin gene-related peptide (CGRP) receptors and inhibition of nitric oxide (NO) synthase.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	56-87
11714880-0	2001	alpha2A-adrenoceptor stimulation reduces capsaicin-induced glutamate release from spinal cord synaptosomes.	Capsaicin	41-50	adrenoceptor alpha 2A	Rattus norvegicus	0-20
11787760-18	2001	The pretreatment with L-NNA to inhibit NO-synthase activity attenuated significantly the protective and hyperemic effects of CCK but not those of leptin while capsaicin denervation counteracted leptin-induced protection and rise in the GBF but attenuated significantly those of CCK.	Capsaicin	159-168	leptin	Rattus norvegicus	194-200
11787758-3	2001	Capsaicin-evoked protection is abolished by blockade of calcitonin gene-related peptide (CGRP) receptors and inhibition of nitric oxide (NO) synthase.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
11710915-7	2001	Additional studies also demonstrated a significant in vivo upregulation of keratinocyte nerve growth factor expression in murine epidermis after the topical application of the neuropeptide releasing agent capsaicin.	Capsaicin	205-214	nerve growth factor	Mus musculus	88-107
11765591-1	2001	Topically applied capsaicin (CAS 404-86-4) induces the release of substance P, a neurotransmitter, from sensory C-fibres.	Capsaicin	18-27	tachykinin precursor 1	Homo sapiens	66-77
11604990-2	2001	Gavage with capsaicin and rotenone significantly elevated phase II enzymes, glutathione S-transferase (GST) and quinone reductase (QR), in the liver and colon.	Capsaicin	12-21	hematopoietic prostaglandin D synthase	Rattus norvegicus	76-101
11604990-2	2001	Gavage with capsaicin and rotenone significantly elevated phase II enzymes, glutathione S-transferase (GST) and quinone reductase (QR), in the liver and colon.	Capsaicin	12-21	hematopoietic prostaglandin D synthase	Rattus norvegicus	103-106
11701132-5	2001	Although perivagal capsaicin treatment attenuated MP-induced Fos expression, capsaicin treatment did not affect brain Fos expression produced by 2,5-AM.	Capsaicin	19-28	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	61-64
11701132-6	2001	It is concluded that (1) brain Fos expression is not always related to the effects of 2,5-AM on feeding, (2) capsaicin-sensitive hepatic vagal afferent fibers carry the signal that stimulates feeding following 2,5-AM treatment, and (3) MP-induced feeding and brain Fos expression is mediated in part by capsaicin-sensitive fibers.	Capsaicin	109-118	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	265-268
11717450-9	2001	Protection exerted by PAR-2 in TNBS-treated mice was reverted by injecting mice with a truncated form of calcitonin gene-related peptide and by sensory neurons ablation with the neurotoxin capsaicin.	Capsaicin	189-198	coagulation factor II (thrombin) receptor-like 1	Mus musculus	22-27
11698614-3	2001	Using a specific proteinase-activated receptor 2 activating peptide, we found evidence of such sensitization in vitro in the form of enhanced capsaicin- and KCl-evoked release of calcitonin gene-related peptide, a marker for nociceptive signaling.	Capsaicin	142-151	F2R like trypsin receptor 1	Homo sapiens	17-48
11683903-0	2001	Capsaicin-evoked CGRP release from rat buccal mucosa: development of a model system for studying trigeminal mechanisms of neurogenic inflammation.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
11685701-0	2001	Novel capsaicin (VR1) and purinergic (P2X3) receptors in Hirschsprung"s intestine.	Capsaicin	6-15	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-20
11691869-4	2001	Acute capsaicin application (10 microM) to the serosal site of the Ussing chamber evoked a secretory response which was blocked by tetrodotoxin (1 microM), the combined application of the NK1 and NK3 receptor antagonists CP-99,994-1 and SR 142801 (1 microM), and by combined application of atropine (10 microM) and the VIP receptor antagonist VIP(6-28) (10 microM).	Capsaicin	6-15	neuromedin-K receptor	Cavia porcellus	196-208
11698030-5	2001	In agreement with these findings, neonatal capsaicin treatment that induces degeneration of capsaicin-sensitive, vanilloid VR1 receptor-expressing, thin, unmyelinated, nociceptive primary afferent fibres significantly reduced the cannabinoid CB(1) receptor immunostaining in the superficial spinal dorsal horn.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	123-126
11698030-5	2001	In agreement with these findings, neonatal capsaicin treatment that induces degeneration of capsaicin-sensitive, vanilloid VR1 receptor-expressing, thin, unmyelinated, nociceptive primary afferent fibres significantly reduced the cannabinoid CB(1) receptor immunostaining in the superficial spinal dorsal horn.	Capsaicin	92-101	transient receptor potential cation channel subfamily V member 1	Homo sapiens	123-126
11588121-13	2001	Capsazepine, ruthenium red, or acute VR1 desensitization by capsaicin-pretreatment, markedly attenuated the reflex CVR responses evoked by anandamide and capsaicin (P< 0.05; paired Student"s t-test).	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-40
11588121-13	2001	Capsazepine, ruthenium red, or acute VR1 desensitization by capsaicin-pretreatment, markedly attenuated the reflex CVR responses evoked by anandamide and capsaicin (P< 0.05; paired Student"s t-test).	Capsaicin	154-163	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-40
11606325-9	2001	CBD (10 microM) desensitized VR1 to the action of capsaicin.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-32
11703449-2	2001	We have previously reported that capsaicin induces receptor-mediated and Ca++-dependent calcitonin gene-related peptide (CGRP) release from axons of the isolated rat sciatic nerve.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	88-119
11703449-2	2001	We have previously reported that capsaicin induces receptor-mediated and Ca++-dependent calcitonin gene-related peptide (CGRP) release from axons of the isolated rat sciatic nerve.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	121-125
11703449-7	2001	The sciatic nerve axons responded to heat, potassium and capsaicin stimulation with a Ca++-dependent CGRP release.	Capsaicin	57-66	calcitonin-related polypeptide alpha	Rattus norvegicus	101-105
11703449-9	2001	We conclude therefore that other heat-activated ion channels than VR1 and VRL1 in capsaicin-sensitive and -insensitive nerve fibres may cause excitation, axonal Ca++ influx and subsequent CGRP release.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-69
11703449-9	2001	We conclude therefore that other heat-activated ion channels than VR1 and VRL1 in capsaicin-sensitive and -insensitive nerve fibres may cause excitation, axonal Ca++ influx and subsequent CGRP release.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	74-78
11703449-9	2001	We conclude therefore that other heat-activated ion channels than VR1 and VRL1 in capsaicin-sensitive and -insensitive nerve fibres may cause excitation, axonal Ca++ influx and subsequent CGRP release.	Capsaicin	82-91	calcitonin-related polypeptide alpha	Rattus norvegicus	188-192
11593105-7	2001	RESULTS: CGRP contents in DRG were decreased by capsaicin (P < 0.05).	Capsaicin	48-57	calcitonin-related polypeptide alpha	Rattus norvegicus	9-13
11593105-12	2001	Furthermore, PD 123319 attenuates the development of hypertension in salt-loaded rats neonatally treated with capsaicin, indicating that the AT2 receptor contributes to the increase in blood pressure.	Capsaicin	110-119	angiotensin II receptor, type 2	Rattus norvegicus	141-144
11749870-7	2001	Pretreatment with L-NAME, an inhibitor of NOS, or capsaicin, which selectively depleted sensory neurotransmitter content, abolished the protective effects and the increased level of CGRP elicited by hyperthermia.	Capsaicin	50-59	calcitonin-related polypeptide alpha	Rattus norvegicus	182-186
11561085-7	2001	The major voltage-gated K+ channel in Jurkat cells, Kv1.3, is also blocked by capsaicin.	Capsaicin	78-87	potassium voltage-gated channel subfamily D member 3	Homo sapiens	10-34
11561085-7	2001	The major voltage-gated K+ channel in Jurkat cells, Kv1.3, is also blocked by capsaicin.	Capsaicin	78-87	potassium voltage-gated channel subfamily A member 3	Homo sapiens	52-57
11561085-10	2001	Upon application of capsaicin to Jurkat cells in culture we observed an inhibition of interleukin-2 (IL-2) production in response to TCR stimulation.	Capsaicin	20-29	interleukin 2	Homo sapiens	86-99
11561085-10	2001	Upon application of capsaicin to Jurkat cells in culture we observed an inhibition of interleukin-2 (IL-2) production in response to TCR stimulation.	Capsaicin	20-29	interleukin 2	Homo sapiens	101-105
11561085-11	2001	The dose dependence of capsaicin"s reduction of IL-2 was comparable with its block of I(CRAC), thereby illustrating the functional relevance of capsaicin"s block of lymphocyte CCE.	Capsaicin	23-32	interleukin 2	Homo sapiens	48-52
11495685-7	2001	CGRP 27-37 analogues reduced the duration of CGRP-, capsaicin- and BK-induced vasodilatation by more than 50%.	Capsaicin	52-61	Calcitonin gene-related peptide	Sus scrofa	0-4
11495685-10	2001	It is concluded that CGRP 27-37 analogues antagonise the action of exogenous CGRP, capsaicin, BK and histamine by attenuating their vasodilatation effect, both in intensity and duration.	Capsaicin	83-92	Calcitonin gene-related peptide	Sus scrofa	21-25
11495686-4	2001	In isolated perfused antrum, vagus nerve stimulation (8 Hz) and capsaicin (10(-5) M) increased PACAP 1-38 release.	Capsaicin	64-73	adenylate cyclase activating polypeptide 1	Homo sapiens	95-100
11567657-9	2001	Gastroprotective and hyperemic actions of standard ischemic preconditioning were abolished by pretreatment with capsaicin-inactivating sensory nerves, but restored by the administration of exogenous CGRP to capsaicin-treated animals.	Capsaicin	207-216	calcitonin related polypeptide alpha	Homo sapiens	199-203
11557265-7	2001	Intestinal preconditioning caused a significant increase in plasma concentrations of CGRP, and the effect was also abolished by L-NAME or capsaicin.	Capsaicin	138-147	calcitonin-related polypeptide alpha	Rattus norvegicus	85-89
11524156-1	2001	The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-24
11524156-1	2001	The vanilloid receptor-1 (VR1) is activated by capsaicin, heat and protons and is localized on primary sensory neurons.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-29
11535926-1	2001	BACKGROUND: We previously reported that lafutidine ((I)-2-(furfurylsulfinyl)-N-[4-[4-(piperidinomethyl)-2-pyridyl]oxy-(Z)-2-butenyl] acetamide), a novel histamine H(2)-receptor antagonist, protects the small intestine against indomethacin-induced damage, mediated by capsaicin-sensitive afferent neurons (CSN).	Capsaicin	267-276	histamine receptor H 2	Rattus norvegicus	153-176
11685550-1	2001	Vanilloid receptor subtype 1 (VR1) is a non-selective cation channel detected on sensory neurons that is sensitive to capsaicin, the main pungent ingredient of hot chili pepper.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-28
11685550-1	2001	Vanilloid receptor subtype 1 (VR1) is a non-selective cation channel detected on sensory neurons that is sensitive to capsaicin, the main pungent ingredient of hot chili pepper.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	30-33
11716363-5	2001	Treatment of neonatal rat pups (1-2 days old) with capsaicin (50 mg/kg), resulted in the permanent de-afferentation of small-diameter unmyelinated CGRP-containing sensory C-fibres.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	147-151
11478769-9	2001	However, capsaicin-induced [Ca(2+)](i) transient was not affected by 2-APB, a membrane-permeable IP(3) receptor antagonist.	Capsaicin	9-18	inositol 1,4,5-trisphosphate receptor, type 3	Rattus norvegicus	97-111
11521167-10	2001	Capsaicin (10 microM) increased both CGRP-LI and NKA-LI release from superfused slices of hamster urinary bladder by about sixfold and by about 70%, over baseline, respectively.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	37-41
11521167-12	2001	In the hamster urinary bladder the sensory neuropeptides NKA and CGRP are co-released by sensory fibers after stimulation either by EFS or capsaicin.	Capsaicin	139-148	calcitonin related polypeptide alpha	Homo sapiens	65-69
11514026-3	2001	Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-38
11514026-3	2001	Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation.	Capsaicin	160-169	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-38
11514026-3	2001	Intraluminal administration of the VR1 agonist capsaicin caused intestinal inflammation similar to the effects of toxin A. Pretreatment with capsazepine before capsaicin administration also significantly inhibited capsaicin-induced intestinal inflammation.	Capsaicin	160-169	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-38
11489540-8	2001	Both the VR1 immunoreactivity and the receptor density of [3H]-RTX binding sites significantly reduced by the application of capsaicin for prolonged periods of time in the mucosa of rats.	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-12
11514080-5	2001	Capsaicin, heat and pH 5.2 were able to induce significant increases in calcitonin gene related peptide (CGRP) release (14.6-, 5.1-, and 2.3-fold over baseline), however, only capsaicin induced a significant increase in substance P (SP) levels (1.8-fold over baseline).	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	72-103
11514080-5	2001	Capsaicin, heat and pH 5.2 were able to induce significant increases in calcitonin gene related peptide (CGRP) release (14.6-, 5.1-, and 2.3-fold over baseline), however, only capsaicin induced a significant increase in substance P (SP) levels (1.8-fold over baseline).	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	105-109
11514080-5	2001	Capsaicin, heat and pH 5.2 were able to induce significant increases in calcitonin gene related peptide (CGRP) release (14.6-, 5.1-, and 2.3-fold over baseline), however, only capsaicin induced a significant increase in substance P (SP) levels (1.8-fold over baseline).	Capsaicin	0-9	tachykinin 1	Mus musculus	233-235
11333266-2	2001	VR1, which binds and is activated by capsaicin and other vanilloid compounds, was noted to interact with the endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic acid in a pH-dependent manner.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-3
11333266-2	2001	VR1, which binds and is activated by capsaicin and other vanilloid compounds, was noted to interact with the endocannabinoid anandamide (ANA) and certain inflammatory metabolites of arachidonic acid in a pH-dependent manner.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-3
11466438-8	2001	By contrast, P2X antagonists [2",3"-O-(2,4,6-trinitrophenyl)-ATP and pyridoxal 5-phosphate 6-azophenyl-2",4"-disulfonic acid] and capsaicin attenuated distension-induced discharges in bladder afferents.	Capsaicin	130-139	purinergic receptor P2X, ligand-gated ion channel, 1	Mus musculus	13-16
11556883-8	2001	The cNOS enzymatic activity in thoracic spinal tissue was gradually decreased to a minimum at 72 h. Down-regulation of NOS by SP(1-7) in the thoracic area appears to be highly associated with capsaicin-sensitive primary afferent neurons.	Capsaicin	192-201	nitric oxide synthase 1	Rattus norvegicus	4-8
11483711-0	2001	Protein kinase C activation potentiates gating of the vanilloid receptor VR1 by capsaicin, protons, heat and anandamide.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-76
11483711-5	2001	Bradykinin, which activates PKC, also enhanced the response to capsaicin in DRG neurones.	Capsaicin	63-72	kininogen 1	Homo sapiens	0-10
11507729-5	2001	Plasma insulin levels measured at the 2.5 h time interval showed that there was an increase in plasma insulin levels of 5.78 +/- 0.76 microIU/mL (n = 6) for the capsaicin treated dogs versus 3.70 +/- 0.43 microIU/mL (n = 10) for the control (p < 0.05).	Capsaicin	161-170	insulin	Canis lupus familiaris	7-14
11507729-10	2001	In conclusion it can be stated that capsaicin is responsible for the hypoglycaemic episodes seen in the dogs and that it also causes an increase in insulin secretion which leads to a reduction of insulin binding on the insulin receptors.	Capsaicin	36-45	insulin	Canis lupus familiaris	148-155
11507729-5	2001	Plasma insulin levels measured at the 2.5 h time interval showed that there was an increase in plasma insulin levels of 5.78 +/- 0.76 microIU/mL (n = 6) for the capsaicin treated dogs versus 3.70 +/- 0.43 microIU/mL (n = 10) for the control (p < 0.05).	Capsaicin	161-170	insulin	Canis lupus familiaris	102-109
11507729-10	2001	In conclusion it can be stated that capsaicin is responsible for the hypoglycaemic episodes seen in the dogs and that it also causes an increase in insulin secretion which leads to a reduction of insulin binding on the insulin receptors.	Capsaicin	36-45	insulin	Canis lupus familiaris	196-203
11507729-8	2001	Insulin affinity results showed that there was a decrease of 2.4 x 10(-4) in monocytes for the capsaicin treated dogs versus 8.77 x 10(-4) for the control (p < 0.05).	Capsaicin	95-104	insulin	Canis lupus familiaris	0-7
11358970-1	2001	Vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that can be activated by capsaicin and other vanilloids as well as by protons and heat.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-28
11358970-1	2001	Vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that can be activated by capsaicin and other vanilloids as well as by protons and heat.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-33
11543953-7	2001	Summated EPSCs were attenuated or abolished by capsaicin pretreatment, which depletes SP and NKA from presynaptic terminals; SP and NKA pretreatment; NK(1) or NK(2) receptor antagonists; and inhibition of postsynaptic G proteins.	Capsaicin	47-56	tachykinin receptor 2	Rattus norvegicus	159-173
11448475-0	2001	Temperature-dependent activation of recombinant rat vanilloid VR1 receptors expressed in HEK293 cells by capsaicin and anandamide.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-65
11448475-1	2001	Capsaicin activates vanilloid (VR1) receptors found on sensory neurons.	Capsaicin	0-9	vault RNA 1-1	Homo sapiens	31-34
11448475-3	2001	In this study, we have measured capsaicin- and anandamide-induced elevations in intracellular calcium concentrations ([Ca(2+)](i)) in fura-2 loaded HEK293 cells stably expressing the rat VR1 receptor at 22, 37 and 50 degrees C. Both capsaicin and anandamide produced a concentration-dependent elevation in [Ca(2+)](i) at all temperatures.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	187-190
11448475-3	2001	In this study, we have measured capsaicin- and anandamide-induced elevations in intracellular calcium concentrations ([Ca(2+)](i)) in fura-2 loaded HEK293 cells stably expressing the rat VR1 receptor at 22, 37 and 50 degrees C. Both capsaicin and anandamide produced a concentration-dependent elevation in [Ca(2+)](i) at all temperatures.	Capsaicin	233-242	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	187-190
11534859-11	2001	Moreover, after 24-h incubation, RA (0.1 mM) significantly decreased the capsaicin (1 microM)-induced calcitonin gene-related peptide (CGRP) release from rat DRG neurons, whereas acute drug superfusion did not evoke CGRP release by itself.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	102-133
11534859-11	2001	Moreover, after 24-h incubation, RA (0.1 mM) significantly decreased the capsaicin (1 microM)-induced calcitonin gene-related peptide (CGRP) release from rat DRG neurons, whereas acute drug superfusion did not evoke CGRP release by itself.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	135-139
11534859-11	2001	Moreover, after 24-h incubation, RA (0.1 mM) significantly decreased the capsaicin (1 microM)-induced calcitonin gene-related peptide (CGRP) release from rat DRG neurons, whereas acute drug superfusion did not evoke CGRP release by itself.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	216-220
11553280-1	2001	The cloned vanilloid receptor VR1 can be activated by capsaicin and by thermal stimuli.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	30-33
19003326-2	2001	There was an increase in permeability at high concentration (200 to 500 muM) of capsaicin, and the effect was inhibited by pretreatment of capsazepine, which is a competitive antagonist of the vanilloid receptor 1 (VR1).	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	193-213
19003326-2	2001	There was an increase in permeability at high concentration (200 to 500 muM) of capsaicin, and the effect was inhibited by pretreatment of capsazepine, which is a competitive antagonist of the vanilloid receptor 1 (VR1).	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	215-218
19003326-5	2001	Our results showed that the permeability increase by capsaicin was through binding to VR1-like protein of Caco-2 cells.	Capsaicin	53-62	transient receptor potential cation channel subfamily V member 1	Homo sapiens	86-89
11531896-4	2001	Intradermal injection of capsaicin in the periorbital area increased c-fos expression in nucleus trigeminalis caudalis; this was significantly potentiated by glyceryl trinitrate.	Capsaicin	25-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-74
11461957-7	2001	Conversely capsaicin-induced release of SOM (EC(50) 50 nM) was not modified by GDNF treatment.	Capsaicin	11-20	somatostatin	Rattus norvegicus	40-43
11488950-2	2001	Recent studies have shown a synergistic interaction between leptin and cholecystokinin (CCK) leading to suppression of food intake, which involves CCK-1 receptors and capsaicin-sensitive vagal fibres.	Capsaicin	167-176	cholecystokinin	Rattus norvegicus	71-86
11488950-2	2001	Recent studies have shown a synergistic interaction between leptin and cholecystokinin (CCK) leading to suppression of food intake, which involves CCK-1 receptors and capsaicin-sensitive vagal fibres.	Capsaicin	167-176	cholecystokinin	Rattus norvegicus	88-91
11488950-2	2001	Recent studies have shown a synergistic interaction between leptin and cholecystokinin (CCK) leading to suppression of food intake, which involves CCK-1 receptors and capsaicin-sensitive vagal fibres.	Capsaicin	167-176	leptin	Rattus norvegicus	60-66
11488437-0	2001	Transient prevention of ethanol-induced gastric lesion by capsaicin due to release of endogenous calcitonin gene-related peptide in rats.	Capsaicin	58-67	calcitonin-related polypeptide alpha	Rattus norvegicus	97-128
11488437-2	2001	Treatment with an antagonist of calcitonin gene-related peptide (CGRP), CGRP (8-37), nullified the effect of capsaicin.	Capsaicin	109-118	calcitonin-related polypeptide alpha	Rattus norvegicus	32-63
11488437-2	2001	Treatment with an antagonist of calcitonin gene-related peptide (CGRP), CGRP (8-37), nullified the effect of capsaicin.	Capsaicin	109-118	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
11488437-2	2001	Treatment with an antagonist of calcitonin gene-related peptide (CGRP), CGRP (8-37), nullified the effect of capsaicin.	Capsaicin	109-118	calcitonin-related polypeptide alpha	Rattus norvegicus	72-76
11488437-3	2001	During constant perfusion of the gastric lumen with physiological saline + pepstatin, the CGRP level was not increased by 50% ethanol, but it showed a peak (802.5 +/- 145.7 pg/2 min) after 1.6 mM capsaicin.	Capsaicin	196-205	calcitonin-related polypeptide alpha	Rattus norvegicus	90-94
11488437-4	2001	Four minutes after capsaicin, the CGRP level was kept at a high level and the gastric lesion was markedly reduced by re-exposure of the mucosa to 50% ethanol.	Capsaicin	19-28	calcitonin-related polypeptide alpha	Rattus norvegicus	34-38
11488437-5	2001	At 20-30 min after capsaicin, the CGRP levels returned to the resting level and the reddened area by 50% ethanol was not reduced.	Capsaicin	19-28	calcitonin-related polypeptide alpha	Rattus norvegicus	34-38
11488437-6	2001	It was concluded that capsaicin transiently prevented the mucosal lesion through CGRP release.	Capsaicin	22-31	calcitonin-related polypeptide alpha	Rattus norvegicus	81-85
11404434-11	2001	This upregulated BDNF content in the DRG and increased the capsaicin-evoked release of BDNF.	Capsaicin	59-68	brain-derived neurotrophic factor	Rattus norvegicus	87-91
11275357-9	2001	Prostaglandins also facilitate membrane currents and release of substance P and CGRP induced by low pH, bradykinin and capsaicin.	Capsaicin	119-128	tachykinin precursor 1	Homo sapiens	64-75
11275357-9	2001	Prostaglandins also facilitate membrane currents and release of substance P and CGRP induced by low pH, bradykinin and capsaicin.	Capsaicin	119-128	calcitonin related polypeptide alpha	Homo sapiens	80-84
11404433-1	2001	The recently cloned vanilloid receptor (VR1) is postulated to account for heat and capsaicin sensitivity in unmyelinated afferents.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-43
11404434-2	2001	Here we show that BDNF is released in the rat isolated dorsal horn after chemical stimulation by capsaicin or electrical stimulation of dorsal roots.	Capsaicin	97-106	brain-derived neurotrophic factor	Rattus norvegicus	18-22
11431028-2	2001	Yet, this compound also efficiently activates receptors specific for capsaicin, known as vanilloid type 1 receptors (VR1).	Capsaicin	69-78	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-120
11371611-4	2001	In cells expressing VR1, ATP increased the currents evoked by capsaicin or protons through activation of metabotropic P2Y(1) receptors in a protein kinase C-dependent pathway.	Capsaicin	62-71	vault RNA 1-1	Homo sapiens	20-23
11404434-3	2001	Capsaicin superfusion (1-100 microm) induced a dose-dependent release of BDNF, measured using ELISA.	Capsaicin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	73-77
11404434-4	2001	The highest dose of capsaicin also induced a depletion of BDNF protein in the dorsal horn.	Capsaicin	20-29	brain-derived neurotrophic factor	Rattus norvegicus	58-62
11356797-2	2001	Perineural capsaicin and indomethacin were used to block conduction of vagal C fibers and production of cyclooxygenase products, respectively.	Capsaicin	11-20	prostaglandin-endoperoxide synthase 1	Canis lupus familiaris	104-118
11418494-3	2001	This method was used to test the hypothesis that the neuromodulator substance P (SP) plays a role in the detection of intra-oral capsaicin.	Capsaicin	129-138	tachykinin 1	Mus musculus	68-79
11418494-3	2001	This method was used to test the hypothesis that the neuromodulator substance P (SP) plays a role in the detection of intra-oral capsaicin.	Capsaicin	129-138	tachykinin 1	Mus musculus	81-83
11772240-6	2001	CGRP-mimetics include capsaicin/vanilloid receptor agonists and gene transfer of an adenoviral vector that encodes prepro-CGRP.	Capsaicin	22-31	calcitonin related polypeptide alpha	Homo sapiens	0-4
11772240-8	2001	CGRP inhibitors include capsaicin, antagonists at capsaicin/vanilloid receptors, civamide, CGRP receptor antagonists and 5-HT1D-receptor agonists.	Capsaicin	24-33	calcitonin related polypeptide alpha	Homo sapiens	0-4
11350816-5	2001	A specific NK(2) receptor antagonist inhibited constriction caused by endogenous tachykinins released by capsaicin.	Capsaicin	105-114	tachykinin receptor 2	Homo sapiens	11-25
11413249-1	2001	The endogenous cannabinoid receptor ligand, anandamide (AEA), is a full agonist of the vanilloid receptor type 1 (VR1) for capsaicin.	Capsaicin	123-132	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-117
11408034-1	2001	Capsaicin and its analogue N-arachidonoyl-vanillyl-amine (arvanil) are agonists of vanilloid VR1 receptors, and suppress spontaneous activity in mice through an unknown mechanism.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	93-96
11368954-0	2001	Histamine H1 receptor mRNA is expressed in capsaicin-insensitive sensory neurons with neuropeptide Y-immunoreactivity in guinea pigs.	Capsaicin	43-52	histamine H1 receptor	Cavia porcellus	0-21
11408034-9	2001	Finally, stimulation with capsaicin of cells expressing rat vanilloid VR1 receptors led to anandamide formation.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	70-73
11408036-11	2001	Capsaicin also abolished the cardioprotection and the increased release of CGRP induced by monophosphoryl lipid A, but did not affect the content of NO.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	75-79
11231043-12	2001	Infusion of capsaicin (10(-5) M) caused a significant increase in the release of CGRP-LI to 485+/-82% of basal output (n=5).	Capsaicin	12-21	calcitonin related polypeptide alpha	Homo sapiens	81-85
11275362-0	2001	Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation.	Capsaicin	0-9	DNL-type zinc finger	Homo sapiens	34-39
11275362-0	2001	Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation.	Capsaicin	0-9	BCL2 apoptosis regulator	Homo sapiens	71-76
11275362-0	2001	Capsaicin-induced apoptosis in SK-Hep-1 hepatocarcinoma cells involves Bcl-2 downregulation and caspase-3 activation.	Capsaicin	0-9	caspase 3	Homo sapiens	96-105
11275362-2	2001	In the present study, we investigated the chemopreventive potential of capsaicin (8-methyl-N- vanillyl-6-nonenamide), the principal pungent ingredient found in hot red pepper, in SK-Hep-1 hepatocellular carcinoma cells.	Capsaicin	71-80	DNL-type zinc finger	Homo sapiens	182-187
11275362-2	2001	In the present study, we investigated the chemopreventive potential of capsaicin (8-methyl-N- vanillyl-6-nonenamide), the principal pungent ingredient found in hot red pepper, in SK-Hep-1 hepatocellular carcinoma cells.	Capsaicin	82-115	DNL-type zinc finger	Homo sapiens	182-187
11275362-3	2001	Treatment of capsaicin inhibited growth of SK-Hep-1 cells in a concentration-dependent manner while 4-methoxy capsaicin (Met-capsaicin) was less potent.	Capsaicin	13-22	DNL-type zinc finger	Homo sapiens	46-51
11275362-4	2001	This inhibitory effect of capsaicin on SK-Hep-1 cell growth was mainly due to the induction of apoptosis as evidenced by DNA fragmentation and nuclear condensation.	Capsaicin	26-35	DNL-type zinc finger	Homo sapiens	42-47
11275362-5	2001	Furthermore, capsaicin prominently reduced the ratio of anti-apoptotic Bcl-2 to pro-apoptotic Bax and consequently increased caspase-3 activity.	Capsaicin	13-22	BCL2 apoptosis regulator	Homo sapiens	71-76
11275362-5	2001	Furthermore, capsaicin prominently reduced the ratio of anti-apoptotic Bcl-2 to pro-apoptotic Bax and consequently increased caspase-3 activity.	Capsaicin	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	94-97
11275362-5	2001	Furthermore, capsaicin prominently reduced the ratio of anti-apoptotic Bcl-2 to pro-apoptotic Bax and consequently increased caspase-3 activity.	Capsaicin	13-22	caspase 3	Homo sapiens	125-134
11275362-6	2001	These results demonstrate that capsaicin efficiently induced apoptosis in SK-Hep-1 cells through a caspase-3-dependent mechanism, which may contribute to its chemopreventive function.	Capsaicin	31-40	DNL-type zinc finger	Homo sapiens	77-82
11275362-6	2001	These results demonstrate that capsaicin efficiently induced apoptosis in SK-Hep-1 cells through a caspase-3-dependent mechanism, which may contribute to its chemopreventive function.	Capsaicin	31-40	caspase 3	Homo sapiens	99-108
11426844-3	2001	It is concluded that, in the rat heart, capsaicin acting on VR1 capsaicin receptors elicits a release of endothelin from the sensory nerve terminals.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	60-63
11292598-1	2001	Epidermal growth factor (EGF) has been shown to exert gastric hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the release of calcitonin gene-related peptide (CGRP).	Capsaicin	105-114	epidermal growth factor	Homo sapiens	0-23
11292598-1	2001	Epidermal growth factor (EGF) has been shown to exert gastric hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the release of calcitonin gene-related peptide (CGRP).	Capsaicin	105-114	epidermal growth factor	Homo sapiens	25-28
11292598-1	2001	Epidermal growth factor (EGF) has been shown to exert gastric hyperemic and gastroprotective effects via capsaicin-sensitive afferent neurons, including the release of calcitonin gene-related peptide (CGRP).	Capsaicin	105-114	calcitonin related polypeptide alpha	Homo sapiens	168-199
11292598-4	2001	The protective effect of EGF was significantly inhibited by pretreatment with capsaicin desensitization, human CGRP1 antagonist hCGRP-(8-37), or N(omega)-nitro-L-arginine methyl ester (L-NAME).	Capsaicin	78-87	epidermal growth factor	Homo sapiens	25-28
11292598-6	2001	These findings suggest that EGF plays a protective role against ethanol-induced gastric mucosal injury, possibly by dilating the gastric mucosal arterioles via capsaicin-sensitive afferent neurons involving CGRP and NO mechanisms.	Capsaicin	160-169	epidermal growth factor	Homo sapiens	28-31
11482756-1	2001	A number of studies have demonstrated that capsaicin, a capsicum alkaloid, can affect isolated bladder tissue with either a relaxation or a contraction, depending on the species, by acting on VR1 receptors.	Capsaicin	43-52	vault RNA 1-1	Homo sapiens	192-195
11482756-2	2001	In a previous work on isolated lamb detrusor, we demonstrated that capsaicin generally produces a relaxation of the tissue; this relaxation seems to be mediated by CGRP.	Capsaicin	67-76	calcitonin related polypeptide alpha	Homo sapiens	164-168
11475796-5	2001	Capsaicin, which induces the release of neurokinins, and neurokinin A can cause contractions of some vascular preparations, suggesting the existence of smooth muscle NK2 receptor associated with contraction.	Capsaicin	0-9	tachykinin receptor 2	Homo sapiens	166-178
11231043-15	2001	The stimulatory effect of capsaicin suggests that CGRP is also released from extrinsic sensory neurons.	Capsaicin	26-35	calcitonin related polypeptide alpha	Homo sapiens	50-54
11124944-4	2001	Within seconds of vanilloid exposure, the intracellular free calcium ([Ca(2+)](i)) was elevated in cells expressing VR1.	Capsaicin	18-27	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-119
11474544-5	2001	In rVR1-transfected HEK293 cells, acidic conditions enhanced the affinities of capsaicin and capsazepine at rVR1, but did not affect the potency of carbachol at endogenous muscarinic receptors.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	3-7
11474544-5	2001	In rVR1-transfected HEK293 cells, acidic conditions enhanced the affinities of capsaicin and capsazepine at rVR1, but did not affect the potency of carbachol at endogenous muscarinic receptors.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	108-112
11474544-8	2001	In conclusion, a decrease in pH (to 6.9 and 6.3) enhances the affinity of capsaicin at rVR1, but inhibits sensory neurotransmission in the rat mesenteric arterial bed.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-91
11301059-2	2001	In whole-cell patch clamp studies, capsaicin (10 microM) elicited a slowly activating/deactivating inward current in human embryonic kidney (HEK293) cells stably expressing human vanilloid VR1 receptor, which exhibited pronounced outward rectification (reversal potential -2.1+/-0.2 mV) and was abolished by capsazepine (10 microM).	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	189-192
11171624-11	2001	Capsaicin treatment not only significantly reduced the Fos-positive neuron numbers in portal hypertensive and cirrhotic rats but also attenuated hemorrhage-induced Fos and double-positive cells in both NTS and VLM.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-58
11179825-0	2001	Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis.	Capsaicin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	57-66
11179825-0	2001	Capsaicin suppresses phorbol ester-induced activation of NF-kappaB/Rel and AP-1 transcription factors in mouse epidermis.	Capsaicin	0-9	jun proto-oncogene	Mus musculus	75-79
11179825-2	2001	In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.	Capsaicin	45-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	150-159
11179825-2	2001	In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.	Capsaicin	45-54	nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha	Mus musculus	176-189
11179825-2	2001	In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.	Capsaicin	45-54	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	281-290
11179825-2	2001	In the present study, topical application of capsaicin onto dorsal skin of female ICR mice strongly suppressed phorbol ester-stimulated activation of NF-kappaB via blockade of IkappaB-alpha degradation with subsequent inhibition of nuclear translocation of the functionally active NF-kappaB subunit, p65.	Capsaicin	45-54	v-rel reticuloendotheliosis viral oncogene homolog A (avian)	Mus musculus	300-303
11179825-3	2001	Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment.	Capsaicin	90-99	jun proto-oncogene	Mus musculus	46-65
11179825-3	2001	Likewise, phorbol ester-induced activation of activator protein-1 (AP-1) was abolished by capsaicin pretreatment.	Capsaicin	90-99	jun proto-oncogene	Mus musculus	67-71
11179825-4	2001	Since altered transactivation of NF-kappaB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation.	Capsaicin	169-178	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	33-42
11179825-4	2001	Since altered transactivation of NF-kappaB and AP-1 has been implicated for neoplastic transformation and progression, the suppression of these transcription factors by capsaicin may account for its previously reported chemopreventive effects on mouse skin tumorigenesis as well as inflammation.	Capsaicin	169-178	jun proto-oncogene	Mus musculus	47-51
11278420-1	2001	The endogenous ligand of CB(1) cannabinoid receptors, anandamide, is also a full agonist at vanilloid VR1 receptors for capsaicin and resiniferatoxin, thereby causing an increase in cytosolic Ca(2+) concentration in human VR1-overexpressing (hVR1-HEK) cells.	Capsaicin	120-129	vault RNA 1-1	Homo sapiens	102-105
11278420-8	2001	By contrast, the CB(1) receptor antagonist SR141716A inhibited also the VR1-mediated effect of anandamide and capsaicin on cytosolic Ca(2+) concentration, although at concentrations higher than those required for CB(1) antagonism.	Capsaicin	110-119	vault RNA 1-1	Homo sapiens	72-75
11171624-11	2001	Capsaicin treatment not only significantly reduced the Fos-positive neuron numbers in portal hypertensive and cirrhotic rats but also attenuated hemorrhage-induced Fos and double-positive cells in both NTS and VLM.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	164-167
11171630-1	2001	We previously showed that the duodenal hyperemic response to acid occurs through activation of capsaicin-sensitive afferent nerves with subsequent release of vasodilatory substances such as calcitonin gene-related peptide (CGRP) and nitric oxide.	Capsaicin	95-104	calcitonin-related polypeptide alpha	Rattus norvegicus	190-221
11171630-1	2001	We previously showed that the duodenal hyperemic response to acid occurs through activation of capsaicin-sensitive afferent nerves with subsequent release of vasodilatory substances such as calcitonin gene-related peptide (CGRP) and nitric oxide.	Capsaicin	95-104	calcitonin-related polypeptide alpha	Rattus norvegicus	223-227
11124144-0	2001	ACTH inhibits the capsaicin-evoked release of CGRP from rat adrenal afferent nerves.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	46-50
11226139-2	2001	Both rat and human VR1 formed ligand gated channels that were activated by capsaicin with similar EC(50) values.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-22
11226139-8	2001	Capsazepine and ruthenium red were both more potent at blocking the capsaicin response of human VR1 than rat VR1.	Capsaicin	68-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-99
11259480-0	2001	Axonal transport of VR1 capsaicin receptor mRNA in primary afferents and its participation in inflammation-induced increase in capsaicin sensitivity.	Capsaicin	24-33	vault RNA 1-1	Homo sapiens	20-23
11259480-2	2001	We examined the inflammation-induced changes of the level of VR1 capsaicin receptor mRNA in sensory neurons and the sensitivity of primary afferents to capsaicin.	Capsaicin	65-74	vault RNA 1-1	Homo sapiens	61-64
11259480-4	2001	The sensitivity of central terminals to capsaicin, which was estimated by measuring the capsaicin-evoked release of glutamate from the dorsal horn, was increased by peripheral inflammation, and such an increase was suppressed by inhibiting the RNA translation in the dorsal horn with cycloheximide and an intrathecal injection of VR1 antisense oligonucleotides.	Capsaicin	40-49	vault RNA 1-1	Homo sapiens	330-333
11259480-5	2001	Thus, peripheral inflammation induces the axonal transport of VR1 mRNA, which may be involved in the hypersensitivity of primary afferents to capsaicin and the production of inflammatory hyperalgesia.	Capsaicin	142-151	vault RNA 1-1	Homo sapiens	62-65
11166956-1	2001	Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-45
11166956-1	2001	Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-50
11166956-1	2001	Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property.	Capsaicin	91-94	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-45
11166956-1	2001	Heterologously expressed vanilloid receptor 1 (VR1), a cloned cDNA encoding for capsaicin (CAP)-sensitive currents, resembles the native CAP channels in cultured sensory neurons in channel property.	Capsaicin	91-94	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-50
11741519-8	2001	However, the elevated level of CGRP-LI by nitroglycerin was abolished by pretreatment with capsaicin.	Capsaicin	91-100	calcitonin-related polypeptide alpha	Rattus norvegicus	31-35
11145711-7	2001	The augmented ACD response in NEP(-/-) animals was abrogated by either administration of a neurokinin receptor 1 antagonist or by repeated pretreatment with topical capsaicin.	Capsaicin	165-174	membrane metallo endopeptidase	Mus musculus	30-33
12162579-7	2001	Endothelin-1 (0.1 nM), the putative mediator of the capsaicin effect, significantly decreased heart rate and coronary flow irrespective of the presence or absence of diabetes.	Capsaicin	52-61	endothelin 1	Rattus norvegicus	0-12
11243859-1	2001	The irritant action of capsaicin is mediated by the vanilloid receptor, VR1, which is expressed in sensory neurons termed nociceptors.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-75
11243859-6	2001	Capsaicin (EC(50) = 853 nM), low pH (<5.5), and noxious heat (44 degrees C) activate hVR1 expressed in Xenopus oocytes.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-92
11243859-7	2001	Subthreshold pH (6.4) sensitizes VR1 to capsaicin (EC(50) = 221 nM).	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-36
11209117-12	2001	Depletion of substance P was demonstrated by confocal laser scanning microscopy thus confirming the specific effect of capsaicin in vivo.	Capsaicin	119-128	tachykinin precursor 1	Homo sapiens	13-24
11160380-8	2001	Results indicate that stimulation of VR-1 with high concentrations of AEA excites central terminals of capsaicin-sensitive DRG neurons, thus causing neuropeptide release in the dorsal spinal cord.	Capsaicin	103-112	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-41
11106844-1	2001	Capsaicinoids have been suggested as an aid in identifying Capsicum species.	Capsaicin	0-13	activation induced cytidine deaminase	Homo sapiens	40-43
11166975-0	2001	Role of central and peripheral tachykinin NK1 receptors in capsaicin-induced pain and hyperalgesia in mice.	Capsaicin	59-68	tachykinin 1	Mus musculus	42-45
11166975-8	2001	Selective blockade of peripheral NK1 receptors in WT mice resulted in a complete inhibition of capsaicin-evoked plasma extravasation, but the mechanical hyperalgesia induced by 30 microg capsaicin intraplantar was still significantly greater than that seen in KO mice.	Capsaicin	95-104	tachykinin 1	Mus musculus	33-36
11166975-8	2001	Selective blockade of peripheral NK1 receptors in WT mice resulted in a complete inhibition of capsaicin-evoked plasma extravasation, but the mechanical hyperalgesia induced by 30 microg capsaicin intraplantar was still significantly greater than that seen in KO mice.	Capsaicin	187-196	tachykinin 1	Mus musculus	33-36
11166975-9	2001	We conclude that the response to intradermal capsaicin is still present but abbreviated in mice lacking NK1 receptors, such that secondary hyperalgesia is not observed even after a high dose.	Capsaicin	45-54	tachykinin 1	Mus musculus	104-107
11217909-0	2001	The ACE gene polymorphism and cough threshold for capsaicin after cilazapril usage.	Capsaicin	50-59	angiotensin I converting enzyme	Homo sapiens	4-7
11354801-0	2001	[NADPH-diaphorase activity and Fos expression in brainstem nuclei involved in cardiovascular regulation following intracarotid injection of capsaicin].	Capsaicin	140-149	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	31-34
11354801-1	2001	The present study was undertaken to define whether intracarotid injection of capsaicin induces Fos expression associated with the activation of NOS-containing neurons in brainstem nuclei by combining the immunocytochemical method for Fos with NADPH-d histochemical technique for NOS.	Capsaicin	77-86	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	95-98
11354801-1	2001	The present study was undertaken to define whether intracarotid injection of capsaicin induces Fos expression associated with the activation of NOS-containing neurons in brainstem nuclei by combining the immunocytochemical method for Fos with NADPH-d histochemical technique for NOS.	Capsaicin	77-86	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	234-237
11354801-2	2001	The results obtained are as follows: (1) Intracarotid injection of capsaicin caused a significant increase of Fos-like immunoreactive neurons in area postrema (AP), nucleus tractus solitarius (NTS), paragigantocellularis lateralis (PGL) and locus coeruleus (LC), without influence upon the neurons of raphe nuclei (RN) and periaqueductal gray (PAG).	Capsaicin	67-76	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	110-113
11124144-4	2001	Capsaicin-evoked CGRP release from adrenal afferents was blocked by capsazepine, a competitive antagonist for the capsaicin receptor, or by removal of extracellular calcium.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	114-132
11124144-5	2001	Exogenous ACTH prevented capsaicin-evoked CGRP release, elevated basal aldosterone release, and prevented capsaicin-induced reduction in aldosterone release.	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
11124144-3	2001	The present studies validate an in vitro superfusion technique for adrenal capsules employing the drug capsaicin, which activates a subset of afferent fibers and induces the release of calcitonin gene-related peptide (CGRP).	Capsaicin	103-112	calcitonin-related polypeptide alpha	Rattus norvegicus	185-216
11124144-3	2001	The present studies validate an in vitro superfusion technique for adrenal capsules employing the drug capsaicin, which activates a subset of afferent fibers and induces the release of calcitonin gene-related peptide (CGRP).	Capsaicin	103-112	calcitonin-related polypeptide alpha	Rattus norvegicus	218-222
11124144-4	2001	Capsaicin-evoked CGRP release from adrenal afferents was blocked by capsazepine, a competitive antagonist for the capsaicin receptor, or by removal of extracellular calcium.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
11435748-8	2001	Capsaicin-induced desensitization also resulted in significantly higher plasma levels of IL-6 and TNF 1 but not 4 h after LPS challenge.	Capsaicin	0-9	interleukin 6	Rattus norvegicus	89-93
11587243-2	2001	These neurons carry receptors that bind capsaicin, recently identified as the vanilloid VR1 receptor.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-91
11587243-12	2001	The discovery of VR1-expressing cells in the brain as well as in non-neural tissues such as the kidney and urothelium places VR1 in a much broader perspective than peripheral pain perception, and is hoped to identify further, yet unsuspected, indications for vanilloid therapy.	Capsaicin	259-268	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-20
11587243-13	2001	The realisation that VR1 and cannabinoid CB1 receptors have overlapping ligand recognition properties may also have far-reaching implications for vanilloid therapy.	Capsaicin	146-155	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-24
11587243-13	2001	The realisation that VR1 and cannabinoid CB1 receptors have overlapping ligand recognition properties may also have far-reaching implications for vanilloid therapy.	Capsaicin	146-155	cannabinoid receptor 1	Homo sapiens	41-44
11595421-12	2001	In addition, PGI(2) and its receptors may play a crucial role in capsaicin-induced gastric protection but not in the adaptive cytoprotection-induced by mild irritants.	Capsaicin	65-74	prostaglandin I receptor (IP)	Mus musculus	13-18
11595435-4	2001	(1) Cloning the capsaicin VR-1 receptor (an ion channel-coupled receptor) and raising the VR-1 knockout mice provided a definite molecular background for the existence of capsaicin-sensitive afferents with both sensory and mediator releasing functions in the stomach.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-30
11595435-6	2001	(2) VR-1 agonists (capsaicin, resiniferatoxin, piperine) protect against gastric ulcer of the rat parallel with their sensory stimulating potencies.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-8
11595435-7	2001	(3) Antidromic stimulation of capsaicin-sensitive vagal and somatic afferents results in the release of CGRP, tachykinins, NO and somatostatin.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	104-108
11595449-3	2001	THE AIM OF OUR STUDY was to evaluate the changes in the tissue level of aquaporins (AQP1 and AQP4) after ethanol and capsaicin treatment in rat stomach.	Capsaicin	117-126	aquaporin 1	Rattus norvegicus	84-88
11595449-3	2001	THE AIM OF OUR STUDY was to evaluate the changes in the tissue level of aquaporins (AQP1 and AQP4) after ethanol and capsaicin treatment in rat stomach.	Capsaicin	117-126	aquaporin 4	Rattus norvegicus	93-97
11125018-4	2001	The pharmacology of recombinant rodent VR1 and the endogenous rat VR1 was indistinguishable when measuring displacement of [125I]RTX binding (i.e., the following rank order of affinity was observed: RTX > I-RTX > olvanil > capsaicin > capsazepine).	Capsaicin	232-241	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	39-42
11125018-4	2001	The pharmacology of recombinant rodent VR1 and the endogenous rat VR1 was indistinguishable when measuring displacement of [125I]RTX binding (i.e., the following rank order of affinity was observed: RTX > I-RTX > olvanil > capsaicin > capsazepine).	Capsaicin	232-241	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-69
11125018-5	2001	Capsaicin and RTX induced large nondesensitizing currents in Xenopus laevis oocytes expressing VR1 (EC50 values were 1300 nM and 0.2 nM, respectively), whereas I-RTX induced no current per se at concentrations up to 10 microM.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	95-98
11435748-8	2001	Capsaicin-induced desensitization also resulted in significantly higher plasma levels of IL-6 and TNF 1 but not 4 h after LPS challenge.	Capsaicin	0-9	tumor necrosis factor-like	Rattus norvegicus	98-101
11311802-7	2001	Rotenone, an inhibitor of complex I of the mitochondrial respiratory chain, and oligomycin, an inhibitor of F(0)F(1)-ATPase, significantly enhanced the mitochondrial depolarisation produced by capsaicin in DRG neurons.	Capsaicin	193-202	ATP synthase F1 subunit epsilon	Homo sapiens	108-123
11587561-4	2001	In an in vivo study exogenous as well as endogenous (capsaicin-induced) NKA increased airway opening pressure (P(ao)) and the exhaled NO level, and both were inhibited by an antagonist selective for NK(2) receptor (a receptor for NKA), SR48968.	Capsaicin	53-62	substance-K receptor	Cavia porcellus	199-213
11564427-0	2001	NMDA or non-NMDA receptor antagonists attenuate increased Fos expression in spinal dorsal horn GABAergic neurons after intradermal injection of capsaicin in rats.	Capsaicin	144-153	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	58-61
11564427-5	2001	Western blots showed that Fos protein was increased on the ipsilateral side in spinal cord tissue 0.5 h after capsaicin injection.	Capsaicin	110-119	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-29
11564427-6	2001	Pretreatment with AP7 or CNQX caused a decrease in capsaicin-induced Fos expression.	Capsaicin	51-60	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	69-72
11564427-7	2001	Immunofluorescence double labeling showed that the proportion of Fos-positive GABAergic neuronal profiles was significantly increased following capsaicin injection (48.8+/-4.8%) compared to the vehicle injection (23.8+/-5.1%) in superficial laminae on the ipsilateral side in lumbosacral spinal cord (P<0.05).	Capsaicin	144-153	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	65-68
11564427-9	2001	The blockade of the capsaicin-evoked Fos staining was dose-dependent.	Capsaicin	20-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	37-40
11226681-1	2001	The cloning of the receptor for capsaicin, vanilloid receptor 1, has shown it to be non-selective cation channel with a high calcium permeability which can be opened by noxious heat as well as capsaicin.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	43-63
11226681-1	2001	The cloning of the receptor for capsaicin, vanilloid receptor 1, has shown it to be non-selective cation channel with a high calcium permeability which can be opened by noxious heat as well as capsaicin.	Capsaicin	193-202	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	43-63
11226681-2	2001	Here we compare the calcium signals produced by native and recombinant capsaicin receptors when activated by either heat or capsaicin by imaging intracellular calcium levels ([Ca2+](i)) in rat dorsal root ganglion neurons and Chinese hamster ovary cells transfected with the rat vanilloid receptor, vanilloid receptor 1.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	299-319
11226681-3	2001	Vanilloid receptor 1 transfected cells and a subset of dorsal root ganglion neurons responded to both capsaicin and to heating to 50 degrees C with rapid, substantial and reversible rises in [Ca2+](i).	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-20
11226681-9	2001	The competitive capsaicin antagonist capsazepine (10microM) abolished [Ca2+](i) increases stimulated by capsaicin in both dorsal root ganglion neurons and vanilloid receptor 1 transfected cells.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	155-175
11226681-11	2001	In vanilloid receptor 1 transfected cells, Ruthenium Red (10microM) blocked responses to both capsaicin and heat.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	3-23
11226681-13	2001	They show that heat and capsaicin responses mediated by native and recombinant capsaicin receptors are similar with respect to the characteristics and pharmacology examined, suggesting that expression of recombinant vanilloid receptor 1 in cell lines accurately reproduces the properties of the native receptor.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	216-236
11166474-1	2001	Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons, which express the high-affinity NGF receptor, trkA.	Capsaicin	88-97	nerve growth factor receptor	Homo sapiens	175-187
11166474-1	2001	Nerve growth factor (NGF) regulates the nociceptive properties including sensitivity to capsaicin of a subset of dorsal root ganglion neurons, which express the high-affinity NGF receptor, trkA.	Capsaicin	88-97	neurotrophic receptor tyrosine kinase 1	Homo sapiens	189-193
11166474-2	2001	Capsaicin sensitivity co-localizes with the expression of a cloned capsaicin receptor, vanilloid receptor type 1 (VR-1), which displays properties similar to the native capsaicin response.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-118
11166474-2	2001	Capsaicin sensitivity co-localizes with the expression of a cloned capsaicin receptor, vanilloid receptor type 1 (VR-1), which displays properties similar to the native capsaicin response.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-118
11166474-3	2001	To determine whether VR-1 mRNA levels are regulated by NGF, VR-1 mRNA levels and the ability to respond to capsaicin by release of the neuropeptide calcitonin gene related peptide (CGRP) were measured as a function of NGF concentration in cultures of adult dorsal root ganglion neurons.	Capsaicin	107-116	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-25
11166474-4	2001	NGF treatment increased both VR-1 mRNA expression and capsaicin evoked release of CGRP.	Capsaicin	54-63	calcitonin related polypeptide alpha	Homo sapiens	82-86
11140687-1	2000	The cloned (VR1) and native VRs are non-selective cation channels directly activated by harmful heat, extracellular protons and vanilloid compounds.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-15
11274715-0	2001	Involvement of spinal NK2 and NMDA receptors in aversive behavior induced by intra-arterial injection of capsaicin.	Capsaicin	105-114	tachykinin precursor 1	Homo sapiens	22-25
11292182-8	2000	Both capsaicin pretreatment and posttreatment blocked the following MCT-induced alterations: increases in lung SP and airway constriction; decreases in tracheal NEP activity and dynamic respiratory compliance.	Capsaicin	5-14	membrane metallo-endopeptidase	Rattus norvegicus	161-164
11269923-7	2000	Intravesical capsaicin or RTX decreased, in a similar way, the number of CGRP and SP-IR (immunoreactive) fibers coursing in the muscular layer and the mucosa.	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	73-77
11269923-13	2000	We conclude that intravesical capsaicin or RTX were equally effective in terms of reducing the number of SP and CGRP-IR fibers and increasing the volume threshold for reflex micturition.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	112-116
11102645-1	2000	The vanilloid receptor 1 (VR1) gene is responsible for both capsaicin-, and low threshold (LT) noxious heat-sensitivity in mammalian primary sensory neurons.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-24
11102645-1	2000	The vanilloid receptor 1 (VR1) gene is responsible for both capsaicin-, and low threshold (LT) noxious heat-sensitivity in mammalian primary sensory neurons.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-29
11102645-8	2000	These findings suggest that a VR1 homologue which lacks to sequence for capsaicin-sensitivity is possibly the LT noxious heat transducer in chicken.	Capsaicin	72-81	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-33
11090977-0	2000	Fos activation and upregulation of nicotinamide adenine dinucleotide phosphate diaphorase in the rat pituitary by acute capsaicin injection.	Capsaicin	120-129	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
11090977-2	2000	Compared with vehicle, capsaicin significantly activated Fos expression in the anterior and intermediate lobes.	Capsaicin	23-32	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	57-60
11090977-4	2000	Pretreatment of the animals with a specific NO synthase inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME), significantly attenuated the capsaicin-induced Fos expression in the anterior and intermediate lobes.	Capsaicin	145-154	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	163-166
11147679-7	2000	Our results indicate that the topical cutaneous application of the neuropeptide-releasing agent capsaicin resulted in increased ICAM-1 and VCAM-1 immunostaining of microvascular cells in the skin of human volunteers.	Capsaicin	96-105	intercellular adhesion molecule 1	Homo sapiens	128-134
11093931-5	2000	In isolated, vascularly perfused adrenal gland, splanchnic nerve stimulation (16 Hz) and capsaicin (10(-5) M) increased PACAP-(1-38) release (1.6-fold and 6-fold respectively, P = 0.02).	Capsaicin	89-98	adenylate cyclase activating polypeptide 1	Homo sapiens	120-125
11095706-0	2000	The activation mechanism of rat vanilloid receptor 1 by capsaicin involves the pore domain and differs from the activation by either acid or heat.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-52
11095706-1	2000	The recently cloned rat vanilloid receptor, VR1, can be activated by capsaicin, acid, and heat.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	44-47
11095706-4	2000	Three of the mutant channels are significantly more sensitive to capsaicin than is wild-type VR1, whereas none differed in their activation by acidic pH or temperature.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	93-96
11095706-7	2000	These data indicate that VR1 undergoes conformational changes upon capsaicin binding that it does not undergo in response to activation by protons or thermal stimuli.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	25-28
11147679-7	2000	Our results indicate that the topical cutaneous application of the neuropeptide-releasing agent capsaicin resulted in increased ICAM-1 and VCAM-1 immunostaining of microvascular cells in the skin of human volunteers.	Capsaicin	96-105	vascular cell adhesion molecule 1	Homo sapiens	139-145
11110827-17	2000	Our data suggest that, while activation of both group II and group III mGluRs can reverse capsaicin-induced central sensitization, it is the actions of group II mGluRs in particular that undergo significant functional changes during central sensitization because they modulate responses of sensitized STT cells but have no effect under control conditions.	Capsaicin	90-99	glutamate receptor, metabotropic 2	Mus musculus	71-77
11000490-0	2000	Capsaicin effects on brain-derived neurotrophic factor in rat dorsal root ganglia and spinal cord.	Capsaicin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	21-54
11125845-7	2000	Capsaicin inhibited lipid peroxidation and myeloperoxidase activity in ethanol-induced gastric mucosal lesion in a dose-dependent manner.	Capsaicin	0-9	myeloperoxidase	Rattus norvegicus	43-58
11125845-8	2000	Capsaicin also inhibited the expression of cyclooxygenase-2 in the gastric mucosal lesion.	Capsaicin	0-9	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	43-59
11081515-7	2000	In support of this conclusion, the CB1 antagonist SR141716A enhances capsaicin-evoked bronchospasm and cough.	Capsaicin	69-78	cannabinoid receptor 1	Homo sapiens	35-38
11501035-3	2000	Calcitonin gene-related peptide (CGRP), a principal transmitter of capsaicin-sensitive sensory nerves, is involved in the mediation of ischemic preconditioning, and CGRP-mediated ischemic preconditioning has been shown to protect the endothelial cells.	Capsaicin	67-76	calcitonin related polypeptide alpha	Homo sapiens	0-31
11501035-3	2000	Calcitonin gene-related peptide (CGRP), a principal transmitter of capsaicin-sensitive sensory nerves, is involved in the mediation of ischemic preconditioning, and CGRP-mediated ischemic preconditioning has been shown to protect the endothelial cells.	Capsaicin	67-76	calcitonin related polypeptide alpha	Homo sapiens	33-37
11501035-3	2000	Calcitonin gene-related peptide (CGRP), a principal transmitter of capsaicin-sensitive sensory nerves, is involved in the mediation of ischemic preconditioning, and CGRP-mediated ischemic preconditioning has been shown to protect the endothelial cells.	Capsaicin	67-76	calcitonin related polypeptide alpha	Homo sapiens	165-169
11015288-13	2000	Cefaclor delays gastric emptying via capsaicin-sensitive afferent pathways, which involve CCK-A receptor interaction.	Capsaicin	37-46	cholecystokinin A receptor	Rattus norvegicus	90-104
11029625-1	2000	The heat-transducing receptor VR1 cloned from rat sensory neurons can be activated by both noxious heat and capsaicin.	Capsaicin	108-117	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	30-33
11034409-6	2000	In the absence of extracellular Ca2+, the PAF-induced Ca2+ elevation was not inhibited by capsaicin because capsaicin only inhibited the Ca2+ influx from the extracellular space.	Capsaicin	108-117	PCNA clamp associated factor	Homo sapiens	42-45
11034409-11	2000	Both capsaicin and SK&F96365 also inhibited PAF-induced cytosolic superoxide generation in HL-60 cells differentiated by all-trans-retinoic acid.	Capsaicin	5-14	PCNA clamp associated factor	Homo sapiens	48-51
11034409-12	2000	Our data suggest that capsaicin exerts its anti-inflammatory effect by inhibiting SOCE elicited via PLC activation, which occurs upon PAF activation and results in the subsequent superoxide production.	Capsaicin	22-31	PCNA clamp associated factor	Homo sapiens	134-137
11000441-0	2000	Neonatal capsaicin treatment decreased substance P receptor immunoreactivity in lamina III neurons of the dorsal horn.	Capsaicin	9-18	tachykinin receptor 1	Rattus norvegicus	39-59
11188502-3	2000	Heteromeric P2X2/3 (P2X2 and P2X3) receptor is expressed in capsaicin-insensitive primary afferent fibers, and its activation leads to the generation of slow desensitizing currents and induction of mechanical allodynia.	Capsaicin	60-69	purinergic receptor P2X 2	Homo sapiens	12-18
11188502-3	2000	Heteromeric P2X2/3 (P2X2 and P2X3) receptor is expressed in capsaicin-insensitive primary afferent fibers, and its activation leads to the generation of slow desensitizing currents and induction of mechanical allodynia.	Capsaicin	60-69	purinergic receptor P2X 2	Homo sapiens	20-43
11167915-3	2000	Release of CGRP by capsaicin or by high potassium concentration was concentration-dependent and counteracted in calcium-free medium.	Capsaicin	19-28	calcitonin related polypeptide alpha	Homo sapiens	11-15
11060130-16	2000	A similar difference in calcium dependence of inactivation has been reported between heat-evoked and capsaicin-induced currents through the cloned capsaicin receptor channel VR1.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	174-177
11050376-1	2000	Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-123
11050376-1	2000	Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	125-129
11050376-1	2000	Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype.	Capsaicin	180-189	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-123
11050376-1	2000	Capsaicin, resiniferatoxin, protons or heat have been shown to activate an ion channel, termed the rat vanilloid receptor-1 (rVR1), originally isolated by expression cloning for a capsaicin sensitive phenotype.	Capsaicin	180-189	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	125-129
11050376-4	2000	Mammalian cells transfected with human VR1 respond to capsaicin with an increase in intracellular calcium.	Capsaicin	54-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	39-42
11029402-11	2000	Vasorelaxation in response to MMP-2 inhibition was abolished by CGRP[8-37], a selective CGRP receptor antagonist, and by capsaicin, which depletes arterial perivascular nerves of CGRP.	Capsaicin	121-130	matrix metallopeptidase 2	Homo sapiens	30-35
11034409-0	2000	Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production.	Capsaicin	0-9	PCNA clamp associated factor	Homo sapiens	19-45
11034409-2	2000	We studied the regulation of PAF activity by capsaicin in human promyelocytic leukemia HL-60 cells.	Capsaicin	45-54	PCNA clamp associated factor	Homo sapiens	29-32
11034409-3	2000	Capsaicin inhibited PAF-induced superoxide production in a concentration-dependent manner.	Capsaicin	0-9	PCNA clamp associated factor	Homo sapiens	20-23
11034409-4	2000	In addition to PAF, the fMLP- and extracellular ATP-induced superoxide productions were inhibited by capsaicin, whereas PMA-induced superoxide production was not affected.	Capsaicin	101-110	PCNA clamp associated factor	Homo sapiens	15-18
11034409-4	2000	In addition to PAF, the fMLP- and extracellular ATP-induced superoxide productions were inhibited by capsaicin, whereas PMA-induced superoxide production was not affected.	Capsaicin	101-110	formyl peptide receptor 1	Homo sapiens	24-28
11034409-5	2000	In the PAF-stimulated cytosolic Ca2+ increase, capsaicin inhibited in particular the sustained portion of the raised Ca2+ level without attenuation of the peak height.	Capsaicin	47-56	PCNA clamp associated factor	Homo sapiens	7-10
11068101-4	2000	These data indicate that amylin gastroprotection involves capsaicin-sensitive nerve fiber leading to CGRP-dependent gastric vasodilatory effect.	Capsaicin	58-67	islet amyloid polypeptide	Rattus norvegicus	25-31
11068101-4	2000	These data indicate that amylin gastroprotection involves capsaicin-sensitive nerve fiber leading to CGRP-dependent gastric vasodilatory effect.	Capsaicin	58-67	calcitonin-related polypeptide alpha	Rattus norvegicus	101-105
11000490-2	2000	The percentage of BDNF-immunoreactive neurons in the L5 DRG was found to increase significantly 1 day after capsaicin injection.	Capsaicin	108-117	brain-derived neurotrophic factor	Rattus norvegicus	18-22
11000490-8	2000	The mechanism by which capsaicin induces changes in expression of BDNF in DRG neurons and the functional significance of the rapid increase in BDNF levels in the DRG is discussed briefly.	Capsaicin	23-32	brain-derived neurotrophic factor	Rattus norvegicus	66-70
10986333-2	2000	In this study, we studied the effect of capsaicin-induced stress on the expression of the immediate-early genes (IEGs) NGFI-A, -B, -C, egr-2, -3 and Nurr1 in the rat adrenal gland using in situ hybridization.	Capsaicin	40-49	early growth response 1	Rattus norvegicus	119-144
10986333-2	2000	In this study, we studied the effect of capsaicin-induced stress on the expression of the immediate-early genes (IEGs) NGFI-A, -B, -C, egr-2, -3 and Nurr1 in the rat adrenal gland using in situ hybridization.	Capsaicin	40-49	nuclear receptor subfamily 4, group A, member 2	Rattus norvegicus	149-154
11024569-2	2000	The potentiating effect induced by the co-injection of ip CCK and leptin to inhibit food consumption in mice is mediated by the CCK-A receptor and capsaicin sensitive afferents.	Capsaicin	147-156	cholecystokinin	Mus musculus	58-61
10996146-3	2000	CCK-induced activation of hindbrain neurons is mediated by capsaicin-sensitive vagal fibers.	Capsaicin	59-68	cholecystokinin	Rattus norvegicus	0-3
10996146-7	2000	CCK-induced Fos expression was abolished or attenuated in the brains of vagotomized or capsaicin-treated animals.	Capsaicin	87-96	cholecystokinin	Rattus norvegicus	0-3
10996146-7	2000	CCK-induced Fos expression was abolished or attenuated in the brains of vagotomized or capsaicin-treated animals.	Capsaicin	87-96	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	12-15
10995844-0	2000	Enhanced phosphorylation of NMDA receptor 1 subunits in spinal cord dorsal horn and spinothalamic tract neurons after intradermal injection of capsaicin in rats.	Capsaicin	143-152	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	28-43
11016864-6	2000	In capsaicin-treated group of rats, we observed the increase in PBF by 44% and in serum Il-1beta concentration by 91%.	Capsaicin	3-12	interleukin 1 beta	Rattus norvegicus	88-96
11016864-8	2000	In rats treated with CGRP the alterations in PBF, serum Il-1beta concentration, as well as, in pancreatic and fecal activity of enzymes were similar to capsaicin treated group but less pronounced.	Capsaicin	152-161	calcitonin-related polypeptide alpha	Rattus norvegicus	21-25
11024569-2	2000	The potentiating effect induced by the co-injection of ip CCK and leptin to inhibit food consumption in mice is mediated by the CCK-A receptor and capsaicin sensitive afferents.	Capsaicin	147-156	leptin	Mus musculus	66-72
10899285-2	2000	Here we demonstrate with the use of in vivo microdialysis and radioimmunoassay techniques that SP is also released within trigeminal ganglia following intraganglionic application of KCl, veratridine or capsaicin, and after electrical stimulation of peripheral afferent fibers.	Capsaicin	202-211	tachykinin precursor 1	Homo sapiens	95-97
10940371-2	2000	The opioid receptor-like 1 (ORL1) receptor agonist, nociceptin/orphanin FQ (0.001-1 microM) produced a dose-related inhibition of the capsaicin-induced bronchoconstriction (10(-5)-10(3) microg) in isolated guinea pig lung (P<0.05), a response mediated by the release of endogenous tachykinins from lung sensory nerves.	Capsaicin	134-143	nociceptin receptor	Cavia porcellus	4-26
10940371-2	2000	The opioid receptor-like 1 (ORL1) receptor agonist, nociceptin/orphanin FQ (0.001-1 microM) produced a dose-related inhibition of the capsaicin-induced bronchoconstriction (10(-5)-10(3) microg) in isolated guinea pig lung (P<0.05), a response mediated by the release of endogenous tachykinins from lung sensory nerves.	Capsaicin	134-143	nociceptin receptor	Cavia porcellus	28-32
10880996-3	2000	Subcutaneous capsaicin injection in male rats, compared with vehicle, caused a significant increase in Fos expression in the paraventricular nucleus (PVN), supraoptic nucleus (SON), and medial and cortical amygdala.	Capsaicin	13-22	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-106
10880996-6	2000	A higher proportion of the NOS neurons in the PVN, periventricular region, SON and amygdala showed Fos expression in response to capsaicin than vehicle injection.	Capsaicin	129-138	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	99-102
10920204-6	2000	In knockout mice lacking synapsin I and II, sensory nerve endings are normally developed but not stimulated by CsA whereas a control stimulus, capsaicin, is fully active.	Capsaicin	143-152	synapsin I	Mus musculus	25-42
10899177-0	2000	Mechanical allodynia caused by intraplantar injection of P2X receptor agonist in rats: involvement of heteromeric P2X2/3 receptor signaling in capsaicin-insensitive primary afferent neurons.	Capsaicin	143-152	purinergic receptor P2X 2	Rattus norvegicus	114-120
10899177-8	2000	Taken together with our previous finding that the alpha(beta)meATP-activated slow desensitizing current in DRG neurons is mediated by heteromeric P2X2/3 (P2X2 and P2X3) receptors, it is hypothesized that activation of heteromeric P2X2/3 receptors in peripheral terminals of capsaicin-insensitive primary afferent fibers leads to the induction of mechanical allodynia.	Capsaicin	274-283	purinergic receptor P2X 2	Rattus norvegicus	146-152
10899177-8	2000	Taken together with our previous finding that the alpha(beta)meATP-activated slow desensitizing current in DRG neurons is mediated by heteromeric P2X2/3 (P2X2 and P2X3) receptors, it is hypothesized that activation of heteromeric P2X2/3 receptors in peripheral terminals of capsaicin-insensitive primary afferent fibers leads to the induction of mechanical allodynia.	Capsaicin	274-283	purinergic receptor P2X 2	Rattus norvegicus	154-167
10976461-0	2000	[The effect of anti-NGF and NGF on the responses to noxious heat in mice treated with capsaicin in the neonatal period].	Capsaicin	86-95	nerve growth factor	Mus musculus	15-31
10976461-7	2000	Withdrawal latencies of the mice treated with both capsaicin and anti-NGF were significantly retarded compared with those of the animals treated with only capsaicin.	Capsaicin	155-164	nerve growth factor	Mus musculus	70-73
10976461-9	2000	On the other hand, the latencies of the mice treated with both capsaicin and NGF were short compared with those of the animals treated with only capsaicin.	Capsaicin	145-154	nerve growth factor	Mus musculus	77-80
10884527-0	2000	Systemic anti-inflammatory effect of somatostatin released from capsaicin-sensitive vagal and sciatic sensory fibres of the rat and guinea-pig.	Capsaicin	64-73	somatostatin	Rattus norvegicus	37-49
10884527-6	2000	It is concluded that somatostatin released from the activated vagal capsaicin-sensitive sensory nerve terminals of the rat and somatic nerves of the guinea-pigs exerts a systemic humoral function.	Capsaicin	68-77	somatostatin	Rattus norvegicus	21-33
10896894-8	2000	Pretreatment with capsaicin significantly reduced the number of Fos-IR cells induced by bladder distension after SCI.	Capsaicin	18-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-67
10859346-2	2000	The response of VR1 to capsaicin or noxious heat is dynamically potentiated by extracellular protons within a pH range encountered during tissue acidosis, such as that associated with arthritis, infarction, tumor growth, and other forms of injury.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-19
10896894-9	2000	These data suggest that SCI can reveal an altered Fos expression pattern in response to a nonnoxious bladder stimulus that is partially mediated by capsaicin-sensitive bladder afferents.	Capsaicin	148-157	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-53
10998535-5	2000	nociceptin inhibits the micturition reflex by inhibiting afferent discharge from capsaicin-sensitive nerves.	Capsaicin	81-90	prepronociceptin	Rattus norvegicus	0-10
10932322-0	2000	Distribution of capsaicin-sensitive substance P- and calcitonin gene-related peptide-immunoreactive nerves in bovine respiratory tract.	Capsaicin	16-25	tachykinin precursor 1	Bos taurus	36-47
10882393-14	2000	In preparations without endothelium, treatment with capsaicin (depleting CGRP-containing sensory nerves, 1 microM) or human CGRP[8 - 37] (CGRP receptor antagonist, 0.5 microM) markedly inhibited the nicotine-induced vasodilation.	Capsaicin	52-61	calcitonin related polypeptide alpha	Homo sapiens	73-77
10903936-1	2000	BACKGROUND: Vanilloids, such as capsaicin and resiniferatoxin (RTX), are recognized at the cell surface by vanilloid receptor type 1 (VR1), which has recently been cloned.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-137
10903936-2	2000	VR1 mediates the effects of capsaicin and RTX in VR1-expressing cells, but vanilloids can induce apoptosis through a pathway not mediated by VR1.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-3
10903936-2	2000	VR1 mediates the effects of capsaicin and RTX in VR1-expressing cells, but vanilloids can induce apoptosis through a pathway not mediated by VR1.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-52
10903936-2	2000	VR1 mediates the effects of capsaicin and RTX in VR1-expressing cells, but vanilloids can induce apoptosis through a pathway not mediated by VR1.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-52
10828491-6	2000	Moreover, intravenous infusion of CGRP antagonist blocked the inhibitory effect of intraluminal capsaicin perfusion on alanine absorption.	Capsaicin	96-105	calcitonin-related polypeptide alpha	Rattus norvegicus	34-38
10852778-8	2000	These results suggest that NGF not only increases SP expression in airway neurons, but changes the neuronal phenotype such that large, capsaicin-insensitive nodose neurons with fast-conducting "Adelta" fibers provide a component of the tachykinergic innervation.	Capsaicin	135-144	beta-nerve growth factor	Cavia porcellus	27-30
10856126-1	2000	Whole-cell voltage-clamp techniques were used to investigate the capsaicin-, voltage- and time-dependent properties of the rat vanilloid receptor (rVR1) stably expressed in human embryonic kidney (HEK) 293 cells.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	147-151
10856126-2	2000	At a holding potential of -70 mV, application of capsaicin (0.03-30 microM) to HEK 293 cells expressing the rVR1 receptor led to the appearance of inward currents (EC50, 497 nM; Hill coefficient, nH, 2.85) which were reversibly antagonized by 10 microM capsazepine.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	108-112
10837823-1	2000	Isoprostane E(2) (8-iso-PGE) and F(2alpha) (8-iso-PGF) sensitize nociceptors and capsaicin-sensitive DRG neurons.	Capsaicin	81-90	placental growth factor	Rattus norvegicus	50-53
10864900-7	2000	Capsazepine, isovelleral and ruthenium red all inhibited the capsaicin (100 nM)-induced Ca(2+) response in rVR1-HEK293 cells, with pK(B) values of 7.52+/-0.08, 6.92+/-0.11 and 8.09+/-0.12 respectively (n=6 each).	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	107-111
10883379-8	2000	During repetitive tactile stimulation plus capsaicin, the duration of ES1 and ES2 was shortened (ES1 and ES2: P < 0.001) and the degree of suppression was reduced (ES1: P < 0.05; ES2: P < 0.005).	Capsaicin	43-52	glutamine amidotransferase class 1 domain containing 3	Homo sapiens	70-73
10877240-1	2000	We examined the role of capsaicin-sensitive afferent neurons in pH-dependent gastrin secretion in the rat stomach.	Capsaicin	24-33	gastrin	Rattus norvegicus	77-84
10877240-4	2000	Capsaicin pretreatment (125 mg/kg subcutaneously over two days) inhibited the change in serum gastrin levels both the luminal alkalization (38%) and acidification (66%).	Capsaicin	0-9	gastrin	Rattus norvegicus	94-101
10877240-6	2000	Our results indicate that capsaicin-sensitive afferent neurons participate in the secretion of gastrin by luminal alkalization and inhibition of gastrin by luminal acidification.	Capsaicin	26-35	gastrin	Rattus norvegicus	95-102
10877240-6	2000	Our results indicate that capsaicin-sensitive afferent neurons participate in the secretion of gastrin by luminal alkalization and inhibition of gastrin by luminal acidification.	Capsaicin	26-35	gastrin	Rattus norvegicus	145-152
10883379-8	2000	During repetitive tactile stimulation plus capsaicin, the duration of ES1 and ES2 was shortened (ES1 and ES2: P < 0.001) and the degree of suppression was reduced (ES1: P < 0.05; ES2: P < 0.005).	Capsaicin	43-52	ess-2 splicing factor homolog	Homo sapiens	78-81
10883379-8	2000	During repetitive tactile stimulation plus capsaicin, the duration of ES1 and ES2 was shortened (ES1 and ES2: P < 0.001) and the degree of suppression was reduced (ES1: P < 0.05; ES2: P < 0.005).	Capsaicin	43-52	glutamine amidotransferase class 1 domain containing 3	Homo sapiens	97-100
10883379-8	2000	During repetitive tactile stimulation plus capsaicin, the duration of ES1 and ES2 was shortened (ES1 and ES2: P < 0.001) and the degree of suppression was reduced (ES1: P < 0.05; ES2: P < 0.005).	Capsaicin	43-52	ess-2 splicing factor homolog	Homo sapiens	105-108
10883379-8	2000	During repetitive tactile stimulation plus capsaicin, the duration of ES1 and ES2 was shortened (ES1 and ES2: P < 0.001) and the degree of suppression was reduced (ES1: P < 0.05; ES2: P < 0.005).	Capsaicin	43-52	glutamine amidotransferase class 1 domain containing 3	Homo sapiens	97-100
10883379-8	2000	During repetitive tactile stimulation plus capsaicin, the duration of ES1 and ES2 was shortened (ES1 and ES2: P < 0.001) and the degree of suppression was reduced (ES1: P < 0.05; ES2: P < 0.005).	Capsaicin	43-52	ess-2 splicing factor homolog	Homo sapiens	105-108
10869604-0	2000	Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	104-107
10821274-2	2000	VR1 responds to noxious stimuli including capsaicin, the pungent component of chilli peppers, heat and extracellular acidification, and it is able to integrate simultaneous exposure to these stimuli.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-3
10821274-3	2000	These findings and research linking capsaicin with nociceptive behaviours (that is, responses to painful stimuli in animals have led to VR1 being considered as important for pain sensation.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	136-139
10821274-5	2000	Small diameter dorsal root ganglion neurons isolated from VR1-null mice lacked many of the capsaicin-, acid- and heat-gated responses that have been previously well characterized in small diameter dorsal root ganglion neurons from various species.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	58-61
10837892-2	2000	Capsaicin-induced destruction of C fibres was confirmed by 62% loss of Isolectin B4 (IB4)-binding and an 86% loss of calcitonin gene-related peptide (CGRP)-immunoreactive small diameter dorsal root ganglion cells.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	117-148
10837892-2	2000	Capsaicin-induced destruction of C fibres was confirmed by 62% loss of Isolectin B4 (IB4)-binding and an 86% loss of calcitonin gene-related peptide (CGRP)-immunoreactive small diameter dorsal root ganglion cells.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	150-154
10742536-4	2000	The results showed that activation of airway sensory receptors, by inhalation of aerosolized histamine or capsaicin, induced cFos expression in a subset of nTS neurons that also expressed the AMPA subtype of glutamate receptors.	Capsaicin	106-115	neurotensin/neuromedin N	Mustela putorius furo	156-159
10764638-2	2000	Heterologously expressed VR1 can be activated by vanilloid compounds, protons, or heat (>43 degrees C), but whether this channel contributes to chemical or thermal sensitivity in vivo is not known.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-28
10807415-10	2000	CONCLUSIONS: The results suggest that the inhibition of ethanol-induced gastric injury by capsaicin is attributable to the suppression of collecting venule constriction, via CGRP release.	Capsaicin	90-99	calcitonin-related polypeptide alpha	Rattus norvegicus	174-178
10760483-3	2000	Our results indicate that capsaicin (1 microM)-evoked release of immunoreactive calcitonin gene-related peptide (iCGRP) is significantly reduced in the presence of the NO synthase inhibitor, L-NAME (10-400 nM; F(3,45)=68.38; P<0.001) and, the selective nNOS inhibitor, 3-bromo-7-nitroindazole (170-680 nM; F(5,48)=56.2; P<0.	Capsaicin	26-35	nitric oxide synthase 1	Homo sapiens	256-260
10760483-12	2000	Additionally, our results demonstrate that while capsaicin-evoked release is significantly reduced in the presence of LY-83583 (10 microM; F(2,18)=3.46; P<0.01; a cyclic GMP lowering agent), there is no effect of ODQ (a potent and selective inhibitor of guanylate cyclase).	Capsaicin	49-58	5'-nucleotidase, cytosolic II	Homo sapiens	173-176
10807415-1	2000	BACKGROUND: Capsaicin acts specifically on primary afferent neurones to release neuropeptides, including calcitonin gene-related peptide (CGRP), and prevents ethanol-induced mucosal injury.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	105-136
10749792-7	2000	Pretreatment with capsaicin significantly reduced the number of Fos-IR cells induced by bladder distension after cystitis.	Capsaicin	18-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-67
10807415-1	2000	BACKGROUND: Capsaicin acts specifically on primary afferent neurones to release neuropeptides, including calcitonin gene-related peptide (CGRP), and prevents ethanol-induced mucosal injury.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	138-142
10807415-9	2000	Prior application of capsaicin prevented ethanol-induced constriction of the collecting venules, and the action of capsaicin was inhibited by prior application of CGRP-(8-37).	Capsaicin	115-124	calcitonin-related polypeptide alpha	Rattus norvegicus	163-167
10781907-10	2000	Finally, evidence that reduction in grip force is in part mediated by small, unmyelinated afferents is provided by the demonstration that neonatal capsaicin treatment significantly reduced carrageenan-evoked behavioral hyperalgesia ( approximately 45% reduction) and reduced muscle content of immunoreactive CGRP ( approximately 60% reduction) relative to control levels.	Capsaicin	147-156	calcitonin related polypeptide alpha	Homo sapiens	308-312
10759257-7	2000	WRS alone caused a significant reduction (by 52% and -35%, respectively) in gastric and duodenal CGRP content, which was prevented by acute capsaicin treatment.	Capsaicin	140-149	calcitonin-related polypeptide alpha	Rattus norvegicus	97-101
10771495-9	2000	Capsaicin pretreatment blocked AA-induced Fos in all structures tested.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	42-45
10727645-0	2000	The effect of neonatal capsaicin on the c-Fos-like immunoreactivity induced in subnucleus oralis neurons by noxious intraoral stimulation.	Capsaicin	23-32	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	40-45
11961588-0	2000	[Increased expression of c-fos in the brainstem nuclei involved in cardiova scular regulation by capsaicin].	Capsaicin	97-106	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	25-30
11961588-1	2000	Effects of intracarotid injected capsaicin on the expression of Fos proto-oncogene in the brainstem nuclei involved in cardiovascular regulation were examined in 16 anesthetized rats with sinoaortic denervation.	Capsaicin	33-42	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	64-67
11961588-4	2000	The excitatory response to intracarotid injection of capsaicin was significantly inhibited by pretreatment with the vanilloid receptor (capsaicin receptor) antagonist ruthenium red (200 mmol, 0.1 ml).	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-154
10727645-2	2000	The induction of Fos-LI by topical capsaicin application to the lingual mucosal stimulation was almost completely suppressed by neonatal capsaicin treatment.	Capsaicin	35-44	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-20
10727645-2	2000	The induction of Fos-LI by topical capsaicin application to the lingual mucosal stimulation was almost completely suppressed by neonatal capsaicin treatment.	Capsaicin	137-146	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-20
10696096-1	2000	Endothelin-1 causes ET(A) receptor-mediated enhancement of capsaicin-induced nociception in mice.	Capsaicin	59-68	endothelin 1	Mus musculus	0-12
10725386-7	2000	In the central nervous system, neonatal capsaicin treatment depleted VR1 mRNA from the spinal nucleus of the trigeminal nerve, but not from other areas such as the inferior olive.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-72
11210723-8	2000	It is concluded that stimulation of EGF expression in salivary glands and serum may be one of the mechanisms by which capsaicin sensitive nerves contribute to the gastroprotective and ulcer healing actions in the stomach.	Capsaicin	118-127	epidermal growth factor like 1	Rattus norvegicus	36-39
10725261-14	2000	The destruction of capsaicin-sensitive afferents appears to sensitize the NTS to SP, NKB, [Sar(9),Met(O(2))(11)]-SP, senktide and [Nle(10)]-NKA(4-10).	Capsaicin	19-28	Natural killer alloreactivity QTL 1	Rattus norvegicus	140-143
10671875-8	2000	In hyper-reflexic patients who responded to capsaicin by improved bladder capacity, the mean nerve density of S100-positive structures was reduced from 100 (12.2) before to 66 (9.4) nerves/mm2 6 weeks after treatment.	Capsaicin	44-53	S100 calcium binding protein A1	Homo sapiens	110-114
10671875-8	2000	In hyper-reflexic patients who responded to capsaicin by improved bladder capacity, the mean nerve density of S100-positive structures was reduced from 100 (12.2) before to 66 (9.4) nerves/mm2 6 weeks after treatment.	Capsaicin	44-53	PNMA family member 2	Homo sapiens	189-192
10620629-7	2000	Nuclear translocation of transcription factor NF-kappaB was monitored by immunofluorescence and inhibited by (E)-capsaicin.	Capsaicin	109-122	nuclear factor kappa B subunit 1	Homo sapiens	46-55
10644739-2	2000	Recently a cDNA clone, vanilloid receptor subtype-1 (VR1), was isolated and found to encode an ion channel that is activated by both capsaicin, the pain producing compound in chili peppers, and by noxious thermal stimuli.	Capsaicin	133-142	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-56
10653024-3	2000	Intravenous injection of the putative mediator somatostatin (10 microg/kg) or its analogues RC-160 and TT-232, but not octreotide inhibited the cardiorespiratory and blood pressure responses evoked by topical cutaneous application of mustard oil or capsaicin instillation into the eye.	Capsaicin	249-258	somatostatin	Rattus norvegicus	47-59
10674828-5	2000	This effect could be inhibited by repeated pretreatment of the skin with topical capsaicin, a chemical that results in the release of substance P from peripheral nerve endings.	Capsaicin	81-90	tachykinin precursor 1	Homo sapiens	134-145
10647701-23	2000	The effects observed after the intravenous administration of nociceptin indicate that the functional integrity of capsaicin-sensitive bladder afferents is required for exerting its inhibitory activity at the peripheral level.	Capsaicin	114-123	prepronociceptin	Rattus norvegicus	61-71
10650165-7	2000	Owing to the connection between capsaicin and calcitonin gene-related peptide (CGRP), a possible effect of MED15 on CGRP receptors was hypothesized, considering the leading role played on gastric mucosa by the predominant sensory neuropeptide of the stomach wall, CGRP.	Capsaicin	32-41	mediator complex subunit 15	Rattus norvegicus	107-112
10620629-10	2000	Activation of surface protein CD40 increased Bcl-x(L) protein levels via an (E)-capsaicin-inhibitable activation of NF-kappaB; i.e. , (E)-capsaicin restored etoposide sensitivity.	Capsaicin	76-89	CD40 molecule	Homo sapiens	30-34
10620629-10	2000	Activation of surface protein CD40 increased Bcl-x(L) protein levels via an (E)-capsaicin-inhibitable activation of NF-kappaB; i.e. , (E)-capsaicin restored etoposide sensitivity.	Capsaicin	76-89	BCL2 like 1	Homo sapiens	45-53
10620629-10	2000	Activation of surface protein CD40 increased Bcl-x(L) protein levels via an (E)-capsaicin-inhibitable activation of NF-kappaB; i.e. , (E)-capsaicin restored etoposide sensitivity.	Capsaicin	76-89	nuclear factor kappa B subunit 1	Homo sapiens	116-125
10620629-10	2000	Activation of surface protein CD40 increased Bcl-x(L) protein levels via an (E)-capsaicin-inhibitable activation of NF-kappaB; i.e. , (E)-capsaicin restored etoposide sensitivity.	Capsaicin	134-147	CD40 molecule	Homo sapiens	30-34
10620629-10	2000	Activation of surface protein CD40 increased Bcl-x(L) protein levels via an (E)-capsaicin-inhibitable activation of NF-kappaB; i.e. , (E)-capsaicin restored etoposide sensitivity.	Capsaicin	134-147	BCL2 like 1	Homo sapiens	45-53
10620629-10	2000	Activation of surface protein CD40 increased Bcl-x(L) protein levels via an (E)-capsaicin-inhibitable activation of NF-kappaB; i.e. , (E)-capsaicin restored etoposide sensitivity.	Capsaicin	134-147	nuclear factor kappa B subunit 1	Homo sapiens	116-125
11216470-0	2000	Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.	Capsaicin	35-44	nuclear factor kappa B subunit 1	Homo sapiens	118-127
11268370-4	2000	Here we show that neuropeptide input to the bone marrow is vital to normal granulopoiesis and that deletion of the neuropeptides, substance P, and calcitonin gene-related peptide (CGRP), with the neurotoxin, capsaicin, abrogates normal blood cell production.	Capsaicin	208-217	calcitonin related polypeptide alpha	Homo sapiens	147-178
11268370-4	2000	Here we show that neuropeptide input to the bone marrow is vital to normal granulopoiesis and that deletion of the neuropeptides, substance P, and calcitonin gene-related peptide (CGRP), with the neurotoxin, capsaicin, abrogates normal blood cell production.	Capsaicin	208-217	calcitonin related polypeptide alpha	Homo sapiens	180-184
11216470-0	2000	Inhibitory effects of curcumin and capsaicin on phorbol ester-induced activation of eukaryotic transcription factors, NF-kappaB and AP-1.	Capsaicin	35-44	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	132-136
11216470-9	2000	Based on these findings, it is likely that curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation of transcription factors, NF-kappaB and AP-1.	Capsaicin	56-65	nuclear factor kappa B subunit 1	Homo sapiens	190-199
11216470-9	2000	Based on these findings, it is likely that curcumin and capsaicin exert anti-tumor promotional effects through suppression of the tumor promoter-induced activation of transcription factors, NF-kappaB and AP-1.	Capsaicin	56-65	JunB proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	204-208
10694225-2	2000	Further electrophysiological studies showed that anandamide (10 or 100 microM) and capsaicin (1 microM) produced similar inward currents in hVR1 transfected, but not in parental, HEK293 cells.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	140-144
10651737-4	2000	Deletion of the neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP) by capsaicin abrogates normal blood cell production.	Capsaicin	94-103	tachykinin precursor 1	Homo sapiens	31-42
10694225-4	2000	In the FLIPR anandamide and capsaicin were full agonists at hVR1, with pEC(50) values of 5.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-64
10651737-4	2000	Deletion of the neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP) by capsaicin abrogates normal blood cell production.	Capsaicin	94-103	calcitonin related polypeptide alpha	Homo sapiens	52-83
11025360-22	2000	The protective and hyperemic effects of centrally administered leptin were abolished by vagotomy, producing a fall in plasma leptin levels, and significantly attenuated by sensory denervation with capsaicin, by pretreatment with the CGRP antagonist, CGRP(8-37), or with L-NAME.	Capsaicin	197-206	leptin	Rattus norvegicus	63-69
10651737-4	2000	Deletion of the neuropeptides, substance P (SP) and calcitonin gene-related peptide (CGRP) by capsaicin abrogates normal blood cell production.	Capsaicin	94-103	calcitonin related polypeptide alpha	Homo sapiens	85-89
10654070-8	2000	Neonatal capsaicin reduced the PACAP-38 concentration by approximately 50%, and accordingly a marked reduction in PACAP/CGRP-immunoreactive nerve fibres in the exocrine and endocrine pancreas was observed.	Capsaicin	9-18	adenylate cyclase activating polypeptide 1	Rattus norvegicus	31-36
10654070-8	2000	Neonatal capsaicin reduced the PACAP-38 concentration by approximately 50%, and accordingly a marked reduction in PACAP/CGRP-immunoreactive nerve fibres in the exocrine and endocrine pancreas was observed.	Capsaicin	9-18	adenylate cyclase activating polypeptide 1	Rattus norvegicus	114-119
10654070-8	2000	Neonatal capsaicin reduced the PACAP-38 concentration by approximately 50%, and accordingly a marked reduction in PACAP/CGRP-immunoreactive nerve fibres in the exocrine and endocrine pancreas was observed.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	120-124
10671773-11	2000	Both lafutidine and capsaicin significantly suppressed the increases in MPO and iNOS activities as well as enterobacterial numbers in the mucosa.	Capsaicin	20-29	myeloperoxidase	Rattus norvegicus	72-75
10671773-11	2000	Both lafutidine and capsaicin significantly suppressed the increases in MPO and iNOS activities as well as enterobacterial numbers in the mucosa.	Capsaicin	20-29	nitric oxide synthase 2	Rattus norvegicus	80-84
11025360-22	2000	The protective and hyperemic effects of centrally administered leptin were abolished by vagotomy, producing a fall in plasma leptin levels, and significantly attenuated by sensory denervation with capsaicin, by pretreatment with the CGRP antagonist, CGRP(8-37), or with L-NAME.	Capsaicin	197-206	calcitonin-related polypeptide alpha	Rattus norvegicus	233-237
10662894-5	2000	CGRP-IR and SP-IR fibres were significantly reduced in numbers by the capsaicin treatment (by 58 and 49%, respectively), confirming the success of sensory denervation.	Capsaicin	70-79	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
10651868-6	2000	Systemic treatment with the NGF-sequestering fusion protein trkA-IgG significantly inhibited electrically or capsaicin-evoked SP release without affecting basal outflow and SP content in spinal cord and sciatic nerve.	Capsaicin	109-118	nerve growth factor	Rattus norvegicus	28-31
10651868-6	2000	Systemic treatment with the NGF-sequestering fusion protein trkA-IgG significantly inhibited electrically or capsaicin-evoked SP release without affecting basal outflow and SP content in spinal cord and sciatic nerve.	Capsaicin	109-118	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	60-64
11200362-8	2000	It was found that the acute topical application of RA (0.9 mg/mouse) or capsaicin (0.09 mg/mouse) significantly increased the mouse paw oedema induced by carrageenan, while an 8-day repeated topical treatment with the same doses of both compounds resulted in a marked inhibition of carrageenan-induced paw oedema matched by a reduction in SP tissue levels.	Capsaicin	72-81	tachykinin 1	Mus musculus	339-341
11251391-8	2000	In capsaicin-treated infected rats, the MPO increase at day 12 was augmented, and MPO was still not returned to preinfection values by day 35; in contrast, the increase of mast cell numbers at days 12 and 35 was not modified by afferent nerve depletion.	Capsaicin	3-12	myeloperoxidase	Rattus norvegicus	40-43
11251391-8	2000	In capsaicin-treated infected rats, the MPO increase at day 12 was augmented, and MPO was still not returned to preinfection values by day 35; in contrast, the increase of mast cell numbers at days 12 and 35 was not modified by afferent nerve depletion.	Capsaicin	3-12	myeloperoxidase	Rattus norvegicus	82-85
10658634-6	2000	Pretreatment of the nerve to be lesioned with capsaicin was sufficient to significantly attenuate the changes in the plasma extravasation response and substance P content observed on the contralateral side.	Capsaicin	46-55	tachykinin precursor 1	Homo sapiens	151-162
10854767-5	2000	In contrast, NK1 -/- mice showed profound deficits in spontaneous behavioural reactions to an acute visceral chemical stimulus (intracolonic capsaicin) and failed to develop referred hyperalgesia or tissue oedema.	Capsaicin	141-150	tachykinin 1	Mus musculus	13-16
10771345-9	2000	Taken together, these results demonstrate that capsaicin-sensitive primary afferent fibers are involved not only in thermal hyperalgesia but also in tactile allodynia induced by nociceptin, but in different pathways; the former is mediated by substance P and the latter is mediated by glutamate through the N-methyl-D-aspartate receptor comprising the GluRvarepsilon1 subunit.	Capsaicin	47-56	tachykinin 1	Mus musculus	243-254
10683575-2	2000	We found that Fos expression is increased after intradermal capsaicin injection, which also leads to endogenous nitric oxide release in the spinal cord.	Capsaicin	60-69	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
10683575-9	2000	These results suggest that nitric oxide helps mediate Fos expression induced by an intradermal capsaicin injection.	Capsaicin	95-104	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-57
10619474-0	2000	Mitochondrial calcium accumulation following activation of vanilloid (VR1) receptors by capsaicin in dorsal root ganglion neurons.	Capsaicin	88-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	70-73
10619474-1	2000	Stimulation of the vanilloid (capsaicin) receptor (VR1), currently viewed as a molecular integrator of chemical and physical noxious stimuli, evoked intracellular Ca2+ transients in a capsaicin-sensitive subpopulation of rat dorsal root ganglion neurons.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-54
10619474-9	2000	The long duration of intracellular Ca2+ decline in neurons stimulated with capsaicin, which depends on the amount of Ca2+ buffered by mitochondria, may reflect a specific mechanism of Ca2+ buffering following activation the pain receptor VR1.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	238-241
10594048-7	1999	We conclude that distinct molecular entities, which are both likely to be derived from the VR1 gene product, account for the membrane responses to heat and capsaicin.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-94
10629436-1	2000	A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-related peptide (CGRP), substance P and neurokinin A.	Capsaicin	19-28	calcitonin related polypeptide alpha	Homo sapiens	74-105
10629436-1	2000	A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-related peptide (CGRP), substance P and neurokinin A.	Capsaicin	19-28	calcitonin related polypeptide alpha	Homo sapiens	107-111
10629436-1	2000	A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-related peptide (CGRP), substance P and neurokinin A.	Capsaicin	19-28	tachykinin precursor 1	Homo sapiens	114-125
10629436-1	2000	A subpopulation of capsaicin-sensitive cardiac C-fibre afferents co-store calcitonin gene-related peptide (CGRP), substance P and neurokinin A.	Capsaicin	19-28	tachykinin precursor 1	Homo sapiens	130-142
10602329-15	1999	These findings suggest that spinal endogenous ATP may play a role in (1) the formalin- and capsaicin-induced neurogenic pain via the PPADS- and TNP-ATP-sensitive P2X receptors which are also desensitized by alpha,betameATP (perhaps the P2X3 receptor subtype) and (2) formalin-induced inflammatory pain via PPADS-sensitive, TNP-ATP- and alpha,betameATP-insensitive P2X (and/or P2Y) receptors.	Capsaicin	91-100	purinergic receptor P2X, ligand-gated ion channel, 3	Mus musculus	236-240
10605941-0	1999	Nerve growth factor stimulates synthesis of calcitonin gene-related peptide in dorsal root ganglion cells during sensory regeneration in capsaicin-treated rats.	Capsaicin	137-146	nerve growth factor	Rattus norvegicus	0-19
10626851-14	1999	After capsaicin pretreatment, contractions increased to 59% with CGRP (P = .002).	Capsaicin	6-15	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
10524715-3	1999	The selective NMDA glutamate receptor agonist L-CCG-IV (1-10 microM) enhanced capsaicin-evoked substance P release about 100%.	Capsaicin	78-87	glutamate ionotropic receptor NMDA type subunit 2C	Rattus norvegicus	14-37
10605941-0	1999	Nerve growth factor stimulates synthesis of calcitonin gene-related peptide in dorsal root ganglion cells during sensory regeneration in capsaicin-treated rats.	Capsaicin	137-146	calcitonin-related polypeptide alpha	Rattus norvegicus	44-75
10657523-6	1999	BEAS-2B cells also responded to the botanical irritant, capsaicin (10 microM) with increases in [Ca(2+)](i) and IL-8 cytokine release after 4 h exposure.	Capsaicin	56-65	C-X-C motif chemokine ligand 8	Homo sapiens	112-116
10605941-1	1999	Administration of human recombinant nerve growth factor (rhNGF) into one hindpaw of capsaicin-treated rats can locally facilitate the regeneration of calcitonin gene-related peptide (CGRP)-containing primary sensory neurons (Schicho, R., Skofitsch, G., Donnerer, J., 1999.	Capsaicin	84-93	nerve growth factor	Homo sapiens	36-55
10605941-1	1999	Administration of human recombinant nerve growth factor (rhNGF) into one hindpaw of capsaicin-treated rats can locally facilitate the regeneration of calcitonin gene-related peptide (CGRP)-containing primary sensory neurons (Schicho, R., Skofitsch, G., Donnerer, J., 1999.	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	150-181
10605941-1	1999	Administration of human recombinant nerve growth factor (rhNGF) into one hindpaw of capsaicin-treated rats can locally facilitate the regeneration of calcitonin gene-related peptide (CGRP)-containing primary sensory neurons (Schicho, R., Skofitsch, G., Donnerer, J., 1999.	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	183-187
10605941-5	1999	Whereas 8 days after the capsaicin treatment alone (50 mg/kg s.c.) CGRP mRNA expression in DRG cells was reduced to 40-60% of control levels, the additional intraplantar injections of rhNGF (5 x 4 microg) during this time period were able to raise CGRP mRNA expression again.	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
10605941-7	1999	The percentage of the CGRP-expressing neurons in capsaicinized and in capsaicin + NGF-treated animals stayed unaltered.	Capsaicin	49-58	calcitonin-related polypeptide alpha	Rattus norvegicus	22-26
11498940-3	1999	All of 30 PGL neurons recorded responded to intracarotid injection of capsaicin with an increase in spontaneous discharge rate from 12.6 +/- 0.7 to 20.9 +/- 1.1 spikes/s (P < 0.001); (2) In 10 units, the excitatory response of PGL neurons to intracarotid injection of capsaicin was significantly inhibited by pretreatment with the vanilloid receptor (capsaicin receptor) antagonist ruthenium red (200 mmol, 0.1 ml).	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	354-372
10547475-1	1999	In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis.	Capsaicin	68-77	tachykinin precursor 1	Homo sapiens	149-160
10619644-6	1999	BDNF gene expression in these neurons was down-regulated after application of capsaicin to the sciatic nerve.	Capsaicin	78-87	brain-derived neurotrophic factor	Rattus norvegicus	0-4
10674924-4	1999	Administration of 400 microg capsaicin significantly increased the slope of gastric emptying curve (from 0.1 +/- 0.01 to 0.139 +/- 0.014 U x min(-1), P < 0.05) and significantly decreased the time belonging to the maximum value of emptying curve (from 150 +/- 18 to 75 +/- 12 min, P < 0.05) and the time belonging to the 50% of the area under the curve (from 112 +/- 15 to 99 +/- 14 min, P < 0.05).	Capsaicin	29-38	CD59 molecule (CD59 blood group)	Homo sapiens	141-147
10547475-1	1999	In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis.	Capsaicin	68-77	calcitonin related polypeptide alpha	Homo sapiens	162-193
10547475-1	1999	In this in vivo prospective, controlled study, we have examined the capsaicin-induced levels and secretion patterns of the colocalized neuropeptides substance P, calcitonin gene-related peptide (CGRP), and neurokinin A in nasal secretions of subjects with nasal polyps, and we compared these with secretion patterns from healthy subjects and from subjects with allergic rhinitis.	Capsaicin	68-77	tachykinin precursor 1	Homo sapiens	206-218
10547475-9	1999	Atopic subjects had higher neurokinin A levels with an immediate and sustained response to capsaicin.	Capsaicin	91-100	tachykinin precursor 1	Homo sapiens	27-39
10548414-6	1999	We conclude that NGF acutely conditions the response to capsaicin via direct action on DRG cells.	Capsaicin	56-65	nerve growth factor	Rattus norvegicus	17-20
10543438-0	1999	Involvement of endogenous tachykinins and CGRP in the motor responses produced by capsaicin in the guinea-pig common bile duct.	Capsaicin	82-91	calcitonin related polypeptide alpha	Homo sapiens	42-46
10520965-0	1999	Capsaicin induces cystatin S-like substances in submandibular saliva of the rat.	Capsaicin	0-9	cystatin S	Rattus norvegicus	18-28
10520965-11	1999	The results suggest that dietary capsaicin induces cystatin S-like substances in submandibular saliva by stimulating the reflex arc involving the glossopharyngeal nerve.	Capsaicin	33-42	cystatin S	Rattus norvegicus	51-61
10511462-0	1999	Increased expression of GAP-43 in small sensory neurons after stimulation by NGF indicative of neuroregeneration in capsaicin-treated rats.	Capsaicin	116-125	growth associated protein 43	Rattus norvegicus	24-30
10511462-1	1999	Intraplantar injections of human recombinant nerve growth factor (rhNGF-beta) into the hind paw of capsaicin-treated adult rats are known to lead to a recovery of depleted peptide transmitter substances, to the immunohistochemical reappearance of peptidergic innervation in the skin and in the dorsal horn of the spinal cord, as well as to a recovery of the function of capsaicin-lesioned neurons.	Capsaicin	99-108	nerve growth factor	Homo sapiens	45-64
10511462-1	1999	Intraplantar injections of human recombinant nerve growth factor (rhNGF-beta) into the hind paw of capsaicin-treated adult rats are known to lead to a recovery of depleted peptide transmitter substances, to the immunohistochemical reappearance of peptidergic innervation in the skin and in the dorsal horn of the spinal cord, as well as to a recovery of the function of capsaicin-lesioned neurons.	Capsaicin	370-379	nerve growth factor	Homo sapiens	45-64
10511462-3	1999	In situ hybridization histochemistry (ISH) revealed that at day 8 after the capsaicin treatment GAP-43 expression was significantly increased in small DRG cells as compared to control animals, and treatment with NGF in capsaicinized rats lead to an even more pronounced increase of GAP-43 expression in the small-sized cell population.	Capsaicin	76-85	growth associated protein 43	Rattus norvegicus	96-102
10511462-3	1999	In situ hybridization histochemistry (ISH) revealed that at day 8 after the capsaicin treatment GAP-43 expression was significantly increased in small DRG cells as compared to control animals, and treatment with NGF in capsaicinized rats lead to an even more pronounced increase of GAP-43 expression in the small-sized cell population.	Capsaicin	76-85	growth associated protein 43	Rattus norvegicus	282-288
10511462-4	1999	Intraepidermal labelling of GAP-43 peptide was observed in the skin of control animals, but was markedly reduced in the animals that were treated with capsaicin alone.	Capsaicin	151-160	growth associated protein 43	Rattus norvegicus	28-34
10511462-5	1999	However, intraepidermal GAP-43 immunoreactive (GAP-43-IR) fibres nearly fully recovered in the capsaicin + NGF-treated group.	Capsaicin	95-104	growth associated protein 43	Rattus norvegicus	24-30
10511462-5	1999	However, intraepidermal GAP-43 immunoreactive (GAP-43-IR) fibres nearly fully recovered in the capsaicin + NGF-treated group.	Capsaicin	95-104	growth associated protein 43	Rattus norvegicus	47-53
10513557-0	1999	Role of calcitonin gene-related peptide and capsaicin-sensitive afferents in central thyrotropin-releasing hormone-induced hepatic hyperemia.	Capsaicin	44-53	thyrotropin releasing hormone	Homo sapiens	85-114
10513557-2	1999	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the stimulatory effect of hepatic blood flow induced by intracisternal injection of TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 100 ng), assessed by the hydrogen gas clearance method.	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	71-75
10513557-2	1999	Both systemic capsaicin pretreatment and intravenous administration of CGRP receptor antagonist, human CGRP-(8-37), completely abolished the stimulatory effect of hepatic blood flow induced by intracisternal injection of TRH analog (RX-77368; p-Glu-His-(3,3"-dimethyl)-Pro-NH2, 100 ng), assessed by the hydrogen gas clearance method.	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	103-107
10462546-5	1999	The typical vanilloid agonists olvanil and capsaicin inhibited [(3)H]RTX binding to HEK293/VR1 cells with K(i) values of 0.4 and 4.0 microM, respectively.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	91-94
10462546-5	1999	The typical vanilloid agonists olvanil and capsaicin inhibited [(3)H]RTX binding to HEK293/VR1 cells with K(i) values of 0.4 and 4.0 microM, respectively.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	91-94
10462546-9	1999	RTX and capsaicin induced calcium mobilization in HEK293/VR1 cells with EC(50) values of 4.1 and 82 nM, respectively.	Capsaicin	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	57-60
10548414-5	1999	Ten minute pretreatment with NGF increased the initial response to capsaicin.	Capsaicin	67-76	nerve growth factor	Rattus norvegicus	29-32
10555540-7	1999	Also, capsaicin treatment substantially reduced the calretinin-positive fibers in the uterus and pelvic ganglia, thus indicating the sensory nature of these fibers.	Capsaicin	6-15	calbindin 2	Rattus norvegicus	52-62
10523362-8	1999	Our data are consistent with the suggestion that reductions of both basal coronary flow and cardiomyocyte size seen in hearts from capsaicin-pretreated rats may be consequences of CGRP depletion.	Capsaicin	131-140	calcitonin-related polypeptide alpha	Rattus norvegicus	180-184
10523362-9	1999	The cardiomyocyte size reduction produced by capsaicin treatment may be related to a modulatory role of CGRP as a growth factor.	Capsaicin	45-54	calcitonin-related polypeptide alpha	Rattus norvegicus	104-108
10546991-10	1999	capsaicin resulted in a complete block of the reduced threshold produced by nociceptin.	Capsaicin	0-9	prepronociceptin	Homo sapiens	76-86
10543438-6	1999	Human calcitonin gene-related peptide (h-CGRP; 0.1 microM) mimicked the effect of capsaicin on resting preparations (contractile response =28% of KCl 80 mM).	Capsaicin	82-91	calcitonin related polypeptide alpha	Homo sapiens	41-45
10543438-9	1999	h-CGRP (8-37) (1.5 microM) almost completely reversed the relaxations produced by both capsaicin and h-CGRP.	Capsaicin	87-96	calcitonin related polypeptide alpha	Homo sapiens	2-6
10543438-14	1999	In vivo pretreatment with capsaicin (50 mg/kg; 6-7 days before) decreased the number of CGRP-IR nerves, whereas the TK-IR neural network was apparently unchanged.	Capsaicin	26-35	calcitonin related polypeptide alpha	Homo sapiens	88-92
10543438-15	1999	In conclusion, our data provide functional evidence for the presence of capsaicin-sensitive primary afferent nerve endings in the guinea-pig terminal biliary tract, whose stimulation by capsaicin or EFS produces the release of tachykinins and CGRP.	Capsaicin	72-81	calcitonin related polypeptide alpha	Homo sapiens	243-247
10543438-15	1999	In conclusion, our data provide functional evidence for the presence of capsaicin-sensitive primary afferent nerve endings in the guinea-pig terminal biliary tract, whose stimulation by capsaicin or EFS produces the release of tachykinins and CGRP.	Capsaicin	186-195	calcitonin related polypeptide alpha	Homo sapiens	243-247
10543438-17	1999	Tachykinins, probably released in small amounts by capsaicin, act by activating receptors of the NK1, NK2 and NK3 type, most probably located on intrinsic cholinergic neurons, which in turn release ACh to produce the final excitatory motor response.	Capsaicin	51-60	tachykinin receptor 1	Homo sapiens	97-100
10543438-17	1999	Tachykinins, probably released in small amounts by capsaicin, act by activating receptors of the NK1, NK2 and NK3 type, most probably located on intrinsic cholinergic neurons, which in turn release ACh to produce the final excitatory motor response.	Capsaicin	51-60	tachykinin receptor 2	Homo sapiens	102-105
10543438-17	1999	Tachykinins, probably released in small amounts by capsaicin, act by activating receptors of the NK1, NK2 and NK3 type, most probably located on intrinsic cholinergic neurons, which in turn release ACh to produce the final excitatory motor response.	Capsaicin	51-60	NK3 homeobox 1	Homo sapiens	110-113
10543438-18	1999	The contractile response to capsaicin obtained in the presence of the three tachykinin receptor antagonists could be due to the co-released CGRP and/or to other unknown neurotransmitters.	Capsaicin	28-37	calcitonin related polypeptide alpha	Homo sapiens	140-144
11245085-4	1999	Investigations using capsaicin suggest that secretoneurin functions as an excitatory transmitter.	Capsaicin	21-30	secretogranin II	Homo sapiens	44-57
10444445-6	1999	Excitation of pancreatic sensory nerves using capsaicin (in the absence of SP) inhibited both amylase and pancreatic juice flow via activation of the NK1 receptor.	Capsaicin	46-55	tachykinin receptor 1	Rattus norvegicus	150-162
10496326-2	1999	Heat and protons as well as capsaicin activate VR1 to induce the influx of cations, particularly Ca2+ and Na+ ions.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-50
10491977-8	1999	Both NGF and GDNF have also been shown to regulate the sensitivity of nociceptors to heat and capsaicin in the adult.	Capsaicin	94-103	nerve growth factor	Homo sapiens	5-8
10491977-8	1999	Both NGF and GDNF have also been shown to regulate the sensitivity of nociceptors to heat and capsaicin in the adult.	Capsaicin	94-103	glial cell derived neurotrophic factor	Homo sapiens	13-17
10489905-1	1999	The effects of infusion of the two tachykinins, substance P (SP) and neurokinin A (NKA), and of capsaicin on the release of glucagon-like peptide-1 (GLP-1), somatostatin, and vasoactive intestinal polypeptide (VIP) were studied in isolated, vascularly perfused ileal segments.	Capsaicin	96-105	glucagon	Homo sapiens	124-147
10494891-0	1999	Nociceptin protects capsaicin-sensitive afferent fibers in the rat urinary bladder from desensitization.	Capsaicin	20-29	prepronociceptin	Rattus norvegicus	0-10
10494891-4	1999	administration of the novel neuropeptide nociceptin (100 nmol/kg) produced a long-lasting protection from capsaicin desensitization of afferent nerves which mediate the chemoceptive micturition reflex.	Capsaicin	106-115	prepronociceptin	Rattus norvegicus	41-51
10494891-5	1999	In fact a chemoceptive micturition reflex could be repeatedly evoked by topical capsaicin in nociceptin-pretreated rats.	Capsaicin	80-89	prepronociceptin	Rattus norvegicus	93-103
10494891-7	1999	These results suggest that the afferent and "efferent" function of capsaicin-sensitive primary afferent neurons (CSPANs) in the rat bladder are differentiated by nociceptin.	Capsaicin	67-76	prepronociceptin	Rattus norvegicus	162-172
10489905-7	1999	Simultaneous addition of receptor antagonists to all three tachykinin receptors (CP96345, SR48968, and SR142801, all at 10(-6) M) significantly inhibited the effect of capsaicin on VIP release, whereas the release of GLP-1 and somatostatin was unaffected.	Capsaicin	168-177	vasoactive intestinal peptide	Homo sapiens	181-184
10489905-7	1999	Simultaneous addition of receptor antagonists to all three tachykinin receptors (CP96345, SR48968, and SR142801, all at 10(-6) M) significantly inhibited the effect of capsaicin on VIP release, whereas the release of GLP-1 and somatostatin was unaffected.	Capsaicin	168-177	glucagon	Homo sapiens	217-222
10393882-10	1999	NGF acutely conditions the response to capsaicin, suggesting that NGF may be important in sensitizing the response of sensory neurons to heat (a process that is thought to operate via the capsaicin receptor VR1).	Capsaicin	39-48	vault RNA 1-1	Homo sapiens	207-210
10489905-6	1999	Capsaicin infusions (10(-5) M) significantly stimulated both GLP-1, somatostatin, and VIP release to 111.1+/-4.5% (N = 9), 138.0+/-15.8% (N = 9) and 208.3+/-63.8% (N = 8) of basal release, respectively.	Capsaicin	0-9	glucagon	Homo sapiens	61-66
10489905-6	1999	Capsaicin infusions (10(-5) M) significantly stimulated both GLP-1, somatostatin, and VIP release to 111.1+/-4.5% (N = 9), 138.0+/-15.8% (N = 9) and 208.3+/-63.8% (N = 8) of basal release, respectively.	Capsaicin	0-9	vasoactive intestinal peptide	Homo sapiens	86-89
10380072-11	1999	Similarly, murine leukemia inhibitory factor produced a greater percentage of neurons (57%) with sensitivity to capsaicin (sensory phenotype) than human leukemia inhibitory factor (3%).	Capsaicin	112-121	leukemia inhibitory factor	Mus musculus	18-44
10400956-3	1999	Subtypes mGluR1 and mGluR5 are classified as group I mGluRs and share the ability to stimulate phosphoinositide hydrolysis and activate protein kinase C. The present study examined the role of group I mGluRs in nociceptive processing and capsaicin-induced central sensitization of primate spinothalamic tract (STT) cells in vivo.	Capsaicin	238-247	glutamate receptor, ionotropic, kainate 1	Mus musculus	20-26
10400956-14	1999	The enhancement of the responses by capsaicin resembled the potentiation by the group I mGluR agonist S-DHPG (BRUSH > PRESS > PINCH).	Capsaicin	36-45	LIM zinc finger domain containing 1	Homo sapiens	132-137
10400956-18	1999	These data suggest that the mGluR1 subtype is activated endogenously during brief high-intensity cutaneous stimuli (PRESS, PINCH) and is critically involved in capsaicin-induced central sensitization.	Capsaicin	160-169	glutamate metabotropic receptor 1	Homo sapiens	28-34
10336535-7	1999	After capsaicin treatment, the slopes of the Schild plots were not different from one, and a higher affinity of h-CGRP(8-37) in blocking relaxation was obtained (log10 of the antagonist equilibrium dissociation constant = -6.01).	Capsaicin	6-15	calcitonin related polypeptide alpha	Homo sapiens	114-118
10366753-3	1999	Kyo-responses were also abolished by the local pretreatment with capsaicin to deplete substance P from nociceptor endings, and in tachykinin 1 gene K/O mice.	Capsaicin	65-74	tachykinin 1	Mus musculus	86-97
10458643-12	1999	Capsaicin denervation attenuated CCK-induced ulcer healing, and the accompanying rise in the GBF at the ulcer margin and decreased plasma gastrin and luminal release of somatostatin when compared to those in rats with intact sensory nerves.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	33-36
10458643-12	1999	Capsaicin denervation attenuated CCK-induced ulcer healing, and the accompanying rise in the GBF at the ulcer margin and decreased plasma gastrin and luminal release of somatostatin when compared to those in rats with intact sensory nerves.	Capsaicin	0-9	gastrin	Rattus norvegicus	138-145
10458643-12	1999	Capsaicin denervation attenuated CCK-induced ulcer healing, and the accompanying rise in the GBF at the ulcer margin and decreased plasma gastrin and luminal release of somatostatin when compared to those in rats with intact sensory nerves.	Capsaicin	0-9	somatostatin	Rattus norvegicus	169-181
10360863-0	1999	Neurokinin-1 receptors are involved in behavioral responses to high-intensity heat stimuli and capsaicin-induced hyperalgesia in mice.	Capsaicin	95-104	tachykinin 1	Mus musculus	0-12
10360863-10	1999	CONCLUSION: NK-1 receptors contribute to the withdrawal responses to high-intensity heat stimuli and to capsaicin-induced mechanical and heat hyperalgesia.	Capsaicin	104-113	tachykinin 1	Mus musculus	12-16
10401552-0	1999	Non-NMDA glutamate receptors modulate capsaicin induced c-fos expression within trigeminal nucleus caudalis.	Capsaicin	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-61
10401552-5	1999	The number of positive c-fos cells increased by 17 fold after intracisternal capsaicin (5 nmol) administration.	Capsaicin	77-86	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	23-28
10363926-3	1999	Fos expression was increased in the ARC after capsaicin injection compared with vehicle-treated rats.	Capsaicin	46-55	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
10431759-8	1999	Pretreatment with capsaicin (50 mg/kg s.c.), which specifically depletes sensory nerve transmitter content, abolished both the cardioprotection and the increased release of CGRP-LI.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	173-177
10408253-15	1999	The present results suggest that: (1) both CCK1 and CCK2 receptors mediate the peptic secretory responses induced by CCK-like peptides; (2) the excitatory inputs of CCK-8S and gastrin-I to chief cells are not driven through acid-dependent mechanisms or capsaicin-sensitive afferent sensory nerves; and (3) under in vivo conditions, the stimulant actions of CCK-like peptides on pepsinogen secretion are mediated, at least in part, by an increase in NO generation.	Capsaicin	253-262	C-C motif chemokine ligand 28	Homo sapiens	43-47
10408253-15	1999	The present results suggest that: (1) both CCK1 and CCK2 receptors mediate the peptic secretory responses induced by CCK-like peptides; (2) the excitatory inputs of CCK-8S and gastrin-I to chief cells are not driven through acid-dependent mechanisms or capsaicin-sensitive afferent sensory nerves; and (3) under in vivo conditions, the stimulant actions of CCK-like peptides on pepsinogen secretion are mediated, at least in part, by an increase in NO generation.	Capsaicin	253-262	cholecystokinin	Homo sapiens	43-46
10408253-15	1999	The present results suggest that: (1) both CCK1 and CCK2 receptors mediate the peptic secretory responses induced by CCK-like peptides; (2) the excitatory inputs of CCK-8S and gastrin-I to chief cells are not driven through acid-dependent mechanisms or capsaicin-sensitive afferent sensory nerves; and (3) under in vivo conditions, the stimulant actions of CCK-like peptides on pepsinogen secretion are mediated, at least in part, by an increase in NO generation.	Capsaicin	253-262	cholecystokinin	Homo sapiens	52-55
10408253-15	1999	The present results suggest that: (1) both CCK1 and CCK2 receptors mediate the peptic secretory responses induced by CCK-like peptides; (2) the excitatory inputs of CCK-8S and gastrin-I to chief cells are not driven through acid-dependent mechanisms or capsaicin-sensitive afferent sensory nerves; and (3) under in vivo conditions, the stimulant actions of CCK-like peptides on pepsinogen secretion are mediated, at least in part, by an increase in NO generation.	Capsaicin	253-262	gastrin	Rattus norvegicus	176-183
10408253-15	1999	The present results suggest that: (1) both CCK1 and CCK2 receptors mediate the peptic secretory responses induced by CCK-like peptides; (2) the excitatory inputs of CCK-8S and gastrin-I to chief cells are not driven through acid-dependent mechanisms or capsaicin-sensitive afferent sensory nerves; and (3) under in vivo conditions, the stimulant actions of CCK-like peptides on pepsinogen secretion are mediated, at least in part, by an increase in NO generation.	Capsaicin	253-262	cholecystokinin	Homo sapiens	52-55
10395411-11	1999	Capsaicin locally applied in duodenal mucosa significantly decreased CCK-8 response, whereas mucosal exposure to lidocaine completely blocked CCK-8 response.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	69-72
10384913-6	1999	However, a correlation was observed between levels of prostaglandin E2 and interleukin-1alpha in capsaicin pre-treated blister fluids (r=0.58, p<0.01, n=19).	Capsaicin	97-106	interleukin 1 alpha	Homo sapiens	75-93
10328967-5	1999	Immunohistochemical analysis revealed that capsaicin treatment depleted substance P from the lacrimal gland.	Capsaicin	43-52	tachykinin 1	Mus musculus	72-83
10409843-8	1999	These findings suggest that some of the FRAP-positive terminals are capsaicin-sensitive, thereby indicating their nociceptive primary afferent.	Capsaicin	68-77	acid phosphatase, prostate	Mus musculus	40-44
10363926-4	1999	Pretreatment with the NO synthase (NOS) inhibitor, N(omega)-nitro-L-arginine methyl ester (L-NAME) attenuated the effect of capsaicin on Fos expression and NADPH-d reactivity in the ARC-ME in comparison with rats injected with D-NAME, the inactive stereoisomer of L-NAME.	Capsaicin	124-133	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	137-140
10087087-9	1999	After capsaicin treatment, c-fos and JunB induction by balloon passage was inhibited in the IMG, but there was enhanced c-fos expression in the myenteric plexus.	Capsaicin	6-15	transcription factor jun-B	Cavia porcellus	37-41
10323258-6	1999	The antinociceptive effects of nociceptin/orphanin FQ in diabetic, but not in non-diabetic mice, were abolished when mice were pretreated with capsaicin i.t.	Capsaicin	143-152	prepronociceptin	Mus musculus	42-53
10087087-10	1999	c-fos and JunB induction by balloon stimulation was also mimicked by acute activation of capsaicin-sensitive nerves.	Capsaicin	89-98	transcription factor jun-B	Cavia porcellus	10-14
10188948-8	1999	A concomitant tachyphylaxis to substance P (natural neurokinin-1 receptor stimulant) and the neurokinin-3 receptor agonist senktide (5 and 1 microM, respectively) also reduced the contractile effect of capsaicin.	Capsaicin	202-211	substance-P receptor	Cavia porcellus	52-73
10090847-10	1999	Finally, capsaicin or 6-OH-DA treatment increased the number of Fos-ir nuclei in enteric ganglia.	Capsaicin	9-18	proto-oncogene c-Fos	Cavia porcellus	64-67
10188948-8	1999	A concomitant tachyphylaxis to substance P (natural neurokinin-1 receptor stimulant) and the neurokinin-3 receptor agonist senktide (5 and 1 microM, respectively) also reduced the contractile effect of capsaicin.	Capsaicin	202-211	neuromedin-K receptor	Cavia porcellus	93-114
10353438-10	1999	It provides functional evidence that activation of peripheral cannabinoid CB1 receptors can attenuate capsaicin-induced thermal nociception in non-human primates and suggests a new approach for cannabinoids in pain management.	Capsaicin	102-111	cannabinoid receptor 1	Macaca mulatta	74-77
10225363-4	1999	c-fos expression was induced in urethane-anaesthetized rats by intracisternal capsaicin administration.	Capsaicin	78-87	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-5
10360450-1	1999	The aim of this study was to determine whether intravesical treatment with capsaicin could block detrusor hyper-reflexia (DH) and alter the substance P content, nerve fibres and mucosa of the bladder.	Capsaicin	75-84	tachykinin precursor 1	Homo sapiens	140-151
10225363-5	1999	Sumatriptan and LY 344864 decreased the number of capsaicin-induced c-fos-like immunoreactive cells within trigeminal nucleus caudalis (ID50 = 0.04 and 0.6 mg kg(-1)).	Capsaicin	50-59	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	68-73
10206178-7	1999	Pretreatment with capsaicin (50 mg/kg, s.c.), which specifically depletes the transmitter content of sensory nerves, also abolished the protective effects of nitroglycerin and markedly reduced the release of CGRP from the heart during nitroglycerin perfusion.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	208-212
10077663-5	1999	Sensitization of the foot withdrawal response after application of capsaicin (C fibers) or dimethyl sulfoxide (Adelta fibers) observed in control animals was reduced or eliminated in animals infected with the proenkephalin-encoding virus for at least 7 weeks postinfection.	Capsaicin	67-76	proenkephalin	Homo sapiens	209-222
10202384-9	1999	Capsaicin at 10-6 mol L-1 and potassium at 70 mmol L-1 induced a profound increase in airway tone (50 +/- 9 and 42 +/- 8 cmH2O mL-1 min respectively; P < 0.01) and elevation of both CGRP (6.4 +/- 1.9 and 3.9 +/- 1.1 fmol mL-1 g respectively; P < 0.05) and NKA (3.3 +/- 1.0 and 1.0 +/- 0.2 fmol mL-1 respectively; P < 0.05).	Capsaicin	0-9	L1 cell adhesion molecule	Mus musculus	22-25
10203234-2	1999	Kinin B1 receptor stimulation induces excitatory motor responses in the urinary bladder and, in this preparation, the effect of many excitatory transmitters involves the stimulation of capsaicin-sensitive afferent nerves.	Capsaicin	185-194	bradykinin receptor B1	Rattus norvegicus	0-17
10203234-3	1999	In this study we have investigated the effect of capsaicin pretreatment on the bladder contractions induced by [Sar0, D-Phe8, des-Arg9]bradykinin (SDABK), a kinin B1 receptor agonist, by inducing the expression of B1 receptors via the intravesical administration of a bacterial endotoxin (LPS, 1 mg/ml) in urethane-anaesthetized rats.	Capsaicin	49-58	bradykinin receptor B1	Rattus norvegicus	157-174
10103088-1	1999	The vanilloid receptor (VR1) protein functions both as a receptor for capsaicin and a transducer of noxious thermal stimuli.	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-27
10361881-7	1999	Recently, the receptor for capsaicin (the vanilloid receptor 1: VR1) has been cloned, identified and characterized.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-67
10233257-6	1999	Capsaicin treatment and/or sciatic nerve sectioning reduced the density of CGRP-immunoreactive nerve fibres by 70% and that of PGP 9.5-immunoreactive fibres by 50%.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	75-79
10233257-6	1999	Capsaicin treatment and/or sciatic nerve sectioning reduced the density of CGRP-immunoreactive nerve fibres by 70% and that of PGP 9.5-immunoreactive fibres by 50%.	Capsaicin	0-9	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	127-134
10233257-7	1999	The capsaicin-induced reduction in PGP 9.5-immunoreactive nerve fibre density is attributable to partial destruction of peripheral nerve fibres.	Capsaicin	4-13	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	35-42
10233257-8	1999	CGRP-immunoreactive and PGP 9.5-immunoreactive nerve fibre density was restored both in capsaicin-treated and denervated groups, reaching a maximum, corresponding to the original level, by days 4-10.	Capsaicin	88-97	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
10233257-8	1999	CGRP-immunoreactive and PGP 9.5-immunoreactive nerve fibre density was restored both in capsaicin-treated and denervated groups, reaching a maximum, corresponding to the original level, by days 4-10.	Capsaicin	88-97	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	24-31
10103088-8	1999	Surprisingly, VR1-ir did not coexist substantially in nerve fibres and terminals that contain substance P and calcitonin gene-related peptide, suggesting complex mechanisms for the release of these neuropeptides in response to capsaicin application.	Capsaicin	227-236	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-17
10202384-9	1999	Capsaicin at 10-6 mol L-1 and potassium at 70 mmol L-1 induced a profound increase in airway tone (50 +/- 9 and 42 +/- 8 cmH2O mL-1 min respectively; P < 0.01) and elevation of both CGRP (6.4 +/- 1.9 and 3.9 +/- 1.1 fmol mL-1 g respectively; P < 0.05) and NKA (3.3 +/- 1.0 and 1.0 +/- 0.2 fmol mL-1 respectively; P < 0.05).	Capsaicin	0-9	L1 cell adhesion molecule	Mus musculus	127-131
10202384-9	1999	Capsaicin at 10-6 mol L-1 and potassium at 70 mmol L-1 induced a profound increase in airway tone (50 +/- 9 and 42 +/- 8 cmH2O mL-1 min respectively; P < 0.01) and elevation of both CGRP (6.4 +/- 1.9 and 3.9 +/- 1.1 fmol mL-1 g respectively; P < 0.05) and NKA (3.3 +/- 1.0 and 1.0 +/- 0.2 fmol mL-1 respectively; P < 0.05).	Capsaicin	0-9	L1 cell adhesion molecule	Mus musculus	224-228
10202384-9	1999	Capsaicin at 10-6 mol L-1 and potassium at 70 mmol L-1 induced a profound increase in airway tone (50 +/- 9 and 42 +/- 8 cmH2O mL-1 min respectively; P < 0.01) and elevation of both CGRP (6.4 +/- 1.9 and 3.9 +/- 1.1 fmol mL-1 g respectively; P < 0.05) and NKA (3.3 +/- 1.0 and 1.0 +/- 0.2 fmol mL-1 respectively; P < 0.05).	Capsaicin	0-9	L1 cell adhesion molecule	Mus musculus	224-228
10050022-2	1999	Capsaicin activation of the pulmonary C fibre vanilloid receptor (VR1) evokes the pulmonary chemoreflex and reflex bronchoconstriction.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Canis lupus familiaris	66-69
10024368-2	1999	The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	20-48
10024368-2	1999	The recently cloned vanilloid receptor subtype 1 (VR1) is activated by capsaicin and noxious heat.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	50-53
10085334-7	1999	Intradermal injection of capsaicin increased dramatically the content of NO metabolites, NO-2/NO-3, within the dorsal horn.	Capsaicin	25-34	NBL1, DAN family BMP antagonist	Homo sapiens	89-98
10100927-5	1999	However, after pretreatment with capsaicin (50 mg/kg, s.c.) to deplete CGRP in cardiac sensory nerves, the plasma concentration of CGRP was no longer increased and the cardioprotection afforded by heat stress was abolished.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	71-75
10078998-2	1999	A frequency-dependent vasoconstriction induced by periarterial nerve stimulation (1-6 Hz) of the bed was significantly potentiated by perfusion of 1 microM CGRP-(8-37) (CGRP receptor antagonist) or to a similar extent after treatment with 500 nM capsaicin.	Capsaicin	246-255	calcitonin-related polypeptide alpha	Rattus norvegicus	156-160
10078998-3	1999	In the preparations treated with capsaicin, CGRP-(8-37) caused a small potentiation of periarterial nerve stimulation-induced vasoconstriction.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
10078998-4	1999	Exogenous CGRP (0.1-1 nM) concentration-dependently attenuated the augmented vasoconstriction in response to periarterial nerve stimulation after treatment with capsaicin.	Capsaicin	161-170	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
10100927-5	1999	However, after pretreatment with capsaicin (50 mg/kg, s.c.) to deplete CGRP in cardiac sensory nerves, the plasma concentration of CGRP was no longer increased and the cardioprotection afforded by heat stress was abolished.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	131-135
9973426-4	1999	A significant increase in VCAM-1 immunostaining of microvascular endothelium was observed in vivo following capsaicin application to human skin.	Capsaicin	108-117	vascular cell adhesion molecule 1	Homo sapiens	26-32
9972801-8	1999	Capsaicin treatment did not affect nerve fiber density in the tracheal smooth muscle but produced a significant reduction in the density of epithelial VIP- and SP-IR nerve fibers after 1 day.	Capsaicin	0-9	VIP peptides	Mustela putorius furo	151-154
10193773-7	1999	This difference was not gender-specific and responses to capsaicin were abolished by pretreatment with a selective NK1 receptor antagonist SR 140333 (360 nmol kg(-1)).	Capsaicin	57-66	tachykinin receptor 1	Rattus norvegicus	115-127
9918586-1	1999	Capsaicin depolarizes primary afferent C-fibers releasing substance P (SP) whose N-terminal metabolites appear to play a role in the development of antinociception.	Capsaicin	0-9	tachykinin 1	Mus musculus	58-69
9918586-1	1999	Capsaicin depolarizes primary afferent C-fibers releasing substance P (SP) whose N-terminal metabolites appear to play a role in the development of antinociception.	Capsaicin	0-9	tachykinin 1	Mus musculus	71-73
9918586-14	1999	injection of zinc (90 min) is greatly attenuated by 24 h. Thus, zinc appears to be necessary, but may not be sufficient, for the long-term antinociceptive effect of capsaicin, acting downstream from the action of substance P N-terminal metabolites.	Capsaicin	165-174	tachykinin 1	Mus musculus	213-224
10202860-0	1999	Central injections of capsaicin cause antidiuresis mediated through neurokinin-1 receptors in rat hypothalamus and vasopressin release.	Capsaicin	22-31	arginine vasopressin	Rattus norvegicus	115-126
10068156-13	1999	In this area of dynamic allodynia, electrical stimulation at stimulus intensities that were not painful before capsaicin injection (A beta-stimulation) was now able to elicit a burning painful sensation (NAS 1.5-3).	Capsaicin	111-120	amyloid beta precursor protein	Homo sapiens	132-138
10202860-2	1999	The capsaicin (500 nmol)-induced antidiuresis was inhibited by pretreatment with CP96345 (30 nmol, a neurokinin-1-receptor antagonist), but not by that with phenoxybenzamine (20 nmol, an alpha-adrenoceptor antagonist), timolol (100 nmol, a beta-adrenoceptor antagonist) or atropine (300 nmol, a muscarinic antagonist) into the hypothalamic supraoptic nucleus (SON).	Capsaicin	4-13	tachykinin receptor 1	Rattus norvegicus	101-122
10202860-5	1999	These findings suggested that capsaicin stimulated substance P release in the SON and caused the antidiuresis as a result of the increased release of vasopressin into the circulation from the neurohypophysis mediated through neurokinin-1 receptors in the SON.	Capsaicin	30-39	arginine vasopressin	Rattus norvegicus	150-161
9932722-3	1999	We have investigated the neuromodulatory effects of endothelin-1 on capsaicin-induced release of neurotransmitters from rat vas deferens.	Capsaicin	68-77	endothelin 1	Rattus norvegicus	52-64
9974123-3	1999	The present study was aimed at investigating the neurochemical, immunohistochemical and functional recovery of peripheral and central terminals of capsaicin-lesioned afferents following administration of recombinant human NGF-beta (rhNGF-beta).	Capsaicin	147-156	nerve growth factor	Homo sapiens	222-230
9974123-9	1999	In the paw skin, the CGRP-immunoreactive (CGRP-IR) nerve endings were restricted to a fragmentary subepidermal plexus after the capsaicin treatment, whereas the subsequent NGF treatment caused a bilateral recovery of the subepidermal plexus and an intact reinnervation of the epidermis and blood vessels with free nerve terminals.	Capsaicin	128-137	calcitonin-related polypeptide alpha	Rattus norvegicus	21-25
9974123-9	1999	In the paw skin, the CGRP-immunoreactive (CGRP-IR) nerve endings were restricted to a fragmentary subepidermal plexus after the capsaicin treatment, whereas the subsequent NGF treatment caused a bilateral recovery of the subepidermal plexus and an intact reinnervation of the epidermis and blood vessels with free nerve terminals.	Capsaicin	128-137	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
9974123-10	1999	The capsaicin-induced fragmentation of the CGRP terminal plexus in laminae I and II of the lumbar spinal dorsal horn was also markedly repaired on both sides by the intraplantar NGF injections.	Capsaicin	4-13	calcitonin-related polypeptide alpha	Rattus norvegicus	43-47
9974123-11	1999	The NGF treatment caused the CGRP nerve terminals in the spinal cord to regain their ability of releasing transmitter upon capsaicin stimulation as shown in tissue slice superfusion experiments.	Capsaicin	123-132	calcitonin-related polypeptide alpha	Rattus norvegicus	29-33
9932722-0	1999	Endothelin-1 affects capsaicin-evoked release of neuropeptides from rat vas deferens.	Capsaicin	21-30	endothelin 1	Rattus norvegicus	0-12
10457322-1	1999	Ablation of a-calcitonin gene-related polypeptide (CGRP) containing neurons with the afferent neurotoxin capsaicin improves postoperative foregut transit in a rodent model.	Capsaicin	105-114	calcitonin-related polypeptide alpha	Rattus norvegicus	12-49
9932722-1	1999	Capsaicin-sensitive neurones release a number of neuropeptides, such as substance P, neurokinin A, somatostatin and calcitonin gene-related peptide (CGRP), which exert a number of effects on smooth muscle tissues.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	72-83
9932722-1	1999	Capsaicin-sensitive neurones release a number of neuropeptides, such as substance P, neurokinin A, somatostatin and calcitonin gene-related peptide (CGRP), which exert a number of effects on smooth muscle tissues.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	85-97
9932722-1	1999	Capsaicin-sensitive neurones release a number of neuropeptides, such as substance P, neurokinin A, somatostatin and calcitonin gene-related peptide (CGRP), which exert a number of effects on smooth muscle tissues.	Capsaicin	0-9	somatostatin	Homo sapiens	99-111
9932722-1	1999	Capsaicin-sensitive neurones release a number of neuropeptides, such as substance P, neurokinin A, somatostatin and calcitonin gene-related peptide (CGRP), which exert a number of effects on smooth muscle tissues.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	116-147
9932722-1	1999	Capsaicin-sensitive neurones release a number of neuropeptides, such as substance P, neurokinin A, somatostatin and calcitonin gene-related peptide (CGRP), which exert a number of effects on smooth muscle tissues.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	149-153
9932722-2	1999	Endothelin-1 was thought to potentiate the capsaicin-evoked release of neuropeptides from sensory neurones of the rat.	Capsaicin	43-52	endothelin 1	Rattus norvegicus	0-12
9932722-6	1999	Endothelin-1 concentration dependently evoked an increase in basal tone of the musculature and potentiated the amplitude of the electrically stimulated responses, blocking inhibitory effects of capsaicin but not of human alphaCGRP.	Capsaicin	194-203	endothelin 1	Homo sapiens	0-12
9932722-9	1999	The endothelin-1-induced block of the capsaicin effect was resistant to tetrodotoxin (1 microM) and 30-min pre-treatment with MEN 10.627 (cyclo[(Met-Asp-Trp-Phe-Dap-Leu) cyclo (2beta-5beta)]), a selective tachykinin NK2 receptor antagonist, did not abolish the endothelin-1 effect on the inhibitory response to capsaicin.	Capsaicin	38-47	endothelin 1	Homo sapiens	4-16
9932722-9	1999	The endothelin-1-induced block of the capsaicin effect was resistant to tetrodotoxin (1 microM) and 30-min pre-treatment with MEN 10.627 (cyclo[(Met-Asp-Trp-Phe-Dap-Leu) cyclo (2beta-5beta)]), a selective tachykinin NK2 receptor antagonist, did not abolish the endothelin-1 effect on the inhibitory response to capsaicin.	Capsaicin	38-47	death associated protein	Homo sapiens	161-164
9932722-9	1999	The endothelin-1-induced block of the capsaicin effect was resistant to tetrodotoxin (1 microM) and 30-min pre-treatment with MEN 10.627 (cyclo[(Met-Asp-Trp-Phe-Dap-Leu) cyclo (2beta-5beta)]), a selective tachykinin NK2 receptor antagonist, did not abolish the endothelin-1 effect on the inhibitory response to capsaicin.	Capsaicin	38-47	endothelin 1	Homo sapiens	261-273
9932722-9	1999	The endothelin-1-induced block of the capsaicin effect was resistant to tetrodotoxin (1 microM) and 30-min pre-treatment with MEN 10.627 (cyclo[(Met-Asp-Trp-Phe-Dap-Leu) cyclo (2beta-5beta)]), a selective tachykinin NK2 receptor antagonist, did not abolish the endothelin-1 effect on the inhibitory response to capsaicin.	Capsaicin	311-320	endothelin 1	Homo sapiens	4-16
9932722-10	1999	These results suggest that endothelin-1 selectively inhibits the capsaicin-induced release of neurotransmitters from rat vas deferens and these effects are mediated via endothelin ET(A) receptors but not by tachykinin release.	Capsaicin	65-74	endothelin 1	Rattus norvegicus	27-39
10077235-15	1999	These results suggest that capsaicin-sensitive, small-sized DRG neurons expressed mainly the homomeric P2X3 subunit and that capsaicin-insensitive, medium-sized DRG neurons expressed the heteromultimeric receptor with P2X2 and P2X3.	Capsaicin	27-36	purinergic receptor P2X 3	Rattus norvegicus	103-107
9886355-0	1999	Effect of omega-conotoxin GVIA and omega-agatoxin IVA on the capsaicin-sensitive calcitonin gene-related peptide release and autoregulatory vasodilation in rat pial arteries.	Capsaicin	61-70	calcitonin-related polypeptide alpha	Rattus norvegicus	81-112
9886355-3	1999	The vasodilation of pial artery induced by either CGRP (0.1 micromol/L) or capsaicin (0.3 micromol/L) was significantly inhibited by CGRP(8-37) (0.1 micromol/L) (P < 0.05 and P < 0.05, respectively).	Capsaicin	75-84	calcitonin-related polypeptide alpha	Rattus norvegicus	133-137
9886355-7	1999	These results suggest that the neuronal N- and P-type voltage-sensitive Ca2+ channels are implicated in the release of CGRP from capsaicin-sensitive perivascular sensory nerves in response to acute hypotension, and that the released CGRP may contribute to the autoregulatory vasodilation in the cerebral microcirculation.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	119-123
9886355-7	1999	These results suggest that the neuronal N- and P-type voltage-sensitive Ca2+ channels are implicated in the release of CGRP from capsaicin-sensitive perivascular sensory nerves in response to acute hypotension, and that the released CGRP may contribute to the autoregulatory vasodilation in the cerebral microcirculation.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	233-237
10457322-1	1999	Ablation of a-calcitonin gene-related polypeptide (CGRP) containing neurons with the afferent neurotoxin capsaicin improves postoperative foregut transit in a rodent model.	Capsaicin	105-114	calcitonin-related polypeptide alpha	Rattus norvegicus	51-55
10457322-10	1999	The alpha-CGRP antibody sped postoperative transit when given alone or in combination with capsaicin.	Capsaicin	91-100	calcitonin related polypeptide alpha	Homo sapiens	10-14
10391448-0	1999	Peripheral inflammation increases the capsaicin sensitivity of dorsal root ganglion neurons in a nerve growth factor-dependent manner.	Capsaicin	38-47	nerve growth factor	Rattus norvegicus	97-116
10378865-3	1999	Moreover, SP markedly increased the percentage of CD5+ and CD4+ T lymphocytes in the peripheral blood of capsaicin-treated rats.	Capsaicin	105-114	Cd5 molecule	Rattus norvegicus	50-53
10378865-3	1999	Moreover, SP markedly increased the percentage of CD5+ and CD4+ T lymphocytes in the peripheral blood of capsaicin-treated rats.	Capsaicin	105-114	Cd4 molecule	Rattus norvegicus	59-62
10378865-4	1999	Concomitant administration of SP with the non-peptide Neurokinin-1 receptor (NK1R) antagonist SR140333 completely inhibited the SP-mediated augmentation of Con A-induced PBL proliferation and IL-2 production as well as of CD4+ CD25+ and CD4+ RT1B+ T cell numbers in normal and capsaicin-treated rats.	Capsaicin	277-286	tachykinin receptor 1	Homo sapiens	77-81
10378865-5	1999	SR 140333 also blocked the increased percentage of peripheral blood CD4+ T cells induced by SP in capsaicin-treated rats.	Capsaicin	98-107	Cd4 molecule	Rattus norvegicus	68-71
10210271-6	1999	After pretreatment with capsaicin (50 mg x kg(-1), s.c.) to deplete endogenous CGRP, the preconditioning effect was absent.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
10391448-2	1999	The sensitivity of primary sensory neurons to the neurotoxin capsaicin is regulated in vitro by nerve growth factor and we have now investigated the effect of complete Freund"s adjuvant-induced inflammation on the capsaicin sensitivity of adult rat sensory neurons.	Capsaicin	61-70	nerve growth factor	Rattus norvegicus	96-115
10632027-8	1999	These results are compatible with the hypothesis that activity in capsaicin-sensitive, nociceptive primary afferent neurons evokes a central neuronal inhibitory process that prevents or reduces the itch and mechanically evoked dysesthesiae normally produced by an intradermal injection of histamine.	Capsaicin	66-75	itchy E3 ubiquitin protein ligase	Homo sapiens	198-202
10540919-1	1999	Calcitonin gene-related peptide (CGRP) and substance P co-exist in capsaicin-sensitive primary sensory neurons and are released from the myocardium after activation of sensory nerve fibres as well as by ischemia in animals.	Capsaicin	67-76	calcitonin related polypeptide alpha	Homo sapiens	0-31
10540919-1	1999	Calcitonin gene-related peptide (CGRP) and substance P co-exist in capsaicin-sensitive primary sensory neurons and are released from the myocardium after activation of sensory nerve fibres as well as by ischemia in animals.	Capsaicin	67-76	calcitonin related polypeptide alpha	Homo sapiens	33-37
9843720-7	1998	In vivo studies demonstrated a marked increase in microvascular ICAM-1 immunostaining 24 and 48 h after application of capsaicin to the skin.	Capsaicin	119-128	intercellular adhesion molecule 1	Homo sapiens	64-70
9882597-1	1999	Recent experiments have shown that human bronchial epithelial cells (i.e., BEAS-2B) release pro-inflammatory cytokines (i.e., IL-6 and TNFalpha) in a receptor-mediated fashion in response to the neuropeptides, substance P (SP), calcitonin gene-related protein (CGRP), and the prototype botanical irritant capsaicin.	Capsaicin	305-314	interleukin 6	Homo sapiens	126-143
9817783-10	1998	We propose that temperature- and capsaicin-sensitive nerve fibers release CGRP to attenuate the NIT of brown adipocytes.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
9877482-0	1998	Subthreshold concentration of endothelin-1-enhanced, capsaicin-induced bronchoconstriction in anaesthetized guinea-pigs.	Capsaicin	53-62	endothelin-1	Cavia porcellus	30-42
9877482-3	1998	This study determined these effects of ET-1 on capsaicin-induced bronchoconstriction in anaesthetized guinea-pigs.	Capsaicin	47-56	endothelin-1	Cavia porcellus	39-43
9877482-5	1998	However, this subthreshold concentration of ET-1 potentiated capsaicin-induced bronchoconstriction.	Capsaicin	61-70	endothelin-1	Cavia porcellus	44-48
9877482-6	1998	In addition, the potentiation of capsaicin-induced bronchoconstriction by this subthreshold concentration of ET-1 was completely abolished by BQ788 (ET(B) receptor antagonist), but not BQ123 (ET(A) receptor antagonists).	Capsaicin	33-42	endothelin-1	Cavia porcellus	109-113
9870571-5	1998	Large amounts of LPS however increased the number of capsaicin-induced c-fos positive cells in the TNC I,II.	Capsaicin	53-62	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-76
9815036-8	1998	These results show that kainic acid injected into the Rpa at a dose that did not stimulate acid secretion, due to the inhibitory effect of prostaglandins, protects against ethanol-induced gastric injury through vagal-dependent activation of CGRP contained in capsaicin-sensitive afferents and nitric oxide-mediated gastric vasodilatory mechanisms.	Capsaicin	259-268	calcitonin-related polypeptide alpha	Rattus norvegicus	241-245
9817376-13	1998	SP, NKA and CGRP reached 0.06+/-0.01, 0.07+/-0.01 and 0.44+/-0.18 pmol/bladder 2 weeks after capsaicin treatment in spinalized animals.	Capsaicin	93-102	calcitonin-related polypeptide alpha	Rattus norvegicus	12-16
28976666-2	1998	Peripheral mediators involve the efferent function of capsaicin-sensitive splanchnic afferents leading to calcitonin gene-related peptide (CGRP)- and nitric oxide (NO)-dependent gastric vasodilatory mechanisms.	Capsaicin	54-63	calcitonin-related polypeptide alpha	Rattus norvegicus	106-137
9819168-2	1998	The present investigation examined the thermal and metabolic responses in males who were fed capsaicin (CAP: 2 mg.kg(-1) body weight) vs. a placebo (PL: a maltodextrin capsule) prior to immersion in cold water.	Capsaicin	93-102	cyclase associated actin cytoskeleton regulatory protein 2	Rattus norvegicus	104-110
9824460-5	1998	In rats that had received neonatal capsaicin treatment, the number of P2X3-positive neurons was decreased by approximately 70%.	Capsaicin	35-44	purinergic receptor P2X 3	Rattus norvegicus	70-74
9824460-7	1998	In dorsal horn of rat spinal cord, P2X3-ir was observed in the inner portion of lamina II and was reduced subsequent to dorsal rhizotomy, as well as subsequent to neonatal capsaicin treatment.	Capsaicin	172-181	purinergic receptor P2X 3	Rattus norvegicus	35-39
9769424-15	1998	Indeed, reducing CGRP content by capsaicin pre-treatment or prior denervation prevented both the excitation-induced force recovery and the drop in intracellular Na+.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
9808699-4	1998	In the present study, the role of capsaicin-sensitive neurons and sensory neuropeptides in the VN1/VN2 receptor actions of capsaicin was investigated.	Capsaicin	34-43	vomeronasal 1 receptor 105	Rattus norvegicus	95-98
9808699-4	1998	In the present study, the role of capsaicin-sensitive neurons and sensory neuropeptides in the VN1/VN2 receptor actions of capsaicin was investigated.	Capsaicin	34-43	vomeronasal 1 receptor 102	Rattus norvegicus	99-102
9808699-4	1998	In the present study, the role of capsaicin-sensitive neurons and sensory neuropeptides in the VN1/VN2 receptor actions of capsaicin was investigated.	Capsaicin	123-132	vomeronasal 1 receptor 105	Rattus norvegicus	95-98
9808699-4	1998	In the present study, the role of capsaicin-sensitive neurons and sensory neuropeptides in the VN1/VN2 receptor actions of capsaicin was investigated.	Capsaicin	123-132	vomeronasal 1 receptor 102	Rattus norvegicus	99-102
9808699-16	1998	These data suggest that capsaicin-sensitive neurons, presumably via release of SP and NKA, are involved in VN1 responses and that capsaicin pretreatment potentiates VN2 responses, either by depletion of CGRP reserves or by upregulation of putative VN2 receptors.	Capsaicin	24-33	Natural killer alloreactivity QTL 1	Rattus norvegicus	86-89
9808699-16	1998	These data suggest that capsaicin-sensitive neurons, presumably via release of SP and NKA, are involved in VN1 responses and that capsaicin pretreatment potentiates VN2 responses, either by depletion of CGRP reserves or by upregulation of putative VN2 receptors.	Capsaicin	24-33	vomeronasal 1 receptor 105	Rattus norvegicus	107-110
9808699-16	1998	These data suggest that capsaicin-sensitive neurons, presumably via release of SP and NKA, are involved in VN1 responses and that capsaicin pretreatment potentiates VN2 responses, either by depletion of CGRP reserves or by upregulation of putative VN2 receptors.	Capsaicin	130-139	vomeronasal 1 receptor 102	Rattus norvegicus	165-168
9808699-16	1998	These data suggest that capsaicin-sensitive neurons, presumably via release of SP and NKA, are involved in VN1 responses and that capsaicin pretreatment potentiates VN2 responses, either by depletion of CGRP reserves or by upregulation of putative VN2 receptors.	Capsaicin	130-139	calcitonin-related polypeptide alpha	Rattus norvegicus	203-207
9808699-16	1998	These data suggest that capsaicin-sensitive neurons, presumably via release of SP and NKA, are involved in VN1 responses and that capsaicin pretreatment potentiates VN2 responses, either by depletion of CGRP reserves or by upregulation of putative VN2 receptors.	Capsaicin	130-139	vomeronasal 1 receptor 102	Rattus norvegicus	248-251
9787000-6	1998	There was nearly complete degeneration of epidermal nerve fibers and the subepidermal neural plexus in capsaicin-treated skin, as indicated by the loss of immunoreactivity for PGP 9.5 and CGRP.	Capsaicin	103-112	ubiquitin C-terminal hydrolase L1	Homo sapiens	176-183
9787000-6	1998	There was nearly complete degeneration of epidermal nerve fibers and the subepidermal neural plexus in capsaicin-treated skin, as indicated by the loss of immunoreactivity for PGP 9.5 and CGRP.	Capsaicin	103-112	calcitonin related polypeptide alpha	Homo sapiens	188-192
28976666-2	1998	Peripheral mediators involve the efferent function of capsaicin-sensitive splanchnic afferents leading to calcitonin gene-related peptide (CGRP)- and nitric oxide (NO)-dependent gastric vasodilatory mechanisms.	Capsaicin	54-63	calcitonin-related polypeptide alpha	Rattus norvegicus	139-143
9787000-7	1998	The effect of capsaicin on dermal nerve fibers immunoreactive for SP was less obvious.	Capsaicin	14-23	tachykinin precursor 1	Homo sapiens	66-68
9721162-0	1998	Gastric acid-evoked c-fos messenger RNA expression in rat brainstem is signaled by capsaicin-resistant vagal afferents.	Capsaicin	83-92	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	20-25
9840425-9	1998	These results indicate that ET-1 may play a role in the development of bronchial hyperresponsiveness to inhaled histamine and that the maintenance of this state is unrelated to a detectable alteration in cellular infiltration within the airway lumen, but probably via the involvement of capsaicin-sensitive nerves.	Capsaicin	287-296	endothelin-1	Oryctolagus cuniculus	28-32
9756514-2	1998	This study assesses the role of capsaicin-sensitive primary afferents (CSPA) and the myenteric plexus in the inhibition of rat jejunal alanine absorption by VIP.	Capsaicin	32-41	vasoactive intestinal peptide	Rattus norvegicus	157-160
9756514-7	1998	In the presence of 40 nM VIP, alanine uptake by full-thickness jejunal strips was reduced by 54% in sham control rats and by 25% in rats neonatally treated with capsaicin (P < 0.001).	Capsaicin	161-170	vasoactive intestinal peptide	Rattus norvegicus	25-28
9875565-5	1998	In the NGF group, the percentage of neurons sensitive to BK was significantly greater among capsaicin (CAP)-sensitive than among CAP-insensitive neurons (48 vs 20%).	Capsaicin	92-101	nerve growth factor	Rattus norvegicus	7-10
9875565-5	1998	In the NGF group, the percentage of neurons sensitive to BK was significantly greater among capsaicin (CAP)-sensitive than among CAP-insensitive neurons (48 vs 20%).	Capsaicin	103-106	nerve growth factor	Rattus norvegicus	7-10
9875565-8	1998	These results demonstrate that NGF increases sensitivity to BK, mediated through B2 receptors only, in capsaicin-sensitive small neurons cultured from rat DRGs.	Capsaicin	103-112	nerve growth factor	Rattus norvegicus	31-34
9832191-2	1998	Bath-applied capsaicin at a concentration of 2 microM activated a slow inward current (having an amplitude of 33 pA at -70 mV), which was accompanied by an increase in the frequency of glutamatergic spontaneous excitatory postsynaptic currents (sEPSCs; by 234%); these actions were blocked by a capsaicin-receptor antagonist, capsazepine (10 microM).	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	295-313
9801167-7	1998	Pseudocapsaicin, but not capsaicin, also selectively bound to CB1 receptor-containing membranes.	Capsaicin	6-15	cannabinoid receptor 1	Rattus norvegicus	62-65
9733366-0	1998	Aggravation of myocardial infarction in the porcine heart by capsaicin-induced depletion of calcitonin gene-related peptide (CGRP).	Capsaicin	61-70	Calcitonin gene-related peptide	Sus scrofa	92-123
9733366-0	1998	Aggravation of myocardial infarction in the porcine heart by capsaicin-induced depletion of calcitonin gene-related peptide (CGRP).	Capsaicin	61-70	Calcitonin gene-related peptide	Sus scrofa	125-129
9733366-1	1998	The potent vasodilator calcitonin gene-related peptide (CGRP) is stored in a population of C-fiber afferents that are sensitive to capsaicin.	Capsaicin	131-140	Calcitonin gene-related peptide	Sus scrofa	23-54
9733366-1	1998	The potent vasodilator calcitonin gene-related peptide (CGRP) is stored in a population of C-fiber afferents that are sensitive to capsaicin.	Capsaicin	131-140	Calcitonin gene-related peptide	Sus scrofa	56-60
9733366-8	1998	Capsaicin-treated pigs had more extensive myocardial infarction (56+/-6% vs. 26+/-8% of the area at risk; p=0.013) and a lower myocardial content of CGRP (14+/-6 vs. 32+/-5 pmol/g; p=0.039) compared with six untreated control pigs.	Capsaicin	0-9	Calcitonin gene-related peptide	Sus scrofa	149-153
9808370-7	1998	These results show that NGF is responsible for the development of an increased noradrenergic innervation in the rat ureter after neonatal capsaicin treatment.	Capsaicin	138-147	nerve growth factor	Rattus norvegicus	24-27
10375815-5	1998	The protection of ischemic preconditioning was abolished by repeated pretreatments with capsaicin to deplete CGRP.	Capsaicin	88-97	calcitonin-related polypeptide alpha	Rattus norvegicus	109-113
10375815-6	1998	Acute application of capsaicin to evoke CGRP release or CGRP caused an ischemic preconditioning-like protection.	Capsaicin	21-30	calcitonin-related polypeptide alpha	Rattus norvegicus	40-44
10375815-6	1998	Acute application of capsaicin to evoke CGRP release or CGRP caused an ischemic preconditioning-like protection.	Capsaicin	21-30	calcitonin-related polypeptide alpha	Rattus norvegicus	56-60
10375815-7	1998	CONCLUSION: Capsaicin-sensitive sensory nerves are involved in the protective effect of ischemic preconditioning on endothelial cells in the rat hindlimbs, and CGRP can mimic the protective effect of ischemic preconditioning in blood vessels.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	160-164
9808369-6	1998	In TNBS treated groups, inflammation was enhanced by capsaicin pretreatment, as determined by an increased gut permeability, MPO activity, and histological damage score.	Capsaicin	53-62	myeloperoxidase	Rattus norvegicus	125-128
9808370-0	1998	Involvement of NGF in the induction of increased noradrenergic innervation of the ureter in neonatally capsaicin-treated rats.	Capsaicin	103-112	nerve growth factor	Rattus norvegicus	15-18
9723972-10	1998	Nociceptin almost totally abolished the reflex component of the response to topical capsaicin (1 microg in 50 microl).	Capsaicin	84-93	prepronociceptin	Rattus norvegicus	0-10
9808370-4	1998	Injections of an anti-NGF antiserum during postnatal days (PN) PN 8-14, PN 13-19 or during PN 17-23 counteracted the capsaicin effect and reduced noradrenaline towards control levels.	Capsaicin	117-126	nerve growth factor	Rattus norvegicus	22-25
9808370-5	1998	Immunohistochemical localization of tyrosine hydroxylase (TH), a marker for sympathetic nerve fibres, revealed that the capsaicin-induced hyperinnervation was mainly represented by fibres in deeper muscle layers and to a smaller extent by fibres in the submucosa.	Capsaicin	120-129	tyrosine hydroxylase	Rattus norvegicus	36-56
9808370-5	1998	Immunohistochemical localization of tyrosine hydroxylase (TH), a marker for sympathetic nerve fibres, revealed that the capsaicin-induced hyperinnervation was mainly represented by fibres in deeper muscle layers and to a smaller extent by fibres in the submucosa.	Capsaicin	120-129	tyrosine hydroxylase	Rattus norvegicus	58-60
9723950-15	1998	The amount of CGRP released in the isolated stomach in response to capsaicin was significantly lower in diabetic rats when compared to controls.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	14-18
9881874-4	1998	Intradermal injection of capsaicin or formalin also increased Fos-positive neurons.	Capsaicin	25-34	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-65
9881874-5	1998	Capsaicin- or formalin-induced Fos expression was reduced in both cases by pretreatment of capsazepine, but to a much lesser extent for formalin.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-34
9729242-3	1998	Latexin was widely distributed in the cytoplasm of the cell body and in axonal fibers of cultured DRG neurons which were sensitive to capsaicin.	Capsaicin	134-143	latexin	Rattus norvegicus	0-7
9698167-1	1998	In the present study, we investigated the changes in capsaicin- and endotoxin-induced calcitonin gene-related peptide (CGRP) release from mesenteric arterial bed (MAB) and spinal cord slices (SCS) in 2-month-old and 18-month-old Wistar rats.	Capsaicin	53-62	calcitonin-related polypeptide alpha	Rattus norvegicus	86-117
9671679-4	1998	Our results suggest that the primary localization of the alpha2A-AR in the rat spinal cord is on the terminals of capsaicin-sensitive, substance P (SP)-containing primary afferent fibers.	Capsaicin	114-123	adrenoceptor alpha 2A	Rattus norvegicus	57-67
9698167-1	1998	In the present study, we investigated the changes in capsaicin- and endotoxin-induced calcitonin gene-related peptide (CGRP) release from mesenteric arterial bed (MAB) and spinal cord slices (SCS) in 2-month-old and 18-month-old Wistar rats.	Capsaicin	53-62	calcitonin-related polypeptide alpha	Rattus norvegicus	119-123
9698167-5	1998	Either basal or stimulated CGRP release induced by capsaicin and endotoxin was significantly decreased as the rats aged from 2 to 18 months.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	27-31
9698167-7	1998	The release of CGRP evoked by capsaicin (10(-7) mol/L) and endotoxin (1 to approximately 5 microg/ml) from MAB and SCS was significantly decreased by more than 50% in 18-month-old rats.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
9698167-8	1998	These data suggest that both the basal and capsaicin- or endotoxin-stimulated CGRP release from MAB and SCS display a significant decrement in aged rats that may have some physiological, pathological, and behavioural relevance in age-related diseases.	Capsaicin	43-52	calcitonin-related polypeptide alpha	Rattus norvegicus	78-82
9655678-4	1998	However, this method has recently been called into question by research demonstrating that the molecular target of capsaicin on spinal and trigeminal afferents, vanilloid receptor subtype 1 (VR1), is absent from vagal afferents.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	161-189
9708861-0	1998	Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	63-93
9708861-0	1998	Capsaicin sensitivity is associated with the expression of the vanilloid (capsaicin) receptor (VR1) mRNA in adult rat sensory ganglia.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	95-98
9708861-1	1998	A vanilloid receptor (VR1) has recently been cloned and shown to be a target for capsaicin, the excitotoxic component of capsicum peppers (Caterina, M.J., Schumacher, M.A., Tominaga, M., Rosen, T.A., Levine, J.D.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-25
9666148-0	1998	Increased spinal release of excitatory amino acids following intradermal injection of capsaicin is reduced by a protein kinase G inhibitor.	Capsaicin	86-95	protein kinase cGMP-dependent 1	Homo sapiens	112-128
9666148-8	1998	The increase in aspartate and glutamate concentrations that occurs after capsaicin injection was reduced back to baseline after spinal infusion of the PKG inhibitor, KT5823.	Capsaicin	73-82	protein kinase cGMP-dependent 1	Homo sapiens	151-154
9655678-4	1998	However, this method has recently been called into question by research demonstrating that the molecular target of capsaicin on spinal and trigeminal afferents, vanilloid receptor subtype 1 (VR1), is absent from vagal afferents.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	191-194
9655680-2	1998	Recently, it was reported that secretin inhibited gastric emptying via a capsaicin (Cap)-sensitive vagal afferent pathway.	Capsaicin	73-82	secretin	Rattus norvegicus	31-39
9655680-2	1998	Recently, it was reported that secretin inhibited gastric emptying via a capsaicin (Cap)-sensitive vagal afferent pathway.	Capsaicin	84-87	secretin	Rattus norvegicus	31-39
17038971-2	1998	It is no coincidence that during the same period the capsaicin receptor was cloned and named the vanilloid receptor subtype 1 and the European dual centre study of intravesical capsaicin reported that overall 80% of patients derived some clinical benefit.	Capsaicin	53-62	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-125
9688979-1	1998	This study examined the renal nerve-dependent renal hemodynamic and tubular responses to somatosensory stimulation in the anesthetized rat by use of subcutaneously applied capsaicin when the action of ANG II was blocked peripherally or selectively within the brain.	Capsaicin	172-181	angiotensinogen	Rattus norvegicus	201-207
17038971-3	1998	In spite of this, ultrapotent capsaicin analogues such as resiniferatoxin, which also interact with the vanilloid receptor subtype 1, are being studied.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-132
9699986-1	1998	The partitioning behaviour of a drug (capsaicin)-responsive NADH oxidase (tNOX) activity released from HeLa cells by low pH treatment followed by heat and proteinase K was determined.	Capsaicin	38-47	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	74-78
9698200-0	1998	Effects of endothelin-1 on capsaicin-induced nociception in mice.	Capsaicin	27-36	endothelin 1	Mus musculus	11-23
9698200-1	1998	The influence of endothelin-1 on nociception induced by capsaicin was assessed in the mouse hindpaw.	Capsaicin	56-65	endothelin 1	Mus musculus	17-29
9698200-2	1998	Local endothelin-1 injection (1 to 20 pmol/paw) 30 min prior to ipsilateral injection of capsaicin (0.1 microg/paw) increased, in a graded fashion, the time spent licking the injected paw.	Capsaicin	89-98	endothelin 1	Mus musculus	6-18
9698200-3	1998	Maximal hyperalgesia was obtained with 10 pmol/paw of endothelin-1 (capsaicin-induced hindpaw licking time increased from 43 +/- 3 s to 114 +/- 7 s, n = 6), but no hyperalgesia was evident following 30 pmol/paw of endothelin-1.	Capsaicin	68-77	endothelin 1	Mus musculus	54-66
9698200-3	1998	Maximal hyperalgesia was obtained with 10 pmol/paw of endothelin-1 (capsaicin-induced hindpaw licking time increased from 43 +/- 3 s to 114 +/- 7 s, n = 6), but no hyperalgesia was evident following 30 pmol/paw of endothelin-1.	Capsaicin	68-77	endothelin 1	Mus musculus	214-226
9698200-9	1998	Therefore, local endothelin-1 exerts a dual influence in this model: at low doses it causes endothelin ET(A) receptor-mediated hyperalgesia (i.e., it potentiates capsaicin-induced nociception), whereas at higher doses it induces an anti-hyperalgesic effect against 5-HT which seems to be mediated via distinct endothelin ET (possibly ET(B)) receptors.	Capsaicin	162-171	endothelin 1	Mus musculus	17-29
9753087-11	1998	Blocking the MAP kinase cascade using a MEK1/2 inhibitor, PD98059, abrogated NGF dependent capsaicin sensitivity, a nociceptive property specific to sensory neurons.	Capsaicin	91-100	mitogen activated protein kinase kinase 1	Rattus norvegicus	40-46
9705161-11	1998	Itch sensations in capsaicin-pretreated skin were significantly lower in control subjects than in AE patients.	Capsaicin	19-28	itchy E3 ubiquitin protein ligase	Homo sapiens	0-4
9612278-6	1998	These results indicate that protective effects of peptone involve endogenous gastrin and possibly somatostatin and are mediated by capsaicin-sensitive afferent, cholinergic, and bombesin/GRP neurons.	Capsaicin	131-140	gastrin releasing peptide	Rattus norvegicus	187-190
9601677-5	1998	DRG ASIC-ir co-localizes with substance P (SP) and calcitonin gene-related peptide (CGRP)-ir in small capsaicin-sensitive cell bodies, suggesting that ASIC is poised to play a role in the transduction of noxious stimuli.	Capsaicin	102-111	calcitonin-related polypeptide alpha	Rattus norvegicus	84-88
9612376-5	1998	Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 +/- 3.9 microns2/mm2; capsaicin treated, 31.4 +/- 2.8 microns2/mm2, P = 0.01; control CaR density, 46 +/- 4 microns2/mm2, n = 7; capsaicin-treated CaR density, 24 +/- 4 microns2/mm2, n = 8, P = 0.002).	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	127-158
9612376-5	1998	Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 +/- 3.9 microns2/mm2; capsaicin treated, 31.4 +/- 2.8 microns2/mm2, P = 0.01; control CaR density, 46 +/- 4 microns2/mm2, n = 7; capsaicin-treated CaR density, 24 +/- 4 microns2/mm2, n = 8, P = 0.002).	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	160-164
9612376-5	1998	Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 +/- 3.9 microns2/mm2; capsaicin treated, 31.4 +/- 2.8 microns2/mm2, P = 0.01; control CaR density, 46 +/- 4 microns2/mm2, n = 7; capsaicin-treated CaR density, 24 +/- 4 microns2/mm2, n = 8, P = 0.002).	Capsaicin	39-48	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	178-181
9612376-5	1998	Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 +/- 3.9 microns2/mm2; capsaicin treated, 31.4 +/- 2.8 microns2/mm2, P = 0.01; control CaR density, 46 +/- 4 microns2/mm2, n = 7; capsaicin-treated CaR density, 24 +/- 4 microns2/mm2, n = 8, P = 0.002).	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	183-187
9612376-5	1998	Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 +/- 3.9 microns2/mm2; capsaicin treated, 31.4 +/- 2.8 microns2/mm2, P = 0.01; control CaR density, 46 +/- 4 microns2/mm2, n = 7; capsaicin-treated CaR density, 24 +/- 4 microns2/mm2, n = 8, P = 0.002).	Capsaicin	39-48	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	297-300
9612376-5	1998	Immunocytochemical studies showed that capsaicin treatment significantly reduced the density of nerves staining positively for calcitonin gene-related peptide (CGRP) and for the CaR (CGRP density: control, 51.1 +/- 3.9 microns2/mm2; capsaicin treated, 31.4 +/- 2.8 microns2/mm2, P = 0.01; control CaR density, 46 +/- 4 microns2/mm2, n = 7; capsaicin-treated CaR density, 24 +/- 4 microns2/mm2, n = 8, P = 0.002).	Capsaicin	39-48	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	297-300
9657352-0	1998	Sensory CGRP depletion by capsaicin exacerbates hypoxia-induced pulmonary hypertension in rats.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	8-12
9657352-9	1998	Because of the limited effects on these parameters by substance P and other capsaicin-sensitive lung agents, our results suggest that sensory CGRP deficit severely exacerbates pathological signs of hypoxic pulmonary hypertension.	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	142-146
9612376-7	1998	These data support the hypothesis that Ca(2+)-induced relaxation is mediated by activation of the CaR associated with capsaicin-sensitive perivascular neurons.	Capsaicin	118-127	nuclear receptor subfamily 1, group I, member 3	Rattus norvegicus	98-101
9643615-8	1998	Prolonged capsaicin pretreatment inhibited endothelin-1 induced vasodilation in the area surrounding the injection site, but not the central vasoconstriction at the injection site.	Capsaicin	10-19	endothelin 1	Homo sapiens	43-55
9696479-0	1998	The NMDA receptor antagonist MK-801 reduces capsaicin-induced c-fos expression within rat trigeminal nucleus caudalis.	Capsaicin	44-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
9696479-8	1998	30 min before capsaicin (5 nmol in 100 microl artificial CSF) reduced significantly and dose-dependently (12%, 36% and 47%, respectively) the c-fos-LI cells in TNC at each level from rostral to caudal but not in solitary tract, area postrema and lateral reticular nuclei, and for unexplained reasons, increased c-fos-LI within the inferior olive.	Capsaicin	14-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	142-147
9650854-3	1998	Release of sensory neuropeptides such as substance P, calcitonin gene-related peptide (CGRP) and somatostatin from the rat isolated trachea in response to capsaicin (10(-8) M) or bradykinin (10(-7) M) were also attenuated by nociceptin (100 and 300 nM).	Capsaicin	155-164	calcitonin-related polypeptide alpha	Rattus norvegicus	54-85
9650854-3	1998	Release of sensory neuropeptides such as substance P, calcitonin gene-related peptide (CGRP) and somatostatin from the rat isolated trachea in response to capsaicin (10(-8) M) or bradykinin (10(-7) M) were also attenuated by nociceptin (100 and 300 nM).	Capsaicin	155-164	calcitonin-related polypeptide alpha	Rattus norvegicus	87-91
9650854-4	1998	It is concluded that chemically induced discharge of mediators from mast cells and from capsaicin-sensitive afferent nerve terminals are both inhibited by nociceptin that participates in the anti-inflammatory effect of the peptide.	Capsaicin	88-97	prepronociceptin	Rattus norvegicus	155-165
9613798-0	1998	The effect of noradrenaline, angiotensin II and vasopressin on blood flow and sensitivity to heat in capsaicin-treated skin.	Capsaicin	101-110	arginine vasopressin	Homo sapiens	48-59
9502264-0	1998	Pituitary adenylate cyclase activating polypeptide immunoreactivity in capsaicin-sensitive nerve fibres supplying the rat urinary tract.	Capsaicin	71-80	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-50
9656888-1	1998	The aim of this investigation was to determine the temporal effect of an intra-articular injection of capsaicin to the temporomandibular joint on the levels of calcitonin gene-related peptide-like immunoreactivity (CGRP-ir) in the trigeminal ganglion of the rat.	Capsaicin	102-111	calcitonin-related polypeptide alpha	Rattus norvegicus	215-219
9656888-6	1998	Results demonstrated that when the capsaicin-treated side and the vehicle-treated side were compared, CGRP-ir levels decreased initially at 4 hours and increased at 48 hours.	Capsaicin	35-44	calcitonin-related polypeptide alpha	Rattus norvegicus	102-106
9656888-8	1998	CGRP-ir levels for the first two time periods investigated, which simulate an acute inflammatory state, mimic results observed in studies using limb joints, while the other time periods, which represent an intermediate and a chronic condition, respectively, suggest a more complex interaction with capsaicin-sensitive primary afferents.	Capsaicin	298-307	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
9855048-1	1998	Capsaicin exerts its gastroprotective effect by stimulating primary afferent neurons, releasing calcitonin gene-related peptide (CGRP), which in turn increases gastric blood flow.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	96-127
9855048-1	1998	Capsaicin exerts its gastroprotective effect by stimulating primary afferent neurons, releasing calcitonin gene-related peptide (CGRP), which in turn increases gastric blood flow.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	129-133
9855048-10	1998	The defence mechanism of capsaicin against gastric cell injury may in part be mediated by a direct effect of CGRP on gastric mucosal cells, in addition to effects dependent on neural and vascular mechanisms.	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	109-113
9473216-1	1998	Secretoneurin (SN), a 33-amino acid neuropeptide, is derived from secretogranin II that is released from sensory afferent C-fibers by capsaicin.	Capsaicin	134-143	secretogranin II	Homo sapiens	0-13
9600661-16	1998	Moreover, the effects of endothelin-1 were attenuated in capsaicin pretreated rats (125 mg/kg, 10 days earlier) and almost abolished in rats subjected to sympathectomy with 6-hydroxydopamine (100 mg/kg, 24-48 h earlier).	Capsaicin	57-66	endothelin 1	Rattus norvegicus	25-37
9578933-6	1998	rNEP reduced the increase in nasal plasma exudation evoked by capsaicin (endogenous neuropeptides).	Capsaicin	62-71	membrane metallo-endopeptidase	Rattus norvegicus	0-4
9580328-5	1998	Capsaicin and resiniferatoxin were found to activate both isoforms of c-jun-NH2-kinase (JNK), with a maximal activity after 30 min of treatment.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	70-86
9580328-5	1998	Capsaicin and resiniferatoxin were found to activate both isoforms of c-jun-NH2-kinase (JNK), with a maximal activity after 30 min of treatment.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	88-91
9640812-2	1998	Most of the Calcitonin Gene-Related Peptide Immunoreactive (CGRP-IP) nerves have been found to be Capsaicin-sensitive suggesting an involvement in certain types of pain.	Capsaicin	98-107	calcitonin-related polypeptide alpha	Rattus norvegicus	12-43
9640812-2	1998	Most of the Calcitonin Gene-Related Peptide Immunoreactive (CGRP-IP) nerves have been found to be Capsaicin-sensitive suggesting an involvement in certain types of pain.	Capsaicin	98-107	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
9577339-0	1998	Role of capsaicin sensitive nerves in epidermal growth factor effects on gastric mucosal injury and blood flow.	Capsaicin	8-17	epidermal growth factor like 1	Rattus norvegicus	38-61
9577339-2	1998	Capsaicin exerts its gastroprotective effect by stimulating afferent neurones leading to release of calcitonin gene related peptide (CGRP) which causes gastric hyperaemia.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	100-131
9577339-2	1998	Capsaicin exerts its gastroprotective effect by stimulating afferent neurones leading to release of calcitonin gene related peptide (CGRP) which causes gastric hyperaemia.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	133-137
9577339-4	1998	AIMS: To assess the influence of: (1) capsaicin desensitisation on EGF effects on gastric mucosal injury and gastric mucosal blood flow: and (2) close arterial infusion of hCGRP8-379, a CGRP antagonist, on EGF effects on gastric mucosal blood flow.	Capsaicin	38-47	epidermal growth factor like 1	Rattus norvegicus	67-70
9577339-8	1998	RESULTS: Capsaicin desensitisation abolished the gastroprotective and gastric hyperaemic effects of EGF.	Capsaicin	9-18	epidermal growth factor like 1	Rattus norvegicus	100-103
9577339-10	1998	CONCLUSION: Results show that EGF may exert its gastroprotective and gastric hyperaemic effects via capsaicin sensitive afferent neurones.	Capsaicin	100-109	epidermal growth factor like 1	Rattus norvegicus	30-33
9531466-3	1998	Replacement of the calcium in the bathing medium by 2 mM manganese suppressed all detectable c-fos-ir, whereas inclusion of 0.5 microM capsaicin caused intense c-fos-ir expression in the absence of stimulation.	Capsaicin	135-144	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	160-165
9476901-7	1998	CCSP-NGF mice were more sensitive than normal mice to capsaicin-induced increases in respiratory system resistance, demonstrating that the increased sensory innervation led to a change in airway function.	Capsaicin	54-63	secretoglobin, family 1A, member 1 (uteroglobin)	Mus musculus	0-4
9476901-7	1998	CCSP-NGF mice were more sensitive than normal mice to capsaicin-induced increases in respiratory system resistance, demonstrating that the increased sensory innervation led to a change in airway function.	Capsaicin	54-63	nerve growth factor	Mus musculus	5-8
9532533-1	1998	This article describes the effects of topically applied capsaicin (a nociceptive substance-P suppressor) in patients with neuropathic periocular or facial pain.	Capsaicin	56-65	tachykinin precursor 1	Homo sapiens	81-92
9539680-9	1998	Peripherally administered cannabinoids also interacted with CB1 receptors to inhibit capsaicin-evoked plasma extravasation into the hindpaw.	Capsaicin	85-94	cannabinoid receptor 1	Rattus norvegicus	60-63
9531466-6	1998	Cords obtained from animals treated at 1 day old with capsaicin to destroy afferent C fibres showed a reduction in the number of c-fos-ir positive cells induced by high intensity dorsal root stimulation.	Capsaicin	54-63	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	129-134
9508340-6	1998	Functionally, capsaicin applied to forearm skin revealed by 6 h discharge of mast cell chymase and induction of E-selectin in adjacent microvascular endothelium, events consistent with release of substance P from axons and subsequent stimulation of cytokine-mediated mast cell-endothelial interaction.	Capsaicin	14-23	selectin, endothelial cell	Mus musculus	112-122
9649293-6	1998	RESULTS: Lidocaine instilled previously markedly reduced the number of Fos-IR spinal cells responding to capsaicin-induced bladder afferent excitation.	Capsaicin	105-114	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	71-74
9649293-7	1998	Numbers of Fos-IR cells induced by acetic acid instillation in bladders desensitized by capsaicin administrated 24 hours before were not changed by lidocaine application prior to capsaicin.	Capsaicin	88-97	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-14
9394044-7	1998	Neonatal treatment with capsaicin significantly reduced the concentration of PACAP-38 in the esophagus, stomach, and colon.	Capsaicin	24-33	adenylate cyclase activating polypeptide 1	Rattus norvegicus	77-82
9502206-0	1998	Brain derived neurotrophic factor, but not nerve growth factor, regulates capsaicin sensitivity of rat vagal ganglion neurones.	Capsaicin	74-83	brain-derived neurotrophic factor	Rattus norvegicus	0-33
9502206-2	1998	This ability to respond to capsaicin is dependent on nerve growth factor (NGF) in dissociated, cultured, adult rat DRG neurones.	Capsaicin	27-36	nerve growth factor	Rattus norvegicus	53-72
9502206-2	1998	This ability to respond to capsaicin is dependent on nerve growth factor (NGF) in dissociated, cultured, adult rat DRG neurones.	Capsaicin	27-36	nerve growth factor	Rattus norvegicus	74-77
9502206-3	1998	We tested the ability of NGF (50 ng/ml) to regulate capsaicin sensitivity in a different group of sensory neurones, namely those of the vagal ganglia.	Capsaicin	52-61	nerve growth factor	Rattus norvegicus	25-28
9502206-4	1998	Capsaicin sensitivity, measured in populations of neurones by capsaicin-evoked 45Ca uptake, or in single neurones using a cobalt staining method, was apparent in vagal ganglion neurones after 1 day in culture, but after 5 days in the presence or the absence of NGF, capsaicin-stimulated 45Ca uptake was essentially abolished.	Capsaicin	0-9	nerve growth factor	Rattus norvegicus	261-264
9502206-5	1998	As some vagal ganglion neurones exhibit responses to brain derived neurotrophic factor (BDNF), we grew cells in BDNF (1 microg/ml) and found that the capsaicin sensitivity was now apparent at 5 days.	Capsaicin	150-159	brain-derived neurotrophic factor	Rattus norvegicus	53-86
9502206-5	1998	As some vagal ganglion neurones exhibit responses to brain derived neurotrophic factor (BDNF), we grew cells in BDNF (1 microg/ml) and found that the capsaicin sensitivity was now apparent at 5 days.	Capsaicin	150-159	brain-derived neurotrophic factor	Rattus norvegicus	88-92
9502206-5	1998	As some vagal ganglion neurones exhibit responses to brain derived neurotrophic factor (BDNF), we grew cells in BDNF (1 microg/ml) and found that the capsaicin sensitivity was now apparent at 5 days.	Capsaicin	150-159	brain-derived neurotrophic factor	Rattus norvegicus	112-116
9502206-6	1998	Therefore BDNF but not NGF, regulates capsaicin sensitivity in adult rat vagal ganglion neurone cultures.	Capsaicin	38-47	brain-derived neurotrophic factor	Rattus norvegicus	10-14
9458786-5	1998	These findings indicate that vagal efferent activation induced by TRH analog injected intracisternally at a gastric acid secretory dose increases GMBF through atropine-sensitive mechanisms stimulating L-arginine-nitric oxide pathways, whereas H1 receptors and capsaicin-sensitive afferent fibers do not play a role.	Capsaicin	260-269	thyrotropin releasing hormone	Rattus norvegicus	66-69
9457490-6	1998	FK224, a dual antagonist of tachykinin NK1 and NK2 receptors, and FK888, a selective antagonist of NK1 receptor, significantly inhibited capsaicin-induced plasma exudation in the pharynx.	Capsaicin	137-146	tachykinin receptor 1	Rattus norvegicus	99-111
9473857-8	1998	In hairless rats treated with systemic capsaicin, the above plasma extravasation was significantly reduced, along with SP-IRNF and CGRP-IRNF; however, protein gene product 9.5 (PGP 9.5)-IRNF was nearly intact.	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	131-135
9473857-8	1998	In hairless rats treated with systemic capsaicin, the above plasma extravasation was significantly reduced, along with SP-IRNF and CGRP-IRNF; however, protein gene product 9.5 (PGP 9.5)-IRNF was nearly intact.	Capsaicin	39-48	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	151-175
9473857-8	1998	In hairless rats treated with systemic capsaicin, the above plasma extravasation was significantly reduced, along with SP-IRNF and CGRP-IRNF; however, protein gene product 9.5 (PGP 9.5)-IRNF was nearly intact.	Capsaicin	39-48	ubiquitin C-terminal hydrolase L1	Rattus norvegicus	177-184
9508340-6	1998	Functionally, capsaicin applied to forearm skin revealed by 6 h discharge of mast cell chymase and induction of E-selectin in adjacent microvascular endothelium, events consistent with release of substance P from axons and subsequent stimulation of cytokine-mediated mast cell-endothelial interaction.	Capsaicin	14-23	tachykinin 1	Mus musculus	196-207
9435579-7	1997	PCNA labeling increased substantially in the first 72 h after injury in control animals but was significantly decreased in capsaicin-treated animals within and adjacent to the site of injury.	Capsaicin	123-132	proliferating cell nuclear antigen	Cavia porcellus	0-4
9511172-3	1998	The temporal course of cephalic cutaneous wounds in neonatally capsaicin-treated rats was evaluated in animals wearing and not wearing plastic collars from postnatal day (P) 21 until P45.	Capsaicin	63-72	caspase 1	Rattus norvegicus	183-186
9511172-5	1998	Beginning on P21, capsaicin-treated rats under both conditions showed transient skin ulcers distributed throughout the head and neck regions.	Capsaicin	18-27	KRAS proto-oncogene, GTPase	Rattus norvegicus	13-16
9511172-6	1998	In the capsaicin-treated group without collars, lesions reached their greatest severity by P40, when self-grooming and scratching behaviors obtained adult characteristics.	Capsaicin	7-16	septin 3	Rattus norvegicus	91-94
9511172-8	1998	In the capsaicin-treated rats that wore plastic collars, the widest distribution of skin lesions occurred on P55, after which time lesions vanished detection by 25 days.	Capsaicin	7-16	MAGUK p55 scaffold protein 1	Rattus norvegicus	109-112
9777631-6	1998	After neonatal capsaicin treatment, higher levels of GAD67 mRNA were detected transiently during the postnatal development of the rat spinal cord.	Capsaicin	15-24	glutamate decarboxylase 1	Rattus norvegicus	53-58
9777631-7	1998	A maximum two-fold increase of GAD67 mRNA was found on the day following the capsaicin injection and reached control values within 3 weeks.	Capsaicin	77-86	glutamate decarboxylase 1	Rattus norvegicus	31-36
9777631-10	1998	The capsaicin-induction of mRNA synthesis was, however, two-fold greater for beta-actin than for GAD67.	Capsaicin	4-13	actin, beta	Rattus norvegicus	77-87
9777631-10	1998	The capsaicin-induction of mRNA synthesis was, however, two-fold greater for beta-actin than for GAD67.	Capsaicin	4-13	glutamate decarboxylase 1	Rattus norvegicus	97-102
9777631-11	1998	Moreover, since this upregulation of GAD67 mRNA coincides with the sprouting of unaffected afferent fibers and of 5HT axons, one can hypothesize that GAD67 participates in the structural plasticity occurring in reaction to the capsaicin-induced partial deafferentation.	Capsaicin	227-236	glutamate decarboxylase 1	Rattus norvegicus	37-42
9777631-11	1998	Moreover, since this upregulation of GAD67 mRNA coincides with the sprouting of unaffected afferent fibers and of 5HT axons, one can hypothesize that GAD67 participates in the structural plasticity occurring in reaction to the capsaicin-induced partial deafferentation.	Capsaicin	227-236	glutamate decarboxylase 1	Rattus norvegicus	150-155
9764438-9	1998	TTX attenuates release of CGRP caused by low concentrations of capsaicin, indicating that an axon reflex mechanism in the peripheral endings of C-fibre afferents can augment local outflow of CGRP.	Capsaicin	63-72	calcitonin related polypeptide alpha	Homo sapiens	26-30
9764438-9	1998	TTX attenuates release of CGRP caused by low concentrations of capsaicin, indicating that an axon reflex mechanism in the peripheral endings of C-fibre afferents can augment local outflow of CGRP.	Capsaicin	63-72	calcitonin related polypeptide alpha	Homo sapiens	191-195
9764438-11	1998	Outflow of CGRP evoked by low pH and capsaicin have common features, such as sensitivity to RR and CPZ.	Capsaicin	37-46	calcitonin related polypeptide alpha	Homo sapiens	11-15
9764438-19	1998	Capsaicin pretreatment resulted in lower myocardial levels of CGRP, and ischaemic myocardium had lower content of CGRP than non-ischaemic areas.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	62-66
9764438-20	1998	Capsaicin-treated animals had larger myocardial infarctions, possibly due to depletion of CGRP.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	90-94
9764438-25	1998	Based on the present findings it may therefore be suggested that local cardiac CGRP-release from capsaicin-sensitive C-fibre afferents during myocardial ischaemia functions as an endogenous physiological protective response.	Capsaicin	97-106	calcitonin related polypeptide alpha	Homo sapiens	79-83
10025074-3	1998	CGRP is the main mediator of the capsaicin-induced flare reaction in the mammalian skin (including humans).	Capsaicin	33-42	calcitonin related polypeptide alpha	Homo sapiens	0-4
9435200-5	1998	The NK3 receptor antagonist had similar effects on the relaxant responses elicited by capsaicin and substance P, but it had no effect on relaxations of the trachealis elicited by electrical field stimulation of the postganglionic nerves that innervate the trachealis or by stimulation of the preganglionic parasympathetic vagal nerves that innervate the trachea.	Capsaicin	86-95	neuromedin-K receptor	Cavia porcellus	4-16
9583573-3	1998	Capsaicin (100 mg/kg subcutaneous (s.c.), 7 days prior to the experiment) which does not block bladder reflexes but does desensitize C-fiber afferents, reduced (89%) the number of Fos-positive cells in the lumbosacral spinal cord induced by acetic acid-induced irritation of the LUT.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	180-183
9461043-16	1997	Our results suggest that CAP induces apoptotic cell death in human gastric cancer cells (SNU-1) in vitro which may be possibly mediated by the overexpression of p53 and/or c-myc genes.	Capsaicin	25-28	tumor protein p53	Homo sapiens	161-164
9461043-16	1997	Our results suggest that CAP induces apoptotic cell death in human gastric cancer cells (SNU-1) in vitro which may be possibly mediated by the overexpression of p53 and/or c-myc genes.	Capsaicin	25-28	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	172-177
9435579-8	1997	PCNA labeling increased opposite to the injury site in both control and capsaicin animals over the first 72 h. We conclude that neuropeptide depletion significantly attenuates both epithelial cell proliferation and repair in the first 72 h after mechanical injury to the trachea.	Capsaicin	72-81	proliferating cell nuclear antigen	Cavia porcellus	0-4
9548509-7	1997	Capsaicin, a vanillyl fatty acid amide (ingredient of hot pepper), released substance P from both human monocytes and macrophages.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	76-87
9460541-7	1997	In the arthritic rats, capsaicin pretreatment significantly lowered the SP-LI and CGRP-LI in the trigeminal ganglia and TMJ, but not the NPY-LI.	Capsaicin	23-32	calcitonin-related polypeptide alpha	Rattus norvegicus	82-86
9389293-12	1997	Albumin and lysozyme levels were both significantly increased 30 minutes after 10 microg and 100 microg of capsaicin (p = 0.005 for both).	Capsaicin	107-116	lysozyme	Homo sapiens	12-20
9475237-5	1997	The addition of a low dose of capsaicin to liquid or food, which stimulates the release of SP, may help prevent aspiration pneumonia.	Capsaicin	30-39	tachykinin precursor 1	Homo sapiens	91-93
9503389-10	1997	administration of sendide was found to produce the antinociceptive effect through the blockage of NK-1 receptors in the mouse formalin and capsaicin tests.	Capsaicin	139-148	tachykinin 1	Mus musculus	98-102
9525296-7	1997	SP and CGRP were detectable in basal lavages (1.37+/-0.12 ng/mL and 2.17+/-0.21 ng/mL, respectively) and the concentration of SP fell by 43% following treatment with capsaicin.	Capsaicin	166-175	calcitonin-related polypeptide alpha	Rattus norvegicus	7-11
9415506-4	1997	Calcitonin gene-related peptide (CGRP), as one of several neuropeptides known to be involved in neurogenic inflammation, was chosen to study capsaicin-induced effects on peripheral neurosecretion.	Capsaicin	141-150	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
9415506-5	1997	The corial surface of the hairy skin of a rat hindlimb was superfused in vitro, and the basal and capsaicin-evoked peripheral release of immunoreactive CGRP (iCGRP) was measured using a radioimmunoassay.	Capsaicin	98-107	calcitonin-related polypeptide alpha	Rattus norvegicus	152-156
9415506-9	1997	Superfusion of the skin with 100 microM capsaicin following a conditioning stimulation with capsaicin at concentrations ranging from 0.3 to 100 microM led to an acute, dose-dependent desensitization of the CGRP response.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	206-210
9415506-9	1997	Superfusion of the skin with 100 microM capsaicin following a conditioning stimulation with capsaicin at concentrations ranging from 0.3 to 100 microM led to an acute, dose-dependent desensitization of the CGRP response.	Capsaicin	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	206-210
9487344-0	1997	Effects of inhaled histamine, methacholine and capsaicin on sputum levels of alpha 2-macroglobulin.	Capsaicin	47-56	alpha-2-macroglobulin	Homo sapiens	77-98
9487344-12	1997	In contrast, capsaicin evoked no exudation (sputum levels of alpha 2-macroglobulin 1.21 (0.28) micrograms/ml (95% CI 0.59 to 1.83)) and methacholine produced a minor increase in sputum levels of alpha 2-macroglobulin (2.90 (0.92) micrograms/ml (95% CI 0.90 to 4.89)).	Capsaicin	13-22	alpha-2-macroglobulin	Homo sapiens	195-216
9372226-0	1997	Intraintestinal capsaicin transiently reduces CGRP-like immunoreactivity in rat submucosal plexus.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	46-50
9406958-0	1997	Capsaicin-induced sensitization of primate spinothalamic tract cells is prevented by a protein kinase C inhibitor.	Capsaicin	0-9	proline rich transmembrane protein 2	Homo sapiens	87-103
9406958-2	1997	This study tested the hypothesis that induction of central sensitization in the dorsal horn by an intradermal capsaicin injection involves activation of PKC.	Capsaicin	110-119	proline rich transmembrane protein 2	Homo sapiens	153-156
12799806-6	1997	Capsaicin acts by depleting stores of substance P and other neurotransmitters, resulting in a blockade of a specific group of sensory afferents.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	38-49
9372226-2	1997	This desensitizing action of capsaicin may be due to an action on CGRP-containing nerve terminals, which are postulated to serve a sensory function in the enteric plexuses.	Capsaicin	29-38	calcitonin-related polypeptide alpha	Rattus norvegicus	66-70
9372226-3	1997	To determine whether intraintestinal capsaicin treatment alters CGRP-like immunoreactivity (CGRP-li) in the enteric plexuses, we performed immunohistochemical analyses of the small intestinal submucosal and myenteric plexuses of rats at various times after intestinal infusion of capsaicin (5 mg) or its vehicle.	Capsaicin	37-46	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
9372226-3	1997	To determine whether intraintestinal capsaicin treatment alters CGRP-like immunoreactivity (CGRP-li) in the enteric plexuses, we performed immunohistochemical analyses of the small intestinal submucosal and myenteric plexuses of rats at various times after intestinal infusion of capsaicin (5 mg) or its vehicle.	Capsaicin	37-46	calcitonin-related polypeptide alpha	Rattus norvegicus	92-96
9372226-4	1997	Intestinal capsaicin treatment, but not vehicle treatment, reduced CGRP-li, but not substance-P-like immunoreactivity (SP-li), in nerve fibers of the submucosal plexus.	Capsaicin	11-20	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
9372226-7	1997	Reduction of CGRP-li in the submucosal fibers also was pronounced 24 h after intraintestinal capsaicin treatment.	Capsaicin	93-102	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
9372226-8	1997	By 48 h after intestinal capsaicin infusion, CGRP-li was not distinguishable from vehicle-treated animals.	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	45-49
9372226-10	1997	These results indicate that intestinal capsaicin selectively induces transient reduction of CGRP-li in nerve fibers of the submucosal plexus.	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	92-96
9372226-11	1997	The chronology of depletion and reappearance of CGRP-li is congruent with previously reported, transient impairment of sensory function observed following intestinal capsaicin infusion.	Capsaicin	166-175	calcitonin-related polypeptide alpha	Rattus norvegicus	48-52
9372230-0	1997	Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat.	Capsaicin	170-179	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	55-60
9372230-0	1997	Peripheral administration of cholecystokinin activates c-fos expression in the locus coeruleus/subcoeruleus nucleus, dorsal vagal complex and paraventricular nucleus via capsaicin-sensitive vagal afferents and CCK-A receptors in the rat.	Capsaicin	170-179	cholecystokinin	Rattus norvegicus	210-213
9372230-9	1997	Perivagal capsaicin pretreatment diminished the CCK-induced increase in the number of c-Fos-LI-positive cells in the LC/SC by 65%.	Capsaicin	10-19	cholecystokinin	Rattus norvegicus	48-51
9372230-9	1997	Perivagal capsaicin pretreatment diminished the CCK-induced increase in the number of c-Fos-LI-positive cells in the LC/SC by 65%.	Capsaicin	10-19	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	86-91
9372230-12	1997	Capsaicin diminished the CCK-induced increase in c-Fos-LI-positive cells in the PVN by 64%, in the NTS by 60%, but in the AP only by 25%.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	25-28
9372230-12	1997	Capsaicin diminished the CCK-induced increase in c-Fos-LI-positive cells in the PVN by 64%, in the NTS by 60%, but in the AP only by 25%.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	49-54
9274806-10	1997	In contracted intrapulmonary bronchi that had been treated with compound 48/80, substance P and capsaicin caused relaxation responses that were inhibited markedly or were nearly abolished by the NK1 receptor antagonist, RP67580, by meclofenamate, and by denuding the epithelium.	Capsaicin	96-105	tachykinin receptor 1	Rattus norvegicus	195-207
9375967-22	1997	These results suggest that CGRP, which is released from peripheral endings of capsaicin-sensitive sensory nerves, partly mediates the hyperaemia evoked by skeletal muscle contraction of the rat hindlimb.	Capsaicin	78-87	calcitonin-related polypeptide alpha	Rattus norvegicus	27-31
9375968-20	1997	These results suggest that CO2 liberated from exercising skeletal muscle activates capsaicin-sensitive perivascular sensory nerves locally, which results in the release of CGRP from their peripheral endings, and then the released peptide causes local vasodilatation.	Capsaicin	83-92	calcitonin-related polypeptide alpha	Rattus norvegicus	172-176
9387036-1	1997	CONCLUSION: Stimulation of pancreatic sensory nerves by capsaicin produced secretory effects probably caused, at least in part, by the release of CGRP.	Capsaicin	56-65	calcitonin-related polypeptide alpha	Rattus norvegicus	146-150
9321877-1	1997	We tested the hypothesis that stimulation of synthesis and secretion of intestinal apolipoprotein A-IV (apo A-IV) by intestinally infused lipid is mediated by capsaicin-sensitive afferent signals.	Capsaicin	159-168	apolipoprotein A4	Rattus norvegicus	83-102
9294232-8	1997	Leptin-CCK action was blocked by systemic capsaicin at a dose inducing functional ablation of sensory afferent fibers and by devazepide, a CCK-A receptor antagonist but not by the CCK-B receptor antagonist, L-365,260.	Capsaicin	42-51	leptin	Mus musculus	0-6
9294232-8	1997	Leptin-CCK action was blocked by systemic capsaicin at a dose inducing functional ablation of sensory afferent fibers and by devazepide, a CCK-A receptor antagonist but not by the CCK-B receptor antagonist, L-365,260.	Capsaicin	42-51	cholecystokinin	Mus musculus	7-10
9294232-12	1997	These results indicate the existence of a functional synergistic interaction between leptin and CCK leading to early suppression of food intake which involves CCK-A receptors and capsaicin-sensitive afferent fibers.	Capsaicin	179-188	leptin	Mus musculus	85-91
9294232-12	1997	These results indicate the existence of a functional synergistic interaction between leptin and CCK leading to early suppression of food intake which involves CCK-A receptors and capsaicin-sensitive afferent fibers.	Capsaicin	179-188	cholecystokinin	Mus musculus	96-99
9316472-7	1997	Acute vagotomy in anesthetized rats and perivagal application of capsaicin in conscious rats abolished pancreatic responses to CCK-JMV-180 at 22 and 44 micrograms.kg-1.h-1.	Capsaicin	65-74	cholecystokinin	Rattus norvegicus	127-130
9316472-11	1997	In separate studies, perivagal application of 1% capsaicin inhibited 95% and 90% of the pancreatic responses to casein and casein combined with intravenous CCK-JMV-180, respectively.	Capsaicin	49-58	cholecystokinin	Rattus norvegicus	156-159
9321877-1	1997	We tested the hypothesis that stimulation of synthesis and secretion of intestinal apolipoprotein A-IV (apo A-IV) by intestinally infused lipid is mediated by capsaicin-sensitive afferent signals.	Capsaicin	159-168	apolipoprotein A4	Rattus norvegicus	104-112
9321877-4	1997	In separate studies the effect of capsaicin treatment on ileal lipid-elicited stimulation of intestinal mucosal apo A-IV synthesis was also examined.	Capsaicin	34-43	apolipoprotein A4	Rattus norvegicus	112-120
9303573-10	1997	Capsaicin-treatment markedly decreased cardiac NO content, CGRP release, and CGRP-immunoreactivity.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	59-63
9284361-6	1997	spinal transection, unilateral dorsal rhizotomy (L4-S2), neonatal capsaicin treatment or direct intrathecal opioid antagonist injection, induced expression of the Fos protein.	Capsaicin	66-75	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	163-166
9273177-4	1997	Among the substances which act as antagonists, particular attention should be paid to capsaicin, which has therapeutic potential for three types of indication: peripheral neurologic pain, affections with a neurogenic inflammatory component and pruriginous dermatosis; peptide T with therapeutic potential for psoriasis; and spantide, which might prove useful in dermatoses related to substance P.	Capsaicin	86-95	tachykinin precursor 1	Homo sapiens	384-395
9371206-8	1997	The CRS outcome measure used was the concentration of capsaicin required to stimulate two (Cth) and five coughs (C5).	Capsaicin	54-63	V-set and immunoglobulin domain containing 2	Homo sapiens	91-94
9303573-10	1997	Capsaicin-treatment markedly decreased cardiac NO content, CGRP release, and CGRP-immunoreactivity.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	77-81
9303573-13	1997	(iii) Release of NO and CGRP from capsaicin-sensitive nerves may be involved in the mechanism of pacing-induced preconditioning.	Capsaicin	34-43	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
9303574-5	1997	Acute application of capsaicin (50 mg/kg) increased the plasma concentration of CGRP-like immunoreactivity (CGRP-LI) concomitantly with a reversal of the inhibition by LPC of endothelium-dependent ACh-induced relaxation in the isolated rat aorta.	Capsaicin	21-30	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
9303574-5	1997	Acute application of capsaicin (50 mg/kg) increased the plasma concentration of CGRP-like immunoreactivity (CGRP-LI) concomitantly with a reversal of the inhibition by LPC of endothelium-dependent ACh-induced relaxation in the isolated rat aorta.	Capsaicin	21-30	calcitonin-related polypeptide alpha	Rattus norvegicus	108-112
9303574-7	1997	The results demonstrate that systemic capsaicin treatment, which evokes the release of CGRP from sensory nerves, protects the endothelial cell.	Capsaicin	38-47	calcitonin-related polypeptide alpha	Rattus norvegicus	87-91
9388756-0	1997	Capsaicin stimulates release of substance P from dorsal root ganglion neurons via two distinct mechanisms.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	32-43
9286623-3	1997	Our data suggest that the gastroprotective activity of amylin in some experimental models of gastric ulcers involves capsaicin-sensitive fibers and CGRP receptors.	Capsaicin	117-126	islet amyloid polypeptide	Homo sapiens	55-61
9219953-4	1997	Topical capsaicin applied to the vagal nerve trunk abolished the accumulation of sites binding both [125I]Bolton Hunter-labelled cholecystokinin-8 and heptadecapeptide gastrin indicating that both cholecystokininA and gastrin-cholecystokininB receptor populations were present on afferent fibres.	Capsaicin	8-17	gastrin	Rattus norvegicus	168-175
9291295-3	1997	OBJECTIVES: To determine the effects of intradermally injected and topically applied capsaicin on the release of histamine and substance P and skin responses in intact human skin in vivo.	Capsaicin	85-94	tachykinin precursor 1	Homo sapiens	127-138
9291295-10	1997	Substance P-like immunoreactivity (SP-LI) was below the 1.8 pM detection limit following insertion of 20 kDa dialysis fibre and after intradermal injection of capsaicin 3 microM.	Capsaicin	159-168	tachykinin precursor 1	Homo sapiens	0-11
9219953-4	1997	Topical capsaicin applied to the vagal nerve trunk abolished the accumulation of sites binding both [125I]Bolton Hunter-labelled cholecystokinin-8 and heptadecapeptide gastrin indicating that both cholecystokininA and gastrin-cholecystokininB receptor populations were present on afferent fibres.	Capsaicin	8-17	gastrin	Rattus norvegicus	218-225
9259450-4	1997	Capsaicin treatment of naive rats significantly reduced substance P in all tissues and NGF levels in the sciatic nerve.	Capsaicin	0-9	nerve growth factor	Rattus norvegicus	87-90
9272723-0	1997	MEN 11,420, a peptide tachykinin NK2 receptor antagonist, reduces motor responses induced by the intravesical administration of capsaicin in vivo.	Capsaicin	128-137	tachykinin receptor 2	Homo sapiens	33-45
9308027-4	1997	Co-injection of NK1, (FK 888, GR 82334), NK2 (SR 48968) or NK3 (SR 142801) receptor antagonists with capsaicin dose-dependently attenuated capsaicin-induced licking.	Capsaicin	101-110	tachykinin 1	Mus musculus	16-19
9308027-4	1997	Co-injection of NK1, (FK 888, GR 82334), NK2 (SR 48968) or NK3 (SR 142801) receptor antagonists with capsaicin dose-dependently attenuated capsaicin-induced licking.	Capsaicin	139-148	tachykinin 1	Mus musculus	16-19
9308027-4	1997	Co-injection of NK1, (FK 888, GR 82334), NK2 (SR 48968) or NK3 (SR 142801) receptor antagonists with capsaicin dose-dependently attenuated capsaicin-induced licking.	Capsaicin	139-148	hepatocyte growth factor	Mus musculus	41-44
9308027-10	1997	injection of NK1, NK2 or NK3 receptor antagonists (15-500 pmol/site), all produced significant and dose-dependent inhibition of both phases of the formalin and capsaicin tests.	Capsaicin	160-169	tachykinin 1	Mus musculus	13-16
9308027-10	1997	injection of NK1, NK2 or NK3 receptor antagonists (15-500 pmol/site), all produced significant and dose-dependent inhibition of both phases of the formalin and capsaicin tests.	Capsaicin	160-169	hepatocyte growth factor	Mus musculus	18-21
9308027-10	1997	injection of NK1, NK2 or NK3 receptor antagonists (15-500 pmol/site), all produced significant and dose-dependent inhibition of both phases of the formalin and capsaicin tests.	Capsaicin	160-169	tachykinin receptor 3	Mus musculus	25-37
9259450-5	1997	In contrast, gamma-PPT mRNA and trkA mRNA expression in DRG were significantly increased after capsaicin treatment.	Capsaicin	95-104	tachykinin, precursor 1	Rattus norvegicus	19-22
9259450-5	1997	In contrast, gamma-PPT mRNA and trkA mRNA expression in DRG were significantly increased after capsaicin treatment.	Capsaicin	95-104	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	32-36
9252506-7	1997	Gastric hyperemia is mediated by CGRP contained in capsaicin-sensitive afferent fibers, whereas acid secretion is under the inhibitory influence of prostaglandins and CGRP.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
9222561-5	1997	Capsaicin, resiniferatoxin (RTX) and olvanil each evoked a concentration-dependent increase in CGRP release with pEC50 values of 6.55 +/- 0.07, 7.90 +/- 0.24 and 6.19 +/- 0.15 respectively.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	95-99
9288221-2	1997	Pre-treatment with exogenous NPY markedly reduced nasal airway obstruction and rhinorrhea induced by the irritant capsaicin in control subjects.	Capsaicin	114-123	neuropeptide Y	Homo sapiens	29-32
9288221-9	1997	Variations of plasma NPY concentrations over time correlated better with post-exercise nasal vasoconstriction and hyporeactivity to capsaicin than NA.	Capsaicin	132-141	neuropeptide Y	Homo sapiens	21-24
9378245-0	1997	Capsazocaine: a capsaicin-sensitive functional antagonist displays an argument on sensory capsaicin receptor.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	90-108
9201090-2	1997	Chemical deafferentation by capsaicin abolished the density of CGRP-immunoreactive (IR) fibers, not Sub.P-IR fibers.	Capsaicin	28-37	calcitonin-related polypeptide alpha	Rattus norvegicus	63-67
9246052-6	1997	Capsaicin caused water secretion and significant release of myeloperoxidase, interleukin-1, and prostaglandin-E2, effects that were blocked by Iidocaine.	Capsaicin	0-9	myeloperoxidase	Cavia porcellus	60-75
9207766-7	1997	When the three concentrations of capsaicin solution were applied in turn, the electrical threshold and latency of A beta and fast A delta fibers did not change, whereas those of slow A delta and C fibers gradually increased.	Capsaicin	33-42	amyloid beta precursor protein	Homo sapiens	114-120
9207766-8	1997	In 0/11 A beta, 0/26 fast A delta, 13/25 slow A delta, and 18/20 C fibers, the conduction was blocked reversibly or irreversibly following the application of 10 muM of capsaicin.	Capsaicin	168-177	amyloid beta precursor protein	Homo sapiens	8-14
9207766-11	1997	A single low concentration of capsaicin (100 nM) activated only some slow-conducting fibers (0/4 A beta, 0/4 FA delta, 3/6 SA delta and 4/6 C).	Capsaicin	30-39	amyloid beta precursor protein	Homo sapiens	97-103
9231870-7	1997	N-terminal metabolic fragments of SP that accumulate after capsaicin-induced SP release and are involved in the antinociceptive effect of capsaicin, were also tested.	Capsaicin	59-68	tachykinin 1	Mus musculus	34-36
9231870-7	1997	N-terminal metabolic fragments of SP that accumulate after capsaicin-induced SP release and are involved in the antinociceptive effect of capsaicin, were also tested.	Capsaicin	59-68	tachykinin 1	Mus musculus	77-79
9231870-7	1997	N-terminal metabolic fragments of SP that accumulate after capsaicin-induced SP release and are involved in the antinociceptive effect of capsaicin, were also tested.	Capsaicin	138-147	tachykinin 1	Mus musculus	34-36
9231870-10	1997	In contrast, capsaicin-evoked SP release decreased significantly in tissue from mice pretreated with capsaicin or SP(1-7) 48 h prior to testing.	Capsaicin	13-22	tachykinin 1	Mus musculus	30-32
9231870-10	1997	In contrast, capsaicin-evoked SP release decreased significantly in tissue from mice pretreated with capsaicin or SP(1-7) 48 h prior to testing.	Capsaicin	13-22	tachykinin 1	Mus musculus	114-116
9231870-10	1997	In contrast, capsaicin-evoked SP release decreased significantly in tissue from mice pretreated with capsaicin or SP(1-7) 48 h prior to testing.	Capsaicin	101-110	tachykinin 1	Mus musculus	30-32
9231870-11	1997	D-Substance P(1-7), which prevents antinociception, blocked capsaicin- and SP(1-7)-induced decreases in SP release, indicating that these effects are mediated by SP N-terminal activity.	Capsaicin	60-69	tachykinin 1	Mus musculus	2-13
9231870-11	1997	D-Substance P(1-7), which prevents antinociception, blocked capsaicin- and SP(1-7)-induced decreases in SP release, indicating that these effects are mediated by SP N-terminal activity.	Capsaicin	60-69	tachykinin 1	Mus musculus	104-106
9231870-11	1997	D-Substance P(1-7), which prevents antinociception, blocked capsaicin- and SP(1-7)-induced decreases in SP release, indicating that these effects are mediated by SP N-terminal activity.	Capsaicin	60-69	tachykinin 1	Mus musculus	104-106
9196099-4	1997	Measures of CRS were the concentration of capsaicin required to stimulate > or = 2 coughs (Cth) and > or = 5 coughs (C5).	Capsaicin	42-51	V-set and immunoglobulin domain containing 2	Homo sapiens	94-97
9231870-0	1997	Inhibition of substance P release from spinal cord tissue after pretreatment with capsaicin does not mediate the antinociceptive effect of capsaicin in adult mice.	Capsaicin	82-91	tachykinin 1	Mus musculus	14-25
9231870-2	1997	Capsaicin, which produces an initial hyperalgesic response followed by persistent antinociception, also elicits release of SP from primary afferent fibers.	Capsaicin	0-9	tachykinin 1	Mus musculus	123-125
9231870-3	1997	Capsaicin pretreatment decreases the content and release of SP from primary afferent fibers.	Capsaicin	0-9	tachykinin 1	Mus musculus	60-62
9231870-4	1997	This effect on SP has been hypothesized to mediate the antinociceptive effect of capsaicin.	Capsaicin	81-90	tachykinin 1	Mus musculus	15-17
9237551-4	1997	Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2(+)-dependent and originated from capsaicin-sensitive nerve terminals.	Capsaicin	129-138	tachykinin precursor 1	Homo sapiens	24-35
9237551-4	1997	Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2(+)-dependent and originated from capsaicin-sensitive nerve terminals.	Capsaicin	129-138	tachykinin precursor 1	Homo sapiens	52-63
9221943-5	1997	Furthermore, the antinociception produced by SP was present in mice pre-treated with systemic administration of capsaicin during the neonatal period.	Capsaicin	112-121	tachykinin 1	Mus musculus	45-47
9201090-8	1997	Furthermore, the present results support that CGRP-IR fibers, not Sub.P-IR fibers, in the rat stomach are capsaicin-sensitive.	Capsaicin	106-115	calcitonin-related polypeptide alpha	Rattus norvegicus	46-50
9163580-5	1997	Stimulation of gastrin release by 10 ml distention in sham-operated control rats was reversed to an inhibition after truncal vagotomy (26+/-7 vs. -11+/-4 pg/ml; P<0.05) and capsaicin-treatment (37+/-18 vs. -34+/-11 pg/ml; P<0.05).	Capsaicin	176-185	gastrin	Rattus norvegicus	15-22
9151757-7	1997	Over the range of 40 to 34 degrees C, the Q10 values for evoked release for CGRP were 11.3 (potassium) and 39.7 (capsaicin) and for glutamate, 5.	Capsaicin	113-122	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
9179878-3	1997	On the other hand, the injection of capsaicin produced protracted increases in adrenal nerve activity and catecholamine secretion both in CNS-intact animals and in animals acutely spinalized at the Cl-2 level.	Capsaicin	36-45	calpain 8	Rattus norvegicus	198-202
9142909-5	1997	Capsaicin- and bradykinin-stimulated extravasation was attenuated by an NK1-receptor antagonist and is thus mediated by release of tachykinins and activation of the NK1 receptor.	Capsaicin	0-9	tachykinin receptor 1	Mus musculus	72-84
9142909-5	1997	Capsaicin- and bradykinin-stimulated extravasation was attenuated by an NK1-receptor antagonist and is thus mediated by release of tachykinins and activation of the NK1 receptor.	Capsaicin	0-9	tachykinin receptor 1	Mus musculus	165-177
9142909-6	1997	We conclude that 1) substance P stimulates extravasation in the gastrointestinal tract and pancreas of mice by interacting with the NK1 receptors, and 2) capsaicin and bradykinin induce plasma extravasation by stimulating tachykinin release from sensory nerves.	Capsaicin	154-163	killer cell lectin-like receptor, subfamily A, member 3	Mus musculus	132-152
9103474-14	1997	These results demonstrate that capsaicin, a selective C-fiber activator, relaxes small veins in an endothelium-dependent but CGRP- and substance P-independent manner, and they demonstrate that the venous side of the microcirculation responds directly to sensory stimulation.	Capsaicin	31-40	calcitonin-related polypeptide alpha	Rattus norvegicus	125-129
9264053-3	1997	Systemic administration of CGRP (100 micrograms kg-1 s.c.) produced a significant decrease in lesion index of WIS-ulcers and this protection was inhibited by functional ablation of afferent neurons induced by capsaicin pretreatment (100 mg kg-1 s.c. in two days, a week before the experiments).	Capsaicin	209-218	calcitonin-related polypeptide alpha	Rattus norvegicus	27-31
9178350-0	1997	Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo.	Capsaicin	0-9	adenylate cyclase activating polypeptide 1	Rattus norvegicus	28-74
9178350-0	1997	Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo.	Capsaicin	0-9	adenylate cyclase activating polypeptide 1	Rattus norvegicus	76-81
9250575-8	1997	Neonatal pretreatment with capsaicin reduced abdominal contractions produced by AA (0.6%) and CGRP (20 microg/kg) with 64.6% and 45.6%, respectively.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	94-98
9163575-5	1997	Substance P recovered by 5 days (diclofenac in hyaluronan, capsaicin) and 24 h (diclofenac).	Capsaicin	59-68	tachykinin 1	Mus musculus	0-11
9155831-9	1997	Long-term topical capsaicin administration inhibited histamine release and wheal reactions by PAF but not by codeine.	Capsaicin	18-27	PCNA clamp associated factor	Homo sapiens	94-97
9163536-6	1997	Also, in capsaicin-treated rats, we counted 59% fewer Fos-labeled neurons in the spinal cord.	Capsaicin	9-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	54-57
9092738-3	1997	Capsaicin can deplete substance P from the peripheral neurons and is known to be effective in the treatment of pain and itching.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	22-33
9070755-5	1997	After nematode infection or neonatal treatment with capsaicin, a large increase in the number of rat mast cell protease II-immunoreactive mast cells was found within dura mater segments (+1478% and +596%, respectively), without concomitant changes of rat mast cell protease I- or rat mast cell protease I/II-immunoreactive mast cells.	Capsaicin	52-61	mast cell protease 2	Rattus norvegicus	101-122
9070755-6	1997	Under both these conditions, the increase in mast cell number was accompanied by a significant increase in rat mast cell protease II level within tissue extracts (+281% after nematode infection and +36% after capsaicin treatment).	Capsaicin	209-218	mast cell protease 2	Rattus norvegicus	111-132
9178350-0	1997	Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	87-118
9178350-0	1997	Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP) and calcitonin gene-related peptide (CGRP) from rat spinal cord in vivo.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	120-124
9178350-1	1997	Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP)-like immunoreactivity (LI) from rat spinal cord was examined in vivo.	Capsaicin	0-9	adenylate cyclase activating polypeptide 1	Rattus norvegicus	28-74
9178350-1	1997	Capsaicin-evoked release of pituitary adenylate cyclase activating peptide (PACAP)-like immunoreactivity (LI) from rat spinal cord was examined in vivo.	Capsaicin	0-9	adenylate cyclase activating polypeptide 1	Rattus norvegicus	76-81
9178350-6	1997	The addition of capsaicin (10 microM) to the perfusate elevated the concentrations of PACAP-27-LI in the artificial cerebrospinal fluid by 177%, PACAP-38-LI by 93% and CGRP-LI by 692%.	Capsaicin	16-25	adenylate cyclase activating polypeptide 1	Rattus norvegicus	86-91
9178350-6	1997	The addition of capsaicin (10 microM) to the perfusate elevated the concentrations of PACAP-27-LI in the artificial cerebrospinal fluid by 177%, PACAP-38-LI by 93% and CGRP-LI by 692%.	Capsaicin	16-25	adenylate cyclase activating polypeptide 1	Rattus norvegicus	145-150
9178350-6	1997	The addition of capsaicin (10 microM) to the perfusate elevated the concentrations of PACAP-27-LI in the artificial cerebrospinal fluid by 177%, PACAP-38-LI by 93% and CGRP-LI by 692%.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	168-172
9049141-3	1997	Postprandial PYY release was suppressed or strongly decreased by caecocolonectomy, truncal vagotomy, tetrodotoxin, hexamethonium, sensory denervation by perivagal capsaicin, and by the NO-synthase inhibitor L-N-arginine methyl ester, while atropine, adrenergic blockers, antagonists of type-A or type-B cholecystokinin (CCK) receptors or bombesin receptors had no effect.	Capsaicin	163-172	peptide YY	Rattus norvegicus	13-16
9111833-0	1997	The effect of topical capsaicin on substance P immunoreactivity: a clinical trial and immunohistochemical analysis.	Capsaicin	22-31	tachykinin precursor 1	Homo sapiens	35-46
9138695-11	1997	Treatment with LIF (0.5 ng ml-1) for 3 and 6 h significantly increased contractile responses to capsaicin by 42% and 43%, respectively, compared to time controls, whereas higher concentrations of LIF (5 and 50 ng ml-1) enhanced capsaicin-induced contractions only after 6 h. After 24 h, responses to capsaicin were not significantly different from 0 h control.	Capsaicin	96-105	leukemia inhibitory factor	Cavia porcellus	15-18
9138695-11	1997	Treatment with LIF (0.5 ng ml-1) for 3 and 6 h significantly increased contractile responses to capsaicin by 42% and 43%, respectively, compared to time controls, whereas higher concentrations of LIF (5 and 50 ng ml-1) enhanced capsaicin-induced contractions only after 6 h. After 24 h, responses to capsaicin were not significantly different from 0 h control.	Capsaicin	228-237	leukemia inhibitory factor	Cavia porcellus	15-18
9138695-11	1997	Treatment with LIF (0.5 ng ml-1) for 3 and 6 h significantly increased contractile responses to capsaicin by 42% and 43%, respectively, compared to time controls, whereas higher concentrations of LIF (5 and 50 ng ml-1) enhanced capsaicin-induced contractions only after 6 h. After 24 h, responses to capsaicin were not significantly different from 0 h control.	Capsaicin	228-237	leukemia inhibitory factor	Cavia porcellus	15-18
9138695-12	1997	Contractile responses to capsaicin following exposure to LIF at any concentration for 24 h were not significantly different from relative time control values.	Capsaicin	25-34	leukemia inhibitory factor	Cavia porcellus	57-60
9138695-17	1997	In the acute setting LIF augments the capsaicin-induced release of endogenous tachykinins, whilst in the longer term (> 24 h), LIF increases airway smooth muscle responses to tachykinins via an NK2 receptor selective mechanism.	Capsaicin	38-47	leukemia inhibitory factor	Cavia porcellus	21-24
9138695-17	1997	In the acute setting LIF augments the capsaicin-induced release of endogenous tachykinins, whilst in the longer term (> 24 h), LIF increases airway smooth muscle responses to tachykinins via an NK2 receptor selective mechanism.	Capsaicin	38-47	substance-K receptor	Cavia porcellus	197-209
9061096-6	1997	Intense activation of spinal nociceptive pathways by intrathecal capsaicin injections also led to beta-endorphin release.	Capsaicin	65-74	proopiomelanocortin	Homo sapiens	98-112
9067440-0	1997	Corticotropin-releasing factor and systemic capsaicin-sensitive afferents are involved in abdominal surgery-induced Fos expression in the paraventricular nucleus of the hypothalamus.	Capsaicin	44-53	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	116-119
9067440-7	1997	Capsaicin (125 mg/kg s.c., 2 weeks before) or alpha-helical CRF9-41 (50 microg i.c.v., before surgery) reduced the number of Fos-positive cells by 50% in the PVN while not modifying the number of Fos-labelled cells in the other nuclei.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	125-128
9067440-7	1997	Capsaicin (125 mg/kg s.c., 2 weeks before) or alpha-helical CRF9-41 (50 microg i.c.v., before surgery) reduced the number of Fos-positive cells by 50% in the PVN while not modifying the number of Fos-labelled cells in the other nuclei.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	196-199
8994052-0	1997	Tumor necrosis factor enhances the capsaicin sensitivity of rat sensory neurons.	Capsaicin	35-44	tumor necrosis factor-like	Rattus norvegicus	0-21
8994052-1	1997	The capacity of the proinflammatory cytokines, tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta), to modulate the sensitivity of isolated sensory neurons grown in culture to the excitatory chemical agent capsaicin was examined.	Capsaicin	229-238	tumor necrosis factor	Rattus norvegicus	47-74
8994052-1	1997	The capacity of the proinflammatory cytokines, tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta), to modulate the sensitivity of isolated sensory neurons grown in culture to the excitatory chemical agent capsaicin was examined.	Capsaicin	229-238	interleukin 1 beta	Rattus norvegicus	91-109
8994052-1	1997	The capacity of the proinflammatory cytokines, tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta), to modulate the sensitivity of isolated sensory neurons grown in culture to the excitatory chemical agent capsaicin was examined.	Capsaicin	229-238	interleukin 1 beta	Rattus norvegicus	111-120
8994052-3	1997	A 24 hr pretreatment of the neuronal cultures with TNF alpha (10 or 50 ng/ml), but not IL-1 beta (10 or 50 ng/ml), produced a concentration-dependent increase in the number of cobalt-labeled neurons after exposure to 100 nM capsaicin.	Capsaicin	224-233	tumor necrosis factor	Rattus norvegicus	51-60
8994052-5	1997	Similarly, pretreatment with TNF alpha (10 ng/ml for 4, 12, and 24 hr) produced a greater than twofold increase in the average peak amplitude of the inward current evoked by 100 nM capsaicin.	Capsaicin	181-190	tumor necrosis factor	Rattus norvegicus	29-38
8994052-7	1997	Enhancement of the capsaicin-evoked current also was blocked by the specific cyclo-oxygenase-2 inhibitor SC-236.	Capsaicin	19-28	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	77-94
8994052-8	1997	These results indicate that TNF alpha can enhance the sensitivity of sensory neurons to the excitation produced by capsaicin and that this enhancement likely is mediated by the neuronal production of prostaglandins.	Capsaicin	115-124	tumor necrosis factor	Rattus norvegicus	28-37
9038892-8	1997	Significantly greater levels of Fos were observed in the myenteric plexus of sensitized animals challenged with EA, even after pretreatment with capsaicin (125 mg/kg).	Capsaicin	145-154	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	32-35
9038882-0	1997	Endogenous CCK disrupts the MMC pattern via capsaicin-sensitive vagal afferent fibers in the rat.	Capsaicin	44-53	cholecystokinin	Rattus norvegicus	11-14
9064474-9	1997	These data suggest that, in the pial arteries of SHR, the transient vasodilation to capsaicin and enhanced vasodilation to CGRP are related to the decreased CGRP level in the cerebral microvascular beds, consequently leading to increased sensitivity of the CGRP receptors to CGRP.	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	157-161
9038882-9	1997	In capsaicin-treated rats, the intracerebroventricular or intravenous infusion of L-364,718 inhibited CCK-8 effects.	Capsaicin	3-12	cholecystokinin	Rattus norvegicus	102-105
8996233-13	1997	After exposure to capsaicin (10(-5) M) or H2O2/FeSO4 of the artery ring preparations, the intensity of CGRP-like immunoreactivity of the periarterial nerves was reduced drastically; the relaxation caused by the nerve stimulation was nearly fully inhibited by capsaicin and H2O2/FeSO4 reaction.	Capsaicin	18-27	calcitonin related polypeptide alpha	Homo sapiens	103-107
8996233-13	1997	After exposure to capsaicin (10(-5) M) or H2O2/FeSO4 of the artery ring preparations, the intensity of CGRP-like immunoreactivity of the periarterial nerves was reduced drastically; the relaxation caused by the nerve stimulation was nearly fully inhibited by capsaicin and H2O2/FeSO4 reaction.	Capsaicin	259-268	calcitonin related polypeptide alpha	Homo sapiens	103-107
9064474-9	1997	These data suggest that, in the pial arteries of SHR, the transient vasodilation to capsaicin and enhanced vasodilation to CGRP are related to the decreased CGRP level in the cerebral microvascular beds, consequently leading to increased sensitivity of the CGRP receptors to CGRP.	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	157-161
9064474-9	1997	These data suggest that, in the pial arteries of SHR, the transient vasodilation to capsaicin and enhanced vasodilation to CGRP are related to the decreased CGRP level in the cerebral microvascular beds, consequently leading to increased sensitivity of the CGRP receptors to CGRP.	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	157-161
9128919-10	1997	Although capsaicin treatment altered visceral chemosensory function, corneal and pain sensitivity, vagal-mediated anorexic effects of cholecystokinin, and depleted levels of substance P in the thoracic spinal cord, it was completely ineffective in blocking the decrease in food-motivated behavior induced by IL-1beta (4 microg/rat I.P.	Capsaicin	9-18	interleukin 1 beta	Rattus norvegicus	308-316
9479624-0	1997	Importance of nitric oxide and capsaicin-sensitive afferent nerves in healing of stress lesions induced by epidermal growth factor.	Capsaicin	31-40	epidermal growth factor like 1	Rattus norvegicus	107-130
9479624-9	1997	The acceleration of the healing and accompanying hyperemia induced by EGF at 12 h after WRS were completely reversed in rats pretreated with L-NAME or in those with capsaicin denervation.	Capsaicin	165-174	epidermal growth factor like 1	Rattus norvegicus	70-73
8906816-3	1996	Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a quinone that has been shown to regulate a wide variety of activities that require NF-kappa B activation.	Capsaicin	11-43	nuclear factor kappa B subunit 1	Homo sapiens	132-142
8997245-5	1996	Blockade of NK2 but not NK1 receptors prevented by 65% the protection evoked by topical capsaicin without affecting capsaicin-induced hyperemia.	Capsaicin	88-97	tachykinin receptor 2	Homo sapiens	12-15
8942724-7	1996	However, both systemic capsaicin and indo-methacin enhanced RMCP II release.	Capsaicin	23-32	mast cell protease 2	Rattus norvegicus	60-67
8942724-9	1996	CONCLUSIONS: Central vagal activation by TRH stimulates intestinal mast cell secretion, in part via peripheral muscarinic receptors, and is modulated by PGs and capsaicin-sensitive afferent innervation.	Capsaicin	161-170	thyrotropin releasing hormone	Rattus norvegicus	41-44
8971780-1	1997	While systemic capsaicin in adult rats is known to reduce substance P and somatostatin in primary sensory nerves, it is still unknown if it also affects the production of these peptides at the genetic level.	Capsaicin	15-24	somatostatin	Rattus norvegicus	74-86
8971780-2	1997	Therefore, we examined the effects of systemically administered capsaicin on the expression of the beta-preprotachykinin, gamma-preprotachykinin, somatostatin, calcitonin gene-related peptide, vasoactive intestinal polypeptide, galanin, neuropeptide Y and neurotrophin receptor family (trkA, trkB, trkC) genes in dorsal root ganglion neurons by in situ hybridization in adult rats.	Capsaicin	64-73	somatostatin	Rattus norvegicus	146-158
8971780-7	1997	On the other hand, vasoactive intestinal polypeptide and galanin messenger RNAs, but not neuropeptide Y messenger RNA, began to be expressed in about 10% of dorsal root ganglion neurons after administration of capsaicin, although their messenger RNAs were not detected in the controls.	Capsaicin	210-219	vasoactive intestinal peptide	Rattus norvegicus	19-52
8971780-12	1997	Our results suggest that systemic administration of capsaicin in adult rats depresses the expression of beta/gamma-preprotachykinin, calcitonin gene-related peptide and trkA messenger RNAs, and induces expression of vasoactive intestinal polypeptide and galanin messenger RNAs in sensory neurons, which may be due to the capsaicin-induced degeneration of a subpopulation of sensory afferents.	Capsaicin	52-61	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	169-173
8971780-12	1997	Our results suggest that systemic administration of capsaicin in adult rats depresses the expression of beta/gamma-preprotachykinin, calcitonin gene-related peptide and trkA messenger RNAs, and induces expression of vasoactive intestinal polypeptide and galanin messenger RNAs in sensory neurons, which may be due to the capsaicin-induced degeneration of a subpopulation of sensory afferents.	Capsaicin	52-61	vasoactive intestinal peptide	Rattus norvegicus	216-249
8993476-3	1996	The observation that capsaicin releases both PACAP and CGRP from the iris and ciliary body supports the view that PACAP is present in C fibers in the rabbit eye.	Capsaicin	21-30	LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide	Oryctolagus cuniculus	45-50
8993476-3	1996	The observation that capsaicin releases both PACAP and CGRP from the iris and ciliary body supports the view that PACAP is present in C fibers in the rabbit eye.	Capsaicin	21-30	LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide	Oryctolagus cuniculus	114-119
9134101-3	1996	Capsaicin injections caused a consistent reduction in numbers of CGRP- and substance P-immunoreactive fibres in the pulps and a somewhat smaller reduction in the periodontal tissues.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
8906816-3	1996	Capsaicin (8-methyl-N-vanillyl-6-nonenamide) is a quinone that has been shown to regulate a wide variety of activities that require NF-kappa B activation.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	132-142
8906816-4	1996	In the present study, we examined the effect of capsaicin and its analogue, resiniferatoxin, on the activation of NF-kappa B induced by different agents including TNF.	Capsaicin	48-57	nuclear factor kappa B subunit 1	Homo sapiens	114-124
8906816-4	1996	In the present study, we examined the effect of capsaicin and its analogue, resiniferatoxin, on the activation of NF-kappa B induced by different agents including TNF.	Capsaicin	48-57	tumor necrosis factor	Homo sapiens	163-166
8906816-5	1996	The pretreatment of human myeloid ML-1a cells with capsaicin blocked TNF-mediated activation of NF-kappa B in a dose- and time-dependent manner.	Capsaicin	51-60	tumor necrosis factor	Homo sapiens	69-72
8906816-5	1996	The pretreatment of human myeloid ML-1a cells with capsaicin blocked TNF-mediated activation of NF-kappa B in a dose- and time-dependent manner.	Capsaicin	51-60	nuclear factor kappa B subunit 1	Homo sapiens	96-106
8906816-6	1996	Resiniferatoxin was at least eight times as potent as capsaicin in inhibiting NF-kappa B activation.	Capsaicin	54-63	nuclear factor kappa B subunit 1	Homo sapiens	78-88
8906816-8	1996	Capsaicin also blocked phorbol ester-mediated NF-kappa B activation, but that mediated through okadaic acid was less effective, suggesting there is a difference in the mechanism of activation of NF-kappa B by different agents.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	46-56
8906816-8	1996	Capsaicin also blocked phorbol ester-mediated NF-kappa B activation, but that mediated through okadaic acid was less effective, suggesting there is a difference in the mechanism of activation of NF-kappa B by different agents.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	195-205
8906816-9	1996	Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.	Capsaicin	0-9	NFKB inhibitor alpha	Homo sapiens	61-76
8906816-9	1996	Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.	Capsaicin	0-9	RELA proto-oncogene, NF-kB subunit	Homo sapiens	120-145
8906816-9	1996	Capsaicin treatment of cells also blocked the degradation of I kappa B alpha, and thus the nuclear translocation of the p65 subunit of NF-kappa B, which is essential for NF-kappa B activation.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	135-145
8906816-10	1996	TNF-dependent promoter activity of I kappa B alpha, which contains NF-kappa B binding sites, was also inhibited by capsaicin.	Capsaicin	115-124	tumor necrosis factor	Homo sapiens	0-3
8906816-10	1996	TNF-dependent promoter activity of I kappa B alpha, which contains NF-kappa B binding sites, was also inhibited by capsaicin.	Capsaicin	115-124	NFKB inhibitor alpha	Homo sapiens	35-50
8906816-10	1996	TNF-dependent promoter activity of I kappa B alpha, which contains NF-kappa B binding sites, was also inhibited by capsaicin.	Capsaicin	115-124	nuclear factor kappa B subunit 1	Homo sapiens	67-77
8906816-11	1996	Overall our results indicate that capsaicin and its analogue inhibit NF-kappa B activation, and thus could be used as a potential target for drug development.	Capsaicin	34-43	nuclear factor kappa B subunit 1	Homo sapiens	69-79
8897896-0	1996	Capsaicin-induced release of VIP-like immunoreactivity: modulation by enzyme inhibitors.	Capsaicin	0-9	VIP peptides	Cavia porcellus	29-32
8917685-6	1996	The results obtained were represented in a Dixon plot and showed that capsaicin acts as a competitive and efficient inhibitor of tyrosyl-tRNA synthetase catalyzed reaction (Ki = 41.7 microM).	Capsaicin	70-79	tyrosyl-tRNA synthetase	Mus musculus	129-152
8897896-4	1996	Infusion of capsaicin resulted in a significant increase in VIP-LI in the perfusate (12.32 +/- 4.80 to 33.52 +/- 8.46 fmol/5 min fraction; P < 0.001).	Capsaicin	12-21	VIP peptides	Cavia porcellus	60-63
8897896-7	1996	In addition, recovery of VIP-LI in the superfusate after infusion of capsaicin was significantly greater in the group of lungs that was superfused with Thio + STI compared with STI, Thio, and control groups.	Capsaicin	69-78	VIP peptides	Cavia porcellus	25-28
8960879-4	1996	The 5-HT3 receptor antagonist ondansetron (10 micrograms/kg) abolished the phenylbiguanide- but not the capsaicin-stimulated bradycardia, indicating that phenylbiguanide and capsaicin act via different trigger mechanisms (5-HT3 receptor-dependent and -independent, respectively).	Capsaicin	174-183	5-hydroxytryptamine receptor 3A	Rattus norvegicus	4-18
8957683-0	1996	Capsaicin-induced calcitonin gene-related peptide release from isolated rat stomach measured with a new chemiluminescent enzyme immunoassay.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	18-49
8957683-1	1996	The peripheral capsaicin-sensitive afferent nerve has been reported to play an important role in gastroprotection and to release a calcitonin gene-related peptide (CGRP).	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	131-162
8957683-1	1996	The peripheral capsaicin-sensitive afferent nerve has been reported to play an important role in gastroprotection and to release a calcitonin gene-related peptide (CGRP).	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	164-168
8957683-2	1996	We developed a new chemiluminescent enzyme immunoassay (CLEIA) for CGRP and measured capsaicin-induced CGRP release from the isolated and inverted rat stomach.	Capsaicin	85-94	calcitonin-related polypeptide alpha	Rattus norvegicus	103-107
8957683-4	1996	Capsaicin (1 x 10(-8)-1 x 10(-5) M) stimulated CGRP release in a concentration-dependent manner.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	47-51
8957683-5	1996	In the stomach from rats with defunctionalization of afferent neurons, the levels of the basal and capsaicin-induced CGRP release were below the limit of detection.	Capsaicin	99-108	calcitonin-related polypeptide alpha	Rattus norvegicus	117-121
8957683-6	1996	On the other hand, the capsaicin-induced CGRP release was not blocked by tetrodotoxin treatment.	Capsaicin	23-32	calcitonin-related polypeptide alpha	Rattus norvegicus	41-45
8957683-8	1996	However, the capsaicin-induced CGRP release was not affected by pretreatment with 6-hydroxydopamine, a neurotoxin that causes a complete degeneration of adrenergic nerve terminals.	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	31-35
8957683-10	1996	Our results also confirmed that although the CGRP-containing nerve runs in the sympathetic nerve trunk, the activity of the nerve is not affected by adrenergic nerves, and the capsaicin-induced CGRP release may be attributable to the tetrodotoxin-resistant component.	Capsaicin	176-185	calcitonin-related polypeptide alpha	Rattus norvegicus	45-49
8957683-10	1996	Our results also confirmed that although the CGRP-containing nerve runs in the sympathetic nerve trunk, the activity of the nerve is not affected by adrenergic nerves, and the capsaicin-induced CGRP release may be attributable to the tetrodotoxin-resistant component.	Capsaicin	176-185	calcitonin-related polypeptide alpha	Rattus norvegicus	194-198
8897896-8	1996	Our results suggest that a bronchodilator peptide with the profile of enzymatic cleavage of VIP also modulates capsaicin effects, since the increase in Pao in the presence of Thio + STI was significantly lower than Thio alone.	Capsaicin	111-120	VIP peptides	Cavia porcellus	92-95
8897896-2	1996	In the present study we measured the release of VIP-like immunoreactivity (VIP-LI) after tracheal infusion of capsaicin, histamine, and methacholine in isolated guinea pig lungs superfused through the trachea.	Capsaicin	110-119	VIP peptides	Cavia porcellus	48-51
8864557-8	1996	Pretreatment of MAB with capsaicin or ruthenium red inhibited ETX-induced CGRP release by 90% and 71%, respectively.	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
8895878-1	1996	Pituitary adenylate cyclase activating peptide (PACAP) is expressed in a population of capsaicin-sensitive primary sensory neurons of small to medium size in the rat.	Capsaicin	87-96	adenylate cyclase activating polypeptide 1	Rattus norvegicus	0-46
8895878-1	1996	Pituitary adenylate cyclase activating peptide (PACAP) is expressed in a population of capsaicin-sensitive primary sensory neurons of small to medium size in the rat.	Capsaicin	87-96	adenylate cyclase activating polypeptide 1	Rattus norvegicus	48-53
8886402-9	1996	NPY also significantly decreased plasma protein extravasation induced by capsaicin (1 mumol kg-1) but not by substance P (1 nmol kg-1).	Capsaicin	73-82	neuropeptide Y	Rattus norvegicus	0-3
23194965-0	1996	Dose-dependent reversal effects of Capsaicin on Interleukin-1alpha production is associated with the metabolism of arachidonic acid (leukotriene B(4) and prostaglandin E(2)) as well as nitric oxide production in human leukocytes.	Capsaicin	35-44	interleukin 1 alpha	Homo sapiens	48-66
8864563-7	1996	Capsaicin-induced hyperalgesia was prevented and reversed by the NK1 receptor antagonists CP 99994 (100 nmol) and RP 67580 (1 nmol).	Capsaicin	0-9	tachykinin receptor 1	Rattus norvegicus	65-77
9232670-3	1996	Inhibition of NEP with phosphoramidon caused cough, which was inhibited by systemic capsaicin treatment and by aerosols of a specific NK1 receptor antagonist FK 888.	Capsaicin	84-93	membrane metalloendopeptidase	Homo sapiens	14-17
8891596-4	1996	Pretreatment with CGRP or capsaicin, which evokes release of CGRP from cardiac sensory nerves, for 5 min produced a significant improvement of cardiac function, a reduction in the incidence of ventricular arrhythmia, and a decrease in the release of creatine phosphate kinase.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	18-22
8891596-4	1996	Pretreatment with CGRP or capsaicin, which evokes release of CGRP from cardiac sensory nerves, for 5 min produced a significant improvement of cardiac function, a reduction in the incidence of ventricular arrhythmia, and a decrease in the release of creatine phosphate kinase.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	61-65
8891596-5	1996	However, the cardioprotection provided by CGRP- or capsaicin-induced preconditioning was abolished by CGRP-(8-37) and ruthenium red, respectively.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	102-106
8843791-5	1996	Our results indicate that capsaicin treatment resulted in more neutrophils and higher levels of protein and TNF in the BAL fluid in response to intratracheal LPS, compared with vehicle treatment.	Capsaicin	26-35	tumor necrosis factor-like	Rattus norvegicus	108-111
8843791-7	1996	We found a modest increase in the concentration of TNF and nitrite in the supernatant of macrophages collected from capsaicin-treated rats, in comparison with vehicle-treated animals.	Capsaicin	116-125	tumor necrosis factor-like	Rattus norvegicus	51-54
8864546-14	1996	Subjective nasal obstruction, local discomfort, nasal secretions and NAR increase evoked by capsaicin were markedly reduced by NPY pretreatment (P < 0.05) when compared to saline or oxymetazoline.	Capsaicin	92-101	neuropeptide Y	Homo sapiens	127-130
8864546-17	1996	Pretreatment of the nasal mucosa with exogenous NPY reduces both secretagogue and vasodilator responses to subsequent application of capsaicin.	Capsaicin	133-142	neuropeptide Y	Homo sapiens	48-51
8864563-13	1996	Both low dose SP (1 nmol) and capsaicin (1 nmol)-induced hyperalgesia were potentiated by the kininase II inhibitor captopril (100 micrograms).	Capsaicin	30-39	angiotensin I converting enzyme	Rattus norvegicus	94-105
8864557-17	1996	The data suggest that ETX triggers the release of CGRP from capsaicin-sensitive sensory nerves innervating blood vessels.	Capsaicin	60-69	calcitonin-related polypeptide alpha	Rattus norvegicus	50-54
8864563-22	1996	IL-1ra (0.1 microgram) also blocked the development of and reversed an established capsaicin-induced hyperalgesia.	Capsaicin	83-92	interleukin 1 receptor antagonist	Rattus norvegicus	0-6
8784269-0	1996	Capsaicin-induced inhibition of mitogen and interleukin-2-stimulated T cell proliferation: its reversal by in vivo substance P administration.	Capsaicin	0-9	interleukin 2	Rattus norvegicus	44-57
8869765-0	1996	Calcitonin gene-related peptide is released from capsaicin-sensitive nerve fibres and induces vasodilatation of human cerebral arteries concomitant with activation of adenylyl cyclase.	Capsaicin	49-58	calcitonin related polypeptide alpha	Homo sapiens	0-31
8853942-6	1996	Neuropathic pain with a major cutaneous component may respond well to topical therapy with the Substance P depletor capsaicin to reduce elevated prostaglandin levels.	Capsaicin	116-125	tachykinin precursor 1	Homo sapiens	95-106
8886925-14	1996	Moreover, it seems likely that these compounds at a high dose can suppress vasodilatation and plasma extravasation induced by SP involved in capsaicin-induced edema.	Capsaicin	141-150	tachykinin 1	Mus musculus	126-128
8865073-12	1996	In conscious rats, perivagal application of capsaicin abolished the pancreatic response evoked by physiological doses of CCK and intraduodenal administration of maltose or hypertonic saline, confirming the physiological relevance of the observations in anaesthetized rats.	Capsaicin	44-53	cholecystokinin	Rattus norvegicus	121-124
8926258-6	1996	In capsaicin-pretreated animals, histamine infusion was associated with a significantly decreased hASL (hASL, cap11/hASL,cap0 = 0.58, P < 0.04).	Capsaicin	3-12	argininosuccinate lyase	Homo sapiens	98-102
8809823-12	1996	After neonatal capsaicin treatment the concentration of immunoreactive PACAP-38 as well as the number and intensity of PACAP-positive nerve fibres were reduced while vasoactive intestinal polypeptide immunoreactivity was unaffected.	Capsaicin	15-24	adenylate cyclase activating polypeptide 1	Rattus norvegicus	71-76
8809823-12	1996	After neonatal capsaicin treatment the concentration of immunoreactive PACAP-38 as well as the number and intensity of PACAP-positive nerve fibres were reduced while vasoactive intestinal polypeptide immunoreactivity was unaffected.	Capsaicin	15-24	adenylate cyclase activating polypeptide 1	Rattus norvegicus	119-124
8667028-5	1996	PDBu at 1 nM or 1-oleoyl-2-acetyl-sn-glycerol at 50 microM did not alter resting release of peptides, but augmented potassium- and capsaicin-stimulated release of both SP and CGRP approximately twofold.	Capsaicin	131-140	calcitonin-related polypeptide alpha	Rattus norvegicus	175-179
8764165-2	1996	To determine whether neuronal nicotine acetylcholine receptors (nAChR) are present on capsaicin-sensitive neurons, whole cell patch-clamp recordings were performed on rat trigeminal ganglion cells.	Capsaicin	86-95	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	30-62
8764165-2	1996	To determine whether neuronal nicotine acetylcholine receptors (nAChR) are present on capsaicin-sensitive neurons, whole cell patch-clamp recordings were performed on rat trigeminal ganglion cells.	Capsaicin	86-95	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	64-69
8814463-10	1996	The present results suggest that the difference in effects of the two NK1 receptor antagonists on the oedema response to capsaicin is due to species differences in affinities for the NK1 receptor in the mouse skin.	Capsaicin	121-130	tachykinin receptor 1	Mus musculus	70-82
8814463-10	1996	The present results suggest that the difference in effects of the two NK1 receptor antagonists on the oedema response to capsaicin is due to species differences in affinities for the NK1 receptor in the mouse skin.	Capsaicin	121-130	tachykinin receptor 1	Mus musculus	183-195
8967501-1	1996	A capsaicin-sensitive vagal afferent pathway was reported to mediate the effect of endogenous cholecystokinin (CCK) on pancreatic secretion in anesthetized rats.	Capsaicin	2-11	cholecystokinin	Rattus norvegicus	94-109
8967501-1	1996	A capsaicin-sensitive vagal afferent pathway was reported to mediate the effect of endogenous cholecystokinin (CCK) on pancreatic secretion in anesthetized rats.	Capsaicin	2-11	cholecystokinin	Rattus norvegicus	111-114
8967501-7	1996	Intraperitoneal CCK-8 markedly inhibited food intake and gastric emptying, and both effects were significantly attenuated in capsaicin-treated rats, indicating that capsaicin treatment successfully ablated vagal afferent fibers.	Capsaicin	165-174	cholecystokinin	Rattus norvegicus	16-19
8738215-8	1996	Pre-treatment of the rats with capsaicin caused a marked reduction of the PACAP-IR in the adrenal gland as well as in the superficial layers of the dorsal horn and caudal spinal trigeminal nucleus.	Capsaicin	31-40	adenylate cyclase activating polypeptide 1	Rattus norvegicus	74-79
8764661-0	1996	Involvement of cytokines in lipopolysaccharide-induced facilitation of CGRP release from capsaicin-sensitive nerves in the trachea: studies with interleukin-1beta and tumor necrosis factor-alpha.	Capsaicin	89-98	calcitonin-related polypeptide alpha	Rattus norvegicus	71-75
8764661-6	1996	We observed that capsaicin-induced (0.1 microM) tracheal CGRP release was significantly enhanced in the LPS-treated animals after 5 hr.	Capsaicin	17-26	calcitonin-related polypeptide alpha	Rattus norvegicus	57-61
8667012-0	1996	K252a modulates the expression of nerve growth factor-dependent capsaicin sensitivity and substance P levels in cultured adult rat dorsal root ganglion neurones.	Capsaicin	64-73	nerve growth factor	Rattus norvegicus	34-53
8667012-2	1996	The nerve growth factor-dependent appearance of capsaicin sensitivity and accumulation of the neuropeptide substance P were inhibited when dorsal root ganglion neurones were grown in the presence of low concentrations (100 nM) of K252a.	Capsaicin	48-57	nerve growth factor	Rattus norvegicus	4-23
12799856-4	1996	The model of neurogenic inflammation after stimulation of the trigeminal ganglion or systemic administration of capsaicin allows study of the inhibitory interactions between antimigraine compounds and peripheral trigeminal fibre terminals that sustain a sterile meningeal inflammation through release of allogenic and vasoactive neuropeptides, such as substance P and calcitonin gene-related peptide.	Capsaicin	112-121	tachykinin precursor 1	Homo sapiens	352-363
8764208-6	1996	Mucin secretion in response to the exogenous application of 5-HT occurs via two pathways: one is mediated by a 5-HT4-like receptor and is capsaicin sensitive but tetrodotoxin (TTX) insensitive, and one lacks the capsaicin-sensitive 5-HT4-mediated response but is TTX sensitive.	Capsaicin	138-147	solute carrier family 13 member 2	Rattus norvegicus	0-5
8764208-6	1996	Mucin secretion in response to the exogenous application of 5-HT occurs via two pathways: one is mediated by a 5-HT4-like receptor and is capsaicin sensitive but tetrodotoxin (TTX) insensitive, and one lacks the capsaicin-sensitive 5-HT4-mediated response but is TTX sensitive.	Capsaicin	212-221	solute carrier family 13 member 2	Rattus norvegicus	0-5
8739631-2	1996	In order to investigate central pathways mediating reflex changes in cardiovascular activity, immunohistochemical localization of cells expressing the immediate-early gene, c-fos, was used to identify central nervous responding to noxious electrical stimulation of mandibular, incisor tooth dentin or chemical (capsaicin) stimulation of tooth pulp in the anesthetized rat.	Capsaicin	311-320	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	173-178
8926258-6	1996	In capsaicin-pretreated animals, histamine infusion was associated with a significantly decreased hASL (hASL, cap11/hASL,cap0 = 0.58, P < 0.04).	Capsaicin	3-12	argininosuccinate lyase	Homo sapiens	104-108
8926258-6	1996	In capsaicin-pretreated animals, histamine infusion was associated with a significantly decreased hASL (hASL, cap11/hASL,cap0 = 0.58, P < 0.04).	Capsaicin	3-12	cathelicidin antimicrobial peptide	Cavia porcellus	110-115
8926258-6	1996	In capsaicin-pretreated animals, histamine infusion was associated with a significantly decreased hASL (hASL, cap11/hASL,cap0 = 0.58, P < 0.04).	Capsaicin	3-12	argininosuccinate lyase	Homo sapiens	104-108
8926258-8	1996	The notation cap0 and cap11 indicates capsaicin-pretreated airways given 0 or 11 micrograms/kg histamine, respectively; similarly, norm0 and norm11 indicate normal airways given 0 and 11 micrograms/kg histamine, respectively.	Capsaicin	38-47	cathelicidin antimicrobial peptide	Cavia porcellus	22-27
8700951-5	1996	Fifteen minutes later subjects were tested on the tongue tip with either capsaicin or menthol.	Capsaicin	73-82	TOR signaling pathway regulator	Homo sapiens	57-60
8783321-0	1996	Desensitization follows excitation of bladder primary afferents by intravesical capsaicin, as shown by c-fos activation in the rat spinal cord.	Capsaicin	80-89	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-108
8783321-2	1996	Two hours after capsaicin instillation in the bladder numerous Fos cells occurred in lamina I at T12-L2 and in lamina I, intermediolateral gray matter (ILG) and dorsal commissure (DCM) at L5-S1.	Capsaicin	16-25	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	63-66
8783321-4	1996	At this time, instillation of 1% acetic acid into the bladder of capsaicin-treated rats induced considerably fewer Fos cells than in animals that had been instilled only with the vehicle solution for capsaicin.	Capsaicin	65-74	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-118
8834409-1	1996	In our previous study, perineural application of capsaicin not only produced release and depletion of substance P from primary nociceptive afferent terminals, but also reduced GABA immunoreactivity in the superficial dorsal horn.	Capsaicin	49-58	tachykinin precursor 1	Homo sapiens	102-113
8834409-7	1996	Additionally, capsaicin-induced reduction of substance P immunoreactivity was partially blocked by spantide.	Capsaicin	14-23	tachykinin precursor 1	Homo sapiens	45-56
8834409-8	1996	These results suggest that capsaicin produces substance P release from primary nociceptive afferent terminals, and that substance P, in turn, activates the second-order GABAergic interneurons in the dorsal horn.	Capsaicin	27-36	tachykinin precursor 1	Homo sapiens	46-57
8703361-4	1996	At 0.5% capsaicin, there was complete loss of nerve fibres showing positive staining for CGRP and substance P at all time points.	Capsaicin	8-17	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
8868267-8	1996	hCGRP 8-37 significantly reduced both the CGRP- and capsaicin-mediated vasodilation in the nasal mucosa and the decrease of nasal cavity volume.	Capsaicin	52-61	Calcitonin gene-related peptide	Sus scrofa	1-5
8601380-9	1996	In addition, the amount of calcitonin gene-related peptide (CGRP) released in the isolated stomach in response to capsaicin (1 X 10(-5) M) was significantly lower in aged animals when compared to young rats.	Capsaicin	114-123	calcitonin-related polypeptide alpha	Rattus norvegicus	27-58
8601380-9	1996	In addition, the amount of calcitonin gene-related peptide (CGRP) released in the isolated stomach in response to capsaicin (1 X 10(-5) M) was significantly lower in aged animals when compared to young rats.	Capsaicin	114-123	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
8779966-3	1996	The gastric mucosal hyperemic effect of a low dose of CCK-8 (0.04 nmol/min iv infusion for 7 min) was abolished by inhibition of nitric oxide synthesis with NG-nitro-L-arginine methyl ester (15 mg/kg iv) and significantly blunted by defunctionalization of afferent neurons with a neurotoxic dose of capsaicin (125 mg/kg sc).	Capsaicin	299-308	cholecystokinin	Rattus norvegicus	54-57
8834108-6	1996	This suggests that expression of capsaicin sensitivity in DRG is maximal at levels of NGF found in normal animals.	Capsaicin	33-42	nerve growth factor	Rattus norvegicus	86-89
8740609-6	1996	Endothelin-3 concentration significantly increased after intravenous injection of capsaicin, whereas ET-1 levels remained unchanged.	Capsaicin	82-91	endothelin 3	Rattus norvegicus	0-12
8740610-5	1996	NGF injection caused edema which was absent in rats pretreated with compound 48/80 as well as in rats treated neonatally with capsaicin ("capsaicin denervation").	Capsaicin	126-135	nerve growth factor	Rattus norvegicus	0-3
8740610-5	1996	NGF injection caused edema which was absent in rats pretreated with compound 48/80 as well as in rats treated neonatally with capsaicin ("capsaicin denervation").	Capsaicin	138-147	nerve growth factor	Rattus norvegicus	0-3
8740610-7	1996	On each day, NGF injection caused a decrease in thermal nociceptive threshold which lasted for less than 3 h. Capsaicin denervation, but not treatment with indomethacin, abolished NGF-induced thermal hyperalgesia.	Capsaicin	110-119	nerve growth factor	Rattus norvegicus	180-183
8740610-11	1996	NGF-induced thermal hyperalgesia most likely was caused by an increased sensitivity of peripheral endings of capsaicin sensitive afferents.	Capsaicin	109-118	nerve growth factor	Rattus norvegicus	0-3
8701024-8	1996	CGRP(8-37) (0.3-1.0 microM) produced a partial inhibitory effect (about 50% inhibition) of the relaxant response to capsaicin.	Capsaicin	116-125	calcitonin related polypeptide alpha	Homo sapiens	0-4
8701024-14	1996	Endogenous CGRP mediates part of the relaxant response evoked by stimulation of capsaicin-sensitive primary afferent nerves in the circular muscle of guinea-pig colon, while it is not involved in the apamin and L-NOARG-resistant nonadrenergic noncholinergic (NANC) relaxation produced by electrical field stimulation of intrinsic inhibitory nerves.	Capsaicin	80-89	calcitonin related polypeptide alpha	Homo sapiens	11-15
8758688-7	1996	Pretreated MAB with capsaicin or ruthenium red inhibited ETX-induced release of CGRP by 90% and 65% respectively.	Capsaicin	20-29	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
8758688-9	1996	The data suggest that ETX directly trigger the release of CGRP from capsaicin-sensitive sensory nerve innervating blood vessels.	Capsaicin	68-77	calcitonin-related polypeptide alpha	Rattus norvegicus	58-62
8730431-4	1996	Local application of capsaicin depletes the peripheral neurons of substance P and may block the conduction of pain or pruritus.	Capsaicin	21-30	tachykinin precursor 1	Homo sapiens	66-77
8800374-12	1996	The CGRP-receptor antagonist hCGRP 8-37 markedly reduced the capsaicin-evoked vascular effects in the pig nasal mucosa and superficial skin.	Capsaicin	61-70	Calcitonin gene-related peptide	Sus scrofa	4-8
8800374-17	1996	infusion of hCGRP 8-37, closely resembling the results obtained from the capsaicin challenge before and after CGRP-receptor blockade.	Capsaicin	73-82	Calcitonin gene-related peptide	Sus scrofa	13-17
8772504-4	1996	Severity of inflammation was markedly increased 3 and 7 days after induction of colitis in the capsaicin-pretreated group compared with the vehicle group as determined by a macroscopic damage score (at 3 days, 12.0 +/- 0.7 vs. 7.5 +/- 1.5; at 7 days, 12.2 +/- 0.8 vs. 6.5 +/- 0.8; P < 0.05), by histology (ulceration score at 3 days, 82 +/- 12 vs. 40 +/- 11%; at 7 days, 92 +/- 5 vs. 46 +/- 13%; P < 0.05), and by myeloperoxidase activity (at 3 days, 133 +/- 30 vs. 42 +/- 14 U/mg protein; at 7 days, 76 +/- 11 vs. 39 +/- 11 U/mg protein; P < 0.05).	Capsaicin	95-104	myeloperoxidase	Rattus norvegicus	420-435
8699918-0	1996	Capsaicin-induced biphasic oxygen uptake in rat muscle: antagonism by capsazepine and ruthenium red provides further evidence for peripheral vanilloid receptor subtypes (VN1/VN2).	Capsaicin	0-9	vomeronasal 1 receptor 105	Rattus norvegicus	170-173
8699918-0	1996	Capsaicin-induced biphasic oxygen uptake in rat muscle: antagonism by capsazepine and ruthenium red provides further evidence for peripheral vanilloid receptor subtypes (VN1/VN2).	Capsaicin	0-9	vomeronasal 1 receptor 102	Rattus norvegicus	174-177
8573592-1	1996	Capsaicin is a new naturally occurring inhibitor of proton-pumping NADH-ubiquinone oxidoreductase (NDH-1), that competitively acts against ubiquinone.	Capsaicin	0-9	NADH dehydrogenase subunit 1	Solanum tuberosum	99-104
8573592-2	1996	A series of capsaicin analogues was synthesized to examine the structural factors required for the inhibitory action and to probe the structural property of the ubiquinone catalytic site of various NADH-ubiquinone reductases, including non-proton-pumping enzyme (NDH-2), from bovine heart mitochondria, potato tuber (Solanum tuberosum, L) mitochondria and Escherichia coli (GR 19N) plasma membranes.	Capsaicin	12-21	NADH dehydrogenase subunit 2	Solanum tuberosum	263-268
8573592-3	1996	Some synthetic capsaicins were fairly potent inhibitors of each of the three NDH-1 compared with the potent rotenone and piericidin A.	Capsaicin	15-25	NADH dehydrogenase subunit 1	Solanum tuberosum	77-82
8573592-4	1996	Synthetic capsaicin analogues inhibited all three NDH-1 activities in a competitive manner against an exogenous quinone.	Capsaicin	10-19	NADH dehydrogenase subunit 1	Solanum tuberosum	50-55
8573592-7	1996	These results might be explained assuming that the ubiquinone catalytic site of NDH-1 is spacious enough to accommodate a variety of structurally different capsaicin analogues in a dissimilar manner.	Capsaicin	156-165	NADH dehydrogenase subunit 1	Solanum tuberosum	80-85
8573592-11	1996	The sensitivity to the inhibition by synthetic capsaicins remarkably differed between NDH-1 and NDH-2, supporting the notion that the sensitivity against capsaicin inhibition correlates well with the presence of an energy coupling site in the enzyme (Yagi, T. (1990) Arch.	Capsaicin	47-57	NADH dehydrogenase subunit 1	Solanum tuberosum	86-91
8573592-11	1996	The sensitivity to the inhibition by synthetic capsaicins remarkably differed between NDH-1 and NDH-2, supporting the notion that the sensitivity against capsaicin inhibition correlates well with the presence of an energy coupling site in the enzyme (Yagi, T. (1990) Arch.	Capsaicin	47-57	NADH dehydrogenase subunit 2	Solanum tuberosum	96-101
8573592-11	1996	The sensitivity to the inhibition by synthetic capsaicins remarkably differed between NDH-1 and NDH-2, supporting the notion that the sensitivity against capsaicin inhibition correlates well with the presence of an energy coupling site in the enzyme (Yagi, T. (1990) Arch.	Capsaicin	47-56	NADH dehydrogenase subunit 1	Solanum tuberosum	86-91
8573592-11	1996	The sensitivity to the inhibition by synthetic capsaicins remarkably differed between NDH-1 and NDH-2, supporting the notion that the sensitivity against capsaicin inhibition correlates well with the presence of an energy coupling site in the enzyme (Yagi, T. (1990) Arch.	Capsaicin	47-56	NADH dehydrogenase subunit 2	Solanum tuberosum	96-101
8573592-15	1996	It is noteworthy that several synthetic capsaicins discriminated between NDH-1 and NDH-2 much better than natural capsaicin.	Capsaicin	40-50	NADH dehydrogenase subunit 1	Solanum tuberosum	73-78
8573592-15	1996	It is noteworthy that several synthetic capsaicins discriminated between NDH-1 and NDH-2 much better than natural capsaicin.	Capsaicin	40-50	NADH dehydrogenase subunit 2	Solanum tuberosum	83-88
8573592-15	1996	It is noteworthy that several synthetic capsaicins discriminated between NDH-1 and NDH-2 much better than natural capsaicin.	Capsaicin	40-49	NADH dehydrogenase subunit 1	Solanum tuberosum	73-78
8573592-15	1996	It is noteworthy that several synthetic capsaicins discriminated between NDH-1 and NDH-2 much better than natural capsaicin.	Capsaicin	40-49	NADH dehydrogenase subunit 2	Solanum tuberosum	83-88
8871136-4	1996	Moreover, on guinea pig isolated main bronchi, SCA40 can exert a preventive effect on contractions induced by acetylcholine, neurokinin A or capsaicin, that is, it shifts to the right the concentration-effect curves of these substances, whereas cromakalim has no such effect.	Capsaicin	141-150	coiled-coil domain containing 88C	Homo sapiens	47-52
8699918-3	1996	Low concentrations of capsazepine selectively inhibited the increased VO2 produced by the putative VN1 receptor at submicromolar concentrations of capsaicin, while the inhibition of VO2 produced by high concentrations of capsaicin (putative VN2) was enhanced.	Capsaicin	147-156	vomeronasal 1 receptor 105	Rattus norvegicus	99-102
8699918-6	1996	Low concentrations of the capsaicin antagonist ruthenium red selectively blocked the putative VN2 receptor-mediated effects produced by high concentrations of capsaicin.	Capsaicin	26-35	vomeronasal 1 receptor 102	Rattus norvegicus	94-97
8699918-6	1996	Low concentrations of the capsaicin antagonist ruthenium red selectively blocked the putative VN2 receptor-mediated effects produced by high concentrations of capsaicin.	Capsaicin	159-168	vomeronasal 1 receptor 102	Rattus norvegicus	94-97
8801523-6	1996	Neonatal treatment with capsaicin, a neurotoxin for primary afferent neurons, or celiac/superior mesenteric ganglionectomy depletes CGRP-containing fibers in the biliary tract, and reduces those associated with the portal vein.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	132-136
8801523-8	1996	Radioimmunoassay studies show a reduction of CGRP-immunoreactive contents in the biliary tract and portal vein by 84% and 65%, respectively, following capsaicin treatment, and by 80% and 66%, respectively, following ganglionectomy.	Capsaicin	151-160	calcitonin-related polypeptide alpha	Rattus norvegicus	45-49
8719796-0	1995	Attenuation by valproate of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin.	Capsaicin	108-117	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	28-33
8597423-17	1995	Capsaicin pretreatment diminished the enhanced cytokine production in response to stress, such that levels of TNF alpha and IL-6 approximated those of control mice.	Capsaicin	0-9	tumor necrosis factor	Mus musculus	110-119
8597423-17	1995	Capsaicin pretreatment diminished the enhanced cytokine production in response to stress, such that levels of TNF alpha and IL-6 approximated those of control mice.	Capsaicin	0-9	interleukin 6	Mus musculus	124-128
9387374-0	1996	[Influence of electroacupuncture and capsaicin treatment on AChE activity and [3H]-QNB binding sites in the spinal dorsal horn].	Capsaicin	37-46	acetylcholinesterase	Rattus norvegicus	60-64
8837963-3	1995	The results demonstrate that when substance P is released from human skin by incubation in the presence of capsaicin (10(-5)M), no histamine is released from human isolated skin fragments.	Capsaicin	107-116	tachykinin precursor 1	Homo sapiens	34-45
8666097-8	1995	Capsaicin treatment also significantly elevated vascular CGRP binding.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	57-61
8596661-7	1995	Fos-immunoreactive nuclei were observed in dorsomedial trigeminal caudalis bilaterally when a restricted area on the tip of the tongue was stimulated with capsaicin, but were located predominantly ipsilaterally following stimulation of the lateral tongue.	Capsaicin	155-164	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
8596661-9	1995	Numbers of Fos-immunoreactive nuclei were significantly increased following nicotine and capsaicin in ventrolateral trigeminal nucleus caudalis and nucleus of the solitary tract.	Capsaicin	89-98	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	11-14
8750923-0	1995	The inhibitory modulation of guinea-pig intestinal peristalsis caused by capsaicin involves calcitonin gene-related peptide and nitric oxide.	Capsaicin	73-82	calcitonin related polypeptide alpha	Homo sapiens	92-123
8750923-7	1995	Further experiments, performed in the presence of a low concentration of atropine (10 nM) showed that the calcitonin gene-related peptide (CGRP) antagonist human alpha-calcitonin gene-related peptide (8-37) [hCGRP(8-37); 10 microM] attenuated the delayed inhibitory effect of capsaicin on peristalsis, but did not influence baseline peristaltic activity and the capsaicin-induced facilitation of peristalsis.	Capsaicin	276-285	calcitonin related polypeptide alpha	Homo sapiens	106-137
8750923-7	1995	Further experiments, performed in the presence of a low concentration of atropine (10 nM) showed that the calcitonin gene-related peptide (CGRP) antagonist human alpha-calcitonin gene-related peptide (8-37) [hCGRP(8-37); 10 microM] attenuated the delayed inhibitory effect of capsaicin on peristalsis, but did not influence baseline peristaltic activity and the capsaicin-induced facilitation of peristalsis.	Capsaicin	276-285	calcitonin related polypeptide alpha	Homo sapiens	139-143
8750923-7	1995	Further experiments, performed in the presence of a low concentration of atropine (10 nM) showed that the calcitonin gene-related peptide (CGRP) antagonist human alpha-calcitonin gene-related peptide (8-37) [hCGRP(8-37); 10 microM] attenuated the delayed inhibitory effect of capsaicin on peristalsis, but did not influence baseline peristaltic activity and the capsaicin-induced facilitation of peristalsis.	Capsaicin	362-371	calcitonin related polypeptide alpha	Homo sapiens	106-137
8750923-7	1995	Further experiments, performed in the presence of a low concentration of atropine (10 nM) showed that the calcitonin gene-related peptide (CGRP) antagonist human alpha-calcitonin gene-related peptide (8-37) [hCGRP(8-37); 10 microM] attenuated the delayed inhibitory effect of capsaicin on peristalsis, but did not influence baseline peristaltic activity and the capsaicin-induced facilitation of peristalsis.	Capsaicin	362-371	calcitonin related polypeptide alpha	Homo sapiens	139-143
8750923-11	1995	The initial stimulant action of capsaicin on peristalsis is independent of tachykinins acting via NK1 or NK2 receptors, while the delayed capsaicin-induced depression of peristalsis involves CGRP and NO.	Capsaicin	138-147	calcitonin related polypeptide alpha	Homo sapiens	191-195
8535059-2	1995	Capsaicin, the active principle of hot chili pepper, is thought to selectively stimulate unmyelinated C fibre afferent neurons and cause the release of substance P.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	152-163
8608789-0	1995	Tumor necrosis factor-alpha prevents interleukin-1 beta from augmenting capsaicin-induced vasodilatation in the rat skin.	Capsaicin	72-81	tumor necrosis factor	Rattus norvegicus	0-27
8608789-0	1995	Tumor necrosis factor-alpha prevents interleukin-1 beta from augmenting capsaicin-induced vasodilatation in the rat skin.	Capsaicin	72-81	interleukin 1 beta	Rattus norvegicus	37-55
8608789-1	1995	The effect of tumor necrosis factor-alpha (TNF alpha) and tumor necrosis factor-beta (TNF beta) on the capsaicin-induced increase in cutaneous blood flow was investigated in anaesthetized rats.	Capsaicin	103-112	tumor necrosis factor	Rattus norvegicus	14-41
8608789-1	1995	The effect of tumor necrosis factor-alpha (TNF alpha) and tumor necrosis factor-beta (TNF beta) on the capsaicin-induced increase in cutaneous blood flow was investigated in anaesthetized rats.	Capsaicin	103-112	lymphotoxin alpha	Rattus norvegicus	58-84
8608789-1	1995	The effect of tumor necrosis factor-alpha (TNF alpha) and tumor necrosis factor-beta (TNF beta) on the capsaicin-induced increase in cutaneous blood flow was investigated in anaesthetized rats.	Capsaicin	103-112	lymphotoxin alpha	Rattus norvegicus	86-94
8608789-5	1995	This enhancement of the cutaneous hyperaemic response to capsaicin was absent when interleukin-1 beta (50 pg) was co-injected with TNF alpha (500 pg or 5000 pg).	Capsaicin	57-66	interleukin 1 beta	Rattus norvegicus	83-101
8608789-5	1995	This enhancement of the cutaneous hyperaemic response to capsaicin was absent when interleukin-1 beta (50 pg) was co-injected with TNF alpha (500 pg or 5000 pg).	Capsaicin	57-66	tumor necrosis factor	Rattus norvegicus	131-140
7478647-5	1995	In addition, an in vivo study was conducted whereby gerbils were injected with capsaicin to eliminate substance P-containing fibers before sympathectomy with 6-hydroxydopamine.	Capsaicin	79-88	tachykinin 1	Mus musculus	102-113
7478647-20	1995	Substance P has thus been shown to induce calcium release from membranous bone in vitro, whereas capsaicin, a substance P-specific sensory neurolytic chemical, eliminates the in vivo osteoclast-inductive effects of 6-hydroxydopamine when given 12 hours before treatment.	Capsaicin	97-106	tachykinin 1	Mus musculus	110-121
8762448-6	1995	The above results suggest that the observed release of CGRP in MAB was mediated by capsaicin-sensitive sensory nerve endings, as a result of Ca(2+)-induced Ca2+ release from the intracellular Ca2+ store which is sensitive to ruthenium red.	Capsaicin	83-92	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
8595209-9	1995	Our findings suggest that RTX can cause changes (messenger plasticity) in galanin, VIP and NOS expression in capsaicin-sensitive sensory neurones of the rat, similar to those described following axotomy.	Capsaicin	109-118	vasoactive intestinal peptide	Rattus norvegicus	83-86
8597880-0	1995	Involvement of substance P as a mediator in capsaicin-induced mouse ear oedema.	Capsaicin	44-53	tachykinin 1	Mus musculus	15-26
8597880-1	1995	We examined the involvement of substance P (SP) in mouse ear oedema induced by topical application of capsaicin (250 micrograms/ear).	Capsaicin	102-111	tachykinin 1	Mus musculus	31-42
8597880-13	1995	These results indicate that tachyphylaxis of capsaicin-induced oedema is reversible and suggest that this response may be due mainly to a reduction of SP in sensory neurones but not to any loss of responsiveness of NK1 receptors.	Capsaicin	45-54	tachykinin 1	Mus musculus	151-153
8597880-14	1995	We also conclude that SP and NK1 receptors are involved predominantly in the development of capsaicin-induced mouse ear oedema.	Capsaicin	92-101	tachykinin 1	Mus musculus	22-24
8597880-14	1995	We also conclude that SP and NK1 receptors are involved predominantly in the development of capsaicin-induced mouse ear oedema.	Capsaicin	92-101	tachykinin 1	Mus musculus	29-32
8637627-8	1995	Both in vivo and in vitro studies showed that capsaicin caused a parallel release of PACAP-like immunoreactivity and CGRP-like immunoreactivity from the uvea.	Capsaicin	46-55	LOW QUALITY PROTEIN: pituitary adenylate cyclase-activating polypeptide	Oryctolagus cuniculus	85-90
8535059-3	1995	Prolonged application of capsaicin reversibly depletes stores of substance P, and possibly other neurotransmitters, from sensory nerve endings.	Capsaicin	25-34	tachykinin precursor 1	Homo sapiens	65-76
12506420-6	1995	In contrast, ruthenium red (1 x 10(-5) M), capsaicin antagonist, almost completely prevented acid (pH 4.0)-stimulated CGRP release.	Capsaicin	43-52	calcitonin-related polypeptide alpha	Rattus norvegicus	118-122
8586125-12	1995	Aerosolized capsaicin (30 microM) induced cough was also reduced by 3 and 10 mg.mL-1 aerosolized fenspiride, but no significant effect was found with 1 mg.mL-1.	Capsaicin	12-21	L1 cell adhesion molecule	Mus musculus	80-84
7653572-7	1995	Moreover, the action of CAP on secretin release was significantly inhibited in the recipient rats pretreated with TTX, BSV, and topical applications of capsaicin but was not suppressed in the recipient rats pretreated with atropine, hexamethonium, or propranolol.	Capsaicin	152-161	secretin	Rattus norvegicus	31-39
8847833-8	1995	Furthermore, 5-HT2-receptor antagonists partly prevented ear edema in response to substance P (SP), a putative mediator or capsaicin-induced edema, and compound 48/80, a releaser of vasoactive amines form mast cells.	Capsaicin	123-132	tachykinin 1	Mus musculus	82-93
8847833-8	1995	Furthermore, 5-HT2-receptor antagonists partly prevented ear edema in response to substance P (SP), a putative mediator or capsaicin-induced edema, and compound 48/80, a releaser of vasoactive amines form mast cells.	Capsaicin	123-132	tachykinin 1	Mus musculus	95-97
7477920-4	1995	Pretreatment of rats with capsaicin or administration of dexamethasone completely prevented the interleukin-1 beta effect.	Capsaicin	26-35	interleukin 1 beta	Rattus norvegicus	96-114
8542301-7	1995	Intraperitoneal administration of ondansetron or perivagal capsaicin treatment significantly reduced the duration of MMC disruption and attenuated markedly c-fos staining in the 3 brain sites.	Capsaicin	59-68	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	156-161
8542301-9	1995	Blockade of both c-fos expression and MMC disruption by systemic ondansetron and by perivagal capsaicin indicates that some brainstem nuclei are involved in digestive disturbances after intestinal anaphylaxis, and reflects an involvement of peripheral 5-HT3 receptors on vagal afferents.	Capsaicin	94-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
8542301-10	1995	The reduction of c-fos staining in NTS as well as in LPB and PVN after perivagal capsaicin suggests that the NTS is the primary relay in the activation of the central nervous system during intestinal allergic challenge.	Capsaicin	81-90	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	17-22
7653572-8	1995	Furthermore, perivagal and duodenojejunal mucosal application of capsaicin abolished the pancreatic secretory response to secretin at 5 pmol.kg-1.h-1.	Capsaicin	65-74	secretin	Rattus norvegicus	122-130
8575048-8	1995	Moreover, CAP administration also enhanced the level of IL-2 even in immunosuppression group induced by T II treatment.	Capsaicin	10-13	interleukin 2	Rattus norvegicus	56-60
7675216-6	1995	After neonatal capsaicin treatment the intensity of the neuropeptide Y immunoreactivity was increased, more neuropeptide Y-positive nerve bundles were found and immunoreactive cell bodies were observed regularly in the adventitia of the ureter.	Capsaicin	15-24	neuropeptide Y	Rattus norvegicus	56-70
7675216-6	1995	After neonatal capsaicin treatment the intensity of the neuropeptide Y immunoreactivity was increased, more neuropeptide Y-positive nerve bundles were found and immunoreactive cell bodies were observed regularly in the adventitia of the ureter.	Capsaicin	15-24	neuropeptide Y	Rattus norvegicus	108-122
7675216-8	1995	This loss of capsaicin-sensitive afferent nerves evokes neuroplastic changes resulting in a hyperinnervation by neuropeptide Y-immunoreactive, presumably sympathetic fibres.	Capsaicin	13-22	neuropeptide Y	Rattus norvegicus	112-126
8846403-2	1995	CGRP is synthesized and released from small, capsaicin-sensitive sensory nerves.	Capsaicin	45-54	calcitonin related polypeptide alpha	Homo sapiens	0-4
7473211-7	1995	Capsaicin was applied perineurally to either the left (Cap-L) or right (Cap-R) sciatic nerve of halothane-anaesthetized male Han Wistar rats.	Capsaicin	0-9	S100 calcium-binding protein A4	Rattus norvegicus	55-60
8846404-6	1995	did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperemic response to capsaicin.	Capsaicin	125-134	interleukin 1 beta	Rattus norvegicus	65-74
8846404-1	1995	In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry.	Capsaicin	137-146	interleukin 1 beta	Rattus norvegicus	51-69
8846404-8	1995	Systemic pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-induced hyperemia and prevented the facilitatory effect of IL-1 beta.	Capsaicin	48-57	interleukin 1 beta	Rattus norvegicus	139-148
8846404-10	1995	These data indicate that IL-1 beta but not TNF enhances the cutaneous hyperemic response to capsaicin.	Capsaicin	92-101	interleukin 1 beta	Rattus norvegicus	25-34
8846404-1	1995	In phenobarbitone-anesthetized rats the effects of interleukin 1 beta (IL-1 beta) and tumor necrosis factors (TNFs) were examined on the capsaicin-induced increase of plantar cutaneous blood flow in the rat hind paw as measured by laser Doppler flowmetry.	Capsaicin	137-146	interleukin 1 beta	Rattus norvegicus	71-80
8846404-3	1995	IL-1 beta was without effect on blood flow by its own but dose dependently enhanced the hyperemia due to capsaicin (0.3 microgram).	Capsaicin	105-114	interleukin 1 beta	Rattus norvegicus	0-9
8846425-7	1995	A role for NK2 receptor stimulation has also been clearly demonstrated in bronchoconstriction induced by various agents known to induce the release of tachykinins (capsaicin, resiniferatoxin, citric acid, sodium metabisulfite diethyl ether, serotonin, and bradykinin), in allergen-induced airway constriction in the guinea pig sensitized to ovalbumin, and in hyperpnea-induced bronchoconstriction.	Capsaicin	164-173	substance-K receptor	Cavia porcellus	11-23
7541004-4	1995	METHODS: Gastroprotection by gastrin 17 against ethanol-induced gross and histological damage was studied after capsaicin-induced defunctionalization of afferent neurons, pretreatment with the calcitonin gene-related peptide receptor antagonist human calcitonin gene-related peptide8-37, anti-calcitonin gene-related peptide antibodies, and the NO synthase inhibitor NG-nitro-L-arginine.	Capsaicin	112-121	gastrin	Rattus norvegicus	29-36
8846441-4	1995	Electrical stimulation of intramural nerves in the guinea-pig ureter produces a transient membrane hyperpolarization, which is blocked by glibenclamide or by capsaicin pretreatment, enhanced in a low-K medium, and inhibited by a CGRP receptor antagonist.	Capsaicin	158-167	calcitonin related polypeptide alpha	Homo sapiens	229-233
8846441-6	1995	The refractory period of the guinea-pig ureter is markedly and similarly reduced by capsaicin pretreatment or administration of a CGRP receptor antagonist, indicating that endogenous CGRP can modulate the maximal frequency of ureteral peristalsis.	Capsaicin	84-93	calcitonin related polypeptide alpha	Homo sapiens	183-187
8846444-2	1995	(i) Capsaicin evoked a concentration-dependent calcitonin gene related peptide (CGRP) release from the trachea.	Capsaicin	4-13	calcitonin-related polypeptide alpha	Rattus norvegicus	47-78
8846444-2	1995	(i) Capsaicin evoked a concentration-dependent calcitonin gene related peptide (CGRP) release from the trachea.	Capsaicin	4-13	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
8846444-8	1995	These results suggest that the effect of capsaicin on tracheal CGRP release occurs via activation of specific capsaicin receptors on primary sensory C-fibers, while protons act at a different site from that acted upon by capsaicin in the trachea.	Capsaicin	41-50	calcitonin-related polypeptide alpha	Rattus norvegicus	63-67
8846444-8	1995	These results suggest that the effect of capsaicin on tracheal CGRP release occurs via activation of specific capsaicin receptors on primary sensory C-fibers, while protons act at a different site from that acted upon by capsaicin in the trachea.	Capsaicin	110-119	calcitonin-related polypeptide alpha	Rattus norvegicus	63-67
7611400-11	1995	In subsequent studies, we demonstrated that perivagal treatment 4 days before with the sensory neurotoxin, capsaicin, abolished gastric motor response to secretin but did not affect contraction evoked by electrical vagal stimulation.	Capsaicin	107-116	secretin	Rattus norvegicus	154-162
7790881-1	1995	Capsaicin stimulates cyclic GMP production via nitric oxide (NO) (or another nitrosyl factor) in dorsal root ganglion (DRG) neurons maintained in culture.	Capsaicin	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	28-31
7790881-2	1995	The purpose of the present study was to characterize further capsaicin stimulation of cyclic GMP production in DRG cells maintained in culture, investigate other algesic and/or inflammatory agents for effects on cyclic GMP production, and examine cells responsible for NO production and cyclic GMP production.	Capsaicin	61-70	5'-nucleotidase, cytosolic II	Homo sapiens	93-96
7790881-3	1995	Capsaicin stimulation of cyclic GMP production in DRG cells was dose dependent, receptor mediated, and attenuated by hemoglobin.	Capsaicin	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	32-35
7790881-7	1995	Capsaicin pretreatment of neuronal DRG cultures, which destroys capsaicin-sensitive (small diameter) afferent neurons, attenuated capsaicin- and bradykinin-stimulated cyclic GMP production but did not affect basal or sodium nitroprusside-stimulated cyclic GMP production.	Capsaicin	0-9	kininogen 1	Homo sapiens	145-155
7790881-7	1995	Capsaicin pretreatment of neuronal DRG cultures, which destroys capsaicin-sensitive (small diameter) afferent neurons, attenuated capsaicin- and bradykinin-stimulated cyclic GMP production but did not affect basal or sodium nitroprusside-stimulated cyclic GMP production.	Capsaicin	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	174-177
7790881-7	1995	Capsaicin pretreatment of neuronal DRG cultures, which destroys capsaicin-sensitive (small diameter) afferent neurons, attenuated capsaicin- and bradykinin-stimulated cyclic GMP production but did not affect basal or sodium nitroprusside-stimulated cyclic GMP production.	Capsaicin	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	256-259
7790881-7	1995	Capsaicin pretreatment of neuronal DRG cultures, which destroys capsaicin-sensitive (small diameter) afferent neurons, attenuated capsaicin- and bradykinin-stimulated cyclic GMP production but did not affect basal or sodium nitroprusside-stimulated cyclic GMP production.	Capsaicin	64-73	kininogen 1	Homo sapiens	145-155
7790881-7	1995	Capsaicin pretreatment of neuronal DRG cultures, which destroys capsaicin-sensitive (small diameter) afferent neurons, attenuated capsaicin- and bradykinin-stimulated cyclic GMP production but did not affect basal or sodium nitroprusside-stimulated cyclic GMP production.	Capsaicin	130-139	5'-nucleotidase, cytosolic II	Homo sapiens	174-177
7790881-9	1995	Capsaicin evoked cyclic GMP production in nonneuronal DRG cultures in the presence but not in the absence of apposed neuronal DRG cultures.	Capsaicin	0-9	5'-nucleotidase, cytosolic II	Homo sapiens	24-27
8521150-11	1995	We suggest that the attenuated age-associated increase in circulating CGRP (derived mainly from capsaicin-sensitive nerves) in the Cap-Des rat results in a lower degree of aging-associated insulin-resistance, hence in a lesser degree of obesity.	Capsaicin	96-105	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74
7560753-6	1995	A prolonged depolarization was also produced by local application of capsaicin (1 mM), which releases substance P and CGRP from afferent nerve terminals.	Capsaicin	69-78	tachykinin precursor 1	Homo sapiens	102-113
8548184-0	1995	Hypotensive effect of 13-hydroxylinoleic acid in the rat: mediation via the release of a CGRP-like mediator from capsaicin-sensitive nerves.	Capsaicin	113-122	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
7611400-12	1995	Similarly, we also showed that gastroduodenal application of capsaicin for 30 min also markedly reduced gastric response to secretin.	Capsaicin	61-70	secretin	Rattus norvegicus	124-132
7671996-5	1995	Capsaicin (1 microM) inhibited sympathetic twitches, and this effect was partially antagonized by human CGRP-(8-37).	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	104-108
7556405-6	1995	Further indication that CGRP can promote the histamine action was obtained in capsaicin-denervated rats, where co-injection of CGRP (0.3 pmol) increased the edema response to intraplantar histamine.	Capsaicin	78-87	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
7556405-6	1995	Further indication that CGRP can promote the histamine action was obtained in capsaicin-denervated rats, where co-injection of CGRP (0.3 pmol) increased the edema response to intraplantar histamine.	Capsaicin	78-87	calcitonin-related polypeptide alpha	Rattus norvegicus	127-131
7563973-7	1995	Furthermore, prior administration of tetrodotoxin, the calcitonin gene-related peptide (CGRP) antagonist hCGRP or NG-nitro-L-arginine attenuated the gastroprotection of FRG-8813 as well as that of capsaicin.	Capsaicin	197-206	calcitonin-related polypeptide alpha	Rattus norvegicus	55-86
7563973-7	1995	Furthermore, prior administration of tetrodotoxin, the calcitonin gene-related peptide (CGRP) antagonist hCGRP or NG-nitro-L-arginine attenuated the gastroprotection of FRG-8813 as well as that of capsaicin.	Capsaicin	197-206	calcitonin-related polypeptide alpha	Rattus norvegicus	88-92
7563973-7	1995	Furthermore, prior administration of tetrodotoxin, the calcitonin gene-related peptide (CGRP) antagonist hCGRP or NG-nitro-L-arginine attenuated the gastroprotection of FRG-8813 as well as that of capsaicin.	Capsaicin	197-206	calcitonin related polypeptide alpha	Homo sapiens	105-110
7672010-7	1995	abolished the 5-HT- but not the capsaicin-stimulated bradycardia, indicating that 5-HT and capsaicin acted via different trigger mechanisms (5-HT3 receptor-dependent and -independent, respectively).	Capsaicin	91-100	5-hydroxytryptamine receptor 3A	Rattus norvegicus	141-155
7791341-6	1995	In normal gallbladders, CGRP release was stimulated sixfold over basal by capsaicin (10(-5) M) to 363 +/- 75 pg per gram of muscle per 2 min.	Capsaicin	74-83	calcitonin related polypeptide alpha	Homo sapiens	24-28
7791341-9	1995	In gallbladders with gallstones, capsaicin-induced CGRP release was 74 +/- 16 pg per gram of muscle per 2 min (20% of normal, P < 0.001).	Capsaicin	33-42	calcitonin related polypeptide alpha	Homo sapiens	51-55
7545124-1	1995	We previously demonstrated that the bradykinin-induced contraction of human isolated small bronchi is inhibited by indomethacin, capsaicin (N-methyl-N-6-nonenamide) and ruthenium red but not by tachykinin receptor antagonists.	Capsaicin	129-138	kininogen 1	Homo sapiens	36-46
7545124-7	1995	The inhibitory effect of ruthenium red and capsaicin on the bradykinin response may be due to inhibition of thromboxane A2 release or arachidonic mobilisation.	Capsaicin	43-52	kininogen 1	Homo sapiens	60-70
7762663-1	1995	Stimulation of capsaicin-sensitive sensory nerves induces gastric mucosal hyperemia, which is mediated in part by both calcitonin gene-related peptide (CGRP) and nitric oxide (NO).	Capsaicin	15-24	calcitonin related polypeptide alpha	Homo sapiens	119-150
7762663-1	1995	Stimulation of capsaicin-sensitive sensory nerves induces gastric mucosal hyperemia, which is mediated in part by both calcitonin gene-related peptide (CGRP) and nitric oxide (NO).	Capsaicin	15-24	calcitonin related polypeptide alpha	Homo sapiens	152-156
7762663-4	1995	The intragastric capsaicin-induced vasodilation was markedly reversed not only by intravenous administration of the NO synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) but also by submucosal suffusion of either L-NAME or the CGRP receptor antagonist human CGRP-(8-37).	Capsaicin	17-26	calcitonin related polypeptide alpha	Homo sapiens	238-242
7762663-4	1995	The intragastric capsaicin-induced vasodilation was markedly reversed not only by intravenous administration of the NO synthesis inhibitor NG-nitro-L-arginine methyl ester (L-NAME) but also by submucosal suffusion of either L-NAME or the CGRP receptor antagonist human CGRP-(8-37).	Capsaicin	17-26	calcitonin related polypeptide alpha	Homo sapiens	269-273
7741700-11	1995	Capsaicin (10 microM) decreased the content of CGRP-LI in isolated stripped incubated soleus muscle preparations by about 40%.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	47-51
9338085-5	1995	C-fibre polymodal nociceptors activated by interleukin-2 were also activated by subsequent chemical stimuli as follows: 81% were activated by histamine (300 ng/3 microliters), 87% by bradykinin (75 ng/3 microliters), 100% by topical acetic acid and 87% by capsaicin (3 micrograms/3 microliters).	Capsaicin	256-265	interleukin 2	Rattus norvegicus	43-56
7741700-13	1995	Neonatal treatment of rats with capsaicin, which causes de-afferentation of some sensory nerves such, we hypothesize, that CGRP can no longer be released to counteract the effects of insulin in vivo, caused increased rates of glycogen synthesis and increased glycogen content in stripped soleus muscle preparations in vitro when muscles were isolated from the adult rats.	Capsaicin	32-41	calcitonin-related polypeptide alpha	Rattus norvegicus	123-127
7741700-15	1995	These findings support the hypothesis that capsaicin and resiniferatoxin elicit an excitatory response on sensory nerves in skeletal muscle in vitro to cause the efferent release of CGRP.	Capsaicin	43-52	calcitonin-related polypeptide alpha	Rattus norvegicus	182-186
7493604-12	1995	We conclude that allergic and capsaicin-induced cough are modulated by histamine H1 receptor and cholinergic mechanisms.	Capsaicin	30-39	histamine H1 receptor	Cavia porcellus	71-92
7608871-4	1995	Capsaicin induces the release of substance P (SP) by PAFs, producing vasodilation and increasing vascular permeability (neurogenic inflammation).	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	33-44
7608871-4	1995	Capsaicin induces the release of substance P (SP) by PAFs, producing vasodilation and increasing vascular permeability (neurogenic inflammation).	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	46-48
7752061-1	1995	We previously found that capsaicin can dilate third-order arterioles in striated muscle by a mechanism that appears to involve release of endogenous calcitonin gene-related peptide (CGRP).	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	149-180
7752061-1	1995	We previously found that capsaicin can dilate third-order arterioles in striated muscle by a mechanism that appears to involve release of endogenous calcitonin gene-related peptide (CGRP).	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	182-186
7752061-6	1995	Capsaicin in the presence of the specific CGRP receptor antagonist CGRP (8-37) caused an attenuated arteriolar dilation but had no significant venodilatory effect (1A"s 29% +/- 18%, 2A"s 55% +/- 14%, 1V"s 7% +/- 3%, 2V"s 16% +/- 3%).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
7752061-6	1995	Capsaicin in the presence of the specific CGRP receptor antagonist CGRP (8-37) caused an attenuated arteriolar dilation but had no significant venodilatory effect (1A"s 29% +/- 18%, 2A"s 55% +/- 14%, 1V"s 7% +/- 3%, 2V"s 16% +/- 3%).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
7493615-5	1995	Imetit, a new histamine H3 receptor agonist, strongly inhibited the effects of acetylcholine and capsaicin.	Capsaicin	97-106	histamine H3 receptor	Oryctolagus cuniculus	14-35
7885033-1	1995	It has been suggested that capsaicin-induced hyperemia and mucosal protection occurs via calcitonin-gene-related peptide (CGRP) release from gastric afferent sensory neurons and nitric oxide (NO)-mediated vasodilation.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	89-120
7697245-10	1995	The tendency of capsaicin to increase neutrophil elastase in nasal lavage fluid of patients with allergic rhinitis was not observed after treatment with colchicine.	Capsaicin	16-25	elastase, neutrophil expressed	Homo sapiens	38-57
7544421-9	1995	The relaxation was selectively inhibited when endogenous CGRP had been depleted from perivascular nerves by capsaicin (10(-6) M).	Capsaicin	108-117	calcitonin related polypeptide alpha	Homo sapiens	57-61
7780655-0	1995	Suppression by the sumatriptan analogue, CP-122,288 of c-fos immunoreactivity in trigeminal nucleus caudalis induced by intracisternal capsaicin.	Capsaicin	135-144	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
7542231-7	1995	The liberation of endogenous tachykinins by acute tracheal injection of capsaicin was also associated with augmented histamine recovery, which was inhibited by combined NK1- and NK2-receptor blockade.	Capsaicin	72-81	substance-K receptor	Cavia porcellus	178-190
7891139-11	1995	Pretreatment of the rats with chlorisondamine alone or in combination with atropine diminished the capsaicin-induced increase in c-fos, whereas atropine alone was less efficient.	Capsaicin	99-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	129-134
7891139-13	1995	The capsaicin-induced elevation of junB mRNA levels was not influenced by chlorisondamine or atropine alone, whereas both combined potentiated the effect of capsaicin.	Capsaicin	4-13	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-39
7885033-1	1995	It has been suggested that capsaicin-induced hyperemia and mucosal protection occurs via calcitonin-gene-related peptide (CGRP) release from gastric afferent sensory neurons and nitric oxide (NO)-mediated vasodilation.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	122-126
7885033-2	1995	The purpose of this study was to determine whether capsaicin and/or bile acid induced hyperemia is mediated by CGRP and/or NO.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	111-115
7864147-6	1995	Pretreatment with the NK1 receptor antagonist CP-96,345 (4 mg/kg iv), before challenge with substance P, capsaicin, or aerosol hypertonic saline, reduced the amount of neutrophil adhesion by 56%, 93%, and 57% and reduced the amount of eosinophil adhesion by 70%, 83%, and 65%, respectively.	Capsaicin	105-114	tachykinin receptor 1	Rattus norvegicus	22-34
7630485-5	1995	DPDPE ([D-Pen2,5]enkephalin; 1-10 microM), a delta-opioid agonist, also reduced the capsaicin-evoked release in a concentration-dependent manner (approximately 59% reduction).	Capsaicin	84-93	proenkephalin	Rattus norvegicus	17-27
7823672-1	1995	From self-experimentation, I propose that the pain which occurs after application of capsaicin is causalgia and that this "capsaicin causalgia" is due to actual or functional depletion of neuropeptides such as substance P.	Capsaicin	123-132	tachykinin precursor 1	Homo sapiens	210-221
7864125-4	1995	Systemic capsaicin pretreatment (125 mg/kg sc) reduced the antisecretory effects of luminal acid on both TRH analogue- and pentagastrin-stimulated acid secretion.	Capsaicin	9-18	thyrotropin releasing hormone	Rattus norvegicus	105-108
7719401-0	1995	Involvement of capsaicin-sensitive neurons in gastrin release provoked by intragastric administration of bile salts in the rat.	Capsaicin	15-24	gastrin	Rattus norvegicus	46-53
7538136-14	1995	It is concluded that both NK1 and NK2 receptors are involved in the non-cholinergic bronchoconstriction induced by capsaicin or by stimulation of the vagi, although the NK2 receptor contribution is prominent.	Capsaicin	115-124	substance-K receptor	Cavia porcellus	34-46
7719401-7	1995	These findings suggested that the neuronal pathways involved in gastrin release are probably an intragastric local circuit originating from capsaicin-sensitive afferent sensory neurons and terminating in muscarinic receptors in the postsynaptic efferent cholinergic neuron system.	Capsaicin	140-149	gastrin	Rattus norvegicus	64-71
7532951-3	1995	Prolonged repeated applications of capsaicin cream depletes the sensory C-fibers of substance P.	Capsaicin	35-44	tachykinin precursor 1	Homo sapiens	84-95
7739801-1	1995	It has been reported that pituitary adenylate cyclase activating polypeptide (PACAP) is a sensory neuropeptide and that it is contained in capsaicin sensitive fibers.	Capsaicin	139-148	adenylate cyclase activating polypeptide 1	Rattus norvegicus	26-76
7739801-1	1995	It has been reported that pituitary adenylate cyclase activating polypeptide (PACAP) is a sensory neuropeptide and that it is contained in capsaicin sensitive fibers.	Capsaicin	139-148	adenylate cyclase activating polypeptide 1	Rattus norvegicus	78-83
7536950-0	1995	Capsaicin effects on substance P and CGRP in rat adjuvant arthritis.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	37-41
7712013-2	1995	Capsaicin, a selective sensory neurotoxin, was given to newborn rats and at the age of 3 months the contractile activity of the urinary bladder detrusor muscle and vas deferens evoked by either electrical field stimulation (EFS) or exogenous adenosine 5"-triphosphate (ATP) and carbachol (urinary bladder), or ATP and noradrenaline (vas deferens) were tested.	Capsaicin	0-9	arginine vasopressin	Rattus norvegicus	333-336
7712013-13	1995	Contractions of the vas deferens evoked by either ATP (10 micro M-3 mM) or noradrenaline (1-1000 micro M) in the capsaicin-treated group showed no significant difference between control and capsaicin treated rats.6.	Capsaicin	113-122	arginine vasopressin	Rattus norvegicus	20-23
8552780-3	1995	Studies performed in our laboratory add to this evidence by demonstrating that relatively large concentrations of prostaglandins increase SP release, whereas lower amounts augment the capsaicin-stimulated release of both SP and CGRP from rat spinal cord slices.	Capsaicin	184-193	calcitonin-related polypeptide alpha	Rattus norvegicus	228-232
7603300-4	1995	The higher affinity vanilloid receptor, VN1 can be distinguished on the basis of initiating vasoconstriction at low doses of capsaicin and simultaneously stimulating oxygen consumption.	Capsaicin	125-134	vomeronasal 1 receptor 105	Rattus norvegicus	40-43
7746093-7	1995	Recent studies have shown that hepatic cytochrome P450 2E1 catalyzes the conversion of capsaicin to reactive species such as the phenoxy radical intermediate capable of covalently binding to the active site of the enzyme as well as tissue macromolecules.	Capsaicin	87-96	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	39-58
7532083-11	1994	NPY (10(-8) M) completely inhibited the effects of acetylcholine and capsaicin on the Kf,c, without preventing the effects of substance P and 5-HT.	Capsaicin	69-78	neuropeptide Y	Oryctolagus cuniculus	0-3
7884153-5	1994	An intravenous infusion of 2.5 nmol/kg per h of PP and PYY significantly inhibited the pancreatic responses of bile and pancreatic juice diversion in animals with an intact vagal nerve and in those treated with capsaicin, whereas the same dose of peptides failed to inhibit pancreatic secretion in vagotomized rats.	Capsaicin	211-220	pancreatic polypeptide	Rattus norvegicus	48-50
7884153-5	1994	An intravenous infusion of 2.5 nmol/kg per h of PP and PYY significantly inhibited the pancreatic responses of bile and pancreatic juice diversion in animals with an intact vagal nerve and in those treated with capsaicin, whereas the same dose of peptides failed to inhibit pancreatic secretion in vagotomized rats.	Capsaicin	211-220	peptide YY	Rattus norvegicus	55-58
7533802-4	1994	Selective long-term partial depletion of spinal SP and CGRP within small primary afferent nerve fibers including unmyelinated ARN was achieved by intrathecal administration of capsaicin.	Capsaicin	176-185	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
7533802-11	1994	Considering the neurotoxic action of capsaicin for SP-ir and CGRP-ir unmyelinated primary afferent neurons, we hypothesize that spinal SP, CGRP and/or related peptides existing in ARN and other capsaicin-sensitive unmyelinated primary afferent neurons in the lower thoracic spinal cord may ameliorate 1K-WRAP hypertension, but not DOCA hypertension.	Capsaicin	37-46	calcitonin-related polypeptide alpha	Rattus norvegicus	139-143
7533802-11	1994	Considering the neurotoxic action of capsaicin for SP-ir and CGRP-ir unmyelinated primary afferent neurons, we hypothesize that spinal SP, CGRP and/or related peptides existing in ARN and other capsaicin-sensitive unmyelinated primary afferent neurons in the lower thoracic spinal cord may ameliorate 1K-WRAP hypertension, but not DOCA hypertension.	Capsaicin	194-203	calcitonin-related polypeptide alpha	Rattus norvegicus	139-143
7810651-0	1994	Central vagal activation by TRH induces gastric hyperemia: role of CGRP in capsaicin-sensitive afferents in rats.	Capsaicin	75-84	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
7810651-4	1994	In capsaicin-pretreated rats, hCGRP-(8-37) no longer blocked the increase in GMBF induced by intracisternal RX-77368.	Capsaicin	3-12	calcitonin related polypeptide alpha	Homo sapiens	30-35
7810651-5	1994	These results suggest that the gastric hyperemic response to central vagal activation induced by intracisternal TRH analogue at 30 ng is mediated by local effector function of capsaicin-sensitive afferent fibers releasing CGRP.	Capsaicin	176-185	thyrotropin releasing hormone	Rattus norvegicus	112-115
7810651-5	1994	These results suggest that the gastric hyperemic response to central vagal activation induced by intracisternal TRH analogue at 30 ng is mediated by local effector function of capsaicin-sensitive afferent fibers releasing CGRP.	Capsaicin	176-185	calcitonin-related polypeptide alpha	Rattus norvegicus	222-226
7527854-0	1994	Substance P N-terminal metabolites and nitric oxide mediate capsaicin-induced antinociception in the adult mouse.	Capsaicin	60-69	tachykinin 1	Mus musculus	0-11
7527854-1	1994	The present investigation describes the antinociceptive effect of capsaicin in the acetic acid-induced abdominal stretch assay and its mediation by substance P(1-7) fragment [SP(1-7)] and nitric oxide (NO).	Capsaicin	66-75	tachykinin 1	Mus musculus	148-159
7527854-1	1994	The present investigation describes the antinociceptive effect of capsaicin in the acetic acid-induced abdominal stretch assay and its mediation by substance P(1-7) fragment [SP(1-7)] and nitric oxide (NO).	Capsaicin	66-75	sperm autoantigenic protein 17	Mus musculus	175-181
7527854-10	1994	These findings suggest NO is produced and acts within capsaicin-sensitive primary afferent fibers in the dorsal spinal cord to mobilize substance P, resulting in N-terminal induced-antinociception.	Capsaicin	54-63	tachykinin 1	Mus musculus	136-147
7697868-7	1994	The development of capsaicin sensitivity in neural crest cultures was dependent on time in culture and on the presence of NGF.	Capsaicin	19-28	nerve growth factor	Mus musculus	122-125
7532083-19	1994	It was concluded that NPY can protect the lung against acetylcholine- and capsaicin-induced oedemavia a prejunctional modulatory effect on the C-fibres.	Capsaicin	74-83	neuropeptide Y	Oryctolagus cuniculus	22-25
7834212-17	1994	The present findings provide direct electrophysiological evidence for a neurotransmitter role of CGRP, released from the peripheral endings of capsaicin-sensitive primary afferent neurones, in the guinea-pig ureter.	Capsaicin	143-152	calcitonin related polypeptide alpha	Homo sapiens	97-101
7865762-2	1994	The elevation of CGRP release by ACh was absent in capsaicin-desensitized preparations, suggesting that the release of peptide is derived from capsaicin-sensitive afferent nerves.	Capsaicin	143-152	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
7529126-6	1994	Similarly, 10 nM PGI2 did not alter resting release, but augmented capsaicin-stimulated release of SP and CGRP 2-3 fold.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
7522988-3	1994	We administered capsaicin to 44 rats to deplete neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P and administered inert vehicle to 60 control rats.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	70-101
7522988-3	1994	We administered capsaicin to 44 rats to deplete neuropeptides such as calcitonin gene-related peptide (CGRP) and substance P and administered inert vehicle to 60 control rats.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	103-107
7532303-2	1994	Bolus infusion of capsaicin, from 3.5 to 16 nmol, elicited a dose-dependent vasal relaxation effect, which was antagonized by pretreatment with 3 x 10(-6) M calcitonin gene-related peptide (CGRP) (8-37), an antagonist of CGRP.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	157-188
7532303-2	1994	Bolus infusion of capsaicin, from 3.5 to 16 nmol, elicited a dose-dependent vasal relaxation effect, which was antagonized by pretreatment with 3 x 10(-6) M calcitonin gene-related peptide (CGRP) (8-37), an antagonist of CGRP.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	190-194
7532303-2	1994	Bolus infusion of capsaicin, from 3.5 to 16 nmol, elicited a dose-dependent vasal relaxation effect, which was antagonized by pretreatment with 3 x 10(-6) M calcitonin gene-related peptide (CGRP) (8-37), an antagonist of CGRP.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	221-225
7532303-5	1994	The results indicate that in the mesenteric bed, capsaicin-induced vasodilatation is probably independent of the NO-synthesis mechanism and possibly mediated by CGRP.	Capsaicin	49-58	calcitonin-related polypeptide alpha	Rattus norvegicus	161-165
7808222-3	1994	Capsaicin-induced stress caused a rapid and transient induction of NGFI-A, NGFI-B, fra-2 and TIS11 in the hypothalamic paraventricular nucleus.	Capsaicin	0-9	early growth response 1	Rattus norvegicus	67-73
7808222-3	1994	Capsaicin-induced stress caused a rapid and transient induction of NGFI-A, NGFI-B, fra-2 and TIS11 in the hypothalamic paraventricular nucleus.	Capsaicin	0-9	nuclear receptor subfamily 4, group A, member 1	Rattus norvegicus	75-81
7808222-3	1994	Capsaicin-induced stress caused a rapid and transient induction of NGFI-A, NGFI-B, fra-2 and TIS11 in the hypothalamic paraventricular nucleus.	Capsaicin	0-9	FOS like 2, AP-1 transcription factor subunit	Rattus norvegicus	83-88
7808222-3	1994	Capsaicin-induced stress caused a rapid and transient induction of NGFI-A, NGFI-B, fra-2 and TIS11 in the hypothalamic paraventricular nucleus.	Capsaicin	0-9	zinc finger protein 36	Rattus norvegicus	93-98
7915699-4	1994	RESULTS: Lidocaine, hexamethonium, and capsaicin, but not atropine, inhibited toxin A-mediated secretion and MPO activity, but only capsaicin reduced mannitol permeability.	Capsaicin	39-48	myeloperoxidase	Rattus norvegicus	109-112
7915699-6	1994	Toxin A caused release of RMCPII from rat ileum in vivo and in vitro; this was inhibited by lidocaine or capsaicin, whereas cholera toxin had no effect on release of RMCPII.	Capsaicin	105-114	mast cell protease 2	Rattus norvegicus	26-32
7670427-3	1994	Subjects suffering from traumatic dysesthesia of the trigeminal nerve were treated with capsaicin, a substance P depleter with significant long-term effects.	Capsaicin	88-97	tachykinin precursor 1	Homo sapiens	101-112
7823080-0	1994	Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin.	Capsaicin	158-167	tachykinin precursor 1	Homo sapiens	0-18
7823080-0	1994	Neurokinin 1 and 2 antagonists attenuate the responses and NK1 antagonists prevent the sensitization of primate spinothalamic tract neurons after intradermal capsaicin.	Capsaicin	158-167	tachykinin receptor 1	Homo sapiens	59-62
7823080-7	1994	Both NK1 antagonists did, however, produce a significant reduction in the responses of STT neurons to an intradermal injection of capsaicin.	Capsaicin	130-139	tachykinin receptor 1	Homo sapiens	5-8
7823080-8	1994	Finally, despite having no effects on responses to mechanical stimuli, both NK1 antagonists prevented the sensitization of the responses to cutaneous stimuli that is usually observed after intradermal injections of capsaicin.	Capsaicin	215-224	tachykinin receptor 1	Homo sapiens	76-79
7862250-0	1994	Multiple mechanisms for the effects of capsaicin, bradykinin and nicotine on CGRP release from tracheal afferent nerves: role of prostaglandins, sympathetic nerves and mast cells.	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	77-81
7862250-1	1994	Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	129-160
7862250-1	1994	Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	162-166
7862250-1	1994	Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates.	Capsaicin	26-29	calcitonin-related polypeptide alpha	Rattus norvegicus	129-160
7862250-1	1994	Application of capsaicin (CAP), bradykinin (BK) or nicotine (NIC) to intraluminally perfused rat tracheas induced an increase in calcitonin gene-related peptide (CGRP) levels in the perfusates.	Capsaicin	26-29	calcitonin-related polypeptide alpha	Rattus norvegicus	162-166
7952873-22	1994	Activation of both NK1 and NK2receptors contributes to the capsaicin-sensitive responses.	Capsaicin	59-68	tachykinin receptor 1	Homo sapiens	19-22
7847182-3	1994	We also determined the effects of these peptidase inhibitors, and the NK-1 receptor antagonist L-703,606, on the plasma extravasation produced by capsaicin, which releases tachykinins endogenously from sensory nerve endings.	Capsaicin	146-155	tachykinin receptor 1	Rattus norvegicus	70-83
7924160-6	1994	Ablation of the CGRP+ fibres by neonatal treatment with capsaicin resulted in a marked increase in the number of RMCPII+ and RMCPI/II+ cells in lung and, even more, in spleen of adult rats.	Capsaicin	56-65	calcitonin-related polypeptide alpha	Rattus norvegicus	16-20
8048007-0	1994	Capsaicin-induced gastric mucosal hyperemia and protection: the role of calcitonin gene-related peptide.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	72-103
8048007-3	1994	Capsaicin-sensitive neurons store and release calcitonin gene-related peptide (CGRP).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	46-77
8048007-3	1994	Capsaicin-sensitive neurons store and release calcitonin gene-related peptide (CGRP).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
8048007-4	1994	The purpose of this investigation was to study the effects of a CGRP antagonist on capsaicin-induced hyperemia and protection and to determine the role of NO and the cytoprotective prostaglandin PGE2 in this process.	Capsaicin	83-92	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
8048007-11	1994	RESULTS: The CGRP antagonist hCGRP8-37 significantly inhibits capsaicin-induced hyperemia and its associated mucosal cytoprotection and also significantly decreases luminal mucosal PGE2 production.	Capsaicin	62-71	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
8048007-13	1994	CONCLUSIONS: CGRP is a mediator of capsaicin-induced hyperemia and protection.	Capsaicin	35-44	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
8203640-0	1994	Role of peripheral capsaicin-sensitive neurons and CGRP in central vagally mediated gastroprotective effect of TRH.	Capsaicin	19-28	thyrotropin releasing hormone	Rattus norvegicus	111-114
8015106-1	1994	Previous studies have indicated that calcitonin gene-related peptide (CGRP), released from the peripheral endings of capsaicin-sensitive primary afferent neurons, may play a role as an inhibitory transmitter in the guinea pig ureter.	Capsaicin	117-126	calcitonin related polypeptide alpha	Homo sapiens	70-74
8015106-11	1994	In vitro capsaicin pretreatment or administration of the CGRP receptor antagonist reduced the refractory period of the ureter to electrical field stimulation: ITI50 averaged 8.8 and 9.1 seconds after capsaicin or CGRP antagonist pretreatment, respectively.	Capsaicin	9-18	calcitonin related polypeptide alpha	Homo sapiens	213-217
8015106-11	1994	In vitro capsaicin pretreatment or administration of the CGRP receptor antagonist reduced the refractory period of the ureter to electrical field stimulation: ITI50 averaged 8.8 and 9.1 seconds after capsaicin or CGRP antagonist pretreatment, respectively.	Capsaicin	200-209	calcitonin related polypeptide alpha	Homo sapiens	57-61
8015106-12	1994	These findings demonstrate that capsaicin pretreatment or blockade of CGRP receptors produced qualitatively and quantitatively similar excitatory effects on ureteral excitability and refractory period and are in general agreement with the idea that CGRP is a primary inhibitory transmitter in guinea pig ureter.	Capsaicin	32-41	calcitonin related polypeptide alpha	Homo sapiens	70-74
8015106-12	1994	These findings demonstrate that capsaicin pretreatment or blockade of CGRP receptors produced qualitatively and quantitatively similar excitatory effects on ureteral excitability and refractory period and are in general agreement with the idea that CGRP is a primary inhibitory transmitter in guinea pig ureter.	Capsaicin	32-41	calcitonin related polypeptide alpha	Homo sapiens	249-253
7525010-9	1994	These results led us to the understanding of differential action mechanism of NK1-receptor antagonist- and morphine-induced antinociception as assayed by the capsaicin test.	Capsaicin	158-167	tachykinin receptor 1	Homo sapiens	78-90
7521952-0	1994	Stimulation of gastric somatostatin mRNA abundance by substance P in capsaicin-treated rats.	Capsaicin	69-78	somatostatin	Rattus norvegicus	23-35
7521952-5	1994	An increased sensitivity of antral somatostatin cells to substance P may be one of the adaptive changes that occurs in the stomach of capsaicin-treated rats.	Capsaicin	134-143	somatostatin	Rattus norvegicus	35-47
7957631-2	1994	Intraplantar injection of interleukin-1 beta (50 pg) significantly enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram).	Capsaicin	116-125	interleukin 1 beta	Rattus norvegicus	26-44
7957631-3	1994	Pretreatment with a neurotoxic dose of capsaicin reduced the capsaicin-evoked hyperaemia and prevented the facilitatory effect of interleukin-1 beta.	Capsaicin	39-48	interleukin 1 beta	Rattus norvegicus	130-148
7957631-5	1994	These data indicate that the enhancement by interleukin-1 beta of the capsaicin-induced hyperaemia involves thin afferent nerve fibres and depends on nitric oxide as essential intermediate.	Capsaicin	70-79	interleukin 1 beta	Rattus norvegicus	44-62
7955356-3	1994	Treatment of cultures with the capsaicin analog resiniferatoxin (RTX; 0.3-30 nM) significantly augmented CGRP immunoreactivity per neuron at all ages investigated without increasing the number of CGRP-immunoreactive cells.	Capsaicin	31-40	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	105-109
7912896-6	1994	Addition of the sensory neurotoxin, capsaicin (0.01 to 1 microM), to the central compartment caused concentration-dependent release of CGRP; the resultant depletion of sensory transmitter resulted in a concentration-dependent decrease in ascending and descending responses elicited by muscle stretch and mucosal stimulation.	Capsaicin	36-45	calcitonin related polypeptide alpha	Homo sapiens	135-139
8088861-0	1994	Neuropeptide depletion by capsaicin does not prevent mucosal mast cell activation in the rat at weaning.	Capsaicin	26-35	pyroglutamylated RFamide peptide	Rattus norvegicus	0-12
8088861-7	1994	RMCPII levels were similar in capsaicin-treated and control rats and peaked at day 22 of life, and intestinal development was not retarded by capsaicin treatment.	Capsaicin	30-39	mast cell protease 2	Rattus norvegicus	0-6
7524118-1	1994	The aim of this study was to assess the existence of mechanisms regulating the intensity and duration of action of calcitonin gene-related peptide (CGRP), the main candidate inhibitory transmitter released from capsaicin-sensitive afferents in the guinea-pig ureter.	Capsaicin	211-220	calcitonin related polypeptide alpha	Homo sapiens	148-152
7524118-2	1994	In a first series of experiments, performed in capsaicin-pretreated ureters, exogenously administered human alpha CGRP (h alpha CGRP) produced inhibition of contractions of the guinea-pig isolated ureter evoked by direct electrical stimulation of smooth muscle.	Capsaicin	47-56	calcitonin related polypeptide alpha	Homo sapiens	114-118
7524118-2	1994	In a first series of experiments, performed in capsaicin-pretreated ureters, exogenously administered human alpha CGRP (h alpha CGRP) produced inhibition of contractions of the guinea-pig isolated ureter evoked by direct electrical stimulation of smooth muscle.	Capsaicin	47-56	calcitonin related polypeptide alpha	Homo sapiens	128-132
8203640-4	1994	The protective effect of RX-77368 against 60% ethanol was completely abolished by the CGRP monoclonal antibody 4901 (4.8 mg/kg iv), CGRP-(8-37) (128 nmol/kg iv), and capsaicin pretreatment (125 mg/kg).	Capsaicin	166-175	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
8203640-1	1994	We investigated in conscious rats the role of capsaicin-sensitive neurons and alpha-calcitonin gene-related peptide (CGRP), the form preferentially expressed in capsaicin sensory neurons, in mediating intracisternal thyrotropin-releasing hormone (TRH) analogue-induced vagal muscarinic gastroprotection against ethanol lesions.	Capsaicin	161-170	calcitonin-related polypeptide alpha	Rattus norvegicus	117-121
8075827-11	1994	Capsaicin treatment led to a marked depletion of secretoneurin-IR in the substantia gelatinosa, but not in other immunopositive areas of the spinal cord and to a substantial loss of small (< 25 microns) SgII-mRNA-containing dorsal root ganglia neurons.	Capsaicin	0-9	secretogranin II	Rattus norvegicus	206-210
7518811-2	1994	METHODS: Increasing doses of capsaicin from 0.125 to 4 micrograms/cm2 were applied to nonlesional psoriatic skin to establish the minimal dose that induced the substance P-mediated neurogenic response in 30 patients with psoriasis.	Capsaicin	29-38	tachykinin precursor 1	Homo sapiens	160-171
7530074-1	1994	Stimulation of afferent neurons with capsaicin enhanced the glycogen phosphorylase activity and decreased the glycogen contents in the rat liver.	Capsaicin	37-46	glycogen phosphorylase L	Rattus norvegicus	60-82
7520365-3	1994	Increase of salivary SP-LI and CGRP-LI as well as of plasma CGRP-LI occurred after capsaicin stimulation.	Capsaicin	83-92	calcitonin related polypeptide alpha	Homo sapiens	31-35
7520365-3	1994	Increase of salivary SP-LI and CGRP-LI as well as of plasma CGRP-LI occurred after capsaicin stimulation.	Capsaicin	83-92	calcitonin related polypeptide alpha	Homo sapiens	60-64
7513595-7	1994	These data indicate that when capsaicin is presented to the epithelial surface of the lung the resulting airway obstruction is mediated predominantly by NK2 receptor stimulation.	Capsaicin	30-39	substance-K receptor	Cavia porcellus	153-165
7518777-10	1994	We conclude that toluene diisocyanate and capsaicin may produce both shortening and relaxation in isolated human bronchi through NK1 receptors.	Capsaicin	42-51	tachykinin receptor 1	Homo sapiens	129-132
7530074-3	1994	Neurotoxic doses of capsaicin also enhanced the glycogen phosphorylase activity, more obviously so in adult rats.	Capsaicin	20-29	glycogen phosphorylase L	Rattus norvegicus	48-70
8019746-0	1994	Interleukin-1 beta enhances capsaicin-induced neurogenic vasodilatation in the rat skin.	Capsaicin	28-37	interleukin 1 beta	Rattus norvegicus	0-18
8045845-2	1994	After a prolonged exposure to capsaicin, nicotine-induced CGRP release was absent, suggesting that the release of CGRP by nicotine is derived from capsaicin-sensitive afferent terminals.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	58-62
8045845-2	1994	After a prolonged exposure to capsaicin, nicotine-induced CGRP release was absent, suggesting that the release of CGRP by nicotine is derived from capsaicin-sensitive afferent terminals.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	114-118
8045845-2	1994	After a prolonged exposure to capsaicin, nicotine-induced CGRP release was absent, suggesting that the release of CGRP by nicotine is derived from capsaicin-sensitive afferent terminals.	Capsaicin	147-156	calcitonin-related polypeptide alpha	Rattus norvegicus	114-118
8045845-4	1994	The release of CGRP evoked by capsaicin was also reduced after nicotine and cytisine desensitization.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
8015392-9	1994	RBP-26 is expressed in non-neuronal and capsaicin-insensitive neuronal tissues, and shows distinct binding characteristics from the resiniferatoxin binding site defined on DRG membranes.	Capsaicin	40-49	phosphorylated adaptor for RNA export	Rattus norvegicus	0-6
8019746-2	1994	This study examined the effect of interleukin-1 beta (IL-1 beta) on the capsaicin-induced increase in cutaneous blood flow of anaesthetized rats as measured by laser Doppler flowmetry.	Capsaicin	72-81	interleukin 1 beta	Rattus norvegicus	34-52
8019746-2	1994	This study examined the effect of interleukin-1 beta (IL-1 beta) on the capsaicin-induced increase in cutaneous blood flow of anaesthetized rats as measured by laser Doppler flowmetry.	Capsaicin	72-81	interleukin 1 beta	Rattus norvegicus	54-63
8019746-6	1994	IL-1 beta (0.5-500 pg) was without effect on blood flow on its own but dose-dependently enhanced the hyperaemic response to intraplantar capsaicin (0.3 microgram) up to 180% (P < 0.05) of the response seen in saline-treated paws.	Capsaicin	137-146	interleukin 1 beta	Rattus norvegicus	0-9
8019746-11	1994	did not alter the capsaicin-induced vasodilatation but prevented IL-1 beta (50 pg) from augmenting the hyperaemic response to capsaicin.	Capsaicin	126-135	interleukin 1 beta	Rattus norvegicus	65-74
8019746-15	1994	These data indicate that IL-1 beta enhances the cutaneous hyperaemic response to afferent nerve stimulation with capsaicin in a prostaglandin-dependent manner.	Capsaicin	113-122	interleukin 1 beta	Rattus norvegicus	25-34
7513837-0	1994	Endothelin-1 enhances capsaicin-induced peptide release and cGMP accumulation in cultures of rat sensory neurons.	Capsaicin	22-31	endothelin 1	Rattus norvegicus	0-12
8189386-5	1994	The present results showed that the capsaicin desensitized rats had significantly smaller increases in plasma ACTH than the control rats in response to intravenous injection of IL-1 beta or prostaglandin E2.	Capsaicin	36-45	interleukin 1 beta	Rattus norvegicus	177-186
7515383-2	1994	In order to investigate the mechanism of the drug"s action, we evaluated the effect of repeated nasal application of capsaicin on the contents of sensory fibres immunoreactive to substance P and CGRP in the rat nasal mucosa.	Capsaicin	117-126	calcitonin-related polypeptide alpha	Rattus norvegicus	195-199
7515383-7	1994	Capsaicin depletes the fibers immunoreactive to substance P and CGRP in the rat nasal mucosa.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
8189386-9	1994	The capsaicin desensitized rats responded to intravenous injection of corticotrophin releasing factor (CRF) with a greater increase in the plasma level of ACTH than the control rats, indicating that capsaicin pretreatment resulted in augmentation of pituitary gland sensitivity to CRF.	Capsaicin	4-13	corticotropin releasing hormone	Rattus norvegicus	70-101
7513837-2	1994	Although ET-1 had minimal actions on spontaneous neuropeptide release, pretreating cultures with 500 nM resulted in a 50% augmentation of SP and CGRP release evoked by 50 nM capsaicin.	Capsaicin	174-183	endothelin 1	Rattus norvegicus	9-13
8189386-9	1994	The capsaicin desensitized rats responded to intravenous injection of corticotrophin releasing factor (CRF) with a greater increase in the plasma level of ACTH than the control rats, indicating that capsaicin pretreatment resulted in augmentation of pituitary gland sensitivity to CRF.	Capsaicin	199-208	corticotropin releasing hormone	Rattus norvegicus	70-101
7513837-2	1994	Although ET-1 had minimal actions on spontaneous neuropeptide release, pretreating cultures with 500 nM resulted in a 50% augmentation of SP and CGRP release evoked by 50 nM capsaicin.	Capsaicin	174-183	calcitonin-related polypeptide alpha	Rattus norvegicus	145-149
7513837-3	1994	Moreover, 2000 nM ET-1 enhanced capsaicin-evoked release of CGRP two fold.	Capsaicin	32-41	endothelin 1	Rattus norvegicus	18-22
7513837-3	1994	Moreover, 2000 nM ET-1 enhanced capsaicin-evoked release of CGRP two fold.	Capsaicin	32-41	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
7513837-4	1994	In an analogous manner, ET-1 alone did not alter intracellular cGMP content, but enhanced the increase in cGMP caused by 50 nM capsaicin.	Capsaicin	127-136	endothelin 1	Rattus norvegicus	24-28
7507874-2	1994	Mucosal hyperemia, after exposure to capsaicin, is mediated by calcitonin gene-related peptide (CGRP) from these neurons, which also contain substance P (SP).	Capsaicin	37-46	calcitonin-related polypeptide alpha	Rattus norvegicus	63-94
7507874-2	1994	Mucosal hyperemia, after exposure to capsaicin, is mediated by calcitonin gene-related peptide (CGRP) from these neurons, which also contain substance P (SP).	Capsaicin	37-46	calcitonin-related polypeptide alpha	Rattus norvegicus	96-100
7509392-0	1994	An antinociceptive effect of capsaicin in the adult mouse mediated by the NH2-terminus of substance P.	Capsaicin	29-38	tachykinin 1	Mus musculus	90-101
7509392-1	1994	Capsaicin in the adult animal is believed to evoke a massive release of substance P (SP) and a subsequent loss of primary afferent C-fiber activity.	Capsaicin	0-9	tachykinin 1	Mus musculus	72-83
7509392-4	1994	The caudally directed biting and scratching behaviors induced by 1 nmol of capsaicin injected intrathecally were also greatly reduced 24 hr after either 2.6 nmol of capsaicin or 10 nmol of SP(1-7).	Capsaicin	75-84	tachykinin 1	Mus musculus	189-191
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	119-128	tachykinin 1	Mus musculus	55-57
7957539-8	1994	We postulate that tachykinins, such as substance P, play a more important role than prostaglandins in capsaicin-induced cough.	Capsaicin	102-111	tachykinin precursor 1	Homo sapiens	39-50
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	119-128	tachykinin 1	Mus musculus	75-77
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	119-128	tachykinin 1	Mus musculus	75-77
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	119-128	tachykinin 1	Mus musculus	75-77
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	147-156	tachykinin 1	Mus musculus	55-57
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	147-156	tachykinin 1	Mus musculus	75-77
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	147-156	tachykinin 1	Mus musculus	75-77
7509392-5	1994	Pretreatment with an antagonist of the NH2-terminus of SP, [D-Pro2,D-Phe7]-SP(1-7), prevented the long-term effects of capsaicin and of SP(1-7) on capsaicin-induced behaviors in our paradigm at doses that the COOH-terminal antagonist of neurokinin activity, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	147-156	tachykinin 1	Mus musculus	75-77
7509392-6	1994	The antinociceptive effect of capsaicin in the adult animal is, therefore, mimicked by SP(1-7) and attenuated by [D-Pro2,D-Phe7]-SP(1-7), suggesting that the NH2-terminus of SP and its NH2-terminal metabolites, released in response to capsaicin, may contribute to the mediation of capsaicin"s antinociceptive effect.	Capsaicin	30-39	tachykinin 1	Mus musculus	87-89
7509392-6	1994	The antinociceptive effect of capsaicin in the adult animal is, therefore, mimicked by SP(1-7) and attenuated by [D-Pro2,D-Phe7]-SP(1-7), suggesting that the NH2-terminus of SP and its NH2-terminal metabolites, released in response to capsaicin, may contribute to the mediation of capsaicin"s antinociceptive effect.	Capsaicin	30-39	tachykinin 1	Mus musculus	129-131
7509392-6	1994	The antinociceptive effect of capsaicin in the adult animal is, therefore, mimicked by SP(1-7) and attenuated by [D-Pro2,D-Phe7]-SP(1-7), suggesting that the NH2-terminus of SP and its NH2-terminal metabolites, released in response to capsaicin, may contribute to the mediation of capsaicin"s antinociceptive effect.	Capsaicin	30-39	tachykinin 1	Mus musculus	129-131
8297178-4	1994	METHODS: The release of CGRP in response to intragastric and intra-arterial administration of capsaicin in the isolated, vascularly perfused rat stomach was measured by radioimmunoassay.	Capsaicin	94-103	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
8297178-7	1994	RESULTS: Intra-arterial capsaicin (concentration range, 10(-7) to 10(-5) mol/L) stimulated a prompt and sustained release of immunoreactive CGRP, of which 84% coeluted with rat 1-37 CGRP I by gel filtration.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	140-144
8297178-7	1994	RESULTS: Intra-arterial capsaicin (concentration range, 10(-7) to 10(-5) mol/L) stimulated a prompt and sustained release of immunoreactive CGRP, of which 84% coeluted with rat 1-37 CGRP I by gel filtration.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	182-188
7507011-2	1994	Immunohistochemistry showed that administration of capsaicin to newborn rats depleted irreversibly the neuropeptide, substance P. Elimination of capsaicin-sensitive fibres by the neonatal injection of capsaicin did not suppress the peridiscitis of rats in which adjuvant spondylitis was induced at 7 weeks of age.	Capsaicin	51-60	pyroglutamylated RFamide peptide	Rattus norvegicus	103-115
7508205-3	1994	In capsaicin-treated rats (depletor of CGRP and substance P, 50 nmol capsaicin injected intracisternally 24 h before experiment), vasodilatation, which was evoked on transient hypotension, and vasoconstriction on reverse of hypotension were markedly attenuated or almost abolished.	Capsaicin	3-12	calcitonin-related polypeptide alpha	Rattus norvegicus	39-43
7881015-7	1994	In addition, other peripheral mechanisms involve calcitonin gene-related peptide (CGRP) contained in capsaicin sensitive afferent fibres and nitric oxide, both of which mediate the associated increase in GMBF induced by intracisternal injection of RX 77368.	Capsaicin	101-110	calcitonin-related polypeptide alpha	Rattus norvegicus	49-80
7881015-7	1994	In addition, other peripheral mechanisms involve calcitonin gene-related peptide (CGRP) contained in capsaicin sensitive afferent fibres and nitric oxide, both of which mediate the associated increase in GMBF induced by intracisternal injection of RX 77368.	Capsaicin	101-110	calcitonin-related polypeptide alpha	Rattus norvegicus	82-86
7881015-9	1994	Its action is expressed through the muscarinic dependent release of PGE2 and nitric oxide, and efferent function of capsaicin-sensitive afferent fibres releasing CGRP.	Capsaicin	116-125	calcitonin-related polypeptide alpha	Rattus norvegicus	162-166
7507995-0	1994	Role of the NH2-terminus of substance P in the inhibition by capsaicin of behavioral sensitization to kainic acid-induced activity in the adult mouse.	Capsaicin	61-70	tachykinin 1	Mus musculus	28-39
7507995-6	1994	[D-Pro2,D-Phe7]-SP(1-7), a SP NH2-terminal antagonist, injected 5 min before capsaicin or SP(1-7), inhibited the effects of both capsaicin and SP(1-7) on KA sensitization whereas the COOH-terminal neurokinin antagonist, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	129-138	tachykinin 1	Mus musculus	16-18
7507995-6	1994	[D-Pro2,D-Phe7]-SP(1-7), a SP NH2-terminal antagonist, injected 5 min before capsaicin or SP(1-7), inhibited the effects of both capsaicin and SP(1-7) on KA sensitization whereas the COOH-terminal neurokinin antagonist, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	129-138	tachykinin 1	Mus musculus	27-29
7507995-3	1994	In light of our recent observation that the antinociceptive effect of capsaicin may also involve an action of the NH2-terminus of SP, we tested the hypothesis that capsaicin inhibits behavioral sensitization to KA by a desensitization to the action of the NH2-terminus of SP.	Capsaicin	164-173	tachykinin 1	Mus musculus	130-132
7507995-6	1994	[D-Pro2,D-Phe7]-SP(1-7), a SP NH2-terminal antagonist, injected 5 min before capsaicin or SP(1-7), inhibited the effects of both capsaicin and SP(1-7) on KA sensitization whereas the COOH-terminal neurokinin antagonist, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	129-138	tachykinin 1	Mus musculus	27-29
7507995-6	1994	[D-Pro2,D-Phe7]-SP(1-7), a SP NH2-terminal antagonist, injected 5 min before capsaicin or SP(1-7), inhibited the effects of both capsaicin and SP(1-7) on KA sensitization whereas the COOH-terminal neurokinin antagonist, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	129-138	tachykinin 1	Mus musculus	27-29
8107527-4	1994	Moreover, pretreatment with capsaicin is able to mimic the anti-inflammatory effect of exogenous CGRP, while simultaneous administration of CGRP and capsaicin produces a reduced response.	Capsaicin	28-37	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	97-101
7507995-6	1994	[D-Pro2,D-Phe7]-SP(1-7), a SP NH2-terminal antagonist, injected 5 min before capsaicin or SP(1-7), inhibited the effects of both capsaicin and SP(1-7) on KA sensitization whereas the COOH-terminal neurokinin antagonist, [D-Pro2,D-Trp7,9]-SP, did not.	Capsaicin	129-138	tachykinin 1	Mus musculus	27-29
7507995-7	1994	The similarities in behavioral responses after treatment with SP(1-7) or capsaicin, together with the sensitivity of these effects to D-SP(1-7), suggest that SP released in response to capsaicin may inhibit subsequent KA-induced activity 24 hr later.	Capsaicin	185-194	tachykinin 1	Mus musculus	62-64
7507995-7	1994	The similarities in behavioral responses after treatment with SP(1-7) or capsaicin, together with the sensitivity of these effects to D-SP(1-7), suggest that SP released in response to capsaicin may inhibit subsequent KA-induced activity 24 hr later.	Capsaicin	185-194	tachykinin 1	Mus musculus	136-138
7507995-7	1994	The similarities in behavioral responses after treatment with SP(1-7) or capsaicin, together with the sensitivity of these effects to D-SP(1-7), suggest that SP released in response to capsaicin may inhibit subsequent KA-induced activity 24 hr later.	Capsaicin	185-194	tachykinin 1	Mus musculus	136-138
7507995-8	1994	This action of SP appears to be brought about by its NH2-terminus and/or an accumulation of its NH2-terminal metabolites after capsaicin treatment.	Capsaicin	127-136	tachykinin 1	Mus musculus	15-17
7516558-6	1994	The density of [125I]CGRP binding sites on the epithelium, but not blood vessels, was increased (p < 0.05) by 22% after chronic capsaicin pretreatment, suggesting receptor upregulation.	Capsaicin	131-140	calcitonin-related polypeptide alpha	Rattus norvegicus	21-25
8301598-11	1994	Moreover, RTX and capsaicin both release tachykinins that act on both NK-1 and NK-2 receptor subtypes.	Capsaicin	18-27	substance-K receptor	Cavia porcellus	79-92
8119315-0	1993	Secretin inhibits gastric emptying in rats via a capsaicin-sensitive vagal afferent pathway.	Capsaicin	49-58	secretin	Rattus norvegicus	0-8
7778409-6	1994	In adult rats that had been treated neonatally with capsaicin, there was a marked fall in c-fos activation by mechanical or chemical noxious stimuli in all immunoreactive areas.	Capsaicin	52-61	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	90-95
8279555-4	1993	However, permanent destruction of primary sensory afferent nerves by neonatal treatment of rats with capsaicin reduced the mucin response to CT to baseline levels in both regions.	Capsaicin	101-110	solute carrier family 13 member 2	Rattus norvegicus	123-128
8279555-7	1993	These results suggest that choleraic mucin secretion is mediated primarily by a capsaicin-sensitive neurogenic pathway involving local activation of sensory nerves, which may then elicit mucin secretion through interaction with cholinergic nerves.	Capsaicin	80-89	solute carrier family 13 member 2	Rattus norvegicus	37-42
8279555-7	1993	These results suggest that choleraic mucin secretion is mediated primarily by a capsaicin-sensitive neurogenic pathway involving local activation of sensory nerves, which may then elicit mucin secretion through interaction with cholinergic nerves.	Capsaicin	80-89	solute carrier family 13 member 2	Rattus norvegicus	187-192
8303215-7	1993	These findings suggest that 96% ethanol induced a decrease of CGRP-li deriving from a capsaicin-sensitive pool and that CGRP may play a role in gastric ulcer pathogenesis of haemorrhagic lesions induced by concentrated ethanol.	Capsaicin	86-95	calcitonin-related polypeptide alpha	Rattus norvegicus	62-66
8010084-0	1994	Topical capsaicin treatment suppresses formalin-induced fos expression in rat spinal cord.	Capsaicin	8-17	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
7508328-15	1993	Neuropeptides (1-100 pmol per site) such as rat calcitonin gene-related peptide (CGRP), SP, neurokinin A (NKA), and vasoactive intestinal peptide (VIP), which are released from capsaicin-sensitive neurones, caused ear oedema by intradermal injection.	Capsaicin	177-186	calcitonin-related polypeptide alpha	Rattus norvegicus	48-79
7508328-15	1993	Neuropeptides (1-100 pmol per site) such as rat calcitonin gene-related peptide (CGRP), SP, neurokinin A (NKA), and vasoactive intestinal peptide (VIP), which are released from capsaicin-sensitive neurones, caused ear oedema by intradermal injection.	Capsaicin	177-186	vasoactive intestinal peptide	Rattus norvegicus	116-145
7508577-6	1993	Additional PACAP-immunoreactive fibres not associated with epithelia seemed to lack calcitonin gene-related peptide and substance P. Capsaicin treatment reduced the density of PACAP- and calcitonin gene-related peptide/substance P-immunoreactive fibres in the tissues examined.	Capsaicin	133-142	adenylate cyclase activating polypeptide 1	Rattus norvegicus	11-16
7508577-6	1993	Additional PACAP-immunoreactive fibres not associated with epithelia seemed to lack calcitonin gene-related peptide and substance P. Capsaicin treatment reduced the density of PACAP- and calcitonin gene-related peptide/substance P-immunoreactive fibres in the tissues examined.	Capsaicin	133-142	adenylate cyclase activating polypeptide 1	Rattus norvegicus	176-181
8303215-5	1993	Pretreatment with the selective sensory neurotoxin capsaicin induced a gastric CGRP-li decrease in the corpus and forestomach.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
8119315-3	1993	Functional ablation of vagal, but not spinal, capsaicin-sensitive afferents reversed the action of secretin by 61%.	Capsaicin	46-55	secretin	Rattus norvegicus	99-107
8119320-0	1993	A monoclonal antibody to calcitonin gene-related peptide abolishes capsaicin-induced gastroprotection.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	25-56
8119320-1	1993	Calcitonin gene-related peptide (CGRP) released from vasodilator nerves is implicated in the gastroprotective action of capsaicin.	Capsaicin	120-129	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
8119320-1	1993	Calcitonin gene-related peptide (CGRP) released from vasodilator nerves is implicated in the gastroprotective action of capsaicin.	Capsaicin	120-129	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
8119320-4	1993	The protective effect of capsaicin was abolished by close arterial administration of the anti-CGRP antibody #4901 (5 mg) to the stomach.	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	94-98
8119320-6	1993	These data establish anti-CGRP antibody #4901 as a tool to neutralize endogenously released CGRP and show that CGRP is indispensable for the gastroprotective action of capsaicin.	Capsaicin	168-177	calcitonin-related polypeptide alpha	Rattus norvegicus	26-30
7507780-14	1993	Pretreatment of tissues for 1 h with capsaicin (10 microM), which depletes different sensory neurones, produced a small, but significant, inhibitory effect on ET-1 concentration-response curves in the presence but not the absence of the epithelium.	Capsaicin	37-46	endothelin-1	Cavia porcellus	159-163
7693010-1	1993	Capsaicin in the adult animal causes antinociception due to the massive release of neurotransmitters, including substance P (SP), from primary afferent C-fibers.	Capsaicin	0-9	tachykinin 1	Mus musculus	112-123
7905345-8	1993	A cross-tachyphylaxis between capsaicin (1 microM) and CGRP (1 microM) was observed.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
7905345-9	1993	Both capsaicin and CGRP-induced relaxation were partially antagonized by the proposed CGRP antagonist, CGRP (8-37) (10 microM).	Capsaicin	5-14	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
7905345-9	1993	Both capsaicin and CGRP-induced relaxation were partially antagonized by the proposed CGRP antagonist, CGRP (8-37) (10 microM).	Capsaicin	5-14	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
7905345-13	1993	A cross-tachyphylaxis between capsaicin and CGRP was observed.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
7504792-0	1993	Distribution and binding sites of substance P and calcitonin gene-related peptide and their capsaicin-sensitivity in the spinal cord of rats and chicken: a comparative study.	Capsaicin	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	50-81
7504792-4	1993	Neonatal capsaicin pretreatment, that reduced SP and CGRP immunoreactivities, increased SP specific binding sites in laminae I-III and X by 20 and 100%, respectively.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	53-57
7504792-10	1993	The data demonstrated a different action of capsaicin on SP and CGRP and their specific binding sites in the spinal cord of rats and chicken and were discussed with regard to functional differences between these two animal species.	Capsaicin	44-53	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
7693493-8	1993	However, when NK2 receptor antagonists were combined with CP-96,345, the incidence of dyspnea induced by capsaicin decreased significantly (40%) suggesting that both tachykinins contribute to dyspnea in this system.	Capsaicin	105-114	substance-K receptor	Cavia porcellus	14-26
7905345-0	1993	Capsaicin-induced relaxation in the rat isolated external urethral sphincter: characterization of the vanilloid receptor and mediation by CGRP.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	138-142
7905345-7	1993	Capsaicin-induced relaxation of NA-precontracted REUS was mimicked by calcitonin gene-related peptide (CGRP, 0.3-10 microM), but not by substance P (1 microM), vasoactive intestinal polypeptide (VIP, 1 microM), alpha-beta methylene ATP (10 microM), gamma-aminobutyric acid (GABA, 3 mM) or galanin (1 microM).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	70-101
7905345-7	1993	Capsaicin-induced relaxation of NA-precontracted REUS was mimicked by calcitonin gene-related peptide (CGRP, 0.3-10 microM), but not by substance P (1 microM), vasoactive intestinal polypeptide (VIP, 1 microM), alpha-beta methylene ATP (10 microM), gamma-aminobutyric acid (GABA, 3 mM) or galanin (1 microM).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	103-107
7905345-7	1993	Capsaicin-induced relaxation of NA-precontracted REUS was mimicked by calcitonin gene-related peptide (CGRP, 0.3-10 microM), but not by substance P (1 microM), vasoactive intestinal polypeptide (VIP, 1 microM), alpha-beta methylene ATP (10 microM), gamma-aminobutyric acid (GABA, 3 mM) or galanin (1 microM).	Capsaicin	0-9	vasoactive intestinal peptide	Rattus norvegicus	195-208
8246148-0	1993	Competitive inhibition by capsazepine of [3H]resiniferatoxin binding to central (spinal cord and dorsal root ganglia) and peripheral (urinary bladder and airways) vanilloid (capsaicin) receptors in the rat.	Capsaicin	174-183	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	163-173
8238428-2	1993	We examined effects of topically applied capsaicin on arteriolar diameter in striated muscle and tested the hypothesis that capsaicin can alter microvascular tone by releasing substance P (SP) or calcitonin gene-related peptide (CGRP).	Capsaicin	124-133	calcitonin-related polypeptide alpha	Rattus norvegicus	196-227
8238428-2	1993	We examined effects of topically applied capsaicin on arteriolar diameter in striated muscle and tested the hypothesis that capsaicin can alter microvascular tone by releasing substance P (SP) or calcitonin gene-related peptide (CGRP).	Capsaicin	124-133	calcitonin-related polypeptide alpha	Rattus norvegicus	229-233
8238428-9	1993	Pretreatment with a CGRP inhibitor to the bath prevented capsaicin-induced dilation, but not constriction.	Capsaicin	57-66	calcitonin-related polypeptide alpha	Rattus norvegicus	20-24
8238428-10	1993	These results suggest that capsaicin can dilate microvessels by releasing CGRP, which can modulate tone.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
7508508-11	1993	The effects of capsaicin were reduced by desensitization with senktide analogue at a concentration selective for the NK-3 receptor subtype, whereas a non-peptide NK-1 receptor antagonist had no effect.	Capsaicin	15-24	neuromedin-K receptor	Cavia porcellus	117-130
7693010-1	1993	Capsaicin in the adult animal causes antinociception due to the massive release of neurotransmitters, including substance P (SP), from primary afferent C-fibers.	Capsaicin	0-9	tachykinin 1	Mus musculus	125-127
7692552-0	1993	The effects of NK-1 and NK-2 receptor antagonists on the capsaicin evoked synaptic response in the rat spinal cord in vitro.	Capsaicin	57-66	tachykinin receptor 2	Rattus norvegicus	24-37
7688774-2	1993	OBJECTIVE: Safety and efficacy of topical capsaicin, a potent substance P depletor, were evaluated in patients with pruritic psoriasis.	Capsaicin	42-51	tachykinin precursor 1	Homo sapiens	62-73
7688774-7	1993	CONCLUSION: Topically applied capsaicin effectively treats pruritic psoriasis, a finding that supports a role for substance P in this disorder.	Capsaicin	30-39	tachykinin precursor 1	Homo sapiens	114-125
7693075-8	1993	These data support the hypothesis that substances whose degradation is inhibited by combined NEP and ACE inhibitors contribute to the bronchoconstriction induced by iv administered capsaicin.	Capsaicin	181-190	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	101-104
8210518-2	1993	More recently, both functional and neurochemical evidence have been accumulated that BK evokes release of neuropeptides, including calcitonin gene-related peptide and the tachykinins substance P and neurokinin A, from peripheral terminals of capsaicin-sensitive primary afferents.	Capsaicin	242-251	kininogen 1	Homo sapiens	85-87
8103634-6	1993	In separate studies, we demonstrated that perivagal treatment with the sensory neurotoxin capsaicin impaired pancreatic responses to CCK-8 but had no effect on the inhibitory action of somatostatin-14 on pancreatic secretion evoked by 2-deoxy-D-glucose, ruling out an effect of somatostatin on the vagal afferent pathway.	Capsaicin	90-99	somatostatin	Rattus norvegicus	278-290
7692555-0	1993	The amino-terminus of substance P mimics and MK-801 attenuates the effects of capsaicin on nociception and kainic acid-induced behavior in the mouse.	Capsaicin	78-87	tachykinin 1	Mus musculus	22-33
8350386-0	1993	110/140 laminin-binding protein immunoreactivity in spinal dorsal root ganglia: a capsaicin-insensitive reduction induced by constriction injury of the sciatic nerve in rats.	Capsaicin	82-91	galectin 3	Rattus norvegicus	8-31
8100836-6	1993	Similarly perivagal treatment with a sensory neurotoxin, capsaicin, caused a complete inhibition of pancreatic protein secretion in response to CCK-8 infusion.	Capsaicin	57-66	cholecystokinin	Rattus norvegicus	144-147
8100836-9	1993	In conclusion, CCK at physiological levels stimulates pancreatic enzyme secretion via a capsaicin-sensitive afferent vagal pathway originating from the gastroduodenal mucosa.	Capsaicin	88-97	cholecystokinin	Rattus norvegicus	15-18
8367613-6	1993	In both species, initial capsaicin injections (CAP1) caused a long latency (time to peak heart rate 26.8 +/- 2 and 20 sec +/- 2.5) increase in heart rate (40% +/- 11 and 20.1% +/- 8.2 for the newborn dog and pig respectively).	Capsaicin	25-34	adenylyl cyclase-associated protein 1	Canis lupus familiaris	47-51
8367613-7	1993	In the dog, but not the pig, capsaicin responses after the ACh trial (CAP2 and CAP3) caused a short latency bradycardia while the long latency tachycardia continued to be expressed in both species.	Capsaicin	29-38	cyclase associated actin cytoskeleton regulatory protein 2	Sus scrofa	70-74
8338172-8	1993	Substance P and human calcitonin gene-related peptide II dilated arterioles; these dilations were not inhibited after desensitization of the capsaicin-induced vasodilation.	Capsaicin	141-150	tachykinin precursor 1	Homo sapiens	0-11
8101362-5	1993	Selective neurokinin-1 receptor antagonists blocked the chemonociceptive reflex produced by topical application of capsaicin with the rank order of potency (lowest effective dose in brackets): GR 82,334 (1 nmol/rat) > RP 67,580 (10 nmol/rat) > (+/-)CP 96,345 (100 nmol/rat).	Capsaicin	115-124	tachykinin receptor 1	Rattus norvegicus	10-31
8358055-5	1993	Sensory neuropeptides such as calcitonin gene-related peptide (CGRP) may also play a local protective role, since acute intragastric administration of capsaicin which stimulates neuropeptide release, protects against mucosal injury induced by ET-1, as does local infusion of CGRP.	Capsaicin	151-160	calcitonin related polypeptide alpha	Homo sapiens	30-61
8358055-5	1993	Sensory neuropeptides such as calcitonin gene-related peptide (CGRP) may also play a local protective role, since acute intragastric administration of capsaicin which stimulates neuropeptide release, protects against mucosal injury induced by ET-1, as does local infusion of CGRP.	Capsaicin	151-160	calcitonin related polypeptide alpha	Homo sapiens	63-67
8358055-5	1993	Sensory neuropeptides such as calcitonin gene-related peptide (CGRP) may also play a local protective role, since acute intragastric administration of capsaicin which stimulates neuropeptide release, protects against mucosal injury induced by ET-1, as does local infusion of CGRP.	Capsaicin	151-160	endothelin 1	Homo sapiens	243-247
8358055-5	1993	Sensory neuropeptides such as calcitonin gene-related peptide (CGRP) may also play a local protective role, since acute intragastric administration of capsaicin which stimulates neuropeptide release, protects against mucosal injury induced by ET-1, as does local infusion of CGRP.	Capsaicin	151-160	calcitonin related polypeptide alpha	Homo sapiens	275-279
8358055-6	1993	Furthermore, chronic administration of capsaicin which deplete primary sensory neurones augments gastric damage induced by a number of ulcerogens including ET-1.	Capsaicin	39-48	endothelin 1	Homo sapiens	156-160
7690431-0	1993	Involvement of CGRP, substance P and blood circulation in aggravating mechanism of absolute ethanol-induced antral lesions by capsaicin treatment in rats.	Capsaicin	126-135	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
7690431-6	1993	Capsaicin-treatment significantly decreased CGRP- and Sub P-immunoreactive substances in the vascular smooth muscle in the antrum, but not in the corpus.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
7690431-8	1993	From the above results, it was suggested that capsaicin-treatment decreased the gastroprotective ability in the antrum to a greater extent than in the corpus and this may be caused by the decrease of GMBF through the decrease of CGRP- and Sub P-immunoreactive substances.	Capsaicin	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	229-233
8392482-6	1993	Furthermore, it was suggested that CGRP and galanin probably act on the capsaicin-sensitive primary afferents to increase the activated release of endogenous SP from their terminals, and consequently, processing of nociceptive information induced by mechanical stimulation of the periphery is enhanced in the spinal dorsal horn.	Capsaicin	72-81	calcitonin-related polypeptide alpha	Rattus norvegicus	35-39
7686493-0	1993	Effects of an NK1 receptor antagonist, FK888, on constriction and plasma extravasation induced in guinea pig airway by neurokinins and capsaicin.	Capsaicin	135-144	substance-P receptor	Cavia porcellus	14-26
7684305-19	1993	The foregoing results demonstrate that the non-peptide NK1-receptor antagonist, RP67580, is a potent inhibitor of plasma extravasation induced in skin by NK1-receptor agonists, by local application of chemical irritants (capsaicin or xylene) or by electrical nerve stimulation.	Capsaicin	221-230	tachykinin receptor 1	Rattus norvegicus	55-67
8396057-4	1993	There is now evidence that in addition to sympathetic and parasympathetic innervation capsaicin-sensitive sensory nerves contribute to the local control of atrial contractility by releasing NANC transmitters, such as calcitonin gene-related peptide (CGRP).	Capsaicin	86-95	calcitonin related polypeptide alpha	Homo sapiens	217-248
8396057-4	1993	There is now evidence that in addition to sympathetic and parasympathetic innervation capsaicin-sensitive sensory nerves contribute to the local control of atrial contractility by releasing NANC transmitters, such as calcitonin gene-related peptide (CGRP).	Capsaicin	86-95	calcitonin related polypeptide alpha	Homo sapiens	250-254
8478685-6	1993	5-HT at 10(-4) M had no effect upon the resting efflux of CGRP, but at a concentration of 10(-6) M significantly enhanced the release of CGRP evoked by capsaicin (10(-6) M).	Capsaicin	152-161	calcitonin-related polypeptide alpha	Rattus norvegicus	137-141
7682823-13	1993	Injection of capsaicin (150 micrograms/kg intravenously), a substance known to degranulate epithelial serous cells, reduced the staining of the serous cells for CGRP.	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	161-165
8097875-10	1993	We conclude that the mechanism of neurotensin stimulation is indirect and neurally mediated and involves nicotinic and muscarinic synapses, CCKA receptors, and, in part, capsaicin-sensitive sensory fibers.	Capsaicin	170-179	neurotensin	Rattus norvegicus	34-45
8476064-5	1993	Capsaicin, a stimulant of nociceptive sensory nerves, stimulated GRP release into nasal secretions.	Capsaicin	0-9	gastrin-releasing peptide	Cavia porcellus	65-68
7685398-9	1993	In neonatal capsaicin-treated rats, there was a 10% reduction in neurons expressing NPY mRNA, a 37% reduction for VIP, and a 27% for GAL mRNA compared to vehicle-treated rats after nerve cut.	Capsaicin	12-21	neuropeptide Y	Rattus norvegicus	84-87
7685398-9	1993	In neonatal capsaicin-treated rats, there was a 10% reduction in neurons expressing NPY mRNA, a 37% reduction for VIP, and a 27% for GAL mRNA compared to vehicle-treated rats after nerve cut.	Capsaicin	12-21	vasoactive intestinal peptide	Rattus norvegicus	114-117
7685398-9	1993	In neonatal capsaicin-treated rats, there was a 10% reduction in neurons expressing NPY mRNA, a 37% reduction for VIP, and a 27% for GAL mRNA compared to vehicle-treated rats after nerve cut.	Capsaicin	12-21	galanin and GMAP prepropeptide	Rattus norvegicus	133-136
7685398-10	1993	Capsaicin-sensitive neurons comprised 37% of CGRP neurons and 83% of SOM neurons.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	45-49
7685398-10	1993	Capsaicin-sensitive neurons comprised 37% of CGRP neurons and 83% of SOM neurons.	Capsaicin	0-9	somatostatin	Rattus norvegicus	69-72
8495452-1	1993	It has been suggested that treatment of cluster headache (CH) patients with topical capsaicin may desensitize sensory neurons by depleting the nerve terminals of substance P.	Capsaicin	84-93	tachykinin precursor 1	Homo sapiens	162-173
7683473-0	1993	Neonatal capsaicin exposure affects isolation-induced aggressive behavior and hypothalamic substance P levels of adult male mice (Mus musculus).	Capsaicin	9-18	tachykinin 1	Mus musculus	91-102
7683473-1	1993	Subcutaneous administration of capsaicin (50 mg/kg) at Postnatal Days 2 and 5 exerted long-term effects on isolation-induced aggressive behavior of adult mice (Mus musculus) of the CD-1 strain.	Capsaicin	31-40	CD1 antigen complex	Mus musculus	181-185
7683473-4	1993	Capsaicin treatment significantly lowered hypothalamic SP content in both isolated and nonisolated mice.	Capsaicin	0-9	tachykinin 1	Mus musculus	55-57
7683473-5	1993	Moreover, individual scores of isolated capsaicin-treated subjects showed a significant correlation between SP depletion and expression of offensive upright posture.	Capsaicin	40-49	tachykinin 1	Mus musculus	108-110
7682611-1	1993	Behavioral sensitization to kainic acid (KA) in the mouse spinal cord appears to be mediated by the amino (N) terminus of substance P (SP), as potentiation of KA is sensitive to capsaicin, mimicked by SP1-7 but not SP5-11, and blocked by SP1-7 antagonists but not by neurokinin antagonists.	Capsaicin	178-187	tachykinin 1	Mus musculus	122-133
7682749-4	1993	At the highest capsaicin dose used, there was, in addition, a marked increase in arterial levels of calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (LI).	Capsaicin	15-24	Calcitonin gene-related peptide	Sus scrofa	100-131
8387220-0	1993	Capsaicin induced afferent denervation and receptor-linked responses to CGRP in the rat.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	72-76
8387220-1	1993	We have examined the effect of neonatal capsaicin-induced destruction of primary afferent nerves in rats on the response to calcitonin gene-related peptide (CGRP) in vitro and in vivo.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	124-155
8387220-1	1993	We have examined the effect of neonatal capsaicin-induced destruction of primary afferent nerves in rats on the response to calcitonin gene-related peptide (CGRP) in vitro and in vivo.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	157-161
7682749-4	1993	At the highest capsaicin dose used, there was, in addition, a marked increase in arterial levels of calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (LI).	Capsaicin	15-24	Calcitonin gene-related peptide	Sus scrofa	133-137
7682749-4	1993	At the highest capsaicin dose used, there was, in addition, a marked increase in arterial levels of calcitonin gene-related peptide (CGRP)- and neuropeptide Y (NPY)-like immunoreactivity (LI).	Capsaicin	15-24	neuropeptide Y	Sus scrofa	144-158
7682749-7	1993	It is concluded that capsaicin given intravenously to the pig produces profound haemodynamic effects and release of CGRP- and NPY-LI through direct activation of a population of C-fibre endings and increased autonomic discharge.	Capsaicin	21-30	Calcitonin gene-related peptide	Sus scrofa	116-120
8453173-10	1993	Capsaicin as a pure white crystalline material, however, acts specifically by depleting stores of substance P from sensory neurons, and has been successful in the treatment of several painful conditions (e.g., rheumatoid arthritis, osteoarthritis, peripheral neuropathies.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	98-109
8483803-0	1993	The effects of neonatal capsaicin on plasma levels and tissue contents of CGRP.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
7683402-3	1993	The addition of CAP (10 microM) to the perfusate had no effect upon resting VIP release, but elevated CGRP and SP release significantly by 11.1 +/- 0.8 and 0.19 +/- 0.03 pg/mg/min over baseline release rate, respectively.	Capsaicin	16-19	calcitonin-related polypeptide alpha	Rattus norvegicus	102-106
7683402-8	1993	These data suggest that the afferent-evoked release of SP and CGRP from CAP-sensitive terminals (presumably those associated with small primary afferents) is modulated by local alpha 2 receptors.	Capsaicin	72-75	calcitonin-related polypeptide alpha	Rattus norvegicus	62-66
8483803-4	1993	Plasma IR-CGRP levels were also significantly lower in the capsaicin-treated rats throughout their life span (p < 0.001), suggesting that, at least in part, circulating CGRP is derived from the nervous system.	Capsaicin	59-68	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
8483803-4	1993	Plasma IR-CGRP levels were also significantly lower in the capsaicin-treated rats throughout their life span (p < 0.001), suggesting that, at least in part, circulating CGRP is derived from the nervous system.	Capsaicin	59-68	calcitonin-related polypeptide alpha	Rattus norvegicus	172-176
8093880-0	1993	Calcitonin gene-related peptide mediates capsaicin-induced neuroendocrine responses in rat antrum.	Capsaicin	41-50	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
8447372-6	1993	Capsaicin, which induces release of CGRP from sensory nerve endings, was found to exert similar effects on Na(+)-K+ transport.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	36-40
8443037-8	1993	Thus, neurotransmitters in the central nervous system which are substrate for MAO-A (i.e. noradrenaline, 5-HT) may be involved in the control of capsaicin-induced reflex bronchoconstriction.	Capsaicin	145-154	monoamine oxidase A	Homo sapiens	78-83
8093880-6	1993	RESULTS: Capsaicin, like exogenous CGRP, stimulated antral somatostatin release and inhibited both gastrin release and acetylcholine discharge.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	35-39
8093880-6	1993	RESULTS: Capsaicin, like exogenous CGRP, stimulated antral somatostatin release and inhibited both gastrin release and acetylcholine discharge.	Capsaicin	9-18	gastrin	Rattus norvegicus	99-106
8093880-7	1993	Low dose capsaicin (1 x 10(-5) mol/L) caused significant stimulation of CGRP release: 33 +/- 0.2 vs. 14 +/- 1 pg/mL protein; P < 0.001.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	72-76
8093880-8	1993	Tetrodotoxin blocked capsaicin-induced inhibition of acetylcholine release and prevented partially capsaicin-mediated stimulation of CGRP release.	Capsaicin	99-108	calcitonin-related polypeptide alpha	Rattus norvegicus	133-137
8093880-9	1993	The CGRP receptor antagonist CGRP8-37 prevented capsaicin-induced D-cell stimulation and inhibition of G-cell secretion and cholinergic discharge.	Capsaicin	48-57	calcitonin-related polypeptide alpha	Rattus norvegicus	4-8
8093880-10	1993	CONCLUSIONS: The effects of capsaicin-induced changes in antral D- and G-cell secretion and acetylcholine discharge are due primarily to release of CGRP.	Capsaicin	28-37	calcitonin-related polypeptide alpha	Rattus norvegicus	148-152
8430899-7	1993	The treatment with capsaicin in the neonatal period led to a marked depletion of CGRP-immunoreactivity in these extrinsic nerves as well as in the most terminal varicose fibres seen in the whole layers of the rectal wall.	Capsaicin	19-28	calcitonin-related polypeptide alpha	Rattus norvegicus	81-85
8435758-3	1993	Capsaicin pretreatment did not influence c-fos-immunoreactivity induced by bombesin and significantly reduced that induced by CCK.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	126-129
7680798-4	1993	Dorsal horn neurons activated by the capsaicin-evoked input were also excited by a 1-min perfusion of the neurokinin-1 receptor agonists substance P methyl ester or GR73 632 and by the neurokinin-2 agonist neurokinin-A.	Capsaicin	37-46	tachykinin receptor 1	Rattus norvegicus	106-127
8317313-3	1993	Capsaicin (100 nmol/site) and human alpha CGRP (3 pmol/site) stimulated similar increases in blood flow and, in both cases, the effect was totally abolished by the CGRP antagonist, CGRP8-37 (1 nmol/site).	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	164-168
8317313-6	1993	In addition, however, they suggest that nitric oxide is required for either the release of endogenous CGRP from capsaicin-sensitive nerves or its subsequent activity.	Capsaicin	112-121	calcitonin related polypeptide alpha	Homo sapiens	102-106
7679029-7	1993	The relaxant responses to capsaicin were blocked in a selective manner by ruthenium red (3 microM) and by the CGRP antagonist, CGRP8-37 (1 microM).	Capsaicin	26-35	calcitonin related polypeptide alpha	Homo sapiens	110-114
7679029-19	1993	These results suggest that capsaicin causes relaxation of GPBA via a release of CGRP.	Capsaicin	27-36	calcitonin related polypeptide alpha	Homo sapiens	80-84
8093704-5	1993	In contrast, in rats treated with capsaicin to lesion small diameter afferents there was a significant decrease in somatostatin mRNA abundance in the corpus but not antrum.	Capsaicin	34-43	somatostatin	Rattus norvegicus	115-127
8101496-4	1993	A mechanism of this reflex descending inhibition of cholinergic transmission is realised apparently through the stimulation of the chemoreceptors in afferent capsaicin-sensitive nerves with participation of cholinergic interneurons and activation of the inhibitory, most probably vasoactive intestinal peptidergic (VIP) neurons in the enteric plexuses.	Capsaicin	158-167	VIP peptides	Cavia porcellus	315-318
7904285-0	1993	Calcitonin gene-related peptide: a neurotransmitter involved in capsaicin-sensitive afferent nerve-mediated gastric mucosal protection.	Capsaicin	64-73	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
7904285-8	1993	Pretreatment with a CGRP antagonist abolished the protective action of intragastric capsaicin against damaging agents.	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	20-24
8093704-7	1993	Gastric capsaicin-sensitive afferents are rich in calcitonin gene-related peptide, and in rats with antibodies to this peptide there was reduced corpus somatostatin mRNA.	Capsaicin	8-17	somatostatin	Rattus norvegicus	152-164
7904285-9	1993	In isolated perfused stomach from normal rats, acute arterial infusion of capsaicin significantly reduced the perfusion pressure of the left gastric artery, with a simultaneous increase in CGRP and somatostatin secretion.	Capsaicin	74-83	calcitonin-related polypeptide alpha	Rattus norvegicus	189-193
8136795-6	1993	These findings provide evidence that capsaicin-sensitive nerves, probably via the release of protective neurotransmitters such as CGRP, play a defensive role in colitis.	Capsaicin	37-46	calcitonin-related polypeptide alpha	Rattus norvegicus	130-134
7904285-9	1993	In isolated perfused stomach from normal rats, acute arterial infusion of capsaicin significantly reduced the perfusion pressure of the left gastric artery, with a simultaneous increase in CGRP and somatostatin secretion.	Capsaicin	74-83	somatostatin	Rattus norvegicus	198-210
7508667-7	1993	By 6-8 weeks both the CGRP- and TH-IR corneal innervation density in the capsaicin-treated animals exceeded that of age-matched control or normal animals; that is, the corneas had become "hyper-reinnervated."	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	22-27
8412505-1	1993	Capsaicin, a homovanillic acid derivative in plants, has distinct pharmacological effects in vivo, e.g. it depletes primary afferent neurons of substance P and other tachykinins.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	144-155
7508667-10	1993	Transection of the ophthalmomaxillary nerve in adult capsaicin-treated animals completely eliminated corneal CGRP-IR staining, and extirpation of the superior cervical ganglion resulted in the loss of 70-80% of corneal TH-IR nerves, thus demonstrating the sensory and predominantly sympathetic origins, respectively, of these fiber populations.	Capsaicin	53-62	calcitonin-related polypeptide alpha	Rattus norvegicus	109-113
7923716-7	1993	In the capsaicin group, the number of DRG-B-type cell with FRAP and AChE activity was obviously reduced as compared with the untreated side of the same body.	Capsaicin	7-16	acid phosphatase 3	Rattus norvegicus	59-63
7923716-7	1993	In the capsaicin group, the number of DRG-B-type cell with FRAP and AChE activity was obviously reduced as compared with the untreated side of the same body.	Capsaicin	7-16	acetylcholinesterase	Rattus norvegicus	68-72
7923716-8	1993	In the capsaicin and electroacupuncture group FRAP and AChE-activities in the DRG-B-type cells were slightly increased.	Capsaicin	7-16	acid phosphatase 3	Rattus norvegicus	46-50
7923716-8	1993	In the capsaicin and electroacupuncture group FRAP and AChE-activities in the DRG-B-type cells were slightly increased.	Capsaicin	7-16	acetylcholinesterase	Rattus norvegicus	55-59
7508667-13	1993	In conclusion, these data show that corneal sensory (CGRP-IR) and sympathetic (TH-IR) nerve fibers undergo extensive sprouting following partial corneal sensory denervation with the neurotoxin capsaicin.	Capsaicin	193-202	calcitonin-related polypeptide alpha	Rattus norvegicus	53-57
1279124-0	1992	Tachykinin systems in the spinal cord and basal ganglia: influence of neonatal capsaicin treatment or dopaminergic intervention on levels of peptides, substance P-encoding mRNAs, and substance P receptor mRNA.	Capsaicin	79-88	tachykinin precursor 1	Homo sapiens	151-162
1279124-7	1992	Capsaicin administration (subcutaneously) during the early postnatal period increased latency in a hot-plate test, decreased SP and NKA levels, increased levels of PPT mRNAs, and did not affect SPR mRNA levels in the spinal cord.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	132-135
1279124-7	1992	Capsaicin administration (subcutaneously) during the early postnatal period increased latency in a hot-plate test, decreased SP and NKA levels, increased levels of PPT mRNAs, and did not affect SPR mRNA levels in the spinal cord.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	164-167
1334505-4	1992	Neonatal capsaicin treatment of the rat results in a 70% decline in CCK receptor binding sites in laminae I and II of the spinal cord, indicating that dorsal root ganglia neurons are a major source of CCK receptors in the spinal cord.	Capsaicin	9-18	cholecystokinin	Rattus norvegicus	68-71
1281498-1	1992	Sensitization to the behavioral effects produced by repeated injections of kainic acid (KA) into the mouse spinal cord area has been previously shown to be abolished by pretreatment with capsaicin, a neurotoxin of substance P (SP)-containing primary afferent C-fibers.	Capsaicin	187-196	tachykinin 1	Mus musculus	214-225
1334505-4	1992	Neonatal capsaicin treatment of the rat results in a 70% decline in CCK receptor binding sites in laminae I and II of the spinal cord, indicating that dorsal root ganglia neurons are a major source of CCK receptors in the spinal cord.	Capsaicin	9-18	cholecystokinin	Rattus norvegicus	201-204
1281498-1	1992	Sensitization to the behavioral effects produced by repeated injections of kainic acid (KA) into the mouse spinal cord area has been previously shown to be abolished by pretreatment with capsaicin, a neurotoxin of substance P (SP)-containing primary afferent C-fibers.	Capsaicin	187-196	tachykinin 1	Mus musculus	227-229
1331550-15	1992	Direct neurochemical evidence was obtained for activation of capsaicin-sensitive primary afferents in the renal pelvis: such a mechanism could be involved in the genesis of ureteral pain whenever bradykinin or FMLP come into contact with sensory nerves in the pyeloureteral wall.	Capsaicin	61-70	kininogen 1	Homo sapiens	196-206
1331550-15	1992	Direct neurochemical evidence was obtained for activation of capsaicin-sensitive primary afferents in the renal pelvis: such a mechanism could be involved in the genesis of ureteral pain whenever bradykinin or FMLP come into contact with sensory nerves in the pyeloureteral wall.	Capsaicin	61-70	formyl peptide receptor 1	Homo sapiens	210-214
1331550-2	1992	Both bradykinin (1 nM-10 microM) and FMLP (10 nM-10 microM) produced a concentration-dependent positive inotropic effect in the isolated renal pelvis which was unaffected by in vitro capsaicin desensitization.	Capsaicin	183-192	formyl peptide receptor 1	Homo sapiens	37-41
1464049-0	1992	Effect of topical application with capsaicin on skin responses to bradykinin and histamine in man.	Capsaicin	35-44	kininogen 1	Homo sapiens	66-76
1281914-0	1992	Release and depletion of substance P by capsaicin in substantia gelatinosa studied with the antibody microprobe technique and immunohistochemistry.	Capsaicin	40-49	tachykinin precursor 1	Homo sapiens	25-36
1281914-1	1992	Using an antibody microprobe technique, we have detected substance P release from the region of the substantia gelatinosa of the cat during the first, but not the second, 30 min of topical application of capsaicin (1-3%) to the tibial nerve.	Capsaicin	204-213	tachykinin precursor 1	Homo sapiens	57-68
1281914-2	1992	Immunohistochemical analysis also showed that substance P-like immunoreactivity was markedly reduced in the superficial layer of the dorsal horn 30 min after application of capsaicin.	Capsaicin	173-182	tachykinin precursor 1	Homo sapiens	46-57
1281914-3	1992	These results indicate that substance P is released and then depleted from primary afferent central terminals following acute application of capsaicin to the peripheral sensory nerve.	Capsaicin	141-150	tachykinin precursor 1	Homo sapiens	28-39
1464049-3	1992	Capsaicin pre-treatment caused significant inhibition of the immediate mean flare responses (95% CI) to both bradykinin (from 51.5 [39.7-63.3] mm2 to 16.2 [8.0-24.5] mm2) (P < 0.01) and histamine (from 108.4 [80.4-136.4] mm2 to 52.3 [37.1-67.1] mm2) (P < 0.01).	Capsaicin	0-9	kininogen 1	Homo sapiens	109-119
1464049-5	1992	In addition, the effect of topical capsaicin was to completely inhibit the bradykinin induced weal response compared to control, the mean weal area (95% CI) being reduced from 13.4 (11.4-15.4) mm2 to 8.2 (5.3-11.0) mm2 (P < 0.01).	Capsaicin	35-44	kininogen 1	Homo sapiens	75-85
1464049-6	1992	Our findings show that repeated topical application with capsaicin led to a significant reduction of the skin responses to intradermal injections with both agonists, and particularly with bradykinin.	Capsaicin	57-66	kininogen 1	Homo sapiens	188-198
1464049-7	1992	The weal responsiveness to bradykinin may entirely follow neuropeptide release from sensory nerves within the skin and the same applies to the flare response, although this is not completely inhibited by topical application with capsaicin.	Capsaicin	229-238	kininogen 1	Homo sapiens	27-37
1397180-3	1992	In tarsal muscles with intact sympathetic innervation, capsaicin injection on Day 2 reduced numbers of perimuscular CGRP-ir sensory nerves by 68% at 3-4 months; however, it did not alter dopamine-beta-hydroxylase-ir nerve density, response to nerve stimulation, or tarsal muscle adrenoceptor-mediated contraction.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	116-120
1397180-5	1992	Sensory denervation by capsaicin improved sympathetic reinnervation, as evidenced by a 174% increase in numbers of DBH-ir nerves and a 62% increase in neurally mediated smooth muscle contraction evoked by electrical stimulation of the contralateral pathway relative to reinnervated muscles of vehicle-injected rats; smooth muscle function was also influenced, as indicated by a decrease toward normal in adrenoceptor sensitivity.	Capsaicin	23-32	dopamine beta-hydroxylase	Rattus norvegicus	115-118
1421086-1	1992	The present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization.	Capsaicin	42-51	JunB proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	143-147
1421086-1	1992	The present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization.	Capsaicin	42-51	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	152-156
1421086-1	1992	The present paper describes the effect of capsaicin-induced stressful stimulus on the expression of immediate early genes (IEGs) c-fos, c-jun, junB and junD in the hypothalamic paraventricular nucleus (PVN) and the central amygdaloid nucleus (ACe) using in situ hybridization.	Capsaicin	42-51	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	129-134
1400023-5	1992	After incubation with phosphoramidon (10(-5) M), we added endothelin-1 cumulatively from 10(-11) to 10(-7) M to the tissues that were treated with capsaicin to deplete the tachykinins.	Capsaicin	147-156	endothelin 1	Homo sapiens	58-70
1280843-3	1992	A first exposure to capsaicin increased the CGRP-LI outflow from the ciliary body (427 +/- 46 fmol/g/30 min), whereas a second challenge with the drug 30 min later, failed to significantly enhance the CGRP-LI outflow (21.8 +/- 15.6 fmol/g/30 min).	Capsaicin	20-29	calcitonin related polypeptide alpha	Homo sapiens	44-48
1280843-4	1992	Likewise, the capsaicin-evoked increase in CGRP-LI outflow from the iris slices (472 +/- 62 fmol/g/30 min) was no longer observed at the second drug administration (38.4 +/- 12.8 fmol/g/30 min).	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	43-47
1280843-6	1992	Reverse phase HPLC analysis of CGRP-LI indicated that authentic CGRP was contained in the tissue and in the superfusate collected during exposure to capsaicin.	Capsaicin	149-158	calcitonin related polypeptide alpha	Homo sapiens	64-68
1280843-7	1992	The present results show that in the human iris and ciliary body, capsaicin releases CGRP possibly contained in terminals of sensory nerves.	Capsaicin	66-75	calcitonin related polypeptide alpha	Homo sapiens	85-89
1400023-6	1992	Phosphoramidon significantly potentiated the endothelin-1-induced contraction in the capsaicin-treated tissues, suggesting that endothelin-1 causes the contraction, at least in part, without releasing tachykinins.	Capsaicin	85-94	endothelin 1	Homo sapiens	45-57
1400023-6	1992	Phosphoramidon significantly potentiated the endothelin-1-induced contraction in the capsaicin-treated tissues, suggesting that endothelin-1 causes the contraction, at least in part, without releasing tachykinins.	Capsaicin	85-94	endothelin 1	Homo sapiens	128-140
1511304-0	1992	Serotonin preferentially hyperpolarizes capsaicin-sensitive C type sensory neurons by activating 5-HT1A receptors.	Capsaicin	40-49	5-hydroxytryptamine receptor 1A	Homo sapiens	97-103
1446140-6	1992	Intraluminal capsaicin (33 microM) had no effect on FLP output and had variable effects on lysozyme output.	Capsaicin	13-22	lysozyme C	Mustela putorius furo	91-99
1383623-6	1992	However, idrapril potentiated capsaicin-induced bronchoconstriction (a model that has been related to the liability of ACE inhibitors to produce cough in patients) less effectively than captopril.	Capsaicin	30-39	angiotensin I converting enzyme	Homo sapiens	119-122
1279751-4	1992	Exposure of the cultures to 10 microM capsaicin and 100 nM RTX for periods of 2 days or longer resulted in almost complete elimination of SP-immunoreactive (IR) neurites and reduction, but not elimination, of CGRP-IR neurites.	Capsaicin	38-47	calcitonin related polypeptide alpha	Homo sapiens	209-213
1379020-0	1992	Time course of capsaicin-evoked release of CGRP from rat spinal cord in vitro.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	43-47
1637084-1	1992	CGRP is released from capsaicin-sensitive sensory neurons in a Ca(2+)-dependent manner in a variety of peripheral organs as well as from central terminals.	Capsaicin	22-31	calcitonin related polypeptide alpha	Homo sapiens	0-4
1637084-2	1992	The mechanisms for CGRP release by low concentrations of capsaicin, electrical antidromic nerve stimulation, and bradykinin have several similar characteristics regarding sensitivity to TTX, CTX, and alpha 2-adrenoceptor activation.	Capsaicin	57-66	calcitonin related polypeptide alpha	Homo sapiens	19-23
1637084-3	1992	High capsaicin concentration and nicotine evoke CGRP release via other mechanisms.	Capsaicin	5-14	calcitonin related polypeptide alpha	Homo sapiens	48-52
1279751-5	1992	In addition, both 10 microM capsaicin and 100 nM RTX significantly reduced the number of SP- and CGRP-IR cell bodies within DRG explants.	Capsaicin	28-37	calcitonin related polypeptide alpha	Homo sapiens	97-101
1279751-6	1992	Capsaicin in 100 microM concentration produced complete elimination of SP-IR fibers and a greater decrease in the number of CGRP-IR fibers, but failed to completely eliminate IR cell bodies.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	124-128
1378463-9	1992	It is concluded that the mouse pancreas contains capsaicin-sensitive sensory CGRP- and substance P-immunoreactive nerve fibers, whereas the galanin-immunoreactive nerve fibers are not sensitive to capsaicin.	Capsaicin	49-58	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	77-81
1386691-6	1992	In study 2 the geometric mean value of the cough threshold of response to capsaicin before inhalation of procaterol (4.61 (GSE 1.84) micrograms/ml) was not different from that after inhalation of procaterol (4.61 (GSE 1.84) micrograms/ml), which had significant bronchodilator effects.	Capsaicin	74-83	Gse1 coiled-coil protein	Homo sapiens	123-128
1590437-8	1992	We conclude that 1) topical application of capsaicin stimulates capsaicin-sensitive sensory neurons and induces dose-dependent arteriolar dilation; 2) this vasodilation is mediated in part by CGRP; and 3) CGRP may be involved in modulating the basal tone of gastric resistance vessels.	Capsaicin	43-52	calcitonin related polypeptide alpha	Homo sapiens	192-196
1590437-8	1992	We conclude that 1) topical application of capsaicin stimulates capsaicin-sensitive sensory neurons and induces dose-dependent arteriolar dilation; 2) this vasodilation is mediated in part by CGRP; and 3) CGRP may be involved in modulating the basal tone of gastric resistance vessels.	Capsaicin	43-52	calcitonin related polypeptide alpha	Homo sapiens	205-209
1590437-8	1992	We conclude that 1) topical application of capsaicin stimulates capsaicin-sensitive sensory neurons and induces dose-dependent arteriolar dilation; 2) this vasodilation is mediated in part by CGRP; and 3) CGRP may be involved in modulating the basal tone of gastric resistance vessels.	Capsaicin	64-73	calcitonin related polypeptide alpha	Homo sapiens	205-209
1355435-15	1992	capsaicin-induced bronchospasm through activation of postjunctional NK2 (but not NK1) receptors along with activation of cholinergic pathways.	Capsaicin	0-9	tachykinin receptor 2	Homo sapiens	68-71
1315978-5	1992	The relaxing capacity of ET-1 was absent when the tissue was precontracted by potassium yet was resistant to pretreatments with tetrodotoxin, capsaicin, propranolol, indomethacin, NG-methyl-L-arginine or glibenclamide.	Capsaicin	142-151	endothelin 1	Rattus norvegicus	25-29
1315979-5	1992	Pretreatment with the selective sensory neurotoxin capsaicin decreased gastroduodenal CGRP-li but not NKA-, galanin-, VIP- or NPY-li, showing that CGRP might be considered a marker of the afferent innervation of the gastroduodenal tract.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
1315979-5	1992	Pretreatment with the selective sensory neurotoxin capsaicin decreased gastroduodenal CGRP-li but not NKA-, galanin-, VIP- or NPY-li, showing that CGRP might be considered a marker of the afferent innervation of the gastroduodenal tract.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	147-151
1315979-6	1992	The residual gastroduodenal CGRP-li levels in capsaicin-pretreated animals were not decreased by cysteamine administration, indicating that the effect of cysteamine is restricted to a peptide pool of primary afferent origin.	Capsaicin	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	28-32
1354538-3	1992	), in the presence of atropine 1 microM and of the beta-adrenoceptor blocker CGP 20712A 1 microM, induced a positive inotropic effect which was reduced by the calcitonin gene-related peptide (CGRP) antagonist hCGRP-(8-37) and abolished by pretreatment with capsaicin 1 microM.	Capsaicin	257-266	calcitonin related polypeptide alpha	Homo sapiens	192-196
1380376-9	1992	In 4 out of 6 preparations a cross-desensitization between substance P and capsaicin was observed.	Capsaicin	75-84	tachykinin 1	Mus musculus	59-70
1374461-0	1992	Neonatal capsaicin treatment attenuates spinal Fos activation and dynorphin gene expression following peripheral tissue inflammation and hyperalgesia.	Capsaicin	9-18	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-50
1374461-4	1992	However, the inflammation-induced increases in Fos-like immunoreactivity (Fos-LI) and in PPD mRNA were greatly attenuated by neonatal capsaicin treatment.	Capsaicin	134-143	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	47-50
1374461-4	1992	However, the inflammation-induced increases in Fos-like immunoreactivity (Fos-LI) and in PPD mRNA were greatly attenuated by neonatal capsaicin treatment.	Capsaicin	134-143	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	74-77
1374461-4	1992	However, the inflammation-induced increases in Fos-like immunoreactivity (Fos-LI) and in PPD mRNA were greatly attenuated by neonatal capsaicin treatment.	Capsaicin	134-143	prodynorphin	Homo sapiens	89-92
1374461-6	1992	Our finding that neonatal capsaicin reduces the levels of Fos-LI and PPD mRNA in a related fashion in the spinal dorsal horn provides further evidence for a relationship between the protein product of the c-fos protooncogene and regulation of dynorphin gene transcription.	Capsaicin	26-35	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-61
1374461-6	1992	Our finding that neonatal capsaicin reduces the levels of Fos-LI and PPD mRNA in a related fashion in the spinal dorsal horn provides further evidence for a relationship between the protein product of the c-fos protooncogene and regulation of dynorphin gene transcription.	Capsaicin	26-35	prodynorphin	Homo sapiens	69-72
1374461-6	1992	Our finding that neonatal capsaicin reduces the levels of Fos-LI and PPD mRNA in a related fashion in the spinal dorsal horn provides further evidence for a relationship between the protein product of the c-fos protooncogene and regulation of dynorphin gene transcription.	Capsaicin	26-35	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	205-210
1373708-2	1992	Local pretreatment with capsaicin produces decreased substance P-dependent erythema, with edema similar to that observed before pretreatment with capsaicin.	Capsaicin	24-33	tachykinin precursor 1	Homo sapiens	53-64
1317373-3	1992	To investigate the relative contribution of capsaicin-sensitive sensory neural stimulation to the action(s) of bradykinin, two randomized double-blind placebo-controlled studies have been undertaken comparing the nasal effects of single-dose administrations of bradykinin (1.88 x 10(-3) M) and capsaicin (3.28 x 10(-5) M).	Capsaicin	44-53	kininogen 1	Homo sapiens	111-121
1322224-1	1992	Using in vitro quantitative receptor autoradiography the present study reports on the distribution and possible changes of [125I]neuropeptide Y (NPY) binding sites in the rat spinal cord following neonatal capsaicin treatment, dorsal rhizotomy and sciatic nerve section.	Capsaicin	206-215	neuropeptide Y	Rattus norvegicus	123-143
1322224-1	1992	Using in vitro quantitative receptor autoradiography the present study reports on the distribution and possible changes of [125I]neuropeptide Y (NPY) binding sites in the rat spinal cord following neonatal capsaicin treatment, dorsal rhizotomy and sciatic nerve section.	Capsaicin	206-215	neuropeptide Y	Rattus norvegicus	145-148
1322224-3	1992	In comparison with control rats, neonatally treated capsaicin rats showed a significant (P less than 0.001) bilateral decrease in [125I]NPY binding sites in the superficial layers of the dorsal horn.	Capsaicin	52-61	neuropeptide Y	Rattus norvegicus	136-139
1617430-0	1992	Effects of nerve growth factor on TTX- and capsaicin-sensitivity in adult rat sensory neurons.	Capsaicin	43-52	nerve growth factor	Rattus norvegicus	11-30
1409001-5	1992	The inhibitory effect of hIL-1 beta was blocked by indomethacin and was not modified by IV injections of the CRF receptor antagonist, alpha-helical CRF(9-41), or the monoclonal somatostatin antibody CURE.S6, or by systemic capsaicin pretreatment.	Capsaicin	223-232	interleukin 1 beta	Homo sapiens	25-35
1371395-2	1992	In addition, the effects of capsaicin were examined as it is known to release (and to deplete) SP and calcitonin gene-related peptide from C-fibres.	Capsaicin	28-37	tachykinin precursor 1	Homo sapiens	95-97
1371395-8	1992	Repeated injections of capsaicin and bradykinin produced tachyphylaxis (and cross-tachyphylaxis) and greatly reduced the SP-evoked flare.	Capsaicin	23-32	tachykinin precursor 1	Homo sapiens	121-123
1371395-11	1992	The flare response to SP following capsaicin- or bradykinin-induced desensitization gradually returned to normal after 5-8 weeks.	Capsaicin	35-44	tachykinin precursor 1	Homo sapiens	22-24
1374131-6	1992	On the other hand, while lesions of substance P-ergic fibers appeared quite stable, partial recovery of CGRP innervation was found after 3 to 6 months, especially with the low dose of capsaicin.	Capsaicin	184-193	calcitonin-related polypeptide alpha	Rattus norvegicus	104-108
1617430-7	1992	For example, the percent of neurons in which a current activated by 8-methyl-N-vanillyl-6-nonenamide (capsaicin, 500 nM) was detected, increased from 18% in untreated cells to 55% in NGF-treated cells.	Capsaicin	68-100	nerve growth factor	Rattus norvegicus	183-186
1617430-7	1992	For example, the percent of neurons in which a current activated by 8-methyl-N-vanillyl-6-nonenamide (capsaicin, 500 nM) was detected, increased from 18% in untreated cells to 55% in NGF-treated cells.	Capsaicin	102-111	nerve growth factor	Rattus norvegicus	183-186
1617430-9	1992	The results indicate that NGF can regulate TTX and capsaicin sensitivity in these adult rat sensory neurons.	Capsaicin	51-60	nerve growth factor	Rattus norvegicus	26-29
1371709-0	1992	Effect of neonatal capsaicin treatment on cholecystokinin-(CCK8) satiety and axonal transport of CCK binding sites in the rat vagus nerve.	Capsaicin	19-28	cholecystokinin	Rattus norvegicus	42-57
1371709-0	1992	Effect of neonatal capsaicin treatment on cholecystokinin-(CCK8) satiety and axonal transport of CCK binding sites in the rat vagus nerve.	Capsaicin	19-28	cholecystokinin	Rattus norvegicus	59-62
1371709-2	1992	Treatment of neonatal rats with capsaicin attenuated the satiety effect of injected CCK in adult life.	Capsaicin	32-41	cholecystokinin	Rattus norvegicus	84-87
1371709-3	1992	Capsaicin pretreatment also reduced, but did not eliminate, the accumulation of CCK binding sites proximal and distal to ligatures on either cervical trunk.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	80-83
1371709-5	1992	The CCK receptor antagonists, MK-329 and L-365,260, inhibited binding to capsaicin- and vehicle-treated nerves to a similar degree.	Capsaicin	73-82	cholecystokinin	Rattus norvegicus	4-7
1371709-6	1992	Densities of CCK binding sites in the nucleus tractus solitarius and area postrema were also markedly affected by neonatal capsaicin treatment.	Capsaicin	123-132	cholecystokinin	Rattus norvegicus	13-16
1543589-2	1992	The present experiments show that vagal sensory fibres mediate CCK-induced c-fos in brain stem neurons, based on the findings that perivagal capsaicin pre-treatment in seven out of eight cases reduced or ablated c-fos expression in these regions.	Capsaicin	141-150	cholecystokinin	Rattus norvegicus	63-66
1374925-0	1992	Time-course of capsaicin-evoked release of calcitonin gene-related peptide from rat spinal cord in vitro.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	43-74
1374925-2	1992	The capsaicin-evoked release of calcitonin gene-related peptide (CGRP) from rat superfused dorsal spinal cord slices was investigated during sustained capsaicin exposure thought to represent equilibrium conditions.	Capsaicin	4-13	calcitonin-related polypeptide alpha	Rattus norvegicus	32-63
1374925-2	1992	The capsaicin-evoked release of calcitonin gene-related peptide (CGRP) from rat superfused dorsal spinal cord slices was investigated during sustained capsaicin exposure thought to represent equilibrium conditions.	Capsaicin	4-13	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
1374925-6	1992	When cumulative dose regimens for capsaicin were employed, release of CGRP could be stimulated only up to a dose of 1-1.5 microM capsaicin; further increase in capsaicin concentration was ineffective.	Capsaicin	34-43	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74
1374925-6	1992	When cumulative dose regimens for capsaicin were employed, release of CGRP could be stimulated only up to a dose of 1-1.5 microM capsaicin; further increase in capsaicin concentration was ineffective.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74
1374925-6	1992	When cumulative dose regimens for capsaicin were employed, release of CGRP could be stimulated only up to a dose of 1-1.5 microM capsaicin; further increase in capsaicin concentration was ineffective.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	70-74
1374925-8	1992	Release of CGRP evoked by capsaicin concentrations in the range of 0.1-0.3 microM in either dosage protocol was reduced in the presence of Ruthenium Red (RR, 2.5 microM).	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
1378693-7	1992	Similarly, stimulation of afferent sensory neurons by intragastric capsaicin (0.5 mg/kg) protected against damage caused by endothelin-1 and 20% ethanol.	Capsaicin	67-76	endothelin 1	Rattus norvegicus	124-136
1596682-14	1992	In rats neonatally treated with capsaicin (50 mg kg-1, s.c.), the pressor effects elicited by neurotensin (300 and 1000 ng) were reduced as were the constrictor responses in the renal (at the dose of 300 ng), superior mesenteric (at the dose of 300 ng) and hindquarters (at both doses) vascular beds.	Capsaicin	32-41	neurotensin	Rattus norvegicus	94-105
1543589-2	1992	The present experiments show that vagal sensory fibres mediate CCK-induced c-fos in brain stem neurons, based on the findings that perivagal capsaicin pre-treatment in seven out of eight cases reduced or ablated c-fos expression in these regions.	Capsaicin	141-150	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	75-80
1592225-2	1992	N-Ethylmaleimide</compound-id> (NEM) and capsaicin induced a release of calcitonin gene-related peptide-like immunoreactivity (CGRP-li) in superfusates from rat gastric corpus.	Capsaicin	41-50	calcitonin-related polypeptide alpha	Rattus norvegicus	127-131
1543589-2	1992	The present experiments show that vagal sensory fibres mediate CCK-induced c-fos in brain stem neurons, based on the findings that perivagal capsaicin pre-treatment in seven out of eight cases reduced or ablated c-fos expression in these regions.	Capsaicin	141-150	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	212-217
1592225-4	1992	The prior application of capsaicin completely blocked CGRP-li release by NEM while the exposure to NEM reduced the capsaicin-evoked CGRP-li outflow by about 51%.	Capsaicin	25-34	calcitonin-related polypeptide alpha	Rattus norvegicus	54-58
1732343-2	1992	Topical capsaicin depletes and prevents the reaccumulation of substance P in peripheral sensory neurons.	Capsaicin	8-17	tachykinin precursor 1	Homo sapiens	62-73
1592225-4	1992	The prior application of capsaicin completely blocked CGRP-li release by NEM while the exposure to NEM reduced the capsaicin-evoked CGRP-li outflow by about 51%.	Capsaicin	115-124	calcitonin-related polypeptide alpha	Rattus norvegicus	132-136
1592225-6	1992	These findings provide evidence that NEM might exert capsaicin-like activity in rat stomach and the release of CGRP-li from capsaicin-sensitive afferent fibres might influence the properties exerted by NEM in this tissue.	Capsaicin	124-133	calcitonin-related polypeptide alpha	Rattus norvegicus	111-115
1379316-1	1992	Hypertonic NaCl (160 mM added to the physiological salt solution) releases CGRP in a Ca(2+)-dependent manner from capsaicin-sensitive sensory nerves of the rat urinary bladder.	Capsaicin	114-123	calcitonin-related polypeptide alpha	Rattus norvegicus	75-79
1377821-5	1992	In contrast, prior stimulation with K+ 120 mM significantly enhanced the CGRP release induced by a second stimulation with K+ 120 mM or capsaicin 10(-5) M. Capsaicin- and K(+)-induced peptide release was diminished or abolished in the absence of Ca2+.	Capsaicin	136-145	calcitonin-related polypeptide alpha	Rattus norvegicus	73-77
1284617-3	1992	The discovery of mediator function of "substance P" (SP), other related peptides, which coexists and realizes from the primary afferents and other terminals of SP-containing, capsaicin-sensitive neurons--opened a new chapter in the neurobiology and medicine.	Capsaicin	175-184	tachykinin precursor 1	Homo sapiens	38-51
1347651-7	1992	Application of capsaicin (10 microM) produced a marked increase in the outflow of substance P-, neurokinin A- and CGRP-like immunoreactivities from the superfused guinea-pig renal pelvis.	Capsaicin	15-24	tachykinin precursor 1	Homo sapiens	96-108
1347651-7	1992	Application of capsaicin (10 microM) produced a marked increase in the outflow of substance P-, neurokinin A- and CGRP-like immunoreactivities from the superfused guinea-pig renal pelvis.	Capsaicin	15-24	calcitonin related polypeptide alpha	Homo sapiens	114-118
1584413-5	1992	Only 67% of cells excited by capsaicin were sensitive to exogenous substance P.	Capsaicin	29-38	tachykinin 1	Mus musculus	67-78
1377821-2	1992	In accord with the relative tissue levels of the respective peptides, capsaicin (10(-8) to 10(-5) M) and K+ (120 mM) added to the perfusate resulted in a concentration-dependent increase in the levels of CGRP and NKA, and to a minor extent SP, in the perfusates.	Capsaicin	70-79	calcitonin-related polypeptide alpha	Rattus norvegicus	204-208
1377821-3	1992	Sequential exposure of the trachea to capsaicin revealed a concentration-dependent tachyphylaxis of CGRP release.	Capsaicin	38-47	calcitonin-related polypeptide alpha	Rattus norvegicus	100-104
1377821-5	1992	In contrast, prior stimulation with K+ 120 mM significantly enhanced the CGRP release induced by a second stimulation with K+ 120 mM or capsaicin 10(-5) M. Capsaicin- and K(+)-induced peptide release was diminished or abolished in the absence of Ca2+.	Capsaicin	156-165	calcitonin-related polypeptide alpha	Rattus norvegicus	73-77
1377821-7	1992	These data demonstrate that CGRP, NKA and SP exist in releasable, capsaicin-sensitive pools in terminals which lie within the proximal lumen of the trachea.	Capsaicin	66-75	calcitonin-related polypeptide alpha	Rattus norvegicus	28-32
1595321-1	1992	In the enteric nervous system, calcitonin gene-related peptide (CGRP) immunoreactivity is localized to a substantial number of capsaicin-sensitive afferent fibers and to intrinsic neurons and processes.	Capsaicin	127-136	calcitonin-related polypeptide alpha	Rattus norvegicus	31-62
1595321-1	1992	In the enteric nervous system, calcitonin gene-related peptide (CGRP) immunoreactivity is localized to a substantial number of capsaicin-sensitive afferent fibers and to intrinsic neurons and processes.	Capsaicin	127-136	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
1719983-2	1991	The effect of CGRP was present in the low nanomolar dose range, and it was mimicked by activation of sensory nerves with capsaicin which caused release of endogenous CGRP-like immunoreactivity (IR).	Capsaicin	121-130	calcitonin related polypeptide alpha	Homo sapiens	14-18
1719983-2	1991	The effect of CGRP was present in the low nanomolar dose range, and it was mimicked by activation of sensory nerves with capsaicin which caused release of endogenous CGRP-like immunoreactivity (IR).	Capsaicin	121-130	calcitonin related polypeptide alpha	Homo sapiens	166-170
1797334-0	1991	A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin.	Capsaicin	116-125	calcitonin related polypeptide alpha	Homo sapiens	35-39
1726597-7	1991	Epineurial capsaicin induced a prompt, intense and prolonged increase in EBF and lowering of EMR as compared to epineurial application of the carrier alone in a separate animal group.	Capsaicin	11-20	EBF transcription factor 1	Rattus norvegicus	73-76
1726597-12	1991	When co-administered with capsaicin, hCGRP (8-37) completely blocked the hyperaemic response and increased EMR above the pooled control range.	Capsaicin	26-35	calcitonin related polypeptide alpha	Homo sapiens	37-42
1722940-0	1991	Resiniferatoxin-, capsaicin- and CGRP-evoked porcine coronary vasodilatation is independent of EDRF mechanisms but antagonized by CGRP(8-37).	Capsaicin	18-27	calcitonin related polypeptide alpha	Homo sapiens	130-134
1683166-0	1991	Linkage between capsaicin-stimulated calcitonin gene-related peptide and somatostatin release in rat stomach.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	37-68
1683166-5	1991	On the other hand, arterial infusion of capsaicin significantly increased the release of not only CGRP but also somatostatin from the stomach of normal rats.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	98-102
1683166-7	1991	Finally, human CGRP-(8-37), a CGRP-receptor antagonist, completely inhibited the increase of gastric somatostatin induced by both rat alpha-CGRP and capsaicin infusion in normal rats.	Capsaicin	149-158	calcitonin related polypeptide alpha	Homo sapiens	15-19
1683166-8	1991	Thus the capsaicin-induced increase of somatostatin release appears to be mediated by CGRP in the stomach.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
1797334-16	1991	The results suggest that capsaicin acts to release a rabbit form of CGRP in skin and that CGRP8 37 is a useful antagonist for investigating the potential of CGRP as a neurogenic mediator of inflammation.	Capsaicin	25-34	calcitonin related polypeptide alpha	Homo sapiens	68-72
1797334-0	1991	A calcitonin gene-related peptide (CGRP) antagonist (CGRP8-37) inhibits microvascular responses induced by CGRP and capsaicin in skin.	Capsaicin	116-125	calcitonin related polypeptide alpha	Homo sapiens	53-57
1721077-0	1991	Developmental alterations in nociceptive threshold, immunoreactive calcitonin gene-related peptide and substance P, and fluoride-resistant acid phosphatase in neonatally capsaicin-treated rats.	Capsaicin	170-179	calcitonin-related polypeptide alpha	Rattus norvegicus	67-98
1721077-0	1991	Developmental alterations in nociceptive threshold, immunoreactive calcitonin gene-related peptide and substance P, and fluoride-resistant acid phosphatase in neonatally capsaicin-treated rats.	Capsaicin	170-179	acid phosphatase 3	Rattus norvegicus	120-155
1839282-1	1991	The effects of the agonist of 5-HT1A receptors, 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT), on the capsaicin-induced cough reflex in rats were studied.	Capsaicin	107-116	5-hydroxytryptamine receptor 1A	Rattus norvegicus	30-36
1656776-0	1991	Role of calcitonin gene-related peptide in gastric hyperemic response to intragastric capsaicin.	Capsaicin	86-95	calcitonin-related polypeptide alpha	Rattus norvegicus	8-39
1724624-0	1991	Ruthenium-red inhibits CGRP release by capsaicin and resiniferatoxin but not by ouabain, bradykinin or nicotine in guinea-pig heart: correlation with effects on cardiac contractility.	Capsaicin	39-48	calcitonin related polypeptide alpha	Homo sapiens	23-27
1719791-6	1991	Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.	Capsaicin	9-18	calcitonin related polypeptide alpha	Homo sapiens	88-93
1724624-4	1991	In the isolated right atrium, exposure to capsaicin evoked an increase in contractile rate and tension simultaneously with an enhanced outflow of CGRP-LI, indicating release from the atria.	Capsaicin	42-51	calcitonin related polypeptide alpha	Homo sapiens	146-150
1724624-6	1991	Incubation with RR markedly attenuated the capsaicin-evoked release of CGRP-LI while no clear-cut effects were seen on contractile tension or rate.	Capsaicin	43-52	calcitonin related polypeptide alpha	Homo sapiens	71-75
1724624-8	1991	In the isolated whole heart, perfusion with capsaicin induced an increased outflow of CGRP-LI and stimulated heart rate, while a negative inotropic effect was observed.	Capsaicin	44-53	calcitonin related polypeptide alpha	Homo sapiens	86-90
1724624-11	1991	However, after 1 h of rinsing with Tyrode solution repeated capsaicin perfusion in the absence of RR caused a clear-cut (60% of control) release of CGRP-LI and contractile responses were restored.	Capsaicin	60-69	calcitonin related polypeptide alpha	Homo sapiens	148-152
1718773-8	1991	The capsaicin-induced relaxation was reproducible and it was concentration dependently inhibited by ruthenium red which suggests that capsaicin releases CGRP in the arterial wall.	Capsaicin	4-13	calcitonin related polypeptide alpha	Homo sapiens	153-157
1718773-8	1991	The capsaicin-induced relaxation was reproducible and it was concentration dependently inhibited by ruthenium red which suggests that capsaicin releases CGRP in the arterial wall.	Capsaicin	134-143	calcitonin related polypeptide alpha	Homo sapiens	153-157
1922967-1	1991	The possible mediating role of calcitonin gene-related peptide (CGRP) in the effects of capsaicin in the guinea-pig ileum has been investigated by means of the CGRP antagonist hCGRP(8-37).	Capsaicin	88-97	calcitonin-related polypeptide alpha	Rattus norvegicus	64-68
1922967-2	1991	Submaximal longitudinal muscle relaxation of the histamine-precontracted ileum evoked by rat CGRP (3 nM) or capsaicin (1 microM) was reversed by hCGRP(8-37) (1.5 microM), while that due to adrenaline or neurotensin was not affected.	Capsaicin	108-117	neurotensin	Rattus norvegicus	203-214
1922967-5	1991	It is concluded that (a) hCGRP(8-37) is a specific CGRP antagonist in the ileum, apparently devoid of intrinsic activity or any effect not related to CGRP; (b) the inhibitory actions of capsaicin on the longitudinal and circular muscles of the ileum are mediated, at least in part, by CGRP.	Capsaicin	186-195	calcitonin-related polypeptide alpha	Rattus norvegicus	26-30
1719791-6	1991	Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.	Capsaicin	9-18	neuropeptide Y	Homo sapiens	227-230
1719791-6	1991	Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.	Capsaicin	9-18	tyrosine hydroxylase	Homo sapiens	235-255
1722032-7	1991	The capsaicin (0.5 microM)-evoked release of immunoreactive SP from dorsal-half slices of the spinal cord was increased by galanin (1 microM, but not 0.1 microM) without effects on basal release.	Capsaicin	4-13	galanin and GMAP prepropeptide	Rattus norvegicus	123-130
1719791-6	1991	Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.	Capsaicin	9-18	tyrosine hydroxylase	Homo sapiens	257-259
1719791-6	1991	Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.	Capsaicin	9-18	vasoactive intestinal peptide	Homo sapiens	296-299
1719791-6	1991	Neonatal capsaicin, at the doses employed in this study, destroyed approximately 70% of CGRP- and tachykinin-immunoreactive sensory axons; whereas 6-hydroxydopamine (6-OHDA) at the doses employed resulted in a complete loss of NPY and tyrosine hydroxylase (TH) immunoreactivity without affecting VIP, CGRP, and tachykinins.	Capsaicin	9-18	calcitonin related polypeptide alpha	Homo sapiens	88-92
1719791-9	1991	Not all sensory axons immunoreactive for CGRP and substance P/NKA are capsaicin-sensitive.	Capsaicin	70-79	tachykinin precursor 1	Homo sapiens	50-61
1719791-9	1991	Not all sensory axons immunoreactive for CGRP and substance P/NKA are capsaicin-sensitive.	Capsaicin	70-79	tachykinin precursor 1	Homo sapiens	62-65
1718522-10	1991	The relaxation was partly inhibited by ruthenium red, thus suggesting that capsaicin causes specific release of CGRP from sensory nerve endings in rat coronary arteries.	Capsaicin	75-84	calcitonin-related polypeptide alpha	Rattus norvegicus	112-116
1924895-4	1991	Capsaicin (a sensory stimulant known to release CGRP from primary afferents) also inhibited CM activity.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	48-52
1716741-0	1991	Capsaicin-induced release of neurokinin A from muscle and mucosa of gastric corpus: correlation with capsaicin-evoked release of calcitonin gene-related peptide.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	129-160
1710573-6	1991	Another group of animals was given the neurotoxin capsaicin which causes a depletion of SP and CGRP from sensory axons.	Capsaicin	50-59	calcitonin-related polypeptide alpha	Rattus norvegicus	95-99
1710573-8	1991	Very few SP- and CGRP-IR fibers were present in capsaicin-treated animals.	Capsaicin	48-57	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
1716741-4	1991	A large depletion (about 80%) of CGRP-LI following capsaicin treatment was observed in all regions examined, while no difference was observed for NKA-LI and SP-LI.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
1716741-5	1991	NKA-LI, SP-LI and CGRP-LI release induced by capsaicin was measured in different regions of the rat stomach.	Capsaicin	45-54	calcitonin-related polypeptide alpha	Rattus norvegicus	18-22
1716741-0	1991	Capsaicin-induced release of neurokinin A from muscle and mucosa of gastric corpus: correlation with capsaicin-evoked release of calcitonin gene-related peptide.	Capsaicin	101-110	calcitonin-related polypeptide alpha	Rattus norvegicus	129-160
1716741-6	1991	Both in the gastric fundus and in the corpus, capsaicin (10 microM) produced a remarkable release of of CGRP-LI and NKA-LI, but not of SP-LI.	Capsaicin	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	104-108
1716741-2	1991	In this study, it was examined whether capsaicin might induce the release of neurokinin A (NKA), substance P (SP) and calcitonin gene-related peptide (CGRP) from different regions of rat stomach.	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	118-149
1716741-8	1991	In the gastric corpus, the capsaicin-induced NKA-LI and CGRP-LI release was larger from the muscle layer than from the mucosa.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	56-60
1716741-2	1991	In this study, it was examined whether capsaicin might induce the release of neurokinin A (NKA), substance P (SP) and calcitonin gene-related peptide (CGRP) from different regions of rat stomach.	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	151-155
1716741-9	1991	The present findings provide neurochemical evidence that both NKA-LI and CGRP-LI are released from different regions of the rat stomach and both peptides should therefore be taken into account when considering the efferent function of capsaicin-sensitive primary afferents at gastric level.	Capsaicin	235-244	calcitonin-related polypeptide alpha	Rattus norvegicus	73-77
1884100-0	1991	Prejunctional modulatory action of neuropeptide Y on responses due to antidromic activation of peripheral terminals of capsaicin-sensitive sensory nerves in the isolated guinea-pig ileum.	Capsaicin	119-128	pro-neuropeptide Y	Cavia porcellus	35-49
1884100-2	1991	The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli.	Capsaicin	80-89	pro-neuropeptide Y	Cavia porcellus	14-28
1884100-2	1991	The effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated ileum was determined by use of capsaicin itself and electrical mesenteric nerve stimulation as stimuli.	Capsaicin	80-89	pro-neuropeptide Y	Cavia porcellus	30-33
1884100-4	1991	NPY inhibited or suppressed the cholinergic contractile response produced by electrical mesenteric nerve stimulation while leaving the contractile response to a threshold concentration of capsaicin.	Capsaicin	188-197	pro-neuropeptide Y	Cavia porcellus	0-3
1884100-8	1991	It is concluded that NPY exerted a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin-sensitive nerves at interneuronal synapses.	Capsaicin	117-126	pro-neuropeptide Y	Cavia porcellus	21-24
1882089-0	1991	Release of calcitonin gene-related peptide in the pig nasal mucosa by antidromic nerve stimulation and capsaicin.	Capsaicin	103-112	Calcitonin gene-related peptide	Sus scrofa	11-42
1714353-9	1991	CGRP- and SP-immunoreactive nerve fibers were dramatically reduced in periosteum of capsaicin-treated animals as compared to controls, indicating the sensory origin of these nerves.	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	0-5
1922926-0	1991	The immediate-early genes c-fos and c-jun are differentially expressed in the rat adrenal gland after capsaicin treatment.	Capsaicin	102-111	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	26-31
1922926-1	1991	In situ hybridization histochemistry was used to study the expression of c-fos and c-jun mRNA in the rat adrenal gland of untreated and capsaicin treated rats.	Capsaicin	136-145	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	73-78
1922926-4	1991	After capsaicin (25 mg/kg, s.c.), a rapid increase in both c-fos and c-jun mRNA levels was observed in adrenal medulla.	Capsaicin	6-15	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	59-64
1922926-5	1991	Capsaicin also induced an increase in c-fos mRNA levels in all 3 cortical layers, especially in the zona glomerulosa, whereas only small changes in c-jun mRNA levels were seen in zona fasciculata and reticulata.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-43
1922926-6	1991	The present results indicate that c-fos and c-jun mRNA levels are both increased in the adrenal gland after capsaicin treatment, although the time course, magnitude and regional distribution of these increases differed for the two mRNAs.	Capsaicin	108-117	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	34-39
1715797-7	1991	Co-administration of SP and NKA mimicked the response to capsaicin more than each TK alone.	Capsaicin	57-66	tachykinin precursor 1	Homo sapiens	28-31
1947724-7	1991	Exogenous CGRP caused a near-complete relaxation of the methoxamine-contracted hepatic artery both before and after capsaicin treatment.	Capsaicin	116-125	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
1947724-9	1991	These findings show that responses to transmural stimulation of the hepatic artery are modulated after pretreatment with capsaicin, indicating release of relaxing substances such as CGRP, presumably from capsaicin-sensitive neuronal stores.	Capsaicin	121-130	calcitonin-related polypeptide alpha	Rattus norvegicus	182-186
1947724-9	1991	These findings show that responses to transmural stimulation of the hepatic artery are modulated after pretreatment with capsaicin, indicating release of relaxing substances such as CGRP, presumably from capsaicin-sensitive neuronal stores.	Capsaicin	204-213	calcitonin-related polypeptide alpha	Rattus norvegicus	182-186
1717894-0	1991	Ruthenium red selectively antagonizes capsaicin-induced release of vasoactive intestinal polypeptide (VIP) from the human colon.	Capsaicin	38-47	vasoactive intestinal peptide	Homo sapiens	67-100
1717894-0	1991	Ruthenium red selectively antagonizes capsaicin-induced release of vasoactive intestinal polypeptide (VIP) from the human colon.	Capsaicin	38-47	vasoactive intestinal peptide	Homo sapiens	102-105
1717894-2	1991	The aim of this study was to assess whether RR is able to antagonize the release of vasoactive intestinal polypeptide (VIP) evoked by capsaicin in the human colon.	Capsaicin	134-143	vasoactive intestinal peptide	Homo sapiens	84-117
1717894-2	1991	The aim of this study was to assess whether RR is able to antagonize the release of vasoactive intestinal polypeptide (VIP) evoked by capsaicin in the human colon.	Capsaicin	134-143	vasoactive intestinal peptide	Homo sapiens	119-122
1717894-5	1991	Either capsaicin or high K+ produced a prompt release of VIP.	Capsaicin	7-16	vasoactive intestinal peptide	Homo sapiens	57-60
1717894-6	1991	RR (10 microM) completely antagonized the capsaicin-induced release of VIP from muscle of human colon.	Capsaicin	42-51	vasoactive intestinal peptide	Homo sapiens	71-74
1882089-1	1991	The overflow of calcitonin gene-related peptide like-immunoreactivity (CGRP-LI) in the nasal venous effluent upon antidromic stimulation of the maxillary division of the trigeminal nerve with 6.9 Hz for 3 min or upon capsaicin (0.3 mumol bolus injection) were analysed in the nasal mucosa of sympathectomized pentobarbital anaesthetized pigs.	Capsaicin	217-226	Calcitonin gene-related peptide	Sus scrofa	71-75
1882089-2	1991	The overflow of CGRP-LI upon antidromic stimulation displayed a slower appearance in the venous effluent than the overflow upon bolus injection of capsaicin.	Capsaicin	147-156	Calcitonin gene-related peptide	Sus scrofa	16-20
1882089-4	1991	Antidromic stimulation of the trigeminal nerve as well as capsaicin bolus injection induced a marked vasodilation which was parallel to the overflow of CGRP.	Capsaicin	58-67	Calcitonin gene-related peptide	Sus scrofa	152-156
1882089-6	1991	In conclusion, we have demonstrated that chemical stimulation with capsaicin as well as antidromic stimulation of nasal sensory nerves in sympathectomized animals induces both vasodilation and overflow of CGRP-LI in vivo.	Capsaicin	67-76	Calcitonin gene-related peptide	Sus scrofa	205-209
1716572-5	1991	It is concluded that capsaicin excitation of primary afferents in the human ileum, leading to VIP release and muscle relaxation, occurs with mechanisms similar to those operating in animal tissues and that ruthenium red acts as a selective capsaicin antagonist in the human ileum.	Capsaicin	21-30	vasoactive intestinal peptide	Homo sapiens	94-97
1713906-7	1991	Because NEP is important in modulating the airway effects of endogenously released tachykinins after tracheal infusion of capsaicin, but ACE is not, it seems likely that tracheal administration of capsaicin releases tachykinins from epithelial rather than endothelial loci.	Capsaicin	197-206	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	137-140
1654749-3	1991	The levels of the neuropeptides neurokinin A and calcitonin gene-related peptide were decreased in the lung after capsaicin treatment, as determined with radioimmunoassay, whereas the levels of neuropeptide Y were unaffected.	Capsaicin	114-123	pyroglutamylated RFamide peptide	Rattus norvegicus	18-30
1654749-6	1991	The results demonstrated that reduction of neuropeptide levels with capsaicin affected both bronchial reactivity and the levels of antibodies in bronchial lavage fluid.	Capsaicin	68-77	pyroglutamylated RFamide peptide	Rattus norvegicus	43-55
1881975-1	1991	Adult male mice of albino Swiss-derived CD-1 strain were used to assess the effects of capsaicin (a powerful agent that produces a marked depletion of the undecapeptide substance P) on both intraspecific aggressive behavior (induced by 8 weeks of individual housing) and pain sensitivity.	Capsaicin	87-96	tachykinin 1	Mus musculus	169-180
2012240-1	1991	Systemic treatment with capsaicin, a neurotoxin that destroys small unmyelinated primary sensory neurons, causes degeneration of vagal sensory fibers and attenuates suppression of sham feeding by exogenous cholecystokinin (CCK) or intraintestinally infused nutrients.	Capsaicin	24-33	cholecystokinin	Rattus norvegicus	223-226
2012240-3	1991	Capsaicin treatment abolished the suppression of sham feeding induced by intraperitoneal injection of CCK octapeptide or by intraintestinal maltose.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	102-105
2012240-6	1991	These results indicate that capsaicin-sensitive substrates, located near the fourth ventricle, participate in the suppression of sham feeding by CCK and by some intestinal stimuli.	Capsaicin	28-37	cholecystokinin	Rattus norvegicus	145-148
1868882-4	1991	Neuropeptide Y (NPY) potentiated vasoconstrictor responses to transmural nerve stimulation, but suppressed capsaicin-sensitive vasodilation, an effect which was unaltered by indomethacin.	Capsaicin	107-116	neuropeptide Y	Rattus norvegicus	0-14
1868882-4	1991	Neuropeptide Y (NPY) potentiated vasoconstrictor responses to transmural nerve stimulation, but suppressed capsaicin-sensitive vasodilation, an effect which was unaltered by indomethacin.	Capsaicin	107-116	neuropeptide Y	Rattus norvegicus	16-19
1855123-6	1991	Capsaicin-pretreatment, two weeks earlier to deplete sensory neuropeptides from primary afferent neurones, augmented the mucosal damage induced by ET-1, as assessed by both macroscopic and histological examination.	Capsaicin	0-9	endothelin 1	Rattus norvegicus	147-151
1855123-8	1991	The damage induced by threshold doses of ET-1 alone or in capsaicin-pretreated rats was further enhanced by administration of indomethacin (5 mg kg-1, i.v.	Capsaicin	58-67	endothelin 1	Rattus norvegicus	41-45
1656616-3	1991	Capsaicin apparently works to release substance P from sensory nerve fibers and after repeated applications, depletes neurons of substance P.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	38-49
1656616-3	1991	Capsaicin apparently works to release substance P from sensory nerve fibers and after repeated applications, depletes neurons of substance P.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	129-140
2035338-3	1991	Systemic capsaicin treatment of the pig depletes the content of sensory neuropeptides (CGRP and tachykinins) in the airways mucosa and skin, without affecting sympathetic and parasympathetic nerves containing NPY and VIP, or the presence and appearance of inflammatory cells including mast cells.	Capsaicin	9-18	Calcitonin gene-related peptide	Sus scrofa	87-91
1713399-5	1991	The vasodilatory effect of capsaicin, except the laser-Doppler signal, was markedly reduced by pretreatment with a combination of the ganglionic blocking agent chlorisondamine and atropine implying that capsaicin evokes a central reflex with a final parasympathetic pathway and release of agents like vasoactive intestinal polypeptide.	Capsaicin	203-212	vasoactive intestinal peptide	Sus scrofa	301-334
1991072-3	1991	CGRP immunoreactivity was localized in capsaicin-sensitive nerve fibers and in capsaicin-nonsensitive endocrine cells occurring singly or in groups.	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
1991072-3	1991	CGRP immunoreactivity was localized in capsaicin-sensitive nerve fibers and in capsaicin-nonsensitive endocrine cells occurring singly or in groups.	Capsaicin	79-88	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
1707713-6	1991	Exposure to capsaicin evoked a clear-cut increase in CGRP-LI outflow, suggesting release from isolated large specimen of the LAD.	Capsaicin	12-21	calcitonin related polypeptide alpha	Homo sapiens	53-57
1707713-17	1991	It is concluded that CGRP-LI is present in human cardiopulmonary tissue and can be released upon exposure to high concentrations of capsaicin as well as potassium.	Capsaicin	132-141	calcitonin related polypeptide alpha	Homo sapiens	21-25
1707713-18	1991	CGRP causes relaxation of arteries independently of EDRF activation and closely resembles the vasodilator effects of capsaicin.	Capsaicin	117-126	calcitonin related polypeptide alpha	Homo sapiens	0-4
1707713-20	1991	Ruthenium red inhibits capsaicin-induced CGRP-LI release and functional effects and may thus serve as an experimental tool in evaluating the function of capsaicin-evoked stimulation of peripheral nerve terminals.	Capsaicin	23-32	calcitonin related polypeptide alpha	Homo sapiens	41-45
2040366-2	1991	In addition, hCGRP-(8-37) reduced the responses produced by activation of the "efferent" function of capsaicin-sensitive primary afferents in both preparations thus providing pharmacological evidence for the involvement of endogenous CGRP.	Capsaicin	101-110	calcitonin related polypeptide alpha	Homo sapiens	13-18
2040366-2	1991	In addition, hCGRP-(8-37) reduced the responses produced by activation of the "efferent" function of capsaicin-sensitive primary afferents in both preparations thus providing pharmacological evidence for the involvement of endogenous CGRP.	Capsaicin	101-110	calcitonin related polypeptide alpha	Homo sapiens	14-18
1683092-8	1991	Mainly sensory axon reflex mechanisms occurred upon systemic capsaicin injection in the pig after pretreatment with a combination of autonomic blocking agents, as revealed by plasma elevations of CGRP- and NKA-LI but not NPY-LI or catecholamines.	Capsaicin	61-70	Calcitonin gene-related peptide	Sus scrofa	196-200
1683092-9	1991	Repeated capsaicin injections, in the presence of autonomic blocking agents, caused a marked reduction in the elevation of plasma CGRP- and NKA-LI with a clear-cut fall in the bronchial vascular response, suggesting development of tachyphylaxis for local sensory mechanisms.	Capsaicin	9-18	Calcitonin gene-related peptide	Sus scrofa	130-134
1683092-15	1991	SP and CGRP mimicked capsaicin-induced vasodilatation in the laryngo-tracheal and bronchial circulations.	Capsaicin	21-30	Calcitonin gene-related peptide	Sus scrofa	7-11
1719774-4	1991	Pretreatment with the selective sensory neurotoxin capsaicin induced CGRP-li decrease in the duodenum, which was not further decreased by an ulcerogenic dose of cysteamine, indicating that cysteamine induced a release of CGRP-li of capsaicin-sensitive origin.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	69-73
1719774-4	1991	Pretreatment with the selective sensory neurotoxin capsaicin induced CGRP-li decrease in the duodenum, which was not further decreased by an ulcerogenic dose of cysteamine, indicating that cysteamine induced a release of CGRP-li of capsaicin-sensitive origin.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	221-225
1719774-4	1991	Pretreatment with the selective sensory neurotoxin capsaicin induced CGRP-li decrease in the duodenum, which was not further decreased by an ulcerogenic dose of cysteamine, indicating that cysteamine induced a release of CGRP-li of capsaicin-sensitive origin.	Capsaicin	232-241	calcitonin-related polypeptide alpha	Rattus norvegicus	221-225
1364846-15	1991	CGRP-LI outflow induced by FMLP was blocked by indomethacin or in vitro capsaicin pretreatment.	Capsaicin	72-81	calcitonin related polypeptide alpha	Homo sapiens	0-4
1709747-5	1991	The depletion of substance P-immunoreactivity(-IR) and calcitonin gene-related peptide(CGRP)-IR in extracts of urinary bladder and lung from the capsaicin-treated rats is evidence of the efficacy of capsaicin treatment in affecting a loss of C-fibre sensory nerves.	Capsaicin	145-154	calcitonin-related polypeptide alpha	Rattus norvegicus	87-91
1709747-6	1991	The significant depletion of CGRP-IR measured in the stomach and duodenum of capsaicin-treated rats indicated the loss of the C-fibre sensory innervation to the gastrointestinal tract.	Capsaicin	77-86	calcitonin-related polypeptide alpha	Rattus norvegicus	29-33
1950424-8	1991	Capsaicin treatment significantly reduced the density of AChE-positive nerve fibres in knee joint ligaments but did not affect nerve fibres in the articular capsule.	Capsaicin	0-9	acetylcholinesterase	Rattus norvegicus	57-61
1891972-2	1991	Co-localization of SP and CGRP was observed in a dense intraepithelial and perivascular network of capsaicin-sensitive sensory nerves in the nasal mucosa of different species, including man.	Capsaicin	99-108	calcitonin related polypeptide alpha	Homo sapiens	26-30
1950784-12	1991	The release of CGRP from spinal afferents innervating the stomach in response to stimulation of capsaicin-sensitive fibers suggests a role of the peptide in the regulation of gastric function.	Capsaicin	96-105	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
2035338-3	1991	Systemic capsaicin treatment of the pig depletes the content of sensory neuropeptides (CGRP and tachykinins) in the airways mucosa and skin, without affecting sympathetic and parasympathetic nerves containing NPY and VIP, or the presence and appearance of inflammatory cells including mast cells.	Capsaicin	9-18	vasoactive intestinal peptide	Sus scrofa	217-220
1952629-9	1991	We now aim at providing direct pharmacological evidence that antagonism of endogenously released CGRP results in similar pathophysiological consequences as ablation of capsaicin-sensitive sensory neurons.	Capsaicin	168-177	calcitonin-related polypeptide alpha	Rattus norvegicus	97-101
1724137-0	1991	Capsaicin-induced c-fos in peripheral nervous system glial cells.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-23
1724990-10	1991	Pretreatment of the skin with capsaicin (1% alcoholic solution) for 2 or 3 days markedly reduced the histamine- or substance P-induced blood flow increase.	Capsaicin	30-39	tachykinin precursor 1	Homo sapiens	115-126
1851542-7	1991	The tissue content of CGRP and NKA was reduced by 50-65% in the airways and by 80-90% in the skin 2 days after capsaicin pretreatment.	Capsaicin	111-120	Calcitonin gene-related peptide	Sus scrofa	22-26
1990233-3	1991	Capsaicin pretreatment (50 + 100 mg kg-1 in two days) markedly decreased gastric CGRP-li in both sham and SALX-operated rats and increased acid concentration and output only in SALX animals.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	81-85
1674126-0	1991	Serotonin, but neither noradrenaline nor GABA, inhibits capsaicin-evoked release of immunoreactive somatostatin from slices of rat spinal cord.	Capsaicin	56-65	somatostatin	Rattus norvegicus	99-111
1674126-2	1991	In the present experiments, to elucidate neural systems inhibiting the release of somatostatin from the primary afferent terminals, we examined the effects of serotonin, noradrenaline and gamma-aminobutyric acid on the capsaicin-evoked, dorsal-rhizotomy-sensitive and tetrodotoxin-insensitive release of immunoreactive somatostatin, 98.7% of which was somatostatin itself, from the dorsal-half slices of lumbar and cervical enlargements of rat spinal cord.	Capsaicin	219-228	somatostatin	Rattus norvegicus	82-94
1709520-4	1991	Capsaicin, a homovanillic acid derivative that acts as a releaser of SP from primary afferent neurons, caused a strong stimulation of collagenase production and release at 10(-8) and 10(-6) M (about 7 times the amount of the control).	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	69-71
1703620-6	1991	In other studies, saline insoluble capsaicin is administered in 25% dimethylsulfoxide (DMSO) or 20% CDEX (15 microliters; 5 mg/ml) which result in a significant reduction in the spinal levels of substance P and calcitonin gene related peptide and an increase in the HP latency.	Capsaicin	35-44	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	100-104
2081812-2	1990	Animals treated neonatally with capsaicin display reduced preproenkephalin gene expression in nucleus caudalis neurons.	Capsaicin	32-41	proenkephalin	Homo sapiens	58-74
2081812-4	1990	High intensity stimulation is effective only at later time points in normal animals, but it causes both early and late effects on preproenkephalin expression when applied to animals neonatally lesioned with capsaicin.	Capsaicin	207-216	proenkephalin	Homo sapiens	130-146
2124338-3	1990	Local capsaicin application to the nerve trunk failed to inhibit the injury-induced VIP increase, and capsaicin even increased VIP levels when applied locally to uninjured nerves.	Capsaicin	102-111	vasoactive intestinal peptide	Rattus norvegicus	127-130
2034830-8	1991	Bronchodilation following capsaicin inhalation has been observed in HLT recipients, and may be due to unopposed release of VIP from retained post-ganglionic efferent nerves.	Capsaicin	26-35	vasoactive intestinal peptide	Homo sapiens	123-126
2093150-8	1990	Reported data suggested that the CCKLI material present in capsaicin-sensitive neurons, accounting for only about 10% of radioimmunoassayable CCKLI but for a much higher proportion of that detected in IC, was distinct from both genuine CCK and CGRP.	Capsaicin	59-68	cholecystokinin	Rattus norvegicus	33-36
2093150-8	1990	Reported data suggested that the CCKLI material present in capsaicin-sensitive neurons, accounting for only about 10% of radioimmunoassayable CCKLI but for a much higher proportion of that detected in IC, was distinct from both genuine CCK and CGRP.	Capsaicin	59-68	calcitonin-related polypeptide alpha	Rattus norvegicus	244-248
2087441-3	1990	Sensory denervation (capsaicin treatment) of adult guinea pigs caused an almost total disappearance of CGRP- and SP-containing nerve fibers, while the density of VIP-containing nerve fibers located in smooth muscle seemed to increase.	Capsaicin	21-30	VIP peptides	Cavia porcellus	162-165
2076156-2	1990	Thus extravasation of plasma proteins is evoked by local release of peptides such as substance P (SP) from capsaicin-sensitive sensory nerves upon inhalation of cigarette smoke.	Capsaicin	107-116	tachykinin precursor 1	Homo sapiens	85-96
2076156-2	1990	Thus extravasation of plasma proteins is evoked by local release of peptides such as substance P (SP) from capsaicin-sensitive sensory nerves upon inhalation of cigarette smoke.	Capsaicin	107-116	tachykinin precursor 1	Homo sapiens	98-100
2076156-3	1990	Calcitonin gene-related peptide (CGRP) is another vasodilator agent which is also released from airway afferent nerves by capsaicin or antidromic nerve stimulation.	Capsaicin	122-131	calcitonin related polypeptide alpha	Homo sapiens	0-31
2076156-3	1990	Calcitonin gene-related peptide (CGRP) is another vasodilator agent which is also released from airway afferent nerves by capsaicin or antidromic nerve stimulation.	Capsaicin	122-131	calcitonin related polypeptide alpha	Homo sapiens	33-37
1709479-6	1990	Thus, NPY exerts a powerful inhibitory action on tachykinin release from peripheral endings of capsaicin-sensitive airway sensory nerves, but has no effect on the i-NANC neural mechanisms.	Capsaicin	95-104	pro-neuropeptide Y	Cavia porcellus	6-9
2221491-0	1990	Topical capsaicin induces cough in patient receiving ACE inhibitor.	Capsaicin	8-17	angiotensin I converting enzyme	Homo sapiens	53-56
1697886-4	1990	Rhizotomy-induced CGRP depletion (-85%) within the ipsilateral dorsal zone of the cervical cord was more pronounced than that due to neonatal capsaicin (-60%), a finding suggesting that this peptide is contained in both capsaicin-sensitive (mostly unmyelinated) and -insensitive (myelinated) primary afferent fibers.	Capsaicin	220-229	calcitonin-related polypeptide alpha	Rattus norvegicus	18-22
2271930-5	1990	Splanchnic sensory neurons containing CaBP were sensitive to capsaicin while cutaneous ones were not.	Capsaicin	61-70	S100 calcium binding protein G	Rattus norvegicus	38-42
2253692-11	1990	We conclude that authentic VIP is involved in the local motor response to capsaicin in the human small intestine.	Capsaicin	74-83	vasoactive intestinal peptide	Homo sapiens	27-30
1703663-0	1990	[Effect of capsaicin on the release of substance P from spinal cord and blood pressure].	Capsaicin	11-20	tachykinin precursor 1	Homo sapiens	39-50
1703663-2	1990	Intrathecal injection(ith) of capsaicin caused a release of SP from the spinal cord and resulted in an increase in blood pressure and heart rate accompanied by an elevation of plasma adrenaline and noradrenaline.	Capsaicin	30-39	tachykinin precursor 1	Homo sapiens	60-62
1703663-4	1990	The immunohistochemical study showed that the SP-like immunoreactivity in T-8 of the spinal cord was decreased as the amount of capsaicin administrated was increased.	Capsaicin	128-137	tachykinin precursor 1	Homo sapiens	46-48
1703316-0	1990	Capsaicin-sensitive nerves influence the release of atrial natriuretic factor by atrial stretch in the rat.	Capsaicin	0-9	natriuretic peptide A	Rattus norvegicus	52-77
1703316-3	1990	We have examined the influence of chronic capsaicin treatment on three models of atrial stretch that release ANF.	Capsaicin	42-51	natriuretic peptide A	Rattus norvegicus	109-112
1703316-6	1990	We conclude that capsaicin-sensitive cardiac innervation is a component modulating the release of ANF, stimulated by atrial stretch in the rat.	Capsaicin	17-26	natriuretic peptide A	Rattus norvegicus	98-101
1701233-3	1990	We propose that capsaicin may be a useful treatment for reflex sympathetic dystrophy, either by depleting substance P from primary afferent neurons that mediate allodynia, or by modulating sympathetic efferent activity.	Capsaicin	16-25	tachykinin precursor 1	Homo sapiens	106-117
2253692-0	1990	Direct evidence for the involvement of vasoactive intestinal polypeptide in the motor response of the human isolated ileum to capsaicin.	Capsaicin	126-135	vasoactive intestinal peptide	Homo sapiens	39-72
2253692-5	1990	All the effects of capsaicin in the longitudinal and circular muscle were closely mimicked by exogenous vasoactive intestinal polypeptide (VIP).	Capsaicin	19-28	vasoactive intestinal peptide	Homo sapiens	104-137
2253692-5	1990	All the effects of capsaicin in the longitudinal and circular muscle were closely mimicked by exogenous vasoactive intestinal polypeptide (VIP).	Capsaicin	19-28	vasoactive intestinal peptide	Homo sapiens	139-142
2253692-6	1990	Further, the inhibitory motor effect of capsaicin in both muscle layers was blocked by an anti VIP serum.	Capsaicin	40-49	vasoactive intestinal peptide	Homo sapiens	95-98
1710041-1	1990	In high K(+)-depolarized spinal cord slices, capsaicin evoked the in vitro release of substance P and calcitonin gene-related peptide (CGRP) from central terminals of C-fibre afferents.	Capsaicin	45-54	tachykinin precursor 1	Homo sapiens	86-97
1710041-1	1990	In high K(+)-depolarized spinal cord slices, capsaicin evoked the in vitro release of substance P and calcitonin gene-related peptide (CGRP) from central terminals of C-fibre afferents.	Capsaicin	45-54	calcitonin related polypeptide alpha	Homo sapiens	102-133
1710041-1	1990	In high K(+)-depolarized spinal cord slices, capsaicin evoked the in vitro release of substance P and calcitonin gene-related peptide (CGRP) from central terminals of C-fibre afferents.	Capsaicin	45-54	calcitonin related polypeptide alpha	Homo sapiens	135-139
2253692-9	1990	Capsaicin (1 microM) evoked a tetrodotoxin-resistant release of VIP-like immunoreactivity from the human small intestine.	Capsaicin	0-9	vasoactive intestinal peptide	Homo sapiens	64-67
2253692-10	1990	On high pressure liquid chromatography, a major peak of the immunoreactive material released by capsaicin co-eluted with authentic VIP and a minor, unidentified peak eluted shortly afterward.	Capsaicin	96-105	vasoactive intestinal peptide	Homo sapiens	131-134
2253692-12	1990	These findings raise the possibility that VIP might be present in sensory nerves of the human gut from which it is released by capsaicin.	Capsaicin	127-136	vasoactive intestinal peptide	Homo sapiens	42-45
2386244-1	1990	Interscapular brown adipose tissue (BAT) of capsaicin-desensitized (Cap-Des) rats is atrophied, having a lower wet weight, a reduced total protein content, and as little as 10% of the normal content of uncoupling protein (UCP).	Capsaicin	44-53	uncoupling protein 1	Rattus norvegicus	222-225
1697742-0	1990	Effect of capsaicin on the release of substance P from rheumatoid arthritis and osteoarthritis synoviocytes in vitro.	Capsaicin	10-19	tachykinin precursor 1	Homo sapiens	38-49
1697196-17	1990	In conclusion, ACE inhibitors potentiate the BC induced by substance P and, to a minor extent, that induced by capsaicin in the anaesthetized guinea-pig.	Capsaicin	111-120	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	15-18
2113415-2	1990	After capsaicin treatment, a striking expansion in the latter population was seen (L2: 22.0%) together with a significant increase in size, restricted to the same population and the (remaining) peripherin-only immunoreactive neurons.	Capsaicin	6-15	peripherin	Rattus norvegicus	194-204
1700308-3	1990	Anti-CGRP (calcitonin gene-related peptide) serum blocked the epithelium-dependent potentiation of the capsaicin-induced contraction in the intact tracheal strips, without affecting the response of the epithelium-free strips.	Capsaicin	103-112	calcitonin-related polypeptide alpha	Rattus norvegicus	5-9
1700308-6	1990	In epithelium-free tracheal strips, capsaicin-induced contraction was abolished by spantide (10(-6) and 10(-5) M), a substance P antagonist, but, in intact tracheal strips, spantide did not abolish the capsaicin-induced contraction, showing that both CGRP and substance P release are directly induced by capsaicin.	Capsaicin	36-45	calcitonin-related polypeptide alpha	Rattus norvegicus	251-255
2122423-0	1990	Capsaicin-sensitive vagal afferents contribute to gastric acid and vascular responses to intracisternal TRH analog.	Capsaicin	0-9	thyrotropin releasing hormone	Rattus norvegicus	104-107
2122423-6	1990	The mechanism by which vagal afferent fibers contribute to the secretory and blood flow responses to the stable TRH analog is unclear at present, but it is possible that the decrease in gastric mucosal blood flow by lesion of capsaicin-sensitive vagal afferents limits the secretory response.	Capsaicin	226-235	thyrotropin releasing hormone	Rattus norvegicus	112-115
2113415-3	1990	Calcitonin gene-related peptide (CGRP) immunoreactivity was revealed in neurons of all 3 groups, in both normal and capsaicin-treated rats.	Capsaicin	116-125	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
2113415-3	1990	Calcitonin gene-related peptide (CGRP) immunoreactivity was revealed in neurons of all 3 groups, in both normal and capsaicin-treated rats.	Capsaicin	116-125	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
2359517-0	1990	Release of calcitonin gene-related peptide (CGRP) from capsaicin-sensitive vasodilator nerves in the rat mesenteric artery.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	11-42
2359517-0	1990	Release of calcitonin gene-related peptide (CGRP) from capsaicin-sensitive vasodilator nerves in the rat mesenteric artery.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
1694670-7	1990	Following neonatal capsaicin treatment, CGRP- and SP-containing fibres in the buccal mucosa almost totally disappeared, but many CGRP-IR fibres remained in the incisor tooth pulp.	Capsaicin	19-28	calcitonin-related polypeptide alpha	Rattus norvegicus	40-44
2359517-1	1990	The effect of perivascular nerve stimulation (PNS) and capsaicin treatment on the release of calcitonin gene-related peptide (CGRP) was examined by radioimmunoassay (RIA) in isolated, perfused rat mesenteric arteries.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	93-124
2359517-1	1990	The effect of perivascular nerve stimulation (PNS) and capsaicin treatment on the release of calcitonin gene-related peptide (CGRP) was examined by radioimmunoassay (RIA) in isolated, perfused rat mesenteric arteries.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	126-130
2359517-2	1990	In the preparation precontracted by methoxamine and treated with guanethidine, an adrenergic neuron blocker, PNS and capsaicin induced vasodilator responses and increase of CGRP-like immunoreactivity (CGRP-LI) in the perfusate in a frequency-dependent manner.	Capsaicin	117-126	calcitonin-related polypeptide alpha	Rattus norvegicus	173-177
2359517-2	1990	In the preparation precontracted by methoxamine and treated with guanethidine, an adrenergic neuron blocker, PNS and capsaicin induced vasodilator responses and increase of CGRP-like immunoreactivity (CGRP-LI) in the perfusate in a frequency-dependent manner.	Capsaicin	117-126	calcitonin-related polypeptide alpha	Rattus norvegicus	201-205
2359517-3	1990	The CGRP-LI released by capsaicin was identified as CGRP and its oxidized form by high-performance liquid chromatography coupled with RIA.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	4-8
2359517-3	1990	The CGRP-LI released by capsaicin was identified as CGRP and its oxidized form by high-performance liquid chromatography coupled with RIA.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	52-56
2359517-5	1990	These findings suggest that CGRP plays a neurotransmitter role in capsaicin-sensitive vasodilator nerves in rat mesenteric arteries.	Capsaicin	66-75	calcitonin-related polypeptide alpha	Rattus norvegicus	28-32
1694670-7	1990	Following neonatal capsaicin treatment, CGRP- and SP-containing fibres in the buccal mucosa almost totally disappeared, but many CGRP-IR fibres remained in the incisor tooth pulp.	Capsaicin	19-28	calcitonin-related polypeptide alpha	Rattus norvegicus	129-133
1692106-4	1990	Capsaicin (10 microM): a) contracted the isolated sphincter muscle and; b) released immunoreactivity for substance P (SP-LI) and CGRP (CGRP-LI) from this preparation.	Capsaicin	0-9	Calcitonin gene-related peptide	Sus scrofa	129-133
2199947-0	1990	Relative sparing of calcitonin gene-related peptide-containing primary sensory neurons following neonatal capsaicin treatment in the rat.	Capsaicin	106-115	calcitonin-related polypeptide alpha	Rattus norvegicus	20-51
2199947-1	1990	Calcitonin gene-related peptide (CGRP)-containing sensory neurons projecting to viscera or skin were detected by immunocytochemistry combined with fluorescent tracer in the dorsal root ganglia (Th9-10) of rats 5-6 weeks old treated neonatally with capsaicin.	Capsaicin	248-257	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
2199947-1	1990	Calcitonin gene-related peptide (CGRP)-containing sensory neurons projecting to viscera or skin were detected by immunocytochemistry combined with fluorescent tracer in the dorsal root ganglia (Th9-10) of rats 5-6 weeks old treated neonatally with capsaicin.	Capsaicin	248-257	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
2199947-2	1990	The number of CGRP-like immunoreactive (IR) cells were reduced by 50-60% with capsaicin treatment.	Capsaicin	78-87	calcitonin-related polypeptide alpha	Rattus norvegicus	14-18
1693868-8	1990	Capsaicin induced a loss of CGRP- and tachykinin-immunoreactive ganglion cells and of CGRP, tachykinin or galanin immunoreactivity from the dorsal horn.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	28-32
1693868-8	1990	Capsaicin induced a loss of CGRP- and tachykinin-immunoreactive ganglion cells and of CGRP, tachykinin or galanin immunoreactivity from the dorsal horn.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
1692106-4	1990	Capsaicin (10 microM): a) contracted the isolated sphincter muscle and; b) released immunoreactivity for substance P (SP-LI) and CGRP (CGRP-LI) from this preparation.	Capsaicin	0-9	Calcitonin gene-related peptide	Sus scrofa	135-142
1691575-2	1990	Ten days after capsaicin treatment immunocytochemical investigations showed a nearly complete disappearance of substance P (SP) and calcitonin gene-related peptide (CGRP) in all parts of the bladder.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	132-163
1691946-0	1990	Suppression by neuropeptide Y of capsaicin-sensitive sensory nerve-mediated contraction in guinea-pig airways.	Capsaicin	33-42	pro-neuropeptide Y	Cavia porcellus	15-29
1691948-0	1990	A bradykinin (BK)1 receptor antagonist blocks capsaicin-induced ear inflammation in mice.	Capsaicin	46-55	bradykinin receptor, beta 1	Mus musculus	2-27
1691948-4	1990	Co-administration of the substance P (SP) antagonist [D-Pro2,D-Trp7,9]SP at 100 and 300 micrograms per ear with capsaicin markedly attenuated oedema, whereas a vasopressin antagonist was ineffective.	Capsaicin	112-121	tachykinin 1	Mus musculus	25-36
1691948-12	1990	These results suggest that BK1 along with BK2 receptors are located on capsaicin-sensitive fibres, where they may modulate the degree of neurogenic inflammation.	Capsaicin	71-80	bradykinin receptor, beta 2	Mus musculus	42-45
2316650-1	1990	Capsaicin pretreatment, which destroys primary sensory afferent neurons, or morphine, which can inhibit peripheral sensory neurons, augments gastric damage induced by platelet-activating factor (PAF).	Capsaicin	0-9	PCNA clamp associated factor	Rattus norvegicus	167-193
1691575-2	1990	Ten days after capsaicin treatment immunocytochemical investigations showed a nearly complete disappearance of substance P (SP) and calcitonin gene-related peptide (CGRP) in all parts of the bladder.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	165-169
2109845-2	1990	Subcutaneous injection of 50 mg/kg capsaicin potently induced c-fos in the spinal cord on the first postnatal day (P1), whilst plantar injection of dilute formalin was much less effective until P3.	Capsaicin	35-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	62-67
1964391-0	1990	Capsaicin inhibits calmodulin-mediated oxidative burst in rat macrophages.	Capsaicin	0-9	calmodulin 1	Rattus norvegicus	19-29
1690290-0	1990	Administration of recombinant enkephalinase (neutral endopeptidase) prevents capsaicin-induced miosis in the rabbit eye in vivo.	Capsaicin	77-86	neprilysin	Oryctolagus cuniculus	30-43
1690290-2	1990	Pretreatment of the iris with 20 micrograms of recombinant enkephalinase (neutral endopeptidase; EC 3.4.24.11) totally abolished the contractile response to substance P. Injection of 10 micrograms of capsaicin into the anterior chamber of atropine-treated rabbit eyes in vivo induced an immediate and intense miosis.	Capsaicin	200-209	neprilysin	Oryctolagus cuniculus	59-72
1690290-3	1990	Injection of 100 micrograms of recombinant enkephalinase, 1 or 5 min before capsaicin injection, significantly inhibited this miosis.	Capsaicin	76-85	neprilysin	Oryctolagus cuniculus	43-56
1964391-1	1990	In this study we seek to elucidate the interaction of capsaicin with the calmodulin mediated signal pathways in macrophages, by comparing its action on macrophage functions with a known calmodulin antagonist, fluphenazine.	Capsaicin	54-63	calmodulin 1	Rattus norvegicus	73-83
1964391-1	1990	In this study we seek to elucidate the interaction of capsaicin with the calmodulin mediated signal pathways in macrophages, by comparing its action on macrophage functions with a known calmodulin antagonist, fluphenazine.	Capsaicin	54-63	calmodulin 1	Rattus norvegicus	186-196
1964391-3	1990	Ca2+ ionophore triggered generation of superoxide anion and hydrogen peroxide by macrophages was inhibited in a dose-dependent manner by fluphenazine (IC50, 20 microM and 12 microM, respectively) and also by capsaicin (IC50, 30 microM and 9 microM, respectively), suggesting an involvement of calmodulin in the regulation of NADPH oxidase.	Capsaicin	208-217	calmodulin 1	Rattus norvegicus	293-303
1964391-4	1990	In vitro both fluphenazine and capsaicin inhibited Ca2(+)-Mg2+ ATPase and cAMP-phosphodiesterase from macrophages and this inhibition was reversed by exogenous addition of calmodulin.	Capsaicin	31-40	calmodulin 1	Rattus norvegicus	172-182
1964391-5	1990	Fluorescence studies revealed a direct Ca2+ dependent interaction of capsaicin with calmodulin.	Capsaicin	69-78	calmodulin 1	Rattus norvegicus	84-94
1964391-6	1990	From these results we suggest that capsaicin acts via calmodulin to inhibit stimulus-induced macrophage oxidative burst and also that calmodulin regulates the oxidative burst in macrophages.	Capsaicin	35-44	calmodulin 1	Rattus norvegicus	54-64
2139720-10	1990	In investigating the mechanism of GAP-43 regulation, blockade of axon transport in the sciatic nerve with vinblastine (10(-5) M-10(-4) M) or capsaicin (1.5%) was found to produce a pattern of GAP-43 immunoreactivity in the dorsal horn identical to that found with crush, while electrical stimulation of the sciatic nerve had no effect.	Capsaicin	141-150	growth associated protein 43	Rattus norvegicus	34-40
1689282-8	1990	3) Nasal mucosa: intranasal application of capsaicin, a powerful releaser of SP from sensory terminals, evokes an immediate burning pain in the ipsilateral nasal, ocular, and temporal areas, as well as lacrimation and rhinorrhea.	Capsaicin	43-52	tachykinin precursor 1	Homo sapiens	77-79
2139720-10	1990	In investigating the mechanism of GAP-43 regulation, blockade of axon transport in the sciatic nerve with vinblastine (10(-5) M-10(-4) M) or capsaicin (1.5%) was found to produce a pattern of GAP-43 immunoreactivity in the dorsal horn identical to that found with crush, while electrical stimulation of the sciatic nerve had no effect.	Capsaicin	141-150	growth associated protein 43	Rattus norvegicus	192-198
2125862-9	1990	The SP-LI, ENK-LI and FRAP were all weakened in dorsal horn of spinal cord 1h after capsaicin treatment.	Capsaicin	84-93	proenkephalin	Rattus norvegicus	11-14
2125862-11	1990	The foregoing results indicated that the metabolism and function of C fibers of primary afferent especially the SP containing nerve and those of ENK-containing neurons could be influenced by the extradural injection of capsaicin.	Capsaicin	219-228	proenkephalin	Rattus norvegicus	145-148
33811839-8	2021	The pain score and c-fos expression in the spinal cord were highest in the 0.9 mg capsaicin group and lowest in the normal saline and vehicle groups (P < 0.05).	Capsaicin	82-91	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	19-24
33819369-8	2021	Similarly, TRPV1 agonist capsaicin did not activate primary mouse cardiomyocytes, did not alter electrically paced activity in these, and did not activate H9c2 cells or alter spontaneous activity of HL-1 cells.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	11-16
33806914-5	2021	The obtained results revealed that curcumin, 6-gingerol, capsaicin, and resveratrol represent potential PDE4D inhibitors; however, the predicted binding free energies of 6-gingerol, capsaicin, and resveratrol were less negative than in the case of curcumin, which exhibited the highest inhibitory potency in comparison with a positive control rolipram.	Capsaicin	57-66	phosphodiesterase 4D	Homo sapiens	104-109
2304629-0	1990	Release of calcitonin gene-related peptide induced by capsaicin in the vascularly perfused rat stomach.	Capsaicin	54-63	calcitonin-related polypeptide alpha	Rattus norvegicus	11-42
2304629-1	1990	It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	135-166
2304629-1	1990	It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	168-172
2304629-1	1990	It has been suggested that capsaicin-induced gastric mucosal protection results from the local release of vasodilator peptides such as calcitonin gene-related peptide (CGRP) from afferent nerve endings within the stomach, since CGRP is able to reduce gastric lesion formation.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	228-232
2304629-2	1990	This concept is supported by the present finding that capsaicin (10(-5) M), administered to the vascularly perfused stomach of the rat, produces a more than 30-fold rise of the CGRP content of the venous effluent.	Capsaicin	54-63	calcitonin-related polypeptide alpha	Rattus norvegicus	177-181
33766560-1	2021	Regulation of the heat- and capsaicin-activated Transient Receptor Potential Vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-88
33766560-1	2021	Regulation of the heat- and capsaicin-activated Transient Receptor Potential Vanilloid 1 (TRPV1) channel by phosphoinositides is complex and controversial.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	90-95
33766560-2	2021	In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinositides were proposed to act as competitive vanilloid antagonists.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-24
33766560-2	2021	In the most recent TRPV1 cryo-EM structure, endogenous phosphatidylinositol (PtdIns) was detected in the vanilloid binding site, and phosphoinositides were proposed to act as competitive vanilloid antagonists.	Capsaicin	187-196	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-24
33766560-8	2021	The I703A mutant of TRPV1 showed increased sensitivity to capsaicin, as expected when removing the effect of an endogenous competitive antagonist.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
33806914-9	2021	The uncovered molecular inhibitory mechanisms of four investigated natural polyphenols, curcumin, 6-gingerol, capsaicin, and resveratrol, form the basis for the design of novel PDE4D inhibitors for the treatment of Alzheimer"s disease with a potentially wider therapeutic window and fewer adverse side effects.	Capsaicin	110-119	phosphodiesterase 4D	Homo sapiens	177-182
33799960-0	2021	Effect of Aging, Gender and Sensory Stimulation of TRPV1 Receptors with Capsaicin on Spontaneous Swallowing Frequency in Patients with Oropharyngeal Dysphagia: A Proof-of-Concept Study.	Capsaicin	72-81	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
33799960-8	2021	Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 +- 0.32 swallows/min vs post-capsaicin: 0.81 +- 0.51 swallow/min; p = 0.0003).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
33799960-8	2021	Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 +- 0.32 swallows/min vs post-capsaicin: 0.81 +- 0.51 swallow/min; p = 0.0003).	Capsaicin	125-134	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
33799960-8	2021	Capsaicin caused a strong and significant increase in SSF after the TRPV1 stimulation when comparing to basal condition (pre-capsaicin: 0.41 +- 0.32 swallows/min vs post-capsaicin: 0.81 +- 0.51 swallow/min; p = 0.0003).	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
33806699-0	2021	Ca2+ Signalling Induced by NGF Identifies a Subset of Capsaicin-Excitable Neurons Displaying Enhanced Chemo-Nociception in Dorsal Root Ganglion Explants from Adult pirt-GCaMP3 Mouse.	Capsaicin	54-63	nerve growth factor	Mus musculus	27-30
33806699-2	2021	Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear.	Capsaicin	46-55	nerve growth factor	Mus musculus	0-19
33806699-2	2021	Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear.	Capsaicin	46-55	nerve growth factor	Mus musculus	21-24
33806699-2	2021	Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	37-42
33806699-2	2021	Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear.	Capsaicin	57-61	nerve growth factor	Mus musculus	0-19
33806699-2	2021	Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear.	Capsaicin	57-61	nerve growth factor	Mus musculus	21-24
33806699-2	2021	Nerve growth factor (NGF) sensitises TRPV1 to capsaicin (CAPS), modulates nociceptor excitability and induces thermal hyperalgesia, but cellular mechanisms remain unclear.	Capsaicin	57-61	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	37-42
33591238-8	2021	Capsaicin, the agonist of transient receptor potential vanilloid type 1 (TRPV1), could selectively activate TRPV1, inducing Ca2+ influx and related signaling pathways.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-71
33591238-8	2021	Capsaicin, the agonist of transient receptor potential vanilloid type 1 (TRPV1), could selectively activate TRPV1, inducing Ca2+ influx and related signaling pathways.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
33591238-8	2021	Capsaicin, the agonist of transient receptor potential vanilloid type 1 (TRPV1), could selectively activate TRPV1, inducing Ca2+ influx and related signaling pathways.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	108-113
33815096-1	2020	Background: Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via its receptor subtype 4 (SST4) without influencing endocrine functions.	Capsaicin	43-52	somatostatin receptor 4	Mus musculus	155-159
25848051-3	2015	Here we report that the capsaicin-evoked action potential could be induced by two components: a cation influx-mediated depolarization caused by TRPV1 activation and a subsequent anion efflux-mediated depolarization via activation of anoctamin 1 (ANO1), a calcium-activated chloride channel, resulting from the entry of calcium through TRPV1.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	144-149
33803867-5	2021	The effect on sperm migration on a 10 muM capsaicin gradient (CPS), a TRPV1 agonist, was then investigated.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
25848051-3	2015	Here we report that the capsaicin-evoked action potential could be induced by two components: a cation influx-mediated depolarization caused by TRPV1 activation and a subsequent anion efflux-mediated depolarization via activation of anoctamin 1 (ANO1), a calcium-activated chloride channel, resulting from the entry of calcium through TRPV1.	Capsaicin	24-33	anoctamin 1, calcium activated chloride channel	Mus musculus	233-244
25848051-3	2015	Here we report that the capsaicin-evoked action potential could be induced by two components: a cation influx-mediated depolarization caused by TRPV1 activation and a subsequent anion efflux-mediated depolarization via activation of anoctamin 1 (ANO1), a calcium-activated chloride channel, resulting from the entry of calcium through TRPV1.	Capsaicin	24-33	anoctamin 1, calcium activated chloride channel	Mus musculus	246-250
25848051-3	2015	Here we report that the capsaicin-evoked action potential could be induced by two components: a cation influx-mediated depolarization caused by TRPV1 activation and a subsequent anion efflux-mediated depolarization via activation of anoctamin 1 (ANO1), a calcium-activated chloride channel, resulting from the entry of calcium through TRPV1.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	335-340
25848051-5	2015	Capsaicin activated the chloride currents in an extracellular calcium-dependent manner in HEK293T cells expressing TRPV1 and ANO1.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	115-120
25848051-5	2015	Capsaicin activated the chloride currents in an extracellular calcium-dependent manner in HEK293T cells expressing TRPV1 and ANO1.	Capsaicin	0-9	anoctamin 1	Homo sapiens	125-129
25848051-6	2015	Similarly, in mouse dorsal root ganglion neurons, capsaicin-activated inward currents were inhibited significantly by a specific ANO1 antagonist, T16Ainh-A01 (A01), in the presence of a high concentration of EGTA but not in the presence of BAPTA [1,2-bis(o-aminophenoxy)ethane-N,N,N",N"-tetraacetic acid].	Capsaicin	50-59	anoctamin 1, calcium activated chloride channel	Mus musculus	129-133
23461032-5	2012	Sensitivity to capsaicin was shown in largest neurons in each population; neurons in experimental group had smaller cross-sectional area, particularly in group of TRPV1(+)-neurons.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	163-168
34774329-0	2022	Retraction notice to "Stimulation of sensory neurons by capsaicin increases tissue levels of IGF-I, thereby reducing reperfusion-induced apoptosis in mice" (Neuropharmacology, 52 (2007) 1303-1311).	Capsaicin	56-65	insulin-like growth factor 1	Mus musculus	93-98
22395410-2	2012	In this study, we report the effect of capsaicin on its receptor, transient receptor potential vanilloid 1 (TRPV1) cation channel, in preventing fatty liver formation.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	66-106
22395410-2	2012	In this study, we report the effect of capsaicin on its receptor, transient receptor potential vanilloid 1 (TRPV1) cation channel, in preventing fatty liver formation.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
22395410-4	2012	TRPV1 activation by capsaicin reduced lipid accumulation and triglyceride level in the liver from wild-type (WT) mice.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22395410-6	2012	Chronic dietary capsaicin increased the hepatic uncoupling protein 2 (UCP2) expression in WT but not in TRPV1(-/-) mice (P &lt; 0.01).	Capsaicin	16-25	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	70-74
17056180-5	2007	At P3, extracellular signal-regulated kinase (ERK) protein is present in the dorsal horn, but hindpaw capsaicin produced minimal ERK activation restricted to the fourth lumbar segment.	Capsaicin	102-111	Eph receptor B1	Rattus norvegicus	129-132
17056180-6	2007	At P21, capsaicin induced intense phosphoERK expression in the superficial dorsal horn throughout several lumbar segments, consistent with the spread of secondary hyperalgesia.	Capsaicin	8-17	KRAS proto-oncogene, GTPase	Rattus norvegicus	3-6
17056180-7	2007	Intrathecal administration of the MEK (ERK kinase) inhibitor PD98059 prevented mustard oil and capsaicin-induced secondary hyperalgesia at P21, but had no effect on primary hyperalgesia at P3 or P21.	Capsaicin	95-104	Eph receptor B1	Rattus norvegicus	39-42
17056180-7	2007	Intrathecal administration of the MEK (ERK kinase) inhibitor PD98059 prevented mustard oil and capsaicin-induced secondary hyperalgesia at P21, but had no effect on primary hyperalgesia at P3 or P21.	Capsaicin	95-104	KRAS proto-oncogene, GTPase	Rattus norvegicus	139-142
16442086-11	2006	The difference in the distribution pattern of pERK- and Fos protein-LI cells in the Vi/Vc zone suggests their differential temporal expression profiles after capsaicin.	Capsaicin	158-167	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-59
12231404-9	2002	In conclusion, our study demonstrates expression of PAR-2 in rat pancreatic acini as well as parotid acini and indicates that nitric oxide participates in the PAR-2-mediated in vivo secretion of pancreatic amylase, and, to a certain extent, of salivary amylase, although capsaicin-sensitive sensory neurons, known to be activated by PAR-2, are not involved in the evoked pancreatic or salivary amylase secretion.	Capsaicin	271-280	F2R like trypsin receptor 1	Rattus norvegicus	159-164
12231404-9	2002	In conclusion, our study demonstrates expression of PAR-2 in rat pancreatic acini as well as parotid acini and indicates that nitric oxide participates in the PAR-2-mediated in vivo secretion of pancreatic amylase, and, to a certain extent, of salivary amylase, although capsaicin-sensitive sensory neurons, known to be activated by PAR-2, are not involved in the evoked pancreatic or salivary amylase secretion.	Capsaicin	271-280	F2R like trypsin receptor 1	Rattus norvegicus	159-164
34862806-7	2022	In the thermal stimulation in animals injected with capsaicin, the compound showed antinociceptive effect by oral and intraplantar routes, besides to reducing the levels of TNF-alpha, IL-1beta and PGE2 in the paws previously administered with capsaicin.	Capsaicin	52-61	tumor necrosis factor	Mus musculus	173-182
34862806-7	2022	In the thermal stimulation in animals injected with capsaicin, the compound showed antinociceptive effect by oral and intraplantar routes, besides to reducing the levels of TNF-alpha, IL-1beta and PGE2 in the paws previously administered with capsaicin.	Capsaicin	52-61	interleukin 1 alpha	Mus musculus	184-192
34862806-7	2022	In the thermal stimulation in animals injected with capsaicin, the compound showed antinociceptive effect by oral and intraplantar routes, besides to reducing the levels of TNF-alpha, IL-1beta and PGE2 in the paws previously administered with capsaicin.	Capsaicin	243-252	tumor necrosis factor	Mus musculus	173-182
34862806-7	2022	In the thermal stimulation in animals injected with capsaicin, the compound showed antinociceptive effect by oral and intraplantar routes, besides to reducing the levels of TNF-alpha, IL-1beta and PGE2 in the paws previously administered with capsaicin.	Capsaicin	243-252	interleukin 1 alpha	Mus musculus	184-192
34891118-0	2022	Capsaicin inhibits HIF-1alpha accumulation through suppression of mitochondrial respiration in lung cancer cells.	Capsaicin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	19-29
34891118-5	2022	Under hypoxic conditions, capsaicin reduced the accumulation of HIF-1alpha protein and the expression of its target genes, including pyruvate dehydrogenase kinase 1 (PDK1) and glucose transporter 1 (GLUT1), with no effect on overall HIF-1alpha mRNA levels in the H1299 cells.	Capsaicin	26-35	hypoxia inducible factor 1 subunit alpha	Homo sapiens	64-74
34891118-5	2022	Under hypoxic conditions, capsaicin reduced the accumulation of HIF-1alpha protein and the expression of its target genes, including pyruvate dehydrogenase kinase 1 (PDK1) and glucose transporter 1 (GLUT1), with no effect on overall HIF-1alpha mRNA levels in the H1299 cells.	Capsaicin	26-35	pyruvate dehydrogenase kinase 1	Homo sapiens	133-164
34891118-5	2022	Under hypoxic conditions, capsaicin reduced the accumulation of HIF-1alpha protein and the expression of its target genes, including pyruvate dehydrogenase kinase 1 (PDK1) and glucose transporter 1 (GLUT1), with no effect on overall HIF-1alpha mRNA levels in the H1299 cells.	Capsaicin	26-35	pyruvate dehydrogenase kinase 1	Homo sapiens	166-170
34891118-5	2022	Under hypoxic conditions, capsaicin reduced the accumulation of HIF-1alpha protein and the expression of its target genes, including pyruvate dehydrogenase kinase 1 (PDK1) and glucose transporter 1 (GLUT1), with no effect on overall HIF-1alpha mRNA levels in the H1299 cells.	Capsaicin	26-35	solute carrier family 2 member 1	Homo sapiens	176-197
34891118-5	2022	Under hypoxic conditions, capsaicin reduced the accumulation of HIF-1alpha protein and the expression of its target genes, including pyruvate dehydrogenase kinase 1 (PDK1) and glucose transporter 1 (GLUT1), with no effect on overall HIF-1alpha mRNA levels in the H1299 cells.	Capsaicin	26-35	solute carrier family 2 member 1	Homo sapiens	199-204
34891118-6	2022	In addition, capsaicin increased intracellular oxygen levels by suppressing mitochondrial respiration, resulting in a reduction of HIF-1alpha accumulation.	Capsaicin	13-22	hypoxia inducible factor 1 subunit alpha	Homo sapiens	131-141
34929338-6	2022	By contrast, enhancement of TRPV1 expression accompanying capsaicin application, the specific TRPV1 agonists, markedly accelerated nerve cell damage, aggravated neuronal apoptosis, prompted nuclear translocation of NF-kappaB (p65), resulting in the reversion of EA pretreatment-evoked neuroprotective effect in MCAO rats.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	28-33
34929338-6	2022	By contrast, enhancement of TRPV1 expression accompanying capsaicin application, the specific TRPV1 agonists, markedly accelerated nerve cell damage, aggravated neuronal apoptosis, prompted nuclear translocation of NF-kappaB (p65), resulting in the reversion of EA pretreatment-evoked neuroprotective effect in MCAO rats.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	94-99
34929338-6	2022	By contrast, enhancement of TRPV1 expression accompanying capsaicin application, the specific TRPV1 agonists, markedly accelerated nerve cell damage, aggravated neuronal apoptosis, prompted nuclear translocation of NF-kappaB (p65), resulting in the reversion of EA pretreatment-evoked neuroprotective effect in MCAO rats.	Capsaicin	58-67	synaptotagmin 1	Rattus norvegicus	215-230
34964356-7	2022	The amelioration effect of capsaicin on OA-induced lipid accumulation was weakened after Bmal1-knockdown, demonstrating that the rhythmic expression of the circadian clock gene is involved in the regulation process of capsaicin in lipid metabolism.	Capsaicin	27-36	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	89-94
34964356-7	2022	The amelioration effect of capsaicin on OA-induced lipid accumulation was weakened after Bmal1-knockdown, demonstrating that the rhythmic expression of the circadian clock gene is involved in the regulation process of capsaicin in lipid metabolism.	Capsaicin	218-227	aryl hydrocarbon receptor nuclear translocator like	Homo sapiens	89-94
34808551-3	2022	Capsaicin, a dietary agonist of Transient receptor potential vanilloid 1 (TRPV1) channel, is reported to alleviate the complications of obesity.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	32-72
34808551-3	2022	Capsaicin, a dietary agonist of Transient receptor potential vanilloid 1 (TRPV1) channel, is reported to alleviate the complications of obesity.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	74-79
34808551-12	2022	Capsaicin, bacteria and the host mucus system seem to act in a cyclic cascade involving TRPV1, which can be activated by capsaicin and various bacteria.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	88-93
34808551-12	2022	Capsaicin, bacteria and the host mucus system seem to act in a cyclic cascade involving TRPV1, which can be activated by capsaicin and various bacteria.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	88-93
2234408-1	1990	Immunohistochemical and histochemical techniques were used to re-examine the extent to which neonatal capsaicin treatment depletes calcitonin gene-related peptide in the dorsal horn of the spinal cord, to determine the localization of calcitonin gene-related peptide in relation to that of fluoride-resistant acid phosphatase in lumbar dorsal root ganglia, and to compare the distribution of these primary afferent markers in the dorsal horn.	Capsaicin	102-111	acid phosphatase 3	Rattus norvegicus	290-325
34728318-14	2022	Interestingly, the analgesic effect of SZAP was weakened (reduction of PWT and TFL) when TRPV1 and P2X3 were activated by capsaicin or alpha,beta-meATP, respectively.	Capsaicin	122-131	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	89-94
34953209-4	2022	Here, we find that dihydrocapsaicin (DHC), an analogue of capsaicin, is a SG inducer that promotes polysome disassembly and reduces global protein translation via phosphorylation of eIF2alpha.	Capsaicin	58-67	eukaryotic translation initiation factor 2A	Homo sapiens	182-191
34812576-5	2022	Fmr1-KO mice were hyposensitive to mechanical stimuli and intraplantar injections of capsaicin and formalin.	Capsaicin	85-94	fragile X messenger ribonucleoprotein 1	Mus musculus	0-4
34954202-9	2022	Finally, pharmacological experiments using capsaicin to activate pain afferents in the eye demonstrate that Trpm1 expression is required for all sensory driven iris constriction.	Capsaicin	43-52	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	108-113
34465184-8	2021	CRITICAL ISSUES: TRPV1 channels are activated by both capsaicin and cisplatin, which produce differential effects on the inner ear.	Capsaicin	54-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
34465184-10	2021	In contrast, activation of TRPV1 by capsaicin protected against subsequent hearing loss induced by cisplatin.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
34939720-0	2022	Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL-7702 cells.	Capsaicin	0-9	sirtuin 1	Homo sapiens	90-95
34961757-7	2021	Phenotypically, we observed that mice lacking Prdm12 exhibit normal responses to thermal and mechanical nociceptive stimuli but a reduced response to capsaicin and hypersensitivity to formalin-induced inflammatory pain.	Capsaicin	150-159	PR domain containing 12	Mus musculus	46-52
34939720-5	2022	We found that capsaicin increased TOS, 8-OHdG, CASP3, CYC, Bax, and NOX4 levels, and decreased Bcl-2, GSH, and SIRT1 in a concentration-dependent manner in HepG2 cells.	Capsaicin	14-23	caspase 3	Homo sapiens	47-52
34939720-5	2022	We found that capsaicin increased TOS, 8-OHdG, CASP3, CYC, Bax, and NOX4 levels, and decreased Bcl-2, GSH, and SIRT1 in a concentration-dependent manner in HepG2 cells.	Capsaicin	14-23	cytochrome c, somatic	Homo sapiens	54-57
34939720-5	2022	We found that capsaicin increased TOS, 8-OHdG, CASP3, CYC, Bax, and NOX4 levels, and decreased Bcl-2, GSH, and SIRT1 in a concentration-dependent manner in HepG2 cells.	Capsaicin	14-23	BCL2 associated X, apoptosis regulator	Homo sapiens	59-62
34939720-5	2022	We found that capsaicin increased TOS, 8-OHdG, CASP3, CYC, Bax, and NOX4 levels, and decreased Bcl-2, GSH, and SIRT1 in a concentration-dependent manner in HepG2 cells.	Capsaicin	14-23	NADPH oxidase 4	Homo sapiens	68-72
34939720-5	2022	We found that capsaicin increased TOS, 8-OHdG, CASP3, CYC, Bax, and NOX4 levels, and decreased Bcl-2, GSH, and SIRT1 in a concentration-dependent manner in HepG2 cells.	Capsaicin	14-23	BCL2 apoptosis regulator	Homo sapiens	95-100
34939720-5	2022	We found that capsaicin increased TOS, 8-OHdG, CASP3, CYC, Bax, and NOX4 levels, and decreased Bcl-2, GSH, and SIRT1 in a concentration-dependent manner in HepG2 cells.	Capsaicin	14-23	sirtuin 1	Homo sapiens	111-116
34939720-6	2022	However, especially low capsaicin concentration (128.75 microM) enhanced GSH and SIRT levels and reduced TOS, CASP3, CYC, 8-OHdG, and NOX4 levels in HL-7702 cells (p < 0.05).	Capsaicin	24-33	caspase 3	Homo sapiens	110-115
34939720-6	2022	However, especially low capsaicin concentration (128.75 microM) enhanced GSH and SIRT levels and reduced TOS, CASP3, CYC, 8-OHdG, and NOX4 levels in HL-7702 cells (p < 0.05).	Capsaicin	24-33	cytochrome c, somatic	Homo sapiens	117-120
34939720-6	2022	However, especially low capsaicin concentration (128.75 microM) enhanced GSH and SIRT levels and reduced TOS, CASP3, CYC, 8-OHdG, and NOX4 levels in HL-7702 cells (p < 0.05).	Capsaicin	24-33	NADPH oxidase 4	Homo sapiens	134-138
34939720-7	2022	Interestingly, 128.75 and 172.8 microM capsaicin treatment increased SIRT1 expression levels in HL-7702 cells, resulting in an increase in GSH levels and a decrease in TOS, CYC, CAPS3, and 8-OHdG levels through NOX4 inhibition.	Capsaicin	39-48	sirtuin 1	Homo sapiens	69-74
34939720-7	2022	Interestingly, 128.75 and 172.8 microM capsaicin treatment increased SIRT1 expression levels in HL-7702 cells, resulting in an increase in GSH levels and a decrease in TOS, CYC, CAPS3, and 8-OHdG levels through NOX4 inhibition.	Capsaicin	39-48	cytochrome c, somatic	Homo sapiens	173-176
34939720-7	2022	Interestingly, 128.75 and 172.8 microM capsaicin treatment increased SIRT1 expression levels in HL-7702 cells, resulting in an increase in GSH levels and a decrease in TOS, CYC, CAPS3, and 8-OHdG levels through NOX4 inhibition.	Capsaicin	39-48	NADPH oxidase 4	Homo sapiens	211-215
34939720-8	2022	Furthermore, we demonstrated a significant decrease in SIRT1 protein levels and an increase in NOX4 protein levels and caspase-3/-7 activities in both HL-7702 and HepG2 cells treated with 261.5 microM capsaicin.	Capsaicin	201-210	sirtuin 1	Homo sapiens	55-60
34939720-8	2022	Furthermore, we demonstrated a significant decrease in SIRT1 protein levels and an increase in NOX4 protein levels and caspase-3/-7 activities in both HL-7702 and HepG2 cells treated with 261.5 microM capsaicin.	Capsaicin	201-210	NADPH oxidase 4	Homo sapiens	95-99
34939720-8	2022	Furthermore, we demonstrated a significant decrease in SIRT1 protein levels and an increase in NOX4 protein levels and caspase-3/-7 activities in both HL-7702 and HepG2 cells treated with 261.5 microM capsaicin.	Capsaicin	201-210	caspase 3	Homo sapiens	119-131
34939720-10	2022	Our results show that capsaicin effectively might cause higher oxidative, apoptotic, and DNA damage in HepG2 cells than in HL-7702 cells through the SIRT1/NOX4 signaling pathway.	Capsaicin	22-31	sirtuin 1	Homo sapiens	149-154
34939720-10	2022	Our results show that capsaicin effectively might cause higher oxidative, apoptotic, and DNA damage in HepG2 cells than in HL-7702 cells through the SIRT1/NOX4 signaling pathway.	Capsaicin	22-31	NADPH oxidase 4	Homo sapiens	155-159
34950149-8	2021	Furthermore, intraplantar IL-23 only potentiated blue light-induced pain in females, and intrathecal injection of IL-23 also potentiated low-dose capsaicin (500 ng) induced spontaneous pain in females but not males.	Capsaicin	146-155	interleukin 23, alpha subunit p19	Mus musculus	114-119
34171094-2	2021	Capsaicin (Caps), an exogenous agonist of the vanilloid receptor of transient potential type 1 (TRPV1), has shown promising results in the treatment of obesity.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-101
34171094-2	2021	Capsaicin (Caps), an exogenous agonist of the vanilloid receptor of transient potential type 1 (TRPV1), has shown promising results in the treatment of obesity.	Capsaicin	11-15	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-101
34844873-17	2021	More importantly, both capsaicin and dimethyl succinate supplementation obviously counteracted the pain-relieving effect of PF and TRPV1 (P < 0.01 or P < 0.001).	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	131-136
34941893-5	2021	Additionally, high concentrations of capsaicin (0.02-2 mM) damage enterocytes (Caco-2 and HT-29) as indicated by cell viability test, supernatant cytokine (IL-8), transepithelial electrical resistance (TEER) and transepithelial FITC-dextran (4.4 kDa) but were attenuated by Lactobacillus condition media (LCM) from both probiotic-strains.	Capsaicin	37-46	C-X-C motif chemokine ligand 8	Homo sapiens	156-160
34883200-4	2022	CIH yielded enhanced behavioral responses to capsaicin, a TRPV1 agonist, after application to the ocular surface and intraoral mucosa, which was reversed under normoxic conditions.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-63
34798144-7	2021	Finally, we showed that capsaicin inhibited non-canonically induced Smad2/3 activation via suppression of EGFR activation and ERK phosphorylation.	Capsaicin	24-33	SMAD family member 2	Homo sapiens	68-75
34798144-7	2021	Finally, we showed that capsaicin inhibited non-canonically induced Smad2/3 activation via suppression of EGFR activation and ERK phosphorylation.	Capsaicin	24-33	epidermal growth factor receptor	Homo sapiens	106-110
34798144-7	2021	Finally, we showed that capsaicin inhibited non-canonically induced Smad2/3 activation via suppression of EGFR activation and ERK phosphorylation.	Capsaicin	24-33	mitogen-activated protein kinase 1	Homo sapiens	126-129
34939720-0	2022	Capsaicin inhibits cell proliferation by enhancing oxidative stress and apoptosis through SIRT1/NOX4 signaling pathways in HepG2 and HL-7702 cells.	Capsaicin	0-9	NADPH oxidase 4	Homo sapiens	96-100
34939720-2	2022	This study investigates the effects of capsaicin in both hepatocellular carcinoma (HepG2) and normal hepatocytes (HL-7702) via the SIRT1/NOX4 signaling pathway.	Capsaicin	39-48	sirtuin 1	Homo sapiens	131-136
34939720-2	2022	This study investigates the effects of capsaicin in both hepatocellular carcinoma (HepG2) and normal hepatocytes (HL-7702) via the SIRT1/NOX4 signaling pathway.	Capsaicin	39-48	NADPH oxidase 4	Homo sapiens	137-141
34899333-5	2021	Low pH (pH 6) activates TRPV1, a polymodal ion channel also activated by heat, capsaicin and hyperosmolar conditions.	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
34884463-7	2021	Capsaicin caused an increase in TRPV4 membrane localization, but had no effect on TRPV1; while GSK101 decreased the membrane localization of TRPV4 and increased the membrane localization of TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	32-37
34884463-7	2021	Capsaicin caused an increase in TRPV4 membrane localization, but had no effect on TRPV1; while GSK101 decreased the membrane localization of TRPV4 and increased the membrane localization of TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	141-146
34884463-7	2021	Capsaicin caused an increase in TRPV4 membrane localization, but had no effect on TRPV1; while GSK101 decreased the membrane localization of TRPV4 and increased the membrane localization of TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	190-195
34600694-10	2021	Thickness discrimination thresholds (i.e., BET expressed as Deltaeta50s-1) increased significantly from 11.3 mPas at 0 ppm to 16.1 mPas at 1 ppm (42% increase) to 21.4 mPas at 10 ppm capsaicin (89% increase) on average across all participants.	Capsaicin	183-192	delta/notch like EGF repeat containing	Homo sapiens	43-46
34165751-10	2021	Cold and low-dose capsaicin exposure groups were also increased TLR2 and TLR4 protein levels and mRNA levels.	Capsaicin	18-27	toll-like receptor 2	Rattus norvegicus	64-68
34165751-10	2021	Cold and low-dose capsaicin exposure groups were also increased TLR2 and TLR4 protein levels and mRNA levels.	Capsaicin	18-27	toll-like receptor 4	Rattus norvegicus	73-77
34600695-5	2021	Chia oil mechanism of action was investigated using nociception and paw edema response induced by intraplantar injection of acidified saline (ASIC activator), PGE2 (prostaglandin pathway), cinnamaldehyde (TRPA1 activator), bradykinin (BK pathway), menthol (TRPM8 activator), and capsaicin (TRPV1 activator).	Capsaicin	279-288	chitinase acidic	Homo sapiens	0-4
34724681-1	2021	ABSTRACT: Capsaicin is a specific agonist of transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptors.	Capsaicin	10-19	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-85
34724681-1	2021	ABSTRACT: Capsaicin is a specific agonist of transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptors.	Capsaicin	10-19	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	87-92
34724681-3	2021	Although capsaicin-induced TRPV1 and Ca2+/calpain-dependent ablation of axonal terminals is necessary for long-lasting analgesia, the mechanisms underlying capsaicin-induced ablation of axonal terminals and its association with analgesia are not fully understood.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
34724681-13	2021	Further understanding of TRPV1/Ca2+-dependent mechanisms of capsaicin-induced ablation and analgesia may help to improve the management of chronic pain.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-30
34672430-8	2022	CONCLUSIONS: The present study demonstrated for the first time, that SPE inhibited capsaicin-induced Ca2+ influx with binding to TRPV1 in HEL293VR11 cells.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	129-134
34754156-9	2021	Additionally, abnormal accumulation of both collagen and elastin was observed in the cold exposure and capsaicin group.	Capsaicin	103-112	elastin	Rattus norvegicus	57-64
34754156-12	2021	Cold exposure and capsaicin significantly increased the protein levels of COL I, elastin, and LOXL2 along with increases in their mRNA levels in the colon tissues compared with the DMH group, while COL III did not show a significant difference.	Capsaicin	18-27	elastin	Rattus norvegicus	81-88
34754156-12	2021	Cold exposure and capsaicin significantly increased the protein levels of COL I, elastin, and LOXL2 along with increases in their mRNA levels in the colon tissues compared with the DMH group, while COL III did not show a significant difference.	Capsaicin	18-27	lysyl oxidase-like 2	Rattus norvegicus	94-99
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	Capsaicin	121-130	matrix metallopeptidase 1	Rattus norvegicus	49-53
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	Capsaicin	121-130	matrix metallopeptidase 2	Rattus norvegicus	55-59
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	Capsaicin	121-130	matrix metallopeptidase 9	Rattus norvegicus	61-65
34754156-13	2021	Furthermore, in immunohistochemical evaluations, MMP1, MMP2, MMP9, and TIMP1 staining increased in the cold exposure and capsaicin group compared with the DMH group.	Capsaicin	121-130	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	71-76
34754156-14	2021	CONCLUSION: These results suggest that chronic cold and capsaicin exposure further increased the deposition of collagen and elastin in the colonic tissue.	Capsaicin	56-65	elastin	Rattus norvegicus	124-131
34754156-16	2021	The upregulated expression of the LOXL2 and physiological imbalance between MMP/TIMP activation and deactivation could contribute to the progression of the CRC resulting from cold and capsaicin exposure.	Capsaicin	184-193	lysyl oxidase-like 2	Rattus norvegicus	34-39
34754156-16	2021	The upregulated expression of the LOXL2 and physiological imbalance between MMP/TIMP activation and deactivation could contribute to the progression of the CRC resulting from cold and capsaicin exposure.	Capsaicin	184-193	matrix metallopeptidase 1	Rattus norvegicus	76-79
34754156-16	2021	The upregulated expression of the LOXL2 and physiological imbalance between MMP/TIMP activation and deactivation could contribute to the progression of the CRC resulting from cold and capsaicin exposure.	Capsaicin	184-193	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	80-84
34657531-4	2021	In this review, the modulating effects of capsaicin on glucose homeostasis in cell models, animal models and human trials are summarized through both TRPV1 dependent and TRPV1 independent pathways.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	150-155
34657531-4	2021	In this review, the modulating effects of capsaicin on glucose homeostasis in cell models, animal models and human trials are summarized through both TRPV1 dependent and TRPV1 independent pathways.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	170-175
34703269-0	2021	Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-kappaB and PI3K/AKT/mTOR Pathways.	Capsaicin	0-9	high mobility group box 1	Mus musculus	84-89
34703269-0	2021	Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-kappaB and PI3K/AKT/mTOR Pathways.	Capsaicin	0-9	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	90-99
34703269-0	2021	Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-kappaB and PI3K/AKT/mTOR Pathways.	Capsaicin	0-9	thymoma viral proto-oncogene 1	Mus musculus	109-112
34703269-0	2021	Capsaicin Protects Against Lipopolysaccharide-Induced Acute Lung Injury Through the HMGB1/NF-kappaB and PI3K/AKT/mTOR Pathways.	Capsaicin	0-9	mechanistic target of rapamycin kinase	Mus musculus	113-117
34691215-6	2021	Osthole and the TRPV1 agonist capsaicin-induced calcium influx were desensitized by pretreatment with osthole.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	16-21
34470979-2	2021	We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through alpha2 receptors in cultured rat dorsal root ganglion (DRG) neurons.	Capsaicin	115-124	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-96
34692753-0	2021	TRPV1 Receptor-Mediated Hypoglycemic Mechanism of Capsaicin in Streptozotocin-Induced Diabetic Rats.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
34692753-1	2021	Our previous research showed that capsaicin exhibits hypoglycemic effects by activating the transient receptor potential vanilloid 1 (TRPV1) channel in diabetic rats.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	92-132
34692753-1	2021	Our previous research showed that capsaicin exhibits hypoglycemic effects by activating the transient receptor potential vanilloid 1 (TRPV1) channel in diabetic rats.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-139
34692753-3	2021	This study aimed to investigate the effect of capsaicin on the glycometabolism of streptozotocin (STZ)-induced diabetic rats by blocking the TRPV1 channel.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	141-146
34692753-6	2021	It was concluded that a combined up-regulation of both TRPV1 receptors and pancreatic duodenal homeobox-1 (PDX-1) led to the hypoglycemic effect of capsaicin, which partially explains our previous observation: capsiate activating TRPV1 without showing a significant hypoglycemic effect was due to the lack of a significant up-regulation of PDX-1.	Capsaicin	148-157	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-60
34692753-6	2021	It was concluded that a combined up-regulation of both TRPV1 receptors and pancreatic duodenal homeobox-1 (PDX-1) led to the hypoglycemic effect of capsaicin, which partially explains our previous observation: capsiate activating TRPV1 without showing a significant hypoglycemic effect was due to the lack of a significant up-regulation of PDX-1.	Capsaicin	148-157	pancreatic and duodenal homeobox 1	Rattus norvegicus	75-105
34692753-6	2021	It was concluded that a combined up-regulation of both TRPV1 receptors and pancreatic duodenal homeobox-1 (PDX-1) led to the hypoglycemic effect of capsaicin, which partially explains our previous observation: capsiate activating TRPV1 without showing a significant hypoglycemic effect was due to the lack of a significant up-regulation of PDX-1.	Capsaicin	148-157	pancreatic and duodenal homeobox 1	Rattus norvegicus	107-112
34692753-6	2021	It was concluded that a combined up-regulation of both TRPV1 receptors and pancreatic duodenal homeobox-1 (PDX-1) led to the hypoglycemic effect of capsaicin, which partially explains our previous observation: capsiate activating TRPV1 without showing a significant hypoglycemic effect was due to the lack of a significant up-regulation of PDX-1.	Capsaicin	148-157	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	230-235
34470979-2	2021	We reported that noradrenaline inhibits the activity of transient receptor potential vanilloid 1 (TRPV1) evoked by capsaicin through alpha2 receptors in cultured rat dorsal root ganglion (DRG) neurons.	Capsaicin	115-124	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
34364049-1	2021	Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high permeability to Ca2+, which can be activated by low pH, noxious heat and vanilloid compounds such as capsaicin.	Capsaicin	194-203	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
34364049-1	2021	Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high permeability to Ca2+, which can be activated by low pH, noxious heat and vanilloid compounds such as capsaicin.	Capsaicin	194-203	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	Capsaicin	271-280	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	46-51
34481181-8	2021	MATERIALS AND METHODS: A hypothetical mutated spike protein was constructed by incorporating twelve different mutations from twelve geographical locations simultaneously into the receptor-binding domain (RBD) and docked with ACE2 and seven phytochemicals namely allicin, capsaicin, cinnamaldehyde, curcumin, gingerol, piperine and zingeberene.	Capsaicin	271-280	angiotensin converting enzyme 2	Homo sapiens	225-229
34331901-8	2021	Hypothermia also promoted a reduction in mRNA expression of the capsaicin receptor TRPV1 in H9c2 cells.	Capsaicin	64-73	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
34659883-0	2021	Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	50-54
34241806-3	2021	TRPV1 is activated by capsaicin and reactive free oxygen radicals (fROS) to mediate peripheral neuropathy and neurotoxicity.	Capsaicin	22-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
34630139-4	2021	The results showed that the pre-treatment of cells with capsaicin (100 muM) significantly decreased the gene expression and secretion of proinflammatory cytokines induced by LPS through Toll-like receptor 4 (TLR4)/NF-kappaB signaling pathway.	Capsaicin	56-65	toll like receptor 4	Sus scrofa	186-206
34630139-4	2021	The results showed that the pre-treatment of cells with capsaicin (100 muM) significantly decreased the gene expression and secretion of proinflammatory cytokines induced by LPS through Toll-like receptor 4 (TLR4)/NF-kappaB signaling pathway.	Capsaicin	56-65	toll like receptor 4	Sus scrofa	208-212
34630139-7	2021	Additionally, pre-treatment of cells with capsaicin upregulated the mRNA abundance of nutrients transporters such as Na+/glucose cotransporter 1 (SGLT1).	Capsaicin	42-51	solute carrier family 5 member 1	Sus scrofa	117-144
34630139-7	2021	Additionally, pre-treatment of cells with capsaicin upregulated the mRNA abundance of nutrients transporters such as Na+/glucose cotransporter 1 (SGLT1).	Capsaicin	42-51	solute carrier family 5 member 1	Sus scrofa	146-151
34630139-8	2021	These results suggested that capsaicin could attenuate LPS-induced inflammation response through TLR4/NF-kappaB pathway and improve barrier integrity and glucose absorption.	Capsaicin	29-38	toll like receptor 4	Sus scrofa	97-101
34533076-3	2021	Transient Receptor Potential Vanilloid 1 (TRPV1) is an ion channel involving in the cytotoxicity of capsaicin.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
34533076-3	2021	Transient Receptor Potential Vanilloid 1 (TRPV1) is an ion channel involving in the cytotoxicity of capsaicin.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
34659883-7	2021	The essential role of tNOX in tumor- and melanoma-growth limiting abilities of capsaicin was evaluated in C57BL/6 mice.	Capsaicin	79-88	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	22-26
34659883-8	2021	Our data show that capsaicin directly engaged with cellular tNOX to inhibit its enzymatic activity and enhance protein degradation capacity.	Capsaicin	19-28	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	60-64
34659883-9	2021	The inhibition of tNOX by capsaicin was accompanied by the attenuation of SIRT1, a NAD+-dependent deacetylase.	Capsaicin	26-35	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	18-22
34659883-0	2021	Capsaicin exerts therapeutic effects by targeting tNOX-SIRT1 axis and augmenting ROS-dependent autophagy in melanoma cancer cells.	Capsaicin	0-9	sirtuin 1	Mus musculus	55-60
34659883-9	2021	The inhibition of tNOX by capsaicin was accompanied by the attenuation of SIRT1, a NAD+-dependent deacetylase.	Capsaicin	26-35	sirtuin 1	Mus musculus	74-79
34659883-11	2021	Capsaicin treatment of mice implanted with melanoma cancer cells suppressed tumor growth by down-regulating tNOX and SIRT1, which was also seen in an in vivo xenograft study with tNOX-depleted melanoma cells.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	108-112
34659883-11	2021	Capsaicin treatment of mice implanted with melanoma cancer cells suppressed tumor growth by down-regulating tNOX and SIRT1, which was also seen in an in vivo xenograft study with tNOX-depleted melanoma cells.	Capsaicin	0-9	sirtuin 1	Mus musculus	117-122
34659883-5	2021	The cellular thermal shift assay (CETSA), isothermal dose-response fingerprint curves (ITDRFCETSA), and CETSA-pulse proteolysis were utilized to confirm the direct binding of capsaicin with the tumor-associated NADH oxidase, tNOX (ENOX2) in melanoma cells.	Capsaicin	175-184	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	225-229
34659883-5	2021	The cellular thermal shift assay (CETSA), isothermal dose-response fingerprint curves (ITDRFCETSA), and CETSA-pulse proteolysis were utilized to confirm the direct binding of capsaicin with the tumor-associated NADH oxidase, tNOX (ENOX2) in melanoma cells.	Capsaicin	175-184	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	231-236
34659883-6	2021	We also assessed the cellular impact of capsaicin-targeting of tNOX on A375 cells by flow cytometry and protein analysis.	Capsaicin	40-49	ecto-NOX disulfide-thiol exchanger 2	Mus musculus	63-67
34504955-1	2021	Both a silent resident phosphatidylinositol lipid and a "hot" vanilloid agonist capsaicin or resiniferatoxin have been shown to share the same inter-subunit binding pocket between a voltage sensor like domain and a pore domain in TRPV1.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	230-235
34353899-3	2021	Here, we demonstrate that functional CaV2.2 channels in peripheral axons innervating skin are required for capsaicin-induced heat hypersensitivity in male and female mice.	Capsaicin	107-116	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	37-43
34273488-3	2021	Among the compounds, antagonists 28 and 92 exhibited potent antagonism toward capsaicin for hTRPV1 with Ki(CAP) = 2.6 and 6.9 nM, respectively.	Capsaicin	78-87	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-98
34198164-5	2021	Myogenesis was effectively enhanced in C2C12 cells treated with a combination of capsaicin (300 muM) for one day before differentiation stimulation and AsAp for four days post-differentiation; subsequently, thick and long myotubes formed, and the expression levels of myosin heavy chain (MYH) 1/2 and Myh1, Myh4, and Myh7 increased.	Capsaicin	81-90	myosin, heavy polypeptide 1, skeletal muscle, adult	Mus musculus	268-296
34198164-5	2021	Myogenesis was effectively enhanced in C2C12 cells treated with a combination of capsaicin (300 muM) for one day before differentiation stimulation and AsAp for four days post-differentiation; subsequently, thick and long myotubes formed, and the expression levels of myosin heavy chain (MYH) 1/2 and Myh1, Myh4, and Myh7 increased.	Capsaicin	81-90	myosin, heavy polypeptide 1, skeletal muscle, adult	Mus musculus	301-305
34198164-5	2021	Myogenesis was effectively enhanced in C2C12 cells treated with a combination of capsaicin (300 muM) for one day before differentiation stimulation and AsAp for four days post-differentiation; subsequently, thick and long myotubes formed, and the expression levels of myosin heavy chain (MYH) 1/2 and Myh1, Myh4, and Myh7 increased.	Capsaicin	81-90	myosin, heavy polypeptide 4, skeletal muscle	Mus musculus	307-311
34198164-5	2021	Myogenesis was effectively enhanced in C2C12 cells treated with a combination of capsaicin (300 muM) for one day before differentiation stimulation and AsAp for four days post-differentiation; subsequently, thick and long myotubes formed, and the expression levels of myosin heavy chain (MYH) 1/2 and Myh1, Myh4, and Myh7 increased.	Capsaicin	81-90	myosin, heavy polypeptide 7, cardiac muscle, beta	Mus musculus	317-321
34198164-6	2021	Considering that mild ER stress stimulates myogenesis, AsAp may elicit myogenesis through the alleviation of oxidative stress-induced negative effects in capsaicin-pretreated cells.	Capsaicin	154-163	anti-sarcolemmal autoantibodies	Mus musculus	55-59
34302514-9	2021	8% capsaicin ablation predominantly defunctionalizes TRPV1+-expressing cutaneous nociceptors responsible for heat pain transduction, suggesting that sensitization of these fibers is required for development of heat hyperalgesia following cutaneous UVB-induced inflammation but they are likely only partially necessary for the establishment of robust primary mechanical hyperalgesia.	Capsaicin	3-12	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-58
34353899-4	2021	We show that CaV2.2 channels in TRPV1-nociceptor endings are activated by capsaicin-induced depolarization and contribute to increased intracellular calcium.	Capsaicin	74-83	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	13-19
34353899-4	2021	We show that CaV2.2 channels in TRPV1-nociceptor endings are activated by capsaicin-induced depolarization and contribute to increased intracellular calcium.	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
34353899-5	2021	Capsaicin induces hypersensitivity of both thermal nociceptors and mechanoreceptors, but only heat hypersensitivity depends on peripheral CaV2.2 channel activity, and especially a cell type-specific CaV2.2 splice isoform.	Capsaicin	0-9	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	199-205
34353899-7	2021	We show that peripheral CaV2.2 channels are essential for the classic, heat hypersensitivity response to develop in skin following capsaicin exposure.	Capsaicin	131-140	calcium channel, voltage-dependent, N type, alpha 1B subunit	Mus musculus	24-30
34328106-9	2021	The results showed that capsaicin administration obstructed the activation of IL-23/IL-17 pathway induced by imiquimod, presenting with significantly reduced psoriasiform dermatitis both in gross appearance and microscopic features.	Capsaicin	24-33	interleukin 23, alpha subunit p19	Mus musculus	78-83
34328106-9	2021	The results showed that capsaicin administration obstructed the activation of IL-23/IL-17 pathway induced by imiquimod, presenting with significantly reduced psoriasiform dermatitis both in gross appearance and microscopic features.	Capsaicin	24-33	interleukin 17A	Mus musculus	84-89
34328106-10	2021	Tissue gene expression of psoriatic core cytokines induced by imiquimod (including IL-23, IL-17A, IL-22, TNF-alpha, and IL-6) were greatly decreased by capsaicin application.	Capsaicin	152-161	interleukin 23, alpha subunit p19	Mus musculus	83-88
34328106-10	2021	Tissue gene expression of psoriatic core cytokines induced by imiquimod (including IL-23, IL-17A, IL-22, TNF-alpha, and IL-6) were greatly decreased by capsaicin application.	Capsaicin	152-161	interleukin 17A	Mus musculus	90-96
34328106-10	2021	Tissue gene expression of psoriatic core cytokines induced by imiquimod (including IL-23, IL-17A, IL-22, TNF-alpha, and IL-6) were greatly decreased by capsaicin application.	Capsaicin	152-161	interleukin 22	Mus musculus	98-103
34328106-10	2021	Tissue gene expression of psoriatic core cytokines induced by imiquimod (including IL-23, IL-17A, IL-22, TNF-alpha, and IL-6) were greatly decreased by capsaicin application.	Capsaicin	152-161	tumor necrosis factor	Mus musculus	105-114
34328106-10	2021	Tissue gene expression of psoriatic core cytokines induced by imiquimod (including IL-23, IL-17A, IL-22, TNF-alpha, and IL-6) were greatly decreased by capsaicin application.	Capsaicin	152-161	interleukin 6	Mus musculus	120-124
34328106-11	2021	This protective effect from capsaicin could be hampered by direct intradermal injection of IL-23.	Capsaicin	28-37	interleukin 23, alpha subunit p19	Mus musculus	91-96
34512323-7	2021	In co-treated cells, the induction of apoptosis was significantly reduced and the levels of the necroptosis markers, phospho-MLKL and phospho-RIP3, were increased relative to the levels seen in capsaicin treatment alone.	Capsaicin	194-203	mixed lineage kinase domain like pseudokinase	Homo sapiens	125-129
34332978-1	2021	Transient Receptor Potential vanilloid 1 (TRPV1) ion channel serves as the detector for noxious temperature above 42 C, pungent chemicals like capsaicin and acidic extracellular pH.	Capsaicin	143-152	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
34332978-1	2021	Transient Receptor Potential vanilloid 1 (TRPV1) ion channel serves as the detector for noxious temperature above 42 C, pungent chemicals like capsaicin and acidic extracellular pH.	Capsaicin	143-152	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
34332978-5	2021	We found that these endocannabinoid ligands bind to the vanilloid binding pocket of TRPV1 in the "tail-up, head-down" configuration, similar to capsaicin; however, there is a unique interaction with TRPV1 Y512 residue critical for endocannabinoid activation of TRPV1 channels.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	84-89
34332978-5	2021	We found that these endocannabinoid ligands bind to the vanilloid binding pocket of TRPV1 in the "tail-up, head-down" configuration, similar to capsaicin; however, there is a unique interaction with TRPV1 Y512 residue critical for endocannabinoid activation of TRPV1 channels.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
34332978-6	2021	These data suggest a differential structural mechanism is involved in TRPV1 activation by endocannabinoids compared to the classic agonist capsaicin.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
34127538-7	2021	Multiparametric analysis of our results shed light on the capability of calmodulin inhibitors included in the Prestwick library to inhibit TRPV1 activation by Capsaicin (CAPS).	Capsaicin	159-168	calmodulin 1	Homo sapiens	72-82
34127538-7	2021	Multiparametric analysis of our results shed light on the capability of calmodulin inhibitors included in the Prestwick library to inhibit TRPV1 activation by Capsaicin (CAPS).	Capsaicin	159-168	transient receptor potential cation channel subfamily V member 1	Homo sapiens	139-144
34127538-7	2021	Multiparametric analysis of our results shed light on the capability of calmodulin inhibitors included in the Prestwick library to inhibit TRPV1 activation by Capsaicin (CAPS).	Capsaicin	170-174	calmodulin 1	Homo sapiens	72-82
34127538-7	2021	Multiparametric analysis of our results shed light on the capability of calmodulin inhibitors included in the Prestwick library to inhibit TRPV1 activation by Capsaicin (CAPS).	Capsaicin	170-174	transient receptor potential cation channel subfamily V member 1	Homo sapiens	139-144
34512323-7	2021	In co-treated cells, the induction of apoptosis was significantly reduced and the levels of the necroptosis markers, phospho-MLKL and phospho-RIP3, were increased relative to the levels seen in capsaicin treatment alone.	Capsaicin	194-203	myosin phosphatase Rho interacting protein	Homo sapiens	142-146
34446102-5	2021	In addition, we found significantly increased capsaicin induced Ca2+ response, TRPV1 currents and neuronal firing in AnxA1 deficient DRG neurons.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	79-84
34446102-5	2021	In addition, we found significantly increased capsaicin induced Ca2+ response, TRPV1 currents and neuronal firing in AnxA1 deficient DRG neurons.	Capsaicin	46-55	annexin A1	Mus musculus	117-122
34446102-8	2021	CONCLUSIONS: Selective deletion of AnxA1 in DRG neurons enhances TRPV1 sensitivity and deteriorates noxious heat or capsaicin induced nociception, while ANXA1 mimic peptide Ac2-26 desensitizes TRPV1 via FPR2 and the downstream PLCbeta-Ca2+-CaM signal.	Capsaicin	116-125	annexin A1	Mus musculus	35-40
34445392-6	2021	We found that while capsaicin inhibits oral cancer cell proliferation and metabolism (MT Glo assay) and increases cell death (Trypan blue exclusion assay and Caspase 3/7 expression), its anti-cancer effect was significantly reduced on cells that are either primed or exposed to the bacterial antigens.	Capsaicin	20-29	caspase 3	Homo sapiens	158-169
34421629-7	2021	However, sinomenine, a component of traditional Chinese medicine, significantly attenuated the capsaicin-induced cough by inhibiting the expression of TRPV1 in guinea pigs.	Capsaicin	95-104	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	151-156
34421629-0	2021	Sinomenine Attenuated Capsaicin-Induced Increase in Cough Sensitivity in Guinea Pigs by Inhibiting SOX5/TRPV1 Axis and Inflammatory Response.	Capsaicin	22-31	transcription factor SOX-5	Cavia porcellus	99-103
34445178-6	2021	TRPV1 became immobile after capsaicin stimulation, followed by its gradual endocytosis.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
34421629-8	2021	In addition, capsaicin increased the expression of SOX5 which mediated the transcriptional upregulation of TRPV1.	Capsaicin	13-22	transcription factor SOX-5	Cavia porcellus	51-55
34421629-0	2021	Sinomenine Attenuated Capsaicin-Induced Increase in Cough Sensitivity in Guinea Pigs by Inhibiting SOX5/TRPV1 Axis and Inflammatory Response.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	104-109
34421629-6	2021	Results: Capsaicin induced increase in cough sensitivity by upregulating the protein level of TRPV1, leading to the secretions of Substance P and neurokinin A which stimulated neurogenic inflammation.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-99
34421629-8	2021	In addition, capsaicin increased the expression of SOX5 which mediated the transcriptional upregulation of TRPV1.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	107-112
34421629-10	2021	Conclusion: These results indicate that capsaicin induced increase in cough sensitivity by activating neurogenic inflammation, while sinomenine attenuated the increase in cough sensitivity by inhibiting the expressions of SOX5 and TRPV1 in guinea pigs.	Capsaicin	40-49	transcription factor SOX-5	Cavia porcellus	222-226
34421629-10	2021	Conclusion: These results indicate that capsaicin induced increase in cough sensitivity by activating neurogenic inflammation, while sinomenine attenuated the increase in cough sensitivity by inhibiting the expressions of SOX5 and TRPV1 in guinea pigs.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	231-236
34304690-12	2021	Additionally, capsaicin potently prevented the ouabain-induced decrease in GSK-3beta phosphorylation.	Capsaicin	14-23	glycogen synthase kinase 3 alpha	Homo sapiens	75-84
34438718-1	2021	Cinnamaldehyde and capsaicin have been reported to exert effects on the gastric function, mediated by the interaction with transient receptor potential ankyrin channel 1 (TRPA1) and transient receptor potential vanilloid channel 1 (TRPV1), respectively.	Capsaicin	19-28	transient receptor potential cation channel subfamily A member 1	Sus scrofa	123-169
34438718-1	2021	Cinnamaldehyde and capsaicin have been reported to exert effects on the gastric function, mediated by the interaction with transient receptor potential ankyrin channel 1 (TRPA1) and transient receptor potential vanilloid channel 1 (TRPV1), respectively.	Capsaicin	19-28	transient receptor potential cation channel subfamily A member 1	Sus scrofa	171-176
34438718-1	2021	Cinnamaldehyde and capsaicin have been reported to exert effects on the gastric function, mediated by the interaction with transient receptor potential ankyrin channel 1 (TRPA1) and transient receptor potential vanilloid channel 1 (TRPV1), respectively.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Sus scrofa	182-230
34438718-1	2021	Cinnamaldehyde and capsaicin have been reported to exert effects on the gastric function, mediated by the interaction with transient receptor potential ankyrin channel 1 (TRPA1) and transient receptor potential vanilloid channel 1 (TRPV1), respectively.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Sus scrofa	232-237
34304690-13	2021	In contrast, capsazepine potentiated ouabain-induced decrease in GSK-3beta phosphorylation and combination with capsaicin, suppressed the effect of capsazepine on GSK-3beta phosphorylation.	Capsaicin	112-121	glycogen synthase kinase 3 alpha	Homo sapiens	163-172
34442487-9	2021	However, in printed neurons, we found compromised neurite outgrowth and lower sensitivity to the ligand of the TRPV1 channel, capsaicin.	Capsaicin	126-135	transient receptor potential cation channel subfamily V member 1	Homo sapiens	111-116
34249519-1	2021	Background: The calcitonin gene-related peptide (CGRP) is a neuropeptide that is released from capsaicin-sensitive nerves as a potent vasodilator involved in nociceptive transmission.	Capsaicin	95-104	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	16-47
34356536-7	2021	Based on the lowest-scoring values, ZINC08441573, ZINC00664754, ZINC00702695, ZINC00627464, and ZINC08440501 (synthetic compounds), and capsaicin, flavopiridol tectorgenin, and ellagic acid (natural compounds) showed incredible interactions with the active sites of ERalpha, even more convening and resilient than standard breast cancer drugs Tamoxifen, Arimidex and Letrozole.	Capsaicin	136-145	estrogen receptor 1	Homo sapiens	266-273
34282193-4	2021	Human induced pluripotent stem cell (iPSC)-derived cardiomyocytes (hiPSC-CM) from 4 healthy donors were incubated with lipopolysaccharides (LPS, 6 h), TRPV1 agonist capsaicin (CAP, 20 min) or the antagonist capsazepine (CPZ, 20 min).	Capsaicin	165-174	transient receptor potential cation channel subfamily V member 1	Homo sapiens	151-156
34242501-1	2021	BACKGROUND/AIMS: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying CAPS concentration (CAPS) remain obscure.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	69-109
34242501-1	2021	BACKGROUND/AIMS: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying CAPS concentration (CAPS) remain obscure.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	111-116
34242501-1	2021	BACKGROUND/AIMS: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying CAPS concentration (CAPS) remain obscure.	Capsaicin	55-59	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	69-109
34242501-1	2021	BACKGROUND/AIMS: Nociceptors detect noxious capsaicin (CAPS) via the transient receptor potential vanilloid 1 (TRPV1) ion channel, but coding mechanisms for relaying CAPS concentration (CAPS) remain obscure.	Capsaicin	55-59	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	111-116
34235954-9	2021	Overall, capsaicin reduced the secretion of inflammatory cytokines (P<0.01), interleukins, TNF-alpha (P<0.01), and NO by inhibiting the nuclear factor-kappa B and microtubule-associated protein kinase signaling pathways, and thereby reduced lipopolysaccharide-induced inflammatory response in macrophages.	Capsaicin	9-18	tumor necrosis factor	Mus musculus	91-100
34249519-1	2021	Background: The calcitonin gene-related peptide (CGRP) is a neuropeptide that is released from capsaicin-sensitive nerves as a potent vasodilator involved in nociceptive transmission.	Capsaicin	95-104	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	49-53
34239124-4	2021	The heat-induced transformations of TRPV3 are accompanied by changes in the secondary structure of the S2-S3 linker and the N and C termini and represent a conformational wave that links these parts of the protein to a lipid occupying the vanilloid binding site.	Capsaicin	239-248	transient receptor potential cation channel, subfamily V, member 3	Mus musculus	36-41
34289785-12	2021	In addition to the analgesic effect, TRPV1 agonist-Capsaicin possesses a disease-modifying effect in CIPN through its restorative property in damaged sensory nerves.	Capsaicin	51-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
35405615-0	2022	Capsaicin ameliorates intermittent high glucose-mediated endothelial senescence via the TRPV1/SIRT1 pathway.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
34248678-2	2021	Experiments were undertaken to examine the mechanisms underlying effects of TRPA1 (allyl isothiocyanate, AITC), TRPV1 (capsaicin, CAPS), and TRPC (oleoyl-2-acetyl-sn-glycerol, OAG) agonists on guinea pig bladder activity.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	112-117
34205555-0	2021	TRPV1 Activation by Capsaicin Mediates Glucose Oxidation and ATP Production Independent of Insulin Signalling in Mouse Skeletal Muscle Cells.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
34205555-2	2021	Emerging research has highlighted transient receptor potential cation channel subfamily V member (TRPV1) activation by capsaicin as a potential therapeutic target for these conditions.	Capsaicin	119-128	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	98-103
34205555-7	2021	RESULTS: Capsaicin activated cell signalling molecules including CAMKK2 and AMPK leading to increased glucose oxidation and ATP generation independent of insulin in the differentiated C2C12 cells.	Capsaicin	9-18	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	65-71
34205555-9	2021	Moreover, we observed an inhibitory effect of capsaicin in the phosphorylation of ERK1/2 in the mouse myotubes.	Capsaicin	46-55	mitogen-activated protein kinase 3	Mus musculus	82-88
34205555-10	2021	CONCLUSION: Our data show that capsaicin-mediated stimulation of TRPV1 in differentiated C2C12 cells leads to activation of CAMKK2 and AMPK, and increased glucose oxidation which is concomitant with an elevation in intracellular ATP level.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
34205555-10	2021	CONCLUSION: Our data show that capsaicin-mediated stimulation of TRPV1 in differentiated C2C12 cells leads to activation of CAMKK2 and AMPK, and increased glucose oxidation which is concomitant with an elevation in intracellular ATP level.	Capsaicin	31-40	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	124-130
34205555-11	2021	Further studies of the effect of TRPV1 channel activation by capsaicin on glucose metabolism could provide novel therapeutic utility for the management of IR and T2DM.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	33-38
34200268-6	2021	Nanocrystals loaded with capsaicin showed particle size 120 +- 3.0 nm with surface charge of -20.7 +- 3.5 and PDI was 0.48 +- 1.5.	Capsaicin	25-34	prolyl 4-hydroxylase subunit beta	Rattus norvegicus	110-113
34113239-1	2021	Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor (TRPV1) in capsaicin-induced acute inflammatory pain and the possible mechanism of action.	Capsaicin	266-275	solute carrier family 12 member 2	Rattus norvegicus	144-149
34113239-1	2021	Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor (TRPV1) in capsaicin-induced acute inflammatory pain and the possible mechanism of action.	Capsaicin	266-275	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	205-254
34113239-1	2021	Background Our aim was to investigate the effects of the protein expression and the function of sodium, potassium, and chloride co-transporter (NKCC1) in the dorsal root ganglion (DRG) after activation of transient receptor potential vanilloid 1 receptor (TRPV1) in capsaicin-induced acute inflammatory pain and the possible mechanism of action.	Capsaicin	266-275	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	256-261
34113239-9	2021	Compared with the control group, the immunofluorescence intensity of NKCC1 and p-NKCC1 in the capsaicin group was significantly higher, and the expression of NKCC1 in the nuclear membrane was significantly higher than that in the control group.	Capsaicin	94-103	solute carrier family 12 member 2	Rattus norvegicus	69-74
34113239-9	2021	Compared with the control group, the immunofluorescence intensity of NKCC1 and p-NKCC1 in the capsaicin group was significantly higher, and the expression of NKCC1 in the nuclear membrane was significantly higher than that in the control group.	Capsaicin	94-103	solute carrier family 12 member 2	Rattus norvegicus	81-86
34113239-10	2021	The expression of NKCC1 mRNA and protein of NKCC1 and p-NKCC1 in the capsaicin group were higher than those in the control group.	Capsaicin	69-78	solute carrier family 12 member 2	Rattus norvegicus	18-23
34113239-10	2021	The expression of NKCC1 mRNA and protein of NKCC1 and p-NKCC1 in the capsaicin group were higher than those in the control group.	Capsaicin	69-78	solute carrier family 12 member 2	Rattus norvegicus	44-49
34113239-10	2021	The expression of NKCC1 mRNA and protein of NKCC1 and p-NKCC1 in the capsaicin group were higher than those in the control group.	Capsaicin	69-78	solute carrier family 12 member 2	Rattus norvegicus	56-61
34113239-11	2021	After capsaicin injection, GF109203X inhibited the protein expression of NKCC1 and p-ERK, while U0126 inhibited the protein expression of NKCC1.	Capsaicin	6-15	solute carrier family 12 member 2	Rattus norvegicus	73-78
34113239-11	2021	After capsaicin injection, GF109203X inhibited the protein expression of NKCC1 and p-ERK, while U0126 inhibited the protein expression of NKCC1.	Capsaicin	6-15	Eph receptor B1	Rattus norvegicus	85-88
34093200-2	2021	TRPV1 is activated by capsaicin, thermal stimuli higher than 43 C, mechanical stress, and protons (H+).	Capsaicin	22-31	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
34093200-4	2021	In the presence of capsaicin, voltage-dependent probability of opening of the TRPV1 channel and its kinetics have been examined, but the characteristics in the low pH remain unclear.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
34093200-5	2021	To understand the voltage-dependency of the TRPV1 channel activation, we recorded capsaicin- and proton-induced mouse TRPV1 channel currents in a heterologous expression system.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	44-49
34093200-5	2021	To understand the voltage-dependency of the TRPV1 channel activation, we recorded capsaicin- and proton-induced mouse TRPV1 channel currents in a heterologous expression system.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	118-123
34093200-9	2021	These results suggest that the TRPV1 channel slowly drives the feed-forward cycle of pain sensation, and capsaicin and protons differently modulate the voltage-dependent TRPV1 channel gating.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
34093200-9	2021	These results suggest that the TRPV1 channel slowly drives the feed-forward cycle of pain sensation, and capsaicin and protons differently modulate the voltage-dependent TRPV1 channel gating.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	170-175
35247474-9	2022	In addition, the intracellular Ca2+ concentration of 16HBE cells pretreated with MXGSD medicated serum was also tested after stimulation with the TRPV1 agonist capsaicin.	Capsaicin	160-169	transient receptor potential cation channel subfamily V member 1	Homo sapiens	146-151
35349832-0	2022	Capsaicin ameliorates renal fibrosis by inhibiting TGF-beta1-Smad2/3 signaling.	Capsaicin	0-9	transforming growth factor, beta 1	Mus musculus	51-60
35349832-0	2022	Capsaicin ameliorates renal fibrosis by inhibiting TGF-beta1-Smad2/3 signaling.	Capsaicin	0-9	SMAD family member 2	Mus musculus	61-68
35349832-7	2022	RESULTS: Capsaicin treatment significantly alleviated fibronectin and collagen depositions in the tubulointerstitium of the injured kidneys from UUO and adenine-fed mice.	Capsaicin	9-18	fibronectin 1	Mus musculus	54-65
35349832-8	2022	Meanwhile, capsaicin treatment obviously reduced alpha-SMA expression.	Capsaicin	11-20	actin alpha 2, smooth muscle, aorta	Mus musculus	49-58
35349832-9	2022	Moreover, capsaicin treatment dramatically protected against the phenotypic alteration of tubular epithelial cells by increasing E-cadherin expression and decreasing vimentin expression during renal fibrosis.	Capsaicin	10-19	cadherin 1	Mus musculus	129-139
35349832-9	2022	Moreover, capsaicin treatment dramatically protected against the phenotypic alteration of tubular epithelial cells by increasing E-cadherin expression and decreasing vimentin expression during renal fibrosis.	Capsaicin	10-19	vimentin	Mus musculus	166-174
35349832-10	2022	Mechanistically, capsaicin treatment effectively suppressed alpha-SMA and vimentin expressions but promoted E-cadherin expression in HK2 cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	17-26	actin alpha 2, smooth muscle, aorta	Mus musculus	60-69
35349832-10	2022	Mechanistically, capsaicin treatment effectively suppressed alpha-SMA and vimentin expressions but promoted E-cadherin expression in HK2 cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	17-26	vimentin	Mus musculus	74-82
34239123-0	2021	Heat-dependent opening of TRPV1 in the presence of capsaicin.	Capsaicin	51-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-31
34239123-1	2021	Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation channel that serves as the primary heat and capsaicin sensor in humans.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-47
34239123-1	2021	Transient receptor potential vanilloid member 1 (TRPV1) is a Ca2+-permeable cation channel that serves as the primary heat and capsaicin sensor in humans.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
34239123-2	2021	Using cryo-EM, we have determined the structures of apo and capsaicin-bound full-length rat TRPV1 reconstituted into lipid nanodiscs over a range of temperatures.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	92-97
34239123-3	2021	This has allowed us to visualize the noxious heat-induced opening of TRPV1 in the presence of capsaicin.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-74
34898306-7	2021	All neurokinin receptors (NK1-3R) were found to be expressed in a majority of trigeminal ganglion neurons and A-fibres.The functional release of SP and CGRP in the trigeminovascular system was stimulated with either 60 mM K+ or 100 nM capsaicin and measured with an enzyme-linked immunosorbent assay (ELISA).	Capsaicin	235-244	calcitonin-related polypeptide alpha	Rattus norvegicus	152-156
35364116-9	2022	The repetition of Furo/Cap reduced transiently the neutral orofacial responses and ended decreasing the aversive:neutral response ratio to capsaicin.	Capsaicin	139-148	sorbin and SH3 domain containing 1	Rattus norvegicus	23-26
35405615-11	2022	Capsaicin upregulated SIRT1 expression and downregulated the senescence marker, p21, thereby protecting endothelial cells from IHG-induced senescence as indicated by relieved G0/G1 phase arrest, improved cell viabilities, and reduced counts of senescent cells and ROS production.	Capsaicin	0-9	sirtuin 1	Homo sapiens	22-27
35405615-11	2022	Capsaicin upregulated SIRT1 expression and downregulated the senescence marker, p21, thereby protecting endothelial cells from IHG-induced senescence as indicated by relieved G0/G1 phase arrest, improved cell viabilities, and reduced counts of senescent cells and ROS production.	Capsaicin	0-9	H3 histone pseudogene 16	Homo sapiens	80-83
35405615-12	2022	Pre-treatment with CAPZ, BAPTA-AM, KN62 or compound C abrogated the anti-senescence effects of capsaicin.	Capsaicin	95-104	capping actin protein of muscle Z-line subunit alpha 2	Homo sapiens	19-23
35405615-13	2022	Capsaicin restored AMPK phosphorylation and IHG-inhibited TRPV1 expression.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	19-23
35405615-13	2022	Capsaicin restored AMPK phosphorylation and IHG-inhibited TRPV1 expression.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
35405615-14	2022	Moreover, TRPV1 silencing suppressed SIRT1 expression and abolished the anti-senescence effects of capsaicin.	Capsaicin	99-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	10-15
35405615-14	2022	Moreover, TRPV1 silencing suppressed SIRT1 expression and abolished the anti-senescence effects of capsaicin.	Capsaicin	99-108	sirtuin 1	Homo sapiens	37-42
35405615-15	2022	CONCLUSION: Capsaicin elevates SIRT1 levels through TRPV1/(Ca2+)i/CaMKII/AMPK pathway and suppresses IHG-mediated endothelial cell senescence.	Capsaicin	12-21	sirtuin 1	Homo sapiens	31-36
35405615-15	2022	CONCLUSION: Capsaicin elevates SIRT1 levels through TRPV1/(Ca2+)i/CaMKII/AMPK pathway and suppresses IHG-mediated endothelial cell senescence.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
35405615-15	2022	CONCLUSION: Capsaicin elevates SIRT1 levels through TRPV1/(Ca2+)i/CaMKII/AMPK pathway and suppresses IHG-mediated endothelial cell senescence.	Capsaicin	12-21	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	66-72
35405615-15	2022	CONCLUSION: Capsaicin elevates SIRT1 levels through TRPV1/(Ca2+)i/CaMKII/AMPK pathway and suppresses IHG-mediated endothelial cell senescence.	Capsaicin	12-21	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	73-77
35349832-10	2022	Mechanistically, capsaicin treatment effectively suppressed alpha-SMA and vimentin expressions but promoted E-cadherin expression in HK2 cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	17-26	cadherin 1	Mus musculus	108-118
35349832-10	2022	Mechanistically, capsaicin treatment effectively suppressed alpha-SMA and vimentin expressions but promoted E-cadherin expression in HK2 cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	17-26	transforming growth factor, beta 1	Mus musculus	176-185
35349832-10	2022	Mechanistically, capsaicin treatment effectively suppressed alpha-SMA and vimentin expressions but promoted E-cadherin expression in HK2 cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	17-26	SMAD family member 2	Mus musculus	186-193
35405615-0	2022	Capsaicin ameliorates intermittent high glucose-mediated endothelial senescence via the TRPV1/SIRT1 pathway.	Capsaicin	0-9	sirtuin 1	Homo sapiens	94-99
35466105-1	2022	Objective: Capsaicin, the pungent analgesic substance of hot peppers which produces a burning sensation and pain is known to affect Substance P and central opioid activities.	Capsaicin	11-20	tachykinin 1	Mus musculus	132-143
35349832-11	2022	CONCLUSION: Capsaicin significantly ameliorated renal fibrosis possibly by retarding the activation of myofibroblasts and protecting against the phenotypic alteration of tubular epithelial cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	12-21	transforming growth factor, beta 1	Mus musculus	228-237
35349832-11	2022	CONCLUSION: Capsaicin significantly ameliorated renal fibrosis possibly by retarding the activation of myofibroblasts and protecting against the phenotypic alteration of tubular epithelial cells mainly through the inhibition of TGF-beta1-Smad2/3 signaling.	Capsaicin	12-21	SMAD family member 2	Mus musculus	238-245
34996851-7	2022	Preinhaled IFN-gamma (100 microg/mL) increased the capsaicin cough sensitivity in CRC patients but not healthy volunteers.	Capsaicin	51-60	interferon gamma	Homo sapiens	11-20
35499773-6	2022	CONCLUSION: As the overall effect of topical capsaicin application was higher in HS for QST, we suggest the existence of a sensitization of TRPV1 channels in RA patients caused by long-time chronical inflammation, despite a lack of clinical signs of inflammation due to adequate treatment.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	140-145
35626730-5	2022	By contrast, pain behavior induced by the TRP vanilloid 1 (TRPV1) activator capsaicin was normal in Slack-deficient mice.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-57
35626730-5	2022	By contrast, pain behavior induced by the TRP vanilloid 1 (TRPV1) activator capsaicin was normal in Slack-deficient mice.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	59-64
35615576-0	2022	Capsaicin Prevents Contrast-Associated Acute Kidney Injury through Activation of Nrf2 in Mice.	Capsaicin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	81-85
35615576-1	2022	Capsaicin, a transient receptor potential vanilloid 1 channel agonist, possesses antioxidative properties through activating nuclear factor-erythroid 2-related factor 2 (Nrf2).	Capsaicin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	125-168
35615576-1	2022	Capsaicin, a transient receptor potential vanilloid 1 channel agonist, possesses antioxidative properties through activating nuclear factor-erythroid 2-related factor 2 (Nrf2).	Capsaicin	0-9	nuclear factor, erythroid derived 2, like 2	Mus musculus	170-174
35615576-8	2022	The expression of Nrf2 was increased in the kidney from the CA-AKI mouse model and was further enhanced by capsaicin.	Capsaicin	107-116	nuclear factor, erythroid derived 2, like 2	Mus musculus	18-22
35615576-9	2022	Administration of siRNA through the tail vein successfully decreased Nrf2 expression in the kidney, and knockdown of Nrf2 by siRNA abolished the beneficial effects of capsaicin on CA-AKI.	Capsaicin	167-176	nuclear factor, erythroid derived 2, like 2	Mus musculus	69-73
35615576-9	2022	Administration of siRNA through the tail vein successfully decreased Nrf2 expression in the kidney, and knockdown of Nrf2 by siRNA abolished the beneficial effects of capsaicin on CA-AKI.	Capsaicin	167-176	nuclear factor, erythroid derived 2, like 2	Mus musculus	117-121
35615576-10	2022	The present study demonstrated a protective effect of capsaicin pretreatment against CA-AKI via Nrf2.	Capsaicin	54-63	nuclear factor, erythroid derived 2, like 2	Mus musculus	96-100
35563669-8	2022	After capsaicin nanoparticles, itch and nociceptive sensations were reduced in response to pruritogens cowhage, beta-alanine or BAM8-22, but were normal to histamine.	Capsaicin	6-15	adaptor related protein complex 1 subunit beta 1	Homo sapiens	128-135
35473456-4	2022	METHODS: Healthy (BEAS-2B) and cancer-derived (Calu-3) airway epithelial cell lines were assessed for changes to TRPV1 protein expression and mRNA expression following exposure to capsaicin (5-50 microM), and TRPV1 modulators including heat (43  C), and hydrochloric acid (pH 3.4 to pH 6.4).	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-118
35473456-6	2022	Subsequent bronchoconstriction by TRPV1 activation with capsaicin was measured on guinea pig airway tissue to confirm locally mediated activity without the action of known neuronal inputs.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	34-39
35303056-10	2022	CONCLUSIONS: Slick expressed in a subset of sensory neurons modulates heat-induced pain, while Slick expressed in spinal cord interneurons inhibits capsaicin-induced pain but facilitates somatostatin-induced itch.	Capsaicin	148-157	potassium channel, subfamily T, member 2	Mus musculus	95-100
35436739-0	2022	Activation of TRPV1 by capsaicin-loaded CaCO3 nanoparticle for tumor-specific therapy.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
35436739-2	2022	Here, we report an acid-responsive CaCO3 nanoparticle loaded with capsaicin that can specifically activate TRPV1 channels and trigger tumor calcium ion therapy.	Capsaicin	66-75	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
35436739-4	2022	The released capsaicin can specifically activate TRPV1 channel, overloading the intracellular calcium ion concentration and causing cell apoptosis, which provides a new safer and cheaper treatment.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
35232219-0	2022	Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1alpha (Hypoxic-Inducible Factor-1 Alpha).	Capsaicin	0-9	sirtuin 6	Mus musculus	62-67
35232219-0	2022	Capsaicin Attenuates Arterial Calcification Through Promoting SIRT6-Mediated Deacetylation and Degradation of Hif1alpha (Hypoxic-Inducible Factor-1 Alpha).	Capsaicin	0-9	hypoxia inducible factor 1, alpha subunit	Mus musculus	110-119
35232219-2	2022	Capsaicin, the potent agonist of TRPV1 (transient receptor potential vanilloid type 1), was found to mitigate hypoxic-related injury and reverse phenotypic switch of vascular smooth muscle cells.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	33-38
35232219-2	2022	Capsaicin, the potent agonist of TRPV1 (transient receptor potential vanilloid type 1), was found to mitigate hypoxic-related injury and reverse phenotypic switch of vascular smooth muscle cells.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-85
35232219-9	2022	Hif1alpha was increased in Pi-treated vascular smooth muscle cells and its degradation was accelerated by capsaicin.	Capsaicin	106-115	hypoxia inducible factor 1, alpha subunit	Mus musculus	0-9
35232219-10	2022	Retaining Hif1alpha stability using CoCl2 or MG132 abolished the protective effect of capsaicin.	Capsaicin	86-95	hypoxia inducible factor 1, alpha subunit	Mus musculus	10-19
35232219-11	2022	We further identified an increased expression of SIRT6 in response to capsaicin and confirmed the physical interaction between SIRT6 and Hif1alpha.	Capsaicin	70-79	sirtuin 6	Mus musculus	49-54
35232219-11	2022	We further identified an increased expression of SIRT6 in response to capsaicin and confirmed the physical interaction between SIRT6 and Hif1alpha.	Capsaicin	70-79	sirtuin 6	Mus musculus	127-132
35232219-11	2022	We further identified an increased expression of SIRT6 in response to capsaicin and confirmed the physical interaction between SIRT6 and Hif1alpha.	Capsaicin	70-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	137-146
35232219-12	2022	Acetylated Hif1alpha was decreased, whereas hydroxylated Hif1alpha was increased under capsaicin treatment.	Capsaicin	87-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	11-20
35232219-12	2022	Acetylated Hif1alpha was decreased, whereas hydroxylated Hif1alpha was increased under capsaicin treatment.	Capsaicin	87-96	hypoxia inducible factor 1, alpha subunit	Mus musculus	57-66
35232219-13	2022	Using immunohistochemistry analysis, we observed increased SIRT6 and reduced Hif1alpha in both SIRT6 transgenic and capsaicin-treated chronic kidney disease mice.	Capsaicin	116-125	sirtuin 6	Mus musculus	59-64
35232219-13	2022	Using immunohistochemistry analysis, we observed increased SIRT6 and reduced Hif1alpha in both SIRT6 transgenic and capsaicin-treated chronic kidney disease mice.	Capsaicin	116-125	hypoxia inducible factor 1, alpha subunit	Mus musculus	77-86
35232219-14	2022	CONCLUSIONS: Capsaicin facilitates deacetylation and degradation of Hif1alpha by upregulating SIRT6, which inhibits osteogenic transdifferentiation and protects against arterial calcification.	Capsaicin	13-22	hypoxia inducible factor 1, alpha subunit	Mus musculus	68-77
35232219-14	2022	CONCLUSIONS: Capsaicin facilitates deacetylation and degradation of Hif1alpha by upregulating SIRT6, which inhibits osteogenic transdifferentiation and protects against arterial calcification.	Capsaicin	13-22	sirtuin 6	Mus musculus	94-99
35121102-5	2022	The mRNA expression of transient receptor potential vanilloid 1 (TRPV1), a cough sensor activated by capsaicin, in tracheal tissues was determined.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-63
35121102-5	2022	The mRNA expression of transient receptor potential vanilloid 1 (TRPV1), a cough sensor activated by capsaicin, in tracheal tissues was determined.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
35398988-6	2022	The released capsaicin can further activate transient receptor potential cation channel subfamily V member 1 (TRPV1) of U373 cancer cells, leading to an influx of calcium ions into cells.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-108
35398988-6	2022	The released capsaicin can further activate transient receptor potential cation channel subfamily V member 1 (TRPV1) of U373 cancer cells, leading to an influx of calcium ions into cells.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
35599331-9	2022	We showed that metabolic boosting by treatment with the TRPV1 agonist capsaicin rescued metabolic impairments in PFF-tolerant microglia and also defects in mitophagy caused by disruption of the AKT-mTOR-HIF-1alpha pathway.	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	56-61
35599331-9	2022	We showed that metabolic boosting by treatment with the TRPV1 agonist capsaicin rescued metabolic impairments in PFF-tolerant microglia and also defects in mitophagy caused by disruption of the AKT-mTOR-HIF-1alpha pathway.	Capsaicin	70-79	mechanistic target of rapamycin kinase	Mus musculus	198-202
35599331-9	2022	We showed that metabolic boosting by treatment with the TRPV1 agonist capsaicin rescued metabolic impairments in PFF-tolerant microglia and also defects in mitophagy caused by disruption of the AKT-mTOR-HIF-1alpha pathway.	Capsaicin	70-79	hypoxia inducible factor 1, alpha subunit	Mus musculus	203-213
35599331-10	2022	Capsaicin attenuated phosphorylation of alpha-synuclein in primary neurons by boosting phagocytosis in PFF-tolerant microglia in vitro.	Capsaicin	0-9	synuclein, alpha	Mus musculus	40-55
35602097-0	2022	Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	77-82
35602097-0	2022	Capsaicin Alleviates Vascular Endothelial Dysfunction and Cardiomyopathy via TRPV1/eNOS Pathway in Diabetic Rats.	Capsaicin	0-9	nitric oxide synthase 3	Rattus norvegicus	83-87
35602097-2	2022	This study was designed to investigate whether capsaicin (CAP), a selective TRPV1 agonist, could prevent diabetes-induced endothelial dysfunction and cardiomyopathy.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	76-81
35602097-2	2022	This study was designed to investigate whether capsaicin (CAP), a selective TRPV1 agonist, could prevent diabetes-induced endothelial dysfunction and cardiomyopathy.	Capsaicin	58-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	76-81
35602097-9	2022	In addition, CAP enhanced the expression of TRPV1 and eNOS in the heart and normalized the vascular permeability under diabetic state.	Capsaicin	13-16	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	44-49
35602097-9	2022	In addition, CAP enhanced the expression of TRPV1 and eNOS in the heart and normalized the vascular permeability under diabetic state.	Capsaicin	13-16	nitric oxide synthase 3	Rattus norvegicus	54-58
35499773-10	2022	Key Points   The effect of topical capsaicin may represent the extent of TRPV1 sensitization in rheumatoid arthritis.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
35478041-6	2022	Channel-dependent evoked responses were detected using the TRPV1 agonist capsaicin, a TRPA1 agonist, allyl isothiocyanate (AITC), and TRPM8 agonist menthol.	Capsaicin	73-82	transient receptor potential cation channel subfamily V member 1	Homo sapiens	59-64
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	Capsaicin	275-284	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	48-53
35508082-4	2022	METHODS: The three-dimensional structure of the Spike RBD domain of Omicron variant was constructed by incorporating 15 amino acid substitutions to the Native Spike (S) structure and structural changes were compared that of the Native S. Seven phytochemicals namely Allicin, Capsaicin, Cinnamaldehyde, Curcumin, Gingerol, Piperine, and Zingeberene were docked with Omicron S protein and Omicron S-hACE2 complex.	Capsaicin	275-284	surface glycoprotein	Severe acute respiratory syndrome coronavirus 2	159-164
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	nerve growth factor	Rattus norvegicus	53-56
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	brain-derived neurotrophic factor	Rattus norvegicus	59-63
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	70-75
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	121-126
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	nerve growth factor	Rattus norvegicus	128-131
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	brain-derived neurotrophic factor	Rattus norvegicus	133-137
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	148-153
35563108-7	2022	Intraprostatic capsaicin injection induced increased NGF-, BDNF-, and COX-2-positive neurons in the L6 DRG and increased COX-2, NGF, BDNF, receptor Trk-A, and TRPV1 protein expression in the L6 DRG and the dorsal horn of the L6 spinal cord, whose effects were significantly downregulated after Li-ESWT on the prostate.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	159-164
35459786-4	2022	This study showed that the treatment with Capsaicin, an agonist of transient receptor potential vanilloid 1, directly activated adipocyte browning such as UCP1 expression, mitochondrial biogenesis, energy consumption rates, and glycerol recycling in ciBAs.	Capsaicin	42-51	uncoupling protein 1	Homo sapiens	155-159
35459786-6	2022	Capsaicin also activated UCP1 expression in immortalised human brown adipocytes but inhibited its expression in mesenchymal stem cell-derived adipocytes.	Capsaicin	0-9	uncoupling protein 1	Homo sapiens	25-29
35443189-4	2022	PTEN deletion leads to ectopic expression of TRPV1 and MrgprA3 in IB4+ non-peptidergic DRG neurons, and the TRPV1 is responsive to capsaicin.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	108-113
35438378-0	2022	Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells.	Capsaicin	0-9	acyl-CoA synthetase long chain family member 4	Homo sapiens	58-63
35443189-4	2022	PTEN deletion leads to ectopic expression of TRPV1 and MrgprA3 in IB4+ non-peptidergic DRG neurons, and the TRPV1 is responsive to capsaicin.	Capsaicin	131-140	phosphatase and tensin homolog	Mus musculus	0-4
35438378-0	2022	Capsaicin induces redox imbalance and ferroptosis through ACSL4/GPx4 signaling pathways in U87-MG and U251 glioblastoma cells.	Capsaicin	0-9	glutathione peroxidase 4	Homo sapiens	64-68
35438378-10	2022	Treatment of 121.6, 188.5, and 237.2 muM capsaicin concentrations for 24 h indicated an increase in ACSL4, 5-HETE, TOS and MDA levels in U87-MG and U251 cells (p < 0.05).	Capsaicin	41-50	acyl-CoA synthetase long chain family member 4	Homo sapiens	100-105
35438378-11	2022	On the other hand, we found that capsaicin administration caused a decrease in BrdU, GPx4, TAS and GSH levels in U87-MG and U251 cells (p < 0.05).	Capsaicin	33-42	glutathione peroxidase 4	Homo sapiens	85-89
35438378-12	2022	Besides, ACSL4 mRNA and protein levels were increased in the glioblastoma cells treated with capsaicin, whereas GPx4 mRNA and protein levels were decreased.	Capsaicin	93-102	acyl-CoA synthetase long chain family member 4	Homo sapiens	9-14
35183536-8	2022	Capsaicin (100 nM), an agonist of TRPV1 channels, or calcitonin gene-related peptide (CGRP) (30 nM) also slowed and enlarged SPCs.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	34-39
35496916-7	2022	The majority of cells that co-expressed TRPM3 and BKRs also expressed TRPV1, however, only a small fraction co-expressed TRPA1, identified by calcium responses to capsaicin and supercinnamaldehyde, respectively.	Capsaicin	163-172	transient receptor potential cation channel, subfamily M, member 3	Mus musculus	40-45
35496916-7	2022	The majority of cells that co-expressed TRPM3 and BKRs also expressed TRPV1, however, only a small fraction co-expressed TRPA1, identified by calcium responses to capsaicin and supercinnamaldehyde, respectively.	Capsaicin	163-172	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	121-126
35458680-2	2022	The important mechanism of action of capsaicin is its influence on TRPV1 channels in nociceptive sensory neurons.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
35458680-9	2022	These contradictory results may be caused by the fact that capsaicin influences not only TRPV1 channels but also different molecular targets such as voltage-gated sodium channels.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
35183536-9	2022	A prolonged pre-exposure to capsaicin or BIBN4096 (1 muM), a CGRP receptor antagonist, inhibited the mechanostimulation-induced reduction in the SPC frequency, but did not block the increase in SPC amplitude.	Capsaicin	28-37	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	61-65
35183536-9	2022	A prolonged pre-exposure to capsaicin or BIBN4096 (1 muM), a CGRP receptor antagonist, inhibited the mechanostimulation-induced reduction in the SPC frequency, but did not block the increase in SPC amplitude.	Capsaicin	28-37	sparse coat	Mus musculus	145-148
35209831-1	2022	AIM: Aim of the present study is to develop and characterize capsaicin loaded Liposomes film (CAP-Lipofilm) for effective dermal delivery.	Capsaicin	61-70	sorbin and SH3 domain containing 1	Rattus norvegicus	94-97
35189108-6	2022	We determined the behavioral effects of NMB or GRP via acute thermal nociception, capsaicin-induced thermal allodynia, and itch scratching response assays.	Capsaicin	82-91	neuromedin B	Macaca mulatta	40-43
35388300-9	2022	Codonopsis pilosula could upregulate HMOX1 via luteolin, capsaicin, and sulforaphane.	Capsaicin	57-66	heme oxygenase 1	Homo sapiens	37-42
35350319-5	2022	We demonstrate that endogenous TRPV1 is functional and causes Ca2+ influx upon activation with pharmacological activators (resiniferatoxin (RTX) and capsaicin) at nanomolar concentration, which enhances the generation of osteoclasts, whereas the TRPV1 inhibitor (5"-IRTX) reduces osteoclast differentiation.	Capsaicin	149-158	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
35350319-5	2022	We demonstrate that endogenous TRPV1 is functional and causes Ca2+ influx upon activation with pharmacological activators (resiniferatoxin (RTX) and capsaicin) at nanomolar concentration, which enhances the generation of osteoclasts, whereas the TRPV1 inhibitor (5"-IRTX) reduces osteoclast differentiation.	Capsaicin	149-158	transient receptor potential cation channel subfamily V member 1	Homo sapiens	246-251
35350319-7	2022	The slow release of capsaicin or RTX at a nanomolar concentration from a polysaccharide-based hydrogel enhances bone marrow macrophage (BMM) differentiation into osteoclasts whereas release of 5"-IRTX, an inhibitor of TRPV1, prevents macrophage fusion and osteoclast formation.	Capsaicin	20-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	218-223
35260737-5	2022	The percent of retrograde labeled TG neurons that respond to TRPV1 agonist, capsaicin, is increased along with the magnitude of response as measured by calcium influx, in neurons from the cancer models.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	61-66
35107027-6	2022	Activation of TRPV1 with capsaicin caused a biphasic increase in surface pressure, while activation of TRPV4 with GSK1016790A caused a biphasic decrease in pressure.	Capsaicin	25-34	TRPV1	Bos taurus	14-19
35303056-8	2022	In the spinal dorsal horn, Slick is colocalized with somatostatin receptor 2 (SSTR2), and intrathecal preadministration of the SSTR2 antagonist CYN-154806 prevented increased capsaicin-induced licking in Slick-/- and Lbx1-Slick-/- mice.	Capsaicin	175-184	potassium channel, subfamily T, member 2	Mus musculus	27-32
35303056-8	2022	In the spinal dorsal horn, Slick is colocalized with somatostatin receptor 2 (SSTR2), and intrathecal preadministration of the SSTR2 antagonist CYN-154806 prevented increased capsaicin-induced licking in Slick-/- and Lbx1-Slick-/- mice.	Capsaicin	175-184	somatostatin receptor 2	Mus musculus	78-83
35303056-8	2022	In the spinal dorsal horn, Slick is colocalized with somatostatin receptor 2 (SSTR2), and intrathecal preadministration of the SSTR2 antagonist CYN-154806 prevented increased capsaicin-induced licking in Slick-/- and Lbx1-Slick-/- mice.	Capsaicin	175-184	somatostatin receptor 2	Mus musculus	127-132
35400013-0	2022	Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice.	Capsaicin	0-9	interleukin 31	Mus musculus	21-35
35400013-0	2022	Capsaicin suppresses interleukin-31-induced itching partially involved in inhibiting the expression of dorsal root ganglion interleukin-31 receptor A in male mice.	Capsaicin	0-9	interleukin 31 receptor A	Mus musculus	124-149
35400013-3	2022	Total long-lasting scratching and short-lasting scratching counts for 24 h and IL-31RA mRNA expression in the DRG significantly decreased with increasing concentration of capsaicin.	Capsaicin	171-180	interleukin 31 receptor A	Mus musculus	79-86
35400013-4	2022	Furthermore, 1.0% capsaicin suppressed long-lasting scratching and short-lasting scratching for more than 72 h. At this point, DRG IL-31RAmRNA was significantly decreased, but there was no change in cutaneous IL-31RA and TRPV1 mRNA.	Capsaicin	18-27	interleukin 31 receptor A	Mus musculus	209-216
35400013-4	2022	Furthermore, 1.0% capsaicin suppressed long-lasting scratching and short-lasting scratching for more than 72 h. At this point, DRG IL-31RAmRNA was significantly decreased, but there was no change in cutaneous IL-31RA and TRPV1 mRNA.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	221-226
35400013-5	2022	Thus capsaicin suppresses long-lasting scratching by inhibiting IL-31RA mRNA expression in the DRG.	Capsaicin	5-14	interleukin 31 receptor A	Mus musculus	64-71
35400013-9	2022	TRPV1 mRNA in the DRG was also decreased within 1-24 h after capsaicin application.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
35400013-10	2022	These results suggest that the strong and prolonged antipruritic action for IL-31-induced itching of capsaicin was caused by desensitization of C-fibers, and, in addition, the long-lasting inhibition of IL-31RA mRNA expression in the DRG.	Capsaicin	101-110	interleukin 31 receptor A	Mus musculus	203-210
35370565-6	2022	Capsaicin, a specific agonist known to activated the transient receptor potential vanilloid type 1 (TRPV1), is involved in hippocampal synaptic plasticity and memory, but the detailed mechanism is still unclear.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	53-98
35370565-6	2022	Capsaicin, a specific agonist known to activated the transient receptor potential vanilloid type 1 (TRPV1), is involved in hippocampal synaptic plasticity and memory, but the detailed mechanism is still unclear.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	100-105
35280525-1	2022	Transient receptor potential vanilloid 1 (TRPV1) is known as a receptor of capsaicin, a spicy ingredient of chili peppers.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
35280525-5	2022	Except for vanillin, four vanilloid analogues dose-dependently increased (Ca2+)i in mTRPV1-HEK.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	84-90
35280525-9	2022	VAcid, VMA, and vanillin suppressed the activation of TRPV1 induced by capsaicin.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	54-59
35280525-11	2022	In sensory neurons, VMA diminished TRPV1 activation by capsaicin or acids.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	35-40
35189809-4	2022	CGRP release was induced by either 60 mM K+ (for depolarization-induced stimulation) or 100 nM capsaicin (for transient receptor potential vanilloid 1 (TRPV1) -induced stimulation) and measured using an enzyme-linked immunosorbent assay.	Capsaicin	95-104	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
35212819-4	2022	PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS).	Capsaicin	193-202	phosphofurin acidic cluster sorting protein 2	Homo sapiens	0-5
35212819-4	2022	PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS).	Capsaicin	193-202	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-120
35212819-4	2022	PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS).	Capsaicin	193-202	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
35212819-4	2022	PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS).	Capsaicin	193-202	transient receptor potential cation channel subfamily V member 1	Homo sapiens	171-176
35212819-4	2022	PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS).	Capsaicin	204-207	phosphofurin acidic cluster sorting protein 2	Homo sapiens	0-5
35212819-4	2022	PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS).	Capsaicin	204-207	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-120
35212819-4	2022	PACS2 levels are influenced by its interaction with the transient receptor potential cation channel subfamily V member 1 (TRPV1) and can be experimentally modified by the TRPV1-modulating drug capsaicin (CPS).	Capsaicin	204-207	transient receptor potential cation channel subfamily V member 1	Homo sapiens	171-176
35212819-5	2022	Employing alveolar epithelial cells with overexpression of the terminal ER stress signaling factor Chop or the IPF-associated surfactant protein C mutation (SPCDeltaexon4) in vitro, we observed a restoration of PACS2 levels upon treatment with CPS.	Capsaicin	244-247	DNA damage inducible transcript 3	Homo sapiens	99-103
35189809-4	2022	CGRP release was induced by either 60 mM K+ (for depolarization-induced stimulation) or 100 nM capsaicin (for transient receptor potential vanilloid 1 (TRPV1) -induced stimulation) and measured using an enzyme-linked immunosorbent assay.	Capsaicin	95-104	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	152-157
35177004-5	2022	The functional role of these receptors was examined ex vivo with a capsaicin/potassium induced 5-HT and CGRP release.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	104-108
35228812-11	2022	The sole effect of WAS exposure or ET-1 administration on the micturition reflex could be suppressed by capsaicin pretreatment.	Capsaicin	104-113	endothelin 1	Rattus norvegicus	35-39
35228812-15	2022	Conclusion: The activation of ET-1 receptors could enhance chronic stress-induced bladder hypersensitization and hyperalgesia through capsaicin-sensitive C-fiber afferents.	Capsaicin	134-143	endothelin 1	Rattus norvegicus	30-34
35216322-2	2022	In this study, we assessed the capsaicin- or zinc- induced activation of signalling molecules including calcium/calmodulin-dependent protein kinase 2 (CAMKK2), cAMP-response element-binding protein (CREB), and target of rapamycin kinase complex 1 (TORC1).	Capsaicin	31-40	calcium/calmodulin-dependent protein kinase kinase 2, beta	Mus musculus	151-157
35216322-2	2022	In this study, we assessed the capsaicin- or zinc- induced activation of signalling molecules including calcium/calmodulin-dependent protein kinase 2 (CAMKK2), cAMP-response element-binding protein (CREB), and target of rapamycin kinase complex 1 (TORC1).	Capsaicin	31-40	cAMP responsive element binding protein 1	Mus musculus	160-197
35216322-2	2022	In this study, we assessed the capsaicin- or zinc- induced activation of signalling molecules including calcium/calmodulin-dependent protein kinase 2 (CAMKK2), cAMP-response element-binding protein (CREB), and target of rapamycin kinase complex 1 (TORC1).	Capsaicin	31-40	cAMP responsive element binding protein 1	Mus musculus	199-203
35216322-2	2022	In this study, we assessed the capsaicin- or zinc- induced activation of signalling molecules including calcium/calmodulin-dependent protein kinase 2 (CAMKK2), cAMP-response element-binding protein (CREB), and target of rapamycin kinase complex 1 (TORC1).	Capsaicin	31-40	CREB regulated transcription coactivator 1	Mus musculus	210-246
35216322-2	2022	In this study, we assessed the capsaicin- or zinc- induced activation of signalling molecules including calcium/calmodulin-dependent protein kinase 2 (CAMKK2), cAMP-response element-binding protein (CREB), and target of rapamycin kinase complex 1 (TORC1).	Capsaicin	31-40	CREB regulated transcription coactivator 1	Mus musculus	248-253
35163843-8	2022	TRPA1 and TRPV1 activation (100 microM AITC, 100 nM capsaicin) induced 45Ca2+-influx into PE/CA-PJ41 cells.	Capsaicin	52-61	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
35163843-8	2022	TRPA1 and TRPV1 activation (100 microM AITC, 100 nM capsaicin) induced 45Ca2+-influx into PE/CA-PJ41 cells.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	10-15
35163843-6	2022	Radioactive 45Ca2+ uptake and ATP-based luminescence indicating cell viability were measured in PE/CA-PJ41 cells in response to the TRPA1 agonist allyl-isothiocyanate (AITC) and TRPV1 agonist capsaicin to determine receptor function.	Capsaicin	192-201	transient receptor potential cation channel subfamily A member 1	Homo sapiens	132-137
35163843-6	2022	Radioactive 45Ca2+ uptake and ATP-based luminescence indicating cell viability were measured in PE/CA-PJ41 cells in response to the TRPA1 agonist allyl-isothiocyanate (AITC) and TRPV1 agonist capsaicin to determine receptor function.	Capsaicin	192-201	transient receptor potential cation channel subfamily V member 1	Homo sapiens	178-183
35109876-16	2022	Consistent with the analgesic effect, MaR1 inhibited capsaicin-elicited TRPV1 currents, repressed the nerve injury-induced activation of spinal microglia and astrocytes and reduced the production of proinflammatory cytokines in the spinal cord dorsal horn in PNI mice.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	72-77
35063502-9	2022	This study revealed that pentobarbital functions between the activation of vanilloid receptor subtype 1 (TRPV1) receptors, to which capsaicin selectively binds, and the opening of voltage-operated Ca2+ channels (VOCC) in the nerve endings.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	75-103
35063502-9	2022	This study revealed that pentobarbital functions between the activation of vanilloid receptor subtype 1 (TRPV1) receptors, to which capsaicin selectively binds, and the opening of voltage-operated Ca2+ channels (VOCC) in the nerve endings.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	105-110
35197406-10	2022	The inhibition of TRPV1 by 5"-iRTX in HG/HF group elevated the reactive oxygen species (ROS) levels, whereas TRPV1 agonist capsaicin reduced ROS.	Capsaicin	123-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	109-114
35121697-8	2022	Further, E2 receptors co-expressed with 5HT2A and TRPV1 and enhanced capsaicin-evoked signaling in the trigeminal ganglia via ERalpha.	Capsaicin	69-78	estrogen receptor 1	Rattus norvegicus	126-133
34967443-10	2022	TRPV1, whose agonist is capsaicin (CAP), is widely expressed on chemically-sensitive metaboreceptors and/or nociceptors.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
34967443-10	2022	TRPV1, whose agonist is capsaicin (CAP), is widely expressed on chemically-sensitive metaboreceptors and/or nociceptors.	Capsaicin	35-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
35115924-4	2021	In this study, pharmacological activation of TRPV1 with the TRPV1 agonist capsaicin induced autophagy in a TRPV1-dependent manner in both primary microglia and BV2 cells.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-50
35345975-0	2022	Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats.	Capsaicin	10-19	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	23-55
35345975-0	2022	Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats.	Capsaicin	10-19	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	57-61
35345975-0	2022	Effect of capsaicin on breast cancer resistance protein (BCRP/Abcg2) and pharmacokinetics of probe substrates in rats.	Capsaicin	10-19	ATP binding cassette subfamily G member 2	Rattus norvegicus	62-67
35345975-2	2022	Capsaicin may have the potential to modulate the function of Bcrp transport.	Capsaicin	0-9	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	61-65
35345975-8	2022	In addition, we found Bcrp mRNA levels and protein expressions in rat livers and intestines were decreased in 3, 8 and 25 mg/kg/d capsaicin-treated groups.Our study demonstrated that long-term ingestion of capsaicin significantly enhanced the AUC of sulfasalazine involved down-regulate Bcrp gene and protein expression in rat liver and intestine.	Capsaicin	130-139	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	22-26
35345975-8	2022	In addition, we found Bcrp mRNA levels and protein expressions in rat livers and intestines were decreased in 3, 8 and 25 mg/kg/d capsaicin-treated groups.Our study demonstrated that long-term ingestion of capsaicin significantly enhanced the AUC of sulfasalazine involved down-regulate Bcrp gene and protein expression in rat liver and intestine.	Capsaicin	130-139	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	287-291
35345975-8	2022	In addition, we found Bcrp mRNA levels and protein expressions in rat livers and intestines were decreased in 3, 8 and 25 mg/kg/d capsaicin-treated groups.Our study demonstrated that long-term ingestion of capsaicin significantly enhanced the AUC of sulfasalazine involved down-regulate Bcrp gene and protein expression in rat liver and intestine.	Capsaicin	206-215	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	22-26
35345975-8	2022	In addition, we found Bcrp mRNA levels and protein expressions in rat livers and intestines were decreased in 3, 8 and 25 mg/kg/d capsaicin-treated groups.Our study demonstrated that long-term ingestion of capsaicin significantly enhanced the AUC of sulfasalazine involved down-regulate Bcrp gene and protein expression in rat liver and intestine.	Capsaicin	206-215	ATP binding cassette subfamily G member 2 (Junior blood group)	Homo sapiens	287-291
35214061-0	2022	The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells.	Capsaicin	29-38	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	49-53
35214061-0	2022	The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells.	Capsaicin	29-38	serine/threonine kinase 11	Homo sapiens	62-66
35214061-0	2022	The Natural Chemotherapeutic Capsaicin Activates AMPK through LKB1 Kinase and TRPV1 Receptors in Prostate Cancer Cells.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	78-83
35214061-3	2022	We found that capsaicin activated AMP-activated kinase (AMPK) and promoted cell death in the LKB1-expressing prostate cancer cell lines LNCaP and PC3, but not in the liver kinase B1 (LKB1)-null cell line DU-145.	Capsaicin	14-23	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	34-54
35214061-3	2022	We found that capsaicin activated AMP-activated kinase (AMPK) and promoted cell death in the LKB1-expressing prostate cancer cell lines LNCaP and PC3, but not in the liver kinase B1 (LKB1)-null cell line DU-145.	Capsaicin	14-23	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	56-60
35214061-3	2022	We found that capsaicin activated AMP-activated kinase (AMPK) and promoted cell death in the LKB1-expressing prostate cancer cell lines LNCaP and PC3, but not in the liver kinase B1 (LKB1)-null cell line DU-145.	Capsaicin	14-23	serine/threonine kinase 11	Homo sapiens	93-97
35214061-4	2022	Capsaicin treatment stimulated LKB1 phosphorylation and activated AMPK in LKB1-expressing cells.	Capsaicin	0-9	serine/threonine kinase 11	Homo sapiens	31-35
35214061-4	2022	Capsaicin treatment stimulated LKB1 phosphorylation and activated AMPK in LKB1-expressing cells.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	66-70
35214061-4	2022	Capsaicin treatment stimulated LKB1 phosphorylation and activated AMPK in LKB1-expressing cells.	Capsaicin	0-9	serine/threonine kinase 11	Homo sapiens	74-78
35214061-5	2022	In addition, LKB1 silencing in LNCaP and PC3 cells abrogated capsaicin-induced AMPK activation, while the overexpression of LKB1 by lentiviral infection in DU-145 cells induced capsaicin-triggered AMPK phosphorylation.	Capsaicin	61-70	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	79-83
35214061-5	2022	In addition, LKB1 silencing in LNCaP and PC3 cells abrogated capsaicin-induced AMPK activation, while the overexpression of LKB1 by lentiviral infection in DU-145 cells induced capsaicin-triggered AMPK phosphorylation.	Capsaicin	61-70	serine/threonine kinase 11	Homo sapiens	124-128
35214061-5	2022	In addition, LKB1 silencing in LNCaP and PC3 cells abrogated capsaicin-induced AMPK activation, while the overexpression of LKB1 by lentiviral infection in DU-145 cells induced capsaicin-triggered AMPK phosphorylation.	Capsaicin	177-186	serine/threonine kinase 11	Homo sapiens	124-128
35214061-7	2022	Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells.	Capsaicin	0-9	serine/threonine kinase 11	Homo sapiens	18-22
35214061-7	2022	Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-124
35214061-7	2022	Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	126-131
35214061-7	2022	Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	140-145
35214061-7	2022	Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells.	Capsaicin	0-9	serine/threonine kinase 11	Homo sapiens	178-182
35214061-7	2022	Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	187-191
35214061-7	2022	Capsaicin-induced LKB1 phosphorylation was dependent on the transient receptor potential cation channel subfamily V member 1 (TRPV1), since TRPV1 knocked down by shRNA abolished LKB1 and AMPK phosphorylation in LKB1-expressing cells.	Capsaicin	0-9	serine/threonine kinase 11	Homo sapiens	211-215
35214061-8	2022	Altogether, our results showed that capsaicin affected AMPK activity in an LKB1- and TRPV1-dependent fashion, linking TRPV1 with cell fate.	Capsaicin	36-45	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	55-59
35214061-8	2022	Altogether, our results showed that capsaicin affected AMPK activity in an LKB1- and TRPV1-dependent fashion, linking TRPV1 with cell fate.	Capsaicin	36-45	serine/threonine kinase 11	Homo sapiens	75-79
35214061-8	2022	Altogether, our results showed that capsaicin affected AMPK activity in an LKB1- and TRPV1-dependent fashion, linking TRPV1 with cell fate.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-90
35214061-8	2022	Altogether, our results showed that capsaicin affected AMPK activity in an LKB1- and TRPV1-dependent fashion, linking TRPV1 with cell fate.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
35163091-4	2022	The IK(A) amplitude in these cells was sensitive to attenuation by the application of 4-aminopyridine, 4-aminopyridine-3-methanol, or capsaicin but not by that of tetraethylammonium chloride.	Capsaicin	134-143	IK cytokine	Rattus norvegicus	4-6
35140545-1	2022	An integrated method combining network pharmacology and in vivo experiment was performed to investigate the therapeutic mechanism of capsaicin (Cap) against acute lung injury.	Capsaicin	133-142	sorbin and SH3 domain containing 1	Rattus norvegicus	144-147
34751390-0	2022	Capsaicin restores sodium iodine symporter-mediated radioiodine uptake through bypassing canonical TSH-TSHR pathway in anaplastic thyroid carcinoma cells.	Capsaicin	0-9	thyroid stimulating hormone receptor	Homo sapiens	103-107
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-101
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	22-31	transcription termination factor 1	Homo sapiens	252-257
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	22-31	transcription termination factor 2	Homo sapiens	259-264
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	22-31	paired box 8	Homo sapiens	270-274
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	22-31	thyroid stimulating hormone receptor	Homo sapiens	320-356
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	22-31	thyroid stimulating hormone receptor	Homo sapiens	358-362
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	33-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-101
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	33-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	33-36	transcription termination factor 1	Homo sapiens	252-257
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	33-36	transcription termination factor 2	Homo sapiens	259-264
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	33-36	paired box 8	Homo sapiens	270-274
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	33-36	thyroid stimulating hormone receptor	Homo sapiens	320-356
34751390-5	2022	In the present study, capsaicin (CAP), a natural potent transient receptor potential vanilloid type 1 (TRPV1) agonist, was discovered to re-induce ATC cell differentiation and to increase the expression of thyroid transcription factors (TTFs including TTF-1, TTF-2, and PAX8) and iodine-metabolizing proteins, including thyroid stimulating hormone receptor (TSHR), thyroid peroxidase, and sodium iodine symporter (NIS), in two ATC cell lines, 8505C and FRO.	Capsaicin	33-36	thyroid stimulating hormone receptor	Homo sapiens	358-362
35115924-4	2021	In this study, pharmacological activation of TRPV1 with the TRPV1 agonist capsaicin induced autophagy in a TRPV1-dependent manner in both primary microglia and BV2 cells.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-65
35115924-4	2021	In this study, pharmacological activation of TRPV1 with the TRPV1 agonist capsaicin induced autophagy in a TRPV1-dependent manner in both primary microglia and BV2 cells.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
35115924-6	2021	TRPV1 agonist capsaicin decreased amyloid and phosphorylated tau pathology and reversed memory deficits by promoting microglia activation, metabolism, and autophagy in 3xTg mice.	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
35115924-7	2021	These results indicate that TRPV1 was a potential therapeutic target for AD, which suggests that capsaicin should be further assessed as a possible treatment for AD.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-33
35055082-0	2022	NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases.	Capsaicin	36-45	nerve growth factor	Rattus norvegicus	0-3
35095413-7	2021	Moreover, the pharmacological analysis showed the involvement of histamine, mast cells, opioid receptors, and capsaicin-sensitive C-fibers in Zn2+-induced acute itch in mice.	Capsaicin	110-119	itchy, E3 ubiquitin protein ligase	Mus musculus	161-165
35012445-10	2022	Application of Yoda1, an agonist of Piezo1 channels, or capsaicin activating TRPV1 channels, although also leading to increased nociceptive firing of meningeal fibres, did not reveal a sex difference.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	77-82
35573151-0	2022	Pathophysiological Role of TLR4 in Chronic Relapsing Itch Induced by Subcutaneous Capsaicin Injection in Neonatal Rats.	Capsaicin	82-91	toll-like receptor 4	Rattus norvegicus	27-31
35573151-0	2022	Pathophysiological Role of TLR4 in Chronic Relapsing Itch Induced by Subcutaneous Capsaicin Injection in Neonatal Rats.	Capsaicin	82-91	itchy E3 ubiquitin protein ligase	Rattus norvegicus	53-57
35573151-6	2022	TLR4 antagonist treatment also restored the density of cutaneous nerve fibers and inhibited the histopathological changes that are associated with mast cell activation after capsaicin injection.	Capsaicin	174-183	toll-like receptor 4	Rattus norvegicus	0-4
35024968-0	2022	The effects of mutation on the drug binding affinity of Neuraminidase: case study of Capsaicin using steered molecular dynamics simulation.	Capsaicin	85-94	neuraminidase 1	Homo sapiens	56-69
35024968-5	2022	In this paper, the binding affinity of an herbal ligand of Capsaicin bound to Neuraminidase of the influenza virus is investigated using steered molecular dynamics (SMD) simulation.	Capsaicin	59-68	neuraminidase 1	Homo sapiens	78-91
35097287-1	2022	Capsaicin, the compound in hot chili peppers responsible for their pungency and an agonist of the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), has long been known to promote the desensitization of nociceptors at high concentrations.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	166-171
35097287-5	2022	Analogues reported in this paper add to and show some differences from previous structure-activity relationship (SAR) studies of capsaicin-like molecules against TRPV1, including the necessity of phenol in the aromatic "A-region", the secondary amide in the "B-region", and modifications in the hydrophobic "C-region".	Capsaicin	129-138	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	162-167
34996439-3	2022	RESULTS: Here, we report that 1,4-dioxane potentiates the capsaicin-sensitive transient receptor potential (TRP) channel TRPV1, thereby causing hyperalgesia in mouse model.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	121-126
35055082-0	2022	NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases.	Capsaicin	36-45	calcitonin-related polypeptide alpha	Rattus norvegicus	13-17
35055082-0	2022	NGF Enhances CGRP Release Evoked by Capsaicin from Rat Trigeminal Neurons: Differential Inhibition by SNAP-25-Cleaving Proteases.	Capsaicin	36-45	synaptosome associated protein 25	Rattus norvegicus	102-109
35055082-2	2022	Towards this goal, cultured neurons from neonatal rat trigeminal ganglia-a locus for craniofacial sensory nerves-were used to examine how NGF affects the Ca2+-dependent release of a pain mediator, calcitonin gene-related peptide (CGRP), that is triggered by activating a key signal transducer, transient receptor potential vanilloid 1 (TRPV1) with capsaicin (CAP).	Capsaicin	348-357	calcitonin-related polypeptide alpha	Rattus norvegicus	197-228
35055082-2	2022	Towards this goal, cultured neurons from neonatal rat trigeminal ganglia-a locus for craniofacial sensory nerves-were used to examine how NGF affects the Ca2+-dependent release of a pain mediator, calcitonin gene-related peptide (CGRP), that is triggered by activating a key signal transducer, transient receptor potential vanilloid 1 (TRPV1) with capsaicin (CAP).	Capsaicin	359-362	calcitonin-related polypeptide alpha	Rattus norvegicus	197-228
35057413-1	2022	Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-70
35071508-1	2022	BACKGROUND: Transient receptor potential vanilloid-1 (TRPV1), a nonselective cation channel, is activated by capsaicin, a pungent ingredient of hot pepper.	Capsaicin	109-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	54-59
35071508-2	2022	Previous studies have suggested a link between obesity and capsaicin-associated pathways, and activation of TRPV1 may provide an alternative approach for obesity treatment.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	108-113
35057413-1	2022	Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
35057413-1	2022	Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-70
35057413-1	2022	Capsaicin (CAP) activates the transient receptor potential vanilloid 1 (TRPV1) channel on sensory neurons, improving ATP production, vascular function, fatigue resistance, and thus exercise performance.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
2589542-0	1989	Capsaicin attenuates hindbrain neuron responses to circulating cholecystokinin.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	63-78
2690648-0	1989	Synthetic capsaicin reversibly impairs vasopressin-mediated blood pressure recovery.	Capsaicin	10-19	arginine vasopressin	Rattus norvegicus	39-50
2690648-1	1989	The vasopressin-mediated recovery of arterial pressure observed in adult rats following pharmacological blockade of the sympathetic nervous and renin-angiotensin systems is reduced by neonatal capsaicin treatment.	Capsaicin	193-202	arginine vasopressin	Rattus norvegicus	4-15
2690648-1	1989	The vasopressin-mediated recovery of arterial pressure observed in adult rats following pharmacological blockade of the sympathetic nervous and renin-angiotensin systems is reduced by neonatal capsaicin treatment.	Capsaicin	193-202	renin	Rattus norvegicus	144-149
2699355-4	1989	(3) Pharmacological blockade of the renin-angiotensin-system with captopril induced a more pronounced hypotonia in capsaicin-pretreated than in control rats.	Capsaicin	115-124	renin	Rattus norvegicus	36-41
2589542-2	1989	Capsaicin treatment attenuates suppression of food intake induced by systemic administration of cholecystokinin (CCK) but not by gastric distension.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	96-111
2589542-2	1989	Capsaicin treatment attenuates suppression of food intake induced by systemic administration of cholecystokinin (CCK) but not by gastric distension.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	113-116
2589542-4	1989	Therefore, it is plausible that some hindbrain neurons receive convergent input from capsaicin-sensitive vagal neurons that are responsive to CCK and also from capsaicin-insensitive neurons that are responsive to gastric distension.	Capsaicin	85-94	cholecystokinin	Rattus norvegicus	142-145
2589542-6	1989	We found that capsaicin-pretreated rats exhibit attenuated neuronal discharge responses to CCK-8 but not to gastric distension.	Capsaicin	14-23	cholecystokinin	Rattus norvegicus	91-94
2480171-0	1989	Capsaicin evokes secretion of nasal fluid and depletes substance P and calcitonin gene-related peptide from the nasal mucosa in the rat.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	71-102
2480171-10	1989	The concentrations of SP and CGRP in the nasal mucosa were reduced by capsaicin 6 days after topical or s.c. administration but not 15 min after topical application of desensitizing doses.	Capsaicin	70-79	calcitonin-related polypeptide alpha	Rattus norvegicus	29-33
2480171-15	1989	In addition, the inhibition of the response to capsaicin by (D-Pro2,D-Trp7,9)-SP and lidocaine and the depletion of SP and CGRP after capsaicin indicate the involvement of tachykinin-mediated axon reflexes.	Capsaicin	134-143	calcitonin-related polypeptide alpha	Rattus norvegicus	123-127
2618762-8	1989	Capsaicin pre-treatment significantly reduced (by about 70%) the tissue levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity (-LI), which is present in sensory nerves, but not neuropeptide Y-LI, which is of sympathetic origin, in the left ventricle of the heart, quadriceps muscle and skin in the pig.	Capsaicin	0-9	Calcitonin gene-related peptide	Sus scrofa	82-113
2482449-13	1989	Although the bradycardia elicited by [beta-Asp4, MePhe7]NKB (4-10) (32.5 nmol/kg) was also blocked by hexamethonium, methylatropine, and by bilateral vagotomy, it remained unaffected after indomethacin, or in rats pretreated with either capsaicin or compound 48/80.	Capsaicin	237-246	tachykinin precursor 3	Rattus norvegicus	56-59
2791226-8	1989	Capsaicin has been suggested to release neurotransmitter and eventually deplete neurons containing substance P and calcitonin gene-related peptide.	Capsaicin	0-9	tachykinin precursor 1	Bos taurus	99-110
2819327-0	1989	Prejunctional modulatory action of neuropeptide Y on peripheral terminals of capsaicin-sensitive sensory nerves.	Capsaicin	77-86	pro-neuropeptide Y	Cavia porcellus	35-49
2819327-2	1989	We have determined the effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated left atria (reserpine-pretreatment, atropine in the bath) and bronchi (atropine and indomethacin in the bath) using capsaicin itself and electrical field stimulation as stimuli.	Capsaicin	99-108	pro-neuropeptide Y	Cavia porcellus	33-47
2819327-2	1989	We have determined the effect of neuropeptide Y (NPY) on motor responses produced by activation of capsaicin-sensitive primary afferents in the guinea-pig isolated left atria (reserpine-pretreatment, atropine in the bath) and bronchi (atropine and indomethacin in the bath) using capsaicin itself and electrical field stimulation as stimuli.	Capsaicin	99-108	pro-neuropeptide Y	Cavia porcellus	49-52
2819327-8	1989	We conclude that NPY exerts a prejunctional inhibitory action on transmitter release from peripheral endings of capsaicin-sensitive nerves.	Capsaicin	112-121	pro-neuropeptide Y	Cavia porcellus	17-20
2618762-8	1989	Capsaicin pre-treatment significantly reduced (by about 70%) the tissue levels of calcitonin gene-related peptide (CGRP)-like immunoreactivity (-LI), which is present in sensory nerves, but not neuropeptide Y-LI, which is of sympathetic origin, in the left ventricle of the heart, quadriceps muscle and skin in the pig.	Capsaicin	0-9	Calcitonin gene-related peptide	Sus scrofa	115-119
2681965-1	1989	Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
2681965-1	1989	Calcitonin gene-related peptide (CGRP) is localized in capsaicin-sensitive nerve fibres in the kidney and urogenital tract whereas calcitonin reaches the kidney through the general circulation.	Capsaicin	55-64	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
2481846-0	1989	Capsaicin-sensitive primary afferents are involved in the hypotensive effect of neurotensin in ganglion-blocked guinea pigs.	Capsaicin	0-9	neurotensin/neuromedin N	Cavia porcellus	80-91
2758231-6	1989	In rats pretreated with capsaicin 2 weeks prior to study, to induce a functional ablation of primary afferent neurones, gastric damage induced by Paf was significantly augmented.	Capsaicin	24-33	PCNA clamp associated factor	Rattus norvegicus	146-149
2813292-1	1989	Capsaicin injected intrathecally releases substance P from primary sensory nerve endings, and induces a pain related behaviour in mice consisting of licking, biting and scratching directed to the distal part of the body.	Capsaicin	0-9	tachykinin 1	Mus musculus	42-53
2476911-0	1989	Capsaicin-induced vasodilatation of human coronary arteries in vitro is mediated by calcitonin gene-related peptide rather than substance P or neurokinin A.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	84-115
2476911-0	1989	Capsaicin-induced vasodilatation of human coronary arteries in vitro is mediated by calcitonin gene-related peptide rather than substance P or neurokinin A.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	128-139
2476911-11	1989	Thus, CGRP but not SP mimics the vasodilatory effects of capsaicin on human coronary arteries.	Capsaicin	57-66	calcitonin related polypeptide alpha	Homo sapiens	6-10
2477101-14	1989	The bladder of capsaicin-pretreated rats increased in weight (21%) and in VIP content (31%), while the content of SP and CGRP was reduced by 86 and 94%, respectively.	Capsaicin	15-24	vasoactive intestinal peptide	Rattus norvegicus	74-77
2477101-14	1989	The bladder of capsaicin-pretreated rats increased in weight (21%) and in VIP content (31%), while the content of SP and CGRP was reduced by 86 and 94%, respectively.	Capsaicin	15-24	calcitonin-related polypeptide alpha	Rattus norvegicus	121-125
2759179-0	1989	5-HT3 receptor binding sites are on capsaicin-sensitive fibres in the rat spinal cord.	Capsaicin	36-45	5-hydroxytryptamine receptor 3A	Rattus norvegicus	0-14
2787209-9	1989	In conclusion, the morphological findings of co-localization of CGRP-LI and SP-LI in capsaicin-sensitive nerve fibers of the nasal mucosa and trigeminal ganglia of different species including man, coupled with the in vivo description of the high vasodilator potency of CGRP and tachykinins, imply co-release of several vasoactive agents upon activation of the nasal sensory nerves.	Capsaicin	85-94	calcitonin related polypeptide alpha	Homo sapiens	64-68
2471719-2	1989	We have assessed the effect of topical capsaicin pretreatment on the responses to intradermal injections of histamine and platelet-activating factor (PAF) in six normal subjects, and of prostaglandin E2, histamine, and antigen in 10 atopic subjects.	Capsaicin	39-48	PCNA clamp associated factor	Homo sapiens	122-148
2471719-2	1989	We have assessed the effect of topical capsaicin pretreatment on the responses to intradermal injections of histamine and platelet-activating factor (PAF) in six normal subjects, and of prostaglandin E2, histamine, and antigen in 10 atopic subjects.	Capsaicin	39-48	PCNA clamp associated factor	Homo sapiens	150-153
2484287-4	1989	This stimulation is inhibited by the substance P and substance K antagonist spantide, while capsaicin, a pungent agent of capsicum peppers that destroys sensory neurons, stimulates cell division, probably through release of substance P.	Capsaicin	92-101	tachykinin precursor 1	Homo sapiens	37-48
2484287-4	1989	This stimulation is inhibited by the substance P and substance K antagonist spantide, while capsaicin, a pungent agent of capsicum peppers that destroys sensory neurons, stimulates cell division, probably through release of substance P.	Capsaicin	92-101	tachykinin precursor 1	Homo sapiens	224-235
2787209-6	1989	The nasal CGRP-IR nerves disappeared after capsaicin pretreatment in the guinea pig.	Capsaicin	43-52	calcitonin related polypeptide alpha	Homo sapiens	10-14
2482356-6	1989	In ganglia which were removed from animals which had been pre-treated with capsaicin, transient responses to neurotensin were virtually abolished.	Capsaicin	75-84	neurotensin/neuromedin N	Cavia porcellus	109-120
2470121-10	1989	This indicates that capsaicin produced a relaxation of indomethacin-treated strip by releasing a hyperpolarizing endothelial factor and probably endogenous CGRP.	Capsaicin	20-29	Calcitonin gene-related peptide	Sus scrofa	156-160
2600834-2	1989	We have attempted to determine the origin of a potent circulating vasodilator, calcitonin gene-related peptide (CGRP), by assessing the effects of administration of capsaicin and colchicine, and of thyroidectomy on plasma levels.	Capsaicin	165-174	calcitonin-related polypeptide alpha	Rattus norvegicus	79-110
2600834-2	1989	We have attempted to determine the origin of a potent circulating vasodilator, calcitonin gene-related peptide (CGRP), by assessing the effects of administration of capsaicin and colchicine, and of thyroidectomy on plasma levels.	Capsaicin	165-174	calcitonin-related polypeptide alpha	Rattus norvegicus	112-116
2600834-5	1989	Seven minutes following the intraperitoneal injection of capsaicin (10 mg/kg body weight) plasma CGRP and neurokinin A levels were found to rise by 15- and 4-fold respectively, while there was no change in circulating calcitonin levels.	Capsaicin	57-66	calcitonin-related polypeptide alpha	Rattus norvegicus	97-101
2600834-6	1989	Chromatography revealed that the immunochemical forms of CGRP released into the circulation by capsaicin were similar to those found in normal plasma, which included a peak co-eluting with the intact CGRP molecule.	Capsaicin	95-104	calcitonin-related polypeptide alpha	Rattus norvegicus	57-61
2600834-11	1989	The magnitude of capsaicin-evoked elevation of plasma CGRP was only marginally (significant at 0.1 greater than P greater than 0.05) reduced by pre-treatment with colchicine.	Capsaicin	17-26	calcitonin-related polypeptide alpha	Rattus norvegicus	54-58
2786168-0	1989	Release of VIP- but not CGRP-like immunoreactivity by capsaicin from the human isolated small intestine.	Capsaicin	54-63	vasoactive intestinal peptide	Homo sapiens	11-14
2786168-1	1989	Exposure to capsaicin (1 microM) produced a prompt and sustained release of vasoactive intestinal polypeptide-like immunoreactivity (VIP-LI) from mucosa-free strips of human small intestine (jejunum and ileum).	Capsaicin	12-21	vasoactive intestinal peptide	Homo sapiens	133-136
2467519-12	1989	In conclusion, SP and CGRP mimicked capsaicin-induced vasodilation in the tracheobronchial circulation while VIP had a preferential effect on the tracheal circulation.	Capsaicin	36-45	Calcitonin gene-related peptide	Sus scrofa	22-26
2784250-0	1989	Differential release of calcitonin gene-related peptide and neuropeptide Y from the isolated heart by capsaicin, ischaemia, nicotine, bradykinin and ouabain.	Capsaicin	102-111	pro-neuropeptide Y	Cavia porcellus	60-74
2465514-0	1989	Developmental alterations in thermal nociceptive threshold and the distribution of immunoreactive calcitonin gene-related peptide and substance P after neonatal administration of capsaicin in the rat.	Capsaicin	179-188	calcitonin-related polypeptide alpha	Rattus norvegicus	98-129
2784250-12	1989	Activation of cardiac sensory nerves by capsaicin, nicotine, bradykinin and ouabain, as well as ischaemia, induced release of CGRP while nicotine also evoked NPY release.	Capsaicin	40-49	pro-neuropeptide Y	Cavia porcellus	158-161
2783973-7	1989	CGRP-like immunoreactivity was depleted considerably by treatment of the tissue with piperine or capsaicin.	Capsaicin	97-106	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2783973-8	1989	When endogenous CGRP was depleted, although the positive chronotropic and inotropic effects of piperine and capsaicin were abolished, the effects of CGRP and isoproterenol were not affected.	Capsaicin	108-117	calcitonin-related polypeptide alpha	Rattus norvegicus	16-20
2783973-9	1989	These results indicate that both piperine and capsaicin cause positive chronotropic and inotropic responses by releasing CGRP from nonadrenergic noncholinergic nerves, and that the development of cross-tachyphylaxis between piperine and capsaicin is due to the depletion of endogenous CGRP.	Capsaicin	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	121-125
2783973-9	1989	These results indicate that both piperine and capsaicin cause positive chronotropic and inotropic responses by releasing CGRP from nonadrenergic noncholinergic nerves, and that the development of cross-tachyphylaxis between piperine and capsaicin is due to the depletion of endogenous CGRP.	Capsaicin	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	285-289
2783973-9	1989	These results indicate that both piperine and capsaicin cause positive chronotropic and inotropic responses by releasing CGRP from nonadrenergic noncholinergic nerves, and that the development of cross-tachyphylaxis between piperine and capsaicin is due to the depletion of endogenous CGRP.	Capsaicin	237-246	calcitonin-related polypeptide alpha	Rattus norvegicus	285-289
2597077-9	1989	Capsaicin treatment caused a reduction in nerve fibers displaying SP-LI and CGRP-LI.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
2474161-0	1989	ACE-inhibitor-induced enhancement of spontaneous and IgE-mediated histamine release from mast cells and basophilic leukocytes and the modulatory effect of capsaicin sensitive nerves.	Capsaicin	155-164	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	0-3
2474161-2	1989	Intradermally evoked wheal and flare reactions to ovalbumin, capsaicin and bradykinin, in ovalbumin sensitized guinea pigs, was previously demonstrated to be enhanced by pretreatment with the ACE-inhibitor MK 422 (the active parent diacid of enalapril).	Capsaicin	61-70	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	192-195
2492344-7	1989	Exposure of dorsal, but not ventral, spinal cord synaptosomes to capsaicin produced a dose- and Ca++-dependent release of adenosine, which was reduced by capsaicin pretreatment (neonatal and adult) and inhibition of ecto-5"-nucleotidase.	Capsaicin	65-74	5' nucleotidase, ecto	Rattus norvegicus	216-236
2787487-0	1989	Calcitonin gene-related peptide in the rat kidney: occurrence, sensitivity to capsaicin, and stimulation of adenylate cyclase.	Capsaicin	78-87	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
2787487-3	1989	Capsaicin pretreatment significantly reduced CGRP-like immunoreactivity in the medulla and papilla while a small reduction was found in the cortex.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	45-49
2787487-5	1989	Some CGRP-immunoreactive fibres were also seen in kidneys from capsaicin-pretreated rats.	Capsaicin	63-72	calcitonin-related polypeptide alpha	Rattus norvegicus	5-9
2787487-6	1989	Infusion of capsaicin (1 microM) through the renal artery of isolated and perfused rat kidney increased the CGRP-like immunoreactivity outflow from the venous effluent.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	108-112
2787487-15	1989	It is concluded that CGRP contained in capsaicin-sensitive sensory nerve may exert a local function in discrete areas of the rat kidney.	Capsaicin	39-48	calcitonin-related polypeptide alpha	Rattus norvegicus	21-25
2461438-11	1988	The relaxant effect of capsaicin is likely to be induced by release of CGRP rather than SP.	Capsaicin	23-32	calcitonin related polypeptide alpha	Homo sapiens	71-75
2461438-11	1988	The relaxant effect of capsaicin is likely to be induced by release of CGRP rather than SP.	Capsaicin	23-32	tachykinin precursor 1	Homo sapiens	88-90
2699758-2	1989	Substance P and calcitonin gene-related peptide (CGRP) are released from capsaicin-sensitive afferents and are candidates as mediators of plasma protein extravasation and antidromic vasodilatation.	Capsaicin	73-82	tachykinin precursor 1	Homo sapiens	0-11
2699758-2	1989	Substance P and calcitonin gene-related peptide (CGRP) are released from capsaicin-sensitive afferents and are candidates as mediators of plasma protein extravasation and antidromic vasodilatation.	Capsaicin	73-82	calcitonin related polypeptide alpha	Homo sapiens	16-47
2699758-2	1989	Substance P and calcitonin gene-related peptide (CGRP) are released from capsaicin-sensitive afferents and are candidates as mediators of plasma protein extravasation and antidromic vasodilatation.	Capsaicin	73-82	calcitonin related polypeptide alpha	Homo sapiens	49-53
3272159-0	1988	Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin.	Capsaicin	112-121	nerve growth factor	Rattus norvegicus	0-19
2467330-3	1988	A complete depletion of CGRP-LI following capsaicin treatment of both adult and newborn animals was observed in urinary bladder, ureter, atrium, vas deferens and skin.	Capsaicin	42-51	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
2467330-4	1988	Capsaicin pretreatment of both adult and newborn rats reduced CGRP-LI in the duodenum by about 50%.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	62-66
2467330-7	1988	A significant correlation was found between CGRP-LI and SP-LI or TK-LI in tissues where immunoreactivities were depleted by capsaicin, as well as in the urinary bladder of individual animals.	Capsaicin	124-133	calcitonin-related polypeptide alpha	Rattus norvegicus	44-48
2467330-8	1988	The correlation between CGRP-LI with SP-LI and TK-LI upon treatment with capsaicin indicates that neurons containing SP and TK as well as CGRP, and neurons containing CGRP only, are affected in a similar manner by capsaicin.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
2467330-8	1988	The correlation between CGRP-LI with SP-LI and TK-LI upon treatment with capsaicin indicates that neurons containing SP and TK as well as CGRP, and neurons containing CGRP only, are affected in a similar manner by capsaicin.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	138-142
2467330-8	1988	The correlation between CGRP-LI with SP-LI and TK-LI upon treatment with capsaicin indicates that neurons containing SP and TK as well as CGRP, and neurons containing CGRP only, are affected in a similar manner by capsaicin.	Capsaicin	214-223	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
2467330-8	1988	The correlation between CGRP-LI with SP-LI and TK-LI upon treatment with capsaicin indicates that neurons containing SP and TK as well as CGRP, and neurons containing CGRP only, are affected in a similar manner by capsaicin.	Capsaicin	214-223	calcitonin-related polypeptide alpha	Rattus norvegicus	138-142
2467330-8	1988	The correlation between CGRP-LI with SP-LI and TK-LI upon treatment with capsaicin indicates that neurons containing SP and TK as well as CGRP, and neurons containing CGRP only, are affected in a similar manner by capsaicin.	Capsaicin	214-223	calcitonin-related polypeptide alpha	Rattus norvegicus	138-142
2467330-8	1988	The correlation between CGRP-LI with SP-LI and TK-LI upon treatment with capsaicin indicates that neurons containing SP and TK as well as CGRP, and neurons containing CGRP only, are affected in a similar manner by capsaicin.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	138-142
3272159-0	1988	Nerve growth factor (NGF) regulates adult rat cultured dorsal root ganglion neuron responses to the excitotoxin capsaicin.	Capsaicin	112-121	nerve growth factor	Rattus norvegicus	21-24
3272159-4	1988	When cultured with NGF, approximately 50% of these adult DRG neurons were capsaicin-sensitive, whereas adult sympathetic neurons or ganglionic nonneuronal cells were insensitive.	Capsaicin	74-83	nerve growth factor	Rattus norvegicus	19-22
3272159-6	1988	Capsaicin sensitivity could be regained fully within 4-6 days of replacement of NGF.	Capsaicin	0-9	nerve growth factor	Rattus norvegicus	80-83
3272159-7	1988	These results indicate that, at least in vitro, NGF can modify the capsaicin sensitivity of adult DRG neurons.	Capsaicin	67-76	nerve growth factor	Rattus norvegicus	48-51
3143749-10	1988	Following the neonatal administration of capsaicin (50 mg/kg), 1B2/1B7 immunoreactivity was lost from all submucosal neurons; however, VIP immunoreactivity was not depleted from the cell bodies.	Capsaicin	41-50	vasoactive intestinal peptide	Rattus norvegicus	135-138
2851881-2	1988	Because nedocromil has previously been shown to inhibit reflex bronchoconstriction provoked by inhaled sulphur dioxide and inhaled bradykinin, the results suggest that inhaled capsaicin acts on different nerve fibres.	Capsaicin	176-185	kininogen 1	Homo sapiens	131-141
3069183-3	1988	Nerve section with or without ganglionectomy and experiments involving the neonatal administration of capsaicin indicate that the CGRP-immunoreactive fibers in the carotid body come from the glossopharyngeal, vagal and spinal sensory ganglia, although those from the glossopharyngeal ganglion are predominant.	Capsaicin	102-111	calcitonin-related polypeptide alpha	Rattus norvegicus	130-134
3192902-0	1988	Capsaicin pretreatment attenuates multiple responses to cholecystokinin in rats.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	56-71
3266656-6	1988	Capsaicin induced the simultaneous release of CGRP-IR and TK-IR from the guinea-pig ureter while in the rat only the release of CGRP-IR was detectable.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	46-50
3266656-6	1988	Capsaicin induced the simultaneous release of CGRP-IR and TK-IR from the guinea-pig ureter while in the rat only the release of CGRP-IR was detectable.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	128-132
3185968-0	1988	Bradykinin-induced stimulation of afferent fibres is mediated through protein kinase C. In an in vitro preparation of the neonatal spinal cord with the tail attached, brief administration of bradykinin or capsaicin in the tail superfusate containing a normal calcium concentration, activated peripheral fibres and produced a depolarization recorded at a spinal ventral root (L3-L5).	Capsaicin	205-214	kininogen 1	Homo sapiens	0-10
3185968-7	1988	These data suggest that a phorbol ester and bradykinin stimulate capsaicin-sensitive C-fibres by a mechanism which involves the activation of protein kinase C.	Capsaicin	65-74	kininogen 1	Homo sapiens	44-54
3140703-15	1988	The pain-mediating function of SP can be blocked selectively by capsaicin, the pungent component of red pepper, which leads to desensitization of the receptors and degeneration of the afferent C fibers without affecting other sensory qualities.	Capsaicin	64-73	tachykinin precursor 1	Homo sapiens	31-33
3263593-1	1988	Calcitonin gene-related peptide-like immunoreactivity (CGRP-LI) was detected in the rat urinary bladder, ureter and vas deferens and was depleted by systemic capsaicin desensitization.	Capsaicin	158-167	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
3263593-2	1988	Exposure to capsaicin in vitro produced a prompt increase in CGRP-LI outflow in superfusates of these tissues, while a second application of the drug was ineffective indicating desensitization.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	61-65
3263593-3	1988	These findings provide further evidence for a transmitter role of CGRP from peripheral endings of sensory nerves and the involvement of CGRP-LI in the specific motor response to capsaicin in the rat genitourinary tract.	Capsaicin	178-187	calcitonin-related polypeptide alpha	Rattus norvegicus	136-140
3192902-4	1988	Similarly, capsaicin pretreatment markedly attenuated the stimulatory effect of CCK on OT secretion and the inhibitory effect of CCK on gastric emptying in rats.	Capsaicin	11-20	cholecystokinin	Rattus norvegicus	80-83
3192902-4	1988	Similarly, capsaicin pretreatment markedly attenuated the stimulatory effect of CCK on OT secretion and the inhibitory effect of CCK on gastric emptying in rats.	Capsaicin	11-20	cholecystokinin	Rattus norvegicus	129-132
3136661-0	1988	Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats.	Capsaicin	61-70	cholecystokinin	Rattus norvegicus	0-15
3245735-5	1988	After the exposure of the tissue to capsaicin in vitro, the intensity of substance P- and CGRP-like immunofluorescence diminished markedly, while that of neuropeptide Y- and vasoactive intestinal polypeptide-like immunofluorescence was not grossly altered.	Capsaicin	36-45	neuropeptide Y	Felis catus	154-168
3136661-2	1988	The capsaicin treatment significantly attenuated the decrease in intragastric pressure in urethan-anesthetized rats in response to CCK-8 (0.1-100 pmol iv) compared with vehicle-treated controls.	Capsaicin	4-13	cholecystokinin	Rattus norvegicus	131-134
3136661-6	1988	Perivagal capsaicin treatment abolished the delay in gastric emptying induced by CCK-8.	Capsaicin	10-19	cholecystokinin	Rattus norvegicus	81-84
3136661-8	1988	These results demonstrate that CCK-8 decreases gastric motility in the gastric corpus and delays gastric emptying by a capsaicin-sensitive vagal afferent pathway.	Capsaicin	119-128	cholecystokinin	Rattus norvegicus	31-34
2462373-4	1988	A significantly increased outflow of both SP-LI and NKA-LI was observed during perfusion of the lung with high potassium concentration (60 mM), the C-fiber activator capsaicin (1 microM), bradykinin (1 microM), histamine (100 microM), or the nicotinic agonist dimethylphenyl piperazinium (DMPP) (32 microM).	Capsaicin	166-175	tachykinin precursor 1	Homo sapiens	52-55
3067223-5	1988	Neonatal treatment with capsaicin resulted in a drastic reduction of immunoreactivity for SP, PHM, ST14, 1-14 S28, and in a partial reduction of CGRP-like positive perikarya.	Capsaicin	24-33	calcitonin-related polypeptide alpha	Rattus norvegicus	145-149
3171991-10	1988	In capsaicin-treated rats six single and three multi-units were MCh and one multi-unit was classified as an M recording.	Capsaicin	3-12	oleoyl-ACP hydrolase	Rattus norvegicus	64-67
3265787-0	1988	Capsaicin-sensitive structures as potential target sites for neurotensin and bradykinin in guinea pig atria.	Capsaicin	0-9	neurotensin/neuromedin N	Cavia porcellus	61-72
2839796-4	1988	Only beta-CGRP was detected in the intestines of capsaicin-treated rats.	Capsaicin	49-58	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
2841542-0	1988	Quantitative assay of capsaicin-sensitive thiamine monophosphatase and beta-glycerophosphatase activity in rodent spinal cord.	Capsaicin	22-31	acid phosphatase 3	Rattus norvegicus	42-66
2841542-7	1988	After capsaicin (50 mg/kg s.c.) pretreatment, beta-GPase activity in the upper dorsal horn was decreased by 29% in rats and by 17% in mice; TMPase activity was reduced by 48% and 37% respectively.	Capsaicin	6-15	acid phosphatase, prostate	Mus musculus	140-146
2851106-9	1988	Human CGRP alpha and beta mimicked the contractile effects of capsaicin in the guinea-pig atrium.	Capsaicin	62-71	calcitonin-related polypeptide alpha	Rattus norvegicus	6-10
2851106-18	1988	In conclusion the present data provide further evidence that the capsaicin-induced stimulation of atrial contractility is due to local release of CGRP.	Capsaicin	65-74	calcitonin-related polypeptide alpha	Rattus norvegicus	146-150
3420015-0	1988	Capsaicin application to central or peripheral vagal fibers attenuates CCK satiety.	Capsaicin	0-9	cholecystokinin	Homo sapiens	71-74
3420015-2	1988	Intraperitoneal, fourth ventricular or perivagal application of capsaicin attenuated or abolished cholecystokinin (CCK)-induced suppression of food intake.	Capsaicin	64-73	cholecystokinin	Homo sapiens	98-113
3420015-2	1988	Intraperitoneal, fourth ventricular or perivagal application of capsaicin attenuated or abolished cholecystokinin (CCK)-induced suppression of food intake.	Capsaicin	64-73	cholecystokinin	Homo sapiens	115-118
3420015-8	1988	These data indicate that localized capsaicin application attenuates CCK-induced suppression of food intake by impairing the function of either central or peripheral portions of vagal afferent neurons.	Capsaicin	35-44	cholecystokinin	Homo sapiens	68-71
3420015-9	1988	The data also support the conclusion that intraperitoneal capsaicin attenuates CCK-induced suppression of feeding by impairing vagal sensory function.	Capsaicin	58-67	cholecystokinin	Homo sapiens	79-82
3266056-5	1988	The tissue content of CGRP-LI was markedly reduced by systemic pretreatment with capsaicin, suggesting a sensory origin.	Capsaicin	81-90	calcitonin-related polypeptide alpha	Rattus norvegicus	22-26
2452458-0	1988	Calcitonin gene-related peptide and the lung: neuronal coexistence with substance P, release by capsaicin and vasodilatory effect.	Capsaicin	96-105	calcitonin related polypeptide alpha	Homo sapiens	0-31
2452458-4	1988	Systemic capsaicin pretreatment induced a marked loss of the CGRP- and SP-immunoreactive (-IR) nerves in the lower airways.	Capsaicin	9-18	calcitonin related polypeptide alpha	Homo sapiens	61-65
2452458-6	1988	The content of CGRP-LI as measured with RIA in guinea pig bronchi was significantly lower after capsaicin pretreatment.	Capsaicin	96-105	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
2452458-8	1988	In the isolated perfused guinea pig lung capsaicin exposure caused overflow of CGRP-LI suggesting release from peripheral branches of sensory nerves.	Capsaicin	41-50	calcitonin-related polypeptide alpha	Rattus norvegicus	79-83
2452458-11	1988	In conclusion, the presence and release of CGRP-LI from capsaicin sensitive nerves in the lower airways adds another possible mediator, in addition to tachykinins, of vascular reactions upon sensory nerve irritation.	Capsaicin	56-65	calcitonin-related polypeptide alpha	Rattus norvegicus	43-47
3261927-7	1988	In the epididymis of young rats treated neonatally with capsaicin, CGRP-immunoreactive nerve fibers were almost completely absent.	Capsaicin	56-65	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
2466391-4	1988	In this thesis the ACE-inhibitor MK 422 (active parent diacid of enalapril) was demonstrated to potentiate wheal and flare reactions induced by allergens, bradykinin or capsaicin, and to increase infiltration of "inflammatory cells", like eosinophils and neutrophils, into inflammatory dermal test sites in sensitized guinea pigs.	Capsaicin	169-178	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	19-22
2466391-6	1988	Capsaicin "desensitization" of guinea pig skin markedly reduced the wheal and flare reactions to allergens and attenuated the proinflammatory effect of the ACE-inhibitor.	Capsaicin	0-9	LOW QUALITY PROTEIN: angiotensin-converting enzyme	Cavia porcellus	156-159
3266056-6	1988	Activation of capsaicin-sensitive cardiac C-fibres by K+, nicotine, bradykinin, ouabain and ischaemia was associated with a release of CGRP as indicated by an increased overflow from the isolated perfused guinea-pig heart.	Capsaicin	14-23	calcitonin-related polypeptide alpha	Rattus norvegicus	135-139
3266056-15	1988	The stimulatory actions of capsaicin on atrial contractility therefore seem to be evoked by CGRP.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	92-96
2446887-0	1987	Calcitonin gene-related peptide but not substance P mimics capsaicin-induced coronary vasodilation in the pig.	Capsaicin	59-68	Calcitonin gene-related peptide	Sus scrofa	0-31
2457537-16	1988	In preparations desensitized to exogenous CGRP, the inhibitory effect of capsaicin was almost abolished.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
3501848-0	1987	Co-localization of tachykinins and calcitonin gene-related peptide in capsaicin-sensitive afferents in relation to motility effects on the human ureter in vitro.	Capsaicin	70-79	calcitonin related polypeptide alpha	Homo sapiens	35-66
3501848-4	1987	Capsaicin treatment caused an almost total disappearance of both neurokinin A-, substance P- and CGRP-immunoreactive nerve fibres in the guinea-pig ureter and a 90% depletion of neurokinin A, substance P- and CGRP-like immunoreactivity, further supporting a sensory origin of these nerves.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	65-77
3501848-4	1987	Capsaicin treatment caused an almost total disappearance of both neurokinin A-, substance P- and CGRP-immunoreactive nerve fibres in the guinea-pig ureter and a 90% depletion of neurokinin A, substance P- and CGRP-like immunoreactivity, further supporting a sensory origin of these nerves.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	80-91
3501848-4	1987	Capsaicin treatment caused an almost total disappearance of both neurokinin A-, substance P- and CGRP-immunoreactive nerve fibres in the guinea-pig ureter and a 90% depletion of neurokinin A, substance P- and CGRP-like immunoreactivity, further supporting a sensory origin of these nerves.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	97-101
3501848-4	1987	Capsaicin treatment caused an almost total disappearance of both neurokinin A-, substance P- and CGRP-immunoreactive nerve fibres in the guinea-pig ureter and a 90% depletion of neurokinin A, substance P- and CGRP-like immunoreactivity, further supporting a sensory origin of these nerves.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	178-190
3501848-4	1987	Capsaicin treatment caused an almost total disappearance of both neurokinin A-, substance P- and CGRP-immunoreactive nerve fibres in the guinea-pig ureter and a 90% depletion of neurokinin A, substance P- and CGRP-like immunoreactivity, further supporting a sensory origin of these nerves.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	192-203
3501848-4	1987	Capsaicin treatment caused an almost total disappearance of both neurokinin A-, substance P- and CGRP-immunoreactive nerve fibres in the guinea-pig ureter and a 90% depletion of neurokinin A, substance P- and CGRP-like immunoreactivity, further supporting a sensory origin of these nerves.	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	209-213
3263538-5	1988	Tachykinins and CGRP are released from these sensory nerves upon acute chemical irritation by, for instance, capsaicin.	Capsaicin	109-118	calcitonin-related polypeptide alpha	Rattus norvegicus	16-20
3263538-7	1988	After pretreatment with high doses of capsaicin, tachykinins and CGRP are depleted from the sensory nerves which subsequently degenerate.	Capsaicin	38-47	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
2980286-6	1988	Pretreatment of adult guinea-pigs with capsaicin (50 mg kg-1 s.c.) produced a long-lasting (greater than or equal to 10 weeks) depletion of substance P- and calcitonin gene related peptide-like immunoreactivities in the sensory nerves of the larynx, tracheobronchial tree and lung.	Capsaicin	39-48	calcitonin	Cavia porcellus	140-167
2826187-0	1987	Visceromotor responses to calcitonin gene-related peptide (CGRP) in the rat lower urinary tract: evidence for a transmitter role in the capsaicin-sensitive nerves of the ureter.	Capsaicin	136-145	calcitonin-related polypeptide alpha	Rattus norvegicus	26-57
2826187-0	1987	Visceromotor responses to calcitonin gene-related peptide (CGRP) in the rat lower urinary tract: evidence for a transmitter role in the capsaicin-sensitive nerves of the ureter.	Capsaicin	136-145	calcitonin-related polypeptide alpha	Rattus norvegicus	59-63
2826187-7	1987	Lack of desensitization to the action of CGRP prevented the study of its interaction with capsaicin.	Capsaicin	90-99	calcitonin-related polypeptide alpha	Rattus norvegicus	41-45
2826187-8	1987	The inhibitory effect of CGRP in the ureter exhibited a specific desensitization: if the preparations were pre-exposed to exogenous CGRP, the inhibition of motility produced by antidromic activation of the capsaicin-sensitive nerve terminals (field stimulation) as well as the response to capsaicin (1 microM) was prevented but the inhibitory response to isoprenaline was unaffected.	Capsaicin	206-215	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
2826187-8	1987	The inhibitory effect of CGRP in the ureter exhibited a specific desensitization: if the preparations were pre-exposed to exogenous CGRP, the inhibition of motility produced by antidromic activation of the capsaicin-sensitive nerve terminals (field stimulation) as well as the response to capsaicin (1 microM) was prevented but the inhibitory response to isoprenaline was unaffected.	Capsaicin	206-215	calcitonin-related polypeptide alpha	Rattus norvegicus	132-136
2826187-8	1987	The inhibitory effect of CGRP in the ureter exhibited a specific desensitization: if the preparations were pre-exposed to exogenous CGRP, the inhibition of motility produced by antidromic activation of the capsaicin-sensitive nerve terminals (field stimulation) as well as the response to capsaicin (1 microM) was prevented but the inhibitory response to isoprenaline was unaffected.	Capsaicin	289-298	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
2826187-8	1987	The inhibitory effect of CGRP in the ureter exhibited a specific desensitization: if the preparations were pre-exposed to exogenous CGRP, the inhibition of motility produced by antidromic activation of the capsaicin-sensitive nerve terminals (field stimulation) as well as the response to capsaicin (1 microM) was prevented but the inhibitory response to isoprenaline was unaffected.	Capsaicin	289-298	calcitonin-related polypeptide alpha	Rattus norvegicus	132-136
2826187-10	1987	Endogenous CGRP could be the inhibitory transmitter which, when released from capsaicin-sensitive fibers, participate in the control of ureteral motility.	Capsaicin	78-87	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
2445958-7	1987	The content of substance P (SP) in the ocular anterior segments was decreased, dose-dependently, with capsaicin administration.	Capsaicin	102-111	tachykinin 1	Mus musculus	15-26
2445958-7	1987	The content of substance P (SP) in the ocular anterior segments was decreased, dose-dependently, with capsaicin administration.	Capsaicin	102-111	tachykinin 1	Mus musculus	28-30
2445958-8	1987	Neonatal administration of 6-OHDA decreased the rate of capsaicin-induced reduction of SP.	Capsaicin	56-65	tachykinin 1	Mus musculus	87-89
2445958-9	1987	However, this effect of 6-OHDA was too slight to explain the suppression of the corneal lesions, as the intensity score of lesions with a large dose of capsaicin after 6-OHDA was lower than that with a small dose of capsaicin without 6-OHDA, whereas SP content in the former was still much lower than that in the latter.	Capsaicin	152-161	tachykinin 1	Mus musculus	250-252
2450340-0	1987	Participation of capsaicin-sensitive neurons in the cardiovascular effects of neurotensin in guinea pigs.	Capsaicin	17-26	neurotensin/neuromedin N	Cavia porcellus	78-89
2450340-5	1987	The positive inotropic and chronotropic effects of NT in guinea pig atria were mimicked by capsaicin and calcitonin gene-related peptide (CGRP).	Capsaicin	91-100	neurotensin/neuromedin N	Cavia porcellus	51-53
2450340-6	1987	These results were interpreted as an indication that NT produces its cardiovascular effects in guinea pigs by activating capsaicin-sensitive sensory neurons.	Capsaicin	121-130	neurotensin/neuromedin N	Cavia porcellus	53-55
3118870-0	1987	Inhibition of calcium and calmodulin-dependent phosphodiesterase activity in rats by capsaicin.	Capsaicin	85-94	calmodulin 1	Rattus norvegicus	26-36
3118870-1	1987	Capsaicin, reported to elevate hormone sensitive lipase (HSL), is also found to inhibit the Ca++ and calmodulin-dependent cAMP phosphodiesterase (PDE) activity in adipose tissue of rats, fed high fat diet.	Capsaicin	0-9	lipase E, hormone sensitive type	Rattus norvegicus	31-55
3118870-1	1987	Capsaicin, reported to elevate hormone sensitive lipase (HSL), is also found to inhibit the Ca++ and calmodulin-dependent cAMP phosphodiesterase (PDE) activity in adipose tissue of rats, fed high fat diet.	Capsaicin	0-9	lipase E, hormone sensitive type	Rattus norvegicus	57-60
3118870-1	1987	Capsaicin, reported to elevate hormone sensitive lipase (HSL), is also found to inhibit the Ca++ and calmodulin-dependent cAMP phosphodiesterase (PDE) activity in adipose tissue of rats, fed high fat diet.	Capsaicin	0-9	calmodulin 1	Rattus norvegicus	101-111
3118870-5	1987	Enzyme inhibition in vivo, due to capsaicin, was overcome by addition of calmodulin to the assay system.	Capsaicin	34-43	calmodulin 1	Rattus norvegicus	73-83
3118870-6	1987	Inclusion of fluphenazine or capsaicin in assay inhibited not only the calmodulin-restored enzyme activity from test rats but also that of control rats.	Capsaicin	29-38	calmodulin 1	Rattus norvegicus	71-81
2446887-10	1987	The capsaicin-induced coronary vasodilation is therefore more likely to depend on release of CGRP rather than tachykinins from sensory nerves since neither endothelium removal nor SP-tachyphylaxis influenced the capsaicin and CGRP responses.	Capsaicin	4-13	Calcitonin gene-related peptide	Sus scrofa	93-97
3429461-0	1987	Capsaicin-induced inhibition of motility of the rat isolated vas deferens: do multiple neuropeptides mediate the visceromotor effects of capsaicin?	Capsaicin	0-9	arginine vasopressin	Rattus norvegicus	61-64
3497262-2	1987	Capsaicin attenuated the twitch response of the rat vas deferens induced by the transmural nerve stimulation (TNS) in vitro.	Capsaicin	0-9	arginine vasopressin	Rattus norvegicus	52-55
3497262-8	1987	The intensity of CGRP-like immunoreactivity was reduced markedly after the in vitro incubation of the tissue with capsaicin.	Capsaicin	114-123	calcitonin-related polypeptide alpha	Rattus norvegicus	17-21
3497262-10	1987	Thus, capsaicin inhibited both the TNS-induced twitch response and the contraction induced by direct stimulation of the smooth muscles only when CGRP-like immunoreactive nerves were normally present.	Capsaicin	6-15	calcitonin-related polypeptide alpha	Rattus norvegicus	145-149
3497262-11	1987	These results suggest that capsaicin releases endogenous CGRP and that the released CGRP inhibits the contraction of the rat vas deferens by acting directly on smooth muscle cells but not on the sympathetic nerves.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	57-61
3497262-11	1987	These results suggest that capsaicin releases endogenous CGRP and that the released CGRP inhibits the contraction of the rat vas deferens by acting directly on smooth muscle cells but not on the sympathetic nerves.	Capsaicin	27-36	arginine vasopressin	Rattus norvegicus	125-128
3039423-0	1987	Immunoblockade of response to capsaicin in the rat vas deferens: evidence for the involvement of endogenous calcitonin gene-related peptide.	Capsaicin	30-39	arginine vasopressin	Rattus norvegicus	51-54
3039423-1	1987	In the rat isolated vas deferens, capsaicin induced a transitory inhibition of the nerve-mediated contractions.	Capsaicin	34-43	arginine vasopressin	Rattus norvegicus	20-23
3039423-4	1987	A highly avid and specific anti-CGRP serum raised in rabbits against conjugated synthetic rat CGRP inhibited selectively the capsaicin effect.	Capsaicin	125-134	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
3039423-4	1987	A highly avid and specific anti-CGRP serum raised in rabbits against conjugated synthetic rat CGRP inhibited selectively the capsaicin effect.	Capsaicin	125-134	calcitonin-related polypeptide alpha	Rattus norvegicus	94-98
3039423-5	1987	These findings are consistent with the hypothesis that, in this preparation, the specific visceromotor response to capsaicin is brought about by the release of endogenous CGRP from sensory nerves.	Capsaicin	115-124	calcitonin-related polypeptide alpha	Rattus norvegicus	171-175
3611458-5	1987	In an attempt to alleviate the pain of 14 patients with postherpetic neuralgia, capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), known to deplete substance P, was applied topically to painful areas of skin for 4 weeks.	Capsaicin	80-89	tachykinin precursor 1	Homo sapiens	149-160
3611458-5	1987	In an attempt to alleviate the pain of 14 patients with postherpetic neuralgia, capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), known to deplete substance P, was applied topically to painful areas of skin for 4 weeks.	Capsaicin	91-129	tachykinin precursor 1	Homo sapiens	149-160
2951622-1	1987	Capsaicin, a neurotoxic agent that induces a decrease in hypothalamic beta-endorphin, a specific antiserum and human beta-endorphin fragment 6 31, a peptidergic beta-endorphin antagonist have been used in the attempt of selectively affecting the function of beta-endorphinergic system and of evaluating the possible role of this peptide in the analgesic effect of morphine.	Capsaicin	0-9	proopiomelanocortin	Homo sapiens	70-84
3469455-5	1987	TPA (10 and 100 nM) decreased the ODC activity of cells, and capsaicin (100 microM) induced ODC by 220%.	Capsaicin	61-70	ornithine decarboxylase 1	Homo sapiens	92-95
2438668-0	1987	Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.	Capsaicin	42-51	calcitonin related polypeptide alpha	Homo sapiens	33-37
2438668-0	1987	Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.	Capsaicin	42-51	tachykinin precursor 1	Homo sapiens	62-73
2438668-0	1987	Calcitonin gene-related peptide (CGRP) in capsaicin-sensitive substance P-immunoreactive sensory neurons in animals and man: distribution and release by capsaicin.	Capsaicin	153-162	calcitonin related polypeptide alpha	Homo sapiens	33-37
2438668-9	1987	Systemic capsaicin pretreatment and adult guinea-pigs caused a loss of CGRP-IR terminals in the dorsal horn of the spinal cord as well as in peripheral organs including the heart.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	71-75
2438668-10	1987	After capsaicin treatment, the content of CGRP-IR was reduced by 70% in the heart and by 60% in the dorsal part of the spinal cord.	Capsaicin	6-15	calcitonin-related polypeptide alpha	Rattus norvegicus	42-46
2438668-11	1987	In superfusion experiments with slices from the rat spinal cord, a release of CGRP-LI was induced by 60 mM K+ and 3 microM capsaicin in a calcium-dependent manner.	Capsaicin	123-132	calcitonin-related polypeptide alpha	Rattus norvegicus	78-82
2444068-5	1987	The capsaicin-induced nociceptive reflex was depressed by application to the spinal cord of morphine, Met-enkephalin, dynorphin (1-13), somatostatin, adenosine, GABA and a substance P (SP) antagonist [D-Arg1, D-Pro2, D-Trp7,9, Leu11]SP, and potentiated by bicuculline.	Capsaicin	4-13	arginase 1	Rattus norvegicus	203-207
3490633-10	1986	Neonatal pretreatment with capsaicin caused a marked reduction in CGRP immunoreactivity of nerve fibres in the respiratory tracts as well as a less marked decrease in the population of CGRP-containing endocrine cells of the lung.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	66-70
3490633-10	1986	Neonatal pretreatment with capsaicin caused a marked reduction in CGRP immunoreactivity of nerve fibres in the respiratory tracts as well as a less marked decrease in the population of CGRP-containing endocrine cells of the lung.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	185-189
3491329-0	1986	Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons.	Capsaicin	143-152	calcitonin-related polypeptide alpha	Rattus norvegicus	97-128
3491329-0	1986	Extrinsic origin of the capsaicin-sensitive innervation of rat duodenum: possible involvement of calcitonin gene-related peptide (CGRP) in the capsaicin-induced activation of intramural non-adrenergic non-cholinergic neurons.	Capsaicin	143-152	calcitonin-related polypeptide alpha	Rattus norvegicus	130-134
2428442-8	1986	Furthermore, a putative SP antagonist ([D-Arg1, D-Pro2, D-Tryp7,9, Leu11]-SP) prevented the augmented capsaicin ventral root response during precipitated withdrawal.	Capsaicin	102-111	arginase 1	Rattus norvegicus	42-46
2442444-8	1987	KCl and capsaicin also produced a tachykininergic contraction which was inhibited by [D-Arg1, D-Pro2, D-Trp7,9, Leu11]-SP.	Capsaicin	8-17	arginase-1	Oryctolagus cuniculus	88-92
2442444-10	1987	These results suggest that the tachykininergic responses induced by electrical transmural stimulation, KCl and capsaicin are predominantly mediated by neurokinin A, probably released from the peripheral endings of trigeminal nerves.	Capsaicin	111-120	tachykinin precursor 1	Homo sapiens	151-163
2435372-2	1987	Calcitonin gene-related peptide (CGRP: 10(-6) M) significantly potentiated the capsaicin-induced release of iSP.	Capsaicin	79-88	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
3310523-2	1987	The best studied peptide is substance P, which has been localized in a population of capsaicin-sensitive visceral afferents.	Capsaicin	85-94	tachykinin precursor 1	Homo sapiens	28-39
3310523-6	1987	Substance P has been localized in these laminae and appears to be capsaicin-sensitive and therefore of sensory origin.	Capsaicin	66-75	tachykinin precursor 1	Homo sapiens	0-11
3499054-9	1987	The material released upon stimulation with capsaicin was further characterized by HPLC, and the main peak of the immunoreactivity co-eluted with ELE, a smaller peak eluted in the position of NKA, but no clear evidence for the release of material co-eluting with NPK was observed.	Capsaicin	44-53	tachykinin precursor 1	Homo sapiens	192-195
3501146-11	1987	Neonatal capsaicin treatment greatly attenuated the immunostaining, providing evidence for CGRP-LI localization in chemosensitive unmyelinated afferents.	Capsaicin	9-18	calcitonin-related polypeptide alpha	Rattus norvegicus	91-95
3429461-9	1987	Capsaicin inhibition exhibited a marked desensitization while the effect of CGRP was still evident after capsaicin-desensitization.	Capsaicin	105-114	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
3429461-10	1987	5 The inhibitory effect of capsaicin or CGRP on the Kassinin-stimulated rhythmic contractions of the rat isolated vas deferens was unaffected by a previous exposure to tetrodotoxin (0.5 microM).	Capsaicin	27-36	arginine vasopressin	Rattus norvegicus	114-117
3429461-14	1987	7 These findings indicate the existence, in the rat isolated vas deferens, of capsaicin-sensitive sensory innervation which, upon chemical stimulation, releases, through a tetrodotoxin-insensitive mechanism, a substance(s) which inhibits motility at postjunctional level.	Capsaicin	78-87	arginine vasopressin	Rattus norvegicus	61-64
3429461-15	1987	CGRP is a possible candidate for the role of inhibitory sensory transmitter released from capsaicin-sensitive nerve endings in this preparation.	Capsaicin	90-99	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2427561-8	1986	However, the loss of rat CGRP-immunoreactive nerves was dose-dependent and displayed considerable variation, some perivascular nerve networks appearing less susceptible than others to the action of capsaicin.	Capsaicin	198-207	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
3491329-9	1986	Either ATP- or CGRP-desensitization reduced (about 50 and 65% respectively) the amplitude of the capsaicin-induced relaxations.	Capsaicin	97-106	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
2427561-9	1986	The results suggest that there may be species differences in the sensitivity of CGRP-containing nerves to capsaicin treatment, but at least the majority of CGRP-immunoreactive cardiovascular nerves may be presumed to be sensory in origin.	Capsaicin	106-115	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
2427561-6	1986	Following capsaicin treatment of adult guinea pigs and neonatal rats, there was a significant loss of CGRP-immunoreactive nerves in the two species.	Capsaicin	10-19	calcitonin-related polypeptide alpha	Rattus norvegicus	102-106
3490562-6	1986	Pretreatment of the animal with capsaicin abolished CGRP-I nerves of cerebral arteries.	Capsaicin	32-41	calcitonin-related polypeptide alpha	Rattus norvegicus	52-58
2873987-1	1986	Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the active principle of capsicum fruits, such as hot peppers, is a known inhibitor of substance P.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	138-149
2873987-1	1986	Capsaicin (trans-8-methyl-N-vanillyl-6-nonenamide), the active principle of capsicum fruits, such as hot peppers, is a known inhibitor of substance P.	Capsaicin	11-49	tachykinin precursor 1	Homo sapiens	138-149
2873987-6	1986	Our results indicate that the substance P inhibitor, capsaicin, is also an inhibitor of epidermal BP metabolism and DNA binding of its metabolites.	Capsaicin	53-62	tachykinin precursor 1	Homo sapiens	30-41
3013594-10	1986	The results indicate that the cardiac effects of capsaicin may be due to the release of endogenous CGRP through a local mode of action.	Capsaicin	49-58	calcitonin-related polypeptide alpha	Rattus norvegicus	99-103
2426633-5	1986	Arginine vasopressin-like immunoreactivity was present also in laminae I and II of the dorsal horn of the spinal cord and this reactivity was absent in animals which had been treated neonatally with capsaicin, suggesting that it was contained in primary afferent terminals.	Capsaicin	199-208	arginine vasopressin	Rattus norvegicus	9-20
3763436-0	1986	Cholecystokinin-induced suppression of locomotion is attenuated in capsaicin pretreated rats.	Capsaicin	67-76	cholecystokinin	Rattus norvegicus	0-15
3763436-3	1986	Pretreatment of adult rats with capsaicin attenuates the reduced locomotor activity and reduced food intake which normally occurs following injection of exogenous cholecystokinin.	Capsaicin	32-41	cholecystokinin	Rattus norvegicus	163-178
3763436-4	1986	Since capsaicin damages or destroys small-diameter, unmyelinated, sensory neurons, including vagal sensory fibers, these data support the interpretation that both CCK-induced suppression of food intake and CCK-induced reduction of locomotion are mediated by fine, unmyelinated sensory neurons.	Capsaicin	6-15	cholecystokinin	Rattus norvegicus	163-166
3763436-4	1986	Since capsaicin damages or destroys small-diameter, unmyelinated, sensory neurons, including vagal sensory fibers, these data support the interpretation that both CCK-induced suppression of food intake and CCK-induced reduction of locomotion are mediated by fine, unmyelinated sensory neurons.	Capsaicin	6-15	cholecystokinin	Rattus norvegicus	206-209
3087304-3	1986	The hypothermia produced by CAP and NVA was prevented by a small dose of thyrotropin-releasing hormone (TRH) (0.25 nmol/animal) which by itself had little effect on body temperature.	Capsaicin	28-31	thyrotropin releasing hormone	Mus musculus	73-102
3087304-3	1986	The hypothermia produced by CAP and NVA was prevented by a small dose of thyrotropin-releasing hormone (TRH) (0.25 nmol/animal) which by itself had little effect on body temperature.	Capsaicin	28-31	thyrotropin releasing hormone	Mus musculus	104-107
3512035-8	1986	Following systemic treatment with capsaicin, a loss of intra- and subepithelial CGRP-immunoreactive nerves was observed in all investigated tissues, while immunoreactive motor end plates remained unchanged.	Capsaicin	34-43	calcitonin-related polypeptide alpha	Rattus norvegicus	80-84
2878909-4	1986	Conversely, after capsaicin treatment, an increase of TH-immunoreactive nerves was found in the same tissues, concomitant with a sharp decrease of CGRP-immunoreactive nerves.	Capsaicin	18-27	tyrosine hydroxylase	Homo sapiens	54-56
3011997-2	1986	Capsaicin treatment of neonatal mice, which causes a loss of unmyelinated sensory neurons, some of which contain substance P, reduced the mortality rate of HSV-infected mice.	Capsaicin	0-9	tachykinin 1	Mus musculus	113-124
2419807-1	1986	Superfusion of slices of the dorsal half of rat spinal cord in vitro with 10 microM capsaicin or 60 mM potassium lead to the simultaneous release of substance P (SP)-, neurokinin A (NKA)- and calcitonin gene-related peptide (CGRP)-like immunoreactivities (LI).	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	192-223
2419807-1	1986	Superfusion of slices of the dorsal half of rat spinal cord in vitro with 10 microM capsaicin or 60 mM potassium lead to the simultaneous release of substance P (SP)-, neurokinin A (NKA)- and calcitonin gene-related peptide (CGRP)-like immunoreactivities (LI).	Capsaicin	84-93	calcitonin-related polypeptide alpha	Rattus norvegicus	225-229
2419807-2	1986	The ratio between capsaicin-stimulated and basal release was higher for CGRP-LI than for SP-LI, indicating that relatively more CGRP is released from sensory nerves, whereas SP is not only released from afferent neurons.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	72-76
2419807-2	1986	The ratio between capsaicin-stimulated and basal release was higher for CGRP-LI than for SP-LI, indicating that relatively more CGRP is released from sensory nerves, whereas SP is not only released from afferent neurons.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	128-132
3513052-1	1986	Conscious, adult, water-deprived Brattleboro rats treated neonatally with capsaicin or vehicle showed similar hypotensive responses to sequential inhibition of the renin-angiotensin system (with captopril) and antagonism of ganglionic transmission (with pentolinium).	Capsaicin	74-83	renin	Rattus norvegicus	164-169
3513052-3	1986	Furthermore, following administration of captopril and pentolinium, the capsaicin-treated animals showed marked impairment of the vasopressin-dependent recovery of blood pressure.	Capsaicin	72-81	arginine vasopressin	Rattus norvegicus	130-141
3513052-5	1986	Long-Evans rats treated neonatally with capsaicin may be due to less effective compensation for inhibition of the renin-angiotensin system when vasopressin release is impaired.	Capsaicin	40-49	renin	Rattus norvegicus	114-119
3513052-5	1986	Long-Evans rats treated neonatally with capsaicin may be due to less effective compensation for inhibition of the renin-angiotensin system when vasopressin release is impaired.	Capsaicin	40-49	arginine vasopressin	Rattus norvegicus	144-155
2431572-1	1986	Topical application of capsaicin is thought to deplete substance P from local sensory nerve terminals.	Capsaicin	23-32	tachykinin precursor 1	Homo sapiens	55-66
2431572-3	1986	The flare response to SP and histamine was suppressed by capsaicin pretreatment whereas the wheal was enlarged.	Capsaicin	57-66	tachykinin precursor 1	Homo sapiens	22-24
2430427-16	1986	Capsaicin caused an acute release of SP-, NKA- and ELE-like components from superfused slices of both the spinal cord and ureter of the guinea-pig in vitro.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	42-45
2878909-4	1986	Conversely, after capsaicin treatment, an increase of TH-immunoreactive nerves was found in the same tissues, concomitant with a sharp decrease of CGRP-immunoreactive nerves.	Capsaicin	18-27	calcitonin related polypeptide alpha	Homo sapiens	147-151
3529051-4	1986	Capsaicin treatment induced a loss of VIP/PHI from the dorsal horn.	Capsaicin	0-9	vasoactive intestinal peptide	Rattus norvegicus	38-41
2423358-1	1986	Peripheral nerve section or local capsaicin application produces depletion of substance P and an enzymatic marker, fluoride-resistant acid phosphatase (FRAP), from circumscribed regions of the terminal areas in the spinal cord.	Capsaicin	34-43	acid phosphatase 3	Rattus norvegicus	115-150
2423358-1	1986	Peripheral nerve section or local capsaicin application produces depletion of substance P and an enzymatic marker, fluoride-resistant acid phosphatase (FRAP), from circumscribed regions of the terminal areas in the spinal cord.	Capsaicin	34-43	acid phosphatase 3	Rattus norvegicus	152-156
2427561-0	1986	Capsaicin induces a depletion of calcitonin gene-related peptide (CGRP)-immunoreactive nerves in the cardiovascular system of the guinea pig and rat.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	66-70
3529051-4	1986	Capsaicin treatment induced a loss of VIP/PHI from the dorsal horn.	Capsaicin	0-9	glucose-6-phosphate isomerase	Rattus norvegicus	42-45
2417202-6	1985	CGRP-immunoreactivity was depleted by neonatal treatment with capsaicin and after surgical section of pelvic and/or hypogastric nerves.	Capsaicin	62-71	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
2428085-6	1986	Moreover, capsaicin, a primary afferent neurotoxin, depleted sP IR and CCK IR only from the intact side.	Capsaicin	10-19	cholecystokinin	Homo sapiens	71-74
3878946-3	1985	The response to CGRP mimicked the effects of capsaicin and was resistant to beta-adrenoceptor blockade using metoprolol.	Capsaicin	45-54	calcitonin-related polypeptide alpha	Rattus norvegicus	16-20
3878946-6	1985	After tachyphylaxis to the effects of CGRP (5 X 10(-7) M) which developed within 15-20 min, the positive inotropic and chronotropic atrial response to capsaicin was abolished.	Capsaicin	151-160	calcitonin-related polypeptide alpha	Rattus norvegicus	38-42
3878946-9	1985	The CGRP response was resistant to metoprolol and still present in capsaicin-pretreated animals.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	4-8
3878946-11	1985	As for CGRP, the cardioexcitatory response to capsaicin was more pronounced on rate than on force.	Capsaicin	46-55	calcitonin-related polypeptide alpha	Rattus norvegicus	7-11
3878946-13	1985	In conclusion, CGRP mimics the non-adrenergic, cardioexcitatory effects of capsaicin, and the capsaicin response is absent after CGRP tachyphylaxis.	Capsaicin	75-84	calcitonin-related polypeptide alpha	Rattus norvegicus	15-19
3899238-4	1985	During angiotensin converting enzyme inhibition (with captopril) and ganglion blockade (with pentolinium), the vasopressin-mediated blood pressure recovery was more gradual in the capsaicin-treated animals than in the controls, but after 60 min blood pressures were similar in all groups.	Capsaicin	180-189	arginine vasopressin	Rattus norvegicus	111-122
3899238-5	1985	Collectively the results indicate that although the full development of vasopressin-dependent mechanisms following acute hypotension takes longer when a large proportion of unmyelinated afferent fibres have been destroyed by neonatal treatment with capsaicin, 48 h of water deprivation results in a normal involvement of vasopressin-dependent mechanisms in the maintenance of blood pressure.	Capsaicin	249-258	arginine vasopressin	Rattus norvegicus	72-83
3899238-5	1985	Collectively the results indicate that although the full development of vasopressin-dependent mechanisms following acute hypotension takes longer when a large proportion of unmyelinated afferent fibres have been destroyed by neonatal treatment with capsaicin, 48 h of water deprivation results in a normal involvement of vasopressin-dependent mechanisms in the maintenance of blood pressure.	Capsaicin	249-258	arginine vasopressin	Rattus norvegicus	321-332
2413505-0	1985	Abrogation of peripheral cholecystokinin-satiety in the capsaicin treated rat.	Capsaicin	56-65	cholecystokinin	Rattus norvegicus	25-40
2409169-3	1985	Using the skin, eye, and respiratory tract as experimental models, it has been shown that: 1) SP is widely distributed in primary sensory neurons as well as in afferent sensory fibers in the vagus, 2) SP is released from sensory nerve terminals during antidromic stimulation, 3) local administration of SP mimics the effect of sensory nerve stimulation, and 4) hyperemia, plasma leakage, and smooth muscle contractions, normally induced by nerve stimulation or noxious stimuli, are absent in tissues pretreated with the SP depleting agent capsaicin or with SP antagonists.	Capsaicin	539-548	tachykinin precursor 1	Homo sapiens	94-96
2409169-3	1985	Using the skin, eye, and respiratory tract as experimental models, it has been shown that: 1) SP is widely distributed in primary sensory neurons as well as in afferent sensory fibers in the vagus, 2) SP is released from sensory nerve terminals during antidromic stimulation, 3) local administration of SP mimics the effect of sensory nerve stimulation, and 4) hyperemia, plasma leakage, and smooth muscle contractions, normally induced by nerve stimulation or noxious stimuli, are absent in tissues pretreated with the SP depleting agent capsaicin or with SP antagonists.	Capsaicin	539-548	tachykinin precursor 1	Homo sapiens	201-203
2409169-3	1985	Using the skin, eye, and respiratory tract as experimental models, it has been shown that: 1) SP is widely distributed in primary sensory neurons as well as in afferent sensory fibers in the vagus, 2) SP is released from sensory nerve terminals during antidromic stimulation, 3) local administration of SP mimics the effect of sensory nerve stimulation, and 4) hyperemia, plasma leakage, and smooth muscle contractions, normally induced by nerve stimulation or noxious stimuli, are absent in tissues pretreated with the SP depleting agent capsaicin or with SP antagonists.	Capsaicin	539-548	tachykinin precursor 1	Homo sapiens	201-203
2409169-3	1985	Using the skin, eye, and respiratory tract as experimental models, it has been shown that: 1) SP is widely distributed in primary sensory neurons as well as in afferent sensory fibers in the vagus, 2) SP is released from sensory nerve terminals during antidromic stimulation, 3) local administration of SP mimics the effect of sensory nerve stimulation, and 4) hyperemia, plasma leakage, and smooth muscle contractions, normally induced by nerve stimulation or noxious stimuli, are absent in tissues pretreated with the SP depleting agent capsaicin or with SP antagonists.	Capsaicin	539-548	tachykinin precursor 1	Homo sapiens	201-203
2409169-3	1985	Using the skin, eye, and respiratory tract as experimental models, it has been shown that: 1) SP is widely distributed in primary sensory neurons as well as in afferent sensory fibers in the vagus, 2) SP is released from sensory nerve terminals during antidromic stimulation, 3) local administration of SP mimics the effect of sensory nerve stimulation, and 4) hyperemia, plasma leakage, and smooth muscle contractions, normally induced by nerve stimulation or noxious stimuli, are absent in tissues pretreated with the SP depleting agent capsaicin or with SP antagonists.	Capsaicin	539-548	tachykinin precursor 1	Homo sapiens	201-203
2413505-4	1985	These studies were designed to determine the effects on rat feeding behavior, and in particular CCK-satiety, of the sensory neurotoxin capsaicin.	Capsaicin	135-144	cholecystokinin	Rattus norvegicus	96-99
2413505-10	1985	In capsaicin denervated animals, CCK also significantly reduced 30 min food intake from 5.09 +/- 1.10 to 3.92 +/- 0.84 g (P less than 0.01), but the mean reduction, 23 +/- 6%, was significantly less than in Veh Rx rats (P less than 10(-4].	Capsaicin	3-12	cholecystokinin	Rattus norvegicus	33-36
2413505-14	1985	These studies demonstrate that peripheral CCK-satiety is partly mediated by capsaicin sensitive fibers, presumably in the vagus nerve.	Capsaicin	76-85	cholecystokinin	Rattus norvegicus	42-45
2415872-4	1985	In adult animals treated neonatally with capsaicin adenosine deaminase-positive fibers were totally depleted in layer IIo but only partially depleted in layer I.	Capsaicin	41-50	adenosine deaminase	Rattus norvegicus	51-70
2408483-0	1985	Capsaicin effects on muscularis mucosa of opossum esophagus: substance P release from afferent nerves?	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	61-72
2408483-10	1985	Capsaicin reduced responses to exogenous substance P or carbachol only partially.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	41-52
2410425-4	1985	In the presence of atropine, morphine, guanethidine and 6-hydroxydopamine, the contraction produced by periarterial nerve stimulation was readily abolished by tetrodotoxin (1 microM), capsaicin (3.3 microM) and an SP-antagonist (SPA1, 10 microM).	Capsaicin	184-193	signal-induced proliferation-associated 1	Rattus norvegicus	229-233
2581820-4	1985	Capsaicin interferes with the retrograde transport of nerve growth factor (NGF) to the cell bodies of sensory nerves.	Capsaicin	0-9	beta-nerve growth factor	Cavia porcellus	54-73
2581820-4	1985	Capsaicin interferes with the retrograde transport of nerve growth factor (NGF) to the cell bodies of sensory nerves.	Capsaicin	0-9	beta-nerve growth factor	Cavia porcellus	75-78
2415955-1	1985	Immunohistochemical and radioimmunoassay studies revealed that both CGRP- and SP-like immunoreactivity in the caudal spinal trigeminal nucleus and tract, the substantia gelatinosa and the dorsal cervical spinal cord as well as in cell bodies of the trigeminal ganglion and the spinal dorsal root ganglion is markedly depleted by capsaicin which is known to cause degeneration of a certain number of primary sensory neurons.	Capsaicin	329-338	calcitonin-related polypeptide alpha	Rattus norvegicus	68-72
3922012-4	1985	Neonatal treatment with capsaicin or acute vagotomy also produced adult animals whose basal PaCO2 was elevated and whose respiratory response to TRH was greater than that seen in control rats with lower PaCO2 values.	Capsaicin	24-33	thyrotropin releasing hormone	Rattus norvegicus	145-148
3896362-0	1985	Pressor sensitivity to exogenous vasopressin in conscious, adult rats treated neonatally with capsaicin.	Capsaicin	94-103	arginine vasopressin	Rattus norvegicus	33-44
3896362-7	1985	From the present findings, it seems that our previous observation of impaired, vasopressin-mediated blood pressure recovery following acute hypotension in capsaicin-treated rats cannot be attributed to a reduced pressor sensitivity to the hormone.	Capsaicin	155-164	arginine vasopressin	Rattus norvegicus	79-90
3986564-3	1985	The method is used for the quantitative description of the consequences of neonatal capsaicin treatment, and the results appear to justify the attribution of the TRAP activity to the capsaicin sensitive neurons.	Capsaicin	84-93	tudor domain containing 7	Rattus norvegicus	162-166
3986564-3	1985	The method is used for the quantitative description of the consequences of neonatal capsaicin treatment, and the results appear to justify the attribution of the TRAP activity to the capsaicin sensitive neurons.	Capsaicin	183-192	tudor domain containing 7	Rattus norvegicus	162-166
3986564-6	1985	At all ages (1-4 weeks) TRAP activity was reduced 50-60% in capsaicin-treated DRG.	Capsaicin	60-69	tudor domain containing 7	Rattus norvegicus	24-28
3986564-9	1985	TRAP activity was found to be decreased 38% in the dorsal half of the lumbar spinal cord (L3-L5), decreased 33% in nodose ganglion, and unchanged in superior cervical ganglion of the capsaicin treated animals.	Capsaicin	183-192	tudor domain containing 7	Rattus norvegicus	0-4
2579983-6	1985	The sensory nature of the CGRP-immunoreactive fibres was substantiated by the depletion of CGRP immunoreactivity observed after treatment with capsaicin, which is known to cause selective degeneration of sensory neurons.	Capsaicin	143-152	calcitonin related polypeptide alpha	Homo sapiens	26-30
2579983-6	1985	The sensory nature of the CGRP-immunoreactive fibres was substantiated by the depletion of CGRP immunoreactivity observed after treatment with capsaicin, which is known to cause selective degeneration of sensory neurons.	Capsaicin	143-152	calcitonin related polypeptide alpha	Homo sapiens	91-95
3858706-0	1985	Regional distribution of a novel pituitary protein (7B2) in the rat spinal cord: effect of neonatal capsaicin treatment and thoracic cord transection.	Capsaicin	100-109	secretogranin V	Rattus norvegicus	52-55
3875838-0	1985	Corticotropin releasing factor-like immunoreactivity in sensory ganglia and capsaicin sensitive neurons of the rat central nervous system: colocalization with other neuropeptides.	Capsaicin	76-85	corticotropin releasing hormone	Rattus norvegicus	0-30
3875838-4	1985	Capsaicin treatment of neonatal rats resulted in a marked decrease in the density of CRF-, SP-, VIP- and CCK-containing neurons in the above mentioned hindbrain areas, whereas SST- and LENK-immunoreactivity were not changed.	Capsaicin	0-9	vasoactive intestinal peptide	Rattus norvegicus	96-99
3875838-4	1985	Capsaicin treatment of neonatal rats resulted in a marked decrease in the density of CRF-, SP-, VIP- and CCK-containing neurons in the above mentioned hindbrain areas, whereas SST- and LENK-immunoreactivity were not changed.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	105-108
3875838-5	1985	RIA revealed that, compared to controls, CRF, SP and VIP concentrations in these areas were decreased in rats pretreated with capsaicin, while SST levels were increased; CCK and LENK levels were unchanged.	Capsaicin	126-135	vasoactive intestinal peptide	Rattus norvegicus	53-56
4016888-0	1985	Capsaicin-induced inhibition of axoplasmic transport is prevented by nerve growth factor.	Capsaicin	0-9	nerve growth factor	Rattus norvegicus	69-88
2580718-0	1985	Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin.	Capsaicin	170-179	tachykinin precursor 1	Homo sapiens	16-27
2580718-0	1985	Co-existence of substance P and calcitonin gene-related peptide-like immunoreactivities in sensory nerves in relation to cardiovascular and bronchoconstrictor effects of capsaicin.	Capsaicin	170-179	calcitonin related polypeptide alpha	Homo sapiens	32-63
2580718-1	1985	Immunohistochemical studies showed that substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity co-exist in capsaicin-sensitive primary sensory neurons.	Capsaicin	129-138	tachykinin precursor 1	Homo sapiens	40-51
2580718-1	1985	Immunohistochemical studies showed that substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity co-exist in capsaicin-sensitive primary sensory neurons.	Capsaicin	129-138	calcitonin related polypeptide alpha	Homo sapiens	61-92
2580718-1	1985	Immunohistochemical studies showed that substance P (SP) and calcitonin gene-related peptide (CGRP) immunoreactivity co-exist in capsaicin-sensitive primary sensory neurons.	Capsaicin	129-138	calcitonin related polypeptide alpha	Homo sapiens	94-98
3871192-3	1985	Treatment of neonatal rats with capsaicin and ablation of the central portion of the feline nodose ganglion led to a marked reduction in the numbers of CGRP-immunoreactive nerve fibers.	Capsaicin	32-41	calcitonin-related polypeptide alpha	Rattus norvegicus	152-156
3871192-4	1985	The loss of CGRP nerves demonstrated by immunocytochemistry was accompanied by a parallel reduction in the tissue content of CGRP, as measured by radioimmunoassay (1.5 +/- 0.5 pmol/g in capsaicin-treated animals compared with 9.4 +/- 1.9 pmol/g in vehicle-treated controls; p less than 0.0025).	Capsaicin	186-195	calcitonin-related polypeptide alpha	Rattus norvegicus	12-16
3871192-4	1985	The loss of CGRP nerves demonstrated by immunocytochemistry was accompanied by a parallel reduction in the tissue content of CGRP, as measured by radioimmunoassay (1.5 +/- 0.5 pmol/g in capsaicin-treated animals compared with 9.4 +/- 1.9 pmol/g in vehicle-treated controls; p less than 0.0025).	Capsaicin	186-195	calcitonin-related polypeptide alpha	Rattus norvegicus	125-129
2411409-10	1985	Neuropeptide Y- and tyrosine hydroxylase-like immunoreactivity was reduced by the same magnitude after treatment with the sympathetic neurotoxin 6-hydroxydopamine, but it was not affected by the primary sensory neurotoxin capsaicin.	Capsaicin	222-231	pro-neuropeptide Y	Cavia porcellus	0-14
4016888-4	1985	Injection of nerve growth factor (NGF) into the pudendal nerve prevented the deleterious effects of capsaicin, thereby suggesting a possible site of action and mechanism for the effect of capsaicin on peripheral nerves.	Capsaicin	100-109	nerve growth factor	Rattus norvegicus	13-32
4016888-4	1985	Injection of nerve growth factor (NGF) into the pudendal nerve prevented the deleterious effects of capsaicin, thereby suggesting a possible site of action and mechanism for the effect of capsaicin on peripheral nerves.	Capsaicin	100-109	nerve growth factor	Rattus norvegicus	34-37
4016888-4	1985	Injection of nerve growth factor (NGF) into the pudendal nerve prevented the deleterious effects of capsaicin, thereby suggesting a possible site of action and mechanism for the effect of capsaicin on peripheral nerves.	Capsaicin	188-197	nerve growth factor	Rattus norvegicus	13-32
4016888-4	1985	Injection of nerve growth factor (NGF) into the pudendal nerve prevented the deleterious effects of capsaicin, thereby suggesting a possible site of action and mechanism for the effect of capsaicin on peripheral nerves.	Capsaicin	188-197	nerve growth factor	Rattus norvegicus	34-37
3884554-6	1985	Following capsaicin treatment a small depletion in CGRP-immunoreactive nerve fibres in the rat palate epithelium was noted.	Capsaicin	10-19	calcitonin-related polypeptide alpha	Rattus norvegicus	51-55
3884554-9	1985	The reduction in the number of visible immunoreactive nerves following capsaicin application tends to confirm the sensory character of the CGRP-containing nerve fibres terminating in the epithelium of the hard and soft palate.	Capsaicin	71-80	calcitonin related polypeptide alpha	Homo sapiens	139-143
6194478-3	1983	The drug capsaicin released substance P at concentrations greater than 10(-8) M. Both potassium- and capsaicin-induced release were abolished by omitting calcium ions from the superfusion buffer.	Capsaicin	9-18	tachykinin precursor 1	Bos taurus	28-39
6528310-7	1984	Capsaicin also inhibited ATP release induced by thrombin and A23187 in the presence of EDTA.	Capsaicin	0-9	coagulation factor II	Rattus norvegicus	48-56
6528310-8	1984	MDA and TXB2 formation were markedly inhibited by capsaicin in platelets challenged by collagen, thrombin and A23187.	Capsaicin	50-59	coagulation factor II	Rattus norvegicus	97-105
6528310-12	1984	It was concluded that capsaicin had some membrane stabilizing property and this might lead to the interference of the activation of phospholipase A2.	Capsaicin	22-31	phospholipase A2 group IB	Rattus norvegicus	132-148
6529968-2	1984	Plasma extravasation by nerve growth factor was markedly reduced by capsaicin pretreatment or a combination of H1- and H2-histamine antagonists.	Capsaicin	68-77	nerve growth factor	Rattus norvegicus	24-43
6377113-0	1984	Capsaicin depletes corticotropin-releasing factor-like immunoreactive neurons in the rat spinal cord and medulla oblongata.	Capsaicin	0-9	corticotropin releasing hormone	Rattus norvegicus	19-49
6377113-1	1984	Treatment of newborn rats with capsaicin was shown to cause a disappearance of corticotropin-releasing factor immunoreactive nerve fibers in the dorsal horn of the spinal cord (laminae I and II), the spinal trigeminal nucleus and tract, and the nucleus tractus solitarius, but not in the median eminence and the nucleus amygdaloideus centralis.	Capsaicin	31-40	corticotropin releasing hormone	Rattus norvegicus	79-109
6377113-2	1984	Since it is well known that capsaicin acts selectively on primary sensory neurons of the C-fiber type, it is suggested that corticotropin-releasing factor is also located in peripheral sensory neurons, representing a novel peptidergic neuronal system, possibly involved in the modulation or transmission of peripheral nociceptive impulses, which is different from the capsaicin-resistant hypothalamoinfundibular corticotropin-releasing factor system.	Capsaicin	28-37	corticotropin releasing hormone	Rattus norvegicus	124-154
6377113-2	1984	Since it is well known that capsaicin acts selectively on primary sensory neurons of the C-fiber type, it is suggested that corticotropin-releasing factor is also located in peripheral sensory neurons, representing a novel peptidergic neuronal system, possibly involved in the modulation or transmission of peripheral nociceptive impulses, which is different from the capsaicin-resistant hypothalamoinfundibular corticotropin-releasing factor system.	Capsaicin	368-377	corticotropin releasing hormone	Rattus norvegicus	124-154
6704593-0	1984	Neonatal capsaicin treatment impairs vasopressin-mediated blood pressure recovery following acute hypotension.	Capsaicin	9-18	arginine vasopressin	Rattus norvegicus	37-48
6704593-7	1984	These results suggest that neonatal treatment with capsaicin impairs vasopressin-mediated recovery of blood pressure following acute hypotension.	Capsaicin	51-60	arginine vasopressin	Rattus norvegicus	69-80
6202097-8	1984	Miosis caused by SP, trigeminal stimulation, capsaicin, PGE1, compound 48/80 or histamine was blocked by (D-Arg1, D-Pro2, D-Trp7,9, Leu11)-SP.	Capsaicin	45-54	arginase-1	Oryctolagus cuniculus	108-112
24874140-0	1984	Effects of neonatal capsaicin treatment on thiamine monophosphatase (TMPase) activity in the substantia gelatinosa of the rat spinal cord.	Capsaicin	20-29	acid phosphatase 3	Rattus norvegicus	43-67
24874140-0	1984	Effects of neonatal capsaicin treatment on thiamine monophosphatase (TMPase) activity in the substantia gelatinosa of the rat spinal cord.	Capsaicin	20-29	acid phosphatase 3	Rattus norvegicus	69-75
24874140-1	1984	The present study investigated changes in gelatinosal TMPase activity following capsaicin treatment.	Capsaicin	80-89	acid phosphatase 3	Rattus norvegicus	54-60
24874140-2	1984	The gelatinosal TMPase activity was positive around postnatal day 3, and the activity disappeared when newborn rats were treated with capsaicin on postnatal days 2 or 3.	Capsaicin	134-143	acid phosphatase 3	Rattus norvegicus	16-22
6196939-8	1983	The presence of capsaicin-induced bronchial contractions however indicates the existence of a local non-cholinergic axon-reflex control of bronchial smooth muscle tone by substance P in man.	Capsaicin	16-25	tachykinin precursor 1	Homo sapiens	171-182
6197700-0	1983	The effects of cysteamine and capsaicin on somatostatin and substance P in medullary nuclei.	Capsaicin	30-39	tachykinin precursor 1	Homo sapiens	60-71
6197700-2	1983	In contrast, capsaicin, the putative neurotoxin for primary sensory afferent neurons had no effect on the somatostatin content of any of the medullary nuclei assayed while depleting the substance P content of the spinal trigeminal nucleus in the same animals.	Capsaicin	13-22	tachykinin precursor 1	Homo sapiens	186-197
6194478-3	1983	The drug capsaicin released substance P at concentrations greater than 10(-8) M. Both potassium- and capsaicin-induced release were abolished by omitting calcium ions from the superfusion buffer.	Capsaicin	101-110	tachykinin precursor 1	Bos taurus	28-39
6194478-4	1983	When subjected to separation by reverse phase high performance liquid chromatography, the superfusate from capsaicin perfused tissues contained a peak of immunoreactivity which migrated at the retention time corresponding to substance P.	Capsaicin	107-116	tachykinin precursor 1	Bos taurus	225-236
6189618-5	1983	Substance-P-immunoreactivity is almost totally abolished by treatment of animals with capsaicin, an agent known to deplete substance P from primary sensory neurons.	Capsaicin	86-95	tachykinin 1	Mus musculus	0-11
6622833-6	1983	After one month of oral administration of capsaicin or capsicum, there were significant reductions of plasma urea nitrogen, glucose, phospholipids, triglycerides, total cholesterol, free fatty acids, glutamic pyruvic transaminase, and alkaline phosphatase.	Capsaicin	42-51	glutamic--pyruvic transaminase	Rattus norvegicus	200-255
6185853-0	1983	Nerve growth factor antagonizes the neurotoxic action of capsaicin on primary sensory neurones.	Capsaicin	57-66	nerve growth factor	Rattus norvegicus	0-19
6185853-5	1983	Treatment of newborn rats with capsaicin led to degeneration of primary sensory neurones containing substance P, somatostatin, vasoactive intestinal polypeptide and cholecystokinin.	Capsaicin	31-40	somatostatin	Rattus norvegicus	113-125
6185853-7	1983	We report here that in newborn rats concomitant administration of NGF partially antagonized the deleterious effect of capsaicin on substance P-containing neurones in dorsal root ganglia as assessed by morphological and biochemical criteria.	Capsaicin	118-127	nerve growth factor	Rattus norvegicus	66-69
6185853-8	1983	We conclude that capsaicin destroys the perikarya of primary sensory peptidergic neurones by interfering with the action of NGF, probably by blocking its retrograde axonal transport.	Capsaicin	17-26	nerve growth factor	Rattus norvegicus	124-127
6133573-0	1983	Topical capsaicin pretreatment inhibits axon reflex vasodilatation caused by somatostatin and vasoactive intestinal polypeptide in human skin.	Capsaicin	8-17	somatostatin	Homo sapiens	77-89
6185658-6	1983	In all of the structures examined, particularly the dorsal roots, a roughly parallel decrease of substance P and somatostatin was found with capsaicin dose.	Capsaicin	141-150	somatostatin	Rattus norvegicus	113-125
6185658-7	1983	The depletions of spinal cord substance P (55%) and somatostatin (20%) produced by neonatal capsaicin treatment were similar to those produced by dorsal rhizotomy.	Capsaicin	92-101	somatostatin	Rattus norvegicus	52-64
6189034-0	1983	The effects of prenatal capsaicin on the distribution of substance P in developing primary afferent neurons.	Capsaicin	24-33	tachykinin 1	Mus musculus	57-68
6189034-3	1983	Capsaicin administered to either the mother or the foetus crossed the placenta and depleted substance P from the primary afferent terminal field in the spinal cord and abolished reactivity in the dorsal root ganglia and peripheral terminals of spinal nerves.	Capsaicin	0-9	tachykinin 1	Mus musculus	92-103
6194652-0	1983	Inhibition of smooth muscle contractions induced by capsaicin and electrical transmural stimulation by a substance P antagonist.	Capsaicin	52-61	tachykinin precursor 1	Homo sapiens	105-116
6210001-8	1983	Substance P-containing nerves are affected by capsaicin, supporting the hypothesis that these are primary sensory afferents, perhaps mediating pain.	Capsaicin	46-55	tachykinin precursor 1	Homo sapiens	0-11
6189618-5	1983	Substance-P-immunoreactivity is almost totally abolished by treatment of animals with capsaicin, an agent known to deplete substance P from primary sensory neurons.	Capsaicin	86-95	tachykinin 1	Mus musculus	123-134
6193989-5	1983	The recent findings suggest a hypothesis of a local reflex arch involving antidromic vasodilation by afferent, capsaicin sensitive SP neurones and parasympathetic VIP-cholinergic neurones in the efferent response.	Capsaicin	111-120	tachykinin precursor 1	Homo sapiens	131-133
6199960-0	1983	[Effects of bradykinin and capsaicin on substance P-induced reactions in the iris sphincter muscle].	Capsaicin	27-36	tachykinin precursor 1	Homo sapiens	40-51
6200737-0	1983	Enkephalin-like immunofluorescence in nerves of the rat iris following systemic capsaicin injection.	Capsaicin	80-89	proenkephalin	Rattus norvegicus	0-10
6200737-3	1983	The enkephalin-immunoreactive network seemed intact also after a capsaicin dose of 250 mg/kg.	Capsaicin	65-74	proenkephalin	Rattus norvegicus	4-14
6200737-4	1983	In fact, the fluorescence intensity of the nerve fibers showing enkephalin-immunoreactivity was often increased three days after a capsaicin injection in a dose of 50 mg/kg.	Capsaicin	131-140	proenkephalin	Rattus norvegicus	64-74
6200737-5	1983	The mechanism behind this effect of capsaicin remains to be elucidated, but could be due either to a direct effect on the enkephalin-positive nerves or involve the disappearance of substance P nerves and/or a simultaneous inflammatory response.	Capsaicin	36-45	proenkephalin	Rattus norvegicus	122-132
6200737-6	1983	However, an increased fluorescence intensity of the enkephalin-immunoreactive fibers was sometimes seen also without capsaicin treatment.	Capsaicin	117-126	proenkephalin	Rattus norvegicus	52-62
6182949-0	1982	Regulation of substance P by nerve growth factor: disruption by capsaicin.	Capsaicin	64-73	tachykinin 1	Mus musculus	14-25
6183713-2	1982	Capsaicin, which depletes substance P-like immunoreactivity from sensory, but not from other substance P-containing nerves, reduced the content of substance P-like immunoreactivity in ureter, atrium and superior mesenteric artery by more than 99.5%, whereas the reduction in immunoreactive material in the myenteric plexus was less than 10%.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	26-37
6183713-2	1982	Capsaicin, which depletes substance P-like immunoreactivity from sensory, but not from other substance P-containing nerves, reduced the content of substance P-like immunoreactivity in ureter, atrium and superior mesenteric artery by more than 99.5%, whereas the reduction in immunoreactive material in the myenteric plexus was less than 10%.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	93-104
6183713-2	1982	Capsaicin, which depletes substance P-like immunoreactivity from sensory, but not from other substance P-containing nerves, reduced the content of substance P-like immunoreactivity in ureter, atrium and superior mesenteric artery by more than 99.5%, whereas the reduction in immunoreactive material in the myenteric plexus was less than 10%.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	93-104
7162630-4	1982	Fourteen days after a single application of 49 mM solution of capsaicin a significant depletion of substance P and somatostatin was detected.	Capsaicin	62-71	somatostatin	Rattus norvegicus	115-127
6173821-0	1981	Depletion by capsaicin of substance P-immunoreactivity and acetylcholinesterase activity from nerve fibres in the guinea-pig heart.	Capsaicin	13-22	acetylcholinesterase	Cavia porcellus	26-79
6173821-4	1981	Capsaicin treatment also decreased the number of visible AChE-positive nerve fibres.	Capsaicin	0-9	acetylcholinesterase	Cavia porcellus	57-61
6170896-0	1981	Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat.	Capsaicin	24-33	somatostatin	Rattus norvegicus	52-64
6170896-0	1981	Differential effects of capsaicin on the content of somatostatin, substance P, and neurotensin in the nervous system of the rat.	Capsaicin	24-33	neurotensin	Rattus norvegicus	83-94
6166346-2	1981	At the same time heat pain thresholds were reduced on average by 3.5 degrees C. These results are consistent with block by capsaicin of the effector side of the axon reflex, perhaps by depleting nerve terminals of substance P.	Capsaicin	123-132	tachykinin precursor 1	Homo sapiens	214-225
6182949-5	1982	It is concluded that capsaicin depletes substance P from primary afferent neurons of the adult guinea pig by altering the availability of NGF.	Capsaicin	21-30	tachykinin 1	Mus musculus	40-51
6180272-3	1982	Newer investigations using the compound capsaicin are consistent with the hypothesis that substance P is an important neurochemical mediator of certain kinds of noxious peripheral stimuli.	Capsaicin	40-49	tachykinin precursor 1	Homo sapiens	90-101
6178469-0	1982	Capsaicin applied to peripheral nerve inhibits axoplasmic transport of substance P and somatostatin.	Capsaicin	0-9	somatostatin	Rattus norvegicus	87-99
6178469-2	1982	Capsaicin (10 mg/ml) led to a complete block of axoplasmic transport of immunoreactive substance P (I-SP) and somatostatin (I-SRIF) in rat sciatic nerve without affecting the transport of noradrenaline or acetylcholinesterase.	Capsaicin	0-9	somatostatin	Rattus norvegicus	87-122
6179017-3	1982	However substance P levels were reduced by 42% following surgical denervation and by 80% following neonatal capsaicin treatment, suggesting that corneal substance P is contained in the peripheral terminals of small diameter sensory neurones.	Capsaicin	108-117	tachykinin 1	Mus musculus	8-19
6179017-3	1982	However substance P levels were reduced by 42% following surgical denervation and by 80% following neonatal capsaicin treatment, suggesting that corneal substance P is contained in the peripheral terminals of small diameter sensory neurones.	Capsaicin	108-117	tachykinin 1	Mus musculus	153-164
6765219-0	1982	Capsaicin depletes CCK-like immunoreactivity detected by immunohistochemistry, but not that measured by radioimmunoassay in rat dorsal spinal cord.	Capsaicin	0-9	cholecystokinin	Rattus norvegicus	19-22
20487851-2	1982	It has been shown previously that the effects of capsaicin are accompanied by the loss of substance P from areas of primary afferent termination and that enkephalin is not depleted from such areas.	Capsaicin	49-58	tachykinin precursor 1	Homo sapiens	90-101
20487851-4	1982	Neonatal capsaicin treatment produces a depletion of somatostatin and cholecystokinin immunofluorescence in addition to substance P, but enkephalin and neurotensin immunofluorescence are not depleted.	Capsaicin	9-18	tachykinin precursor 1	Homo sapiens	120-131
6170855-0	1981	Capsaicin and potassium evoked substance P release from the nucleus tractus solitarius and spinal trigeminal nucleus in vitro.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	31-42
6182949-0	1982	Regulation of substance P by nerve growth factor: disruption by capsaicin.	Capsaicin	64-73	beta-nerve growth factor	Cavia porcellus	29-48
6182949-1	1982	Capsaicin depleted substance P from guinea pig dorsal root ganglia and inhibited the retrograde axoplasmic transport of nerve growth factor (NGF).	Capsaicin	0-9	tachykinin 1	Mus musculus	19-30
6182949-1	1982	Capsaicin depleted substance P from guinea pig dorsal root ganglia and inhibited the retrograde axoplasmic transport of nerve growth factor (NGF).	Capsaicin	0-9	beta-nerve growth factor	Cavia porcellus	120-139
6182949-1	1982	Capsaicin depleted substance P from guinea pig dorsal root ganglia and inhibited the retrograde axoplasmic transport of nerve growth factor (NGF).	Capsaicin	0-9	beta-nerve growth factor	Cavia porcellus	141-144
6182949-2	1982	Doses of capsaicin which depleted substance P also inhibited the retrograde axoplasmic transport of NGF.	Capsaicin	9-18	tachykinin 1	Mus musculus	34-45
6182949-2	1982	Doses of capsaicin which depleted substance P also inhibited the retrograde axoplasmic transport of NGF.	Capsaicin	9-18	beta-nerve growth factor	Cavia porcellus	100-103
6182949-3	1982	Inhibition of the retrograde transport of NGF by capsaicin preceded substance P depletion.	Capsaicin	49-58	beta-nerve growth factor	Cavia porcellus	42-45
6182949-4	1982	Supplementation of guinea pigs with mouse NGF completely prevented capsaicin-induced substance P depletion.	Capsaicin	67-76	nerve growth factor	Mus musculus	42-45
6182949-4	1982	Supplementation of guinea pigs with mouse NGF completely prevented capsaicin-induced substance P depletion.	Capsaicin	67-76	tachykinin 1	Mus musculus	85-96
6182949-5	1982	It is concluded that capsaicin depletes substance P from primary afferent neurons of the adult guinea pig by altering the availability of NGF.	Capsaicin	21-30	beta-nerve growth factor	Cavia porcellus	138-141
6164737-2	1981	Depletion of substance P from local sensory nerve terminals is suggested as a possible explanation for this capsaicin effect.	Capsaicin	108-117	tachykinin precursor 1	Homo sapiens	13-24
6164015-0	1981	Immunoreactive substance P in sympathetic ganglia: distribution and sensitivity towards capsaicin.	Capsaicin	88-97	tachykinin precursor 1	Homo sapiens	15-26
6168921-0	1981	Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons.	Capsaicin	10-19	somatostatin	Rattus norvegicus	79-91
6168921-0	1981	Effect of capsaicin pretreatment on capsaicin-evoked release of immunoreactive somatostatin and substance P from primary sensory neurons.	Capsaicin	36-45	somatostatin	Rattus norvegicus	79-91
6163995-0	1981	Substance P immunoreactive neurons following neonatal administration of capsaicin.	Capsaicin	72-81	tachykinin precursor 1	Homo sapiens	0-11
6163995-1	1981	Neonatal administration of capsaicin on the days 2, 10 or 20 leads to a long-lasting loss of substance P immunoreactive material in fibers of primary sensory neurons in the spinal cord and medulla oblongata.	Capsaicin	27-36	tachykinin precursor 1	Homo sapiens	93-104
6153545-7	1980	Somatostatin, vasoactive intestinal polypeptide, caerulein and the enkephalin-analogue FK 33-824 were ineffective in doses 100 fold higher.6 The results indicate that the action of capsaicin on substance P neurones is restricted to primary sensory neurones.	Capsaicin	181-190	proenkephalin	Rattus norvegicus	67-77
6178091-4	1981	Its transport and release at afferent terminals is further validated by the significant depletion of substance P which occurred in the corresponding tissue after ligation of a sensory nerve (vagus), destruction of a ganglion (i.e., Gasserian ganglion leading to depletion from ocular structures) and treatment with capsaicin.	Capsaicin	315-324	tachykinin precursor 1	Homo sapiens	101-112
502756-0	1979	Substance P release from spinal cord slices by capsaicin.	Capsaicin	47-56	tachykinin precursor 1	Homo sapiens	0-11
41996-0	1979	Pharmacologic actions of capsaicin: apparent involvement of substance P and serotonin.	Capsaicin	25-34	tachykinin precursor 1	Homo sapiens	60-71
466404-0	1979	Capsaicin-evoked release of substance P from primary sensory neurons.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	28-39
209869-0	1978	Capsaicin-induced depletion of substance P from primary sensory neurones.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	31-42
34043299-1	2021	Transient receptor potential vanilloid (TRPV) channels are part of the TRP channel superfamily and named after the first identified member TRPV1, that is sensitive to the vanillylamide capsaicin.	Capsaicin	185-194	transient receptor potential cation channel subfamily V member 1	Homo sapiens	139-144
33525904-7	2021	RESULTS: Inhibition of TRESK increased the TRPV1-mediated calcium signal in dorsal root ganglion neurons and potentiated capsaicin-induced increases in calcitonin gene-related peptide release and meningeal blood flow.	Capsaicin	121-130	potassium channel, subfamily K, member 18	Mus musculus	23-28
33525904-8	2021	Activation of TRESK decreased the capsaicin sensitivity of sensory neurons, leading to an attenuation of capsaicin-induced increase in meningeal blood flow.	Capsaicin	34-43	potassium channel, subfamily K, member 18	Mus musculus	14-19
33525904-8	2021	Activation of TRESK decreased the capsaicin sensitivity of sensory neurons, leading to an attenuation of capsaicin-induced increase in meningeal blood flow.	Capsaicin	105-114	potassium channel, subfamily K, member 18	Mus musculus	14-19
33677213-0	2021	Bovine alpha-lactalbumin assemblies with capsaicin: Formation, interactions, loading and physiochemical characterization.	Capsaicin	41-50	lactalbumin alpha	Bos taurus	7-24
33839411-2	2021	TRPV1 has at least three distinct activation modes that are selectively induced by different stimuli capsaicin, noxious heat, and protons.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
33839411-6	2021	Here, we show that eugenol dose-dependently inhibited the capsaicin-activated inward currents of mouse TRPV1 expressed in human embryonic kidney 293 (HEK293) cells.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	103-108
33631206-4	2021	We activated neurons in isolated dorsal root and trigeminal ganglia from mice with capsaicin (5 microM), which acts on transient receptor potential vanilloid type 1 (TRPV1) channels in small neurons.	Capsaicin	83-92	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	119-164
33631206-4	2021	We activated neurons in isolated dorsal root and trigeminal ganglia from mice with capsaicin (5 microM), which acts on transient receptor potential vanilloid type 1 (TRPV1) channels in small neurons.	Capsaicin	83-92	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	166-171
33631206-5	2021	We found that capsaicin induced SGC activation, as assayed by glial fibrillary acidic protein (GFAP) upregulation, and an NO-donor had a similar effect.	Capsaicin	14-23	serglycin	Mus musculus	32-35
33631206-5	2021	We found that capsaicin induced SGC activation, as assayed by glial fibrillary acidic protein (GFAP) upregulation, and an NO-donor had a similar effect.	Capsaicin	14-23	glial fibrillary acidic protein	Mus musculus	62-93
33631206-5	2021	We found that capsaicin induced SGC activation, as assayed by glial fibrillary acidic protein (GFAP) upregulation, and an NO-donor had a similar effect.	Capsaicin	14-23	glial fibrillary acidic protein	Mus musculus	95-99
33631206-6	2021	Incubating the ganglia in capsaicin in the presence of the NO-synthase inhibitor L-NAME (100 microM) prevented the GFAP upregulation.	Capsaicin	26-35	glial fibrillary acidic protein	Mus musculus	115-119
33631206-7	2021	We also found that capsaicin caused an increase in SGC-SGC coupling, which was shown previously to accompany SGC activation.	Capsaicin	19-28	serglycin	Mus musculus	51-54
33631206-7	2021	We also found that capsaicin caused an increase in SGC-SGC coupling, which was shown previously to accompany SGC activation.	Capsaicin	19-28	serglycin	Mus musculus	55-58
33631206-7	2021	We also found that capsaicin caused an increase in SGC-SGC coupling, which was shown previously to accompany SGC activation.	Capsaicin	19-28	serglycin	Mus musculus	55-58
33631206-8	2021	To test the contribution of ATP to the actions of capsaicin, we incubated the ganglia with capsaicin in the presence of P2 purinergic receptor inhibitor suramin (100 microM), which prevented the capsaicin-induced GFAP upregulation.	Capsaicin	91-100	glial fibrillary acidic protein	Mus musculus	213-217
33631206-8	2021	To test the contribution of ATP to the actions of capsaicin, we incubated the ganglia with capsaicin in the presence of P2 purinergic receptor inhibitor suramin (100 microM), which prevented the capsaicin-induced GFAP upregulation.	Capsaicin	91-100	glial fibrillary acidic protein	Mus musculus	213-217
32781866-6	2021	TRPA1, TRPM2 and TRPV1 of the eight groups were further stimulated by cinnamaldehyde, cumene hydyroperoxide and capsaicin, respectively although they were further inhibited by AP-18, N-(p-Amylcinnamoyl) anthranilic acid (ACA) and capsazepine (CPZ).	Capsaicin	112-121	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
32781866-6	2021	TRPA1, TRPM2 and TRPV1 of the eight groups were further stimulated by cinnamaldehyde, cumene hydyroperoxide and capsaicin, respectively although they were further inhibited by AP-18, N-(p-Amylcinnamoyl) anthranilic acid (ACA) and capsazepine (CPZ).	Capsaicin	112-121	transient receptor potential cation channel subfamily M member 2	Homo sapiens	7-12
32781866-6	2021	TRPA1, TRPM2 and TRPV1 of the eight groups were further stimulated by cinnamaldehyde, cumene hydyroperoxide and capsaicin, respectively although they were further inhibited by AP-18, N-(p-Amylcinnamoyl) anthranilic acid (ACA) and capsazepine (CPZ).	Capsaicin	112-121	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
34006826-7	2021	In the rat OA model, intra-articular injection of capsaicin (CPS), a specific TRPV1 agonist, significantly attenuated OA phenotypes, including joint swelling, synovitis, cartilage damage, and osteophyte formation.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-83
34006826-7	2021	In the rat OA model, intra-articular injection of capsaicin (CPS), a specific TRPV1 agonist, significantly attenuated OA phenotypes, including joint swelling, synovitis, cartilage damage, and osteophyte formation.	Capsaicin	61-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-83
33277125-1	2021	In this work, capsaicin (CAP) was loaded into mesoporous silica nanoparticles (MSNs) with grain diameters of 50 nm, 100 nm and 400 nm by free diffusion to obtain the support materials Cap@MSN-50, Cap@MSN-100 and Cap@MSN-400, respectively.	Capsaicin	14-23	moesin	Homo sapiens	79-82
33277125-1	2021	In this work, capsaicin (CAP) was loaded into mesoporous silica nanoparticles (MSNs) with grain diameters of 50 nm, 100 nm and 400 nm by free diffusion to obtain the support materials Cap@MSN-50, Cap@MSN-100 and Cap@MSN-400, respectively.	Capsaicin	14-23	moesin	Homo sapiens	188-191
33277125-1	2021	In this work, capsaicin (CAP) was loaded into mesoporous silica nanoparticles (MSNs) with grain diameters of 50 nm, 100 nm and 400 nm by free diffusion to obtain the support materials Cap@MSN-50, Cap@MSN-100 and Cap@MSN-400, respectively.	Capsaicin	14-23	moesin	Homo sapiens	188-191
33197270-4	2021	Differential (ibuprofen or capsaicin) response was defined when change-from-baseline pain intensity scores (0-10 NRS) differed by >=1 between treatments in >=2 cycles within a participant.	Capsaicin	27-36	sphingolipid transporter 1 (putative)	Homo sapiens	113-116
33956370-6	2021	Administration of a TRPV1 agonist, capsaicin, increases levels of phosphorylated p70S6K (p-p70S6K; activation of p70S6K) on astrocytes, resulting in the survival of dopamine neurons and behavioral recovery through endogenous production of CNTF in the MPP+ -lesioned rat model of PD.	Capsaicin	35-44	ribosomal protein S6 kinase B1	Rattus norvegicus	91-97
33956370-6	2021	Administration of a TRPV1 agonist, capsaicin, increases levels of phosphorylated p70S6K (p-p70S6K; activation of p70S6K) on astrocytes, resulting in the survival of dopamine neurons and behavioral recovery through endogenous production of CNTF in the MPP+ -lesioned rat model of PD.	Capsaicin	35-44	ciliary neurotrophic factor	Rattus norvegicus	239-243
33956370-6	2021	Administration of a TRPV1 agonist, capsaicin, increases levels of phosphorylated p70S6K (p-p70S6K; activation of p70S6K) on astrocytes, resulting in the survival of dopamine neurons and behavioral recovery through endogenous production of CNTF in the MPP+ -lesioned rat model of PD.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	20-25
33493995-3	2021	Topical capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has been proposed in recent years as a low-cost and effective alternative to the traditional antiemetic regimen when treating CHS.	Capsaicin	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-61
33956370-6	2021	Administration of a TRPV1 agonist, capsaicin, increases levels of phosphorylated p70S6K (p-p70S6K; activation of p70S6K) on astrocytes, resulting in the survival of dopamine neurons and behavioral recovery through endogenous production of CNTF in the MPP+ -lesioned rat model of PD.	Capsaicin	35-44	ribosomal protein S6 kinase B1	Rattus norvegicus	81-87
33956370-6	2021	Administration of a TRPV1 agonist, capsaicin, increases levels of phosphorylated p70S6K (p-p70S6K; activation of p70S6K) on astrocytes, resulting in the survival of dopamine neurons and behavioral recovery through endogenous production of CNTF in the MPP+ -lesioned rat model of PD.	Capsaicin	35-44	ribosomal protein S6 kinase B1	Rattus norvegicus	91-97
33493995-3	2021	Topical capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has been proposed in recent years as a low-cost and effective alternative to the traditional antiemetic regimen when treating CHS.	Capsaicin	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
33885140-0	2021	Retraction: Capsaicin inhibits migration and invasion via the AMPK/NF-kB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression.	Capsaicin	12-21	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	62-66
33885140-0	2021	Retraction: Capsaicin inhibits migration and invasion via the AMPK/NF-kB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression.	Capsaicin	12-21	matrix metallopeptidase 9	Homo sapiens	143-169
33927235-8	2021	Furthermore, immunohistochemical analyses of c-Fos expression induced by the capsaicin test revealed that neuronal activity of spinal cord neurons was suppressed by linalool odor exposure, which was prevented by intrathecal administration of the orexin 1 receptor antagonist.	Capsaicin	77-86	FBJ osteosarcoma oncogene	Mus musculus	45-50
33849430-5	2021	Mustard oil and capsaicin were used to stimulate TRPA1 and TRPV1 receptor channels.	Capsaicin	16-25	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	49-54
33986684-0	2021	Capsaicin protects cardiomyocytes against lipopolysaccharide-induced damage via 14-3-3gamma-mediated autophagy augmentation.	Capsaicin	0-9	tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma	Homo sapiens	80-91
33986684-2	2021	The changes in cardiomyocyte autophagy in sepsis and the effects and mechanism of action of capsaicin (Cap) remain unclear.	Capsaicin	92-101	sorbin and SH3 domain containing 1	Rattus norvegicus	103-106
33871648-8	2021	RESULTS: In STRIDE and PACE, respectively, n = 306/313 received capsaicin patch; n = 60/96 had a response after the first application, n = 33/68 after the second, n = 11/43 after the third.	Capsaicin	64-73	furin, paired basic amino acid cleaving enzyme	Homo sapiens	23-27
33937226-0	2021	Activation of TRPV1 by Capsaicin or Heat Drives Changes in 2-Acyl Glycerols and N-Acyl Ethanolamines in a Time, Dose, and Temperature Dependent Manner.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
33937226-2	2021	TRPV1, a calcium-permeable ion channel, is activated by capsaicin, elevated temperature, the eCB Anandamide, and over 15 additional endogenous lipids.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
33937226-4	2021	We recently found that activation of TRPV1-HEK cells by capsaicin increases the production of the eCB, 2-arachidonoyl glycerol (2-AG), suggesting a molecular link between these receptors.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
33937226-5	2021	Here, we tested the hypothesis that TRPV1 activation by capsaicin drives regulation of a wider-range of lipid signaling molecules and is time and dose-dependent.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-41
33849430-5	2021	Mustard oil and capsaicin were used to stimulate TRPA1 and TRPV1 receptor channels.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	59-64
33849430-7	2021	RESULTS: Pre-incubation with either petasin or isopetasin reduced mustard oil- and capsaicin-evoked CGRP release compared to vehicle in an approximately dose-dependent manner.	Capsaicin	83-92	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	100-104
33840300-12	2021	Furthermore, the CXCR2 antagonist SB225002 prevented trigeminal neuron sensitization to capsaicin induced by primed DPSC-CM.	Capsaicin	88-97	C-X-C motif chemokine receptor 2	Homo sapiens	17-22
33327798-2	2021	This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves.	Capsaicin	251-260	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-94
33837959-11	2021	LAMEA binds to the capsaicin-binding pocket of TRPV1.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
33327798-2	2021	This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves.	Capsaicin	251-260	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
33327798-2	2021	This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves.	Capsaicin	262-265	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-94
33327798-2	2021	This study tested the hypothesis that degeneration of transient receptor potential vanilloid 1 (TRPV1)-positive nerves exacerbates salt-induced hypertension and renal injury after I/R via enhancing renal macrophage infiltration.Methods: large dose of capsaicin (CAP, 100 mg/kg, subcutaneously) was used to degenerate rat TRPV1-positive nerves.	Capsaicin	262-265	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
33181192-2	2021	Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-76
33407019-12	2021	These results suggest that capsaicin or other therapeutic strategies to increase Ca2+ accumulation via TRPV1 might be more effective than hyperthermic therapy for Type I diabetic patients.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
32578137-3	2021	Expression level of TRPV1 cation channel is high in dorsal root ganglion (DRG), and its activation via capsaicin and reactive oxygen species (ROS) mediates peripheral neuropathic pain in mice.	Capsaicin	103-112	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-25
33641357-7	2021	Administration of capsaicin, TRPV1 agonist, in hindlimb evoked significantly greater increases in mean arterial pressure and renal sympathetic nerve activity in decerebrated T2D than control.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-34
33486334-5	2021	The capsaicin treatment increased the production of Th1 cytokines and decreased the production of Th2 cytokines and TGF-beta1 in the plasma and culture supernatants of immunosuppressed mice, which is associated with the modulation of Th2 induced by stress cells.	Capsaicin	4-13	transforming growth factor, beta 1	Mus musculus	116-125
33486334-9	2021	Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-beta1 through high doses of corticosterone, indicating direct cellular immunomodulation.	Capsaicin	18-27	interleukin 10	Mus musculus	65-70
33486334-9	2021	Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-beta1 through high doses of corticosterone, indicating direct cellular immunomodulation.	Capsaicin	18-27	interleukin 4	Mus musculus	72-76
33486334-9	2021	Intriguingly, the capsaicin treatment decreased the induction of IL-10, IL-4, and TGF-beta1 through high doses of corticosterone, indicating direct cellular immunomodulation.	Capsaicin	18-27	transforming growth factor, beta 1	Mus musculus	82-91
33181192-2	2021	Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	78-83
33181192-2	2021	Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain.	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-76
33181192-2	2021	Capsaicin selectively activates the transient receptor potential vanilloid 1 (TRPV1), which is enriched in nociceptive primary afferents, and underpins the mechanism for capsaicin-induced burning pain.	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	78-83
33181192-8	2021	By contrast, high concentrations of capsaicin lead to long-term defunctionalization mediated by the ablation of TRPV1-expressing afferent terminals, resulting in long-lasting analgesia persisting for several months.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
33113518-6	2021	Molecular docking studies against the identified targets in HepG2 cells showed that the capsaicin is able to bind Abelson tyrosine-protein kinase, c-Src kinase, p38 MAP kinase and VEGF-receptor.	Capsaicin	88-97	C-terminal Src kinase	Homo sapiens	114-159
33524482-5	2021	The serum levels of inflammatory cytokines and gastrointestinal hormones, and the localized inflammation and the expression of EGF, EGFR, VEGF, and ZO-1 in the gastrointestinal tissues in CAP-treated mice were partly restored by Qingke beta-glucan.	Capsaicin	188-191	epidermal growth factor	Mus musculus	127-130
33524482-5	2021	The serum levels of inflammatory cytokines and gastrointestinal hormones, and the localized inflammation and the expression of EGF, EGFR, VEGF, and ZO-1 in the gastrointestinal tissues in CAP-treated mice were partly restored by Qingke beta-glucan.	Capsaicin	188-191	epidermal growth factor receptor	Mus musculus	132-136
33524482-5	2021	The serum levels of inflammatory cytokines and gastrointestinal hormones, and the localized inflammation and the expression of EGF, EGFR, VEGF, and ZO-1 in the gastrointestinal tissues in CAP-treated mice were partly restored by Qingke beta-glucan.	Capsaicin	188-191	vascular endothelial growth factor A	Mus musculus	138-142
33524482-5	2021	The serum levels of inflammatory cytokines and gastrointestinal hormones, and the localized inflammation and the expression of EGF, EGFR, VEGF, and ZO-1 in the gastrointestinal tissues in CAP-treated mice were partly restored by Qingke beta-glucan.	Capsaicin	188-191	tight junction protein 1	Mus musculus	148-152
33347601-14	2021	The capsaicin-induced response in the presence of the GABA blocker in female rats was inhibited by intrathecal administration of 5-HT2 and 3 receptor antagonists but not by a D2-like dopamine receptor antagonist.	Capsaicin	4-13	5-hydroxytryptamine receptor 3A	Rattus norvegicus	129-149
33550097-2	2021	Transient receptor potential vanilloid 1 (TRPV1) is the specific receptor of capsaicin.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
33550097-2	2021	Transient receptor potential vanilloid 1 (TRPV1) is the specific receptor of capsaicin.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
33550097-4	2021	The aim of this study was to investigate the effects of capsaicin-activated TRPV1 on VSMC phenotypic switching.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
33550097-7	2021	Nevertheless, the data showed that capsaicin activated TRPV1 significantly decreased ox-LDL-induced superoxide anion generation.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-60
33550097-9	2021	Furthermore, capsaicin decreased ox-LDL-induced superoxide anion generation by activating peroxisome proliferator activated receptor alpha (PPARalpha).	Capsaicin	13-22	peroxisome proliferator activated receptor alpha	Homo sapiens	90-138
33550097-9	2021	Furthermore, capsaicin decreased ox-LDL-induced superoxide anion generation by activating peroxisome proliferator activated receptor alpha (PPARalpha).	Capsaicin	13-22	peroxisome proliferator activated receptor alpha	Homo sapiens	140-149
33752082-0	2021	Gating of the capsaicin receptor TRPV1 by UVA-light and oxidants are mediated by distinct mechanisms.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-38
33752082-2	2021	Oxidants and UVA-light activate TRPV2 by oxidizing methionine pore residues which are conserved in the capsaicin-receptor TRPV1.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 2	Homo sapiens	32-37
33752082-2	2021	Oxidants and UVA-light activate TRPV2 by oxidizing methionine pore residues which are conserved in the capsaicin-receptor TRPV1.	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-127
34012530-3	2021	Substance p which can be released following exposure to capsaicin is a TRPV1 inducer, shown to have altered concentration and function in mice with systemic lupus erythematosus (SLE).	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	71-76
32827294-1	2021	Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation of migraine pain.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-45
32827294-1	2021	Transient receptor potential vanilloid type 1 (TRPV1) receptors activated by heat and capsaicin are expressed in trigeminal nociceptive neurons and implicated in the generation of migraine pain.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
33113518-6	2021	Molecular docking studies against the identified targets in HepG2 cells showed that the capsaicin is able to bind Abelson tyrosine-protein kinase, c-Src kinase, p38 MAP kinase and VEGF-receptor.	Capsaicin	88-97	mitogen-activated protein kinase 14	Homo sapiens	161-175
33113518-8	2021	The IC50 of capsaicin loaded SLNs in HepG2 cells in vitro was 21.36 microg x mL-1.	Capsaicin	12-21	L1 cell adhesion molecule	Mus musculus	77-81
33668129-7	2021	Finally, both denervation and capsaicin treatment increased immunoexpression of proapoptotic protein Bax and inhibited HS-driven increase in antiapoptotic protein Bcl-2.	Capsaicin	30-39	BCL2 associated X, apoptosis regulator	Rattus norvegicus	101-104
33668129-7	2021	Finally, both denervation and capsaicin treatment increased immunoexpression of proapoptotic protein Bax and inhibited HS-driven increase in antiapoptotic protein Bcl-2.	Capsaicin	30-39	BCL2, apoptosis regulator	Rattus norvegicus	163-168
33508148-7	2021	Initial mechanistic studies indicated that membrane receptors, such as capsaicin receptor VR1/TRPV1, opioid receptors, and P2X3 receptors, might be involved.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	90-93
33546181-1	2021	Capsaicin is a potent agonist of the TRPV1 channel, a transduction channel that is highly expressed in nociceptive fibers (pain fibers) throughout the peripheral nervous system.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
33546181-6	2021	Capsaicin overcomes both liabilities by disrupting peripheral terminals of nociceptive fibers that express TRPV1, and thereby affects all of the potential means of activating that pain fiber (not just TRPV1 function).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
33546181-6	2021	Capsaicin overcomes both liabilities by disrupting peripheral terminals of nociceptive fibers that express TRPV1, and thereby affects all of the potential means of activating that pain fiber (not just TRPV1 function).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	201-206
33546181-9	2021	By disrupting the entire terminal of the TRPV1-expressing nociceptive fiber, capsaicin blocks all the activation mechanisms within that fiber, and not just TRPV1 function.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
33621204-5	2021	We also found that miR-23a was enriched in EVs released by cultured DRG neurons following capsaicin treatment.	Capsaicin	90-99	microRNA 23a	Mus musculus	19-26
33508148-7	2021	Initial mechanistic studies indicated that membrane receptors, such as capsaicin receptor VR1/TRPV1, opioid receptors, and P2X3 receptors, might be involved.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-99
33468207-7	2021	Immunoflorescent staining also showed that the histamine receptor H1 and the capsaicin receptor TRPV1 were significantly upregulated in DRG neurons.	Capsaicin	77-86	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	96-101
33128434-3	2021	Calcium peak stimulated by capsaicin, the ligand of TRPV1 channel, was decreased in neurons pre-irradiated with the combination of the two wavelengths.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-57
33280258-7	2021	Capsaicin and quercetin alone and combination with gemcitabine decreased the expression of ABCC2 and DCK and TKs, in T24-GCB cells.	Capsaicin	0-9	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	Mus musculus	91-96
33280258-7	2021	Capsaicin and quercetin alone and combination with gemcitabine decreased the expression of ABCC2 and DCK and TKs, in T24-GCB cells.	Capsaicin	0-9	deoxycytidine kinase	Mus musculus	101-104
33584270-5	2020	SMase (50 mU) or Myr (1 mM) pretreatment significantly decreased TRPV1 activation (capsaicin)-induced nocifensive eye-wiping movements by 37 and 41%, respectively.	Capsaicin	83-92	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
33184836-9	2021	Preconstriction of HAA with ET-1, but not high potassium buffer or phenylephrine, significantly potentiated capsaicin (0.1 muM)-induced constriction (33 +- 7 % vs 12 +- 8 %).	Capsaicin	108-117	endothelin 1	Homo sapiens	28-32
33184836-10	2021	GF109203X significantly inhibited potentiation of capsaicin-induced constriction by ET-1.	Capsaicin	50-59	endothelin 1	Homo sapiens	84-88
33089561-11	2021	The association of HPT and spiciness preferences correspond with the mutual activation of the tongue vanilloid receptors by noxious heat and capsaicin.	Capsaicin	141-150	HPT	Homo sapiens	19-22
33160235-6	2021	Obviously, the order of the sensitivity mediated by hTRPV1 was capsaicin > sanshool > allicin.	Capsaicin	63-72	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-58
33462325-0	2021	Dietary capsaicin normalizes CGRP peptidergic DRG neurons in experimental diabetic peripheral neuropathy.	Capsaicin	8-17	calcitonin-related polypeptide alpha	Rattus norvegicus	29-33
33462325-4	2021	We supplemented capsaicin in the diet of the animals to upregulate CGRP and reversed the downregulation of the neuropeptide in the dorsal root ganglion (DRG) neurons dissociated from the diabetic animals, via gene transfection and exogenous CGRP, to test disease-preventing and disease-limiting effects of CGRP.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
33462325-4	2021	We supplemented capsaicin in the diet of the animals to upregulate CGRP and reversed the downregulation of the neuropeptide in the dorsal root ganglion (DRG) neurons dissociated from the diabetic animals, via gene transfection and exogenous CGRP, to test disease-preventing and disease-limiting effects of CGRP.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	241-245
33462325-4	2021	We supplemented capsaicin in the diet of the animals to upregulate CGRP and reversed the downregulation of the neuropeptide in the dorsal root ganglion (DRG) neurons dissociated from the diabetic animals, via gene transfection and exogenous CGRP, to test disease-preventing and disease-limiting effects of CGRP.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	241-245
33462325-5	2021	Significant preservation of the nociceptive sensation, CGRP in spinal cord and DRG neurons, and number of CGRP-expressing neurons was found in the diabetic animals given capsaicin.	Capsaicin	170-179	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
33462325-5	2021	Significant preservation of the nociceptive sensation, CGRP in spinal cord and DRG neurons, and number of CGRP-expressing neurons was found in the diabetic animals given capsaicin.	Capsaicin	170-179	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
33462325-7	2021	The results suggest that downregulation of CGRP impairs viability, regeneration and function of peripheral sensory neurons while capsaicin normalizes the CGRP peptidergic DRG neurons and function of the sensory nerves.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	154-158
33449304-2	2021	Stimulating the oropharynx with capsaicin that mediates Substance P release is an emerging pharmacological treatment option which needs further scientific evidence.	Capsaicin	32-41	tachykinin precursor 1	Homo sapiens	56-67
33420359-0	2021	A capsaicinoid-based soft drug, AG1529, for attenuating TRPV1-mediated histaminergic and inflammatory sensory neuron excitability.	Capsaicin	2-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
33469265-0	2021	Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-kappaB Pathway.	Capsaicin	0-9	zinc finger and BTB domain containing 7A	Homo sapiens	91-96
33469265-0	2021	Capsaicin Inhibits Proliferation and Induces Apoptosis in Breast Cancer by Down-Regulating FBI-1-Mediated NF-kappaB Pathway.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	106-115
33469265-3	2021	However, whether FBI-1 is involved in capsaicin-induced breast cancer suppression has yet to be ascertained.	Capsaicin	38-47	zinc finger and BTB domain containing 7A	Homo sapiens	17-22
33469265-4	2021	This study aimed to investigate the effects of capsaicin on proliferation and apoptosis and its association with FBI-1 expression in breast cancer.	Capsaicin	47-56	zinc finger and BTB domain containing 7A	Homo sapiens	113-118
33469265-10	2021	Results: Capsaicin significantly inhibited proliferation and induced apoptosis in breast cancer in vitro and in vivo, along with decreased FBI-1, Ki-67, Bcl-2 and Survivin protein expression, increased Bax protein expression and activated Caspase 3.	Capsaicin	9-18	zinc finger and BTB domain containing 7a	Mus musculus	139-144
33469265-10	2021	Results: Capsaicin significantly inhibited proliferation and induced apoptosis in breast cancer in vitro and in vivo, along with decreased FBI-1, Ki-67, Bcl-2 and Survivin protein expression, increased Bax protein expression and activated Caspase 3.	Capsaicin	9-18	BCL2 apoptosis regulator	Homo sapiens	153-158
33469265-10	2021	Results: Capsaicin significantly inhibited proliferation and induced apoptosis in breast cancer in vitro and in vivo, along with decreased FBI-1, Ki-67, Bcl-2 and Survivin protein expression, increased Bax protein expression and activated Caspase 3.	Capsaicin	9-18	BCL2 associated X, apoptosis regulator	Homo sapiens	202-205
33469265-10	2021	Results: Capsaicin significantly inhibited proliferation and induced apoptosis in breast cancer in vitro and in vivo, along with decreased FBI-1, Ki-67, Bcl-2 and Survivin protein expression, increased Bax protein expression and activated Caspase 3.	Capsaicin	9-18	caspase 3	Homo sapiens	239-248
33469265-11	2021	Furthermore, FBI-1 overexpression obviously attenuated the capsaicin-induced anti-proliferation and pro-apoptosis effect, accompanied with the above-mentioned proteins reversed, whereas FBI-1 silencing generated exactly the opposite response.	Capsaicin	59-68	zinc finger and BTB domain containing 7a	Mus musculus	13-18
33469265-12	2021	In addition, as a target gene of FBI-1, NF-kappaB was inactivated by p65 nuclear translocation suppressed with capsaicin treatment, which was perceptibly weakened with FBI-1 overexpression or enhanced with FBI-1 silencing.	Capsaicin	111-120	zinc finger and BTB domain containing 7a	Mus musculus	33-38
33469265-12	2021	In addition, as a target gene of FBI-1, NF-kappaB was inactivated by p65 nuclear translocation suppressed with capsaicin treatment, which was perceptibly weakened with FBI-1 overexpression or enhanced with FBI-1 silencing.	Capsaicin	111-120	nuclear factor kappa B subunit 1	Homo sapiens	40-49
33469265-12	2021	In addition, as a target gene of FBI-1, NF-kappaB was inactivated by p65 nuclear translocation suppressed with capsaicin treatment, which was perceptibly weakened with FBI-1 overexpression or enhanced with FBI-1 silencing.	Capsaicin	111-120	RELA proto-oncogene, NF-kB subunit	Homo sapiens	69-72
33469265-12	2021	In addition, as a target gene of FBI-1, NF-kappaB was inactivated by p65 nuclear translocation suppressed with capsaicin treatment, which was perceptibly weakened with FBI-1 overexpression or enhanced with FBI-1 silencing.	Capsaicin	111-120	zinc finger and BTB domain containing 7a	Mus musculus	168-173
33469265-12	2021	In addition, as a target gene of FBI-1, NF-kappaB was inactivated by p65 nuclear translocation suppressed with capsaicin treatment, which was perceptibly weakened with FBI-1 overexpression or enhanced with FBI-1 silencing.	Capsaicin	111-120	zinc finger and BTB domain containing 7a	Mus musculus	168-173
33469265-13	2021	Conclusion: This study reveals that FBI-1 is closely involved in capsaicin-induced anti-proliferation and pro-apoptosis of breast cancer.	Capsaicin	65-74	zinc finger and BTB domain containing 7a	Mus musculus	36-41
33469265-15	2021	Targeting FBI-1 with capsaicin may be a promising therapeutic strategy in patients with breast cancer.	Capsaicin	21-30	zinc finger and BTB domain containing 7A	Homo sapiens	10-15
33420359-6	2021	We report that AG1529 competitively blocked capsaicin-evoked activation of hTRPV1 with micromolar potency, moderately affected pH-induced gating, and did not alter voltage- and heat-mediated responses.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-81
33420359-13	2021	Taken together, these preclinical results unveil the mode of action of AG1529 on TRPV1 channels and substantiate the tenet that this capsaicinoid-based soft drug is a promising candidate for drug development as a topical anti-pruritic and anti-inflammatory medication.	Capsaicin	133-145	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	81-86
32959171-5	2021	Furthermore, adult sensory neurons with DUSP knockdown were rendered sensitive to axonopathy in vitro following exposure to low, subtoxic TrpV1 (transient receptor potential cation channel subfamily V member 1) activation by capsaicin, an intervention normally supportive of growth.	Capsaicin	225-234	dual specificity phosphatase 5	Homo sapiens	40-44
33413604-3	2021	The most potent nutraceutical compound was capsaicin and it exerted its highest cytotoxicity against HCT 116 p53-/- with IC50 value of 19.67 +- 0.06 microM.	Capsaicin	43-52	tumor protein p53	Homo sapiens	109-112
33239169-3	2021	TRPV1 is known as a non-selective cation channels that respond to a wide range of physical and chemical stimuli such as high temperature, protons, capsaicin and so on.	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
33165872-1	2021	The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators.	Capsaicin	33-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
33165872-1	2021	The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators.	Capsaicin	148-157	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-44
33165872-1	2021	The transient receptor potential vanilloid-1 (TRPV1) is a non-specific cation channel known for its sensitivity to pungent vanilloid compound (i.e. capsaicin) and noxious stimuli, including heat, low pH or inflammatory mediators.	Capsaicin	148-157	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
33356266-1	2021	The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin.	Capsaicin	95-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	164-184
33356266-1	2021	The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin.	Capsaicin	95-104	acetylcholinesterase (Cartwright blood group)	Homo sapiens	186-190
33356266-1	2021	The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin.	Capsaicin	95-104	butyrylcholinesterase	Homo sapiens	196-217
33356266-1	2021	The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin.	Capsaicin	95-104	butyrylcholinesterase	Homo sapiens	219-223
33356266-1	2021	The combination of the scaffolds of the cholinesterase inhibitor huprine Y and the antioxidant capsaicin results in compounds with nanomolar potencies toward human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) that retain or improve the antioxidant properties of capsaicin.	Capsaicin	278-287	butyrylcholinesterase	Homo sapiens	40-54
33045060-6	2021	Additionally, oral capsaicin consumption, which can activate somatosensory nerves by binding to TRPV1, dramatically alleviated acute VOE and significantly prevented chronic liver and kidney damage in SCD mice.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	96-101
32886307-9	2021	In accordance, high-dose CPS treatment had discrete effects on gene expression in colon tumors, as only 3/94 (3.19%) genes were significantly modified (downregulation of Cebpd and Fasl, and upregulation of Jag1).	Capsaicin	25-28	CCAAT/enhancer binding protein delta	Rattus norvegicus	170-175
32886307-9	2021	In accordance, high-dose CPS treatment had discrete effects on gene expression in colon tumors, as only 3/94 (3.19%) genes were significantly modified (downregulation of Cebpd and Fasl, and upregulation of Jag1).	Capsaicin	25-28	Fas ligand	Rattus norvegicus	180-184
32886307-9	2021	In accordance, high-dose CPS treatment had discrete effects on gene expression in colon tumors, as only 3/94 (3.19%) genes were significantly modified (downregulation of Cebpd and Fasl, and upregulation of Jag1).	Capsaicin	25-28	jagged canonical Notch ligand 1	Rattus norvegicus	206-210
33179114-6	2021	Rutaecarpine, capsaicin and its derivatives, such as evodiamine, decrease gastric mucosal damage induced by several factors, including increased synthesis and release of CGRP.	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	170-174
32959171-5	2021	Furthermore, adult sensory neurons with DUSP knockdown were rendered sensitive to axonopathy in vitro following exposure to low, subtoxic TrpV1 (transient receptor potential cation channel subfamily V member 1) activation by capsaicin, an intervention normally supportive of growth.	Capsaicin	225-234	transient receptor potential cation channel subfamily V member 1	Homo sapiens	138-143
32959171-5	2021	Furthermore, adult sensory neurons with DUSP knockdown were rendered sensitive to axonopathy in vitro following exposure to low, subtoxic TrpV1 (transient receptor potential cation channel subfamily V member 1) activation by capsaicin, an intervention normally supportive of growth.	Capsaicin	225-234	transient receptor potential cation channel subfamily V member 1	Homo sapiens	145-209
33391007-7	2020	Although ablation of the whole TRPV1-expressing nerve population by high dose capsaicin, or more selectively by intersectional genetics, has allowed researchers to investigate the functions of capsaicin-sensitive afferents in health and disease, several "mysteries" remain unsolved to date, including the molecular underpinnings of "capsaicin desensitization," and the exact role these nerves play in thermoregulation and heat sensation.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
33719729-6	2021	We found that after intraplantar administration of the TrpV1 agonist, capsaicin, mice preferred to stay in cooler temperatures than saline injected mice.	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	55-60
32400193-9	2021	At the end of week 3, dietary 0.02% CPS attenuated DEN-induced oxidative damage and, consequently, hepatocyte necrosis by reducing serum alanine aminotransferase levels, liver CD68-positive macrophages, lipid peroxidation, while increasing antioxidant glutathione system.	Capsaicin	36-39	Cd68 molecule	Rattus norvegicus	176-180
32400193-10	2021	Additionally, 0.02% CPS upregulated vanilloid Trpv1 receptor and anti-inflammatory epoxygenase Cyp2j4 genes in the liver.	Capsaicin	20-23	cytochrome P450, family 2, subfamily j, polypeptide 4	Rattus norvegicus	95-101
32400193-11	2021	Ultimately, previous 0.02% CPS intake decreased the number of GST-P-positive preneoplastic lesions at week 12.	Capsaicin	27-30	glutathione S-transferase pi 1	Rattus norvegicus	62-67
32701656-8	2021	Thus, capsaicin morphed the descriptor pattern of the blade to become more capsaicin-like, which is probably explained best by peripheral sensitization of the TRPV1 receptor.	Capsaicin	6-15	transient receptor potential cation channel subfamily V member 1	Homo sapiens	159-164
32701656-8	2021	Thus, capsaicin morphed the descriptor pattern of the blade to become more capsaicin-like, which is probably explained best by peripheral sensitization of the TRPV1 receptor.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	159-164
33424555-6	2020	Perfusion of the TRPV1 agonist, capsaicin (1 muM), transiently increased the firing frequency in approximately 46-48% of the cold-sensitive nerves characterized by low-background activity and high threshold (LB-HT) cold thermoreceptors in both groups.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
33391007-7	2020	Although ablation of the whole TRPV1-expressing nerve population by high dose capsaicin, or more selectively by intersectional genetics, has allowed researchers to investigate the functions of capsaicin-sensitive afferents in health and disease, several "mysteries" remain unsolved to date, including the molecular underpinnings of "capsaicin desensitization," and the exact role these nerves play in thermoregulation and heat sensation.	Capsaicin	193-202	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
33391007-7	2020	Although ablation of the whole TRPV1-expressing nerve population by high dose capsaicin, or more selectively by intersectional genetics, has allowed researchers to investigate the functions of capsaicin-sensitive afferents in health and disease, several "mysteries" remain unsolved to date, including the molecular underpinnings of "capsaicin desensitization," and the exact role these nerves play in thermoregulation and heat sensation.	Capsaicin	193-202	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
33288188-1	2020	We aimed to investigate whether the sensitivity to capsaicin had an effect on pungency perception of pasta filata cheeses.	Capsaicin	51-60	solute carrier family 45 member 1	Homo sapiens	101-106
33376801-10	2020	Capsaicin and anandamide (AEA) activated TRPV1 receptors with an EC50 of 61 nM and 4.3 muM, respectively, but TRPV1 showed no response to Delta9-THC, cannabidiol, and other minor cannabinoids.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
32946866-5	2020	Similarly, ET1 strongly reduced paw licking response in the capsaicin test, the abdominal stretching in the writhing test and the carrageenan-induced thermal hyperalgesia.	Capsaicin	60-69	endothelin 1	Mus musculus	11-14
33272194-11	2020	CAP treatment deteriorated transient receptor potential vanilloid 1 (TRPV1)-positive neurons and increased caspase-3 signals in nodose ganglion (NG) neurons.	Capsaicin	0-3	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-67
33272194-11	2020	CAP treatment deteriorated transient receptor potential vanilloid 1 (TRPV1)-positive neurons and increased caspase-3 signals in nodose ganglion (NG) neurons.	Capsaicin	0-3	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-74
33272194-11	2020	CAP treatment deteriorated transient receptor potential vanilloid 1 (TRPV1)-positive neurons and increased caspase-3 signals in nodose ganglion (NG) neurons.	Capsaicin	0-3	caspase 3	Rattus norvegicus	107-116
32882205-9	2020	Ketamine also prevented TRPV1 receptor desensitization induced by successive applications of capsaicin.	Capsaicin	93-102	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
32882205-11	2020	Taken together, our data indicate that ketamine potentiates TRPV1 receptor sensitivity to capsaicin through a mechanism dependent on PKCie activity.	Capsaicin	90-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-65
33038582-1	2020	Capsaicin (N-vanillyl-8-methyl-alpha-nonenamide), a spicy, neurotoxic component of hot pepper is a ligand of vanilloid type-I (TRPV1) receptor of anti-cancer potential.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	127-132
33095918-9	2020	In rat DRG neurons, activin C enhanced capsaicin-induced TRPV1 currents.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
33287697-0	2020	Correction to: The knockdown of Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion.	Capsaicin	68-77	neuropeptide FF receptor 2	Mus musculus	32-58
33287697-0	2020	Correction to: The knockdown of Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion.	Capsaicin	68-77	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	86-90
33038582-6	2020	We found that capsaicin in a dose dependent manner induced expression of PPARgamma in glioblastoma LN-18 cells.	Capsaicin	14-23	peroxisome proliferator activated receptor gamma	Homo sapiens	73-82
33038582-7	2020	These findings suggest that capsaicin-dependent up-regulation of PPARgamma represent the mechanism for augmentation of cell death by thiazolidinediones.	Capsaicin	28-37	peroxisome proliferator activated receptor gamma	Homo sapiens	65-74
33010057-5	2020	Pre-treatment cells with IL-23 significantly reduced calcium responses to histamine and capsaicin but not chloroquine.	Capsaicin	88-97	interleukin 23, alpha subunit p19	Mus musculus	25-30
33288188-9	2020	In conclusion, sensitivity to capsaicin affected pungency perception in pasta filata cheese, whereas no clear relationship was observed between pungency perception and liking.	Capsaicin	30-39	solute carrier family 45 member 1	Homo sapiens	72-77
32944976-13	2020	Pharmacologic and/or genetic disruption of TRPV1 abolished all these effects of capsaicin as well as vasoconstriction triggered by lysophosphatidic acid, a bioactive lipid generated by platelets and atherogenic plaques.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	43-48
32811220-0	2020	Capsaicin attenuates liver fibrosis by targeting Notch signaling to inhibit TNF-alpha secretion from M1 macrophages.	Capsaicin	0-9	tumor necrosis factor	Mus musculus	76-85
32811220-7	2020	Capsaicin inhibited M1 polarization of macrophage by regulating Notch signaling leading to the reduced secretion of inflammatory cytokine TNF-alpha that correspondingly attenuates myofibroblasts regeneration and fibrosis formation of hepatocyte stellate cells (HSCs).	Capsaicin	0-9	tumor necrosis factor	Mus musculus	138-147
32811220-8	2020	CONCLUSION: Taken together, capsaicin alleviates liver fibrosis by inactivation of Notch signaling and further inhibiting TNF-alpha secretion from M1 macrophage.	Capsaicin	28-37	tumor necrosis factor	Mus musculus	122-131
32171536-12	2020	Modulatory effects of nesfatin-1 on microbiota and oxidative injury were partially reversed by capsaicin.	Capsaicin	95-104	nucleobindin 2	Rattus norvegicus	22-32
33173974-0	2020	Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/beta-catenin signaling pathway.	Capsaicin	0-9	cyclin dependent kinase 8	Homo sapiens	68-72
33173974-9	2020	In addition, capsaicin significantly reduced the expression of cyclin-dependent kinase 8 (CDK8) in breast cancer cells compared with the control group.	Capsaicin	13-22	cyclin dependent kinase 8	Homo sapiens	90-94
33173974-0	2020	Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/beta-catenin signaling pathway.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	78-81
33173974-11	2020	Furthermore, capsaicin significantly reduced the expression levels of phosphorylated (p)-PI3K, p-Akt, Wnt and beta-catenin in vitro compared with the control group.	Capsaicin	13-22	AKT serine/threonine kinase 1	Homo sapiens	97-100
33173974-0	2020	Capsaicin suppresses breast cancer cell viability by regulating the CDK8/PI3K/Akt/Wnt/beta-catenin signaling pathway.	Capsaicin	0-9	catenin beta 1	Homo sapiens	86-98
33173974-11	2020	Furthermore, capsaicin significantly reduced the expression levels of phosphorylated (p)-PI3K, p-Akt, Wnt and beta-catenin in vitro compared with the control group.	Capsaicin	13-22	catenin beta 1	Homo sapiens	110-122
33173974-9	2020	In addition, capsaicin significantly reduced the expression of cyclin-dependent kinase 8 (CDK8) in breast cancer cells compared with the control group.	Capsaicin	13-22	cyclin dependent kinase 8	Homo sapiens	63-88
33173974-12	2020	Collectively, the results of the present study suggested that capsaicin inhibited breast cancer cell viability, induced G2/M cell cycle arrest, reduced CDK8 expression levels, decreased the phosphorylation of PI3K and Akt and downregulated Wnt and beta-catenin expression levels in MDA-MB-231 cells.	Capsaicin	62-71	cyclin dependent kinase 8	Homo sapiens	152-156
33173974-12	2020	Collectively, the results of the present study suggested that capsaicin inhibited breast cancer cell viability, induced G2/M cell cycle arrest, reduced CDK8 expression levels, decreased the phosphorylation of PI3K and Akt and downregulated Wnt and beta-catenin expression levels in MDA-MB-231 cells.	Capsaicin	62-71	AKT serine/threonine kinase 1	Homo sapiens	218-221
32763303-0	2020	Capsaicin: TRPV1-independent mechanisms and novel therapeutic possibilities.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	11-16
33173974-12	2020	Collectively, the results of the present study suggested that capsaicin inhibited breast cancer cell viability, induced G2/M cell cycle arrest, reduced CDK8 expression levels, decreased the phosphorylation of PI3K and Akt and downregulated Wnt and beta-catenin expression levels in MDA-MB-231 cells.	Capsaicin	62-71	catenin beta 1	Homo sapiens	248-260
33070237-4	2020	Nephritis was induced by OX-7 antibodies in rats, 6 days later instrumented for recording of blood pressure (BP), heart rate (HR), drug administration, and intrarenal administration (IRA) of the TRPV1 agonist capsaicin to stimulate afferent renal nerve pathways containing SP and electrodes for renal sympathetic nerve activity (RSNA).	Capsaicin	209-218	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	195-200
32791143-2	2020	Sensitivity of TRPV1 to several stimuli is known to vary among species, specifically, the avian orthologue is nearly insensitive to capsaicin.	Capsaicin	132-141	transient receptor potential cation channel subfamily V member 1	Gallus gallus	15-20
33187307-6	2020	In agreement with these observations, TRPV1 protein was expressed and capsaicin, a selective TRPV1 agonist, induced Ca2+ influx by engaging both TRPV1 and NCX in mCRC cells.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-98
32791143-8	2020	Low [Na+]o synergistically potentiated the capsaicin- and proton-induced TRPV1 activation in cDRG neurons.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Gallus gallus	73-78
33187307-6	2020	In agreement with these observations, TRPV1 protein was expressed and capsaicin, a selective TRPV1 agonist, induced Ca2+ influx by engaging both TRPV1 and NCX in mCRC cells.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-98
33187307-6	2020	In agreement with these observations, TRPV1 protein was expressed and capsaicin, a selective TRPV1 agonist, induced Ca2+ influx by engaging both TRPV1 and NCX in mCRC cells.	Capsaicin	70-79	T cell leukemia homeobox 2	Homo sapiens	155-158
33164749-0	2020	New capsaicin analogs as molecular rulers to define the permissive conformation of the mouse TRPV1 ligand-binding pocket.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	93-98
33262985-8	2020	In contrast, TRPV1 was slightly activated in hCMEC/D3 cells as shown by the weak Ca2+ influx induced by capsaicin at a high concentration (3 muM), a highly potent and specific TRPV1 agonist.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
33262985-8	2020	In contrast, TRPV1 was slightly activated in hCMEC/D3 cells as shown by the weak Ca2+ influx induced by capsaicin at a high concentration (3 muM), a highly potent and specific TRPV1 agonist.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	176-181
33164749-6	2020	Our study suggests the existence of an optimal ligand-binding pocket conformation for capsaicin-mediated TRPV1 activation gating, and reveals multiple ligand-channel interactions that stabilize this permissive conformation.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	105-110
33020652-3	2020	In vivo imaging revealed that noxious stimulation by intraplantar capsaicin injection activated Hes5+ SDH astrocytes via alpha1A-adrenoceptors (alpha1A-ARs) through descending noradrenergic signaling from the locus coeruleus.	Capsaicin	66-75	hes family bHLH transcription factor 5	Homo sapiens	96-100
32771398-0	2020	Capsaicin induces mitochondrial dysfunction and apoptosis in anaplastic thyroid carcinoma cells via TRPV1-mediated mitochondrial calcium overload.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
32771398-5	2020	In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-95
32771398-5	2020	In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
32771398-5	2020	In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells.	Capsaicin	43-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-95
32771398-5	2020	In this study, we reported that capsaicin (CAP), a transient receptor potential vanilloid type1 (TRPV1) agonist, inhibited the viability of anaplastic thyroid cancer cells.	Capsaicin	43-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
32771398-6	2020	Capsaicin treatment triggered Ca2+ influx by TRPV1 activation, resulting in disequilibrium of intracellular calcium homeostasis.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-50
32771398-10	2020	It was worth noting that both TRPV1 antagonist (capsazepine) and calcium chelator (BAPTA) could attenuate aberrant Ca2+ homeostasis, mitochondrial dysfunction and apoptosis induced by capsaicin treatment.	Capsaicin	184-193	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-35
32771398-11	2020	Thus, our study demonstrated that capsaicin induced mitochondrial calcium overload and apoptosis in ATC cells through a TRPV1-mediated pathway.	Capsaicin	34-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-125
32040846-2	2020	Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se).	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
32040846-2	2020	Transient receptor potential vanilloid 1 (TRPV1) as a Ca2+ permeable cation channel is activated by capsaicin and reactive oxygen species (ROS), although it is blocked by capsazepine and sodium selenite (Na-Se).	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
33020652-5	2020	Furthermore, capsaicin-induced mechanical hypersensitivity was prevented by the inhibition of descending locus coeruleus-noradrenergic signaling onto Hes5+ astrocytes.	Capsaicin	13-22	hes family bHLH transcription factor 5	Homo sapiens	150-154
32910929-13	2020	Capsaicin significantly increased SP release from DRG cells, but a high concentration (1 mM) of the GABA receptor agonist muscimol, propofol, gaboxadol, or baclofen did not inhibit the capsaicin-induced SP release, suggesting that their antinociceptive effects were not through this mechanism.	Capsaicin	0-9	trefoil factor 2	Rattus norvegicus	34-36
32569089-8	2020	Behaviourally, Nhe6 KO mice have decreased nocifensive responses to acute noxious thermal, mechanical and chemical (i.e., capsaicin) stimuli.	Capsaicin	122-131	solute carrier family 9 (sodium/hydrogen exchanger), member 6	Mus musculus	15-19
32569089-9	2020	The reduced capsaicin-sensitivity in the KO mice correlates with a decreased expression of the transient receptor potential channel TRPV1 at the plasma membrane and capsaicin-induced Ca influx in primary cultures of nociceptors.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	132-137
32915316-6	2020	Inhibition of IL-1beta production with MCC950 in the PVN dose-dependently inhibited the capsaicin-induced ERR and sympathetic activation.	Capsaicin	88-97	interleukin 1 alpha	Rattus norvegicus	14-22
33016967-0	2020	Eugenol and capsaicin exhibit anti-metastatic activity via modulating TGF-beta signaling in gastric carcinoma.	Capsaicin	12-21	transforming growth factor alpha	Homo sapiens	70-78
32915316-7	2020	The PVN microinjection of IL-1 receptor antagonist IL-1Ra or specific IL-1beta antibody abolished the capsaicin-induced ERR, while IL-1beta enhanced the ERR.	Capsaicin	102-111	interleukin 1 receptor antagonist	Rattus norvegicus	51-57
32915316-7	2020	The PVN microinjection of IL-1 receptor antagonist IL-1Ra or specific IL-1beta antibody abolished the capsaicin-induced ERR, while IL-1beta enhanced the ERR.	Capsaicin	102-111	interleukin 1 alpha	Rattus norvegicus	70-78
32915316-8	2020	Renal infusion of capsaicin promoted p65-NFkappaB phosphorylation and IL-1beta production in the PVN, which were prevented by PVN microinjection of NADPH oxidase inhibitor apocynin or the superoxide anion scavenger tempol.	Capsaicin	18-27	synaptotagmin 1	Rattus norvegicus	37-40
32915316-8	2020	Renal infusion of capsaicin promoted p65-NFkappaB phosphorylation and IL-1beta production in the PVN, which were prevented by PVN microinjection of NADPH oxidase inhibitor apocynin or the superoxide anion scavenger tempol.	Capsaicin	18-27	interleukin 1 alpha	Rattus norvegicus	70-78
32915316-9	2020	The PVN microinjection of NFkappaB inhibitor BMS-345541 abolished the capsaicin induced-ERR and IL-1beta production, but not the NADPH oxidase activation and superoxide anion production.	Capsaicin	70-79	interleukin 1 alpha	Rattus norvegicus	96-104
32915316-10	2020	Furthermore, capsaicin-induced p65-NFkappaB phosphorylation and IL-1beta production in the PVN were prevented by AT1R antagonist losartan, or angiotensin converting enzyme inhibitor captopril.	Capsaicin	13-22	synaptotagmin 1	Rattus norvegicus	31-34
32915316-10	2020	Furthermore, capsaicin-induced p65-NFkappaB phosphorylation and IL-1beta production in the PVN were prevented by AT1R antagonist losartan, or angiotensin converting enzyme inhibitor captopril.	Capsaicin	13-22	interleukin 1 alpha	Rattus norvegicus	64-72
32915316-10	2020	Furthermore, capsaicin-induced p65-NFkappaB phosphorylation and IL-1beta production in the PVN were prevented by AT1R antagonist losartan, or angiotensin converting enzyme inhibitor captopril.	Capsaicin	13-22	angiotensin II receptor, type 1a	Rattus norvegicus	113-117
32915316-10	2020	Furthermore, capsaicin-induced p65-NFkappaB phosphorylation and IL-1beta production in the PVN were prevented by AT1R antagonist losartan, or angiotensin converting enzyme inhibitor captopril.	Capsaicin	13-22	angiotensin I converting enzyme	Rattus norvegicus	142-171
32915316-11	2020	These results indicate that capsaicin-induced ERR and sympathetic activation are mediated by IL-1beta in the PVN.	Capsaicin	28-37	interleukin 1 alpha	Rattus norvegicus	93-101
33016967-4	2020	However, unlike eugenol, the inhibitory effect of capsaicin on the TGF-beta signaling pathway and metastasis was found to be dependent on SMAD4, which was validated in SMAD4-knocked down AGS cell and SMAD4-null SW620 cell line.	Capsaicin	50-59	transforming growth factor alpha	Homo sapiens	67-75
33016967-4	2020	However, unlike eugenol, the inhibitory effect of capsaicin on the TGF-beta signaling pathway and metastasis was found to be dependent on SMAD4, which was validated in SMAD4-knocked down AGS cell and SMAD4-null SW620 cell line.	Capsaicin	50-59	SMAD family member 4	Homo sapiens	138-143
33016967-4	2020	However, unlike eugenol, the inhibitory effect of capsaicin on the TGF-beta signaling pathway and metastasis was found to be dependent on SMAD4, which was validated in SMAD4-knocked down AGS cell and SMAD4-null SW620 cell line.	Capsaicin	50-59	SMAD family member 4	Homo sapiens	168-173
33016967-4	2020	However, unlike eugenol, the inhibitory effect of capsaicin on the TGF-beta signaling pathway and metastasis was found to be dependent on SMAD4, which was validated in SMAD4-knocked down AGS cell and SMAD4-null SW620 cell line.	Capsaicin	50-59	SMAD family member 4	Homo sapiens	168-173
33204332-7	2020	Mechanistically, RvD3 inhibited capsaicin-induced TRPV1 currents in dissociated dorsal root ganglion (DRG) neurons via the N-formyl peptide receptor 2 (i.e. ALX/FPR2), a G-protein coupled receptor.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	50-55
33204332-7	2020	Mechanistically, RvD3 inhibited capsaicin-induced TRPV1 currents in dissociated dorsal root ganglion (DRG) neurons via the N-formyl peptide receptor 2 (i.e. ALX/FPR2), a G-protein coupled receptor.	Capsaicin	32-41	formyl peptide receptor 2	Homo sapiens	123-150
33204332-7	2020	Mechanistically, RvD3 inhibited capsaicin-induced TRPV1 currents in dissociated dorsal root ganglion (DRG) neurons via the N-formyl peptide receptor 2 (i.e. ALX/FPR2), a G-protein coupled receptor.	Capsaicin	32-41	hematopoietic SH2 domain containing	Homo sapiens	157-160
33204332-7	2020	Mechanistically, RvD3 inhibited capsaicin-induced TRPV1 currents in dissociated dorsal root ganglion (DRG) neurons via the N-formyl peptide receptor 2 (i.e. ALX/FPR2), a G-protein coupled receptor.	Capsaicin	32-41	formyl peptide receptor 2	Homo sapiens	161-165
33204332-10	2020	Finally, we elevated the translational potential of this study by showing that RvD3 significantly inhibited capsaicin-induced TRPV1 activity and CGRP release in human DRG neurons.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	126-131
32561277-7	2020	Our results indicate that only PPL presented antinociceptive induced by capsaicin, suggesting the potential clinical application of PPL as inhibitor of orofacial nociception and that this effect may be due to the modulation of TRPV1 channel.	Capsaicin	72-81	transient receptor potential cation channel, subfamily V, member 1	Danio rerio	227-232
32633621-0	2020	Intragastric administration of AMG517, a TRPV1 antagonist, enhanced activity-dependent energy metabolism via capsaicin-sensitive sensory nerves in mice.	Capsaicin	109-118	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	41-46
32833423-3	2020	Activation of transient receptor potential vanilloid subfamily 1 (TRPV1), a nonselective cation channel protein, by capsaicin, prevents KA-induced seizures in a mouse model of temporal lobe epilepsy.	Capsaicin	116-125	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-64
32833423-3	2020	Activation of transient receptor potential vanilloid subfamily 1 (TRPV1), a nonselective cation channel protein, by capsaicin, prevents KA-induced seizures in a mouse model of temporal lobe epilepsy.	Capsaicin	116-125	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	66-71
32833423-10	2020	Molecular modeling data revealed that KA binds to TRPV1 and prebinding with capsaicin prevents the binding of KA to TRPV1.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-121
32833423-11	2020	Consistently, the lack of effect of KA in activating chicken TRPV1, which is insensitive to capsaicin suggests that there is a significant overlap between the sites of KA and capsaicin activation of TRPV1.	Capsaicin	175-184	transient receptor potential cation channel subfamily V member 1	Gallus gallus	199-204
32562269-5	2020	KEY RESULTS: 4-AA reduced capsaicin-induced nociceptive behaviour in naive and inflamed conditions through the CB1 receptor.	Capsaicin	26-35	cannabinoid receptor 1	Homo sapiens	111-114
32889380-0	2020	Capsaicin: A "hot" KDM1A/LSD1 inhibitor from peppers.	Capsaicin	0-9	lysine demethylase 1A	Homo sapiens	19-24
32889380-0	2020	Capsaicin: A "hot" KDM1A/LSD1 inhibitor from peppers.	Capsaicin	0-9	lysine demethylase 1A	Homo sapiens	25-29
32562269-6	2020	4-AA (100 muM) reduced capsaicin-induced increase in [Ca2+ ]i in a CB1 receptor-dependent manner when PGE2 was not present.	Capsaicin	23-32	cannabinoid receptor 1	Homo sapiens	67-70
32889380-2	2020	In our study, capsaicin was characterized as lysine specific demethylase 1A (KDM1A/LSD1) inhibitor with IC50 of 0.6 +- 0.0421 muM in biochemical level, and can bind KDM1A recombinant directly and reversibly.	Capsaicin	14-23	lysine demethylase 1A	Homo sapiens	77-82
32721035-10	2020	Furthermore, both 25OHD and 1,25OHD can inhibit capsaicin-induced TRPV1 activity (IC50 =  34.3+-0.2 nM and IC50 =  11.5+-0.9 nM, respectively), but not pH-induced TRPV1 activity, suggesting that vitamin D interacts with TRPV1 in the same region as the TRPV1 agonist capsaicin.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	66-71
32889380-2	2020	In our study, capsaicin was characterized as lysine specific demethylase 1A (KDM1A/LSD1) inhibitor with IC50 of 0.6 +- 0.0421 muM in biochemical level, and can bind KDM1A recombinant directly and reversibly.	Capsaicin	14-23	lysine demethylase 1A	Homo sapiens	83-87
32889380-2	2020	In our study, capsaicin was characterized as lysine specific demethylase 1A (KDM1A/LSD1) inhibitor with IC50 of 0.6 +- 0.0421 muM in biochemical level, and can bind KDM1A recombinant directly and reversibly.	Capsaicin	14-23	lysine demethylase 1A	Homo sapiens	165-170
32889380-3	2020	Further cellular study confirmed that capsaicin can bind and inhibit KDM1A in gastric cancer cell line BGC-823 and further inhibit cell invasion and migration by reversing epithelial-mesenchymal transition (EMT).	Capsaicin	38-47	lysine demethylase 1A	Homo sapiens	69-74
32889380-4	2020	In sum, our findings identified KDM1A as a target of capsaicin and reveals capsaicin as a modifier of histone methylation for the first time, which may provide a new skeleton for further optimization of KDM1A inhibitor.	Capsaicin	53-62	lysine demethylase 1A	Homo sapiens	32-37
32889380-4	2020	In sum, our findings identified KDM1A as a target of capsaicin and reveals capsaicin as a modifier of histone methylation for the first time, which may provide a new skeleton for further optimization of KDM1A inhibitor.	Capsaicin	75-84	lysine demethylase 1A	Homo sapiens	203-208
32486909-5	2020	METHODS: In the current study, we used ELISA to investigate PACAP and calcitonin gene-related peptide release in response to 60 mM K+ or capsaicin using a rat hemi-skull model.	Capsaicin	137-146	adenylate cyclase activating polypeptide 1	Rattus norvegicus	60-65
32486909-5	2020	METHODS: In the current study, we used ELISA to investigate PACAP and calcitonin gene-related peptide release in response to 60 mM K+ or capsaicin using a rat hemi-skull model.	Capsaicin	137-146	calcitonin-related polypeptide alpha	Rattus norvegicus	70-101
32738201-1	2020	The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by inflammatory mediators and contributes to acute and chronic pain.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	36-41
32721035-10	2020	Furthermore, both 25OHD and 1,25OHD can inhibit capsaicin-induced TRPV1 activity (IC50 =  34.3+-0.2 nM and IC50 =  11.5+-0.9 nM, respectively), but not pH-induced TRPV1 activity, suggesting that vitamin D interacts with TRPV1 in the same region as the TRPV1 agonist capsaicin.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	163-168
32721035-10	2020	Furthermore, both 25OHD and 1,25OHD can inhibit capsaicin-induced TRPV1 activity (IC50 =  34.3+-0.2 nM and IC50 =  11.5+-0.9 nM, respectively), but not pH-induced TRPV1 activity, suggesting that vitamin D interacts with TRPV1 in the same region as the TRPV1 agonist capsaicin.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	163-168
32721035-10	2020	Furthermore, both 25OHD and 1,25OHD can inhibit capsaicin-induced TRPV1 activity (IC50 =  34.3+-0.2 nM and IC50 =  11.5+-0.9 nM, respectively), but not pH-induced TRPV1 activity, suggesting that vitamin D interacts with TRPV1 in the same region as the TRPV1 agonist capsaicin.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	163-168
32721035-11	2020	This hypothesis is supported by our in silico TRPV1 structural modelling studies, which place 25OHD in the same binding region as capsaicin.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
32453137-8	2020	A second application of capsaicin to the same eye had a lessened effect on tonic dopamine suggesting desensitization of TRPV1 channels in that eye.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
33077140-6	2020	For stimulation of TRPM8 ion channel, an application to the skin of 1% menthol was used, for TRPA1 - 0.04% allylisotiocianate, and for TRPV1 - capsaicin in a concentration of 0.001.The antigen binding in the spleen was two-times stimulated by activation of the cold-sensitive ion channel TRPM8 and much weaker by activation of warm-sensitive TRPV1 (by 15%), and another cold-sensitive ion channel TRPA1 (by 40%).	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	135-140
32651226-3	2020	The TRPV1 agonists capsaicin and piperine have been shown to increase salivary flow when introduced into the oral cavity but the sialogogic properties of other TRP channel agonists have not been investigated.	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
32712260-1	2020	PURPOSE: To evaluate transient receptor potential vanilloid 1 (TRPV1)-mediated pain sensitivity in patients with short tear break-up time (TBUT) dry eye (DE) by using the capsaicin stimulus test.	Capsaicin	171-180	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-61
32712260-1	2020	PURPOSE: To evaluate transient receptor potential vanilloid 1 (TRPV1)-mediated pain sensitivity in patients with short tear break-up time (TBUT) dry eye (DE) by using the capsaicin stimulus test.	Capsaicin	171-180	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
32721035-1	2020	KEY POINTS: 25OHD is a partial agonist of TRPV1 whereby 25OHD can weakly activate TRPV1 yet antagonize the stimulatory effects of the full TRPV1 agonists capsaicin and oleoyl dopamine.	Capsaicin	154-163	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
32574651-0	2020	Capsaicin-sensitive fibers mediate periorbital allodynia and activation of inflammatory cells after traumatic brain injury in rats: Involvement of TRPV1 channels in post-traumatic headache.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	147-152
32574651-4	2020	Thus, the involvement of fibers containing the transient receptor potential vanilloid 1 (TRPV1) channels on the PTH and inflammation after TBI through neonatal treatment with capsaicin are investigated.	Capsaicin	175-184	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	89-94
33101845-1	2020	While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel"s responses to each of these stimuli are profoundly regulated by membrane potential, damping or even prohibiting its response at negative voltages and amplifying its response at positive voltages.	Capsaicin	10-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
33040793-5	2020	Additionally, we examined the changes in both protein and mRNA levels of caspase-3 upon capsaicin exposure as well as conducted a series of experiments through which the relatively long term effect of capsaicin on the growth rate of the cells was assessed.	Capsaicin	88-97	caspase 3	Homo sapiens	73-82
33040793-7	2020	Moreover, along with the fact that capsaicin exposure did not have an impact on the cell growth in long term in most cases, caspase-3 levels also remained the same when exposed to capsaicin, suggesting a mechanism of cell death independent of caspases.	Capsaicin	180-189	caspase 3	Homo sapiens	124-133
33062722-4	2020	By contrast, treatment with capsaicin (a specific TRPV1 agonist) increased the survival of dopamine neurons in the SN and their fibers and dopamine levels in the STR in MPTP mice.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	50-55
33062722-6	2020	Treatment with AM251 and AM630 (CB1/2 antagonists) abolished capsaicin-induced beneficial effects, indicating the existence of a functional crosstalk between CB and TRPV1.	Capsaicin	61-70	cannabinoid receptor 1 (brain)	Mus musculus	32-37
33062722-6	2020	Treatment with AM251 and AM630 (CB1/2 antagonists) abolished capsaicin-induced beneficial effects, indicating the existence of a functional crosstalk between CB and TRPV1.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	165-170
33071817-5	2020	Both C1 and MCD significantly decreased the number of the TRPV1 activation (capsaicin)-induced nocifensive eye-wiping movements in the first hour by 45% and 32%, respectively, and C1 also in the second hour by 26%.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	58-63
33101845-1	2020	While the capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) channel is a polymodal nociceptor for heat, capsaicin, and protons, the channel"s responses to each of these stimuli are profoundly regulated by membrane potential, damping or even prohibiting its response at negative voltages and amplifying its response at positive voltages.	Capsaicin	122-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
32634675-8	2020	Our recordings also revealed that DPH partially blocked capsaicin evoked TRPV1 currents.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
32957493-5	2020	The activity profiles of catalase, total and isoenzymatic superoxide dismutase (SOD), the enzymes of the ascorbate-glutathione cycle (AGC) and four NADP-dehydrogenases indicate that some interaction with capsaicinoid metabolism seems to occur.	Capsaicin	204-216	catalase	Capsicum annuum	25-33
32957493-5	2020	The activity profiles of catalase, total and isoenzymatic superoxide dismutase (SOD), the enzymes of the ascorbate-glutathione cycle (AGC) and four NADP-dehydrogenases indicate that some interaction with capsaicinoid metabolism seems to occur.	Capsaicin	204-216	superoxide dismutase [Mn], mitochondrial	Capsicum annuum	58-78
32957493-5	2020	The activity profiles of catalase, total and isoenzymatic superoxide dismutase (SOD), the enzymes of the ascorbate-glutathione cycle (AGC) and four NADP-dehydrogenases indicate that some interaction with capsaicinoid metabolism seems to occur.	Capsaicin	204-216	superoxide dismutase [Mn], mitochondrial	Capsicum annuum	80-83
32938990-2	2020	We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variability (HRV), while also taking into account the influence of TRPV-1 polymorphisms (SNPs).	Capsaicin	133-142	kininogen 1	Homo sapiens	54-64
32938990-2	2020	We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variability (HRV), while also taking into account the influence of TRPV-1 polymorphisms (SNPs).	Capsaicin	133-142	kininogen 1	Homo sapiens	66-68
32938990-2	2020	We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variability (HRV), while also taking into account the influence of TRPV-1 polymorphisms (SNPs).	Capsaicin	144-147	kininogen 1	Homo sapiens	54-64
32938990-2	2020	We tested whether inhaled prostaglandin-E2 (PGE2) and bradykinin (BK) regulate TRPV-1 activity in vivo by changing cough response to capsaicin (CPS) and affecting heart rate variability (HRV), while also taking into account the influence of TRPV-1 polymorphisms (SNPs).	Capsaicin	144-147	kininogen 1	Homo sapiens	66-68
32140944-0	2020	Proton Pump Inhibitors Prevent Gastric Antral Ulcers Induced by NSAIDs via Activation of Capsaicin-Sensitive Afferent Nerves in Mice.	Capsaicin	89-98	ATPase, H+/K+ exchanging, gastric, alpha polypeptide	Mus musculus	0-11
32638638-5	2020	RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
32638638-5	2020	RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	212-217
32638638-5	2020	RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively.	Capsaicin	65-74	cannabinoid receptor 1	Rattus norvegicus	222-225
32638638-5	2020	RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively.	Capsaicin	76-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
32638638-5	2020	RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively.	Capsaicin	76-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	212-217
32638638-5	2020	RESULTS: The CB1 receptors antagonist NIDA, or the TRPV1 agonist capsaicin (CPS) in the ventromedial prefrontal cortex increased the conditioned emotional response expression, and these effects were prevented by TRPV1 and CB1 antagonism, respectively.	Capsaicin	76-79	cannabinoid receptor 1	Rattus norvegicus	222-225
32447096-13	2020	In addition, R-methanandamide and capsaicin (0.01 muM), a TRPV1 agonist, increased NO production via the PKA pathway.	Capsaicin	34-43	TRPV1	Bos taurus	58-63
32872656-1	2020	The aim of this work was to determine whether Capsaicin may exert a vascular regulation through the activation of CB1 and/or CB2 receptors causing vasorelaxation in the rat aorta.	Capsaicin	46-55	cannabinoid receptor 1	Rattus norvegicus	114-117
32532587-2	2020	Recent cryoelectron microscopy (cryo-EM) studies of TRPM8 have shown distinct structural features in its architecture and domain assembly compared with the capsaicin receptor TRP vanilloid member 1 (TRPV1).	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
32872656-1	2020	The aim of this work was to determine whether Capsaicin may exert a vascular regulation through the activation of CB1 and/or CB2 receptors causing vasorelaxation in the rat aorta.	Capsaicin	46-55	cannabinoid receptor 2	Rattus norvegicus	125-128
32872656-9	2020	In accordance to our results, Capsaicin-induced vasorelaxation of the rat aorta is neither dependent of TRPV1 or CB2 receptors, but rather it is strongly suggested that a tandem mechanism between inactivation of L-type calcium channels and the direct activation of CB1 receptors is involved.	Capsaicin	30-39	cannabinoid receptor 2	Rattus norvegicus	113-116
32872656-5	2020	In these experiments, we found that the inhibition of CB1 using AM281, decreases the vasorelaxant effect caused by Capsaicin.	Capsaicin	115-124	cannabinoid receptor 1	Rattus norvegicus	54-57
32872656-10	2020	These findings are supported by CB1 docking simulation which predicted a binding site on CB1 receptors for Capsaicin.	Capsaicin	107-116	cannabinoid receptor 1	Rattus norvegicus	32-35
32872656-9	2020	In accordance to our results, Capsaicin-induced vasorelaxation of the rat aorta is neither dependent of TRPV1 or CB2 receptors, but rather it is strongly suggested that a tandem mechanism between inactivation of L-type calcium channels and the direct activation of CB1 receptors is involved.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	104-109
32764237-2	2020	Understanding the protective mechanisms including the role of Transient Receptor Potential Ankyrin1 (TRPA1) and Vanilloid1 (TRPV1) channels localized on capsaicin-sensitive afferents and non-neuronal structures might identify novel therapeutic approaches.	Capsaicin	153-162	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	62-99
32820172-2	2020	The TRPV1 ion channel is a well-studied heat-sensing receptor that is also activated by vanilloid compounds, including capsaicin.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
32824721-3	2020	Activation of TRP channels (e.g., TRPM5) in taste receptors by food/chemicals (e.g., capsaicin) is essential in the acquisition of nutrients, which fuel metabolism, growth, and development.	Capsaicin	85-94	transient receptor potential cation channel subfamily M member 5	Homo sapiens	34-39
32785200-3	2020	Since the analgesic capsaicin (CAP) triggers opening of the TRPV1 receptor pore, its combination with LAs could result in better uptake and improved anesthesia.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-65
32785200-3	2020	Since the analgesic capsaicin (CAP) triggers opening of the TRPV1 receptor pore, its combination with LAs could result in better uptake and improved anesthesia.	Capsaicin	31-34	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-65
33029298-7	2020	Immunohistochemical analysis revealed the elevated level of adiponectin in liver tissue of the capsaicin-treated mice.	Capsaicin	95-104	adiponectin, C1Q and collagen domain containing	Mus musculus	60-71
32764237-2	2020	Understanding the protective mechanisms including the role of Transient Receptor Potential Ankyrin1 (TRPA1) and Vanilloid1 (TRPV1) channels localized on capsaicin-sensitive afferents and non-neuronal structures might identify novel therapeutic approaches.	Capsaicin	153-162	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	101-106
32764237-2	2020	Understanding the protective mechanisms including the role of Transient Receptor Potential Ankyrin1 (TRPA1) and Vanilloid1 (TRPV1) channels localized on capsaicin-sensitive afferents and non-neuronal structures might identify novel therapeutic approaches.	Capsaicin	153-162	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	124-129
32753716-4	2020	Between 30-32  C, SEAP production was strongly potentiated 3.3-fold by the addition of the TRPV1 agonist capsaicin.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	91-96
32406099-7	2020	Additionally, we demonstrate that intra-arterial infusion of capsaicin results in a dose related rise in MAP and HR that is significantly reduced by a selective and potent TRPV1 antagonist or completely abolished in Trpv1 null mice.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	172-177
32511032-7	2020	It is important to note that, as the mechanism of action of capsaicin 8% is the "defunctionalization" of small afferent fibers through interaction with TRPV1 receptors, the peripheral expression of this receptor on nociceptor fibers, is crucial to predict patient"s response to treatment.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	152-157
32474210-7	2020	Intra-RVM microinjection of orexin-A significantly prevented capsaicin-induced anxiety-like behavior and increased locomotor activity in the EPM and OF tests.	Capsaicin	61-70	hypocretin neuropeptide precursor	Rattus norvegicus	28-36
32474210-9	2020	Furthermore, orexin-A significantly increased p-ERK levels in capsaicin-treated rats.	Capsaicin	62-71	hypocretin neuropeptide precursor	Rattus norvegicus	13-21
32474210-9	2020	Furthermore, orexin-A significantly increased p-ERK levels in capsaicin-treated rats.	Capsaicin	62-71	Eph receptor B1	Rattus norvegicus	48-51
32406099-7	2020	Additionally, we demonstrate that intra-arterial infusion of capsaicin results in a dose related rise in MAP and HR that is significantly reduced by a selective and potent TRPV1 antagonist or completely abolished in Trpv1 null mice.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	216-221
32418082-8	2020	Additionally, we identified the capsaicin target, the C. elegans transient receptor potential channel OCR-2 and not OSM-9.	Capsaicin	32-41	Ion_trans domain-containing protein	Caenorhabditis elegans	102-107
32994681-3	2020	We report the molecular binding features of capsaicin with apoptotic proteins such as Bcl-xl, Bcl-2 and Mcl-1 for further consideration.	Capsaicin	44-53	BCL2 like 1	Homo sapiens	86-92
32614062-0	2020	Expression of Concern: Capsaicin inhibits migration and invasion via the AMPK/NF-kB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression.	Capsaicin	23-32	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	73-77
32614062-0	2020	Expression of Concern: Capsaicin inhibits migration and invasion via the AMPK/NF-kB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression.	Capsaicin	23-32	matrix metallopeptidase 9	Homo sapiens	154-180
32994681-3	2020	We report the molecular binding features of capsaicin with apoptotic proteins such as Bcl-xl, Bcl-2 and Mcl-1 for further consideration.	Capsaicin	44-53	BCL2 apoptosis regulator	Homo sapiens	94-99
32994681-3	2020	We report the molecular binding features of capsaicin with apoptotic proteins such as Bcl-xl, Bcl-2 and Mcl-1 for further consideration.	Capsaicin	44-53	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	104-109
32708653-5	2020	We provided evidence that resolvins inhibited neuropeptide release from the stimulated sensory nerve terminals by TRPV1 and TRPA1 activators capsaicin (CAPS) and allyl-isothiocyanate (AITC), respectively.	Capsaicin	141-150	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	124-129
32708653-5	2020	We provided evidence that resolvins inhibited neuropeptide release from the stimulated sensory nerve terminals by TRPV1 and TRPA1 activators capsaicin (CAPS) and allyl-isothiocyanate (AITC), respectively.	Capsaicin	152-156	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	124-129
32661266-0	2020	Capsaicin consumption reduces brain amyloid-beta generation and attenuates Alzheimer"s disease-type pathology and cognitive deficits in APP/PS1 mice.	Capsaicin	0-9	presenilin 1	Mus musculus	140-143
32760273-0	2020	Novel TRPV1 Channel Agonists With Faster and More Potent Analgesic Properties Than Capsaicin.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	6-11
32760273-2	2020	Activated by capsaicin, heat, voltage and protons, it is also well known for its desensitization, which led to the medical use of topically applied TRPV1 agonist capsaicin for its long-lasting analgesic effects.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	148-153
32760273-2	2020	Activated by capsaicin, heat, voltage and protons, it is also well known for its desensitization, which led to the medical use of topically applied TRPV1 agonist capsaicin for its long-lasting analgesic effects.	Capsaicin	162-171	transient receptor potential cation channel subfamily V member 1	Homo sapiens	148-153
32661266-4	2020	We previously reported that capsaicin-rich diet consumption was associated with better cognition and lower serum Amyloid-beta (Abeta) levels in people aged 40 years and over.	Capsaicin	28-37	amyloid beta precursor protein	Homo sapiens	127-132
32661266-5	2020	In the present study, we found that intake of capsaicin, the pungent ingredient in chili peppers, reduced brain Abeta burden and rescued cognitive decline in APP/PS1 mice.	Capsaicin	46-55	amyloid beta (A4) precursor protein	Mus musculus	112-117
32661266-5	2020	In the present study, we found that intake of capsaicin, the pungent ingredient in chili peppers, reduced brain Abeta burden and rescued cognitive decline in APP/PS1 mice.	Capsaicin	46-55	presenilin 1	Mus musculus	162-165
32661266-6	2020	Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards alpha-cleavage and precluded Abeta generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10).	Capsaicin	47-56	amyloid beta (A4) precursor protein	Mus musculus	65-90
32661266-6	2020	Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards alpha-cleavage and precluded Abeta generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10).	Capsaicin	47-56	amyloid beta (A4) precursor protein	Mus musculus	145-150
32661266-6	2020	Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards alpha-cleavage and precluded Abeta generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10).	Capsaicin	47-56	a disintegrin and metallopeptidase domain 10	Mus musculus	193-231
32661266-6	2020	Our in vivo and in vitro studies revealed that capsaicin shifted Amyloid precursor protein (APP) processing towards alpha-cleavage and precluded Abeta generation by promoting the maturation of a disintegrin and metalloproteinase 10 (ADAM10).	Capsaicin	47-56	a disintegrin and metallopeptidase domain 10	Mus musculus	233-239
32640973-0	2020	Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion.	Capsaicin	36-45	neuropeptide FF receptor 2	Mus musculus	0-26
32623788-11	2022	Using neonatal capsaicin treatment, we identified that DOR agonist-induced thermal antinociception was mediated via receptors expressed on primary afferent sensory neurons but did not alter mechanical thresholds.	Capsaicin	15-24	opioid receptor, delta 1	Mus musculus	55-58
32685762-2	2020	Hypertonic stimulation modulates glutamatergic inputs to the supraoptic nucleus (SON) magnocellular neurosecretory cells (MNCs) putative vasopressin (VP) neurons through capsaicin-insensitive transient receptor potential vanilloid (TRPV) 1 channels on the presynaptic terminals.	Capsaicin	170-179	arginine vasopressin	Rattus norvegicus	137-148
32640973-0	2020	Neuropeptide FF receptor 2 inhibits capsaicin-induced CGRP Upregulation in mouse trigeminal ganglion.	Capsaicin	36-45	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	54-58
32640973-5	2020	Here, we investigate the impact of NPFFR2 on trigeminal CGRP level in a capsaicin-induced headache mouse model.	Capsaicin	72-81	neuropeptide FF receptor 2	Mus musculus	35-41
32640973-7	2020	Mice pretreated with Npffr2-shRNA or NPFFR2 knockouts were adopted to test the impact of NPFFR2 on capsaicin-induced CGRP upregulation in trigeminal ganglion.	Capsaicin	99-108	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	117-121
32640973-11	2020	FINDINGS: Infusion of capsaicin into the cisterna magna upregulated the CGRP in trigeminal ganglion and induced spontaneous pain behaviors including the reduction of locomotor activity and the increase of freezing behavior.	Capsaicin	22-31	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	72-76
32640973-13	2020	Mice pretreatment with Npffr2-shRNA prevented capsaicin-induced CGRP upregulation in trigeminal ganglion.	Capsaicin	46-55	neuropeptide FF receptor 2	Mus musculus	23-29
32640973-13	2020	Mice pretreatment with Npffr2-shRNA prevented capsaicin-induced CGRP upregulation in trigeminal ganglion.	Capsaicin	46-55	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	64-68
32640973-16	2020	CONCLUSIONS: Reducing the level of NPFFR2 leads to the downregulation of capsaicin-induced CGRP in trigeminal ganglion, which would consequently attenuate the activation of trigeminovascular pathway.	Capsaicin	73-82	neuropeptide FF receptor 2	Mus musculus	35-41
32640973-16	2020	CONCLUSIONS: Reducing the level of NPFFR2 leads to the downregulation of capsaicin-induced CGRP in trigeminal ganglion, which would consequently attenuate the activation of trigeminovascular pathway.	Capsaicin	73-82	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	91-95
32685028-0	2020	Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharyngeal Carcinoma.	Capsaicin	54-63	mitogen-activated protein kinase kinase 3	Homo sapiens	35-39
32236974-9	2020	The role of TRPV1 in the anti-inflammatory effects of SIRT6 was determined through incubation of SIRT6-expressing dental pulp stem cells (DPSCs) with capsaicin.	Capsaicin	150-159	sirtuin 6	Homo sapiens	54-59
32236974-9	2020	The role of TRPV1 in the anti-inflammatory effects of SIRT6 was determined through incubation of SIRT6-expressing dental pulp stem cells (DPSCs) with capsaicin.	Capsaicin	150-159	sirtuin 6	Homo sapiens	97-102
32706079-9	2020	RESULTS: In vitro, capsaicin upregulated the expression of nNOS, which was dose-dependently reversed by melatonin pretreatment (p < 0.001).	Capsaicin	19-28	nitric oxide synthase 1	Rattus norvegicus	59-63
32083340-8	2020	Importantly, capsaicin (TRPV-1 agonists) obviously reversed the pain-relieving effect of PF, suggesting the involvement of TRPV-1 in the analgesic activity of PF.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	24-30
32083340-8	2020	Importantly, capsaicin (TRPV-1 agonists) obviously reversed the pain-relieving effect of PF, suggesting the involvement of TRPV-1 in the analgesic activity of PF.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	123-129
32366601-10	2020	SIGNIFICANCE STATEMENT: alpha-Calcitonin gene-related peptide blockade by ALD403 was assessed via radiolabeled ligand displacement, in vitro inhibition of cell signaling, and in vivo inhibition of capsaicin-induced vasodilation.	Capsaicin	197-206	calcitonin related polypeptide alpha	Homo sapiens	30-61
32537633-0	2020	Regulation of Actg1 and Gsta2 is possible mechanism by which capsaicin alleviates apoptosis in cell model of 6-OHDA-induced Parkinson"s disease.	Capsaicin	61-70	actin, gamma 1	Rattus norvegicus	14-19
32537633-0	2020	Regulation of Actg1 and Gsta2 is possible mechanism by which capsaicin alleviates apoptosis in cell model of 6-OHDA-induced Parkinson"s disease.	Capsaicin	61-70	glutathione S-transferase alpha 2	Rattus norvegicus	24-29
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	olfactory receptor 724	Rattus norvegicus	144-150
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	152-156
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	glutathione S-transferase alpha 2	Rattus norvegicus	158-163
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	RAB5A, member RAS oncogene family	Rattus norvegicus	165-170
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	POTE ankyrin domain family, member F	Rattus norvegicus	172-177
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	actin, gamma 1	Rattus norvegicus	179-184
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	acyl-CoA dehydrogenase, short/branched chain	Rattus norvegicus	190-196
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	actin, gamma 1	Rattus norvegicus	207-212
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	actin, gamma 1	Rattus norvegicus	213-226
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	glutathione S-transferase alpha 2	Rattus norvegicus	250-255
32537633-3	2020	A total of 108 genes were differentially expressed in response to capsaicin treatment, and 7 of these genes were selected for further analysis: Olr724, COX1, Gsta2, Rab5a, Potef, Actg1, and Acadsb, of which Actg1(Actin gamma 1) was downregulated and Gsta2 (Glutathione S-transferase alpha 2) was upregulated.	Capsaicin	66-75	glutathione S-transferase alpha 2	Rattus norvegicus	257-290
32537633-7	2020	Capsaicin can protect the cells and reduce the apoptosis rate by regulating Actg1 and Gsta2.	Capsaicin	0-9	actin, gamma 1	Rattus norvegicus	76-81
32537633-7	2020	Capsaicin can protect the cells and reduce the apoptosis rate by regulating Actg1 and Gsta2.	Capsaicin	0-9	glutathione S-transferase alpha 2	Rattus norvegicus	86-91
32685028-0	2020	Therapeutic potential of targeting MKK3-p38 axis with Capsaicin for Nasopharyngeal Carcinoma.	Capsaicin	54-63	mitogen-activated protein kinase 14	Homo sapiens	40-43
32685028-4	2020	Co-immunoprecipitation, western blotting and pull-down assays were used to determine the effects of capsaicin on the MKK3-p38 axis.	Capsaicin	100-109	mitogen-activated protein kinase kinase 3	Mus musculus	117-121
32586044-2	2020	Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-96
32586044-2	2020	Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	98-103
32685028-4	2020	Co-immunoprecipitation, western blotting and pull-down assays were used to determine the effects of capsaicin on the MKK3-p38 axis.	Capsaicin	100-109	mitogen-activated protein kinase 14	Homo sapiens	122-125
32586044-2	2020	Activation of capsaicin-sensitive sensory nerves by the transient receptor potential vanilloid 1 (TRPV1) capsaicin receptor and other receptors, as well as neuropeptide mediators released from them upon stimulation, play important physiological regulatory roles.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-123
32685028-8	2020	Then we found that capsaicin directly targets p38 for dephosphorylation.	Capsaicin	19-28	mitogen-activated protein kinase 14	Homo sapiens	46-49
32685028-9	2020	As such, MKK3-induced p38 activation was inhibited by capsaicin.	Capsaicin	54-63	mitogen-activated protein kinase kinase 3	Homo sapiens	9-13
32685028-9	2020	As such, MKK3-induced p38 activation was inhibited by capsaicin.	Capsaicin	54-63	mitogen-activated protein kinase 14	Homo sapiens	22-25
32685028-11	2020	Xenograft models demonstrated the inhibitory effects of capsaicin treatment on NPC tumor growth in vivo, and analysis of clinical NPC samples confirmed that MKK3 phosphorylation was associated with NPC tumor growth and lymphoid node metastasis.	Capsaicin	56-65	mitogen-activated protein kinase kinase 3	Homo sapiens	157-161
32685028-12	2020	Conclusions: The MKK3-p38 axis represents a potential therapeutic target for capsaicin.	Capsaicin	77-86	mitogen-activated protein kinase kinase 3	Homo sapiens	17-21
32685028-12	2020	Conclusions: The MKK3-p38 axis represents a potential therapeutic target for capsaicin.	Capsaicin	77-86	mitogen-activated protein kinase 14	Homo sapiens	22-25
32685028-13	2020	MKK3 phosphorylation might serve as a biomarker to identify NPC patients most likely to benefit from adjunctive capsaicin treatment.	Capsaicin	112-121	mitogen-activated protein kinase kinase 3	Homo sapiens	0-4
32595512-10	2020	Overall, our results indicate different firing patterns evoked by inflammatory mediators and capsaicin via TRPV1 that correlate with the respective subsequent pain sensation.	Capsaicin	93-102	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	107-112
32345612-1	2020	The transient receptor potential vanilloid 1 (TRPV1) channel is activated by heat and by capsaicin, the pungent compound in chili peppers.	Capsaicin	89-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
31482758-2	2020	Standard antiemetic therapy is often ineffective; however, capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1), has shown promise in treating CHS.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	84-124
32526913-1	2020	The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein.	Capsaicin	79-88	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	4-42
32526913-1	2020	The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein.	Capsaicin	79-88	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	44-49
32526913-1	2020	The Transient Receptor Potential Ankyrin 1 (TRPA1) cation channel expressed on capsaicin-sensitive afferents, immune and endothelial cells is activated by inflammatory mediators and exogenous irritants, e.g., endotoxins, nicotine, crotonaldehyde and acrolein.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	51-65
32514053-1	2020	The vanilloid capsaicin is a widely consumed spice, known for its burning and "hot" sensation through activation of TRPV1 ion-channels, but also known to decrease oxidative stress, inflammation and influence tau-pathology.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-121
32514053-3	2020	Treatment of neuroblastoma cells with capsaicinoids (24 hours, 10 microM) resulted in enhanced Abeta-production and reduced Abeta-degradation, leading to increased Abeta-levels.	Capsaicin	38-51	amyloid beta precursor protein	Homo sapiens	95-100
32514053-3	2020	Treatment of neuroblastoma cells with capsaicinoids (24 hours, 10 microM) resulted in enhanced Abeta-production and reduced Abeta-degradation, leading to increased Abeta-levels.	Capsaicin	38-51	amyloid beta precursor protein	Homo sapiens	124-129
32514053-3	2020	Treatment of neuroblastoma cells with capsaicinoids (24 hours, 10 microM) resulted in enhanced Abeta-production and reduced Abeta-degradation, leading to increased Abeta-levels.	Capsaicin	38-51	amyloid beta precursor protein	Homo sapiens	124-129
31482758-2	2020	Standard antiemetic therapy is often ineffective; however, capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1), has shown promise in treating CHS.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	126-131
32375895-0	2020	Immunomodulatory and anti-oxidative effect of the direct TRPV1 receptor agonist capsaicin on Schwann cells.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
32274951-1	2020	Background: Defense personnel utilize capsaicin based ocular sprays as non-lethal agents for law implementation during instances of mob violence.	Capsaicin	38-47	sphingomyelin synthase 1	Homo sapiens	132-135
31977939-7	2020	Dorsal root ganglion (DRG) neurons from Nav1.7 loss-of-function rats, although hypo-excitable compared to WT neurons, were still able to generate action potentials in response to noxious heat and capsaicin.	Capsaicin	196-205	sodium voltage-gated channel alpha subunit 9	Rattus norvegicus	40-46
31518162-13	2020	Conclusion: Dietary capsaicin may alleviate 2K1C renovascular hypertension, probably via enhancing phosphorylation of Akt and eNOS.	Capsaicin	20-29	AKT serine/threonine kinase 1	Rattus norvegicus	118-121
32404326-0	2020	Ablation of TRPV1+ afferent terminals by capsaicin mediates long-lasting analgesia for trigeminal neuropathic pain.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	12-17
32404326-2	2020	Capsaicin is a pungent ingredient of chili peppers and specifically activates transient receptor potential vanilloid subtype 1 (TRPV1), a Ca2+-permeable ion channel.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	128-133
32404326-13	2020	These results suggest that a single focal injection of capsaicin induces long-lasting analgesia for neuropathic pain via selective ablation of TRPV1+ afferent terminals and that TRPV1+ afferents contribute to the maintenance of trigeminal neuropathic pain.Significance Statement Capsaicin has long been used as an analgesic to treat chronic pain conditions.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	143-148
32404326-13	2020	These results suggest that a single focal injection of capsaicin induces long-lasting analgesia for neuropathic pain via selective ablation of TRPV1+ afferent terminals and that TRPV1+ afferents contribute to the maintenance of trigeminal neuropathic pain.Significance Statement Capsaicin has long been used as an analgesic to treat chronic pain conditions.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	178-183
32404326-17	2020	We found that a single focal injection of capsaicin to facial skin robustly attenuated trigeminal neuropathic pain in mice for longer than two weeks, which is mediated by localized ablation of TRPV1+ terminals in the skin.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	193-198
32097658-10	2020	To investigate whether a potential tension-dependent CGRP-induced dilation of veins caused the decline between the two IC/IC100 peaks, a second study was performed, with the CGRP receptor antagonist, BIBN4096BS (olcegepant) and the sensory nerve secretagogue, capsaicin.	Capsaicin	260-269	calcitonin-related polypeptide alpha	Rattus norvegicus	53-57
32375895-8	2020	RESULTS: In SC monoculture, incubation with capsaicin significantly reduces interferon gamma-induced MHC-II production as well as toll-like receptor 4 and intercellular adhesion molecule 1 mRNA expression.	Capsaicin	44-53	interferon gamma	Rattus norvegicus	76-92
32375895-8	2020	RESULTS: In SC monoculture, incubation with capsaicin significantly reduces interferon gamma-induced MHC-II production as well as toll-like receptor 4 and intercellular adhesion molecule 1 mRNA expression.	Capsaicin	44-53	toll-like receptor 4	Rattus norvegicus	130-150
32375895-8	2020	RESULTS: In SC monoculture, incubation with capsaicin significantly reduces interferon gamma-induced MHC-II production as well as toll-like receptor 4 and intercellular adhesion molecule 1 mRNA expression.	Capsaicin	44-53	intercellular adhesion molecule 1	Rattus norvegicus	155-188
32528827-5	2020	Capsaicin inhibits LASV entry by blocking the pH dependent viral fusion through affecting the stable signal peptide (SSP)-GP2 transmembrane (GP2TM) region of the LASV surface glycoprotein.	Capsaicin	0-9	glycoprotein 2	Homo sapiens	122-125
32415171-0	2020	A single TRPV1 amino acid controls species sensitivity to capsaicin.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Gallus gallus	9-14
32415171-1	2020	Chili peppers produce capsaicin (a vanilloid) that activates the transient receptor potential cation channel subfamily V member 1 (TRPV1) on sensory neurons to alter their membrane potential and induce pain.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Gallus gallus	65-129
32415171-1	2020	Chili peppers produce capsaicin (a vanilloid) that activates the transient receptor potential cation channel subfamily V member 1 (TRPV1) on sensory neurons to alter their membrane potential and induce pain.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Gallus gallus	131-136
32415171-2	2020	To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	189-194
32415171-2	2020	To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids.	Capsaicin	165-174	transient receptor potential cation channel subfamily V member 1	Gallus gallus	189-194
32415171-2	2020	To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	189-194
32415171-2	2020	To identify residues responsible for differential TRPV1 capsaicin sensitivity among species, we used intracellular Ca2+ imaging to characterize chimeras composed of capsaicin-sensitive rat TRPV1 (rTRPV1) and capsaicin-insensitive chicken TRPV1 (cTRPV1) exposed to a series of capsaicinoids.	Capsaicin	165-174	transient receptor potential cation channel subfamily V member 1	Gallus gallus	189-194
32415171-5	2020	Similarly, replacing corresponding rTRPV1 residue E570 with lysine or glutamine retained capsaicin sensitivity.	Capsaicin	89-98	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-41
32415171-8	2020	Our study demonstrates that a subtle modification of TRPV1 in different species globally alters capsaicin responses.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Gallus gallus	53-58
31821012-2	2020	The aim of this study was to investigate the role of capsaicin-sensitive afferent neurons and vagus in the effect of apelin against ischemia/reperfusion (I/R) injury.	Capsaicin	53-62	apelin	Homo sapiens	117-123
32293931-5	2020	The TRPV1 agonist capsaicin caused a transient HP increase in WT lenses that peaked after ~30 min then returned toward baseline.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-9
32293931-10	2020	Bumetanide, A889425 and the Akt inhibitor Akti prevented the Rb+ uptake response to capsaicin.	Capsaicin	84-93	thymoma viral proto-oncogene 1	Mus musculus	28-31
32293931-12	2020	Capsaicin also elicited rapid (<2 min) NKCC1 phosphorylation in WT but not TRPV1-/- cells.	Capsaicin	0-9	solute carrier family 12, member 2	Mus musculus	39-44
32293931-15	2020	Taken together, responses to capsaicin and hyperosmotic solution point to a functional role for TRPV1 channels in mouse lens.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	96-101
32293932-9	2020	Moreover, the expression of TRPV1 was induced under hypoxic stress, and its upregulation by capsaicin improved the autophagy flux and protected cardiomyocytes from hypoxic damage, whereas the silencing of TRPV1 significantly attenuated autophagy.	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-33
32302492-8	2020	ASIC 3 KO rats demonstrated lower pressor responses to intra-arterial injection of diprotonated phosphate (86mM; pH6.0), lactic acid (12mM; pH2.85), and capsaicin (0.2mug; pH7.2) (p< 0.05).	Capsaicin	153-162	acid sensing ion channel subunit 3	Rattus norvegicus	0-6
31821012-12	2020	Vagotomy, capsaicin, and lorglumide largely eliminated the gastroprotective effects of apelin-13.	Capsaicin	10-19	apelin	Homo sapiens	87-93
32371130-0	2020	Probing temperature and capsaicin-induced activation of TRPV1 channel via computationally guided point mutations in its pore and TRP domains.	Capsaicin	24-33	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
32036609-12	2020	GSH and PON-1 activity increased after capsaicin, phenytoin or capsaicin/phenytoin.	Capsaicin	39-48	paraoxonase 1	Rattus norvegicus	8-13
32377171-8	2020	Furthermore, we found that administration of the TRPV1 agonist capsaicin (Cap) reversed the effects of Dex on proinflammatory cytokines; however, the expression and activation of PKA-STAT3 and PKC-NF-kappaB signals were not altered owing to Cap administration.	Capsaicin	63-72	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
32377171-8	2020	Furthermore, we found that administration of the TRPV1 agonist capsaicin (Cap) reversed the effects of Dex on proinflammatory cytokines; however, the expression and activation of PKA-STAT3 and PKC-NF-kappaB signals were not altered owing to Cap administration.	Capsaicin	63-72	signal transducer and activator of transcription 3	Homo sapiens	183-188
32377171-8	2020	Furthermore, we found that administration of the TRPV1 agonist capsaicin (Cap) reversed the effects of Dex on proinflammatory cytokines; however, the expression and activation of PKA-STAT3 and PKC-NF-kappaB signals were not altered owing to Cap administration.	Capsaicin	63-72	proline rich transmembrane protein 2	Homo sapiens	193-196
32377171-8	2020	Furthermore, we found that administration of the TRPV1 agonist capsaicin (Cap) reversed the effects of Dex on proinflammatory cytokines; however, the expression and activation of PKA-STAT3 and PKC-NF-kappaB signals were not altered owing to Cap administration.	Capsaicin	63-72	nuclear factor kappa B subunit 1	Homo sapiens	197-206
32151541-0	2020	Tacrolimus, a calcineurin inhibitor, promotes capsaicin-induced colonic pain in mice.	Capsaicin	46-55	calcineurin binding protein 1	Mus musculus	14-35
32151541-3	2020	Intracolonic administration of capsaicin, a TRPV1 agonist, caused referred hyperalgesia in the lower abdomen, an effect prevented by capsazepine, a TRPV1 blocker.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	44-49
32151541-3	2020	Intracolonic administration of capsaicin, a TRPV1 agonist, caused referred hyperalgesia in the lower abdomen, an effect prevented by capsazepine, a TRPV1 blocker.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	148-153
32036609-12	2020	GSH and PON-1 activity increased after capsaicin, phenytoin or capsaicin/phenytoin.	Capsaicin	63-72	paraoxonase 1	Rattus norvegicus	8-13
32365623-0	2020	Changes in TRPV1-Mediated Physiological Function in Rats Systemically Treated With Capsaicin on the Neonate.	Capsaicin	83-92	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	11-16
31989424-7	2020	Blockade of angiotensin type 1 receptors with losartan or inhibition of angiotensin-converting enzyme with captopril in the PVN abolished the capsaicin-induced ERR.	Capsaicin	142-151	angiotensin I converting enzyme	Rattus norvegicus	72-101
31917773-10	2020	However, the EREG mAb prolonged allodynia when administered during the development of CFA-induced mechanosensitivity and enhanced pain behavior in the capsaicin model of acute pain.	Capsaicin	151-160	epiregulin	Mus musculus	13-17
32981275-1	2020	Objective: To observe whether the mechanism of small dose capsaicin (Cap) against pulmonary fibrosis in mouse is mediated by agitating transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	135-175
32981275-1	2020	Objective: To observe whether the mechanism of small dose capsaicin (Cap) against pulmonary fibrosis in mouse is mediated by agitating transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	177-182
32365623-2	2020	The transient receptor potential vanilloid 1 (TRPV1) is the capsaicin receptor channels that are involved in a variety of functions like transduction and transmission of the physiological stimulus.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-44
32365623-2	2020	The transient receptor potential vanilloid 1 (TRPV1) is the capsaicin receptor channels that are involved in a variety of functions like transduction and transmission of the physiological stimulus.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	46-51
32365623-3	2020	Subcutaneous injection of capsaicin to a newborn rat leads to involuntary lifelong TRPV1 desensitization.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
32365623-4	2020	Various physiological changes including sensory and homeostatic actions in the body associated with neonatal capsaicin treatment are induced by direct TRPV1 channel targeting.	Capsaicin	109-118	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	151-156
32290081-0	2020	Lipid Nanoparticle Inclusion Prevents Capsaicin-Induced TRPV1 Defunctionalization.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	56-61
32388008-5	2020	Liquiritin inhibited capsaicin- and allyl isothiocyanate-evoked TRPV1 and TRPA1 whole-cell currents, respectively, with a similar potency and maximal inhibition.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	64-69
32388008-5	2020	Liquiritin inhibited capsaicin- and allyl isothiocyanate-evoked TRPV1 and TRPA1 whole-cell currents, respectively, with a similar potency and maximal inhibition.	Capsaicin	21-30	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	74-79
32345727-4	2020	Simultaneous optical monitoring of CaCC activity and Ca2+ dynamics revealed that the TRPV1 ligand capsaicin activated CaCCs.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	85-90
32345727-5	2020	However, depletion of endoplasmic reticulum (ER) Ca2+ stores reduced capsaicin-induced Ca2+ increases and CaCC activation, suggesting that ER Ca2+ release contributed to TRPV1-induced CaCC activation.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	170-175
32316463-8	2020	Using calcium imaging, we observed that a proportion of cells responded to histamine, SLIGKV (a specific agonist of PAR2), polygodial (a specific agonist of TRPA1), and capsaicin (a specific agonist of TRPV1).	Capsaicin	169-178	transient receptor potential cation channel subfamily V member 1	Homo sapiens	202-207
32290081-1	2020	BACKGROUND: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-110
32290081-1	2020	BACKGROUND: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	112-117
32290081-1	2020	BACKGROUND: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity.	Capsaicin	23-26	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-110
32290081-1	2020	BACKGROUND: Capsaicin (CPS) is a highly selective agonist of the transient receptor potential vanilloid type 1 (TRPV1) with a nanomolar affinity.	Capsaicin	23-26	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	112-117
32290081-2	2020	High doses or prolonged exposure to CPS induces TRPV1 defunctionalization and, although this effect is currently used for the treatment of thermal hyperalgesia in chronic pain conditions, it is responsible of detrimental effects, such as denervation of sensory fibers.	Capsaicin	36-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	48-53
32290081-3	2020	The aim of the present study was to formulate CPS loaded lipid nanocarriers (CPS-LN) in order to optimize CPS release, thus preventing TRPV1 internalization and degradation.	Capsaicin	46-49	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	135-140
32290081-3	2020	The aim of the present study was to formulate CPS loaded lipid nanocarriers (CPS-LN) in order to optimize CPS release, thus preventing TRPV1 internalization and degradation.	Capsaicin	77-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	135-140
32290081-6	2020	Moreover, the expression of TRPV1 in the skin was evaluated by western blot analysis in CPS-LN injected mice and then compared to a standard CPS solution (CPS-STD).	Capsaicin	88-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-33
32290081-6	2020	Moreover, the expression of TRPV1 in the skin was evaluated by western blot analysis in CPS-LN injected mice and then compared to a standard CPS solution (CPS-STD).	Capsaicin	141-144	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-33
32290081-6	2020	Moreover, the expression of TRPV1 in the skin was evaluated by western blot analysis in CPS-LN injected mice and then compared to a standard CPS solution (CPS-STD).	Capsaicin	141-144	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-33
32290081-7	2020	RESULTS: CPS inclusion in LN induced a lower pain response when compared to CPS-STD; further, it prevented TRPV1 down-regulation in the skin, while CPS-STD induced a significant reduction of TRPV1 expression.	Capsaicin	9-12	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
32290081-7	2020	RESULTS: CPS inclusion in LN induced a lower pain response when compared to CPS-STD; further, it prevented TRPV1 down-regulation in the skin, while CPS-STD induced a significant reduction of TRPV1 expression.	Capsaicin	9-12	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	191-196
32061660-3	2020	Here, we report that dietary capsaicin potently inhibits and reverses chronic renal structural and functional damages in db/db or streptozotocin (STZ)-induced diabetic mice in a TRPV1-dependent manner.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	178-183
32337274-8	2020	Capsaicin, a TRPV1 agonist, delivery aggravated the performance of SE rats.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
32337274-13	2020	Interestingly, all these effects of Dex were partially counteracted by the TRPV1 agonist, capsaicin (P < 0.05).	Capsaicin	90-99	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	75-80
31876363-1	2020	BACKGROUND: This study investigated 1) if a prolonged noxious stimulus (24-hr topical capsaicin) in healthy adults would impair central pain inhibitory and facilitatory systems measured as a reduction in conditioned pain modulation (CPM) and enhancement of temporal summation of pain (TSP) and 2) if acute pain relief or exacerbation (cooling and heating the capsaicin patch) during the prolonged noxious stimulus would affect central pain modulation.	Capsaicin	86-95	thrombospondin 1	Homo sapiens	257-295
32061660-4	2020	Activation of TRPV1 by capsaicin alleviated hyperglycemia-induced mitochondrial dysfunction in podocytes, accompanied by reduced mitochondria-associated membranes (MAMs) formation and fewer Ca2+ transport from endoplasmic reticulum (ER) to mitochondria.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
32061660-6	2020	Inhibition of AMPK or overexpression of Fundc1 obviously blocked the inhibitory effect of capsaicin on MAMs formation and functional decline in podocytes.	Capsaicin	90-99	FUN14 domain containing 1	Mus musculus	40-46
31782192-0	2020	Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/beta-catenin pathway.	Capsaicin	0-9	Wnt family member 2	Homo sapiens	77-80
31782192-0	2020	Capsaicin suppressed activity of prostate cancer stem cells by inhibition of Wnt/beta-catenin pathway.	Capsaicin	0-9	catenin beta 1	Homo sapiens	81-93
31926897-2	2020	TRPV1 can be activated by capsaicin (CAP), protons (low pH), and heat.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	Wnt family member 2	Homo sapiens	57-62
31926897-2	2020	TRPV1 can be activated by capsaicin (CAP), protons (low pH), and heat.	Capsaicin	37-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	glycogen synthase kinase 3 alpha	Homo sapiens	66-74
31926897-4	2020	Second-generation (mode-selective) TRPV1 antagonists potently block channel activation by CAP, but exert different effects (e.g., potentiation, no effect, or low-potency inhibition) in the proton mode, heat mode, or both.	Capsaicin	90-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-40
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	catenin beta 1	Homo sapiens	79-91
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	Wnt family member 2	Homo sapiens	57-60
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	catenin beta 1	Homo sapiens	126-138
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	160-165
31782192-4	2020	Further, we found capsaicin suppressed the expression of Wnt-2, p-GSK3beta and beta-catenin, along with downregulation of Wnt/beta-catenin pathway target genes c-myc and cyclinD1.	Capsaicin	18-27	cyclin D1	Homo sapiens	170-178
31782192-5	2020	Using LiCl, a activator of Wnt/beta-catenin pathway, we found activation of Wnt/beta-catenin pathway could ameliorate the downregulation of prostate CSCs markers and the growth inhibition induced by capsaicin in prostate cancer stem cells.	Capsaicin	199-208	Wnt family member 2	Homo sapiens	27-30
31782192-5	2020	Using LiCl, a activator of Wnt/beta-catenin pathway, we found activation of Wnt/beta-catenin pathway could ameliorate the downregulation of prostate CSCs markers and the growth inhibition induced by capsaicin in prostate cancer stem cells.	Capsaicin	199-208	catenin beta 1	Homo sapiens	31-43
31782192-5	2020	Using LiCl, a activator of Wnt/beta-catenin pathway, we found activation of Wnt/beta-catenin pathway could ameliorate the downregulation of prostate CSCs markers and the growth inhibition induced by capsaicin in prostate cancer stem cells.	Capsaicin	199-208	Wnt family member 2	Homo sapiens	76-79
31782192-5	2020	Using LiCl, a activator of Wnt/beta-catenin pathway, we found activation of Wnt/beta-catenin pathway could ameliorate the downregulation of prostate CSCs markers and the growth inhibition induced by capsaicin in prostate cancer stem cells.	Capsaicin	199-208	catenin beta 1	Homo sapiens	80-92
31782192-6	2020	Those data suggested that the inhibition effect of capsaicin on prostate cancer stem cells and the anti-cancer effect of capsaicin on prostate cancer stem cell may be mediated by Wnt/beta-catenin pathway.	Capsaicin	51-60	Wnt family member 2	Homo sapiens	179-182
31782192-6	2020	Those data suggested that the inhibition effect of capsaicin on prostate cancer stem cells and the anti-cancer effect of capsaicin on prostate cancer stem cell may be mediated by Wnt/beta-catenin pathway.	Capsaicin	51-60	catenin beta 1	Homo sapiens	183-195
31782192-6	2020	Those data suggested that the inhibition effect of capsaicin on prostate cancer stem cells and the anti-cancer effect of capsaicin on prostate cancer stem cell may be mediated by Wnt/beta-catenin pathway.	Capsaicin	121-130	Wnt family member 2	Homo sapiens	179-182
31782192-6	2020	Those data suggested that the inhibition effect of capsaicin on prostate cancer stem cells and the anti-cancer effect of capsaicin on prostate cancer stem cell may be mediated by Wnt/beta-catenin pathway.	Capsaicin	121-130	catenin beta 1	Homo sapiens	183-195
32078575-4	2020	Using Ca2+ imaging, we further investigated in neurons the effects of gabapentinoids upon stimulation with the TRPV-1 agonist capsaicin.	Capsaicin	126-135	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	111-117
32245175-2	2020	The capsaicin and heat sensor TRPV1, and the menthol and cold sensor TRPM8, have been shown to be modulated by the membrane protein PIRT (Phosphoinositide-interacting regulator of TRP).	Capsaicin	4-13	phosphoinositide interacting regulator of transient receptor potential channels	Homo sapiens	132-136
32086614-11	2020	In addition, stimulating either iWAT or retroperitoneal WAT with capsaicin increased TNF-alpha or IL-1beta levels in the PVN, but the injection of capsaicin into the jugular vein, skeletal muscle, and skin had no effects on TNF-alpha or IL-1beta levels in the PVN.	Capsaicin	65-74	tumor necrosis factor	Rattus norvegicus	85-94
32086614-11	2020	In addition, stimulating either iWAT or retroperitoneal WAT with capsaicin increased TNF-alpha or IL-1beta levels in the PVN, but the injection of capsaicin into the jugular vein, skeletal muscle, and skin had no effects on TNF-alpha or IL-1beta levels in the PVN.	Capsaicin	65-74	interleukin 1 alpha	Rattus norvegicus	98-106
32086614-11	2020	In addition, stimulating either iWAT or retroperitoneal WAT with capsaicin increased TNF-alpha or IL-1beta levels in the PVN, but the injection of capsaicin into the jugular vein, skeletal muscle, and skin had no effects on TNF-alpha or IL-1beta levels in the PVN.	Capsaicin	65-74	tumor necrosis factor	Rattus norvegicus	224-233
32086614-11	2020	In addition, stimulating either iWAT or retroperitoneal WAT with capsaicin increased TNF-alpha or IL-1beta levels in the PVN, but the injection of capsaicin into the jugular vein, skeletal muscle, and skin had no effects on TNF-alpha or IL-1beta levels in the PVN.	Capsaicin	65-74	interleukin 1 alpha	Rattus norvegicus	237-245
31757360-2	2020	TRPV1 can be activated by low extracellular pH, high temperature, or naturally occurring pungent molecules such as allicin, capsaicin, or resiniferatoxin.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
31935455-0	2020	Multiple single nucleotide polymorphisms of the transient receptor potential vanilloid 1 (TRPV1) genes associate with cough sensitivity to capsaicin in healthy subjects.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	90-95
31935455-3	2020	Capsaicin (CPS) activates TRPV1 and is regularly used as a tool to study cough response.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-31
31935455-3	2020	Capsaicin (CPS) activates TRPV1 and is regularly used as a tool to study cough response.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-31
31935455-4	2020	Although single nucleotide polymorphisms (SNPs) of TRPV1 are implicated in CPS binding, their role in cough response is not fully elucidated.	Capsaicin	75-78	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
31935455-5	2020	AIMS: In this study we investigated the relationship between capsaicin cough challenge sensitivity and multiple TRPV1 polymorphisms.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
31935455-8	2020	The association between combinations of TRPV1 SNPs and CPS sensitivity of each subject was assessed by linear regression.	Capsaicin	55-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
31935455-12	2020	CONCLUSION: Capsaicin cough challenge sensitivity in healthy subjects is dependent on multiple TRPV1 polymorphisms.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
32061032-8	2020	Furthermore, pharmacological activation of TRPV1 by capsaicin (1 mg/kg, i.p.	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
31981911-11	2020	Furthermore, this alkaloid reduces the capsaicin- and cinnamaldehyde-mediated Ca2+ influx, indicating a possible modulation of TRPV1 and TRPA1 channels, respectively.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	127-132
31981911-11	2020	Furthermore, this alkaloid reduces the capsaicin- and cinnamaldehyde-mediated Ca2+ influx, indicating a possible modulation of TRPV1 and TRPA1 channels, respectively.	Capsaicin	39-48	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	137-142
31796207-3	2020	In an effort to elucidate whether modulatory effect of dexmedetomidine on TRPV1 activity could be the potential peripheral mechanism underlying the antinociceptive effect of dexmedetomidine, intracellular calcium concentration after capsaicin application was investigated in mice dorsal root ganglion (DRG) neurons, with and without pretreatment of dexmedetomidine.	Capsaicin	233-242	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	74-79
31669938-8	2020	Immunofluorescence results showed that treatment with quercetin (Qc), catechin (Cat) and capsaicin (Cap) induced the translocation of Nrf2 into the nucleus, at the same level as did H2O2 treatment, thus mimicking the action of the endogenous cell response to peroxidation.	Capsaicin	89-98	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
32149229-3	2020	The addition of a nonlethal dose of ionomycin to HeLa and capsaicin to TRPV1-expressing HEK293 cells resulted in a sudden change in the magnetic field signal consistent with Ca2+ influx, which was also observed by confocal fluorescence microscopy under the same conditions.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
32149229-4	2020	In contrast, addition of capsaicin to TRPV1-expressing HEK293 cells containing an optimum amount of a TRPV1 antagonist (ruthenium red), resulted in no detectable magnetic or fluorescent signals.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	38-43
32149229-4	2020	In contrast, addition of capsaicin to TRPV1-expressing HEK293 cells containing an optimum amount of a TRPV1 antagonist (ruthenium red), resulted in no detectable magnetic or fluorescent signals.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
32180694-1	2020	Background: Capsaicin (CAP) has an anti-obesity effect that has been shown to involve the transient receptor potential vanilloid-1 (TRPV1) channel.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	90-130
32180694-1	2020	Background: Capsaicin (CAP) has an anti-obesity effect that has been shown to involve the transient receptor potential vanilloid-1 (TRPV1) channel.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	132-137
32180694-1	2020	Background: Capsaicin (CAP) has an anti-obesity effect that has been shown to involve the transient receptor potential vanilloid-1 (TRPV1) channel.	Capsaicin	23-26	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	90-130
32180694-1	2020	Background: Capsaicin (CAP) has an anti-obesity effect that has been shown to involve the transient receptor potential vanilloid-1 (TRPV1) channel.	Capsaicin	23-26	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	132-137
31669938-8	2020	Immunofluorescence results showed that treatment with quercetin (Qc), catechin (Cat) and capsaicin (Cap) induced the translocation of Nrf2 into the nucleus, at the same level as did H2O2 treatment, thus mimicking the action of the endogenous cell response to peroxidation.	Capsaicin	100-103	NFE2 like bZIP transcription factor 2	Rattus norvegicus	134-138
31883821-4	2020	We observed that, compared to wildtype, pkr2-null mice were more resistant to nociceptive sensitization to temperatures ranging from 46 to 48 C, to capsaicin and to protons, highlighting a positive interaction between PKR2 and the non-selective cation channels TRPV1.	Capsaicin	148-157	prokineticin receptor 2	Mus musculus	40-44
32054058-1	2020	Dual antifouling and antibacterial polysulfone(PSf)/polyethersulfone(PES) hybrid membranes were developed by the synergy of capsaicin-mimic N-(5-methyl acrylamide-2,3,4 hydroxy benzyl) acrylamide (AMTHBA) and vinyl triethylene (b-methoxy ethoxy) silane (VTMES).	Capsaicin	124-133	insulin like growth factor binding protein 7	Homo sapiens	47-50
32039693-9	2020	These results indicate that a Cap-induced decrease in the LV contractility, like in cases of hyperthermia, are due to the down-regulation of the total calcium handling in E-C coupling, suggesting that negative inotropic effect in hyperthermia-heart is, at least in part, mediated through TRPV1 signaling pathway.	Capsaicin	30-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	288-293
32116530-0	2020	Effects of TRPV1 Activation by Capsaicin and Endogenous N-Arachidonoyl Taurine on Synaptic Transmission in the Prefrontal Cortex.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	11-16
32116530-4	2020	Here we show in mice that activation of TRPV1-, by the exogenous agonist capsaicin-, regulates synaptic activity in both glutamatergic and GABAergic synaptic transmission.	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-45
32116530-5	2020	Moreover, activation by the endogenous activator N-arachidonoyl taurine (NAT), induced similar effects as capsaicin.	Capsaicin	106-115	solute carrier family 38, member 3	Mus musculus	49-71
32116530-5	2020	Moreover, activation by the endogenous activator N-arachidonoyl taurine (NAT), induced similar effects as capsaicin.	Capsaicin	106-115	solute carrier family 38, member 3	Mus musculus	73-76
32033346-7	2020	The expression and activities of glutamic acid synthetase (GOGAT) and glutamine synthetase (GS) that are involved in ammonium assimilation were affected by adjusting the ammonium-N proportion, and they were significantly positively correlated with capsaicin, dihydrocapsaicin contents, capsaicinoid synthetase (CS), as well as the relative expression levels of genes related to capsaicinoid biosynthesis, such as acyltransferase 3 (AT3) and acyl-ACP thioesterase (FatA).	Capsaicin	248-257	glutamine synthetase	Capsicum annuum	70-90
32033346-7	2020	The expression and activities of glutamic acid synthetase (GOGAT) and glutamine synthetase (GS) that are involved in ammonium assimilation were affected by adjusting the ammonium-N proportion, and they were significantly positively correlated with capsaicin, dihydrocapsaicin contents, capsaicinoid synthetase (CS), as well as the relative expression levels of genes related to capsaicinoid biosynthesis, such as acyltransferase 3 (AT3) and acyl-ACP thioesterase (FatA).	Capsaicin	248-257	oleoyl-acyl carrier protein thioesterase, chloroplastic-like	Capsicum annuum	464-468
32033346-7	2020	The expression and activities of glutamic acid synthetase (GOGAT) and glutamine synthetase (GS) that are involved in ammonium assimilation were affected by adjusting the ammonium-N proportion, and they were significantly positively correlated with capsaicin, dihydrocapsaicin contents, capsaicinoid synthetase (CS), as well as the relative expression levels of genes related to capsaicinoid biosynthesis, such as acyltransferase 3 (AT3) and acyl-ACP thioesterase (FatA).	Capsaicin	286-298	glutamine synthetase	Capsicum annuum	70-90
32033346-7	2020	The expression and activities of glutamic acid synthetase (GOGAT) and glutamine synthetase (GS) that are involved in ammonium assimilation were affected by adjusting the ammonium-N proportion, and they were significantly positively correlated with capsaicin, dihydrocapsaicin contents, capsaicinoid synthetase (CS), as well as the relative expression levels of genes related to capsaicinoid biosynthesis, such as acyltransferase 3 (AT3) and acyl-ACP thioesterase (FatA).	Capsaicin	286-298	oleoyl-acyl carrier protein thioesterase, chloroplastic-like	Capsicum annuum	464-468
32033346-7	2020	The expression and activities of glutamic acid synthetase (GOGAT) and glutamine synthetase (GS) that are involved in ammonium assimilation were affected by adjusting the ammonium-N proportion, and they were significantly positively correlated with capsaicin, dihydrocapsaicin contents, capsaicinoid synthetase (CS), as well as the relative expression levels of genes related to capsaicinoid biosynthesis, such as acyltransferase 3 (AT3) and acyl-ACP thioesterase (FatA).	Capsaicin	378-390	glutamine synthetase	Capsicum annuum	70-90
32033346-7	2020	The expression and activities of glutamic acid synthetase (GOGAT) and glutamine synthetase (GS) that are involved in ammonium assimilation were affected by adjusting the ammonium-N proportion, and they were significantly positively correlated with capsaicin, dihydrocapsaicin contents, capsaicinoid synthetase (CS), as well as the relative expression levels of genes related to capsaicinoid biosynthesis, such as acyltransferase 3 (AT3) and acyl-ACP thioesterase (FatA).	Capsaicin	378-390	oleoyl-acyl carrier protein thioesterase, chloroplastic-like	Capsicum annuum	464-468
31577558-8	2020	Local injection of nerve growth factor (3 microg/50 microl) or the TRPV1 agonist capsaicin (1 mug/50 mul), but not neurotrophin-3 injection (1 microg/50 microl), resulted in long-lasting facial heat hyperalgesia, which was both significantly reduced by previous neurotrophin-3 local treatment.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-72
31577558-8	2020	Local injection of nerve growth factor (3 microg/50 microl) or the TRPV1 agonist capsaicin (1 mug/50 mul), but not neurotrophin-3 injection (1 microg/50 microl), resulted in long-lasting facial heat hyperalgesia, which was both significantly reduced by previous neurotrophin-3 local treatment.	Capsaicin	81-90	neurotrophin 3	Rattus norvegicus	262-276
31661581-6	2020	Phenylephrine at 30 mM caused calcium transients in cultured trigeminal ganglion neurons responding to the TRPV1 agonist capsaicin and in HEK293T cells expressing human TRPV1.	Capsaicin	121-130	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
31864799-3	2020	Among them, antagonist 36 exhibited potent and selective antagonism toward capsaicin for hTRPV1 and mTRPV1.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-95
31864799-3	2020	Among them, antagonist 36 exhibited potent and selective antagonism toward capsaicin for hTRPV1 and mTRPV1.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	100-106
31912230-1	2020	Sensory nerves sensitive to capsaicin are afferent nerve fibers which contain TRPV1 channels.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
31701438-0	2020	Capsaicin-Induced Impairment of Functional Network Dynamics in Mouse Hippocampus via a TrpV1 Receptor-Independent Pathway: Putative Involvement of Na+/K+-ATPase.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	87-92
31712319-3	2020	Capsaicin, a dietary factor activating TRPV1, can inhibit obesity induced by high-fat diet (HFD), but whether capsaicin inhibits BAT loss and the underlying mechanism remain unclear.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	39-44
31712319-4	2020	In this study, we determined that the inhibitory effects of capsaicin on HFD-induced obesity and BAT whitening were dependent on the participation of SIRT3, a critical mitochondrial deacetylase.	Capsaicin	60-69	sirtuin 3	Homo sapiens	150-155
31712319-5	2020	SIRT3 also mediated all of the beneficial effects of capsaicin on alleviating reactive oxygen species generation, elevating mitochondrial activity, and restricting mitochondrial calcium overload induced by HFD.	Capsaicin	53-62	sirtuin 3	Homo sapiens	0-5
31712319-7	2020	In addition, HFD also inhibits AMPK activity to reduce SIRT3 expression, which could be reversed by capsaicin.	Capsaicin	100-109	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	31-35
31712319-7	2020	In addition, HFD also inhibits AMPK activity to reduce SIRT3 expression, which could be reversed by capsaicin.	Capsaicin	100-109	sirtuin 3	Homo sapiens	55-60
31701438-1	2020	The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1).	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	80-129
31701438-1	2020	The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1).	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	131-136
31701438-1	2020	The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1).	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	80-129
31701438-1	2020	The vanilloid compound capsaicin (Cp) is best known to bind to and activate the transient receptor potential vanilloid receptor-1 (TrpV1).	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	131-136
31701438-2	2020	A growing number of studies use capsaicin as a tool to study the role of TrpV1 in the central nervous system (CNS).	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
31701438-3	2020	Although most of capsaicin"s CNS effects have been reported to be mediated by TrpV1 activation, evidence exists that capsaicin can also trigger functional changes in hippocampal activity independently of TrpV1.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
31701438-4	2020	Recently, we have reported that capsaicin induces impairment in hippocampal gamma oscillations via a TrpV1-independent pathway.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	101-106
31701438-10	2020	In conclusion, our study shows that capsaicin in a TrpV1-independent manner and possibly involving Na+/K+-ATPase activity can impair cognition-relevant functional network dynamics such as gamma oscillations and provides important data regarding the use of capsaicin as a tool to study TrpV1 function in the CNS.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	51-56
31701438-10	2020	In conclusion, our study shows that capsaicin in a TrpV1-independent manner and possibly involving Na+/K+-ATPase activity can impair cognition-relevant functional network dynamics such as gamma oscillations and provides important data regarding the use of capsaicin as a tool to study TrpV1 function in the CNS.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	285-290
31814000-1	2020	The transient receptor potential vanilloid 1 (TRPV1) protein is a pain receptor that elicits a hot sensation when an organism eats the capsaicin of red chili peppers.	Capsaicin	135-144	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
31392556-11	2020	Renal infusion of capsaicin increased c-Fos expression in the paraventricular nucleus (PVN) of hypothalamus.	Capsaicin	18-27	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	38-43
31992767-7	2020	In neurons from Jedi-1 knockout (KO) mice, there was an increase in the fraction of capsaicin-sensitive cells relative to wild type (WT) controls.	Capsaicin	84-93	platelet endothelial aggregation receptor 1	Mus musculus	16-22
31952468-7	2020	In DRG neurons and TRPV1-expressing HEK cells, heat sensitivity was restricted to capsaicin sensitive cells.	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-24
32378567-4	2020	We observed that lateral mobility of TRPV1 increased after treatment of cells with capsaicin or naloxone (a nonselective opioid receptor antagonist) but not with DAMGO (a mu-opioid receptor agonist).	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
32741949-0	2020	Protective Effect of Antioxidative Liposomes Co-encapsulating Astaxanthin and Capsaicin on CCl4-Induced Liver Injury.	Capsaicin	78-87	C-C motif chemokine ligand 4	Rattus norvegicus	91-95
31998070-1	2019	The tetrameric capsaicin receptor transient receptor potential vanilloid 1 (TRPV1) in mammals has evolved the capability to integrate pain signal arising from harmful temperature and chemical irritants.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
31998070-4	2019	By introducing capsaicin-insensitive S512F mutant subunits into the TRPV1 channel, we found that binding of the first ligand results in low but clear channel activation.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
31998070-6	2019	The non-vanilloid agonist 2-aminoethoxydiphenyl borate (2-APB) differs from that of capsaicin in the TRPV1 channel opening mechanism activating all S512F-mutated TRPV1 channels.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	101-106
31998070-6	2019	The non-vanilloid agonist 2-aminoethoxydiphenyl borate (2-APB) differs from that of capsaicin in the TRPV1 channel opening mechanism activating all S512F-mutated TRPV1 channels.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	162-167
31998070-7	2019	Two or more wild-type TRPV1 subunits are also required for full anandamide-induced channel activation, a cannabinoid that shares overlapping binding-pocket to capsaicin.	Capsaicin	159-168	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
31617735-1	2020	Liquiritin apioside (LA), a main flavonoid component of licorice, reportedly suppresses cough responses to inhalation of aerosolized capsaicin (CAP, a stimulant to TRPV1) in conscious guinea pigs via acting on peripheral nerves.	Capsaicin	133-142	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	164-169
31617735-1	2020	Liquiritin apioside (LA), a main flavonoid component of licorice, reportedly suppresses cough responses to inhalation of aerosolized capsaicin (CAP, a stimulant to TRPV1) in conscious guinea pigs via acting on peripheral nerves.	Capsaicin	144-147	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	164-169
31617735-9	2020	Owing that TRPV1 receptors of laryngeal C-fibers are responsible for the CAP-triggered apneas, LA impact on the activity of laryngeal C-neurons retrogradely traced by DiI was subsequently studied using a patch-clamp approach.	Capsaicin	73-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	11-16
32378567-3	2020	Here we investigated the effect of the prototypical TRPV1 agonist capsaicin and selected opioid ligands on TRPV1 movement in the plasma membrane and intracellular calcium levels in HEK293 cells expressing TRPV1 tagged with cyan fluorescent protein (CFP).	Capsaicin	66-75	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
32378567-3	2020	Here we investigated the effect of the prototypical TRPV1 agonist capsaicin and selected opioid ligands on TRPV1 movement in the plasma membrane and intracellular calcium levels in HEK293 cells expressing TRPV1 tagged with cyan fluorescent protein (CFP).	Capsaicin	66-75	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
32378567-6	2020	The increased TRPV1 movement and calcium influx induced by capsaicin and naloxone were blocked by the TRPV1 antagonist capsazepine.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
32378567-6	2020	The increased TRPV1 movement and calcium influx induced by capsaicin and naloxone were blocked by the TRPV1 antagonist capsazepine.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
31724206-0	2020	alpha-Glucosidase, alpha-amylase, and tyrosinase inhibitory potential of capsaicin and dihydrocapsaicin.	Capsaicin	73-82	tyrosinase	Homo sapiens	38-48
31697943-3	2020	Cell bodies for the vagal afferent fibers are located within the nodose ganglion (NG) and the majority of vagal afferent axons are unmyelinated C fibers that are sensitive to capsaicin through activation of transient receptor potential vanilloid-1 (TRPV1) channels.	Capsaicin	175-184	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	207-247
31697943-3	2020	Cell bodies for the vagal afferent fibers are located within the nodose ganglion (NG) and the majority of vagal afferent axons are unmyelinated C fibers that are sensitive to capsaicin through activation of transient receptor potential vanilloid-1 (TRPV1) channels.	Capsaicin	175-184	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	249-254
31721716-4	2020	The low (1mg/kg) or high (100mg/kg) dose of capsaicin was injected subcutaneously before I/R to activate or desensitize TRPV1, respectively.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
31724206-3	2020	This study aims to investigate the antidiabetic properties and anti-melanin synthesis of capsaicinoids by studying the inhibitory activity of capsaicin and dihydrocapsaicin with alpha-glucosidase, alpha-amylase, and tyrosinase.	Capsaicin	89-102	tyrosinase	Homo sapiens	216-226
31724206-3	2020	This study aims to investigate the antidiabetic properties and anti-melanin synthesis of capsaicinoids by studying the inhibitory activity of capsaicin and dihydrocapsaicin with alpha-glucosidase, alpha-amylase, and tyrosinase.	Capsaicin	89-98	tyrosinase	Homo sapiens	216-226
31724206-4	2020	The results revealed that dihydrocapsaicin with IC50 had 4.13-fold and 3.00-fold for alpha-glucosidase and alpha-amylase, respectively, which are lower than capsaicin.	Capsaicin	33-42	sucrase-isomaltase	Homo sapiens	85-102
31724206-5	2020	Moreover, the IC50 of capsaicin with tyrosinase had 1.73 times less than dihydrocapsaicin.	Capsaicin	22-31	tyrosinase	Homo sapiens	37-47
31724206-6	2020	The inhibition constant (Ki ) also supported that the dihydrocapsaicin had higher inhibitory activity than capsaicin against alpha-glucosidase and alpha-amylase, but lower inhibitory activity than capsaicin on tyrosinase.	Capsaicin	61-70	sucrase-isomaltase	Homo sapiens	125-142
31724206-6	2020	The inhibition constant (Ki ) also supported that the dihydrocapsaicin had higher inhibitory activity than capsaicin against alpha-glucosidase and alpha-amylase, but lower inhibitory activity than capsaicin on tyrosinase.	Capsaicin	61-70	tyrosinase	Homo sapiens	210-220
31724206-6	2020	The inhibition constant (Ki ) also supported that the dihydrocapsaicin had higher inhibitory activity than capsaicin against alpha-glucosidase and alpha-amylase, but lower inhibitory activity than capsaicin on tyrosinase.	Capsaicin	107-116	sucrase-isomaltase	Homo sapiens	125-142
31724206-9	2020	PRACTICAL APPLICATIONS: This study presents the inhibition potential of capsaicin and dihydrocapsaicin on antidiabetes and anti-melanin properties by standard methods for inhibitory activity against alpha-glucosidase, alpha-amylase, and tyrosinase.	Capsaicin	72-81	sucrase-isomaltase	Homo sapiens	199-216
31724206-9	2020	PRACTICAL APPLICATIONS: This study presents the inhibition potential of capsaicin and dihydrocapsaicin on antidiabetes and anti-melanin properties by standard methods for inhibitory activity against alpha-glucosidase, alpha-amylase, and tyrosinase.	Capsaicin	72-81	tyrosinase	Homo sapiens	237-247
31576531-3	2020	We expressed the transient receptor potential vanilloid 1 (TRPV1) channel from rat (r) in worms" ASH neurons and determined its sensitivity to the tarantula double-knot toxin (DkTx) and the active component of chili peppers (capsaicin).	Capsaicin	225-234	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	17-57
31241438-3	2020	Another heteroaryl urea derivative, A-425619 1, has been reported to be a potent and selective TRPV1 antagonist of capsaicin-evoked receptor activation with an IC50 value of 4 nM in hTRPV1.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	95-100
31241438-3	2020	Another heteroaryl urea derivative, A-425619 1, has been reported to be a potent and selective TRPV1 antagonist of capsaicin-evoked receptor activation with an IC50 value of 4 nM in hTRPV1.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	182-188
31633584-8	2020	In EC-PVAT- depleted of CGRP via capsaicin, nicotine- and TNS-induced vasorelaxation was almost absent.	Capsaicin	33-42	calcitonin-related polypeptide alpha	Rattus norvegicus	24-28
32581185-4	2020	Further, there are several reports showing that capsaicin, a specific agonist of TRPV1, can improve OD.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
31576531-3	2020	We expressed the transient receptor potential vanilloid 1 (TRPV1) channel from rat (r) in worms" ASH neurons and determined its sensitivity to the tarantula double-knot toxin (DkTx) and the active component of chili peppers (capsaicin).	Capsaicin	225-234	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
32985330-1	2020	Capsaicin is an agonist of transient receptor potential cation channel subfamily V member 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-91
32985330-1	2020	Capsaicin is an agonist of transient receptor potential cation channel subfamily V member 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	93-98
33307981-3	2020	Here we show that by augmenting forskolin (FSK) and growth factor supplementation with NGF or GDNF, 50B11 cultures can be driven to acquire differential functional responses to common nociceptive agonists capsaicin and ATP respectively.	Capsaicin	205-214	nerve growth factor	Rattus norvegicus	87-90
32985330-2	2020	Strong TRPV1 stimulation with capsaicin causes mitochondrial damage in primary sensory neurons.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	7-12
33307981-3	2020	Here we show that by augmenting forskolin (FSK) and growth factor supplementation with NGF or GDNF, 50B11 cultures can be driven to acquire differential functional responses to common nociceptive agonists capsaicin and ATP respectively.	Capsaicin	205-214	glial cell derived neurotrophic factor	Rattus norvegicus	94-98
32985330-5	2020	Further, capsaicin-treated mice exhibited decreased sensitivity to noxious heat stimulation, indicating TRPV1 dysfunction, in parallel with the mitochondrial damage in the trigeminal ganglion neurons.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	104-109
32985330-6	2020	To analyze the capsaicin-induced mitochondrial damage and its relevant cellular events in detail, we performed cell-based assays using TRPV1-expressing PC12 cells.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	135-140
32985330-11	2020	Collectively, although trigeminal ganglion neurons transiently exhibit mitochondrial damage and TRPV1 dysfunction following moderate capsaicin exposure, they appear to be resilient to such a challenge.	Capsaicin	133-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
31647972-6	2020	In whole-cell patch-clamp experiments on HEK293 cells transfected with TRPV1, capsaicin (10 muM) generated inward currents that were blocked by SB-366791 and by both native and recombinant PnTx3-5 by 47 +- 1.4 %; 54 +- 7.8 % and 56 +- 9.0 %, respectively.	Capsaicin	78-87	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
31647972-1	2020	Capsaicin, an agonist of TRPV1, evokes intracellular [Ca2+] transients and glutamate release from perfused trigeminal ganglion.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-30
31230211-1	2020	Topical irritants such as capsaicin (CAP), peppermint oil (PO), and mustard oil (MO) are effective in relieving inflammatory muscle pain.	Capsaicin	26-35	sorbin and SH3 domain containing 1	Rattus norvegicus	37-40
31647972-6	2020	In whole-cell patch-clamp experiments on HEK293 cells transfected with TRPV1, capsaicin (10 muM) generated inward currents that were blocked by SB-366791 and by both native and recombinant PnTx3-5 by 47 +- 1.4 %; 54 +- 7.8 % and 56 +- 9.0 %, respectively.	Capsaicin	78-87	latexin	Homo sapiens	92-95
31647972-4	2020	PnTx3-5 (40 nM) and SB-366791 (3 muM) also inhibited the capsaicin-induced increase in intracellular Ca2+ in HEK293 cells transfected with TRPV1 by 75 +- 16 % and 84 +- 3.2 %, respectively.	Capsaicin	57-66	latexin	Homo sapiens	33-36
31647972-4	2020	PnTx3-5 (40 nM) and SB-366791 (3 muM) also inhibited the capsaicin-induced increase in intracellular Ca2+ in HEK293 cells transfected with TRPV1 by 75 +- 16 % and 84 +- 3.2 %, respectively.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	139-144
31493465-7	2019	Here, we studied whether or not chronic pain could alter the response of TRPV1 channels to exogenous, capsaicin through study of synaptic transmission and neural activity in rat SG neurons.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	73-78
31676602-1	2019	Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory neurons of the pain pathway.	Capsaicin	129-138	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-48
31676602-1	2019	Transient receptor potential vanilloid subtype 1 (TRPV1) is a nonselective cationic channel activated by painful stimuli such as capsaicin and noxious heat, and enriched in sensory neurons of the pain pathway.	Capsaicin	129-138	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	50-55
31022566-11	2019	Capsaicin, 6-gingerol and 6-shogaol had good broad antibacterial activity with MIC values ranging from 8 to 256 mg/L against effluxing MRSA strains SA1199B (NorA), XU212 (TetK) and RN4220 (MsrA).	Capsaicin	0-9	methionine sulfoxide reductase A	Homo sapiens	189-193
31589869-10	2019	Capsaicin is used as a pharmacological tool to induce secretion of endogenous perivascular CGRP and our studies confirm that the antibody reach the perivascular sensory synaptic cleft and blocks the vasodilatory response of released CGRP in the present in vitro model.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	91-95
31589869-10	2019	Capsaicin is used as a pharmacological tool to induce secretion of endogenous perivascular CGRP and our studies confirm that the antibody reach the perivascular sensory synaptic cleft and blocks the vasodilatory response of released CGRP in the present in vitro model.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	233-237
31835716-1	2019	Somatostatin released from the capsaicin-sensitive sensory nerves mediates analgesic and anti-inflammatory effects via the somatostatin sst4 receptor without endocrine actions.	Capsaicin	31-40	somatostatin receptor 4	Mus musculus	136-140
31822735-4	2019	Fluorescence binding and isothermal titration calorimetric measurements suggested that quercetin and capsaicin bind to SphK1 with an excellent affinity, and significantly inhibits its activity with an admirable IC50 values.	Capsaicin	101-110	sphingosine kinase 1	Homo sapiens	119-124
31822735-8	2019	In conclusion, we infer that quercetin and capsaicin provide a chemical scaffold to develop potent and selective inhibitors of SphK1 after required modifications for the clinical management of cancer.	Capsaicin	43-52	sphingosine kinase 1	Homo sapiens	127-132
31262222-0	2019	pHluorin-tagged TRPV1 shines light on capsaicin tachyphylaxis.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-21
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Capsaicin	22-31	tumor necrosis factor	Homo sapiens	88-97
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Capsaicin	22-31	interleukin 6	Homo sapiens	99-103
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Capsaicin	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	109-114
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Capsaicin	22-31	C-X-C motif chemokine ligand 8	Homo sapiens	115-119
31751886-10	2019	Besides, Curcumin and Capsaicin down-regulated expression of pro-inflammatory cytokines TNF-alpha, IL-6, and CXCL8/IL-8 and up regulated the expression of IL-10, a sign of lowered M1/M2 ratio relating to abrogation of inflammation.	Capsaicin	22-31	interleukin 10	Homo sapiens	155-160
31539192-0	2019	Capsaicin Improves Glucose Tolerance and Insulin Sensitivity Through Modulation of the Gut Microbiota-Bile Acid-FXR Axis in Type 2 Diabetic db/db Mice.	Capsaicin	0-9	nuclear receptor subfamily 1, group H, member 4	Mus musculus	112-115
31539192-5	2019	Furthermore, CAP inhibited the increase in abundance of the genus Lactobacillus and its bile salt hydrolase (BSH) activity compared with levels in chow-fed mice, thereby leading to the accumulation of tauro-beta-muricholic acid (TbetaMCA), a natural antagonist of the farnesoid X receptor (FXR) that is involved in the regulation of BA and glucose metabolism.	Capsaicin	13-16	nuclear receptor subfamily 1, group H, member 4	Mus musculus	290-293
31539192-6	2019	CAP-induced suppression of enterohepatic FXR-fibroblast growth factor 15 (FGF15) signaling contributed to the increased BA pool size, followed by increases in the expression of cholesterol 7alpha-hydroxylase (CYP7A1) and hepatic BA synthesis.	Capsaicin	0-3	fibroblast growth factor 15	Mus musculus	41-72
31539192-6	2019	CAP-induced suppression of enterohepatic FXR-fibroblast growth factor 15 (FGF15) signaling contributed to the increased BA pool size, followed by increases in the expression of cholesterol 7alpha-hydroxylase (CYP7A1) and hepatic BA synthesis.	Capsaicin	0-3	fibroblast growth factor 15	Mus musculus	74-79
31539192-6	2019	CAP-induced suppression of enterohepatic FXR-fibroblast growth factor 15 (FGF15) signaling contributed to the increased BA pool size, followed by increases in the expression of cholesterol 7alpha-hydroxylase (CYP7A1) and hepatic BA synthesis.	Capsaicin	0-3	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	177-207
31539192-6	2019	CAP-induced suppression of enterohepatic FXR-fibroblast growth factor 15 (FGF15) signaling contributed to the increased BA pool size, followed by increases in the expression of cholesterol 7alpha-hydroxylase (CYP7A1) and hepatic BA synthesis.	Capsaicin	0-3	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	209-215
31539192-8	2019	CONCLUSIONS: CAP-induced improvements in BA and glucose metabolism are partially mediated by the gut microbiota-BA-enterohepatic FXR axis in db/db mice.	Capsaicin	13-16	nuclear receptor subfamily 1, group H, member 4	Mus musculus	129-132
31493465-11	2019	Importantly, the capsaicin-induced inward currents were conducted by TRPV1 and required calcium influx that was independent of voltage-gated calcium channels.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-74
31493465-12	2019	Our study provides fundamental evidence that chronic inflammation and neuropathic pain models amplify the release of glutamate through the activation of TRPV1 in central axon terminals, and that facilitation of TRPV1 function in rat spinal SG neurons may contribute to enhanced capsaicin-induced inward currents.	Capsaicin	278-287	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	211-216
31701920-14	2019	Capsaicin was utilized in SIRT6-overexpressed cells.	Capsaicin	0-9	sirtuin 6	Homo sapiens	26-31
31795171-13	2019	Pharmacologic studies, involving 2516 patients revealed efficacy for capsaicin 8% over placebo (mean difference -8.04 [95% CI: -14.92 -1.15], smoked cannabis (where pooling data for meta-analysis was not possible) and recombinant Nerve Growth Factor.	Capsaicin	69-78	nerve growth factor	Homo sapiens	230-249
31701920-15	2019	Capsaicin therapy counteracted the effect of SIRT6 overexpression on OD, and markedly decreased OD.	Capsaicin	0-9	sirtuin 6	Homo sapiens	45-50
31377198-4	2019	Depolarization with KCl, capsaicin, or the protein kinase A activator 6-benzoyl-cAMP also induced Y1 receptor internalization, presumably by releasing NPY.	Capsaicin	25-34	neuropeptide Y	Rattus norvegicus	151-154
31314954-10	2019	This study also proved that TRPV1 antagonists can inhibit a more complex, non-capsaicin dependent thermally induced pain signal.	Capsaicin	78-87	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
31377198-7	2019	Dorsal root immersion in capsaicin, but not its electrical stimulation, also induced NPY release.	Capsaicin	25-34	neuropeptide Y	Rattus norvegicus	85-88
31296147-2	2019	Transient receptor potential vanilloid subfamily member 1 (TRPV1), a new target of the analgesics, activated by heat, protons and capsaicin and the hot component of pepper.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
31377198-8	2019	This was blocked by CNQX, suggesting that part of the NPY released by capsaicin was from dorsal horn neurons receiving synapses from primary afferents and not from the afferent themselves.	Capsaicin	70-79	neuropeptide Y	Rattus norvegicus	54-57
31383364-12	2019	NGF increased capsaicin current amplitude from 144 (42) to 840 (132) pA (P&lt;0.05), which was blocked by the TRPV1 antagonist 5"-iodoresiniferatoxin.	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	110-115
31676846-4	2019	By contrast, capsaicin, which evokes a mix of itch and pain sensations, enhances both excitatory and inhibitory spontaneous synaptic transmission onto GRPR neurons.	Capsaicin	13-22	gastrin releasing peptide receptor	Homo sapiens	151-155
31632242-12	2019	Mitigation of NIHL could be achieved by using capsaicin (TRPV1 agonist that rapidly desensitizes TRPV1.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
31632242-12	2019	Mitigation of NIHL could be achieved by using capsaicin (TRPV1 agonist that rapidly desensitizes TRPV1.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-102
31401394-6	2019	Treatment with TRPV1 agonist Capsaicin inhibits the growth of HCC cells in xenograft models.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
31231923-1	2019	INTRODUCTION: Topical capsaicin is commonly employed to experimentally induce central sensitization (CS) in humans.	Capsaicin	22-31	citrate synthase	Homo sapiens	101-103
31231923-11	2019	The heat-capsaicin technique may be employed to assess differing magnitudes of CS induction and enables future studies investigating the development and progression of CS in humans.	Capsaicin	9-18	citrate synthase	Homo sapiens	79-81
31231923-11	2019	The heat-capsaicin technique may be employed to assess differing magnitudes of CS induction and enables future studies investigating the development and progression of CS in humans.	Capsaicin	9-18	citrate synthase	Homo sapiens	168-170
31683728-6	2019	Screening experiment using fractional factorial designs indicated that the amount of sample loading, pH, and concentration of [Emim] [OAc] and PEG 6000 significantly affect the yield of capsaicin.	Capsaicin	186-195	progestagen associated endometrial protein	Homo sapiens	143-146
31671779-0	2019	The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.	Capsaicin	42-51	lysine acetyltransferase 5	Homo sapiens	84-89
31671779-0	2019	The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor.	Capsaicin	42-51	androgen receptor	Homo sapiens	104-121
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	Capsaicin	17-26	androgen receptor	Homo sapiens	45-47
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	Capsaicin	17-26	kallikrein related peptidase 3	Homo sapiens	49-74
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	Capsaicin	17-26	BCL2 like 1	Homo sapiens	79-85
31671779-5	2019	Sulforaphane and capsaicin decreased nuclear AR, prostate specific antigen and Bcl-XL levels, and cell proliferation induced by androgen and Tip60 in LNCaP cells.	Capsaicin	17-26	lysine acetyltransferase 5	Homo sapiens	141-146
31671779-7	2019	The protective role of sulforaphane and capsaicin on prostate cancer may rely on mechanisms involving the inhibition of Tip60, AR and HIF-1alpha effects.	Capsaicin	40-49	lysine acetyltransferase 5	Homo sapiens	120-125
31671779-7	2019	The protective role of sulforaphane and capsaicin on prostate cancer may rely on mechanisms involving the inhibition of Tip60, AR and HIF-1alpha effects.	Capsaicin	40-49	androgen receptor	Homo sapiens	127-129
31671779-7	2019	The protective role of sulforaphane and capsaicin on prostate cancer may rely on mechanisms involving the inhibition of Tip60, AR and HIF-1alpha effects.	Capsaicin	40-49	hypoxia inducible factor 1 subunit alpha	Homo sapiens	134-144
31681615-4	2019	TRPV1 channel, known as a capsaicin receptor, was recently documented to be expressed on the cells of the immune system but also aberrantly expressed in the several tumor types.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
31681615-7	2019	Furthermore, in several studies, activation of TRPV1 by capsaicin was associated with anti-cancer effects.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
31325598-1	2019	BACKGROUND: The transient receptor potential vanilloid subtype-1 (TRPV1) channel is a calcium selective ion channel that responds to various stimuli such as heat, low pH, and capsaicin.	Capsaicin	175-184	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-64
31383364-13	2019	Exogenous NGF enhanced capsaicin-induced Akt/ERK and TRPV1 activation in PC12 neuroendocrine tumour cells in culture.	Capsaicin	23-32	AKT serine/threonine kinase 1	Rattus norvegicus	41-44
31325598-1	2019	BACKGROUND: The transient receptor potential vanilloid subtype-1 (TRPV1) channel is a calcium selective ion channel that responds to various stimuli such as heat, low pH, and capsaicin.	Capsaicin	175-184	transient receptor potential cation channel subfamily V member 1	Homo sapiens	66-71
31383364-13	2019	Exogenous NGF enhanced capsaicin-induced Akt/ERK and TRPV1 activation in PC12 neuroendocrine tumour cells in culture.	Capsaicin	23-32	Eph receptor B1	Rattus norvegicus	45-48
31383364-13	2019	Exogenous NGF enhanced capsaicin-induced Akt/ERK and TRPV1 activation in PC12 neuroendocrine tumour cells in culture.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	53-58
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	228-237	interleukin 6	Homo sapiens	79-83
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	228-237	transforming growth factor beta 1	Homo sapiens	88-96
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Capsaicin	13-22	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	59-64
30607863-10	2019	Following damage of the nasal sensory nerves by capsaicin, the protein and mRNA levels of SP, VIP, and NGF were reduced.	Capsaicin	48-57	vasoactive intestinal peptide	Rattus norvegicus	94-97
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Capsaicin	13-22	interleukin 6	Homo sapiens	66-70
31486959-0	2019	Curcumin and capsaicin modulates LPS induced expression of COX-2, IL-6 and TGF-beta in human peripheral blood mononuclear cells.	Capsaicin	13-22	transforming growth factor beta 1	Homo sapiens	75-83
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Capsaicin	48-57	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	111-116
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Capsaicin	48-57	interleukin 6	Homo sapiens	118-122
31486959-2	2019	RT-PCR analysis has shown that the curcumin and capsaicin significantly reduced LPS induced over expression of COX-2, IL-6 and TGF-beta in PBMCs.	Capsaicin	48-57	transforming growth factor beta 1	Homo sapiens	127-135
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	37-46	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	37-46	interleukin 6	Homo sapiens	79-83
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	37-46	transforming growth factor beta 1	Homo sapiens	88-96
31486959-4	2019	Further, The docking of curcumin and capsaicin at the active pockets of COX-2, IL-6 and TGF-beta has shown - 3.90, - 4.49 and - 5.61 kcal/mol binding energy for curcumin and - 3.80, - 4.78 and - 5.76 kcal/mol binding energy for capsaicin, while multiple ligand simultaneous docking (MLSD) of both molecules has shown higher binding energy of - 4.24, - 5.35 and - 5.83 kcal/mol respectively.	Capsaicin	228-237	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	72-77
31190106-8	2019	However, TRPV-1 agonists capsaicin significantly abrogated the neuroprotective effects of EA pretreatment in MCAO rats accompanying enhancement of TRPV-1 expression.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-15
31190106-8	2019	However, TRPV-1 agonists capsaicin significantly abrogated the neuroprotective effects of EA pretreatment in MCAO rats accompanying enhancement of TRPV-1 expression.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	147-153
30607863-10	2019	Following damage of the nasal sensory nerves by capsaicin, the protein and mRNA levels of SP, VIP, and NGF were reduced.	Capsaicin	48-57	nerve growth factor	Rattus norvegicus	103-106
31566018-3	2022	The effect of capsaicin through sensory neurons via TRPV1 activation has been well studied, but its non-neuronal effects are still not extensively explored.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
31527261-9	2019	Last, IR76b"s response-lowering ability has specificity: IR76b mutants and WT showed comparable responses to capsaicin when the mammalian capsaicin receptor VR1 was ectopically expressed in their sweet neurons.	Capsaicin	109-118	Ionotropic receptor 76b	Drosophila melanogaster	6-11
31527261-9	2019	Last, IR76b"s response-lowering ability has specificity: IR76b mutants and WT showed comparable responses to capsaicin when the mammalian capsaicin receptor VR1 was ectopically expressed in their sweet neurons.	Capsaicin	109-118	Ionotropic receptor 76b	Drosophila melanogaster	57-62
31219220-6	2019	When DRG neurons were firstly illuminated by the different laser protocols and then stimulated with the natural transient receptor potential cation channel subfamily V member 1 (TRPV1) ligand capsaicin, only the 970 nm wavelength reduced the calcium response, in both amplitude and frequency.	Capsaicin	192-201	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	112-176
31219220-6	2019	When DRG neurons were firstly illuminated by the different laser protocols and then stimulated with the natural transient receptor potential cation channel subfamily V member 1 (TRPV1) ligand capsaicin, only the 970 nm wavelength reduced the calcium response, in both amplitude and frequency.	Capsaicin	192-201	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	178-183
30989631-4	2019	We identify a bidirectional, dose-related impact of capsaicin, a TRPV1 agonist, on sensory neurons and their axons with rises in their outgrowth plasticity at low doses and toxic neurodegeneration at high doses.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
31566018-6	2022	Results of this study suggest a significant protective effect of capsaicin against oxidative stress by enhancing FRAP, GSH level, PMRS activity and ameliorating ROS, MDA, PCO and AOPP.	Capsaicin	65-74	mechanistic target of rapamycin kinase	Homo sapiens	113-117
31202991-2	2019	The SAR analysis indicated that 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole analogues displayed excellent antagonism of hTRPV1 activation by capsaicin and showed better potency compared to the corresponding dihydroindole analogues.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-124
31561455-4	2019	Capsaicin-induced IL-1beta, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-alpha upregulation was observed on day 7.	Capsaicin	0-9	interleukin 1 beta	Rattus norvegicus	18-26
31561455-4	2019	Capsaicin-induced IL-1beta, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-alpha upregulation was observed on day 7.	Capsaicin	0-9	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	28-33
31561455-4	2019	Capsaicin-induced IL-1beta, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-alpha upregulation was observed on day 7.	Capsaicin	0-9	interleukin 6	Rattus norvegicus	35-39
31557799-5	2019	In hypertensive rats capsaicin increased the levels of NO, BH4, cGMP, and TAC, and reduced PDE-3 and MDA.	Capsaicin	21-30	phosphodiesterase 4D, cAMP-specific-like 1	Rattus norvegicus	91-96
31561455-4	2019	Capsaicin-induced IL-1beta, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-alpha upregulation was observed on day 7.	Capsaicin	0-9	caspase 1	Rattus norvegicus	41-50
31561455-4	2019	Capsaicin-induced IL-1beta, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-alpha upregulation was observed on day 7.	Capsaicin	0-9	NLR family, pyrin domain containing 1A	Rattus norvegicus	95-100
31561455-4	2019	Capsaicin-induced IL-1beta, COX-2, IL-6, caspase-1, and NGF upregulation on day 3 and 7, while NALP1 and TNF-alpha upregulation was observed on day 7.	Capsaicin	0-9	tumor necrosis factor	Rattus norvegicus	105-114
31557799-1	2019	The purpose of the present study was to analyze the actions of transient receptor potential vanilloid type 1 (TRPV1) agonist capsaicin (CS) and of its antagonist capsazepine (CZ), on cardiac function as well as endothelial biomarkers and some parameters related with nitric oxide (NO) release in L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats.	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	63-108
31557799-1	2019	The purpose of the present study was to analyze the actions of transient receptor potential vanilloid type 1 (TRPV1) agonist capsaicin (CS) and of its antagonist capsazepine (CZ), on cardiac function as well as endothelial biomarkers and some parameters related with nitric oxide (NO) release in L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats.	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	110-115
31557799-1	2019	The purpose of the present study was to analyze the actions of transient receptor potential vanilloid type 1 (TRPV1) agonist capsaicin (CS) and of its antagonist capsazepine (CZ), on cardiac function as well as endothelial biomarkers and some parameters related with nitric oxide (NO) release in L-NG-nitroarginine methyl ester (L-NAME)-induced hypertensive rats.	Capsaicin	136-138	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	110-115
31202991-4	2019	In vitro, using cells expressing recombinant human TRPV1 channels, 6g displayed potent antagonism activated by capsaicin (IC50 = 0.075 muM) and only partially blocked acid activation of TRPV1.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
31134453-8	2019	Upregulation of Fatty acid synthase (Fasn) and Adipose triglyceride lipase (Atgl/Pnpla2) by obestatin were reversed by both capsaicin and genistein.	Capsaicin	124-133	fatty acid synthase	Mus musculus	16-35
31423784-0	2019	Capsaicin Ameliorates the Redox Imbalance and Glucose Metabolism Disorder in an Insulin-Resistance Model via Circadian Clock-Related Mechanisms.	Capsaicin	0-9	insulin	Homo sapiens	80-87
31423784-3	2019	Capsaicin has been demonstrated with many beneficial effects including anti-obesity and anti-insulin resistance activities, yet whether the rhythmic expression of circadian clock genes are involved in the regulation of redox imbalance and glucose metabolism disorder by capsaicin remains unclear.	Capsaicin	0-9	insulin	Homo sapiens	93-100
31551772-2	2019	The transient receptor potential V1 ion channel (TRPV1) is a peripheral pain generator activated and sensitized by heat, capsaicin, and a variety of endogenous ligands.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-54
31551772-8	2019	Primary sensory neuron cultures also were treated with the latex extract or vehicle for 15 min followed by stimulation with the TRPV1 agonist capsaicin.	Capsaicin	142-151	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	128-133
31551772-10	2019	In sensory neurons, latex extract significantly reduced capsaicin-evoked CGRP release.	Capsaicin	56-65	calcitonin-related polypeptide alpha	Rattus norvegicus	73-77
31551772-11	2019	Blocking TRPV1, but not opioid receptors, attenuated the onset of analgesia and capsaicin-induced CGRP release.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-14
31551772-11	2019	Blocking TRPV1, but not opioid receptors, attenuated the onset of analgesia and capsaicin-induced CGRP release.	Capsaicin	80-89	calcitonin-related polypeptide alpha	Rattus norvegicus	98-102
31404587-6	2019	Diabetic animals pre-treated with Protein Kinase C (PKC)-alpha and -beta inhibitor (GO6976) or PKC-beta inhibitor (LY333531) significantly increased capsaicin-induced nociception in the TMJ higher protein levels of Na+/K+-ATPase pump in the trigeminal ganglia.	Capsaicin	149-158	protein kinase C, alpha	Rattus norvegicus	34-72
31404587-6	2019	Diabetic animals pre-treated with Protein Kinase C (PKC)-alpha and -beta inhibitor (GO6976) or PKC-beta inhibitor (LY333531) significantly increased capsaicin-induced nociception in the TMJ higher protein levels of Na+/K+-ATPase pump in the trigeminal ganglia.	Capsaicin	149-158	protein kinase C, alpha	Rattus norvegicus	95-103
31306713-11	2019	Capsaicin remarkably enhanced the reepithelialization of ulcer tissues and showed strong anti-inflammatory effect by reducing the expressions of THF-alpha and IL-6.	Capsaicin	0-9	interleukin 6	Homo sapiens	159-163
31487785-2	2019	Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown.	Capsaicin	192-201	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-80
31487785-2	2019	Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown.	Capsaicin	192-201	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
31487785-2	2019	Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown.	Capsaicin	192-201	kininogen 1	Homo sapiens	322-324
31487785-2	2019	Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown.	Capsaicin	203-206	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-80
31487785-2	2019	Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown.	Capsaicin	203-206	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
31487785-2	2019	Kv7 channels interact functionally with transient receptor potential vanilloid 1 (TRPV1) channels activated by endogenous and/or exogenous pain-inducing substances, such as bradykinin (BK) or capsaicin (CAP), respectively; however, whether Kv7 channels of specific molecular composition provide a dominant contribution in BK- or CAP-evoked responses is yet unknown.	Capsaicin	203-206	kininogen 1	Homo sapiens	322-324
31134453-8	2019	Upregulation of Fatty acid synthase (Fasn) and Adipose triglyceride lipase (Atgl/Pnpla2) by obestatin were reversed by both capsaicin and genistein.	Capsaicin	124-133	fatty acid synthase	Mus musculus	37-41
31134453-8	2019	Upregulation of Fatty acid synthase (Fasn) and Adipose triglyceride lipase (Atgl/Pnpla2) by obestatin were reversed by both capsaicin and genistein.	Capsaicin	124-133	patatin-like phospholipase domain containing 2	Mus musculus	47-74
31134453-8	2019	Upregulation of Fatty acid synthase (Fasn) and Adipose triglyceride lipase (Atgl/Pnpla2) by obestatin were reversed by both capsaicin and genistein.	Capsaicin	124-133	patatin-like phospholipase domain containing 2	Mus musculus	76-80
31134453-8	2019	Upregulation of Fatty acid synthase (Fasn) and Adipose triglyceride lipase (Atgl/Pnpla2) by obestatin were reversed by both capsaicin and genistein.	Capsaicin	124-133	patatin-like phospholipase domain containing 2	Mus musculus	81-87
31134453-10	2019	Over expression of the lipases and UCP1 in case of capsaicin could be resulting in net lowering of lipid accumulation in the cells.	Capsaicin	51-60	uncoupling protein 1 (mitochondrial, proton carrier)	Mus musculus	35-39
31340396-6	2019	From the permeation results, it was clear that capsaicin inhibited P-glycoprotein efflux to a larger extent, while piperine showed drug permeation enhancement via other mechanisms.	Capsaicin	47-56	ATP binding cassette subfamily B member 1	Homo sapiens	67-81
31399015-5	2019	Expert opinion: The therapeutic effect of TRPV1 channel desensitizing agonists (capsaicin, resiniferatoxin, given intravesically) has been convincingly demonstrated in some forms of bladder overactivity.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
31471389-7	2019	Capsaicin (a TRPV1 agonist) increased insulin secretion in WT, but not in TRPV1-/- mice.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	13-18
31075226-3	2019	Capsaicin, a TRPV1 agonist, can initiate activity in myenteric neurons and produce muscle contraction.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	13-18
31253755-6	2019	Using capsaicin as a sensitizing stimulus, we show that behavioral responses are greater in the TG region and this effect is completely reversible with mTOR inhibition.	Capsaicin	6-15	mechanistic target of rapamycin kinase	Mus musculus	152-156
31343160-1	2019	The sensory nervous system controls cardiovascular homeostasis via capsaicin-sensitive neurons that release calcitonin gene-related peptide (CGRP), which subsequently activates CGRP receptors.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	108-139
31343160-1	2019	The sensory nervous system controls cardiovascular homeostasis via capsaicin-sensitive neurons that release calcitonin gene-related peptide (CGRP), which subsequently activates CGRP receptors.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	141-145
31343160-1	2019	The sensory nervous system controls cardiovascular homeostasis via capsaicin-sensitive neurons that release calcitonin gene-related peptide (CGRP), which subsequently activates CGRP receptors.	Capsaicin	67-76	calcitonin-related polypeptide alpha	Rattus norvegicus	177-181
31324733-0	2019	Capsaicin inhibits the migration and invasion via the AMPK/NF-kappaB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	54-58
31324733-0	2019	Capsaicin inhibits the migration and invasion via the AMPK/NF-kappaB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	59-68
31324733-0	2019	Capsaicin inhibits the migration and invasion via the AMPK/NF-kappaB signaling pathway in esophagus sequamous cell carcinoma by decreasing matrix metalloproteinase-9 expression.	Capsaicin	0-9	matrix metallopeptidase 9	Homo sapiens	139-165
31324733-6	2019	In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	sirtuin 1	Homo sapiens	35-43
31324733-6	2019	In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	sirtuin 1	Homo sapiens	45-50
31324733-6	2019	In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	85-106
31324733-6	2019	In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	nuclear factor kappa B subunit 1	Homo sapiens	108-117
31324733-6	2019	In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	155-159
31324733-6	2019	In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	NFKB inhibitor alpha	Homo sapiens	192-204
31324733-6	2019	In addition, capsaicin can enhance sirtuin1 (SIRT1) expression, which could activate nuclear factor-kappaB (NF-kappaB) through deacetylation, and activate AMPK inducing the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	233-246
31324733-7	2019	Overall, these results revealed that Capsaicin can inhibit the migration and invasion of ESCC cells via the AMPK/NF-kappaB signaling pathway.	Capsaicin	37-46	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	108-112
31324733-7	2019	Overall, these results revealed that Capsaicin can inhibit the migration and invasion of ESCC cells via the AMPK/NF-kappaB signaling pathway.	Capsaicin	37-46	nuclear factor kappa B subunit 1	Homo sapiens	113-122
30993920-12	2019	HFD+curcumin+capsaicin caused decreased BAX, caspase-3, TOS, and ROS levels as compared to HFD, but increased TAS and Bcl-2.	Capsaicin	13-22	BCL2 associated X, apoptosis regulator	Rattus norvegicus	40-43
30993920-12	2019	HFD+curcumin+capsaicin caused decreased BAX, caspase-3, TOS, and ROS levels as compared to HFD, but increased TAS and Bcl-2.	Capsaicin	13-22	caspase 3	Rattus norvegicus	45-54
30993920-12	2019	HFD+curcumin+capsaicin caused decreased BAX, caspase-3, TOS, and ROS levels as compared to HFD, but increased TAS and Bcl-2.	Capsaicin	13-22	BCL2, apoptosis regulator	Rattus norvegicus	118-123
30632627-0	2019	Pharmacokinetic effects of capsaicin on vinblastine in rats mediated by CYP3A and Mrp2.	Capsaicin	27-36	cytochrome P450, family 3, subfamily a, polypeptide 62	Rattus norvegicus	72-77
31194993-8	2019	The results also showed that TRPV1 agonist, Capsaicin boosted the SIRT6-induced glucose uptake, CGRP production, and GLUT4 levels.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
31194993-8	2019	The results also showed that TRPV1 agonist, Capsaicin boosted the SIRT6-induced glucose uptake, CGRP production, and GLUT4 levels.	Capsaicin	44-53	sirtuin 6	Mus musculus	66-71
31194993-8	2019	The results also showed that TRPV1 agonist, Capsaicin boosted the SIRT6-induced glucose uptake, CGRP production, and GLUT4 levels.	Capsaicin	44-53	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	96-100
31194993-8	2019	The results also showed that TRPV1 agonist, Capsaicin boosted the SIRT6-induced glucose uptake, CGRP production, and GLUT4 levels.	Capsaicin	44-53	solute carrier family 2 (facilitated glucose transporter), member 4	Mus musculus	117-122
30632627-0	2019	Pharmacokinetic effects of capsaicin on vinblastine in rats mediated by CYP3A and Mrp2.	Capsaicin	27-36	ATP binding cassette subfamily C member 2	Rattus norvegicus	82-86
31279897-0	2019	Novel design of NIR-triggered plasmonic nanodots capped mesoporous silica nanoparticles loaded with natural capsaicin to inhibition of metastasis of human papillary thyroid carcinoma B-CPAP cells in thyroid cancer chemo-photothermal therapy.	Capsaicin	108-117	NOC2 like nucleolar associated transcriptional repressor	Homo sapiens	16-19
31279897-6	2019	3-(4, 5-Dimethyl-2-thiazolyl)-2, 5-diphenyl-2H tetrazolium bromide (MTT) assay determined that capsaicin and Cap-AuMSNs conferred strong cytotoxicity against the FTC-133 and B-CPAP cell lines.	Capsaicin	95-104	centromere protein J	Homo sapiens	176-180
31279897-0	2019	Novel design of NIR-triggered plasmonic nanodots capped mesoporous silica nanoparticles loaded with natural capsaicin to inhibition of metastasis of human papillary thyroid carcinoma B-CPAP cells in thyroid cancer chemo-photothermal therapy.	Capsaicin	108-117	centromere protein J	Homo sapiens	185-189
31075088-12	2019	For mechanical stimuli, NRS was increased following capsaicin (LMM, p &lt; 0.001).	Capsaicin	52-61	sphingolipid transporter 1 (putative)	Homo sapiens	24-27
31242552-1	2019	Capsaicin-Sensitive Sensory Nerves Are Necessary for the Protective Effect of Ghrelin in Cerulein-Induced Acute Pancreatitis in Rats.	Capsaicin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	78-85
31316714-0	2019	Oral supplementation with capsaicin reduces oxidative stress and IL-33 on a food allergy murine model.	Capsaicin	26-35	interleukin 33	Mus musculus	65-70
31316714-10	2019	However, macrophages infiltration and IL-33 in proximal jejunum was reduced in OVA capsaicin group.	Capsaicin	83-92	interleukin 33	Mus musculus	38-43
30993812-6	2019	On the other hand, attenuation of neuropeptide levels with capsaicin was found to significantly inhibit lens regeneration, as visualized by a reduction of Substance P.	Capsaicin	59-68	tachykinin precursor 1 L homeolog	Xenopus laevis	155-166
31026506-4	2019	When expressed by sensory neurons, activation of TRPV1 channels by heat (>40  C), capsaicin (sub-micromolar), or acid environment (pH < 6), causes depolarization leading to burning pain sensation in mammals.	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
31009639-0	2019	Oral gavage of capsaicin causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity in the mouse.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	32-37
31009639-0	2019	Oral gavage of capsaicin causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity in the mouse.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	70-75
31009639-1	2019	Capsaicin (CAP), the pungent ingredient of hot red pepper, is a selective ligand for the heat-sensitive transient receptor potential V1 cation channel 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	154-159
31009639-1	2019	Capsaicin (CAP), the pungent ingredient of hot red pepper, is a selective ligand for the heat-sensitive transient receptor potential V1 cation channel 1 (TRPV1).	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	154-159
31009639-5	2019	Moreover, a long-lasting increase of locomotor activity was observed in both WT and TRPV1 KO mice after oral gavage of CAP, but increase in core body temperature was seen only in TRPV1 KO animals.	Capsaicin	119-122	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	84-89
31009639-6	2019	Oral gavage of CAP induced neuronal Fos expression in the circumventricular organs, median and medial preoptic area, arcuate nucleus, and nucleus of the solitary tract, whereas neuronal Fos expression was scarcely observed in TRPV1 KO mice.	Capsaicin	15-18	FBJ osteosarcoma oncogene	Mus musculus	36-39
31009639-6	2019	Oral gavage of CAP induced neuronal Fos expression in the circumventricular organs, median and medial preoptic area, arcuate nucleus, and nucleus of the solitary tract, whereas neuronal Fos expression was scarcely observed in TRPV1 KO mice.	Capsaicin	15-18	FBJ osteosarcoma oncogene	Mus musculus	186-189
31009639-6	2019	Oral gavage of CAP induced neuronal Fos expression in the circumventricular organs, median and medial preoptic area, arcuate nucleus, and nucleus of the solitary tract, whereas neuronal Fos expression was scarcely observed in TRPV1 KO mice.	Capsaicin	15-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	226-231
31009639-7	2019	Thus, the present study demonstrates in the mice that oral intake of CAP causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity, and moreover activates the brain circuits controlling thermoregulation and metabolism.	Capsaicin	69-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	80-85
31009639-7	2019	Thus, the present study demonstrates in the mice that oral intake of CAP causes TRPV1-dependent acute hypothermia and TRPV1-independent long-lasting increase of locomotor activity, and moreover activates the brain circuits controlling thermoregulation and metabolism.	Capsaicin	69-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	118-123
31261824-4	2019	The apoptotic-inducing activity of capsaicin was further confirmed by Annexin V-Fluorescein isothiocyanate / Propidium iodide (V-FITC/PI) staining using flow cytometry.	Capsaicin	35-44	annexin A5	Homo sapiens	70-79
31261824-8	2019	Apoptosis of capsaicin-treated ORL-48 cells revealed disruption of the mitochondrial-membrane potential, activation of caspase-3, -7 and -9 through an intrinsic apoptotic pathway and subsequently, apoptotic DNA fragmentation.	Capsaicin	13-22	caspase 3	Homo sapiens	119-139
30898677-7	2019	The effect of capsaicin was completely abolished by a TRPV1 channel blocker AMG9810 (0.1 muM).	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
30927254-5	2019	KEY RESULTS: The classical TRPV1 agonist capsaicin as well as TRPV1 antagonists A-889425, BCTC, and capsazepine directly inhibited Cav 3 channels.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
30927254-5	2019	KEY RESULTS: The classical TRPV1 agonist capsaicin as well as TRPV1 antagonists A-889425, BCTC, and capsazepine directly inhibited Cav 3 channels.	Capsaicin	41-50	caveolin 3	Rattus norvegicus	131-136
31197191-1	2019	Capsaicin (CAP) activates transient receptor potential vanilloid subfamily 1 (TRPV1) to counter high-fat diet (HFD)-induced obesity.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	26-76
31197191-1	2019	Capsaicin (CAP) activates transient receptor potential vanilloid subfamily 1 (TRPV1) to counter high-fat diet (HFD)-induced obesity.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
31197191-1	2019	Capsaicin (CAP) activates transient receptor potential vanilloid subfamily 1 (TRPV1) to counter high-fat diet (HFD)-induced obesity.	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	26-76
31197191-1	2019	Capsaicin (CAP) activates transient receptor potential vanilloid subfamily 1 (TRPV1) to counter high-fat diet (HFD)-induced obesity.	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
30969886-0	2019	Dry eye sensitizes cool cells to capsaicin-induced changes in activity via TRPV1.	Capsaicin	33-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	75-80
31186372-2	2019	Studies on the internalization of TRPV1 have mainly focused on that induced by capsaicin or other agonists.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	34-39
31195742-6	2019	It is interesting to note that structural changes in capsaicin derivatives had higher impacts on alpha-glucosidase than on alpha-amylase inhibition.	Capsaicin	53-62	sucrase-isomaltase	Homo sapiens	97-114
30938826-5	2019	In CP-W, pinprick hyperalgesia and increased sensitivity to capsaicin were aligned with increased epidermal TRPV1 expression, while smaller histamine axon reflex erythema matched with significantly reduced intraepidermal nerve fiber density.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	108-113
30938826-6	2019	CP-N showed earlier onset of sensations after capsaicin stimulation, significantly increased warmth detection threshold, and higher epidermal expression of TRPV4 compared to healthy controls.	Capsaicin	46-55	carboxypeptidase N subunit 1	Homo sapiens	0-4
30830967-11	2019	In the DRG, MaR1 reduced CFA-induced Nav1.8 and Trpv1 mRNA expression and calcium influx and capsaicin-induced release of CGRP by DRG neurons.	Capsaicin	93-102	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	122-126
31075194-0	2019	Combination of Capsaicin and Capsiate Induces Browning in 3T3-L1 White Adipocytes via Activation of the Peroxisome Proliferator-Activated Receptor gamma/beta3-Adrenergic Receptor Signaling Pathways.	Capsaicin	15-24	peroxisome proliferator activated receptor gamma	Homo sapiens	104-152
31075194-0	2019	Combination of Capsaicin and Capsiate Induces Browning in 3T3-L1 White Adipocytes via Activation of the Peroxisome Proliferator-Activated Receptor gamma/beta3-Adrenergic Receptor Signaling Pathways.	Capsaicin	15-24	adrenoceptor beta 3	Homo sapiens	153-178
31075194-7	2019	In conclusion, these results indicated that a combination of capsaicin and capsiate could induce browning in white adipocytes via activation of the PPARgamma/beta3-AR signaling pathway, and this combination might be worth investigating as a potential cure for obesity.	Capsaicin	61-70	peroxisome proliferator activated receptor gamma	Homo sapiens	148-157
31075194-7	2019	In conclusion, these results indicated that a combination of capsaicin and capsiate could induce browning in white adipocytes via activation of the PPARgamma/beta3-AR signaling pathway, and this combination might be worth investigating as a potential cure for obesity.	Capsaicin	61-70	adrenoceptor beta 3	Homo sapiens	158-166
30936039-1	2019	The Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin, low pH and noxious heat.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-68
30936039-1	2019	The Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a non-selective cation channel that is activated by capsaicin, low pH and noxious heat.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	70-75
30936039-5	2019	A novel, in vivo, electrophysiological bone-nerve preparation, recently developed in our laboratory, was used to make recordings of the activity and sensitivity of bone afferent neurons in response to application of the TRPV1 agonist capsaicin to the marrow cavity.	Capsaicin	234-243	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	220-225
31095448-0	2019	Capsaicin induces cytotoxicity in human osteosarcoma MG63 cells through TRPV1-dependent and -independent pathways.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
31095448-4	2019	We found that capsaicin-induced apoptosis and the activation of transient receptor potential receptor vanilloid 1 (TRPV1) in a dose- and time-dependent manner in human osteosarcoma MG63 cells in vitro.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-113
31095448-4	2019	We found that capsaicin-induced apoptosis and the activation of transient receptor potential receptor vanilloid 1 (TRPV1) in a dose- and time-dependent manner in human osteosarcoma MG63 cells in vitro.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	115-120
31095448-5	2019	Blocking TRPV1 using capsazepine attenuated the capsaicin-induced cytotoxicity, mitochondrial dysfunction, overproduction of reactive oxygen species (ROS) and decrease in superoxide dismutase (SOD) activity.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-14
31095448-5	2019	Blocking TRPV1 using capsazepine attenuated the capsaicin-induced cytotoxicity, mitochondrial dysfunction, overproduction of reactive oxygen species (ROS) and decrease in superoxide dismutase (SOD) activity.	Capsaicin	48-57	superoxide dismutase 1	Homo sapiens	171-191
31095448-5	2019	Blocking TRPV1 using capsazepine attenuated the capsaicin-induced cytotoxicity, mitochondrial dysfunction, overproduction of reactive oxygen species (ROS) and decrease in superoxide dismutase (SOD) activity.	Capsaicin	48-57	superoxide dismutase 1	Homo sapiens	193-196
31095448-6	2019	In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK).	Capsaicin	43-52	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	79-130
31095448-6	2019	In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK).	Capsaicin	43-52	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	132-136
31095448-6	2019	In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK).	Capsaicin	43-52	tumor protein p53	Homo sapiens	139-142
31095448-6	2019	In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK).	Capsaicin	43-52	mitogen-activated protein kinase 8	Homo sapiens	147-170
31095448-6	2019	In addition, the results demonstrated that capsaicin induced the activation of adenosine 5"-monophosphate-activated protein kinase (AMPK), p53 and C-jun N-terminal kinase (JNK).	Capsaicin	43-52	mitogen-activated protein kinase 8	Homo sapiens	172-175
31095448-8	2019	Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-148
31095448-8	2019	Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways.	Capsaicin	48-57	mitogen-activated protein kinase 8	Homo sapiens	217-220
31095448-8	2019	Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	226-231
31095448-8	2019	Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways.	Capsaicin	48-57	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	245-249
31095448-8	2019	Taken together, the present study suggests that capsaicin effectively causes cell death in human osteosarcoma MG63 cells via the activation of TRPV1-dependent (mitochondrial dysfunction, and overproduction of ROS and JNK) and TRPV1-independent (AMPK-p53) pathways.	Capsaicin	48-57	tumor protein p53	Homo sapiens	250-253
30969886-3	2019	In the present study, we examined the effect of dry eye on the sensitivity of cool cells to the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin.	Capsaicin	153-162	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-136
30969886-3	2019	In the present study, we examined the effect of dry eye on the sensitivity of cool cells to the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin.	Capsaicin	153-162	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	138-143
30969886-9	2019	Capsaicin-induced changes were prevented by the application of the TRPV1 antagonist capsazepine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-72
30904671-1	2019	Capsaicin is an agonist for transient receptor potential vanilloid 1 (TRPV1), and acute injection results in an increased frequency and tidal volume in young rats.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	28-68
31186689-8	2019	Additionally, the formation of autophagosomes and accumulation of microtubule-associated proteins 1A/1B light chain 3B-II and beclin 1 suggested that capsaicin induced autophagy in human melanoma cells.	Capsaicin	150-159	beclin 1	Homo sapiens	126-134
31186689-9	2019	Furthermore, inhibiting capsaicin-induced autophagy promoted the activation of cleaved caspase-3 and PARP proteins, which are associated with apoptosis.	Capsaicin	24-33	caspase 3	Homo sapiens	87-96
31186689-9	2019	Furthermore, inhibiting capsaicin-induced autophagy promoted the activation of cleaved caspase-3 and PARP proteins, which are associated with apoptosis.	Capsaicin	24-33	poly(ADP-ribose) polymerase 1	Homo sapiens	101-105
30904671-1	2019	Capsaicin is an agonist for transient receptor potential vanilloid 1 (TRPV1), and acute injection results in an increased frequency and tidal volume in young rats.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	70-75
31263706-6	2019	TRPV1 can be activated by a large array of physical (heat, mechanical stimuli) and chemical factors (e.g., protons, capsaicin, resiniferatoxin, and endogenous ligands, such as endovanilloids).	Capsaicin	116-125	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
31217872-3	2019	Capsaicin, a selective agonist of the transient potential vanilloid subfamily member 1 (TRPV1) receptor, exhibits anti-inflammatory effects on various causes of inflammation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	88-93
30672650-7	2019	In addition, heat acclimation attenuated the capsaicin-induced activation of ERK.	Capsaicin	45-54	mitogen-activated protein kinase 1	Homo sapiens	77-80
30819813-8	2019	Geometric mean+-sd capsaicin dose thresholds for five coughs with (CS5) and without (C5) suppression attempts were 254.40+-3.78 versus 45.89+-3.95 micromol L-1, respectively, in healthy controls (p=0.033) and 3.34+-5.04 versus 3.86+-5.13 micromol L-1, respectively, in participants with chronic refractory cough (p=0.922).	Capsaicin	19-28	chorionic somatomammotropin hormone like 1	Homo sapiens	67-70
30819813-11	2019	CS5 was associated with objective cough frequency (rho=-0.514, p=0.029).Participants with chronic refractory cough were less able to voluntarily suppress capsaicin-evoked cough compared to healthy controls.	Capsaicin	154-163	chorionic somatomammotropin hormone like 1	Homo sapiens	0-3
30560330-12	2019	SLIGRL-NH2, a PAR2 agonist, and capsaicin, a TRPV1 agonist, blocked the effects of probiotic VSL#3.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	45-50
30672650-8	2019	Heat acclimation may induce capsaicin tolerance via the downregulation of TRPV1.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
31183372-8	2019	Then, we found that the TRVP1 agonist capsaicin treatment inhibited CRC growth and induced apoptosis by activating P53.	Capsaicin	38-47	tumor protein p53	Homo sapiens	115-118
30670776-4	2019	Such phenotypic characteristics are highly similar to those of mice lacking Trpv1, which encodes the cation channel involved in capsaicin-stimulated Ca2+ influx.	Capsaicin	128-137	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	76-81
30768945-7	2019	By using our novel cluster analysis of pain spikes, we demonstrated that 42% of fibers responded to Piezo1 agonist and 20% of trigeminal fibers were activated by Yoda1 and by capsaicin, suggesting expression of Piezo receptors in TRPV1 positive peptidergic nociceptive nerve fibers.	Capsaicin	175-184	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	230-235
30987128-9	2019	Furthermore, capsaicin blocked autophagy and increased PGC-1alpha protein.	Capsaicin	13-22	PPARG coactivator 1 alpha	Homo sapiens	55-65
31068978-2	2019	The aim of this proof-of-concept study was to assess the biomechanical and neurophysiological effects of acute and subacute oropharyngeal sensory stimulation with transient receptor potential vanilloid 1 (TRPV1) agonists (capsaicinoids) in older patients with OD.	Capsaicin	222-235	transient receptor potential cation channel subfamily V member 1	Homo sapiens	163-203
30987128-0	2019	Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	53-57
31139213-12	2019	Preincubation of DRG neurones with tesaglitazar 6 hours prior to stimulation with capsaicin significantly reduce capsaicin-evoked cobalt responses in a PPARalpha and PPARgamma dependent fashion (P&lt;0.05).	Capsaicin	82-91	peroxisome proliferator activated receptor alpha	Rattus norvegicus	152-161
31139213-12	2019	Preincubation of DRG neurones with tesaglitazar 6 hours prior to stimulation with capsaicin significantly reduce capsaicin-evoked cobalt responses in a PPARalpha and PPARgamma dependent fashion (P&lt;0.05).	Capsaicin	82-91	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	166-175
31139213-12	2019	Preincubation of DRG neurones with tesaglitazar 6 hours prior to stimulation with capsaicin significantly reduce capsaicin-evoked cobalt responses in a PPARalpha and PPARgamma dependent fashion (P&lt;0.05).	Capsaicin	113-122	peroxisome proliferator activated receptor alpha	Rattus norvegicus	152-161
31139213-12	2019	Preincubation of DRG neurones with tesaglitazar 6 hours prior to stimulation with capsaicin significantly reduce capsaicin-evoked cobalt responses in a PPARalpha and PPARgamma dependent fashion (P&lt;0.05).	Capsaicin	113-122	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	166-175
30987128-0	2019	Capsaicin Targets Lipogenesis in HepG2 Cells Through AMPK Activation, AKT Inhibition and PPARs Regulation.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	70-73
30793318-10	2019	We found that S1P in the lungs strongly activated 81.5% of nodose fibres, 70% of which were also activated by capsaicin.	Capsaicin	110-119	sphingosine-1-phosphate receptor 1	Mus musculus	14-17
30987128-7	2019	This effect of capsaicin was prevented by dorsomorphin and GW9662, pharmacological inhibitors of AMPK and PPARgamma, respectively.	Capsaicin	15-24	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	97-101
30987128-7	2019	This effect of capsaicin was prevented by dorsomorphin and GW9662, pharmacological inhibitors of AMPK and PPARgamma, respectively.	Capsaicin	15-24	peroxisome proliferator activated receptor gamma	Homo sapiens	106-115
30987128-8	2019	In addition, capsaicin activated AMPK and inhibited the AKT/mTOR pathway, major regulators of hepatic lipogenesis.	Capsaicin	13-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	33-37
30987128-8	2019	In addition, capsaicin activated AMPK and inhibited the AKT/mTOR pathway, major regulators of hepatic lipogenesis.	Capsaicin	13-22	AKT serine/threonine kinase 1	Homo sapiens	56-59
30987128-8	2019	In addition, capsaicin activated AMPK and inhibited the AKT/mTOR pathway, major regulators of hepatic lipogenesis.	Capsaicin	13-22	mechanistic target of rapamycin kinase	Homo sapiens	60-64
31138996-0	2019	Delayed Treatment of Capsaicin Produces Partial Motor Recovery by Enhancing Dopamine Function in MPP+-lesioned Rats via Ciliary Neurotrophic Factor.	Capsaicin	21-30	ciliary neurotrophic factor	Rattus norvegicus	120-147
31138996-4	2019	TRPV1 agonist, capsaicin (CAP), was intraperitoneally administered.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
30676422-14	2019	By contrast, the TRPV1 agonist capsaicin (3 muM) produced a weaker potentiation in Withdrawn than Naive rats (spontaneous excitatory postsynaptic currents: by 203.6 +- 124.7% [n = 20] vs. 415.2 +- 424.3% [n = 15], P < 0.001; firing: 38.1 +- 14.7% [n = 11] vs. 73.9 +- 41.9% [n = 11], P < 0.001).	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	17-22
30676422-15	2019	Conversely, capsaicin"s actions in Naive but not in Withdrawn rats were significantly attenuated by the pretreatment of TRPV1 endogenous agonist N-Oleoyldopamine.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
30729424-3	2019	OBJECTIVE: The aim of this study was to investigate if capsaicin, an activator of TRPV1, would prevent LPS-induced glucocorticoid production by adrenals.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	82-87
30785813-0	2019	Capsaicin causes robust reduction in glycinergic transmission to rat hypoglossal motor neurons via a TRPV1-independent mechanism.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-106
30785813-3	2019	In the presence of capsazepine, a classic TRPV1 antagonist, capsaicin was still able to reduce spontaneous inhibitory postsynaptic current (IPSC) amplitude and frequency.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
30935063-2	2019	Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation.	Capsaicin	113-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
30935063-2	2019	Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation.	Capsaicin	113-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
30935063-2	2019	Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation.	Capsaicin	113-122	ankyrin 1	Homo sapiens	53-62
30935063-2	2019	Transient receptor potential vanilloid 1 (TRPV1) and ankyrin 1 (TRPA1) ion channels located predominantly on the capsaicin-sensitive sensory neurons play a complex role in hyperalgesia and neurogenic inflammation.	Capsaicin	113-122	transient receptor potential cation channel subfamily A member 1	Homo sapiens	64-69
30871017-1	2019	Capsazepine is a synthetic analogue of capsaicin that can function as an antagonist of TRPV1.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
30897864-24	2019	(5) Compared with 0.99+-0.04 and 0.54+-0.04 in simple hypoxia group, the protein expressions of LAMP-1 and LAMP-2 in hypoxia+ 10.0 mumol/L capsaicin group were significantly increased (1.49+-0.06, 0.81+-0.05, t=12.550, 7.442, P&lt;0.01).	Capsaicin	139-148	lysosomal-associated membrane protein 1	Mus musculus	96-102
30897864-24	2019	(5) Compared with 0.99+-0.04 and 0.54+-0.04 in simple hypoxia group, the protein expressions of LAMP-1 and LAMP-2 in hypoxia+ 10.0 mumol/L capsaicin group were significantly increased (1.49+-0.06, 0.81+-0.05, t=12.550, 7.442, P&lt;0.01).	Capsaicin	139-148	lysosomal-associated membrane protein 2	Mus musculus	107-113
31160978-0	2019	Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	54-57
31160978-0	2019	Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells.	Capsaicin	0-9	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	75-112
31160978-0	2019	Capsaicin enhances erlotinib-induced cytotoxicity via AKT inactivation and excision repair cross-complementary 1 (ERCC1) down-regulation in human lung cancer cells.	Capsaicin	0-9	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	114-119
31160978-4	2019	However, whether capsaicin and erlotinib could induce synergistic cytotoxicity in NSCLC cells through modulating ERCC1 expression is unknown.	Capsaicin	17-26	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	113-118
30858408-5	2019	Here we report that direct TRPV1 activation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevents cisplatin ototoxicity by sustained increased activation of pro-survival transcription factor signal transducer and activator of transcription (STAT3) in the Wistar rat.	Capsaicin	103-112	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	114-119
31160978-5	2019	In this study, capsaicin decreased the ERCC1 expression in an AKT inactivation dependent manner in two human lung adenocarcinoma cells, namely, A549 and H1975.	Capsaicin	15-24	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	39-44
30858408-5	2019	Here we report that direct TRPV1 activation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevents cisplatin ototoxicity by sustained increased activation of pro-survival transcription factor signal transducer and activator of transcription (STAT3) in the Wistar rat.	Capsaicin	103-112	signal transducer and activator of transcription 3	Rattus norvegicus	281-286
30858408-0	2019	Capsaicin Protects Against Cisplatin Ototoxicity by Changing the STAT3/STAT1 Ratio and Activating Cannabinoid (CB2) Receptors in the Cochlea.	Capsaicin	0-9	signal transducer and activator of transcription 3	Rattus norvegicus	65-70
31160978-5	2019	In this study, capsaicin decreased the ERCC1 expression in an AKT inactivation dependent manner in two human lung adenocarcinoma cells, namely, A549 and H1975.	Capsaicin	15-24	AKT serine/threonine kinase 1	Homo sapiens	62-65
30858408-0	2019	Capsaicin Protects Against Cisplatin Ototoxicity by Changing the STAT3/STAT1 Ratio and Activating Cannabinoid (CB2) Receptors in the Cochlea.	Capsaicin	0-9	signal transducer and activator of transcription 1	Rattus norvegicus	71-76
30858408-7	2019	Our data indicate that capsaicin causes a transient STAT1 activation via TRPV1 activation, responsible for the previously reported temporary threshold shift.	Capsaicin	23-32	signal transducer and activator of transcription 1	Rattus norvegicus	52-57
31160978-6	2019	Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the ERCC1 protein level as well as the cell survival by capsaicin.	Capsaicin	147-156	AKT serine/threonine kinase 1	Homo sapiens	15-18
30858408-7	2019	Our data indicate that capsaicin causes a transient STAT1 activation via TRPV1 activation, responsible for the previously reported temporary threshold shift.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	73-78
30858408-1	2019	Capsaicin, the spicy component of hot chili peppers activates the TRPV1 pain receptors, and causes rapid desensitization.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
31160978-6	2019	Enhancement of AKT activity by transfection with constitutive active AKT vectors increased the ERCC1 protein level as well as the cell survival by capsaicin.	Capsaicin	147-156	AKT serine/threonine kinase 1	Homo sapiens	69-72
30858408-5	2019	Here we report that direct TRPV1 activation by localized trans-tympanic (TT) or oral administration of capsaicin (TRPV1 agonist) prevents cisplatin ototoxicity by sustained increased activation of pro-survival transcription factor signal transducer and activator of transcription (STAT3) in the Wistar rat.	Capsaicin	103-112	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
30858408-8	2019	Additionally, we found that capsaicin increased cannabinoid receptor (CB2) in the cochlea, which leads to pro-survival Tyr705-p-STAT3 activation.	Capsaicin	28-37	cannabinoid receptor 2	Rattus norvegicus	70-73
30858408-8	2019	Additionally, we found that capsaicin increased cannabinoid receptor (CB2) in the cochlea, which leads to pro-survival Tyr705-p-STAT3 activation.	Capsaicin	28-37	signal transducer and activator of transcription 3	Rattus norvegicus	128-133
31160978-7	2019	Moreover, capsaicin synergistically enhanced the cytotoxicity and cell growth inhibition of erlotinib in NSCLC cells, which were associated with the down-regulation of ERCC1 expression and inactivation of AKT in A549 and H1975 cells.	Capsaicin	10-19	ERCC excision repair 1, endonuclease non-catalytic subunit	Homo sapiens	168-173
30858408-10	2019	Furthermore, capsaicin mediated protection is lost when CB2 antagonist AM630 is administered prior to capsaicin treatment.	Capsaicin	13-22	cannabinoid receptor 2	Rattus norvegicus	56-59
30858408-11	2019	In conclusion, capsaicin otoprotection appears to be mediated by activation of CB2 receptors in the cochlea which are coupled to both STAT1 and STAT3 activation.	Capsaicin	15-24	cannabinoid receptor 2	Rattus norvegicus	79-82
30858408-11	2019	In conclusion, capsaicin otoprotection appears to be mediated by activation of CB2 receptors in the cochlea which are coupled to both STAT1 and STAT3 activation.	Capsaicin	15-24	signal transducer and activator of transcription 1	Rattus norvegicus	134-139
30858408-11	2019	In conclusion, capsaicin otoprotection appears to be mediated by activation of CB2 receptors in the cochlea which are coupled to both STAT1 and STAT3 activation.	Capsaicin	15-24	signal transducer and activator of transcription 3	Rattus norvegicus	144-149
31160978-7	2019	Moreover, capsaicin synergistically enhanced the cytotoxicity and cell growth inhibition of erlotinib in NSCLC cells, which were associated with the down-regulation of ERCC1 expression and inactivation of AKT in A549 and H1975 cells.	Capsaicin	10-19	AKT serine/threonine kinase 1	Homo sapiens	205-208
30899201-16	2019	In addition, pharmacological inhibition of AMPK with dorsomorphin (compound C) as well as knock down by siRNA of AMPK or its upstream kinase LKB1, abolished the synergy of docetaxel and capsaicin.	Capsaicin	186-195	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	43-47
30899201-0	2019	Combination of the natural product capsaicin and docetaxel synergistically kills human prostate cancer cells through the metabolic regulator AMP-activated kinase.	Capsaicin	35-44	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	141-161
30899201-16	2019	In addition, pharmacological inhibition of AMPK with dorsomorphin (compound C) as well as knock down by siRNA of AMPK or its upstream kinase LKB1, abolished the synergy of docetaxel and capsaicin.	Capsaicin	186-195	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	113-117
30899201-13	2019	Co-treatment with docetaxel and capsaicin notably decreased Akt and its downstream targets mTOR and S6 phosphorylation.	Capsaicin	32-41	AKT serine/threonine kinase 1	Homo sapiens	60-63
30899201-16	2019	In addition, pharmacological inhibition of AMPK with dorsomorphin (compound C) as well as knock down by siRNA of AMPK or its upstream kinase LKB1, abolished the synergy of docetaxel and capsaicin.	Capsaicin	186-195	serine/threonine kinase 11	Homo sapiens	141-145
30899201-13	2019	Co-treatment with docetaxel and capsaicin notably decreased Akt and its downstream targets mTOR and S6 phosphorylation.	Capsaicin	32-41	mechanistic target of rapamycin kinase	Homo sapiens	91-95
30653947-6	2019	However, vasodilation in response to capsaicin (100 nM), a sensory nerve activator used to release perivascular CGRP, was significantly reduced by SAH (P = 0.0079).	Capsaicin	37-46	calcitonin-related polypeptide alpha	Rattus norvegicus	112-116
30899201-14	2019	Overexpression of PTEN phosphatase abrogated the synergistic antiproliferative effect of docetaxel and capsaicin.	Capsaicin	103-112	phosphatase and tensin homolog	Homo sapiens	18-22
30152861-8	2019	Moreover, there was a significant increase in the expression of COX-2-positive cells in the Vc of capsaicin-treated rats (P &lt; 0.01).	Capsaicin	98-107	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	64-69
29991708-9	2019	The capsaicin-induced aversion in the plus-maze test was enhanced by WIN55212-2 and blocked by pretreatment with vanilloid antagonist capsazepine or the CB1 receptor antagonist rimonabant, demonstrating an interaction between the endocannabinoid and endovanilloid systems in CNS.	Capsaicin	4-13	cannabinoid receptor 1 (brain)	Mus musculus	153-156
30152877-9	2019	RESULTS: Orexin-A dose-dependently decreased capsaicin-induced nociceptive behaviour.	Capsaicin	45-54	hypocretin neuropeptide precursor	Rattus norvegicus	9-17
30152877-12	2019	Capsaicin-induced changes in SP levels, however, were prohibited by orexin-A treatment (150 pmol L-1 ) (P &lt; 0.05).	Capsaicin	0-9	hypocretin neuropeptide precursor	Rattus norvegicus	68-76
30152877-13	2019	CONCLUSIONS: Orexin-A administration into the vlPAG was associated with an inhibitory effect on capsaicin-induced pulpal nociception and bidirectional effects on the induction of SP in vlPAG and Vc of rats.	Capsaicin	96-105	hypocretin neuropeptide precursor	Rattus norvegicus	13-21
30159798-2	2019	In addition to the actions of capsaicin (CAP) and reactive oxygen species (ROS), the TRPV1 channel is activated in neurons by endogenous cannabinoid, anandamide (AEA).	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-90
30159798-2	2019	In addition to the actions of capsaicin (CAP) and reactive oxygen species (ROS), the TRPV1 channel is activated in neurons by endogenous cannabinoid, anandamide (AEA).	Capsaicin	41-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-90
30159798-10	2019	Possible molecular pathways of involvement of capsazepine (CPZ) and AM4040 in anandamide and capsaicin (CAP)-induced apoptosis, oxidative stress, and Ca2+ accumulation through TRPV1 channel in the seizure-induced rat hippocampus and human glioblastoma neurons.	Capsaicin	93-102	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	176-181
30159798-10	2019	Possible molecular pathways of involvement of capsazepine (CPZ) and AM4040 in anandamide and capsaicin (CAP)-induced apoptosis, oxidative stress, and Ca2+ accumulation through TRPV1 channel in the seizure-induced rat hippocampus and human glioblastoma neurons.	Capsaicin	104-107	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	176-181
30159798-11	2019	The TRPV1 channel is activated by different stimuli including reactive oxygen species (ROS), anandamide (AEA), and CAP and it is blocked by capsazepine (CPZ).	Capsaicin	115-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
30795543-5	2019	Although TRPV1 expressing neuron percentage was increased in Ins2+/Akita DRGs at 9 months of diabetes compared to control, capsaicin-induced Ca2+ influx was smaller in isolated Ins2+/Akita DRG neurons, indicating impaired TRPV1 function.	Capsaicin	123-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	222-227
30811405-6	2019	Genetically modified mice (Sp4+/-) with a 50% reduction of Sp4 showed a reduction in DRG TRPV1 mRNA and neuronal responses to the TRPV1 agonist-capsaicin.	Capsaicin	144-153	trans-acting transcription factor 4	Mus musculus	27-30
30811405-6	2019	Genetically modified mice (Sp4+/-) with a 50% reduction of Sp4 showed a reduction in DRG TRPV1 mRNA and neuronal responses to the TRPV1 agonist-capsaicin.	Capsaicin	144-153	trans-acting transcription factor 4	Mus musculus	59-62
30811405-6	2019	Genetically modified mice (Sp4+/-) with a 50% reduction of Sp4 showed a reduction in DRG TRPV1 mRNA and neuronal responses to the TRPV1 agonist-capsaicin.	Capsaicin	144-153	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	130-135
30809460-6	2019	Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-54
30795543-9	2019	We propose that in poorly controlled diabetes, the accelerated rate of capsaicin-sensitive TRPV1 current decay in DRG neurons decreases overall TRPV1 activity and contributes to peripheral neuropathy.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	91-96
30809460-6	2019	Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release.	Capsaicin	36-45	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	103-107
30809460-6	2019	Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release.	Capsaicin	36-45	neurotrophic receptor tyrosine kinase 2	Rattus norvegicus	130-134
30809460-6	2019	Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release.	Capsaicin	36-45	brain-derived neurotrophic factor	Rattus norvegicus	148-152
30809460-6	2019	Interestingly, the effect of AEA or capsaicin (a TRPV1 agonist, also at 200 nM) on pTRK was blocked by TRKB.Fc (a soluble form of TRKB able to bind BDNF) or capsazepine, suggesting a mechanism dependent on BDNF release.	Capsaicin	36-45	brain-derived neurotrophic factor	Rattus norvegicus	206-210
30795543-9	2019	We propose that in poorly controlled diabetes, the accelerated rate of capsaicin-sensitive TRPV1 current decay in DRG neurons decreases overall TRPV1 activity and contributes to peripheral neuropathy.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	144-149
30838176-0	2019	Capsaicin Induces Apoptosis in KSHV-Positive Primary Effusion Lymphoma by Suppressing ERK and p38 MAPK Signaling and IL-6 Expression.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	86-89
30576973-1	2019	Resiniferatoxin (RTX) is a daphnane diterpene isolated from the latex of Euphorbia resinifera O. Berg, a potent activator of transient receptor potential vanilloid 1 (TrpV1), with a potency 103-105 times greater than pure capsaicin.	Capsaicin	222-231	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	167-172
30838176-0	2019	Capsaicin Induces Apoptosis in KSHV-Positive Primary Effusion Lymphoma by Suppressing ERK and p38 MAPK Signaling and IL-6 Expression.	Capsaicin	0-9	mitogen-activated protein kinase 14	Homo sapiens	94-97
30838176-0	2019	Capsaicin Induces Apoptosis in KSHV-Positive Primary Effusion Lymphoma by Suppressing ERK and p38 MAPK Signaling and IL-6 Expression.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	98-102
30838176-0	2019	Capsaicin Induces Apoptosis in KSHV-Positive Primary Effusion Lymphoma by Suppressing ERK and p38 MAPK Signaling and IL-6 Expression.	Capsaicin	0-9	interleukin 6	Homo sapiens	117-121
30838176-5	2019	Here, we demonstrate that capsaicin markedly inhibited the growth of KSHV latently infected PEL cells by inhibiting ERK, p38 MAPK and expression hIL-6, which are known to contribute to PEL growth and survival.	Capsaicin	26-35	mitogen-activated protein kinase 1	Homo sapiens	116-119
30838176-5	2019	Here, we demonstrate that capsaicin markedly inhibited the growth of KSHV latently infected PEL cells by inhibiting ERK, p38 MAPK and expression hIL-6, which are known to contribute to PEL growth and survival.	Capsaicin	26-35	mitogen-activated protein kinase 14	Homo sapiens	121-124
30838176-5	2019	Here, we demonstrate that capsaicin markedly inhibited the growth of KSHV latently infected PEL cells by inhibiting ERK, p38 MAPK and expression hIL-6, which are known to contribute to PEL growth and survival.	Capsaicin	26-35	interleukin 6	Homo sapiens	145-150
30838176-6	2019	The underlying mechanism of action by capsaicin was through the inhibition of ERK and p38 MAPK phosphorylation and signaling that affected hIL-6 expression.	Capsaicin	38-47	mitogen-activated protein kinase 1	Homo sapiens	78-81
30838176-6	2019	The underlying mechanism of action by capsaicin was through the inhibition of ERK and p38 MAPK phosphorylation and signaling that affected hIL-6 expression.	Capsaicin	38-47	mitogen-activated protein kinase 14	Homo sapiens	86-89
30838176-6	2019	The underlying mechanism of action by capsaicin was through the inhibition of ERK and p38 MAPK phosphorylation and signaling that affected hIL-6 expression.	Capsaicin	38-47	mitogen-activated protein kinase 1	Homo sapiens	90-94
30838176-6	2019	The underlying mechanism of action by capsaicin was through the inhibition of ERK and p38 MAPK phosphorylation and signaling that affected hIL-6 expression.	Capsaicin	38-47	interleukin 6	Homo sapiens	139-144
30838176-7	2019	As a result, capsaicin induced apoptosis in PEL cells in a caspase-9 dependent manner.	Capsaicin	13-22	caspase 9	Homo sapiens	59-68
30496795-2	2019	Here, we show that TRPV1 activation by capsaicin significantly prevents high fat diet-induced obesity in mice.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
30754651-6	2019	On MC3T3-E1 cells and bone marrow-derived osteoblasts, ZOL-evoked current (5 x 10-8 to 10-4 M) was reduced by capsazepine, whereas the selective TRPV1-channel agonist capsaicin potentiated the control current.	Capsaicin	167-176	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	145-150
30717786-9	2019	Cough sensitivity to capsaicin in bleomycin-treated animals was significantly increased on days 13 and 27. qPCR showed that expression of TRPV1 and TRPA1 was positively correlated each other and significantly upregulated in lung tissues of model group compared with that of controls, which was further supported by immunohistochemistry.	Capsaicin	21-30	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	138-143
30717786-9	2019	Cough sensitivity to capsaicin in bleomycin-treated animals was significantly increased on days 13 and 27. qPCR showed that expression of TRPV1 and TRPA1 was positively correlated each other and significantly upregulated in lung tissues of model group compared with that of controls, which was further supported by immunohistochemistry.	Capsaicin	21-30	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	148-153
30278281-3	2019	In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 3b displayed potent antagonism activated by capsaicin (IC50 = 0.084 muM) and protons (IC50 = 0.313 muM).	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
30278281-3	2019	In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 3b displayed potent antagonism activated by capsaicin (IC50 = 0.084 muM) and protons (IC50 = 0.313 muM).	Capsaicin	130-139	latexin	Homo sapiens	154-157
30278281-3	2019	In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 3b displayed potent antagonism activated by capsaicin (IC50 = 0.084 muM) and protons (IC50 = 0.313 muM).	Capsaicin	130-139	latexin	Homo sapiens	185-188
30804682-10	2019	Conclusion: These data suggest that PNL induces an upregulation of T-Type Ca2+-currents in capsaicin-responsive DRG-neurons mediated by an increase of a Ni2+-insensitive current component (possibly Cav3.1 or Cav3.3).	Capsaicin	91-100	calcium channel, voltage-dependent, alpha 1I subunit	Mus musculus	208-214
30496795-8	2019	More interestingly, Trog or capsaicin treatment caused the deacetylation of PPARgamma in 3T3-L1 cells and inhibition of TRPV1 or Sirtuin 1 - prevented this.	Capsaicin	28-37	peroxisome proliferator activated receptor gamma	Mus musculus	76-85
30602263-5	2019	This indicates that vanilloid activators turn on the TRPV1 ion channel to transmit only pain and other nociceptive signals, while capsaicin and its competitive ligands are capable of activating intracellular G protein/PI3K/PIP2 signaling pathways by binding to endogenous cannabinoid receptors, and then increase intracellular PIP2 levels (the increasing PIP2 can competitively replace capsaicin and other vanilloid activators), thereby closing the TRPV1 channel and exerting the analgesic effect.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	449-454
30602263-2	2019	Capsaicin was used as a TRPV1 noxious ion channel activator to investigate the antagonism kinetics of six different substances on capsaicin.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
30602263-5	2019	This indicates that vanilloid activators turn on the TRPV1 ion channel to transmit only pain and other nociceptive signals, while capsaicin and its competitive ligands are capable of activating intracellular G protein/PI3K/PIP2 signaling pathways by binding to endogenous cannabinoid receptors, and then increase intracellular PIP2 levels (the increasing PIP2 can competitively replace capsaicin and other vanilloid activators), thereby closing the TRPV1 channel and exerting the analgesic effect.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	53-58
30294815-2	2019	We hypothesized that regardless of environmental temperature, capsaicin application would stimulate heat loss and concomitantly deactivate heat conservation mechanisms, thus resulting in rectal temperature (Tre) and mean blood pressure decline due to excitation of heat-sensitive TRPV1.	Capsaicin	62-71	transient receptor potential cation channel subfamily V member 1	Homo sapiens	280-285
30094501-8	2019	The molecular docking study on the binding site of transient receptor potential vanilloid subtype 1 (TRPV1) has indicated that like capsaicin, eugenyloxy propanol azole analogues exhibited the strong affinity to bind at site of TPRV1 in a "tail-up, head-down" conformation and the presence of triazolyl moieties has played undeniable role in durable binding of these ligands to TRPV1.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-99
30094501-8	2019	The molecular docking study on the binding site of transient receptor potential vanilloid subtype 1 (TRPV1) has indicated that like capsaicin, eugenyloxy propanol azole analogues exhibited the strong affinity to bind at site of TPRV1 in a "tail-up, head-down" conformation and the presence of triazolyl moieties has played undeniable role in durable binding of these ligands to TRPV1.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-106
30094501-8	2019	The molecular docking study on the binding site of transient receptor potential vanilloid subtype 1 (TRPV1) has indicated that like capsaicin, eugenyloxy propanol azole analogues exhibited the strong affinity to bind at site of TPRV1 in a "tail-up, head-down" conformation and the presence of triazolyl moieties has played undeniable role in durable binding of these ligands to TRPV1.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	378-383
30761069-5	2019	Results: In in vitro experiments, TRPV1 stimulation by capsaicin significantly reduced TNF and IL-6 release by activated microglial cells.	Capsaicin	55-64	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
30761069-5	2019	Results: In in vitro experiments, TRPV1 stimulation by capsaicin significantly reduced TNF and IL-6 release by activated microglial cells.	Capsaicin	55-64	tumor necrosis factor	Homo sapiens	87-90
30761069-5	2019	Results: In in vitro experiments, TRPV1 stimulation by capsaicin significantly reduced TNF and IL-6 release by activated microglial cells.	Capsaicin	55-64	interleukin 6	Homo sapiens	95-99
30587409-4	2019	Here, the role of vlPAG OX1Rs and their interaction with cannabinoid 1 (CB1) receptor was evaluated in anxiety-like behavior following capsaicin-induced dental pulp pain.	Capsaicin	135-144	cannabinoid receptor 1	Rattus norvegicus	72-75
30587409-9	2019	Pretreatment with orexin-A (0.51 mug/rat) attenuated capsaicin-mediated nociception, while exaggerated anxiogenic responses (p &lt; 0.05).	Capsaicin	53-62	hypocretin neuropeptide precursor	Rattus norvegicus	18-26
30587409-11	2019	Intradental capsaicin induced a significant increase in c-fos expression in the vlPAG that was exaggerated by orexin-A (0.51 mug/rat).	Capsaicin	12-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	56-61
30587409-11	2019	Intradental capsaicin induced a significant increase in c-fos expression in the vlPAG that was exaggerated by orexin-A (0.51 mug/rat).	Capsaicin	12-21	hypocretin neuropeptide precursor	Rattus norvegicus	110-118
30587409-12	2019	Blockage of OX1R and CB1 receptors attenuated the effect of orexin-A on c-fos expression in capsaicin-treated rats.	Capsaicin	92-101	hypocretin receptor 1	Rattus norvegicus	12-16
30587409-12	2019	Blockage of OX1R and CB1 receptors attenuated the effect of orexin-A on c-fos expression in capsaicin-treated rats.	Capsaicin	92-101	cannabinoid receptor 1	Rattus norvegicus	21-24
30587409-12	2019	Blockage of OX1R and CB1 receptors attenuated the effect of orexin-A on c-fos expression in capsaicin-treated rats.	Capsaicin	92-101	hypocretin neuropeptide precursor	Rattus norvegicus	60-68
30587409-12	2019	Blockage of OX1R and CB1 receptors attenuated the effect of orexin-A on c-fos expression in capsaicin-treated rats.	Capsaicin	92-101	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	72-77
30587409-13	2019	In conclusion, the data suggest that manipulation of OX1R and CB1 receptors in the vlPAG alters capsaicin-evoked anxiety like behaviors and c-fos induction in rats.	Capsaicin	96-105	hypocretin receptor 1	Rattus norvegicus	53-57
30587409-13	2019	In conclusion, the data suggest that manipulation of OX1R and CB1 receptors in the vlPAG alters capsaicin-evoked anxiety like behaviors and c-fos induction in rats.	Capsaicin	96-105	cannabinoid receptor 1	Rattus norvegicus	62-65
30695053-0	2019	The red pepper"s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKbeta.	Capsaicin	34-43	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	54-58
30695053-0	2019	The red pepper"s spicy ingredient capsaicin activates AMPK in HepG2 cells through CaMKKbeta.	Capsaicin	34-43	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	82-91
30695053-3	2019	As metabolic dysregulation is one of the hallmarks of cancer cells and the key metabolic sensor in the AMP-activated kinase (AMPK), in this study we explored the ability of capsaicin to modulate AMPK activity.	Capsaicin	173-182	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	195-199
30695053-4	2019	We found that capsaicin activated AMPK in HepG2 cells by increasing AMPK phosphorylation and its downstream target ACC.	Capsaicin	14-23	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	34-38
30695053-4	2019	We found that capsaicin activated AMPK in HepG2 cells by increasing AMPK phosphorylation and its downstream target ACC.	Capsaicin	14-23	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	68-72
30695053-5	2019	Mechanistically, we determined that capsaicin activated AMPK through the calcium/calmodulin-dependent protein kinase kinase beta, CaMKKbeta as either the CaMKK inhibitor STO-609 or CaMKK knock down with siRNA abrogated the activation of AMPK.	Capsaicin	36-45	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	56-60
30695053-5	2019	Mechanistically, we determined that capsaicin activated AMPK through the calcium/calmodulin-dependent protein kinase kinase beta, CaMKKbeta as either the CaMKK inhibitor STO-609 or CaMKK knock down with siRNA abrogated the activation of AMPK.	Capsaicin	36-45	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	130-139
30695053-5	2019	Mechanistically, we determined that capsaicin activated AMPK through the calcium/calmodulin-dependent protein kinase kinase beta, CaMKKbeta as either the CaMKK inhibitor STO-609 or CaMKK knock down with siRNA abrogated the activation of AMPK.	Capsaicin	36-45	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	130-135
30695053-5	2019	Mechanistically, we determined that capsaicin activated AMPK through the calcium/calmodulin-dependent protein kinase kinase beta, CaMKKbeta as either the CaMKK inhibitor STO-609 or CaMKK knock down with siRNA abrogated the activation of AMPK.	Capsaicin	36-45	calcium/calmodulin dependent protein kinase kinase 2	Homo sapiens	154-159
30695053-5	2019	Mechanistically, we determined that capsaicin activated AMPK through the calcium/calmodulin-dependent protein kinase kinase beta, CaMKKbeta as either the CaMKK inhibitor STO-609 or CaMKK knock down with siRNA abrogated the activation of AMPK.	Capsaicin	36-45	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	237-241
30695053-6	2019	Moreover, capsaicin decreased cell viability, inhibited Akt/mTOR pathway and increased reactive oxygen species (ROS) in HepG2 cells.	Capsaicin	10-19	AKT serine/threonine kinase 1	Homo sapiens	56-59
30695053-6	2019	Moreover, capsaicin decreased cell viability, inhibited Akt/mTOR pathway and increased reactive oxygen species (ROS) in HepG2 cells.	Capsaicin	10-19	mechanistic target of rapamycin kinase	Homo sapiens	60-64
30695053-7	2019	AMPK activation was involved in the underpinning mechanism of capsaicin-induced cell death.	Capsaicin	62-71	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	0-4
30761248-7	2019	Furthermore, TRPV1 was activated by capsaicin (EC 50 = 20.32 mum), and this effect was antagonized by AMG9810; TRPV2 was activated by a newly developed cannabinoid compound, O1821, and inhibited by tranilast.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
30761248-7	2019	Furthermore, TRPV1 was activated by capsaicin (EC 50 = 20.32 mum), and this effect was antagonized by AMG9810; TRPV2 was activated by a newly developed cannabinoid compound, O1821, and inhibited by tranilast.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 2	Homo sapiens	111-116
30342015-11	2019	Capsaicin decreased MDA (-45.5-76.1%), ET-1 (-19.6-51.6%), and average gray value (AGV) of eNOS (-10.9-48.8%), and increased SOD activity (+31.7-76.1%), NO (+11.2-36.8%), and AGV of iNOS (+6.8-+93.0%) (all P &lt; 0.05).	Capsaicin	0-9	nitric oxide synthase, inducible	Cavia porcellus	182-186
30644819-3	2019	It was recently discovered that four mutations in TRPV2 are sufficient to render the channel sensitive to the TRPV1-specific vanilloid agonist resiniferatoxin (RTx).	Capsaicin	125-134	transient receptor potential cation channel subfamily V member 2	Homo sapiens	50-55
30644819-3	2019	It was recently discovered that four mutations in TRPV2 are sufficient to render the channel sensitive to the TRPV1-specific vanilloid agonist resiniferatoxin (RTx).	Capsaicin	125-134	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
30644819-4	2019	Here, we show that mutation of six residues in TRPV3 corresponding to the vanilloid site in TRPV1 is sufficient to engineer RTx binding.	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 3	Homo sapiens	47-52
30644819-4	2019	Here, we show that mutation of six residues in TRPV3 corresponding to the vanilloid site in TRPV1 is sufficient to engineer RTx binding.	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-97
30587608-4	2019	MATERIALS AND METHODS: PC-12 cells (1x104 cells) were stimulated with 10.0 ng/ml nerve growth factor (NGF) for 2 h and then with 10.0 ng/ml capsaicin in the presence of different concentrations of adiponectin.	Capsaicin	140-149	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	197-208
30381083-3	2019	RESULTS: Capsaicin, a selective TRPV1 agonist, increased ipsilateral afferent renal nerve activity in WT but not TRPV1-/- mice.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	32-37
30504093-12	2019	TRPA1 and TRPV1 stimulation by AITC and capsaicin, respectively, failed to induce any Ca2+ response in the supporting cells, except in a single Hensen"s cell in which AITC evoked transients with smaller amplitude.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	10-15
30587608-11	2019	RESULTS: Treatment of NGF-stimulated PC-12 cells with adiponectin suppressed SP production, which was induced by capsaicin stimulation.	Capsaicin	113-122	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	54-65
30583465-1	2018	Capsaicin is an agonist of the transient receptor potential vanilloid type 1 (TRPV1) channel, which has been related to the pathophysiology of kidney disease secondary to diabetes.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	31-76
30672380-5	2019	Increased expression of TLR4 and TRPV1 as well as increased density of capsaicin-induced TRPV1 current was observed in L4-S2 dorsal root ganglion neurons of the wild-type colitis mice till two weeks post 2,4,6-trinitrobenzene sulfate treatment.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	89-94
30672380-7	2019	In the wild type but not in the TLR4-deficient dorsal root ganglion neurons, acute administration of the TLR4 agonist lipopolysaccharide increased the capsaicin-evoked TRPV1 current.	Capsaicin	151-160	toll-like receptor 4	Mus musculus	105-109
30672380-7	2019	In the wild type but not in the TLR4-deficient dorsal root ganglion neurons, acute administration of the TLR4 agonist lipopolysaccharide increased the capsaicin-evoked TRPV1 current.	Capsaicin	151-160	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	168-173
30583465-1	2018	Capsaicin is an agonist of the transient receptor potential vanilloid type 1 (TRPV1) channel, which has been related to the pathophysiology of kidney disease secondary to diabetes.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-83
30583465-9	2018	These results show that capsaicin had a diuretic effect in healthy and diabetic rats; additionally, it increased the urinary EGF levels and tended to decrease the urinary NAG-L levels.	Capsaicin	24-33	epidermal growth factor like 1	Rattus norvegicus	125-128
30518154-8	2018	(4) Conclusions: Long-term activation of TRPV1 is imminent for the anti-obesity effect of capsaicin.	Capsaicin	90-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
30544766-0	2018	The Investigation of the Antitumor Agent Toxicity and Capsaicin Effect on the Electron Transport Chain Enzymes, Catalase Activities and Lipid Peroxidation Levels in Lung, Heart and Brain Tissues of Rats.	Capsaicin	54-63	catalase	Rattus norvegicus	112-120
30802217-2	2018	capsaicin selectively stimulates nociceptive neurons and its action is mediated through the transient receptor potential channel vanilloid type 1 (TRPV1) receptor.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-145
30409787-3	2018	Macroscopic currents activated by saturating concentrations of LPA applied to excised membrane patches are larger in magnitude than those activated by saturating concentrations of capsaicin, which causes near-maximal TRPV1 open probability.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	217-222
30409787-4	2018	Here we show that activation of TRPV1 by LPA is associated with a higher single-channel conductance than activation by capsaicin.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
30518154-2	2018	Although capsaicin and its nonpungent analogs are shown to enhance energy expenditure, their efficiency to bind to and activate their receptor-transient receptor potential vanilloid subfamily 1 (TRPV1)-to mediate thermogenic effects remains unclear.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	134-193
30518154-2	2018	Although capsaicin and its nonpungent analogs are shown to enhance energy expenditure, their efficiency to bind to and activate their receptor-transient receptor potential vanilloid subfamily 1 (TRPV1)-to mediate thermogenic effects remains unclear.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	195-200
30518154-5	2018	(3) Results: Capsaicin, but not its nonpungent analogs, efficiently binds to TRPV1, prevents high fat diet-induced weight gain, and upregulates thermogenic protein expression in WAT.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	77-82
30518154-6	2018	Molecular docking studies indicate that capsaicin exhibits the highest binding efficacy to TRPV1 because it has a hydrogen bond that anchors it to TRPV1.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	91-96
30518154-6	2018	Molecular docking studies indicate that capsaicin exhibits the highest binding efficacy to TRPV1 because it has a hydrogen bond that anchors it to TRPV1.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	147-152
30207782-4	2018	Here, we show that the TRPV1 agonist capsaicin (100 nM) and hyperosmotic solution (350 vs. 300 mosM) each caused an increase of bumetanide-inhibitable Rb uptake by intact porcine lenses and Na-K-2Cl cotransporter 1 (NKCC1) phosphorylation in the lens epithelium.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-28
30207782-4	2018	Here, we show that the TRPV1 agonist capsaicin (100 nM) and hyperosmotic solution (350 vs. 300 mosM) each caused an increase of bumetanide-inhibitable Rb uptake by intact porcine lenses and Na-K-2Cl cotransporter 1 (NKCC1) phosphorylation in the lens epithelium.	Capsaicin	37-46	solute carrier family 12 member 2	Homo sapiens	190-214
30207782-4	2018	Here, we show that the TRPV1 agonist capsaicin (100 nM) and hyperosmotic solution (350 vs. 300 mosM) each caused an increase of bumetanide-inhibitable Rb uptake by intact porcine lenses and Na-K-2Cl cotransporter 1 (NKCC1) phosphorylation in the lens epithelium.	Capsaicin	37-46	solute carrier family 12 member 2	Homo sapiens	216-221
29858522-11	2018	CONCLUSIONS: The data suggest that rostral ventromedial medulla orexin-A receptors are involved in pulpal nociceptive modulation and improvement of learning and memory deficits induced by intradental application of capsaicin.	Capsaicin	215-224	hypocretin neuropeptide precursor	Rattus norvegicus	64-72
30802217-2	2018	capsaicin selectively stimulates nociceptive neurons and its action is mediated through the transient receptor potential channel vanilloid type 1 (TRPV1) receptor.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	147-152
32186131-9	2018	CONCLUSION: Loureirin B plus capsaicin could produce double blockage on TRPV1 and modulation on TTX-R sodium channel.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
30272354-0	2018	Capsaicin and sorafenib combination treatment exerts synergistic anti-hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling.	Capsaicin	0-9	epidermal growth factor receptor	Homo sapiens	119-123
30473098-5	2018	RESULTS: Capsaicin-induced chemodenervation of whole-body TRPV1 sensory neurons improved glucose clearance and enhanced glucose-stimulated insulin secretion without alterations in beta-cell proliferation and mass, systemic insulin sensitivity, body composition, and energy expenditure.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	58-63
30473098-6	2018	Similarly, denervation of intrapancreatic TRPV1 afferents by pancreas intraductal injection of capsaicin or surgical removal of the dorsal root ganglia projecting into the pancreas lowered post-absorptive glucose levels and increased insulin release upon glucose stimulation.	Capsaicin	95-104	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
30272354-0	2018	Capsaicin and sorafenib combination treatment exerts synergistic anti-hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	133-136
30272354-0	2018	Capsaicin and sorafenib combination treatment exerts synergistic anti-hepatocellular carcinoma activity by suppressing EGFR and PI3K/Akt/mTOR signaling.	Capsaicin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	137-141
30272354-5	2018	In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation.	Capsaicin	14-23	caspase 3	Mus musculus	126-135
30272354-5	2018	In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation.	Capsaicin	14-23	BCL2-associated X protein	Mus musculus	137-140
30272354-5	2018	In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation.	Capsaicin	14-23	poly (ADP-ribose) polymerase family, member 1	Mus musculus	145-172
30272354-5	2018	In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation.	Capsaicin	14-23	B cell leukemia/lymphoma 2	Mus musculus	197-202
30272354-5	2018	In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation.	Capsaicin	14-23	beclin 1, autophagy related	Mus musculus	261-269
30272354-5	2018	In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation.	Capsaicin	14-23	microtubule-associated protein 1 light chain 3 alpha	Mus musculus	274-283
30272354-5	2018	In LM3 cells, capsaicin and sorafenib combination treatment achieved a markedly stronger induction of apoptosis by increasing caspase-3, Bax and poly(ADP-ribose) polymerase activity and inhibiting Bcl-2, and induction of autophagy by upregulating the levels of beclin-1 and LC3A/B II, enhancing P62 degradation.	Capsaicin	14-23	nucleoporin 62	Mus musculus	295-298
30272354-6	2018	The combination of capsaicin and sorafenib also inhibited cell invasion and metastasis via upregulation of E-cadherin and downregulation of N-cadherin, vimentin, matrix metalloproteinase (MMP)2 and MMP9.	Capsaicin	19-28	cadherin 1	Homo sapiens	107-117
30272354-6	2018	The combination of capsaicin and sorafenib also inhibited cell invasion and metastasis via upregulation of E-cadherin and downregulation of N-cadherin, vimentin, matrix metalloproteinase (MMP)2 and MMP9.	Capsaicin	19-28	cadherin 2	Homo sapiens	140-150
30272354-6	2018	The combination of capsaicin and sorafenib also inhibited cell invasion and metastasis via upregulation of E-cadherin and downregulation of N-cadherin, vimentin, matrix metalloproteinase (MMP)2 and MMP9.	Capsaicin	19-28	vimentin	Homo sapiens	152-160
30272354-6	2018	The combination of capsaicin and sorafenib also inhibited cell invasion and metastasis via upregulation of E-cadherin and downregulation of N-cadherin, vimentin, matrix metalloproteinase (MMP)2 and MMP9.	Capsaicin	19-28	matrix metallopeptidase 2	Homo sapiens	162-193
30272354-6	2018	The combination of capsaicin and sorafenib also inhibited cell invasion and metastasis via upregulation of E-cadherin and downregulation of N-cadherin, vimentin, matrix metalloproteinase (MMP)2 and MMP9.	Capsaicin	19-28	matrix metallopeptidase 9	Homo sapiens	198-202
30244119-0	2018	TRPV1 mediates capsaicin-stimulated metabolic activity but not cell death or inhibition of interleukin-1beta release in human THP-1 monocytes.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
30244119-7	2018	Lower concentrations (&lt;250 muM) of capsaicin, but not other putative TRPV1 agonists, were shown to stimulate cell metabolic activity, whereas at concentrations &gt;250 muM, all agonists decreased metabolic activity.	Capsaicin	38-47	latexin	Homo sapiens	30-33
30244119-8	2018	Capsaicin-stimulated THP-1 metabolic activity was blocked by the TRPV1 antagonist, 5-iodo-resiniferatoxin (5"-IRTX), whereas the decline in resorufin production by THP-1 cells at higher capsaicin concentrations (due to cell death), was not affected by 5"-IRTX.	Capsaicin	0-9	GLI family zinc finger 2	Homo sapiens	21-26
30244119-8	2018	Capsaicin-stimulated THP-1 metabolic activity was blocked by the TRPV1 antagonist, 5-iodo-resiniferatoxin (5"-IRTX), whereas the decline in resorufin production by THP-1 cells at higher capsaicin concentrations (due to cell death), was not affected by 5"-IRTX.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
30244119-8	2018	Capsaicin-stimulated THP-1 metabolic activity was blocked by the TRPV1 antagonist, 5-iodo-resiniferatoxin (5"-IRTX), whereas the decline in resorufin production by THP-1 cells at higher capsaicin concentrations (due to cell death), was not affected by 5"-IRTX.	Capsaicin	186-195	GLI family zinc finger 2	Homo sapiens	164-169
30244119-12	2018	In addition, capsaicin modifies cytokine release from THP-1 cells and induces cell death, most likely by a mechanism that is independent of TRPV1 activation.	Capsaicin	13-22	GLI family zinc finger 2	Homo sapiens	54-59
30244119-9	2018	Finally, capsaicin (&lt;=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin.	Capsaicin	9-18	latexin	Homo sapiens	29-32
30244119-9	2018	Finally, capsaicin (&lt;=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin.	Capsaicin	9-18	interleukin 6	Homo sapiens	88-92
30244119-9	2018	Finally, capsaicin (&lt;=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin.	Capsaicin	9-18	tumor necrosis factor	Homo sapiens	97-106
30244119-9	2018	Finally, capsaicin (&lt;=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin.	Capsaicin	9-18	GLI family zinc finger 2	Homo sapiens	120-125
30244119-9	2018	Finally, capsaicin (&lt;=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin.	Capsaicin	9-18	tumor necrosis factor	Homo sapiens	182-191
30244119-9	2018	Finally, capsaicin (&lt;=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin.	Capsaicin	9-18	C-C motif chemokine ligand 2	Homo sapiens	193-198
30244119-9	2018	Finally, capsaicin (&lt;=125 muM) significantly increased lipopolysaccharide-stimulated IL-6 and TNF-alpha release from THP-1 cells, whereas phytohaemagglutinin-stimulated IL-1beta, TNF-alpha, MCP-1 and IL-6 release were concentration-dependently inhibited by capsaicin.	Capsaicin	9-18	interleukin 6	Homo sapiens	203-207
30483120-2	2018	3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells.	Capsaicin	157-166	transient receptor potential cation channel subfamily M member 8	Homo sapiens	80-96
30956864-3	2019	With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats.	Capsaicin	46-59	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	344-347
30956864-3	2019	With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats.	Capsaicin	46-59	nuclear receptor subfamily 1, group H, member 4	Rattus norvegicus	445-448
30240782-7	2018	Through immunohistochemistry, we showed that the increased knee neuron capsaicin sensitivity correlated with enhanced expression of the capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1) in knee-innervating neurons of the CFA-injected side.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	156-196
30240782-7	2018	Through immunohistochemistry, we showed that the increased knee neuron capsaicin sensitivity correlated with enhanced expression of the capsaicin receptor, transient receptor potential vanilloid 1 (TRPV1) in knee-innervating neurons of the CFA-injected side.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	198-203
30524369-4	2018	The TRPV1 agonist capsaicin increased both intracellular Ca2+ levels and whole-cell currents, while the antagonist capsazepine (CPZ) inhibited them.	Capsaicin	18-27	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
30342853-7	2018	In addition, it was also discovered that the level of phospho-ERK/ERK (p-ERK/ERK) showed an increase in spinal cord and kidney after degeneration of capsaicin sensitive sensory nerves.	Capsaicin	149-158	Eph receptor B1	Rattus norvegicus	62-65
30342853-7	2018	In addition, it was also discovered that the level of phospho-ERK/ERK (p-ERK/ERK) showed an increase in spinal cord and kidney after degeneration of capsaicin sensitive sensory nerves.	Capsaicin	149-158	Eph receptor B1	Rattus norvegicus	66-69
30342853-7	2018	In addition, it was also discovered that the level of phospho-ERK/ERK (p-ERK/ERK) showed an increase in spinal cord and kidney after degeneration of capsaicin sensitive sensory nerves.	Capsaicin	149-158	Eph receptor B1	Rattus norvegicus	66-69
30342853-7	2018	In addition, it was also discovered that the level of phospho-ERK/ERK (p-ERK/ERK) showed an increase in spinal cord and kidney after degeneration of capsaicin sensitive sensory nerves.	Capsaicin	149-158	Eph receptor B1	Rattus norvegicus	66-69
30956864-3	2019	With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats.	Capsaicin	46-59	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	235-266
30956864-3	2019	With certain combinations of sanshoamides and capsaicinoids significantly increased food intake, reduced lipid levels in blood and liver, improved histological characteristics of a fatty liver, down regulated mRNA expression levels of cholesterol 7-alpha-hydroxylase (CYP7A1), 3-hydroxyl-3-methylglutary CoA (HMG-CoA) and Farnesoid X Receptor (FXR) in liver and apical sodium-dependent bile acid transporter, Ileal Bile Acid Binding Protein and FXR in the ileum in hyperlipidemic rats.	Capsaicin	46-59	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	268-274
30266739-4	2018	We report here that MBD1 in the primary sensory neurons of DRG is critical for the genesis of acute pain and neuropathic pain as DRG MBD1-deficient mice exhibit the reduced responses to acute mechanical, heat, cold, and capsaicin stimuli and the blunted nerve injury-induced pain hypersensitivities.	Capsaicin	220-229	methyl-CpG binding domain protein 1	Mus musculus	20-24
30266739-4	2018	We report here that MBD1 in the primary sensory neurons of DRG is critical for the genesis of acute pain and neuropathic pain as DRG MBD1-deficient mice exhibit the reduced responses to acute mechanical, heat, cold, and capsaicin stimuli and the blunted nerve injury-induced pain hypersensitivities.	Capsaicin	220-229	methyl-CpG binding domain protein 1	Mus musculus	133-137
30417826-5	2018	We found that the TrpV1-receptor agonist capsaicin rescues Abeta-induced degradation of hippocampal gamma oscillations by reversing both the desynchronization of AP firing in CA3 pyramidal cells and the shift in excitatory/inhibitory current balance.	Capsaicin	41-50	amyloid beta precursor protein	Homo sapiens	59-64
30483120-2	2018	3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells.	Capsaicin	157-166	transient receptor potential cation channel subfamily M member 8	Homo sapiens	98-103
30483120-2	2018	3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells.	Capsaicin	157-166	transient receptor potential cation channel subfamily V member 1	Homo sapiens	119-134
30483120-2	2018	3-Iodothyronamine (3-T1AM), an endogenous thyroid hormone metabolite, activates TRP melastatin 8 (TRPM8), which blunts TRP vanilloid 1 (TRPV1) activation by capsaicin (CAP) in human corneal, conjunctival epithelial cells, and stromal cells.	Capsaicin	157-166	transient receptor potential cation channel subfamily V member 1	Homo sapiens	136-141
30423807-1	2018	We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-100
30423807-1	2018	We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	102-107
30423807-1	2018	We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat.	Capsaicin	32-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-100
30423807-1	2018	We demonstrated that capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), inhibits microglia activation and microglia-derived oxidative stress in the substantia nigra (SN) of MPP+-lesioned rat.	Capsaicin	32-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	102-107
29326052-3	2018	Our study was aimed to analyse the effect of female sex hormones (oestrogen - E2 and progesterone - Pg) on cough sensitivity measured by inhalation of capsaicin in follicular and luteal phases of menstrual cycle, characterized by significantly different concentrations of sex hormones.	Capsaicin	151-160	cystatin 12, pseudogene	Homo sapiens	78-102
30226565-5	2018	Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV-induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression.	Capsaicin	189-198	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
30015706-4	2018	Studying the effect of complete Freund adjuvant (CFA)-induced inflammation on capsaicin-activated TRPV1 nociceptive responses in dorsal root ganglia (DRG), we found that CFA produced a large increase in capsaicin-induced responses.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
30015706-4	2018	Studying the effect of complete Freund adjuvant (CFA)-induced inflammation on capsaicin-activated TRPV1 nociceptive responses in dorsal root ganglia (DRG), we found that CFA produced a large increase in capsaicin-induced responses.	Capsaicin	203-212	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
30341332-7	2018	However, we show that ablation of TRPV1+ neurons or acute TRPV1 activation by capsaicin abolishes DAMGO-induced itch.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	58-63
30706039-1	2018	Introduction: NEO6860 is a TRPV1 antagonist when activated by capsaicin but not by heat or pH, developed to relieve pain without the adverse events reported with non-modality-selective TRPV1 antagonists.	Capsaicin	62-71	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
30079821-6	2018	RESULTS: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocampus of rats with biliary cirrhosis.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	50-55
30079821-6	2018	RESULTS: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocampus of rats with biliary cirrhosis.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	157-162
30079821-6	2018	RESULTS: Our results indicated that activation of TRPV1 channels by capsaicin significantly decreased memory impairment and increased mRNA expression of the TRPV1 and CREB in the hippocampus of rats with biliary cirrhosis.	Capsaicin	68-77	cAMP responsive element binding protein 1	Rattus norvegicus	167-171
30341332-7	2018	However, we show that ablation of TRPV1+ neurons or acute TRPV1 activation by capsaicin abolishes DAMGO-induced itch.	Capsaicin	78-87	itchy, E3 ubiquitin protein ligase	Mus musculus	112-116
30341332-9	2018	Activation of these fibers by capsaicin prevents the opioid-induced itch.	Capsaicin	30-39	itchy, E3 ubiquitin protein ligase	Mus musculus	68-72
30138635-2	2018	The aim of this study was to evaluate the antidepressant-like properties of the TRPV1 agonist capsaicin using the forced swimming test (FST) in rats.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	80-85
30386208-7	2018	Arguing against obligatory heteromerization, optical imaging showed that activation and desensitization of TRPV1 and TRPV4 responses evoked by capsaicin and GSK1016790A are independent of each other.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
30386208-7	2018	Arguing against obligatory heteromerization, optical imaging showed that activation and desensitization of TRPV1 and TRPV4 responses evoked by capsaicin and GSK1016790A are independent of each other.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	117-122
30374305-3	2018	We previously found that CAP can also be transported via TRPV1, which was site-specific in the permeability of CAP across the intestine.	Capsaicin	25-28	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
30374305-3	2018	We previously found that CAP can also be transported via TRPV1, which was site-specific in the permeability of CAP across the intestine.	Capsaicin	111-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
30374312-7	2018	As TNF-alpha synthesis suppressor pentoxifylline (PTX) was previously administered into the hindlimb with femoral artery occlusion, sympathetic, and pressor responses induced by capsaicin and AITC were attenuated.	Capsaicin	178-187	tumor necrosis factor	Rattus norvegicus	3-12
30930626-6	2018	Besides, when the cells were cultured with capsaicin at their determined IC50 value for 24 h and their caspase-3 gene expression levels were detected by real-time polymerase chain reaction (RTPCR) and western blotting, it was demonstrated that the caspase-3 protein and mRNA levels were not altered in any cells upon capsaicin exposure, suggesting a caspase-independent pathway for cell death.	Capsaicin	43-52	caspase 3	Homo sapiens	103-112
30930626-6	2018	Besides, when the cells were cultured with capsaicin at their determined IC50 value for 24 h and their caspase-3 gene expression levels were detected by real-time polymerase chain reaction (RTPCR) and western blotting, it was demonstrated that the caspase-3 protein and mRNA levels were not altered in any cells upon capsaicin exposure, suggesting a caspase-independent pathway for cell death.	Capsaicin	43-52	caspase 3	Homo sapiens	248-257
30930626-6	2018	Besides, when the cells were cultured with capsaicin at their determined IC50 value for 24 h and their caspase-3 gene expression levels were detected by real-time polymerase chain reaction (RTPCR) and western blotting, it was demonstrated that the caspase-3 protein and mRNA levels were not altered in any cells upon capsaicin exposure, suggesting a caspase-independent pathway for cell death.	Capsaicin	317-326	caspase 3	Homo sapiens	103-112
30930626-6	2018	Besides, when the cells were cultured with capsaicin at their determined IC50 value for 24 h and their caspase-3 gene expression levels were detected by real-time polymerase chain reaction (RTPCR) and western blotting, it was demonstrated that the caspase-3 protein and mRNA levels were not altered in any cells upon capsaicin exposure, suggesting a caspase-independent pathway for cell death.	Capsaicin	317-326	caspase 3	Homo sapiens	248-257
30323679-0	2018	Capsaicin-induced TRIB3 upregulation promotes apoptosis in cancer cells.	Capsaicin	0-9	tribbles pseudokinase 3	Homo sapiens	18-23
30305457-9	2018	Punctate and dynamic allodynia in response to capsaicin-induced inflammation and spared nerve injury was absent in Piezo2-deficient mice.	Capsaicin	46-55	piezo-type mechanosensitive ion channel component 2	Mus musculus	115-121
30139740-7	2018	We further show that the Wnt/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.	Capsaicin	119-128	catenin beta 1	Homo sapiens	29-41
30139740-7	2018	We further show that the Wnt/beta-catenin/BDNF axis in the spinal neural circuit plays an important role in regulating capsaicin-induced pain.	Capsaicin	119-128	brain derived neurotrophic factor	Homo sapiens	42-46
30323679-5	2018	Purpose: The aim of this study was to examine the importance of TRIB3 in the antitumor efficacy of capsaicin in human cancer cells, and further assess potential mechanism(s) underlying the capsaicin-induced upregulation of TRIB3.	Capsaicin	99-108	tribbles pseudokinase 3	Homo sapiens	64-69
30323679-5	2018	Purpose: The aim of this study was to examine the importance of TRIB3 in the antitumor efficacy of capsaicin in human cancer cells, and further assess potential mechanism(s) underlying the capsaicin-induced upregulation of TRIB3.	Capsaicin	189-198	tribbles pseudokinase 3	Homo sapiens	223-228
30323679-7	2018	The impact of TRIB3 on capsaicin-induced apoptosis was investigated using si-RNA or overexpression of TRIB3.	Capsaicin	23-32	tribbles pseudokinase 3	Homo sapiens	14-19
30323679-8	2018	Results: It is the first time to show that TRIB3 is targeted by capsaicin to promote apoptosis.	Capsaicin	64-73	tribbles pseudokinase 3	Homo sapiens	43-48
29672123-8	2018	Not only did IFN-gamma enhance the response of neurons to capsaicin and electric stimulation, but also it directly induced Ca2+ influx, membrane depolarization, and action potentials in neurons via the Janus kinase, protein kinase A, and alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid pathways.	Capsaicin	58-67	interferon gamma	Rattus norvegicus	13-22
30323679-9	2018	Capsaicin promotes apoptotic cell death by upregulating TRIB3 expression in cancer cells.	Capsaicin	0-9	tribbles pseudokinase 3	Homo sapiens	56-61
30323679-10	2018	Overexpression of TRIB3 enhances capsaicin-induced apoptosis, and TRIB3 knockdown experiments demonstrate that the effect of capsaicin in apoptotic cell death is correlated with the induction of TRIB3 in cancer cells.	Capsaicin	33-42	tribbles pseudokinase 3	Homo sapiens	18-23
30323679-10	2018	Overexpression of TRIB3 enhances capsaicin-induced apoptosis, and TRIB3 knockdown experiments demonstrate that the effect of capsaicin in apoptotic cell death is correlated with the induction of TRIB3 in cancer cells.	Capsaicin	125-134	tribbles pseudokinase 3	Homo sapiens	18-23
30323679-10	2018	Overexpression of TRIB3 enhances capsaicin-induced apoptosis, and TRIB3 knockdown experiments demonstrate that the effect of capsaicin in apoptotic cell death is correlated with the induction of TRIB3 in cancer cells.	Capsaicin	125-134	tribbles pseudokinase 3	Homo sapiens	66-71
30323679-10	2018	Overexpression of TRIB3 enhances capsaicin-induced apoptosis, and TRIB3 knockdown experiments demonstrate that the effect of capsaicin in apoptotic cell death is correlated with the induction of TRIB3 in cancer cells.	Capsaicin	125-134	tribbles pseudokinase 3	Homo sapiens	66-71
30323679-11	2018	Finally, enhancements in gene expression and protein stability are involved in the capsaicin-induced upregulation of TRIB3.	Capsaicin	83-92	tribbles pseudokinase 3	Homo sapiens	117-122
30323679-12	2018	Conclusion: Our results show that the capsaicin-induced upregulation of TRIB3 triggers apoptosis and thereby contributes to the suppression of cell growth in cancer cell lines.	Capsaicin	38-47	tribbles pseudokinase 3	Homo sapiens	72-77
29797679-5	2018	Furthermore, exposure of cultured human DRG neurons to PTHrP leads to slow-sustained activation of TRPV1 and modulation of capsaicin-induced channel activation.	Capsaicin	123-132	parathyroid hormone like hormone	Homo sapiens	55-60
29580868-6	2018	We then proved that TRPV1 overexpression or its agonist capsaicin treatment inhibited melanoma growth by activating p53 and inducing cell apoptosis.	Capsaicin	56-65	tumor protein p53	Homo sapiens	116-119
30014177-1	2018	The TRPV1 channel is activated in neurons by capsaicin, oxidative stress, acidic pH and heat factors, and these factors are attenuated by the antioxidant role of calorie restriction (CR).	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
30100034-7	2018	RESULTS: Capsaicin pretreatment reduced wet-to-dry ratio, pathologic score, alveolar-arterial oxygen gradient (A-aDO2), and IL1beta, IL6, and TNFalpha levels in WT mice, with no effects in KO mice.	Capsaicin	9-18	interleukin 1 beta	Mus musculus	124-131
30100034-7	2018	RESULTS: Capsaicin pretreatment reduced wet-to-dry ratio, pathologic score, alveolar-arterial oxygen gradient (A-aDO2), and IL1beta, IL6, and TNFalpha levels in WT mice, with no effects in KO mice.	Capsaicin	9-18	interleukin 6	Mus musculus	133-136
30100034-7	2018	RESULTS: Capsaicin pretreatment reduced wet-to-dry ratio, pathologic score, alveolar-arterial oxygen gradient (A-aDO2), and IL1beta, IL6, and TNFalpha levels in WT mice, with no effects in KO mice.	Capsaicin	9-18	tumor necrosis factor	Mus musculus	142-150
30100034-10	2018	Capsaicin also decreased cleaved caspase-3, caspase-3/9, and Bax protein expression, effects abolished by TRPV1 blockade.	Capsaicin	0-9	caspase 3	Mus musculus	44-55
30100034-10	2018	Capsaicin also decreased cleaved caspase-3, caspase-3/9, and Bax protein expression, effects abolished by TRPV1 blockade.	Capsaicin	0-9	BCL2-associated X protein	Mus musculus	61-64
30100034-10	2018	Capsaicin also decreased cleaved caspase-3, caspase-3/9, and Bax protein expression, effects abolished by TRPV1 blockade.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	106-111
30100034-11	2018	Similarly, alpha7nAChR blockade diminished capsaicin-induced downregulation of apoptotic proteins, and alpha7nAChR activation decreased expression levels even under TRPV1 blockade.	Capsaicin	43-52	cholinergic receptor, nicotinic, alpha polypeptide 7	Mus musculus	11-22
30274279-6	2018	The capacity of DPV576 to modulate the activity of TRPV1 agonist capsaicin in CD4+ T cells was also determined.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
29847470-4	2018	This human experimental study investigated whether functional responses from the subpopulation of TRPA1 nociceptors could be evoked after defunctionalization of TRPV1 nociceptors by cutaneous application of high-concentration capsaicin.	Capsaicin	226-235	transient receptor potential cation channel subfamily A member 1	Homo sapiens	98-103
29847470-4	2018	This human experimental study investigated whether functional responses from the subpopulation of TRPA1 nociceptors could be evoked after defunctionalization of TRPV1 nociceptors by cutaneous application of high-concentration capsaicin.	Capsaicin	226-235	transient receptor potential cation channel subfamily V member 1	Homo sapiens	161-166
29847470-12	2018	Ablation of cutaneous capsaicin-sensitive afferents caused consistent and equal inhibition of both TRPV1- and TRPA1-provoked responses assessed psychophysically and by imaging of vasomotor responses.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	99-104
29847470-12	2018	Ablation of cutaneous capsaicin-sensitive afferents caused consistent and equal inhibition of both TRPV1- and TRPA1-provoked responses assessed psychophysically and by imaging of vasomotor responses.	Capsaicin	22-31	transient receptor potential cation channel subfamily A member 1	Homo sapiens	110-115
29847470-13	2018	This study suggests that TRPA1 nociceptive responses in human skin strongly depend on intact capsaicin-sensitive, TRPV1 fibers.	Capsaicin	93-102	transient receptor potential cation channel subfamily A member 1	Homo sapiens	25-30
29847470-13	2018	This study suggests that TRPA1 nociceptive responses in human skin strongly depend on intact capsaicin-sensitive, TRPV1 fibers.	Capsaicin	93-102	transient receptor potential cation channel subfamily V member 1	Homo sapiens	114-119
30274279-6	2018	The capacity of DPV576 to modulate the activity of TRPV1 agonist capsaicin in CD4+ T cells was also determined.	Capsaicin	65-74	CD4 molecule	Homo sapiens	78-81
30274279-9	2018	This was accompanied by decreased secretion of IFN-gamma and reduced expression of TRPV1 in capsaicin activated CD4+ T cells.	Capsaicin	92-101	transient receptor potential cation channel subfamily V member 1	Homo sapiens	83-88
30274279-9	2018	This was accompanied by decreased secretion of IFN-gamma and reduced expression of TRPV1 in capsaicin activated CD4+ T cells.	Capsaicin	92-101	CD4 molecule	Homo sapiens	112-115
30176215-2	2018	Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure-activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain fatty acid ethanolamides or primary amides acting as TRPV2 antagonists.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 2	Homo sapiens	93-98
30274172-14	2018	In capsaicin-denervated rats, CORM-2 increased eNOS mRNA fold change and TRPV1 protein expression while capsaicin denervation itself decreased HMOX-1 protein expression and eNOS mRNA level.	Capsaicin	104-113	heme oxygenase 1	Rattus norvegicus	143-149
30176215-2	2018	Here we describe the discovery of novel synthetic long-chain capsaicin derivatives as potent TRPV2 antagonists in comparison to the totally inactive capsaicin, the role of their hydrophobic chain, and how the structure-activity relationships of such derivatives led, through a ligand-based approach, to the identification of endogenous long-chain fatty acid ethanolamides or primary amides acting as TRPV2 antagonists.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 2	Homo sapiens	400-405
30534627-9	2018	Granulocyte-macrophage colony-stimulating factor treatment sensitized capsaicin responses in vitro, which were diminished by p38 MAPK or TrkA inhibitors.	Capsaicin	70-79	neurotrophic receptor tyrosine kinase 1	Homo sapiens	137-141
30319425-11	2018	Peripherally, TPM significantly inhibited capsaicin-induced CGRP expression of TG in adult, but not pediatric, rats.	Capsaicin	42-51	calcitonin-related polypeptide alpha	Rattus norvegicus	60-64
30319425-12	2018	Interestingly, the capsaicin-induced depletion of CGRP in dura was significantly rescued by TPM at high doses in adults, but at low dose in pediatric group.	Capsaicin	19-28	calcitonin-related polypeptide alpha	Rattus norvegicus	50-54
30534627-9	2018	Granulocyte-macrophage colony-stimulating factor treatment sensitized capsaicin responses in vitro, which were diminished by p38 MAPK or TrkA inhibitors.	Capsaicin	70-79	colony stimulating factor 2	Homo sapiens	0-48
30260982-10	2018	When neurites of NGF cultured somata were grown in GDNF, capsaicin evoked a lower CGRP release than high potassium, compared to those grown in NGF.	Capsaicin	57-66	nerve growth factor	Mus musculus	17-20
30260982-10	2018	When neurites of NGF cultured somata were grown in GDNF, capsaicin evoked a lower CGRP release than high potassium, compared to those grown in NGF.	Capsaicin	57-66	glial cell line derived neurotrophic factor	Mus musculus	51-55
30260982-10	2018	When neurites of NGF cultured somata were grown in GDNF, capsaicin evoked a lower CGRP release than high potassium, compared to those grown in NGF.	Capsaicin	57-66	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	82-86
30250009-6	2018	The P25 (p &lt; 0.001) SEP peak significantly decreased following capsaicin application for all groups.	Capsaicin	66-75	tubulin polymerization promoting protein	Homo sapiens	4-7
30183290-3	2018	Hesperidin and capsaicin separately, but not (or to a lesser extent) the combination, resulted in a decreased size of adipocytes and induced emergence of multilocular brown-like adipocytes positive for UCP1 and CIDEA in retroperitoneal WAT.	Capsaicin	15-24	uncoupling protein 1	Rattus norvegicus	202-206
30183290-3	2018	Hesperidin and capsaicin separately, but not (or to a lesser extent) the combination, resulted in a decreased size of adipocytes and induced emergence of multilocular brown-like adipocytes positive for UCP1 and CIDEA in retroperitoneal WAT.	Capsaicin	15-24	cell death-inducing DFFA-like effector a	Rattus norvegicus	211-216
30183290-4	2018	Expression levels of browning markers, such as Prdm16, in inguinal WAT also increased with capsaicin treatment compared with the vehicle (145% +- 17% vs 92% +- 21%, P &lt; 0.05), but no significant effects were found with the combination (106% +- 12%).	Capsaicin	91-100	PR/SET domain 16	Rattus norvegicus	47-53
30016665-13	2018	significantly attenuated the TCC neuronal activation and TG CGRP-ir elevation, and dural CGRP depletion induced by capsaicin.	Capsaicin	115-124	calcitonin-related polypeptide alpha	Rattus norvegicus	89-93
30534627-9	2018	Granulocyte-macrophage colony-stimulating factor treatment sensitized capsaicin responses in vitro, which were diminished by p38 MAPK or TrkA inhibitors.	Capsaicin	70-79	mitogen-activated protein kinase 14	Homo sapiens	125-128
30067911-8	2018	One of the five anesthetic binding sites reported was previously identified experimentally, and another one, importantly, is identical to that of capsaicin, one of the chemical stimuli that activate TRPV1.	Capsaicin	146-155	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
30009814-9	2018	PAC was able to inhibit capsaicin-induced nociception, showing involvement of TRPV1.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
30122375-4	2018	Capsaicin-activated nociceptor inputs reduce IA and sensitize the T neurons, allowing Abeta inputs to cause firing before inhibitory inputs arrive.	Capsaicin	0-9	amyloid beta precursor protein	Homo sapiens	86-91
30181391-0	2018	Editor"s Note: Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6-Inducible STAT3 Activation.	Capsaicin	15-24	interleukin 6	Homo sapiens	64-77
30365624-6	2018	However, an increased expression of COX-2 and decreased expression of BDNF was observed in the hippocampus of animals that received capsaicin or SB-334867-A (80 nM) plus capsaicin.	Capsaicin	132-141	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	36-41
30365624-6	2018	However, an increased expression of COX-2 and decreased expression of BDNF was observed in the hippocampus of animals that received capsaicin or SB-334867-A (80 nM) plus capsaicin.	Capsaicin	132-141	brain-derived neurotrophic factor	Rattus norvegicus	70-74
30365624-6	2018	However, an increased expression of COX-2 and decreased expression of BDNF was observed in the hippocampus of animals that received capsaicin or SB-334867-A (80 nM) plus capsaicin.	Capsaicin	170-179	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	36-41
30365624-6	2018	However, an increased expression of COX-2 and decreased expression of BDNF was observed in the hippocampus of animals that received capsaicin or SB-334867-A (80 nM) plus capsaicin.	Capsaicin	170-179	brain-derived neurotrophic factor	Rattus norvegicus	70-74
30365624-7	2018	Meanwhile, orexin-A (40 pM) attenuated the effects of capsaicin on the expression of COX-2 and BDNF.	Capsaicin	54-63	hypocretin neuropeptide precursor	Rattus norvegicus	11-19
30365624-7	2018	Meanwhile, orexin-A (40 pM) attenuated the effects of capsaicin on the expression of COX-2 and BDNF.	Capsaicin	54-63	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	85-90
30365624-7	2018	Meanwhile, orexin-A (40 pM) attenuated the effects of capsaicin on the expression of COX-2 and BDNF.	Capsaicin	54-63	brain-derived neurotrophic factor	Rattus norvegicus	95-99
30365624-8	2018	CONCLUSIONS: CA1 OX1R activation moderates capsaicin-induced neuronal inflammation and neurotrophic deficiency.	Capsaicin	43-52	carbonic anhydrase 1	Rattus norvegicus	13-16
30365624-8	2018	CONCLUSIONS: CA1 OX1R activation moderates capsaicin-induced neuronal inflammation and neurotrophic deficiency.	Capsaicin	43-52	hypocretin receptor 1	Rattus norvegicus	17-21
30251173-1	2018	The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	140-180
30251173-1	2018	The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	182-188
30251173-1	2018	The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain.	Capsaicin	99-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	140-180
30251173-1	2018	The adhesive capsaicin dermal patch (Qutenza ) delivers a high concentration (8% w/w) of synthetic capsaicin, a highly selective agonist of transient receptor potential vanilloid-1 (TRPV-1), directly to the site of pain.	Capsaicin	99-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	182-188
29959973-8	2018	In addition, GLP-1R knockdown elevated downstream TRPV1 expression and promoted capsaicin-induced TRPV1 function, which may regulate inhibitory neurotransmission to affect seizure susceptibility.	Capsaicin	80-89	glucagon-like peptide 1 receptor	Rattus norvegicus	13-19
29959973-8	2018	In addition, GLP-1R knockdown elevated downstream TRPV1 expression and promoted capsaicin-induced TRPV1 function, which may regulate inhibitory neurotransmission to affect seizure susceptibility.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
30181391-0	2018	Editor"s Note: Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6-Inducible STAT3 Activation.	Capsaicin	15-24	signal transducer and activator of transcription 3	Homo sapiens	88-93
30078610-2	2018	The analysis of the structure-activity relationship indicated that 2-(3,5-dihalo 4-aminophenyl)acetamide analogues displayed excellent antagonism of hTRPV1 activation by capsaicin and showed improved potency compared to the corresponding propanamides.	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-155
29664171-1	2018	Capsaicin reduced poly(lactic-co-glycolic) acid (PLGA)-induced fibrosis by promoting IL-10 secretion and suppressing alpha-smooth muscle actin (alpha-SMA) expression.	Capsaicin	0-9	interleukin 10	Mus musculus	85-90
29664171-1	2018	Capsaicin reduced poly(lactic-co-glycolic) acid (PLGA)-induced fibrosis by promoting IL-10 secretion and suppressing alpha-smooth muscle actin (alpha-SMA) expression.	Capsaicin	0-9	actin alpha 2, smooth muscle, aorta	Mus musculus	117-142
29664171-1	2018	Capsaicin reduced poly(lactic-co-glycolic) acid (PLGA)-induced fibrosis by promoting IL-10 secretion and suppressing alpha-smooth muscle actin (alpha-SMA) expression.	Capsaicin	0-9	actin alpha 2, smooth muscle, aorta	Mus musculus	144-153
29664171-4	2018	RAW 264.7 cells cultured on PLGA films with capsaicin responded with significant (p &lt; 0.05) upregulation in M2 markers arginase-1 and IL-10 and downregulation of M1 markers iNOS and IL-12, demonstrating the potential of capsaicin to reduce PLGA-induced inflammation.	Capsaicin	44-53	arginase, liver	Mus musculus	122-132
29664171-4	2018	RAW 264.7 cells cultured on PLGA films with capsaicin responded with significant (p &lt; 0.05) upregulation in M2 markers arginase-1 and IL-10 and downregulation of M1 markers iNOS and IL-12, demonstrating the potential of capsaicin to reduce PLGA-induced inflammation.	Capsaicin	44-53	interleukin 10	Mus musculus	137-142
29664171-7	2018	Capsaicin caused a 35% increase in IL-10 which played a key role in suppressing fibrosis.	Capsaicin	0-9	interleukin 10	Mus musculus	35-40
29664171-8	2018	Macrophage phenotype markers in peritoneal cells and adherent cells were unaffected by capsaicin; however, capsaicin suppressed the myofibroblast marker alpha-SMA in adherent cells by day 14.	Capsaicin	107-116	actin alpha 2, smooth muscle, aorta	Mus musculus	153-162
29427475-0	2018	Application of an 8% capsaicin patch normalizes epidermal TRPV1 expression but not the decreased intraepidermal nerve fibre density in patients with brachioradial pruritus.	Capsaicin	21-30	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
29427475-9	2018	CONCLUSION: The normalization of the decreased TRPV1 expression may account for the effectiveness of topical capsaicin, which does not reconstitute the reduced IENFD, arguing for a role of epidermal TRPV1 in the maintenance of BRP.	Capsaicin	109-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
30173779-4	2018	This study used resiniferatoxin (RTX), an ultrapotent analog of capsaicin, to generate a mouse model of SFN, leading to marked hindpaw edema (p = 0.013) and parallel the release of TNFalpha (p = 0.014), which was associated with the upregulation of Ret(+) neurons (p = 0.0043) and partial depletion of TNFR1 caused by colocalization with TRPV1 depleted by RTX.	Capsaicin	64-73	RNA exonuclease 2	Mus musculus	104-107
30347923-3	2018	Rats were given capsaicin (50 mg kg-1) by subcutaneous injections 1 days before and 7, 14, 21 days after induce pulmonary fibrosis rat model to deplete endogenous CGRP.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	163-167
30142945-0	2018	Multi-Spectroscopic and Theoretical Analysis on the Interaction between Human Serum Albumin and a Capsaicin Derivative-RPF101.	Capsaicin	98-107	albumin	Homo sapiens	78-91
30142945-1	2018	The interaction between the main carrier of endogenous and exogenous compounds in the human bloodstream (human serum albumin, HSA) and a potential anticancer compound (the capsaicin analogue RPF101) was investigated by spectroscopic techniques (circular dichroism, steady-state, time-resolved, and synchronous fluorescence), zeta potential, and computational method (molecular docking).	Capsaicin	172-181	albumin	Homo sapiens	111-124
30078610-3	2018	The most potent antagonist (36) exhibited potent and selective antagonism for hTRPV1 not only to capsaicin but also to NADA and elevated temperature; however, it only displayed weak antagonism to low pH.	Capsaicin	97-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	78-84
29884534-2	2018	The analysis of structure-activity relationship indicated that a fluoro group at the 3- (or/and) 5-position and a methylsulfonamido group at the 4-position were optimal for antagonism of TRPV1 activation by capsaicin.	Capsaicin	207-216	transient receptor potential cation channel subfamily V member 1	Homo sapiens	187-192
29884534-3	2018	The most potent antagonist 6 not only exhibited potent antagonism of activation of hTRPV1 by capsaicin, low pH and elevated temperature but also displayed highly potent antagonism of activation of rTRPV1 by capsaicin.	Capsaicin	93-102	transient receptor potential cation channel subfamily V member 1	Homo sapiens	83-89
29884534-3	2018	The most potent antagonist 6 not only exhibited potent antagonism of activation of hTRPV1 by capsaicin, low pH and elevated temperature but also displayed highly potent antagonism of activation of rTRPV1 by capsaicin.	Capsaicin	207-216	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	197-203
29504187-0	2018	Clinical testing of three novel transient receptor potential cation channel subfamily V member 1 antagonists in a pharmacodynamic intradermal capsaicin model.	Capsaicin	142-151	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-96
29698108-2	2018	In animals, capsaicin-based analgesic balm (CAP) attenuates the pressor response to muscle contraction, indicating the transient receptor potential vanilloid 1 (TRPv1) receptor (localized on the group IV afferent neuron) as an important mediator of the EPR.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	119-159
29698108-2	2018	In animals, capsaicin-based analgesic balm (CAP) attenuates the pressor response to muscle contraction, indicating the transient receptor potential vanilloid 1 (TRPv1) receptor (localized on the group IV afferent neuron) as an important mediator of the EPR.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	161-166
29399881-7	2018	Measurements of capsaicin-induced increase in dermal blood flow, within the region of interest, were performed by laser Doppler imaging (LDI) (reference method) and D-OCT.	Capsaicin	16-25	plexin A2	Homo sapiens	167-170
29732591-7	2018	Similarly, both capsaicin and a depolarizing solution of 60 mM KCl evoked CGRP release in saphenous but not vagus nerves.	Capsaicin	16-25	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	74-78
29806907-2	2018	Application of the TRPV1 activator capsaicin powerfully enhances spontaneous synaptic transmission in the hippocampal layers that are innervated by the axons of Cajal-Retzius cells.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
29806907-3	2018	Capsaicin-triggered calcium responses and membrane currents in Cajal-Retzius cells, as well as layer-specific modulation of spontaneous synaptic transmission, are absent when the drug is applied to slices prepared from TRPV1- /- animals.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	219-224
29806907-9	2018	Here, we have taken advantage of calcium imaging with the genetically encoded indicator GCaMP6s and patch-clamp techniques to study the responses of hippocampal CRs to the activation of TRPV1 by capsaicin, and have compared the effect of TRPV1 stimulation on synaptic transmission in layers innervated or non-innervated by CRs.	Capsaicin	195-204	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	186-191
29654770-5	2018	Transient ERK1/2 and p38 MAPK phosphorylation was detected within 1 min in the epithelium isolated from intact porcine lenses exposed to capsaicin (100 nM), a selective TRPV1 agonist, and the response was significantly inhibited by A889245 (1.0 muM), a TRPV1 antagonist.	Capsaicin	137-146	mitogen-activated protein kinase 1	Homo sapiens	21-24
30108548-6	2018	Dietary supplementation with TRPV1 agonists, such as capsaicin, has yielded conflicting results with some studies indicating a reduction in food intake and increase in energy expenditure, and other studies indicating the converse.	Capsaicin	53-62	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
30038260-6	2018	Our study provides a temporal mechanism for capsaicin activation of TRPV1.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
29352512-13	2018	SIGNIFICANCE: TRPV1 antagonists (of capsaicin activation) are highly unusual in that they can cause both hyper- and hypothermia by modulating the same mechanism.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
29689522-8	2018	Experiments performed in mouse dorsal root ganglion (DRG) neurons revealed that genetic ablation of Trpa1 did not abolish the responses to LPS, but remain detected in 30% of capsaicin-sensitive cells.	Capsaicin	174-183	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	100-105
29654770-3	2018	The presence of TRPV1 in the lens was evident from RT-PCR studies and Western blot analysis of MAPK signaling pathway activation caused by the TRPV1 agonist capsaicin.	Capsaicin	157-166	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-21
29654770-3	2018	The presence of TRPV1 in the lens was evident from RT-PCR studies and Western blot analysis of MAPK signaling pathway activation caused by the TRPV1 agonist capsaicin.	Capsaicin	157-166	mitogen-activated protein kinase 3	Homo sapiens	95-99
29654770-3	2018	The presence of TRPV1 in the lens was evident from RT-PCR studies and Western blot analysis of MAPK signaling pathway activation caused by the TRPV1 agonist capsaicin.	Capsaicin	157-166	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-148
29654770-5	2018	Transient ERK1/2 and p38 MAPK phosphorylation was detected within 1 min in the epithelium isolated from intact porcine lenses exposed to capsaicin (100 nM), a selective TRPV1 agonist, and the response was significantly inhibited by A889245 (1.0 muM), a TRPV1 antagonist.	Capsaicin	137-146	mitogen-activated protein kinase 3	Homo sapiens	10-16
29654770-5	2018	Transient ERK1/2 and p38 MAPK phosphorylation was detected within 1 min in the epithelium isolated from intact porcine lenses exposed to capsaicin (100 nM), a selective TRPV1 agonist, and the response was significantly inhibited by A889245 (1.0 muM), a TRPV1 antagonist.	Capsaicin	137-146	transient receptor potential cation channel subfamily V member 1	Homo sapiens	169-174
29654770-5	2018	Transient ERK1/2 and p38 MAPK phosphorylation was detected within 1 min in the epithelium isolated from intact porcine lenses exposed to capsaicin (100 nM), a selective TRPV1 agonist, and the response was significantly inhibited by A889245 (1.0 muM), a TRPV1 antagonist.	Capsaicin	137-146	latexin	Homo sapiens	245-248
29654770-5	2018	Transient ERK1/2 and p38 MAPK phosphorylation was detected within 1 min in the epithelium isolated from intact porcine lenses exposed to capsaicin (100 nM), a selective TRPV1 agonist, and the response was significantly inhibited by A889245 (1.0 muM), a TRPV1 antagonist.	Capsaicin	137-146	transient receptor potential cation channel subfamily V member 1	Homo sapiens	253-258
29654770-7	2018	Lenses pre-treated with either the cytosolic Ca2+ chelator BAPTA-AM or the PKC inhibitor sotrastaurin (1.0 muM) had a diminished ERK1/2 activation response to capsaicin and hyperosmotic solution.	Capsaicin	159-168	latexin	Homo sapiens	107-110
29654770-7	2018	Lenses pre-treated with either the cytosolic Ca2+ chelator BAPTA-AM or the PKC inhibitor sotrastaurin (1.0 muM) had a diminished ERK1/2 activation response to capsaicin and hyperosmotic solution.	Capsaicin	159-168	mitogen-activated protein kinase 3	Homo sapiens	129-135
29596157-0	2018	Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.	Capsaicin	171-180	transient receptor potential cation channel subfamily V member 1	Homo sapiens	86-91
30013731-0	2018	Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats.	Capsaicin	18-27	hypocretin neuropeptide precursor	Rattus norvegicus	0-8
30013731-0	2018	Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats.	Capsaicin	18-27	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	47-63
30013731-0	2018	Orexin-A inhibits capsaicin-induced changes in cyclooxygenase-2 and brain-derived neurotrophic factor expression in trigeminal nucleus caudalis of rats.	Capsaicin	18-27	brain-derived neurotrophic factor	Rattus norvegicus	68-101
30013731-8	2018	Results: The data indicated an increase in COX-2 and decrease in BDNF immuno-reactivity in the Vc of capsaicin, and capsaicin- pretreated with SB-334867-A (80 nM), groups of rat.	Capsaicin	101-110	brain-derived neurotrophic factor	Rattus norvegicus	65-69
30013731-9	2018	However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM).	Capsaicin	23-32	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	36-41
30013731-9	2018	However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM).	Capsaicin	23-32	brain-derived neurotrophic factor	Rattus norvegicus	46-50
30013731-9	2018	However, the effect of capsaicin on COX-2 and BDNF expressions was reversed by a Vc microinjection of orexin-A (100 pM).	Capsaicin	23-32	hypocretin neuropeptide precursor	Rattus norvegicus	102-110
30013731-10	2018	Conclusions: Overall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats.	Capsaicin	75-84	hypocretin neuropeptide precursor	Rattus norvegicus	52-60
30013731-10	2018	Conclusions: Overall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats.	Capsaicin	75-84	prostaglandin-endoperoxide synthase 2	Rattus norvegicus	151-156
30013731-10	2018	Conclusions: Overall, the present data reveals that orexin-A can attenuate capsaicin-induced trigeminal pain through the modulation of pain effects on COX-2 and BDNF expressions in the Vc of rats.	Capsaicin	75-84	brain-derived neurotrophic factor	Rattus norvegicus	161-165
29596157-0	2018	Machine-learned analysis of the association of next-generation sequencing-based human TRPV1 and TRPA1 genotypes with the sensitivity to heat stimuli and topically applied capsaicin.	Capsaicin	171-180	transient receptor potential cation channel subfamily A member 1	Homo sapiens	96-101
29596157-2	2018	A plausible cause is a genetic component, of which TRPV1 ion channels, by their response to both heat and capsaicin, are primary candidates.	Capsaicin	106-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
29735636-10	2018	HG-HF significantly depressed expression of PGC-1alpha (peroxisome proliferator-activated receptor-gamma coactivator-1alpha) and OPA1 (optic atrophy 1) by reducing [Ca2+]i, whereas OPA1 supplementation partly reversed those detrimental effects induced by TRPV1-/- Furthermore, capsaicin treatment not only attenuated CMECs injury induced by HG-HF but also mitigated cardiac microvascular injury induced by T2DM.	Capsaicin	277-286	PPARG coactivator 1 alpha	Homo sapiens	44-54
29735636-12	2018	Long-term capsaicin can protect cardiac microvessels against T2DM via suppressing oxidative/nitrative stress mediated by TRPV1/Ca2+/PGC-1alpha/OPA1 pathway in CMECs.	Capsaicin	10-19	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-126
29735636-12	2018	Long-term capsaicin can protect cardiac microvessels against T2DM via suppressing oxidative/nitrative stress mediated by TRPV1/Ca2+/PGC-1alpha/OPA1 pathway in CMECs.	Capsaicin	10-19	PPARG coactivator 1 alpha	Homo sapiens	132-142
29735636-12	2018	Long-term capsaicin can protect cardiac microvessels against T2DM via suppressing oxidative/nitrative stress mediated by TRPV1/Ca2+/PGC-1alpha/OPA1 pathway in CMECs.	Capsaicin	10-19	OPA1 mitochondrial dynamin like GTPase	Homo sapiens	143-147
29730242-2	2018	We analysed the modulation of capsaicin (CAP)-induced neurogenic inflammation in the rat hind paw by the selective 5-HT7 receptor agonist, LP-44, and the involvement of calcitonin gen-related peptide (CGRP) in this effect.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	201-205
29730242-8	2018	Finally, the non-peptide CGRP receptor antagonist, BIBN4096 (3 mg/kg, s.c.), strongly inhibited the potentiated inflammatory responses induced by LP-44 (7.5 and 15 nmol) + CAP (0.1%) thus substantiating their neurogenic nature.	Capsaicin	172-175	calcitonin-related polypeptide alpha	Rattus norvegicus	25-29
29977195-3	2018	The present article explored this issue by assessing the effect of capsaicin, which activates C-fibers that express the transient receptor potential vanilloid receptor-1 (TRPV1).	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-169
29730242-9	2018	Thus, sensitization of CAP-sensitive primary sensory neurons by 5-HT7 receptors may result in facilitation of neurogenic inflammation involving CGRP in the rat hind paw.	Capsaicin	23-26	calcitonin-related polypeptide alpha	Rattus norvegicus	144-148
29953534-7	2018	Approximately 30% of total cells responded to capsaicin, indicating that they expressed an active TRPV1 channel.	Capsaicin	46-55	transient receptor potential cation channel subfamily V member 1	Homo sapiens	98-103
29977195-3	2018	The present article explored this issue by assessing the effect of capsaicin, which activates C-fibers that express the transient receptor potential vanilloid receptor-1 (TRPV1).	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	171-176
29915934-2	2018	In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated with the release of the migraine mediator CGRP has already been widely used.	Capsaicin	41-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
29915934-2	2018	In testing of the antimigraine drugs the capsaicin-induced skin redness with activated TRPV1 receptors in sensory neurons associated with the release of the migraine mediator CGRP has already been widely used.	Capsaicin	41-50	calcitonin related polypeptide alpha	Homo sapiens	175-179
29660342-4	2018	Capsaicin-induced [Ca2+]i changes in small diameter DRG neurons were significantly diminished in TRPV1 Leu206Stop mice and administration of capsaicin induced neither hypothermia nor nocifensive behaviour in vivo.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	97-102
29922176-4	2018	TRPV1 is activated by pain-inducing stimuli, including inflammatory endovanilloids and pungent exovanilloids, such as capsaicin (CAP).	Capsaicin	118-127	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
29922176-4	2018	TRPV1 is activated by pain-inducing stimuli, including inflammatory endovanilloids and pungent exovanilloids, such as capsaicin (CAP).	Capsaicin	129-132	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
29922176-5	2018	TRPV1 activation by high doses of CAP (&gt;10 muM) leads to necrosis, but also exhibits apoptotic characteristics.	Capsaicin	34-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
29922176-5	2018	TRPV1 activation by high doses of CAP (&gt;10 muM) leads to necrosis, but also exhibits apoptotic characteristics.	Capsaicin	34-37	latexin	Homo sapiens	46-49
29922176-10	2018	Low concentrations of CAP (1 muM) induce cell death by a mechanism involving a TRPV1-mediated rapid and transient intracellular Ca2+ increase that stimulates plasma membrane depolarization, thereby compromising plasma membrane integrity and ultimately leading to cell death.	Capsaicin	22-25	latexin	Homo sapiens	29-32
29922176-10	2018	Low concentrations of CAP (1 muM) induce cell death by a mechanism involving a TRPV1-mediated rapid and transient intracellular Ca2+ increase that stimulates plasma membrane depolarization, thereby compromising plasma membrane integrity and ultimately leading to cell death.	Capsaicin	22-25	transient receptor potential cation channel subfamily V member 1	Homo sapiens	79-84
29922176-11	2018	Meanwhile, higher doses of CAP induce cell death via a TRPV1-independent mechanism, involving a slow and persistent intracellular Ca2+ increase that induces mitochondrial dysfunction, plasma membrane depolarization, plasma membrane loss of integrity, and ultimately, cell death.	Capsaicin	27-30	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-60
29577893-11	2018	Moreover, 24 h after its injection, paclitaxel induced chemical hypersensitivity to capsaicin (a TRPV1 agonist, 0.01 nmol/site) and increased TRPV1 immunoreactivity in the dorsal root ganglion and sciatic nerve.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	97-102
29660342-7	2018	TRPV1 knockout mice have been reported to carry a similar phenotype regarding capsaicin-evoked responses in vitro and in vivo.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
29660342-9	2018	In summary, these data revealed a target-related (i.e. capsaicin-evoked) phenotype of TRPV1 Leu206Stop mice closely resembling that of published TRPV1 knockout mice.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
28924972-4	2018	TRPV1 channel antagonists have suffered from side effects related to the channel"s role in temperature sensation; however, high dose formulations of capsaicin have reached the market and shown therapeutic utility.	Capsaicin	149-158	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
29661478-7	2018	Capsaicin- and acrolein-induced CGRP release was measured with enzyme-linked immunoassay in an ex vivo dura mater preparation.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	32-36
29159769-6	2018	The study of intracellular signaling suggested that the transient receptor potential vanilloid 1 (TRPV1) and cannabinoid receptors in the soleus muscle were more sensitive to capsaicin.	Capsaicin	175-184	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-96
29159769-6	2018	The study of intracellular signaling suggested that the transient receptor potential vanilloid 1 (TRPV1) and cannabinoid receptors in the soleus muscle were more sensitive to capsaicin.	Capsaicin	175-184	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
29596901-6	2018	A sub-effective dose of NMDA (25 pmol) was potentiated by the TRPV1 receptor agonist capsaicin (CAP, 1 nmol) and the CB1 receptor antagonist, AM251 (200 pmol).	Capsaicin	85-94	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-67
29596901-6	2018	A sub-effective dose of NMDA (25 pmol) was potentiated by the TRPV1 receptor agonist capsaicin (CAP, 1 nmol) and the CB1 receptor antagonist, AM251 (200 pmol).	Capsaicin	85-94	cyclase associated actin cytoskeleton regulatory protein 1	Rattus norvegicus	96-102
29991229-8	2018	Meanwhile, phenylephrine-induced relaxation was inhibited by pretreatment with propranolol and calcitonin gene-related peptide (CGRP)-depletory capsaicin in UB strips with and without mucosa.	Capsaicin	144-153	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	95-126
29685681-1	2018	Capsaicin (CAP), the prototypical TRPV1 agonist, is the major active component in chili peppers with health-promoting benefits.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
29991229-8	2018	Meanwhile, phenylephrine-induced relaxation was inhibited by pretreatment with propranolol and calcitonin gene-related peptide (CGRP)-depletory capsaicin in UB strips with and without mucosa.	Capsaicin	144-153	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	128-132
29991230-12	2018	c-fos-positive cells decreased in the capsaicin-pretreated group.	Capsaicin	38-47	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
29573663-0	2018	Capsaicin protects against testicular torsion injury through mTOR-dependent mechanism.	Capsaicin	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	61-65
29573663-4	2018	In present work, we evaluated the role of the mammalian target of rapamycin (mTOR) in antioxidant effect of capsaicin against reperfusion injury following testicular torsion.	Capsaicin	108-117	mechanistic target of rapamycin kinase	Homo sapiens	46-75
29573663-4	2018	In present work, we evaluated the role of the mammalian target of rapamycin (mTOR) in antioxidant effect of capsaicin against reperfusion injury following testicular torsion.	Capsaicin	108-117	mechanistic target of rapamycin kinase	Homo sapiens	77-81
29573663-9	2018	Capsaicin administration remarkably decreased the phosphorylation of mTOR at the highest dose (P &lt; 0.05).	Capsaicin	0-9	mechanistic target of rapamycin kinase	Rattus norvegicus	69-73
29813107-12	2018	The differential effect of GLP-1R agonists on capsaicin and ATP responses in neurons suggest they may not affect pain mechanisms mediated by the capsaicin receptor TRPV1, but may enhance the effects of purinergic agonists.	Capsaicin	46-55	glucagon like peptide 1 receptor	Homo sapiens	27-33
29722529-3	2018	The implanting of an ester group in the lipophilic moiety of capsaicinoids by the Passerini multicomponent reaction affords both agonists and antagonists that retain transient receptor potential vanilloid 1 channel (TRPV1) modulating activity and, at the same time, are susceptible to hydrolysis.	Capsaicin	61-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	216-221
29772784-1	2018	Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-116
29772784-1	2018	Capsaicin, the major active constituent of chilli, is an agonist on transient receptor potential vanilloid channel 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-69
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	peroxisome proliferator activated receptor alpha	Homo sapiens	223-271
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	peroxisome proliferator activated receptor alpha	Homo sapiens	273-282
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	uncoupling protein 1	Homo sapiens	285-305
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	uncoupling protein 1	Homo sapiens	307-311
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	glucagon	Homo sapiens	318-341
29772784-5	2018	These responses of capsaicin are mediated through activation of TRPV1, which can then modulate processes such as browning of adipocytes, and activation of metabolic modulators including AMP-activated protein kinase (AMPK), peroxisome proliferator-activated receptor alpha (PPARalpha), uncoupling protein 1 (UCP1), and glucagon-like peptide 1 (GLP-1).	Capsaicin	19-28	glucagon	Homo sapiens	343-348
29772784-7	2018	Identifying suitable ways of administering capsaicin at an effective dose would warrant its clinical use through the activation of TRPV1.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	131-136
29854941-0	2018	TRPV1 Agonist, Capsaicin, Induces Axon Outgrowth after Injury via Ca2+/PKA Signaling.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
29854941-4	2018	We show that activating the ion channel TRPV1 with capsaicin induces axon outgrowth of cultured dorsal root ganglion (DRG) sensory neurons, and that this effect is blocked in TRPV1 knockout neurons.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-45
29854941-4	2018	We show that activating the ion channel TRPV1 with capsaicin induces axon outgrowth of cultured dorsal root ganglion (DRG) sensory neurons, and that this effect is blocked in TRPV1 knockout neurons.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	175-180
29685681-1	2018	Capsaicin (CAP), the prototypical TRPV1 agonist, is the major active component in chili peppers with health-promoting benefits.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
29425725-5	2018	In particular, we (i) support the previously proposed mechanism driving thermal actuation in the extracellular pore of TRPV1, (ii) present new hypotheses regarding the thermal actuation in the C-terminal and adjacent linker domains, and (iii) support and build upon the existing hypothesis regarding the role of the vanilloid binding pocket and lipids embedded therein.	Capsaicin	316-325	transient receptor potential cation channel subfamily V member 1	Homo sapiens	119-124
29746471-7	2018	We previously showed that although schistosomes contain no genes predicted to encode TRPV channels, TRPV1-selective activators such as capsaicin and resiniferatoxin elicit dramatic hyperactivity in adult worms and schistosomula.	Capsaicin	135-144	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
29746471-9	2018	Here, we show that capsaicin induces a rise in intracellular Ca2+ in mammalian cells expressing either SmTRPA or a S. haematobium TRPA1 orthologue (ShTRPA).	Capsaicin	19-28	transient receptor potential cation channel subfamily A member 1	Homo sapiens	130-135
29740093-5	2018	On days 7&14 post-MIA, but not day 28, QX-314 + capsaicin signficantly attenuated changes in WB induced by MIA, illustrating a crucial role for TRPV1 expressing nociceptors in early OA pain.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-149
29377430-6	2018	RESULTS: In vitro, all three compounds were effective at inhibiting capsaicin-activated TRPV1.	Capsaicin	68-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
29368950-0	2018	High-concentration topical capsaicin in the management of refractory neuropathic pain in patients with neurofibromatosis type 1: a case series.	Capsaicin	27-36	neurofibromin 1	Homo sapiens	103-127
29368950-1	2018	AIM: The aim of this case series was to report the use of 8% topical capsaicin patch (marketed under the trade name Qutenza ) a in the management of refractory neuropathic pain (NP) in adult patients with type 1 neurofibromatosis (NF1).	Capsaicin	69-78	neurofibromin 1	Homo sapiens	231-234
29368950-2	2018	METHODS: Capsaicin has been suggested for NF1 patients suffering from refractory peripheral NP despite several years of analgesic treatments.	Capsaicin	9-18	neurofibromin 1	Homo sapiens	42-45
29368950-12	2018	CONCLUSIONS: As suggested in this case series, capsaicin provided pain relief in certain NF1 patients with resistant NP.	Capsaicin	47-56	neurofibromin 1	Homo sapiens	89-92
29689050-2	2018	Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors.	Capsaicin	51-60	pro-opiomelanocortin-alpha	Mus musculus	30-34
29305649-4	2018	In particular, several temperature-sensitive members of the transient receptor potential (TRP) superfamily of ion channels have been identified, and a multitude of in vivo studies have shown that the capsaicin-sensitive TRPV1 channel plays a key role as a noxious heat sensor.	Capsaicin	200-209	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	220-225
28205139-6	2018	CGRP potentiated capsaicin-induced increase in phosphorylated CaMKII levels in the TG organ cultures.	Capsaicin	17-26	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
28205139-7	2018	The incubation of the trigeminal neurons with CGRP significantly increased the inward currents in response to capsaicin challenge, and this effect was inhibited by co-incubation with the CGRP receptor antagonist, BIBN4068BS or the inhibitor of protein kinase A, H-89.	Capsaicin	110-119	calcitonin-related polypeptide alpha	Rattus norvegicus	46-50
28205139-7	2018	The incubation of the trigeminal neurons with CGRP significantly increased the inward currents in response to capsaicin challenge, and this effect was inhibited by co-incubation with the CGRP receptor antagonist, BIBN4068BS or the inhibitor of protein kinase A, H-89.	Capsaicin	110-119	calcitonin-related polypeptide alpha	Rattus norvegicus	187-191
29689050-2	2018	Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	71-120
29689050-2	2018	Here, we demonstrate that ARC POMC neurons express capsaicin-sensitive transient receptor potential vanilloid 1 receptor (TRPV1)-like receptors.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	122-127
29452097-6	2018	We identified the AP-1 DNA binding site as the capsaicin/resiniferatoxin-responsive element.	Capsaicin	47-56	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	18-22
29670121-3	2018	TRPV1 is SUMOylated at a C-terminal Lys residue (K822), which specifically enhances the channel sensitivity to stimulation by heat, but not capsaicin, protons or voltage.	Capsaicin	140-149	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
29452097-1	2018	Transient receptor potential vanilloid 1 (TRPV1) channels were originally described as the receptors of capsaicin, the main constituent of hot chili pepper.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
29452097-8	2018	Stimulation of TRPV1 channels induced an influx of Ca2+ into the cells and this rise in intracellular Ca2+ was essential for activating AP-1 in capsaicin or resiniferatoxin-stimulated cells.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
29452097-3	2018	Here, we show that stimulation of HEK293 cells expressing TRPV1 channels (H2C1 cells) with capsaicin or the TRPV1 ligand resiniferatoxin activated transcription mediated by the transcription factor AP-1.	Capsaicin	91-100	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
29452097-3	2018	Here, we show that stimulation of HEK293 cells expressing TRPV1 channels (H2C1 cells) with capsaicin or the TRPV1 ligand resiniferatoxin activated transcription mediated by the transcription factor AP-1.	Capsaicin	91-100	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	198-202
29452097-8	2018	Stimulation of TRPV1 channels induced an influx of Ca2+ into the cells and this rise in intracellular Ca2+ was essential for activating AP-1 in capsaicin or resiniferatoxin-stimulated cells.	Capsaicin	144-153	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	136-140
29452097-11	2018	Stimulation of TRPV1 channels with capsaicin increased c-Jun and c-Fos biosynthesis in H2C1 cells.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
29452097-11	2018	Stimulation of TRPV1 channels with capsaicin increased c-Jun and c-Fos biosynthesis in H2C1 cells.	Capsaicin	35-44	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	55-60
29452097-11	2018	Stimulation of TRPV1 channels with capsaicin increased c-Jun and c-Fos biosynthesis in H2C1 cells.	Capsaicin	35-44	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	65-70
29452097-12	2018	The signal transduction of capsaicin, leading to enhanced AP-1-mediated transcription, required extracellular signal-regulated protein kinase ERK1/2 as a signal transducer and the activation of the transcription factors c-Jun and ternary complex factor.	Capsaicin	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	58-62
29452097-12	2018	The signal transduction of capsaicin, leading to enhanced AP-1-mediated transcription, required extracellular signal-regulated protein kinase ERK1/2 as a signal transducer and the activation of the transcription factors c-Jun and ternary complex factor.	Capsaicin	27-36	mitogen-activated protein kinase 3	Homo sapiens	142-148
29452097-12	2018	The signal transduction of capsaicin, leading to enhanced AP-1-mediated transcription, required extracellular signal-regulated protein kinase ERK1/2 as a signal transducer and the activation of the transcription factors c-Jun and ternary complex factor.	Capsaicin	27-36	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	220-225
29328505-1	2018	BACKGROUND AND PURPOSE: Capsaicin-mediated modulation of taste nerve responses is thought to be produced indirectly by the actions of neuropeptides, for example, CGRP and substance P (SP), on taste cells implying they play a role in taste sensitivity.	Capsaicin	24-33	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	162-166
29808083-9	2018	Moreover, the number of capsaicin-responding neurons and the magnitude of evoked calcium response were attenuated in DRG neurons from Pirt-/- mice in CCI models.	Capsaicin	24-33	phosphoinositide-interacting regulator of transient receptor potential channels	Mus musculus	134-138
29328505-1	2018	BACKGROUND AND PURPOSE: Capsaicin-mediated modulation of taste nerve responses is thought to be produced indirectly by the actions of neuropeptides, for example, CGRP and substance P (SP), on taste cells implying they play a role in taste sensitivity.	Capsaicin	24-33	tachykinin 1	Mus musculus	171-182
29328505-1	2018	BACKGROUND AND PURPOSE: Capsaicin-mediated modulation of taste nerve responses is thought to be produced indirectly by the actions of neuropeptides, for example, CGRP and substance P (SP), on taste cells implying they play a role in taste sensitivity.	Capsaicin	24-33	tachykinin 1	Mus musculus	184-186
29131694-5	2018	Daily administration of Gap26, a Cx43 mimetic peptide and inhibitor, in the TG significantly suppressed the enhancement of capsaicin-induced D-EMG activity and the percentage of Fluoro-Gold (FG)-labeled cells encircled by glial fibrillary acid protein-immunoreactive (IR) + Cx43-IR cells after M1 pulp inflammation ( P &lt; 0.01).	Capsaicin	123-132	gap junction protein, alpha 1	Rattus norvegicus	33-37
29509988-6	2018	Lgr6 persisted in the interfollicular epidermis of capsaicin-injected rats beyond 3 weeks after birth, indicating that capsaicin-induced skin manifestations were influenced by postnatal epidermal development.	Capsaicin	51-60	leucine-rich repeat-containing G protein-coupled receptor 6	Rattus norvegicus	0-4
29509988-6	2018	Lgr6 persisted in the interfollicular epidermis of capsaicin-injected rats beyond 3 weeks after birth, indicating that capsaicin-induced skin manifestations were influenced by postnatal epidermal development.	Capsaicin	119-128	leucine-rich repeat-containing G protein-coupled receptor 6	Rattus norvegicus	0-4
29509988-7	2018	Capsaicin injection induced alteration of proteolytic processing of filaggrin and corneodesmosin, suggesting epidermal barrier dysfunction.	Capsaicin	0-9	corneodesmosin	Rattus norvegicus	82-96
29509988-10	2018	These results strongly suggest that capsaicin may dysregulate the protease system, resulting in alteration of profilaggrin and corneodesmosin proteolysis and skin manifestations.	Capsaicin	36-45	corneodesmosin	Rattus norvegicus	127-141
29131694-7	2018	Daily administration of IL-1ra, an IL-1 receptor antagonist, into the TG significantly reduced the enhancement of capsaicin-induced D-EMG activity and the percentage of TRPV1-IR neurons labeled with FG after M1 pulp inflammation ( P &lt; 0.01).	Capsaicin	114-123	interleukin 1 receptor antagonist	Rattus norvegicus	24-30
29436634-0	2018	Capsaicin inhibits glycolysis in esophageal squamous cell carcinoma by regulating hexokinase-2 expression.	Capsaicin	0-9	hexokinase 2	Homo sapiens	82-94
29436634-6	2018	Capsaicin resulted in a decrease of hexokinase-2 (HK-2) expression, which is known for its important role in tumor glycolysis.	Capsaicin	0-9	hexokinase 2	Homo sapiens	36-48
29436634-6	2018	Capsaicin resulted in a decrease of hexokinase-2 (HK-2) expression, which is known for its important role in tumor glycolysis.	Capsaicin	0-9	hexokinase 2	Homo sapiens	50-54
29436634-7	2018	Further investigations demonstrated that phosphatase and tensin homolog (PTEN) expression was increased in ESCC cells treated with capsaicin, and that the RAC-alpha serine threonine-protein kinase signaling pathway was downregulated.	Capsaicin	131-140	phosphatase and tensin homolog	Homo sapiens	73-77
29436634-8	2018	In PTEN-knockdown KYSE150 cells, the decrease in HK-2 and inhibition of glycolysis caused by capsaicin was attenuated, which suggested that the impact of capsaicin on tumor metabolism was associated with its effect on PTEN.	Capsaicin	93-102	phosphatase and tensin homolog	Homo sapiens	3-7
29436634-8	2018	In PTEN-knockdown KYSE150 cells, the decrease in HK-2 and inhibition of glycolysis caused by capsaicin was attenuated, which suggested that the impact of capsaicin on tumor metabolism was associated with its effect on PTEN.	Capsaicin	154-163	phosphatase and tensin homolog	Homo sapiens	3-7
29436634-8	2018	In PTEN-knockdown KYSE150 cells, the decrease in HK-2 and inhibition of glycolysis caused by capsaicin was attenuated, which suggested that the impact of capsaicin on tumor metabolism was associated with its effect on PTEN.	Capsaicin	154-163	hexokinase 2	Homo sapiens	49-53
29436634-8	2018	In PTEN-knockdown KYSE150 cells, the decrease in HK-2 and inhibition of glycolysis caused by capsaicin was attenuated, which suggested that the impact of capsaicin on tumor metabolism was associated with its effect on PTEN.	Capsaicin	154-163	phosphatase and tensin homolog	Homo sapiens	218-222
29427180-7	2018	In IgG192/LV-VR1-injected rats, the behavioral response to capsaicin exposure as well as Erk 1/2 phosphorylation and VR1 current activation by capsaicin were significantly reduced.	Capsaicin	59-68	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-16
29427180-7	2018	In IgG192/LV-VR1-injected rats, the behavioral response to capsaicin exposure as well as Erk 1/2 phosphorylation and VR1 current activation by capsaicin were significantly reduced.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-16
29427180-7	2018	In IgG192/LV-VR1-injected rats, the behavioral response to capsaicin exposure as well as Erk 1/2 phosphorylation and VR1 current activation by capsaicin were significantly reduced.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	117-120
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	Capsaicin	57-66	ATP binding cassette subfamily B member 1	Homo sapiens	236-250
29520110-0	2018	Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice.	Capsaicin	0-9	histone deacetylase 2	Mus musculus	22-27
29520110-0	2018	Capsaicin upregulates HDAC2 via TRPV1 and impairs neuronal maturation in mice.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	32-37
29520110-2	2018	In the present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling and thereby altered gene expression related to synaptic plasticity.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	111-116
29520110-2	2018	In the present study we investigated whether capsaicin (8-methyl-N-vanillyl-trans-6-nonenamide), an agonist of TRPV1, induced chromatin remodeling and thereby altered gene expression related to synaptic plasticity.	Capsaicin	56-94	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	111-116
29520110-3	2018	We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters.	Capsaicin	14-23	histone deacetylase 2	Mus musculus	62-83
29520110-3	2018	We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters.	Capsaicin	14-23	histone deacetylase 2	Mus musculus	85-90
29520110-3	2018	We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters.	Capsaicin	14-23	histone deacetylase 2	Mus musculus	121-126
29520110-3	2018	We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters.	Capsaicin	14-23	synaptophysin	Mus musculus	150-163
29520110-3	2018	We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters.	Capsaicin	14-23	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	165-170
29520110-3	2018	We found that capsaicin treatment resulted in upregulation of histone deacetylase 2 (HDAC2) in the mouse hippocampus and HDAC2 was enriched at Psd95, synaptophysin, GLUR1, GLUR2 promoters.	Capsaicin	14-23	glutamate receptor, ionotropic, AMPA2 (alpha 2)	Mus musculus	172-177
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	120-129	histone deacetylase 2	Mus musculus	40-45
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	120-129	synapsin I	Mus musculus	133-143
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	120-129	synapsin I	Mus musculus	133-143
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	210-219	histone deacetylase 2	Mus musculus	40-45
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	210-219	synapsin I	Mus musculus	68-78
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	210-219	synapsin I	Mus musculus	133-143
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	210-219	histone deacetylase 2	Mus musculus	187-192
29520110-4	2018	Viral-mediated hippocampal knockdown of HDAC2 induced expression of Synapsin I and prevented the detrimental effects of capsaicin on Synapsin I expression in mice, supporting the role of HDAC2 in regulation of capsaicin-induced Synapsin I expression.	Capsaicin	210-219	synapsin I	Mus musculus	133-143
29520110-5	2018	Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity.	Capsaicin	48-57	histone deacetylase 2	Mus musculus	39-44
29520110-5	2018	Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity.	Capsaicin	48-57	histone deacetylase 2	Mus musculus	141-146
29520110-5	2018	Taken together, our findings implicate HDAC2 in capsaicin-induced transcriptional regulation of synaptic molecules and support the view that HDAC2 is a molecular link between TRPV1 activity and synaptic plasticity.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	175-180
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	Capsaicin	57-66	ATP binding cassette subfamily B member 1	Homo sapiens	252-256
29498663-2	2018	We analyzed the ability of two pungent-tasting alkaloids-capsaicin and piperine from Capsicum frutescens and Piper nigrum, respectively-to reverse multidrug resistance in the cancer cell lines Caco-2 and CEM/ADR 5000, which overexpress P-glycoprotein (P-gp) and other ABC transporters.	Capsaicin	57-66	ATP binding cassette subfamily B member 6 (Langereis blood group)	Homo sapiens	268-271
29498663-6	2018	Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines.	Capsaicin	13-22	ATP binding cassette subfamily B member 1	Homo sapiens	96-110
29498663-6	2018	Furthermore, capsaicin and piperine increased the intracellular accumulation of the fluorescent P-glycoprotein (P-gp) substrates rhodamine and calcein and inhibited their efflux from the MDR cell lines.	Capsaicin	13-22	ATP binding cassette subfamily B member 1	Homo sapiens	112-116
29498663-7	2018	CONCLUSION: Our study has demonstrated that capsaicin and piperine are P-gp substrates and have potential chemosensitizing activity, which might be interesting for the development of novel modulators of multidrug resistance.	Capsaicin	44-53	ATP binding cassette subfamily B member 1	Homo sapiens	71-75
29478714-7	2018	Sensory deafferentation evoked by pretreatment with high doses of capsaicin markedly exacerbated DSS-induced colitis with reductions in DSS-induced upregulation of SP- and CGRP-positive nerve fibers.	Capsaicin	66-75	tachykinin 1	Mus musculus	164-166
29188798-10	2018	Taken together, our results suggest that capsaicin-increased phosphorylation of ERK contributes to the enhanced antitumor activity of sorafenib, and capsaicin may be useful in improving the efficacy of sorafenib for the treatment of HCC.	Capsaicin	41-50	Eph receptor B2	Mus musculus	80-83
29188798-0	2018	Capsaicin enhances the antitumor activity of sorafenib in hepatocellular carcinoma cells and mouse xenograft tumors through increased ERK signaling.	Capsaicin	0-9	Eph receptor B2	Mus musculus	134-137
29188798-3	2018	Capsaicin, the major active component of chili peppers from the genus Capsicum, is not only the agonist of TRPV1 channel, but also displays antitumor activity and enhances the sensitivity of cancer cells to cytotoxic drugs.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
29188798-5	2018	Treatment with capsaicin alone dose-dependently inhibited the proliferation of the HCC cell lines PLC/PRF/7, HuH7 and HepG2 with IC50 values of 137, 108 and 140.7 mumol/L, respectively.	Capsaicin	15-24	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	98-101
29188798-8	2018	In nude mice with PLC/PRF/5 xenografts, combined administration of capsaicin and sorafenib significantly enhanced the suppression on tumor growth without apparent gross toxicity compared to either agent alone.	Capsaicin	67-76	perlecan (heparan sulfate proteoglycan 2)	Mus musculus	18-21
29188798-9	2018	Mechanistically, capsaicin (10-200 mumol/L) dose-dependently increased the levels of phosphorylated ERK (p-ERK) in PLC/PRF/5 cells, thus leading to enhanced sorafenib sensitivity and a synergistic suppression on the tumor cells.	Capsaicin	17-26	EPH receptor B2	Homo sapiens	100-103
29188798-9	2018	Mechanistically, capsaicin (10-200 mumol/L) dose-dependently increased the levels of phosphorylated ERK (p-ERK) in PLC/PRF/5 cells, thus leading to enhanced sorafenib sensitivity and a synergistic suppression on the tumor cells.	Capsaicin	17-26	Eph receptor B2	Mus musculus	107-110
29188798-9	2018	Mechanistically, capsaicin (10-200 mumol/L) dose-dependently increased the levels of phosphorylated ERK (p-ERK) in PLC/PRF/5 cells, thus leading to enhanced sorafenib sensitivity and a synergistic suppression on the tumor cells.	Capsaicin	17-26	heparan sulfate proteoglycan 2	Homo sapiens	115-118
29790024-1	2018	Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	137-142
29790024-1	2018	Evidence obtained by immunohistochemical double labeling and confocal laser scanning microscopy suggests that capsaicin, a ligand of the TRPV1 nociceptive vanilloid receptor, increases the number of TLR4-positive neurons in the rat colon myenteric plexus.	Capsaicin	110-119	toll-like receptor 4	Rattus norvegicus	199-203
29478714-7	2018	Sensory deafferentation evoked by pretreatment with high doses of capsaicin markedly exacerbated DSS-induced colitis with reductions in DSS-induced upregulation of SP- and CGRP-positive nerve fibers.	Capsaicin	66-75	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	172-176
29378958-4	2018	Antagonism of Sig-1R by progesterone results in the down-regulation of TRPV1 expression in the plasma membrane of sensory neurons and, consequently, a decrease in capsaicin-induced nociceptive responses.	Capsaicin	163-172	sigma non-opioid intracellular receptor 1	Homo sapiens	14-20
29421065-6	2018	Capsaicin pretreatment induced profound loss of warmth and heat pain sensitivity (pain threshold and supra-threshold ratings) as assessed by quantitative sensory testing, indicative of efficient TRPV1-fiber defunctionalization (all outcomes: P&lt;0.0001).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	195-200
29362767-5	2018	Energy-producing pathways, as indicated by the reduced mitochondrial oxygen consumption and reduced glucose and fatty acid uptake, were diminished after incubation with both capsaicinoids at a concentration of 100 muM.	Capsaicin	174-187	latexin	Homo sapiens	214-217
29362767-9	2018	These findings provide evidence that concentrations of capsaicin and nonivamide between 0.1 and 100 muM modulate the mechanisms of cellular energy metabolism to a similar extent, independent of the investigated tissue.	Capsaicin	55-64	latexin	Homo sapiens	100-103
29317149-4	2018	In the TRPV1 functional assay, using cells expressed hTRPV1, 37 antagonized capsaicin-induced Ca2+ influx, with an IC50 value of 10.2 nM.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	7-12
29317149-4	2018	In the TRPV1 functional assay, using cells expressed hTRPV1, 37 antagonized capsaicin-induced Ca2+ influx, with an IC50 value of 10.2 nM.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-59
29335353-6	2018	Moreover, intraplantar injection of TAT-31-50 attenuated the capsaicin-evoked spontaneous pain behavior and thermal hyperalgesia, which further strengthened the regulatory role of TAT-31-50 on TRPV1 channel.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	193-198
29342359-3	2018	The organic nanoagonists comprise semiconducting polymer nanoparticles (SPNs) and capsaicin (Cap) as the photothermally responsive nanocarrier and the agonist for activation of transient receptor potential cation channel subfamily V member 1 (TRPV1), respectively.	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	177-241
29378958-4	2018	Antagonism of Sig-1R by progesterone results in the down-regulation of TRPV1 expression in the plasma membrane of sensory neurons and, consequently, a decrease in capsaicin-induced nociceptive responses.	Capsaicin	163-172	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
29132924-2	2018	Capsaicin, a component of chili pepper, which can stimulate actin remodeling via capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) and anti-inflammatory effects via PPARgamma (peroxisome proliferator-activated receptor-gamma) and LXRalpha (liver X receptor alpha), is a potential candidate to control chlamydial growth in host cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
29414892-4	2018	This study aimed to test the hypothesis that phytochemical P-gp inhibitors, i.e., piperine, capsaicin and [6]-gingerol, modulate the in vivo tissue distribution of doxorubicin, a representative P-gp substrate.	Capsaicin	92-101	phosphoglycolate phosphatase	Mus musculus	59-63
29414892-4	2018	This study aimed to test the hypothesis that phytochemical P-gp inhibitors, i.e., piperine, capsaicin and [6]-gingerol, modulate the in vivo tissue distribution of doxorubicin, a representative P-gp substrate.	Capsaicin	92-101	phosphoglycolate phosphatase	Mus musculus	194-198
29396565-0	2018	TRPA1-dependent reversible opening of tight junction by natural compounds with an alpha,beta-unsaturated moiety and capsaicin.	Capsaicin	116-125	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	0-5
29396565-8	2018	Furthermore, our analyses revealed that TRPA1 is involved in the Ca2+ influx and TJ permeability increase not only by an alpha,beta-unsaturated compound but also by capsaicin.	Capsaicin	165-174	transient receptor potential cation channel subfamily A member 1	Canis lupus familiaris	40-45
29411905-0	2018	FOXO1 targeting by capsaicin reduces tissue damage after testicular torsion.	Capsaicin	19-28	forkhead box O1	Rattus norvegicus	0-5
29411905-5	2018	Likewise, the expression of FOXO1 is significantly increased by higher doses of the capsaicin.	Capsaicin	84-93	forkhead box O1	Rattus norvegicus	28-33
29411905-7	2018	These results suggested clinical potential for capsaicin in treatment of testicular torsion by targeting FOXO1 and apoptotic pathways.	Capsaicin	47-56	forkhead box O1	Rattus norvegicus	105-110
29294454-7	2018	Additionally, the NMU exposure and capsaicin treated group significantly showed the protective potential of capsaicin in restoring the altered sexual hormones, antioxidants and other biochemical analyses.	Capsaicin	108-117	neuromedin U	Rattus norvegicus	18-21
29294454-8	2018	Rats treated with NMU and protected with capsaicin improved the histopathological changes induced by NMU and showed that the desquamation of most of the layers of carcinoma cells leaving one or two epithelial layers in some cases and in some instances.	Capsaicin	41-50	neuromedin U	Rattus norvegicus	101-104
29294454-9	2018	Animals treated with NMU immunostained for PCNA displayed the strong positive stained nuclei in most of the cells, but in capsaicin treated against the NMU effects immunostained for PCNA displayed that the positive stained nuclei was less than that detected in NMU group.	Capsaicin	122-131	neuromedin U	Rattus norvegicus	21-24
29294454-9	2018	Animals treated with NMU immunostained for PCNA displayed the strong positive stained nuclei in most of the cells, but in capsaicin treated against the NMU effects immunostained for PCNA displayed that the positive stained nuclei was less than that detected in NMU group.	Capsaicin	122-131	neuromedin U	Rattus norvegicus	152-155
29294454-9	2018	Animals treated with NMU immunostained for PCNA displayed the strong positive stained nuclei in most of the cells, but in capsaicin treated against the NMU effects immunostained for PCNA displayed that the positive stained nuclei was less than that detected in NMU group.	Capsaicin	122-131	proliferating cell nuclear antigen	Rattus norvegicus	182-186
29294454-9	2018	Animals treated with NMU immunostained for PCNA displayed the strong positive stained nuclei in most of the cells, but in capsaicin treated against the NMU effects immunostained for PCNA displayed that the positive stained nuclei was less than that detected in NMU group.	Capsaicin	122-131	neuromedin U	Rattus norvegicus	152-155
29294454-10	2018	To conclude, the results have clearly shown that capsaicin performs a very important defensive role during breast carcinogenesis and has the ability to act as a chemo-suppressive factor against NMU effects.	Capsaicin	49-58	neuromedin U	Rattus norvegicus	194-197
29275446-1	2018	BACKGROUND: Visceral pain is initiated by activation of primary afferent neurons among which the capsaicin-sensitive (TRPV1-positive) neurons play an important role.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	118-123
29247491-4	2018	We found that the lipophilic capsaicin, mustard oil and menthol effectively get access to the nerve endings below the multilayered squamous epithelium, while cigarette smoke and its gaseous phase were weakly effective releasing CGRP.	Capsaicin	29-38	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	228-232
29132924-2	2018	Capsaicin, a component of chili pepper, which can stimulate actin remodeling via capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) and anti-inflammatory effects via PPARgamma (peroxisome proliferator-activated receptor-gamma) and LXRalpha (liver X receptor alpha), is a potential candidate to control chlamydial growth in host cells.	Capsaicin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	183-192
29132924-2	2018	Capsaicin, a component of chili pepper, which can stimulate actin remodeling via capsaicin receptor TRPV1 (transient receptor potential vanilloid 1) and anti-inflammatory effects via PPARgamma (peroxisome proliferator-activated receptor-gamma) and LXRalpha (liver X receptor alpha), is a potential candidate to control chlamydial growth in host cells.	Capsaicin	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	248-256
29339762-7	2018	Capsaicin treatment increased the expression of sXbp1 and Chop in brown preadipocytes and did not enhance lipid accumulation or Ucp1 expression in Xbp1 knockdown cells.	Capsaicin	0-9	DNA damage inducible transcript 3	Homo sapiens	58-62
29273526-9	2018	While the partly capsaicin-insensitive rabbit (o) TRPV1 fails to respond to AM404, AM404-sensitivity is restored by insertion of the capsaicin binding-domain of rat TRPV1 into oTRPV1.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	165-170
29273526-9	2018	While the partly capsaicin-insensitive rabbit (o) TRPV1 fails to respond to AM404, AM404-sensitivity is restored by insertion of the capsaicin binding-domain of rat TRPV1 into oTRPV1.	Capsaicin	133-142	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	165-170
29273526-11	2018	SIGNIFICANCE: AM404 gates TRPV1 by interacting with the vanilloid-binding site, and TRPV1 is the main receptor for AM404 in DRG neurons.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-31
29185571-0	2018	Capsaicin inhibits the metastasis of human papillary thyroid carcinoma BCPAP cells through the modulation of the TRPV1 channel.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-118
29185571-1	2018	Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-71
29185571-1	2018	Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
29185571-1	2018	Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	26-71
29185571-1	2018	Capsaicin (CAP), a potent transient receptor potential vanilloid type 1 (TRPV1) agonist, is a major ingredient of red pepper.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
29185571-4	2018	TRPV1, which can be activated by capsaicin, plays a key role in many biological and physiological processes.	Capsaicin	33-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
29185571-8	2018	The activation of TRPV1 by capsaicin (25-100 muM) significantly suppressed the migration and invasion of BCPAP cells as well as their adhesion.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
29185571-8	2018	The activation of TRPV1 by capsaicin (25-100 muM) significantly suppressed the migration and invasion of BCPAP cells as well as their adhesion.	Capsaicin	27-36	latexin	Homo sapiens	45-48
29185571-9	2018	The protein levels of Snail1 and Twist1, two critical EMT transcription factors (EMT-TFs), dramatically decreased in a dose-dependent manner after capsaicin treatment, accompanied by the up-regulation of downstream protein E-cadherin.	Capsaicin	147-156	snail family transcriptional repressor 1	Homo sapiens	22-28
29185571-9	2018	The protein levels of Snail1 and Twist1, two critical EMT transcription factors (EMT-TFs), dramatically decreased in a dose-dependent manner after capsaicin treatment, accompanied by the up-regulation of downstream protein E-cadherin.	Capsaicin	147-156	twist family bHLH transcription factor 1	Homo sapiens	33-39
29185571-9	2018	The protein levels of Snail1 and Twist1, two critical EMT transcription factors (EMT-TFs), dramatically decreased in a dose-dependent manner after capsaicin treatment, accompanied by the up-regulation of downstream protein E-cadherin.	Capsaicin	147-156	cadherin 1	Homo sapiens	223-233
29185571-10	2018	Subsequently, the activation of TRPV1 by capsaicin also caused significant inhibition of the expression of MMP-2 and MMP-9.	Capsaicin	41-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
29185571-10	2018	Subsequently, the activation of TRPV1 by capsaicin also caused significant inhibition of the expression of MMP-2 and MMP-9.	Capsaicin	41-50	matrix metallopeptidase 2	Homo sapiens	107-112
29185571-10	2018	Subsequently, the activation of TRPV1 by capsaicin also caused significant inhibition of the expression of MMP-2 and MMP-9.	Capsaicin	41-50	matrix metallopeptidase 9	Homo sapiens	117-122
29185571-11	2018	Moreover, the inhibitory effects of capsaicin on the metastasis of BCPAP cells were abrogated by the pre-treatment of a specific TRPV1 antagonist (capsazepin).	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	129-134
29185571-12	2018	Our results suggest that the activation of TRPV1 by capsaicin is associated with the metastatic inhibition of papillary thyroid cancer BCPAP cells, indicating that targeting of TRPV1 functions remains a feasible strategy for cancer treatment.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
29185571-12	2018	Our results suggest that the activation of TRPV1 by capsaicin is associated with the metastatic inhibition of papillary thyroid cancer BCPAP cells, indicating that targeting of TRPV1 functions remains a feasible strategy for cancer treatment.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	177-182
29339762-1	2018	We previously showed that brown (pre)adipocytes express Trpv1, a capsaicin receptor, and that capsaicin stimulates differentiation of brown preadipocytes in the late stages of brown adipogenesis.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
29339762-3	2018	Treatment with capsaicin (100 muM) during brown adipogenesis enhanced lipid accumulation and the expression of Ucp1, a gene selectively expressed in brown adipocytes.	Capsaicin	15-24	uncoupling protein 1	Homo sapiens	111-115
28762564-1	2018	AIMS: This study was initiated to investigate the involvement of neutrophil leukocyte activation in neurogenic inflammation, a process also involved in human urinary pathologies, elicited in the rat urinary bladder by the local administration of capsaicin, the archetypal TRPV1 agonist.	Capsaicin	246-255	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	272-277
28762564-7	2018	RESULTS: Capsaicin induced rapid increases in leukocyte rolling and adhesion and increased the expression of E-selectin and ICAM-1 in the postcapillary venules.	Capsaicin	9-18	selectin E	Rattus norvegicus	109-119
28762564-7	2018	RESULTS: Capsaicin induced rapid increases in leukocyte rolling and adhesion and increased the expression of E-selectin and ICAM-1 in the postcapillary venules.	Capsaicin	9-18	intercellular adhesion molecule 1	Rattus norvegicus	124-130
28762564-10	2018	CONCLUSIONS: Topical application of capsaicin induces early neurogenically mediated cellular microcirculatory inflammatory reactions via the activation of the TRPV1 receptor and the release of CGRP and SP from sensory nerves in the bladder.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	159-164
28762564-10	2018	CONCLUSIONS: Topical application of capsaicin induces early neurogenically mediated cellular microcirculatory inflammatory reactions via the activation of the TRPV1 receptor and the release of CGRP and SP from sensory nerves in the bladder.	Capsaicin	36-45	calcitonin-related polypeptide alpha	Rattus norvegicus	193-197
28762564-11	2018	Co-administration of SP and CGRP receptor antagonists may ameliorate microcirculatory inflammatory changes elicited by capsaicin in the urinary bladder.	Capsaicin	119-128	calcitonin-related polypeptide alpha	Rattus norvegicus	28-32
29338036-0	2018	Static magnetic field enhances the anticancer efficacy of capsaicin on HepG2 cells via capsaicin receptor TRPV1.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	106-111
29338036-6	2018	We found that the synergistic effect could be due to that SMF increased the binding efficiency of capsaicin for the TRPV1 channel.	Capsaicin	98-107	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-121
29339762-7	2018	Capsaicin treatment increased the expression of sXbp1 and Chop in brown preadipocytes and did not enhance lipid accumulation or Ucp1 expression in Xbp1 knockdown cells.	Capsaicin	0-9	X-box binding protein 1	Homo sapiens	49-53
29335450-2	2018	Although activation of TRPV1 cation channels by capsaicin may reduce lipid storage and the formation of atherosclerotic lesions, a clinical use for capsaicin has been limited by its chronic toxicity.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
29175072-0	2018	Capsaicin prevents mitochondrial damage, protects cardiomyocytes subjected to anoxia/reoxygenation injury mediated by 14-3-3eta/Bcl-2.	Capsaicin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	128-133
29317663-8	2018	TRPV1 modulates P2X mediated afferent responses and provides a mechanistic basis for the decrease in sensory symptoms observed following resiniferatoxin and capsaicin treatment for lower urinary tract symptoms.	Capsaicin	157-166	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
29279388-1	2018	The TRPV1 channel is a sensitive detector of pain-producing stimuli, including noxious heat, acid, inflammatory mediators, and vanilloid compounds.	Capsaicin	127-136	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
30306512-4	2018	In that study, we induced ANO1 currents by application of capsaicin to small DRG neurons and showed that ANO1-dependent depolarization following TRPV1 activation could evoke more action potentials.	Capsaicin	58-67	anoctamin 1, calcium activated chloride channel	Mus musculus	26-30
29304162-2	2018	Capsaicin is the most commonly used vanilloid to stimulate TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
29304162-2	2018	Capsaicin is the most commonly used vanilloid to stimulate TRPV1.	Capsaicin	36-45	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
29191767-5	2018	Substantial views on the capsaicin receptor Transient Receptor Potential Vanilloid V1 (TRPV1), its presence, significance and capsaicin induced mediations have been presented.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-85
29191767-5	2018	Substantial views on the capsaicin receptor Transient Receptor Potential Vanilloid V1 (TRPV1), its presence, significance and capsaicin induced mediations have been presented.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
29191767-7	2018	In this regard, TRPV1 antagonists (especially the competitive antagonist Capsazepine) have been indicated as potential candidates in mitigating or alleviating capsaicin elicited ocular responses.	Capsaicin	159-168	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-21
29191767-8	2018	The review overall is a comprehensive perspective of the ocular inflammatory and pharmacological responses generated on exposure to capsaicin and concludes suggesting a possible regulatory framework for relief from the same presumably by the employment of specialized and target specific TRPV1 antagonists.	Capsaicin	132-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	288-293
30306512-4	2018	In that study, we induced ANO1 currents by application of capsaicin to small DRG neurons and showed that ANO1-dependent depolarization following TRPV1 activation could evoke more action potentials.	Capsaicin	58-67	anoctamin 1, calcium activated chloride channel	Mus musculus	105-109
30306512-4	2018	In that study, we induced ANO1 currents by application of capsaicin to small DRG neurons and showed that ANO1-dependent depolarization following TRPV1 activation could evoke more action potentials.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	145-150
30306512-5	2018	Furthermore, capsaicin-evoked pain-related behaviors in mice were strongly inhibited by a selective ANO1 blocker.	Capsaicin	13-22	anoctamin 1, calcium activated chloride channel	Mus musculus	100-104
30531157-1	2018	Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive cation channel that is activated by heat, protons and chemical ligands such as capsaicin.	Capsaicin	145-154	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
29239736-6	2018	We applied these findings to develop BODIPY-caged capsaicin, which is well localized to low-polarity intracellular compartments, as a tool to stimulate TRPV1 in live cells in response to blue-green light.	Capsaicin	50-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	152-157
30531157-1	2018	Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive cation channel that is activated by heat, protons and chemical ligands such as capsaicin.	Capsaicin	145-154	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
30531157-6	2018	Here, we showed that intragastric administration of AMG517, a nonselective antagonist of TRPV1 (for heat, protons and capsaicin), enhanced energy metabolism as much as did intraperitoneal administration.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	89-94
30531157-8	2018	However, the administration of JYL1421, a TRPV1 antagonist that very strongly inhibits TRPV1 activated by capsaicin, did not change energy metabolism.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
30531157-8	2018	However, the administration of JYL1421, a TRPV1 antagonist that very strongly inhibits TRPV1 activated by capsaicin, did not change energy metabolism.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	87-92
30209980-0	2018	Effect of single-nucleotide polymorphisms in TRPV1 on burning pain and capsaicin sensitivity in Japanese adults.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-50
29094347-1	2018	OBJECTIVE: The current study examined pain and neurogenic inflammation responses to topical capsaicin during the interictal period (between headache) and their relationship with plasma oxytocin in individuals with migraine.	Capsaicin	92-101	oxytocin/neurophysin I prepropeptide	Homo sapiens	185-193
29094347-11	2018	The oxytocin levels were elevated in migraineurs and accounted for 18% of the group difference in capsaicin-induced pain unpleasantness.	Capsaicin	98-107	oxytocin/neurophysin I prepropeptide	Homo sapiens	4-12
30078015-4	2018	METHODS: TRPV1 was activated or down-regulated by subcutaneous injection of a low (1mg/kg) or high (100mg/kg) dose of capsaicin, respectively, 3 hours before ischemia.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-14
29379817-3	2018	However, involvement of transient receptor potential vanilloid subtype 1 (TRPV1) receptor, which is activated by marijuana, capsaicin, and heat, could fill gaps in existing models, including the enigmatic role of hot water bathing.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
29379817-4	2018	We propose that chronic cannabis use decreases TRPV1 signaling and alters gastric motility, and we report the case of a CHS patient whose symptoms improved after topical capsaicin.	Capsaicin	170-179	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
28730896-22	2018	"Sensocrine" antiemetic effects: Transient receptor potential vanilloid 1 activation by heat or capsaicin results in modulation of tachykinins, somatostatin, pituitary adenylate-cyclase activating polypeptide, and calcitonin gene-related peptide as well as histaminergic, cholinergic, and serotonergic transmission.	Capsaicin	96-105	adenylate cyclase activating polypeptide 1	Homo sapiens	158-208
30209980-1	2018	Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is expressed in the sensory neurons and responds to various noxious stimuli including heat and capsaicin.	Capsaicin	182-191	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
30209980-1	2018	Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel that is expressed in the sensory neurons and responds to various noxious stimuli including heat and capsaicin.	Capsaicin	182-191	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
30209980-2	2018	The molecular properties of TRPV1 have been clearly examined; however, there are obvious individual differences in human sensitivity to thermal stimuli and capsaicin.	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
30209980-3	2018	Here, we examined the possibility that different genome sequence of human TRPV1 caused the different sensitivity to heat or capsaicin.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
29576710-10	2018	Conclusion: Our data implied that capsaicin could reverse the inhibitory effect of licochalcone A/beta-arbutin on tyrosinase expression in B16 mouse melanoma cells.	Capsaicin	34-43	tyrosinase	Mus musculus	114-124
29576710-14	2018	However, licochalcone A/beta-arbutin combined with 50 mumol/L capsaicin enhanced the expression of tyrosinase in these cells and further increased melanin content.	Capsaicin	62-71	tyrosinase	Mus musculus	99-109
29576710-0	2018	Capsaicin reverses the inhibitory effect of licochalcone A/beta-Arbutin on tyrosinase expression in b16 mouse melanoma cells.	Capsaicin	0-9	tyrosinase	Mus musculus	75-85
29576710-15	2018	Our research implied that capsaicin could reverse the inhibitory effect of licochalcone A/beta-arbutin on tyrosinase expression in B16 mouse melanoma cells.	Capsaicin	26-35	tyrosinase	Mus musculus	106-116
29576710-9	2018	However, licochalcone A/beta-arbutin combined with 50 mumol/L capsaicin enhanced the expression of tyrosinase in these cells and further increased melanin content.	Capsaicin	62-71	tyrosinase	Mus musculus	99-109
30068839-2	2018	The site of action for capsaicin has been discovered as transient receptor potential vanilloid receptor subtype 1 (TRPV1) that resides on the membranes of pain- and heat-sensing primary afferent nerves.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	115-120
29059001-6	2018	There was no evidence either that, at fixed temperature, radiofrequency exposure altered the maximal efficacy of the agonist Capsaicin to activate TRPV1.	Capsaicin	125-134	transient receptor potential cation channel subfamily V member 1	Homo sapiens	147-152
30068839-5	2018	Therefore, capsaicin stimulates TRPV1 not only on the tongue but also in the gut.	Capsaicin	11-20	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	32-37
29206105-5	2017	Photon counts and optical fluctuations from coumarin encoded within TRPV1 tetramers correlates with channel activation by capsaicin, providing an optical marker of conformational dynamics at the selectivity filter.	Capsaicin	122-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-73
29246976-4	2018	Capsaicin reduced the magnitude of LA-LTP in slices derived from wild-type mice as previously described, whereas this capsaicin-induced suppression was absent in GluA1-deficient mice.	Capsaicin	118-127	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	162-167
29246976-6	2018	Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	66-71
29246976-6	2018	Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.	Capsaicin	23-32	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	81-86
29246976-6	2018	Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.	Capsaicin	23-32	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	98-104
29246976-6	2018	Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.	Capsaicin	23-32	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	98-103
29246976-6	2018	Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.	Capsaicin	23-32	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	208-213
29246976-6	2018	Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.	Capsaicin	113-122	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	156-161
29246976-6	2018	Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit.	Capsaicin	113-122	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	208-213
29259542-0	2017	Capsaicin Enhances Glutamatergic Synaptic Transmission to Neonatal Rat Hypoglossal Motor Neurons via a TRPV1-Independent Mechanism.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	103-108
29259542-1	2017	We investigated whether capsaicin modulated synaptic transmission to hypoglossal motor neurons (HMNs) by acting on transient receptor potential vanilloid type 1 (TRPV1) receptors.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	115-160
29259542-1	2017	We investigated whether capsaicin modulated synaptic transmission to hypoglossal motor neurons (HMNs) by acting on transient receptor potential vanilloid type 1 (TRPV1) receptors.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	162-167
29259542-6	2017	The effect of capsaicin on excitatory synaptic transmission remained unchanged in the presence of the TRPV1 antagonists, capsazepine or SB366791, suggesting that capsaicin acts to modulate EPSCs via a mechanism which does not require TRPV1 activation.	Capsaicin	162-171	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	102-107
29259542-6	2017	The effect of capsaicin on excitatory synaptic transmission remained unchanged in the presence of the TRPV1 antagonists, capsazepine or SB366791, suggesting that capsaicin acts to modulate EPSCs via a mechanism which does not require TRPV1 activation.	Capsaicin	162-171	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	234-239
29246976-0	2018	Glutamate receptor GluA1 subunit is implicated in capsaicin induced modulation of amygdala LTP but not LTD. Capsaicin has been shown to modulate synaptic plasticity in various brain regions including the amygdala.	Capsaicin	50-59	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	19-24
29246976-0	2018	Glutamate receptor GluA1 subunit is implicated in capsaicin induced modulation of amygdala LTP but not LTD. Capsaicin has been shown to modulate synaptic plasticity in various brain regions including the amygdala.	Capsaicin	108-117	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	19-24
29246976-1	2018	Whereas in the lateral amygdala the modulatory effect of capsaicin on long-term potentiation (LA-LTP) is mediated by TRPV1 channels, we have recently shown that capsaicin-induced enhancement of long term depression (LA-LTD) is mediated by TRPM1 receptors.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	117-122
29246976-1	2018	Whereas in the lateral amygdala the modulatory effect of capsaicin on long-term potentiation (LA-LTP) is mediated by TRPV1 channels, we have recently shown that capsaicin-induced enhancement of long term depression (LA-LTD) is mediated by TRPM1 receptors.	Capsaicin	161-170	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	117-122
29246976-1	2018	Whereas in the lateral amygdala the modulatory effect of capsaicin on long-term potentiation (LA-LTP) is mediated by TRPV1 channels, we have recently shown that capsaicin-induced enhancement of long term depression (LA-LTD) is mediated by TRPM1 receptors.	Capsaicin	161-170	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	239-244
29129206-5	2017	While activation of TRPV1 by the vanilloids capsaicin, resiniferatoxin and anandamide results in calcium-dependent cell death, activation by protons and the oxidant chloramine-T failed to reduce cell viability.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
28945920-7	2017	The TRPV1-specific agonists capsaicin and resiniferatoxin did not affect the intracellular Ca2+ concentration.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
29129206-2	2017	In sensory neurons, vanilloids like capsaicin induce neurotoxicity by activating TRPV1.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
27919018-7	2017	Immunohistochemical staining for phospho-extracellular signal-related kinase (pERK) in the trigeminal ganglion (TG) containing first and second divisions of the trigeminal nerve and the trigeminocervical complex (TCC) revealed that pERK expression was significantly increased in the CCI-ION + Capsaicin group compared with the other groups.	Capsaicin	293-302	eukaryotic translation initiation factor 2 alpha kinase 3	Homo sapiens	33-76
29122973-5	2017	The use of topical capsaicin cream to treat CHS has been well described in the adult literature.	Capsaicin	19-28	lysosomal trafficking regulator	Homo sapiens	44-47
29035821-5	2017	The activation of TRPV1 receptors is achieved by administering capsaicin (CAP), the main TRPV1 agonist exerting a widely reported proepileptic effects.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-23
29035821-5	2017	The activation of TRPV1 receptors is achieved by administering capsaicin (CAP), the main TRPV1 agonist exerting a widely reported proepileptic effects.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	89-94
29198921-8	2017	It has been recognized that capsaicinoids are the most potential agonists of capsaicin receptor (TRPV1).	Capsaicin	28-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-95
29198921-8	2017	It has been recognized that capsaicinoids are the most potential agonists of capsaicin receptor (TRPV1).	Capsaicin	28-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
29198921-11	2017	Better understanding of the established TRPV1 receptor mechanism as well as exploring other possible receptor mechanism may publicize other new clinical efficacies of capsaicin.	Capsaicin	167-176	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
28861768-0	2017	Capsaicin Protects Against Oxidative Insults and Alleviates Behavioral Deficits in Rats with 6-OHDA-Induced Parkinson"s Disease via Activation of TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-151
28861768-6	2017	Both the expression of tyrosine hydroxylase and TRPV1 were increased in the striatal and substantia nigra areas of 6-OHDA induced rats after the treatment of capsaicin by the semi-quantitative analysis of Western Blot.	Capsaicin	158-167	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	48-53
29122973-9	2017	These are the first reported cases in which capsaicin was successfully used to treat CHS in pediatric patients.	Capsaicin	44-53	lysosomal trafficking regulator	Homo sapiens	85-88
29089436-4	2017	MET-1 reduced the excitability of DRG neurons by significantly increasing rheobase, decreasing responses to capsaicin (2 mum) and reducing action potential discharge from colonic afferent nerves.	Capsaicin	108-117	granzyme M	Homo sapiens	0-5
29128793-0	2017	Phytochemicals genistein and capsaicin modulate Kv2.1 channel gating.	Capsaicin	29-38	potassium voltage-gated channel subfamily B member 1	Homo sapiens	48-53
29128793-3	2017	The present study investigates the effects of the phytochemicals genistein and capsaicin on voltage-gated potassium Kv2.1 channels.	Capsaicin	79-88	potassium voltage-gated channel subfamily B member 1	Homo sapiens	116-121
29128793-4	2017	METHODS: The whole-cell patch clamp technique was used to explore the regulation of Kv2.1 channels expressed in HEK293 cells by genistein and capsaicin.	Capsaicin	142-151	potassium voltage-gated channel subfamily B member 1	Homo sapiens	84-89
29128793-6	2017	Moreover, genistein and capsaicin inhibited Kv2.1 currents in a concentration dependent manner.	Capsaicin	24-33	potassium voltage-gated channel subfamily B member 1	Homo sapiens	44-49
29128793-7	2017	CONCLUSION: This study effectively demonstrated the inhibitory effects of genistein and capsaicin on Kv2.1 channels.	Capsaicin	88-97	potassium voltage-gated channel subfamily B member 1	Homo sapiens	101-106
31457378-0	2017	Ultrasensitive Detection of Capsaicin in Oil for Fast Identification of Illegal Cooking Oil by SERRS.	Capsaicin	28-37	seryl-tRNA synthetase 2, mitochondrial	Homo sapiens	95-100
27832523-13	2017	The TRPV1 is also activated by mitochondrial oxidative stress and capsaicin, and it is blocked by capsazepine (CPZ).	Capsaicin	66-75	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
28587842-5	2017	Accompanying these inflammatory reactions, the sensitivity of vagal pulmonary C-fibers and silent rapidly adapting receptors to capsaicin, a selective agonist of transient receptor potential vanilloid type 1 receptor, was markedly elevated after the TNFalpha treatment.	Capsaicin	128-137	tumor necrosis factor	Mus musculus	250-258
28587842-6	2017	A distinct increase in the sensitivity to capsaicin induced by TNFalpha was also observed in isolated pulmonary sensory neurons, suggesting that the sensitizing effect is mediated primarily through a direct action of TNFalpha on these neurons.	Capsaicin	42-51	tumor necrosis factor	Mus musculus	63-71
28587842-6	2017	A distinct increase in the sensitivity to capsaicin induced by TNFalpha was also observed in isolated pulmonary sensory neurons, suggesting that the sensitizing effect is mediated primarily through a direct action of TNFalpha on these neurons.	Capsaicin	42-51	tumor necrosis factor	Mus musculus	217-225
29117570-6	2017	In TRPV1 knockout mice, DRG neurons exhibit reduced oxytocin sensitivity relative to controls, and oxytocin injections significantly attenuate capsaicin-induced nociception in in vivo experiments.	Capsaicin	143-152	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	3-8
29176651-3	2017	We demonstrate that miR-21-5p is released in the exosomal fraction of cultured DRG following capsaicin activation of TRPV1 receptors.	Capsaicin	93-102	microRNA 215	Mus musculus	20-28
29176651-3	2017	We demonstrate that miR-21-5p is released in the exosomal fraction of cultured DRG following capsaicin activation of TRPV1 receptors.	Capsaicin	93-102	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	117-122
29176651-4	2017	Pure sensory neuron-derived exosomes released by capsaicin are readily phagocytosed by macrophages in which an increase in miR-21-5p expression promotes a pro-inflammatory phenotype.	Capsaicin	49-58	microRNA 215	Mus musculus	123-131
28970017-2	2017	This study was aimed to investigate the effects of microinjection of muscarinic and nicotinic acetylcholine receptor antagonists and agonists into the ventrolateral orbital cortex (VLOC) on capsaicin-induced orofacial nociception and subsequent hyperalgesia.	Capsaicin	190-199	cholinergic receptor nicotinic alpha 2 subunit	Rattus norvegicus	84-116
28650204-1	2017	RATIONALE: Heightened cough responses to inhaled capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-102
28650204-1	2017	RATIONALE: Heightened cough responses to inhaled capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, are characteristic of patients with chronic cough.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-109
29117570-6	2017	In TRPV1 knockout mice, DRG neurons exhibit reduced oxytocin sensitivity relative to controls, and oxytocin injections significantly attenuate capsaicin-induced nociception in in vivo experiments.	Capsaicin	143-152	oxytocin	Mus musculus	99-107
27730727-1	2017	Transient receptor potential vanilloid type 1 (TRPV1), the archetypal member of the vanilloid TRP family, was initially identified as the receptor for capsaicin, the pungent ingredient in hot chili peppers.	Capsaicin	151-160	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	47-52
31966488-1	2017	Transient receptor potential vanilloid 1 (TRPV1), the receptor of capsaicin, is a nonselective cation channel that is highly permeable to Ca2+.	Capsaicin	66-75	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
29180855-10	2017	Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-86
29180855-10	2017	Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
29180855-10	2017	Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	252-257
29180855-10	2017	Conclusion: As capsaicin is an agonist of the transient receptor potential vanilloid 1 (TRPV1), these findings suggest that improvement of the swallowing function, especially glottal closure and cough reflexes, in elderly dysphagic patients was due to TRPV1-mediated aural stimulation of vagal Arnold"s nerve with capsaicin, but not with a nonspecific mechanical stimulation with a cotton swab.	Capsaicin	314-323	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-86
29180887-0	2017	Ingested capsaicinoids can prevent low-fat-high-carbohydrate diet and high-fat diet-induced obesity by regulating the NADPH oxidase and Nrf2 pathways.	Capsaicin	9-22	NFE2 like bZIP transcription factor 2	Rattus norvegicus	136-140
31966488-1	2017	Transient receptor potential vanilloid 1 (TRPV1), the receptor of capsaicin, is a nonselective cation channel that is highly permeable to Ca2+.	Capsaicin	66-75	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
28687197-1	2017	Recently, we reported that capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, protected against excitotoxicity induced by intravitreal N-methyl-D-aspartic acid (NMDA) in the rats in vivo.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	40-84
28867580-10	2017	Capsaicin, the vanilloid receptor subtype1 (TRPV1) agonist, potentiated the vasoconstriction due to heating.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	44-49
29048662-8	2017	Moreover, our results revealed that the anticancer effects induced by capsaicin on OS cell lines involved multiple MAPK signaling pathways as indicated by inactivation of the ERK1/2 and p38 pathways and activation of the JNK pathway.	Capsaicin	70-79	mitogen-activated protein kinase 3	Homo sapiens	115-119
29048662-8	2017	Moreover, our results revealed that the anticancer effects induced by capsaicin on OS cell lines involved multiple MAPK signaling pathways as indicated by inactivation of the ERK1/2 and p38 pathways and activation of the JNK pathway.	Capsaicin	70-79	mitogen-activated protein kinase 3	Homo sapiens	175-181
29048662-8	2017	Moreover, our results revealed that the anticancer effects induced by capsaicin on OS cell lines involved multiple MAPK signaling pathways as indicated by inactivation of the ERK1/2 and p38 pathways and activation of the JNK pathway.	Capsaicin	70-79	mitogen-activated protein kinase 1	Homo sapiens	186-189
29048662-8	2017	Moreover, our results revealed that the anticancer effects induced by capsaicin on OS cell lines involved multiple MAPK signaling pathways as indicated by inactivation of the ERK1/2 and p38 pathways and activation of the JNK pathway.	Capsaicin	70-79	mitogen-activated protein kinase 8	Homo sapiens	221-224
28892388-2	2017	While radiolabeled resiniferatoxin (RTX) has provided a powerful tool for characterization of vanilloid binding to TRPV1, TRPV1 shows 20-fold weaker binding to the human TRPV1 than to the rodent TRPV1.	Capsaicin	94-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	115-120
28649695-8	2017	A few aromatase neurons express Fos after cheek injection of capsaicin, formalin, or chloroquine.	Capsaicin	61-70	cytochrome P450 family 19 subfamily A member 1	Homo sapiens	6-15
28649695-8	2017	A few aromatase neurons express Fos after cheek injection of capsaicin, formalin, or chloroquine.	Capsaicin	61-70	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	32-35
28687197-1	2017	Recently, we reported that capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, protected against excitotoxicity induced by intravitreal N-methyl-D-aspartic acid (NMDA) in the rats in vivo.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	86-91
29046638-6	2017	While intra-dPAG AEA did not change acute pain, local injections of capsaicin or WIN induced a marked TRPV1- and CB1-dependent antinociceptive effect, respectively.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	102-107
29046638-6	2017	While intra-dPAG AEA did not change acute pain, local injections of capsaicin or WIN induced a marked TRPV1- and CB1-dependent antinociceptive effect, respectively.	Capsaicin	68-77	cannabinoid receptor 1 (brain)	Mus musculus	113-116
27687880-4	2017	Methods CGRP-dependent increases in DBF were assessed using laser Doppler perfusion imaging after topical application of 300 or 1000 microg capsaicin on the forearm of healthy subjects and migraine patients.	Capsaicin	140-149	calcitonin related polypeptide alpha	Homo sapiens	8-12
28877968-0	2017	Action Potential Broadening in Capsaicin-Sensitive DRG Neurons from Frequency-Dependent Reduction of Kv3 Current.	Capsaicin	31-40	potassium voltage-gated channel subfamily A member 3	Rattus norvegicus	101-104
27687880-8	2017	Conclusions An increased capsaicin-induced, CGRP-mediated DBF response was observed during menstruation in healthy women, but in female migraine patients this increased response was not affected by the menstrual cycle.	Capsaicin	25-34	calcitonin related polypeptide alpha	Homo sapiens	44-48
28957441-4	2017	Notably, functionally important genes (e.g. the mechanosensory channel Piezo2 and the capsaicin gated ion channel Trpv1) segregate into multiple clusters and often are expressed in subsets of cells within a cluster.	Capsaicin	86-95	piezo-type mechanosensitive ion channel component 2	Mus musculus	71-77
28977586-8	2017	Long pretreatment (14 hours) with E2 induced a significant increase in TRPV1 receptor messenger RNA expression and abolished the capsaicin-induced TRPV1 receptor desensitization in primary sensory neurons.	Capsaicin	129-138	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	147-152
28957441-4	2017	Notably, functionally important genes (e.g. the mechanosensory channel Piezo2 and the capsaicin gated ion channel Trpv1) segregate into multiple clusters and often are expressed in subsets of cells within a cluster.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	114-119
29152112-0	2017	Capsaicin exerts synergistic antitumor effect with sorafenib in hepatocellular carcinoma cells through AMPK activation.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	103-107
29152112-4	2017	In the combination treatment using capsaicin and sorafenib, increased apoptosis, followed by the activation of caspase-9 and PARP, was observed.	Capsaicin	35-44	caspase 9	Homo sapiens	111-120
29152112-4	2017	In the combination treatment using capsaicin and sorafenib, increased apoptosis, followed by the activation of caspase-9 and PARP, was observed.	Capsaicin	35-44	collagen type XI alpha 2 chain	Homo sapiens	125-129
29152112-5	2017	In addition, the present study demonstrated that sorafenib treatment induces activation of Akt, probably as a mechanism of resistance, whereas capsaicin inhibits Akt providing a possible pathway whereby capsaicin sensitizes to sorafenib in HCC cells.	Capsaicin	143-152	AKT serine/threonine kinase 1	Homo sapiens	162-165
29152112-6	2017	Moreover, capsaicin singly and the combination of capsaicin and sorafenib induce AMPK activation and Acetyl CoA carboxylase phosphorylation in HCC cells.	Capsaicin	10-19	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	81-85
29152112-6	2017	Moreover, capsaicin singly and the combination of capsaicin and sorafenib induce AMPK activation and Acetyl CoA carboxylase phosphorylation in HCC cells.	Capsaicin	50-59	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	81-85
29152112-7	2017	Knocking down of AMPK by selective siRNA abrogates capsaicin-induced Akt inhibition, suggesting the involvement of AMPK in the antiproliferative effect.	Capsaicin	51-60	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	17-21
29152112-7	2017	Knocking down of AMPK by selective siRNA abrogates capsaicin-induced Akt inhibition, suggesting the involvement of AMPK in the antiproliferative effect.	Capsaicin	51-60	AKT serine/threonine kinase 1	Homo sapiens	69-72
29152112-7	2017	Knocking down of AMPK by selective siRNA abrogates capsaicin-induced Akt inhibition, suggesting the involvement of AMPK in the antiproliferative effect.	Capsaicin	51-60	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	115-119
28838698-4	2017	Both compounds also proved to be very potent antagonists for rTRPV1, blocking in vivo the hypothermic action of capsaicin, consistent with their in vitro mechanism.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-67
28494183-3	2017	Topical capsaicin is a proposed treatment for CHS; it binds TRPV1 with high specificity, impairing substance P signaling in the area postrema and nucleus tractus solitarius via overstimulation of TRPV1.	Capsaicin	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-65
28687195-8	2017	However, beta2-MG-induced scratching was attenuated in mice desensitized by repeated application of capsaicin and also by a selective transient receptor potential vanilloid 1 (TRPV1) antagonist (BCTC).	Capsaicin	100-109	hemoglobin, beta adult minor chain	Mus musculus	9-14
28622417-6	2017	Pre-exposure to isopetasin produced marked desensitization of allyl isothiocyanate (AITC, TRPA1 channel agonist)- or capsaicin (TRPV1 channel agonist)-evoked currents in rat TG neurons, contractions of rat or mouse bladder and CGRP release from mouse central terminals of primary sensory neurons.	Capsaicin	117-126	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	128-133
28494183-3	2017	Topical capsaicin is a proposed treatment for CHS; it binds TRPV1 with high specificity, impairing substance P signaling in the area postrema and nucleus tractus solitarius via overstimulation of TRPV1.	Capsaicin	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	196-201
28783046-6	2017	Moreover, EREG application potentiated capsaicin-induced calcium influx in a subset of sensory neurons.	Capsaicin	39-48	epiregulin	Mus musculus	10-14
28444833-4	2017	METHOD: Capsaicin-sensitive neurones were desensitized by the capsaicin analogue resiniferatoxin (RTX) in CD1 mice.	Capsaicin	8-17	CD1 antigen complex	Mus musculus	106-109
28444833-4	2017	METHOD: Capsaicin-sensitive neurones were desensitized by the capsaicin analogue resiniferatoxin (RTX) in CD1 mice.	Capsaicin	62-71	CD1 antigen complex	Mus musculus	106-109
28479337-8	2017	Trpv1 knock-out abolished the inhibitory effect of capsaicin on glutamate-induced calcium influx and subsequent neuronal death.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
28479337-9	2017	Reduced expression of GluN1 and GluN2B, subunits of NMDA receptor, was examined after capsaicin treatment in cortical neurons.	Capsaicin	86-95	glutamate ionotropic receptor NMDA type subunit 1	Rattus norvegicus	22-27
28479337-9	2017	Reduced expression of GluN1 and GluN2B, subunits of NMDA receptor, was examined after capsaicin treatment in cortical neurons.	Capsaicin	86-95	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	32-38
28479337-10	2017	In summary, our studies reveal that the neuroprotective effect of capsaicin in cortical neurons is TRPV1-dependent and down-regulation of the expression and function of NMDA receptors contributes to the protection afforded by capsaicin.	Capsaicin	66-75	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
28681979-5	2017	Thus, the vasodilatory role of TRPV1 channels, and their ligand capsaicin, could be a potential therapeutic target for improving vascular function.	Capsaicin	64-73	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
28656459-7	2017	Here, we first show that capsaicin-induced adrenaline secretion is completely impaired in TRPV1 knockout mice.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	90-95
28251657-8	2017	Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	89-134
28251657-8	2017	Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-141
28251657-8	2017	Capsaicin and unsaturated fatty acid PSO can activate and improve the mRNA expression of transient receptor potential vanilloid type-1 (TRPV1) and peroxisome proliferators-activated receptors (PPARalpha).	Capsaicin	0-9	peroxisome proliferator activated receptor alpha	Rattus norvegicus	193-202
28673718-10	2017	After intraplantar administration of capsaicin, LIM was able to significantly decrease time to lick.	Capsaicin	37-46	PDZ and LIM domain 5	Mus musculus	48-51
28890700-12	2017	Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-alpha, IL-1beta, and IL-6 levels as compared with the normal diet.	Capsaicin	27-36	glucagon	Mus musculus	103-108
29100335-7	2017	Furthermore, it was demonstrated that MDA MB231 and VEGF-A induced sensory neuronal sensitisation in response to capsaicin a TRPV1 agonist.	Capsaicin	113-122	vascular endothelial growth factor A	Homo sapiens	52-58
29100335-7	2017	Furthermore, it was demonstrated that MDA MB231 and VEGF-A induced sensory neuronal sensitisation in response to capsaicin a TRPV1 agonist.	Capsaicin	113-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	125-130
28890700-12	2017	Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-alpha, IL-1beta, and IL-6 levels as compared with the normal diet.	Capsaicin	27-36	ghrelin	Mus musculus	144-151
28890700-12	2017	Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-alpha, IL-1beta, and IL-6 levels as compared with the normal diet.	Capsaicin	27-36	tumor necrosis factor	Mus musculus	153-162
28890700-12	2017	Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-alpha, IL-1beta, and IL-6 levels as compared with the normal diet.	Capsaicin	27-36	interleukin 1 beta	Mus musculus	164-172
28890700-12	2017	Finally, the low- and high-capsaicin diets significantly increased the fecal butyrate and plasma total GLP-1 levels, but decreased plasma total ghrelin, TNF-alpha, IL-1beta, and IL-6 levels as compared with the normal diet.	Capsaicin	27-36	interleukin 6	Mus musculus	178-182
28817717-0	2017	Short Report: TRPV1-polymorphism 1911 A&gt;G alters capsaicin-induced sensory changes in healthy subjects.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
28831021-5	2017	However, only the two 11-hydroxy-epoxy-octadecenoates sensitized rat dorsal root ganglion neurons to release more calcitonin gene-related peptide (CGRP), which is involved in pain transmission, in response to low pH (which mimics an inflammatory state) or capsaicin (which activates ion channels involved in nociception).	Capsaicin	256-265	calcitonin-related polypeptide alpha	Rattus norvegicus	147-151
28817717-10	2017	CONCLUSION: Presence of homozygous variant TRPV1 genotype (GG) demonstrated less capsaicin-induced warm hypoesthesia in warm-detection and less capsaicin-induced heat pain sensitivity suggesting an altered channel function.	Capsaicin	81-90	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
28817717-10	2017	CONCLUSION: Presence of homozygous variant TRPV1 genotype (GG) demonstrated less capsaicin-induced warm hypoesthesia in warm-detection and less capsaicin-induced heat pain sensitivity suggesting an altered channel function.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
28798481-7	2017	Transient receptor potential vanilloid 1 (TRPV1) ion channel was expressed in hADSC, and the TRPV1 ligand capsaicin (5uM) stimulated proliferation, which could be abrogated by capsazepine.	Capsaicin	106-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
29088797-7	2017	Furthermore, Corin and 4930423020Rik were down-regulated in itch model group compared to capsaicin group.	Capsaicin	89-98	corin, serine peptidase	Mus musculus	13-18
28520395-1	2017	TRPV1 is a prominent signal integrator of the pain system, known to be activated by vanilloids, a family of endogenous and exogenous pain-evoking molecules, through the vanilloid-binding site (VBS).	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
28798481-7	2017	Transient receptor potential vanilloid 1 (TRPV1) ion channel was expressed in hADSC, and the TRPV1 ligand capsaicin (5uM) stimulated proliferation, which could be abrogated by capsazepine.	Capsaicin	106-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
28798481-7	2017	Transient receptor potential vanilloid 1 (TRPV1) ion channel was expressed in hADSC, and the TRPV1 ligand capsaicin (5uM) stimulated proliferation, which could be abrogated by capsazepine.	Capsaicin	106-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-98
28392320-7	2017	The geometric mean of capsaicin causing &gt;=5 coughs (C5) increased from 134 to 203 muM in non-smokers and from 117 to 287 muM in asthmatics after AMP, whereas it decreased from 203 to 165 muM and 125 to 88 muM, respectively after ATP.	Capsaicin	22-31	latexin	Homo sapiens	85-88
28389389-1	2017	BACKGROUND: The therapeutic action of capsaicin treatment in patients with idiopathic rhinitis (IR) is based on ablation of the transient receptor potential cation channel subfamily V, receptor 1 (TRPV1)-substance P nociceptive signaling pathway.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	197-202
28522561-3	2017	First, a brief pretreatment with a low dose of TNFalpha (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Delta = 247%) immediately following the TNFalpha pretreatment, which gradually declined toward control and then increased again reaching another peak (Delta = 384%) after 60-90 min.	Capsaicin	235-244	tumor necrosis factor	Rattus norvegicus	47-55
28522561-3	2017	First, a brief pretreatment with a low dose of TNFalpha (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Delta = 247%) immediately following the TNFalpha pretreatment, which gradually declined toward control and then increased again reaching another peak (Delta = 384%) after 60-90 min.	Capsaicin	235-244	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-146
28522561-3	2017	First, a brief pretreatment with a low dose of TNFalpha (1.44 nM, 9 min) enhanced the sensitivity of transient receptor potential vanilloid type 1 (TRPV1) receptors in these neurons in two distinct phases: the inward current evoked by capsaicin was amplified (Delta = 247%) immediately following the TNFalpha pretreatment, which gradually declined toward control and then increased again reaching another peak (Delta = 384%) after 60-90 min.	Capsaicin	235-244	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	148-153
28317708-4	2017	The proposed voltammetric platform, RuNPs/CNTs/GCE, highly improved the voltammetric process of capsaicin in comparison to the CNTs/GCE and bare GCE.	Capsaicin	96-105	aminomethyltransferase	Homo sapiens	47-50
28392320-7	2017	The geometric mean of capsaicin causing &gt;=5 coughs (C5) increased from 134 to 203 muM in non-smokers and from 117 to 287 muM in asthmatics after AMP, whereas it decreased from 203 to 165 muM and 125 to 88 muM, respectively after ATP.	Capsaicin	22-31	latexin	Homo sapiens	124-127
28392320-7	2017	The geometric mean of capsaicin causing &gt;=5 coughs (C5) increased from 134 to 203 muM in non-smokers and from 117 to 287 muM in asthmatics after AMP, whereas it decreased from 203 to 165 muM and 125 to 88 muM, respectively after ATP.	Capsaicin	22-31	latexin	Homo sapiens	124-127
28392320-7	2017	The geometric mean of capsaicin causing &gt;=5 coughs (C5) increased from 134 to 203 muM in non-smokers and from 117 to 287 muM in asthmatics after AMP, whereas it decreased from 203 to 165 muM and 125 to 88 muM, respectively after ATP.	Capsaicin	22-31	latexin	Homo sapiens	124-127
28631948-0	2017	Possible contribution of pannexin-1 to capsaicin-induced ATP release in rat nasal columnar epithelial cells.	Capsaicin	39-48	Pannexin 1	Rattus norvegicus	25-35
28722015-1	2017	TRPV1 is an ion channel activated by heat and pungent agents including capsaicin, and has been extensively studied in nociception of sensory neurons.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
28722015-5	2017	When activated by capsaicin, TRPV1 recruits more glutamatergic, but not GABAergic, terminals to OLM neurons in vitro.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
27443158-6	2017	In whole-cell patch-clamp and intracellular-free calcium ([Ca2+]) concentration (Fura-2) experiments, cumene hydroperoxide and ADP-ribose-induced TRPM2 currents in the neurons were inhibited by N-(p-amylcinnamoyl) anthranilic acid (ACA) and capsaicin-induced TRPV1 currents were inhibited by capsazepine (CPZ) incubations.	Capsaicin	241-250	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	146-151
28527956-0	2017	Comparison of the induction of c-fos-eGFP and Fos protein in the rat spinal cord and hypothalamus resulting from subcutaneous capsaicin or formalin injection.	Capsaicin	126-135	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	31-36
28527956-8	2017	Induction of eGFP in the OXT neurons was observed after capsaicin or formalin treatment, while Fos-LI in the OXT neurons was observed only after formalin treatment.	Capsaicin	56-65	oxytocin/neurophysin I prepropeptide	Rattus norvegicus	25-28
28631948-4	2017	We demonstrated that ATP release and CBF were significantly potentiated by the heat-sensitive TRPV1 agonist capsaicin (10 muM), but not by other TRP agonists.	Capsaicin	108-117	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	94-99
28631948-5	2017	Capsaicin-induced ATP release and CBF increase were significantly inhibited by the pannexin-1 blockers carbenoxolone (10 muM) and probenecid (300 muM).	Capsaicin	0-9	Pannexin 1	Rattus norvegicus	83-93
28631948-6	2017	In addition, the voltage step-evoked currents in the presence of capsaicin were inhibited by the pannexin-1 blockers in single-cell patch clamping.	Capsaicin	65-74	Pannexin 1	Rattus norvegicus	97-107
28371926-6	2017	CGRP release from dissected PVAT, measured using EIA, was increased by capsaicin which activates sensory nerves.	Capsaicin	71-80	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
28429852-11	2017	Inhibition of CXCL10/CXCR3 and NF-kappaB (especially in astrocytes and microglia/macrophage) was involved in capsaicin-induced retinal protection through endogenous somatostatin.	Capsaicin	109-118	C-X-C motif chemokine ligand 10	Homo sapiens	14-20
28429852-11	2017	Inhibition of CXCL10/CXCR3 and NF-kappaB (especially in astrocytes and microglia/macrophage) was involved in capsaicin-induced retinal protection through endogenous somatostatin.	Capsaicin	109-118	C-X-C motif chemokine receptor 3	Homo sapiens	21-26
28429852-11	2017	Inhibition of CXCL10/CXCR3 and NF-kappaB (especially in astrocytes and microglia/macrophage) was involved in capsaicin-induced retinal protection through endogenous somatostatin.	Capsaicin	109-118	nuclear factor kappa B subunit 1	Homo sapiens	31-40
28182310-6	2017	ARMS sensitizes TRPV1 towards capsaicin in transfected HEK 293 cells and in mouse DRG neurons in a PKA-dependent manner.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-21
28182310-7	2017	Using a combination of functional imaging and immunocytochemistry, we show that the magnitude of the capsaicin response in DRG neurons depends not only on TRPV1 expression, but on the co-expression of ARMS alongside TRPV1.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	155-160
28182310-7	2017	Using a combination of functional imaging and immunocytochemistry, we show that the magnitude of the capsaicin response in DRG neurons depends not only on TRPV1 expression, but on the co-expression of ARMS alongside TRPV1.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	216-221
28388364-8	2017	Piezo2-like currents were observed almost exclusively in IB4-negative DPA neurons, with the current amplitude larger in capsaicin-insensitive DPA neurons than the capsaicin-sensitive population.	Capsaicin	120-129	piezo-type mechanosensitive ion channel component 2	Mus musculus	0-6
28217947-0	2017	Mechanism of capsaicin inhibition of aldose reductase activity.	Capsaicin	13-22	aldo-keto reductase family 1 member B1	Rattus norvegicus	37-53
28217947-3	2017	The aim of this study is to determine the in vitro inhibition behavior of capsaicin on AR enzyme activity, which was obtained from different rat tissues (heart, kidney, liver, and brain).	Capsaicin	74-83	aldo-keto reductase family 1 member B1	Rattus norvegicus	87-89
28217947-4	2017	We showed that AR was inhibited by capsaicin in the micromolar range and noncompetitive manner in all of the tissues.	Capsaicin	35-44	aldo-keto reductase family 1 member B1	Rattus norvegicus	15-17
28217947-5	2017	Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR.	Capsaicin	13-22	aldo-keto reductase family 1 member B1	Rattus norvegicus	88-90
28217947-5	2017	Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR.	Capsaicin	13-22	aldo-keto reductase family 1 member B1	Rattus norvegicus	99-101
28217947-5	2017	Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR.	Capsaicin	13-22	aldo-keto reductase family 1 member B1	Rattus norvegicus	99-101
28217947-5	2017	Ki values of capsaicin were found to be 8.87, 264, 535, and 597, respectively, in heart AR, kidney AR, liver AR, and brain AR.	Capsaicin	13-22	aldo-keto reductase family 1 member B1	Rattus norvegicus	99-101
28571526-3	2017	By reverse transcription polymerase chain reaction, we demonstrate that the calcium-permeable ion channels TRPA1, TRPV1, and its capsaicin-insensitive isoform TRPV1b are expressed in human gingival fibroblasts (HGFs), the most abundant cellular type in periodontal tissue.	Capsaicin	129-138	transient receptor potential cation channel subfamily A member 1	Homo sapiens	107-112
28139023-7	2017	LEP PtP amplitudes on capsaicin-irritated skin, reflecting peripheral/spinal sensitization, as in neuropathic pain, were reduced by pregabalin (-3.78 muV; 95% CI -5.31, -2.25) and duloxetine (-2.32 muV; 95% CI -3.82, -0.82) but not by celecoxib or lacosamide vs. placebo, which was in agreement with known clinical profiles.	Capsaicin	22-31	leptin	Homo sapiens	0-3
28139023-7	2017	LEP PtP amplitudes on capsaicin-irritated skin, reflecting peripheral/spinal sensitization, as in neuropathic pain, were reduced by pregabalin (-3.78 muV; 95% CI -5.31, -2.25) and duloxetine (-2.32 muV; 95% CI -3.82, -0.82) but not by celecoxib or lacosamide vs. placebo, which was in agreement with known clinical profiles.	Capsaicin	22-31	protein tyrosine phosphatase receptor type U	Homo sapiens	4-7
28388364-8	2017	Piezo2-like currents were observed almost exclusively in IB4-negative DPA neurons, with the current amplitude larger in capsaicin-insensitive DPA neurons than the capsaicin-sensitive population.	Capsaicin	163-172	piezo-type mechanosensitive ion channel component 2	Mus musculus	0-6
28665321-0	2017	Capsaicin-Sensitive Sensory Nerves Are Necessary for the Protective Effect of Ghrelin in Cerulein-Induced Acute Pancreatitis in Rats.	Capsaicin	0-9	ghrelin and obestatin prepropeptide	Rattus norvegicus	78-85
28526335-3	2017	The nociception that was triggered by capsaicin, an agonist of the TRPV1 vanilloid receptor, was totally blocked by 100 pmol/site, i.t.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	67-72
28404507-9	2017	Under stimulatory conditions, paclitaxel attenuated the membrane translocation of phosphorylated PKC alpha, betaI and betaII, providing a rationale for the attenuation in PDBu- and capsaicin-stimulated release.	Capsaicin	181-190	protein kinase C alpha	Homo sapiens	97-124
28644386-0	2017	Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	109-112
28658281-1	2017	BACKGROUND: Transient receptor potential cation channel subfamily V member 1 (TRPV1) are sensitive to heat, capsaicin, pungent chemicals and other noxious stimuli.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-76
28658281-1	2017	BACKGROUND: Transient receptor potential cation channel subfamily V member 1 (TRPV1) are sensitive to heat, capsaicin, pungent chemicals and other noxious stimuli.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	78-83
28644386-0	2017	Capsaicin Induces Autophagy and Apoptosis in Human Nasopharyngeal Carcinoma Cells by Downregulating the PI3K/AKT/mTOR Pathway.	Capsaicin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	113-117
28644386-6	2017	Western blotting and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) were used to measure capsaicin-induced autophagy via involvement of the class III PI3K/Beclin-1/Bcl-2 signaling pathway.	Capsaicin	123-132	beclin 1	Homo sapiens	189-197
28644386-6	2017	Western blotting and quantitative real-time reverse transcription polymerase chain reaction (qRT-PCR) were used to measure capsaicin-induced autophagy via involvement of the class III PI3K/Beclin-1/Bcl-2 signaling pathway.	Capsaicin	123-132	BCL2 apoptosis regulator	Homo sapiens	198-203
28644386-7	2017	Capsaicin induced autophagy by increasing levels of the autophagy markers LC3-II and Atg5, enhancing p62 and Fap-1 degradation and increasing caspase-3 activity to induce apoptosis, suggesting a correlation of blocking the PI3K/Akt/mTOR pathway with the above-mentioned anticancer activities.	Capsaicin	0-9	autophagy related 5	Homo sapiens	85-89
28644386-7	2017	Capsaicin induced autophagy by increasing levels of the autophagy markers LC3-II and Atg5, enhancing p62 and Fap-1 degradation and increasing caspase-3 activity to induce apoptosis, suggesting a correlation of blocking the PI3K/Akt/mTOR pathway with the above-mentioned anticancer activities.	Capsaicin	0-9	nucleoporin 62	Homo sapiens	101-104
28644386-7	2017	Capsaicin induced autophagy by increasing levels of the autophagy markers LC3-II and Atg5, enhancing p62 and Fap-1 degradation and increasing caspase-3 activity to induce apoptosis, suggesting a correlation of blocking the PI3K/Akt/mTOR pathway with the above-mentioned anticancer activities.	Capsaicin	0-9	protein tyrosine phosphatase non-receptor type 13	Homo sapiens	109-114
28644386-7	2017	Capsaicin induced autophagy by increasing levels of the autophagy markers LC3-II and Atg5, enhancing p62 and Fap-1 degradation and increasing caspase-3 activity to induce apoptosis, suggesting a correlation of blocking the PI3K/Akt/mTOR pathway with the above-mentioned anticancer activities.	Capsaicin	0-9	caspase 3	Homo sapiens	142-151
28644386-7	2017	Capsaicin induced autophagy by increasing levels of the autophagy markers LC3-II and Atg5, enhancing p62 and Fap-1 degradation and increasing caspase-3 activity to induce apoptosis, suggesting a correlation of blocking the PI3K/Akt/mTOR pathway with the above-mentioned anticancer activities.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	228-231
28644386-7	2017	Capsaicin induced autophagy by increasing levels of the autophagy markers LC3-II and Atg5, enhancing p62 and Fap-1 degradation and increasing caspase-3 activity to induce apoptosis, suggesting a correlation of blocking the PI3K/Akt/mTOR pathway with the above-mentioned anticancer activities.	Capsaicin	0-9	mechanistic target of rapamycin kinase	Homo sapiens	232-236
27401946-5	2017	However, capsaicin pre-treatment significantly suppressed the spermatogenic cell death, oxidative stress (levels of MDA, PHGPx immunoreactivity, and Hsp72, PHGPx, and MnSOD mRNA) and apoptosis (levels of TUNEL-positive cells, and Bcl-xL and Bax mRNA) in testes by HS.	Capsaicin	9-18	glutathione peroxidase 4	Mus musculus	121-126
28640864-1	2017	There is convincing epidemiological and experimental evidence that capsaicin, a potent natural transient receptor potential cation channel vanilloid member 1 (TRPV1) agonist, has anticancer activity.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	159-164
28640864-7	2017	The fraction of apoptotic cells was increased after 3 days incubation with capsaicin (10 muM) paralleled by increased reactive oxygen species production and caspase activity.	Capsaicin	75-84	latexin	Homo sapiens	89-92
28640864-9	2017	Capsazepine, a TRPV1 blocker, inhibited both the effect of capsaicin and MRS1477.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
28640864-10	2017	Whole-cell patch clamp recordings revealed that capsaicin-evoked TRPV1-mediated current density levels were increased after 3 days incubation with MRS1477 (2 muM).	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
28640864-10	2017	Whole-cell patch clamp recordings revealed that capsaicin-evoked TRPV1-mediated current density levels were increased after 3 days incubation with MRS1477 (2 muM).	Capsaicin	48-57	latexin	Homo sapiens	158-161
28659824-8	2017	The Cap-evoked Ca2+ influx was markedly enhanced in the neurons incubated with TNFalpha (50 ng/ml) for ~24 h, and this sensitizing effect was attenuated in the neurons isolated from the TNF-receptor double homozygous mutant mice.	Capsaicin	4-7	tumor necrosis factor	Mus musculus	79-87
28659824-8	2017	The Cap-evoked Ca2+ influx was markedly enhanced in the neurons incubated with TNFalpha (50 ng/ml) for ~24 h, and this sensitizing effect was attenuated in the neurons isolated from the TNF-receptor double homozygous mutant mice.	Capsaicin	4-7	tumor necrosis factor	Mus musculus	79-82
28559374-4	2017	Examination of EPSCs revealed the targeting of gamma-2 to be synapse-specific; the amplitude of spontaneously occurring miniature EPSCs (mEPSCs) was reduced in neurons from stg/stg mice, but the amplitude of capsaicin-induced mEPSCs from C-fiber synapses was unaltered.	Capsaicin	208-217	gamma-aminobutyric acid (GABA) A receptor, subunit gamma 2	Mus musculus	47-54
28445156-6	2017	However, dietary capsaicin significantly increased PPAR-alpha expression in adipose tissue, while antibiotics had no such effect.	Capsaicin	17-26	peroxisome proliferator activated receptor alpha	Mus musculus	51-61
27401946-5	2017	However, capsaicin pre-treatment significantly suppressed the spermatogenic cell death, oxidative stress (levels of MDA, PHGPx immunoreactivity, and Hsp72, PHGPx, and MnSOD mRNA) and apoptosis (levels of TUNEL-positive cells, and Bcl-xL and Bax mRNA) in testes by HS.	Capsaicin	9-18	heat shock protein 1A	Mus musculus	149-154
27401946-5	2017	However, capsaicin pre-treatment significantly suppressed the spermatogenic cell death, oxidative stress (levels of MDA, PHGPx immunoreactivity, and Hsp72, PHGPx, and MnSOD mRNA) and apoptosis (levels of TUNEL-positive cells, and Bcl-xL and Bax mRNA) in testes by HS.	Capsaicin	9-18	glutathione peroxidase 4	Mus musculus	156-161
27401946-5	2017	However, capsaicin pre-treatment significantly suppressed the spermatogenic cell death, oxidative stress (levels of MDA, PHGPx immunoreactivity, and Hsp72, PHGPx, and MnSOD mRNA) and apoptosis (levels of TUNEL-positive cells, and Bcl-xL and Bax mRNA) in testes by HS.	Capsaicin	9-18	superoxide dismutase 2, mitochondrial	Mus musculus	167-172
27401946-5	2017	However, capsaicin pre-treatment significantly suppressed the spermatogenic cell death, oxidative stress (levels of MDA, PHGPx immunoreactivity, and Hsp72, PHGPx, and MnSOD mRNA) and apoptosis (levels of TUNEL-positive cells, and Bcl-xL and Bax mRNA) in testes by HS.	Capsaicin	9-18	BCL2-like 1	Mus musculus	230-236
28235621-11	2017	Longer-term effects of capsaicinoid supplementation on basal insulin and cholesterol levels warrant further investigation.	Capsaicin	23-35	insulin	Homo sapiens	61-68
27401946-5	2017	However, capsaicin pre-treatment significantly suppressed the spermatogenic cell death, oxidative stress (levels of MDA, PHGPx immunoreactivity, and Hsp72, PHGPx, and MnSOD mRNA) and apoptosis (levels of TUNEL-positive cells, and Bcl-xL and Bax mRNA) in testes by HS.	Capsaicin	9-18	BCL2-associated X protein	Mus musculus	241-244
28439004-5	2017	The pungent molecule capsaicin (CP) has a similar effect as AEA; however, CP acts by engagement of the vanilloid receptor TRPV1, causing local production of AEA, which acts through CB2.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	122-127
28012561-11	2017	F13A administration alone significantly accelerated the basal CT. Apelin-13 noticeably disturbed the duodenal fasting motor pattern by impairing phase III-like contractions while increasing the amplitudes of phase II contractions which were prevented by pretreatment of lorglumide and capsaicin.	Capsaicin	285-294	apelin	Rattus norvegicus	66-72
28012561-12	2017	Compared with vehicle-treated rats, lorglumide and capsaicin significantly (p&lt;0.05) reduced the apelin-13-induced increases in phase II motility index.	Capsaicin	51-60	apelin	Rattus norvegicus	99-105
28418433-4	2017	Capsaicin decreased 4-aminopyridine-evoked intrasynaptosomal Ca2+ concentration elevation and the capsaicin-mediated inhibition of glutamate release was prevented by the Cav2.2 (N-type) and Cav2.1 (P/Q-type) channel blocker omega-conotoxin MVIIC, but was not affected by the intracellular Ca2+-release inhibitors dantrolene and CGP37157.	Capsaicin	98-107	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	190-196
28418433-7	2017	Together, these results suggest that capsaicin acts at TRPV1 present on hippocampal nerve terminals to increase calcineurin activation, which subsequently attenuates voltage-dependent Ca2+ entry to cause a decrease in evoked glutamate release.	Capsaicin	37-46	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-60
28336810-5	2017	In guinea pig tracheal ring organ bath experiments, the TRPV1 agonist capsaicin led to ASM contraction, but this contraction was significantly attenuated by the sodium channel inhibitor bupivacaine (n = 4, P &lt; 0.05) and the neurokinin-2 receptor antagonist GR-159897 (n = 4, P &lt; 0.05), suggesting that this contraction is neutrally mediated.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	56-61
28102715-0	2017	Capsaicin pretreatment enhanced the bioavailability of fexofenadine in rats by P-glycoprotein modulation: in vitro, in situ and in vivo evaluation.	Capsaicin	0-9	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	79-93
28102715-1	2017	BACKGROUND AND OBJECTIVE: Capsaicin is the main pungent principle present in chili peppers has been found to possess P-glycoprotein (P-gp) inhibition activity in vitro, which may have the potential to modulate bioavailability of P-gp substrates.	Capsaicin	26-35	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	117-131
28102715-1	2017	BACKGROUND AND OBJECTIVE: Capsaicin is the main pungent principle present in chili peppers has been found to possess P-glycoprotein (P-gp) inhibition activity in vitro, which may have the potential to modulate bioavailability of P-gp substrates.	Capsaicin	26-35	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	133-137
28102715-1	2017	BACKGROUND AND OBJECTIVE: Capsaicin is the main pungent principle present in chili peppers has been found to possess P-glycoprotein (P-gp) inhibition activity in vitro, which may have the potential to modulate bioavailability of P-gp substrates.	Capsaicin	26-35	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	229-233
28102715-9	2017	CONCLUSIONS: Capsaicin pretreatment significantly enhanced the intestinal absorption and bioavailability of fexofenadine in rats likely by inhibition of P-gp mediated cellular efflux, suggesting that the combined use of capsaicin with P-gp substrates may require close monitoring for potential drug interactions.	Capsaicin	13-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	153-157
28102715-9	2017	CONCLUSIONS: Capsaicin pretreatment significantly enhanced the intestinal absorption and bioavailability of fexofenadine in rats likely by inhibition of P-gp mediated cellular efflux, suggesting that the combined use of capsaicin with P-gp substrates may require close monitoring for potential drug interactions.	Capsaicin	13-22	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	235-239
28188907-2	2017	NEO6860 is a TRPV1 antagonist, blocking capsaicin activation of the target, with little or no effect against pH or heat activation.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
28188907-16	2017	PERSPECTIVE: This first in human study on NEO6860, showed that an antagonist of TRPV1, blocking only the activation by capsaicin has been identified.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	80-85
28418433-0	2017	Capsaicin presynaptically inhibits glutamate release through the activation of TRPV1 and calcineurin in the hippocampus of rats.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
28418433-4	2017	Capsaicin decreased 4-aminopyridine-evoked intrasynaptosomal Ca2+ concentration elevation and the capsaicin-mediated inhibition of glutamate release was prevented by the Cav2.2 (N-type) and Cav2.1 (P/Q-type) channel blocker omega-conotoxin MVIIC, but was not affected by the intracellular Ca2+-release inhibitors dantrolene and CGP37157.	Capsaicin	0-9	calcium voltage-gated channel subunit alpha1 A	Rattus norvegicus	190-196
28360106-0	2017	Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1.	Capsaicin	25-34	carbonic anhydrase 2	Mus musculus	0-3
28360106-0	2017	Ca2+ and calpain mediate capsaicin-induced ablation of axonal terminals expressing transient receptor potential vanilloid 1.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	83-123
28360106-1	2017	Capsaicin is an ingredient in spicy peppers that produces burning pain by activating transient receptor potential vanilloid 1 (TRPV1), a Ca2+-permeable ion channel in nociceptors.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	85-125
28360106-1	2017	Capsaicin is an ingredient in spicy peppers that produces burning pain by activating transient receptor potential vanilloid 1 (TRPV1), a Ca2+-permeable ion channel in nociceptors.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	127-132
28360106-1	2017	Capsaicin is an ingredient in spicy peppers that produces burning pain by activating transient receptor potential vanilloid 1 (TRPV1), a Ca2+-permeable ion channel in nociceptors.	Capsaicin	0-9	carbonic anhydrase 2	Mus musculus	137-140
28360106-6	2017	Using a combination of these TRPV1-lineage reporter mice and primary afferent cultures, we monitored capsaicin-induced effects on afferent terminals in real time.	Capsaicin	101-110	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
28360106-7	2017	We found that Ca2+ influx through TRPV1 is necessary for capsaicin-induced ablation of nociceptive terminals.	Capsaicin	57-66	carbonic anhydrase 2	Mus musculus	14-17
28360106-7	2017	We found that Ca2+ influx through TRPV1 is necessary for capsaicin-induced ablation of nociceptive terminals.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	34-39
28360106-8	2017	Although capsaicin-induced mitochondrial Ca2+ uptake was TRPV1-dependent, dissipation of the mitochondrial membrane potential, inhibition of the mitochondrial transition permeability pore, and scavengers of reactive oxygen species did not attenuate capsaicin-induced ablation.	Capsaicin	9-18	carbonic anhydrase 2	Mus musculus	41-44
28360106-8	2017	Although capsaicin-induced mitochondrial Ca2+ uptake was TRPV1-dependent, dissipation of the mitochondrial membrane potential, inhibition of the mitochondrial transition permeability pore, and scavengers of reactive oxygen species did not attenuate capsaicin-induced ablation.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	57-62
28360106-11	2017	Quantitative assessment of TRPV1-lineage afferents in the epidermis of the hind paws of the reporter mice showed that EGTA and MDL28170 diminished capsaicin-induced ablation.	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
28360106-13	2017	These results suggest that TRPV1/Ca2+/calpain-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
28360106-13	2017	These results suggest that TRPV1/Ca2+/calpain-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.	Capsaicin	91-100	carbonic anhydrase 2	Mus musculus	33-36
28360106-13	2017	These results suggest that TRPV1/Ca2+/calpain-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.	Capsaicin	227-236	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
28360106-13	2017	These results suggest that TRPV1/Ca2+/calpain-dependent signaling plays a dominant role in capsaicin-induced ablation of nociceptive terminals and further our understanding of the molecular mechanisms underlying the effects of capsaicin on nociceptors.	Capsaicin	227-236	carbonic anhydrase 2	Mus musculus	33-36
28439004-5	2017	The pungent molecule capsaicin (CP) has a similar effect as AEA; however, CP acts by engagement of the vanilloid receptor TRPV1, causing local production of AEA, which acts through CB2.	Capsaicin	21-30	cannabinoid receptor 2 (macrophage)	Mus musculus	181-184
28095752-1	2017	Transient receptor potential vanilloid 1 (TRPV1) was identified as a receptor of capsaicin, which is a pungent ingredient in hot red peppers.	Capsaicin	81-90	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
28475608-1	2017	TRPV1 (vanilloid) receptors are activated by different types of stimuli including capsaicin, acidification and heat.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
28475608-4	2017	The APHCs potentiated TRPV1 responses to low (3-300 nM) concentrations of capsaicin but inhibited responses to high (&gt;3.0 muM) concentrations.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
28515697-5	2017	TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively.	Capsaicin	51-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
28515697-5	2017	TRPV1 and TRPA1 channel activations were evoked by capsaicin (1 muM), a TRPV1 agonist, and allyl isothiocyanate (AITC; 500 muM), a TRPA1 agonist, respectively.	Capsaicin	51-60	transient receptor potential cation channel subfamily A member 1	Homo sapiens	10-15
28781729-3	2017	The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain.	Capsaicin	137-146	carbonic anhydrase 1	Rattus norvegicus	67-70
28781729-3	2017	The current study was designed to investigate the possible role of CA1-hippocampal OX1R on spatial learning and memory of rats following capsaicin-induced orofacial pain.	Capsaicin	137-146	hypocretin receptor 1	Rattus norvegicus	83-87
28781729-8	2017	In addition, pretreatment with orexin A (20 and 40 nM/rat) significantly attenuated learning and memory impairment in capsaicin-treated rats.	Capsaicin	118-127	hypocretin neuropeptide precursor	Rattus norvegicus	31-39
28781729-9	2017	Conversely, blockage of OX1R via SB-334867-A (40 and 80 nM/rat) significantly exaggerated learning and memory loss in capsaicin-treated rats.	Capsaicin	118-127	hypocretin receptor 1	Rattus norvegicus	24-28
28781729-10	2017	CONCLUSION: The obtained results indicated that CA1 OX1R may be involved in modulation of capsaicin -induced spatial learning and memory impairment.	Capsaicin	90-99	carbonic anhydrase 1	Rattus norvegicus	48-51
28781729-10	2017	CONCLUSION: The obtained results indicated that CA1 OX1R may be involved in modulation of capsaicin -induced spatial learning and memory impairment.	Capsaicin	90-99	hypocretin receptor 1	Rattus norvegicus	52-56
28095752-1	2017	Transient receptor potential vanilloid 1 (TRPV1) was identified as a receptor of capsaicin, which is a pungent ingredient in hot red peppers.	Capsaicin	81-90	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
27021021-15	2017	The TRPV1 channel is activated by oxidative stress and capsaicin, and it is blocked by capsazepine (CPZ).	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
28104916-4	2017	SUBJECTS/METHODS: We investigated the effect of dietary supplementation of capsaicin (CAP) (TRPV1 agonist) on the expression of metabolically important thermogenic proteins in BAT of wild-type and TRPV1-/- mice that received either a normal chow or high-fat (+-CAP; TRPV1 activator) diet by immunoblotting.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-97
28104916-4	2017	SUBJECTS/METHODS: We investigated the effect of dietary supplementation of capsaicin (CAP) (TRPV1 agonist) on the expression of metabolically important thermogenic proteins in BAT of wild-type and TRPV1-/- mice that received either a normal chow or high-fat (+-CAP; TRPV1 activator) diet by immunoblotting.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	197-202
28104916-4	2017	SUBJECTS/METHODS: We investigated the effect of dietary supplementation of capsaicin (CAP) (TRPV1 agonist) on the expression of metabolically important thermogenic proteins in BAT of wild-type and TRPV1-/- mice that received either a normal chow or high-fat (+-CAP; TRPV1 activator) diet by immunoblotting.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	197-202
28062311-6	2017	Capsaicin-induced pain was reduced by the TRPV1 inhibitor BCTC.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
28112976-5	2017	Compared to the control group, the group treated with capsaicin (TRPV1 agonist) had better scores in the PAL acquisition and retention test, whereas treatment with WIN55,212-2 (CB1/CB2 agonist) decreased the test scores.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	65-70
28435977-6	2017	The result showed that capsaicin (25 and 50 mumol/L) remarkably reduced the abilities of migration and invasion (P &lt; 0.05), inhibited the phosphorylation of c-Src, FAK and Paxillin (P &lt; 0.05), and down-regulated MMP2 and MMP9 expressions at mRNA and protein levels (P &lt; 0.05) in MDA-MB-231 cells.	Capsaicin	23-32	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	160-165
28435977-6	2017	The result showed that capsaicin (25 and 50 mumol/L) remarkably reduced the abilities of migration and invasion (P &lt; 0.05), inhibited the phosphorylation of c-Src, FAK and Paxillin (P &lt; 0.05), and down-regulated MMP2 and MMP9 expressions at mRNA and protein levels (P &lt; 0.05) in MDA-MB-231 cells.	Capsaicin	23-32	protein tyrosine kinase 2	Homo sapiens	167-170
28435977-6	2017	The result showed that capsaicin (25 and 50 mumol/L) remarkably reduced the abilities of migration and invasion (P &lt; 0.05), inhibited the phosphorylation of c-Src, FAK and Paxillin (P &lt; 0.05), and down-regulated MMP2 and MMP9 expressions at mRNA and protein levels (P &lt; 0.05) in MDA-MB-231 cells.	Capsaicin	23-32	paxillin	Homo sapiens	175-183
28435977-6	2017	The result showed that capsaicin (25 and 50 mumol/L) remarkably reduced the abilities of migration and invasion (P &lt; 0.05), inhibited the phosphorylation of c-Src, FAK and Paxillin (P &lt; 0.05), and down-regulated MMP2 and MMP9 expressions at mRNA and protein levels (P &lt; 0.05) in MDA-MB-231 cells.	Capsaicin	23-32	matrix metallopeptidase 2	Homo sapiens	218-222
28435977-6	2017	The result showed that capsaicin (25 and 50 mumol/L) remarkably reduced the abilities of migration and invasion (P &lt; 0.05), inhibited the phosphorylation of c-Src, FAK and Paxillin (P &lt; 0.05), and down-regulated MMP2 and MMP9 expressions at mRNA and protein levels (P &lt; 0.05) in MDA-MB-231 cells.	Capsaicin	23-32	matrix metallopeptidase 9	Homo sapiens	227-231
28435977-8	2017	These results suggest that capsaicin may suppress the migration and invasion of breast cancer MDA-MB-231 cells by inhibiting the phosphorylations of c-Src, FAK and Paxillin, and down-regulating the mRNA and protein levels of MMP2 and MMP9.	Capsaicin	27-36	SRC proto-oncogene, non-receptor tyrosine kinase	Homo sapiens	149-154
28496430-11	2017	Both nicotine and carbachol induced intracellular Ca2+ transients in trigeminal neurons partially overlapping with expression of capsaicin-sensitive TRPV1 receptors.	Capsaicin	129-138	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	149-154
28435977-8	2017	These results suggest that capsaicin may suppress the migration and invasion of breast cancer MDA-MB-231 cells by inhibiting the phosphorylations of c-Src, FAK and Paxillin, and down-regulating the mRNA and protein levels of MMP2 and MMP9.	Capsaicin	27-36	protein tyrosine kinase 2	Homo sapiens	156-159
28435977-8	2017	These results suggest that capsaicin may suppress the migration and invasion of breast cancer MDA-MB-231 cells by inhibiting the phosphorylations of c-Src, FAK and Paxillin, and down-regulating the mRNA and protein levels of MMP2 and MMP9.	Capsaicin	27-36	paxillin	Homo sapiens	164-172
28435977-8	2017	These results suggest that capsaicin may suppress the migration and invasion of breast cancer MDA-MB-231 cells by inhibiting the phosphorylations of c-Src, FAK and Paxillin, and down-regulating the mRNA and protein levels of MMP2 and MMP9.	Capsaicin	27-36	matrix metallopeptidase 2	Homo sapiens	225-229
28435977-8	2017	These results suggest that capsaicin may suppress the migration and invasion of breast cancer MDA-MB-231 cells by inhibiting the phosphorylations of c-Src, FAK and Paxillin, and down-regulating the mRNA and protein levels of MMP2 and MMP9.	Capsaicin	27-36	matrix metallopeptidase 9	Homo sapiens	234-238
28094445-5	2017	In spinal cord slices, clonidine reduced the frequency of capsaicin-induced miniature EPSCs in the presence of tetrodotoxin and omega-conotoxin-MVIIC, consistent with inhibition of presynaptic TRPV1 channels by alpha2 adrenergic receptors.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	193-198
28094445-13	2017	In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that activation of adrenergic receptors in DRG neurons is preferentially linked to CaMKII activity.	Capsaicin	148-157	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	22-68
28094445-13	2017	In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that activation of adrenergic receptors in DRG neurons is preferentially linked to CaMKII activity.	Capsaicin	148-157	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	70-76
28094445-13	2017	In contrast, when the calcium/calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of noradrenaline on the capsaicin-activated current was greatly reduced, suggesting that activation of adrenergic receptors in DRG neurons is preferentially linked to CaMKII activity.	Capsaicin	148-157	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	291-297
28188777-5	2017	The data showed that the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) and the amplitudes of evoked excitatory postsynaptic currents (eEPSCs) were increased during morphine withdrawal after applied with capsaicin (TRPV1 agonist).	Capsaicin	224-233	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	235-240
28112976-7	2017	We conclude that the acute administration of a TRPV1 agonist improves the rats" cognitive performance in PAL tasks and that a vanilloid-related mechanism may underlie the agonistic effect of WIN55,212-2 on learning and memory.	Capsaicin	126-135	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	47-52
28438981-7	2017	Both formalin and PGE2 potentiated GABA-induced Ca2+ transients and membrane depolarization in capsaicin-sensitive nociceptive DRG neurons; these effects were blocked by the prostaglandin E2 receptor 4 (EP4) antagonist AH23848 (10 mumol/L).	Capsaicin	95-104	prostaglandin E receptor 4 (subtype EP4)	Mus musculus	203-206
28527512-3	2017	In the present study, the possible protective effect of capsaicin was studied against methyl methanesulphonate (MMS) induced toxicity in third instar larvae of transgenic Drosophila melanogaster (hsp70-lacZ)Bg9.	Capsaicin	56-65	Heat-shock-protein-70Ab	Drosophila melanogaster	196-201
27774580-6	2017	TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
27774580-6	2017	TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin.	Capsaicin	20-29	actin gamma 2, smooth muscle	Rattus norvegicus	68-77
27774580-6	2017	TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin.	Capsaicin	20-29	transgelin	Rattus norvegicus	82-91
27774580-6	2017	TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin.	Capsaicin	20-29	secreted phosphoprotein 1	Rattus norvegicus	115-118
27774580-6	2017	TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	247-252
27774580-6	2017	TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin.	Capsaicin	308-317	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
27774580-6	2017	TRPV1 activation by capsaicin significantly increased expression of alpha-SMA and SM22alpha, reduced expression of OPN, retarded proliferative and migratory capacities and inhibited inflammatory status in VSMCs from SHR, which was counteracted by TRPV1 antagonist 5"-iodoresiniferatoxin (iRTX) combined with capsaicin.	Capsaicin	308-317	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	247-252
27774580-7	2017	TRPV1 activation by capsaicin ameliorated intracranial arteriole remodeling in SHR and deoxycorticosterone acetate (DOCA)-salt hypertensive mice.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
27739618-3	2017	Prostaglandin E2 (PGE2) enriched in injured tissues is known not only directly to sensitize DRG neurons, but also to potentiate sensitizing effects of other pain mediators such as capsaicin and its receptor transient receptor potential vanilloid-1 (TRPV1).	Capsaicin	180-189	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	249-254
27774580-10	2017	Taken together, we provide evidence that TRPV1 activation by capsaicin attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation during hypertension, which may be at least partly attributed to the suppression PI3K/Akt signaling pathway.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	41-46
27774580-10	2017	Taken together, we provide evidence that TRPV1 activation by capsaicin attenuates intracranial arteriole remodeling through inhibiting VSMC phenotypic modulation during hypertension, which may be at least partly attributed to the suppression PI3K/Akt signaling pathway.	Capsaicin	61-70	AKT serine/threonine kinase 1	Rattus norvegicus	247-250
26957303-18	2017	The TRPV1 channel is activated by oxidative stress and capsaicin and it is blocked by capsazepine (CPZ).	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
28291541-5	2017	Applying agonist of either transient receptor potential vanilloid 1 (TRPV1) or transient receptor potential ankyrin 1 (TRPA1) receptor (capsaicin or mustard oil, respectively) to the nerve-transected paw inhibited the plantar incision-induced drop of the noxious heat threshold on the contralateral paw.	Capsaicin	136-145	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	79-117
28291541-5	2017	Applying agonist of either transient receptor potential vanilloid 1 (TRPV1) or transient receptor potential ankyrin 1 (TRPA1) receptor (capsaicin or mustard oil, respectively) to the nerve-transected paw inhibited the plantar incision-induced drop of the noxious heat threshold on the contralateral paw.	Capsaicin	136-145	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	119-124
28213106-12	2017	For mice injected with capsaicin, a TRPV1 activator, EOHs (1000mg/kg, ED50 =660mg/kg) showed decreased (63%) nociceptive behavior.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	36-41
28230360-8	2017	Analysis of the related genes suggested that the transient receptor potential vanilloid 1 (TRPV1) receptor was activated by capsaicin.	Capsaicin	124-133	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-89
28230360-8	2017	Analysis of the related genes suggested that the transient receptor potential vanilloid 1 (TRPV1) receptor was activated by capsaicin.	Capsaicin	124-133	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
27979859-11	2017	Taken together, the capsaicin-mediated [Ca2+]cyt increase due to upregulated TRPV1 may be a critical pathogenic mechanism that contributes to augmented Ca2+ influx and excessive PASMC proliferation in patients with IPAH.	Capsaicin	20-29	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
28153725-3	2017	However, it was reported that transient receptor potential vanilloid 1 (TRPV1) channel antagonist capsazepine (CPZ; a capsaicin analogue) attenuates sepsis in a murine model [Ang et al., PLoS ONE 6(9) (2011) e24535; J. Immunol.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	30-70
28153725-3	2017	However, it was reported that transient receptor potential vanilloid 1 (TRPV1) channel antagonist capsazepine (CPZ; a capsaicin analogue) attenuates sepsis in a murine model [Ang et al., PLoS ONE 6(9) (2011) e24535; J. Immunol.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	72-77
27979859-0	2017	Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.	Capsaicin	0-9	carbonic anhydrase 2	Homo sapiens	18-21
27979859-0	2017	Capsaicin-induced Ca2+ signaling is enhanced via upregulated TRPV1 channels in pulmonary artery smooth muscle cells from patients with idiopathic PAH.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
27979859-2	2017	Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1) channels to increase cytosolic Ca2+ concentration ([Ca2+]cyt).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-63
28273917-0	2017	Alleviation of Microglial Activation Induced by p38 MAPK/MK2/PGE2 Axis by Capsaicin: Potential Involvement of other than TRPV1 Mechanism/s.	Capsaicin	74-83	MAPK activated protein kinase 2	Homo sapiens	57-60
28273917-3	2017	Here we have investigated the hitherto unknown effects of capsaicin (cap) - a transient receptor potential vanilloid 1 (TRPV1) agonist- in murine primary microglia, organotypic hippocampal slice cultures (OHSCs) and human primary monocytes.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	120-125
28273917-4	2017	Results demonstrate that cap (0.1-25 microM) significantly (p &lt; 0.05) inhibited the release of prostaglandin E2 (PGE2), 8-iso-PGF2alpha, and differentially regulated the levels of cytokines (TNF-alpha, IL-6 &amp; IL-1beta).	Capsaicin	25-28	tumor necrosis factor	Homo sapiens	194-203
28273917-4	2017	Results demonstrate that cap (0.1-25 microM) significantly (p &lt; 0.05) inhibited the release of prostaglandin E2 (PGE2), 8-iso-PGF2alpha, and differentially regulated the levels of cytokines (TNF-alpha, IL-6 &amp; IL-1beta).	Capsaicin	25-28	interleukin 6	Homo sapiens	205-209
28273917-4	2017	Results demonstrate that cap (0.1-25 microM) significantly (p &lt; 0.05) inhibited the release of prostaglandin E2 (PGE2), 8-iso-PGF2alpha, and differentially regulated the levels of cytokines (TNF-alpha, IL-6 &amp; IL-1beta).	Capsaicin	25-28	interleukin 1 beta	Homo sapiens	216-224
28062485-4	2017	In patch-clamp recordings with isolated rat vagal pulmonary sensory neurons, pretreatment with chloroquine (1-1,000 microM, 90 s) concentration dependently potentiated capsaicin-induced TRPV1-mediated inward currents.	Capsaicin	168-177	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	186-191
27979859-2	2017	Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1) channels to increase cytosolic Ca2+ concentration ([Ca2+]cyt).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
27979859-2	2017	Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1) channels to increase cytosolic Ca2+ concentration ([Ca2+]cyt).	Capsaicin	0-9	carbonic anhydrase 2	Homo sapiens	103-106
27979859-11	2017	Taken together, the capsaicin-mediated [Ca2+]cyt increase due to upregulated TRPV1 may be a critical pathogenic mechanism that contributes to augmented Ca2+ influx and excessive PASMC proliferation in patients with IPAH.	Capsaicin	20-29	carbonic anhydrase 2	Homo sapiens	152-155
27979859-2	2017	Capsaicin can activate transient receptor potential vanilloid 1 (TRPV1) channels to increase cytosolic Ca2+ concentration ([Ca2+]cyt).	Capsaicin	0-9	carbonic anhydrase 2	Homo sapiens	124-127
27979859-4	2017	In this study, we observed that a capsaicin-induced increase in [Ca2+]cyt was significantly enhanced in PASMCs from patients with idiopathic pulmonary arterial hypertension (IPAH) compared with normal PASMCs from healthy donors.	Capsaicin	34-43	carbonic anhydrase 2	Homo sapiens	65-68
28062485-7	2017	In summary, our study showed that activation of T2Rs augments capsaicin-evoked TRPV1 responses in rat pulmonary nociceptors through the phospholipase C and protein kinase C signaling pathway.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
28449493-0	2017	TRPV1 polymorphisms influence capsaicin cough sensitivity in men.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
28176363-5	2017	A concentration-dependent antinociceptive effect of the PCCA extract (20-160 mg/paw) was also demonstrated in the rat capsaicin (0.2%) test.	Capsaicin	118-127	propionyl-CoA carboxylase subunit alpha	Rattus norvegicus	56-60
27979980-9	2017	Intracellular calcium flux and IL-6 mRNA expression were increased by the TRPV1 agonists capsaicin and N-arachidonoyldopamine and decreased by the TRPV1 antagonists AMG9810 and SB366791 and siRNA-mediated knockdown of TRPV1.	Capsaicin	89-98	interleukin 6	Mus musculus	31-35
27979980-9	2017	Intracellular calcium flux and IL-6 mRNA expression were increased by the TRPV1 agonists capsaicin and N-arachidonoyldopamine and decreased by the TRPV1 antagonists AMG9810 and SB366791 and siRNA-mediated knockdown of TRPV1.	Capsaicin	89-98	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	74-79
28097492-7	2017	The H2O2-induced TRPM2 current densities were decreased by N-(p-amylcinnamoyl)anthranilic acid (ACA), and dose-dependent capsaicin (CAP) and H2O2-induced TRPV1 currents were inhibited by capsazepine (CPZ).	Capsaicin	121-130	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	17-22
28097492-7	2017	The H2O2-induced TRPM2 current densities were decreased by N-(p-amylcinnamoyl)anthranilic acid (ACA), and dose-dependent capsaicin (CAP) and H2O2-induced TRPV1 currents were inhibited by capsazepine (CPZ).	Capsaicin	132-135	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	17-22
28097492-7	2017	The H2O2-induced TRPM2 current densities were decreased by N-(p-amylcinnamoyl)anthranilic acid (ACA), and dose-dependent capsaicin (CAP) and H2O2-induced TRPV1 currents were inhibited by capsazepine (CPZ).	Capsaicin	132-135	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	154-159
28097492-8	2017	The TRPV1 channel is activated in the DRG neurons by 0.01 mM capsaicin but not 0.001 mM or 0.05 mM capsaicin.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
27979859-6	2017	Increasing the temperature from 23 to 43 C, or decreasing the extracellular pH value from 7.4 to 5.9 enhanced capsaicin-induced increases in [Ca2+]cyt; the acidity (pH 5.9)- and heat (43 C)-mediated enhancement of capsaicin-induced [Ca2+]cyt increases were greater in IPAH PASMCs than in normal PASMCs.	Capsaicin	110-119	carbonic anhydrase 2	Homo sapiens	142-145
27979859-6	2017	Increasing the temperature from 23 to 43 C, or decreasing the extracellular pH value from 7.4 to 5.9 enhanced capsaicin-induced increases in [Ca2+]cyt; the acidity (pH 5.9)- and heat (43 C)-mediated enhancement of capsaicin-induced [Ca2+]cyt increases were greater in IPAH PASMCs than in normal PASMCs.	Capsaicin	110-119	carbonic anhydrase 2	Homo sapiens	233-236
27979859-6	2017	Increasing the temperature from 23 to 43 C, or decreasing the extracellular pH value from 7.4 to 5.9 enhanced capsaicin-induced increases in [Ca2+]cyt; the acidity (pH 5.9)- and heat (43 C)-mediated enhancement of capsaicin-induced [Ca2+]cyt increases were greater in IPAH PASMCs than in normal PASMCs.	Capsaicin	214-223	carbonic anhydrase 2	Homo sapiens	142-145
27979859-8	2017	Inhibition of TRPV1 (with 5"-IRTX or capsazepine) or knockdown of TRPV1 (with short hairpin RNA) attenuated capsaicin-, acidity-, and osmotic stretch-mediated [Ca2+]cyt increases in IPAH PASMCs.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
27979859-8	2017	Inhibition of TRPV1 (with 5"-IRTX or capsazepine) or knockdown of TRPV1 (with short hairpin RNA) attenuated capsaicin-, acidity-, and osmotic stretch-mediated [Ca2+]cyt increases in IPAH PASMCs.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	66-71
27979859-8	2017	Inhibition of TRPV1 (with 5"-IRTX or capsazepine) or knockdown of TRPV1 (with short hairpin RNA) attenuated capsaicin-, acidity-, and osmotic stretch-mediated [Ca2+]cyt increases in IPAH PASMCs.	Capsaicin	108-117	carbonic anhydrase 2	Homo sapiens	160-163
27979859-9	2017	Capsaicin induced phosphorylation of CREB by raising [Ca2+]cyt, and capsaicin-induced CREB phosphorylation were significantly enhanced in IPAH PASMCs compared with normal PASMCs.	Capsaicin	0-9	cAMP responsive element binding protein 1	Homo sapiens	37-41
27979859-9	2017	Capsaicin induced phosphorylation of CREB by raising [Ca2+]cyt, and capsaicin-induced CREB phosphorylation were significantly enhanced in IPAH PASMCs compared with normal PASMCs.	Capsaicin	0-9	carbonic anhydrase 2	Homo sapiens	54-57
27979859-9	2017	Capsaicin induced phosphorylation of CREB by raising [Ca2+]cyt, and capsaicin-induced CREB phosphorylation were significantly enhanced in IPAH PASMCs compared with normal PASMCs.	Capsaicin	68-77	cAMP responsive element binding protein 1	Homo sapiens	86-90
27979859-11	2017	Taken together, the capsaicin-mediated [Ca2+]cyt increase due to upregulated TRPV1 may be a critical pathogenic mechanism that contributes to augmented Ca2+ influx and excessive PASMC proliferation in patients with IPAH.	Capsaicin	20-29	carbonic anhydrase 2	Homo sapiens	40-43
26360825-8	2017	The results from this study indicate that a standard restaurant meal containing a relatively small dose of capsaicin delivered via African bird"s eye chilli, which is currently available to the public, results in lower postprandial insulin concentrations in overweight individuals, compared with the same meal without chilli.	Capsaicin	107-116	insulin	Homo sapiens	232-239
28133727-8	2017	Capsaicin-induced changes in meningeal blood flow and release of calcitonin gene-related peptide (CGRP) from dural trigeminal afferents were measured in control and obese rats.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	65-96
28133727-8	2017	Capsaicin-induced changes in meningeal blood flow and release of calcitonin gene-related peptide (CGRP) from dural trigeminal afferents were measured in control and obese rats.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	98-102
28133727-13	2017	In obese animals, dural application of the archetypal TRPV1 agonist capsaicin resulted in significantly augmented vasodilatory and vasoconstrictor responses as compared to controls.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
28133727-14	2017	Diet-induced obesity was also associated with enhanced basal and capsaicin-induced CGRP release from meningeal afferents ex vivo.	Capsaicin	65-74	calcitonin-related polypeptide alpha	Rattus norvegicus	83-87
27321307-10	2017	TRPV1 activation by measuring the increase in Ca2+ induced by capsaicin in dorsal root ganglia neurons.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
27321307-14	2017	Capsaicin-induced calcium increase was higher in dorsal root ganglia cultures from PCS rats, indicating TRPV1functional increase.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	104-109
28280490-1	2017	Capsaicin (CAP) reduces body weight mainly through activation of transient receptor potential vanilloid 1 (TRPV1) cation channel.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-105
27975298-1	2017	Capsaicin activates transient receptor potential vanilloid 1 (TRPV1), a cation channel in the transient receptor potential family, resulting in the transient entry of Ca2+ and Mg2+ and a warm sensation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	62-67
27975298-5	2017	A 15-min stimulation with capsaicin (~100 muM) phosphorylated ERK and p38 MAPK and induced actin assembly.	Capsaicin	26-35	mitogen-activated protein kinase 14	Mus musculus	70-78
27975298-6	2017	A 2-day stimulation with capsaicin increased the level of HSP70, but not HSP90, and the 2-day stimulation with capsaicin (~100 muM) did not affect cell proliferation.	Capsaicin	25-34	heat shock protein 1B	Mus musculus	58-63
27975298-1	2017	Capsaicin activates transient receptor potential vanilloid 1 (TRPV1), a cation channel in the transient receptor potential family, resulting in the transient entry of Ca2+ and Mg2+ and a warm sensation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-60
28280490-1	2017	Capsaicin (CAP) reduces body weight mainly through activation of transient receptor potential vanilloid 1 (TRPV1) cation channel.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
28280490-1	2017	Capsaicin (CAP) reduces body weight mainly through activation of transient receptor potential vanilloid 1 (TRPV1) cation channel.	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-105
28280490-1	2017	Capsaicin (CAP) reduces body weight mainly through activation of transient receptor potential vanilloid 1 (TRPV1) cation channel.	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
28225806-2	2017	Capsaicin is a specific transient receptor potential vanilloid 1 (TRPV1) agonist which was proved to ameliorate insulin resistance.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-64
28225806-2	2017	Capsaicin is a specific transient receptor potential vanilloid 1 (TRPV1) agonist which was proved to ameliorate insulin resistance.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
28225806-12	2017	These results demonstrated that dietary capsaicin appears to prevent the hyperphosphorylation of AD-associated tau protein by increasing the activity of PI3K/AKT and inhibiting GSK-3beta in hippocampus of T2D rats, which supported that dietary capsaicin might have a potential use for the prevention of AD in T2D.	Capsaicin	40-49	AKT serine/threonine kinase 1	Rattus norvegicus	158-161
28225806-12	2017	These results demonstrated that dietary capsaicin appears to prevent the hyperphosphorylation of AD-associated tau protein by increasing the activity of PI3K/AKT and inhibiting GSK-3beta in hippocampus of T2D rats, which supported that dietary capsaicin might have a potential use for the prevention of AD in T2D.	Capsaicin	40-49	glycogen synthase kinase 3 alpha	Rattus norvegicus	177-186
27710012-8	2017	The capsaicin-induced effects were inhibited by the TRPV1 antagonist capsazepine, amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonists CNQX, NBQX, perampanel, and riluzole, a drug that inhibits glutamate release and increases glutamate uptake.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-57
27710012-10	2017	To summarize, capsaicin-induced apneas and seizure-like behaviors are mediated via TRPV1 activation acting at lung afferents, spinal cord-ascending tracts, and medullary structures (including nucleus tractus solitarius).	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
28281854-0	2017	Capsaicin pretreatment reversed pulmonary arterial hypertension by alleviating inflammation via p38MAPK pathway.	Capsaicin	0-9	mitogen activated protein kinase 14	Rattus norvegicus	96-103
27818188-11	2017	BDNF enhanced, rather than attenuated, capsaicin-induced EMR and ERK/pERK expression.	Capsaicin	39-48	brain-derived neurotrophic factor	Rattus norvegicus	0-4
27818188-11	2017	BDNF enhanced, rather than attenuated, capsaicin-induced EMR and ERK/pERK expression.	Capsaicin	39-48	Eph receptor B1	Rattus norvegicus	65-68
28352332-6	2017	Electrophysiological analysis revealed that the butanol fraction inhibited capsaicin-induced TRPV1 (84+-8% at -60 mV/86+-1% at 100 mV at 100 microg/ml) and ORAI1 (87+-2% at -120 mV at 100 microg/ml) currents.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-98
28281854-11	2017	Phosphorylated-p38 (p-p38) MAPK was up-regulated, which was partially reversed by capsaicin pretreatment.	Capsaicin	82-91	mitogen activated protein kinase 14	Rattus norvegicus	15-18
28352332-6	2017	Electrophysiological analysis revealed that the butanol fraction inhibited capsaicin-induced TRPV1 (84+-8% at -60 mV/86+-1% at 100 mV at 100 microg/ml) and ORAI1 (87+-2% at -120 mV at 100 microg/ml) currents.	Capsaicin	75-84	ORAI calcium release-activated calcium modulator 1	Homo sapiens	156-161
28281854-11	2017	Phosphorylated-p38 (p-p38) MAPK was up-regulated, which was partially reversed by capsaicin pretreatment.	Capsaicin	82-91	mitogen activated protein kinase 14	Rattus norvegicus	22-25
28281854-13	2017	Inhibition of p38MAPK provided the same benefits with capsaicin pretreatment, whereas it failed to provide additional improvement in the presence of capsaicin.	Capsaicin	54-63	mitogen activated protein kinase 14	Rattus norvegicus	14-21
28281854-14	2017	Besides, p38MAPK activator abolished the effects of capsaicin pretreatment on PAH, suggesting a key role of p38MPAK pathway in the effects of capsaicin reversing PAH.	Capsaicin	52-61	mitogen activated protein kinase 14	Rattus norvegicus	9-16
28281854-14	2017	Besides, p38MAPK activator abolished the effects of capsaicin pretreatment on PAH, suggesting a key role of p38MPAK pathway in the effects of capsaicin reversing PAH.	Capsaicin	52-61	mitogen activated protein kinase 14	Rattus norvegicus	9-12
28281854-14	2017	Besides, p38MAPK activator abolished the effects of capsaicin pretreatment on PAH, suggesting a key role of p38MPAK pathway in the effects of capsaicin reversing PAH.	Capsaicin	142-151	mitogen activated protein kinase 14	Rattus norvegicus	9-16
28281854-14	2017	Besides, p38MAPK activator abolished the effects of capsaicin pretreatment on PAH, suggesting a key role of p38MPAK pathway in the effects of capsaicin reversing PAH.	Capsaicin	142-151	mitogen activated protein kinase 14	Rattus norvegicus	9-12
28281854-15	2017	CONCLUSIONS: Capsaicin pretreatment reversed PAH by alleviating inflammation via p38MAPK pathway.	Capsaicin	13-22	mitogen activated protein kinase 14	Rattus norvegicus	81-88
27900462-3	2017	We examined effects of capsaicin, a specific agonist of TRPV1 channels, on respiratory rhythm generation in brainstem-spinal cord preparation from newborn rats.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
27055401-5	2017	RESULTS: The intracellular free calcium ion concentration and current densities increased with TRPV1 channel activator capsaicin (0.01 mM), but they decreased with the TRPV1 blocker capsazepine (0.1 mM), Se, cisplatin, and Se + cisplatin incubations.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
27168163-3	2017	Transient receptor potential vanilloid 1 (TRPV1) on cell membrane is activated by TRPV1 agonist capsaicin resulting in an opening of the channel for calcium influx, which is linked with neurosensory sensations characterized by itching, burning and stinging of skin.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
27168163-3	2017	Transient receptor potential vanilloid 1 (TRPV1) on cell membrane is activated by TRPV1 agonist capsaicin resulting in an opening of the channel for calcium influx, which is linked with neurosensory sensations characterized by itching, burning and stinging of skin.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
27168163-3	2017	Transient receptor potential vanilloid 1 (TRPV1) on cell membrane is activated by TRPV1 agonist capsaicin resulting in an opening of the channel for calcium influx, which is linked with neurosensory sensations characterized by itching, burning and stinging of skin.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
27900462-14	2017	The effects of capsaicin were partially blocked by TRPV1 antagonists but could be also induced at least partially via the non-specific action.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
29926601-4	2017	Rats were given capsaicin (50 mg/kg d) by subcutaneous injections 4 days before to deplete endogenous CGRP.	Capsaicin	16-25	calcitonin-related polypeptide alpha	Rattus norvegicus	102-106
27991776-0	2017	Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-beta1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation.	Capsaicin	0-9	peroxisome proliferator-activated receptor gamma	Rattus norvegicus	109-157
28076819-3	2017	Our BRET study also confirmed that: (1) capsaicin and heat promoted distinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca2+-bound CaM but not Ca2+-free CaM were preassociated in resting live cells, while capsaicin activation induced both the formation of more TRPV1/CaM complexes and conformational changes.	Capsaicin	40-49	calmodulin 1	Homo sapiens	165-168
28076819-3	2017	Our BRET study also confirmed that: (1) capsaicin and heat promoted distinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca2+-bound CaM but not Ca2+-free CaM were preassociated in resting live cells, while capsaicin activation induced both the formation of more TRPV1/CaM complexes and conformational changes.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	295-300
28076819-3	2017	Our BRET study also confirmed that: (1) capsaicin and heat promoted distinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca2+-bound CaM but not Ca2+-free CaM were preassociated in resting live cells, while capsaicin activation induced both the formation of more TRPV1/CaM complexes and conformational changes.	Capsaicin	239-248	transient receptor potential cation channel subfamily V member 1	Homo sapiens	144-149
28076819-3	2017	Our BRET study also confirmed that: (1) capsaicin and heat promoted distinct transitions, independently coupled to channel gating, and that (2) TRPV1 and Ca2+-bound CaM but not Ca2+-free CaM were preassociated in resting live cells, while capsaicin activation induced both the formation of more TRPV1/CaM complexes and conformational changes.	Capsaicin	239-248	calmodulin 1	Homo sapiens	165-168
27991776-0	2017	Capsaicin Inhibits Dimethylnitrosamine-Induced Hepatic Fibrosis by Inhibiting the TGF-beta1/Smad Pathway via Peroxisome Proliferator-Activated Receptor Gamma Activation.	Capsaicin	0-9	transforming growth factor, beta 1	Rattus norvegicus	82-91
27196129-7	2017	Furthermore, the anti-invasive activity of arvanil, olvanil and capsaicin was mediated by the AMPK pathway.	Capsaicin	64-73	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	94-98
27196129-8	2017	Depletion of AMPK levels by siRNA methodology abrogated the anti-invasive activity of arvanil, olvanil and capsaicin.	Capsaicin	107-116	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	13-17
28461977-0	2017	Voltage-Dependent Interaction of Capsaicine and Protons on TRPV1-Receptors.	Capsaicin	33-43	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	59-64
28461977-1	2017	The interaction of TRPV1-receptors agonists (capsaicin and protons) has been studied on cultured CHO cells transfected by TRPV1-receptors.	Capsaicin	45-54	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	19-24
28461977-3	2017	The TRPV1-mediated currents induced by the pH and Capsaicin demonstrated arithmetical summation at potentials between 40--40 mV, while they were potentiated at potentials below -40 mV.	Capsaicin	50-59	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	4-9
28294062-0	2017	Warming Up to New Possibilities with the Capsaicin Receptor TRPV1: mTOR, AMPK, and Erythropoietin.	Capsaicin	41-50	AMP-activated protein kinase alpha subunit	Drosophila melanogaster	73-77
28690256-1	2017	A sensitive capsaicin sensor was constructed based on a poly(sodium 4-styrenesulfonate) functionalized graphite modified screen printed electrode (PSS-Grp/SPE) in this study.	Capsaicin	12-21	gastrin releasing peptide	Homo sapiens	151-154
28690256-4	2017	The electrochemical performance of PSS-Grp in a 50 muM capsaicin solution presented a current density of 33 muA cm-2, which was much higher than the PDDA-Grp of 1.5 muA cm-2.	Capsaicin	55-64	gastrin releasing peptide	Homo sapiens	39-42
28690256-5	2017	Our study showed that capsaicin could interact better with strong negative charges on the PSS-Grp/SPE surface to give a higher electrochemical response.	Capsaicin	22-31	gastrin releasing peptide	Homo sapiens	94-97
28690256-6	2017	The direct electrochemical sensing of capsaicin was achieved at PSS-Grp/SPE using differential pulse stripping voltammetry (DPSV) under the optimized conditions.	Capsaicin	38-47	gastrin releasing peptide	Homo sapiens	68-71
29238714-5	2017	Besides, NsAchE-negative but capsaicin-sensitive subbasal nerve (leash) fibers formed thick mesh-like structure showing close interconnections and exhibit both isolectin B4- and transient receptor potential vanilloid channel 1- (TRPV1-) positive.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	229-234
27792844-0	2017	Hydrogen peroxide preferentially activates capsaicin-sensitive high threshold afferents via TRPA1 channels in the guinea pig bladder.	Capsaicin	43-52	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	92-97
27792844-5	2017	The TRPV1 channel agonist, capsaicin, excited 86% of high threshold afferents.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	4-9
27792844-6	2017	The TRPA1 channel agonist, allyl isothiocyanate and the TRPM8 channel agonist, icilin activated 72% and 47% of capsaicin-sensitive high threshold afferents respectively.	Capsaicin	111-120	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	4-9
27792844-6	2017	The TRPA1 channel agonist, allyl isothiocyanate and the TRPM8 channel agonist, icilin activated 72% and 47% of capsaicin-sensitive high threshold afferents respectively.	Capsaicin	111-120	transient receptor potential cation channel subfamily M member 8	Cavia porcellus	56-61
27792844-10	2017	The data suggest that the TRPA1 channels located on these capsaicin-sensitive afferent fibres are probable targets of ROS released during oxidative stress.	Capsaicin	58-67	transient receptor potential cation channel subfamily A member 1	Cavia porcellus	26-31
26935063-6	2017	The TRPM2 channel antagonist, N-(p-amylcinnamoyl)anthranilic acid (ACA), inhibited cumene hydroperoxide and ADP-ribose-induced TRPM2 currents in the neurons, and capsazepine (CPZ) inhibited capsaicin-induced TRPV1 currents.	Capsaicin	190-199	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	4-9
28848196-9	2017	In addition, capsaicin (a TRPV1 agonist) evokes a greater increase in the amplitude of AITC-currents in DRG neurons of ligated limbs than that in control limbs.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
27821307-6	2017	To prove sensing functionality of the tissue, we use topical applications of capsaicin, an agonist of transient receptor protein-vanilloid 1 (TRPV1) channel, and quantify calcium currents resulting from variations of Ca++ concentration in DRG neurons innervating our model.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-140
27821307-6	2017	To prove sensing functionality of the tissue, we use topical applications of capsaicin, an agonist of transient receptor protein-vanilloid 1 (TRPV1) channel, and quantify calcium currents resulting from variations of Ca++ concentration in DRG neurons innervating our model.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	142-147
28637949-4	2017	Both mammalian and chicken TRPV1 (cTRPV1) are activated by heat and acid, but unlike its mammalian counterpart, cTRPV1 is only faintly activated by capsaicin.	Capsaicin	148-157	transient receptor potential cation channel subfamily V member 1	Gallus gallus	27-32
28637949-5	2017	This difference is due to the 8 chicken-specific amino acid residues around transmembrane 3, which is the main site of capsaicin-binding in rat TRPV1.	Capsaicin	119-128	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-149
28637949-6	2017	Moreover, AITC-induced activation of mouse TRPV1 (mTRPV1) is largely dependent on S513, a residue that is involved in capsaicin-binding.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
28637949-6	2017	Moreover, AITC-induced activation of mouse TRPV1 (mTRPV1) is largely dependent on S513, a residue that is involved in capsaicin-binding.	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	50-56
28637949-7	2017	Thus, we hypothesized that the increase of carbohydrate oxidation by AITC in mammals is induced by the binding of AITC to the capsaicin-binding site of TRPV1.	Capsaicin	126-135	transient receptor potential cation channel subfamily V member 1	Gallus gallus	152-157
28637949-8	2017	In this study, we performed a comparative study using chickens and mice, since chickens are thought to partly lack the capsaicin-binding site of TRPV1.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Gallus gallus	145-150
27821437-5	2017	CAP and PIP were significantly more potent inhibitors of CYP1A2 (IC50 2.14 +- 0.22 microM and 14.19 +- 4.15 microM, respectively) than CUR (IC50 &gt; 100 microM), while all three SCs exhibited weak activity toward CYP2D6 (IC50 95.42 +- 12.09 microM for CUR, 99.99 +- 5.88 microM for CAP, and 110.40 +- 3.23 microM for PIP).	Capsaicin	0-3	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	57-63
27821437-5	2017	CAP and PIP were significantly more potent inhibitors of CYP1A2 (IC50 2.14 +- 0.22 microM and 14.19 +- 4.15 microM, respectively) than CUR (IC50 &gt; 100 microM), while all three SCs exhibited weak activity toward CYP2D6 (IC50 95.42 +- 12.09 microM for CUR, 99.99 +- 5.88 microM for CAP, and 110.40 +- 3.23 microM for PIP).	Capsaicin	0-3	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	214-220
28671132-3	2017	Capsaicin, a specific agonist of the transient receptor potential vanilloid 1 (TRPV1), has been proven to ameliorate stress-induced AD-like pathological and cognitive impairments, but it is unclear whether TRPV1 activation can affect cognitive and synaptic functions in Abeta-induced mouse model of AD.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	37-77
28123347-6	2017	Moreover, FT-A inhibited IL-8 and PGE2 secretions, and calcium influx in the HEK 293T-TRPV1 cells after stimulated with capsaicin, the specific TRPV1 agonist.	Capsaicin	120-129	farnesyltransferase, CAAX box, alpha	Mus musculus	10-14
28123347-6	2017	Moreover, FT-A inhibited IL-8 and PGE2 secretions, and calcium influx in the HEK 293T-TRPV1 cells after stimulated with capsaicin, the specific TRPV1 agonist.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
28123347-6	2017	Moreover, FT-A inhibited IL-8 and PGE2 secretions, and calcium influx in the HEK 293T-TRPV1 cells after stimulated with capsaicin, the specific TRPV1 agonist.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	144-149
28319947-7	2017	Salivary SP levels were significantly increased after capsaicin administration compared with placebo in the effective group.	Capsaicin	54-63	tachykinin precursor 1	Homo sapiens	9-11
28319947-10	2017	CONCLUSION: Elevated salivary SP concentrations stimulated by capsaicin greatly improve the safety and efficacy of swallowing, and shorten the swallow response in older patients with OD.	Capsaicin	62-71	tachykinin precursor 1	Homo sapiens	30-32
28671132-3	2017	Capsaicin, a specific agonist of the transient receptor potential vanilloid 1 (TRPV1), has been proven to ameliorate stress-induced AD-like pathological and cognitive impairments, but it is unclear whether TRPV1 activation can affect cognitive and synaptic functions in Abeta-induced mouse model of AD.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	79-84
28671132-3	2017	Capsaicin, a specific agonist of the transient receptor potential vanilloid 1 (TRPV1), has been proven to ameliorate stress-induced AD-like pathological and cognitive impairments, but it is unclear whether TRPV1 activation can affect cognitive and synaptic functions in Abeta-induced mouse model of AD.	Capsaicin	0-9	amyloid beta (A4) precursor protein	Mus musculus	270-275
28671132-12	2017	These results indicate that TRPV1 activation by capsaicin rescues cognitive deficit in the Abeta42-induced mouse model of AD both structurely and functionally.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-33
27901346-0	2017	Capsaicin Modulates the Immune Cross Talk Between Human Mononuclears and Cells from Two Colon Carcinoma Lines.	Capsaicin	0-9	bone morphogenetic protein receptor type 2	Homo sapiens	37-41
27631428-12	2017	These results suggest that EHE suppresses capsaicin-induced paw licking by regulating TRPV1 activity.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
28879245-6	2017	Capsaicin is the primary agonist for TRPV1 and has been used previously in relatively low doses (0.025% to 0.075%) as a therapeutic for a variety of pain disorders, including postherpetic neuralgia and osteoarthritis; however, analgesic efficacy remains equivocal.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
30613832-10	2017	In diabetic mice, intraplantar injection of capsaicin, a TRPV1 agonist-induced nocifensive behavior but the severity of this behavior was significantly lower when co-administered with menthol, a TRPM8 agonist.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	57-62
30613832-10	2017	In diabetic mice, intraplantar injection of capsaicin, a TRPV1 agonist-induced nocifensive behavior but the severity of this behavior was significantly lower when co-administered with menthol, a TRPM8 agonist.	Capsaicin	44-53	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	195-200
26947234-9	2017	In addition, capsaicin stimulated the formation of reticular mitochondria, augmented mitochondrial membrane potential, increased adenosine triphosphate production, and upregulated Mfn2.	Capsaicin	13-22	mitofusin 2	Mus musculus	180-184
26947234-12	2017	Moreover, Mfn2 siRNA also attenuated capsaicin-induced enhancement of endothelial recovery and suppression of neointimal hyperplasia in WT mice.	Capsaicin	37-46	mitofusin 2	Mus musculus	10-14
26947234-13	2017	CONCLUSIONS: Activation of TRPV1 with capsaicin attenuates neointimal formation by accelerating re-endothelialization through upregulation of Mfn2.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
26947234-13	2017	CONCLUSIONS: Activation of TRPV1 with capsaicin attenuates neointimal formation by accelerating re-endothelialization through upregulation of Mfn2.	Capsaicin	38-47	mitofusin 2	Mus musculus	142-146
29435095-0	2017	Capsaicin Protects Cardiomyocytes against Anoxia/Reoxygenation Injury via Preventing Mitochondrial Dysfunction Mediated by SIRT1.	Capsaicin	0-9	sirtuin 1	Rattus norvegicus	123-128
29163755-6	2017	Moreover, drugs (fenofibrate and sitagliptin) and several vegetable compounds (extracts from Brassicaceae, berberine, curcumin, and capsaicin) are able to induce UCP2 expression level and to exert beneficial effects on the occurrence of vascular damage.	Capsaicin	132-141	uncoupling protein 2	Homo sapiens	162-166
27627464-8	2016	This in turn decreases rate and amplitude of TRPV1-mediated cytosolic calcium, which inhibits capsaicin-induced inward current and neuronal firing.	Capsaicin	94-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-50
27992447-13	2016	In addition, sperm cells were able to migrate toward a gradient of capsaicin, a specific agonist of TRPV1, whilst capsazepine, a specific agonist of TRPV1, blocked this effect.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
27916453-7	2016	Furthermore, capsaicin-induced spontaneous pain, inward currents in DRG neurons, and synaptic currents in spinal cord neurons are all reduced after Shank3 haploinsufficiency.	Capsaicin	13-22	SH3 and multiple ankyrin repeat domains 3	Mus musculus	148-154
28008282-5	2016	Activation of TRPV1 by its ligand capsaicin was associated with the growth inhibition of some cancer cell types; however, the signaling components involved are complex.	Capsaicin	34-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
28008282-6	2016	In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	34-39
28008282-6	2016	In this study, stimulation by the TRPV1 agonist, capsaicin, of SUM149PT cells, a model system for the most aggressive breast cancer subtype, triple-negative breast cancer, led to intracellular calcium signals that were diminished by the specific TRPV1 antagonist, capsazepin.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	246-251
28008282-7	2016	Activation of TRPV1 by capsaicin caused significant inhibition of cancer cell growth and induced apoptosis and necrosis.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
27627464-10	2016	Finally, NCLX controls capsaicin-induced cell death, by supporting massive mitochondrial Ca2+ shuttling.	Capsaicin	23-32	solute carrier family 8 member B1	Homo sapiens	9-13
27614181-14	2016	In addition, treatment with a high dose of capsaicin in newborn rats, which induces degeneration of TRPV1-expressing sensory neurons, abolished both capsaicin and captopril-induced plasma extravasation in artificially ventilated rats.	Capsaicin	43-52	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	100-105
27682362-10	2016	Specifically, complete rescue of capsaicin-mediated activation of TRPV1 was obtained following mutation of pore Cysteine 621.	Capsaicin	33-42	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	66-71
28195064-3	2016	Therefore, the aims of this study were to evaluate the effects of epinephrine and norepinephrine on TRPV1 desensitization induced by repeated applications of capsaicin and to assess what would be the involvement of the major alpha1, alpha2 and beta adrenergic receptor subtypes.	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
28003842-0	2016	Biomimetic proopiomelanocortin suppresses capsaicin-induced sensory irritation in humans.	Capsaicin	42-51	proopiomelanocortin	Homo sapiens	11-30
28003842-3	2016	This study was aimed to assess the inhibitory effect of a biomimetic lipopeptide derived from proopiomelanocortin (bPOMC) on capsaicin-induced sensory irritation in human volunteers and also to compare its protective effect with that of the well-known anti irritant strontium chloride.	Capsaicin	125-134	proopiomelanocortin	Homo sapiens	94-113
27556497-5	2016	Sensory CGRP depletion by capsaicin exacerbated bleomycin-induced pulmonary fibrosis in rats, as shown by a significant disturbed alveolar structure, marked thickening of the interalveolar septa and dense interstitial infiltration by inflammatory cells and fibroblasts, accompanied with increased expression of TGF-beta1, eIF3a, phosphorylated ERK1/2, alpha-SMA, collagen I, and collagen III.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	8-12
27556497-5	2016	Sensory CGRP depletion by capsaicin exacerbated bleomycin-induced pulmonary fibrosis in rats, as shown by a significant disturbed alveolar structure, marked thickening of the interalveolar septa and dense interstitial infiltration by inflammatory cells and fibroblasts, accompanied with increased expression of TGF-beta1, eIF3a, phosphorylated ERK1/2, alpha-SMA, collagen I, and collagen III.	Capsaicin	26-35	transforming growth factor, beta 1	Rattus norvegicus	311-320
27556497-5	2016	Sensory CGRP depletion by capsaicin exacerbated bleomycin-induced pulmonary fibrosis in rats, as shown by a significant disturbed alveolar structure, marked thickening of the interalveolar septa and dense interstitial infiltration by inflammatory cells and fibroblasts, accompanied with increased expression of TGF-beta1, eIF3a, phosphorylated ERK1/2, alpha-SMA, collagen I, and collagen III.	Capsaicin	26-35	eukaryotic translation initiation factor 3, subunit J	Rattus norvegicus	322-327
27556497-5	2016	Sensory CGRP depletion by capsaicin exacerbated bleomycin-induced pulmonary fibrosis in rats, as shown by a significant disturbed alveolar structure, marked thickening of the interalveolar septa and dense interstitial infiltration by inflammatory cells and fibroblasts, accompanied with increased expression of TGF-beta1, eIF3a, phosphorylated ERK1/2, alpha-SMA, collagen I, and collagen III.	Capsaicin	26-35	mitogen activated protein kinase 3	Rattus norvegicus	344-350
27633915-0	2016	A novel form of capsaicin-modified amygdala LTD mediated by TRPM1.	Capsaicin	16-25	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	60-65
27633915-1	2016	Recently we have shown that capsaicin attenuates the strength of LTP in the lateral amygdala (LA) and demonstrated that this effect is mediated by the transient receptor potential (TRP) channel TRPV1.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	194-199
27633915-2	2016	Here we further show that capsaicin, which is thought to act primarily through TRPV1, modifies long term depression (LTD) in the LA.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	79-84
27633915-5	2016	Using pharmacology and TRPM1-/- mice, our electrophysiological data indicate that capsaicin-induced activation of TRPM1 channels contribute to the induction of LA-LTD.	Capsaicin	82-91	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	23-28
27633915-5	2016	Using pharmacology and TRPM1-/- mice, our electrophysiological data indicate that capsaicin-induced activation of TRPM1 channels contribute to the induction of LA-LTD.	Capsaicin	82-91	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	114-119
27633915-6	2016	Whereas LA-LTD in general depends on the acitvation of NMDA receptors- and group II metabotropic glutamate receptors (mGluR), the modifying effect of capsaicin on LA-LTD via TRPM1 appears to be specifically mediated by group I mGluRs and in interaction with another member of the TRP family, TRPC5.	Capsaicin	150-159	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	174-179
27633915-6	2016	Whereas LA-LTD in general depends on the acitvation of NMDA receptors- and group II metabotropic glutamate receptors (mGluR), the modifying effect of capsaicin on LA-LTD via TRPM1 appears to be specifically mediated by group I mGluRs and in interaction with another member of the TRP family, TRPC5.	Capsaicin	150-159	transient receptor potential cation channel, subfamily C, member 5	Mus musculus	292-297
27614181-14	2016	In addition, treatment with a high dose of capsaicin in newborn rats, which induces degeneration of TRPV1-expressing sensory neurons, abolished both capsaicin and captopril-induced plasma extravasation in artificially ventilated rats.	Capsaicin	149-158	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	100-105
27886264-0	2016	Sigma-1 Receptor Agonism Promotes Mechanical Allodynia After Priming the Nociceptive System with Capsaicin.	Capsaicin	97-106	sigma non-opioid intracellular receptor 1	Mus musculus	0-16
27758864-2	2016	We hypothesized that polymorphic variants of transient receptor potential vanilloid-1 (TRPV1) would be uniquely responsive to insoluble coal fly ash compared with the prototypical soluble agonist capsaicin.	Capsaicin	196-205	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
27758864-4	2016	The TRPV1-I315M and -T469I variants were more responsive to capsaicin and coal fly ash.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
27872485-7	2016	DEX effectively reversed capsaicin and cumene hydroperoxide/ADP-ribose-induced TRPV1 and TRPM2 densities and cytosolic calcium ion accumulation in the neurons, respectively.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
27872485-7	2016	DEX effectively reversed capsaicin and cumene hydroperoxide/ADP-ribose-induced TRPV1 and TRPM2 densities and cytosolic calcium ion accumulation in the neurons, respectively.	Capsaicin	25-34	transient receptor potential cation channel, subfamily M, member 2	Rattus norvegicus	89-94
27715462-0	2016	Capsaicin reactivates hMOF in gastric cancer cells and induces cell growth inhibition.	Capsaicin	0-9	lysine acetyltransferase 8	Homo sapiens	22-26
27654891-9	2016	Furthermore, capsaicin triggered arteriole constriction that was rapidly reversed by the TRPV1 antagonist, BCTC.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	89-94
27827430-5	2016	TRPV1-mediated membrane currents evoked by protons, capsaicin or heat are inhibited by LA at concentrations ranging from 3 muM to 100 mM.	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
27722942-0	2016	Quantitative characterization of capsaicin-induced TRPV1 ion channel activation in HEK293 cells by impedance spectroscopy.	Capsaicin	33-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
27722942-6	2016	TRPV1 channel activation by capsaicin resulted in a reproducible impedance decrease.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
27715462-6	2016	Further studies found that hMOF, a major histone acetyltranferase for H4K16, is central to CAP-induced epigenetic changes.	Capsaicin	91-94	lysine acetyltransferase 8	Homo sapiens	27-31
27748914-5	2016	The apoptosis-inducing effects of Cap and DHC in U251 cells were associated with the generation of reactive oxygen species, increased Ca2+ concentrations, mitochondrial depolarization, release of cytochrome c into the cytosol and activation of caspase-9 and -3.	Capsaicin	34-37	cytochrome c, somatic	Homo sapiens	196-208
28076465-0	2016	The effect of capsaicin on expression patterns of CGRP in trigeminal ganglion and trigeminal nucleus caudalis following experimental tooth movement in rats.	Capsaicin	14-23	calcitonin-related polypeptide alpha	Rattus norvegicus	50-54
28076465-1	2016	Objectives: The aim of this study was to explore the effect of capsaicin on expression patterns of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) and trigeminal subnucleus caudalis (Vc) following experimental tooth movement.	Capsaicin	63-72	calcitonin-related polypeptide alpha	Rattus norvegicus	99-130
28076465-1	2016	Objectives: The aim of this study was to explore the effect of capsaicin on expression patterns of calcitonin gene-related peptide (CGRP) in the trigeminal ganglion (TG) and trigeminal subnucleus caudalis (Vc) following experimental tooth movement.	Capsaicin	63-72	calcitonin-related polypeptide alpha	Rattus norvegicus	132-136
28076465-9	2016	However, both small-dose and large-dose capsaicin could decrease CGRP expression in TG and Vc at 1 d and 3 d following experimental tooth movement, as compared with the saline + force group.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
28076465-10	2016	Conclusions: These results suggest that capsaicin could regulate CGRP expression in TG and Vc following experimental tooth movement in rats.	Capsaicin	40-49	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
27520401-8	2016	Intra-DLPAG administration of either the TRPV1 agonist capsaicin, or the TRPV1 antagonist 5"-Iodoresiniferatoxin (5"-IRTX), significantly increased formalin-evoked nociceptive behaviour in SD rats, but not in WKY rats.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	41-46
27520401-9	2016	The effects of capsaicin were likely due to TRPV1 desensitisation, given their similarity to the effects of 5"-IRTX.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	44-49
27809268-3	2016	Capsaicin selectively activates TRPV1, a Ca2+-permeable cationic ion channel that is enriched in the terminals of certain nociceptors.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
26526845-8	2016	At all developmental stages, TRPV1 activation with the selective agonist capsaicin increases glutamate release in the presence of tetrodotoxin, which blocks action potential-dependent and polysynaptic neurotransmission, indicating that functional TRPV1 fibers innervate SDCN neurons directly.	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-34
26526845-8	2016	At all developmental stages, TRPV1 activation with the selective agonist capsaicin increases glutamate release in the presence of tetrodotoxin, which blocks action potential-dependent and polysynaptic neurotransmission, indicating that functional TRPV1 fibers innervate SDCN neurons directly.	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	247-252
26526845-9	2016	Capsaicin-induced presynaptic glutamate release onto SDCN neurons depends on external Ca2+ influx through TRPV1 channels; voltage-dependent calcium channels had a slighter impact.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	106-111
26526845-10	2016	In contrast, capsaicin blocked C fiber-evoked synaptic transmission, indicating that TRPV1 activation has opposite effects on spontaneous asynchronous and action potential-dependent synchronous glutamate release.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	85-90
26526845-12	2016	The opposite action of capsaicin on asynchronous and synchronous glutamate release should be taken into account when TRPV1 channels are considered as therapeutic targets.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	117-122
27748914-5	2016	The apoptosis-inducing effects of Cap and DHC in U251 cells were associated with the generation of reactive oxygen species, increased Ca2+ concentrations, mitochondrial depolarization, release of cytochrome c into the cytosol and activation of caspase-9 and -3.	Capsaicin	34-37	caspase 9	Homo sapiens	244-260
27490714-7	2016	RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only.	Capsaicin	33-42	tumor necrosis factor	Homo sapiens	82-90
27511837-6	2016	In all neurons investigated, 5HT potentiated capsaicin-evoked currents through TRPV1 channels, an effect that was attenuated by antagonists at 5HT2A (4 F 4 PP), 5HT2B (SB 204741), as well as 5HT2C (RS 102221) receptors.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
27511837-6	2016	In all neurons investigated, 5HT potentiated capsaicin-evoked currents through TRPV1 channels, an effect that was attenuated by antagonists at 5HT2A (4 F 4 PP), 5HT2B (SB 204741), as well as 5HT2C (RS 102221) receptors.	Capsaicin	45-54	5-hydroxytryptamine receptor 2A	Rattus norvegicus	143-148
27511837-6	2016	In all neurons investigated, 5HT potentiated capsaicin-evoked currents through TRPV1 channels, an effect that was attenuated by antagonists at 5HT2A (4 F 4 PP), 5HT2B (SB 204741), as well as 5HT2C (RS 102221) receptors.	Capsaicin	45-54	5-hydroxytryptamine receptor 2B	Rattus norvegicus	161-166
27511837-6	2016	In all neurons investigated, 5HT potentiated capsaicin-evoked currents through TRPV1 channels, an effect that was attenuated by antagonists at 5HT2A (4 F 4 PP), 5HT2B (SB 204741), as well as 5HT2C (RS 102221) receptors.	Capsaicin	45-54	5-hydroxytryptamine receptor 2C	Rattus norvegicus	191-196
27490714-7	2016	RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only.	Capsaicin	33-42	interleukin 6	Homo sapiens	92-96
27490714-7	2016	RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only.	Capsaicin	33-42	C-X-C motif chemokine ligand 8	Homo sapiens	98-102
27490714-7	2016	RESULTS: Following intramuscular capsaicin injection, pro-inflammatory cytokines [TNFalpha, IL-6, IL-8] significantly increased (percent rise from baseline) in both groups, whereas IL-1beta significantly increased in the PTSD group only.	Capsaicin	33-42	interleukin 1 beta	Homo sapiens	181-189
27734949-3	2016	This deletion not only inactivates the CTNS gene but also extends into the non-coding region upstream of the start codon of the TRPV1 gene, encoding the capsaicin- and heat-sensitive ion channel TRPV1.	Capsaicin	153-162	cystinosin, lysosomal cystine transporter	Homo sapiens	39-43
27775662-0	2016	Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways.	Capsaicin	0-9	forkhead box O3	Mus musculus	118-124
27775662-1	2016	Capsaicin (CAP), a highly selective agonist for transient receptor potential vanilloid type 1 (TRPV1), has been widely reported to exhibit anti-oxidant, anti-inflammation and anticancer activities.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	48-93
27729033-0	2016	Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma.	Capsaicin	0-9	mitogen-activated protein kinase 14	Homo sapiens	69-72
27729033-0	2016	Capsaicin mediates caspases activation and induces apoptosis through P38 and JNK MAPK pathways in human renal carcinoma.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	77-80
27775662-1	2016	Capsaicin (CAP), a highly selective agonist for transient receptor potential vanilloid type 1 (TRPV1), has been widely reported to exhibit anti-oxidant, anti-inflammation and anticancer activities.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
27775662-1	2016	Capsaicin (CAP), a highly selective agonist for transient receptor potential vanilloid type 1 (TRPV1), has been widely reported to exhibit anti-oxidant, anti-inflammation and anticancer activities.	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	48-93
27775662-1	2016	Capsaicin (CAP), a highly selective agonist for transient receptor potential vanilloid type 1 (TRPV1), has been widely reported to exhibit anti-oxidant, anti-inflammation and anticancer activities.	Capsaicin	11-14	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
27775662-11	2016	Thus, our results suggested that CAP could inhibit viability and tumorigenesis of BCa possibly via FOXO3a-mediated pathways.	Capsaicin	33-36	forkhead box O3	Mus musculus	99-105
27563736-10	2016	Orexin significantly potentiated the mentioned effects of CAP, whereas SB-334867 (40, 80 nM/rat) exerted a significant inhibitory effect on CAP-induced anxiety.	Capsaicin	58-61	hypocretin neuropeptide precursor	Rattus norvegicus	0-6
28246465-8	2016	Based on the interaction of Cardamoninand capsaicin it was found to have an influencing role against the transcription factor like NF-kappaB andPPAR-gamma.	Capsaicin	42-51	nuclear factor kappa B subunit 1	Homo sapiens	131-140
27729033-3	2016	Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-132
27729033-3	2016	Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	134-139
27734949-3	2016	This deletion not only inactivates the CTNS gene but also extends into the non-coding region upstream of the start codon of the TRPV1 gene, encoding the capsaicin- and heat-sensitive ion channel TRPV1.	Capsaicin	153-162	transient receptor potential cation channel subfamily V member 1	Homo sapiens	128-133
27729033-3	2016	Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-132
27729033-3	2016	Capsaicin (CPS), a natural active ingredient of green and red peppers, and a ligand of transient receptor potential vanilloid type 1 (TRPV1), has been showed potential in suppression of tumorigenesis of several cancers.	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	134-139
27734949-3	2016	This deletion not only inactivates the CTNS gene but also extends into the non-coding region upstream of the start codon of the TRPV1 gene, encoding the capsaicin- and heat-sensitive ion channel TRPV1.	Capsaicin	153-162	transient receptor potential cation channel subfamily V member 1	Homo sapiens	195-200
27729033-10	2016	Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9.	Capsaicin	9-12	mitogen-activated protein kinase 14	Homo sapiens	33-36
26892397-6	2016	Using isolated mouse satellite cells (i.e., myoblasts), we observed that activation of TRPV1 by its agonist capsaicin (CAP) augmented myogenin protein levels.	Capsaicin	108-117	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	87-92
27729033-10	2016	Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9.	Capsaicin	9-12	mitogen-activated protein kinase 8	Homo sapiens	41-44
27729033-10	2016	Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9.	Capsaicin	9-12	caspase 3	Homo sapiens	165-186
27729033-10	2016	Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9.	Capsaicin	115-118	mitogen-activated protein kinase 14	Homo sapiens	64-67
27729033-10	2016	Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9.	Capsaicin	115-118	mitogen-activated protein kinase 8	Homo sapiens	72-75
27729033-10	2016	Besides, CPS-treatment activated P38 and JNK MAPK pathways, yet P38 and JNK inhibitors afforded protection against CPS-induced apoptosis by abolishing activation of caspase-3, -8, and -9.	Capsaicin	115-118	caspase 3	Homo sapiens	165-186
27250983-2	2016	Other studies showed that ATP activates the capsaicin-sensitive TRPV1 channel via P2Y receptors.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-69
27732851-3	2016	The sensitization of capsaicin-sensitive TRPV1 ion channels is necessary for NGF-induced hyperalgesia, but naked mole-rats have fully functional TRPV1 channels.	Capsaicin	21-30	transient receptor potential cation channel subfamily V member 1	Heterocephalus glaber	41-46
27732851-3	2016	The sensitization of capsaicin-sensitive TRPV1 ion channels is necessary for NGF-induced hyperalgesia, but naked mole-rats have fully functional TRPV1 channels.	Capsaicin	21-30	beta-nerve growth factor	Heterocephalus glaber	77-80
26988467-1	2016	BACKGROUND: At high concentration, the TRPV-1 agonist capsaicin de-sensitizes nociceptors and reduces the intra-epidermal nerve density.	Capsaicin	54-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	39-45
26892397-6	2016	Using isolated mouse satellite cells (i.e., myoblasts), we observed that activation of TRPV1 by its agonist capsaicin (CAP) augmented myogenin protein levels.	Capsaicin	108-117	myogenin	Mus musculus	134-142
26892397-6	2016	Using isolated mouse satellite cells (i.e., myoblasts), we observed that activation of TRPV1 by its agonist capsaicin (CAP) augmented myogenin protein levels.	Capsaicin	119-122	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	87-92
26892397-6	2016	Using isolated mouse satellite cells (i.e., myoblasts), we observed that activation of TRPV1 by its agonist capsaicin (CAP) augmented myogenin protein levels.	Capsaicin	119-122	myogenin	Mus musculus	134-142
27157371-7	2016	Capsaicin (1 muM) abolished spontaneous contractions in mucosa but had an excitatory action on detrusor contractility.	Capsaicin	0-9	latexin	Homo sapiens	13-16
28011952-2	2016	Small quantities of endogenous CO are produced during heme degradation by heme oxygenase (HO-1), however, the involvement of the capsaicin-sensitive afferent neurons releasing calcitonin gene related peptide (CGRP) and anti-oxidative factors and mechanisms in the CO-induced gastroprotection against stress ulcerogenesis has been little studied.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	176-207
28011952-2	2016	Small quantities of endogenous CO are produced during heme degradation by heme oxygenase (HO-1), however, the involvement of the capsaicin-sensitive afferent neurons releasing calcitonin gene related peptide (CGRP) and anti-oxidative factors and mechanisms in the CO-induced gastroprotection against stress ulcerogenesis has been little studied.	Capsaicin	129-138	calcitonin-related polypeptide alpha	Rattus norvegicus	209-213
28011952-15	2016	The concurrent treatment of CORM-2 with exogenous CGRP in rats with or without sensory nerves tended to decrease the number of WRS lesions as compared with CORM-2 alone pretreated animals and significantly increased the GBF over the values measured in gastric mucosa of CORM-2 alone pretreated rats with or without capsaicin denervation.	Capsaicin	315-324	calcitonin-related polypeptide alpha	Rattus norvegicus	50-54
28011952-16	2016	Such combined administration of CORM-2 and CGRP in rats with capsaicin denervation significantly inhibited an increase in MDA and 4-HNE content and evoked a significant increase in the GSH concentration (P &lt; 0.05) remaining without significant effect on the increase in SOD activity observed with CORM-2 alone.	Capsaicin	61-70	calcitonin-related polypeptide alpha	Rattus norvegicus	43-47
27523907-3	2016	The dental pulp and periradicular tissues are innervated by capsaicin-sensitive neurons known to release CGRP.	Capsaicin	60-69	calcitonin-related polypeptide alpha	Rattus norvegicus	105-109
27523907-7	2016	Ablation of capsaicin-sensitive neurons was verified with confocal microscopy, capsaicin-induced eye-wipe nocifensive behavior test, and by measurement of immunoreactive CGRP levels in the dental pulp.	Capsaicin	12-21	calcitonin-related polypeptide alpha	Rattus norvegicus	170-174
27523907-12	2016	In addition, the neonatal capsaicin group showed a significant depletion of susceptible neurons and CGRP in the dental pulp compared with control.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	100-104
27525636-0	2016	Capsaicin-Sensitive Sensory Nerves Mediate the Cellular and Microvascular Effects of H2S via TRPA1 Receptor Activation and Neuropeptide Release.	Capsaicin	0-9	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	93-98
27525636-11	2016	H2S activates capsaicin-sensitive sensory nerves through TRPA1 receptors and the resultant vasodilatation is mediated by the release of vasoactive sensory neuropeptides CGRP and substance P.	Capsaicin	14-23	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	57-62
27525636-11	2016	H2S activates capsaicin-sensitive sensory nerves through TRPA1 receptors and the resultant vasodilatation is mediated by the release of vasoactive sensory neuropeptides CGRP and substance P.	Capsaicin	14-23	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	169-173
27525636-11	2016	H2S activates capsaicin-sensitive sensory nerves through TRPA1 receptors and the resultant vasodilatation is mediated by the release of vasoactive sensory neuropeptides CGRP and substance P.	Capsaicin	14-23	tachykinin 1	Mus musculus	178-189
27157371-9	2016	Pretreatment with the CGRP (calcitonin gene-related peptide) antagonist hCGRP 8-37 (2 muM) inhibited CGRP or capsaicin induced suppression of spontaneous contractions.	Capsaicin	109-118	calcitonin related polypeptide alpha	Homo sapiens	22-26
28011952-19	2016	Both, the expression of SOD-2- and GPx-1 mRNA was significantly increased in capsaicin denervated rats exposed to WRS rats (P &lt; 0.05) and this effect was abolished by the pretreatment with CORM-2.	Capsaicin	77-86	superoxide dismutase 2	Rattus norvegicus	24-29
28011952-19	2016	Both, the expression of SOD-2- and GPx-1 mRNA was significantly increased in capsaicin denervated rats exposed to WRS rats (P &lt; 0.05) and this effect was abolished by the pretreatment with CORM-2.	Capsaicin	77-86	glutathione peroxidase 1	Rattus norvegicus	35-40
27157371-9	2016	Pretreatment with the CGRP (calcitonin gene-related peptide) antagonist hCGRP 8-37 (2 muM) inhibited CGRP or capsaicin induced suppression of spontaneous contractions.	Capsaicin	109-118	calcitonin related polypeptide alpha	Homo sapiens	72-77
27157371-9	2016	Pretreatment with the CGRP (calcitonin gene-related peptide) antagonist hCGRP 8-37 (2 muM) inhibited CGRP or capsaicin induced suppression of spontaneous contractions.	Capsaicin	109-118	latexin	Homo sapiens	86-89
28011952-20	2016	The expression of SOD-2 tended to decrease, though insignificantly, in rats pretreated with the combination of CORM-2 and CGRP as compared with that detected in CORM-2 alone in rats with capsaicin denervation.	Capsaicin	187-196	superoxide dismutase 2	Rattus norvegicus	18-23
28011952-20	2016	The expression of SOD-2 tended to decrease, though insignificantly, in rats pretreated with the combination of CORM-2 and CGRP as compared with that detected in CORM-2 alone in rats with capsaicin denervation.	Capsaicin	187-196	calcitonin-related polypeptide alpha	Rattus norvegicus	122-126
27157371-9	2016	Pretreatment with the CGRP (calcitonin gene-related peptide) antagonist hCGRP 8-37 (2 muM) inhibited CGRP or capsaicin induced suppression of spontaneous contractions.	Capsaicin	109-118	calcitonin related polypeptide alpha	Homo sapiens	73-77
28011952-21	2016	In contrast, the mRNA expression of GPx-1 was significantly decreased in gastric mucosa of capsaicin-denervated rats treated with the combination of CORM-2 and CGRP as compared with CORM-2 alone pretreated animals.	Capsaicin	91-100	glutathione peroxidase 1	Rattus norvegicus	36-41
27653550-4	2016	Blocking or deleting the CB1 receptor only reduces both anandamide- and capsaicin-evoked responses in ACR neurons.	Capsaicin	72-81	cannabinoid receptor 1	Homo sapiens	25-28
28011952-21	2016	In contrast, the mRNA expression of GPx-1 was significantly decreased in gastric mucosa of capsaicin-denervated rats treated with the combination of CORM-2 and CGRP as compared with CORM-2 alone pretreated animals.	Capsaicin	91-100	calcitonin-related polypeptide alpha	Rattus norvegicus	160-164
27586050-7	2016	In contrast, myristicin inhibited neutrophil [Ca(2+)]i flux stimulated by fMLF and IL-8 and inhibited capsaicin-induced Ca(2+) influx in TRPV1-transfected HEK293 cells.	Capsaicin	102-111	transient receptor potential cation channel subfamily V member 1	Homo sapiens	137-142
27671317-4	2016	Capsaicin, the specific TRPV1 agonist, dose-dependently reduced mitochondrial membrane potential and was blocked by the TRPV1 antagonist capsazepine or the calcineurin inhibitor cyclosporine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
27671317-4	2016	Capsaicin, the specific TRPV1 agonist, dose-dependently reduced mitochondrial membrane potential and was blocked by the TRPV1 antagonist capsazepine or the calcineurin inhibitor cyclosporine.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
27670299-8	2016	IFN-alpha also inhibited nociceptive transmission by reducing capsaicin-induced internalization of NK-1 and phosphorylation of extracellular signal-regulated kinase (ERK) in superficial dorsal horn neurons.	Capsaicin	62-71	Eph receptor B1	Rattus norvegicus	127-164
27670299-8	2016	IFN-alpha also inhibited nociceptive transmission by reducing capsaicin-induced internalization of NK-1 and phosphorylation of extracellular signal-regulated kinase (ERK) in superficial dorsal horn neurons.	Capsaicin	62-71	Eph receptor B1	Rattus norvegicus	166-169
27653550-4	2016	Blocking or deleting the CB1 receptor only reduces both anandamide- and capsaicin-evoked responses in ACR neurons.	Capsaicin	72-81	acrosin	Homo sapiens	102-105
27606946-2	2016	Since the precise structure of TRPV1 was obtained by electron cryo-microscopy, the binding mode of representative agonists such as capsaicin and resiniferatoxin (RTX) has been extensively characterized; however, detailed information on the binding mode of other vanilloids remains lacking.	Capsaicin	131-140	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
27318088-0	2016	Capsaicin inhibits the Wnt/beta-catenin signaling pathway by down-regulating PP2A.	Capsaicin	0-9	catenin beta 1 L homeolog	Xenopus laevis	27-39
27318088-0	2016	Capsaicin inhibits the Wnt/beta-catenin signaling pathway by down-regulating PP2A.	Capsaicin	0-9	protein phosphatase 2 regulatory subunit B, beta L homeolog	Xenopus laevis	77-81
27318088-2	2016	In our chemical library screening with frog embryo, capsaicin was found to repress the Wnt/beta-catenin signaling.	Capsaicin	52-61	catenin beta 1 L homeolog	Xenopus laevis	91-103
27318088-4	2016	In agreement with these phenotypes, capsaicin suppressed the expression of Wnt target genes such as Siamois and Chordin in the organizer region of embryo and in Wnt signals-stimulated tissue explants.	Capsaicin	36-45	chordin, gene 1 S homeolog	Xenopus laevis	112-119
27318088-5	2016	In addition, the cellular level of beta-catenin, a key component of Wnt pathway, was down-regulated in capsaicin-treated embryonic cells.	Capsaicin	103-112	catenin beta 1 L homeolog	Xenopus laevis	35-47
27318088-7	2016	In support of this, capsaicin up-regulated the level of GSK3- or CK1-phosphorylated beta-catenin, concomitantly lowering that of its de-phosphorylated version.	Capsaicin	20-29	glycogen synthase kinase 3 beta L homeolog	Xenopus laevis	56-60
27318088-7	2016	In support of this, capsaicin up-regulated the level of GSK3- or CK1-phosphorylated beta-catenin, concomitantly lowering that of its de-phosphorylated version.	Capsaicin	20-29	catenin beta 1 L homeolog	Xenopus laevis	84-96
27318088-8	2016	Notably, capsaicin augmented the phosphorylation of a phosphatase, PP2A at tyrosine 307, suggesting its repression of the enzymatic activity of the phosphatase.	Capsaicin	9-18	protein phosphatase 2 regulatory subunit B, beta L homeolog	Xenopus laevis	67-71
27318088-9	2016	Furthermore, capsaicin still enhanced beta-catenin phosphorylation in cells treated with a GSK3 inhibitor, LiCl but not in those treated with a phosphatase inhibitor, okadaic acid.	Capsaicin	13-22	catenin beta 1 L homeolog	Xenopus laevis	38-50
27318088-9	2016	Furthermore, capsaicin still enhanced beta-catenin phosphorylation in cells treated with a GSK3 inhibitor, LiCl but not in those treated with a phosphatase inhibitor, okadaic acid.	Capsaicin	13-22	glycogen synthase kinase 3 beta L homeolog	Xenopus laevis	91-95
27318088-10	2016	Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.	Capsaicin	38-47	protein phosphatase 2 regulatory subunit B, beta L homeolog	Xenopus laevis	150-154
27318088-10	2016	Together, these results indicate that capsaicin inhibits the patterning of the dorso-ventral and anterior-posterior body axes of embryo by repressing PP2A and thereby down-regulating the Wnt/beta-catenin signaling.	Capsaicin	38-47	catenin beta 1 L homeolog	Xenopus laevis	191-203
27599722-0	2016	Reactivation of mutant p53 by capsaicin, the major constituent of peppers.	Capsaicin	30-39	tumor protein p53	Homo sapiens	23-26
27335281-5	2016	Intravenous injection of the TRPV1 agonist capsaicin produced hypotension and bradycardia in control rats, but this response was absent in TRPV1(-/-) rats.	Capsaicin	43-52	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	29-34
27598321-1	2016	The in vivo cutaneous nerve regeneration model using capsaicin is applied extensively to study the regenerative mechanisms and therapeutic efficacy of disease modifying molecules for small fiber neuropathy (SFN).	Capsaicin	53-62	RNA exonuclease 2	Homo sapiens	207-210
27598321-6	2016	This study indicates that capsaicin application results in significant loss of epidermal NRP-1 receptor expression, whereas diabetic subjects presenting small fiber neuropathy show full epidermal NRP-1 expression in contrast to the basal expression pattern seen in healthy controls.	Capsaicin	26-35	neuropilin 1	Homo sapiens	89-94
27598321-7	2016	Capsaicin induced a decrease in dermal non-vascular NRP-1 receptor expression which did not appear in diabetic polyneuropathy.	Capsaicin	0-9	neuropilin 1	Homo sapiens	52-57
26945213-0	2016	Biglycan Inhibits Capsaicin-Induced Substance P Release by Cultured Dorsal Root Ganglion Neurons.	Capsaicin	18-27	biglycan	Oryctolagus cuniculus	0-8
26945213-1	2016	OBJECTIVE: The purpose of this study was to examine the inhibitory effects of biglycan on substance P release from cultured sensory neurons in response to capsaicin.	Capsaicin	155-164	biglycan	Oryctolagus cuniculus	78-86
26945213-5	2016	We tested the hypothesis that biglycan inhibits substance P release in response to capsaicin.	Capsaicin	83-92	biglycan	Oryctolagus cuniculus	30-38
27599722-6	2016	Capsaicin (CPS) is the major constituent of peppers and show antitumor activity by targeting several molecular pathway, however, its effect on mutant p53 reactivation has not been assessed yet.	Capsaicin	0-9	tumor protein p53	Homo sapiens	150-153
27599722-7	2016	In this study we aimed at investigating whether mutant p53 could be a new target of capsaicin-induced cell death and the underlying mechanisms.	Capsaicin	84-93	tumor protein p53	Homo sapiens	55-58
27599722-8	2016	METHODS: p53 levels were analysed by western blot upon capsaicin treatment in the presence of the autophagy inhibitor chloroquine.	Capsaicin	55-64	tumor protein p53	Homo sapiens	9-12
27599722-11	2016	RESULTS: Here, we show that capsaicin induced autophagy that was, at least in part, responsible of mutant p53 protein degradation.	Capsaicin	28-37	tumor protein p53	Homo sapiens	106-109
27599722-12	2016	Abrogation of mutant p53 by capsaicin restored wild-type p53 activities over mutant p53 functions, contributing to cancer cell death.	Capsaicin	28-37	tumor protein p53	Homo sapiens	21-24
27599722-12	2016	Abrogation of mutant p53 by capsaicin restored wild-type p53 activities over mutant p53 functions, contributing to cancer cell death.	Capsaicin	28-37	tumor protein p53	Homo sapiens	57-60
27599722-12	2016	Abrogation of mutant p53 by capsaicin restored wild-type p53 activities over mutant p53 functions, contributing to cancer cell death.	Capsaicin	28-37	tumor protein p53	Homo sapiens	57-60
27599722-14	2016	CONCLUSION: These findings demonstrate for the first time that capsaicin may reduce mutant p53 levels and reactivate wild-type p53 protein in mutant p53-carrying cells and the p53 reactivation contributes to capsaicin-induced cell death.	Capsaicin	63-72	tumor protein p53	Homo sapiens	91-94
27599722-14	2016	CONCLUSION: These findings demonstrate for the first time that capsaicin may reduce mutant p53 levels and reactivate wild-type p53 protein in mutant p53-carrying cells and the p53 reactivation contributes to capsaicin-induced cell death.	Capsaicin	63-72	tumor protein p53	Homo sapiens	127-130
27599722-14	2016	CONCLUSION: These findings demonstrate for the first time that capsaicin may reduce mutant p53 levels and reactivate wild-type p53 protein in mutant p53-carrying cells and the p53 reactivation contributes to capsaicin-induced cell death.	Capsaicin	63-72	tumor protein p53	Homo sapiens	127-130
27599722-14	2016	CONCLUSION: These findings demonstrate for the first time that capsaicin may reduce mutant p53 levels and reactivate wild-type p53 protein in mutant p53-carrying cells and the p53 reactivation contributes to capsaicin-induced cell death.	Capsaicin	63-72	tumor protein p53	Homo sapiens	127-130
26914965-7	2016	Capsaicin-induced and to a lesser extent also KCl-induced CGRP releases were also augmented after Bv8 treatment.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	58-62
26914965-7	2016	Capsaicin-induced and to a lesser extent also KCl-induced CGRP releases were also augmented after Bv8 treatment.	Capsaicin	0-9	prokineticin 2	Mus musculus	98-101
27094759-1	2016	BACKGROUND: Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	68-116
27251170-5	2016	Capsaicin-sensitive afferents were defunctionalized with the TRPV1 agonist resiniferatoxin (RTX; 30-70-100 mug/kg s.c. pretreatment).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	61-66
27094759-1	2016	BACKGROUND: Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese.	Capsaicin	147-156	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
27094759-1	2016	BACKGROUND: Capsaicin is an ingredient of red peppers that binds to transient receptor potential vanilloid subtype 1 (TRPV1), and Koreans eat more capsaicin-rich food than do Japanese.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
27558883-9	2016	We found that capsaicin-evoked currents are inhibited by heat shock in dorsal root ganglion neurons and transfected HEK cells expressing Hsc70 and TRPV1.	Capsaicin	14-23	heat shock protein 8	Mus musculus	137-142
27127846-6	2016	Calcium-imaging studies in cultured rat DRG neurons demonstrated dose-dependent inhibition of capsaicin responses in the presence of N/OFQ, with an IC50 of 8.6 pM.	Capsaicin	94-103	prepronociceptin	Homo sapiens	133-138
27127846-7	2016	In cultured human DRG neurons, 32% inhibition of capsaicin responses was observed in the presence of 1 pM N/OFQ (P &lt; 0.001).	Capsaicin	49-58	prepronociceptin	Homo sapiens	106-111
27127846-8	2016	The maximum inhibition of capsaicin responses was greater with N/OFQ than mu-opioid receptor agonist DAMGO.	Capsaicin	26-35	prepronociceptin	Homo sapiens	63-68
27655547-11	2016	The capsaicin group showed increases in the content of IL-13 and IL-8 in BALF (P&lt;0.05).	Capsaicin	4-13	interleukin 13	Mus musculus	55-60
27655547-11	2016	The capsaicin group showed increases in the content of IL-13 and IL-8 in BALF (P&lt;0.05).	Capsaicin	4-13	chemokine (C-X-C motif) ligand 15	Mus musculus	65-69
27342418-6	2016	Adriamycin treatment resulted in profound reductions in the cutaneous neurogenic sensory vasodilatation and plasma extravasation evoked by the TRPV1 and TRPA1 agonists capsaicin and mustard oil, respectively.	Capsaicin	168-177	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	143-148
27342418-6	2016	Adriamycin treatment resulted in profound reductions in the cutaneous neurogenic sensory vasodilatation and plasma extravasation evoked by the TRPV1 and TRPA1 agonists capsaicin and mustard oil, respectively.	Capsaicin	168-177	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	153-158
27655547-9	2016	Compared with the control group, the asthma and capsaicin groups showed increases in the content of IL-13 and IL-8 in BALF and the mRNA expression of TRPV1 in lung tissue (P&lt;0.05).	Capsaicin	48-57	interleukin 13	Mus musculus	100-105
27655547-9	2016	Compared with the control group, the asthma and capsaicin groups showed increases in the content of IL-13 and IL-8 in BALF and the mRNA expression of TRPV1 in lung tissue (P&lt;0.05).	Capsaicin	48-57	chemokine (C-X-C motif) ligand 15	Mus musculus	110-114
27655547-9	2016	Compared with the control group, the asthma and capsaicin groups showed increases in the content of IL-13 and IL-8 in BALF and the mRNA expression of TRPV1 in lung tissue (P&lt;0.05).	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	150-155
27558883-9	2016	We found that capsaicin-evoked currents are inhibited by heat shock in dorsal root ganglion neurons and transfected HEK cells expressing Hsc70 and TRPV1.	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	147-152
27367032-4	2016	The inhibition of autophagy, by using the specific inhibitor bafilomycin A or Beclin 1 knock-down, enhanced the CPS-induced cell death, demonstrating that CPS-induced autophagy acts as a pro-survival process in BC cells.	Capsaicin	112-115	beclin 1	Homo sapiens	78-86
27563913-1	2016	Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca(2+) permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX).	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
27563913-1	2016	Transient Receptor Potential Vanilloid 1 (TRPV1) is a non-selective, Ca(2+) permeable cation channel activated by noxious heat, and chemical ligands, such as capsaicin and resiniferatoxin (RTX).	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
27367032-4	2016	The inhibition of autophagy, by using the specific inhibitor bafilomycin A or Beclin 1 knock-down, enhanced the CPS-induced cell death, demonstrating that CPS-induced autophagy acts as a pro-survival process in BC cells.	Capsaicin	155-158	beclin 1	Homo sapiens	78-86
27367032-7	2016	By PTCH2 knock-down we found that the Hedgehog signaling pathway is involved in the CPS-induced autophagy and EMT phenotype.Finally, we also showed that the CPS-resistant EMT-positive BC cells displayed an increased drug-resistance to the cytotoxic effects of mitomycin C, gemcitabine and doxorubicine drugs commonly used in BC therapy.	Capsaicin	84-87	patched 2	Homo sapiens	3-8
27367032-5	2016	By using PCR arrays and FACS analysis, we found that the CPS-treated BC cells displayed typical mesenchymal features of the epithelial mesenchymal transition (EMT) as elongated shape and over-expression of vimentin, alpha5 and beta1 integrin subunits, integrin-like kinase and the anti-apoptotic Bcl-2 proteins.	Capsaicin	57-60	vimentin	Homo sapiens	206-214
27367032-7	2016	By PTCH2 knock-down we found that the Hedgehog signaling pathway is involved in the CPS-induced autophagy and EMT phenotype.Finally, we also showed that the CPS-resistant EMT-positive BC cells displayed an increased drug-resistance to the cytotoxic effects of mitomycin C, gemcitabine and doxorubicine drugs commonly used in BC therapy.	Capsaicin	157-160	patched 2	Homo sapiens	3-8
27367032-5	2016	By using PCR arrays and FACS analysis, we found that the CPS-treated BC cells displayed typical mesenchymal features of the epithelial mesenchymal transition (EMT) as elongated shape and over-expression of vimentin, alpha5 and beta1 integrin subunits, integrin-like kinase and the anti-apoptotic Bcl-2 proteins.	Capsaicin	57-60	integrin subunit beta 1	Homo sapiens	227-241
27367032-5	2016	By using PCR arrays and FACS analysis, we found that the CPS-treated BC cells displayed typical mesenchymal features of the epithelial mesenchymal transition (EMT) as elongated shape and over-expression of vimentin, alpha5 and beta1 integrin subunits, integrin-like kinase and the anti-apoptotic Bcl-2 proteins.	Capsaicin	57-60	BCL2 apoptosis regulator	Homo sapiens	296-301
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	desert hedgehog signaling molecule	Homo sapiens	72-75
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	patched 2	Homo sapiens	76-81
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	zinc finger E-box binding homeobox 2	Homo sapiens	82-86
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	CD24 molecule	Homo sapiens	140-144
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	vascular endothelial growth factor A	Homo sapiens	146-151
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	TIMP metallopeptidase inhibitor 1	Homo sapiens	156-161
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	CD44 molecule (Indian blood group)	Homo sapiens	176-180
27367032-6	2016	Moreover, we demonstrated that CPS treatment stimulates upregulation of Dhh/Ptch2/Zeb2 members of the Hedgehog signaling pathway, increases CD24, VEGFA and TIMP1 and decreases CD44 and ALCAM mRNA expression levels.	Capsaicin	31-34	activated leukocyte cell adhesion molecule	Homo sapiens	185-190
27697214-5	2016	In fact, capsaicin and its analog capsinoids, representative agonists of TRPV1, mimic the effects of cold to decrease body fatness through the activation and recruitment of BAT.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
27180305-1	2016	Vanilloids including capsaicin and resiniferatoxin are potent transient receptor potential vanilloid type 1 (TRPV1) agonists.	Capsaicin	21-30	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-107
27180305-1	2016	Vanilloids including capsaicin and resiniferatoxin are potent transient receptor potential vanilloid type 1 (TRPV1) agonists.	Capsaicin	21-30	transient receptor potential cation channel subfamily V member 1	Homo sapiens	109-114
27180305-2	2016	TRPV1 overstimulation selectively ablates capsaicin-sensitive sensory neurons in animal models in vivo.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
27180305-9	2016	We assume that the low vanilloid-sensitivity of prostate and breast cancer cells is associated with low expression levels of TRPV1, since ectopic TRPV1 expression rendered them susceptible to the cytotoxic effect of vanilloids evidenced by plateau-type Ca(2+) signals, mitochondrial Ca(2+) accumulation and Na(+)- and Ca(2+)-dependent membrane disorganization.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	125-130
27485456-8	2016	Expression of TRPV1 is reduced in patients with idiopathic rhinitis after capsaicin treatment.	Capsaicin	74-83	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
27174467-0	2016	Capsaicin induces browning of white adipose tissue and counters obesity by activating TRPV1 channel-dependent mechanisms.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
27174467-5	2016	EXPERIMENTAL APPROACH: We evaluated the effect of dietary capsaicin to induce a browning program in WAT by activating TRPV1 channels to prevent diet-induced obesity using wild-type and TRPV1(-/-) mouse models.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	118-123
27174467-7	2016	KEY RESULTS: Capsaicin stimulated the expression of brown fat-specific thermogenic uncoupling protein-1 and bone morphogenetic protein-8b in WAT.	Capsaicin	13-22	bone morphogenetic protein 8b	Mus musculus	108-137
27174467-8	2016	Capsaicin triggered browning of WAT by promoting sirtuin-1 expression and activity via TRPV1 channel-dependent elevation of intracellular Ca(2) (+) and phosphorylation of Ca(2) (+) /calmodulin-activated protein kinase II and AMP-activated kinase.	Capsaicin	0-9	sirtuin 1	Mus musculus	49-58
27174467-8	2016	Capsaicin triggered browning of WAT by promoting sirtuin-1 expression and activity via TRPV1 channel-dependent elevation of intracellular Ca(2) (+) and phosphorylation of Ca(2) (+) /calmodulin-activated protein kinase II and AMP-activated kinase.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	87-92
27174467-9	2016	Capsaicin increased the expression of PPARgamma 1 coactivator alpha and enhanced metabolic and ambulatory activity.	Capsaicin	0-9	peroxisome proliferator activated receptor gamma	Mus musculus	38-47
27174467-10	2016	Further, capsaicin stimulated sirtuin-1-dependent deacetylation of PPARgamma and the transcription factor PRDM-16 and facilitated PPARgamma-PRDM-16 interaction to induce browning of WAT.	Capsaicin	9-18	sirtuin 1	Mus musculus	30-39
27174467-10	2016	Further, capsaicin stimulated sirtuin-1-dependent deacetylation of PPARgamma and the transcription factor PRDM-16 and facilitated PPARgamma-PRDM-16 interaction to induce browning of WAT.	Capsaicin	9-18	peroxisome proliferator activated receptor gamma	Mus musculus	67-76
27174467-10	2016	Further, capsaicin stimulated sirtuin-1-dependent deacetylation of PPARgamma and the transcription factor PRDM-16 and facilitated PPARgamma-PRDM-16 interaction to induce browning of WAT.	Capsaicin	9-18	PR domain containing 16	Mus musculus	106-113
27174467-10	2016	Further, capsaicin stimulated sirtuin-1-dependent deacetylation of PPARgamma and the transcription factor PRDM-16 and facilitated PPARgamma-PRDM-16 interaction to induce browning of WAT.	Capsaicin	9-18	peroxisome proliferator activated receptor gamma	Mus musculus	130-139
27174467-10	2016	Further, capsaicin stimulated sirtuin-1-dependent deacetylation of PPARgamma and the transcription factor PRDM-16 and facilitated PPARgamma-PRDM-16 interaction to induce browning of WAT.	Capsaicin	9-18	PR domain containing 16	Mus musculus	140-147
27174467-12	2016	CONCLUSIONS AND INTERPRETATIONS: Our results show for the first time that activation of TRPV1 channels by dietary capsaicin triggers browning of WAT to counteract obesity.	Capsaicin	114-123	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	88-93
26984967-5	2016	RESULTS: Seven days after it was administered to tissues outside the calvaria, BoNT-A inhibited responses of C-type meningeal nociceptors to stimulation of their intracranial dural receptive fields with the TRPV1 agonist capsaicin and the TRPA1 agonist mustard oil.	Capsaicin	221-230	transient receptor potential cation channel subfamily V member 1	Homo sapiens	207-212
27391380-6	2016	Mechanistic studies identified the ion channels TRPV1 and TRPA1 as targets of capsaicin in pepper spray, and of the tear gas agents chloroacetophenone, CS, and CR.	Capsaicin	78-87	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
27391380-6	2016	Mechanistic studies identified the ion channels TRPV1 and TRPA1 as targets of capsaicin in pepper spray, and of the tear gas agents chloroacetophenone, CS, and CR.	Capsaicin	78-87	transient receptor potential cation channel subfamily A member 1	Homo sapiens	58-63
26965218-7	2016	Administration of capsaicin (a TRPV1 agonist) into the RVM decreased nociceptive behavioural responses in the inflammatory phase of the formalin test (phase 2).	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	31-36
27339229-1	2016	There is enormous interest toward vanilloid agonists of the pain receptor TRPV1 in analgesic therapy, but the mechanisms of their sensory neuron-blocking effects at high or repeated doses are still a matter of debate.	Capsaicin	34-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
27339229-2	2016	Our results have demonstrated that capsaicin and resiniferatoxin form nanomolar complexes with calmodulin, and competitively inhibit TRPV1-calmodulin interaction.	Capsaicin	35-44	calmodulin 1	Homo sapiens	95-105
27339229-2	2016	Our results have demonstrated that capsaicin and resiniferatoxin form nanomolar complexes with calmodulin, and competitively inhibit TRPV1-calmodulin interaction.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	133-138
27339229-2	2016	Our results have demonstrated that capsaicin and resiniferatoxin form nanomolar complexes with calmodulin, and competitively inhibit TRPV1-calmodulin interaction.	Capsaicin	35-44	calmodulin 1	Homo sapiens	139-149
27446273-7	2016	In addition, the effects of capsaicin and cisplatin were evaluated for their abilities in inducing calreticulin membrane translocation and mediating ICD in human osteosarcoma cells (MG-63).	Capsaicin	28-37	calreticulin	Homo sapiens	99-111
27446273-9	2016	However, only capsaicin induced a rapid translocation of CRT from the intracellular space to the cell surface.	Capsaicin	14-23	calreticulin	Homo sapiens	57-60
27446273-10	2016	Treatment with capsaicin increased phagocytosis of MG-63 cells by dendritic cells (DCs), and these MG-63-loaded DCs could efficiently stimulate the secretion of IFN-gamma by lymphocytes.	Capsaicin	15-24	interferon gamma	Homo sapiens	161-170
27574502-2	2016	Here we demonstrate that the VR1 agonists, capsaicin (CP) and resiniferatoxin (RTX), enhance antiviral CTL responses by increasing MHC class I-restricted viral antigen presentation in dendritic cells (DCs).	Capsaicin	43-52	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-32
26099309-12	2016	The TRPV1 channel is activated by oxidative stress and capsaicin and it is blocked by capsazepine.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
27439609-8	2016	Olvanil was able to desensitise TRPV1 responses to further capsaicin exposure more effectively than capsaicin.	Capsaicin	59-68	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-37
26932896-2	2016	We conducted studies to determine if the presence of acid in the mucosa/submucosa and direct activation of TRPV1 by capsaicin elicited symptoms in normal healthy subjects.	Capsaicin	116-125	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
27473037-4	2016	Increased expression of phosphorylated calmodulin-dependent protein kinase IIdelta and mitogen-activated protein kinases were found in TRPV1 agonist capsaicin-treated cardiomyocytes.	Capsaicin	149-158	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	135-140
27473037-6	2016	Capsaicin induced an increase in expression of ornithine decarboxylase protein, which is the key enzyme in polyamine biosynthesis in cardiomyocytes.	Capsaicin	0-9	ornithine decarboxylase, structural 1	Mus musculus	47-70
27473037-7	2016	Nevertheless, there was no obvious change of ornithine decarboxylase expression in TRPV1 knockdown cells after capsaicin treatment, and specific inhibitors of calmodulin-dependent protein kinase IIdelta or p38 downregulated the capsaicin-induced expression of ornithine decarboxylase.	Capsaicin	228-237	mitogen-activated protein kinase 14	Mus musculus	206-209
27473037-7	2016	Nevertheless, there was no obvious change of ornithine decarboxylase expression in TRPV1 knockdown cells after capsaicin treatment, and specific inhibitors of calmodulin-dependent protein kinase IIdelta or p38 downregulated the capsaicin-induced expression of ornithine decarboxylase.	Capsaicin	228-237	ornithine decarboxylase, structural 1	Mus musculus	260-283
27455231-8	2016	This review summarizes the historical background, source, structure and analogues of capsaicin, and capsaicin-triggered TRPV1 signaling and desensitization processes.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-125
27439609-1	2016	BACKGROUND: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic compound.	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	144-189
27439609-9	2016	Intraplantar injection of capsaicin (0.1, 0.3 and 1 mug) produced a robust TRPV1-dependant thermal hyperalgesia in rats, whilst olvanil (0.1, 0.3 and 1 mug) produced no hyperalgesia, emphasizing its lack of pungency.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	75-80
27439609-1	2016	BACKGROUND: Olvanil (NE 19550) is a non-pungent synthetic analogue of capsaicin, the natural pungent ingredient of capsicum which activates the transient receptor potential vanilloid type-1 (TRPV1) channel and was developed as a potential analgesic compound.	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	191-196
26351174-6	2016	The cell viability decreased and the punctate patterns of LC3 in U251 cells were observed after Capsaicin treatment.	Capsaicin	96-105	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	58-61
27400965-7	2016	RESULTS: Acute exposure to 1 muM PGE2 augments the capsaicin-evoked release of iCGRP, and this effect is blocked by the PKA inhibitor H-89.	Capsaicin	51-60	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	120-123
27388773-7	2016	Oral administration of the TRPV1 agonist, capsaicin, suppressed ligature-induced bone loss in mice with fewer tartrate-resistant acid phosphatase (TRAP)-positive cells in alveolar bone.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
27388773-7	2016	Oral administration of the TRPV1 agonist, capsaicin, suppressed ligature-induced bone loss in mice with fewer tartrate-resistant acid phosphatase (TRAP)-positive cells in alveolar bone.	Capsaicin	42-51	acid phosphatase 5, tartrate resistant	Mus musculus	110-145
27388773-7	2016	Oral administration of the TRPV1 agonist, capsaicin, suppressed ligature-induced bone loss in mice with fewer tartrate-resistant acid phosphatase (TRAP)-positive cells in alveolar bone.	Capsaicin	42-51	acid phosphatase 5, tartrate resistant	Mus musculus	147-151
27438088-1	2016	OBJECTIVE: Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	122-171
27438088-1	2016	OBJECTIVE: Acute administration of 5-hydroxytryptamine4 (5-HT4) receptor agonist, mosapride or esophageal infusion of the transient receptor potential vanilloid receptor-1 (TRPV1) agonist capsaicin promotes secondary peristalsis.	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	173-178
27388773-1	2016	The transient receptor potential vanilloid 1 (TRPV1) channel is abundantly expressed in peripheral sensory neurons where it acts as an important polymodal cellular sensor for heat, acidic pH, capsaicin, and other noxious stimuli.	Capsaicin	192-201	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-44
27388773-1	2016	The transient receptor potential vanilloid 1 (TRPV1) channel is abundantly expressed in peripheral sensory neurons where it acts as an important polymodal cellular sensor for heat, acidic pH, capsaicin, and other noxious stimuli.	Capsaicin	192-201	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
26883442-9	2016	It is found that activating TRPV1 by capsaicin inhibits VSMC foam cell formation and the accompanied migration through rescuing the SIRT1 and suppressing NF-kappaB signaling.	Capsaicin	37-46	sirtuin 1	Homo sapiens	132-137
27043357-0	2016	Inhibiting ROS-STAT3-dependent autophagy enhanced capsaicin-induced apoptosis in human hepatocellular carcinoma cells.	Capsaicin	50-59	signal transducer and activator of transcription 3	Homo sapiens	15-20
27043357-10	2016	Capsaicin increased LC3-II and beclin-1 expression and GFP-LC3-positive autophagosomes.	Capsaicin	0-9	beclin 1	Homo sapiens	31-39
27043357-12	2016	Mechanistically, capsaicin upregulated the Stat3 activity which contributed to autophagy.	Capsaicin	17-26	signal transducer and activator of transcription 3	Homo sapiens	43-48
27043357-14	2016	Moreover, NAC abrogated the effects of capsaicin on Stat3-dependent autophagy.	Capsaicin	39-48	signal transducer and activator of transcription 3	Homo sapiens	52-57
27043357-15	2016	In this study, we demonstrated that capsaicin increased the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3)-dependent autophagy through the generation of ROS signaling pathways in human hepatoma.	Capsaicin	36-45	signal transducer and activator of transcription 3	Homo sapiens	79-129
27043357-15	2016	In this study, we demonstrated that capsaicin increased the phosphorylation of signal transducer and activator of transcription 3 (p-STAT3)-dependent autophagy through the generation of ROS signaling pathways in human hepatoma.	Capsaicin	36-45	signal transducer and activator of transcription 3	Homo sapiens	133-138
26883442-9	2016	It is found that activating TRPV1 by capsaicin inhibits VSMC foam cell formation and the accompanied migration through rescuing the SIRT1 and suppressing NF-kappaB signaling.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
26883442-9	2016	It is found that activating TRPV1 by capsaicin inhibits VSMC foam cell formation and the accompanied migration through rescuing the SIRT1 and suppressing NF-kappaB signaling.	Capsaicin	37-46	nuclear factor kappa B subunit 1	Homo sapiens	154-163
26297536-8	2016	Autoinhibition can be impaired by preincubation with capsaicin, a ligand of the calcium-permeable TRPV1 channel or by blockade of Ca(2+)-ATPase with thapsigargin.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	98-103
27655481-4	2016	Capsaicin and other anti-oxidants are capable of inhibiting tNOX, causing apoptosis of cells, exerting anti-tumor activity.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	60-64
27062607-10	2016	Most TRPM8-positive small neurons also responded to capsaicin, and had significantly larger menthol-induced inward current densities than medium-large cells, most of which did not respond to capsaicin.	Capsaicin	52-61	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	5-10
26967694-1	2016	Transient receptor potential vanilloid 1 (TRPV1) is a polymodal receptor activated by capsaicin, heat, and acid, which plays critical roles in thermosensation and pain.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
26967694-1	2016	Transient receptor potential vanilloid 1 (TRPV1) is a polymodal receptor activated by capsaicin, heat, and acid, which plays critical roles in thermosensation and pain.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
26970286-2	2016	METHODS: Sensitization of TRPV1 in MIA rats was assessed by transient spontaneous pain behavior induced by capsaicin injection in knee joints and electrophysiological changes of dorsal root ganglion (DRG) neurons innervating knee joints in response to capsaicin.	Capsaicin	107-116	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
26970286-2	2016	METHODS: Sensitization of TRPV1 in MIA rats was assessed by transient spontaneous pain behavior induced by capsaicin injection in knee joints and electrophysiological changes of dorsal root ganglion (DRG) neurons innervating knee joints in response to capsaicin.	Capsaicin	252-261	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
26970286-9	2016	In addition, intra-articular injection of the PKC activator phorbol 12-myristate 13-acetate increased capsaicin-induced pain-related behavior in normal rats.	Capsaicin	102-111	protein kinase C, epsilon	Rattus norvegicus	46-49
27298359-3	2016	Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad).	Capsaicin	91-100	transient receptor potential cation channel subfamily V member 2	Homo sapiens	150-155
27298359-3	2016	Based on these new findings, here we have successfully introduced high-affinity binding of capsaicin and resiniferatoxin to the vanilloid-insensitive TRPV2 channel, using a rationally designed minimal set of four point mutations (F467S-S498F-L505T-Q525E, termed TRPV2_Quad).	Capsaicin	91-100	transient receptor potential cation channel subfamily V member 2	Homo sapiens	262-267
27298359-4	2016	We found that binding of resiniferatoxin activates TRPV2_Quad but the ligand-induced open state is relatively unstable, whereas binding of capsaicin to TRPV2_Quad antagonizes resiniferatoxin-induced activation likely through competition for the same binding sites.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 2	Homo sapiens	152-157
27367652-0	2016	Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	73-102
27298359-7	2016	These results not only validate our current working model for capsaicin activation of TRPV1 but also should help guide the design of drug candidate compounds for this important pain sensor.	Capsaicin	62-71	transient receptor potential cation channel subfamily V member 1	Homo sapiens	86-91
27367652-0	2016	Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	104-108
26942555-4	2016	Several compounds were found to activate TRPV1 channels, and in particular, derivatives 1 and 10 behaved as TRPV1 agonists endowed with good efficacy as compared to capsaicin.	Capsaicin	165-174	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
27367652-0	2016	Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).	Capsaicin	0-9	sirtuin 1	Homo sapiens	114-122
27367652-0	2016	Capsaicin Inhibits Multiple Bladder Cancer Cell Phenotypes by Inhibiting Tumor-Associated NADH Oxidase (tNOX) and Sirtuin1 (SIRT1).	Capsaicin	0-9	sirtuin 1	Homo sapiens	124-129
27367652-5	2016	Here, we set out to elucidate the correlation between tNOX expression and the inhibitory effects of capsaicin in human bladder cancer cells.	Capsaicin	100-109	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	54-58
27367652-6	2016	We showed that capsaicin downregulates tNOX expression and decreases bladder cancer cell growth by enhancing apoptosis.	Capsaicin	15-24	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	39-43
27367652-8	2016	Capsaicin was also shown to inhibit the activation of ERK, thereby reducing the phosphorylation of paxillin and FAK, which leads to decreased cell migration.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	54-57
27367652-8	2016	Capsaicin was also shown to inhibit the activation of ERK, thereby reducing the phosphorylation of paxillin and FAK, which leads to decreased cell migration.	Capsaicin	0-9	protein tyrosine kinase 2	Homo sapiens	112-115
27367652-11	2016	Taken together, our results indicate that capsaicin inhibits the growth of bladder cancer cells by inhibiting tNOX and SIRT1 and thereby reducing proliferation, attenuating migration, and prolonging cell cycle progression.	Capsaicin	42-51	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	110-114
27367652-11	2016	Taken together, our results indicate that capsaicin inhibits the growth of bladder cancer cells by inhibiting tNOX and SIRT1 and thereby reducing proliferation, attenuating migration, and prolonging cell cycle progression.	Capsaicin	42-51	sirtuin 1	Homo sapiens	119-124
27347918-2	2016	Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-75
27347918-2	2016	Capsaicin is an agonist of transient receptor potential vanilloid subtype 1 (TRPV1), which is expressed in nociceptive sensory neurons and a range of secretory epithelia, including salivary glands.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
27347918-7	2016	Capsaicin activates TRPV1, which modulates the permeability of tight junctions (TJ) by regulating the expression and function of putative intercellular adhesion molecules in an ERK (extracelluar signal-regulated kinase) -dependent manner.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
27347918-7	2016	Capsaicin activates TRPV1, which modulates the permeability of tight junctions (TJ) by regulating the expression and function of putative intercellular adhesion molecules in an ERK (extracelluar signal-regulated kinase) -dependent manner.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	177-180
27347918-7	2016	Capsaicin activates TRPV1, which modulates the permeability of tight junctions (TJ) by regulating the expression and function of putative intercellular adhesion molecules in an ERK (extracelluar signal-regulated kinase) -dependent manner.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	182-218
27143360-0	2016	Tyrosine Residue in the TRPV1 Vanilloid Binding Pocket Regulates Deactivation Kinetics.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
27143360-4	2016	The highly conserved tyrosine in position 511 (Tyr(511)) of the rat TRPV1 (rTRPV1) was the first residue to be identified as a necessary participant in the vanilloid-mediated response.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	68-73
27143360-4	2016	The highly conserved tyrosine in position 511 (Tyr(511)) of the rat TRPV1 (rTRPV1) was the first residue to be identified as a necessary participant in the vanilloid-mediated response.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	75-81
27263974-6	2016	Physiological measurements revealed a weaker capsaicin response in Kif1a(+/-) DRG neurons.	Capsaicin	45-54	kinesin family member 1A	Mus musculus	67-72
26930003-5	2016	Calcium influx in response to the TRPA1 agonist allyl-isothiocyanate (AITC) (200 muM) and the TRPV1 stimulator capsaicin (330 nM) in rat trigeminal neurons or TRPA1 and TRPV1 receptor-expressing cell lines was measured by microfluorimetry or radioactive (45)Ca(2+) uptake experiments.	Capsaicin	111-120	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	94-99
27382601-2	2016	Herpes simplex virus (HSV) vector expression of TRPV1 causes cell death in the presence of capsaicin, thereby completely blocking virus replication.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	48-53
26964685-5	2016	We found that warming induced an increase in miniature excitatory postsynaptic current (EPSC) frequency, which was blocked by the transient receptor potential vanilloid-1 (TRPV1) receptor antagonist AMG9810 and mimicked by its agonist capsaicin, suggesting that the synaptic effect is mediated by heat-sensitive TRPV1 channels.	Capsaicin	235-244	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	172-177
27271588-0	2016	Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	68-97
27271588-0	2016	Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	99-103
27271588-0	2016	Capsaicin Inhibited Aggressive Phenotypes through Downregulation of Tumor-Associated NADH Oxidase (tNOX) by POU Domain Transcription Factor POU3F2.	Capsaicin	0-9	POU class 3 homeobox 2	Homo sapiens	140-146
27271588-1	2016	Capsaicin has been reported to preferentially inhibit the activity of tumor-associated NADH oxidase (tNOX), which belongs to a family of growth-related plasma membrane hydroquinone oxidases in cancer/transformed cells.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	70-99
27271588-1	2016	Capsaicin has been reported to preferentially inhibit the activity of tumor-associated NADH oxidase (tNOX), which belongs to a family of growth-related plasma membrane hydroquinone oxidases in cancer/transformed cells.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	101-105
27271588-2	2016	The inhibitory effect of capsaicin on tNOX is associated with cell growth attenuation and apoptosis.	Capsaicin	25-34	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	38-42
27271588-5	2016	In this study, we found that capsaicin-mediated tNOX downregulation and cell migration inhibition were through POU3F2.	Capsaicin	29-38	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	48-52
27271588-5	2016	In this study, we found that capsaicin-mediated tNOX downregulation and cell migration inhibition were through POU3F2.	Capsaicin	29-38	POU class 3 homeobox 2	Homo sapiens	111-117
27271588-8	2016	These findings not only shed light on the molecular mechanism of the anticancer properties of capsaicin, but also the transcription regulation of tNOX expression that may potentially explain how POU3F2 is associated with tumorigenesis.	Capsaicin	94-103	POU class 3 homeobox 2	Homo sapiens	195-201
26930003-6	2016	Calcitonin gene-related peptide (CGRP) release as the indicator of 100 muM AITC - or 100 nM capsaicin-induced peripheral sensory nerve terminal activation was measured by radioimmunoassay.	Capsaicin	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	0-31
26930003-6	2016	Calcitonin gene-related peptide (CGRP) release as the indicator of 100 muM AITC - or 100 nM capsaicin-induced peripheral sensory nerve terminal activation was measured by radioimmunoassay.	Capsaicin	92-101	calcitonin-related polypeptide alpha	Rattus norvegicus	33-37
27052585-6	2016	In addition, spontaneous activity can be augmented with both the transient receptor potential cation channel subfamily V member 1 agonist capsaicin and the peptide bradykinin and completely blocked with neurokinin receptor antagonists.	Capsaicin	138-147	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	65-129
26892478-6	2016	We stimulated rat primary cultured TG neurons with capsaicin or potassium chloride (KCl) to mimic neurogenic inflammation, resulting in release of CGRP and substance P. 5-HT7 receptors were abundantly expressed in TG neurons.	Capsaicin	51-60	calcitonin-related polypeptide alpha	Rattus norvegicus	147-151
26892478-7	2016	Greater than 93 % of 5-HT7 receptor-positive neurons co-expressed CGRP and 56 % co-expressed substance P. Both the capsaicin- and KCl-induced release of CGRP and substance P were unaffected by pretreatment of cultured TG cells with the selective 5-HT7 receptor agonist AS19 and antagonist SB269970.	Capsaicin	115-124	calcitonin-related polypeptide alpha	Rattus norvegicus	153-157
26894912-6	2016	TNF-alpha cTg mice displayed increased trigeminal Cdk5 activity, and this increase was associated with elevated levels of phospho-T407-TRPV1 and capsaicin-evocated Ca influx in cultured trigeminal neurons.	Capsaicin	145-154	tumor necrosis factor	Mus musculus	0-9
27213574-4	2016	Since capsaicin, citric acid, and bradykinin evoked coughing in guinea pigs can be inhibited by drugs that antagonize the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), it was reasoned that the virally-induced hypertussive state may involve alterations in TPRV1 activity.	Capsaicin	6-15	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	122-188
27917413-8	2016	(S)-LCM significantly blocked capsaicin-evoked CGRP release from dural nerve terminals in the rat an ex vivo cranial cup preparation.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	47-51
27159637-5	2016	In comparison to capsaicin, coadministration of 1 and capsaicin increased the half-maximal effective concentration (EC50) of capsaicin-activated TRPV1 currents as shown by a right shift in the dose-response curve, whereas coadministration of 1 with protons failed to inhibit the proton-induced current.	Capsaicin	54-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	145-150
27159637-5	2016	In comparison to capsaicin, coadministration of 1 and capsaicin increased the half-maximal effective concentration (EC50) of capsaicin-activated TRPV1 currents as shown by a right shift in the dose-response curve, whereas coadministration of 1 with protons failed to inhibit the proton-induced current.	Capsaicin	54-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	145-150
27159637-6	2016	Moreover, preadministration of 1, but not 2, inhibited both capsaicin- and proton-induced TRPV1 currents, which might involve channel desensitization.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	90-95
27159637-7	2016	Taken together, 1 and 2 may share the same binding site with capsaicin and act as partial agonists (antagonists) of TRPV1.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-121
27215903-7	2016	In addition, SLIGRL-amide and BAM8-22 each inhibited IAV infection in capsaicin-pre-treated mice that lack functional sensory nerves.	Capsaicin	70-79	myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1	Mus musculus	30-37
27213574-4	2016	Since capsaicin, citric acid, and bradykinin evoked coughing in guinea pigs can be inhibited by drugs that antagonize the transient receptor potential cation channel, subfamily V, member 1 (TRPV1), it was reasoned that the virally-induced hypertussive state may involve alterations in TPRV1 activity.	Capsaicin	6-15	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	190-195
27177419-0	2016	Engineering vanilloid-sensitivity into the rat TRPV2 channel.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	47-52
27022021-7	2016	In addition, Xenopus TRPV1 exhibited drastic species differences in sensitivity to capsaicin, contained in chili peppers, between the two Xenopus species.	Capsaicin	83-92	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	21-26
27022021-8	2016	Another single amino acid substitution within Xenopus TRPV1 is responsible for this species difference, which likely alters the neural and behavioral responses to capsaicin.	Capsaicin	163-172	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	54-59
27178246-6	2016	Nonetheless, intradermal injection of the transient receptor potential channel V1 (TRPV1) agonist capsaicin increased nocifensive behavior as well as mechanical and heat hypersensitivity in FAAH KO relative to wild-type mice.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-81
27177419-3	2016	Cryo-EM structures of TRPV1 and TRPV2 reveal that they adopt similar structures, and identify a putative vanilloid binding pocket near the internal side of TRPV1.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
27178246-6	2016	Nonetheless, intradermal injection of the transient receptor potential channel V1 (TRPV1) agonist capsaicin increased nocifensive behavior as well as mechanical and heat hypersensitivity in FAAH KO relative to wild-type mice.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	83-88
27178246-6	2016	Nonetheless, intradermal injection of the transient receptor potential channel V1 (TRPV1) agonist capsaicin increased nocifensive behavior as well as mechanical and heat hypersensitivity in FAAH KO relative to wild-type mice.	Capsaicin	98-107	fatty acid amide hydrolase	Mus musculus	190-194
27177419-3	2016	Cryo-EM structures of TRPV1 and TRPV2 reveal that they adopt similar structures, and identify a putative vanilloid binding pocket near the internal side of TRPV1.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	32-37
27178246-7	2016	This pro-nociceptive phenotype was accompanied by increases in capsaicin-evoked Fos-like immunoreactive (FLI) cells in spinal dorsal horn regions implicated in nociceptive processing and was attenuated by CB1 (AM251) and TRPV1 (AMG9810) antagonists.	Capsaicin	63-72	FBJ osteosarcoma oncogene	Mus musculus	80-83
27177419-3	2016	Cryo-EM structures of TRPV1 and TRPV2 reveal that they adopt similar structures, and identify a putative vanilloid binding pocket near the internal side of TRPV1.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	156-161
27178246-7	2016	This pro-nociceptive phenotype was accompanied by increases in capsaicin-evoked Fos-like immunoreactive (FLI) cells in spinal dorsal horn regions implicated in nociceptive processing and was attenuated by CB1 (AM251) and TRPV1 (AMG9810) antagonists.	Capsaicin	63-72	cannabinoid receptor 1 (brain)	Mus musculus	205-208
27178246-7	2016	This pro-nociceptive phenotype was accompanied by increases in capsaicin-evoked Fos-like immunoreactive (FLI) cells in spinal dorsal horn regions implicated in nociceptive processing and was attenuated by CB1 (AM251) and TRPV1 (AMG9810) antagonists.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	221-226
27178246-10	2016	Our studies identify a previously unrecognized pro-nociceptive phenotype in FAAH KO mice that was unmasked by capsaicin challenge.	Capsaicin	110-119	fatty acid amide hydrolase	Mus musculus	76-80
26883566-7	2016	Following treatment, the release of CGRP was stimulated using capsaicin or high extracellular potassium.	Capsaicin	62-71	calcitonin related polypeptide alpha	Homo sapiens	36-40
26859646-6	2016	RESULTS: Activation of hTRPA1 by carvacrol and hTRPV1 by capsaicin produced a QX-314-independent reduction of sodium current amplitudes.	Capsaicin	57-66	transient receptor potential cation channel subfamily A member 1	Homo sapiens	23-29
26859646-6	2016	RESULTS: Activation of hTRPA1 by carvacrol and hTRPV1 by capsaicin produced a QX-314-independent reduction of sodium current amplitudes.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-53
26859646-8	2016	Five and 30 mM QX-314 activated hTRPV1 via mechanisms involving the intracellular vanilloid-binding domain and hTRPA1 via unknown mechanisms independent of intracellular cysteins.	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-38
26970948-4	2016	Our results showed that the TRPV1 agonist, capsaicin, increased epileptic outcomes; whilst antagonizing TRPV1 with capsazepine exerts a protective role on paroxysmal discharge.	Capsaicin	43-52	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	28-33
26635025-7	2016	5-HT injection enhanced 5-HT- and capsaicin-evoked calcium signals specifically in isolectin B4 (IB4)-negative neurons; signals were inhibited by a 5-HT2B/2C antagonist and PKCepsilon blocker.	Capsaicin	34-43	5-hydroxytryptamine (serotonin) receptor 2B	Mus musculus	148-154
27163769-1	2016	PURPOSE: The heat-sensitive transient receptor potential vanilloid type-1 (TRPV1) channel (i.e., capsaicin [CAP] receptor) is upregulated in numerous cancers.	Capsaicin	97-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-73
27163769-1	2016	PURPOSE: The heat-sensitive transient receptor potential vanilloid type-1 (TRPV1) channel (i.e., capsaicin [CAP] receptor) is upregulated in numerous cancers.	Capsaicin	97-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-80
27163769-6	2016	RESULTS: Capsaicin (20 muM) and elevating bath temperature above 43 C activated Ca2+ transients more in hPtEC than HCjEC.	Capsaicin	9-18	latexin	Homo sapiens	23-26
27163769-7	2016	Capsaicin induced corresponding changes in inward currents that were inhibited by 20 muM capsazepine (CPZ).	Capsaicin	0-9	latexin	Homo sapiens	85-88
27079706-10	2016	In multivariate analysis, total capsaicin diet scores were positively associated with MMSE scores and inversely associated with serum Abeta40 levels, and total serum Abeta levels, but not serum Abeta42 levels and the ratio of Abeta42/Abeta40, after adjustment for age, gender, educational level, smoking history, alcohol consumption, body mass index (BMI) and comorbidities.	Capsaicin	32-41	amyloid beta precursor protein	Homo sapiens	134-139
25598150-8	2016	PEA only slightly enhanced 2-AG activation of TRPV1 channels, but significantly increased 2-AG-induced TRPV1 desensitization to capsaicin (IC50 from 0.75 +- 0.04 to 0.45 +- 0.02 muM, with PEA 2 muM).	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
25771490-8	2016	Moreover, the fasting serum apolipoprotein B and CGRP concentrations significantly increased in the capsaicin group (P &lt; 0.05).	Capsaicin	100-109	apolipoprotein B	Homo sapiens	28-44
25771490-8	2016	Moreover, the fasting serum apolipoprotein B and CGRP concentrations significantly increased in the capsaicin group (P &lt; 0.05).	Capsaicin	100-109	calcitonin related polypeptide alpha	Homo sapiens	49-53
26898566-0	2016	Variability in Capsaicin-stimulated Calcitonin Gene-related Peptide Release from Human Dental Pulp.	Capsaicin	15-24	calcitonin related polypeptide alpha	Homo sapiens	36-67
26898566-5	2016	Tooth slices from 36 patients were exposed to 60 mumol/L capsaicin to stimulate the release of calcitonin gene-related peptide (CGRP) from nerve terminals in the pulp.	Capsaicin	57-66	calcitonin related polypeptide alpha	Homo sapiens	95-126
26898566-5	2016	Tooth slices from 36 patients were exposed to 60 mumol/L capsaicin to stimulate the release of calcitonin gene-related peptide (CGRP) from nerve terminals in the pulp.	Capsaicin	57-66	calcitonin related polypeptide alpha	Homo sapiens	128-132
26525975-1	2016	Transient receptor transient receptor potential vanilloid 1 (TRPV1) is a Ca(2+)-permeable channel gated by oxidative stress and capsaicin (CAP) and modulated by melatonin (MEL) and capsazepine (CPZ).	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
26525975-1	2016	Transient receptor transient receptor potential vanilloid 1 (TRPV1) is a Ca(2+)-permeable channel gated by oxidative stress and capsaicin (CAP) and modulated by melatonin (MEL) and capsazepine (CPZ).	Capsaicin	139-142	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
27226186-26	2016	We conclude that curcumin exerts gastroprotective and hyperemic activities against experimental stress-induced gastric lesions by mechanism involving endogenous prostaglandins, NO, the neuropeptides such as CGRP released from capsaicin-sensitive afferent nerves and the activation of vanilloid TRPV1 receptors located on these sensory nerve terminals.	Capsaicin	226-235	calcitonin-related polypeptide alpha	Rattus norvegicus	207-211
26724373-9	2016	Both a CB1 antagonist (AM251) and a TRPV1 agonist (Capsaicin; CPS) increased the expression of a conditioned emotional response.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	36-41
26729265-2	2016	Whole-cell patch-clamp recordings of principal entorhinal cortex (EC) layers II/III neurons revealed that evoked inhibitory postsynaptic currents were depressed by application of the TRPV1 agonist capsaicin (CAP), accompanied by a change in the pair-pulse ratio (PPR).	Capsaicin	197-206	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	183-188
26729265-2	2016	Whole-cell patch-clamp recordings of principal entorhinal cortex (EC) layers II/III neurons revealed that evoked inhibitory postsynaptic currents were depressed by application of the TRPV1 agonist capsaicin (CAP), accompanied by a change in the pair-pulse ratio (PPR).	Capsaicin	208-211	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	183-188
27064319-4	2016	In order to detect the TRPV1-mediated responses in cultured DRG neurons, we monitored intracellular calcium responses to capsaicin, a TRPV1 agonist, with Fura-2.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
27064319-4	2016	In order to detect the TRPV1-mediated responses in cultured DRG neurons, we monitored intracellular calcium responses to capsaicin, a TRPV1 agonist, with Fura-2.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	134-139
26563747-8	2016	In contrast, when the calcium-calmodulin-dependent protein kinase II (CaMKII) was blocked with KN-93, the inhibitory effect of SKF 81297 on the capsaicin-activated current was greatly reduced, suggesting that activation of D1/D5 dopamine receptors may be preferentially linked to CaMKII activity.	Capsaicin	144-153	dopamine receptor D5	Homo sapiens	223-247
27348971-0	2016	Capsaicin induces metabolism of simvasatin in rat: involvement of upregulating expression of Ugt1a1.	Capsaicin	0-9	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	93-99
27348971-9	2016	In conclusion, chronic ingestion of CAP enhanced the expression level of Ugt1a1 in liver, causing the food -drug interaction and decrease in SV exposure in rats to a significant extent.	Capsaicin	36-39	UDP glucuronosyltransferase family 1 member A1	Rattus norvegicus	73-79
27068285-7	2016	Capsaicin injection increased functional connectivity in the mid-brain network and mediodorsal thalamic nucleus, hippocampus, and globus pallidus, which was significantly stronger in CAPS-MIA compared to CAPS-CON groups.	Capsaicin	0-9	calcium dependent secretion activator	Rattus norvegicus	183-187
26934446-5	2016	Capsaicin-evoked TRPV1 currents in dorsal root ganglion (DRG) neurons were examined by the patch-clamp technique.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
26756551-10	2016	Eact activation of the TRPV1 channel was severely attenuated by mutations disrupting the capsaicin-binding sites.	Capsaicin	89-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-28
26531834-1	2016	The purpose of this study was to determine the effect of regular ingestion of capsaicin-containing food that is easily available in everyday life on the latency of the swallowing response (LSR).	Capsaicin	78-87	lipolysis stimulated lipoprotein receptor	Homo sapiens	189-192
26898566-6	2016	Patient factors were analyzed for their effects on capsaicin-stimulated CGRP release using a mixed model analysis of variance.	Capsaicin	51-60	calcitonin related polypeptide alpha	Homo sapiens	72-76
26898566-7	2016	RESULTS: Approximately one third of the variability observed in capsaicin-evoked CGRP release was attributable to differences between individuals.	Capsaicin	64-73	calcitonin related polypeptide alpha	Homo sapiens	81-85
26898566-9	2016	Using a within-subject study design, a significant effect of capsaicin on CGRP release was observed.	Capsaicin	61-70	calcitonin related polypeptide alpha	Homo sapiens	74-78
26898566-10	2016	CONCLUSIONS: Capsaicin-stimulated CGRP release from dental pulp is highly variable between individuals.	Capsaicin	13-22	calcitonin related polypeptide alpha	Homo sapiens	34-38
27064319-5	2016	Long-term (4 h) treatment with glutamate receptor agonists (glutamate, quisqualate or DHPG) increased the proportion of neurons responding to capsaicin through activation of metabotropic glutamate receptor mGluR1, and only partially through the activation of mGluR5; engagement of these receptors was evident in neurons responding to allylisothiocyanate (AITC), a transient receptor potential ankyrin type 1 (TRPA1) agonist.	Capsaicin	142-151	glutamate receptor, metabotropic 1	Mus musculus	206-212
27064319-5	2016	Long-term (4 h) treatment with glutamate receptor agonists (glutamate, quisqualate or DHPG) increased the proportion of neurons responding to capsaicin through activation of metabotropic glutamate receptor mGluR1, and only partially through the activation of mGluR5; engagement of these receptors was evident in neurons responding to allylisothiocyanate (AITC), a transient receptor potential ankyrin type 1 (TRPA1) agonist.	Capsaicin	142-151	glutamate receptor, ionotropic, kainate 1	Mus musculus	259-265
27064319-5	2016	Long-term (4 h) treatment with glutamate receptor agonists (glutamate, quisqualate or DHPG) increased the proportion of neurons responding to capsaicin through activation of metabotropic glutamate receptor mGluR1, and only partially through the activation of mGluR5; engagement of these receptors was evident in neurons responding to allylisothiocyanate (AITC), a transient receptor potential ankyrin type 1 (TRPA1) agonist.	Capsaicin	142-151	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	364-407
27064319-5	2016	Long-term (4 h) treatment with glutamate receptor agonists (glutamate, quisqualate or DHPG) increased the proportion of neurons responding to capsaicin through activation of metabotropic glutamate receptor mGluR1, and only partially through the activation of mGluR5; engagement of these receptors was evident in neurons responding to allylisothiocyanate (AITC), a transient receptor potential ankyrin type 1 (TRPA1) agonist.	Capsaicin	142-151	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	409-414
26785164-5	2016	Variability in perceived bitterness of capsaicin and ethanol were significantly associated with TAS2R38 and TAS2R3/4/5 diplotypes.	Capsaicin	39-48	taste 2 receptor member 38	Homo sapiens	96-103
26785164-5	2016	Variability in perceived bitterness of capsaicin and ethanol were significantly associated with TAS2R38 and TAS2R3/4/5 diplotypes.	Capsaicin	39-48	taste 2 receptor member 3	Homo sapiens	96-102
26929329-6	2016	Sensory neuron ablation by neonatal capsaicin injection prevented perineural invasion (PNI), astrocyte activation, and neuronal damage, suggesting that sensory neurons convey inflammatory signals from Kras-induced pancreatic neoplasia to the CNS.	Capsaicin	36-45	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	201-205
26976969-5	2016	Recently, many research groups, including ours, found that capsaicin targets multiple signaling pathways, oncogenes and tumor-suppressor genes in various types of cancer models.	Capsaicin	59-68	TSC complex subunit 1	Homo sapiens	120-136
26907473-9	2016	Electrophysiology studies re-confirms acute H2O2 exposure activated TRPV1 in HEK293A and bovine aortic endothelial cells while establishing that H2O2 potentiate capsaicin-activated TRPV1 currents, whereas prolonged H2O2 exposure attenuated TRPV1 currents.	Capsaicin	161-170	TRPV1	Bos taurus	181-186
26907473-9	2016	Electrophysiology studies re-confirms acute H2O2 exposure activated TRPV1 in HEK293A and bovine aortic endothelial cells while establishing that H2O2 potentiate capsaicin-activated TRPV1 currents, whereas prolonged H2O2 exposure attenuated TRPV1 currents.	Capsaicin	161-170	TRPV1	Bos taurus	181-186
26635025-7	2016	5-HT injection enhanced 5-HT- and capsaicin-evoked calcium signals specifically in isolectin B4 (IB4)-negative neurons; signals were inhibited by a 5-HT2B/2C antagonist and PKCepsilon blocker.	Capsaicin	34-43	protein kinase C, epsilon	Mus musculus	173-183
26645885-0	2016	Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
26689735-2	2016	3T1AM also directly activates cold-sensitive transient receptor potential melastatin 8 (TRPM8) channels in human conjunctival epithelial cells (HCjEC) at constant temperature as well as reducing rises in IL-6 release induced by transient receptor potential vanilloid 1 (TRPV1) activation by capsaicin (CAP).	Capsaicin	291-300	transient receptor potential cation channel subfamily M member 8	Homo sapiens	88-93
26645885-5	2016	hTRPV1 currents activated by heat and capsaicin were inhibited by menthol, whereas hTRPM8 currents activated by cold and menthol were similarly inhibited by capsaicin.	Capsaicin	157-166	transient receptor potential cation channel subfamily M member 8	Homo sapiens	83-89
26645885-0	2016	Reciprocal effects of capsaicin and menthol on thermosensation through regulated activities of TRPV1 and TRPM8.	Capsaicin	22-31	transient receptor potential cation channel subfamily M member 8	Homo sapiens	105-110
26645885-1	2016	Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (&gt;42  C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity.	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
26645885-1	2016	Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (&gt;42  C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity.	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
26645885-1	2016	Transient receptor potential vanilloid 1 (TRPV1) is activated by elevated temperature (&gt;42  C), and it has been reported that cold temperature decreases capsaicin-induced TRPV1 activity.	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Homo sapiens	174-179
26645885-4	2016	We examined the effects of menthol on human (h)TRPV1 and of capsaicin on hTRPM8.	Capsaicin	60-69	transient receptor potential cation channel subfamily M member 8	Homo sapiens	73-79
26645885-5	2016	hTRPV1 currents activated by heat and capsaicin were inhibited by menthol, whereas hTRPM8 currents activated by cold and menthol were similarly inhibited by capsaicin.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-6
26973533-7	2016	Activation of TRPV4 also significantly potentiated capsaicin-evoked chemoreflex responses.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	14-19
26762784-4	2016	In our experiments, the TRPV1 agonist capsaicin evoked CGRP release and this was supressed by the TRPV1 antagonist capsazepine and by the opioid receptor agonist DAMGO.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
26795113-3	2016	These compounds were evaluated for antagonism of hTRPV1 activation by capsaicin and the ability to inhibit Ovine COX-1 and human recombinant COX-2 in vitro.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-55
26902776-4	2016	Increasing or decreasing Cdk5 activity in genetically engineered mice has severe consequences on TRPV1-mediated pain perception leading to altered capsaicin consumption and sensitivity to heat.	Capsaicin	147-156	cyclin-dependent kinase 5	Mus musculus	25-29
26902776-4	2016	Increasing or decreasing Cdk5 activity in genetically engineered mice has severe consequences on TRPV1-mediated pain perception leading to altered capsaicin consumption and sensitivity to heat.	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	97-102
26902776-6	2016	We performed detailed functional characterization by means of electrophysiological whole-cell and single-channel recordings as well as Ca(2+)-imaging and challenged recombinant rTRPV1 receptors with capsaicin, low pH, or heat.	Capsaicin	199-208	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	177-183
26762784-4	2016	In our experiments, the TRPV1 agonist capsaicin evoked CGRP release and this was supressed by the TRPV1 antagonist capsazepine and by the opioid receptor agonist DAMGO.	Capsaicin	38-47	calcitonin-related polypeptide alpha	Rattus norvegicus	55-59
26762784-4	2016	In our experiments, the TRPV1 agonist capsaicin evoked CGRP release and this was supressed by the TRPV1 antagonist capsazepine and by the opioid receptor agonist DAMGO.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
26621124-8	2016	Activation and inhibition of TRPV1 receptors (via capsaicin 1muM and capsazepine 10muM, respectively) did not influence basal synaptic transmission in CA1 and CA3 regions of control slices, however, capsaicin increased and capsazepine decreased synaptic transmission in both regions in tissues from epileptic animals.	Capsaicin	50-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
26621124-8	2016	Activation and inhibition of TRPV1 receptors (via capsaicin 1muM and capsazepine 10muM, respectively) did not influence basal synaptic transmission in CA1 and CA3 regions of control slices, however, capsaicin increased and capsazepine decreased synaptic transmission in both regions in tissues from epileptic animals.	Capsaicin	199-208	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
26360809-2	2016	These compounds were investigated for antagonism of hTRPV1 activation by capsaicin and acid in vitro.	Capsaicin	73-82	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-58
26718419-3	2016	We hypothesized that capsaicin induces satiety through the release of gastrointestinal peptides, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), from enteroendocrine cells in the small intestine.	Capsaicin	21-30	peptide YY	Homo sapiens	141-151
26718419-3	2016	We hypothesized that capsaicin induces satiety through the release of gastrointestinal peptides, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), from enteroendocrine cells in the small intestine.	Capsaicin	21-30	peptide YY	Homo sapiens	153-156
26718419-4	2016	OBJECTIVE: We investigate the effects of an intraduodenal capsaicin infusion (1.5 mg pure capsaicin) in healthy volunteers on hunger, satiety, and gastrointestinal symptoms and the release of GLP-1 and PYY.	Capsaicin	58-67	glucagon	Homo sapiens	192-197
26718419-3	2016	We hypothesized that capsaicin induces satiety through the release of gastrointestinal peptides, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), from enteroendocrine cells in the small intestine.	Capsaicin	21-30	glucagon	Homo sapiens	105-128
26718419-3	2016	We hypothesized that capsaicin induces satiety through the release of gastrointestinal peptides, such as glucagon-like peptide-1 (GLP-1) and peptide YY (PYY), from enteroendocrine cells in the small intestine.	Capsaicin	21-30	glucagon	Homo sapiens	130-135
26490461-1	2016	Some cation permeable ligand-gated ion channels, including the capsaicin-sensitive TRPV1, have been reported to exhibit a time-dependent increase in permeability to large inorganic cations during sustained activation, a phenomenon termed "pore dilation."	Capsaicin	63-72	transient receptor potential cation channel subfamily V member 1	Homo sapiens	83-88
26667415-9	2016	The activation of TRPV1 by capsaicin upregulated UCP2 expression via protein kinase A phosphorylation, thereby alleviating endothelial mitochondrial dysfunction and inhibiting mitochondrial ROS generation.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	18-23
26667415-9	2016	The activation of TRPV1 by capsaicin upregulated UCP2 expression via protein kinase A phosphorylation, thereby alleviating endothelial mitochondrial dysfunction and inhibiting mitochondrial ROS generation.	Capsaicin	27-36	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	49-53
26667415-10	2016	In vivo, dietary capsaicin supplementation enhanced coronary relaxation and prolonged the survival duration of HFD-fed ApoE(-/-) mice.	Capsaicin	17-26	apolipoprotein E	Mus musculus	119-123
26471418-5	2016	Activation of TRPV1 with capsaicin (100 nM) increased spontaneous EPSCs (sEPSCs) but inhibited ST-EPSCs.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
26738986-0	2016	Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca(2+) influx through transient receptor potential V1 (TRPV1) channels.	Capsaicin	41-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-126
26738986-0	2016	Tris-hydroxymethyl-aminomethane enhances capsaicin-induced intracellular Ca(2+) influx through transient receptor potential V1 (TRPV1) channels.	Capsaicin	41-50	transient receptor potential cation channel subfamily V member 1	Homo sapiens	128-133
26738986-5	2016	Notably, both capsaicin (1 muM) and pH 6.5 buffer elicited steep increases in the intracellular Ca(2+) concentration ([Ca(2+)]i), while treatment with THAM (pH 8.5) alone had no effect.	Capsaicin	14-23	latexin	Homo sapiens	27-30
26738986-6	2016	However, treatment with THAM (pH 8.5) following capsaicin application elicited a profound, long-lasting increase in [Ca(2+)]i that was completely inhibited by the TRPV1 antagonist capsazepine.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	163-168
26490461-3	2016	However, our experiments employing whole cell patch clamp photometry and single channel recordings to directly measure relative Ca(2+) current in TRPV1 expressing HEK293 cells show that relative Ca(2+) influx remains constant for the duration of capsaicin-evoked channel activation.	Capsaicin	246-255	transient receptor potential cation channel subfamily V member 1	Homo sapiens	146-151
26909384-8	2016	The data are different from our previous evidence, where TRPA1 agonizts AITC and CA and TRPV1 agonist capsaicin produced hyperalgesia for nearly 2 h and resulted in facilitation of these withdrawal reflexes (Tsagareli et al., 2010, 2013).	Capsaicin	102-111	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	57-62
26834613-1	2015	In a human fMRI study, it has been demonstrated that tasting and ingesting capsaicin activate the ventral part of the middle and posterior short gyri (M/PSG) of the insula which is known as the primary gustatory area, suggesting that capsaicin is recognized as a taste.	Capsaicin	75-84	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	153-156
26834613-1	2015	In a human fMRI study, it has been demonstrated that tasting and ingesting capsaicin activate the ventral part of the middle and posterior short gyri (M/PSG) of the insula which is known as the primary gustatory area, suggesting that capsaicin is recognized as a taste.	Capsaicin	234-243	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	153-156
26834613-6	2015	Group analyses with the regions activated by capsaicin revealed significant activations in the bilateral ASG and M/PSG.	Capsaicin	45-54	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	115-118
26834613-7	2015	The fMRI blood oxygenation level-dependent (BOLD) signals in response to capsaicin stimulation were significantly higher in ASG than in M/PSG regardless of the side.	Capsaicin	73-82	pregnancy specific beta-1-glycoprotein 5	Homo sapiens	138-141
26808812-8	2016	Intradermal injection of capsaicin, the pungent ingredient in hot chili peppers, produced equivalent hypersensitivity in NMNAT2+/- and WT mice receiving vehicle in lieu of paclitaxel.	Capsaicin	25-34	nicotinamide nucleotide adenylyltransferase 2	Mus musculus	121-127
26909384-8	2016	The data are different from our previous evidence, where TRPA1 agonizts AITC and CA and TRPV1 agonist capsaicin produced hyperalgesia for nearly 2 h and resulted in facilitation of these withdrawal reflexes (Tsagareli et al., 2010, 2013).	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	88-93
26746673-1	2016	BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable cation channel that is expressed on capsaicin-sensitive sensory neurons, endothelial and inflammatory cells.	Capsaicin	122-131	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	16-54
26625315-4	2016	Herein, we have tested the involvement of autophagy on the capsaicin mechanism of action on prostate cancer LNCaP and PC-3 cells.The results showed that capsaicin induced prostate cancer cell death in a time- and concentration-dependent manner, increased the levels of microtubule-associated protein light chain 3-II (LC3-II, a marker of autophagy) and the accumulation of the cargo protein p62 suggesting an autophagy blockage.	Capsaicin	153-162	nucleoporin 62	Homo sapiens	391-394
26719417-0	2016	Understanding TRPV1 activation by ligands: Insights from the binding modes of capsaicin and resiniferatoxin.	Capsaicin	78-87	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
26719417-4	2016	The recent cryo-electron microscopy structure of TRPV1 only provides a coarse characterization of the location of capsaicin (CAPS) and resiniferatoxin (RTX).	Capsaicin	114-123	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
26719417-4	2016	The recent cryo-electron microscopy structure of TRPV1 only provides a coarse characterization of the location of capsaicin (CAPS) and resiniferatoxin (RTX).	Capsaicin	125-129	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
26746673-1	2016	BACKGROUND: The transient receptor potential ankyrin 1 (TRPA1) is a calcium-permeable cation channel that is expressed on capsaicin-sensitive sensory neurons, endothelial and inflammatory cells.	Capsaicin	122-131	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	56-61
26516054-8	2016	Noteworthy, Whirlin expression significantly reduced TRPV1 degradation induced by prolonged exposure to capsaicin.	Capsaicin	104-113	whirlin	Rattus norvegicus	12-19
27771922-3	2016	In addition to the anti-inflammatory and analgesic properties of capsaicin largely recognized via, mainly, interaction with the TRPV1, the effects of capsaicin on different cell signalling pathways will be further discussed here.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	128-133
26884754-11	2016	Psychophysical studies with capsaicin are consistent with recent findings that have identified TRPV1 channel modulation by phosphorylation and interactions with membrane inositol phospholipids.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
26706937-1	2016	Effects of curcumin (turmeric) and capsaicin (red pepper) on hepatic fat accumulation and fetuin-A expression in rats fed high-fat diet (HFD) is aimed to be investigated.	Capsaicin	35-44	alpha-2-HS-glycoprotein	Rattus norvegicus	90-98
26706937-5	2016	Curcumin and capsaicin treatments significantly reduced hepatic fat accumulation and leptin levels; liver fetuin-A expression was decreased significantly by the curcumin treatment.	Capsaicin	13-22	leptin	Rattus norvegicus	85-91
26706937-6	2016	Curcumin and capsaicin treatments attenuated hepatic fat accumulation and increased leptin levels related to inflammation.	Capsaicin	13-22	leptin	Rattus norvegicus	84-90
26516054-8	2016	Noteworthy, Whirlin expression significantly reduced TRPV1 degradation induced by prolonged exposure to capsaicin.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	53-58
25854794-1	2016	BACKGROUND: Topical high-dose capsaicin acting on TRPV1 receptors and inducing an intraepidermal decrease in the small nerve fibre count is effective in treating neuropathic pain (NP).	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
26881438-6	2016	RESULTS: Capsaicin, a TRPV1 agonist, stimulates both the cough and swallowing reflexes.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
26559125-7	2016	AMG 334 dose-dependently prevented capsaicin-induced increases in dermal blood flow on days 2 and 4 postdosing.	Capsaicin	35-44	amelogenin X-linked	Homo sapiens	0-3
29537196-1	2016	The activity of TRPA1 and TRPV1 channels, their sensitivity to selective activators - allyl isothiocyanate (AITC) and capsaicin (Caps), especially their interaction were studied.	Capsaicin	118-127	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	16-21
29537196-7	2016	Further application of selective TRPA1 channel agonist (AITC) resulted in restoration of sensitivity to capsaicin TRPV1 channels ( resensitization TRPV1 channels).	Capsaicin	104-113	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	33-38
29537196-7	2016	Further application of selective TRPA1 channel agonist (AITC) resulted in restoration of sensitivity to capsaicin TRPV1 channels ( resensitization TRPV1 channels).	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	114-119
29537196-7	2016	Further application of selective TRPA1 channel agonist (AITC) resulted in restoration of sensitivity to capsaicin TRPV1 channels ( resensitization TRPV1 channels).	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	147-152
27656230-0	2016	Immunohistochemical expression of ghrelin in capsaicin-treated rat ovaries during the different developmental periods.	Capsaicin	45-54	ghrelin and obestatin prepropeptide	Rattus norvegicus	34-41
27656230-5	2016	The aim of this study was the localization and expression of ghrelin in the ovaries of rats treated with capsaicin during the postnatal development.	Capsaicin	105-114	ghrelin and obestatin prepropeptide	Rattus norvegicus	61-68
27078694-2	2016	Capsaicin stimulation of afferent fibres was also shown to result in the release of BDNF into the spinal cord.	Capsaicin	0-9	brain-derived neurotrophic factor	Rattus norvegicus	84-88
26648574-0	2016	Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
26648574-0	2016	Capsaicin enhances anti-proliferation efficacy of pirarubicin via activating TRPV1 and inhibiting PCNA nuclear translocation in 5637 cells.	Capsaicin	0-9	proliferating cell nuclear antigen	Homo sapiens	98-102
26648574-5	2016	Furthermore, activation of TRPV1 by capsaicin was shown to induce growth inhibition of 5637 cells in which TRPV1 was highly expressed, while the growth of T24 cells, which express TRPV1 at low levels, was not affected.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
26648574-5	2016	Furthermore, activation of TRPV1 by capsaicin was shown to induce growth inhibition of 5637 cells in which TRPV1 was highly expressed, while the growth of T24 cells, which express TRPV1 at low levels, was not affected.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
26648574-5	2016	Furthermore, activation of TRPV1 by capsaicin was shown to induce growth inhibition of 5637 cells in which TRPV1 was highly expressed, while the growth of T24 cells, which express TRPV1 at low levels, was not affected.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
26819760-7	2016	We found that 77.8% of the immepip-sensitized DRG neurons respond to the TRPV1 selective agonist capsaicin.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
27398080-6	2016	METHODS: We developed a flow through biosensor with human cells expressing both the TRPV1, a calcium ion channel which responds to capsaicin, and the fluorescent intracellular calcium ion reporter, YC3.6.	Capsaicin	131-140	transient receptor potential cation channel subfamily V member 1	Homo sapiens	84-89
26596174-4	2016	Internal perfusion of capsaicin-sensitive sensory neurons with GDP-betaS, substituted for GTP, blocks the ability of 8CPT-AM to increase AP firing, demonstrating that Epac-induced sensitization is G-protein dependent.	Capsaicin	22-31	Rap guanine nucleotide exchange factor 3	Rattus norvegicus	167-171
27078694-6	2016	Furthermore, intrathecal administration of exogenous BDNF not only produced mechanical hyperalgesia but also significantly blocked the inhibitory effect of capsaicin.	Capsaicin	156-165	brain-derived neurotrophic factor	Rattus norvegicus	53-57
26655809-10	2015	Mammalian TRPA1 is not activated by capsaicin, yet knockdown of the single predicted TRPA1-like gene (SmTRPA) in S. mansoni effectively abolishes capsaicin-induced responses in adult worms, suggesting that SmTRPA is required for capsaicin sensitivity in these parasites.	Capsaicin	146-155	transient receptor potential cation channel subfamily A member 1	Homo sapiens	85-90
28115879-2	2016	Capsaicin, one of several capsaicinoid compounds, is a potent TRPV1 agonist.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-67
28115879-2	2016	Capsaicin, one of several capsaicinoid compounds, is a potent TRPV1 agonist.	Capsaicin	26-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-67
27160991-0	2016	Capsaicin-Induced Death of Human Haematological Malignant Cell Lines Is Independent of TRPV1 Activation.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
27160991-1	2016	The effect of the plant-derived vanilloid, capsaicin (CAP), on the metabolic activity of THP-1, U266B1 and U937 hematological malignancy cells was determined.	Capsaicin	32-41	GLI family zinc finger 2	Homo sapiens	89-94
27160991-1	2016	The effect of the plant-derived vanilloid, capsaicin (CAP), on the metabolic activity of THP-1, U266B1 and U937 hematological malignancy cells was determined.	Capsaicin	43-52	GLI family zinc finger 2	Homo sapiens	89-94
26658875-5	2015	Our data show that GRP directly activates small-size capsaicin-sensitive DRG neurons, an effect that translates into transient calcium flux and membrane depolarization (~ 20 mV).	Capsaicin	53-62	gastrin releasing peptide	Homo sapiens	19-22
27160991-1	2016	The effect of the plant-derived vanilloid, capsaicin (CAP), on the metabolic activity of THP-1, U266B1 and U937 hematological malignancy cells was determined.	Capsaicin	54-57	GLI family zinc finger 2	Homo sapiens	89-94
27160991-8	2016	CAP inhibits the metabolic activity of malignant hematological cells through non-TRPV1-dependent mechanisms.	Capsaicin	0-3	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
26469307-0	2015	Phosphorylation of Capsaicinoid Derivatives Provides Highly Potent and Selective Inhibitors of the Transcription Factor STAT5b.	Capsaicin	19-31	signal transducer and activator of transcription 5B	Homo sapiens	120-126
26655809-10	2015	Mammalian TRPA1 is not activated by capsaicin, yet knockdown of the single predicted TRPA1-like gene (SmTRPA) in S. mansoni effectively abolishes capsaicin-induced responses in adult worms, suggesting that SmTRPA is required for capsaicin sensitivity in these parasites.	Capsaicin	146-155	transient receptor potential cation channel subfamily A member 1	Homo sapiens	85-90
25339153-3	2015	We investigated whether activation of TRP vanilloid (subtype 1) (TRPV1) channels by dietary capsaicin can, by ameliorating cardiac mitochondrial dysfunction, prevent high-salt diet-induced cardiac hypertrophy.	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
25339153-10	2015	Chronic dietary capsaicin increased cardiac mitochondrial sirtuin 3 expression, the proficiency of Complex I OXPHOS, ATP production and Complex I enzyme activity in a TRPV1-dependent manner.	Capsaicin	16-25	sirtuin 3	Mus musculus	58-67
25339153-10	2015	Chronic dietary capsaicin increased cardiac mitochondrial sirtuin 3 expression, the proficiency of Complex I OXPHOS, ATP production and Complex I enzyme activity in a TRPV1-dependent manner.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	167-172
25339153-11	2015	CONCLUSIONS AND IMPLICATIONS: TRPV1 activation by dietary capsaicin can antagonize high-salt diet-mediated cardiac lesions by ameliorating its deleterious effect on the proficiency of Complex I OXPHOS.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	30-35
26456648-10	2015	In our study, we identified new modulators of 5-HT3A receptors out of the classes of monoterpenes and vanilloid substances that frequently occur in various plants.	Capsaicin	102-111	5-hydroxytryptamine receptor 3A	Homo sapiens	46-52
26384954-10	2015	MCF-7 cells were treated with capsaicin at various concentrations (5 muM, 10 muM, and 20 muM) for 24 h. After capsaicin treatment, it was found that the number of breast CSC (%) decreased as the treatment concentration of capsaicin increased.	Capsaicin	30-39	latexin	Homo sapiens	69-72
26384954-10	2015	MCF-7 cells were treated with capsaicin at various concentrations (5 muM, 10 muM, and 20 muM) for 24 h. After capsaicin treatment, it was found that the number of breast CSC (%) decreased as the treatment concentration of capsaicin increased.	Capsaicin	30-39	latexin	Homo sapiens	77-80
26384954-10	2015	MCF-7 cells were treated with capsaicin at various concentrations (5 muM, 10 muM, and 20 muM) for 24 h. After capsaicin treatment, it was found that the number of breast CSC (%) decreased as the treatment concentration of capsaicin increased.	Capsaicin	30-39	latexin	Homo sapiens	77-80
26384954-15	2015	In addition, apoptotic cell death was caused when the breast CSC were treated with capsaicin at more than 10 muM.	Capsaicin	83-92	latexin	Homo sapiens	109-112
26464396-3	2015	Here, we found that activation of transient receptor potential vanilloid subtype 1 (TRPV1) by capsaicin increased rat saliva secretion both in vivo and ex vivo.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	34-82
26464396-3	2015	Here, we found that activation of transient receptor potential vanilloid subtype 1 (TRPV1) by capsaicin increased rat saliva secretion both in vivo and ex vivo.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-89
26464396-8	2015	In capsaicin-treated cells, ZO-1 and -2 single or double knockdown abolished, whereas their re-expression restored, the capsaicin-induced increase in paracellular permeability.	Capsaicin	3-12	tight junction protein 1	Rattus norvegicus	28-39
26464396-8	2015	In capsaicin-treated cells, ZO-1 and -2 single or double knockdown abolished, whereas their re-expression restored, the capsaicin-induced increase in paracellular permeability.	Capsaicin	120-129	tight junction protein 1	Rattus norvegicus	28-39
26464396-9	2015	Furthermore, TRPV1 activation increased RhoA activity, and inhibition of either RhoA or Rho kinase (ROCK) abolished the capsaicin-induced TER decrease as well as ZO-1 and -2 redistribution.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
26464396-9	2015	Furthermore, TRPV1 activation increased RhoA activity, and inhibition of either RhoA or Rho kinase (ROCK) abolished the capsaicin-induced TER decrease as well as ZO-1 and -2 redistribution.	Capsaicin	120-129	ras homolog family member A	Rattus norvegicus	40-44
26464396-9	2015	Furthermore, TRPV1 activation increased RhoA activity, and inhibition of either RhoA or Rho kinase (ROCK) abolished the capsaicin-induced TER decrease as well as ZO-1 and -2 redistribution.	Capsaicin	120-129	ras homolog family member A	Rattus norvegicus	80-84
26270588-6	2015	The capsaicin-induced current in TG neurons innervating the tongue was enhanced following TNBS treatment and was inhibited by local administration of neutralizing anti-Artn antibody to the tongue.	Capsaicin	4-13	artemin	Homo sapiens	168-172
26343294-4	2015	Capsaicin, which activates transient receptor potential vanilloid type 1 (TRPV1) receptors and increases mIPSC frequency in the DMV via an iGluR-mediated, heterosynaptic mechanism, was also applied to assess GABA release subsequent to capsaicin-stimulated glutamate release.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-72
26456642-1	2015	Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high Ca(2+) permeability, which functions as a polymodal nociceptor activated by heat, protons and several vanilloids, including capsaicin and anandamide.	Capsaicin	217-226	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
26456642-1	2015	Transient receptor potential vanilloid 1 (TRPV1) is a non-selective cation channel with high Ca(2+) permeability, which functions as a polymodal nociceptor activated by heat, protons and several vanilloids, including capsaicin and anandamide.	Capsaicin	217-226	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
26581770-6	2015	Importantly, the overexpression of Neurog1 increased the response of these neurons to capsaicin stimulation, a hallmark of mature functional nociceptive neurons.	Capsaicin	86-95	neurogenin 1	Homo sapiens	35-42
26343294-4	2015	Capsaicin, which activates transient receptor potential vanilloid type 1 (TRPV1) receptors and increases mIPSC frequency in the DMV via an iGluR-mediated, heterosynaptic mechanism, was also applied to assess GABA release subsequent to capsaicin-stimulated glutamate release.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	74-79
26360139-11	2015	When an ineffective dose of the TRPV1 receptor antagonist 6-IODO was used, the capsaicin-induced increase in the cardiac baroreflex response was abolished.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	32-37
26450532-5	2015	LC-injected GLT-1 siRNA impaired capsaicin-evoked release of LC glutamate and spinal noradrenaline, capsaicin-evoked LC neuronal activation, and NSIA.	Capsaicin	100-109	solute carrier family 1 member 2	Rattus norvegicus	12-17
26819932-3	2015	METHODS: Total antioxidant potential of capsaicin was evaluated using Ferric reducing ability of plasma (FRAP) assay.	Capsaicin	40-49	mechanistic target of rapamycin kinase	Homo sapiens	105-109
26450532-5	2015	LC-injected GLT-1 siRNA impaired capsaicin-evoked release of LC glutamate and spinal noradrenaline, capsaicin-evoked LC neuronal activation, and NSIA.	Capsaicin	33-42	solute carrier family 1 member 2	Rattus norvegicus	12-17
26578888-13	2015	Responses in some MEN significantly decreased after perfusion of TTX, low Ca(++)/high Mg(++) Krebs solution, capsaicin induced nerve defunctionalization and capsazepine indicating the involvement of TRPV1 expressing extrinsic mechanosensitive nerves.	Capsaicin	109-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
26114340-5	2015	In this review the focus is on the so called "capsaicin model" as a typical example of a target engagement biomarker used as a human model for the development of CGRP blocking therapeutics.	Capsaicin	46-55	calcitonin related polypeptide alpha	Homo sapiens	162-166
26114340-6	2015	By applying capsaicin onto the skin, TRPV1 channels are activated and a CGRP-mediated increase in dermal blood flow can be quantified with laser Doppler perfusion imaging.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
26114340-6	2015	By applying capsaicin onto the skin, TRPV1 channels are activated and a CGRP-mediated increase in dermal blood flow can be quantified with laser Doppler perfusion imaging.	Capsaicin	12-21	calcitonin related polypeptide alpha	Homo sapiens	72-76
26334010-10	2015	Our results suggest that the increase in P500 magnitude after capsaicin is mediated by facilitated mechanical nociceptive pathways.	Capsaicin	62-71	C-C motif chemokine ligand 1	Homo sapiens	41-45
25716421-0	2015	Single high-concentration capsaicin application prevents c-Fos expression in spinothalamic and postsynaptic dorsal column neurons after surgical incision.	Capsaicin	26-35	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	57-62
25716421-7	2015	This increase in c-Fos expression was significantly attenuated in animals in which a single high-concentration capsaicin injection was made intradermally at the incision site 24 h before the surgery.	Capsaicin	111-120	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	17-22
25978942-1	2015	BACKGROUND: Capsaicin specifically activates, and then gradually exhausts, the transient receptor potential vanilloid type 1 (TRPV1) receptor, a key receptor in neuropathic pain.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	126-131
26245821-5	2015	KEY FINDINGS: HLP (1, 0.5 and 0.1 mg/ear) resulted in a substantial reduction in skin thickness or tissue weight on all models tested, except for capsaicin-induced ear oedema, similar to dexamethasone (0.1 mg/ear) and/or indomethacin (0.5 mg/ear).	Capsaicin	146-155	cysteine rich protein 2	Mus musculus	14-17
26827596-5	2015	Capsaicin, an agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), has been shown to activate the peripheral sensory C-fibers.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-65
26827596-5	2015	Capsaicin, an agonist of Transient Receptor Potential Vanilloid 1 (TRPV1), has been shown to activate the peripheral sensory C-fibers.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
26827596-15	2015	By the same mechanism as that underlying the effect of ACE inhibitors, aural stimulation with capsaicin may reduce the incidence of aspiration pneumonia in patients with dysphagia.	Capsaicin	94-103	angiotensin I converting enzyme	Homo sapiens	55-58
25978942-8	2015	METHODS: Capsaicin .075% cream was applied to both halves of each participant"s upper lip, inducing pain via stimulation of the transient receptor potential vanilloid 1 (TRPV1, capsaicin) receptor, then removed after 5 minutes or when participants reported a burning pain of 8/10, whichever came first.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	170-175
25703814-1	2015	TRPV1 is a Ca2+ permeable channel and gated by noxious heat, oxidative stress and capsaicin (CAP).	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
26247812-2	2015	Capsaicin binds to the vanilloid receptor TRPV1, which plays a role in coordinating chemical and physical painful stimuli.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
26338963-4	2015	In this study, we found that Capsaicin induced an apoptotic cell death in PEL cells correlated with the inhibition of STAT3.	Capsaicin	29-38	signal transducer and activator of transcription 3	Homo sapiens	118-123
26338963-6	2015	By STAT3 de-phosphorylation, Capsaicin reduced the Mcl-1 expression level and this could represent one of the underlying mechanisms leading to the Capsaicin-mediated cell death and autophagy induction.	Capsaicin	29-38	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	51-56
26338963-6	2015	By STAT3 de-phosphorylation, Capsaicin reduced the Mcl-1 expression level and this could represent one of the underlying mechanisms leading to the Capsaicin-mediated cell death and autophagy induction.	Capsaicin	147-156	signal transducer and activator of transcription 3	Homo sapiens	3-8
26338963-6	2015	By STAT3 de-phosphorylation, Capsaicin reduced the Mcl-1 expression level and this could represent one of the underlying mechanisms leading to the Capsaicin-mediated cell death and autophagy induction.	Capsaicin	147-156	MCL1 apoptosis regulator, BCL2 family member	Homo sapiens	51-56
25703814-1	2015	TRPV1 is a Ca2+ permeable channel and gated by noxious heat, oxidative stress and capsaicin (CAP).	Capsaicin	93-96	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
26010461-4	2015	Here, we explored the role of TRP vanilloid 1 (TRPV1), a channel opened by capsaicin, heat, protons, and endovanilloids, in microglia.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	30-45
26010461-4	2015	Here, we explored the role of TRP vanilloid 1 (TRPV1), a channel opened by capsaicin, heat, protons, and endovanilloids, in microglia.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	47-52
26010461-5	2015	We found that application of capsaicin induced concentration-dependent migration in microglia derived from wild-type mice but not in those derived from TRPV1 knockout (TRPV1-KO) mice.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	168-173
26010461-6	2015	Capsaicin-induced microglial migration was significantly inhibited by co-application of the TRPV1 blocker SB366791 and the Ca(2+) chelator BAPTA-AM.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-97
26010461-11	2015	Capsaicin-induced microglial migration was inhibited by membrane-permeable antioxidants and MAPK inhibitors, suggesting that mitochondrial TRPV1 activation induced Ca(2+) -dependent production of ROS followed by MAPK activation, which correlated with an augmented migration of microglia.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	139-144
25359787-0	2015	The TRPV1 receptor agonist capsaicin is an ineffective bronchoprovocant in an experimental model of feline asthma.	Capsaicin	27-36	transient receptor potential channel vanilloid subfamily member-1	Felis catus	4-9
25359787-3	2015	We hypothesized that capsaicin, a transient receptor potential cation channel subfamily V member 1 agonist, would lead to dose-responsive increases in airway resistance as measured by ventilator-acquired pulmonary mechanics in experimentally asthmatic cats.	Capsaicin	21-30	transient receptor potential channel vanilloid subfamily member-1	Felis catus	34-98
26238178-7	2015	It has been revealed that intracellular Ca2+ increase responses evoked by the TRPV1 agonist capsaicin, the TRPA1 agonsits allyl isothiocyanate (AITC) and formaldehyde as well as the TRPM8 activator icilin were inhibited after SMase, MCD and myriocin incubation but the response to the TRPM3 agonist pregnenolon sulphate was not altered.	Capsaicin	92-101	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	78-83
25955385-8	2015	In addition, AYP evoked calcium influx in ~1.5% of cultured DRG neurons also sensitive to TRPV1 (capsaicin) and/or TRPA1 (AITC) agonists.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	90-95
26254243-7	2015	In voltage-clamp condition, a hyperpolarizing activated inward current sensitive to ZD7288 and capsaicin was significantly increased in neurons from Abeta-treated rats.	Capsaicin	95-104	amyloid beta precursor protein	Rattus norvegicus	149-154
26238178-9	2015	Besides the cell bodies, SMase also inhibited capsaicin- or AITC-evoked CGRP release from peripheral sensory nerve terminals, this provides the first evidence for the importance of lipid raft integrity in TRPV1 and TRPA1 gating on capsaicin-sensitive nerve terminals.	Capsaicin	231-240	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily A member 1	Cricetulus griseus	215-220
26485387-10	2015	Capsaicin stimulation of the pulp also significantly increased the Bax:Bcl-2 ratio and activated caspase-3 in the hippocampus (P&lt;.01), which was inhibited by ibuprofen pretreatment (P&lt;.05).	Capsaicin	0-9	BCL2 associated X, apoptosis regulator	Rattus norvegicus	67-70
26485387-10	2015	Capsaicin stimulation of the pulp also significantly increased the Bax:Bcl-2 ratio and activated caspase-3 in the hippocampus (P&lt;.01), which was inhibited by ibuprofen pretreatment (P&lt;.05).	Capsaicin	0-9	BCL2, apoptosis regulator	Rattus norvegicus	71-76
26485387-10	2015	Capsaicin stimulation of the pulp also significantly increased the Bax:Bcl-2 ratio and activated caspase-3 in the hippocampus (P&lt;.01), which was inhibited by ibuprofen pretreatment (P&lt;.05).	Capsaicin	0-9	caspase 3	Rattus norvegicus	97-106
26098441-7	2015	TRPA1 protein expression was significantly elevated in the vagina, and calcium transients evoked by mustard oil (TRPA1 ligand) or capsaicin (TRPV1 ligand) were significantly decreased in dorsal root ganglion from NVI mice, despite displaying increased depolarization-evoked calcium transients.	Capsaicin	130-139	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	0-5
26098441-7	2015	TRPA1 protein expression was significantly elevated in the vagina, and calcium transients evoked by mustard oil (TRPA1 ligand) or capsaicin (TRPV1 ligand) were significantly decreased in dorsal root ganglion from NVI mice, despite displaying increased depolarization-evoked calcium transients.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	141-146
26376721-11	2015	Additionally, we found that the number of capsaicin-responding neurons and the magnitude of evoked calcium response were markedly reduced in DRG neurons from Pirt (-/-) mice.	Capsaicin	42-51	phosphoinositide-interacting regulator of transient receptor potential channels	Mus musculus	158-162
26424893-12	2015	Significance statement: In this original work, it is shown for the first time that paclitaxel activates peripheral sensory and spinal neurons directly and sensitizes these cells to transient receptor potential vanilloid subtype 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species.	Capsaicin	247-256	transient receptor potential cation channel subfamily V member 1	Homo sapiens	181-229
26424893-12	2015	Significance statement: In this original work, it is shown for the first time that paclitaxel activates peripheral sensory and spinal neurons directly and sensitizes these cells to transient receptor potential vanilloid subtype 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species.	Capsaicin	247-256	transient receptor potential cation channel subfamily V member 1	Homo sapiens	231-236
26424893-12	2015	Significance statement: In this original work, it is shown for the first time that paclitaxel activates peripheral sensory and spinal neurons directly and sensitizes these cells to transient receptor potential vanilloid subtype 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species.	Capsaicin	247-256	toll like receptor 4	Homo sapiens	271-291
26424893-12	2015	Significance statement: In this original work, it is shown for the first time that paclitaxel activates peripheral sensory and spinal neurons directly and sensitizes these cells to transient receptor potential vanilloid subtype 1 (TRPV1)-mediated capsaicin responses via Toll-like receptor 4 (TLR4) in multiple species.	Capsaicin	247-256	toll like receptor 4	Homo sapiens	293-297
26378245-3	2015	Resiniferatoxin (RTX), like capsaicin, is a TRPV1 agonist but has greater potency.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Sus scrofa	44-49
25905588-5	2015	PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in the plantar skin after intraplantar administration of capsaicin (50 mul, 100 mug ml(-1)), an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cell accumulation.	Capsaicin	151-160	adenylate cyclase activating polypeptide 1	Mus musculus	0-5
26117090-10	2015	Activation of TRPV1 in the primary synoviocytes with capsaicin, a TRPV1 agonist, dose-dependently enhanced COX-2 transcription.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
26117090-10	2015	Activation of TRPV1 in the primary synoviocytes with capsaicin, a TRPV1 agonist, dose-dependently enhanced COX-2 transcription.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-71
26117090-10	2015	Activation of TRPV1 in the primary synoviocytes with capsaicin, a TRPV1 agonist, dose-dependently enhanced COX-2 transcription.	Capsaicin	53-62	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	107-112
26175075-8	2015	The pivotal role of TNF-alpha in neurogenic inflammation was further supported by the findings that incubation DRG with TNF-alpha mimicked the increased excitability of DRG neurons induced by capsaicin injection, and that TNF-alpha application enhanced cutaneous vasodilation in the hind paws induced by antidromic electrical stimulation of dorsal roots.	Capsaicin	192-201	tumor necrosis factor	Rattus norvegicus	20-29
26175075-8	2015	The pivotal role of TNF-alpha in neurogenic inflammation was further supported by the findings that incubation DRG with TNF-alpha mimicked the increased excitability of DRG neurons induced by capsaicin injection, and that TNF-alpha application enhanced cutaneous vasodilation in the hind paws induced by antidromic electrical stimulation of dorsal roots.	Capsaicin	192-201	tumor necrosis factor	Rattus norvegicus	120-129
26175075-8	2015	The pivotal role of TNF-alpha in neurogenic inflammation was further supported by the findings that incubation DRG with TNF-alpha mimicked the increased excitability of DRG neurons induced by capsaicin injection, and that TNF-alpha application enhanced cutaneous vasodilation in the hind paws induced by antidromic electrical stimulation of dorsal roots.	Capsaicin	192-201	tumor necrosis factor	Rattus norvegicus	120-129
26093270-0	2015	Capsaicin attenuates LPS-induced inflammatory cytokine production by upregulation of LXRalpha.	Capsaicin	0-9	nuclear receptor subfamily 1 group H member 3	Homo sapiens	85-93
26093270-1	2015	Here, we investigated the role of LXRalpha in capsaicin mediated anti-inflammatory effects.	Capsaicin	46-55	nuclear receptor subfamily 1 group H member 3	Homo sapiens	34-42
26093270-2	2015	Results revealed that capsaicin inhibits LPS-induced IL-1beta, IL-6 and TNF-alpha production in a time- and dose-dependent manner.	Capsaicin	22-31	interleukin 1 beta	Homo sapiens	53-61
26093270-2	2015	Results revealed that capsaicin inhibits LPS-induced IL-1beta, IL-6 and TNF-alpha production in a time- and dose-dependent manner.	Capsaicin	22-31	interleukin 6	Homo sapiens	63-67
26093270-2	2015	Results revealed that capsaicin inhibits LPS-induced IL-1beta, IL-6 and TNF-alpha production in a time- and dose-dependent manner.	Capsaicin	22-31	tumor necrosis factor	Homo sapiens	72-81
26093270-3	2015	Moreover, capsaicin increases LXRalpha expression through PPARgamma pathway.	Capsaicin	10-19	nuclear receptor subfamily 1 group H member 3	Homo sapiens	30-38
26093270-3	2015	Moreover, capsaicin increases LXRalpha expression through PPARgamma pathway.	Capsaicin	10-19	peroxisome proliferator activated receptor gamma	Homo sapiens	58-67
26093270-4	2015	Inhibition of LXRalpha activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1beta, IL-6 and TNF-alpha production.	Capsaicin	79-88	nuclear receptor subfamily 1 group H member 3	Homo sapiens	14-22
26093270-4	2015	Inhibition of LXRalpha activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1beta, IL-6 and TNF-alpha production.	Capsaicin	79-88	interleukin 1 beta	Homo sapiens	104-112
26093270-4	2015	Inhibition of LXRalpha activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1beta, IL-6 and TNF-alpha production.	Capsaicin	79-88	interleukin 6	Homo sapiens	114-118
26093270-4	2015	Inhibition of LXRalpha activation by siRNA diminished the inhibitory action of capsaicin on LPS-induced IL-1beta, IL-6 and TNF-alpha production.	Capsaicin	79-88	tumor necrosis factor	Homo sapiens	123-132
26093270-5	2015	Additionally, LXRalpha siRNA abrogated the inhibitory action of capsaicin on p65 NF-kappaB protein expression.	Capsaicin	64-73	nuclear receptor subfamily 1 group H member 3	Homo sapiens	14-22
26093270-6	2015	Thus, we propose that the anti-inflammatory effects of capsaicin are LXRalpha dependent, and LXRalpha may potentially link the capsaicin mediated PPARgamma activation and NF-kappaB inhibition in LPS-induced inflammatory response.	Capsaicin	55-64	nuclear receptor subfamily 1 group H member 3	Homo sapiens	69-77
26093270-6	2015	Thus, we propose that the anti-inflammatory effects of capsaicin are LXRalpha dependent, and LXRalpha may potentially link the capsaicin mediated PPARgamma activation and NF-kappaB inhibition in LPS-induced inflammatory response.	Capsaicin	127-136	nuclear receptor subfamily 1 group H member 3	Homo sapiens	93-101
26093270-6	2015	Thus, we propose that the anti-inflammatory effects of capsaicin are LXRalpha dependent, and LXRalpha may potentially link the capsaicin mediated PPARgamma activation and NF-kappaB inhibition in LPS-induced inflammatory response.	Capsaicin	127-136	peroxisome proliferator activated receptor gamma	Homo sapiens	146-155
26364309-0	2015	Anoctamin-1 Cl(-) channels in nociception: activation by an N-aroylaminothiazole and capsaicin and inhibition by T16A[inh]-A01.	Capsaicin	85-94	anoctamin 1, calcium activated chloride channel	Mus musculus	0-11
26364309-9	2015	To not disrupt TRPV1 carried-Ca(2+) activation of ANO1 in DRG neurons, ANO1 modulation of capsaicin-induced action potentials was measured by perforated-patch (Amphotericin-B) current-clamp technique.	Capsaicin	90-99	anoctamin 1, calcium activated chloride channel	Mus musculus	71-75
26364309-16	2015	ANO1-inhibition attenuated capsaicin-triggering of action potentials and capsaicin-induced nocifensive behaviors.	Capsaicin	27-36	anoctamin 1, calcium activated chloride channel	Mus musculus	0-4
26364309-16	2015	ANO1-inhibition attenuated capsaicin-triggering of action potentials and capsaicin-induced nocifensive behaviors.	Capsaicin	73-82	anoctamin 1, calcium activated chloride channel	Mus musculus	0-4
26048309-7	2015	Moreover, the VBC, as well as, each one of the B vitamins independently reduced the capsaicin-induced calcium responses in HEK 293 cells transiently transfected with the human TRPV1 channels.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	176-181
25421590-8	2015	After patient education and before application of capsaicin patch, a significant reduction of three levels on the NRS was observed.	Capsaicin	50-59	sphingolipid transporter 1 (putative)	Homo sapiens	114-117
25943423-4	2015	Functional blockade of TRPV1-positive nociceptors by high-concentration capsaicin (verified by loss of heat pain) significantly reduced pain ratings to high frequency stimulation by 47% (P &lt; 0.001), homotopic pain-long-term potentiation by 71% (P &lt; 0.01), heterotopic pain-long-term potentiation by 92% (P &lt; 0.001) and the area of secondary hyperalgesia by 76% (P &lt; 0.001).	Capsaicin	72-81	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-28
25905588-5	2015	PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in the plantar skin after intraplantar administration of capsaicin (50 mul, 100 mug ml(-1)), an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cell accumulation.	Capsaicin	151-160	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	10-14
25905588-5	2015	PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in the plantar skin after intraplantar administration of capsaicin (50 mul, 100 mug ml(-1)), an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cell accumulation.	Capsaicin	151-160	adenylate cyclase activating polypeptide 1	Mus musculus	32-37
25905588-5	2015	PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in the plantar skin after intraplantar administration of capsaicin (50 mul, 100 mug ml(-1)), an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cell accumulation.	Capsaicin	151-160	adenylate cyclase activating polypeptide 1 receptor 1	Mus musculus	45-49
25905588-5	2015	PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in the plantar skin after intraplantar administration of capsaicin (50 mul, 100 mug ml(-1)), an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cell accumulation.	Capsaicin	151-160	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	205-245
25905588-5	2015	PACAP and PAC1 mRNA, as well as PACAP-38 and PAC1 protein expression, significantly increased in the plantar skin after intraplantar administration of capsaicin (50 mul, 100 mug ml(-1)), an agonist of the transient receptor potential vanilloid 1 (TRPV1) receptor, evoking chiefly neurogenic inflammation without inflammatory cell accumulation.	Capsaicin	151-160	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	247-252
25905588-7	2015	Capsaicin-induced neurogenic paw edema, but not CFA-evoked non-neurogenic swelling, was significantly smaller in PACAP-deficient mice throughout a 24-hour period.	Capsaicin	0-9	adenylate cyclase activating polypeptide 1	Mus musculus	113-118
26084409-3	2015	The specificity of DSM action on TRPV1 was further confirmed by its inhibition of capsaicin-induced intracellular calcium increases in dorsal root ganglion neurons.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	33-38
26084409-14	2015	DSM also reduced the capsaicin-evoked TRPV1 ionic current in DRG neuronal primary culture from 83 +- 11% to 41 +- 8% of the initial response to capsaicin only.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	38-43
26116630-0	2015	Translational Pharmacodynamics of Calcitonin Gene-Related Peptide Monoclonal Antibody LY2951742 in a Capsaicin-Induced Dermal Blood Flow Model.	Capsaicin	101-110	calcitonin related polypeptide alpha	Homo sapiens	34-65
26197883-15	2015	Perivagal capsaicin application and pretreatment with devazepide prevented CCK-induced pronociception and CeA NR2B phosphorylation.	Capsaicin	10-19	cholecystokinin	Rattus norvegicus	75-78
26116630-3	2015	Inhibition of capsaicin-induced DBF in nonhuman primates, measured with laser Doppler imaging, was dose dependent and sustained for at least 29 days after a single intravenous injection of the CGRP antibody.	Capsaicin	14-23	calcitonin related polypeptide alpha	Homo sapiens	193-197
26197883-15	2015	Perivagal capsaicin application and pretreatment with devazepide prevented CCK-induced pronociception and CeA NR2B phosphorylation.	Capsaicin	10-19	glutamate ionotropic receptor NMDA type subunit 2B	Rattus norvegicus	110-114
25754030-1	2015	The heat- and capsaicin-sensitive transient receptor potential vanilloid 1 ion channel (TRPV1) is regulated by plasma membrane phosphoinositides.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
25754030-5	2015	We conclude that PI(4,5)P2 and potentially its precursor PI(4)P are positive cofactors for TRPV1, acting via direct interaction with the channel, and their depletion by Ca(2+)-induced activation of phospholipase Cdelta isoforms (PLCdelta) limits channel activity during capsaicin-induced desensitization.	Capsaicin	270-279	transient receptor potential cation channel subfamily V member 1	Homo sapiens	91-96
26047020-10	2015	The capsaicin group also demonstrated a significant reduction (P &lt; 0.05) in the metastatic burden compared to the controls, which correlated to a reduction in p27(Kip) (1) expression and neuroendocrine differentiation in prostate tumors.	Capsaicin	4-13	cyclin-dependent kinase inhibitor 1B	Mus musculus	162-165
26047020-10	2015	The capsaicin group also demonstrated a significant reduction (P &lt; 0.05) in the metastatic burden compared to the controls, which correlated to a reduction in p27(Kip) (1) expression and neuroendocrine differentiation in prostate tumors.	Capsaicin	4-13	calcium and integrin binding 1 (calmyrin)	Mus musculus	166-169
26205659-8	2015	The involvement of CGRP and NK1 receptors suggests that cathodal CIV is the result of CGRP and SP released through activated capsaicin-sensitive fibers.	Capsaicin	125-134	calcitonin-related polypeptide alpha	Rattus norvegicus	19-23
26205659-8	2015	The involvement of CGRP and NK1 receptors suggests that cathodal CIV is the result of CGRP and SP released through activated capsaicin-sensitive fibers.	Capsaicin	125-134	calcitonin-related polypeptide alpha	Rattus norvegicus	86-90
26047020-13	2015	CONCLUSION: The following study provides evidence supporting the safety and chemopreventive effects of capsaicin in the TRAMP model.	Capsaicin	103-112	dermatopontin	Mus musculus	120-125
26054320-4	2015	Specific inhibitors of TRPA1 (HC- 030031) and a specific activator of TRPV1 (capsaicin) were used to block or activate TRPA1 and TRPV1, respectively.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
26054320-4	2015	Specific inhibitors of TRPA1 (HC- 030031) and a specific activator of TRPV1 (capsaicin) were used to block or activate TRPA1 and TRPV1, respectively.	Capsaicin	77-86	transient receptor potential cation channel subfamily A member 1	Homo sapiens	119-124
26054320-4	2015	Specific inhibitors of TRPA1 (HC- 030031) and a specific activator of TRPV1 (capsaicin) were used to block or activate TRPA1 and TRPV1, respectively.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	129-134
26320055-16	2015	PCW significantly inhibited capsaicin-induced calcium influx in HEK293T-TRPV1 cells.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	72-77
26255724-0	2015	Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.	Capsaicin	78-87	sirtuin 1	Homo sapiens	0-9
26255724-0	2015	Sirtuin 1 (SIRT1) Deacetylase Activity and NAD+/NADH Ratio Are Imperative for Capsaicin-Mediated Programmed Cell Death.	Capsaicin	78-87	sirtuin 1	Homo sapiens	11-16
26255724-4	2015	In MRC-5 human fetal lung cells, capsaicin augmented silent mating type information regulation 1 (SIRT1) deacetylase activity and the intracellular NAD(+)/NADH ratio, decreasing acetylation of p53 and inducing autophagy.	Capsaicin	33-42	sirtuin 1	Homo sapiens	53-96
26255724-4	2015	In MRC-5 human fetal lung cells, capsaicin augmented silent mating type information regulation 1 (SIRT1) deacetylase activity and the intracellular NAD(+)/NADH ratio, decreasing acetylation of p53 and inducing autophagy.	Capsaicin	33-42	sirtuin 1	Homo sapiens	98-103
26255724-4	2015	In MRC-5 human fetal lung cells, capsaicin augmented silent mating type information regulation 1 (SIRT1) deacetylase activity and the intracellular NAD(+)/NADH ratio, decreasing acetylation of p53 and inducing autophagy.	Capsaicin	33-42	tumor protein p53	Homo sapiens	193-196
26255724-5	2015	In contrast, capsaicin decreased the intracellular NAD(+)/NADH ratio, possibly through inhibition of tumor-associated NADH oxidase (tNOX), and diminished SIRT1 expression leading to enhanced p53 acetylation and apoptosis.	Capsaicin	13-22	sirtuin 1	Homo sapiens	154-159
26255724-5	2015	In contrast, capsaicin decreased the intracellular NAD(+)/NADH ratio, possibly through inhibition of tumor-associated NADH oxidase (tNOX), and diminished SIRT1 expression leading to enhanced p53 acetylation and apoptosis.	Capsaicin	13-22	tumor protein p53	Homo sapiens	191-194
26255724-6	2015	Moreover, SIRT1 depletion by RNA interference attenuated capsaicin-induced apoptosis in A549 cancer cells and autophagy in MRC-5 cells, suggesting a vital role for SIRT1 in capsaicin-mediated cell death.	Capsaicin	57-66	sirtuin 1	Homo sapiens	10-15
26255724-6	2015	Moreover, SIRT1 depletion by RNA interference attenuated capsaicin-induced apoptosis in A549 cancer cells and autophagy in MRC-5 cells, suggesting a vital role for SIRT1 in capsaicin-mediated cell death.	Capsaicin	57-66	sirtuin 1	Homo sapiens	164-169
26255724-6	2015	Moreover, SIRT1 depletion by RNA interference attenuated capsaicin-induced apoptosis in A549 cancer cells and autophagy in MRC-5 cells, suggesting a vital role for SIRT1 in capsaicin-mediated cell death.	Capsaicin	173-182	sirtuin 1	Homo sapiens	10-15
26255724-6	2015	Moreover, SIRT1 depletion by RNA interference attenuated capsaicin-induced apoptosis in A549 cancer cells and autophagy in MRC-5 cells, suggesting a vital role for SIRT1 in capsaicin-mediated cell death.	Capsaicin	173-182	sirtuin 1	Homo sapiens	164-169
26054303-0	2015	Development of nNOS-positive neurons in the rat sensory ganglia after capsaicin treatment.	Capsaicin	70-79	nitric oxide synthase 1	Rattus norvegicus	15-19
26054303-2	2015	The percentage of nNOS-immunoreactive (IR) neurons decreased after capsaicin treatment in all studied ganglia in first 20 days of life, from 55.4% to 36.9% in the Th2 DRG, from 54.6% to 26.1% in the L4 DRG and from 37.1% to 15.0% in the NG.	Capsaicin	67-76	nitric oxide synthase 1	Rattus norvegicus	18-22
26054303-5	2015	Approximately 90% of the sensory nNOS-IR neurons bound to IB4 in the DRG and approximately 80% in the NG in capsaicin-treated and vehicle-treated rats.	Capsaicin	108-117	nitric oxide synthase 1	Rattus norvegicus	33-37
26054303-6	2015	In 10-day-old rats, a large number of nNOS-IR neurons also expressed TrkA, and the proportion of nNOS(+)/TrkA(+) neurons was larger in the capsaicin-treated rats compared with the vehicle-treated animals.	Capsaicin	139-148	nitric oxide synthase 1	Rattus norvegicus	38-42
26054303-6	2015	In 10-day-old rats, a large number of nNOS-IR neurons also expressed TrkA, and the proportion of nNOS(+)/TrkA(+) neurons was larger in the capsaicin-treated rats compared with the vehicle-treated animals.	Capsaicin	139-148	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	69-73
26054303-6	2015	In 10-day-old rats, a large number of nNOS-IR neurons also expressed TrkA, and the proportion of nNOS(+)/TrkA(+) neurons was larger in the capsaicin-treated rats compared with the vehicle-treated animals.	Capsaicin	139-148	nitric oxide synthase 1	Rattus norvegicus	97-101
26054303-6	2015	In 10-day-old rats, a large number of nNOS-IR neurons also expressed TrkA, and the proportion of nNOS(+)/TrkA(+) neurons was larger in the capsaicin-treated rats compared with the vehicle-treated animals.	Capsaicin	139-148	neurotrophic receptor tyrosine kinase 1	Rattus norvegicus	105-109
25932689-7	2015	Furthermore, intradermal capsaicin, menthol and TTA-A2 were used for desensitisation of TRPV1, TRPM8, and T-type calcium (Cav3.2) channels, respectively.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
25903105-5	2015	This down-regulation corresponded to reduced sensitivity to 100 nM capsaicin in vitro (IC50 = 230 +- 20 nM, 76 +- 4.4% wild-type capsaicin responders vs. 56.9 +- 4.7% HDAC4 cKO responders) and to reduced thermal hypersensitivity in the complete Freund"s adjuvant (CFA) model of inflammatory pain (1.3-1.4-fold improvement over wild-type controls; n = 5-12, in 2 separate experiments).	Capsaicin	67-76	histone deacetylase 4	Mus musculus	167-172
26055306-12	2015	CONCLUSIONS: Decreased expression of TRPV1 and associated neuropeptide release contributed to the impaired capsaicin-induced vasodilation in diabetic mesenteric arteries.	Capsaicin	107-116	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-42
26170176-1	2015	The TRPV1 cation channel is a polymodal nociceptor that is activated by heat and ligands such as capsaicin and is highly sensitive to changes in extracellular pH.	Capsaicin	97-106	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
26170176-2	2015	In the body core, where temperature is usually stable and capsaicin is normally absent, H(+) released in response to ischemia, tissue injury, or inflammation is the best-known endogenous TRPV1 agonist, activating the channel to mediate pain and vasodilation.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	187-192
26011134-0	2015	Capsaicin alleviates abnormal intestinal motility through regulation of enteric motor neurons and MLCK activity: Relevance to intestinal motility disorders.	Capsaicin	0-9	myosin light chain kinase	Rattus norvegicus	98-102
26011134-9	2015	Capsaicin significantly increased myosin light chain kinase (MLCK) expression and myosin phosphorylation extent in jejunal segments of constipation-prominent rats and significantly decreased MLCK expression and myosin phosphorylation extent in jejunal segments of diarrhea-prominent rats.	Capsaicin	0-9	myosin light chain kinase	Rattus norvegicus	34-59
26011134-9	2015	Capsaicin significantly increased myosin light chain kinase (MLCK) expression and myosin phosphorylation extent in jejunal segments of constipation-prominent rats and significantly decreased MLCK expression and myosin phosphorylation extent in jejunal segments of diarrhea-prominent rats.	Capsaicin	0-9	myosin light chain kinase	Rattus norvegicus	61-65
26011134-9	2015	Capsaicin significantly increased myosin light chain kinase (MLCK) expression and myosin phosphorylation extent in jejunal segments of constipation-prominent rats and significantly decreased MLCK expression and myosin phosphorylation extent in jejunal segments of diarrhea-prominent rats.	Capsaicin	0-9	myosin light chain kinase	Rattus norvegicus	191-195
26011134-10	2015	CONCLUSION: In summary, capsaicin alleviates abnormal intestinal motility through regulating enteric motor neurons and MLCK activity, which is beneficial for the treatment of gastrointestinal motility disorders.	Capsaicin	24-33	myosin light chain kinase	Rattus norvegicus	119-123
26244735-5	2015	Unexpectedly, we found that virtually full restitution of the AD1 sequence is required to reinstate channel expression and responses to capsaicin, temperature, and voltage.	Capsaicin	136-145	amyloid beta precursor protein	Homo sapiens	62-65
25888600-2	2015	Recent studies have shown a metabolic role of capsaicin that may be mediated via the transient receptor potential vanilloid type-1 (TRPV1) channel.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	85-130
25888600-2	2015	Recent studies have shown a metabolic role of capsaicin that may be mediated via the transient receptor potential vanilloid type-1 (TRPV1) channel.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	132-137
25932689-7	2015	Furthermore, intradermal capsaicin, menthol and TTA-A2 were used for desensitisation of TRPV1, TRPM8, and T-type calcium (Cav3.2) channels, respectively.	Capsaicin	25-34	transient receptor potential cation channel subfamily M member 8	Homo sapiens	95-100
25932689-7	2015	Furthermore, intradermal capsaicin, menthol and TTA-A2 were used for desensitisation of TRPV1, TRPM8, and T-type calcium (Cav3.2) channels, respectively.	Capsaicin	25-34	calcium voltage-gated channel subunit alpha1 H	Homo sapiens	122-128
26021808-8	2015	In vitro experiments revealed that prolonged exposure to SP could indeed sensitize capsaicin-evoked currents in both cultured neurons and TRPV1-transfected human embryonic kidney (HEK) cells, a mechanism that involved TRPV1 ubiquitination and subsequent accumulation at the plasma membrane.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	138-143
26224542-6	2015	In DRG neurons nociception can result from TRPV1 activation by capsaicin or LPA.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
26208267-6	2015	In [Ca2+]i measurement study, application of TRPV1 agonists, capsaicin and camphor, elicited a [Ca2+]i rise in mESC-CMs, the effect of which was abolished by TRPV1-shRNA.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-50
26208267-6	2015	In [Ca2+]i measurement study, application of TRPV1 agonists, capsaicin and camphor, elicited a [Ca2+]i rise in mESC-CMs, the effect of which was abolished by TRPV1-shRNA.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	158-163
26283923-5	2015	Application of the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin to meninges dramatically increased firing whereas the amplitudes and shapes of spikes remained essentially unchanged.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	19-59
26283923-5	2015	Application of the transient receptor potential vanilloid 1 (TRPV1) agonist capsaicin to meninges dramatically increased firing whereas the amplitudes and shapes of spikes remained essentially unchanged.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
26283923-12	2015	Thus, the persistent activation of nociceptors in capsaicin-sensitive nerve fibers shown here may be involved in trigeminal pain signaling and plasticity along with the release of migraine-related neuropeptides from TRPV1 positive neurons.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	216-221
26194846-1	2015	The receptor channel TRPV1 (Transient Receptor Potential Vanilloid 1) is expressed by primary afferent sensory neurons of the pain pathway, where it functions as a sensor of noxious heat and various chemicals, including eicosanoids, capsaicin, protons and peptide toxins.	Capsaicin	233-242	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-26
26194846-1	2015	The receptor channel TRPV1 (Transient Receptor Potential Vanilloid 1) is expressed by primary afferent sensory neurons of the pain pathway, where it functions as a sensor of noxious heat and various chemicals, including eicosanoids, capsaicin, protons and peptide toxins.	Capsaicin	233-242	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-68
26194846-4	2015	Here, we combined the use of concatemeric constructs harboring mutated binding sites with patch-clamp recordings in order to determine the stoichiometry for TRPV1 activation through the vanilloid binding site and the outer-pore domain by capsaicin and protons, respectively.	Capsaicin	186-195	transient receptor potential cation channel subfamily V member 1	Homo sapiens	157-162
26194846-4	2015	Here, we combined the use of concatemeric constructs harboring mutated binding sites with patch-clamp recordings in order to determine the stoichiometry for TRPV1 activation through the vanilloid binding site and the outer-pore domain by capsaicin and protons, respectively.	Capsaicin	238-247	transient receptor potential cation channel subfamily V member 1	Homo sapiens	157-162
26021808-8	2015	In vitro experiments revealed that prolonged exposure to SP could indeed sensitize capsaicin-evoked currents in both cultured neurons and TRPV1-transfected human embryonic kidney (HEK) cells, a mechanism that involved TRPV1 ubiquitination and subsequent accumulation at the plasma membrane.	Capsaicin	83-92	transient receptor potential cation channel subfamily V member 1	Homo sapiens	218-223
25387448-0	2015	Cerebral Networks Linked to Itch-related Sensations Induced by Histamine and Capsaicin.	Capsaicin	77-86	itchy E3 ubiquitin protein ligase	Homo sapiens	28-32
25864613-1	2015	Capsaicin is a potent inducer of apoptosis in tumourreceptor potential vanilloid 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-82
25864613-1	2015	Capsaicin is a potent inducer of apoptosis in tumourreceptor potential vanilloid 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	84-89
25864613-4	2015	The IC50 obtained proved to be cytotoxic for all three cell lines; however, in the cells treated with Capsaicin both active caspase-3 and nuclear fragmentation were present.	Capsaicin	102-111	caspase 3	Homo sapiens	124-133
25387448-1	2015	This functional magnetic resonance imaging (fMRI) study explored the central nervous processing of itch induced by histamine and capsaicin, delivered via inactivated cowhage spicules, and the influence of low-dose naltrexone.	Capsaicin	129-138	itchy E3 ubiquitin protein ligase	Homo sapiens	99-103
25366550-0	2015	A human capsaicin model to quantitatively assess salivary CGRP secretion.	Capsaicin	8-17	calcitonin related polypeptide alpha	Homo sapiens	58-62
24706047-7	2015	All non-peptidergic and a third of peptidergic alpha7 nAChR-bearing nociceptors expressed TRPV1, a capsaicin-sensitive noxious stimulus transducer.	Capsaicin	99-108	cholinergic receptor nicotinic beta 1 subunit	Rattus norvegicus	54-59
24706047-7	2015	All non-peptidergic and a third of peptidergic alpha7 nAChR-bearing nociceptors expressed TRPV1, a capsaicin-sensitive noxious stimulus transducer.	Capsaicin	99-108	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	90-95
25366550-1	2015	BACKGROUND: Capsaicin induces the release of calcitonin gene-related peptide (CGRP) via the transient receptor potential channel V1 (TRPV1).	Capsaicin	12-21	calcitonin related polypeptide alpha	Homo sapiens	45-76
25366550-1	2015	BACKGROUND: Capsaicin induces the release of calcitonin gene-related peptide (CGRP) via the transient receptor potential channel V1 (TRPV1).	Capsaicin	12-21	calcitonin related polypeptide alpha	Homo sapiens	78-82
25366550-1	2015	BACKGROUND: Capsaicin induces the release of calcitonin gene-related peptide (CGRP) via the transient receptor potential channel V1 (TRPV1).	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-131
25366550-1	2015	BACKGROUND: Capsaicin induces the release of calcitonin gene-related peptide (CGRP) via the transient receptor potential channel V1 (TRPV1).	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Homo sapiens	133-138
25366550-2	2015	The CGRP response after capsaicin application on the tongue might reflect the "activation state" of the trigeminal nerve, since trigeminal CGRP-containing vesicles are depleted on capsaicin application.	Capsaicin	24-33	calcitonin related polypeptide alpha	Homo sapiens	4-8
25366550-2	2015	The CGRP response after capsaicin application on the tongue might reflect the "activation state" of the trigeminal nerve, since trigeminal CGRP-containing vesicles are depleted on capsaicin application.	Capsaicin	24-33	calcitonin related polypeptide alpha	Homo sapiens	139-143
25366550-2	2015	The CGRP response after capsaicin application on the tongue might reflect the "activation state" of the trigeminal nerve, since trigeminal CGRP-containing vesicles are depleted on capsaicin application.	Capsaicin	180-189	calcitonin related polypeptide alpha	Homo sapiens	4-8
26111701-5	2015	The in vitro effects of AngII, AT2R agonist C21, and Nerve growth factor (NGF) were measured on neurite lengths; AngII, NGF and EMA401 effects on expression of p38 and p42/44 MAPK were measured using quantitative immunofluorescence, and on capsaicin responses using calcium imaging.	Capsaicin	240-249	mitogen-activated protein kinase 14	Homo sapiens	160-163
25994559-8	2015	Capsaicin significantly inhibited the early adipogenic differentiation, lipogenesis and maturation of adipocytes with concomitant repression of PPARgamma, C/EBPalpha, FABP4 and SCD-1.	Capsaicin	0-9	peroxisome proliferator activated receptor gamma	Homo sapiens	144-153
25994559-8	2015	Capsaicin significantly inhibited the early adipogenic differentiation, lipogenesis and maturation of adipocytes with concomitant repression of PPARgamma, C/EBPalpha, FABP4 and SCD-1.	Capsaicin	0-9	CCAAT enhancer binding protein alpha	Homo sapiens	155-165
25994559-8	2015	Capsaicin significantly inhibited the early adipogenic differentiation, lipogenesis and maturation of adipocytes with concomitant repression of PPARgamma, C/EBPalpha, FABP4 and SCD-1.	Capsaicin	0-9	fatty acid binding protein 4	Homo sapiens	167-172
25994559-8	2015	Capsaicin significantly inhibited the early adipogenic differentiation, lipogenesis and maturation of adipocytes with concomitant repression of PPARgamma, C/EBPalpha, FABP4 and SCD-1.	Capsaicin	0-9	stearoyl-CoA desaturase	Homo sapiens	177-182
26053297-0	2015	Structural mechanism underlying capsaicin binding and activation of the TRPV1 ion channel.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
26053297-1	2015	Capsaicin bestows spiciness by activating TRPV1 channel with exquisite potency and selectivity.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
26053297-6	2015	Capsaicin stabilizes TRPV1"s open state by "pull-and-contact" interactions between the vanillyl group and the S4-S5 linker.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-26
25576467-3	2015	TRPV1 is also activated by vanilloids, such as capsaicin, and endogenous neurolipins, e.g. N-arachidonoyl dopamine (NADA) and N-oleoyl dopamine (OLDA).	Capsaicin	47-56	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
26552144-2	2015	On this basis, the regulation action of capsaicin, one main ingredient from chili pepper, on TRPV1 channel was further explored by using confocal microscope.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	93-98
25846502-0	2015	Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice.	Capsaicin	27-36	mitogen-activated protein kinase 1	Mus musculus	104-107
25846502-0	2015	Cancer-promoting effect of capsaicin on DMBA/TPA-induced skin tumorigenesis by modulating inflammation, Erk and p38 in mice.	Capsaicin	27-36	mitogen-activated protein kinase 14	Mus musculus	112-115
25846502-6	2015	Mechanistic study found that inflammation-related factors cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were highly elevated by pretreatment with capsaicin, suggesting an inflammation-dependent mechanism.	Capsaicin	168-177	prostaglandin-endoperoxide synthase 2	Mus musculus	58-74
25846502-6	2015	Mechanistic study found that inflammation-related factors cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were highly elevated by pretreatment with capsaicin, suggesting an inflammation-dependent mechanism.	Capsaicin	168-177	prostaglandin-endoperoxide synthase 2	Mus musculus	76-81
25846502-6	2015	Mechanistic study found that inflammation-related factors cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS) were highly elevated by pretreatment with capsaicin, suggesting an inflammation-dependent mechanism.	Capsaicin	168-177	nitric oxide synthase 2, inducible	Mus musculus	87-118
25846502-7	2015	Furthermore, mice that were administered capsaicin exhibited significant up-regulation of phosphorylation of nuclear factor kappaB (NF-kappaB), Erk and p38 but had no effect on JNK.	Capsaicin	41-50	mitogen-activated protein kinase 1	Mus musculus	144-147
25846502-7	2015	Furthermore, mice that were administered capsaicin exhibited significant up-regulation of phosphorylation of nuclear factor kappaB (NF-kappaB), Erk and p38 but had no effect on JNK.	Capsaicin	41-50	mitogen-activated protein kinase 14	Mus musculus	152-155
25846502-8	2015	Thus, our results indicated that inflammation, Erk and P38 collectively played a crucial role in cancer-promoting effect of capsaicin on carcinogen-induced skin cancer in mice.	Capsaicin	124-133	mitogen-activated protein kinase 1	Mus musculus	47-50
25846502-8	2015	Thus, our results indicated that inflammation, Erk and P38 collectively played a crucial role in cancer-promoting effect of capsaicin on carcinogen-induced skin cancer in mice.	Capsaicin	124-133	mitogen-activated protein kinase 14	Mus musculus	55-58
25967571-6	2015	Activation of TRPV1 using capsaicin (1 microM) enhanced LTP induction in CA1 region in non-epileptic rats.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
25967571-6	2015	Activation of TRPV1 using capsaicin (1 microM) enhanced LTP induction in CA1 region in non-epileptic rats.	Capsaicin	26-35	carbonic anhydrase 1	Rattus norvegicus	73-76
26111701-12	2015	AngII mediated sensitization of capsaicin responses was not observed in the presence of MAP kinase inhibitor PD98059, and the kinase inhibitor staurosporine.	Capsaicin	32-41	angiotensinogen	Homo sapiens	0-5
26113985-1	2015	Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are found not only on nociceptive sensory neurons, but also in a range of other tissues.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-170
26113985-1	2015	Capsaicin, the phytochemical responsible for the spiciness of peppers, has the potential to modulate metabolism via activation of transient receptor potential vanilloid 1 (TRPV1) receptors, which are found not only on nociceptive sensory neurons, but also in a range of other tissues.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	172-177
26113985-6	2015	Capsaicin-mediated activation of TRPV1-expressing neurons in the gastrointestinal tract promotes sympathetically mediated stimulation of brown fat, raising metabolic rate.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	33-38
25855514-8	2015	The folic acid-enriched diet, fed to T+E2-treated mice, increased voiding frequency in response to intravesicular capsaicin infusion and increased mRNA abundance of the capsaicin-sensitive cation channel transient receptor potential vanilloid subfamily member 1 (Trpv1) in L6 and S1 dorsal root ganglia (DRG) neurons.	Capsaicin	169-178	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	263-268
25618378-4	2015	The results showed that the lowest limit of detection of this biosensor to capsaicin was 1x10(-13) mol/L and the change rate of response current was the highest at the concentration of 9x10(-13) mol/L, indicating that the capsaicin receptor was saturated at this point.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	222-240
25843413-5	2015	In this study, we examined the hippocampal effects of co-administrating WIN55-212-2 and capsaicin, which are CB1 and TRPV1 agonists, respectively, on the induction of LTP in the dentate gyrus (DG) of rats.	Capsaicin	88-97	cannabinoid receptor 1	Rattus norvegicus	109-112
25843413-5	2015	In this study, we examined the hippocampal effects of co-administrating WIN55-212-2 and capsaicin, which are CB1 and TRPV1 agonists, respectively, on the induction of LTP in the dentate gyrus (DG) of rats.	Capsaicin	88-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	117-122
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	Capsaicin	222-231	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	136-141
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	Capsaicin	222-231	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-151
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	Capsaicin	233-236	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	136-141
25858491-4	2015	Using the perforated patch-clamp recording technique, our study demonstrated a distinct positive interaction occurring abruptly between TRPA1 and TRPV1 when they were activated simultaneously by their respective agonists, capsaicin (Cap) and allyl isothiocyanate (AITC), at near-threshold concentrations in these neurons.	Capsaicin	233-236	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	146-151
26041925-6	2015	NGF treatment evoked sustained increases in peripheral and central TRPV1 activity, as demonstrated by increased capsaicin-evoked nocifensive responses, increased calcitonin gene-related peptide release from hindpaw skin biopsies, and increased capsaicin-evoked inward current and membrane expression of TRPV1 protein in dorsal root ganglia neurons.	Capsaicin	112-121	nerve growth factor	Homo sapiens	0-3
25914087-13	2015	SIGNIFICANCE: Our results demonstrate the involvement of capsaicin-sensitive sensory nerves and neutral endopeptidases in LPS-induced BHR of the human bronchi, associated with an upregulation of TRPV1 and release of NKA.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	195-200
25914087-13	2015	SIGNIFICANCE: Our results demonstrate the involvement of capsaicin-sensitive sensory nerves and neutral endopeptidases in LPS-induced BHR of the human bronchi, associated with an upregulation of TRPV1 and release of NKA.	Capsaicin	57-66	tachykinin precursor 1	Homo sapiens	216-219
26041925-6	2015	NGF treatment evoked sustained increases in peripheral and central TRPV1 activity, as demonstrated by increased capsaicin-evoked nocifensive responses, increased calcitonin gene-related peptide release from hindpaw skin biopsies, and increased capsaicin-evoked inward current and membrane expression of TRPV1 protein in dorsal root ganglia neurons.	Capsaicin	112-121	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
26041925-6	2015	NGF treatment evoked sustained increases in peripheral and central TRPV1 activity, as demonstrated by increased capsaicin-evoked nocifensive responses, increased calcitonin gene-related peptide release from hindpaw skin biopsies, and increased capsaicin-evoked inward current and membrane expression of TRPV1 protein in dorsal root ganglia neurons.	Capsaicin	244-253	nerve growth factor	Homo sapiens	0-3
25997690-3	2015	By modifying the FAAzos to resemble capsaicin, we prepare a series of photolipids targeting the Vanilloid Receptor 1 (TRPV1), a non-selective cation channel known for its role in nociception.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
25704235-1	2015	Red pepper and its major pungent principle, capsaicin (CAP), have been shown to be effective anti-obesity agents by reducing energy intake, enhancing energy metabolism, decreasing serum triacylglycerol content, and inhibiting adipogenesis via activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1).	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	261-325
25704235-1	2015	Red pepper and its major pungent principle, capsaicin (CAP), have been shown to be effective anti-obesity agents by reducing energy intake, enhancing energy metabolism, decreasing serum triacylglycerol content, and inhibiting adipogenesis via activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1).	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	327-332
25704235-1	2015	Red pepper and its major pungent principle, capsaicin (CAP), have been shown to be effective anti-obesity agents by reducing energy intake, enhancing energy metabolism, decreasing serum triacylglycerol content, and inhibiting adipogenesis via activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1).	Capsaicin	55-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	261-325
25704235-1	2015	Red pepper and its major pungent principle, capsaicin (CAP), have been shown to be effective anti-obesity agents by reducing energy intake, enhancing energy metabolism, decreasing serum triacylglycerol content, and inhibiting adipogenesis via activation of the transient receptor potential cation channel subfamily V member 1 (TRPV1).	Capsaicin	55-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	327-332
25712904-7	2015	Notably, the excitation of isolated MNCs during hypertonicity is mediated by the activation of a capsaicin-insensitive cation channel that MNCs express as an N-terminal variant of the transient receptor potential vanilloid 1 (Trpv1) channel.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	184-224
25712904-7	2015	Notably, the excitation of isolated MNCs during hypertonicity is mediated by the activation of a capsaicin-insensitive cation channel that MNCs express as an N-terminal variant of the transient receptor potential vanilloid 1 (Trpv1) channel.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	226-231
25929448-7	2015	During the activation by its agonist capsaicin, the cation inward influx through TRPV1 channels and the whole-cell current significantly decreased after TRPV1-overexpressed HEK293 cells or dorsal root ganglion (DRG) neurons were pre-treated with thalidomide for 20 minutes.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
25929448-7	2015	During the activation by its agonist capsaicin, the cation inward influx through TRPV1 channels and the whole-cell current significantly decreased after TRPV1-overexpressed HEK293 cells or dorsal root ganglion (DRG) neurons were pre-treated with thalidomide for 20 minutes.	Capsaicin	37-46	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-158
27227029-1	2015	Capsaicin, a selective activator of the chemo- and heat-sensitive transient receptor potential (TRP) V1 cation channel, has characteristic feature of causing long-term functional and structural impairment of neural elements supplied by TRPV1/capsaicin receptor.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	236-241
27227029-1	2015	Capsaicin, a selective activator of the chemo- and heat-sensitive transient receptor potential (TRP) V1 cation channel, has characteristic feature of causing long-term functional and structural impairment of neural elements supplied by TRPV1/capsaicin receptor.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	242-260
27227029-6	2015	Furthermore, strong evidence suggests that central presynaptic nerve terminals of TRPV1-expressing cutaneous, thoracic and abdominal visceral receptors are activated by innocuous warmth stimuli and capsaicin.	Capsaicin	198-207	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	82-87
25937016-1	2015	A series of alpha-substituted acetamide derivatives of previously reported 2-(3-fluoro-4-methylsulfonamidophenyl)propanamide leads (1, 2) were investigated for antagonism of hTRPV1 activation by capsaicin.	Capsaicin	195-204	transient receptor potential cation channel subfamily V member 1	Homo sapiens	174-180
25850459-4	2015	In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 4 antagonized capsaicin-induced Ca(2+) influx, with an IC50 value of 4.6 nM.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	5-10
25850459-4	2015	In a TRPV1 functional assay, using cells expressing recombinant human TRPV1 channels, 4 antagonized capsaicin-induced Ca(2+) influx, with an IC50 value of 4.6 nM.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
25869100-4	2015	Capsaicin treatment induced GSK-3beta by inhibiting its phosphorylation and further activated APC and Axin multicomplex, leading to the proteasomal degradation of beta-catenin.	Capsaicin	0-9	catenin beta 1	Homo sapiens	163-175
25869100-5	2015	Expression of TCF-1 and beta-catenin-responsive proteins, c-Myc and cyclin D1 also decreased in response to capsaicin treatment.	Capsaicin	108-117	transcription factor 7	Homo sapiens	14-19
25869100-5	2015	Expression of TCF-1 and beta-catenin-responsive proteins, c-Myc and cyclin D1 also decreased in response to capsaicin treatment.	Capsaicin	108-117	MYC proto-oncogene, bHLH transcription factor	Homo sapiens	58-63
25869100-5	2015	Expression of TCF-1 and beta-catenin-responsive proteins, c-Myc and cyclin D1 also decreased in response to capsaicin treatment.	Capsaicin	108-117	catenin beta 1	Homo sapiens	24-36
25869100-2	2015	In the present study, we evaluated the effect of capsaicin on beta-catenin/TCF signaling.	Capsaicin	49-58	catenin beta 1	Homo sapiens	62-74
25869100-5	2015	Expression of TCF-1 and beta-catenin-responsive proteins, c-Myc and cyclin D1 also decreased in response to capsaicin treatment.	Capsaicin	108-117	cyclin D1	Homo sapiens	68-77
25869100-6	2015	Pre-treatment of cells with MG-132 blocked capsaicin-mediated proteasomal degradation of beta-catenin.	Capsaicin	43-52	catenin beta 1	Homo sapiens	89-101
25869100-2	2015	In the present study, we evaluated the effect of capsaicin on beta-catenin/TCF signaling.	Capsaicin	49-58	hepatocyte nuclear factor 4 alpha	Homo sapiens	75-78
25869100-7	2015	To establish the involvement of beta-catenin in capsaicin-induced apoptosis, cells were treated with LiCl or SB415286, inhibitors of GSK-3beta.	Capsaicin	48-57	catenin beta 1	Homo sapiens	32-44
25869100-3	2015	In a concentration and time-dependent study, we observed that capsaicin treatment inhibits the activation of dishevelled (Dsh) protein DvI-1 in L3.6PL, PanC-1 and MiaPaCa-2 pancreatic cancer cells.	Capsaicin	62-71	dishevelled segment polarity protein 1 pseudogene 1	Homo sapiens	122-125
25869100-8	2015	Our results reveal that capsaicin treatment suppressed LiCl or SB415286-mediated activation of beta-catenin signaling.	Capsaicin	24-33	catenin beta 1	Homo sapiens	95-107
25869100-4	2015	Capsaicin treatment induced GSK-3beta by inhibiting its phosphorylation and further activated APC and Axin multicomplex, leading to the proteasomal degradation of beta-catenin.	Capsaicin	0-9	glycogen synthase kinase 3 beta	Homo sapiens	28-37
25869100-9	2015	Our results further showed that capsaicin blocked nuclear translocation of beta-catenin, TCF-1 and p-STAT-3 (Tyr705).	Capsaicin	32-41	catenin beta 1	Homo sapiens	75-87
25869100-9	2015	Our results further showed that capsaicin blocked nuclear translocation of beta-catenin, TCF-1 and p-STAT-3 (Tyr705).	Capsaicin	32-41	transcription factor 7	Homo sapiens	89-94
25869100-4	2015	Capsaicin treatment induced GSK-3beta by inhibiting its phosphorylation and further activated APC and Axin multicomplex, leading to the proteasomal degradation of beta-catenin.	Capsaicin	0-9	axin 1	Homo sapiens	102-106
25869100-9	2015	Our results further showed that capsaicin blocked nuclear translocation of beta-catenin, TCF-1 and p-STAT-3 (Tyr705).	Capsaicin	32-41	signal transducer and activator of transcription 3	Homo sapiens	101-107
25869100-10	2015	The immunoprecipitation results indicated that capsaicin treatment reduced the interaction of beta-catenin and TCF-1 in the nucleus.	Capsaicin	47-56	catenin beta 1	Homo sapiens	94-106
25869100-10	2015	The immunoprecipitation results indicated that capsaicin treatment reduced the interaction of beta-catenin and TCF-1 in the nucleus.	Capsaicin	47-56	transcription factor 7	Homo sapiens	111-116
25869100-11	2015	Moreover, capsaicin treatment significantly decreased the phosphorylation of STAT-3 at Tyr705.	Capsaicin	10-19	signal transducer and activator of transcription 3	Homo sapiens	77-83
25869100-12	2015	Interestingly, STAT-3 over expression or STAT-3 activation by IL-6, significantly increased the levels of beta-catenin and attenuated the effects of capsaicin in inhibiting beta-catenin signaling.	Capsaicin	149-158	signal transducer and activator of transcription 3	Homo sapiens	15-21
25869100-12	2015	Interestingly, STAT-3 over expression or STAT-3 activation by IL-6, significantly increased the levels of beta-catenin and attenuated the effects of capsaicin in inhibiting beta-catenin signaling.	Capsaicin	149-158	signal transducer and activator of transcription 3	Homo sapiens	41-47
25869100-12	2015	Interestingly, STAT-3 over expression or STAT-3 activation by IL-6, significantly increased the levels of beta-catenin and attenuated the effects of capsaicin in inhibiting beta-catenin signaling.	Capsaicin	149-158	interleukin 6	Homo sapiens	62-66
25869100-12	2015	Interestingly, STAT-3 over expression or STAT-3 activation by IL-6, significantly increased the levels of beta-catenin and attenuated the effects of capsaicin in inhibiting beta-catenin signaling.	Capsaicin	149-158	catenin beta 1	Homo sapiens	173-185
25869100-13	2015	Finally, capsaicin mediated inhibition of orthotopic tumor growth was associated with inhibition of beta-catenin/TCF-1 signaling.	Capsaicin	9-18	catenin beta 1	Homo sapiens	100-112
25743251-7	2015	PTZ and CAP+PTZ administrations increased intracellular free Ca(2+) concentrations, TRPV1 current densities, apoptosis, caspase 3 and 9 values although the values were reduced by IRTX and CPZ treatments.	Capsaicin	8-11	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-89
25869100-13	2015	Finally, capsaicin mediated inhibition of orthotopic tumor growth was associated with inhibition of beta-catenin/TCF-1 signaling.	Capsaicin	9-18	transcription factor 7	Homo sapiens	113-118
25743251-7	2015	PTZ and CAP+PTZ administrations increased intracellular free Ca(2+) concentrations, TRPV1 current densities, apoptosis, caspase 3 and 9 values although the values were reduced by IRTX and CPZ treatments.	Capsaicin	8-11	caspase 3	Rattus norvegicus	120-129
25869100-14	2015	Taken together, our results suggest that capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.	Capsaicin	41-50	catenin beta 1	Homo sapiens	130-142
25869100-14	2015	Taken together, our results suggest that capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.	Capsaicin	41-50	catenin beta 1	Homo sapiens	180-192
25869100-14	2015	Taken together, our results suggest that capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.	Capsaicin	41-50	hepatocyte nuclear factor 4 alpha	Homo sapiens	193-196
25869100-14	2015	Taken together, our results suggest that capsaicin-induced apoptosis in pancreatic cancer cells was associated with inhibition of beta-catenin signaling due to the dissociation of beta-catenin/TCF-1 complex and the process was orchestrated by STAT-3.	Capsaicin	41-50	signal transducer and activator of transcription 3	Homo sapiens	243-249
25594427-9	2015	CT327 inhibited capsaicin responses, indicating action at the nerve growth factor-TrkA-TRPV1 pathway.	Capsaicin	16-25	neurotrophic receptor tyrosine kinase 1	Homo sapiens	82-86
25876645-9	2015	The present study suggests capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-kappaB, p53, and target genes associated with apoptosis.	Capsaicin	27-36	nuclear factor kappa B subunit 1	Homo sapiens	185-194
25876645-9	2015	The present study suggests capsaicin and DIM work synergistically to inhibit cell proliferation and induce apoptosis in colorectal cancer through modulating transcriptional activity of NF-kappaB, p53, and target genes associated with apoptosis.	Capsaicin	27-36	tumor protein p53	Homo sapiens	196-199
25594427-9	2015	CT327 inhibited capsaicin responses, indicating action at the nerve growth factor-TrkA-TRPV1 pathway.	Capsaicin	16-25	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
25377933-0	2015	Characterizing the PK/PD relationship for inhibition of capsaicin-induced dermal vasodilatation by MK-3207, an oral calcitonin gene related peptide receptor antagonist.	Capsaicin	56-65	calcitonin related polypeptide alpha	Homo sapiens	116-147
25377933-3	2015	In the model, CGRP release is provoked after dermal capsaicin application, by activating transient receptor potential vanilloid-type-1 (TRPV1) receptors at peripheral sensory nerves.	Capsaicin	52-61	calcitonin related polypeptide alpha	Homo sapiens	14-18
25377933-3	2015	In the model, CGRP release is provoked after dermal capsaicin application, by activating transient receptor potential vanilloid-type-1 (TRPV1) receptors at peripheral sensory nerves.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-134
25377933-3	2015	In the model, CGRP release is provoked after dermal capsaicin application, by activating transient receptor potential vanilloid-type-1 (TRPV1) receptors at peripheral sensory nerves.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	136-141
25645682-4	2015	Acute neurogenic edema and inflammatory cell recruitment were induced by smearing the TRPA1 agonist mustard oil (5%) or the TRPV1 activator capsaicin (2.5%) on the mouse ear.	Capsaicin	140-149	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	124-129
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	97-106	AKT serine/threonine kinase 1	Homo sapiens	26-29
26018271-1	2015	OBJECTIVE: To investigate the role of capsaicin in regulating permeation of P-gp substrate rhodamine 123 (R123) across the jejunum, ileum and colon membranes of rats.	Capsaicin	38-47	phosphoglycolate phosphatase	Rattus norvegicus	76-80
26018271-6	2015	CONCLUSION: Capsaicin can affect the transport of R123 and CF across rat jejunal membranes, and this effect is shows an obvious intestine segment-related difference probably because of the different distribution of P-gp or tight junction in the intestines.	Capsaicin	12-21	phosphoglycolate phosphatase	Rattus norvegicus	215-219
26018271-7	2015	This finding suggests that capsaicin is a weak P-gp inhibitor and an improver of mucous membrane channels.	Capsaicin	27-36	phosphoglycolate phosphatase	Rattus norvegicus	47-51
25734989-1	2015	TRPV1 is a nociceptive ion channel activated by polymodal stimuli such as capsaicin, proton, and noxious heat.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
25734989-4	2015	Although the mechanisms of hypersensitivity of TRPV1 to capsaicin are well studied, the phosphorylation residues that contribute to hypersensitivity to heat or acid have not been identified.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	47-52
25734989-6	2015	In heterologous systems, TRPV1 S502 and S800, but not T704, are known to be involved in hypersensitivity to capsaicin after the application of phorbol myristate acetate (PMA), a PKC agonist.	Capsaicin	108-117	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-30
25734989-10	2015	In sensory neurons expressing mutated TRPV1, we found that alanine mutation of S800 commonly attenuates PMA-induced hypersensitivity to capsaicin, heat, and acid.	Capsaicin	136-145	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	38-43
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	97-106	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	184-209
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	97-106	protein tyrosine kinase 2 beta	Homo sapiens	217-233
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	97-106	AKT serine/threonine kinase 1	Homo sapiens	235-238
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	97-106	mechanistic target of rapamycin kinase	Homo sapiens	240-269
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	97-106	mechanistic target of rapamycin kinase	Homo sapiens	271-275
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	124-133	AKT serine/threonine kinase 1	Homo sapiens	26-29
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	124-133	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	184-209
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	124-133	protein tyrosine kinase 2 beta	Homo sapiens	217-233
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	124-133	AKT serine/threonine kinase 1	Homo sapiens	235-238
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	124-133	mechanistic target of rapamycin kinase	Homo sapiens	240-269
25933112-8	2015	Moreover, the decrease in AKT and S6 phosphorylation induced by 5-FU was effectively reversed by capsaicin, indicating that capsaicin inhibits 5-FU-induced autophagy by activating the phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway in CCA cells.	Capsaicin	124-133	mechanistic target of rapamycin kinase	Homo sapiens	271-275
25407627-4	2015	c-Fos expression and the phosphorylation of ERK were induced by the intraoral application of capsaicin and by electrical stimulation of the inferior alveolar nerve (IAN), respectively.	Capsaicin	93-102	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	0-5
25963558-7	2015	Importantly, capsaicin preferentially inhibited the enzyme activity of NOX and induced severe ROS accumulation in K-ras-transformed cells compared with parental E6E7 cells.	Capsaicin	13-22	KRAS proto-oncogene, GTPase	Homo sapiens	114-119
25963558-8	2015	Furthermore, capsaicin effectively inhibited cell proliferation, prevented invasiveness of K-ras-transformed pancreatic cancer cells, and caused minimum toxicity to parental E6E7 cells.	Capsaicin	13-22	KRAS proto-oncogene, GTPase	Homo sapiens	91-96
25944998-10	2015	The effect of SGD on pain pressure threshold in these rats was abolished by activators of TRPV1 (capsaicin), TRPV4 (RN1747), TRPA1 (Polygodial) and PAR2 (AC55541).	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	90-95
25896608-5	2015	The inhibitory effects of capsaicin were calcium-dependent, and mediated by the capsaicin receptor (transient receptor potential vanilloid type-1).	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	80-145
25407627-4	2015	c-Fos expression and the phosphorylation of ERK were induced by the intraoral application of capsaicin and by electrical stimulation of the inferior alveolar nerve (IAN), respectively.	Capsaicin	93-102	mitogen-activated protein kinase 1	Homo sapiens	44-47
25407627-5	2015	The number of c-Fos-IR neurons in the MDH induced by the intraoral application of capsaicin was increased after IAN injury, whereas the number of p-ERK immunoreactive neurons remained unchanged.	Capsaicin	82-91	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
25790456-4	2015	Here, using the keratin 5 promoter to selectively express the capsaicin receptor TRPV1 in keratinocytes of TRPV1-knockout mice, we achieved specific stimulation of keratinocytes with capsaicin.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	81-86
25220876-0	2015	Capsaicin-mediated apoptosis of human bladder cancer cells activates dendritic cells via CD91.	Capsaicin	0-9	LDL receptor related protein 1	Homo sapiens	89-93
25220876-3	2015	The aim of this study was to explore the effect of capsaicin-mediated cell death of bladder cancer cells on the activation of human monocyte-derived CD1a+ immature DCs.	Capsaicin	51-60	CD1a molecule	Homo sapiens	149-153
25220876-4	2015	METHODS: Immature DCs (generated from human peripheral blood-derived CD14+ monocytes cultured with granulocyte-macrophage colony stimulating factor and interleukin-4) were cocultured with capsaicin (CPS)-induced apoptotic bladder cancer cells.	Capsaicin	188-197	colony stimulating factor 2	Homo sapiens	99-147
25220876-4	2015	METHODS: Immature DCs (generated from human peripheral blood-derived CD14+ monocytes cultured with granulocyte-macrophage colony stimulating factor and interleukin-4) were cocultured with capsaicin (CPS)-induced apoptotic bladder cancer cells.	Capsaicin	199-202	colony stimulating factor 2	Homo sapiens	99-147
25220876-7	2015	RESULTS: We found that capsaicin-mediated cancer cell apoptosis upregulates CD86 and CD83 expression on DCs, indicating the induction of DC activation.	Capsaicin	23-32	CD86 molecule	Homo sapiens	76-80
25220876-7	2015	RESULTS: We found that capsaicin-mediated cancer cell apoptosis upregulates CD86 and CD83 expression on DCs, indicating the induction of DC activation.	Capsaicin	23-32	CD83 molecule	Homo sapiens	85-89
25220876-9	2015	CONCLUSIONS: Our data show that CPS-mediated cancer cell apoptosis activates DCs via CD91, suggesting CPS as an attractive candidate for cancer therapy.	Capsaicin	32-35	LDL receptor related protein 1	Homo sapiens	85-89
25220876-9	2015	CONCLUSIONS: Our data show that CPS-mediated cancer cell apoptosis activates DCs via CD91, suggesting CPS as an attractive candidate for cancer therapy.	Capsaicin	102-105	LDL receptor related protein 1	Homo sapiens	85-89
26130469-6	2015	Therapeutic effectiveness for this condition has been demonstrated through desensitization of TRPV1 channels with typical agonists such as capsaicin.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-99
25790456-4	2015	Here, using the keratin 5 promoter to selectively express the capsaicin receptor TRPV1 in keratinocytes of TRPV1-knockout mice, we achieved specific stimulation of keratinocytes with capsaicin.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	107-112
25774496-4	2015	The role of endogenous prostaglandins (PGs) and sensory afferent nerves releasing calcitonin gene-related peptide (CGRP) in the mechanism of gastroprotection induced by H2S was examined in capsaicin-denervated rats and those pretreated with capsazepine to inhibit activity of vanilloid receptors (VR-1).	Capsaicin	189-198	calcitonin-related polypeptide alpha	Rattus norvegicus	115-119
25781982-4	2015	In addition to ASICs, capsaicin- and heat-activated transient receptor potential vanilloid 1 (TRPV1) channels can also mediate proton-mediated pain signaling.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-92
25781982-4	2015	In addition to ASICs, capsaicin- and heat-activated transient receptor potential vanilloid 1 (TRPV1) channels can also mediate proton-mediated pain signaling.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-99
25774496-12	2015	These effects of NaHS on COX-1 and COX-2 protein contents were reversed by PAG and capsaicin denervation.	Capsaicin	83-92	mitochondrially encoded cytochrome c oxidase I	Homo sapiens	25-30
25774496-12	2015	These effects of NaHS on COX-1 and COX-2 protein contents were reversed by PAG and capsaicin denervation.	Capsaicin	83-92	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	35-40
25540101-6	2015	The Oxt-induced feeding suppression and c-Fos expression in nucleus tractus solitarius were blunted in mice whose vagal afferent nerves were blocked by subdiaphragmatic vagotomy or capsaicin treatment.	Capsaicin	181-190	oxytocin	Mus musculus	4-7
25445434-1	2015	The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed mainly by sensory neurons that detect noxious stimuli from the environment such as high temperatures and pungent compounds (such as allicin and capsaicin) and has been extensively linked to painful and inflammatory processes.	Capsaicin	222-231	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-44
25445434-1	2015	The Transient Receptor Potential Vanilloid 1 (TRPV1) ion channel is expressed mainly by sensory neurons that detect noxious stimuli from the environment such as high temperatures and pungent compounds (such as allicin and capsaicin) and has been extensively linked to painful and inflammatory processes.	Capsaicin	222-231	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
25540101-6	2015	The Oxt-induced feeding suppression and c-Fos expression in nucleus tractus solitarius were blunted in mice whose vagal afferent nerves were blocked by subdiaphragmatic vagotomy or capsaicin treatment.	Capsaicin	181-190	FBJ osteosarcoma oncogene	Mus musculus	40-45
25666822-0	2015	Discovery of non-electrophilic capsaicinoid-type TRPA1 ligands.	Capsaicin	31-43	transient receptor potential cation channel subfamily A member 1	Homo sapiens	49-54
25666693-1	2015	INTRODUCTION: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that can be activated by noxious heat, low pH and vanilloid compounds such as capsaicin.	Capsaicin	179-188	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-59
25666822-1	2015	Replacement of the benzylamide motif of synthetic capsaicin (nonivamide, 1c) with a tetrazole moiety was detrimental for TRPV1 binding, but unexpectedly generated a potent and non-electrophilic TRPA1 agonist (4a).	Capsaicin	50-59	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-126
25666822-1	2015	Replacement of the benzylamide motif of synthetic capsaicin (nonivamide, 1c) with a tetrazole moiety was detrimental for TRPV1 binding, but unexpectedly generated a potent and non-electrophilic TRPA1 agonist (4a).	Capsaicin	50-59	transient receptor potential cation channel subfamily A member 1	Homo sapiens	194-199
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	117-122
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-45	transient receptor potential cation channel subfamily A member 1	Homo sapiens	127-132
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	203-208
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-45	transient receptor potential cation channel subfamily A member 1	Homo sapiens	209-214
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	117-122
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-42	transient receptor potential cation channel subfamily A member 1	Homo sapiens	127-132
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-42	transient receptor potential cation channel subfamily V member 1	Homo sapiens	203-208
25666822-4	2015	These observations show that the capsaicinoid pharmacophore displays orthogonal structure-activity relationships for TRPV1 and TRPA1 binding, and suggest the possibility of obtaining compounds with dual TRPV1/TRPA1 modulatory properties by exploration of the chemical space around the capsaicin motif.	Capsaicin	33-42	transient receptor potential cation channel subfamily A member 1	Homo sapiens	209-214
25431172-4	2015	Depolarization of DRG neurons by a transient receptor potential vanilloid 1 (TRPV 1) activator, capsaicin was attenuated by E6005 as well as by a 3",5"-cyclic adenosine monophosphate (cAMP) elevator, forskolin.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-75
25431172-4	2015	Depolarization of DRG neurons by a transient receptor potential vanilloid 1 (TRPV 1) activator, capsaicin was attenuated by E6005 as well as by a 3",5"-cyclic adenosine monophosphate (cAMP) elevator, forskolin.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-83
25527778-6	2015	Hypothalamic TNF-alpha increased in capsaicin-treated mice, whereas intracerebroventricular infusion of the TNF-alpha blocker etanercept prevented capsaicin-induced upregulation of alpha-ENaCs.	Capsaicin	36-45	tumor necrosis factor	Mus musculus	13-22
25527778-6	2015	Hypothalamic TNF-alpha increased in capsaicin-treated mice, whereas intracerebroventricular infusion of the TNF-alpha blocker etanercept prevented capsaicin-induced upregulation of alpha-ENaCs.	Capsaicin	147-156	tumor necrosis factor	Mus musculus	108-117
25666693-1	2015	INTRODUCTION: Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel that can be activated by noxious heat, low pH and vanilloid compounds such as capsaicin.	Capsaicin	179-188	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
25666878-5	2015	The neutrophils in TRPM2 and TRPV1 experiments were stimulated by N-formyl-L-methionyl-L-leucyl-L-phenylalanine (fMLP; 1 muM) and capsaicin (10 muM) as concentration agonists, respectively.	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
25743118-5	2015	TRPV1 antagonists, capsazepine and SB-366791, attenuated capsaicin-induced nociceptive reaction in a concentration-dependent manner.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
25814480-1	2015	The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin.	Capsaicin	167-176	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-49
25814480-1	2015	The transient receptor potential vanilloid type 1 (TRPV1) channel, a ligand-gated cation channel of the TRP subfamily, can be activated by multiple stimuli, including capsaicin.	Capsaicin	167-176	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
27493509-3	2015	To understand the electrophysiological properties of the TRPV1-expressing muscle afferent neurons, we used whole-cell patch clamp recording to study the acid responsiveness and action potential (AP) configuration of capsaicin-sensitive neurons innervating to gastrocnemius muscle.	Capsaicin	216-225	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	57-62
25637531-9	2015	The TRPV1 agonist capsaicin significantly promoted migration, while a selective TRPV1 antagonist inhibited it.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-9
25603234-6	2015	The anti-oxidative activity of capsaicin was defined by Apo B fragmentation and conjugated diene production of the copper-mediated oxidation of LDL.	Capsaicin	31-40	apolipoprotein B	Mus musculus	56-61
25603234-7	2015	Capsaicin repressed ROS generation, as well as subsequent mitochondrial membrane potential collapse, cytochrome c expression, chromosome condensation, and caspase-3 activation induced by oxLDL in HUVECs.	Capsaicin	0-9	caspase 3	Mus musculus	155-164
25849380-0	2015	Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2+ influx.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
25849380-0	2015	Activation of TRPV1 channel by dietary capsaicin improves visceral fat remodeling through connexin43-mediated Ca2+ influx.	Capsaicin	39-48	gap junction protein, alpha 1	Mus musculus	90-100
25849380-8	2015	TRPV1 activation by capsaicin increased the influx of Ca2+ in 3T3-L1 preadipocytes and promoted cell lipolysis, as shown by Oil-red O staining.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
25568328-9	2015	Whereas none of the mutations selectively altered capsaicin-induced changes in NMDG permeability, the loss-of-function phenotypes seen with RTX stimulation of G618W and M644I were recapitulated in the capsaicin-evoked YO-PRO1 uptake assay.	Capsaicin	201-210	lamin A/C	Homo sapiens	221-225
25568328-10	2015	Curiously, the M644A substitution resulted in a loss, rather than a gain, in capsaicin-evoked YO-PRO1 uptake.	Capsaicin	77-86	lamin A/C	Homo sapiens	97-101
25745388-0	2015	Identifying the integrated neural networks involved in capsaicin-induced pain using fMRI in awake TRPV1 knockout and wild-type rats.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
25745388-4	2015	Capsaicin is an exogenous ligand for the TRPV1 receptor, and in wild-type rats, activated the putative pain neural circuit.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	41-46
25597011-2	2015	Among them, compound 15 showed highly potent TRPV1 antagonism to capsaicin, with Ki(ant)=0.2nM, as well as antagonism to other activators, and it was efficacious in a pain model.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-50
25849380-11	2015	Capsaicin increased the expression levels of p-CaM, Cx43, CaMKII, PPARdelta and HSL in mesenteric adipose tissues from WT mice fed a high-fat diet, db/db mice, as well as obese humans, but these effects of capsaicin were absent in TRPV1-/- mice.	Capsaicin	0-9	gap junction protein, alpha 1	Mus musculus	52-56
25590988-9	2015	Capsaicin potentially acts on both primary and secondary hyperalgesia in a TRPV1-dependent manner.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	75-80
25849380-11	2015	Capsaicin increased the expression levels of p-CaM, Cx43, CaMKII, PPARdelta and HSL in mesenteric adipose tissues from WT mice fed a high-fat diet, db/db mice, as well as obese humans, but these effects of capsaicin were absent in TRPV1-/- mice.	Capsaicin	0-9	calcium/calmodulin-dependent protein kinase II, delta	Mus musculus	58-64
25849380-11	2015	Capsaicin increased the expression levels of p-CaM, Cx43, CaMKII, PPARdelta and HSL in mesenteric adipose tissues from WT mice fed a high-fat diet, db/db mice, as well as obese humans, but these effects of capsaicin were absent in TRPV1-/- mice.	Capsaicin	0-9	peroxisome proliferator activator receptor delta	Mus musculus	66-75
25849380-11	2015	Capsaicin increased the expression levels of p-CaM, Cx43, CaMKII, PPARdelta and HSL in mesenteric adipose tissues from WT mice fed a high-fat diet, db/db mice, as well as obese humans, but these effects of capsaicin were absent in TRPV1-/- mice.	Capsaicin	0-9	lipase, hormone sensitive	Mus musculus	80-83
25849380-11	2015	Capsaicin increased the expression levels of p-CaM, Cx43, CaMKII, PPARdelta and HSL in mesenteric adipose tissues from WT mice fed a high-fat diet, db/db mice, as well as obese humans, but these effects of capsaicin were absent in TRPV1-/- mice.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	231-236
25849380-13	2015	CONCLUSION: This study demonstrated that capsaicin activation of TRPV1-evoked increased Ca2+ influx in Cx43-mediated adipocyte-to-adipocyte communication promotes lipolysis in both vitro and vivo.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
25849380-13	2015	CONCLUSION: This study demonstrated that capsaicin activation of TRPV1-evoked increased Ca2+ influx in Cx43-mediated adipocyte-to-adipocyte communication promotes lipolysis in both vitro and vivo.	Capsaicin	41-50	gap junction protein, alpha 1	Mus musculus	103-107
25849380-14	2015	TRPV1 activation by dietary capsaicin improves visceral fat remodeling through the up-regulation of Cx43.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
25849380-14	2015	TRPV1 activation by dietary capsaicin improves visceral fat remodeling through the up-regulation of Cx43.	Capsaicin	28-37	gap junction protein, alpha 1	Mus musculus	100-104
25713512-3	2015	Our results showed that systemic administration of TRPV1 agonist capsaicin (CAP, 40 mg/kg) directly induced tonic-clonic seizures (TCS) without PTZ induction.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	51-56
25713512-3	2015	Our results showed that systemic administration of TRPV1 agonist capsaicin (CAP, 40 mg/kg) directly induced tonic-clonic seizures (TCS) without PTZ induction.	Capsaicin	76-79	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	51-56
25069877-6	2015	RESULTS: The TRPV1 agonist capsaicin relaxed mouse mesenteric arteries with an EC50 of 25 nm, but large mouse renal arteries or rat descending vasa recta only at &gt;100-fold higher concentrations.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	13-18
25670201-3	2015	This regulation could contribute to the cellular mechanisms by which the TRPV1 activator capsaicin mitigates mechanical hypersensitivity.	Capsaicin	89-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
25670203-1	2015	Capsaicin is an activator of the heat-sensitive TRPV1 (transient receptor potential vanilloid 1) ion channels and has been used as a local analgesic.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
25670203-1	2015	Capsaicin is an activator of the heat-sensitive TRPV1 (transient receptor potential vanilloid 1) ion channels and has been used as a local analgesic.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-95
25670203-2	2015	We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the mechanosensitive Piezo1 and Piezo2 channels by depleting phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and its precursor phosphatidylinositol 4-phosphate [PI(4)P] from the plasma membrane through Ca(2+)-induced phospholipase Cdelta (PLCdelta) activation.	Capsaicin	48-57	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-33
25670203-2	2015	We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the mechanosensitive Piezo1 and Piezo2 channels by depleting phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and its precursor phosphatidylinositol 4-phosphate [PI(4)P] from the plasma membrane through Ca(2+)-induced phospholipase Cdelta (PLCdelta) activation.	Capsaicin	48-57	piezo type mechanosensitive ion channel component 1	Homo sapiens	167-173
25670203-2	2015	We found that activation of TRPV1 channels with capsaicin either in dorsal root ganglion neurons or in a heterologous expression system inhibited the mechanosensitive Piezo1 and Piezo2 channels by depleting phosphatidylinositol 4,5-bisphosphate [PI(4,5)P2] and its precursor phosphatidylinositol 4-phosphate [PI(4)P] from the plasma membrane through Ca(2+)-induced phospholipase Cdelta (PLCdelta) activation.	Capsaicin	48-57	piezo type mechanosensitive ion channel component 2	Homo sapiens	178-184
25670203-7	2015	In addition to revealing a role for distinct membrane lipids in mechanosensitive ion channel regulation, these data suggest that inhibition of Piezo2 channels may contribute to the analgesic effect of capsaicin.	Capsaicin	201-210	piezo type mechanosensitive ion channel component 2	Homo sapiens	143-149
25650413-7	2015	Voriconazole almost completely blocked capsaicin-activated currents in ON-bipolar cells, which have been attributed to direct activation of the TRPM1 cation channel.	Capsaicin	39-48	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	144-149
25069877-7	2015	The vasodilatory effect of capsaicin in the low-nanomolar concentration range was endothelium-dependent and absent in vessels of Trpv1 -/- mice.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	129-134
25069877-11	2015	The capsaicin effects were largely reduced in Trpv1 -/- kidneys, and the effects of GSK1016790A were inhibited in Trpv4 -/- kidneys.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
25381485-2	2015	Results of recent reports indicated that EMR can increase temperature and oxidative stress of body cells, and TRPV1 channel is activated by noxious heat, oxidative stress, and capsaicin (CAP).	Capsaicin	176-185	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	110-115
25387247-6	2015	TRPV1 desensitization by chronic capsaicin reduced the initial peak and slope.	Capsaicin	33-42	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
25460045-6	2015	TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response.	Capsaicin	65-74	transient receptor potential cation channel subfamily M member 8	Homo sapiens	0-5
25460045-6	2015	TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	138-153
25460045-6	2015	TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response.	Capsaicin	65-74	transient receptor potential cation channel subfamily V member 1	Homo sapiens	155-160
25460045-6	2015	TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response.	Capsaicin	76-79	transient receptor potential cation channel subfamily M member 8	Homo sapiens	0-5
25460045-6	2015	TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response.	Capsaicin	76-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	138-153
25460045-6	2015	TRPM8 activation by both 1microM T1AM and 20muM icilin prevented capsaicin (CAP) (20muM) from inducing increases in Ca(2+) influx through TRP vanilloid 1 (TRPV1) activation, whereas BCTC did not block this response.	Capsaicin	76-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	155-160
25184514-0	2015	Progesterone receptor chaperone complex-based high-throughput screening assay: identification of capsaicin as an inhibitor of the Hsp90 machine.	Capsaicin	97-106	progesterone receptor	Homo sapiens	0-21
25184514-0	2015	Progesterone receptor chaperone complex-based high-throughput screening assay: identification of capsaicin as an inhibitor of the Hsp90 machine.	Capsaicin	97-106	heat shock protein 90 alpha family class A member 1	Homo sapiens	130-135
25184514-8	2015	Cell survival assays showed that capsaicin selectively kills cancer cells and destabilizes several Hsp90 client proteins.	Capsaicin	33-42	heat shock protein 90 alpha family class A member 1	Homo sapiens	99-104
25250537-7	2015	PAO modulation of the capsaicin-activated current in hTRPV1/Chinese hamster ovary cells consisted of potentiation of the current elicited with low capsaicin concentrations and inhibition of the current at higher concentrations.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-59
25813723-5	2015	Capsaicin-induced decrease in metabolic activity and cell proliferation, and changes in the cell cycle were limited to high concentrations used (&gt;= 100 muM), whereas, at lower concentrations, capsaicin stimulated both DNA double strand breaks and micronuclei production.	Capsaicin	0-9	latexin	Homo sapiens	155-158
25813723-8	2015	A different magnitude of p53 binding protein 1 (53BP1) recruitment contributed to diverse capsaicin-induced genotoxic effects in DU145 and A549 cells.	Capsaicin	90-99	tumor protein p53 binding protein 1	Homo sapiens	25-46
25813723-8	2015	A different magnitude of p53 binding protein 1 (53BP1) recruitment contributed to diverse capsaicin-induced genotoxic effects in DU145 and A549 cells.	Capsaicin	90-99	tumor protein p53 binding protein 1	Homo sapiens	48-53
26434906-7	2015	However, silencing of p53 significantly abrogated apoptosis induced by capsaicin but not that by eugenol.	Capsaicin	71-80	tumor protein p53	Homo sapiens	22-25
25305668-6	2015	The neurons in TRPM2 and TRPV1 experiments were stimulated by hydrogen peroxide and capsaicin, respectively.	Capsaicin	84-93	transient receptor potential cation channel, subfamily M, member 2	Mus musculus	15-20
25305668-6	2015	The neurons in TRPM2 and TRPV1 experiments were stimulated by hydrogen peroxide and capsaicin, respectively.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-30
25307418-8	2015	RESULTS: Capsaicin reduced colony formation rates and radio-sensitized human PCa cells (Sensitizer enhancement ratio = 1.3) which corresponded to the suppression of NFkappaB, independent of TRP-V1 receptor.	Capsaicin	9-18	nuclear factor kappa B subunit 1	Homo sapiens	165-173
25307418-12	2015	DISCUSSION: Our findings suggest that capsaicin acts as a radio-sensitzing agent for PCa through the inhibition of NFkappaB signalling.	Capsaicin	38-47	nuclear factor kappa B subunit 1	Homo sapiens	115-123
25322817-5	2015	While sustaining mitochondrial transport did not reduce axonal swellings in capsaicin-treated axons, preventing mitochondrial fission by overexpression of mutant dynamin-related protein 1 increased mitochondrial length, retained mitochondrial membrane potentials and reduced axonal loss upon capsaicin treatment.	Capsaicin	292-301	dynamin 1 like	Homo sapiens	162-187
26602570-8	2015	Capsaicin and its analog capsinoids, representative agonists of TRPV1, mimic the effects of cold to decrease body fatness through the activation and recruitment of BAT.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	64-69
25355002-1	2015	Capsaicin was preparatively separated and purified from capsicum oleoresin with a new method combined with aqueous two-phase extraction (ATPE) and chromatography.	Capsaicin	0-9	ATP synthase F1 subunit epsilon	Homo sapiens	137-141
25355002-2	2015	Screening experiments of ATPE systems containing salts and hydrophilic alcohols showed that potassium carbonate/ethanol system was the most suitable system for capsaicin recovery among the systems considered.	Capsaicin	160-169	ATP synthase F1 subunit epsilon	Homo sapiens	25-29
26434906-3	2015	The aim of the study was to elucidate the role of p53 in the induction of apoptosis by eugenol and capsaicin in a human gastric cancer cell line, AGS.	Capsaicin	99-108	tumor protein p53	Homo sapiens	50-53
26434906-6	2015	RESULTS: In the presence of p53, capsaicin was a more potent pro-apoptotic agent than eugenol.	Capsaicin	33-42	tumor protein p53	Homo sapiens	28-31
24867493-0	2015	Distribution of glutathione peroxidase 1 in liver tissues of healthy and diabetic rats treated with capsaisin.	Capsaicin	100-109	glutathione peroxidase 1	Rattus norvegicus	16-40
24867493-8	2015	In all groups, GPx 1 showed similar immunolocalization, but in the diabetic and diabetic + CAP groups, GPx 1 immunoreactivity was less than in the other groups.	Capsaicin	91-94	glutathione peroxidase 1	Rattus norvegicus	103-108
26411767-8	2015	Thus activation of TRPV1 by oxidative stress, resiniferatoxin, cannabinoid receptor (CB1) activators (i.e. anandamide) or capsaicin induced epileptic effects, and these effects could be reduced by appropriate inhibitors, including capsazepine (CPZ), 5"-iodoresiniferatoxin (IRTX), resolvins, and CB1 antagonists.	Capsaicin	122-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-24
25479918-10	2015	Although the TRPV1 agonist, capsaicin (100 nM) evoked no response at room temperature, it triggered cationic currents and [Ca(2+)]i elevation when the temperature was increased to 36 C. These results suggest that AVP neurones in the rat SON possess functional full-length TRPV1.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
25479918-10	2015	Although the TRPV1 agonist, capsaicin (100 nM) evoked no response at room temperature, it triggered cationic currents and [Ca(2+)]i elevation when the temperature was increased to 36 C. These results suggest that AVP neurones in the rat SON possess functional full-length TRPV1.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	272-277
26411767-8	2015	Thus activation of TRPV1 by oxidative stress, resiniferatoxin, cannabinoid receptor (CB1) activators (i.e. anandamide) or capsaicin induced epileptic effects, and these effects could be reduced by appropriate inhibitors, including capsazepine (CPZ), 5"-iodoresiniferatoxin (IRTX), resolvins, and CB1 antagonists.	Capsaicin	122-131	cannabinoid receptor 1	Homo sapiens	296-299
25959004-1	2015	Capsaicin, a pharmacologically active agent found in chili peppers, causes burning and itching sensation due to binding at the transient receptor potential vanilloid-1 (TRPV-1) receptor, a polymodal receptor critical to the sensing of a variety of stimuli (e.g., noxious heat, bidirectional pH), and subsequent activation of polymodal C and A-delta nociceptive fibers.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	169-175
26004410-7	2015	The increase in the GMBF response associated with acid back-diffusion after the TC treatment was also inhibited by the chemical ablation of capsaicin-sensitive afferent neurons, but not capsazepine, a TRPV1 antagonist.	Capsaicin	140-149	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	201-206
26004410-8	2015	Thus, endogenous PGE2 produced by COX-1 plays a role in the gastric hyperemic response following barrier disruption of the stomach by interacting with capsaicin-sensitive afferent neurons, mainly through EP1 receptors, and facilitating the GMBF response to acid back-diffusion.	Capsaicin	151-160	cytochrome c oxidase I, mitochondrial	Mus musculus	34-39
25678312-0	2015	Effects of capsicine on rat cytochrome P450 isoforms CYP1A2, CYP2C19, and CYP3A4.	Capsaicin	11-20	cytochrome P450, family 1, subfamily a, polypeptide 2	Rattus norvegicus	53-59
25959004-4	2015	Local application of high concentration of capsaicin is used for neuropathic pain and repeated stimulation of TRPV-1 induced an improvement of epigastric pain in irritable bowel syndrome and dyspepsia patients by desensitization of nociceptive pathways.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-116
25422952-0	2015	Capsaicin, nonivamide and trans-pellitorine decrease free fatty acid uptake without TRPV1 activation and increase acetyl-coenzyme A synthetase activity in Caco-2 cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	84-89
25422952-3	2015	Capsaicin and nonivamide were found to reduce fatty acid uptake, with IC50 values of 0.49 muM and 1.08 muM, respectively.	Capsaicin	0-9	latexin	Homo sapiens	90-93
25422952-3	2015	Capsaicin and nonivamide were found to reduce fatty acid uptake, with IC50 values of 0.49 muM and 1.08 muM, respectively.	Capsaicin	0-9	latexin	Homo sapiens	103-106
25422952-6	2015	However, acetyl-coenzyme A synthetase activity increased (p&lt;0.05) in the presence of 10 muM capsaicin, nonivamide or trans-pellitorine, pointing to an increased fatty acid biosynthesis that might counteract the decreased fatty acid uptake.	Capsaicin	95-104	latexin	Homo sapiens	91-94
25959004-2	2015	Acutely, TRPV-1 activation with peripheral capsaicin produces pronociceptive effects, which extends to the development of hyperalgesia and allodynia.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-15
25959004-3	2015	However, capsaicin has been reported to display antinociceptive properties as well, largely through TRPV-1-dependent mechanisms.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-106
25997958-0	2015	Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways.	Capsaicin	26-35	mitogen-activated protein kinase 8	Homo sapiens	134-137
24557717-7	2015	The method was applied to qualify capsaicinoid content of two industrial capsicum extracts according to the USP 29.	Capsaicin	34-46	ubiquitin specific peptidase 29	Homo sapiens	108-114
26109436-1	2015	BACKGROUND: The capsaicin and heat responsive ion channel TRPV1 is expressed on trigeminal nociceptive neurons and has been implicated in the pathophysiology of migraine attacks.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-63
26109436-5	2015	In a second model, CGRP release into the external jugular vein was determined following injection of capsaicin into the carotid artery.	Capsaicin	101-110	calcitonin-related polypeptide alpha	Rattus norvegicus	19-23
26109436-7	2015	Capsaicin-induced CGRP release was attenuated by JNJ-38893777 only in higher dosage.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	18-22
26617436-5	2015	Here, by performing TMJ injection of a retrograde labeling tracer DiI (a fluorescent dye), I showed that maresin 1 potently inhibits capsaicin-induced TRPV1 currents and neuronal activity via Galphai-coupled G-protein coupled receptors in DiI-labeled trigeminal nociceptive neurons.	Capsaicin	133-142	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	151-156
25997958-0	2015	Induction of apoptosis by capsaicin in hepatocellular cancer cell line SMMC-7721 is mediated through ROS generation and activation of JNK and p38 MAPK pathways.	Capsaicin	26-35	mitogen-activated protein kinase 14	Homo sapiens	142-145
25997958-5	2015	We also found that capsaicin induced JNK and p38 MAPK phosphorylation.	Capsaicin	19-28	mitogen-activated protein kinase 8	Homo sapiens	37-40
25997958-5	2015	We also found that capsaicin induced JNK and p38 MAPK phosphorylation.	Capsaicin	19-28	mitogen-activated protein kinase 14	Homo sapiens	45-48
25997958-6	2015	JNK and p38 MAPK inhibitor effectively blocked capsaicin-induced SMMC-7721 cell apoptosis.	Capsaicin	47-56	mitogen-activated protein kinase 8	Homo sapiens	0-3
25997958-6	2015	JNK and p38 MAPK inhibitor effectively blocked capsaicin-induced SMMC-7721 cell apoptosis.	Capsaicin	47-56	mitogen-activated protein kinase 14	Homo sapiens	8-11
25997958-7	2015	In addition, NAC completely blocked phosphorylation of JNK and p38 MAPK induced by capsaicin.	Capsaicin	83-92	mitogen-activated protein kinase 8	Homo sapiens	55-58
25997958-7	2015	In addition, NAC completely blocked phosphorylation of JNK and p38 MAPK induced by capsaicin.	Capsaicin	83-92	mitogen-activated protein kinase 14	Homo sapiens	63-66
25997958-8	2015	Our results indicate that capsaicin induced in SMMC-7721 cell apoptosis through generation of intracellular ROS and activation of JNK and p38 MAPK pathways.	Capsaicin	26-35	mitogen-activated protein kinase 8	Homo sapiens	130-133
25997958-8	2015	Our results indicate that capsaicin induced in SMMC-7721 cell apoptosis through generation of intracellular ROS and activation of JNK and p38 MAPK pathways.	Capsaicin	26-35	mitogen-activated protein kinase 14	Homo sapiens	138-141
25079903-3	2015	The open pore of capsaicin-activated TRPV1 channel admits organic molecules such as local anesthetics and we calculated that GBP entry via this route would be 500x more rapid than via the transporter.	Capsaicin	17-26	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-42
25079903-6	2015	Under these conditions, capsaicin produced a capsazepine-sensitive inward current thereby confirming Q-GBP permeation of TRPV1 channels.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	121-126
25079903-11	2015	Capsaicin potentiation of GBP depression of dorsal horn activity may therefore reflect drug permeation of TRPV1 channels.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	106-111
24858305-0	2014	Dietary capsaicin ameliorates pressure overload-induced cardiac hypertrophy and fibrosis through the transient receptor potential vanilloid type 1.	Capsaicin	8-17	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	101-146
25242356-5	2014	FKI inhibited TRPV1 mediated capsaicin-induced ERK phosphorylation and reduced tumor-induced proinflammatory cytokine production.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
25277470-1	2015	OBJECTIVE: Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Adelta fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	115-155
25277470-1	2015	OBJECTIVE: Epicutaneous application of capsaicin causes a long-lasting analgesic effect by binding to the membrane transient receptor potential vanilloid 1 (TRPV1) on mechanoheat-sensitive C and Adelta fibres, changing axonal integrity and inhibiting neurogenic inflammatory processes.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	157-162
25231620-8	2014	Finally, all neurons from both groups exhibited an inward current following exposure of the transient potential receptor vanilloid 1 (TRPV1) agonist, 8-methyl-N-vanillyl-6-nonenamide.	Capsaicin	150-182	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	92-132
25231620-8	2014	Finally, all neurons from both groups exhibited an inward current following exposure of the transient potential receptor vanilloid 1 (TRPV1) agonist, 8-methyl-N-vanillyl-6-nonenamide.	Capsaicin	150-182	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	134-139
25505315-4	2014	Here, using a combination of pharmacology, electrophysiology, and an in vivo knockdown strategy, we report that TRPV1 activation by capsaicin or by the endocannabinoid anandamide depresses somatic, but not dendritic inhibitory transmission in both rat and mouse dentate gyrus.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	112-117
25446918-6	2014	The suppression of nerve stimulus evoked acetylcholine release by CAP was antagonized by capsazepine (CPZ), a TRPV1 antagonist.	Capsaicin	66-69	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	110-115
24858305-1	2014	BACKGROUND: Dietary capsaicin plays a protective role in hypertension, atherosclerosis, obesity, and hyperlipidemia through activating the transient receptor potential vanilloid type 1 (TRPV1), a nonselective cation channel.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	139-184
24858305-1	2014	BACKGROUND: Dietary capsaicin plays a protective role in hypertension, atherosclerosis, obesity, and hyperlipidemia through activating the transient receptor potential vanilloid type 1 (TRPV1), a nonselective cation channel.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	186-191
24858305-6	2014	Additionally, capsaicin blunted pressure overload-induced upregulation of transforming growth factor beta, connective tissue growth factor, and the phosphorylation of Smad2/3 in WT mice but not in TRPV1 KO mice.	Capsaicin	14-23	SMAD family member 2	Mus musculus	167-174
24858305-7	2014	Moreover, capsaicin attenuated pressure overload-induced overexpression of metalloproteinase (MMP)-2, MMP-9 and MMP-13 in WT mice but not in TRPV1 KO mice.	Capsaicin	10-19	matrix metallopeptidase 2	Mus musculus	75-100
24858305-7	2014	Moreover, capsaicin attenuated pressure overload-induced overexpression of metalloproteinase (MMP)-2, MMP-9 and MMP-13 in WT mice but not in TRPV1 KO mice.	Capsaicin	10-19	matrix metallopeptidase 9	Mus musculus	102-107
24858305-7	2014	Moreover, capsaicin attenuated pressure overload-induced overexpression of metalloproteinase (MMP)-2, MMP-9 and MMP-13 in WT mice but not in TRPV1 KO mice.	Capsaicin	10-19	matrix metallopeptidase 13	Mus musculus	112-118
24858305-8	2014	Capsaicin also attenuated angiotensin II-induced proliferation of cardiac fibroblasts from mice with the TRPV1 channel.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	105-110
24858305-9	2014	CONCLUSIONS: Our results suggest that dietary capsaicin protects against cardiac hypertrophy and fibrosis in pressure overload mice through TRPV1.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	140-145
25217963-7	2014	In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation.	Capsaicin	149-158	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	53-57
25189505-4	2014	The number of c-Fos protein-like immunoreactive (Fos-LI) neurons in the medullary dorsal horn (MDH) induced by the intraoral application of capsaicin was measured.	Capsaicin	140-149	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-19
25189505-6	2014	RESULTS: Larger doses of intraoral capsaicin (1, 10 and 100mug) induced vigorous licking behaviour and c-Fos response in the MDH in a reproducible manner.	Capsaicin	35-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	103-108
25189505-7	2014	The magnitudes of both behavioural activity and the c-Fos response from the 10 and 100mug doses of capsaicin were significantly greater than that by the 1mug dose.	Capsaicin	99-108	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-57
25189505-8	2014	Injury to the IAN exaggerated the behavioural and c-Fos responses evoked by intraoral capsaicin.	Capsaicin	86-95	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	50-55
25117291-7	2014	Capsaicin (CGRP depletor), capsazepine and ruthenium red (TRPV1 inhibitors) attenuated the PNS-induced decrease in pH and vasodilatation.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	11-15
25358373-5	2014	Peroxisome proliferator-activated receptor gamma, cytosine-cytosine-adenosine-adenosine-thymidine/enhancer binding protein alpha, fatty acid binding protein 4, and stearoyl-CoA desaturase expression decreased after capsaicin treatment.	Capsaicin	215-224	peroxisome proliferator activated receptor gamma	Bos taurus	0-48
25358373-5	2014	Peroxisome proliferator-activated receptor gamma, cytosine-cytosine-adenosine-adenosine-thymidine/enhancer binding protein alpha, fatty acid binding protein 4, and stearoyl-CoA desaturase expression decreased after capsaicin treatment.	Capsaicin	215-224	stearoyl-CoA desaturase	Bos taurus	164-187
25358373-7	2014	Furthermore, we found that capsaicin increased the expression levels of apoptotic genes, such as B-cell lymphoma 2-associated X protein and caspase 3.	Capsaicin	27-36	caspase 3	Bos taurus	140-149
25217963-0	2014	Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-kappaB signaling pathway.	Capsaicin	0-9	matrix metallopeptidase 9	Homo sapiens	82-108
25217963-0	2014	Capsaicin suppresses the migration of cholangiocarcinoma cells by down-regulating matrix metalloproteinase-9 expression via the AMPK-NF-kappaB signaling pathway.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	128-132
25217963-6	2014	Capsaicin also inhibited the expression of matrix metalloproteinase-9 (MMP-9).	Capsaicin	0-9	matrix metallopeptidase 9	Homo sapiens	43-69
25217963-6	2014	Capsaicin also inhibited the expression of matrix metalloproteinase-9 (MMP-9).	Capsaicin	0-9	matrix metallopeptidase 9	Homo sapiens	71-76
25217963-7	2014	In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation.	Capsaicin	149-158	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	121-125
25217963-7	2014	In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation.	Capsaicin	3-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	53-57
25217963-7	2014	In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation.	Capsaicin	149-158	sirtuin 1	Homo sapiens	186-191
25217963-7	2014	In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation.	Capsaicin	3-12	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	121-125
25217963-7	2014	In capsaicin-treated cells, levels of phosphorylated AMPK increased, and this effect was abolished by treatment with the AMPK inhibitor, Compound C. Capsaicin enhanced the expression of SIRT1, which can activate the transcription factor NF-kappaB by deacetylation.	Capsaicin	3-12	sirtuin 1	Homo sapiens	186-191
25217963-8	2014	This suggests that NF-kappaB is activated by capsaicin via the SIRT1 pathway.	Capsaicin	45-54	sirtuin 1	Homo sapiens	63-68
25217963-9	2014	In addition, capsaicin-activated AMPK induced the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	33-37
25217963-9	2014	In addition, capsaicin-activated AMPK induced the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	NFKB inhibitor alpha	Homo sapiens	69-81
25217963-9	2014	In addition, capsaicin-activated AMPK induced the phosphorylation of IkappaBalpha and nuclear localization of NF-kappaB p65.	Capsaicin	13-22	RELA proto-oncogene, NF-kB subunit	Homo sapiens	120-123
25217963-10	2014	Chromatin immunoprecipitation assays demonstrated that capsaicin reduced MMP-9 transcription by inhibiting NF-kappaB p65 translocation and deacetylation via SIRT1.	Capsaicin	55-64	matrix metallopeptidase 9	Homo sapiens	73-78
25217963-10	2014	Chromatin immunoprecipitation assays demonstrated that capsaicin reduced MMP-9 transcription by inhibiting NF-kappaB p65 translocation and deacetylation via SIRT1.	Capsaicin	55-64	RELA proto-oncogene, NF-kB subunit	Homo sapiens	117-120
25217963-10	2014	Chromatin immunoprecipitation assays demonstrated that capsaicin reduced MMP-9 transcription by inhibiting NF-kappaB p65 translocation and deacetylation via SIRT1.	Capsaicin	55-64	sirtuin 1	Homo sapiens	157-162
25217963-11	2014	These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression.	Capsaicin	37-46	RELA proto-oncogene, NF-kB subunit	Homo sapiens	137-140
25217963-11	2014	These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression.	Capsaicin	37-46	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	149-153
25217963-11	2014	These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression.	Capsaicin	37-46	sirtuin 1	Homo sapiens	154-159
25217963-11	2014	These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression.	Capsaicin	37-46	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	168-172
25217963-11	2014	These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression.	Capsaicin	37-46	NFKB inhibitor alpha	Homo sapiens	173-185
25217963-11	2014	These findings provide evidence that capsaicin suppresses the migration and invasion of cholangiocarcinoma cells by inhibiting NF-kappaB p65 via the AMPK-SIRT1 and the AMPK-IkappaBalpha signaling pathways, leading to subsequent suppression of MMP-9 expression.	Capsaicin	37-46	matrix metallopeptidase 9	Homo sapiens	243-248
24643480-6	2014	A TRPV1::TRPA1 concatemer was responsive to TRPV1 agonists capsaicin, acidic pH and ethanol, but not to TRPA1 agonists.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	2-7
25450464-6	2014	Furthermore, the TRPV1 agonists capsaicin and anandamide decreased cytotrophoblast viability and induced morphological alterations, such as chromatin condensation and fragmentation, which suggest the occurrence of apoptosis.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
25450464-8	2014	Furthermore, capsaicin (10 muM) impaired the spontaneous in vitro differentiation of cytotrophoblasts into syncytiotrophoblasts by triggering TRPV1, as observed by the decrease in placental alkaline phosphatase activity and in human chorionic gonadotropin secretion.	Capsaicin	13-22	latexin	Homo sapiens	27-30
25450464-8	2014	Furthermore, capsaicin (10 muM) impaired the spontaneous in vitro differentiation of cytotrophoblasts into syncytiotrophoblasts by triggering TRPV1, as observed by the decrease in placental alkaline phosphatase activity and in human chorionic gonadotropin secretion.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	142-147
25371244-0	2014	TRPA1 contributes to capsaicin-induced facial cold hyperalgesia in rats.	Capsaicin	21-30	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	0-5
25371244-7	2014	The TG neuronal excitability to noxious cold stimulation was significantly increased following facial capsaicin injection and this increase was recovered by pretreatment with TRPA1 antagonist.	Capsaicin	102-111	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	175-180
25371244-8	2014	These findings suggest that TRPA1 sensitization via TRPV1 signaling in TG neurons is involved in cold hyperalgesia following facial skin capsaicin injection.	Capsaicin	137-146	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	28-33
25371244-8	2014	These findings suggest that TRPA1 sensitization via TRPV1 signaling in TG neurons is involved in cold hyperalgesia following facial skin capsaicin injection.	Capsaicin	137-146	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-57
25216685-4	2014	The vanilloid agonist resiniferatoxin dramatically reduces cathepsin K levels and osteoclast numbers in vitro, without affecting tartrate-resistant acid phosphatase expression.	Capsaicin	4-13	cathepsin K	Homo sapiens	59-70
24326980-2	2014	In an earlier study, we found that stimulation of pharyngeal sensory neurons by capsaicinoids acting on transient receptor potential vanilloid 1 (TRPV1) improved the swallow response of dysphagic patients.	Capsaicin	80-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	104-144
24326980-2	2014	In an earlier study, we found that stimulation of pharyngeal sensory neurons by capsaicinoids acting on transient receptor potential vanilloid 1 (TRPV1) improved the swallow response of dysphagic patients.	Capsaicin	80-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	146-151
25598668-5	2014	However, capsaicin (CAP), TRPV1 agonist, had little effect on intracellular free calcium concentration ([Ca(2+)]i) in these cells, although carbachol consistently increased [Ca(2+)]i.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	26-31
24643480-6	2014	A TRPV1::TRPA1 concatemer was responsive to TRPV1 agonists capsaicin, acidic pH and ethanol, but not to TRPA1 agonists.	Capsaicin	59-68	transient receptor potential cation channel subfamily A member 1	Homo sapiens	9-14
24643480-6	2014	A TRPV1::TRPA1 concatemer was responsive to TRPV1 agonists capsaicin, acidic pH and ethanol, but not to TRPA1 agonists.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-49
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	75-84	transient receptor potential cation channel subfamily A member 1	Homo sapiens	38-43
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	185-190
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	185-190
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	185-190
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	128-137	transient receptor potential cation channel subfamily A member 1	Homo sapiens	38-43
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	185-190
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	185-190
24643480-12	2014	However, the channel formed by TRPV1::TRPA1 has only two binding sites for capsaicin and shows less total current and a smaller capsaicin-induced shift in voltage-dependent gating than TRPV1::TRPV1 or TRPV1.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	185-190
25431213-0	2014	Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Galphai/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons.	Capsaicin	96-105	mitogen-activated protein kinase 14	Mus musculus	27-30
25431213-0	2014	Sphingosine 1-phosphate to p38 signaling via S1P1 receptor and Galphai/o evokes augmentation of capsaicin-induced ionic currents in mouse sensory neurons.	Capsaicin	96-105	sphingosine-1-phosphate receptor 1	Mus musculus	45-49
25431213-4	2014	In this study, the S1P mediated signaling pathway required for sensitization of TRPV1 channels was explored.The capsaicin induced peak inward current (ICAPS) of sensory neurons was significantly increased after S1P stimulation within minutes after application.	Capsaicin	112-121	sphingosine-1-phosphate receptor 1	Mus musculus	19-22
25431213-4	2014	In this study, the S1P mediated signaling pathway required for sensitization of TRPV1 channels was explored.The capsaicin induced peak inward current (ICAPS) of sensory neurons was significantly increased after S1P stimulation within minutes after application.	Capsaicin	112-121	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	80-85
25431213-4	2014	In this study, the S1P mediated signaling pathway required for sensitization of TRPV1 channels was explored.The capsaicin induced peak inward current (ICAPS) of sensory neurons was significantly increased after S1P stimulation within minutes after application.	Capsaicin	112-121	sphingosine-1-phosphate receptor 1	Mus musculus	211-214
28962318-5	2014	Treatment with LPS (20 mg/kg, ip) + Cap (4 mg/kg, sc)-treated group was significantly decreased both circulating sTNF levels (after 1 h only) and TNF-alpha mRNA expression (after 6 h) compared to the LPS-treated group.	Capsaicin	36-39	tumor necrosis factor	Mus musculus	146-155
25029033-7	2014	The prototypical TRPV1 agonist, capsaicin, produced similar, although not identical effects.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
25029033-8	2014	Capsaicin, but not CBDV, effects on burst amplitude were reversed by IRTX, a selective TRPV1 antagonist.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
25029033-10	2014	However, TRPV1 was strongly phosphorylated (and hence likely sensitized) in Mg(2+)-free solution-treated hippocampal tissue, and both capsaicin and CBDV caused TRPV1 dephosphorylation, consistent with TRPV1 desensitization.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-165
25029033-10	2014	However, TRPV1 was strongly phosphorylated (and hence likely sensitized) in Mg(2+)-free solution-treated hippocampal tissue, and both capsaicin and CBDV caused TRPV1 dephosphorylation, consistent with TRPV1 desensitization.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-165
25392504-3	2014	Recently, we demonstrated that knock-out or pharmacological inhibition of the TRP vanilloid-1 (TRPV1) capsaicin-sensitive subunit accelerates degeneration of retinal ganglion cell neurons and their axons with elevated ocular pressure, the critical stressor in the most common optic neuropathy, glaucoma.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-93
25392504-3	2014	Recently, we demonstrated that knock-out or pharmacological inhibition of the TRP vanilloid-1 (TRPV1) capsaicin-sensitive subunit accelerates degeneration of retinal ganglion cell neurons and their axons with elevated ocular pressure, the critical stressor in the most common optic neuropathy, glaucoma.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
24996127-4	2014	Our capsaicin stimulus evoked c-Fos expression in a select population of neurons within rostral trigeminal nucleus caudalis in anesthetized rats.	Capsaicin	4-13	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	30-35
25266715-2	2014	TRPV1 is activated by noxious heat (&gt; 43 C), acidic conditions (pH &lt; 6.6), capsaicin, and endovanilloids.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
25266715-7	2014	Capsaicin, a TRPV1 agonist, elevated intracellular Ca(2+) levels in the gingival epithelial cell line, epi 4.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	13-18
25266715-9	2014	These responses to capsaicin were inhibited by a specific TRPV1 antagonist, SB-366791.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	58-63
25266715-15	2014	Among them, fibroblast growth factor-17 and neuregulin 2 were significantly up-regulated in capsaicin-treated epi 4 cells.	Capsaicin	92-101	fibroblast growth factor 17	Mus musculus	12-39
25323897-1	2014	PURPOSE: Transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated nonselective cation channel, which can be activated by capsaicin and other noxious stimuli.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	9-49
25323897-1	2014	PURPOSE: Transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated nonselective cation channel, which can be activated by capsaicin and other noxious stimuli.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
25254316-5	2014	Using this approach, we pinpointed regions of TRPV1 that affect channel properties upon their removal, causing changes in current amplitude, single-channel conductance, and EC50 value toward its agonist, capsaicin.	Capsaicin	204-213	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
28962318-7	2014	Since Cap inhibits this initial increase as biomarkers, circulating sTNF, it is considered a potent treatment option for TNF-alpha-related diseases, such as septicemia.	Capsaicin	6-9	tumor necrosis factor	Mus musculus	121-130
25220703-2	2014	Previously, our lab has shown that a priming dose of ET-1 produces sensitization to capsaicin-induce secondary hyperalgesia.	Capsaicin	84-93	endothelin 1	Homo sapiens	53-57
25297108-6	2014	Functionally, endogenous GDNF released from peptidergic CGRP/somatostatin+ nociceptors upon capsaicin stimulation exert a tonic inhibitory control on the glutamate excitatory drive of SDH neurons as measured after ERK1/2 phosphorylation assay.	Capsaicin	92-101	glial cell line derived neurotrophic factor	Mus musculus	25-29
25330307-7	2014	Capsaicin ameliorated the outcome of AKI, as measured by serum creatinine levels, tubular damage,neutrophil gelatinase-associated lipocalin (NGAL) abundance and Ly-6B.2 positive polymorphonuclear inflammatory cells in injured kidneys.	Capsaicin	0-9	lipocalin 2	Mus musculus	97-139
25330307-7	2014	Capsaicin ameliorated the outcome of AKI, as measured by serum creatinine levels, tubular damage,neutrophil gelatinase-associated lipocalin (NGAL) abundance and Ly-6B.2 positive polymorphonuclear inflammatory cells in injured kidneys.	Capsaicin	0-9	lymphocyte antigen 6 complex, locus B	Mus musculus	161-166
25117406-0	2014	Role of capsaicin-sensitive peripheral sensory neurons in anorexic responses to intravenous infusions of cholecystokinin, peptide YY-(3-36), and glucagon-like peptide-1 in rats.	Capsaicin	8-17	cholecystokinin	Rattus norvegicus	105-120
25117406-0	2014	Role of capsaicin-sensitive peripheral sensory neurons in anorexic responses to intravenous infusions of cholecystokinin, peptide YY-(3-36), and glucagon-like peptide-1 in rats.	Capsaicin	8-17	glucagon	Rattus norvegicus	145-168
25117406-1	2014	Cholecystokinin (CCK)-induced suppression of feeding is mediated by vagal sensory neurons that are destroyed by the neurotoxin capsaicin (CAP).	Capsaicin	127-136	cholecystokinin	Rattus norvegicus	0-15
25117406-1	2014	Cholecystokinin (CCK)-induced suppression of feeding is mediated by vagal sensory neurons that are destroyed by the neurotoxin capsaicin (CAP).	Capsaicin	127-136	cholecystokinin	Rattus norvegicus	17-20
25117406-1	2014	Cholecystokinin (CCK)-induced suppression of feeding is mediated by vagal sensory neurons that are destroyed by the neurotoxin capsaicin (CAP).	Capsaicin	138-141	cholecystokinin	Rattus norvegicus	0-15
25117406-1	2014	Cholecystokinin (CCK)-induced suppression of feeding is mediated by vagal sensory neurons that are destroyed by the neurotoxin capsaicin (CAP).	Capsaicin	138-141	cholecystokinin	Rattus norvegicus	17-20
25117406-2	2014	Here we determined whether CAP-sensitive neurons mediate anorexic responses to intravenous infusions of gut hormones peptide YY-(3-36) [PYY-(3-36)] and glucagon-like peptide-1 (GLP-1).	Capsaicin	27-30	glucagon	Rattus norvegicus	152-175
25117406-2	2014	Here we determined whether CAP-sensitive neurons mediate anorexic responses to intravenous infusions of gut hormones peptide YY-(3-36) [PYY-(3-36)] and glucagon-like peptide-1 (GLP-1).	Capsaicin	27-30	glucagon	Rattus norvegicus	177-182
25299597-0	2014	Mass-spectrometric identification of T-kininogen I/thiostatin as an acute-phase inflammatory protein suppressed by curcumin and capsaicin.	Capsaicin	128-137	kininogen 2	Rattus norvegicus	37-50
25299597-0	2014	Mass-spectrometric identification of T-kininogen I/thiostatin as an acute-phase inflammatory protein suppressed by curcumin and capsaicin.	Capsaicin	128-137	kininogen 2	Rattus norvegicus	51-61
25299597-8	2014	The results demonstrate that curcumin and capsaicin lower the acute-phase inflammatory response, the molecular mechanism for which is, in part, mediated by pathways associated with the lowering of T-kininogen I.	Capsaicin	42-51	kininogen 2	Rattus norvegicus	197-210
25220703-8	2014	Similarly, ET-1 priming decreases capsaicin-induced [Ca(2+)]i transients.	Capsaicin	34-43	endothelin 1	Homo sapiens	11-15
25220703-9	2014	At the level of the primary afferent neuron, ET-1 priming has a desensitizing effect on challenge exposures to ET-1 and capsaicin.	Capsaicin	120-129	endothelin 1	Homo sapiens	45-49
25314299-6	2014	Although neuropeptide release caused by TRPV1 activation on sensory neurons elicits a cardioprotective effect, we found that capsaicin (CAP; a TRPV1 agonist) treatment of H9C2 cells paradoxically enhanced the level of apoptosis by increasing intracellular calcium and mitochondrial superoxide levels, attenuating mitochondrial membrane potential, and inhibiting mitochondrial biogenesis (measured by the expression of ATP synthase beta).	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	143-148
25314299-6	2014	Although neuropeptide release caused by TRPV1 activation on sensory neurons elicits a cardioprotective effect, we found that capsaicin (CAP; a TRPV1 agonist) treatment of H9C2 cells paradoxically enhanced the level of apoptosis by increasing intracellular calcium and mitochondrial superoxide levels, attenuating mitochondrial membrane potential, and inhibiting mitochondrial biogenesis (measured by the expression of ATP synthase beta).	Capsaicin	136-139	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	143-148
25297108-6	2014	Functionally, endogenous GDNF released from peptidergic CGRP/somatostatin+ nociceptors upon capsaicin stimulation exert a tonic inhibitory control on the glutamate excitatory drive of SDH neurons as measured after ERK1/2 phosphorylation assay.	Capsaicin	92-101	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	56-60
25297108-7	2014	Real-time Ca(2+) imaging and patch-clamp experiments with bath-applied GDNF (100 nM) confirm the presynaptic inhibition of SDH neurons after stimulation of capsaicin-sensitive, nociceptive primary afferent fibers.	Capsaicin	156-165	glial cell line derived neurotrophic factor	Mus musculus	71-75
25297108-8	2014	Accordingly, the reduction of the capsaicin-evoked [Ca(2+)]i rise and of the frequency of mEPSCs in SDH neurons is specifically abolished after enzymatic ablation of GFRalpha1.	Capsaicin	34-43	glial cell line derived neurotrophic factor family receptor alpha 1	Mus musculus	166-175
25289759-10	2014	Capsaicin reduced the mRNA levels of tissue inhibitors of metalloproteinase 1 (TIMP-1) and transforming growth factor-beta1 (TGF-beta1) in HSCs.	Capsaicin	0-9	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	37-77
24975423-0	2014	Effects of neonatal treatment with the TRPV1 agonist, capsaicin, on adult rat brain and behaviour.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	39-44
24975423-1	2014	Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	36-76
24975423-1	2014	Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-83
24975423-1	2014	Treatment of neonatal rats with the transient receptor potential vanilloid 1 (TRPV1) channel agonist, capsaicin, produces life-long loss of sensory neurons expressing TRPV1 channels.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	167-172
24975423-9	2014	In conclusion, several neuroanatomical changes observed in capsaicin-treated rats, as well as the reduced cutaneous plasma extravasation responses, indicate that the role of TRPV1 channels in schizophrenia is worthy of investigation.	Capsaicin	59-68	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	174-179
25279551-4	2014	The number of Fos-IR cells was significantly larger in M1 CFA and masseter (Mass) capsaicin applied (M1 CFA/Mass cap) rats compared with M1 veh/Mass veh rats in the contralateral Vc and Vi/Vc.	Capsaicin	82-91	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	14-17
25147231-2	2014	Enzyme-linked immunoassay showed that activation of intramural afferents by antidromic electrical stimulation or by capsaicin released SP and CGRP from human and guinea pig intestinal segments.	Capsaicin	116-125	calcitonin related polypeptide alpha	Homo sapiens	142-146
25147231-5	2014	Capsaicin evoked slow EPSP-like responses that were suppressed by antagonists for protease-activated receptor 2.	Capsaicin	0-9	F2R like trypsin receptor 1	Homo sapiens	82-111
25147231-7	2014	Histamine and mast cell protease II were released by 1) exposure to SP or CGRP, 2) capsaicin, 3) compound 48/80, 4) elevation of mast cell Ca2+ by ionophore A23187, and 5) antidromic electrical stimulation of afferents.	Capsaicin	83-92	calcitonin related polypeptide beta	Homo sapiens	74-81
25289759-10	2014	Capsaicin reduced the mRNA levels of tissue inhibitors of metalloproteinase 1 (TIMP-1) and transforming growth factor-beta1 (TGF-beta1) in HSCs.	Capsaicin	0-9	TIMP metallopeptidase inhibitor 1	Rattus norvegicus	79-85
25289759-10	2014	Capsaicin reduced the mRNA levels of tissue inhibitors of metalloproteinase 1 (TIMP-1) and transforming growth factor-beta1 (TGF-beta1) in HSCs.	Capsaicin	0-9	transforming growth factor, beta 1	Rattus norvegicus	91-123
25289759-10	2014	Capsaicin reduced the mRNA levels of tissue inhibitors of metalloproteinase 1 (TIMP-1) and transforming growth factor-beta1 (TGF-beta1) in HSCs.	Capsaicin	0-9	transforming growth factor, beta 1	Rattus norvegicus	125-134
25289759-11	2014	Moreover, capsaicin-induced cell apoptosis was associated with increased expression of Bax, cytochrome c (cyt c), and caspase-3, but reduced levels of Bcl-2.	Capsaicin	10-19	BCL2 associated X, apoptosis regulator	Rattus norvegicus	87-90
25289759-11	2014	Moreover, capsaicin-induced cell apoptosis was associated with increased expression of Bax, cytochrome c (cyt c), and caspase-3, but reduced levels of Bcl-2.	Capsaicin	10-19	caspase 3	Rattus norvegicus	118-127
25289759-11	2014	Moreover, capsaicin-induced cell apoptosis was associated with increased expression of Bax, cytochrome c (cyt c), and caspase-3, but reduced levels of Bcl-2.	Capsaicin	10-19	BCL2, apoptosis regulator	Rattus norvegicus	151-156
25104469-9	2014	Activation of TRPV1 or TRPV2 in distinct sets of primary afferents increased the sEPSC frequencies in a largely common population of DH neurons in laminae III-V, and might underlie the development of mechanical hypersensitivity following probenecid or capsaicin treatment.	Capsaicin	252-261	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
25048575-1	2014	OBJECTIVE: Pituitary adenylate cyclase-activating polypeptide (PACAP) expressed in capsaicin-sensitive sensory neurons and immune cells has divergent functions in inflammatory and pain processes.	Capsaicin	83-92	adenylate cyclase activating polypeptide 1	Mus musculus	11-61
25048575-1	2014	OBJECTIVE: Pituitary adenylate cyclase-activating polypeptide (PACAP) expressed in capsaicin-sensitive sensory neurons and immune cells has divergent functions in inflammatory and pain processes.	Capsaicin	83-92	adenylate cyclase activating polypeptide 1	Mus musculus	63-68
25104469-9	2014	Activation of TRPV1 or TRPV2 in distinct sets of primary afferents increased the sEPSC frequencies in a largely common population of DH neurons in laminae III-V, and might underlie the development of mechanical hypersensitivity following probenecid or capsaicin treatment.	Capsaicin	252-261	transient receptor potential cation channel, subfamily V, member 2	Rattus norvegicus	23-28
25219630-0	2014	Glucuronidation of capsaicin by liver microsomes and expressed UGT enzymes: reaction kinetics, contribution of individual enzymes and marked species differences.	Capsaicin	19-28	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	63-66
25219630-1	2014	OBJECTIVE: The objectives of this study are to characterize capsaicin glucuronidation using liver microsomes and to determine the contribution of individual UDP-glucuronosyltransferase (UGT) enzymes to hepatic glucuronidation of capsaicin.	Capsaicin	229-238	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	157-184
25219630-1	2014	OBJECTIVE: The objectives of this study are to characterize capsaicin glucuronidation using liver microsomes and to determine the contribution of individual UDP-glucuronosyltransferase (UGT) enzymes to hepatic glucuronidation of capsaicin.	Capsaicin	229-238	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	186-189
25219630-4	2014	Determination of the relative activity factors, expression-activity correlation and activity correlation analysis were performed to identify the main UGT enzymes contributing to capsaicin metabolism.	Capsaicin	178-187	UDP glucuronosyltransferase family 1 member A complex locus	Homo sapiens	150-153
25219630-7	2014	Capsaicin glucuronidation was significantly correlated with 3-O-glucuronidation of beta-estradiol (r = 0.637; p = 0.014) and with UGT1A1 protein levels (r = 0.616; p = 0.019) in a bank of individual HLMs (n = 14).	Capsaicin	0-9	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	130-136
25219630-8	2014	Also, capsaicin glucuronidation was strongly correlated with zidovudine glucuronidation (r = 0.765; p &lt; 0.01) and with UGT2B7 protein levels (r = 0.721; p &lt; 0.01).	Capsaicin	6-15	UDP glucuronosyltransferase family 2 member B7	Homo sapiens	122-128
25219630-9	2014	UGT1A1, 1A9 and 2B7 contributed 30.3, 6.0 and 49.0% of total glucuronidation of capsaicin in pHLM, respectively.	Capsaicin	80-89	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	0-6
25219630-11	2014	CONCLUSION: Capsaicin was subjected to significant hepatic glucuronidation, wherein UGT1A1 and 2B7 were the main contributing enzymes.	Capsaicin	12-21	UDP glucuronosyltransferase family 1 member A1	Homo sapiens	84-98
25128576-3	2014	1-Oleoyl-2acetyl-sn-glycerol (OAG), a TRPC agonist, elicited responses in 36% of OA-NO2-sensitive neurons while capsaicin (TRPV1 agonist) or allyl-isothiocyanate (AITC, TRPA1 agonist) elicited responses in only 16% and 10%, respectively, of these neurons.	Capsaicin	112-121	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	123-128
25167771-0	2014	Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients.	Capsaicin	0-9	TNF superfamily member 13b	Homo sapiens	37-41
25167771-0	2014	Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients.	Capsaicin	0-9	immunoglobulin heavy constant alpha 1	Homo sapiens	70-74
25167771-0	2014	Capsaicin induces high expression of BAFF and aberrantly glycosylated IgA1 of tonsillar mononuclear cells in IgA nephropathy patients.	Capsaicin	0-9	IGAN1	Homo sapiens	109-124
25167771-3	2014	It can be assumed that capsaicin, the active ingredient of hot pepper, is a possible risk factor in diet in the pathogenesis of IgAN.	Capsaicin	23-32	IGAN1	Homo sapiens	128-132
25167771-6	2014	RESULTS: In the absence and presence of capsaicin, the BAFF expression and IgA1 secretion were higher in IgAN patients than that in non-IgAN patients, meanwhile, the gene expression of C1GALT1 and Cosmc and IgA1 O-glycosylation level were significantly lower.	Capsaicin	40-49	TNF superfamily member 13b	Homo sapiens	55-59
25167771-6	2014	RESULTS: In the absence and presence of capsaicin, the BAFF expression and IgA1 secretion were higher in IgAN patients than that in non-IgAN patients, meanwhile, the gene expression of C1GALT1 and Cosmc and IgA1 O-glycosylation level were significantly lower.	Capsaicin	40-49	immunoglobulin heavy constant alpha 1	Homo sapiens	75-79
25167771-6	2014	RESULTS: In the absence and presence of capsaicin, the BAFF expression and IgA1 secretion were higher in IgAN patients than that in non-IgAN patients, meanwhile, the gene expression of C1GALT1 and Cosmc and IgA1 O-glycosylation level were significantly lower.	Capsaicin	40-49	IGAN1	Homo sapiens	105-109
25167771-6	2014	RESULTS: In the absence and presence of capsaicin, the BAFF expression and IgA1 secretion were higher in IgAN patients than that in non-IgAN patients, meanwhile, the gene expression of C1GALT1 and Cosmc and IgA1 O-glycosylation level were significantly lower.	Capsaicin	40-49	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	185-192
25167771-6	2014	RESULTS: In the absence and presence of capsaicin, the BAFF expression and IgA1 secretion were higher in IgAN patients than that in non-IgAN patients, meanwhile, the gene expression of C1GALT1 and Cosmc and IgA1 O-glycosylation level were significantly lower.	Capsaicin	40-49	C1GALT1 specific chaperone 1	Homo sapiens	197-202
25167771-7	2014	In IgAN group, coincubated with capsaicin, IgA1 and BAFF secretion and BAFF expression by TMCs were significantly higher than that without capsaicin, furthermore, the level of mRNA encoding C1GALT1 and Cosmc and the level of IgA1 O-glycosylation were evidently lower.	Capsaicin	32-41	IGAN1	Homo sapiens	3-7
25167771-7	2014	In IgAN group, coincubated with capsaicin, IgA1 and BAFF secretion and BAFF expression by TMCs were significantly higher than that without capsaicin, furthermore, the level of mRNA encoding C1GALT1 and Cosmc and the level of IgA1 O-glycosylation were evidently lower.	Capsaicin	32-41	C1GALT1 specific chaperone 1	Homo sapiens	202-207
25167771-7	2014	In IgAN group, coincubated with capsaicin, IgA1 and BAFF secretion and BAFF expression by TMCs were significantly higher than that without capsaicin, furthermore, the level of mRNA encoding C1GALT1 and Cosmc and the level of IgA1 O-glycosylation were evidently lower.	Capsaicin	32-41	immunoglobulin heavy constant alpha 1	Homo sapiens	225-229
25167771-7	2014	In IgAN group, coincubated with capsaicin, IgA1 and BAFF secretion and BAFF expression by TMCs were significantly higher than that without capsaicin, furthermore, the level of mRNA encoding C1GALT1 and Cosmc and the level of IgA1 O-glycosylation were evidently lower.	Capsaicin	139-148	IGAN1	Homo sapiens	3-7
25167771-8	2014	CONCLUSION: Capsaicin may induce IgA1 secretion by activating BAFF expression, and bring to aberrantly IgA1 O-glycosylation by suppressing C1GALT1 and Cosmc expression.	Capsaicin	12-21	immunoglobulin heavy constant alpha 1	Homo sapiens	33-37
25167771-8	2014	CONCLUSION: Capsaicin may induce IgA1 secretion by activating BAFF expression, and bring to aberrantly IgA1 O-glycosylation by suppressing C1GALT1 and Cosmc expression.	Capsaicin	12-21	TNF superfamily member 13b	Homo sapiens	62-66
25167771-8	2014	CONCLUSION: Capsaicin may induce IgA1 secretion by activating BAFF expression, and bring to aberrantly IgA1 O-glycosylation by suppressing C1GALT1 and Cosmc expression.	Capsaicin	12-21	immunoglobulin heavy constant alpha 1	Homo sapiens	103-107
25167771-8	2014	CONCLUSION: Capsaicin may induce IgA1 secretion by activating BAFF expression, and bring to aberrantly IgA1 O-glycosylation by suppressing C1GALT1 and Cosmc expression.	Capsaicin	12-21	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Homo sapiens	139-146
25167771-8	2014	CONCLUSION: Capsaicin may induce IgA1 secretion by activating BAFF expression, and bring to aberrantly IgA1 O-glycosylation by suppressing C1GALT1 and Cosmc expression.	Capsaicin	12-21	C1GALT1 specific chaperone 1	Homo sapiens	151-156
24446239-7	2014	Furthermore, here we show that capsaicin-induced CGRP release from mesenteric perivascular sensory nerves induces pannexin-1-formed channel opening, which in turn leads to reduction of pannexin-1 and endothelial nitric oxide synthase (eNOS) expression along the time.	Capsaicin	31-40	calcitonin related polypeptide alpha	Homo sapiens	49-53
24446239-7	2014	Furthermore, here we show that capsaicin-induced CGRP release from mesenteric perivascular sensory nerves induces pannexin-1-formed channel opening, which in turn leads to reduction of pannexin-1 and endothelial nitric oxide synthase (eNOS) expression along the time.	Capsaicin	31-40	pannexin 1	Homo sapiens	114-124
24446239-7	2014	Furthermore, here we show that capsaicin-induced CGRP release from mesenteric perivascular sensory nerves induces pannexin-1-formed channel opening, which in turn leads to reduction of pannexin-1 and endothelial nitric oxide synthase (eNOS) expression along the time.	Capsaicin	31-40	pannexin 1	Homo sapiens	185-195
24446239-7	2014	Furthermore, here we show that capsaicin-induced CGRP release from mesenteric perivascular sensory nerves induces pannexin-1-formed channel opening, which in turn leads to reduction of pannexin-1 and endothelial nitric oxide synthase (eNOS) expression along the time.	Capsaicin	31-40	nitric oxide synthase 3	Homo sapiens	200-233
24446239-8	2014	Interestingly, blockade of CGRP receptors with CGRP8-37 increased eNOS expression by ~5-fold, suggesting that capsaicin-sensitive sensory nerves are involved in the control of key signaling proteins for vascular function.	Capsaicin	110-119	calcitonin related polypeptide alpha	Homo sapiens	27-31
24604356-7	2014	Truncation of syntaxin 1 by BoNT/C1 caused /A- and/or /C1-truncated SNAP-25 to appear in non-functional complexes and blocked the release of calcitonin gene-related peptide (CGRP) elicited by capsaicin, ionomycin, thapsigargin or K(+) depolarization.	Capsaicin	192-201	synaptosome associated protein 25	Rattus norvegicus	68-75
24604356-7	2014	Truncation of syntaxin 1 by BoNT/C1 caused /A- and/or /C1-truncated SNAP-25 to appear in non-functional complexes and blocked the release of calcitonin gene-related peptide (CGRP) elicited by capsaicin, ionomycin, thapsigargin or K(+) depolarization.	Capsaicin	192-201	calcitonin-related polypeptide alpha	Rattus norvegicus	141-172
24604356-7	2014	Truncation of syntaxin 1 by BoNT/C1 caused /A- and/or /C1-truncated SNAP-25 to appear in non-functional complexes and blocked the release of calcitonin gene-related peptide (CGRP) elicited by capsaicin, ionomycin, thapsigargin or K(+) depolarization.	Capsaicin	192-201	calcitonin-related polypeptide alpha	Rattus norvegicus	174-178
24604356-9	2014	Inhibition of CGRP release by BoNT/A was reversed by capsaicin and/or ionomycin, an effect overcome by BoNT/C1.	Capsaicin	53-62	calcitonin-related polypeptide alpha	Rattus norvegicus	14-18
25342957-4	2014	METHODS: Capsaicin solutions were created at concentrations ranging from 0 to 500 muM in a variety of solvent systems, with and without Tween.	Capsaicin	9-18	latexin	Homo sapiens	82-85
24887171-2	2014	Although first studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 has been recently recognized to have a broader distribution in the central nervous system, where it is likely to constitute an atypical neurotransmission system involved in several functions through modulation of both neuronal and glial activities.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
24863039-0	2014	New insights into mechanisms of opioid inhibitory effects on capsaicin-induced TRPV1 activity during painful diabetic neuropathy.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
24863039-2	2014	Since mu-opioid receptor (MOR) activation can inhibit the transient receptor potential vanilloid 1 (TRPV1) activity in peripherally sensory neurons, this study investigated the mechanisms of impaired opioid inhibitory effects on capsaicin-induced TRPV1 activity in painful diabetic neuropathy.	Capsaicin	229-238	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	247-252
24863039-4	2014	In these animals, local morphine"s inhibitory effects on capsaicin-induced nocifensive behavior as well as on capsaicin-induced TRPV1 current in dorsal root ganglion cells were significantly impaired.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	128-133
24863039-6	2014	Intrathecal delivery of nerve growth factor in diabetic animals normalized sensory neuron MOR and subsequently rescued morphine"s inhibitory effects on capsaicin-induced TRPV1 activity in vivo and in vitro.	Capsaicin	152-161	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	170-175
24863039-7	2014	These findings identify a loss in functional MOR on sensory neurons as a contributing factor for the impaired opioid inhibitory effects on capsaicin-induced TRPV1 activity during advanced STZ-induced diabetes.	Capsaicin	139-148	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	157-162
25263209-6	2014	Capsaicin, a TRPV1 agonist increased the frequency of miniature EPSCs in 50% of LepRb(EGFP) neurons without altering the frequency of miniature IPSCs in the DMV.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
25088915-4	2014	We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are present in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased the number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration).	Capsaicin	253-262	cannabinoid receptor 1 (brain)	Mus musculus	14-17
25088915-4	2014	We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are present in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased the number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration).	Capsaicin	253-262	nerve growth factor	Mus musculus	19-22
25088915-4	2014	We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are present in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased the number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration).	Capsaicin	253-262	neurotrophic tyrosine kinase, receptor, type 1	Mus musculus	51-55
25088915-4	2014	We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are present in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased the number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration).	Capsaicin	253-262	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	62-67
25088915-4	2014	We found that CB1, NGF receptor tyrosine kinase A (trkA), and TRPV1 are present in cultured adult mouse small- to medium-sized afferent neurons and treatment with NGF (100ng/ml) for 30 min significantly increased the number of neurons that responded to capsaicin (as indicated by increased intracellular Ca(2 +) concentration).	Capsaicin	253-262	nerve growth factor	Mus musculus	163-166
25088915-7	2014	Blocking PI3 kinase activity also attenuated the NGF-induced increase in the number of neurons that responded to capsaicin.	Capsaicin	113-122	nerve growth factor	Mus musculus	49-52
25222270-1	2014	Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
24966300-4	2014	The nicotinic ACh receptors (nAChRs) appear to be expressed by some group III-IV neurons since capsaicin (TRPV1) and/or ATP (P2X) induced current in 56% of ACh-responsive neurons.	Capsaicin	95-104	transient receptor potential cation channel subfamily V member 1	Homo sapiens	106-111
25255125-0	2014	The selective target of capsaicin on FASN expression and de novo fatty acid synthesis mediated through ROS generation triggers apoptosis in HepG2 cells.	Capsaicin	24-33	fatty acid synthase	Homo sapiens	37-41
25255125-3	2014	The use of capsaicin as a source for a new FASN inhibitor will provide new insight into its possible application as a selective anti-cancer therapy.	Capsaicin	11-20	fatty acid synthase	Homo sapiens	43-47
25255125-6	2014	Apoptotic induction by capsaicin was mediated by inhibition of FASN protein expression which was accompanied by decreasing its activity on the de novo fatty acid synthesis.	Capsaicin	23-32	fatty acid synthase	Homo sapiens	63-67
25255125-7	2014	The expression of FASN was higher in HepG2 cells than in normal hepatocytes that were resistant to undergoing apoptosis following capsaicin administration.	Capsaicin	130-139	fatty acid synthase	Homo sapiens	18-22
25255125-8	2014	Moreover, the inhibitory effect of capsaicin on FASN expression and activity was found to be mediated by an increase of intracellular reactive oxygen species (ROS) generation.	Capsaicin	35-44	fatty acid synthase	Homo sapiens	48-52
25255125-12	2014	Collectively, our results provide novel evidence that capsaicin exhibits a potent anti-cancer property by targeting FASN protein in HepG2 cells.	Capsaicin	54-63	fatty acid synthase	Homo sapiens	116-120
25222270-1	2014	Transient Receptor Potential Vanilloid 1 (TRPV1) subunits form a polymodal cation channel responsive to capsaicin, heat, acidity and endogenous metabolites of polyunsaturated fatty acids.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
25184332-4	2014	Intraplantar injection of capsaicin evoked comparable heat hyperalgesia and mechanical hypersensitivity in Nf1+/- and wild type mice of both genders.	Capsaicin	26-35	neurofibromin 1	Mus musculus	107-110
25188410-6	2014	As previously observed with cisplatin, oxaliplatin and carboplatin also increased DNA damage as indicated by an increase in phospho-H2AX and reduced the capsaicin-evoked release of CGRP from neuronal cultures.	Capsaicin	153-162	calcitonin-related polypeptide alpha	Rattus norvegicus	181-185
25062738-11	2014	In contrast, exposure to the TRPV1 agonist capsaicin or the TRPM8 agonist icilin had no effect on intracellular Ca(2+) concentration.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
24935430-1	2014	AIMS: The TRPV1, transient receptor potential vanilloid type 1, agonist capsaicin is considered to be beneficial for cardiovascular health because it dilates coronary arteries through an endothelial-dependent mechanism and may slow atheroma progression.	Capsaicin	72-81	transient receptor potential cation channel subfamily V member 1	Canis lupus familiaris	10-15
24935430-9	2014	Blockers of the TP receptor or TRPV1 significantly inhibited capsaicin effects, but these were still observed in the presence of 50 muM nifedipine and 70 mM KCl.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 1	Canis lupus familiaris	31-36
24792079-2	2014	TRPV1 is a Ca(2+) permeable and non-selective channel, gated by noxious heat, oxidative stress and capsaicin (CAP).	Capsaicin	99-108	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
24792079-2	2014	TRPV1 is a Ca(2+) permeable and non-selective channel, gated by noxious heat, oxidative stress and capsaicin (CAP).	Capsaicin	110-113	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
25139109-8	2014	Heterologous expression experiments in HEK293T cells indicated that TLR4 expression enhanced capsaicin-induced intracellular calcium signals and inward currents.	Capsaicin	93-102	toll like receptor 4	Homo sapiens	68-72
24870597-4	2014	miR-520a-5p expression was extremely downregulated in capsaicin-treated cells.	Capsaicin	54-63	membrane associated ring-CH-type finger 8	Homo sapiens	0-3
24870597-8	2014	Finally, we observed the effects of capsaicin following miR-520a-5p inhibitor transfection upon cell proliferation, apoptosis, and STAT3 expression levels.	Capsaicin	36-45	membrane associated ring-CH-type finger 8	Homo sapiens	56-59
24870597-8	2014	Finally, we observed the effects of capsaicin following miR-520a-5p inhibitor transfection upon cell proliferation, apoptosis, and STAT3 expression levels.	Capsaicin	36-45	signal transducer and activator of transcription 3	Homo sapiens	131-136
24870597-9	2014	We determined that, downregulation of miR-520a-5p affected the proliferation inhibition enhanced by capsaicin and reduced STAT3 mRNA and protein expression levels and increased apoptotic cell number.	Capsaicin	100-109	membrane associated ring-CH-type finger 8	Homo sapiens	38-41
24870597-10	2014	In summary, miR-520a-5p displays a therapeutic effect by targeting STAT3 and impacting the anticancer effects of capsaicin; whereas capsaicin, potentially through the miR-520a-5p/STAT3 interaction, induces apoptosis and inhibits K562 leukemic cell proliferation with need of further investigation.	Capsaicin	113-122	membrane associated ring-CH-type finger 8	Homo sapiens	12-15
24870597-10	2014	In summary, miR-520a-5p displays a therapeutic effect by targeting STAT3 and impacting the anticancer effects of capsaicin; whereas capsaicin, potentially through the miR-520a-5p/STAT3 interaction, induces apoptosis and inhibits K562 leukemic cell proliferation with need of further investigation.	Capsaicin	132-141	membrane associated ring-CH-type finger 8	Homo sapiens	167-170
24870597-10	2014	In summary, miR-520a-5p displays a therapeutic effect by targeting STAT3 and impacting the anticancer effects of capsaicin; whereas capsaicin, potentially through the miR-520a-5p/STAT3 interaction, induces apoptosis and inhibits K562 leukemic cell proliferation with need of further investigation.	Capsaicin	132-141	signal transducer and activator of transcription 3	Homo sapiens	179-184
25210474-7	2014	Endothelin-1 directly activates nociceptors and potentiates the effect of other algogens, including capsaicin, formalin, and arachidonic acid.	Capsaicin	100-109	endothelin 1	Homo sapiens	0-12
24468003-10	2014	Taken together, we propose that mithramycin-A directs an inhibitory effect on a subpopulation of capsaicin-responsive DRG neurons that utilize Sp1-like factors for TRPV1 expression.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	164-169
25011915-2	2014	Multiple compounds showed highly potent TRPV1 antagonism toward capsaicin comparable to previous lead 7.	Capsaicin	64-73	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-45
24878626-5	2014	Capsaicin is a known agonist of the TRPV1 receptor.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-41
25126967-6	2014	Exposing neuronal cultures grown in NGF to Epac2siRNAreduced the expression of Epac2, but not Epac1 and prevented the PGE2-induced augmentation of capsaicin and potassium-evoked CGRP release in sensory neurons and the PGE2-induced increase in the number of APs generated by a ramp of current.	Capsaicin	147-156	nerve growth factor	Rattus norvegicus	36-39
25126967-6	2014	Exposing neuronal cultures grown in NGF to Epac2siRNAreduced the expression of Epac2, but not Epac1 and prevented the PGE2-induced augmentation of capsaicin and potassium-evoked CGRP release in sensory neurons and the PGE2-induced increase in the number of APs generated by a ramp of current.	Capsaicin	147-156	Rap guanine nucleotide exchange factor 4	Rattus norvegicus	43-48
25126967-6	2014	Exposing neuronal cultures grown in NGF to Epac2siRNAreduced the expression of Epac2, but not Epac1 and prevented the PGE2-induced augmentation of capsaicin and potassium-evoked CGRP release in sensory neurons and the PGE2-induced increase in the number of APs generated by a ramp of current.	Capsaicin	147-156	Rap guanine nucleotide exchange factor 4	Rattus norvegicus	79-84
25126967-2	2014	When isolated sensory neurons are grown in the absence of added NGF, but not in cultures grown with 30 ng/ml NGF, inhibiting protein kinase A (PKA) activity blocks the ability of PGE2 to augment capsaicin-evoked release of the neuropeptide CGRP and to increase the number of action potentials (APs) evoked by a ramp of current.	Capsaicin	195-204	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	125-141
25126967-2	2014	When isolated sensory neurons are grown in the absence of added NGF, but not in cultures grown with 30 ng/ml NGF, inhibiting protein kinase A (PKA) activity blocks the ability of PGE2 to augment capsaicin-evoked release of the neuropeptide CGRP and to increase the number of action potentials (APs) evoked by a ramp of current.	Capsaicin	195-204	protein kinase cAMP-activated catalytic subunit alpha	Rattus norvegicus	143-146
25126967-2	2014	When isolated sensory neurons are grown in the absence of added NGF, but not in cultures grown with 30 ng/ml NGF, inhibiting protein kinase A (PKA) activity blocks the ability of PGE2 to augment capsaicin-evoked release of the neuropeptide CGRP and to increase the number of action potentials (APs) evoked by a ramp of current.	Capsaicin	195-204	calcitonin-related polypeptide alpha	Rattus norvegicus	240-244
24878626-0	2014	Capsaicin induces apoptosis in human small cell lung cancer via the TRPV6 receptor and the calpain pathway.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 6	Homo sapiens	68-73
24878626-6	2014	We observed that capsaicin-induced apoptosis in human SCLC cells was mediated via the TRPV receptor family; however it was independent of TRPV1.	Capsaicin	17-26	transient receptor potential cation channel subfamily V member 1	Homo sapiens	138-143
24878626-7	2014	Surprisingly, the apoptotic activity of capsaicin required the TRPV6 receptor.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 6	Homo sapiens	63-68
24878626-8	2014	Depletion of TRPV6 receptor by siRNA methodology abolished the apoptotic activity of capsaicin in SCLC cells.	Capsaicin	85-94	transient receptor potential cation channel subfamily V member 6	Homo sapiens	13-18
24878626-12	2014	The treatment of human SCLC cells with capsaicin increased the activity of calpain 1 and 2 by threefold relative to untreated SCLC cells.	Capsaicin	39-48	calpain 1	Homo sapiens	75-90
24878626-13	2014	Such calpain activation, in response to capsaicin, was downstream of the TRPV6 receptor.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 6	Homo sapiens	73-78
24839185-9	2014	Capsaicin treatment induced an increase in the levels of phosphorylated Akt and Erk1/2 at the end of capsaicin cream application.	Capsaicin	0-9	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
24842665-8	2014	In cytosolic-free Ca(2+) analyses, the neurons were stimulated with the TRPV1 channel agonist capsaicin, a pungent compound found in hot chili peppers.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	72-77
24889371-4	2014	The TRPV1 level was a determinant of cell death induced by capsaicin.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
24839185-9	2014	Capsaicin treatment induced an increase in the levels of phosphorylated Akt and Erk1/2 at the end of capsaicin cream application.	Capsaicin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	80-86
24889371-5	2014	A concentration response curve with varying TRPV1 expression levels identified the minimum level of TRPV1 required for capsaicin induced cell death.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-49
24889371-5	2014	A concentration response curve with varying TRPV1 expression levels identified the minimum level of TRPV1 required for capsaicin induced cell death.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	100-105
24839185-9	2014	Capsaicin treatment induced an increase in the levels of phosphorylated Akt and Erk1/2 at the end of capsaicin cream application.	Capsaicin	101-110	AKT serine/threonine kinase 1	Rattus norvegicus	72-75
24889371-7	2014	Cell death induced by capsaicin was necrotic and associated with up-regulation of c-Fos and RIP3.	Capsaicin	22-31	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	82-87
25135718-10	2014	(2) TRPV1 channel agonist, capsaicin, increased the Ca(2+) influx in a concentration-dependent manner (EC50=284.3+-58 nmol/L).	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
24889371-7	2014	Cell death induced by capsaicin was necrotic and associated with up-regulation of c-Fos and RIP3.	Capsaicin	22-31	receptor interacting serine/threonine kinase 3	Homo sapiens	92-96
24727435-5	2014	Fos expression was suppressed by 65-92% in capsaicin-treated animals, as was epinephrine (74%), norepinephrine (33%), and glucagon (47%).	Capsaicin	43-52	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	0-3
24890824-0	2014	Transient receptor potential vanilloid 1 activation by dietary capsaicin promotes urinary sodium excretion by inhibiting epithelial sodium channel alpha subunit-mediated sodium reabsorption.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
24890824-3	2014	The renal transient receptor potential vanilloid 1 (TRPV1) cation channel can be activated by its agonist capsaicin.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	10-50
24890824-3	2014	The renal transient receptor potential vanilloid 1 (TRPV1) cation channel can be activated by its agonist capsaicin.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
24890824-5	2014	Here, we report that TRPV1 activation by dietary capsaicin increased urinary sodium excretion through reducing sodium reabsorption in wild-type (WT) mice on a HS diet but not in TRPV1(-/-) mice.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	21-26
24890824-8	2014	In contrast, this capsaicin effect was absent in TRPV1(-/-) mice.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	49-54
24890824-10	2014	Additionally, ENaC activity and expression were suppressed by capsaicin-mediated TRPV1 activation in cultured M1-cortical collecting duct cells.	Capsaicin	62-71	sodium channel, nonvoltage-gated 1 alpha	Mus musculus	14-18
24890824-10	2014	Additionally, ENaC activity and expression were suppressed by capsaicin-mediated TRPV1 activation in cultured M1-cortical collecting duct cells.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	81-86
24890824-12	2014	It concludes that TRPV1 activation in the cortical collecting ducts by capsaicin increases urinary sodium excretion and avoids HS diet-induced hypertension through antagonizing alphaENaC-mediated urinary sodium reabsorption.	Capsaicin	71-80	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	18-23
25014536-5	2014	In this study, the inhibition properties of capsaicin against the slow cytosolic isoform hCA I, and the ubiquitous and dominant rapid cytosolic isozymes hCA II were studied.	Capsaicin	44-53	carbonic anhydrase 1	Homo sapiens	89-94
24793910-7	2014	Cleaved SNAP-25 in TNC disappeared after formalin-induced trigeminal ganglion ablation or capsaicin-induced sensory denervation.	Capsaicin	90-99	synaptosome associated protein 25	Rattus norvegicus	8-15
24793910-8	2014	Occurrence of cleaved SNAP-25 in TNC and BoNT/A antinociceptive activity in formalin-induced orofacial pain were prevented by denervation with capsaicin.	Capsaicin	143-152	synaptosome associated protein 25	Rattus norvegicus	22-29
24939242-14	2014	Of the patients 80 % for PLP and 50 % for both SP and PLP/SP expressed the wish to receive retreatment with capsaicin 8 % patches.	Capsaicin	108-117	proteolipid protein 1	Homo sapiens	54-60
25072597-8	2014	At lower doses, capsaicin inhibits lipid accumulation and stimulates TRPV1 gene expression, while at higher doses it enhances accumulation of lipids and suppresses expression of its receptor.	Capsaicin	16-25	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	69-74
25072597-16	2014	Capsaicin inhibits adipogenesis in 3T3-L1 via TRPV1 activation and induces brown-like phenotype whereas higher doses.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
24726707-3	2014	Pharmacokinetics of LPP1 and its ability to attenuate neurogenic pain caused by TRP agonists: capsaicin and allyl isothiocyanate (AITC) were also investigated.	Capsaicin	94-103	phospholipid phosphatase 1	Mus musculus	20-24
24792786-1	2014	Transient receptor potential vanilloid 1 (TRPV1) is a polymodal sensor that is activated by heat (&gt;43  C), acid, or capsaicin, the pungent ingredient of hot peppers.	Capsaicin	119-128	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
24726558-4	2014	We investigated the effects of four representative local anesthetics, lidocaine, tetracaine, levobupivacaine, and ropivacaine on ERK phosphorylation induced by capsaicin, which releases glutamate from presynaptic neurons, NMDA, AMPA, or ionomycin, a calcium ionophore, in dorsal neurons.	Capsaicin	160-169	Eph receptor B1	Rattus norvegicus	129-132
24726558-5	2014	We observed capsaicin-induced phosphorylation of ERK, which was suppressed by lidocaine, tetracaine, or ropivacaine, but not by levobupivacaine.	Capsaicin	12-21	Eph receptor B1	Rattus norvegicus	49-52
24666696-1	2014	BACKGROUND: Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both animals and human subjects through activation of transient receptor potential vanilloid 1 (TRPV1) on airway sensory nerves.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	145-185
24666696-1	2014	BACKGROUND: Inhalation of capsaicin, the extract of hot chili peppers, induces coughing in both animals and human subjects through activation of transient receptor potential vanilloid 1 (TRPV1) on airway sensory nerves.	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	187-192
24726707-12	2014	LPP1 reduced pain induced by capsaicin (51%; p&lt;0.01) and AITC (41%; p&lt;0.05).	Capsaicin	29-38	phospholipid phosphatase 1	Mus musculus	0-4
24941071-3	2014	TRPV1 modulation was assessed in TRPV1-expressing Xenopus oocytes against capsaicin and low pH-induced current.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	0-5
24962708-6	2014	Inflammatory stimuli stimulated actin polymerization and enhanced the response of the cation channel TRPV1 (transient receptor potential V1) to capsaicin in DRG neurons, effects that were reversed by the knockdown of LIMK or preventing cofilin phosphorylation.	Capsaicin	144-153	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	101-106
24962708-6	2014	Inflammatory stimuli stimulated actin polymerization and enhanced the response of the cation channel TRPV1 (transient receptor potential V1) to capsaicin in DRG neurons, effects that were reversed by the knockdown of LIMK or preventing cofilin phosphorylation.	Capsaicin	144-153	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	108-139
24941071-3	2014	TRPV1 modulation was assessed in TRPV1-expressing Xenopus oocytes against capsaicin and low pH-induced current.	Capsaicin	74-83	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	33-38
24747365-0	2014	An exploration of the estrogen receptor transcription activity of capsaicin analogues via an integrated approach based on in silico prediction and in vitro assays.	Capsaicin	66-75	estrogen receptor 1	Homo sapiens	22-39
24704373-1	2014	Capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, has been reported to protect against ischemia-reperfusion injury in various organs, including the brain, heart, and kidney, whereas activation of TRPV1 was also reported to contribute to neurodegeneration, including pressure-induced retinal ganglion cell death in vitro.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-57
24704373-1	2014	Capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, has been reported to protect against ischemia-reperfusion injury in various organs, including the brain, heart, and kidney, whereas activation of TRPV1 was also reported to contribute to neurodegeneration, including pressure-induced retinal ganglion cell death in vitro.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
24747365-4	2014	Molecular simulation and the agonist/antagonist differential-docking screening identified 6-iodonordihydrocapsaicin (6-I-CPS) as a weak ERalpha agonist, while anti-estrogenicity was expected for N-arachidonoyldopamine, capsazepine, dihydrocapsaicin, trichostatin A, and capsaicin.	Capsaicin	106-115	estrogen receptor 1	Homo sapiens	136-143
24704373-1	2014	Capsaicin, a transient receptor potential vanilloid type1 (TRPV1) agonist, has been reported to protect against ischemia-reperfusion injury in various organs, including the brain, heart, and kidney, whereas activation of TRPV1 was also reported to contribute to neurodegeneration, including pressure-induced retinal ganglion cell death in vitro.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	221-226
24747365-8	2014	This finding suggested that the ER transcription activity of capsaicin analogues is generated at least partly through the ERalpha-mediated pathway.	Capsaicin	61-70	estrogen receptor 1	Homo sapiens	122-129
24926985-0	2014	Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis.	Capsaicin	0-9	tumor protein p53	Homo sapiens	32-35
24808184-2	2014	TRPV1 is a polymodal channel activated by noxious heat, capsaicin, and protons.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
24746025-0	2014	Neonatal capsaicin treatment in rats affects TRPV1-related noxious heat sensation and circadian body temperature rhythm.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	45-50
24746025-1	2014	The transient receptor potential vanilloid 1 (TRPV1) is a cation channel that serves as a polymodal detector of noxious stimuli such as capsaicin.	Capsaicin	136-145	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-44
24746025-1	2014	The transient receptor potential vanilloid 1 (TRPV1) is a cation channel that serves as a polymodal detector of noxious stimuli such as capsaicin.	Capsaicin	136-145	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	46-51
24746025-2	2014	Therefore, capsaicin treatment has been used to investigate the physiological function of TRPV1.	Capsaicin	11-20	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	90-95
24746025-8	2014	Neonatal capsaicin treatment not only decreased TRPV1 expression but also induced desensitization to noxious heat stimuli.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	48-53
24926985-0	2014	Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis.	Capsaicin	0-9	BTG3 associated nuclear protein	Homo sapiens	36-41
24926985-0	2014	Capsaicin-induced activation of p53-SMAR1 auto-regulatory loop down-regulates VEGF in non-small cell lung cancer to restrain angiogenesis.	Capsaicin	0-9	vascular endothelial growth factor A	Homo sapiens	78-82
24926985-3	2014	Our results propose the effectiveness of capsaicin in down-regulating VEGF expression in non-small cell lung carcinoma (NSCLC) cells in hypoxic environment.	Capsaicin	41-50	vascular endothelial growth factor A	Homo sapiens	70-74
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	tumor protein p53	Homo sapiens	33-36
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	BTG3 associated nuclear protein	Homo sapiens	37-42
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	tumor protein p53	Homo sapiens	94-97
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	107-117
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	BTG3 associated nuclear protein	Homo sapiens	134-139
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	162-167
24926985-4	2014	Capsaicin-treatment re-activated p53-SMAR1 positive feed-back loop in these cells to persuade p53-mediated HIF-1alpha degradation and SMAR1-induced repression of Cox-2 expression that restrained HIF-1alpha nuclear localization.	Capsaicin	0-9	hypoxia inducible factor 1 subunit alpha	Homo sapiens	195-205
24926985-6	2014	The above results advocate the candidature of capsaicin in exclusively targeting angiogenesis by down-regulating VEGF in tumor cells to achieve more efficient and cogent therapy of resistant NSCLC.	Capsaicin	46-55	vascular endothelial growth factor A	Homo sapiens	113-117
24612168-8	2014	Moreover, responses to the sodium-channel activator, veratridine, and the TRPV1 receptor agonist, capsaicin were preserved in GF mice relative to conventional tissues.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	74-79
24675661-7	2014	The activation of TRPV1 by voltage or ligands (capsaicin and 2-aminoethoxydiphenyl borate) is also potentiated by nicotinic acid.	Capsaicin	47-56	transient receptor potential cation channel subfamily V member 1	Homo sapiens	18-23
24391116-2	2014	Applied on the skin, capsaicin activates the transient receptor potential vanilloid type 1 (TRPV1) channel and releases CGRP from sensory nerve terminals, thus increasing dermal blood flow (DBF).	Capsaicin	21-30	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-90
24391116-2	2014	Applied on the skin, capsaicin activates the transient receptor potential vanilloid type 1 (TRPV1) channel and releases CGRP from sensory nerve terminals, thus increasing dermal blood flow (DBF).	Capsaicin	21-30	transient receptor potential cation channel subfamily V member 1	Homo sapiens	92-97
24391116-2	2014	Applied on the skin, capsaicin activates the transient receptor potential vanilloid type 1 (TRPV1) channel and releases CGRP from sensory nerve terminals, thus increasing dermal blood flow (DBF).	Capsaicin	21-30	calcitonin related polypeptide alpha	Homo sapiens	120-124
24676478-5	2014	Our results show that TRPV1 channels are not functional in insulin-secreting cells, since capsaicin did not produce current activation, not even under culture conditions known to induce the expression of other ion channels in these cells.	Capsaicin	90-99	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
24598529-8	2014	Activation of TRPV1 with capsaicin (100 nM) increased miniature EPSC (mEPSC) frequency in 70% of neurons, but half of these neurons had Low basal mEPSC rates and no temperature sensitivity.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
24788222-1	2014	BACKGROUND: Treatment with the TRPV1 agonist, capsaicin, was previously shown to protect against experimental colitis in the severe combined immunodeficiency (SCID) T-cell transfer model.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
24788222-2	2014	Here, we investigate trpv1 gene expression in lymphoid organs and cells from SCID and BALB/c mice to identify a potential target for the anti-inflammatory effect of capsaicin.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	21-26
24788222-3	2014	METHODS: The trpv1 expression was studied by real-time PCR in lymphoid tissues and gut of untreated and capsaicin-treated colitic SCID mice.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	13-18
24788222-6	2014	Capsaicin treatment in vivo attenuated T-cell transfer colitis and capsaicin in vitro also attenuated T-cell proliferation induced by enteroantigen, mitogen, and anti-CD3/CD28 beads in BALB/c, C57BL/6 mice, and B6.129X1-trpv1tm1Jul/J trpv1 knockout mice.	Capsaicin	0-9	CD3 antigen, epsilon polypeptide	Mus musculus	167-170
24788222-6	2014	Capsaicin treatment in vivo attenuated T-cell transfer colitis and capsaicin in vitro also attenuated T-cell proliferation induced by enteroantigen, mitogen, and anti-CD3/CD28 beads in BALB/c, C57BL/6 mice, and B6.129X1-trpv1tm1Jul/J trpv1 knockout mice.	Capsaicin	0-9	CD28 antigen	Mus musculus	171-175
24788222-6	2014	Capsaicin treatment in vivo attenuated T-cell transfer colitis and capsaicin in vitro also attenuated T-cell proliferation induced by enteroantigen, mitogen, and anti-CD3/CD28 beads in BALB/c, C57BL/6 mice, and B6.129X1-trpv1tm1Jul/J trpv1 knockout mice.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	220-225
24788222-6	2014	Capsaicin treatment in vivo attenuated T-cell transfer colitis and capsaicin in vitro also attenuated T-cell proliferation induced by enteroantigen, mitogen, and anti-CD3/CD28 beads in BALB/c, C57BL/6 mice, and B6.129X1-trpv1tm1Jul/J trpv1 knockout mice.	Capsaicin	67-76	CD3 antigen, epsilon polypeptide	Mus musculus	167-170
24788222-6	2014	Capsaicin treatment in vivo attenuated T-cell transfer colitis and capsaicin in vitro also attenuated T-cell proliferation induced by enteroantigen, mitogen, and anti-CD3/CD28 beads in BALB/c, C57BL/6 mice, and B6.129X1-trpv1tm1Jul/J trpv1 knockout mice.	Capsaicin	67-76	CD28 antigen	Mus musculus	171-175
24788222-6	2014	Capsaicin treatment in vivo attenuated T-cell transfer colitis and capsaicin in vitro also attenuated T-cell proliferation induced by enteroantigen, mitogen, and anti-CD3/CD28 beads in BALB/c, C57BL/6 mice, and B6.129X1-trpv1tm1Jul/J trpv1 knockout mice.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	220-225
24788222-8	2014	Likewise, enteroantigen- and mitogen-stimulated T cells from wild-type and trpv1 knockout mice were equally inhibited by capsaicin.	Capsaicin	121-130	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	75-80
24788222-10	2014	CONCLUSIONS: The trpv1 mRNA expression in lymphoid organs and the rectum of SCID mice suggests that the TRPV1 signaling in these organs could play a role in capsaicin-mediated attenuation of colitis.	Capsaicin	157-166	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	17-22
24788222-10	2014	CONCLUSIONS: The trpv1 mRNA expression in lymphoid organs and the rectum of SCID mice suggests that the TRPV1 signaling in these organs could play a role in capsaicin-mediated attenuation of colitis.	Capsaicin	157-166	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	104-109
24788222-11	2014	In addition, capsaicin-induced inhibition of T-cell proliferation of wild-type T cells lacking trpv1 expression suggests that capsaicin inhibits colitogenic T cells in a TRPV1 receptor-independent way, which might be linked to its anti-inflammatory effect.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
24747280-3	2014	Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as substance P (SP), calcitonin-gene related peptide (CGRP) and vasoactive intestinal peptide (VIP).	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	123-134
24788222-11	2014	In addition, capsaicin-induced inhibition of T-cell proliferation of wild-type T cells lacking trpv1 expression suggests that capsaicin inhibits colitogenic T cells in a TRPV1 receptor-independent way, which might be linked to its anti-inflammatory effect.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	170-175
24788222-11	2014	In addition, capsaicin-induced inhibition of T-cell proliferation of wild-type T cells lacking trpv1 expression suggests that capsaicin inhibits colitogenic T cells in a TRPV1 receptor-independent way, which might be linked to its anti-inflammatory effect.	Capsaicin	126-135	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
24788222-11	2014	In addition, capsaicin-induced inhibition of T-cell proliferation of wild-type T cells lacking trpv1 expression suggests that capsaicin inhibits colitogenic T cells in a TRPV1 receptor-independent way, which might be linked to its anti-inflammatory effect.	Capsaicin	126-135	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	170-175
24662320-2	2014	The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine.	Capsaicin	175-185	calcitonin-related polypeptide alpha	Rattus norvegicus	38-69
24662320-2	2014	The latter release sizable amounts of calcitonin gene-related peptide (CGRP); basal release can be stimulated by such secretagogues as high KCl concentrations, veratridine or capsaicine.	Capsaicin	175-185	calcitonin-related polypeptide alpha	Rattus norvegicus	71-75
24747280-3	2014	Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as substance P (SP), calcitonin-gene related peptide (CGRP) and vasoactive intestinal peptide (VIP).	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	136-138
24747280-3	2014	Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as substance P (SP), calcitonin-gene related peptide (CGRP) and vasoactive intestinal peptide (VIP).	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	141-172
24747280-3	2014	Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as substance P (SP), calcitonin-gene related peptide (CGRP) and vasoactive intestinal peptide (VIP).	Capsaicin	0-9	calcitonin related polypeptide alpha	Homo sapiens	174-178
24747280-3	2014	Capsaicin-sensitive sensory nerves which in nerve bladder extensively regulate immune system through neuropeptides such as substance P (SP), calcitonin-gene related peptide (CGRP) and vasoactive intestinal peptide (VIP).	Capsaicin	0-9	vasoactive intestinal peptide	Homo sapiens	215-218
23902373-7	2014	Like other TRPV1 agonists, several synthetic analogues could efficiently desensitize TRPV1 to activation by capsaicin.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	11-16
24980233-1	2014	BACKGROUND: Capsaicin, a prototypic transient receptor potential vanilloid 1 (TRPV1) agonist, has been shown to be more clinically effective in the treatment of nonallergic rhinitis (NAR) compared with other rhinitis subtypes.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	36-76
24980233-1	2014	BACKGROUND: Capsaicin, a prototypic transient receptor potential vanilloid 1 (TRPV1) agonist, has been shown to be more clinically effective in the treatment of nonallergic rhinitis (NAR) compared with other rhinitis subtypes.	Capsaicin	12-21	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
24980233-7	2014	RESULTS: Cath.a cells treated with azelastine, bepotastine, or capsaicin showed a significant increase in TRPV1-dependant (Ca(2+)) specific cytosolic fluorescence.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	106-111
24980233-8	2014	Continuous treatment with azelastine or capsaicin resulted in desensitization of TRPV1 channels.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	81-86
24861977-1	2014	Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids.	Capsaicin	131-140	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
24861977-1	2014	Transient receptor potential vanilloid 1 (TRPV1) is an ion channel present on sensory neurons which is activated by heat, protons, capsaicin and a variety of endogenous lipids termed endovanilloids.	Capsaicin	131-140	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
23902373-7	2014	Like other TRPV1 agonists, several synthetic analogues could efficiently desensitize TRPV1 to activation by capsaicin.	Capsaicin	108-117	transient receptor potential cation channel subfamily V member 1	Homo sapiens	85-90
23909699-0	2014	Inhibition of capsaicin-driven nasal hyper-reactivity by SB-705498, a TRPV1 antagonist.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
24674771-0	2014	Endothelin-1-induced priming to capsaicin in young animals.	Capsaicin	32-41	endothelin 1	Homo sapiens	0-12
24139494-0	2014	Capsaicin treatment reduces nasal hyperreactivity and transient receptor potential cation channel subfamily V, receptor 1 (TRPV1) overexpression in patients with idiopathic rhinitis.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	123-128
24139494-10	2014	Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment.	Capsaicin	153-162	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
24139494-10	2014	Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment.	Capsaicin	153-162	transient receptor potential cation channel subfamily M member 8	Homo sapiens	90-95
24139494-10	2014	Expression of TRPV1; transient receptor potential cation channel subfamily M, receptor 8 (TRPM8); and PGP 9.5 was only reduced in patients with IR after capsaicin treatment.	Capsaicin	153-162	ubiquitin C-terminal hydrolase L1	Homo sapiens	102-109
24139494-13	2014	Capsaicin exerts its therapeutic action by ablating the TRPV1-SP nociceptive signaling pathway in the nasal mucosa.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
24590823-0	2014	Inhibitory effects of capsaicin on voltage-gated potassium channels by TRPV1-independent pathway.	Capsaicin	22-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	71-76
24590823-1	2014	Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	41-81
24590823-1	2014	Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
24590823-1	2014	Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
24590823-1	2014	Previously we observed that capsaicin, a transient receptor potential vanilloid 1 (TRPV1) receptor activator, inhibited transient potassium current (IA) in capsaicin-sensitive and capsaicin-insensitive trigeminal ganglion (TG) neurons from rats.	Capsaicin	156-165	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-88
24590823-2	2014	It suggested that the inhibitory effects of capsaicin on IA have two different mechanisms: TRPV1-dependent and TRPV1-independent pathways.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
24590823-2	2014	It suggested that the inhibitory effects of capsaicin on IA have two different mechanisms: TRPV1-dependent and TRPV1-independent pathways.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	111-116
24590823-3	2014	The main purpose of this study is to further investigate the TRPV1-independent effects of capsaicin on voltage-gated potassium channels (VGPCs).	Capsaicin	90-99	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
24590823-9	2014	These results suggest that capsaicin inhibits the VGPCs through TRPV1-independent and PKA-dependent mechanisms, which may contribute to the capsaicin-induced nociception.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-69
24674771-2	2014	This study sought to examine the effect of ET-1 exposure in the neonatal period on subsequent contralateral capsaicin-induced secondary mechanical hyperalgesia.	Capsaicin	108-117	endothelin 1	Homo sapiens	43-47
24674771-9	2014	Priming with ET-1 on P7 led to a significant increase in capsaicin-induced Fos expression in the dorsal horn of the spinal cord in both males and females compared to controls (p&lt;0.001).	Capsaicin	57-66	endothelin 1	Homo sapiens	13-17
24674771-9	2014	Priming with ET-1 on P7 led to a significant increase in capsaicin-induced Fos expression in the dorsal horn of the spinal cord in both males and females compared to controls (p&lt;0.001).	Capsaicin	57-66	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	75-78
24548973-3	2014	Superfusion of the basilar artery with capsaicin, a selective TRPV1 receptor agonist, caused a transient relaxation, consistent with acute desensitization of neuronal TRPV1 channels.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-67
24548973-3	2014	Superfusion of the basilar artery with capsaicin, a selective TRPV1 receptor agonist, caused a transient relaxation, consistent with acute desensitization of neuronal TRPV1 channels.	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	167-172
24790204-6	2014	In contrast, direct gating of TRPM1 by capsaicin in RGS7(-/-)/RGS11(-/-) and WT rod BCs is similar, but severely compromised in Gpr179(nob5) rod BCs.	Capsaicin	39-48	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	30-35
24790204-6	2014	In contrast, direct gating of TRPM1 by capsaicin in RGS7(-/-)/RGS11(-/-) and WT rod BCs is similar, but severely compromised in Gpr179(nob5) rod BCs.	Capsaicin	39-48	regulator of G protein signaling 7	Mus musculus	52-56
24790204-6	2014	In contrast, direct gating of TRPM1 by capsaicin in RGS7(-/-)/RGS11(-/-) and WT rod BCs is similar, but severely compromised in Gpr179(nob5) rod BCs.	Capsaicin	39-48	regulator of G-protein signaling 11	Mus musculus	62-67
24790204-9	2014	In addition to its role in localizing RGS7 and RGS11 to the dendritic tips, GPR179 via a direct interaction with the TRPM1 channel alters its ability to be gated directly by capsaicin.	Capsaicin	174-183	G protein-coupled receptor 179	Mus musculus	76-82
24790204-9	2014	In addition to its role in localizing RGS7 and RGS11 to the dendritic tips, GPR179 via a direct interaction with the TRPM1 channel alters its ability to be gated directly by capsaicin.	Capsaicin	174-183	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	117-122
24599956-3	2014	We observed potentiation of capsaicin-activated TRPV1 currents by PI(4,5)P2 in the intracellular leaflet of the plasma membrane but inhibition of capsaicin-activated currents when PI(4,5)P2 was in both leaflets of the membrane, although much higher concentrations of PI(4,5)P2 in the extracellular leaflet were required for inhibition compared with the concentrations of PI(4,5)P2 in the intracellular leaflet that produced activation.	Capsaicin	28-37	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-53
24583041-6	2014	However, when neurons were excited by either alpha,beta-methyl-ATP to stimulate P2X3 receptors or capsaicin to activate transient receptor potential vanilloid (TRPV1) receptors, the firing threshold in KI neurons was significantly lowered and followed by a larger number of spikes.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	160-165
24916560-4	2014	Administration of CGH plus capsaicin, along with a HFD, led to significant decreases in body weight, fat mass, lipids in the liver, and plasma leptin as well as increases in plasma adiponectin.	Capsaicin	27-36	leptin	Rattus norvegicus	143-149
24916560-4	2014	Administration of CGH plus capsaicin, along with a HFD, led to significant decreases in body weight, fat mass, lipids in the liver, and plasma leptin as well as increases in plasma adiponectin.	Capsaicin	27-36	adiponectin, C1Q and collagen domain containing	Rattus norvegicus	181-192
24743737-4	2014	Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway.	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
24743737-4	2014	Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway.	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	273-278
24743737-4	2014	Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway.	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	273-278
24743737-4	2014	Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway.	Capsaicin	282-291	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
24743737-4	2014	Our study demonstrated that autophagy protected against foam cell formation in oxidized low-density lipoprotein (oxLDL)-treated VSMCs; activation of TRPV1 by capsaicin rescued the autophagy impaired by oxLDL and activated autophagy-lysosome pathway in VSMCs; activation of TRPV1 by capsaicin impeded foam cell formation of VSMCs through autophagy induction; activation of TRPV1 by capsaicin induced autophagy through AMP-activated protein kinase (AMPK) signaling pathway.	Capsaicin	282-291	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
24569998-6	2014	Site-directed mutagenesis studies revealed that imperatorin most likely acted via a site adjacent to or overlapping with the TRPV1 capsaicin-binding site.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	125-130
24716552-3	2014	RESULTS: Whole-cell patch-clamp recordings from pre-identified lamina I NK1R+ neurons, in rat spinal cord slices, revealed that chemerin significantly attenuates capsaicin potentiation of miniature excitatory postsynaptic current (mEPSC) frequency, but is without effect in non-potentiated conditions.	Capsaicin	162-171	retinoic acid receptor responder 2	Rattus norvegicus	128-136
24695785-1	2014	The transient receptor potential family V1 channel (TRPV1) is activated by multiple stimuli, including capsaicin, acid, endovanilloids, and heat (&gt;42C).	Capsaicin	103-112	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
24468031-9	2014	Rats in the OVx group consistently consumed significantly less capsaicin and exhibited significantly higher counts of capsaicin-evoked Fos-like immunoreactivity in the dorsomedial trigeminal subnucleus caudalis (Vc) compared to all other treatment groups.	Capsaicin	118-127	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	135-138
24699274-4	2014	Here, we report that inhalation of aerosolized 0.05% H2O2 for 90 s potentiated apneic responses to intravenous capsaicin (a TRPV1 receptor agonist), alpha,beta-methylene-ATP (a P2X receptor agonist), and phenylbiguanide (a 5-HT3 receptor agonist) in anesthetized rats.	Capsaicin	111-120	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	124-129
24699274-7	2014	The potentiating effect of H2O2 on the apneic responses to capsaicin was attenuated by HC-030031 (a TRPA1 receptor antagonist) and by iso-pyridoxalphosphate-6-azophenyl-2",5"-disulphonate (a P2X receptor antagonist).	Capsaicin	59-68	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	100-105
24495556-5	2014	TRPV1 agonist is capsaicine (1).	Capsaicin	17-27	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
24447516-7	2014	Supporting this, intracerebroventricular administration of AM404 or capsaicin produces antinociception that is lost in Ca(v)3.2(-/-) mice.	Capsaicin	68-77	calcium channel, voltage-dependent, T type, alpha 1H subunit	Mus musculus	119-127
24508775-5	2014	The antibody neutralized CGRP-mediated induction of cAMP in SK-N-MC cells in vitro and capsaicin-induced dermal blood flow in the rat.	Capsaicin	87-96	calcitonin related polypeptide alpha	Homo sapiens	25-29
24658439-9	2014	I/R damage potentiated by ADMA was exacerbated in capsaicin-denervated animals with a further reduction of CGRP.	Capsaicin	50-59	calcitonin-related polypeptide alpha	Rattus norvegicus	107-111
24705155-2	2014	Given that cigarette smoking triggers proinflammatory response via stimulation of the capsaicin-sensitive transient receptor potential cation channel TRPV1, this study was designed to evaluate the effect of an essential alpha,beta-unsaturated aldehyde from cigarette smoke crotonaldehyde on myocardial function and the underlying mechanism with a focus on TRPV1 and mitochondria.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	150-155
24495935-0	2014	Acetylsalicylic acid enhances tachyphylaxis of repetitive capsaicin responses in TRPV1-GFP expressing HEK293 cells.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
24495935-4	2014	Capsaicin dose-dependently increased intracellular calcium with an EC50 of 0.29 muM in rTRPV1 expressing HEK293 cells.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-93
24308840-7	2014	Mutations disrupting the capsaicin-binding site attenuated LE135 activation of TRPV1 channels and a single mutation (K170R) eliminated TRPA1 activity evoked by LE135.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	79-84
24612851-11	2014	However, only capsaicin, a TRPV1 agonist, replicated the analgesic effect of acupuncture when injected into ST36.	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	27-32
24419059-14	2014	Tumors from capsaicin-treated mice showed an increase in the phosphorylation of JNK, FOXO-1, BIM, and levels of CBP, cleavage of caspase-3, PARP, and decreased SirT-1 expression.	Capsaicin	12-21	sirtuin 1	Mus musculus	160-166
24210884-11	2014	In functional assays the TRPV1 agonist capsaicin induced dose-dependent IL-8 release, which could be blocked by the antagonist capsazepine.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-30
24374060-5	2014	Following paclitaxel treatment, the release of CGRP was determined using capsaicin, a TRPV1 agonist; allyl isothiocyanate (AITC), a TRPA1 agonist; or high extracellular potassium.	Capsaicin	73-82	calcitonin-related polypeptide alpha	Rattus norvegicus	47-51
24374060-7	2014	When neurons were stimulated with capsaicin or AITC, a low concentration of paclitaxel (10nM) augmented transmitter release, whereas a high concentration (300 nM) reduced transmitter release in a time-dependent manner; however, when high extracellular potassium was used as the evoking stimulus, all concentrations of paclitaxel augmented CGRP release from sensory neurons.	Capsaicin	34-43	calcitonin-related polypeptide alpha	Rattus norvegicus	339-343
24506933-5	2014	RESULTS: Inhaled tiotropium blocked cough and single C-fiber firing in the guinea pig to the transient receptor potential (TRP) V1 agonist capsaicin, a clinically relevant tussive stimulant.	Capsaicin	139-148	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	93-130
24419059-2	2014	Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3.6PL cells.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	35-51
24419059-2	2014	Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3.6PL cells.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	53-56
24419059-2	2014	Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3.6PL cells.	Capsaicin	0-9	forkhead box O1	Homo sapiens	103-108
24419059-15	2014	Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1.	Capsaicin	41-50	mitogen-activated protein kinase 8	Homo sapiens	61-64
24419059-2	2014	Capsaicin treatment phosphorylated c-jun-NH2-kinase (JNK); forkhead box transcription factor, class O (FOXO1); and BIM in BxPC-3, AsPC-1, and L3.6PL cells.	Capsaicin	0-9	BCL2 like 11	Homo sapiens	115-118
24419059-15	2014	Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1.	Capsaicin	41-50	forkhead box O1	Homo sapiens	69-75
24419059-3	2014	The expression of BIM increased in response to capsaicin treatment.	Capsaicin	47-56	BCL2 like 11	Homo sapiens	18-21
24419059-4	2014	Capsaicin treatment caused cleavage of caspase-3 and PARP, indicating apoptosis.	Capsaicin	0-9	caspase 3	Homo sapiens	39-48
24419059-15	2014	Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1.	Capsaicin	41-50	forkhead box O1	Homo sapiens	107-113
24419059-4	2014	Capsaicin treatment caused cleavage of caspase-3 and PARP, indicating apoptosis.	Capsaicin	0-9	collagen type XI alpha 2 chain	Homo sapiens	53-57
24419059-15	2014	Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1.	Capsaicin	41-50	CREB binding protein	Homo sapiens	122-125
24419059-5	2014	Antioxidants tiron and PEG-catalase blocked capsaicin-mediated JNK/FOXO/BIM activation and protected the cells from apoptosis.	Capsaicin	44-53	mitogen-activated protein kinase 8	Homo sapiens	63-66
24419059-15	2014	Taken together, our results suggest that capsaicin activated JNK and FOXO-1, leading to the acetylation of FOXO-1 through CBP and SirT-1.	Capsaicin	41-50	sirtuin 1	Homo sapiens	130-136
24419059-5	2014	Antioxidants tiron and PEG-catalase blocked capsaicin-mediated JNK/FOXO/BIM activation and protected the cells from apoptosis.	Capsaicin	44-53	BCL2 like 11	Homo sapiens	72-75
24419059-6	2014	Furthermore, capsaicin treatment caused a steady increase in the nuclear expression of FOXO-1, leading to increased DNA binding.	Capsaicin	13-22	forkhead box O1	Homo sapiens	87-93
24419059-7	2014	Capsaicin-mediated expression of BIM was found to be directly dependent on the acetylation of FOXO-1.	Capsaicin	0-9	BCL2 like 11	Homo sapiens	33-36
24419059-7	2014	Capsaicin-mediated expression of BIM was found to be directly dependent on the acetylation of FOXO-1.	Capsaicin	0-9	forkhead box O1	Homo sapiens	94-100
24419059-8	2014	The expression of CREB-binding protein (CBP) was increased, whereas SirT-1 was reduced by capsaicin treatment.	Capsaicin	90-99	sirtuin 1	Homo sapiens	68-74
24419059-9	2014	Using acetylation mimic or defective mutants, our result demonstrated that phosphorylation of FOXO-1 was mediated through acetylation by capsaicin treatment.	Capsaicin	137-146	forkhead box O1	Homo sapiens	94-100
24642709-0	2014	Capsaicin ameliorates cisplatin-induced renal injury through induction of heme oxygenase-1.	Capsaicin	0-9	heme oxygenase 1	Homo sapiens	74-90
24419059-10	2014	JNK inhibitor attenuated the phosphorylation of FOXO-1, activation of BIM, and abrogated capsaicin-induced apoptosis.	Capsaicin	89-98	mitogen-activated protein kinase 8	Homo sapiens	0-3
24419059-11	2014	Moreover, silencing FOXO1 by siRNA blocked capsaicin-mediated activation of BIM and apoptosis, whereas overexpression of FOXO-1 augmented its effects.	Capsaicin	43-52	forkhead box O1	Homo sapiens	20-25
24419059-11	2014	Moreover, silencing FOXO1 by siRNA blocked capsaicin-mediated activation of BIM and apoptosis, whereas overexpression of FOXO-1 augmented its effects.	Capsaicin	43-52	BCL2 like 11	Homo sapiens	76-79
24419059-12	2014	Silencing Bim drastically reduced capsaicin-mediated cleavage of caspase-3 and PARP, indicating the role of BIM in apoptosis.	Capsaicin	34-43	BCL2 like 11	Homo sapiens	10-13
24419059-12	2014	Silencing Bim drastically reduced capsaicin-mediated cleavage of caspase-3 and PARP, indicating the role of BIM in apoptosis.	Capsaicin	34-43	caspase 3	Homo sapiens	65-74
24419059-12	2014	Silencing Bim drastically reduced capsaicin-mediated cleavage of caspase-3 and PARP, indicating the role of BIM in apoptosis.	Capsaicin	34-43	collagen type XI alpha 2 chain	Homo sapiens	79-83
24419059-12	2014	Silencing Bim drastically reduced capsaicin-mediated cleavage of caspase-3 and PARP, indicating the role of BIM in apoptosis.	Capsaicin	34-43	BCL2 like 11	Homo sapiens	108-111
24642709-9	2014	We also found that capsaicin induces HO-1 expression in kidney tissues and HK-2 cells.	Capsaicin	19-28	heme oxygenase 1	Homo sapiens	37-41
24419059-14	2014	Tumors from capsaicin-treated mice showed an increase in the phosphorylation of JNK, FOXO-1, BIM, and levels of CBP, cleavage of caspase-3, PARP, and decreased SirT-1 expression.	Capsaicin	12-21	mitogen-activated protein kinase 8	Mus musculus	80-83
24419059-14	2014	Tumors from capsaicin-treated mice showed an increase in the phosphorylation of JNK, FOXO-1, BIM, and levels of CBP, cleavage of caspase-3, PARP, and decreased SirT-1 expression.	Capsaicin	12-21	forkhead box O1	Mus musculus	85-91
24642709-10	2014	Notably, the protective effects of capsaicin were completely abrogated by treatment with either the HO inhibitor ZnPP IX or HO-1 knockdown in HK-2 cells.	Capsaicin	35-44	heme oxygenase 1	Homo sapiens	124-128
24642709-11	2014	These results suggest that capsaicin has protective effects against cisplatin-induced renal dysfunction through induction of HO-1 as well as inhibition oxidative stress and inflammation.	Capsaicin	27-36	heme oxygenase 1	Homo sapiens	125-129
24419059-14	2014	Tumors from capsaicin-treated mice showed an increase in the phosphorylation of JNK, FOXO-1, BIM, and levels of CBP, cleavage of caspase-3, PARP, and decreased SirT-1 expression.	Capsaicin	12-21	BCL2-like 11 (apoptosis facilitator)	Mus musculus	93-96
24419059-14	2014	Tumors from capsaicin-treated mice showed an increase in the phosphorylation of JNK, FOXO-1, BIM, and levels of CBP, cleavage of caspase-3, PARP, and decreased SirT-1 expression.	Capsaicin	12-21	CREB binding protein	Mus musculus	112-115
24296036-4	2014	In addition, a significant decrease in the expression of lipoprotein lipase (LPL), leptin, PPARgamma, and C/EBPalpha was noted in 3T3-L1 preadipocytes when induced to differentiate by YCE and Capsaicin.	Capsaicin	192-201	lipoprotein lipase	Mus musculus	57-75
24419059-14	2014	Tumors from capsaicin-treated mice showed an increase in the phosphorylation of JNK, FOXO-1, BIM, and levels of CBP, cleavage of caspase-3, PARP, and decreased SirT-1 expression.	Capsaicin	12-21	caspase 3	Mus musculus	129-138
24419059-14	2014	Tumors from capsaicin-treated mice showed an increase in the phosphorylation of JNK, FOXO-1, BIM, and levels of CBP, cleavage of caspase-3, PARP, and decreased SirT-1 expression.	Capsaicin	12-21	poly (ADP-ribose) polymerase family, member 1	Mus musculus	140-144
24296036-4	2014	In addition, a significant decrease in the expression of lipoprotein lipase (LPL), leptin, PPARgamma, and C/EBPalpha was noted in 3T3-L1 preadipocytes when induced to differentiate by YCE and Capsaicin.	Capsaicin	192-201	CCAAT/enhancer binding protein (C/EBP), alpha	Mus musculus	106-116
24643130-6	2014	Through suppressing the interaction between p53 and MDM2, MDM2-mediated p53 ubiquitination was remarkably decreased after capsaicin treatment, which resulted in the stabilization and accumulation of p53.	Capsaicin	122-131	tumor protein p53	Homo sapiens	72-75
24749349-9	2014	Capsaicin pretreatment in CIR group increased lung wet/dry weight ratio and lung pathologic lesions, along with higher level of MDA and lower activity of SOD and CAT (P &lt; 0.05, vs. IR).	Capsaicin	0-9	catalase	Oryctolagus cuniculus	162-165
24643130-0	2014	Capsaicin mediates cell cycle arrest and apoptosis in human colon cancer cells via stabilizing and activating p53.	Capsaicin	0-9	tumor protein p53	Homo sapiens	110-113
24524628-5	2014	Neurotoxins isolectin B4-saporin (IB4-SAP), or capsaicin was injected intrathecally to selectively ablate IB4(+) neurons or TRPV1(+) neurons, respectively.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	124-129
24643130-3	2014	Here, we reported that capsaicin had a profound anti-proliferative effect on human colon cancer cells via inducing cell cycle G0/G1 phase arrest and apoptosis, which was associated with an increase of p21, Bax and cleaved PARP.	Capsaicin	23-32	H3 histone pseudogene 16	Homo sapiens	201-204
24643130-3	2014	Here, we reported that capsaicin had a profound anti-proliferative effect on human colon cancer cells via inducing cell cycle G0/G1 phase arrest and apoptosis, which was associated with an increase of p21, Bax and cleaved PARP.	Capsaicin	23-32	BCL2 associated X, apoptosis regulator	Homo sapiens	206-209
24643130-3	2014	Here, we reported that capsaicin had a profound anti-proliferative effect on human colon cancer cells via inducing cell cycle G0/G1 phase arrest and apoptosis, which was associated with an increase of p21, Bax and cleaved PARP.	Capsaicin	23-32	collagen type XI alpha 2 chain	Homo sapiens	222-226
24643130-4	2014	The underlying mechanism of capsaicin"s antitumor potency was mainly attributed to the stabilization and activation of p53.	Capsaicin	28-37	tumor protein p53	Homo sapiens	119-122
24643130-5	2014	Capsaicin substantially prolonged the half-life of p53 and significantly elevated the transcriptional activity of p53.	Capsaicin	0-9	tumor protein p53	Homo sapiens	51-54
24643130-5	2014	Capsaicin substantially prolonged the half-life of p53 and significantly elevated the transcriptional activity of p53.	Capsaicin	0-9	tumor protein p53	Homo sapiens	114-117
24643130-6	2014	Through suppressing the interaction between p53 and MDM2, MDM2-mediated p53 ubiquitination was remarkably decreased after capsaicin treatment, which resulted in the stabilization and accumulation of p53.	Capsaicin	122-131	tumor protein p53	Homo sapiens	44-47
24643130-6	2014	Through suppressing the interaction between p53 and MDM2, MDM2-mediated p53 ubiquitination was remarkably decreased after capsaicin treatment, which resulted in the stabilization and accumulation of p53.	Capsaicin	122-131	MDM2 proto-oncogene	Homo sapiens	52-56
24643130-6	2014	Through suppressing the interaction between p53 and MDM2, MDM2-mediated p53 ubiquitination was remarkably decreased after capsaicin treatment, which resulted in the stabilization and accumulation of p53.	Capsaicin	122-131	MDM2 proto-oncogene	Homo sapiens	58-62
24462040-1	2014	The peripheral terminals of primary nociceptive neurons play an essential role in pain detection mediated by membrane receptors like TRPV1, a molecular sensor of heat and capsaicin.	Capsaicin	171-180	transient receptor potential cation channel subfamily V member 1	Homo sapiens	133-138
24444609-2	2014	Here, we show that capsaicin-induced oxidative DNA damage culminates in p53 activation to up-regulate expression of miR-34a in non-small cell lung carcinoma (NSCLC) cells.	Capsaicin	19-28	tumor protein p53	Homo sapiens	72-75
24444609-2	2014	Here, we show that capsaicin-induced oxidative DNA damage culminates in p53 activation to up-regulate expression of miR-34a in non-small cell lung carcinoma (NSCLC) cells.	Capsaicin	19-28	microRNA 34a	Homo sapiens	116-123
24506953-7	2014	Capsaicin stimulation of TRPV1 provoked concentration-dependent CGRP release.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-30
24506953-7	2014	Capsaicin stimulation of TRPV1 provoked concentration-dependent CGRP release.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	64-68
24688365-9	2014	CONCLUSION: TRPV1 receptor is successfully stimulated by capsaicin, piperine, and natural capsaicinoids.	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
24688365-9	2014	CONCLUSION: TRPV1 receptor is successfully stimulated by capsaicin, piperine, and natural capsaicinoids.	Capsaicin	90-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
24643130-6	2014	Through suppressing the interaction between p53 and MDM2, MDM2-mediated p53 ubiquitination was remarkably decreased after capsaicin treatment, which resulted in the stabilization and accumulation of p53.	Capsaicin	122-131	tumor protein p53	Homo sapiens	72-75
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	129-138	tumor protein p53	Homo sapiens	15-18
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	129-138	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	129-138	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	129-138	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	15-18
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	15-18
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	62-65
24643130-7	2014	The results of p53-shRNA experiment further demonstrated that p53 knockdown severely impaired the sensitivity of tested cells to capsaicin, G0/G1 phase arrest and the apoptosis induced by capsaicin in p53-knockdown cells was also dramatically decreased, implicating the important role of p53 played in capsaicin"s antitumor activity.	Capsaicin	188-197	tumor protein p53	Homo sapiens	62-65
24524628-12	2014	Selective ablation of TRPV1(+) neurons by intrathecal capsaicin injection, or TRPV1 antagonism by JNJ-17203212 in the IB4-SAP treated mice completely reversed SCC-induced thermal hyperalgesia, without affecting mechanical allodynia.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	22-27
24119304-11	2014	beta-CD/EO-treated mice were also significantly (p &lt; 0.05 or p &lt; 0.001) protected against nociception induced by capsaicin and glutamate.	Capsaicin	119-128	beta-carotene oxygenase 1	Mus musculus	0-7
24337453-0	2014	Capsaicin induces apoptosis and modulates MAPK signaling in human gastric cancer cells.	Capsaicin	0-9	mitogen-activated protein kinase 3	Homo sapiens	42-46
24622825-6	2014	Similar results were obtained using mice lacking various EP receptor subtypes; i.e., PGE2 failed to provide both direct and adaptive cytoprotection in EP1 (-/-) mice, while capsaicin-induced protection was observed in EP1 (-/-) mice, but disappeared in IP (-/-) mice.	Capsaicin	173-182	prostaglandin E receptor 1 (subtype EP1)	Mus musculus	218-221
24337453-5	2014	Cleaved caspase-3 was increased and Bcl-2 was reduced by treatment with capsaicin in AGS cells.	Capsaicin	72-81	BCL2 apoptosis regulator	Homo sapiens	36-41
24337453-6	2014	Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells.	Capsaicin	0-9	mitogen-activated protein kinase 3	Homo sapiens	63-70
24337453-6	2014	Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells.	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	72-75
24337453-6	2014	Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells.	Capsaicin	0-9	mitogen-activated protein kinase 3	Homo sapiens	76-80
24337453-6	2014	Capsaicin treatment decreased the expression of phosphorylated ERK 1/2, p38 MAPK or JNK in AGS cells.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	84-87
24275229-1	2014	Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and chemicals such as capsaicin.	Capsaicin	154-163	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
24275229-1	2014	Transient receptor potential vanilloid 1 (TRPV1) is a nonselective ligand-gated cation channel responding to noxious heat, protons, and chemicals such as capsaicin.	Capsaicin	154-163	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
24466320-12	2014	Importantly, an increase in TRESK channel activity effectively inhibited capsaicin-evoked spikes in TG neurons.	Capsaicin	73-82	potassium channel, subfamily K, member 18	Mus musculus	28-33
24475113-6	2014	Association mapping results revealed Pun1 as a key regulator of major metabolites in the capsaicin pathway mainly affecting capsaicinoids and precursors for acyl moieties of capsaicinoids.	Capsaicin	89-98	acyltransferase Pun1	Capsicum annuum	37-41
24475113-6	2014	Association mapping results revealed Pun1 as a key regulator of major metabolites in the capsaicin pathway mainly affecting capsaicinoids and precursors for acyl moieties of capsaicinoids.	Capsaicin	124-137	acyltransferase Pun1	Capsicum annuum	37-41
24475113-6	2014	Association mapping results revealed Pun1 as a key regulator of major metabolites in the capsaicin pathway mainly affecting capsaicinoids and precursors for acyl moieties of capsaicinoids.	Capsaicin	174-187	acyltransferase Pun1	Capsicum annuum	37-41
24475113-7	2014	Six different SNPs in the promoter sequence of Pun1 were found associated with capsaicin in plants from both seasons.	Capsaicin	79-88	acyltransferase Pun1	Capsicum annuum	47-51
24475113-10	2014	Candidate gene association mapping of Pun1 suggested that the accumulation of capsaicinoids depends on the expression of Pun1, as revealed by the most important associated SNPs found in the promoter region of Pun1.	Capsaicin	78-91	acyltransferase Pun1	Capsicum annuum	38-42
24475113-10	2014	Candidate gene association mapping of Pun1 suggested that the accumulation of capsaicinoids depends on the expression of Pun1, as revealed by the most important associated SNPs found in the promoter region of Pun1.	Capsaicin	78-91	acyltransferase Pun1	Capsicum annuum	121-125
24475113-10	2014	Candidate gene association mapping of Pun1 suggested that the accumulation of capsaicinoids depends on the expression of Pun1, as revealed by the most important associated SNPs found in the promoter region of Pun1.	Capsaicin	78-91	acyltransferase Pun1	Capsicum annuum	121-125
24217926-9	2014	Capsaicin (a TRPV1 agonist) evoked constrictions in skeletal muscle arteries and in the carotid artery, but had no effect on the femoral and mesenteric arteries or the aorta.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
24140894-9	2014	We found that OEA antidyskinetic properties were mediated by TRPV1 receptor, as pretreatment with capsaicin, a TRPV1 agonist, blocked OEA antidyskinetic actions, as well as the reduction in FosB- and pAcH3-overexpression induced by L-DOPA.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	61-66
24140894-9	2014	We found that OEA antidyskinetic properties were mediated by TRPV1 receptor, as pretreatment with capsaicin, a TRPV1 agonist, blocked OEA antidyskinetic actions, as well as the reduction in FosB- and pAcH3-overexpression induced by L-DOPA.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	111-116
24140894-9	2014	We found that OEA antidyskinetic properties were mediated by TRPV1 receptor, as pretreatment with capsaicin, a TRPV1 agonist, blocked OEA antidyskinetic actions, as well as the reduction in FosB- and pAcH3-overexpression induced by L-DOPA.	Capsaicin	98-107	FBJ osteosarcoma oncogene B	Mus musculus	190-194
24231552-3	2014	The number of c-Fos-activated neurons in the dorsal horn was increased after hind paw injection of capsaicin, formalin or complete Freund"s adjuvant (CFA, 1.5 hrs - 4 days).	Capsaicin	99-108	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	14-19
24184981-4	2014	NPY decreased capsaicin-evoked SP-like immunoreactivity in the microdialysate of the dorsal horn.	Capsaicin	14-23	neuropeptide Y	Rattus norvegicus	0-3
24830013-14	2014	While receptors have been discovered for several individual chemicals:one example is the TrpV1 channel for the neurotoxin capsaicin:other mechanisms must be discovered to account for the effects of most painful and itchy substances.	Capsaicin	122-131	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
24830023-5	2014	The thermosensitive transient receptor potential (TRP) channels TRPV1 and TRPA1, which bind capsaicin and allyl isothiocyanate (mustard oil), respectively, are important for pain transmission.	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	64-69
24830023-5	2014	The thermosensitive transient receptor potential (TRP) channels TRPV1 and TRPA1, which bind capsaicin and allyl isothiocyanate (mustard oil), respectively, are important for pain transmission.	Capsaicin	92-101	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	74-79
24941663-8	2014	Neurogenic inflammation and the long-list of "capsaicin-sensitive" tissue responses are mediated by an unorthodox dual sensory-efferent function of peptidergic TRPV1-expressing nerve terminals which differ from the classical efferent and sensory nerve endings that have a unidirectional role in neuroregulation.	Capsaicin	46-55	transient receptor potential cation channel subfamily V member 1	Homo sapiens	160-165
24075930-1	2014	Capsaicin (CAP), the pungent ingredient of chili peppers, inhibits growth of various solid cancers via TRPV1 as well as TRPV1-independent mechanisms.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
24075930-1	2014	Capsaicin (CAP), the pungent ingredient of chili peppers, inhibits growth of various solid cancers via TRPV1 as well as TRPV1-independent mechanisms.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-125
23886380-6	2014	The administration of capsaicin as an agonist stimulus of TRPV1, a warm temperature receptor, decreased the delay in swallowing reflex.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
24299199-2	2014	Our objective was to use the epidermis as a relay for the induction of an electric current to the neurons following the topical application of capsaicin on the skin epidermis of the skin explant, an agonist of the TRPV1 channel implicated in pruritus and pain.	Capsaicin	143-152	transient receptor potential cation channel subfamily V member 1	Homo sapiens	214-219
24299199-3	2014	After 10-20 days of coculture to form the re-innervated skin model, we applied a solution of capsaicin directly on the epidermis of the skin explant (4 mum).	Capsaicin	93-102	latexin	Homo sapiens	152-155
24961971-6	2014	TRPV1 is a receptor for pungent chemical stimuli such as capsaicin and for several irritants (chemesthesis).	Capsaicin	57-66	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
24961985-5	2014	was isolated in 1846 and the receptor for the biological actions of capsaicin was cloned in 1997, which is now known as TRPV1 (transient receptor potential vanilloid 1).	Capsaicin	68-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	120-125
24961985-5	2014	was isolated in 1846 and the receptor for the biological actions of capsaicin was cloned in 1997, which is now known as TRPV1 (transient receptor potential vanilloid 1).	Capsaicin	68-77	transient receptor potential cation channel subfamily V member 1	Homo sapiens	127-167
24659662-7	2014	Increased mRNA expressions of caspase gene family members, activated caspase-3 and decreased mRNA and protein expression of BCL-2 gene indicated apoptotic response to capsaicin.	Capsaicin	167-176	BCL2 apoptosis regulator	Homo sapiens	124-129
24659662-8	2014	Moreover capsaicin treatment suppressed significantly the expression of the key cell signaling pathways of KRAS, AKT, GAB2, PTPN11, BRAF, INPP5D, MAPK7.	Capsaicin	9-18	KRAS proto-oncogene, GTPase	Homo sapiens	107-111
24659662-8	2014	Moreover capsaicin treatment suppressed significantly the expression of the key cell signaling pathways of KRAS, AKT, GAB2, PTPN11, BRAF, INPP5D, MAPK7.	Capsaicin	9-18	AKT serine/threonine kinase 1	Homo sapiens	113-116
24659662-8	2014	Moreover capsaicin treatment suppressed significantly the expression of the key cell signaling pathways of KRAS, AKT, GAB2, PTPN11, BRAF, INPP5D, MAPK7.	Capsaicin	9-18	GRB2 associated binding protein 2	Homo sapiens	118-122
24659662-8	2014	Moreover capsaicin treatment suppressed significantly the expression of the key cell signaling pathways of KRAS, AKT, GAB2, PTPN11, BRAF, INPP5D, MAPK7.	Capsaicin	9-18	protein tyrosine phosphatase non-receptor type 11	Homo sapiens	124-130
24659662-8	2014	Moreover capsaicin treatment suppressed significantly the expression of the key cell signaling pathways of KRAS, AKT, GAB2, PTPN11, BRAF, INPP5D, MAPK7.	Capsaicin	9-18	B-Raf proto-oncogene, serine/threonine kinase	Homo sapiens	132-136
24659662-8	2014	Moreover capsaicin treatment suppressed significantly the expression of the key cell signaling pathways of KRAS, AKT, GAB2, PTPN11, BRAF, INPP5D, MAPK7.	Capsaicin	9-18	inositol polyphosphate-5-phosphatase D	Homo sapiens	138-144
24659662-8	2014	Moreover capsaicin treatment suppressed significantly the expression of the key cell signaling pathways of KRAS, AKT, GAB2, PTPN11, BRAF, INPP5D, MAPK7.	Capsaicin	9-18	mitogen-activated protein kinase 7	Homo sapiens	146-151
24463108-4	2014	RESULTS: Selective activation of mGluR 7 of the VL-PAG by AMN082 obviously facilitated capsaicin (CAP)-induced CMR (P&lt;0.05), which was suppressed by DCPG-induced mGluR 8 activation (P&lt;0.05).	Capsaicin	87-96	glutamate receptor, ionotropic, kainate 3	Mus musculus	33-40
24463108-4	2014	RESULTS: Selective activation of mGluR 7 of the VL-PAG by AMN082 obviously facilitated capsaicin (CAP)-induced CMR (P&lt;0.05), which was suppressed by DCPG-induced mGluR 8 activation (P&lt;0.05).	Capsaicin	87-96	glutamate receptor, metabotropic 8	Mus musculus	165-172
24463108-4	2014	RESULTS: Selective activation of mGluR 7 of the VL-PAG by AMN082 obviously facilitated capsaicin (CAP)-induced CMR (P&lt;0.05), which was suppressed by DCPG-induced mGluR 8 activation (P&lt;0.05).	Capsaicin	98-101	glutamate receptor, ionotropic, kainate 3	Mus musculus	33-40
24463108-4	2014	RESULTS: Selective activation of mGluR 7 of the VL-PAG by AMN082 obviously facilitated capsaicin (CAP)-induced CMR (P&lt;0.05), which was suppressed by DCPG-induced mGluR 8 activation (P&lt;0.05).	Capsaicin	98-101	glutamate receptor, metabotropic 8	Mus musculus	165-172
24084605-10	2014	In UM cells, the CB1 agonist, WIN 55,212-2, induced Ca(2+) transients, which were suppressed by La(3+) and CPZ whereas CAP-induced Ca(2+) transients could also be suppressed by CB1 activation.	Capsaicin	119-122	cannabinoid receptor 1	Homo sapiens	17-20
24084605-10	2014	In UM cells, the CB1 agonist, WIN 55,212-2, induced Ca(2+) transients, which were suppressed by La(3+) and CPZ whereas CAP-induced Ca(2+) transients could also be suppressed by CB1 activation.	Capsaicin	119-122	cannabinoid receptor 1	Homo sapiens	177-180
25170901-4	2014	RESULTS: TRPV1 activation by capsaicin (CAP) and an increase in osmolarity to   450 mOsM both induced increases in Ca(2+) levels.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-14
24756725-2	2014	Since the discovery of the pain sensing, capsaicin- and heat-activated vanilloid receptor (TRPV1), TRP channels have been found to be involved in regulating almost all kinds of our sensory modalities.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	91-96
25138094-7	2014	In addition, several other drugs, such as resveratrol, berberine, statins, epigallocatechin gallate (EGCG) and capsaicin, have provided a similar capacity for tumor inhibition, and the anti-cancer effects of most of them were mainly the result of AMPK activation.	Capsaicin	111-120	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	247-251
25152753-2	2014	Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, exerts a protective role in cardiac remodeling that resulted from myocardial infarction, and peroxisome proliferation-activated receptors delta (PPAR-delta) play an important role in metabolic myocardium remodeling.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-45
25152753-2	2014	Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, exerts a protective role in cardiac remodeling that resulted from myocardial infarction, and peroxisome proliferation-activated receptors delta (PPAR-delta) play an important role in metabolic myocardium remodeling.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	47-52
25152753-2	2014	Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, exerts a protective role in cardiac remodeling that resulted from myocardial infarction, and peroxisome proliferation-activated receptors delta (PPAR-delta) play an important role in metabolic myocardium remodeling.	Capsaicin	79-88	peroxisome proliferator activator receptor delta	Mus musculus	235-245
25152753-7	2014	However, this effect of capsaicin was absent in TRPV1(-/-) mice on a high-salt diet.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	48-53
24941664-1	2014	The capsaicin receptor, transient receptor potential vanilloid type 1 ion channel (TRPV1), has been identified as a polymodal transducer molecule on a sub-set of primary sensory neurons which responds to various stimuli including noxious heat (&gt; -42 degrees C), protons and vanilloids such as capsaicin, the hot ingredient of chilli peppers.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	83-88
24941667-3	2014	Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and even, in sufficient dosing, to create long-term nerve terminal defunctionalization.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
24941667-3	2014	Capsaicin, a TRPV1 agonist, has been shown to induce a refractory period in the nerve terminal expressing TRPV1 and even, in sufficient dosing, to create long-term nerve terminal defunctionalization.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	106-111
24941668-1	2014	Capsaicin is a selective transient receptor potential vanilloid 1 (TRPV1) ion channel agonist and has been demonstrated to reduce nerve conduction of nociceptive C fibers in the trigeminal nerve without affecting conduction in Adelta fibers.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-65
24941668-1	2014	Capsaicin is a selective transient receptor potential vanilloid 1 (TRPV1) ion channel agonist and has been demonstrated to reduce nerve conduction of nociceptive C fibers in the trigeminal nerve without affecting conduction in Adelta fibers.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
24941668-5	2014	Rational approaches to treat the pathophysiology of NAR would be to develop therapies with selective TRPV1 agonist activity like capsaicin that target desensitization of TRP ion channels on sensory afferent nerves.	Capsaicin	129-138	transient receptor potential cation channel subfamily V member 1	Homo sapiens	101-106
24941669-6	2014	Dietary capsaicin reduces metabolic dysregulation in obese/diabetic mice by enhancing expression of adiponectin and its receptor.	Capsaicin	8-17	adiponectin, C1Q and collagen domain containing	Mus musculus	100-111
24941672-1	2014	Calcitonin gene-related peptide (CGRP), a 37 aminoacid-residue peptide, is a marker of afferent fibers in the upper gastrointestinal tract, being almost completely depleted following treatment with the selective neurotoxin capsaicin that targets these fibers via transient receptor potential vanilloid type-1 (TRPV-1).	Capsaicin	223-232	calcitonin related polypeptide alpha	Homo sapiens	0-31
24941672-1	2014	Calcitonin gene-related peptide (CGRP), a 37 aminoacid-residue peptide, is a marker of afferent fibers in the upper gastrointestinal tract, being almost completely depleted following treatment with the selective neurotoxin capsaicin that targets these fibers via transient receptor potential vanilloid type-1 (TRPV-1).	Capsaicin	223-232	calcitonin related polypeptide alpha	Homo sapiens	33-37
24013073-0	2013	Capsaicin pretreatment increased the bioavailability of cyclosporin in rats: involvement of P-glycoprotein and CYP 3A inhibition.	Capsaicin	0-9	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	92-106
25629137-4	2014	Capsaicin, a component of chili pepper and several other plants, is a highly selective ligand of TRPV1 receptors and has long been used in treatment of pain syndromes.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	97-102
24351908-6	2013	In the electrophysiological study, both polypeptides partially blocked the capsaicin-induced response of TRPV1, but only APHC3 inhibited acid-induced (pH 5.5) activation of the receptor.	Capsaicin	75-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-110
24211590-2	2013	Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and endogenous physical and chemical stimuli including heat and capsaicin.	Capsaicin	194-203	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
24211590-2	2013	Transient receptor potential vanilloid 1 (TRPV1) is a nonselective cation channel activated in response to a variety of exogenous and endogenous physical and chemical stimuli including heat and capsaicin.	Capsaicin	194-203	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
24529672-9	2013	mGluR5-mediated disinhibition can be initiated by glutamate transporter inhibitors, or indirectly by substance P, neurotensin, cholecystokinin, capsaicin, and AM404, the bioactive metabolite of acetaminophen in the brain.	Capsaicin	144-153	glutamate receptor, ionotropic, kainate 1	Mus musculus	0-6
24145133-8	2013	In contrast, capsaicin enhanced 4-AP induced epileptiform activity in vitro (1-100muM) and triggered bursting activity in vivo (100muM dialysis perfusion), which was abolished by the TRPV1 antagonist CZP.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	183-188
24174527-0	2013	Carboxyl-terminal domain of transient receptor potential vanilloid 1 contains distinct segments differentially involved in capsaicin- and heat-induced desensitization.	Capsaicin	123-132	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-68
24174527-1	2013	Multiple Ca(2+)-dependent processes are involved in capsaicin-induced desensitization of transient receptor potential vanilloid 1 (TRPV1), but desensitization of TRPV1 by heat occurs even in the absence of extracellular Ca(2+), although the mechanisms are unknown.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-129
24174527-1	2013	Multiple Ca(2+)-dependent processes are involved in capsaicin-induced desensitization of transient receptor potential vanilloid 1 (TRPV1), but desensitization of TRPV1 by heat occurs even in the absence of extracellular Ca(2+), although the mechanisms are unknown.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	131-136
24174527-2	2013	In this study, we tested the hypothesis that capsaicin and heat desensitize TRPV1 through distinct mechanisms involving distinct structural segments of TRPV1.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
24174527-2	2013	In this study, we tested the hypothesis that capsaicin and heat desensitize TRPV1 through distinct mechanisms involving distinct structural segments of TRPV1.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	152-157
24174527-8	2013	The results suggest that the activation and desensitization of TRPV1 by capsaicin and heat can be modulated differentially and disproportionally through different regions of TRPV1 CTD.	Capsaicin	72-81	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
24174527-8	2013	The results suggest that the activation and desensitization of TRPV1 by capsaicin and heat can be modulated differentially and disproportionally through different regions of TRPV1 CTD.	Capsaicin	72-81	transient receptor potential cation channel subfamily V member 1	Homo sapiens	174-179
24158445-1	2013	The regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channels by phosphoinositides is controversial.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-92
24158445-1	2013	The regulation of the heat- and capsaicin-activated transient receptor potential vanilloid 1 (TRPV1) channels by phosphoinositides is controversial.	Capsaicin	32-41	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-99
24158445-5	2013	When we incorporated TRPV1 into planar lipid bilayers consisting of neutral lipids, capsaicin-induced activity depended on phosphatidylinositol 4,5-bisphosphate.	Capsaicin	84-93	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-26
24036102-6	2013	Biotinylation assays in the presence of Kvbeta2 demonstrated increased cell surface expression levels of TRPV1, while patch-clamp experiments resulted in a significant increase of TRPV1 sensitivity to capsaicin.	Capsaicin	201-210	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	180-185
24102723-0	2013	Different TRPV1-mediated brain responses to intragastric infusion of capsaicin and capsiate.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	10-15
24102723-1	2013	Capsaicin and capsiate, which is an analogue of capsaicin, are agonists of capsaicin-binding transient potential vanilloid 1 (TRPV1) receptors.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	126-131
24102723-1	2013	Capsaicin and capsiate, which is an analogue of capsaicin, are agonists of capsaicin-binding transient potential vanilloid 1 (TRPV1) receptors.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	126-131
24102723-1	2013	Capsaicin and capsiate, which is an analogue of capsaicin, are agonists of capsaicin-binding transient potential vanilloid 1 (TRPV1) receptors.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	126-131
24102723-9	2013	These results demonstrate that TRPV1 is critical for the induction of activation in the hypothalamus by capsaicin and capsiate, and these distinct brain activations could help to explain the individual physiological reactions of capsaicin and capsiate.	Capsaicin	104-113	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
24102723-9	2013	These results demonstrate that TRPV1 is critical for the induction of activation in the hypothalamus by capsaicin and capsiate, and these distinct brain activations could help to explain the individual physiological reactions of capsaicin and capsiate.	Capsaicin	229-238	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	31-36
23896350-9	2013	CONCLUSIONS: Results indicate that the excitability of capsaicin sensitive C-fiber bladder afferent neurons is increased in association with reductions in transient A-type K+ current density and Kv1.4 alpha-subunit expression in injured rats.	Capsaicin	55-64	potassium voltage-gated channel subfamily A member 4	Rattus norvegicus	195-200
24188863-4	2013	Injected parenterally, capsaicin had no effect on von Frey fiber responses (tactile) but induced a transient hypothermia and hyperalgesia in both the tail flick (thermal) and grip force (musculoskeletal) assays, presumably by its agonistic action at TRPV1 sites.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	250-255
24142695-4	2013	Here we use a variety of cell biology and pharmacological approaches to show that PRL transiently enhanced capsaicin-evoked responses involve protein kinase C epsilon (PKCepsilon) or phosphatidylinositol 3-kinase (PI3K) pathways in female rat trigeminal (TG) neurons.	Capsaicin	107-116	protein kinase C, epsilon	Rattus norvegicus	142-166
24005536-0	2013	Capsaicin induces apoptosis in human osteosarcoma cells through AMPK-dependent and AMPK-independent signaling pathways.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	64-68
24005536-0	2013	Capsaicin induces apoptosis in human osteosarcoma cells through AMPK-dependent and AMPK-independent signaling pathways.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	83-87
24005536-3	2013	In the current study, we observed that capsaicin-induced growth inhibition and apoptosis in cultured osteosarcoma cells (U2OS and MG63), which were associated with a significant AMP-activated protein kinase (AMPK) activation.	Capsaicin	39-48	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	178-206
24005536-3	2013	In the current study, we observed that capsaicin-induced growth inhibition and apoptosis in cultured osteosarcoma cells (U2OS and MG63), which were associated with a significant AMP-activated protein kinase (AMPK) activation.	Capsaicin	39-48	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	208-212
24005536-4	2013	AMPK inhibition by compound C or RNA interference suppressed capsaicin-induced cytotoxicity, while AMPK activators (AICAR and A769662) promoted osteosarcoma cell death.	Capsaicin	61-70	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	0-4
24005536-5	2013	For the mechanism study, we found that AMPK activation was required for capsaicin-induced mTORC1 (mTOR complex 1) inhibition, B cell lymphoma 2 (Bcl-2) downregulation and Bax upregulation in MG63 cells.	Capsaicin	72-81	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	39-43
24005536-5	2013	For the mechanism study, we found that AMPK activation was required for capsaicin-induced mTORC1 (mTOR complex 1) inhibition, B cell lymphoma 2 (Bcl-2) downregulation and Bax upregulation in MG63 cells.	Capsaicin	72-81	CREB regulated transcription coactivator 1	Mus musculus	90-96
24005536-5	2013	For the mechanism study, we found that AMPK activation was required for capsaicin-induced mTORC1 (mTOR complex 1) inhibition, B cell lymphoma 2 (Bcl-2) downregulation and Bax upregulation in MG63 cells.	Capsaicin	72-81	BCL2 apoptosis regulator	Homo sapiens	126-143
24005536-5	2013	For the mechanism study, we found that AMPK activation was required for capsaicin-induced mTORC1 (mTOR complex 1) inhibition, B cell lymphoma 2 (Bcl-2) downregulation and Bax upregulation in MG63 cells.	Capsaicin	72-81	BCL2 apoptosis regulator	Homo sapiens	145-150
24005536-5	2013	For the mechanism study, we found that AMPK activation was required for capsaicin-induced mTORC1 (mTOR complex 1) inhibition, B cell lymphoma 2 (Bcl-2) downregulation and Bax upregulation in MG63 cells.	Capsaicin	72-81	BCL2 associated X, apoptosis regulator	Homo sapiens	171-174
24005536-6	2013	Capsaicin administration induced p53 activation, mitochondrial translocation and Bcl-2 killer association, such effects were dependent on AMPK activation.	Capsaicin	0-9	tumor protein p53	Homo sapiens	33-36
24005536-6	2013	Capsaicin administration induced p53 activation, mitochondrial translocation and Bcl-2 killer association, such effects were dependent on AMPK activation.	Capsaicin	0-9	BCL2 apoptosis regulator	Homo sapiens	81-86
24005536-6	2013	Capsaicin administration induced p53 activation, mitochondrial translocation and Bcl-2 killer association, such effects were dependent on AMPK activation.	Capsaicin	0-9	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	138-142
24005536-7	2013	Interestingly, we observed a significant pro-apoptotic c-Jun NH2-terminal kinases activation by capsaicin in MG63 cells, which appeared to be AMPK independent.	Capsaicin	96-105	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	142-146
24005536-9	2013	Molecular studies revealed that capsaicin activated AMPK-dependent and AMPK-independent signalings to mediate cell apoptosis.	Capsaicin	32-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	52-56
24005536-9	2013	Molecular studies revealed that capsaicin activated AMPK-dependent and AMPK-independent signalings to mediate cell apoptosis.	Capsaicin	32-41	protein kinase AMP-activated catalytic subunit alpha 1	Homo sapiens	71-75
24049058-9	2013	Capsaicin denervation attenuated the reduction of Ang-(1-7)-induced gastric lesions and the rise in GBF; these effects were restored by supplementation with calcitonin gene-related peptide (CGRP).	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	190-194
24142695-4	2013	Here we use a variety of cell biology and pharmacological approaches to show that PRL transiently enhanced capsaicin-evoked responses involve protein kinase C epsilon (PKCepsilon) or phosphatidylinositol 3-kinase (PI3K) pathways in female rat trigeminal (TG) neurons.	Capsaicin	107-116	protein kinase C, epsilon	Rattus norvegicus	168-178
24142695-6	2013	Results show that PRLR-S, but not PRLR-L, is capable of mediating PRL-induced transient enhancement of capsaicin responses in both male and female TG neurons.	Capsaicin	103-112	prolactin receptor	Rattus norvegicus	18-22
23722046-2	2013	Here, we first prepared nanovesicles containing rat pain sensory receptor, rat transient receptor potential vanilloid 1 (rTRPV1), which is activated by noxious heat and capsaicin.	Capsaicin	169-178	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	121-127
24260326-0	2013	The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.	Capsaicin	66-75	cofilin 1	Homo sapiens	92-99
24302912-0	2013	The pungent substances piperine, capsaicin, 6-gingerol and polygodial inhibit the human two-pore domain potassium channels TASK-1, TASK-3 and TRESK.	Capsaicin	33-42	potassium two pore domain channel subfamily K member 18	Homo sapiens	142-147
24302912-4	2013	We investigated whether the pungent substances piperine, capsaicin, 6-gingerol and polygodial have an effect on human K2P channels.	Capsaicin	57-66	keratin 76	Homo sapiens	118-121
24035514-2	2013	Among them, compound 24S showed stereospecific and excellent TRPV1 antagonism of capsaicin-induced activation.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
24260326-0	2013	The reversible increase in tight junction permeability induced by capsaicin is mediated via cofilin-actin cytoskeletal dynamics and decreased level of occludin.	Capsaicin	66-75	occludin	Homo sapiens	151-159
24260326-1	2013	Previous results demonstrated that capsaicin induces the reversible tight junctions (TJ) opening via cofilin activation.	Capsaicin	35-44	cofilin 1	Homo sapiens	101-108
24211679-2	2013	Understanding the actions of capsaicin led to the discovery of its receptor, transient receptor potential vanilloid subfamily member 1 (TRPV1).	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	136-141
24045094-7	2013	Capsaicin significantly elevated endogenous SP, by 29% in the mRNA and 17% in protein in the retina, with marked inhibition of the apoptosis and the activity of caspase-3 in the diabetic rats.	Capsaicin	0-9	caspase 3	Rattus norvegicus	161-170
24250792-10	2013	CONCLUSION AND IMPLICATIONS: Systemic capsaicin treatment of juvenile rats evokes anatomical and functional disappearance of the TRPV1-expressing neuronal cells but does not affect the TRPV1-expressing cells of the arterioles, implicating different effects of TRPV1 stimulation on the viability of these cell types.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	129-134
23942896-8	2013	Perfusion of the entire submandibular gland with the TRPV1 agonist capsaicin (1 muM) via the submandibular artery significantly increased CCh-induced salivation, whereas perfusion with TRPM8 and TRPA1 agonists (0.5 muM WS12 and 100 muM allyl isothiocyanate) decreased it.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-58
23992146-7	2013	Stimulation of primary afferent nerves with TNS (at 20 Hz) or capsaicin (100 nM) evoked a sustained venular dilatation that was attenuated by calcitonin gene-related peptide (CGRP) 8-37 (2 muM), a CGRP receptor antagonist.	Capsaicin	62-71	calcitonin-related polypeptide alpha	Rattus norvegicus	142-173
23992146-7	2013	Stimulation of primary afferent nerves with TNS (at 20 Hz) or capsaicin (100 nM) evoked a sustained venular dilatation that was attenuated by calcitonin gene-related peptide (CGRP) 8-37 (2 muM), a CGRP receptor antagonist.	Capsaicin	62-71	calcitonin-related polypeptide alpha	Rattus norvegicus	175-179
23992146-7	2013	Stimulation of primary afferent nerves with TNS (at 20 Hz) or capsaicin (100 nM) evoked a sustained venular dilatation that was attenuated by calcitonin gene-related peptide (CGRP) 8-37 (2 muM), a CGRP receptor antagonist.	Capsaicin	62-71	calcitonin-related polypeptide alpha	Rattus norvegicus	197-201
23580156-5	2013	We demonstrated that CPS induces pre- and early apoptotic cell surface exposure of calreticulin (CRT), HSP90, and HSP70 as well as ATP release.	Capsaicin	21-24	calreticulin	Homo sapiens	83-95
23580156-5	2013	We demonstrated that CPS induces pre- and early apoptotic cell surface exposure of calreticulin (CRT), HSP90, and HSP70 as well as ATP release.	Capsaicin	21-24	calreticulin	Homo sapiens	97-100
23580156-5	2013	We demonstrated that CPS induces pre- and early apoptotic cell surface exposure of calreticulin (CRT), HSP90, and HSP70 as well as ATP release.	Capsaicin	21-24	heat shock protein 90 alpha family class A member 1	Homo sapiens	103-108
23580156-5	2013	We demonstrated that CPS induces pre- and early apoptotic cell surface exposure of calreticulin (CRT), HSP90, and HSP70 as well as ATP release.	Capsaicin	21-24	heat shock protein family A (Hsp70) member 4	Homo sapiens	114-119
23942896-8	2013	Perfusion of the entire submandibular gland with the TRPV1 agonist capsaicin (1 muM) via the submandibular artery significantly increased CCh-induced salivation, whereas perfusion with TRPM8 and TRPA1 agonists (0.5 muM WS12 and 100 muM allyl isothiocyanate) decreased it.	Capsaicin	67-76	latexin	Homo sapiens	80-83
23942896-8	2013	Perfusion of the entire submandibular gland with the TRPV1 agonist capsaicin (1 muM) via the submandibular artery significantly increased CCh-induced salivation, whereas perfusion with TRPM8 and TRPA1 agonists (0.5 muM WS12 and 100 muM allyl isothiocyanate) decreased it.	Capsaicin	67-76	latexin	Homo sapiens	215-218
23942896-8	2013	Perfusion of the entire submandibular gland with the TRPV1 agonist capsaicin (1 muM) via the submandibular artery significantly increased CCh-induced salivation, whereas perfusion with TRPM8 and TRPA1 agonists (0.5 muM WS12 and 100 muM allyl isothiocyanate) decreased it.	Capsaicin	67-76	latexin	Homo sapiens	215-218
23929722-2	2013	Binding of capsaicin to the vanilloid receptor 1 (transient receptor potential cation channel subfamily V member 1 (TRPV1)) is one of the major cellular mechanisms responsible for these effects.	Capsaicin	11-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	28-114
23913765-5	2013	Results from our whole-cell patch-clamp recordings in isolated neurons showed that strong activation of CaSR with high concentrations of its agonists, including spermine, NPS R-568 and Ca(2+), inhibited the capsaicin-evoked whole-cell inward current.	Capsaicin	207-216	calcium-sensing receptor	Rattus norvegicus	104-108
23913765-6	2013	Blockade of CaSR with its antagonists NPS 2390 and NPS 2143 significantly enhanced the capsaicin-evoked TRPV1 current.	Capsaicin	87-96	calcium-sensing receptor	Rattus norvegicus	12-16
23913765-6	2013	Blockade of CaSR with its antagonists NPS 2390 and NPS 2143 significantly enhanced the capsaicin-evoked TRPV1 current.	Capsaicin	87-96	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	104-109
24051030-4	2013	Capsaicin (20mg/kg) was given to the animals to induce up-regulation of the CGRP.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
24051030-8	2013	The pre-treatment with capsaicin effectively up-regulated CGRP and its encoding mRNA and attenuated the cell apoptosis and caspase-3 activity in the retina.	Capsaicin	23-32	calcitonin-related polypeptide alpha	Rattus norvegicus	58-62
24051030-8	2013	The pre-treatment with capsaicin effectively up-regulated CGRP and its encoding mRNA and attenuated the cell apoptosis and caspase-3 activity in the retina.	Capsaicin	23-32	caspase 3	Rattus norvegicus	123-132
24051030-10	2013	Capsaicin may attenuate the apoptosis of the retina cells at early times of diabetes, via up-regulation of CGRP.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	107-111
24056223-1	2013	We recently demonstrated that pain-sensing neurons in the trigeminal system can be selectively anesthetized by co-application of QX-314 with the TRPV1 receptor agonist, capsaicin (QX cocktail).	Capsaicin	169-178	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	145-150
23929722-2	2013	Binding of capsaicin to the vanilloid receptor 1 (transient receptor potential cation channel subfamily V member 1 (TRPV1)) is one of the major cellular mechanisms responsible for these effects.	Capsaicin	11-20	transient receptor potential cation channel subfamily V member 1	Homo sapiens	116-121
23929722-3	2013	However, strong TRPV1 agonists like capsaicin elicit a sharp, burning pain that limits their dietary intake.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-21
23929722-7	2013	Co-incubation experiments of SH-SY5Y cells with the TRPV1 inhibitors trans-tert-butylcyclohexanol and capsazepine demonstrated that capsaicin, but not nonivamide, induces serotonin and dopamine release through TRPV1 activation.	Capsaicin	132-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	52-57
23929722-7	2013	Co-incubation experiments of SH-SY5Y cells with the TRPV1 inhibitors trans-tert-butylcyclohexanol and capsazepine demonstrated that capsaicin, but not nonivamide, induces serotonin and dopamine release through TRPV1 activation.	Capsaicin	132-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	210-215
23929722-8	2013	CONCLUSION: The results indicate a TRPV1-independent signaling pathway for nonivamide that might allow dietary administration of higher doses of nonivamide compared to capsaicin.	Capsaicin	168-177	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-40
24135942-8	2013	Of these four compounds, capsaicin and jaceosidin induced resistance against Pcc and Pst, which depended on both salicylic acid (SA) and jasmonic acid (JA) signaling, using Arabidopsis transgenic and mutant lines, including npr1 and NahG for SA signaling and jar1 for JA signaling.	Capsaicin	25-34	regulatory protein (NPR1)	Arabidopsis thaliana	224-228
23978788-6	2013	Nesfatin-1-induced protection was attenuated by suppression of COX-1 and COX-2 activity, the inhibition of NOS with L-NNA, the deactivation of afferent nerves with neurotoxic doses of capsaicin, and the pretreatment with capsazepine to inhibit vanilloid VR1 receptors.	Capsaicin	184-193	nucleobindin 2	Rattus norvegicus	0-10
24012930-5	2013	Capsaicin also activates the mitochondrial caspase 3-dependent death cascade.	Capsaicin	0-9	caspase 3	Homo sapiens	43-52
24147119-1	2013	The transient receptor potential vanilloid receptor 1 (TRPV1) channel is a nonselective cation channel activated by a variety of exogenous and endogenous physical and chemical stimuli, such as temperature (&gt;=42  C), capsaicin, a pungent compound in hot chili peppers, and allyl isothiocyanate.	Capsaicin	219-228	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-60
23719767-6	2013	METHODS: To evaluate the mechanism of the antinociceptive effects of KMS4034, capsaicin (I(CAP))- and heat (I(heat))-induced currents in TRPV1 expressing HEK293 cells were observed after the application of KMS4034.	Capsaicin	78-87	transient receptor potential cation channel subfamily V member 1	Homo sapiens	137-142
23842678-0	2013	Hydrogen sulfide induces hypersensitivity of rat capsaicin-sensitive lung vagal neurons: role of TRPA1 receptors.	Capsaicin	49-58	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	97-102
24004146-5	2013	We then developed a setup for rapid and quantitative delivery to multiple subcellular areas, delivering the molecule capsaicin to stimulate opening of Transient Receptor Potential Vanilloid subfamily member 1 (TRPV1) channels, membrane receptors involved in pain sensation.	Capsaicin	117-126	transient receptor potential cation channel subfamily V member 1	Homo sapiens	210-215
24304576-8	2013	Destruction of sensory afferent fibres with capsaicin or blocking of vanilloid receptors with capsazepine resulted in a significant reduction of ghrelin, OX-A and nesfatin-1-induced acceleration of ulcer healing.	Capsaicin	44-53	nucleobindin 2	Homo sapiens	163-173
23733747-3	2013	In this study, we used the transient receptor potential vanilloid receptor (TRPV1) receptor agonist, capsaicin, as an intranasal challenge while comparing the changes in blood flow with optical rhinometry between subjects with NAIR and healthy controls (HCs).	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
23500195-4	2013	TRPV1 desensitization by topical agonists (e.g. high concentration capsaicin creams and patches) has been in clinical use for decades to alleviate chronic painful conditions like diabetic neuropathy.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
23747734-3	2013	Intraperitoneal administration of CAP (10mg/kg body weight) to Swiss albino mice suppressed the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3.	Capsaicin	34-37	transformation related protein 53, pseudogene	Mus musculus	186-189
23747734-3	2013	Intraperitoneal administration of CAP (10mg/kg body weight) to Swiss albino mice suppressed the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3.	Capsaicin	34-37	B cell leukemia/lymphoma 2	Mus musculus	191-196
23747734-3	2013	Intraperitoneal administration of CAP (10mg/kg body weight) to Swiss albino mice suppressed the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3.	Capsaicin	34-37	BCL2-associated X protein	Mus musculus	198-201
23747734-3	2013	Intraperitoneal administration of CAP (10mg/kg body weight) to Swiss albino mice suppressed the development of lung carcinoma by amending the protein expressions of apoptotic regulators p53, Bcl-2, Bax and caspase-3.	Capsaicin	34-37	caspase 3	Mus musculus	206-215
23524012-6	2013	There is also some evidence that as a result of inflammation in the airways, Adelta fibres can begin to express neuropeptides and TRPV1 receptors so that they can become responsive to endogenous activators of this ion channel and to irritants like capsaicin.	Capsaicin	248-257	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-135
23916509-10	2013	In Ca(2+) imaging experiments, capsaicin, a TRPV1 agonist, induced a significant increase in intracellular calcium ion concentration ([Ca(2+)]i) in rat primary cultured VG neurons, which was almost completely blocked by capsazepine, a TRPV1-specific antagonist.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	44-49
23916509-10	2013	In Ca(2+) imaging experiments, capsaicin, a TRPV1 agonist, induced a significant increase in intracellular calcium ion concentration ([Ca(2+)]i) in rat primary cultured VG neurons, which was almost completely blocked by capsazepine, a TRPV1-specific antagonist.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	235-240
23838383-9	2013	RESULTS: Capsaicin pretreatment in the CIR group resulted in increased lung wet-to-dry ratio, neutrophil counts in bronchoalveolar lavage fluids, and lung pathologic lesions, along with higher levels of plasma tumor necrosis factor alpha and interleukin 8 and lower level of interleukin 10 (P &lt; 0.05 versus IR), although capsaicin did not alter the above variables in the CS group (P &gt; 0.05 versus S).	Capsaicin	9-18	tumor necrosis factor	Oryctolagus cuniculus	210-237
23838383-9	2013	RESULTS: Capsaicin pretreatment in the CIR group resulted in increased lung wet-to-dry ratio, neutrophil counts in bronchoalveolar lavage fluids, and lung pathologic lesions, along with higher levels of plasma tumor necrosis factor alpha and interleukin 8 and lower level of interleukin 10 (P &lt; 0.05 versus IR), although capsaicin did not alter the above variables in the CS group (P &gt; 0.05 versus S).	Capsaicin	9-18	interleukin-8	Oryctolagus cuniculus	242-289
23811042-3	2013	Many nociceptors express transient receptor potential V1 (TRPV1) channels, and in a preceding study most dissociated DRG neurons exhibiting SA were excited by the TRPV1 activator, capsaicin.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-56
23811042-3	2013	Many nociceptors express transient receptor potential V1 (TRPV1) channels, and in a preceding study most dissociated DRG neurons exhibiting SA were excited by the TRPV1 activator, capsaicin.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
23811042-3	2013	Many nociceptors express transient receptor potential V1 (TRPV1) channels, and in a preceding study most dissociated DRG neurons exhibiting SA were excited by the TRPV1 activator, capsaicin.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	163-168
23811042-7	2013	Similar reversal of behavioral hypersensitivity was induced by intrathecal oligodeoxynucleotides antisense to TRPV1, which knocked down TRPV1 protein and reduced capsaicin-evoked currents.	Capsaicin	162-171	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
23774632-8	2013	The transient receptor potential vanilloid subfamily member 1 (TRPV1), the capsaicin receptor, is implicated in inflammatory hyperalgesia, and we demonstrated that topical capsaicin application causes short-lasting mechanical hyperalgesia in the face.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	63-68
23774632-10	2013	Moreover, capsaicin induced the cellular demise of primary TRPV1-positive trigeminal ganglion neurons in a dose-dependent manner, and this effect was inhibited by a free radical scavenger and a pancaspase inhibitor.	Capsaicin	10-19	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	59-64
23858010-4	2013	Laryngeal citric acid-evoked swallowing was mimicked by laryngeal capsaicin challenges, implicating transient receptor potential vanilloid 1 (TRPV1)-expressing laryngeal afferent nerves arising from the jugular ganglia.	Capsaicin	66-75	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	100-140
23858010-4	2013	Laryngeal citric acid-evoked swallowing was mimicked by laryngeal capsaicin challenges, implicating transient receptor potential vanilloid 1 (TRPV1)-expressing laryngeal afferent nerves arising from the jugular ganglia.	Capsaicin	66-75	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	142-147
23850608-5	2013	TRPV1-mediated currents were measured in acutely isolated primary sensory neurons with the whole-cell patch clamp technique using capsaicin (100 nM) as the agonist.	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
23958300-0	2013	Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway.	Capsaicin	0-9	mitogen-activated protein kinase 14	Mus musculus	101-104
23958300-4	2013	Additional results showed that p38 mitogen-activated protein kinase (MAPK) is also involved in capsaicin-induced glucose transport downstream of AMPK because capsaicin increased p38 MAPK phosphorylation significantly and its specific inhibitor SB203580 inhibited capsaicin-mediated glucose uptake.	Capsaicin	95-104	mitogen-activated protein kinase 14	Mus musculus	31-34
23850608-7	2013	NGF sensitized TRPV1 in 31.0% of cells (13 of 42), with a mean (+-SE) increase in the capsaicin-induced current of 262 +- 47% over the baseline current.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
23958300-4	2013	Additional results showed that p38 mitogen-activated protein kinase (MAPK) is also involved in capsaicin-induced glucose transport downstream of AMPK because capsaicin increased p38 MAPK phosphorylation significantly and its specific inhibitor SB203580 inhibited capsaicin-mediated glucose uptake.	Capsaicin	95-104	mitogen-activated protein kinase 14	Mus musculus	178-186
24044034-2	2013	The aims of this study were to investigate 1) if cutaneous sensitization by topical application of capsaicin (TRPV1 receptor agonist) can facilitate the size, duration and spatial extent of this vasomotor response and 2) if males and females respond differently.	Capsaicin	99-108	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
23958300-4	2013	Additional results showed that p38 mitogen-activated protein kinase (MAPK) is also involved in capsaicin-induced glucose transport downstream of AMPK because capsaicin increased p38 MAPK phosphorylation significantly and its specific inhibitor SB203580 inhibited capsaicin-mediated glucose uptake.	Capsaicin	158-167	mitogen-activated protein kinase 14	Mus musculus	31-34
23958300-4	2013	Additional results showed that p38 mitogen-activated protein kinase (MAPK) is also involved in capsaicin-induced glucose transport downstream of AMPK because capsaicin increased p38 MAPK phosphorylation significantly and its specific inhibitor SB203580 inhibited capsaicin-mediated glucose uptake.	Capsaicin	158-167	mitogen-activated protein kinase 14	Mus musculus	178-186
23958300-4	2013	Additional results showed that p38 mitogen-activated protein kinase (MAPK) is also involved in capsaicin-induced glucose transport downstream of AMPK because capsaicin increased p38 MAPK phosphorylation significantly and its specific inhibitor SB203580 inhibited capsaicin-mediated glucose uptake.	Capsaicin	158-167	mitogen-activated protein kinase 14	Mus musculus	31-34
23958300-4	2013	Additional results showed that p38 mitogen-activated protein kinase (MAPK) is also involved in capsaicin-induced glucose transport downstream of AMPK because capsaicin increased p38 MAPK phosphorylation significantly and its specific inhibitor SB203580 inhibited capsaicin-mediated glucose uptake.	Capsaicin	158-167	mitogen-activated protein kinase 14	Mus musculus	178-186
23958300-6	2013	Capsaicin stimulated ROS generation in C2C12 muscle cells, and when ROS were captured using the nonspecific antioxidant NAC, the increase in both capsaicin-induced AMPK phosphorylation and capsaicin-induced glucose uptake was attenuated, suggesting that ROS function as an upstream activator of AMPK.	Capsaicin	146-155	NLR family, pyrin domain containing 1A	Mus musculus	120-123
23958300-6	2013	Capsaicin stimulated ROS generation in C2C12 muscle cells, and when ROS were captured using the nonspecific antioxidant NAC, the increase in both capsaicin-induced AMPK phosphorylation and capsaicin-induced glucose uptake was attenuated, suggesting that ROS function as an upstream activator of AMPK.	Capsaicin	189-198	NLR family, pyrin domain containing 1A	Mus musculus	120-123
23958300-7	2013	Taken together, these results suggest that capsaicin, independent of insulin, increases glucose uptake via ROS generation and consequent AMPK and p38 MAPK activations.	Capsaicin	43-52	mitogen-activated protein kinase 14	Mus musculus	146-149
23938388-7	2013	Oral capsaicin exposure significantly increased c-Fos expression not only in the nucleus tractus of solitarius but also in the paraventricular nucleus.	Capsaicin	5-14	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	48-53
23916247-5	2013	This review will summarize the current knowledge on regulation of TRP channels by PLC, with special focus on TRPC-s, which can be considered as effectors of PLC and the heat- and capsaicin-sensitive TRPV1, which is modulated by the PLC pathway in a complex manner.	Capsaicin	179-188	transient receptor potential cation channel subfamily V member 1	Homo sapiens	199-204
23919305-13	2013	After treatment with TRPV1 agonist capsaicin (CAP), [Ca(2+)]i was further increased, whereas [Ca(2+)]i was decreased after administration of TRPV1 antagonist capsazepine (CPZ) in ASMC of the asthmatic group.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	21-26
23919305-13	2013	After treatment with TRPV1 agonist capsaicin (CAP), [Ca(2+)]i was further increased, whereas [Ca(2+)]i was decreased after administration of TRPV1 antagonist capsazepine (CPZ) in ASMC of the asthmatic group.	Capsaicin	46-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	21-26
23962823-0	2013	Activation of extracellular signal-regulated kinase in the trigeminal ganglion following both treatment of the dura mater with capsaicin and cortical spreading depression.	Capsaicin	127-136	mitogen-activated protein kinase 1	Homo sapiens	14-51
23962823-4	2013	Western blot and immunohistochemical analyses showed a significant increase in the ERK phosphorylation levels 3 min following an application of 10mM capsaicin to the dura mater.	Capsaicin	149-158	mitogen-activated protein kinase 1	Homo sapiens	83-86
23349076-1	2013	BACKGROUND: Previous studies have identified neuromedin U receptor 2 (NMUR2) as the subtype mediating the effects of neuromedin U on acute chemo-nociception induced by capsaicin or formalin injection.	Capsaicin	168-177	neuromedin U receptor 2	Mus musculus	45-68
23349076-1	2013	BACKGROUND: Previous studies have identified neuromedin U receptor 2 (NMUR2) as the subtype mediating the effects of neuromedin U on acute chemo-nociception induced by capsaicin or formalin injection.	Capsaicin	168-177	neuromedin U receptor 2	Mus musculus	70-75
23349076-1	2013	BACKGROUND: Previous studies have identified neuromedin U receptor 2 (NMUR2) as the subtype mediating the effects of neuromedin U on acute chemo-nociception induced by capsaicin or formalin injection.	Capsaicin	168-177	neuromedin U	Mus musculus	45-57
22722616-6	2013	CONCLUSION: Stimulation of TRPV1 by capsaicinoids strongly improved safety and efficacy of swallow and shortened the swallow response in older patients with OD.	Capsaicin	36-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
28664062-7	2013	2-APB dose-dependently potentiated rTRPV1 currents, that activated by capsaicin, protons, or noxious heat.	Capsaicin	70-79	arginyl aminopeptidase	Rattus norvegicus	2-5
28664062-7	2013	2-APB dose-dependently potentiated rTRPV1 currents, that activated by capsaicin, protons, or noxious heat.	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-41
28664062-8	2013	2-APB potentiated the capsaicin-activated rTRPV1 current from both side of the patch membrane.	Capsaicin	22-31	arginyl aminopeptidase	Rattus norvegicus	2-5
28664062-8	2013	2-APB potentiated the capsaicin-activated rTRPV1 current from both side of the patch membrane.	Capsaicin	22-31	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-48
28664062-9	2013	A structural analogue of 2-APB, diphenylboronic anhydride, showed the same potentiation effect on the capsaicin-activated rTRPV1 current.	Capsaicin	102-111	arginyl aminopeptidase	Rattus norvegicus	27-30
28664062-9	2013	A structural analogue of 2-APB, diphenylboronic anhydride, showed the same potentiation effect on the capsaicin-activated rTRPV1 current.	Capsaicin	102-111	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	122-128
23757176-4	2013	Here we show that, surprisingly, AITC-induced activation of TRPV1 does not require interaction with cysteine residues, but is largely dependent on S513, a residue that is involved in capsaicin binding.	Capsaicin	183-192	transient receptor potential cation channel subfamily V member 1	Homo sapiens	60-65
23605066-5	2013	Chronic dietary capsaicin promoted lipolysis by increasing hepatic phosphorylated hormone-sensitive lipase (phospho-HSL), carnitine palmitoyltransferase 1 (CPT1), and peroxisome proliferator-activated receptor delta (PPARdelta) in wild-type (WT) mice.	Capsaicin	16-25	carnitine palmitoyltransferase 1a, liver	Mus musculus	122-154
23605066-0	2013	Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor delta activation.	Capsaicin	8-17	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	68-108
23605066-5	2013	Chronic dietary capsaicin promoted lipolysis by increasing hepatic phosphorylated hormone-sensitive lipase (phospho-HSL), carnitine palmitoyltransferase 1 (CPT1), and peroxisome proliferator-activated receptor delta (PPARdelta) in wild-type (WT) mice.	Capsaicin	16-25	carnitine palmitoyltransferase 1a, liver	Mus musculus	156-160
23605066-0	2013	Dietary capsaicin prevents nonalcoholic fatty liver disease through transient receptor potential vanilloid 1-mediated peroxisome proliferator-activated receptor delta activation.	Capsaicin	8-17	peroxisome proliferator activator receptor delta	Mus musculus	118-166
23605066-3	2013	Here, we report beneficial effects of chronic dietary capsaicin intake on NAFLD which is mediated by the transient receptor potential vanilloid 1 (TRPV1) activation.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	105-145
23605066-5	2013	Chronic dietary capsaicin promoted lipolysis by increasing hepatic phosphorylated hormone-sensitive lipase (phospho-HSL), carnitine palmitoyltransferase 1 (CPT1), and peroxisome proliferator-activated receptor delta (PPARdelta) in wild-type (WT) mice.	Capsaicin	16-25	peroxisome proliferator activator receptor delta	Mus musculus	167-215
23605066-3	2013	Here, we report beneficial effects of chronic dietary capsaicin intake on NAFLD which is mediated by the transient receptor potential vanilloid 1 (TRPV1) activation.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	147-152
23605066-4	2013	The results showed that TRPV1 activation by capsaicin reduced free fatty acids (FFAs) induced the intracellular lipid droplets in HepG2 cells and prevented fatty liver in vivo.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
23605066-5	2013	Chronic dietary capsaicin promoted lipolysis by increasing hepatic phosphorylated hormone-sensitive lipase (phospho-HSL), carnitine palmitoyltransferase 1 (CPT1), and peroxisome proliferator-activated receptor delta (PPARdelta) in wild-type (WT) mice.	Capsaicin	16-25	peroxisome proliferator activator receptor delta	Mus musculus	217-226
23605066-5	2013	Chronic dietary capsaicin promoted lipolysis by increasing hepatic phosphorylated hormone-sensitive lipase (phospho-HSL), carnitine palmitoyltransferase 1 (CPT1), and peroxisome proliferator-activated receptor delta (PPARdelta) in wild-type (WT) mice.	Capsaicin	16-25	lipase, hormone sensitive	Mus musculus	116-119
23605066-9	2013	In the in vivo study, TRPV1 activation by dietary capsaicin enhanced hepatic PPARdelta and autophagy-related proteins and reduced hepatic enzymes and inflammatory factor in WT but not TRPV1(-/-) mice.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	22-27
23605066-9	2013	In the in vivo study, TRPV1 activation by dietary capsaicin enhanced hepatic PPARdelta and autophagy-related proteins and reduced hepatic enzymes and inflammatory factor in WT but not TRPV1(-/-) mice.	Capsaicin	50-59	peroxisome proliferator activator receptor delta	Mus musculus	77-86
23932918-7	2013	Similarly, UA at 2 mg/kg produced significant antinociception in the intracolonic administration of 0.3% capsaicin (a TRPV1 agonist) in mice.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	118-123
23605066-10	2013	TRPV1 activation by dietary capsaicin prevents NAFLD through PPARdelta-dependent autophagy enhancement in mice.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
23932918-8	2013	It has been reported the inhibition produced by UA on the calcium-flux induced by capsaicin on TRPV1 receptor suggesting the antagonistic activity of this receptor.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
23605066-10	2013	TRPV1 activation by dietary capsaicin prevents NAFLD through PPARdelta-dependent autophagy enhancement in mice.	Capsaicin	28-37	peroxisome proliferator activator receptor delta	Mus musculus	61-70
23436436-6	2013	Subsets of the traced S4 afferent collaterals expressed transient receptor potential vanilloid 1 (TRPV1), which transduces a nociceptive response to capsaicin.	Capsaicin	149-158	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	56-96
23436436-6	2013	Subsets of the traced S4 afferent collaterals expressed transient receptor potential vanilloid 1 (TRPV1), which transduces a nociceptive response to capsaicin.	Capsaicin	149-158	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	98-103
23911956-2	2013	Thus, we investigated the abdominal nociception caused by peritoneal stimulation with TRPV1 (capsaicin) and TRPA1 (allyl isothiocyanate, AITC) agonists and their mechanisms in rats.	Capsaicin	93-102	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	86-91
23911956-4	2013	injection of either capsaicin or AITC (0.03-10 mg/kg) induced short-term (up to 20 min) and dose-dependent abdominal nociception, and also produced c-fos expression in spinal afferents of the dorsal horn.	Capsaicin	20-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	148-153
23911956-5	2013	TRPV1 antagonism prevented (94 +- 4% inhibition) nociception induced by capsaicin but not by AITC.	Capsaicin	72-81	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
23911956-7	2013	Moreover, nociception induced by either capsaicin or AITC was reduced by the desensitisation of TRPV1-positive sensory fibres with resiniferatoxin (73 +- 18 and 76 +- 15% inhibitions, respectively) and by the NK1 receptor antagonist aprepitant (56 +- 5 and 53 +- 8% inhibitions, respectively).	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	96-101
23911956-7	2013	Moreover, nociception induced by either capsaicin or AITC was reduced by the desensitisation of TRPV1-positive sensory fibres with resiniferatoxin (73 +- 18 and 76 +- 15% inhibitions, respectively) and by the NK1 receptor antagonist aprepitant (56 +- 5 and 53 +- 8% inhibitions, respectively).	Capsaicin	40-49	tachykinin receptor 1	Rattus norvegicus	209-221
23255326-5	2013	Treatment with the AT2 R antagonist EMA401 resulted in dose-related functional inhibition of capsaicin responses (IC50  = 10 nmol/L), which was reversed by 8-bromo-cAMP, and reduced neurite length and density; AngII treatment significantly enhanced capsaicin responses, cAMP levels and neurite outgrowth.	Capsaicin	249-258	angiotensin II receptor type 2	Homo sapiens	19-24
23707246-7	2013	These results suggest that the anxiogenic-like effect produced by capsaicin is primarily due to TRPV1 activation within the dPAG in mice, but that dPAG TRPV1 receptors do not exert a tonic control over defensive behavior in mice exposed to the EPM.	Capsaicin	66-75	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	96-101
23796768-0	2013	Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	142-182
23796768-0	2013	Design and synthesis of conformationally restricted capsaicin analogues based in the 1, 3, 4-thiadiazole heterocycle reveal a novel family of transient receptor potential vanilloid 1 (TRPV1) antagonists.	Capsaicin	52-61	transient receptor potential cation channel subfamily V member 1	Homo sapiens	184-189
23255326-0	2013	Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons.	Capsaicin	90-99	angiotensin II receptor type 2	Homo sapiens	0-30
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-101
23255326-0	2013	Angiotensin II type 2 receptor (AT2 R) localization and antagonist-mediated inhibition of capsaicin responses and neurite outgrowth in human and rat sensory neurons.	Capsaicin	90-99	angiotensin II receptor type 2	Homo sapiens	32-37
23255326-5	2013	Treatment with the AT2 R antagonist EMA401 resulted in dose-related functional inhibition of capsaicin responses (IC50  = 10 nmol/L), which was reversed by 8-bromo-cAMP, and reduced neurite length and density; AngII treatment significantly enhanced capsaicin responses, cAMP levels and neurite outgrowth.	Capsaicin	93-102	angiotensin II receptor type 2	Homo sapiens	19-24
23657286-3	2013	We examined the effect of the vanilloid compound zingerone, which activates TRPV1 channels in the cell body of a primary afferent neuron, on glutamatergic excitatory transmission in the SG neurons of adult rat spinal cord slices by using the whole cell patch-clamp technique.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	76-81
23454157-3	2013	RESULTS: On phenylephrine contracted preparations electrical field stimulation and the H2S donor GYY4137 evoked frequency and concentration dependent relaxation, which was reduced by desensitizing capsaicin sensitive primary afferents with capsaicin, and the blockade of adenosine 5"-triphosphate dependent K(+) channels, cyclooxygenase and cyclooxygenase-1 with glibenclamide, indomethacin and SC560, respectively.	Capsaicin	197-206	prostaglandin-endoperoxide synthase 1	Homo sapiens	341-357
23454157-9	2013	H2S also promotes the release of sensory neuropeptides and cyclooxygenase-1 pathway derived prostanoids from capsaicin sensitive primary afferents via transient receptor potential A1, transient receptor potential vanilloid 1 and/or related ion channel activation.	Capsaicin	109-118	prostaglandin-endoperoxide synthase 1	Sus scrofa	59-75
23701723-5	2013	Similarly, in humans, COMT functional haplotypes were associated with thermal pain perception and with capsaicin-induced pain.	Capsaicin	103-112	catechol-O-methyltransferase	Homo sapiens	22-26
23701723-7	2013	The ancestral Comt variant, without a B2 SINE insertion, was more strongly associated with sensitivity to capsaicin in female vs male mice.	Capsaicin	106-115	catechol-O-methyltransferase	Mus musculus	14-18
23701723-8	2013	In humans, the haplotype coding for low COMT activity increased capsaicin-induced pain perception in women, but not men.	Capsaicin	64-73	catechol-O-methyltransferase	Homo sapiens	40-44
23411401-10	2013	Phospholipase C (PLC) was previously shown to be involved in capsaicin-induced OPG expression.	Capsaicin	61-70	TNF receptor superfamily member 11b	Homo sapiens	79-82
23480366-8	2013	L-NNA and capsaicin that augmented LI and decreased EBF, also significantly reduced melatonin-induced protection and hyperemia; both were restored with L-arginine and calcitonin gene-related peptide (CGRP) added to melatonin.	Capsaicin	10-19	calcitonin-related polypeptide alpha	Rattus norvegicus	167-198
23480366-8	2013	L-NNA and capsaicin that augmented LI and decreased EBF, also significantly reduced melatonin-induced protection and hyperemia; both were restored with L-arginine and calcitonin gene-related peptide (CGRP) added to melatonin.	Capsaicin	10-19	calcitonin-related polypeptide alpha	Rattus norvegicus	200-204
23843517-3	2013	Conversely, chronic pharmacological activation of TRPV1 by capsaicin leads to calcium influx-induced adaptation of the channel.	Capsaicin	59-68	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	50-55
23843517-9	2013	Capsaicin-induced desensitization of TRPV1 currents was significantly reduced, whereas capsaicin-induced nerve impulses in the skin-nerve preparation increased in mice lacking this isoform.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	37-42
23545271-10	2013	TRPV1 channels are activated by various agents including capsaicin (CAP), the pungent component of hot chili peppers, and are blocked by capsazepine.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
23545271-11	2013	An oxidative environment also increased CAP-evoked TRPV1 currents in the neurons.	Capsaicin	40-43	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	51-56
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	transient receptor potential cation channel subfamily V member 1	Homo sapiens	103-108
22982061-2	2013	Prolonged activation of TRPV1 by capsaicin leads to cell swelling and formation of membrane blebs in rat dorsal root ganglion (DRG) neurons.	Capsaicin	33-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	TNF receptor superfamily member 11b	Homo sapiens	192-207
22982061-13	2013	Cells co-expressing TRPV1 and calretinin were less sensitive to TRPV1-mediated, capsaicin-induced volume increases.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-25
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	TNF receptor superfamily member 11b	Homo sapiens	209-212
22982061-13	2013	Cells co-expressing TRPV1 and calretinin were less sensitive to TRPV1-mediated, capsaicin-induced volume increases.	Capsaicin	80-89	calbindin 2	Mus musculus	30-40
22982061-13	2013	Cells co-expressing TRPV1 and calretinin were less sensitive to TRPV1-mediated, capsaicin-induced volume increases.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	64-69
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	TNF superfamily member 11	Homo sapiens	214-265
22982061-14	2013	In TRPV1-expressing NIH3T3 cells, calretinin decreased the capsaicin-induced Ca(2+) and Na(+) influx.	Capsaicin	59-68	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	3-8
23411401-1	2013	OBJECTIVE: We previously demonstrated that the activation of transient receptor potential vanilloid 1 (TRPV1), a nociceptive ion channel receptor, by capsaicin led to the up-regulation of the osteoprotegerin (OPG)/receptor activator of nuclear factor kappa B ligand (RANKL) ratio in human periodontal ligament (HPDL) cells.	Capsaicin	150-159	TNF superfamily member 11	Homo sapiens	267-272
22982061-14	2013	In TRPV1-expressing NIH3T3 cells, calretinin decreased the capsaicin-induced Ca(2+) and Na(+) influx.	Capsaicin	59-68	calbindin 2	Mus musculus	34-44
23603259-3	2013	We show that monoclonal antibodies with high affinity to ARTN, completely inhibit ARTN-induced Ret and ERK activation in a human neuroblastoma cell line, and block capsaicin-induced CGRP secretion from primary rat DRG cultures.	Capsaicin	164-173	artemin	Homo sapiens	57-61
23636721-7	2013	The TRPV1 receptor antagonist A-425619 abolished capsaicin-triggered currents and raised the threshold of heat-activated currents.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
23685721-5	2013	However, silencing TRPV1(+) or TRPA1(+) neurons allowed allyl isothiocyanate or capsaicin, respectively, to evoke itch, implying that certain peripheral afferents may normally indirectly inhibit algogens from eliciting itch.	Capsaicin	80-89	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
23685721-5	2013	However, silencing TRPV1(+) or TRPA1(+) neurons allowed allyl isothiocyanate or capsaicin, respectively, to evoke itch, implying that certain peripheral afferents may normally indirectly inhibit algogens from eliciting itch.	Capsaicin	80-89	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	31-36
23742617-6	2013	Furthermore, treatment with 1 also inhibited pain-like behavior induced by phenyl-p-benzoquinone, complete Freund"s adjuvant (CFA), capsaicin (an agonist of transient receptor potential vanilloid 1, TRPV1), and both phases of the formalin test.	Capsaicin	132-141	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	199-204
23603259-3	2013	We show that monoclonal antibodies with high affinity to ARTN, completely inhibit ARTN-induced Ret and ERK activation in a human neuroblastoma cell line, and block capsaicin-induced CGRP secretion from primary rat DRG cultures.	Capsaicin	164-173	calcitonin related polypeptide alpha	Homo sapiens	182-186
23499803-0	2013	Different responses of galanin and calcitonin gene-related peptide to capsaicin stimulation on dorsal root ganglion neurons in vitro.	Capsaicin	70-79	galanin and GMAP prepropeptide	Homo sapiens	23-30
23499803-0	2013	Different responses of galanin and calcitonin gene-related peptide to capsaicin stimulation on dorsal root ganglion neurons in vitro.	Capsaicin	70-79	calcitonin related polypeptide alpha	Homo sapiens	35-66
23421411-1	2013	INTRODUCTION: The selective excitatory action of capsaicin followed by long-term chemoanalgesia due to an action on the "capsaicin receptor" of C-polymodal nociceptors, cloned 15 years ago, opened up fascinating perspectives for a class of nociceptor blocking analgesics.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	121-139
23551064-1	2013	BACKGROUND: Reversible defunctionalisation of nociceptors by the TRPV1 agonist capsaicin in high concentration is an emerging new concept for the treatment of peripheral neuropathic pain.	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	65-70
23384628-0	2013	Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats.	Capsaicin	86-95	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	8-13
23264449-1	2013	TRPV1 was originally characterized as an integrator of various noxious stimuli such as capsaicin, heat, and protons.	Capsaicin	87-96	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
23603336-7	2013	Furthermore, the inhibitory effect of capsaicin was also shown in primary cultured cells from TRPV1(-/-) mice.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	94-99
23859514-4	2013	Patch and cream containing capsaicin, the most famous TRPV1 agonist, are commercialized to relieve neuropathic pain.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	54-59
23384628-12	2013	CONCLUSIONS: The reflex apnea evoked by laryngeal CS requires activation of both TRPA1 and TRPV1 receptors, which are likely to be located at the terminals of superior laryngeal capsaicin-sensitive afferents.	Capsaicin	178-187	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	81-86
23384628-12	2013	CONCLUSIONS: The reflex apnea evoked by laryngeal CS requires activation of both TRPA1 and TRPV1 receptors, which are likely to be located at the terminals of superior laryngeal capsaicin-sensitive afferents.	Capsaicin	178-187	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
23172292-9	2013	Additionally, we show that, after a noxious stimulus (intradermal capsaicin injection), these NK-1r on pyramidal neurons were internalized, providing evidence that these neurons become responsive to peripheral noxious stimulation.	Capsaicin	66-75	tachykinin receptor 1	Rattus norvegicus	94-99
23578956-6	2013	Moreover, similar to wild-type littermates, Nf1+- mice developed inflammation-induced heat and mechanical hypersensitivity, capsaicin-induced nocifensive behavior, histamine-dependent or -independent scratching, and chronic constriction injury-induced cold allodynia.	Capsaicin	124-133	neurofibromin 1	Mus musculus	44-47
23384628-0	2013	Role of TRPA1 and TRPV1 in the ROS-dependent sensory irritation of superior laryngeal capsaicin-sensitive afferents by cigarette smoke in anesthetized rats.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	18-23
23384628-2	2013	The TRPA1 and TRPV1 receptors are two types of Ca(2+)-permeant channels located at the terminals of airway capsaicin-sensitive afferents.	Capsaicin	107-116	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	4-9
23384628-2	2013	The TRPA1 and TRPV1 receptors are two types of Ca(2+)-permeant channels located at the terminals of airway capsaicin-sensitive afferents.	Capsaicin	107-116	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
23523715-2	2013	Concentration-response curves for angiotensin II and blood flow were obtained in contralateral carotid from non-treated or capsaicin-treated streptozotocin-induced diabetic rats that underwent carotid balloon injury.	Capsaicin	123-132	angiotensinogen	Rattus norvegicus	34-48
23471827-6	2013	Western blot and real-time PCR analyses revealed that capsaicinoids significantly enhanced the expressions of hepatic cholesterol 7alpha-hydroxylase and transient receptor potential vanilloid type-1 but did not affect the expression of 3-hydroxy-3-methylglutaryl-CoA reductase in the OVX rats.	Capsaicin	54-67	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	118-148
23471827-8	2013	The hypocholesterolemic activity of capsaicinoids is caused by the stimulating conversion of cholesterol to bile acids by upregulation of cholesterol 7alpha-hydroxylase expression and the increase in fecal total bile acid excretion.	Capsaicin	36-49	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	138-168
23738005-4	2013	It is found that bilateral subdiaphragmatic vagotomy and treatment of capsaicin, an excitotoxin for primary afferent neurons, could both block the anorectic effect of peripherally injected SCT.	Capsaicin	70-79	secretin	Homo sapiens	189-192
23453732-5	2013	Activation of peripheral TRPV1 via painful stimuli or capsaicin has been shown to have cardioprotective effects, whereas genetic abrogation of TRPV1 results in increased myocardial damage after ischemia and reperfusion injury in comparison to wild-type mice.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	25-30
23562513-3	2013	We additionally investigated if nerve injury resulted in enhanced capsaicin-evoked activation of neurons in trigeminal caudalis (Vc) or nucleus of the solitary tract (NTS) based on expression of Fos-like immunoreactivity (FLI).	Capsaicin	66-75	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	195-198
23562513-3	2013	We additionally investigated if nerve injury resulted in enhanced capsaicin-evoked activation of neurons in trigeminal caudalis (Vc) or nucleus of the solitary tract (NTS) based on expression of Fos-like immunoreactivity (FLI).	Capsaicin	66-75	FLII actin remodeling protein	Homo sapiens	222-225
23224297-5	2013	application of a high dose of capsaicin releases tachykinin from capsaicin-sensitive nerves, producing acute plasma leakage and mucosal edema formation and causing depletion of mucin granules in goblet cells that results in a reduction in the number and size of Alcian blue (AB)-positive goblet cells in the rat trachea within a few minute after capsaicin application.	Capsaicin	30-39	solute carrier family 13 member 2	Rattus norvegicus	177-182
23499799-1	2013	Capsaicin, the pungent component of chilli pepper, stimulates TRPV1-expressing cells which are followed by desensitisation to subsequent exposure to capsaicin and other TRPV1 activators.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-67
23499799-1	2013	Capsaicin, the pungent component of chilli pepper, stimulates TRPV1-expressing cells which are followed by desensitisation to subsequent exposure to capsaicin and other TRPV1 activators.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	169-174
23499799-2	2013	At high systemic doses (&gt;125 mg/kg), capsaicin produces long-term changes in both tachykinin receptor and TRPV1 expression and function in rats.	Capsaicin	40-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	109-114
23499799-3	2013	However, whether desensitising (low) doses of capsaicin (~50 mg/kg) affect tachykinin receptor and TRPV1 gene expression in the short term has yet to be investigated.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
23499799-4	2013	The aim of the present study was to compare tachykinin receptor (NK1, NK2 and NK3) and TRPV1 mRNA expression 24h after administration of capsaicin (50 mg/kgs.c.).	Capsaicin	137-146	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-92
23499799-7	2013	In the cervical spinal cord of rats treated with capsaicin, NK1 and NK3 mRNA expression were reduced by 56% and 80%, respectively (P&lt;0.05), whereas NK2 and TRPV1 mRNA expression were increased 2.2- and 1.4-fold, respectively (P&lt;0.05).	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	159-164
23499799-9	2013	There was a marked 100-fold increase in cFOS mRNA expression and 100-fold decrease in NK2 mRNA expression in the whole blood of capsaicin-treated rats.	Capsaicin	128-137	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	40-44
23499799-10	2013	In conclusion, these studies show that tachykinin receptor and TRPV1 mRNA expression undergo significant changes within 24h of systemic low-dose capsaicin administration.	Capsaicin	145-154	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	63-68
23668392-13	2013	Moreover, TGF-beta1 treatment enhanced both proton- and capsaicin-induced Ca2+ influx in TRPV1-expressing MDPC-23 cells, while co-treatment with either SB431542 or roscovitine blocked this effect.	Capsaicin	56-65	transforming growth factor, beta 1	Mus musculus	10-19
23668392-13	2013	Moreover, TGF-beta1 treatment enhanced both proton- and capsaicin-induced Ca2+ influx in TRPV1-expressing MDPC-23 cells, while co-treatment with either SB431542 or roscovitine blocked this effect.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	89-94
23617777-3	2013	Capsaicinoids consumption down-regulated the mRNA levels of hepatic 3-hydroxyl-3-methylglutaryl CoA (HMG-CoA) reductase by 0.55-fold and hepatic cholesterol-7alpha-hydroxylase (CYP7A1) by 0.53-fold in the cholesterol-free diet group (P &lt; 0.05) but up-regulated the CYP7A1 level by 1.38-fold in the cholesterol-enriched diet group (P &lt; 0.05).	Capsaicin	0-13	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	145-175
23617777-3	2013	Capsaicinoids consumption down-regulated the mRNA levels of hepatic 3-hydroxyl-3-methylglutaryl CoA (HMG-CoA) reductase by 0.55-fold and hepatic cholesterol-7alpha-hydroxylase (CYP7A1) by 0.53-fold in the cholesterol-free diet group (P &lt; 0.05) but up-regulated the CYP7A1 level by 1.38-fold in the cholesterol-enriched diet group (P &lt; 0.05).	Capsaicin	0-13	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	177-183
23617777-3	2013	Capsaicinoids consumption down-regulated the mRNA levels of hepatic 3-hydroxyl-3-methylglutaryl CoA (HMG-CoA) reductase by 0.55-fold and hepatic cholesterol-7alpha-hydroxylase (CYP7A1) by 0.53-fold in the cholesterol-free diet group (P &lt; 0.05) but up-regulated the CYP7A1 level by 1.38-fold in the cholesterol-enriched diet group (P &lt; 0.05).	Capsaicin	0-13	cytochrome P450 family 7 subfamily A member 1	Rattus norvegicus	268-274
23070979-5	2013	We then quantified neuronal activation by measuring Fos immunoreactivity within the TNC in response to a facial injection of a low dose of capsaicin (1 mug/10 muL).	Capsaicin	139-148	FBJ osteosarcoma oncogene	Mus musculus	52-55
23070979-7	2013	In contrast, this low dose of capsaicin caused a 3.3-fold increase in Fos in the TNC in obese mice (p &lt; 0.001).	Capsaicin	30-39	FBJ osteosarcoma oncogene	Mus musculus	70-73
23584166-0	2013	Capsaicin mimics mechanical load-induced intracellular signaling events: involvement of TRPV1-mediated calcium signaling in induction of skeletal muscle hypertrophy.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
23584166-4	2013	Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3beta.	Capsaicin	55-64	transient receptor potential cation channel subfamily V member 1	Homo sapiens	40-45
23584166-4	2013	Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3beta.	Capsaicin	55-64	mechanistic target of rapamycin kinase	Homo sapiens	93-97
23584166-4	2013	Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3beta.	Capsaicin	55-64	ribosomal protein S6 kinase B1	Homo sapiens	99-105
23081967-5	2013	Simultaneous separation of capsaicinoids and ascorbic acid was achieved using a Gemini C18 column with a gradient elution of 0.03M phosphoric acid and methanol.	Capsaicin	27-40	Bardet-Biedl syndrome 9	Homo sapiens	87-90
23584166-4	2013	Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3beta.	Capsaicin	55-64	mitogen-activated protein kinase 3	Homo sapiens	111-117
23584166-4	2013	Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3beta.	Capsaicin	55-64	protein kinase AMP-activated non-catalytic subunit beta 1	Homo sapiens	145-149
23584166-4	2013	Here we show that administration of the TRPV1 agonist, capsaicin, induces phosphorylation of mTOR, p70S6K, S6, Erk1/2 and p38 MAPK, but not Akt, AMPK or GSK3beta.	Capsaicin	55-64	glycogen synthase kinase 3 beta	Homo sapiens	153-161
23499760-1	2013	Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear.	Capsaicin	147-156	adenylate cyclase activating polypeptide 1	Mus musculus	0-50
23332888-5	2013	Indeed, beneficial effects of dietary capsaicin, an agonist of TRPV1 receptors, were identified for improving glucose, insulin and glucagon-like peptide-1 levels.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
23274507-6	2013	Capsaicin increased c-Fos expression, a neuronal activity marker, in the spinal cord and primary somatosensory cortex both in group- and isolation-reared mice, but this effect did not differ between groups.	Capsaicin	0-9	FBJ osteosarcoma oncogene	Mus musculus	20-25
23596210-8	2013	Further, TRPM8 activation by icilin blocked capsaicin-triggered calcitonin-gene-related peptide release from colon tissue ex vivo and blocked capsaicin-triggered calcium signaling in Transient Receptor Potential Vaniloid-1 (TRPV1) and TRPM8 transfected HEK cells.	Capsaicin	44-53	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	9-14
23596210-8	2013	Further, TRPM8 activation by icilin blocked capsaicin-triggered calcitonin-gene-related peptide release from colon tissue ex vivo and blocked capsaicin-triggered calcium signaling in Transient Receptor Potential Vaniloid-1 (TRPV1) and TRPM8 transfected HEK cells.	Capsaicin	142-151	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	9-14
23596210-8	2013	Further, TRPM8 activation by icilin blocked capsaicin-triggered calcitonin-gene-related peptide release from colon tissue ex vivo and blocked capsaicin-triggered calcium signaling in Transient Receptor Potential Vaniloid-1 (TRPV1) and TRPM8 transfected HEK cells.	Capsaicin	142-151	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	183-222
23596210-8	2013	Further, TRPM8 activation by icilin blocked capsaicin-triggered calcitonin-gene-related peptide release from colon tissue ex vivo and blocked capsaicin-triggered calcium signaling in Transient Receptor Potential Vaniloid-1 (TRPV1) and TRPM8 transfected HEK cells.	Capsaicin	142-151	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	224-229
23596210-8	2013	Further, TRPM8 activation by icilin blocked capsaicin-triggered calcitonin-gene-related peptide release from colon tissue ex vivo and blocked capsaicin-triggered calcium signaling in Transient Receptor Potential Vaniloid-1 (TRPV1) and TRPM8 transfected HEK cells.	Capsaicin	142-151	transient receptor potential cation channel, subfamily M, member 8	Mus musculus	235-240
23607427-3	2013	Our previous studies show that activation of transient receptor potential vanilloid 1 (TRPV1) by capsaicin can prevent cardiometabolic disorders.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-85
23607427-3	2013	Our previous studies show that activation of transient receptor potential vanilloid 1 (TRPV1) by capsaicin can prevent cardiometabolic disorders.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	87-92
23607427-4	2013	In this study, we conducted experiments in vitro and in vivo to investigate the effect of capsaicin treatment on endothelial UCP2 and oxidative stress.	Capsaicin	90-99	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	125-129
23607427-5	2013	We hypothesised that TRPV1 activation by capsaicin attenuates hyperglycemia-induced endothelial dysfunction through a UCP2-mediated antioxidant effect.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	21-26
23607427-5	2013	We hypothesised that TRPV1 activation by capsaicin attenuates hyperglycemia-induced endothelial dysfunction through a UCP2-mediated antioxidant effect.	Capsaicin	41-50	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	118-122
23607427-10	2013	RESULTS: Under high-glucose conditions, TRPV1 expression and protein kinase A (PKA) phosphorylation were found to be decreased in the cultured endothelial cells, and the effects of high-glucose on these molecules were reversed by the administration of capsaicin.	Capsaicin	252-261	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-45
23607427-12	2013	Capsaicin administration decreased the production of ROS, restored high-glucose-induced endothelial dysfunction through the activation of TRPV1 and acted in a UCP2-dependent manner in vivo.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	138-143
23607427-12	2013	Capsaicin administration decreased the production of ROS, restored high-glucose-induced endothelial dysfunction through the activation of TRPV1 and acted in a UCP2-dependent manner in vivo.	Capsaicin	0-9	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	159-163
23607427-13	2013	Administration of dietary capsaicin for 14 weeks increased the levels of PKA phosphorylation and UCP2 expression, ameliorated the vascular oxidative stress and increased NO levels observed in diabetic mice.	Capsaicin	26-35	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	97-101
23607427-16	2013	CONCLUSION: TRPV1 activation by capsaicin might protect against hyperglycemia-induced endothelial dysfunction through a mechanism involving the PKA/UCP2 pathway.	Capsaicin	32-41	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	12-17
23607427-16	2013	CONCLUSION: TRPV1 activation by capsaicin might protect against hyperglycemia-induced endothelial dysfunction through a mechanism involving the PKA/UCP2 pathway.	Capsaicin	32-41	uncoupling protein 2 (mitochondrial, proton carrier)	Mus musculus	148-152
23499760-1	2013	Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear.	Capsaicin	147-156	adenylate cyclase activating polypeptide 1	Mus musculus	52-57
23499760-1	2013	Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear.	Capsaicin	147-156	tachykinin 1	Mus musculus	63-67
23499760-1	2013	Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear.	Capsaicin	147-156	tachykinin 1	Mus musculus	94-105
23499760-1	2013	Pituitary Adenylate-Cyclase Activating Polypeptide (PACAP) and Tac1 gene-encoded tachykinins (substance P: SP, neurokinin A: NKA) are expressed in capsaicin-sensitive nerves, but their role in nociception, inflammation and vasoregulation is unclear.	Capsaicin	147-156	tachykinin 1	Mus musculus	111-123
23481698-4	2013	To address this question, we first determined if selective lesions of capsaicin-sensitive vagal afferents altered c-Fos expression in the nucleus of the solitary tract (nTS) after mice were inoculated with either Campylobacter jejuni or Salmonella typhimurium.	Capsaicin	70-79	FBJ osteosarcoma oncogene	Mus musculus	114-119
23481698-8	2013	We found that tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS) directly activate cultured vagal afferent neurons and that almost all TNFalpha and LPS responsive neurons were sensitive to capsaicin.	Capsaicin	206-215	tumor necrosis factor	Mus musculus	14-41
23481698-8	2013	We found that tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS) directly activate cultured vagal afferent neurons and that almost all TNFalpha and LPS responsive neurons were sensitive to capsaicin.	Capsaicin	206-215	tumor necrosis factor	Mus musculus	43-51
23481698-8	2013	We found that tumor necrosis factor alpha (TNFalpha) and lipopolysaccharide (LPS) directly activate cultured vagal afferent neurons and that almost all TNFalpha and LPS responsive neurons were sensitive to capsaicin.	Capsaicin	206-215	tumor necrosis factor	Mus musculus	152-160
23274964-0	2013	Capsaicin up-regulates protease-activated receptor-4 mRNA and protein in primary cultured dorsal root ganglion neurons.	Capsaicin	0-9	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	23-52
23574808-1	2013	BACKGROUND: Nasal insufflation of CO2 has been shown to exert antinociceptive respectively antihyperalgesic effects in animal pain models using topical capsaicin with activation of TRPV1-receptor positive nociceptive neurons.	Capsaicin	152-161	transient receptor potential cation channel subfamily V member 1	Homo sapiens	181-186
23274964-2	2013	Capsaicin activation of TRPV1 is involved in enhancement of the expression of TRPV1 in mRNA and protein in dorsal root ganglion (DRG) in vivo.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
23274964-2	2013	Capsaicin activation of TRPV1 is involved in enhancement of the expression of TRPV1 in mRNA and protein in dorsal root ganglion (DRG) in vivo.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-83
23274964-3	2013	Whether capsaicin could influence expression of PAR4 in primary sensory neurons remains unknown.	Capsaicin	8-17	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	48-52
23324998-4	2013	Intravitreal injections of the classical TRPV1 agonist capsaicin up-regulated the protein expression of the inducible and endothelial NOS isoforms.	Capsaicin	55-64	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
23274964-4	2013	In the present study, expression of PAR4 in cultured rat DRG neurons was observed using immunofluorescence, real-time PCR and Western blots to examine whether increases in PAR4 mRNA and protein levels are induced by capsaicin treatment with or without pre-treatment of forskolin, a cyclic AMP/protein kinase A (cAMP/PKA) activator or PKA inhibitor fragment 14-22 (PKI14-22), a PKA inhibitor.	Capsaicin	216-225	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	36-40
23274964-4	2013	In the present study, expression of PAR4 in cultured rat DRG neurons was observed using immunofluorescence, real-time PCR and Western blots to examine whether increases in PAR4 mRNA and protein levels are induced by capsaicin treatment with or without pre-treatment of forskolin, a cyclic AMP/protein kinase A (cAMP/PKA) activator or PKA inhibitor fragment 14-22 (PKI14-22), a PKA inhibitor.	Capsaicin	216-225	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	172-176
23274964-5	2013	Capsaicin treatment of cultured DRG neurons significantly increased the expression of PAR4 in mRNA and protein levels.	Capsaicin	0-9	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	86-90
23274964-6	2013	The percentage of PAR4-, TRPV1-immunoreactive neurons and their co-localization in cultured DRG neurons increased significantly in the presence of capsaicin as compared with that in the absence of capsaicin.	Capsaicin	147-156	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	18-22
23274964-6	2013	The percentage of PAR4-, TRPV1-immunoreactive neurons and their co-localization in cultured DRG neurons increased significantly in the presence of capsaicin as compared with that in the absence of capsaicin.	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	25-30
23430271-0	2013	Capsaicin-induced activation of ERK1/2 and its involvement in GAP-43 expression and CGRP depletion in organotypically cultured DRG neurons.	Capsaicin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	32-38
23430271-0	2013	Capsaicin-induced activation of ERK1/2 and its involvement in GAP-43 expression and CGRP depletion in organotypically cultured DRG neurons.	Capsaicin	0-9	growth associated protein 43	Rattus norvegicus	62-68
23430271-0	2013	Capsaicin-induced activation of ERK1/2 and its involvement in GAP-43 expression and CGRP depletion in organotypically cultured DRG neurons.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	84-88
23430271-2	2013	CAP induces the phosphorylation of extracellular signal-regulated protein kinases 1/2 (ERK1/2) in DRG neurons.	Capsaicin	0-3	mitogen activated protein kinase 3	Rattus norvegicus	87-93
23274964-7	2013	Compared with capsaicin-only group, pre-incubation with forskolin strongly enhanced the capsaicin-induced increase of PAR4 in mRNA and protein levels.	Capsaicin	88-97	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	118-122
23274964-9	2013	Taken together, these results provide evidence that TRPV1 activation significantly increases the expression of PAR4 mRNA and protein levels in primary cultures of DRG neurons after capsaicin incubation.	Capsaicin	181-190	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-57
23274964-9	2013	Taken together, these results provide evidence that TRPV1 activation significantly increases the expression of PAR4 mRNA and protein levels in primary cultures of DRG neurons after capsaicin incubation.	Capsaicin	181-190	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	111-115
23274964-10	2013	Effects of capsaicin on PAR4 expression appear to be mediated by cAMP/PKA signal pathways in DRG neurons.	Capsaicin	11-20	F2R like thrombin or trypsin receptor 3	Rattus norvegicus	24-28
23596498-10	2013	These results suggest that propofol binds to TRPV1 at the capsaicin-binding pocket.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-50
23596498-2	2013	Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1).	Capsaicin	70-79	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	88-134
23396520-4	2013	During whole-cell patch-clamp recording, endothelin-1 enhanced an induced current in response to capsaicin, a TRPV1 agonist, in approximately 20% of dissociated neurons.	Capsaicin	97-106	endothelin 1	Rattus norvegicus	41-53
23596498-2	2013	Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1).	Capsaicin	70-79	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	136-141
23596498-2	2013	Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1).	Capsaicin	70-79	protein kinase C, epsilon	Mus musculus	147-170
23596498-2	2013	Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1).	Capsaicin	70-79	protein kinase C, epsilon	Mus musculus	172-182
23596498-2	2013	Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1).	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	212-260
23596498-2	2013	Propofol increases the sensitivity of dorsal root ganglion neurons to capsaicin through transient receptor potential ankyrin subtype-1 (TRPA1) and protein kinase Cepsilon (PKCepsilon)-mediated phosphorylation of transient receptor potential vanilloid subtype-1 (TRPV1).	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	262-267
23303863-2	2013	Coapplication of external QX-314 with the transient receptor potential vanilloid 1 protein (TRPV1) agonist capsaicin produces long-lasting sodium channel inhibition in TRPV1-expressing neurons, suggestive of QX-314 entry into the neurons.	Capsaicin	107-116	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	92-97
23303863-2	2013	Coapplication of external QX-314 with the transient receptor potential vanilloid 1 protein (TRPV1) agonist capsaicin produces long-lasting sodium channel inhibition in TRPV1-expressing neurons, suggestive of QX-314 entry into the neurons.	Capsaicin	107-116	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	168-173
23398938-2	2013	The transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated ion channel expressed on sensory neurons responding to noxious heat, protons, and chemical stimuli such as capsaicin.	Capsaicin	178-187	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-44
23398938-2	2013	The transient receptor potential vanilloid 1 (TRPV1) is a ligand-gated ion channel expressed on sensory neurons responding to noxious heat, protons, and chemical stimuli such as capsaicin.	Capsaicin	178-187	transient receptor potential cation channel subfamily V member 1	Homo sapiens	46-51
23398938-7	2013	Opioid withdrawal significantly increased cAMP levels and capsaicin-induced TRPV1 activity in both transfected human embryonic kidney 293 cells and dissociated dorsal root ganglion (DRG) neurons.	Capsaicin	58-67	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
23396520-4	2013	During whole-cell patch-clamp recording, endothelin-1 enhanced an induced current in response to capsaicin, a TRPV1 agonist, in approximately 20% of dissociated neurons.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	110-115
23352977-1	2013	AIMS: Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	44-84
23985252-8	2013	Immunohistochemistry showed that the cytoplasmic expression of HSP27 was strongly positive in the group NS, and significantly reduced with the increasing dose of capsaicin in the treated groups.	Capsaicin	162-171	heat shock protein 1	Mus musculus	63-68
23985252-9	2013	The expression of active caspase-3 and Cyt-C in the group NS was weakly positive, and was significantly increased with the increasing dose of capsaicin in the groups C5 and C10 (P &lt; 0.05), and the expression of active caspase-3 and Cyt-C of the group C20 was significantly higher than that of the groups C5, C10 and NS (P &lt; 0.01).	Capsaicin	142-151	caspase 3	Mus musculus	25-34
23985252-9	2013	The expression of active caspase-3 and Cyt-C in the group NS was weakly positive, and was significantly increased with the increasing dose of capsaicin in the groups C5 and C10 (P &lt; 0.05), and the expression of active caspase-3 and Cyt-C of the group C20 was significantly higher than that of the groups C5, C10 and NS (P &lt; 0.01).	Capsaicin	142-151	gene rich cluster, C10 gene	Mus musculus	173-176
23985252-9	2013	The expression of active caspase-3 and Cyt-C in the group NS was weakly positive, and was significantly increased with the increasing dose of capsaicin in the groups C5 and C10 (P &lt; 0.05), and the expression of active caspase-3 and Cyt-C of the group C20 was significantly higher than that of the groups C5, C10 and NS (P &lt; 0.01).	Capsaicin	142-151	caspase 3	Mus musculus	221-230
23985252-9	2013	The expression of active caspase-3 and Cyt-C in the group NS was weakly positive, and was significantly increased with the increasing dose of capsaicin in the groups C5 and C10 (P &lt; 0.05), and the expression of active caspase-3 and Cyt-C of the group C20 was significantly higher than that of the groups C5, C10 and NS (P &lt; 0.01).	Capsaicin	142-151	gene rich cluster, C10 gene	Mus musculus	311-314
23470198-6	2013	Additionally, complex I also inhibited transient receptor potential cation channel subfamily V member 1 (TRPV1)-dependent overt pain-like behavior induced by capsaicin.	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-110
23297311-5	2013	Immunohistochemical analyses demonstrated that, as following vagotomy, capsaicin induced dendritic degeneration, decreased choline acetyltransferase but increased nitric oxide synthase immunoreactivity in rat dorsal motor nucleus of the vagus (DMV) neurones.	Capsaicin	71-80	choline O-acetyltransferase	Rattus norvegicus	123-148
23352977-1	2013	AIMS: Although capsaicin not only activates transient receptor potential vanilloid-1 (TRPV1) channels but also inhibits nerve conduction, the latter action has not yet been fully examined.	Capsaicin	15-24	transient receptor potential cation channel subfamily V member 1	Homo sapiens	86-91
23402980-0	2013	Contribution of TRPV1 and multidrug resistance proteins in the permeation of capsaicin across different intestinal regions.	Capsaicin	77-86	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	16-21
23402980-2	2013	The interaction of capsaicin with P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP) was also investigated.	Capsaicin	19-28	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	34-48
23402980-2	2013	The interaction of capsaicin with P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP) was also investigated.	Capsaicin	19-28	ATP-binding cassette, subfamily B (MDR/TAP), member 1B	Rattus norvegicus	50-54
23402980-2	2013	The interaction of capsaicin with P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP) was also investigated.	Capsaicin	19-28	ATP binding cassette subfamily C member 2	Rattus norvegicus	57-98
23402980-2	2013	The interaction of capsaicin with P-glycoprotein (P-gp), multidrug resistance-associated protein 2 (MRP2) and breast cancer resistance protein (BCRP) was also investigated.	Capsaicin	19-28	ATP binding cassette subfamily C member 2	Rattus norvegicus	100-104
23402980-5	2013	TRPV1 non-competitive antagonist ruthenium red significantly decreased the permeability of capsaicin in M-S direction across colonic membrane.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
23402980-9	2013	Furthermore, TRPV1 might mediate the transport of capsaicin across the intestinal membrane.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
23402980-10	2013	Therefore, the colon-specific highest permeation of capsaicin could be the consequence of the colon-specific distribution of TRPV1.	Capsaicin	52-61	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	125-130
23299362-3	2013	METHODS: The authors evaluated the role of sigma1 receptors in intracolonic capsaicin-induced visceral pain (pain-related behaviors and referred mechanical hyperalgesia to the abdominal wall) using wild-type (WT) (n = 12 per group) and sigma1 receptor knockout (sigma1-KO) (n = 10 per group) mice, selective sigma1 receptor antagonists (BD-1063, S1RA, and NE-100), and control drugs (morphine and ketoprofen).	Capsaicin	76-85	sigma non-opioid intracellular receptor 1	Mus musculus	43-58
24358880-4	2013	Capsaicin, for example, activates transient receptor potential vanilloid 1 (TRPV1) channels.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	34-74
24358880-4	2013	Capsaicin, for example, activates transient receptor potential vanilloid 1 (TRPV1) channels.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	76-81
23497345-15	2013	DRG neurons from WT mice exhibited sensitization to TRPV1 activation, as more neurons (66%) from skin-incised mice responded to capsaicin compared to controls (46%), and the sensitization occurred specifically in isolectin B4 (IB4)-positive neurons where 80% of incised neurons responded to capsaicin compared to just 44% of controls.	Capsaicin	128-137	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
23497345-15	2013	DRG neurons from WT mice exhibited sensitization to TRPV1 activation, as more neurons (66%) from skin-incised mice responded to capsaicin compared to controls (46%), and the sensitization occurred specifically in isolectin B4 (IB4)-positive neurons where 80% of incised neurons responded to capsaicin compared to just 44% of controls.	Capsaicin	291-300	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
23264033-6	2013	In response to heat activation or vanilloid treatment, Co(2+) accumulation was verified in TRPV1-transfected cell lines and in the TRPV1+ dorsal root ganglion neurons.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
23220012-1	2013	The vanilloid transient receptor potential channel TRPV1 is a molecular integrator of noxious stimuli, including capsaicin, heat and protons.	Capsaicin	113-122	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
23264033-6	2013	In response to heat activation or vanilloid treatment, Co(2+) accumulation was verified in TRPV1-transfected cell lines and in the TRPV1+ dorsal root ganglion neurons.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	131-136
23345400-11	2013	Furthermore, either PD98059 or ML-7 could abolish the capsaicin-induced TER response and occludin redistribution, whereas knockdown of ERK1/2 further confirmed that the TRPV1-modulated paracellular permeability was ERK1/2 dependent.	Capsaicin	54-63	mitogen activated protein kinase 3	Rattus norvegicus	135-141
23345400-4	2013	Both TRPV1 and occludin were expressed in SMG-C6 cells, and capsaicin induced redistribution of occludin, but not claudin-3, claudin-4 or E-cadherin, from the cell membrane into the cytoplasm.	Capsaicin	60-69	occludin	Rattus norvegicus	96-104
22647236-2	2013	Transient receptor potential vanilloid receptor 1 (TRPV1), a member of the transient receptor potential family, is the capsaicin receptor and is known to be involved in peripheral nociception.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-49
22647236-2	2013	Transient receptor potential vanilloid receptor 1 (TRPV1), a member of the transient receptor potential family, is the capsaicin receptor and is known to be involved in peripheral nociception.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
23111447-0	2013	TRPV1 properties in thoracic dorsal root ganglia neurons are modulated by intraperitoneal capsaicin administration in the late phase of type-1 autoimmune diabetes.	Capsaicin	90-99	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
23111447-2	2013	Transient receptor potential vanilloid type 1 (TRPV1) from dorsal root ganglia (DRG) neurons is one of the main pharmacological targets in diabetes, and its ligand capsaicin can be a promising compound for blood-glucose control.	Capsaicin	164-173	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-45
23111447-2	2013	Transient receptor potential vanilloid type 1 (TRPV1) from dorsal root ganglia (DRG) neurons is one of the main pharmacological targets in diabetes, and its ligand capsaicin can be a promising compound for blood-glucose control.	Capsaicin	164-173	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	47-52
23111447-4	2013	capsaicin administration in type 1 diabetic mice against TRPV1 receptors from pancreatic DRG primary afferent neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	57-62
23111447-8	2013	A TRPV1 hypoalgesia profile was observed in late-phase diabetes, which was partly reversed to normoalgesic profile upon capsaicin i.p.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	2-7
23111447-10	2013	According to the soma dimensions of the thoracic DRG neurons, a detailed analysis of the TRPV1 expression upon capsaicin i.p.	Capsaicin	111-120	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	89-94
23111447-11	2013	treatment was done, and the proportion of large A-fiber neurons expressing TRPV1 increased in dTg capsaicin-treated mice.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	75-80
23324098-1	2013	The aim of the present study was to investigate the effects of AZD1940, a novel peripherally acting cannabinoid CB(1) /CB(2) receptor agonist, on capsaicin-induced pain and hyperalgesia, as well as on biomarkers of cannabinoid central nervous system (CNS) effects.	Capsaicin	146-155	cannabinoid receptor 1	Homo sapiens	112-117
23274405-4	2013	RECENT FINDINGS: TRPV1 may be activated by exogenous vanilloid or endo-vanilloid compounds and its function modulated by vasoactive mediators.	Capsaicin	53-62	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
23274405-4	2013	RECENT FINDINGS: TRPV1 may be activated by exogenous vanilloid or endo-vanilloid compounds and its function modulated by vasoactive mediators.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
23345400-6	2013	Capsazepine (CPZ), a TRPV1 antagonist, inhibited the capsaicin-induced occludin redistribution and TER decrease.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	21-26
23345400-6	2013	Capsazepine (CPZ), a TRPV1 antagonist, inhibited the capsaicin-induced occludin redistribution and TER decrease.	Capsaicin	53-62	occludin	Rattus norvegicus	71-79
23345400-7	2013	Moreover, occludin knockdown by shRNA suppressed, whereas occludin re-expression restored, the TER response to capsaicin.	Capsaicin	111-120	occludin	Rattus norvegicus	10-18
23345400-7	2013	Moreover, occludin knockdown by shRNA suppressed, whereas occludin re-expression restored, the TER response to capsaicin.	Capsaicin	111-120	occludin	Rattus norvegicus	58-66
23345400-9	2013	PD98059, an ERK1/2 kinase inhibitor, abolished the capsaicin-induced MLC2 phosphorylation, whereas ML-7, an MLC2 kinase inhibitor, did not affect ERK1/2 phosphorylation, suggesting that ERK1/2 is the upstream signaling molecule of MLC2.	Capsaicin	51-60	mitogen activated protein kinase 3	Rattus norvegicus	12-18
23345400-9	2013	PD98059, an ERK1/2 kinase inhibitor, abolished the capsaicin-induced MLC2 phosphorylation, whereas ML-7, an MLC2 kinase inhibitor, did not affect ERK1/2 phosphorylation, suggesting that ERK1/2 is the upstream signaling molecule of MLC2.	Capsaicin	51-60	myosin light chain 2	Rattus norvegicus	69-73
23345400-10	2013	Capsaicin also induced F-actin reorganization, which was abolished by CPZ, PD98059 and ML-7, indicating that TRPV1 activation altered F-actin organization in an ERK1/2- and MLC2-dependent manner.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	109-114
23345400-11	2013	Furthermore, either PD98059 or ML-7 could abolish the capsaicin-induced TER response and occludin redistribution, whereas knockdown of ERK1/2 further confirmed that the TRPV1-modulated paracellular permeability was ERK1/2 dependent.	Capsaicin	54-63	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	169-174
23345400-10	2013	Capsaicin also induced F-actin reorganization, which was abolished by CPZ, PD98059 and ML-7, indicating that TRPV1 activation altered F-actin organization in an ERK1/2- and MLC2-dependent manner.	Capsaicin	0-9	mitogen activated protein kinase 3	Rattus norvegicus	161-167
23345400-11	2013	Furthermore, either PD98059 or ML-7 could abolish the capsaicin-induced TER response and occludin redistribution, whereas knockdown of ERK1/2 further confirmed that the TRPV1-modulated paracellular permeability was ERK1/2 dependent.	Capsaicin	54-63	mitogen activated protein kinase 3	Rattus norvegicus	215-221
23345400-10	2013	Capsaicin also induced F-actin reorganization, which was abolished by CPZ, PD98059 and ML-7, indicating that TRPV1 activation altered F-actin organization in an ERK1/2- and MLC2-dependent manner.	Capsaicin	0-9	myosin light chain 2	Rattus norvegicus	173-177
23433093-13	2013	Moreover, capsaicin induced disruption of the mitochondrial membrane potential as well as activation of caspase 9, 3 and poly-(ADP-ribose) polymerase in KB cells.	Capsaicin	10-19	caspase 9	Homo sapiens	104-113
23171089-3	2013	Transient receptor potential vanilloid-1 (TRPV(1)) pathways are involved in gastric mechanosensory physiology and the TRPV(1) receptor agonist, capsaicin, has been used as a chemical stimulant.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
23171089-3	2013	Transient receptor potential vanilloid-1 (TRPV(1)) pathways are involved in gastric mechanosensory physiology and the TRPV(1) receptor agonist, capsaicin, has been used as a chemical stimulant.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-49
23171089-3	2013	Transient receptor potential vanilloid-1 (TRPV(1)) pathways are involved in gastric mechanosensory physiology and the TRPV(1) receptor agonist, capsaicin, has been used as a chemical stimulant.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-125
23433093-13	2013	Moreover, capsaicin induced disruption of the mitochondrial membrane potential as well as activation of caspase 9, 3 and poly-(ADP-ribose) polymerase in KB cells.	Capsaicin	10-19	poly(ADP-ribose) polymerase 1	Homo sapiens	121-149
23201260-10	2013	Additionally, in a subpopulation of P2Xv/TRPV1 positive neurons, capsaicin-induced Ca(2+) transients were significantly amplified following P2X3 activation.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	41-46
23266932-3	2013	We found that, following intrathecal injection of capsaicin to eliminate the central terminals of TRPV1+ nociceptors, neurons in the region of laminae I and V of the spinal cord lost responsiveness to noxious heat (whether generated by a contact heat probe or diode laser), with no change in their response to noxious mechanical stimulation.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	98-103
23201260-10	2013	Additionally, in a subpopulation of P2Xv/TRPV1 positive neurons, capsaicin-induced Ca(2+) transients were significantly amplified following P2X3 activation.	Capsaicin	65-74	purinergic receptor P2X 3	Rattus norvegicus	140-144
23421753-8	2013	Pain behavioural analysis of the hph-1 mice showed reduced pain-like responses following intraplantar injection of CFA, formalin and capsaicin; whereas decreased basal level of GTP-CH1 activity had no influence in naive hph-1 mice on acute mechanical and heat pain thresholds.	Capsaicin	133-142	hyperphenylalaninemia 1	Mus musculus	33-38
23439120-2	2013	Here, we reconstitute purified TRPV1 into artificial liposomes, where it is gated robustly by capsaicin, protons, spider toxins, and, notably, heat, demonstrating intrinsic sensitivity of the channel to both chemical and thermal stimuli.	Capsaicin	94-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
23340220-4	2013	This effect was independent of a functional endothelium but was blocked by the Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor antagonist SB366791 (2muM) or prolonged treatment with the TRPV1 agonist capsaicin (10muM).	Capsaicin	215-224	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	126-131
23340220-4	2013	This effect was independent of a functional endothelium but was blocked by the Transient Receptor Potential Vanilloid type 1 (TRPV1) receptor antagonist SB366791 (2muM) or prolonged treatment with the TRPV1 agonist capsaicin (10muM).	Capsaicin	215-224	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	201-206
23413875-5	2013	Instead, pinosylvin methyl ether (PME), another derivate of stilbene which has a similar structure to resveratrol, dose-dependently blocked the capsaicin-induced currents (I CAP) in HEK293 cells that express TRPV1 as well as in DRG neurons.	Capsaicin	144-153	transient receptor potential cation channel subfamily V member 1	Homo sapiens	208-213
23232207-6	2013	Single-cell fluorescence imaging detected in fura2-AM loaded cells Ca(2+) transients that rose 1.8-fold above the baseline induced by a selective TRPV1 agonist, capsaicin (CAP), which were blocked by a TRPV1 antagonist, capsazepine (CPZ) or exposure to a Ca(2+) free medium.	Capsaicin	161-170	transient receptor potential cation channel subfamily V member 1	Homo sapiens	146-151
23264624-6	2013	The anchoring of AC to this complex generates local pools of cAMP, shifting the concentration of forskolin required to attenuate capsaicin-dependent TRPV1 desensitization by ~100-fold.	Capsaicin	129-138	transient receptor potential cation channel subfamily V member 1	Homo sapiens	149-154
23062150-7	2013	We also show that the pharmacological profile of diverse TRPV1 antagonists is dependent on whether the stimulus is PDBu or capsaicin.	Capsaicin	123-132	transient receptor potential cation channel subfamily V member 1	Homo sapiens	57-62
23232207-6	2013	Single-cell fluorescence imaging detected in fura2-AM loaded cells Ca(2+) transients that rose 1.8-fold above the baseline induced by a selective TRPV1 agonist, capsaicin (CAP), which were blocked by a TRPV1 antagonist, capsazepine (CPZ) or exposure to a Ca(2+) free medium.	Capsaicin	161-170	transient receptor potential cation channel subfamily V member 1	Homo sapiens	202-207
23263443-5	2013	Notably, mice in which TRPV1 was exclusively expressed in MrgprA3(+) neurons exhibited itch, but not pain, behavior in response to capsaicin.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
22918689-1	2013	Calcitonin gene-related peptide (CGRP) is a predominant neurotransmitter from capsaicin-sensitive sensory nerves, which are widely distributed in the gastrointestinal system.	Capsaicin	78-87	calcitonin related polypeptide alpha	Homo sapiens	0-31
22918689-1	2013	Calcitonin gene-related peptide (CGRP) is a predominant neurotransmitter from capsaicin-sensitive sensory nerves, which are widely distributed in the gastrointestinal system.	Capsaicin	78-87	calcitonin related polypeptide alpha	Homo sapiens	33-37
22918689-5	2013	So far, multiple TRPV1 agonists, including capsaicin, capsiate, anandamide and rutaecarpine are reported to exert beneficial effects on gastric mucosal injury induced by various stimuli.	Capsaicin	43-52	transient receptor potential cation channel subfamily V member 1	Homo sapiens	17-22
22587561-5	2013	The function of TRPV1 was studied using capsaicin, a well-known TRPV1 agonist.	Capsaicin	40-49	transient receptor potential cation channel subfamily V member 1	Homo sapiens	16-21
22587561-8	2013	The mechanisms of capsaicin-induced OPG expression in HPDL cells were studied using inhibitors.	Capsaicin	18-27	TNF receptor superfamily member 11b	Homo sapiens	36-39
22587561-10	2013	Treatment with capsaicin induced OPG expression in a dose-dependent manner but did not affect the expression of RANKL.	Capsaicin	15-24	TNF receptor superfamily member 11b	Homo sapiens	33-36
22587561-12	2013	Capsazepine, the competitive TRPV1 antagonist, significantly abolished the effect of capsaicin on OPG expression in HPDL cells.	Capsaicin	85-94	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
22587561-12	2013	Capsazepine, the competitive TRPV1 antagonist, significantly abolished the effect of capsaicin on OPG expression in HPDL cells.	Capsaicin	85-94	TNF receptor superfamily member 11b	Homo sapiens	98-101
22587561-14	2013	Interestingly, capsaicin was able to increase the OPG/RANKL ratio, even in the presence of prostaglandin E2, a potent inducer of RANKL.	Capsaicin	15-24	TNF receptor superfamily member 11b	Homo sapiens	50-53
22587561-14	2013	Interestingly, capsaicin was able to increase the OPG/RANKL ratio, even in the presence of prostaglandin E2, a potent inducer of RANKL.	Capsaicin	15-24	TNF superfamily member 11	Homo sapiens	54-59
22587561-14	2013	Interestingly, capsaicin was able to increase the OPG/RANKL ratio, even in the presence of prostaglandin E2, a potent inducer of RANKL.	Capsaicin	15-24	TNF superfamily member 11	Homo sapiens	129-134
23263443-5	2013	Notably, mice in which TRPV1 was exclusively expressed in MrgprA3(+) neurons exhibited itch, but not pain, behavior in response to capsaicin.	Capsaicin	131-140	MAS-related GPR, member A3	Mus musculus	58-65
23386808-6	2013	The early increase in mEPSCs was mimicked by activation of transient receptor potential vanilloid type 1 (TRPV1) receptors with capsaicin and by activation of TRPV4 receptors with 4-alpha-PDD.	Capsaicin	128-137	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	59-104
23098993-4	2013	Pharmacological blockade of local TRPA1 by its selective antagonist HC 030031 prevented and reversed carrageenan-induced hyperalgesia, which was detected either by a mechanical or chemical (low dose of capsaicin) stimulus.	Capsaicin	202-211	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	34-39
23386808-6	2013	The early increase in mEPSCs was mimicked by activation of transient receptor potential vanilloid type 1 (TRPV1) receptors with capsaicin and by activation of TRPV4 receptors with 4-alpha-PDD.	Capsaicin	128-137	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	106-111
23273136-7	2013	Notably, the oral administration of 1 (100 mg/kg) inhibited significantly the capsaicin-induced increase of c-Fos and COX-2 labeling in the spinal cord and COX-2 expression in the cortex, but failed to affect c-Fos and COX-2 expression in the glutamate model.	Capsaicin	78-87	cytochrome c oxidase II, mitochondrial	Mus musculus	118-123
23273136-7	2013	Notably, the oral administration of 1 (100 mg/kg) inhibited significantly the capsaicin-induced increase of c-Fos and COX-2 labeling in the spinal cord and COX-2 expression in the cortex, but failed to affect c-Fos and COX-2 expression in the glutamate model.	Capsaicin	78-87	FBJ osteosarcoma oncogene	Mus musculus	108-113
23273136-7	2013	Notably, the oral administration of 1 (100 mg/kg) inhibited significantly the capsaicin-induced increase of c-Fos and COX-2 labeling in the spinal cord and COX-2 expression in the cortex, but failed to affect c-Fos and COX-2 expression in the glutamate model.	Capsaicin	78-87	cytochrome c oxidase II, mitochondrial	Mus musculus	156-161
23273136-7	2013	Notably, the oral administration of 1 (100 mg/kg) inhibited significantly the capsaicin-induced increase of c-Fos and COX-2 labeling in the spinal cord and COX-2 expression in the cortex, but failed to affect c-Fos and COX-2 expression in the glutamate model.	Capsaicin	78-87	cytochrome c oxidase II, mitochondrial	Mus musculus	156-161
23279936-4	2013	Prolonged capsaicin-induced activation of TRPV1 with N-methyl-D-glucamine (NMDG) as the sole extracellular cation, generated a biphasic current which included an initial outward current followed by an inward current.	Capsaicin	10-19	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	42-47
23088752-0	2013	Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.	Capsaicin	59-68	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	94-98
23088752-0	2013	Reactive intermediates produced from the metabolism of the vanilloid ring of capsaicinoids by p450 enzymes.	Capsaicin	77-90	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	94-98
23088752-1	2013	This study characterized electrophilic and radical products derived from the metabolism of capsaicin by cytochrome P450 and peroxidase enzymes.	Capsaicin	91-100	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	115-119
23088752-2	2013	Multiple glutathione and beta-mercaptoethanol conjugates (a.k.a., adducts), derived from the trapping of quinone methide and quinone intermediates of capsaicin, its analogue nonivamide, and O-demethylated and aromatic hydroxylated metabolites thereof, were produced by human liver microsomes and individual recombinant human P450 enzymes.	Capsaicin	150-159	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	325-329
23088752-7	2013	These data demonstrated that capsaicin and structurally similar analogues are converted to reactive intermediates by certain P450 enzymes, which may partially explain conflicting reports related to the cytotoxic, pro-carcinogenic, and chemoprotective effects of capsaicinoids in different cells and/or organ systems.	Capsaicin	29-38	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	125-129
23088752-7	2013	These data demonstrated that capsaicin and structurally similar analogues are converted to reactive intermediates by certain P450 enzymes, which may partially explain conflicting reports related to the cytotoxic, pro-carcinogenic, and chemoprotective effects of capsaicinoids in different cells and/or organ systems.	Capsaicin	262-275	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	125-129
23283344-4	2013	Using tandem mass spectrometry we show that upon activation with capsaicin, QX-314 selectively accumulates in the cytosol only of TRPV1-expressing cells, and not in control cells.	Capsaicin	65-74	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	130-135
23283344-5	2013	Exposure to QX-314 and capsaicin induces in small DRG neurons a robust sodium current block within 30 s. In sciatic nerves, application of extracellular QX-314 with capsaicin persistently reduces C-fiber but not A-fiber compound action potentials and this effect does not occur in TRPV1(-/-) mice.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	281-286
23283344-5	2013	Exposure to QX-314 and capsaicin induces in small DRG neurons a robust sodium current block within 30 s. In sciatic nerves, application of extracellular QX-314 with capsaicin persistently reduces C-fiber but not A-fiber compound action potentials and this effect does not occur in TRPV1(-/-) mice.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	281-286
23283344-6	2013	Behavioral phenotyping after selectively silencing TRPV1(+) sciatic nerve axons by perineural injections of QX-314 and capsaicin reveals deficits in heat and mechanical pressure but not pinprick or light touch perception.	Capsaicin	119-128	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	51-56
23139219-0	2013	Capsaicin induces NKCC1 internalization and inhibits chloride secretion in colonic epithelial cells independently of TRPV1.	Capsaicin	0-9	solute carrier family 12 member 2	Homo sapiens	18-23
23139219-4	2013	Capsaicin is known to activate the transient receptor potential vanilloid type 1 (TRPV1), expressed in the mesenteric nervous system.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	35-80
23139219-4	2013	Capsaicin is known to activate the transient receptor potential vanilloid type 1 (TRPV1), expressed in the mesenteric nervous system.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	82-87
23139219-10	2013	In permeabilized monolayers, capsaicin activated apical chloride conductance, had no effect on basolateral potassium conductance, but induced NKCC1 internalization demonstrated by immunocytochemistry and basolateral surface biotinylation.	Capsaicin	29-38	solute carrier family 12 member 2	Homo sapiens	142-147
23139219-14	2013	We conclude that capsaicin inhibits chloride secretion in part by causing NKCC1 internalization, but by a mechanism that appears to be independent of TRPV1.	Capsaicin	17-26	solute carrier family 12 member 2	Homo sapiens	74-79
23279936-7	2013	Our findings show that cholesterol depletion inhibited both the second current, and the increase in ion-permeability of the TRPV1 channel, resulting from sustained agonist-activation with capsaicin and protons (pH 5.5).	Capsaicin	188-197	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	124-129
23013364-0	2013	Effects of capsaicin on testis ghrelin expression in mice.	Capsaicin	11-20	ghrelin	Mus musculus	31-38
22826051-8	2013	The inter-individual C5 capsaicin responsiveness reflected a representative range (0.95-1000 muM).	Capsaicin	24-33	latexin	Homo sapiens	93-96
22982038-7	2013	Since we have recently shown the involvement of cannabinoid CB1 receptors in the mediation of capsaicin-induced inhibitory effects on LA-LTP ([23] Zschenderlein et al., 2011), it is reasonable to assume that the OLDA-induced enhancement of LA-LTP after the forced swim test can be attributed to the up-regulation of TRPV1 and the action of ligands such as anandamide on TRPV1.	Capsaicin	94-103	cannabinoid receptor 1 (brain)	Mus musculus	60-63
22982038-7	2013	Since we have recently shown the involvement of cannabinoid CB1 receptors in the mediation of capsaicin-induced inhibitory effects on LA-LTP ([23] Zschenderlein et al., 2011), it is reasonable to assume that the OLDA-induced enhancement of LA-LTP after the forced swim test can be attributed to the up-regulation of TRPV1 and the action of ligands such as anandamide on TRPV1.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	316-321
22982038-7	2013	Since we have recently shown the involvement of cannabinoid CB1 receptors in the mediation of capsaicin-induced inhibitory effects on LA-LTP ([23] Zschenderlein et al., 2011), it is reasonable to assume that the OLDA-induced enhancement of LA-LTP after the forced swim test can be attributed to the up-regulation of TRPV1 and the action of ligands such as anandamide on TRPV1.	Capsaicin	94-103	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	370-375
22691178-3	2013	Muscarinic and TRPV1 function was assessed by acetylcholine (5 mum) or capsaicin (0.5 mum) evoked ATP release, measured by luciferase assay.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
22691178-8	2013	The increase in capsaicin sensitivity correlated with increased urothelial TRPV1 expression.	Capsaicin	16-25	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-80
23013364-5	2013	We investigated the effect of CAP on ghrelin expression in testes of mice and on testosterone levels during pubertal and adult periods.	Capsaicin	30-33	ghrelin	Mus musculus	37-44
23155193-3	2013	METHODS: We examined the effect of NXN-188 on: (1) KCl-, capsaicin- and resiniferatoxin (RTX)-induced immunoreactive CGRP (iCGRP) release from isolated preparation of rat dura mater, trigeminal ganglion (TG) and trigeminal nucleus caudalis (TNC); and (2) capsaicin- and electrical stimulation (ES)-induced middle meningeal artery (MMA) dilation in a rat closed-cranial window.	Capsaicin	57-66	calcitonin-related polypeptide alpha	Rattus norvegicus	117-121
23956783-8	2013	Expression of TRPV1 in HuH-7 cells was confirmed by mRNA analysis as well as a test for increase of [Ca(2+)] i by TRPV1 agonist capsaicin and its inhibition by capsazepine.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
23781265-4	2013	Knockdown of growth arrest- and DNA damage-inducible gene 153 (GADD153), a marker of the endoplasmic-reticulum-stress- (ERS-) mediated apoptosis pathway, by specific siRNA attenuated capsaicin-induced apoptosis both in PANC-1 and SW1990 cells.	Capsaicin	183-192	DNA damage inducible transcript 3	Homo sapiens	13-61
23781265-4	2013	Knockdown of growth arrest- and DNA damage-inducible gene 153 (GADD153), a marker of the endoplasmic-reticulum-stress- (ERS-) mediated apoptosis pathway, by specific siRNA attenuated capsaicin-induced apoptosis both in PANC-1 and SW1990 cells.	Capsaicin	183-192	DNA damage inducible transcript 3	Homo sapiens	63-70
23781265-6	2013	Furthermore, capsaicin increased the expression of some key ERS markers, including glucose-regulated protein 78 (GRP78), phosphoprotein kinase-like endoplasmic reticulum kinase (phosphoPERK), and phosphoeukaryotic initiation factor-2 alpha (phospho-eIF2 alpha ), activating transcription factor 4 (ATF4) and GADD153 in tumor tissues.	Capsaicin	13-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	83-111
23781265-6	2013	Furthermore, capsaicin increased the expression of some key ERS markers, including glucose-regulated protein 78 (GRP78), phosphoprotein kinase-like endoplasmic reticulum kinase (phosphoPERK), and phosphoeukaryotic initiation factor-2 alpha (phospho-eIF2 alpha ), activating transcription factor 4 (ATF4) and GADD153 in tumor tissues.	Capsaicin	13-22	heat shock protein family A (Hsp70) member 5	Homo sapiens	113-118
23781265-6	2013	Furthermore, capsaicin increased the expression of some key ERS markers, including glucose-regulated protein 78 (GRP78), phosphoprotein kinase-like endoplasmic reticulum kinase (phosphoPERK), and phosphoeukaryotic initiation factor-2 alpha (phospho-eIF2 alpha ), activating transcription factor 4 (ATF4) and GADD153 in tumor tissues.	Capsaicin	13-22	eukaryotic translation initiation factor 2A	Homo sapiens	249-259
23781265-6	2013	Furthermore, capsaicin increased the expression of some key ERS markers, including glucose-regulated protein 78 (GRP78), phosphoprotein kinase-like endoplasmic reticulum kinase (phosphoPERK), and phosphoeukaryotic initiation factor-2 alpha (phospho-eIF2 alpha ), activating transcription factor 4 (ATF4) and GADD153 in tumor tissues.	Capsaicin	13-22	activating transcription factor 4	Homo sapiens	263-296
23781265-6	2013	Furthermore, capsaicin increased the expression of some key ERS markers, including glucose-regulated protein 78 (GRP78), phosphoprotein kinase-like endoplasmic reticulum kinase (phosphoPERK), and phosphoeukaryotic initiation factor-2 alpha (phospho-eIF2 alpha ), activating transcription factor 4 (ATF4) and GADD153 in tumor tissues.	Capsaicin	13-22	activating transcription factor 4	Homo sapiens	298-302
23781265-6	2013	Furthermore, capsaicin increased the expression of some key ERS markers, including glucose-regulated protein 78 (GRP78), phosphoprotein kinase-like endoplasmic reticulum kinase (phosphoPERK), and phosphoeukaryotic initiation factor-2 alpha (phospho-eIF2 alpha ), activating transcription factor 4 (ATF4) and GADD153 in tumor tissues.	Capsaicin	13-22	DNA damage inducible transcript 3	Homo sapiens	308-315
26752851-3	2013	Within the context of our hypothesis visceral nociception and nociceptor sensitization appear to be regulated by purinergic P2X3 and vanilloid TRPV1 receptors and 17beta-estradiol modulates DRG neuron response to ATP (P2X agonist) and capsaicin (TRPV1 agonist) suggesting that visceral afferent nociceptors are modulated by estrogen in the DRG.	Capsaicin	235-244	transient receptor potential cation channel subfamily V member 1	Homo sapiens	143-148
23956783-8	2013	Expression of TRPV1 in HuH-7 cells was confirmed by mRNA analysis as well as a test for increase of [Ca(2+)] i by TRPV1 agonist capsaicin and its inhibition by capsazepine.	Capsaicin	128-137	transient receptor potential cation channel subfamily V member 1	Homo sapiens	114-119
23128960-5	2013	Reduced tear secretion, corneal ulceration and leukocytic infiltration were found             in capsaicin (CAP)-treated rats, but this effect was significantly attenuated             by PEDF.	Capsaicin	97-106	serpin family F member 1	Rattus norvegicus	187-191
23128960-5	2013	Reduced tear secretion, corneal ulceration and leukocytic infiltration were found             in capsaicin (CAP)-treated rats, but this effect was significantly attenuated             by PEDF.	Capsaicin	108-111	serpin family F member 1	Rattus norvegicus	187-191
23199419-0	2013	Stimulation of cutaneous low threshold mechanoreceptors in mice after intracolonic capsaicin increases spinal c-Fos labeling in an NKCC1-dependent fashion.	Capsaicin	83-92	FBJ osteosarcoma oncogene	Mus musculus	110-115
24260973-4	2013	Challenge with inhaled capsaicin, an exogenous agonist of TRPV1, has been used to measure the sensitivity of the cough reflex.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
23525210-1	2013	BACKGROUND: It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors.	Capsaicin	168-177	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-122
23199419-0	2013	Stimulation of cutaneous low threshold mechanoreceptors in mice after intracolonic capsaicin increases spinal c-Fos labeling in an NKCC1-dependent fashion.	Capsaicin	83-92	solute carrier family 12, member 2	Mus musculus	131-136
23525210-1	2013	BACKGROUND: It has been demonstrated that N-ethyl-lidocaine (QX-314) can target the transient receptor protein vanilloid 1 (TRPV1) nociceptors when coadministered with capsaicin, resulting in a selective block of the nociceptors.	Capsaicin	168-177	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	124-129
23199419-2	2013	Accordingly, intracolonic capsaicin, which generates robust secondary (referred) allodynia on the abdomen of mice, also causes an increased spinal c-Fos labeling.	Capsaicin	26-35	FBJ osteosarcoma oncogene	Mus musculus	147-152
23525210-6	2013	The effects of menthol and capsaicin on the opening of TRPM8 and TRPV1 were also examined and compared with the potency of QX-314.	Capsaicin	27-36	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	55-60
23199419-6	2013	Here, we show that intracolonic capsaicin enhances spinal c-Fos labeling and secondary allodynia in an NKCC1-dependent manner.	Capsaicin	32-41	FBJ osteosarcoma oncogene	Mus musculus	58-63
23199419-6	2013	Here, we show that intracolonic capsaicin enhances spinal c-Fos labeling and secondary allodynia in an NKCC1-dependent manner.	Capsaicin	32-41	solute carrier family 12, member 2	Mus musculus	103-108
24162023-2	2013	TRPV1 is activated by multiple stimuli such as capsaicin, acid, and heat.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	0-5
23202294-8	2013	Notably, administration of the TRPV1 agonist capsaicin induced hypertrophy without overload and alleviated unloading- or denervation-induced atrophy.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
23581408-0	2013	Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways.	Capsaicin	18-27	AKT serine/threonine kinase 1	Homo sapiens	110-113
22935106-3	2013	Firstly, using Western blot analysis we found that epidermal growth factor receptor (EGFR) and TRPV1 were highly co-expressed in human bronchial epithelial cells (HBE16) with HNE and capsaicin co-treated, the levels of pro-inflammatory cytokines and MUC5AC were also highly co-expressed; however, TRPV1 receptor expression was low in these cells with only HNE stimulation, which demonstrated that sensitization of TRPV1 was not increased in HBE16 cells treated with HNE alone.	Capsaicin	183-192	epidermal growth factor receptor	Homo sapiens	51-83
22935106-3	2013	Firstly, using Western blot analysis we found that epidermal growth factor receptor (EGFR) and TRPV1 were highly co-expressed in human bronchial epithelial cells (HBE16) with HNE and capsaicin co-treated, the levels of pro-inflammatory cytokines and MUC5AC were also highly co-expressed; however, TRPV1 receptor expression was low in these cells with only HNE stimulation, which demonstrated that sensitization of TRPV1 was not increased in HBE16 cells treated with HNE alone.	Capsaicin	183-192	epidermal growth factor receptor	Homo sapiens	85-89
22935106-3	2013	Firstly, using Western blot analysis we found that epidermal growth factor receptor (EGFR) and TRPV1 were highly co-expressed in human bronchial epithelial cells (HBE16) with HNE and capsaicin co-treated, the levels of pro-inflammatory cytokines and MUC5AC were also highly co-expressed; however, TRPV1 receptor expression was low in these cells with only HNE stimulation, which demonstrated that sensitization of TRPV1 was not increased in HBE16 cells treated with HNE alone.	Capsaicin	183-192	transient receptor potential cation channel subfamily V member 1	Homo sapiens	95-100
23581408-0	2013	Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways.	Capsaicin	18-27	mechanistic target of rapamycin kinase	Homo sapiens	114-118
23920479-1	2013	BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO).	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-80
23581408-0	2013	Low-concentration capsaicin promotes colorectal cancer metastasis by triggering ROS production and modulating Akt/mTOR and STAT-3 pathways.	Capsaicin	18-27	signal transducer and activator of transcription 3	Homo sapiens	123-129
23581408-6	2013	Further, we showed that 100 microM capsaicin induced epithelial-to-mesenchymal (EMT), up-regulated expression of MMP-2 and MMP-9, and activated Akt/mTOR and STAT-3 pathways in SW480 cells.	Capsaicin	35-44	IL2 inducible T cell kinase	Homo sapiens	80-83
23581408-6	2013	Further, we showed that 100 microM capsaicin induced epithelial-to-mesenchymal (EMT), up-regulated expression of MMP-2 and MMP-9, and activated Akt/mTOR and STAT-3 pathways in SW480 cells.	Capsaicin	35-44	matrix metallopeptidase 2	Homo sapiens	113-118
23581408-6	2013	Further, we showed that 100 microM capsaicin induced epithelial-to-mesenchymal (EMT), up-regulated expression of MMP-2 and MMP-9, and activated Akt/mTOR and STAT-3 pathways in SW480 cells.	Capsaicin	35-44	matrix metallopeptidase 9	Homo sapiens	123-128
23581408-6	2013	Further, we showed that 100 microM capsaicin induced epithelial-to-mesenchymal (EMT), up-regulated expression of MMP-2 and MMP-9, and activated Akt/mTOR and STAT-3 pathways in SW480 cells.	Capsaicin	35-44	AKT serine/threonine kinase 1	Homo sapiens	144-147
23581408-6	2013	Further, we showed that 100 microM capsaicin induced epithelial-to-mesenchymal (EMT), up-regulated expression of MMP-2 and MMP-9, and activated Akt/mTOR and STAT-3 pathways in SW480 cells.	Capsaicin	35-44	mechanistic target of rapamycin kinase	Homo sapiens	148-152
23581408-6	2013	Further, we showed that 100 microM capsaicin induced epithelial-to-mesenchymal (EMT), up-regulated expression of MMP-2 and MMP-9, and activated Akt/mTOR and STAT-3 pathways in SW480 cells.	Capsaicin	35-44	signal transducer and activator of transcription 3	Homo sapiens	157-163
23255891-0	2013	Involvement of the phosphoinositide 3-kinase/Akt pathway in apoptosis induced by capsaicin in the human pancreatic cancer cell line PANC-1.	Capsaicin	81-90	AKT serine/threonine kinase 1	Homo sapiens	45-48
23255891-5	2013	Caspase-3 expression at both the protein and mRNA level was promoted following capsaicin treatment.	Capsaicin	79-88	caspase 3	Homo sapiens	0-9
23255891-6	2013	Furthermore, we revealed that phospho-PI3 Kinase p85 (Tyr458) and phospho-Akt (Ser473) in PANC-1 cells were downregulated in response to capsaicin.	Capsaicin	137-146	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	49-52
23255891-6	2013	Furthermore, we revealed that phospho-PI3 Kinase p85 (Tyr458) and phospho-Akt (Ser473) in PANC-1 cells were downregulated in response to capsaicin.	Capsaicin	137-146	AKT serine/threonine kinase 1	Homo sapiens	74-77
23255891-8	2013	An increased number of TUNEL-positive cells and cleaved caspase-3 were observed in capsaicin-treated mice.	Capsaicin	83-92	caspase 3	Mus musculus	56-65
23255891-9	2013	In vivo, capsaicin downregulated the expression of phospho-PI3 Kinase p85 (Tyr458) and phospho-Akt (Ser473).	Capsaicin	9-18	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	70-73
23255891-9	2013	In vivo, capsaicin downregulated the expression of phospho-PI3 Kinase p85 (Tyr458) and phospho-Akt (Ser473).	Capsaicin	9-18	AKT serine/threonine kinase 1	Homo sapiens	95-98
23255891-10	2013	In conclusion, we have demonstrated that capsaicin is an inhibitor of growth of PANC-1 cells, and downregulation of the phosphoinositide 3-kinase/Akt pathway may be involved in capsaicin-induced apoptosis in vitro and in vivo.	Capsaicin	177-186	AKT serine/threonine kinase 1	Homo sapiens	146-149
23920479-8	2013	CONCLUSION: We demonstrated for the first time that nNOS/NO is involved in gastric hyperemic responses to capsaicin.	Capsaicin	106-115	nitric oxide synthase 1	Rattus norvegicus	52-56
23920479-1	2013	BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO).	Capsaicin	92-101	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	82-87
23920479-1	2013	BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO).	Capsaicin	146-155	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	35-80
23920479-1	2013	BACKGROUND AND AIMS: Activation of transient receptor potential vanilloid type 1 (TRPV1) by capsaicin leads to gastric hyperemic response through capsaicin-sensitive sensory nerves and nitric oxide (NO).	Capsaicin	146-155	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	82-87
23920479-5	2013	RESULTS: The nNOS inhibitor N(5)-[imino(propylamino)methyl]-L-ornithine substantially reduced GMBF during capsaicin application, whereas the endothelial NOS (eNOS) inhibitor N(5)-(1-iminomethyl)-L-ornithine did not affect the effect of capsaicin during the application.	Capsaicin	106-115	nitric oxide synthase 1	Rattus norvegicus	13-17
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	84-89
23536811-1	2013	TRPV1 represents a non-selective cation channel activated by capsaicin, acidosis and high temperature.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
23536811-10	2013	Blocking the SR release (with ryanodine or dantrolene) led to a reduced capsaicin-induced Ca(2+) elevation suggesting that TRPV1 may participate to a secondary SR Ca(2+) liberation of greater amplitude.	Capsaicin	72-81	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	123-128
23468922-5	2013	Capsaicin was also shown to activate HSF-1.	Capsaicin	0-9	heat shock transcription factor 1	Homo sapiens	37-42
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein family A (Hsp70) member 4	Homo sapiens	169-174
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein 90 alpha family class A member 1	Homo sapiens	176-181
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein family B (small) member 1	Homo sapiens	186-191
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein family A (Hsp70) member 4	Homo sapiens	196-201
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein 90 alpha family class A member 1	Homo sapiens	206-211
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	236-241
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein family A (Hsp70) member 4	Homo sapiens	196-201
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein 90 alpha family class A member 1	Homo sapiens	206-211
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein family B (small) member 1	Homo sapiens	329-334
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein family A (Hsp70) member 4	Homo sapiens	196-201
23468922-4	2013	We found in various non-cancerous and cancerous mammalian epithelial cells that the TRPV1 agonists, capsaicin and resiniferatoxin (RTX), upregulated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70 and Hsp90 respectively, while the TRPV1 antagonists, capsazepine and AMG-9810, attenuated the accumulation of Hsp70, Hsp90 and Hsp27 and Hsp70, Hsp90, respectively.	Capsaicin	100-109	heat shock protein 90 alpha family class A member 1	Homo sapiens	206-211
22530568-0	2012	Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis.	Capsaicin	73-82	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	0-36
23372735-7	2013	The TRPV-1 agonist capsaicin (Cap) induced an increase of I(SC), which was similar to the I(SC) induced by FA.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-10
22905849-5	2012	The results demonstrated that capsaicin induced quiescent phenotype in GRX via PPARgamma activation.	Capsaicin	30-39	glutaredoxin	Homo sapiens	71-74
22905849-5	2012	The results demonstrated that capsaicin induced quiescent phenotype in GRX via PPARgamma activation.	Capsaicin	30-39	peroxisome proliferator activated receptor gamma	Homo sapiens	79-88
22762936-8	2012	Capsaicin, an agonist for the transient receptor potential cation channel subfamily V member 1 (TRPV1) warm-sensing channels, partially reversed this effect in 5 subjects.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	30-94
22762936-8	2012	Capsaicin, an agonist for the transient receptor potential cation channel subfamily V member 1 (TRPV1) warm-sensing channels, partially reversed this effect in 5 subjects.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-101
23034900-5	2012	Capsazepine, an inhibitor of TRPV1 (transient receptor potential vanilloid 1) channel, attenuated the pro-osteoclastogenic effect of 6-gingerol or capsaicin (an agonist of TRPV1).	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
23034900-5	2012	Capsazepine, an inhibitor of TRPV1 (transient receptor potential vanilloid 1) channel, attenuated the pro-osteoclastogenic effect of 6-gingerol or capsaicin (an agonist of TRPV1).	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	36-76
23034900-5	2012	Capsazepine, an inhibitor of TRPV1 (transient receptor potential vanilloid 1) channel, attenuated the pro-osteoclastogenic effect of 6-gingerol or capsaicin (an agonist of TRPV1).	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	172-177
22530568-9	2012	Tumors from capsaicin-treated mice showed reduced levels of Trx, increased phosphorylation of ASK1 at Thr845, and cleavage of caspase-3 and poly (ADP-ribose) polymerase.	Capsaicin	12-21	thioredoxin 1	Mus musculus	60-63
22530568-9	2012	Tumors from capsaicin-treated mice showed reduced levels of Trx, increased phosphorylation of ASK1 at Thr845, and cleavage of caspase-3 and poly (ADP-ribose) polymerase.	Capsaicin	12-21	mitogen-activated protein kinase kinase kinase 5	Mus musculus	94-98
22530568-9	2012	Tumors from capsaicin-treated mice showed reduced levels of Trx, increased phosphorylation of ASK1 at Thr845, and cleavage of caspase-3 and poly (ADP-ribose) polymerase.	Capsaicin	12-21	caspase 3	Mus musculus	126-168
22530568-0	2012	Apoptosis signal-regulating kinase 1-thioredoxin complex dissociation by capsaicin causes pancreatic tumor growth suppression by inducing apoptosis.	Capsaicin	73-82	thioredoxin	Homo sapiens	37-48
22530568-10	2012	INNOVATION: Our results for the first time demonstrated a new perspective that Trx-ASK1 complex can be targeted by capsaicin in pancreatic cancer.	Capsaicin	115-124	thioredoxin	Homo sapiens	79-82
22530568-10	2012	INNOVATION: Our results for the first time demonstrated a new perspective that Trx-ASK1 complex can be targeted by capsaicin in pancreatic cancer.	Capsaicin	115-124	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	83-87
22530568-1	2012	AIM: In this study, we evaluated the effect of capsaicin on the interaction of redox-sensitive thioredoxin (Trx)/apoptosis signal-regulating kinase 1 (ASK1) in pancreatic cancer cells.	Capsaicin	47-56	thioredoxin	Homo sapiens	95-106
22530568-11	2012	CONCLUSION: Capsaicin reduces Trx expression and dissociates Trx-ASK1 complex resulting in the activation of ASK1 and downstream effectors leading to apoptosis in pancreatic tumor cells in vitro and in vivo.	Capsaicin	12-21	thioredoxin	Homo sapiens	30-33
22530568-11	2012	CONCLUSION: Capsaicin reduces Trx expression and dissociates Trx-ASK1 complex resulting in the activation of ASK1 and downstream effectors leading to apoptosis in pancreatic tumor cells in vitro and in vivo.	Capsaicin	12-21	thioredoxin	Homo sapiens	61-64
22530568-1	2012	AIM: In this study, we evaluated the effect of capsaicin on the interaction of redox-sensitive thioredoxin (Trx)/apoptosis signal-regulating kinase 1 (ASK1) in pancreatic cancer cells.	Capsaicin	47-56	thioredoxin	Homo sapiens	108-111
22530568-11	2012	CONCLUSION: Capsaicin reduces Trx expression and dissociates Trx-ASK1 complex resulting in the activation of ASK1 and downstream effectors leading to apoptosis in pancreatic tumor cells in vitro and in vivo.	Capsaicin	12-21	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	65-69
22530568-1	2012	AIM: In this study, we evaluated the effect of capsaicin on the interaction of redox-sensitive thioredoxin (Trx)/apoptosis signal-regulating kinase 1 (ASK1) in pancreatic cancer cells.	Capsaicin	47-56	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	113-149
22530568-11	2012	CONCLUSION: Capsaicin reduces Trx expression and dissociates Trx-ASK1 complex resulting in the activation of ASK1 and downstream effectors leading to apoptosis in pancreatic tumor cells in vitro and in vivo.	Capsaicin	12-21	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	109-113
22530568-1	2012	AIM: In this study, we evaluated the effect of capsaicin on the interaction of redox-sensitive thioredoxin (Trx)/apoptosis signal-regulating kinase 1 (ASK1) in pancreatic cancer cells.	Capsaicin	47-56	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	151-155
22530568-2	2012	RESULTS: Capsaicin treatment downregulated Trx and increased the phosphorylation (activation) of ASK1 at Thr845 and kinase activity in AsPC-1 and BxPC-3 cells.	Capsaicin	9-18	thioredoxin	Homo sapiens	43-46
22530568-2	2012	RESULTS: Capsaicin treatment downregulated Trx and increased the phosphorylation (activation) of ASK1 at Thr845 and kinase activity in AsPC-1 and BxPC-3 cells.	Capsaicin	9-18	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	97-101
22530568-3	2012	Capsaicin treatment also activated downstream effector molecules MKK4/7, caspase-9, and caspase-3.	Capsaicin	0-9	mitogen-activated protein kinase kinase 4	Homo sapiens	65-69
22530568-3	2012	Capsaicin treatment also activated downstream effector molecules MKK4/7, caspase-9, and caspase-3.	Capsaicin	0-9	caspase 9	Homo sapiens	73-82
22530568-3	2012	Capsaicin treatment also activated downstream effector molecules MKK4/7, caspase-9, and caspase-3.	Capsaicin	0-9	caspase 3	Homo sapiens	88-97
22530568-4	2012	Antioxidants tiron or PEG-catalase blocked the activation of ASK1 cascade by capsaicin and protected the cells from apoptosis, indicating the involvement of reactive oxygen species in the activation of ASK1.	Capsaicin	77-86	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	61-65
22530568-4	2012	Antioxidants tiron or PEG-catalase blocked the activation of ASK1 cascade by capsaicin and protected the cells from apoptosis, indicating the involvement of reactive oxygen species in the activation of ASK1.	Capsaicin	77-86	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	202-206
22530568-5	2012	Our results further revealed that Trx overexpression suppressed the effects of capsaicin, whereas ASK1 overexpression enhanced the apoptosis-inducing effects of capsaicin.	Capsaicin	79-88	thioredoxin	Homo sapiens	34-37
22530568-5	2012	Our results further revealed that Trx overexpression suppressed the effects of capsaicin, whereas ASK1 overexpression enhanced the apoptosis-inducing effects of capsaicin.	Capsaicin	161-170	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	98-102
22530568-6	2012	beta-mercaptoethanol, a reducing agent, blocked capsaicin-mediated activation of ASK1, indicating that Trx-ASK1 complex exists and requires reducing conditions in the cell.	Capsaicin	48-57	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	81-85
22530568-6	2012	beta-mercaptoethanol, a reducing agent, blocked capsaicin-mediated activation of ASK1, indicating that Trx-ASK1 complex exists and requires reducing conditions in the cell.	Capsaicin	48-57	thioredoxin	Homo sapiens	103-106
22530568-6	2012	beta-mercaptoethanol, a reducing agent, blocked capsaicin-mediated activation of ASK1, indicating that Trx-ASK1 complex exists and requires reducing conditions in the cell.	Capsaicin	48-57	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	107-111
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	77-86	thioredoxin	Homo sapiens	23-26
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	77-86	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	95-99
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	77-86	thioredoxin	Homo sapiens	133-136
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	77-86	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	178-182
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	151-160	thioredoxin	Homo sapiens	23-26
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	151-160	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	95-99
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	151-160	thioredoxin	Homo sapiens	133-136
22530568-7	2012	On the other hand, the Trx inhibitor (1-chloro-2-4-dinitrobenzene) increased capsaicin-induced ASK1 kinase activity, suggesting that Trx inhibition by capsaicin is essential for ASK1 activation.	Capsaicin	151-160	mitogen-activated protein kinase kinase kinase 5	Homo sapiens	178-182
23162465-7	2012	Furthermore, the observed IL-6-mediated potentiation of secretory currents evoked by veratridine and capsaicin in SD rats was blunted in WKY rats.	Capsaicin	101-110	interleukin 6	Rattus norvegicus	26-30
22796104-1	2012	The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN).	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-114
22982418-1	2012	AIMS: TRPV1-expressing, capsaicin (CAP)-sensitive afferent fibers innervating bladder in addition to sensory function also exhibit "efferent" features consisting in TRPV1-dependent release of tachykinins (TAC) affecting detrusor smooth muscle (DSM) contractions.	Capsaicin	35-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	6-11
22982418-1	2012	AIMS: TRPV1-expressing, capsaicin (CAP)-sensitive afferent fibers innervating bladder in addition to sensory function also exhibit "efferent" features consisting in TRPV1-dependent release of tachykinins (TAC) affecting detrusor smooth muscle (DSM) contractions.	Capsaicin	35-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	165-170
22796104-1	2012	The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN).	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	116-121
22796104-1	2012	The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN).	Capsaicin	46-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	66-114
22796104-1	2012	The present study examined whether capsaicin (CAP), an agonist of transient receptor potential vanilloid subtype 1 (TRPV1) can prevent 1-methyl-4-phenylpyridinium (MPP(+))-induced dopaminergic (DA) neuronal death in the substantia nigra (SN).	Capsaicin	46-49	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	116-121
22943972-6	2012	Due to Glu insults, the reduced mRNA levels of cytoplasmic glutathione peroxidase, copper/zinc and manganese superoxide dismutases, and Bcl-x(L) and the overexpressed mRNA levels of interleukin-1beta and tumor necrosis factor-alpha were significantly restored by post-treatment of capsaicin and/or resveratrol.	Capsaicin	281-290	interleukin 1 beta	Mus musculus	182-231
23033372-9	2012	WAT injection of capsaicin increased plasma renin, angiotensin II, and norepinephrine levels in OH and caused more c-fos expression in paraventricular nucleus in OH than ON and in ON than obesity-resistant or control rats.	Capsaicin	17-26	renin	Rattus norvegicus	44-49
23033372-9	2012	WAT injection of capsaicin increased plasma renin, angiotensin II, and norepinephrine levels in OH and caused more c-fos expression in paraventricular nucleus in OH than ON and in ON than obesity-resistant or control rats.	Capsaicin	17-26	angiotensinogen	Rattus norvegicus	51-65
23033372-9	2012	WAT injection of capsaicin increased plasma renin, angiotensin II, and norepinephrine levels in OH and caused more c-fos expression in paraventricular nucleus in OH than ON and in ON than obesity-resistant or control rats.	Capsaicin	17-26	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	115-120
23109716-11	2012	In electrophysiology studies, mutation of the Ca(2+)-CaM-binding site on TRPV1-ARD abolished desensitization in response to repeated application of capsaicin, whereas mutation of the Ca(2+)-CaM-binding site in TRPV1-CT led to a more subtle phenotype of slowed and reduced TRPV1 desensitization.	Capsaicin	148-157	calmodulin 3	Homo sapiens	46-56
22820944-9	2012	In peripheral sensory neurons high concentrations of pitolisant (30-500 muM), but not ciproxifan, partially inhibited calcium increases induced by capsaicin, a selective activator of transient receptor potential vanilloid receptor 1 (TRPV1).	Capsaicin	147-156	transient receptor potential cation channel subfamily V member 1	Homo sapiens	183-232
22820944-9	2012	In peripheral sensory neurons high concentrations of pitolisant (30-500 muM), but not ciproxifan, partially inhibited calcium increases induced by capsaicin, a selective activator of transient receptor potential vanilloid receptor 1 (TRPV1).	Capsaicin	147-156	transient receptor potential cation channel subfamily V member 1	Homo sapiens	234-239
23109716-11	2012	In electrophysiology studies, mutation of the Ca(2+)-CaM-binding site on TRPV1-ARD abolished desensitization in response to repeated application of capsaicin, whereas mutation of the Ca(2+)-CaM-binding site in TRPV1-CT led to a more subtle phenotype of slowed and reduced TRPV1 desensitization.	Capsaicin	148-157	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
23401958-4	2012	Administration of capsaicin modified age-related changes in the number of CGRP-immunopositive neurons.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	74-78
22528458-1	2012	Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	174-214
22528458-1	2012	Pretreatment with the ultrapotent capsaicin analog resiniferatoxin (RTX) has been applied as a selective pharmacological tool in inflammation and pain studies to desensitize transient receptor potential vanilloid 1 (TRPV1) receptor-expressing sensory nerve endings.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	216-221
22896717-10	2012	A similar reduction in the response of Trpm1(+/tvrm27) DBCs to LY341495 or capsaicin is evident in whole cell recordings.	Capsaicin	75-84	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	39-44
22902197-2	2012	TRPV1 channels located on peripheral neurons mainly transduce the sense of heat and are also activated by low pH or capsaicin.	Capsaicin	116-125	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
22841658-8	2012	Thus, intrathecal (C(1)-C(3)) dihydroergotamine seems to inhibit the external carotid vasodilatation to capsaicin by spinal activation of serotonin 5-HT(1B/1D) (probably 5-HT(1B)) receptors and alpha(2) (probably alpha(2A/2C))-adrenoceptors.	Capsaicin	104-113	5-hydroxytryptamine receptor 1B	Canis lupus familiaris	148-155
22952227-5	2012	Moreover, siRNA-mediated knockdown of beta-arrestin-2 in primary cultures resulted in a significant increase in both initial and repeated responses to capsaicin.	Capsaicin	151-160	arrestin, beta 2	Mus musculus	38-53
23015437-5	2012	Whole-cell voltage-clamp recordings revealed that, in Gu-I, capsaicin-induced currents in layer 3 (L3) pyramidal cells (PCs) displayed no apparent desensitization, while those in layer 5 (L5) PCs displayed Ca(2+)-dependent desensitization, suggesting that L3 and L5 PCs respond differentially to TRPV1 activation.	Capsaicin	60-69	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	296-301
22750259-1	2012	OBJECTIVE: Lafutidine, an antagonist of histamine H2-receptor, has gastroprotective activity associated with activation of capsaicin-mediated sensory nerves.	Capsaicin	123-132	histamine receptor H2	Homo sapiens	40-61
22819536-0	2012	Sex differences in serotonin enhancement of capsaicin-evoked calcitonin gene-related peptide release from human dental pulp.	Capsaicin	44-53	calcitonin related polypeptide alpha	Homo sapiens	61-92
22819536-8	2012	CGRP release was then stimulated with the TRPV1 agonist capsaicin 1mumol/L and quantitated by enzyme immunoassay.	Capsaicin	56-65	calcitonin related polypeptide alpha	Homo sapiens	0-4
22819536-8	2012	CGRP release was then stimulated with the TRPV1 agonist capsaicin 1mumol/L and quantitated by enzyme immunoassay.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
22819536-10	2012	We report that 5HT induced a significant increase in capsaicin-evoked CGRP release, and that this enhancement was observed only in female dental pulp, with no effect of 5HT on male dental pulp.	Capsaicin	53-62	calcitonin related polypeptide alpha	Homo sapiens	70-74
22819536-12	2012	These results indicate that 5HT enhances capsaicin-evoked CGRP release from human trigeminal nociceptors in a sexually dimorphic manner providing a mechanistic basis for prevalence of trigeminal pain disorders in women.	Capsaicin	41-50	calcitonin related polypeptide alpha	Homo sapiens	58-62
22205399-4	2012	By current clamp recording, we found that the excitability of capsaicin-sensitive small and medium trigeminal ganglion (TG) neurons was significantly reduced by a CaM specific antagonist (W-7) and a CaMKII antagonist (KN-93).	Capsaicin	62-71	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	199-205
22205399-8	2012	Those evidences show that the excitability of capsaicin sensitive small and medium TG neurons can be regulated by Ca(2+)-CaM-CaMKII pathway through modulating VGSCs and VGPCs.	Capsaicin	46-55	calcium/calmodulin dependent protein kinase II gamma	Homo sapiens	125-131
23023032-2	2012	Understanding the actions of capsaicin led to the discovery its receptor, transient receptor potential (TRP) vanilloid subfamily member 1 (TRPV1), part of the superfamily of TRP receptors, sensing external events.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	139-144
22858856-1	2012	Transient receptor potential vanilloid 1 (TRPV1) is a highly polymodal TRP channel activated by various stimuli, including capsaicin, heat and acids.	Capsaicin	123-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-40
22998799-5	2012	We previously identified MRS1477, a 1,4-dihydropyridine that potentiates vanilloid and pH activation of TRPV1 in vitro, but displays no detectable intrinsic agonist activity of its own.	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	104-109
22998799-10	2012	However, rats treated with the combination of capsaicin and MRS1477 exhibited increased withdrawal latency and decreased response intensity consistent with agonist potentiation and inactivation or lesion of TRPV1-containing nerve terminals.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	207-212
22617702-5	2012	The present study examined the roles of group III mGluRs and their subtype 7 and 8 receptors (mGluR7 and mGluR8) in modulating the cardiac-somatic reflex induced by pericardial capsaicin, which was monitored by recording electromyogram (EMG) activity from the spinotrapezius muscle in anesthetized rats.	Capsaicin	177-186	glutamate receptor, ionotropic, kainate 3	Mus musculus	94-100
22617702-5	2012	The present study examined the roles of group III mGluRs and their subtype 7 and 8 receptors (mGluR7 and mGluR8) in modulating the cardiac-somatic reflex induced by pericardial capsaicin, which was monitored by recording electromyogram (EMG) activity from the spinotrapezius muscle in anesthetized rats.	Capsaicin	177-186	glutamate receptor, metabotropic 8	Mus musculus	105-111
22790593-8	2012	In HET-1A cells, the TRPV1 agonist capsaicin reproduced these findings for mRNA of the inflammatory mediators lyso-PAF AT, IL-8, and eotaxin-1.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	21-26
22790593-8	2012	In HET-1A cells, the TRPV1 agonist capsaicin reproduced these findings for mRNA of the inflammatory mediators lyso-PAF AT, IL-8, and eotaxin-1.	Capsaicin	35-44	lysophosphatidylcholine acyltransferase 1	Homo sapiens	110-121
22790593-8	2012	In HET-1A cells, the TRPV1 agonist capsaicin reproduced these findings for mRNA of the inflammatory mediators lyso-PAF AT, IL-8, and eotaxin-1.	Capsaicin	35-44	C-X-C motif chemokine ligand 8	Homo sapiens	123-127
22790593-8	2012	In HET-1A cells, the TRPV1 agonist capsaicin reproduced these findings for mRNA of the inflammatory mediators lyso-PAF AT, IL-8, and eotaxin-1.	Capsaicin	35-44	C-C motif chemokine ligand 11	Homo sapiens	133-142
22858856-1	2012	Transient receptor potential vanilloid 1 (TRPV1) is a highly polymodal TRP channel activated by various stimuli, including capsaicin, heat and acids.	Capsaicin	123-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	42-47
22634607-7	2012	Systemic administration of the non-pungent capsaicinoid, palvanil, produces, at least in mice, much less of those side effects typical of TRPV1 agonists (hypothermia and bronchoconstriction), whilst being very effective at reducing pain and oedema.	Capsaicin	43-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	138-143
22949588-3	2012	The TdT-mediated dUTP-biotin nick end-labeling (TUNEL) method demonstrated that both capsaicin and curcumin induced apoptosis, with the apoptotic effect of capsaicin appearing at an early stage of application.	Capsaicin	85-94	deoxynucleotidyltransferase, terminal	Mus musculus	4-7
22949588-3	2012	The TdT-mediated dUTP-biotin nick end-labeling (TUNEL) method demonstrated that both capsaicin and curcumin induced apoptosis, with the apoptotic effect of capsaicin appearing at an early stage of application.	Capsaicin	156-165	deoxynucleotidyltransferase, terminal	Mus musculus	4-7
22933780-7	2012	Application of CNP potentiated capsaicin- and proton-activated TRPV1 currents in cultured mouse DRG neurons and increased their firing frequency, an effect that was absent in DRG neurons from TRPV1(-/-) mice.	Capsaicin	31-40	natriuretic peptide type C	Mus musculus	15-18
22820913-6	2012	Using microspectrofluorimetry (indo-1), we show that capsaicin and 4alpha-phorbol-12,13-didecanoate (4alpha-PDD), selective agonists of TRPV1 and TRPV4, respectively, increased the intracellular calcium concentration of PASMC.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-141
22820913-6	2012	Using microspectrofluorimetry (indo-1), we show that capsaicin and 4alpha-phorbol-12,13-didecanoate (4alpha-PDD), selective agonists of TRPV1 and TRPV4, respectively, increased the intracellular calcium concentration of PASMC.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	146-151
22641083-6	2012	Chemical stimulation by saccharin or capsaicin at the weaning stage also increased SNAP25 immunoreactivity in the insular or somatosensory cortical area, respectively.	Capsaicin	37-46	synaptosomal-associated protein 25	Mus musculus	83-89
22820913-9	2012	Capsaicin- and 4alpha-PDD-induced calcium and migratory responses were inhibited by the selective TRPV1 and TRPV4 blockers, capsazepine and HC067047, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
22820913-9	2012	Capsaicin- and 4alpha-PDD-induced calcium and migratory responses were inhibited by the selective TRPV1 and TRPV4 blockers, capsazepine and HC067047, respectively.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 4	Rattus norvegicus	108-113
22659492-5	2012	Pretreatment with BTX-A inhibited BCAO- or capsaicin-induced increases in expression of SNAP-25, substance P, and ROS in a dose-dependent manner in brainstem and lung tissue.	Capsaicin	43-52	synaptosome associated protein 25	Rattus norvegicus	88-95
22929055-5	2012	Interestingly, the bladder"s sensitivity to noxious chemicals has been used successfully in clinical practice, by intravesically infusing the TRPV1 agonist capsaicin to treat neurogenic bladder overactivity.	Capsaicin	156-165	transient receptor potential cation channel subfamily V member 1	Homo sapiens	142-147
23293745-8	2012	Capsaicin treatment restored the gastric resistance and blood flow responses to topical application of ethanol in BDL rats and ET-1 and -3 production to levels observed in controls.	Capsaicin	0-9	endothelin 1	Rattus norvegicus	127-138
22870919-7	2012	RESULTS: Pretreatment of CCL2 for 24 to 36 hours dose-dependently (EC(50) value = 0.6 +- 0.05 nM) increased the density of capsaicin-induced currents in small putative DRG nociceptive neurons.	Capsaicin	123-132	C-C motif chemokine ligand 2	Rattus norvegicus	25-29
22588258-4	2012	JTS-653 competitively antagonized the capsaicin-induced activation of human TRPV1 with pA(2) values of 10.1.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	76-81
22721614-1	2012	Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP).	Capsaicin	97-106	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	14-52
22721614-1	2012	Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP).	Capsaicin	97-106	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	54-59
22721614-1	2012	Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP).	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	78-83
22721614-1	2012	Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP).	Capsaicin	97-106	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	189-220
22721614-1	2012	Activation of transient receptor potential ankyrin 1 (TRPA1) and vanilloid 1 (TRPV1) channels on capsaicin-sensitive sensory neurons causes release of inflammatory neuropeptides, including calcitonin gene-related peptide (CGRP).	Capsaicin	97-106	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	222-226
22664955-3	2012	We tested the hypothesis that dietary capsaicin regulates glucose homeostasis through the activation of transient receptor potential vanilloid 1 (TRPV1)-mediated glucagon-like peptide-1 (GLP-1) secretion in the intestinal cells and tissues.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	104-144
22664955-3	2012	We tested the hypothesis that dietary capsaicin regulates glucose homeostasis through the activation of transient receptor potential vanilloid 1 (TRPV1)-mediated glucagon-like peptide-1 (GLP-1) secretion in the intestinal cells and tissues.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	146-151
22664955-3	2012	We tested the hypothesis that dietary capsaicin regulates glucose homeostasis through the activation of transient receptor potential vanilloid 1 (TRPV1)-mediated glucagon-like peptide-1 (GLP-1) secretion in the intestinal cells and tissues.	Capsaicin	38-47	glucagon	Mus musculus	162-185
22664955-3	2012	We tested the hypothesis that dietary capsaicin regulates glucose homeostasis through the activation of transient receptor potential vanilloid 1 (TRPV1)-mediated glucagon-like peptide-1 (GLP-1) secretion in the intestinal cells and tissues.	Capsaicin	38-47	glucagon	Mus musculus	187-192
22664955-6	2012	Capsaicin stimulated GLP-1 secretion from STC-1 cells in a calcium-dependent manner through TRPV1 activation.	Capsaicin	0-9	glucagon	Mus musculus	21-26
22664955-6	2012	Capsaicin stimulated GLP-1 secretion from STC-1 cells in a calcium-dependent manner through TRPV1 activation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	92-97
22664955-7	2012	Acute capsaicin administration by gastric gavage increased GLP-1 and insulin secretion in vivo in WT but not in TRPV1(-/-) mice.	Capsaicin	6-15	glucagon	Mus musculus	59-64
22664955-8	2012	Furthermore, chronic dietary capsaicin not only improved glucose tolerance and increased insulin levels but also lowered daily blood glucose profiles and increased plasma GLP-1 levels in WT mice.	Capsaicin	29-38	glucagon	Mus musculus	171-176
22664955-10	2012	In db/db mice, TRPV1 activation by dietary capsaicin ameliorated abnormal glucose homeostasis and increased GLP-1 levels in the plasma and ileum.	Capsaicin	43-52	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	15-20
22664955-10	2012	In db/db mice, TRPV1 activation by dietary capsaicin ameliorated abnormal glucose homeostasis and increased GLP-1 levels in the plasma and ileum.	Capsaicin	43-52	glucagon	Mus musculus	108-113
22566669-4	2012	BCTP is a classic polymodal inhibitor of TRPV1, blocking activation of the human channel by capsaicin and low pH with IC(50) values of 65.4 and 26.4 nM, respectively.	Capsaicin	92-101	transient receptor potential cation channel subfamily V member 1	Homo sapiens	41-46
22570364-5	2012	Although both classes of antagonists completely blocked capsaicin- and NADA-induced activation of TRPV1, select compounds only partially inhibited activation of the channel by protons.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-103
22610171-5	2012	Capsaicin (1-100 mug kg(-1) min(-1)) dose dependently increased coronary blood flow in control mice, which was inhibited by the TRPV1 antagonist capsazepine or the nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine methyl ester (L-NAME).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	128-133
22498929-5	2012	This augmented activity by capsaicin was more prominent at one day (DSS-1) than at 8 day (DSS-8) after the administration of DSS.	Capsaicin	27-36	SEM1 26S proteasome subunit	Rattus norvegicus	68-73
22498929-6	2012	The increased nerve activity caused by capsaicin in DSS-1 and DSS-8 was significantly inhibited by pretreatment with ruthenium red, which is a nonselective inhibitor of TRP channels of unmyelinated C-fibers (nociceptors).	Capsaicin	39-48	SEM1 26S proteasome subunit	Rattus norvegicus	52-57
22749994-2	2012	Capsaicin and lowered extracellular pH from 7.4 to 5.5 induce cell death through TRPV1-mediated Ca(2+) entry and reactive oxygen species (ROS) production.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	81-86
22749994-6	2012	We found that the moderate extracellular acidification (from pH 7.4 to 6.8) inhibited the capsaicin-induced Ca(2+) entry through attenuating the activity of TRPV1.	Capsaicin	90-99	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	157-162
22610171-5	2012	Capsaicin (1-100 mug kg(-1) min(-1)) dose dependently increased coronary blood flow in control mice, which was inhibited by the TRPV1 antagonist capsazepine or the nitric oxide synthase (NOS) inhibitor N-nitro-l-arginine methyl ester (L-NAME).	Capsaicin	0-9	nitric oxide synthase 1, neuronal	Mus musculus	164-185
22610171-8	2012	Vasoreactivity studies in isolated pressurized mouse coronary microvessels revealed a capsaicin-dependent relaxation that was inhibited by the TRPV1 inhibitor SB366791 l-NAME and to the large conductance calcium-sensitive potassium channel (BK) inhibitors iberiotoxin and Penetrim A.	Capsaicin	86-95	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	143-148
22776418-7	2012	RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-143
22641053-6	2012	Bv8- or capsaicin-stimulated CGRP release was markedly enhanced in tissues taken from Bv8-pretreated mice during the late, but not the early, phase of hyperalgesia.	Capsaicin	8-17	calcitonin-related polypeptide alpha	Rattus norvegicus	29-33
22776418-7	2012	RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	145-150
22776418-7	2012	RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals.	Capsaicin	207-216	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	98-143
22776418-7	2012	RESULTS: Postnatal capsaicin treatment, which has been shown to denervate the C-fibers expressing transient receptor potential vanilloid type-1 (TRPV1) channels, completely abolished eye-wiping responses to capsaicin eye instillation in rats, but this treatment did not affect mechanical allodynia in the nerve-ligated animals.	Capsaicin	207-216	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	145-150
22776418-8	2012	However, the postnatal capsaicin treatment prevented LPB-CeC synaptic potentiation after SNL, unlike in the vehicle-treated rats, primarily due to the decreased incidence of potentiated transmission by elimination of TRPV1-expressing C-fiber afferents.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	217-222
22724881-1	2012	BACKGROUND: The transient receptor potential vanilloid receptor 1, TRPV1 [previously termed the capsaicin or vanilloid receptor 1 (VR1)] is a nonselective cation channel that has been cloned and is expressed predominantly in sensory neurons.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-65
23240446-5	2012	Modulation of the activity of these fibers and/or TRPV1 receptors by a number of substances (such as capsaicin, lidocaine, etc.)	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	50-55
22724881-1	2012	BACKGROUND: The transient receptor potential vanilloid receptor 1, TRPV1 [previously termed the capsaicin or vanilloid receptor 1 (VR1)] is a nonselective cation channel that has been cloned and is expressed predominantly in sensory neurons.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	67-72
22327653-2	2012	The rabbit model is considered excellent for studying cardiovascular and metabolic diseases, however, the tissue expression of TRPV1 and physiological functions of its ligand capsaicin on diet-induced obesity have not been fully defined in this model.	Capsaicin	175-184	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	127-132
22724881-1	2012	BACKGROUND: The transient receptor potential vanilloid receptor 1, TRPV1 [previously termed the capsaicin or vanilloid receptor 1 (VR1)] is a nonselective cation channel that has been cloned and is expressed predominantly in sensory neurons.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	109-129
22724881-1	2012	BACKGROUND: The transient receptor potential vanilloid receptor 1, TRPV1 [previously termed the capsaicin or vanilloid receptor 1 (VR1)] is a nonselective cation channel that has been cloned and is expressed predominantly in sensory neurons.	Capsaicin	96-105	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	131-134
22724881-2	2012	TRPV1 is activated by protons as well as capsaicin.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22724881-4	2012	We have examined the effect of the selective TRPV1-receptor ligand, capsaicin, on intestinal peristalsis by studying migrating motor complexes (MMCs).	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-50
22724881-8	2012	RESULTS: Capsaicin (1 - 100 nM) caused a dose-dependent inhibition of motility manifested as an increase in the interval between motor complexes (MCs) in the WT animal only, a response abolished by pre-treatment with TRPV1 antagonist capsazepine (Capz), ruthenium red (RR), and L-NAME.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	217-222
22462738-11	2012	Furthermore, capsaicin inhibits the proliferation of 5637 bladder carcinoma cells by cycle arrest with the inhibition of CDK2, CDK4 and CDK6.	Capsaicin	13-22	cyclin dependent kinase 2	Homo sapiens	121-125
22462738-11	2012	Furthermore, capsaicin inhibits the proliferation of 5637 bladder carcinoma cells by cycle arrest with the inhibition of CDK2, CDK4 and CDK6.	Capsaicin	13-22	cyclin dependent kinase 4	Homo sapiens	127-131
22462738-11	2012	Furthermore, capsaicin inhibits the proliferation of 5637 bladder carcinoma cells by cycle arrest with the inhibition of CDK2, CDK4 and CDK6.	Capsaicin	13-22	cyclin dependent kinase 6	Homo sapiens	136-140
22492938-7	2012	Capsaicin (200 muM) was delivered via dosimeter and one-way (inspiratory) valve attached to a side port between the facemask and pneumotachograph.	Capsaicin	0-9	latexin	Homo sapiens	15-18
22492938-9	2012	All participants coughed in response to 200 muM capsaicin and were able to modify the cough.	Capsaicin	48-57	latexin	Homo sapiens	44-47
22327653-8	2012	We conclude that the intake of capsaicin can prevent diet-induced obesity and rabbit model is useful for the study of TRPV1 function in cardiovascular and metabolic diseases.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	118-123
22665354-5	2012	The observed increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels following capsaicin treatment indicated that the apoptotic response was mitochondrial pathway-dependent.	Capsaicin	105-114	cytochrome c, somatic	Homo sapiens	35-47
22665354-5	2012	The observed increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels following capsaicin treatment indicated that the apoptotic response was mitochondrial pathway-dependent.	Capsaicin	105-114	caspase 3	Homo sapiens	63-72
22665354-5	2012	The observed increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels following capsaicin treatment indicated that the apoptotic response was mitochondrial pathway-dependent.	Capsaicin	105-114	collagen type XI alpha 2 chain	Homo sapiens	77-81
22665354-5	2012	The observed increase in cytosolic cytochrome c, activation of caspase 3 and PARP (p85) levels following capsaicin treatment indicated that the apoptotic response was mitochondrial pathway-dependent.	Capsaicin	105-114	phosphoinositide-3-kinase regulatory subunit 2	Homo sapiens	83-86
22665354-7	2012	Furthermore, capsaicin suppressed the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.	Capsaicin	13-22	cyclin B1	Homo sapiens	143-159
22665354-7	2012	Furthermore, capsaicin suppressed the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.	Capsaicin	13-22	cyclin dependent kinase 1	Homo sapiens	205-210
22665354-7	2012	Furthermore, capsaicin suppressed the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.	Capsaicin	13-22	cyclin dependent kinase 2	Homo sapiens	212-217
22665354-7	2012	Furthermore, capsaicin suppressed the cell cycle progression at the G1/S phase in FaDu cells by decreasing the expression of the regulators of cyclin B1 and D1, as well as cyclin-dependent protein kinases cdk-1, cdk-2 and cdk-4.	Capsaicin	13-22	cyclin dependent kinase 4	Homo sapiens	222-227
22570472-3	2012	We report that TRPV1 is N-glycosylated and that N-glycosylation is a major determinant of capsaicin-evoked desensitization and ionic permeability.	Capsaicin	90-99	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
22570472-7	2012	Capsaicin-evoked increases in intracellular calcium ([Ca(2+)](i)) were sustained in wild-type TRPV1 HEK-293 cells but were rapidly desensitized in N604T TRPV1 cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	94-99
22570472-7	2012	Capsaicin-evoked increases in intracellular calcium ([Ca(2+)](i)) were sustained in wild-type TRPV1 HEK-293 cells but were rapidly desensitized in N604T TRPV1 cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	153-158
22570472-10	2012	Capsaicin evoked a marked, concentration-dependent increase in uptake of the large cationic dye YO-PRO-1 in cells expressing wild-type TRPV1, indicative of loss of ion selectivity, that was completely absent in cells expressing N604T TRPV1.	Capsaicin	0-9	lamin A/C	Homo sapiens	99-104
22570472-10	2012	Capsaicin evoked a marked, concentration-dependent increase in uptake of the large cationic dye YO-PRO-1 in cells expressing wild-type TRPV1, indicative of loss of ion selectivity, that was completely absent in cells expressing N604T TRPV1.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	135-140
22570472-10	2012	Capsaicin evoked a marked, concentration-dependent increase in uptake of the large cationic dye YO-PRO-1 in cells expressing wild-type TRPV1, indicative of loss of ion selectivity, that was completely absent in cells expressing N604T TRPV1.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	234-239
22570472-11	2012	Thus, TRPV1 is variably N-glycosylated and glycosylation is a key determinant of capsaicin regulation of TRPV1 desensitization and permeability.	Capsaicin	81-90	transient receptor potential cation channel subfamily V member 1	Homo sapiens	6-11
22570472-11	2012	Thus, TRPV1 is variably N-glycosylated and glycosylation is a key determinant of capsaicin regulation of TRPV1 desensitization and permeability.	Capsaicin	81-90	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-110
22681758-11	2012	CCK-8 receptor antagonist CR-1409 or perivagal application of capsaicin abolished the effect of CCK on aversive visceral pain memory, which was consistent with the notion that vagal afferent modulates affective aspects of visceral pain.	Capsaicin	62-71	cholecystokinin	Rattus norvegicus	96-99
22713358-6	2012	Immunoblotting analysis indicates that both Wnt3a a beta-catenin are up-regulated in the SCDH of various mouse pain models created by hind-paw injection of capsaicin, intrathecal (i.t.)	Capsaicin	156-165	wingless-type MMTV integration site family, member 3A	Mus musculus	44-49
22713358-6	2012	Immunoblotting analysis indicates that both Wnt3a a beta-catenin are up-regulated in the SCDH of various mouse pain models created by hind-paw injection of capsaicin, intrathecal (i.t.)	Capsaicin	156-165	catenin (cadherin associated protein), beta 1	Mus musculus	52-64
22542657-8	2012	attenuated the effects of capsaicin and capsazepine, demonstrating a probable interplay between serotonin and TRPV1, at least in parts.	Capsaicin	26-35	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	110-115
22562048-4	2012	Here, we stimulated TRPV1 in the trigeminal afferents by a repetitive injection of 10 mmol/l capsaicin into the whisker pad for 2 days (d2 group), 4 days (d4 group), or 6 days (d6 group).	Capsaicin	93-102	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
22581043-2	2012	Our previous data strongly suggest an interaction between ERs and ATP-induced purinergic (P2X3) as well as ERs and capsaicin-induced vanilloid (TRPV1) receptors at the level of dorsal root ganglion (DRG) neurons.	Capsaicin	115-124	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	144-149
22233274-9	2012	In capsaicin-induced synovitis, the increased endothelial cell proliferation index was partially blocked by administration of NK1 or CGRP antagonists individually and was reduced to the level of saline controls by coadministration of both receptor antagonists.	Capsaicin	3-12	calcitonin-related polypeptide alpha	Rattus norvegicus	133-137
22476973-8	2012	For methyl salicylate and capsaicin, drug diffusion in the PSA matrices is the main factor controlled by the release kinetic constant k. The high [SI] diblock content and high plasticizer amount in matrix provide the PSA with a homogeneous and soften microstructure, resulting in a high diffusion rate.	Capsaicin	26-35	aminopeptidase puromycin sensitive	Homo sapiens	59-62
22476973-8	2012	For methyl salicylate and capsaicin, drug diffusion in the PSA matrices is the main factor controlled by the release kinetic constant k. The high [SI] diblock content and high plasticizer amount in matrix provide the PSA with a homogeneous and soften microstructure, resulting in a high diffusion rate.	Capsaicin	26-35	aminopeptidase puromycin sensitive	Homo sapiens	217-220
22233274-11	2012	Capsaicin-induced endothelial cell proliferation was completely blocked by coadministration of CGRP and NK1 receptor antagonists, indicating that both CGRP and substance P may contribute to angiogenesis in this model of synovitis.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	95-99
22233274-1	2012	BACKGROUND AND PURPOSE: We have tested the hypothesis that calcitonin gene-related peptide (CGRP) is a mediator of capsaicin-induced angiogenesis in vivo.	Capsaicin	115-124	calcitonin-related polypeptide alpha	Rattus norvegicus	59-90
22233274-1	2012	BACKGROUND AND PURPOSE: We have tested the hypothesis that calcitonin gene-related peptide (CGRP) is a mediator of capsaicin-induced angiogenesis in vivo.	Capsaicin	115-124	calcitonin-related polypeptide alpha	Rattus norvegicus	92-96
22233274-11	2012	Capsaicin-induced endothelial cell proliferation was completely blocked by coadministration of CGRP and NK1 receptor antagonists, indicating that both CGRP and substance P may contribute to angiogenesis in this model of synovitis.	Capsaicin	0-9	tachykinin receptor 1	Rattus norvegicus	104-116
22233274-11	2012	Capsaicin-induced endothelial cell proliferation was completely blocked by coadministration of CGRP and NK1 receptor antagonists, indicating that both CGRP and substance P may contribute to angiogenesis in this model of synovitis.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	151-155
22386872-7	2012	Moreover, mice treated with capsaicin, a TRPV1 agonist (10, or 100mug/mouse) exhibited pro-convulsant activity that was blocked by capsazepine pretreatment.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	41-46
22508518-6	2012	CCK-evoked phospho-ERK1/2 in the NTS was attenuated in rats pretreated with capsaicin and was abolished by systemic injection of a CCK1 receptor antagonist, indicating that phosphorylation of ERK1/2 occurs in and is mediated by gastrointestinal vagal afferents.	Capsaicin	76-85	cholecystokinin	Rattus norvegicus	0-3
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
22508518-6	2012	CCK-evoked phospho-ERK1/2 in the NTS was attenuated in rats pretreated with capsaicin and was abolished by systemic injection of a CCK1 receptor antagonist, indicating that phosphorylation of ERK1/2 occurs in and is mediated by gastrointestinal vagal afferents.	Capsaicin	76-85	mitogen activated protein kinase 3	Rattus norvegicus	19-25
22508518-6	2012	CCK-evoked phospho-ERK1/2 in the NTS was attenuated in rats pretreated with capsaicin and was abolished by systemic injection of a CCK1 receptor antagonist, indicating that phosphorylation of ERK1/2 occurs in and is mediated by gastrointestinal vagal afferents.	Capsaicin	76-85	mitogen activated protein kinase 3	Rattus norvegicus	192-198
22792028-0	2012	Capsaicin Blocks the Hyperpolarization-Activated Inward Currents via TRPV1 in the Rat Dorsal Root Ganglion Neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	69-74
22792028-6	2012	The capsaicin-induced inhibition of I(h) was prevented by preexposing the TRPV1 antagonist, capsazepine (CPZ).	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	74-79
22792028-8	2012	In summary, the inhibitory effects of capsaicin on I(h) are mediated by activation of TRPV1 and Ca(2+)-triggered cellular responses.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	86-91
21219440-8	2012	Because some of the lipoxygenase products are potent vanilloid agonists, the stimulation of TRPV1 receptors besides leukotriene receptors seems to participate in the potentiation of contraction response in sensitized guinea-pig tracheas.	Capsaicin	53-62	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	92-97
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	26-35	latexin	Homo sapiens	48-51
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	26-35	latexin	Homo sapiens	118-121
21859781-3	2012	Effects of capsaicin involved endoplasmic reticulum (ER) stress, caspase-3 activation and mitochondrial depolarization.	Capsaicin	11-20	caspase 3	Homo sapiens	65-74
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	26-35	transient receptor potential cation channel subfamily V member 4	Homo sapiens	128-133
21859781-5	2012	Capsaicin treatment triggered ER stress by promoting the production of reactive oxygen species (ROS), increasing levels of inositol-requiring 1 enzyme (IRE1), growth arrest and DNA-damage-inducible 153 (GADD153) and glucose-regulated protein 78 (GRP78).	Capsaicin	0-9	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	123-150
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	26-35	latexin	Homo sapiens	118-121
21859781-5	2012	Capsaicin treatment triggered ER stress by promoting the production of reactive oxygen species (ROS), increasing levels of inositol-requiring 1 enzyme (IRE1), growth arrest and DNA-damage-inducible 153 (GADD153) and glucose-regulated protein 78 (GRP78).	Capsaicin	0-9	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	152-156
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	26-35	latexin	Homo sapiens	118-121
21859781-5	2012	Capsaicin treatment triggered ER stress by promoting the production of reactive oxygen species (ROS), increasing levels of inositol-requiring 1 enzyme (IRE1), growth arrest and DNA-damage-inducible 153 (GADD153) and glucose-regulated protein 78 (GRP78).	Capsaicin	0-9	DNA damage inducible transcript 3	Homo sapiens	159-201
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	37-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	12-17
21859781-5	2012	Capsaicin treatment triggered ER stress by promoting the production of reactive oxygen species (ROS), increasing levels of inositol-requiring 1 enzyme (IRE1), growth arrest and DNA-damage-inducible 153 (GADD153) and glucose-regulated protein 78 (GRP78).	Capsaicin	0-9	DNA damage inducible transcript 3	Homo sapiens	203-210
21859781-5	2012	Capsaicin treatment triggered ER stress by promoting the production of reactive oxygen species (ROS), increasing levels of inositol-requiring 1 enzyme (IRE1), growth arrest and DNA-damage-inducible 153 (GADD153) and glucose-regulated protein 78 (GRP78).	Capsaicin	0-9	heat shock protein family A (Hsp70) member 5	Homo sapiens	216-244
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	37-40	latexin	Homo sapiens	48-51
21859781-5	2012	Capsaicin treatment triggered ER stress by promoting the production of reactive oxygen species (ROS), increasing levels of inositol-requiring 1 enzyme (IRE1), growth arrest and DNA-damage-inducible 153 (GADD153) and glucose-regulated protein 78 (GRP78).	Capsaicin	0-9	heat shock protein family A (Hsp70) member 5	Homo sapiens	246-251
21859781-7	2012	Furthermore, capsaicin induced increases in the ratio of Bax/Bcl-2 and abundance of apoptosis-related protein levels.	Capsaicin	13-22	BCL2 associated X, apoptosis regulator	Homo sapiens	57-60
21859781-7	2012	Furthermore, capsaicin induced increases in the ratio of Bax/Bcl-2 and abundance of apoptosis-related protein levels.	Capsaicin	13-22	BCL2 apoptosis regulator	Homo sapiens	61-66
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	37-40	latexin	Homo sapiens	118-121
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	37-40	transient receptor potential cation channel subfamily V member 4	Homo sapiens	128-133
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	37-40	latexin	Homo sapiens	118-121
22327830-9	2012	Whereas the TRPV1 agonist capsaicin (CAP) (5-20 muM) -induced Ca(2+) transients were blocked by capsazepine (CPZ) (10 muM), the TRPV4 activator 4alpha-PDD (10 muM) -induced Ca(2+) increases were reduced by ruthenium-red (RuR) (20 muM).	Capsaicin	37-40	latexin	Homo sapiens	118-121
21764279-0	2012	Capsaicin represses transcriptional activity of beta-catenin in human colorectal cancer cells.	Capsaicin	0-9	catenin beta 1	Homo sapiens	48-60
22493457-1	2012	TRPV1 receptor agonists such as the vanilloid capsaicin and the potent analog resiniferatoxin are well known potent analgesics.	Capsaicin	46-55	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
21764279-3	2012	In the present study, we investigated whether capsaicin alters beta-catenin-dependent signaling in human colorectal cancer cells in vitro.	Capsaicin	46-55	catenin beta 1	Homo sapiens	63-75
21764279-5	2012	Transient transfection with a beta-catenin/T-cell factor (TCF)-responsive reporter indicated that capsaicin suppressed the transcriptional activity of beta-catenin/TCF.	Capsaicin	98-107	hepatocyte nuclear factor 4 alpha	Homo sapiens	30-56
21764279-5	2012	Transient transfection with a beta-catenin/T-cell factor (TCF)-responsive reporter indicated that capsaicin suppressed the transcriptional activity of beta-catenin/TCF.	Capsaicin	98-107	hepatocyte nuclear factor 4 alpha	Homo sapiens	58-61
21764279-5	2012	Transient transfection with a beta-catenin/T-cell factor (TCF)-responsive reporter indicated that capsaicin suppressed the transcriptional activity of beta-catenin/TCF.	Capsaicin	98-107	catenin beta 1	Homo sapiens	30-42
21764279-5	2012	Transient transfection with a beta-catenin/T-cell factor (TCF)-responsive reporter indicated that capsaicin suppressed the transcriptional activity of beta-catenin/TCF.	Capsaicin	98-107	hepatocyte nuclear factor 4 alpha	Homo sapiens	164-167
21764279-6	2012	Capsaicin treatment resulted in a decrease of intracellular beta-catenin levels and a reduction of transcripts from the beta-catenin gene (CTNNB1).	Capsaicin	0-9	catenin beta 1	Homo sapiens	60-72
21764279-6	2012	Capsaicin treatment resulted in a decrease of intracellular beta-catenin levels and a reduction of transcripts from the beta-catenin gene (CTNNB1).	Capsaicin	0-9	catenin beta 1	Homo sapiens	120-132
21764279-6	2012	Capsaicin treatment resulted in a decrease of intracellular beta-catenin levels and a reduction of transcripts from the beta-catenin gene (CTNNB1).	Capsaicin	0-9	catenin beta 1	Homo sapiens	139-145
21764279-8	2012	In addition, capsaicin destabilized beta-catenin through enhancement of proteosomal-dependent degradation.	Capsaicin	13-22	catenin beta 1	Homo sapiens	36-48
21764279-9	2012	Western blot and immunoprecipitation studies indicated that capsaicin treatment suppressed TCF-4 expression and disrupted the interaction of TCF-4 and beta-catenin.	Capsaicin	60-69	transcription factor 4	Homo sapiens	91-96
21764279-9	2012	Western blot and immunoprecipitation studies indicated that capsaicin treatment suppressed TCF-4 expression and disrupted the interaction of TCF-4 and beta-catenin.	Capsaicin	60-69	transcription factor 4	Homo sapiens	141-146
21764279-9	2012	Western blot and immunoprecipitation studies indicated that capsaicin treatment suppressed TCF-4 expression and disrupted the interaction of TCF-4 and beta-catenin.	Capsaicin	60-69	catenin beta 1	Homo sapiens	151-163
21764279-10	2012	This study identifies a role for the beta-catenin/TCF-dependent pathway that potentially contributes to the anticancer activity of capsaicin in human colorectal cancer cells.	Capsaicin	131-140	catenin beta 1	Homo sapiens	37-49
21764279-10	2012	This study identifies a role for the beta-catenin/TCF-dependent pathway that potentially contributes to the anticancer activity of capsaicin in human colorectal cancer cells.	Capsaicin	131-140	hepatocyte nuclear factor 4 alpha	Homo sapiens	50-53
25722695-10	2012	Capsaicin decreased the number of doublecortin-expressing cells in the dentate gyrus, whereas vagotomy did not alter the expression of doublecortin in the hippocampus.	Capsaicin	0-9	doublecortin	Rattus norvegicus	34-46
21859771-5	2012	The combination (both capsaicin and CCl4) group has preserved the liver histology, liver enzymes and bilirubin close to normal, exhibited significant induction in the activities of CAT, SOD and GST, increased the liver content of GSH and active caspase-3 and conversely showed significant decrease in liver MDA content compared to CCl4 challenged rats.	Capsaicin	22-31	catalase	Rattus norvegicus	181-184
21859771-5	2012	The combination (both capsaicin and CCl4) group has preserved the liver histology, liver enzymes and bilirubin close to normal, exhibited significant induction in the activities of CAT, SOD and GST, increased the liver content of GSH and active caspase-3 and conversely showed significant decrease in liver MDA content compared to CCl4 challenged rats.	Capsaicin	22-31	hematopoietic prostaglandin D synthase	Rattus norvegicus	194-197
21859771-5	2012	The combination (both capsaicin and CCl4) group has preserved the liver histology, liver enzymes and bilirubin close to normal, exhibited significant induction in the activities of CAT, SOD and GST, increased the liver content of GSH and active caspase-3 and conversely showed significant decrease in liver MDA content compared to CCl4 challenged rats.	Capsaicin	22-31	caspase 3	Rattus norvegicus	245-254
21859771-5	2012	The combination (both capsaicin and CCl4) group has preserved the liver histology, liver enzymes and bilirubin close to normal, exhibited significant induction in the activities of CAT, SOD and GST, increased the liver content of GSH and active caspase-3 and conversely showed significant decrease in liver MDA content compared to CCl4 challenged rats.	Capsaicin	22-31	C-C motif chemokine ligand 4	Rattus norvegicus	331-335
21859771-6	2012	Capsaicin confers an appealing hepatoprotective effect which might be explained partially via diminishing the generation of MDA, induction of antioxidant systems and inhibition of active caspase-3.	Capsaicin	0-9	caspase 3	Rattus norvegicus	187-196
22414871-11	2012	SPARC-null mice developed (1) region-specific, age-dependent hypersensitivity to cold, icilin, and capsaicin (hind paw only), (2) axial discomfort, (3) motor impairment, and (4) reduced physical function.	Capsaicin	99-108	secreted acidic cysteine rich glycoprotein	Mus musculus	0-5
21859771-1	2012	The aim of the study was to evaluate the potential hepatoprotective utility of capsaicin against carbon tetrachloride (CCl4)-induced liver injury and to explore the possible mechanisms whereby this agent mediated its beneficial effects.	Capsaicin	79-88	C-C motif chemokine ligand 4	Rattus norvegicus	119-123
22516465-3	2012	On the average, capsaicin increased cAMP, cGMP concentration and SP release in bell-shaped concentration-dependent manner, with the maximal responses at concentrations around 1 muM, suggesting acute desensitization of TRPV1 receptor activation.	Capsaicin	16-25	latexin	Homo sapiens	177-180
22516465-3	2012	On the average, capsaicin increased cAMP, cGMP concentration and SP release in bell-shaped concentration-dependent manner, with the maximal responses at concentrations around 1 muM, suggesting acute desensitization of TRPV1 receptor activation.	Capsaicin	16-25	transient receptor potential cation channel subfamily V member 1	Homo sapiens	218-223
22421400-10	2012	Capsaicin (0.1-10 muM) was ineffective in causing ATP release, and also failed to contract porcine mucosal or detrusor strips.	Capsaicin	0-9	latexin	Homo sapiens	18-21
22451679-4	2012	Additionally, TGF-beta1 enhances the capsaicin-induced Ca(2+) influx in cultured primary neurons from dorsal root ganglia (DRG).	Capsaicin	37-46	transforming growth factor, beta 1	Mus musculus	14-23
22459208-3	2012	It has been reported that the anti-diabetic drug metformin and some natural compounds, such as quercetin, genistein, capsaicin and green tea polyphenol epigallocatechin gallate (EGCG), can activate AMPK and inhibit cancer cell growth.	Capsaicin	117-126	protein kinase AMP-activated catalytic subunit alpha 2	Homo sapiens	198-202
22378771-8	2012	CGRP content was significantly decreased in capsaicin-treated IBAT demonstrating successful sensory nerve destruction.	Capsaicin	44-53	calcitonin related polypeptide alpha	Homo sapiens	0-4
22378771-8	2012	CGRP content was significantly decreased in capsaicin-treated IBAT demonstrating successful sensory nerve destruction.	Capsaicin	44-53	solute carrier family 10 member 2	Homo sapiens	62-66
22378771-9	2012	T(IBAT) and T(c) were significantly decreased in capsaicin-treated hamsters compared with the saline controls at 2 h of cold exposure.	Capsaicin	49-58	solute carrier family 10 member 2	Homo sapiens	0-7
22688302-1	2012	Transient receptor potential vanilloid subfamily member 1 (TRPV1) is activated by capsaicin, acid, and heat and mediates pain through peripheral nerves.	Capsaicin	82-91	transient receptor potential cation channel subfamily V member 1	Homo sapiens	59-64
20925121-0	2012	Capsaicin induces apoptosis in SCC-4 human tongue cancer cells through mitochondria-dependent and -independent pathways.	Capsaicin	0-9	MAU2 sister chromatid cohesion factor	Homo sapiens	31-36
20925121-5	2012	Capsaicin decreased the percentage of viable cells in a dose-dependent manner in human tongue cancer SCC-4 cells.	Capsaicin	0-9	MAU2 sister chromatid cohesion factor	Homo sapiens	101-106
20925121-6	2012	In addition, capsaicin produced DNA fragmentation, decreased the DNA contents (sub-G1 phase), and induced G0/G1 phase arrest in SCC-4 cells.	Capsaicin	13-22	MAU2 sister chromatid cohesion factor	Homo sapiens	128-133
20925121-8	2012	Treatment with capsaicin induced a dramatic increase in caspase-3 and -9 activities, as assessed by flow cytometric methods.	Capsaicin	15-24	caspase 3	Homo sapiens	56-72
20925121-9	2012	A possible mechanism of capsaicin-induced apoptosis is involved in the activation of caspase-3 (one of the apoptosis-executing enzyme).	Capsaicin	24-33	caspase 3	Homo sapiens	85-94
20925121-10	2012	Confocal laser microscope examination also showed that capsaicin induced the releases of AIF, ATF-4, and GADD153 from mitochondria of SCC-4 cells.	Capsaicin	55-64	activating transcription factor 4	Homo sapiens	94-99
20925121-10	2012	Confocal laser microscope examination also showed that capsaicin induced the releases of AIF, ATF-4, and GADD153 from mitochondria of SCC-4 cells.	Capsaicin	55-64	DNA damage inducible transcript 3	Homo sapiens	105-112
20925121-10	2012	Confocal laser microscope examination also showed that capsaicin induced the releases of AIF, ATF-4, and GADD153 from mitochondria of SCC-4 cells.	Capsaicin	55-64	MAU2 sister chromatid cohesion factor	Homo sapiens	134-139
22289052-10	2012	Capsaicin, a TRPV1 agonist, produced depolarization and repetitive action potential firing in current clamp recordings, and large inward currents in voltage clamp recordings from acutely dissociated TG neurons, demonstrating that TRPV1 channels are functional in trigeminal neurons.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	13-18
22420714-0	2012	The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs.	Capsaicin	62-71	polycystin 1 like 3, transient receptor potential channel interacting	Homo sapiens	16-22
22420714-0	2012	The response of PKD1L3/PKD2L1 to acid stimuli is inhibited by capsaicin and its pungent analogs.	Capsaicin	62-71	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	23-29
22420714-6	2012	We found that capsaicin and its analogs, which are TRPV1 agonists, inhibited the response to acid stimuli and that the capsaicin inhibition was reversible with an IC(50) of 32.5 mum.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
22420714-6	2012	We found that capsaicin and its analogs, which are TRPV1 agonists, inhibited the response to acid stimuli and that the capsaicin inhibition was reversible with an IC(50) of 32.5 mum.	Capsaicin	119-128	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
22420714-7	2012	Capsaicin and its analogs are thus useful tools for physiological analysis of PKD1L3/PKD2L1 function.	Capsaicin	0-9	polycystin 1 like 3, transient receptor potential channel interacting	Homo sapiens	78-84
22420714-7	2012	Capsaicin and its analogs are thus useful tools for physiological analysis of PKD1L3/PKD2L1 function.	Capsaicin	0-9	polycystin 2 like 1, transient receptor potential cation channel	Homo sapiens	85-91
22289052-10	2012	Capsaicin, a TRPV1 agonist, produced depolarization and repetitive action potential firing in current clamp recordings, and large inward currents in voltage clamp recordings from acutely dissociated TG neurons, demonstrating that TRPV1 channels are functional in trigeminal neurons.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	230-235
22566028-5	2012	TRPV1 agonist capsaicin mediated a concentration-dependent increase in TRPV1 inward currents and MUC5AC secretion.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
23493622-9	2012	Intra-CA1 infusion of capsaicin (0.003, 0.03 and 0.3 microg/rat) increased the anxiety-related behaviors and AM 251 (0.001, 0.01 and 0.1 microg/rat) did not significantly change the animals behavior.	Capsaicin	22-31	carbonic anhydrase 1	Rattus norvegicus	6-9
22566028-5	2012	TRPV1 agonist capsaicin mediated a concentration-dependent increase in TRPV1 inward currents and MUC5AC secretion.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
22566028-5	2012	TRPV1 agonist capsaicin mediated a concentration-dependent increase in TRPV1 inward currents and MUC5AC secretion.	Capsaicin	14-23	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	97-103
22566028-6	2012	Furthermore, capsaicin enhanced acid-induced TRPV1 inward currents and MUC5AC secretion.	Capsaicin	13-22	transient receptor potential cation channel subfamily V member 1	Homo sapiens	45-50
22566028-6	2012	Furthermore, capsaicin enhanced acid-induced TRPV1 inward currents and MUC5AC secretion.	Capsaicin	13-22	mucin 5AC, oligomeric mucus/gel-forming	Homo sapiens	71-77
21956871-7	2012	Treating submandibular gland tissues with capsaicin, an agonist of TRPV1, substantially increased the phosphorylation of the 20-kDa regulatory light-chain subunit of myosin (MLC(20) ), a crucial molecule for contraction of smooth muscle cells, in MECs.	Capsaicin	42-51	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
22391958-5	2012	RT-PCR and western blot analysis revealed that capsaicin upregulated expression of zonula occludin-1 (ZO-1), claudin (Cldn)-3, and -11, but not Cldn-1, -2, -4, -5, and -7 in cultured SMG cells.	Capsaicin	47-56	claudin-3	Oryctolagus cuniculus	109-125
22391958-6	2012	Capsaicin also increased the entering of 4 kDa FITC-dextran into the acinar lumen, induced redistribution of cytoskeleton F-actin under confocal microscope, and these effects were abolished by preincubation of capsazepine, a TRPV1 antagonist, indicating that activation of TRPV1 increases expression and permeability of TJ in SMG.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	225-230
22391958-6	2012	Capsaicin also increased the entering of 4 kDa FITC-dextran into the acinar lumen, induced redistribution of cytoskeleton F-actin under confocal microscope, and these effects were abolished by preincubation of capsazepine, a TRPV1 antagonist, indicating that activation of TRPV1 increases expression and permeability of TJ in SMG.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	273-278
21956871-7	2012	Treating submandibular gland tissues with capsaicin, an agonist of TRPV1, substantially increased the phosphorylation of the 20-kDa regulatory light-chain subunit of myosin (MLC(20) ), a crucial molecule for contraction of smooth muscle cells, in MECs.	Capsaicin	42-51	myosin light chain 12B	Homo sapiens	174-181
21956871-8	2012	Pretreatment with capsazepine, a specific TRPV1 inhibitor, blocked capsaicin-induced MLC(20) phosphorylation.	Capsaicin	67-76	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
21956871-8	2012	Pretreatment with capsazepine, a specific TRPV1 inhibitor, blocked capsaicin-induced MLC(20) phosphorylation.	Capsaicin	67-76	myosin light chain 12B	Homo sapiens	85-91
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	25-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	85-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-54
22648626-0	2012	Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein beta activation.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	18-24
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	85-94	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	126-132
22648626-0	2012	Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein beta activation.	Capsaicin	0-9	nuclear receptor subfamily 1 group I member 2	Homo sapiens	40-59
22381959-6	2012	mRNA of nerve growth factor (NGF) in the muscle, which plays a pivotal role in maintaining mechanical hyperalgesia, was upregulated in the capsaicin treated animals similar to the vehicle treated animals.	Capsaicin	139-148	nerve growth factor	Rattus norvegicus	8-27
22648626-0	2012	Capsaicin induces CYP3A4 expression via pregnane X receptor and CCAAT/enhancer-binding protein beta activation.	Capsaicin	0-9	CCAAT enhancer binding protein beta	Homo sapiens	64-99
22648626-3	2012	However, the influence of capsaicin on CYP3A4, its involvement in drug metabolism, and the underlying mechanisms remain unclear.	Capsaicin	26-35	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	39-45
22648626-4	2012	METHODS AND RESULTS: Here, we examined the effect of capsaicin on CYP3A4 expression and the metabolism of CYP3A1 substrate, nifedipine in male Sprague-Dawley rats.	Capsaicin	53-62	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	66-72
22648626-5	2012	Capsaicin induced the enzymatic activity and expression of CYP3A4 in HepG2 cells.	Capsaicin	0-9	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	59-65
22648626-6	2012	Treatment with a human pregnane X receptor (hPXR) inhibitor reduced the inductive effects of capsaicin on CYP3A4 expression.	Capsaicin	93-102	nuclear receptor subfamily 1 group I member 2	Homo sapiens	23-42
22648626-6	2012	Treatment with a human pregnane X receptor (hPXR) inhibitor reduced the inductive effects of capsaicin on CYP3A4 expression.	Capsaicin	93-102	nuclear receptor subfamily 1 group I member 2	Homo sapiens	44-48
22648626-6	2012	Treatment with a human pregnane X receptor (hPXR) inhibitor reduced the inductive effects of capsaicin on CYP3A4 expression.	Capsaicin	93-102	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	106-112
22648626-7	2012	Capsaicin also induced the activation of CCAAT/enhancer-binding protein beta (C/EBPbeta).	Capsaicin	0-9	CCAAT enhancer binding protein beta	Homo sapiens	41-76
22648626-7	2012	Capsaicin also induced the activation of CCAAT/enhancer-binding protein beta (C/EBPbeta).	Capsaicin	0-9	CCAAT enhancer binding protein beta	Homo sapiens	78-87
22648626-8	2012	Moreover, capsaicin increased the activation of the transient receptor potential vanilloid type-1 receptor downstream signaling components Ca2+/calmodulin-dependent protein kinase and Akt.	Capsaicin	10-19	AKT serine/threonine kinase 1	Homo sapiens	184-187
22648626-9	2012	Capsaicin elevated the level of CYP3A1 in rat liver and significantly increased the biotransformation of nifedipine to dehydronifedipine.	Capsaicin	0-9	cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1	Rattus norvegicus	32-38
22648626-10	2012	CONCLUSION: From these data, we conclude that capsaicin induces CYP3A4 expression in vitro and in vivo.	Capsaicin	46-55	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	64-70
22648626-12	2012	Our results suggest that capsaicin might induce CYP3A4 expression; thus, exposure to capsaicin may increase the metabolism of CYP3A4 substrate and potentially cause food-drug interactions.	Capsaicin	25-34	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	48-54
22381959-6	2012	mRNA of nerve growth factor (NGF) in the muscle, which plays a pivotal role in maintaining mechanical hyperalgesia, was upregulated in the capsaicin treated animals similar to the vehicle treated animals.	Capsaicin	139-148	nerve growth factor	Rattus norvegicus	29-32
21545651-1	2012	AIMS: This study was designed to determine if steroids, capsaicin and mitomycin improved skin flap survival in rats, and it has confirmed that thermography is an effective method to measured skin flap vitality.	Capsaicin	56-65	arachidonate 5-lipoxygenase activating protein	Rattus norvegicus	94-98
22425716-5	2012	Two, we determined if TxA2R co-localizes with mRNA for the nociceptive marker, TRPV1, which is the receptor for the noxious substance capsaicin.	Capsaicin	134-143	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	79-84
22328719-1	2012	Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-45
22328719-1	2012	Transient receptor potential vanilloid type 1 (TRPV1) is a nonselective cation channel activated by capsaicin, low pH, and noxious heat and plays a key role in nociception.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
22328719-3	2012	One characteristic of TRPV1 is that channel activity induced by either capsaicin or other activators can be sensitized or modulated by factors involving different cell signaling mechanisms.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	22-27
22328719-5	2012	We found that, in rat dorsal root ganglion neurons, although DIDS did not induce the activation of TRPV1 per se but drastically increased the TRPV1 currents induced by either capsaicin or low pH.	Capsaicin	175-184	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	142-147
22328719-9	2012	DIDS also potentiated the currents of TRPV1 channels expressed in human embryonic kidney 293 cells, with an effect of left-shifting the concentration-response curve of the capsaicin-induced TRPV1 currents.	Capsaicin	172-181	transient receptor potential cation channel subfamily V member 1	Homo sapiens	38-43
22328719-9	2012	DIDS also potentiated the currents of TRPV1 channels expressed in human embryonic kidney 293 cells, with an effect of left-shifting the concentration-response curve of the capsaicin-induced TRPV1 currents.	Capsaicin	172-181	transient receptor potential cation channel subfamily V member 1	Homo sapiens	190-195
22314222-8	2012	Pretreatment with capsaicin (a depletor of calcitonin gene-related peptide (CGRP)-containing nerves, 5muM) significantly inhibited the vasodilation without affecting the initial vasoconstriction.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	43-74
22532967-1	2012	Capsaicin, an activator of the transient potential vanilloid receptor type 1 (TRPV1), is a commonly used pharmacological tool for desensitising sensory nerves.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	78-83
22532967-2	2012	Capsaicin can induce vasorelaxation of isolated blood vessels by activating perivascular TRPV1 receptors, causing the release of vasoactive neuropeptides.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	89-94
22532967-12	2012	In summary,we have identified a potential mechanism underlying TRPV1-independent capsaicin-induced vasorelaxation.	Capsaicin	81-90	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	63-68
22389490-1	2012	TRPV1 is a member of the transient receptor potential ion channel family and is gated by capsaicin, the pungent component of chili pepper.	Capsaicin	89-98	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
22314222-8	2012	Pretreatment with capsaicin (a depletor of calcitonin gene-related peptide (CGRP)-containing nerves, 5muM) significantly inhibited the vasodilation without affecting the initial vasoconstriction.	Capsaicin	18-27	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
22314222-10	2012	These results suggest that histamine-induced vasoconstriction and long-lasting vasodilation are mediated by activation of TRPV1 on capsaicin-sensitive and capsaicin-insensitive nerves.	Capsaicin	131-140	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	122-127
22314222-10	2012	These results suggest that histamine-induced vasoconstriction and long-lasting vasodilation are mediated by activation of TRPV1 on capsaicin-sensitive and capsaicin-insensitive nerves.	Capsaicin	155-164	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	122-127
22314297-1	2012	BACKGROUND: The recent discovery that camphor activates and strongly desensitizes the capsaicin-sensitive and noxious heat-sensitive channel transient receptor potential vanilloid subfamily member 1 (TRPV1) has provided new insights and opened up new research paths toward understanding why this naturally occurring monoterpene is widely used in human medicine for its local counter-irritant, antipruritic, and anesthetic properties.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	200-205
21955128-8	2012	We demonstrated that CAP induced expression of NOS isotypes including eNOS, iNOS and nNOS in prepubertal rat ovaries.	Capsaicin	21-24	nitric oxide synthase 2	Rattus norvegicus	76-80
21955128-8	2012	We demonstrated that CAP induced expression of NOS isotypes including eNOS, iNOS and nNOS in prepubertal rat ovaries.	Capsaicin	21-24	nitric oxide synthase 1	Rattus norvegicus	85-89
22466126-4	2012	METHODS: Activation of the TRPV1 receptor with capsaicin was studied with patch clamp methods in acutely isolated small-diameter rat sensory neurons in primary culture.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
22125310-0	2012	House dust mite potentiates capsaicin-evoked Ca2+ transients in mouse pulmonary sensory neurons via activation of protease-activated receptor-2.	Capsaicin	28-37	coagulation factor II (thrombin) receptor-like 1	Mus musculus	114-143
22125310-6	2012	In addition, the potentiating effect of HDM on capsaicin-evoked Ca(2+) transient was absent in the pulmonary sensory neurons isolated from protease-activated receptor-2 (PAR(2)) knockout mice.	Capsaicin	47-56	coagulation factor II (thrombin) receptor-like 1	Mus musculus	139-168
22125310-6	2012	In addition, the potentiating effect of HDM on capsaicin-evoked Ca(2+) transient was absent in the pulmonary sensory neurons isolated from protease-activated receptor-2 (PAR(2)) knockout mice.	Capsaicin	47-56	coagulation factor II (thrombin) receptor-like 1	Mus musculus	170-176
22125310-8	2012	In summary, our results demonstrate that HDM, mainly through its serine protease activity, potentiates capsaicin-evoked Ca(2+) transient in mouse pulmonary sensory neurons via the activation of PAR(2) and the phosholipase C-protein kinase C intracellular transduction cascade.	Capsaicin	103-112	coagulation factor II (thrombin) receptor-like 1	Mus musculus	194-200
22653901-17	2012	This is supported by the fact that the addition of specific COX-1 or COX-2 inhibitors to animals with capsaicin denervation led to exacerbation of gastric lesions, and further fall in the antioxidizing status of gastric mucosa exposed to stress.	Capsaicin	102-111	cytochrome c oxidase I, mitochondrial	Rattus norvegicus	60-65
22653901-17	2012	This is supported by the fact that the addition of specific COX-1 or COX-2 inhibitors to animals with capsaicin denervation led to exacerbation of gastric lesions, and further fall in the antioxidizing status of gastric mucosa exposed to stress.	Capsaicin	102-111	cytochrome c oxidase II, mitochondrial	Rattus norvegicus	69-74
22466126-6	2012	RESULTS: Neurons isolated from lumbar DRGs 3 days after local inflammation showed enhanced TRPV1 function: tachyphylaxis (the decline in response to repeated applications of capsaicin) was significantly reduced.	Capsaicin	174-183	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
22466126-9	2012	Consistent with the in vitro results, in vivo behavioral responses to paw injection of capsaicin were enhanced and prolonged by pre-injecting the paw with GRO/KC 4 h before the capsaicin injection.	Capsaicin	87-96	C-X-C motif chemokine ligand 1	Rattus norvegicus	155-158
22466126-9	2012	Consistent with the in vitro results, in vivo behavioral responses to paw injection of capsaicin were enhanced and prolonged by pre-injecting the paw with GRO/KC 4 h before the capsaicin injection.	Capsaicin	177-186	C-X-C motif chemokine ligand 1	Rattus norvegicus	155-158
22366261-5	2012	Grooming behavior after capsaicin injection into the whisker pad region was significantly increased after IAN transection and the increase in the behavior was reversed by systemic administration of a TRPV1 antagonist.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	200-205
22353011-0	2012	Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	19-23
22306243-4	2012	Pulmonary hypertension was induced by hypoxia in rats, and capsaicin (50 mg/kg, s.c.) was used to deplete endogenous CGRP.	Capsaicin	59-68	calcitonin-related polypeptide alpha	Rattus norvegicus	117-121
22306243-7	2012	Sensory CGRP depletion by capsaicin exacerbated hypoxia-induced pulmonary hypertension in rats, as shown by an increase in right ventricle systolic pressure, mean pulmonary artery pressure and vascular hypertrophy, accompanied with decreased p27 expression and increased expression of phosphorylated ERK1/2, c-fos and c-myc.	Capsaicin	26-35	calcitonin-related polypeptide alpha	Rattus norvegicus	8-12
22306243-7	2012	Sensory CGRP depletion by capsaicin exacerbated hypoxia-induced pulmonary hypertension in rats, as shown by an increase in right ventricle systolic pressure, mean pulmonary artery pressure and vascular hypertrophy, accompanied with decreased p27 expression and increased expression of phosphorylated ERK1/2, c-fos and c-myc.	Capsaicin	26-35	cyclin-dependent kinase inhibitor 1B	Rattus norvegicus	242-245
22306243-7	2012	Sensory CGRP depletion by capsaicin exacerbated hypoxia-induced pulmonary hypertension in rats, as shown by an increase in right ventricle systolic pressure, mean pulmonary artery pressure and vascular hypertrophy, accompanied with decreased p27 expression and increased expression of phosphorylated ERK1/2, c-fos and c-myc.	Capsaicin	26-35	mitogen activated protein kinase 3	Rattus norvegicus	300-306
22306243-7	2012	Sensory CGRP depletion by capsaicin exacerbated hypoxia-induced pulmonary hypertension in rats, as shown by an increase in right ventricle systolic pressure, mean pulmonary artery pressure and vascular hypertrophy, accompanied with decreased p27 expression and increased expression of phosphorylated ERK1/2, c-fos and c-myc.	Capsaicin	26-35	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	308-313
22306243-7	2012	Sensory CGRP depletion by capsaicin exacerbated hypoxia-induced pulmonary hypertension in rats, as shown by an increase in right ventricle systolic pressure, mean pulmonary artery pressure and vascular hypertrophy, accompanied with decreased p27 expression and increased expression of phosphorylated ERK1/2, c-fos and c-myc.	Capsaicin	26-35	MYC proto-oncogene, bHLH transcription factor	Rattus norvegicus	318-323
22226932-3	2012	Capsaicin treatment of MCF-7 cells induced S-phase arrest and autophagy through the AMPKalpha-mTOR signaling pathway and the accumulation of p53 in the nucleus and cytosol, including a change in mitochondrial membrane potential.	Capsaicin	0-9	tumor protein p53	Homo sapiens	141-144
22226932-4	2012	Capsaicin treatment also activated delta-H2AX, ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and poly(ADP-ribose) polymerase (PARP)-1.	Capsaicin	0-9	ATM serine/threonine kinase	Homo sapiens	47-76
22226932-4	2012	Capsaicin treatment also activated delta-H2AX, ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and poly(ADP-ribose) polymerase (PARP)-1.	Capsaicin	0-9	ATM serine/threonine kinase	Homo sapiens	78-81
22226932-4	2012	Capsaicin treatment also activated delta-H2AX, ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and poly(ADP-ribose) polymerase (PARP)-1.	Capsaicin	0-9	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	84-130
22226932-4	2012	Capsaicin treatment also activated delta-H2AX, ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and poly(ADP-ribose) polymerase (PARP)-1.	Capsaicin	0-9	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	132-140
22226932-4	2012	Capsaicin treatment also activated delta-H2AX, ataxia telangiectasia mutated (ATM), DNA-dependent protein kinase catalytic subunit (DNA-PKcs), and poly(ADP-ribose) polymerase (PARP)-1.	Capsaicin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	147-183
22226932-5	2012	Genetic or pharmacological disruption of autophagy attenuated capsaicin-induced phospho-ATM and phospho-DNA-PKcs and enhanced apoptotic cell death.	Capsaicin	62-71	ATM serine/threonine kinase	Homo sapiens	88-91
22226932-5	2012	Genetic or pharmacological disruption of autophagy attenuated capsaicin-induced phospho-ATM and phospho-DNA-PKcs and enhanced apoptotic cell death.	Capsaicin	62-71	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	104-112
22226932-6	2012	ATM inhibitors, including Ku55933 and caffeine, and the genetic or pharmacological inhibition of p53 prevented capsaicin-induced DNA-PKcs phosphorylation and stimulated PARP-1 cleavage, but had no effect on microtubule-associated protein light chain 3 (LC3)-II levels.	Capsaicin	111-120	ATM serine/threonine kinase	Homo sapiens	0-3
22226932-6	2012	ATM inhibitors, including Ku55933 and caffeine, and the genetic or pharmacological inhibition of p53 prevented capsaicin-induced DNA-PKcs phosphorylation and stimulated PARP-1 cleavage, but had no effect on microtubule-associated protein light chain 3 (LC3)-II levels.	Capsaicin	111-120	tumor protein p53	Homo sapiens	97-100
22226932-6	2012	ATM inhibitors, including Ku55933 and caffeine, and the genetic or pharmacological inhibition of p53 prevented capsaicin-induced DNA-PKcs phosphorylation and stimulated PARP-1 cleavage, but had no effect on microtubule-associated protein light chain 3 (LC3)-II levels.	Capsaicin	111-120	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	129-137
22226932-6	2012	ATM inhibitors, including Ku55933 and caffeine, and the genetic or pharmacological inhibition of p53 prevented capsaicin-induced DNA-PKcs phosphorylation and stimulated PARP-1 cleavage, but had no effect on microtubule-associated protein light chain 3 (LC3)-II levels.	Capsaicin	111-120	poly(ADP-ribose) polymerase 1	Homo sapiens	169-175
22226932-7	2012	Ly294002, a DNA-PKcs inhibitor, boosted the capsaicin-induced cleavage of PARP-1.	Capsaicin	44-53	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	12-20
22226932-7	2012	Ly294002, a DNA-PKcs inhibitor, boosted the capsaicin-induced cleavage of PARP-1.	Capsaicin	44-53	poly(ADP-ribose) polymerase 1	Homo sapiens	74-80
22226932-8	2012	In M059K cells, but not M059J cells, capsaicin induced ATM and DNA-PKcs phosphorylation, p53 accumulation, and the stimulation of LC3II production, all of which were attenuated by knockdown of the autophagy-related gene atg5.	Capsaicin	37-46	ATM serine/threonine kinase	Homo sapiens	55-58
22226932-8	2012	In M059K cells, but not M059J cells, capsaicin induced ATM and DNA-PKcs phosphorylation, p53 accumulation, and the stimulation of LC3II production, all of which were attenuated by knockdown of the autophagy-related gene atg5.	Capsaicin	37-46	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	63-71
22226932-8	2012	In M059K cells, but not M059J cells, capsaicin induced ATM and DNA-PKcs phosphorylation, p53 accumulation, and the stimulation of LC3II production, all of which were attenuated by knockdown of the autophagy-related gene atg5.	Capsaicin	37-46	tumor protein p53	Homo sapiens	89-92
22226932-8	2012	In M059K cells, but not M059J cells, capsaicin induced ATM and DNA-PKcs phosphorylation, p53 accumulation, and the stimulation of LC3II production, all of which were attenuated by knockdown of the autophagy-related gene atg5.	Capsaicin	37-46	autophagy related 5	Homo sapiens	220-224
22226932-9	2012	Ku55933 attenuated capsaicin-induced phospho-DNA-PKcs, but not LC3II, in M059K cells.	Capsaicin	19-28	protein kinase, DNA-activated, catalytic subunit	Homo sapiens	45-53
22353011-0	2012	Capsaicin-mediated tNOX (ENOX2) up-regulation enhances cell proliferation and migration in vitro and in vivo.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	25-30
22353011-4	2012	Here, we made the unexpected discovery that treatment with low concentrations of capsaicin up-regulates tNOX (tumor-associated NADH oxidase) expression in HCT116 human colon carcinoma cells in association with enhanced cell proliferation and migration, as evidenced by down-regulation of epithelial markers and up-regulation of mesenchymal markers.	Capsaicin	81-90	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	104-108
22353011-4	2012	Here, we made the unexpected discovery that treatment with low concentrations of capsaicin up-regulates tNOX (tumor-associated NADH oxidase) expression in HCT116 human colon carcinoma cells in association with enhanced cell proliferation and migration, as evidenced by down-regulation of epithelial markers and up-regulation of mesenchymal markers.	Capsaicin	81-90	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	110-139
22353011-5	2012	Importantly, tNOX-knockdown in HCT116 cells by RNA interference reversed capsaicin-induced cell proliferation and migration in vitro and decreased tumor growth in vivo.	Capsaicin	73-82	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	13-17
21883148-6	2012	KEY RESULTS: Capsaicin evoked a constrictor response in isolated arteries similar to that mediated by noradrenaline, this was absent in arteries from TRPV1 knockout mice and competitively inhibited by TRPV1 antagonist AMG9810.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	201-206
22184123-5	2012	In this study, we examined the behavior of heteromeric TRPV1/TRPV3 channels activated by heat, capsaicin, and voltage.	Capsaicin	95-104	transient receptor potential cation channel subfamily V member 1	Homo sapiens	55-60
22184123-5	2012	In this study, we examined the behavior of heteromeric TRPV1/TRPV3 channels activated by heat, capsaicin, and voltage.	Capsaicin	95-104	transient receptor potential cation channel subfamily V member 3	Homo sapiens	61-66
22184123-3	2012	In rodents, TRPV3 is expressed predominantly in skin keratinocytes, whereas in humans TRPV1 and TRPV3 are co-expressed in sensory neurons of dorsal root ganglia and trigeminal ganglion and are known to form heteromeric channels with distinct single channel conductances as well as sensitivities to TRPV1 activator capsaicin and inhibitor capsazepine.	Capsaicin	314-323	transient receptor potential cation channel subfamily V member 3	Homo sapiens	12-17
22184123-3	2012	In rodents, TRPV3 is expressed predominantly in skin keratinocytes, whereas in humans TRPV1 and TRPV3 are co-expressed in sensory neurons of dorsal root ganglia and trigeminal ganglion and are known to form heteromeric channels with distinct single channel conductances as well as sensitivities to TRPV1 activator capsaicin and inhibitor capsazepine.	Capsaicin	314-323	transient receptor potential cation channel subfamily V member 1	Homo sapiens	86-91
22184123-3	2012	In rodents, TRPV3 is expressed predominantly in skin keratinocytes, whereas in humans TRPV1 and TRPV3 are co-expressed in sensory neurons of dorsal root ganglia and trigeminal ganglion and are known to form heteromeric channels with distinct single channel conductances as well as sensitivities to TRPV1 activator capsaicin and inhibitor capsazepine.	Capsaicin	314-323	transient receptor potential cation channel subfamily V member 3	Homo sapiens	96-101
22184011-4	2012	Here we report the function of TRPV1 in cultured C2C12 myocytes and the effect of TRPV1 activation by dietary capsaicin on energy metabolism and exercise endurance of skeletal muscles in mice.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	82-87
22184011-5	2012	In vitro, capsaicin increased cytosolic free calcium and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression in C2C12 myotubes through activating TRPV1.	Capsaicin	10-19	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	57-124
22184011-5	2012	In vitro, capsaicin increased cytosolic free calcium and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression in C2C12 myotubes through activating TRPV1.	Capsaicin	10-19	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	126-136
22184011-5	2012	In vitro, capsaicin increased cytosolic free calcium and peroxisome proliferator-activated receptor-gamma coactivator-1alpha (PGC-1alpha) expression in C2C12 myotubes through activating TRPV1.	Capsaicin	10-19	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	186-191
22184011-6	2012	In vivo, PGC-1alpha in skeletal muscle was upregulated by capsaicin-induced TRPV1 activation or genetic overexpression of TRPV1 in mice.	Capsaicin	58-67	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	9-19
22184011-6	2012	In vivo, PGC-1alpha in skeletal muscle was upregulated by capsaicin-induced TRPV1 activation or genetic overexpression of TRPV1 in mice.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	76-81
22184011-8	2012	Importantly, these effects of capsaicin were absent in TRPV1-deficient mice.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	55-60
22184011-9	2012	We conclude that TRPV1 activation by dietary capsaicin improves energy metabolism and exercise endurance by upregulating PGC-1alpha in skeletal muscles.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	17-22
22627148-4	2012	Synaptic transmission between DRG and DH neurons was stimulated by capsaicin, which activates transient receptor potential vanilloid-1 (TRPV1) receptors on small diameter DRG neurons.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	94-134
22184011-9	2012	We conclude that TRPV1 activation by dietary capsaicin improves energy metabolism and exercise endurance by upregulating PGC-1alpha in skeletal muscles.	Capsaicin	45-54	peroxisome proliferative activated receptor, gamma, coactivator 1 alpha	Mus musculus	121-131
22627148-4	2012	Synaptic transmission between DRG and DH neurons was stimulated by capsaicin, which activates transient receptor potential vanilloid-1 (TRPV1) receptors on small diameter DRG neurons.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-141
22242698-8	2012	In stark contrast to the untreated fibroblasts, significant calcium signaling in response to capsaicin and resiniferatoxin in HPBFs treated for 24 and 48 hours with TNF-alpha, LPS, or IL-1alpha was also observed.	Capsaicin	93-102	tumor necrosis factor	Homo sapiens	165-174
22242698-3	2012	The cation channel transient receptor potential vanilloid-1 (TRPV1) is activated by noxious stimuli, including capsaicin, protons, and high temperatures and is thought to have a role in inflammation.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	19-59
22242698-8	2012	In stark contrast to the untreated fibroblasts, significant calcium signaling in response to capsaicin and resiniferatoxin in HPBFs treated for 24 and 48 hours with TNF-alpha, LPS, or IL-1alpha was also observed.	Capsaicin	93-102	interleukin 1 alpha	Homo sapiens	184-193
22242698-3	2012	The cation channel transient receptor potential vanilloid-1 (TRPV1) is activated by noxious stimuli, including capsaicin, protons, and high temperatures and is thought to have a role in inflammation.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	61-66
22379965-7	2012	Topical capsaicin (0.025%) also exerted a moderate suppressive effect on histamine-, substance P-, and PAR-2 agonist-induced itch responses.	Capsaicin	8-17	tachykinin 1	Mus musculus	85-96
22379965-7	2012	Topical capsaicin (0.025%) also exerted a moderate suppressive effect on histamine-, substance P-, and PAR-2 agonist-induced itch responses.	Capsaicin	8-17	pulmonary adenoma resistance 2	Mus musculus	103-108
22379965-9	2012	Therapeutic effects of capsaicin on substance P-induced pruritus did not seem to be mediated by desensitization of the TRPV1 (+) C fibers and/or by altered responsiveness of the mast cells.	Capsaicin	23-32	tachykinin 1	Mus musculus	36-47
20950828-0	2012	TRPV1 agonist capsaicin attenuates lung ischemia-reperfusion injury in rabbits.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	0-5
22080974-4	2012	TRPV1 activation by capsaicin and acidic solution (pH 5.1) induced colonic CGRP/SP release, measured by EIA.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22080974-4	2012	TRPV1 activation by capsaicin and acidic solution (pH 5.1) induced colonic CGRP/SP release, measured by EIA.	Capsaicin	20-29	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	75-79
22080974-4	2012	TRPV1 activation by capsaicin and acidic solution (pH 5.1) induced colonic CGRP/SP release, measured by EIA.	Capsaicin	20-29	tachykinin 1	Mus musculus	80-82
22215506-0	2012	Differential effects of acute hypoxia on the activation of TRPV1 by capsaicin and acidic pH.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	59-64
22215506-4	2012	Such changes were also suggested from hypoxia- and capsaicin-induced Ca(2+) signals in TRPV1-expressing cells.	Capsaicin	51-60	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-92
22215506-13	2012	The differential effects of hypoxia on I (TRPV1,Cap) and I (TRPV1,Acid) suggested that the intracellular ROS increase might attenuate the pharmacological potency of capsaicin.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	42-47
22215506-13	2012	The differential effects of hypoxia on I (TRPV1,Cap) and I (TRPV1,Acid) suggested that the intracellular ROS increase might attenuate the pharmacological potency of capsaicin.	Capsaicin	165-174	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	60-65
20950828-1	2012	BACKGROUND: Capsaicin, a transient receptor potential vanilloid type 1 (TRPV1) agonist, was found to protect against myocardial and renal ischemia-reperfusion (IR) injury.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	25-70
20950828-1	2012	BACKGROUND: Capsaicin, a transient receptor potential vanilloid type 1 (TRPV1) agonist, was found to protect against myocardial and renal ischemia-reperfusion (IR) injury.	Capsaicin	12-21	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	72-77
24471060-4	2012	In the principle component analysis (PCA), PC1 (capsaicinoids) and PC2 (free sugar) were shown to represent 31.98% and 25.77% of the total variance, respectively.	Capsaicin	48-61	polycystin 1, transient receptor potential channel interacting	Homo sapiens	43-46
22209919-2	2012	Peripherally released 5HT induces thermal hyperalgesia, possibly via modulation of the transient receptor potential V1 (TRPV1) channel, which is gated by various noxious stimuli, including capsaicin.	Capsaicin	189-198	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-118
22178987-8	2012	Release of endogenous CGRP by capsaicin significantly reduced the basal overflow of NA, ir-NPY, and the electrically evoked sympathetic transmitter release.	Capsaicin	30-39	calcitonin-related polypeptide alpha	Rattus norvegicus	22-26
22209919-2	2012	Peripherally released 5HT induces thermal hyperalgesia, possibly via modulation of the transient receptor potential V1 (TRPV1) channel, which is gated by various noxious stimuli, including capsaicin.	Capsaicin	189-198	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	120-125
22209919-3	2012	We previously reported in vitro that 5HT increases calcium accumulation in the capsaicin-sensitive population of sensory neurons with a corresponding increase in proinflammatory neuropeptide release, and both are antagonized by pretreatment with 5HT(2A) and 5HT(3) antagonists, as well as the anti-migraine drug sumatriptan.	Capsaicin	79-88	5-hydroxytryptamine receptor 2A	Rattus norvegicus	246-252
22143339-2	2012	RECENT FINDINGS: A significant amount of research has recently focused on the role of capsaicin and its receptors (TRPV1 and VR1), which can be found on sensory c-fibers in human nasal mucosa and play a critical role in the development of nasal hyperresponsiveness to environmental factors.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	115-120
22200406-0	2012	Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: involvement of Ca(2+) influx.	Capsaicin	0-9	TNF superfamily member 10	Homo sapiens	21-26
22200406-0	2012	Capsaicin sensitizes TRAIL-induced apoptosis through Sp1-mediated DR5 up-regulation: involvement of Ca(2+) influx.	Capsaicin	0-9	TNF receptor superfamily member 10b	Homo sapiens	66-69
22200406-2	2012	The aim of this study is to evaluate the anti-cancer potential of capsaicin in TRAIL-induced cancer cell death.	Capsaicin	66-75	TNF superfamily member 10	Homo sapiens	79-84
22200406-3	2012	As indicated by assays that measure phosphatidylserine exposure, mitochondrial activity and activation of caspases, capsaicin potentiated TRAIL-resistant cells to lead to cell death.	Capsaicin	116-125	TNF superfamily member 10	Homo sapiens	138-143
22200406-4	2012	In addition, we found that capsaicin induces the cell surface expression of TRAIL receptor DR5, but not DR4 through the activation Sp1 on its promoter region.	Capsaicin	27-36	TNF superfamily member 10	Homo sapiens	76-81
22200406-4	2012	In addition, we found that capsaicin induces the cell surface expression of TRAIL receptor DR5, but not DR4 through the activation Sp1 on its promoter region.	Capsaicin	27-36	TNF receptor superfamily member 10b	Homo sapiens	91-94
22200406-5	2012	Furthermore, we investigated that capsaicin-induced DR5 expression and apoptosis are inhibited by calcium chelator or inhibitors for calmodulin-dependent protein kinase.	Capsaicin	34-43	TNF receptor superfamily member 10b	Homo sapiens	52-55
22200406-6	2012	Taken together, our data suggest that capsaicin sensitizes TRAIL-mediated HCC cell apoptosis by DR5 up-regulation via calcium influx-dependent Sp1 activation.	Capsaicin	38-47	TNF superfamily member 10	Homo sapiens	59-64
22200406-6	2012	Taken together, our data suggest that capsaicin sensitizes TRAIL-mediated HCC cell apoptosis by DR5 up-regulation via calcium influx-dependent Sp1 activation.	Capsaicin	38-47	TNF receptor superfamily member 10b	Homo sapiens	96-99
21753727-9	2012	CONCLUSION: A single 60-minute NGX-4010 treatment reduces PHN for up to 12 weeks regardless of concomitant systemic neuropathic pain medication use.	Capsaicin	31-39	carbamoyl-phosphate synthase 1	Homo sapiens	58-61
22143339-2	2012	RECENT FINDINGS: A significant amount of research has recently focused on the role of capsaicin and its receptors (TRPV1 and VR1), which can be found on sensory c-fibers in human nasal mucosa and play a critical role in the development of nasal hyperresponsiveness to environmental factors.	Capsaicin	86-95	transient receptor potential cation channel subfamily V member 1	Homo sapiens	125-128
22131384-6	2012	Furthermore, while in wild-type rod bipolar cells, TRPM1 could be activated by local application of capsaicin; in null cells, it did not.	Capsaicin	100-109	transient receptor potential cation channel, subfamily M, member 1	Mus musculus	51-56
22215714-1	2012	Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism.	Capsaicin	240-249	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	99-104
22215714-1	2012	Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism.	Capsaicin	240-249	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	226-231
22215714-1	2012	Other than efferent sympathetic innervation, the kidney has peptidergic afferent fibers expressing TRPV1 receptors and releasing substance P. We tested the hypothesis that stimulation of afferent renal nerve activity with the TRPV1 agonist capsaicin inhibits efferent renal sympathetic nerve activity tonically by a neurokinin 1 receptor-dependant mechanism.	Capsaicin	240-249	tachykinin receptor 1	Rattus norvegicus	316-337
22154816-2	2012	Activation of TRPV1 induces an influx of divalent and monovalent cations (i.e., Ca(2+), Na(+), and Mg(2+)) which are activated by capsaicin, heat, and acid.	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
22031765-4	2012	We showed previously that injection of NK-1 receptor antagonists into the RVM attenuated mechanical and heat hyperalgesia produced by intraplantar injection of capsaicin.	Capsaicin	160-169	tachykinin receptor 1	Homo sapiens	39-52
22031765-8	2012	Injection of the NK-1 antagonist L-733,060 did not alter evoked responses of ON or OFF cells but attenuated the capsaicin-evoked enhanced responses of ON cells to mechanical and heat stimuli with less of an effect on the enhanced inhibitory responses of OFF cells.	Capsaicin	112-121	tachykinin precursor 1	Homo sapiens	17-21
22221101-0	2012	Transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside Rg1 on capsaicin-induced interleukin-8 and prostaglandin E2 production in HaCaT cells.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
22221101-0	2012	Transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside Rg1 on capsaicin-induced interleukin-8 and prostaglandin E2 production in HaCaT cells.	Capsaicin	101-110	protein phosphatase 1 regulatory subunit 3A	Homo sapiens	94-97
22221101-0	2012	Transient receptor potential vanilloid-1 participates in the inhibitory effect of ginsenoside Rg1 on capsaicin-induced interleukin-8 and prostaglandin E2 production in HaCaT cells.	Capsaicin	101-110	C-X-C motif chemokine ligand 8	Homo sapiens	119-132
22221101-5	2012	KEY FINDINGS: The results showed that GRg1 blocked intracellular calcium by both capsaicin and proton activation in a TRPV1-dependent manner.	Capsaicin	81-90	transient receptor potential cation channel subfamily V member 1	Homo sapiens	118-123
22221101-6	2012	Furthermore, GRg1 inhibited the expression of COX-2 and NF-kappaB transcriptional activity induced by capsaicin in keratinocytes.	Capsaicin	102-111	prostaglandin-endoperoxide synthase 2	Homo sapiens	46-51
22221101-8	2012	More importantly, GRg1 dose-dependently inhibited capsaicin-induced PGE(2) and IL-8 secretion in HaCaT cells and HEK 293T-TRPV1 cells.	Capsaicin	50-59	C-X-C motif chemokine ligand 8	Homo sapiens	79-83
22460461-10	2012	Pharmacological block of mucosal CCK(1) receptor by tarazepide, vagotomy and capsaicin pretreatment abolished the effects of intravenous and intraduodenal apelin on P-BJ volume, protein and tryspin outputs.	Capsaicin	77-86	cholecystokinin	Rattus norvegicus	33-36
22460461-10	2012	Pharmacological block of mucosal CCK(1) receptor by tarazepide, vagotomy and capsaicin pretreatment abolished the effects of intravenous and intraduodenal apelin on P-BJ volume, protein and tryspin outputs.	Capsaicin	77-86	apelin	Rattus norvegicus	155-161
21855422-1	2012	TRPV1 expressing sensory neurons which have been considered to be largely associated with neurogenic inflammation were chemically denervated by capsaicin treatment in neonatal mice.	Capsaicin	144-153	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22130664-0	2012	Molecular cloning and functional characterization of Xenopus tropicalis frog transient receptor potential vanilloid 1 reveal its functional evolution for heat, acid, and capsaicin sensitivities in terrestrial vertebrates.	Capsaicin	170-179	transient receptor potential cation channel, subfamily V, member 1	Xenopus tropicalis	77-117
22264228-0	2012	Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-19
22264228-0	2012	Activation of TRPV1 by capsaicin induces functional kinin B(1) receptor in rat spinal cord microglia.	Capsaicin	23-32	bradykinin receptor B1	Rattus norvegicus	52-71
22264228-3	2012	METHODS: B(1)R expression (mRNA, protein and binding sites) was measured in cervical, thoracic and lumbar spinal cord in response to TRPV1 activation by systemic capsaicin (1-50 mg/kg, s.c) in rats pre-treated with TRPV1 antagonists (capsazepine or SB-366791), the antioxidant N-acetyl-L-cysteine (NAC), or vehicle.	Capsaicin	162-171	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	133-138
22264228-21	2012	The B(1)R fluorescent agonist was co-localized with an immunomarker of microglia (Iba-1) in spinal cord dorsal horn of capsaicin-treated rats.	Capsaicin	119-128	allograft inflammatory factor 1	Rattus norvegicus	82-87
22031786-0	2012	Circulating GLP-1 and CCK-8 reduce food intake by capsaicin-insensitive, nonvagal mechanisms.	Capsaicin	50-59	glucagon	Rattus norvegicus	12-17
22031786-6	2012	In fact, reduction of sucrose intake by our highest GLP-1 dose was enhanced in vagotomized and capsaicin-treated rats.	Capsaicin	95-104	glucagon	Rattus norvegicus	52-57
22031786-7	2012	Intravenous GLP-1 induced comparable increases of hindbrain c-Fos immunoreactivity in intact, capsaicin-treated, and vagotomized rats.	Capsaicin	94-103	glucagon	Rattus norvegicus	12-17
22031786-7	2012	Intravenous GLP-1 induced comparable increases of hindbrain c-Fos immunoreactivity in intact, capsaicin-treated, and vagotomized rats.	Capsaicin	94-103	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	60-65
22031786-8	2012	Plasma concentrations of active GLP-1 in capsaicin-treated rats did not differ from those of controls during the intravenous infusions.	Capsaicin	41-50	glucagon	Rattus norvegicus	32-37
21906661-1	2012	The transient receptor potential vanilloid type 1 channel (TRPV1; originally vanilloid receptor VR1) is activated in peripheral terminals of nociceptive fibers by noxious heat, low pH, and natural products such as capsaicin, the pungent ingredient of red-hot chilli peppers.	Capsaicin	214-223	transient receptor potential cation channel subfamily V member 1	Homo sapiens	59-64
21906661-1	2012	The transient receptor potential vanilloid type 1 channel (TRPV1; originally vanilloid receptor VR1) is activated in peripheral terminals of nociceptive fibers by noxious heat, low pH, and natural products such as capsaicin, the pungent ingredient of red-hot chilli peppers.	Capsaicin	214-223	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-99
22031786-9	2012	Finally, capsaicin treatment was not associated with altered GLP-1R mRNA in the brain, but nodose ganglia GLP-1R mRNA was significantly reduced in capsaicin-treated rats.	Capsaicin	147-156	glucagon-like peptide 1 receptor	Rattus norvegicus	106-112
22031786-10	2012	Although reduction of food intake by intraperitoneal cholecystokinin was abolished in vagotomized and capsaicin-treated rats, reduction of intake by intravenous cholecystokinin was only partially attenuated.	Capsaicin	102-111	cholecystokinin	Rattus norvegicus	53-68
22108615-0	2012	Disparate changes in the expression of transient receptor potential vanilloid type 1 receptor mRNA and protein in dorsal root ganglion neurons following local capsaicin treatment of the sciatic nerve in the rat.	Capsaicin	159-168	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	39-93
22108615-7	2012	In accord with these findings, quantitative RT-PCR revealed a marked and significant recovery in TRPV1 mRNA after perineural capsaicin but not after nerve transection.	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	97-102
22108615-9	2012	The present findings imply that the antinociceptive and anti-inflammatory effects of perineurally applied capsaicin involve distinct changes in neuronal TRPV1 mRNA expression and long-lasting alterations in (post)translational regulation.	Capsaicin	106-115	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	153-158
22155095-6	2012	We found that flupirtine inhibits in a concentration-dependent manner both basal and capsaicin-stimulated CGRP release from rat brainstem.	Capsaicin	85-94	calcitonin-related polypeptide alpha	Rattus norvegicus	106-110
22108615-1	2012	In situ hybridization, quantitative reverse transcription polymerase chain reaction (RT-PCR), immunohistochemistry, and Western blot analysis were applied to study the changes in expression of the major nociceptive ion channel transient receptor potential vanilloid type 1 receptor (TRPV1) after the perineural application of capsaicin or nerve transection.	Capsaicin	326-335	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	227-281
22108615-3	2012	After either transection or capsaicin treatment of the sciatic nerve, immunohistochemistry and Western blotting demonstrated a massive (up to 80%) decrease in the proportion of TRPV1-immunoreactive neurons and TRPV1 protein at all postoperative survival times.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	177-182
22108615-3	2012	After either transection or capsaicin treatment of the sciatic nerve, immunohistochemistry and Western blotting demonstrated a massive (up to 80%) decrease in the proportion of TRPV1-immunoreactive neurons and TRPV1 protein at all postoperative survival times.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	210-215
21998141-8	2012	In contrast, agonists for TRPV1 (capsaicin), TRPV3 (camphor), or TRPV4 (alpha-PDD) rarely induced an increase in the membrane conductance of PASMCs.	Capsaicin	33-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
22737633-3	2012	First studied in the dorsal root ganglia as the receptor for capsaicin, TRPV1 is now recognized to have a broader distribution and function within the central nervous system (CNS).	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
22300074-3	2012	Thyrotropin releasing hormone (TRH), or its stable TRH analog, RX-77368, injected at low doses into the cisterna magna or the dorsal motor nucleus (DMN) was the first peptide reported to protect the gastric mucosa against ethanol injury through stimulation of vagal cholinergic pathways, inducing the release of gastric prostaglandins/nitric oxide (NO) and the recruitment of efferent function of capsaicin sensitive afferent fibers containing calcitonin-gene related peptide (CGRP).	Capsaicin	397-406	thyrotropin releasing hormone	Homo sapiens	0-29
22127815-0	2012	The differential effect of intrathecal Nav1.8 blockers on the induction and maintenance of capsaicin- and peripheral ischemia-induced mechanical allodynia and thermal hyperalgesia.	Capsaicin	91-100	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	39-45
22127815-3	2012	We designed this study to investigate whether spinal Nav1.8 contributes to capsaicin-induced and peripheral ischemia-induced MA and TH.	Capsaicin	75-84	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	53-59
22127815-9	2012	Moreover, the capsaicin-induced increase of spinal Fos-immunoreactive cells was significantly diminished by pretreatment, but not posttreatment with Nav1.8 blockers.	Capsaicin	14-23	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	51-54
22089942-1	2012	Capsaicin is an agonist of transient receptor potential vanilloid type 1 (TRPV1), in which it can act as a neuronal stimulant and result in nociception.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Canis lupus familiaris	27-72
22089942-1	2012	Capsaicin is an agonist of transient receptor potential vanilloid type 1 (TRPV1), in which it can act as a neuronal stimulant and result in nociception.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Canis lupus familiaris	74-79
22300074-3	2012	Thyrotropin releasing hormone (TRH), or its stable TRH analog, RX-77368, injected at low doses into the cisterna magna or the dorsal motor nucleus (DMN) was the first peptide reported to protect the gastric mucosa against ethanol injury through stimulation of vagal cholinergic pathways, inducing the release of gastric prostaglandins/nitric oxide (NO) and the recruitment of efferent function of capsaicin sensitive afferent fibers containing calcitonin-gene related peptide (CGRP).	Capsaicin	397-406	thyrotropin releasing hormone	Homo sapiens	31-34
22182671-7	2012	Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8).	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
23365602-5	2012	Activation of TRPV1 by capsaicin resulted in degranulation.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	14-19
23365602-7	2012	We show that TRPV1 can functionally be expressed in the oocyte by (a) activation by capsaicin (K(1/2) = 1.1 muM), (b) activation by temperatures exceeding 42 C, (c) activation by reduced pH (from 7.4 to 6.2), and (d) inhibition by ruthenium red.	Capsaicin	84-93	transient receptor potential cation channel, subfamily V, member 1 S homeolog	Xenopus laevis	13-18
23037991-3	2012	Capsaicin is a highly selective agonist for the transient receptor potential channel vanilloid-receptor type 1 (TRPV1), which is expressed on central and peripheral terminals of nociceptive primary sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	48-110
23037991-3	2012	Capsaicin is a highly selective agonist for the transient receptor potential channel vanilloid-receptor type 1 (TRPV1), which is expressed on central and peripheral terminals of nociceptive primary sensory neurons.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
23037991-5	2012	Topical application of capsaicin at the peripheral terminal of TRPV1-expressing neurons superficially denervates the epidermis in humans in a highly selective manner and results in hypoalgesia.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
22182671-7	2012	Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8).	Capsaicin	79-88	transient receptor potential cation channel subfamily M member 8	Homo sapiens	60-65
22182671-7	2012	Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8).	Capsaicin	79-88	cannabinoid receptor 1	Homo sapiens	70-73
22182671-7	2012	Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8).	Capsaicin	79-88	latexin	Homo sapiens	93-96
22182671-7	2012	Even though both types of RB cells express TRPV1 as well as TRPM8 and CB1, the capsaicin (50 muM) (CAP)-induced Ca(2+) rise caused by TRPV1 activation was prompt and transient only in etoposide-resistant RB cells (n = 8).	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	134-139
22274646-5	2012	Capsazepine, a specific antagonist of TRPV1, completely blocked the capsaicin- and AM404-induced [Ca (2+)]i increases.	Capsaicin	68-77	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	38-43
21695504-4	2012	Capsaicin-induced calcitonin gene-related peptide release from peripheral sensory nerve terminals of isolated rat tracheae was significantly decreased by 2 muM CST and 100 nM SST, but concentration-response correlation was not found.	Capsaicin	0-9	cortistatin	Rattus norvegicus	160-163
22548186-0	2012	Capsaicin, a TRPV1 Ligand, Suppresses Bone Resorption by Inhibiting the Prostaglandin E Production of Osteoblasts, and Attenuates the Inflammatory Bone Loss Induced by Lipopolysaccharide.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	13-18
22375877-2	2012	In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 activities in human liver microsomes.	Capsaicin	56-65	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	95-101
22375877-2	2012	In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 activities in human liver microsomes.	Capsaicin	56-65	cytochrome P450 family 2 subfamily C member 9	Homo sapiens	103-109
22375877-2	2012	In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 activities in human liver microsomes.	Capsaicin	56-65	cytochrome P450 family 2 subfamily C member 19	Homo sapiens	111-118
22375877-2	2012	In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 activities in human liver microsomes.	Capsaicin	56-65	cytochrome P450 family 2 subfamily D member 6	Homo sapiens	120-126
22375877-2	2012	In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 activities in human liver microsomes.	Capsaicin	56-65	cytochrome P450 family 2 subfamily E member 1	Homo sapiens	128-134
22375877-2	2012	In this study, we examined the inhibitory potentials of capsaicin and dihydrocapsaicin against CYP1A2, CYP2C9, CYP2C19, CYP2D6, CYP2E1, and CYP3A4/5 activities in human liver microsomes.	Capsaicin	56-65	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	140-146
21975456-1	2012	Our previous work showed that nerve growth factor (NGF) increased the excitability of small-diameter capsaicin-sensitive sensory neurons by activating the p75 neurotrophin receptor and releasing sphingolipid-derived second messengers.	Capsaicin	101-110	nerve growth factor	Rattus norvegicus	30-49
21975456-1	2012	Our previous work showed that nerve growth factor (NGF) increased the excitability of small-diameter capsaicin-sensitive sensory neurons by activating the p75 neurotrophin receptor and releasing sphingolipid-derived second messengers.	Capsaicin	101-110	nerve growth factor	Rattus norvegicus	51-54
22302023-7	2012	Furthermore, painting with a threshold dose of capsaicin, which does not induce ear swelling in intact mice, caused marked ear swelling after painting the ear 5 times with FA, indicating that inflamed tissues after FA application are hypersensitive to various ligands of TRPV1 in mice.	Capsaicin	47-56	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	271-276
22548186-1	2012	Capsaicin, a transient receptor potential vanilloid type 1 (TRPV1) ligand, regulates nerve-related pain-sensitive signals, inflammation, and cancer growth.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	13-58
22548186-1	2012	Capsaicin, a transient receptor potential vanilloid type 1 (TRPV1) ligand, regulates nerve-related pain-sensitive signals, inflammation, and cancer growth.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	60-65
22548186-3	2012	This study examined the effects of capsaicin on inflammatory bone resorption and prostaglandin E (PGE) production induced by lipopolysaccharide (LPS) in vitro and on bone mass in LPS-treated mice in vivo.	Capsaicin	35-44	toll-like receptor 4	Mus musculus	145-148
22548186-4	2012	Capsaicin suppressed osteoclast formation, bone resorption, and PGE production induced by LPS in vitro.	Capsaicin	0-9	toll-like receptor 4	Mus musculus	90-93
22548186-5	2012	Capsaicin suppressed the expression of cyclooxygenase-2 (COX-2) and membrane-bound PGE synthase-1 (mPGES-1) mRNAs and PGE production induced by LPS in osteoblasts.	Capsaicin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	39-55
22548186-5	2012	Capsaicin suppressed the expression of cyclooxygenase-2 (COX-2) and membrane-bound PGE synthase-1 (mPGES-1) mRNAs and PGE production induced by LPS in osteoblasts.	Capsaicin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	57-62
22548186-5	2012	Capsaicin suppressed the expression of cyclooxygenase-2 (COX-2) and membrane-bound PGE synthase-1 (mPGES-1) mRNAs and PGE production induced by LPS in osteoblasts.	Capsaicin	0-9	prostaglandin E synthase	Mus musculus	99-106
22548186-5	2012	Capsaicin suppressed the expression of cyclooxygenase-2 (COX-2) and membrane-bound PGE synthase-1 (mPGES-1) mRNAs and PGE production induced by LPS in osteoblasts.	Capsaicin	0-9	toll-like receptor 4	Mus musculus	144-147
22548186-6	2012	Capsaicin may suppress PGE production by inhibiting the expression of COX-2 and mPGES-1 in osteoblasts and LPS-induced bone resorption by TRPV1 signals because osteoblasts express TRPV1.	Capsaicin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	70-75
22548186-6	2012	Capsaicin may suppress PGE production by inhibiting the expression of COX-2 and mPGES-1 in osteoblasts and LPS-induced bone resorption by TRPV1 signals because osteoblasts express TRPV1.	Capsaicin	0-9	prostaglandin E synthase	Mus musculus	80-87
22548186-6	2012	Capsaicin may suppress PGE production by inhibiting the expression of COX-2 and mPGES-1 in osteoblasts and LPS-induced bone resorption by TRPV1 signals because osteoblasts express TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	180-185
22548186-7	2012	LPS treatment markedly induced bone loss in the femur in mice, and capsaicin significantly restored the inflammatory bone loss induced by LPS in mice.	Capsaicin	67-76	toll-like receptor 4	Mus musculus	138-141
22548186-8	2012	TRPV1 ligands like capsaicin may therefore be potentially useful as clinical drugs targeting bone diseases associated with inflammatory bone resorption.	Capsaicin	19-28	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22375877-6	2012	Time-dependent inhibition of CYP3A4/5 by capsaicin was found.	Capsaicin	41-50	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	29-35
22375877-7	2012	After multiple administrations of capsaicin and dihydrocapsaicin (1, 4, and 10 mg/kg) to rats, chlorzoxazone 6-hydroxylase activity and the expression of CYP2E1 were increased in liver microsomes.	Capsaicin	34-43	cytochrome P450, family 2, subfamily e, polypeptide 1	Rattus norvegicus	154-160
21975456-12	2012	These results demonstrate that NGF leads to the activation of PKMzeta that ultimately enhances the capacity of small-diameter capsaicin-sensitive sensory neurons to fire APs through a PI3K-dependent signaling cascade.	Capsaicin	126-135	nerve growth factor	Rattus norvegicus	31-34
21994266-10	2012	Finally, we show that exogenous expression of TRPV1 in sensory neurons and exposure to capsaicin rescue sensory deficits of acd-1 tax-2(p694) mutants, suggesting that sensory deficits of these mutants are bypassed by increasing neuronal excitability.	Capsaicin	87-96	Uncharacterized protein	Caenorhabditis elegans	124-129
21994266-10	2012	Finally, we show that exogenous expression of TRPV1 in sensory neurons and exposure to capsaicin rescue sensory deficits of acd-1 tax-2(p694) mutants, suggesting that sensory deficits of these mutants are bypassed by increasing neuronal excitability.	Capsaicin	87-96	Cyclic nucleotide-binding domain-containing protein	Caenorhabditis elegans	130-135
22005042-1	2012	Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin.	Capsaicin	326-335	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-64
22005042-1	2012	Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin.	Capsaicin	326-335	transient receptor potential cation channel subfamily V member 1	Homo sapiens	66-71
22005042-1	2012	Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin.	Capsaicin	352-361	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-64
22005042-1	2012	Transient receptor potential cation channel subfamily V member 1 (TRPV1) is a high-conductance, nonselective cation channel strongly expressed in nociceptive primary afferent neurons of the peripheral nervous system and functions as a multimodal nociceptor gated by temperatures greater than 43 C, protons, and small-molecule vanilloid ligands such as capsaicin.	Capsaicin	352-361	transient receptor potential cation channel subfamily V member 1	Homo sapiens	66-71
22005042-4	2012	Here we show that the dihydropyridine derivative 4,5-diethyl-3-(2-methoxyethylthio)-2-methyl-6-phenyl-1,4-(+-)-dihydropyridine-3,5-dicarboxylate (MRS1477) behaves as a positive allosteric modulator of both proton and vanilloid activation of TRPV1.	Capsaicin	217-226	transient receptor potential cation channel subfamily V member 1	Homo sapiens	241-246
22510966-6	2012	The vasodilatation, but not vasoconstriction, in response to anandamide was markedly attenuated by capsazepine [selective antagonist for transient receptor potential vanilloid-1 (TRPV1)], pretreatment with capsaicin [calcitonin gene-related peptide (CGRP)ergic-nerve depletor], or cold-storage denervation.	Capsaicin	206-215	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	137-177
22510969-2	2012	In rat mesenteric vascular beds treated with capsaicin to eliminate calcitonin gene-related peptide (CGRP)ergic vasodilation and with active tone, PNS (1 - 4 Hz) induced only adrenergic nerve-mediated vasoconstriction.	Capsaicin	45-54	calcitonin-related polypeptide alpha	Rattus norvegicus	101-105
22113584-2	2012	Here we report that VR1 can regulate immunological events in the gut in response to its ligand Capsaicin (CP), a nutritional factor, the pungent component of chili peppers.	Capsaicin	95-104	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	20-23
22110945-3	2012	In the present study, we examined the c-Fos expression in spinal cord dorsal horn following injection of drugs associated with glutamate receptors with/without capsaicin into the hindpaw.	Capsaicin	160-169	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	38-43
22975058-4	2012	In fact, ghrelin"s action on feeding or GH secretion is abolished or attenuated in rats that have undergone vagotomy or treatment with capsaicin, a specific afferent neurotoxin.	Capsaicin	135-144	ghrelin and obestatin prepropeptide	Rattus norvegicus	9-16
22351087-7	2012	In contrast, capsaicin administration induced significant increases in the receptive field size and mechanical and cold responses of neurons located in superficial laminae of the C1/C2.	Capsaicin	13-22	complement C2	Rattus norvegicus	179-184
22110945-4	2012	The subcutaneous injection of capsaicin or glutamate remarkably evoked c-Fos expression in ipsilateral sides of spinal cord dorsal horn.	Capsaicin	30-39	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	71-76
22110945-5	2012	This capsaicin evoked increase of c-Fos expression was significantly prevented by concomitant administration of MK801, CNQX, and CPCCOEt.	Capsaicin	5-14	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	34-39
21928164-2	2012	Capsaicin is reported to trigger calcitonin gene-related peptide (CGRP) release through activation of transient receptor potential vanilloid subfamily member 1 (TRPV1) and produces beneficial effects on gastric mucosa.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	33-64
21928164-2	2012	Capsaicin is reported to trigger calcitonin gene-related peptide (CGRP) release through activation of transient receptor potential vanilloid subfamily member 1 (TRPV1) and produces beneficial effects on gastric mucosa.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	66-70
21928164-2	2012	Capsaicin is reported to trigger calcitonin gene-related peptide (CGRP) release through activation of transient receptor potential vanilloid subfamily member 1 (TRPV1) and produces beneficial effects on gastric mucosa.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	161-166
22905134-6	2012	Capsaicin, agonist of the transient receptor potential vanilloid 1 (TRPV1), a channel co-expressed with TRPA1 by airway sensory nerves, and acrolein or CS (TRPA1 agonists), or the neuropeptide substance P (SP), which is released from sensory nerve terminals by capsaicin, acrolein or CS), produced neurogenic inflammation in mouse airways.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	26-66
23144843-7	2012	Ca(2+) responses induced by capsaicin, a prototypical stimulus of transient receptor potential vanilloid subfamily member-1 (TRPV1) were diminished in NKCC1(-/-) TG neurons, but elevated under conditions of a lowered [Cl(-)](o) suggesting a Cl(-)-dependent amplification of capsaicin-induced responses.	Capsaicin	28-37	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	125-130
23144843-7	2012	Ca(2+) responses induced by capsaicin, a prototypical stimulus of transient receptor potential vanilloid subfamily member-1 (TRPV1) were diminished in NKCC1(-/-) TG neurons, but elevated under conditions of a lowered [Cl(-)](o) suggesting a Cl(-)-dependent amplification of capsaicin-induced responses.	Capsaicin	28-37	solute carrier family 12, member 2	Mus musculus	151-156
23144843-10	2012	In a behavioral paradigm, NKCC1(-/-) mice showed less avoidance of the aversive stimulus capsaicin.	Capsaicin	89-98	solute carrier family 12, member 2	Mus musculus	26-31
23236288-7	2012	Intriguingly, both of these mice exhibit pronounced hypersensitivity to noxious heat and capsaicin-induced pain, which directly mapped through PI3Kgamma kinase-dead knock-in mice to PI3Kgamma lipid kinase activity.	Capsaicin	89-98	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	143-152
23236288-7	2012	Intriguingly, both of these mice exhibit pronounced hypersensitivity to noxious heat and capsaicin-induced pain, which directly mapped through PI3Kgamma kinase-dead knock-in mice to PI3Kgamma lipid kinase activity.	Capsaicin	89-98	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma	Mus musculus	182-191
22962595-2	2012	In this study we hypothesized that the level of QX-314/capsaicin (QX-CAP)--induced blockade of nocifensive behavior could be used as an indirect in-vivo measurement of functional expression of TRPV1 channels.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	193-198
22905134-6	2012	Capsaicin, agonist of the transient receptor potential vanilloid 1 (TRPV1), a channel co-expressed with TRPA1 by airway sensory nerves, and acrolein or CS (TRPA1 agonists), or the neuropeptide substance P (SP), which is released from sensory nerve terminals by capsaicin, acrolein or CS), produced neurogenic inflammation in mouse airways.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	68-73
21868092-4	2011	Co-application of mAEA had a dual effect: nanomolar concentrations of mAEA (0.01 muM) significantly reduced capsaicin-evoked iCGRP release while concentrations &gt;= 1 muM mAEA had sensitizing effects.	Capsaicin	108-117	macrophage erythroblast attacher	Mus musculus	18-22
22815806-11	2012	Epicardial application of capsaicin increased superoxide anion level in PVN which was further enhanced by PVN pretreatment with ET-1.	Capsaicin	26-35	endothelin 1	Rattus norvegicus	128-132
23123709-4	2012	Studies showing that CGRP physiologically regulates skin inflammation using a CGRP antagonist, capsaicin-induced depletion model, RAMP1-deficient mice and mouse contact hypersensitivity (CHS) model have been reported.	Capsaicin	95-104	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	21-25
22025666-8	2011	Stimulation of the TRPv1 receptor by injection of capsaicin into the arterial supply of the hindlimb evoked significantly larger elevations in MAP and RSNA in SHR compared to WKY.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	19-24
21908651-4	2011	In vitro, activation of TRPV1 by the specific agonists capsaicin and resiniferatoxin dose-dependently increased cytosolic calcium and significantly reduced the accumulation of lipids in VSMC from C57BL/6J mice but not from TRPV1(-/-) mice.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	24-29
21908651-4	2011	In vitro, activation of TRPV1 by the specific agonists capsaicin and resiniferatoxin dose-dependently increased cytosolic calcium and significantly reduced the accumulation of lipids in VSMC from C57BL/6J mice but not from TRPV1(-/-) mice.	Capsaicin	55-64	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	223-228
21908651-7	2011	In vivo, long-term activation of TRPV1 by capsaicin for 24 weeks increased ABCA1 and reduced LRP1 expression in aorta from ApoE(-/-) mice on a high-fat diet.	Capsaicin	42-51	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	33-38
21908651-7	2011	In vivo, long-term activation of TRPV1 by capsaicin for 24 weeks increased ABCA1 and reduced LRP1 expression in aorta from ApoE(-/-) mice on a high-fat diet.	Capsaicin	42-51	ATP-binding cassette, sub-family A (ABC1), member 1	Mus musculus	75-80
21908651-7	2011	In vivo, long-term activation of TRPV1 by capsaicin for 24 weeks increased ABCA1 and reduced LRP1 expression in aorta from ApoE(-/-) mice on a high-fat diet.	Capsaicin	42-51	low density lipoprotein receptor-related protein 1	Mus musculus	93-97
21908651-7	2011	In vivo, long-term activation of TRPV1 by capsaicin for 24 weeks increased ABCA1 and reduced LRP1 expression in aorta from ApoE(-/-) mice on a high-fat diet.	Capsaicin	42-51	apolipoprotein E	Mus musculus	123-127
22514663-8	2012	A significant subset of neurons responded to capsaicin (CAP), a TRPV1 agonist, although neurons from C57BL/6 were 10-fold more sensitive to CAP than SD rats or BalbC mice, and a significantly smaller fraction of neurons from BalbC mice responded to CAP.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-69
22514663-8	2012	A significant subset of neurons responded to capsaicin (CAP), a TRPV1 agonist, although neurons from C57BL/6 were 10-fold more sensitive to CAP than SD rats or BalbC mice, and a significantly smaller fraction of neurons from BalbC mice responded to CAP.	Capsaicin	56-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	64-69
23196561-6	2012	The administration of capsaicin as an agonist stimulus of TRPV1, a warm temperature receptor, decreased the delay in swallowing reflex.	Capsaicin	22-31	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
22196363-7	2011	The capsaicin- and heat-sensitive ion channel TRPV1, expressed on a subpopulation of nociceptive neurons, has been shown to play an important role in inflammation-induced heat hypersensitivity.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	46-51
21930676-5	2011	In our experiments, sodium acetate (20 mm), which was used to induce intracellular acidosis, attenuated the capsaicin-evoked TRPV1 current (I(CAP)) in a reversible manner in whole-cell patch-clamp mode and shifted the concentration-response curve to the right.	Capsaicin	108-117	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	125-130
21868092-4	2011	Co-application of mAEA had a dual effect: nanomolar concentrations of mAEA (0.01 muM) significantly reduced capsaicin-evoked iCGRP release while concentrations &gt;= 1 muM mAEA had sensitizing effects.	Capsaicin	108-117	macrophage erythroblast attacher	Mus musculus	70-74
21868092-4	2011	Co-application of mAEA had a dual effect: nanomolar concentrations of mAEA (0.01 muM) significantly reduced capsaicin-evoked iCGRP release while concentrations &gt;= 1 muM mAEA had sensitizing effects.	Capsaicin	108-117	macrophage erythroblast attacher	Mus musculus	70-74
21962912-4	2011	Additionally, the agonists allyl isothiocyanate (TRPA1) and capsaicin (TRPV1) induce a differential secretion pattern of the eicosanoids PGE(2) and LTB(4) in human dermal fibroblasts and keratinocytes, which was also detectable invivo, analyzing suction blister fluid at various times after short-term topical application.	Capsaicin	60-69	transient receptor potential cation channel subfamily V member 1	Homo sapiens	71-76
21868092-7	2011	CB1-/- and CB1/CB2 double -/- mice equally displayed increased sensitivity to mAEA (100 muM) and a sensitizing effect to capsaicin, in contrast to wildtypes.	Capsaicin	121-130	cannabinoid receptor 1 (brain)	Mus musculus	0-3
21868092-7	2011	CB1-/- and CB1/CB2 double -/- mice equally displayed increased sensitivity to mAEA (100 muM) and a sensitizing effect to capsaicin, in contrast to wildtypes.	Capsaicin	121-130	cannabinoid receptor 1 (brain)	Mus musculus	11-14
21250977-0	2011	CCAAT/ enhancer-binding protein beta activation by capsaicin contributes to the regulation of CYP1A1 expression, mediated by the aryl hydrocarbon receptor.	Capsaicin	51-60	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	0-36
22509539-1	2011	OBJECTIVE: To investigate the role of dietary capsaicin in activating transient receptor potential vanilloid 1 (TRPV1) and thus influencing the vascular dysfunction mediated by high-fat diet and the potential mechanisms.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	70-110
22509539-1	2011	OBJECTIVE: To investigate the role of dietary capsaicin in activating transient receptor potential vanilloid 1 (TRPV1) and thus influencing the vascular dysfunction mediated by high-fat diet and the potential mechanisms.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	112-117
22509539-7	2011	Dietary capsaicin down-regulated the expression of RhoA and Rho kinase but up-regulated the expression of Kv1.4 in aorta in mice fed with normal or high fat diet (all P &lt; 0.05).	Capsaicin	8-17	ras homolog family member A	Mus musculus	51-55
22509539-7	2011	Dietary capsaicin down-regulated the expression of RhoA and Rho kinase but up-regulated the expression of Kv1.4 in aorta in mice fed with normal or high fat diet (all P &lt; 0.05).	Capsaicin	8-17	Rho-associated coiled-coil containing protein kinase 2	Mus musculus	60-70
22509539-7	2011	Dietary capsaicin down-regulated the expression of RhoA and Rho kinase but up-regulated the expression of Kv1.4 in aorta in mice fed with normal or high fat diet (all P &lt; 0.05).	Capsaicin	8-17	potassium voltage-gated channel, shaker-related subfamily, member 4	Mus musculus	106-111
21911503-1	2011	The capsaicin-, heat-, and proton-activated ion channel TRPV1, a member of the transient receptor potential cation channel family is a polymodal nociceptor.	Capsaicin	4-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
21911503-3	2011	Antagonists which block TRPV1 activation by capsaicin, heat, and protons were developed by a number of pharmaceutical companies.	Capsaicin	44-53	transient receptor potential cation channel subfamily V member 1	Homo sapiens	24-29
21889971-0	2011	Spinal glycinergic and GABAergic neurons expressing C-fos after capsaicin stimulation are increased in rats with contralateral neuropathic pain.	Capsaicin	64-73	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	52-57
21889971-2	2011	We have investigated this phenomenon by studying the activation pattern (using C-fos labeling) of spinal glycinergic and GABAergic (Gly/GABA) neurons after capsaicin injection in the ipsilateral hind paw of rats that were preconditioned with an acute or chronic pain stimulus in the contralateral hind paw or rats that were not preconditioned (control).	Capsaicin	156-165	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	79-84
21889971-5	2011	We found that after capsaicin injection in rats preconditioned with CFA inflammation (4 days), sham-SNI or with SNI neuropathic pain, the numbers (27 +- 3, 21 +- 2, and 21 +- 2, respectively) and percentages (55% +- 4, 43% +- 2, and 42% +- 2, respectively) of C-fos activated neurons that were Gly/GABA increased significantly as compared with control (10 +- 1 and 25% +- 2).	Capsaicin	20-29	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	260-265
22094702-9	2011	Purified MitTx elicits robust pain-related behaviour in mice by activation of ASIC1 channels on capsaicin-sensitive nerve fibres.	Capsaicin	96-105	acid-sensing (proton-gated) ion channel 1	Mus musculus	78-83
27721335-3	2011	This study presents evidence for activation and translocation of the PKC betaII isoform as a signaling event in nociception mediated by activation of TRPV1 by capsaicin.	Capsaicin	159-168	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	150-155
27721335-5	2011	We also show capsaicin-induced translocation in Chinese Hamster Ovarian (CHO) cells co-transfected with TRPV1 and PKCbetaII-EGFP, but not in CHO cells expressing PKCbetaII-EGFP alone.	Capsaicin	13-22	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	104-109
27721335-7	2011	In addition PMA-induced sensitization of TRPV1 to capsaicin response in DRG neurons was attenuated by PKCbetaII blocker CGP 53353.	Capsaicin	50-59	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	41-46
27721335-8	2011	Capsaicin response via TRPV1 in the DRG neurons was confirmed by TRPV1 antagonist AMG 9810.	Capsaicin	0-9	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	23-28
27721335-8	2011	Capsaicin response via TRPV1 in the DRG neurons was confirmed by TRPV1 antagonist AMG 9810.	Capsaicin	0-9	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	65-70
21250977-13	2011	CONCLUSIONS AND IMPLICATIONS: Capsaicin alone weakly induced CYP1A1 expression, and 3-MC-induced CYP1A1 levels were suppressed by capsaicin.	Capsaicin	30-39	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	61-67
21250977-13	2011	CONCLUSIONS AND IMPLICATIONS: Capsaicin alone weakly induced CYP1A1 expression, and 3-MC-induced CYP1A1 levels were suppressed by capsaicin.	Capsaicin	130-139	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	97-103
21250977-14	2011	Activation of C/EBPbeta and inhibition of 3-MC-induced AhR transactivation by capsaicin contributed to the suppression of CYP1A1 expression.	Capsaicin	78-87	aryl-hydrocarbon receptor	Mus musculus	55-58
21250977-14	2011	Activation of C/EBPbeta and inhibition of 3-MC-induced AhR transactivation by capsaicin contributed to the suppression of CYP1A1 expression.	Capsaicin	78-87	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	122-128
21250977-15	2011	Capsaicin has a potential chemopreventive effect through inhibiting induction of CYP1A1 by poly aryl hydrocarbons.	Capsaicin	0-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	81-87
21250977-0	2011	CCAAT/ enhancer-binding protein beta activation by capsaicin contributes to the regulation of CYP1A1 expression, mediated by the aryl hydrocarbon receptor.	Capsaicin	51-60	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	94-100
21250977-0	2011	CCAAT/ enhancer-binding protein beta activation by capsaicin contributes to the regulation of CYP1A1 expression, mediated by the aryl hydrocarbon receptor.	Capsaicin	51-60	aryl-hydrocarbon receptor	Mus musculus	129-154
21250977-2	2011	The influence of capsaicin on cytochrome P450 (CYP) 1A1, which is involved in metabolism of carcinogens, and the underlying mechanisms remain unclear.	Capsaicin	17-26	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	30-55
21250977-3	2011	Here, we examined the effect of capsaicin on CYP1A1 expression in mouse hepatoma cells.	Capsaicin	32-41	cytochrome P450 family 1 subfamily A member 1	Homo sapiens	45-51
21735133-0	2011	Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2), enhances capsaicin-induced inhibition of gastric cancer cell growth.	Capsaicin	73-82	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	19-48
21735133-0	2011	Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2), enhances capsaicin-induced inhibition of gastric cancer cell growth.	Capsaicin	73-82	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	50-54
21250977-5	2011	Effects of capsaicin on CYP1A1 levels were determined by analysing mRNA expression, transcription activity and protein expression.	Capsaicin	11-20	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	24-30
21735133-0	2011	Down-regulation of tumor-associated NADH oxidase, tNOX (ENOX2), enhances capsaicin-induced inhibition of gastric cancer cell growth.	Capsaicin	73-82	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	56-61
21859833-0	2011	Inhibition of chronic pancreatitis and pancreatic intraepithelial neoplasia (PanIN) by capsaicin in LSL-KrasG12D/Pdx1-Cre mice.	Capsaicin	87-96	pancreatic and duodenal homeobox 1	Mus musculus	113-117
21250977-7	2011	KEY RESULTS: Capsaicin alone slightly induced CYP1A1 activity, mRNA expression, protein level and promoter activity.	Capsaicin	13-22	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	46-52
21859833-2	2011	Extensive studies indicate that capsaicin is a cancer-suppressing agent via blocking the activities of several signal transduction pathways including nuclear factor-kappaB, activator protein-1 and signal transducer and activator of transcription 3.	Capsaicin	32-41	signal transducer and activator of transcription 3	Mus musculus	197-247
21859833-4	2011	In the present study, the effect of capsaicin on pancreatitis and pancreatic intraepithelial neoplasia (PanIN) was determined in a mutant Kras-driven and caerulein-induced pancreatitis-associated carcinogenesis in LSL-Kras(G12D)/Pdx1-Cre mice.	Capsaicin	36-45	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	138-142
21859833-13	2011	capsaicin significantly reduced proliferating cell nuclear antigen-labeled cell proliferation and suppressed phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun as well blocked Hedgehog/GLI pathway activation.	Capsaicin	0-9	mitogen-activated protein kinase 1	Mus musculus	128-165
21859833-13	2011	capsaicin significantly reduced proliferating cell nuclear antigen-labeled cell proliferation and suppressed phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun as well blocked Hedgehog/GLI pathway activation.	Capsaicin	0-9	mitogen-activated protein kinase 1	Mus musculus	167-170
21735133-5	2011	Here, we examined the effect of capsaicin on SNU-1 and TMC-1 gastric cancer cells and found differing outcomes between the two cell lines.	Capsaicin	32-41	transmembrane channel like 1	Homo sapiens	55-60
21735133-6	2011	Our results show that capsaicin induced significant cytotoxicity with increases in oxidative stress, PARP cleavage, and apoptosis in sensitive SNU-1 cells.	Capsaicin	22-31	collagen type XI alpha 2 chain	Homo sapiens	101-105
21735133-7	2011	In contrast, TMC-1 cells were much less sensitive to capsaicin, exhibiting low cytotoxicity and very little apoptosis in response to capsaicin treatment.	Capsaicin	53-62	transmembrane channel like 1	Homo sapiens	13-18
21250977-8	2011	Treatment with transient receptor potential vanilloid type-1 receptor (TRPV1) or aryl hydrocarbon receptor (AhR) antagonist decreased induction of CYP1A1 expression by capsaicin.	Capsaicin	168-177	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	15-69
21735133-7	2011	In contrast, TMC-1 cells were much less sensitive to capsaicin, exhibiting low cytotoxicity and very little apoptosis in response to capsaicin treatment.	Capsaicin	133-142	transmembrane channel like 1	Homo sapiens	13-18
21735133-8	2011	Capsaicin-induced apoptosis in SNU-1 cells was associated with down-regulation of tumor-associated NADH oxidase (tNOX) mRNA and protein.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	82-111
21859833-13	2011	capsaicin significantly reduced proliferating cell nuclear antigen-labeled cell proliferation and suppressed phosphorylation of extracellular signal-regulated kinase (ERK) and c-Jun as well blocked Hedgehog/GLI pathway activation.	Capsaicin	0-9	jun proto-oncogene	Mus musculus	176-181
21859833-14	2011	These results indicate that capsaicin could be a promising agent for the chemoprevention of pancreatic carcinogenesis, possibly via inhibiting pancreatitis and mutant Kras-led ERK activation.	Capsaicin	28-37	Kirsten rat sarcoma viral oncogene homolog	Mus musculus	167-171
21735133-8	2011	Capsaicin-induced apoptosis in SNU-1 cells was associated with down-regulation of tumor-associated NADH oxidase (tNOX) mRNA and protein.	Capsaicin	0-9	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	113-117
21859833-14	2011	These results indicate that capsaicin could be a promising agent for the chemoprevention of pancreatic carcinogenesis, possibly via inhibiting pancreatitis and mutant Kras-led ERK activation.	Capsaicin	28-37	mitogen-activated protein kinase 1	Mus musculus	176-179
21250977-8	2011	Treatment with transient receptor potential vanilloid type-1 receptor (TRPV1) or aryl hydrocarbon receptor (AhR) antagonist decreased induction of CYP1A1 expression by capsaicin.	Capsaicin	168-177	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	71-76
21735133-10	2011	We further showed that tNOX-knockdown sensitized TMC-1 cells to capsaicin-induced apoptosis and G1 phase accumulation, and led to decreased cell growth, demonstrating that tNOX is essential for cancer cell growth.	Capsaicin	64-73	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	23-27
21250977-8	2011	Treatment with transient receptor potential vanilloid type-1 receptor (TRPV1) or aryl hydrocarbon receptor (AhR) antagonist decreased induction of CYP1A1 expression by capsaicin.	Capsaicin	168-177	aryl-hydrocarbon receptor	Mus musculus	81-106
21735133-10	2011	We further showed that tNOX-knockdown sensitized TMC-1 cells to capsaicin-induced apoptosis and G1 phase accumulation, and led to decreased cell growth, demonstrating that tNOX is essential for cancer cell growth.	Capsaicin	64-73	transmembrane channel like 1	Homo sapiens	49-54
21735133-10	2011	We further showed that tNOX-knockdown sensitized TMC-1 cells to capsaicin-induced apoptosis and G1 phase accumulation, and led to decreased cell growth, demonstrating that tNOX is essential for cancer cell growth.	Capsaicin	64-73	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	172-176
21250977-8	2011	Treatment with transient receptor potential vanilloid type-1 receptor (TRPV1) or aryl hydrocarbon receptor (AhR) antagonist decreased induction of CYP1A1 expression by capsaicin.	Capsaicin	168-177	aryl-hydrocarbon receptor	Mus musculus	108-111
21735133-11	2011	Collectively, these results indicate that capsaicin induces divergent effects of the growth of gastric cancer cells that parallel its effects on tNOX expression, and demonstrate that forced tNOX down-regulation restored capsaicin-induced growth inhibition in TMC-1 cells.	Capsaicin	42-51	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	145-149
21250977-8	2011	Treatment with transient receptor potential vanilloid type-1 receptor (TRPV1) or aryl hydrocarbon receptor (AhR) antagonist decreased induction of CYP1A1 expression by capsaicin.	Capsaicin	168-177	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	147-153
21735133-11	2011	Collectively, these results indicate that capsaicin induces divergent effects of the growth of gastric cancer cells that parallel its effects on tNOX expression, and demonstrate that forced tNOX down-regulation restored capsaicin-induced growth inhibition in TMC-1 cells.	Capsaicin	42-51	transmembrane channel like 1	Homo sapiens	259-264
21735133-11	2011	Collectively, these results indicate that capsaicin induces divergent effects of the growth of gastric cancer cells that parallel its effects on tNOX expression, and demonstrate that forced tNOX down-regulation restored capsaicin-induced growth inhibition in TMC-1 cells.	Capsaicin	220-229	ecto-NOX disulfide-thiol exchanger 2	Homo sapiens	190-194
21250977-9	2011	Additionally, capsaicin significantly inhibited 3-MC-induced CYP1A1 mRNA and protein level and xenobiotic response element-luciferase activity.	Capsaicin	14-23	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	61-67
21735133-11	2011	Collectively, these results indicate that capsaicin induces divergent effects of the growth of gastric cancer cells that parallel its effects on tNOX expression, and demonstrate that forced tNOX down-regulation restored capsaicin-induced growth inhibition in TMC-1 cells.	Capsaicin	220-229	transmembrane channel like 1	Homo sapiens	259-264
21250977-10	2011	Capsaicin also inhibited 3-MC-induced AhR transactivation and nuclear localization of AhRs.	Capsaicin	0-9	aryl-hydrocarbon receptor	Mus musculus	38-41
21250977-11	2011	Moreover, capsaicin increased Ca(2+) /calmodulin (CaM)-dependent protein kinase (CaMK) and CCAAT/ enhancer-binding protein beta (C/EBPbeta) activation, downstream of TRPV1 receptors.	Capsaicin	10-19	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	91-127
21250977-11	2011	Moreover, capsaicin increased Ca(2+) /calmodulin (CaM)-dependent protein kinase (CaMK) and CCAAT/ enhancer-binding protein beta (C/EBPbeta) activation, downstream of TRPV1 receptors.	Capsaicin	10-19	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	129-138
21250977-11	2011	Moreover, capsaicin increased Ca(2+) /calmodulin (CaM)-dependent protein kinase (CaMK) and CCAAT/ enhancer-binding protein beta (C/EBPbeta) activation, downstream of TRPV1 receptors.	Capsaicin	10-19	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	166-171
21250977-12	2011	Capsaicin-induced C/EBPbeta activation inhibited induction of CYP1A1 mRNA and protein by 3-MC.	Capsaicin	0-9	CCAAT/enhancer binding protein (C/EBP), beta	Mus musculus	18-27
21250977-12	2011	Capsaicin-induced C/EBPbeta activation inhibited induction of CYP1A1 mRNA and protein by 3-MC.	Capsaicin	0-9	cytochrome P450, family 1, subfamily a, polypeptide 1	Mus musculus	62-68
21981454-1	2011	AIM: Nasal transient receptor potential vanilloid 1 (TRPV1) stimulation with capsaicin produces serous and mucinous secretion in the human nasal airway.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	11-51
21981454-1	2011	AIM: Nasal transient receptor potential vanilloid 1 (TRPV1) stimulation with capsaicin produces serous and mucinous secretion in the human nasal airway.	Capsaicin	77-86	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-58
21981454-9	2011	Lavage fluids obtained after challenge with capsaicin and mustard oil indicated increased levels of MUC5B, whereas MUC5AC was unaffected.	Capsaicin	44-53	mucin 5B, oligomeric mucus/gel-forming	Homo sapiens	100-105
21867704-5	2011	The TRPV1 agonist capsaicin (CAPS, 1 muM) and the TRPA1 agonist allyl isothiocyanate (AITC, 30 muM), elicited excitatory effects in bladder strips, increasing basal tone and amplitude of phasic bladder contractions (PBC).	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
21573941-2	2011	AIM: As capsaicin contained in red pepper is able to desensitize the TRPV(1) fibres, we evaluated whether the red pepper oral administration can decrease the symptoms of visceral hypersensitivity in IBS patients.	Capsaicin	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	69-76
22082421-0	2011	Increase of capsaicin-induced trigeminal Fos-like immunoreactivity by 5-HT(7) receptors.	Capsaicin	12-21	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	41-44
22082421-8	2011	RESULTS: Capsaicin but not its vehicle induced Fos-like immunoreactivity within laminae I and II of trigeminal nucleus caudalis.	Capsaicin	9-18	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	47-50
22082421-10	2011	Interestingly, capsaicin-induced Fos-like immunoreactivity was abolished by SB-656104 pretreatment thus suggesting involvement of endogenous 5-HT.	Capsaicin	15-24	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	33-36
21829089-6	2011	Using the YO-PRO-1 based fluorescent dye uptake assay, we found that cap-ET effectively triggered Ca(2+) dependent desensitization of TRPV1 when the receptor was pre-sensitized with the surrogate oxidative chemical phenylarsine oxide (PAO), suggesting an alternative use of permanently charged cationic capsaicinoids in differential neuronal silencing.	Capsaicin	303-316	lamin A/C	Homo sapiens	13-18
21829089-6	2011	Using the YO-PRO-1 based fluorescent dye uptake assay, we found that cap-ET effectively triggered Ca(2+) dependent desensitization of TRPV1 when the receptor was pre-sensitized with the surrogate oxidative chemical phenylarsine oxide (PAO), suggesting an alternative use of permanently charged cationic capsaicinoids in differential neuronal silencing.	Capsaicin	303-316	transient receptor potential cation channel subfamily V member 1	Homo sapiens	134-139
21867704-5	2011	The TRPV1 agonist capsaicin (CAPS, 1 muM) and the TRPA1 agonist allyl isothiocyanate (AITC, 30 muM), elicited excitatory effects in bladder strips, increasing basal tone and amplitude of phasic bladder contractions (PBC).	Capsaicin	18-27	calcium dependent secretion activator	Rattus norvegicus	29-40
21867704-5	2011	The TRPV1 agonist capsaicin (CAPS, 1 muM) and the TRPA1 agonist allyl isothiocyanate (AITC, 30 muM), elicited excitatory effects in bladder strips, increasing basal tone and amplitude of phasic bladder contractions (PBC).	Capsaicin	18-27	latexin	Homo sapiens	37-40
21432926-5	2011	Of the herbals tested, Pipaye (Folium Eriobotryae) extracts, especially the 50% ethanol extract, showed the highest activity for the suppression of TRPV1 activation by its agonist capsaicin.	Capsaicin	180-189	transient receptor potential cation channel subfamily V member 1	Homo sapiens	148-153
21663483-0	2011	Suppression of tumor necrosis factor-alpha-induced nuclear factor kappaB activation and aromatase activity by capsaicin and its analog capsazepine.	Capsaicin	110-119	tumor necrosis factor	Homo sapiens	15-42
21663483-4	2011	Capsaicin and capsazepine blocked TNFalpha-induced NFkappaB activation in a dose-dependent manner with 50% inhibitory concentration (IC(50)) values of 0.68 and 4.2 muM, respectively.	Capsaicin	0-9	tumor necrosis factor	Homo sapiens	34-42
21663483-4	2011	Capsaicin and capsazepine blocked TNFalpha-induced NFkappaB activation in a dose-dependent manner with 50% inhibitory concentration (IC(50)) values of 0.68 and 4.2 muM, respectively.	Capsaicin	0-9	nuclear factor kappa B subunit 1	Homo sapiens	51-59
21663483-4	2011	Capsaicin and capsazepine blocked TNFalpha-induced NFkappaB activation in a dose-dependent manner with 50% inhibitory concentration (IC(50)) values of 0.68 and 4.2 muM, respectively.	Capsaicin	0-9	latexin	Homo sapiens	164-167
21663483-8	2011	The highly conserved residues for capsaicin and capsazepine binding with NFkappaB p50 were Ser299 and Ile278 (H-bond 2.81A) and with NFkappaB p100 were Ser6, Arg82, Val86, Arg90 (H-bond 2.89A), Gly4, and Ser2 (H-bond 2.81A).	Capsaicin	34-43	nuclear factor kappa B subunit 1	Homo sapiens	73-81
21663483-8	2011	The highly conserved residues for capsaicin and capsazepine binding with NFkappaB p50 were Ser299 and Ile278 (H-bond 2.81A) and with NFkappaB p100 were Ser6, Arg82, Val86, Arg90 (H-bond 2.89A), Gly4, and Ser2 (H-bond 2.81A).	Capsaicin	34-43	nuclear factor kappa B subunit 1	Homo sapiens	82-85
21663483-8	2011	The highly conserved residues for capsaicin and capsazepine binding with NFkappaB p50 were Ser299 and Ile278 (H-bond 2.81A) and with NFkappaB p100 were Ser6, Arg82, Val86, Arg90 (H-bond 2.89A), Gly4, and Ser2 (H-bond 2.81A).	Capsaicin	34-43	nuclear factor kappa B subunit 1	Homo sapiens	133-141
21663483-8	2011	The highly conserved residues for capsaicin and capsazepine binding with NFkappaB p50 were Ser299 and Ile278 (H-bond 2.81A) and with NFkappaB p100 were Ser6, Arg82, Val86, Arg90 (H-bond 2.89A), Gly4, and Ser2 (H-bond 2.81A).	Capsaicin	34-43	jagged canonical Notch ligand 2	Homo sapiens	91-95
21432926-7	2011	Thus the inhibition of capsaicin elicited Ca-flux in TRPV1 cells by Pipaye is largely due to desensitization of the receptor.	Capsaicin	23-32	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-58
22019732-1	2011	Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin.	Capsaicin	229-238	arginine vasopressin receptor 1A	Mus musculus	91-97
21892726-1	2011	TRPV1 is a Ca(2+) permeable cation channel gated by multiple stimuli including noxious heat, capsaicin, protons, and extracellular cations.	Capsaicin	93-102	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
21892726-2	2011	In this paper, we show that Ca(2+) causes a concentration and voltage-dependent decrease in the capsaicin-gated TRPV1 single-channel conductance.	Capsaicin	96-105	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
21904821-1	2011	We studied the inhibitory effects of transient receptor potential vanilloid-1 (TRPV1) activation by capsaicin on low-voltage-activated (LVA, T-type) Ca(2+) channel and high-voltage-activated (HVA; L, N, P/Q, R) currents in rat DRG sensory neurons, as a potential mechanism underlying capsaicin-induced analgesia.	Capsaicin	100-109	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	37-77
21904821-1	2011	We studied the inhibitory effects of transient receptor potential vanilloid-1 (TRPV1) activation by capsaicin on low-voltage-activated (LVA, T-type) Ca(2+) channel and high-voltage-activated (HVA; L, N, P/Q, R) currents in rat DRG sensory neurons, as a potential mechanism underlying capsaicin-induced analgesia.	Capsaicin	100-109	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	79-84
21904821-6	2011	The percentage of T-type and HVA channel inhibition was prevented by replacing Ca(2+) with Ba(2+) during capsaicin application or applying high doses of intracellular BAPTA (20 mM), suggesting that TRPV1-mediated inhibition of T-type and HVA channels is Ca(2+)-dependent and likely confined to membrane nano-microdomains.	Capsaicin	105-114	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	198-203
21852608-0	2011	Activation of transient receptor potential vanilloid 1 by dietary capsaicin delays the onset of stroke in stroke-prone spontaneously hypertensive rats.	Capsaicin	66-75	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	14-54
21852608-3	2011	We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	111-151
21852608-3	2011	We test the hypothesis that chronic dietary capsaicin can prevent stroke through activation of cerebrovascular transient receptor potential vanilloid 1 (TRPV1) channels in stroke-prone spontaneously hypertensive rats (SHRsp).	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	153-158
21852608-9	2011	Inhibition of eNOS using N(G)-nitro-L-arginine methyl ester, removal of endothelium, or mutant TRPV1 significantly reduced capsaicin-induced endothelium-dependent relaxation of basilar arteries in mice.	Capsaicin	123-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	95-100
21852608-15	2011	CONCLUSIONS: Activation of TRPV1 channels by dietary capsaicin mediated increases in phosphorylation of eNOS and could represent a novel target for dietary intervention of stroke.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	27-32
22019732-1	2011	Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin.	Capsaicin	229-238	arginine vasopressin receptor 1A	Mus musculus	122-145
22019732-1	2011	Quantitative trait locus mapping of chemical/inflammatory pain in the mouse identified the Avpr1a gene, which encodes the vasopressin-1A receptor (V1AR), as being responsible for strain-dependent pain sensitivity to formalin and capsaicin.	Capsaicin	229-238	arginine vasopressin receptor 1A	Mus musculus	147-151
22019732-2	2011	A genetic association study in humans revealed the influence of a single nucleotide polymorphism (rs10877969) in AVPR1A on capsaicin pain levels, but only in male subjects reporting stress at the time of testing.	Capsaicin	123-132	arginine vasopressin receptor 1A	Homo sapiens	113-119
21474433-2	2011	Application of capsaicin (100 muM) attenuated vectorial anion transport, estimated as short-circuit currents (I(SC)), before and after stimulation by forskolin (10 muM) with concomitant reduction of cytosolic cyclic AMP (cAMP) levels.	Capsaicin	15-24	latexin	Homo sapiens	30-33
22016541-8	2011	Strikingly, NPD1 potently inhibits capsaicin-induced TRPV1 current (IC(50) = 0.4 nm) in dissociated dorsal root ganglion neurons, and this IC(50) is   500 times lower than that of AMG9810, a commonly used TRPV1 antagonist.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	53-58
22016541-8	2011	Strikingly, NPD1 potently inhibits capsaicin-induced TRPV1 current (IC(50) = 0.4 nm) in dissociated dorsal root ganglion neurons, and this IC(50) is   500 times lower than that of AMG9810, a commonly used TRPV1 antagonist.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	205-210
21474433-2	2011	Application of capsaicin (100 muM) attenuated vectorial anion transport, estimated as short-circuit currents (I(SC)), before and after stimulation by forskolin (10 muM) with concomitant reduction of cytosolic cyclic AMP (cAMP) levels.	Capsaicin	15-24	latexin	Homo sapiens	164-167
21474433-2	2011	Application of capsaicin (100 muM) attenuated vectorial anion transport, estimated as short-circuit currents (I(SC)), before and after stimulation by forskolin (10 muM) with concomitant reduction of cytosolic cyclic AMP (cAMP) levels.	Capsaicin	15-24	cathelicidin antimicrobial peptide	Homo sapiens	221-225
21474433-3	2011	The capsaicin-induced inhibition of I(SC) was also observed in the response to 8-bromo-cAMP (1 mM, a cell-permeable cAMP analog) and 3-isobutyl-1-methylxanthine (1 mM, an inhibitor of phosphodiesterases).	Capsaicin	4-13	cathelicidin antimicrobial peptide	Homo sapiens	87-91
21474433-3	2011	The capsaicin-induced inhibition of I(SC) was also observed in the response to 8-bromo-cAMP (1 mM, a cell-permeable cAMP analog) and 3-isobutyl-1-methylxanthine (1 mM, an inhibitor of phosphodiesterases).	Capsaicin	4-13	cathelicidin antimicrobial peptide	Homo sapiens	116-120
21474433-4	2011	The capsaicin-induced inhibition of I(SC) was attributed to suppression of bumetanide (an inhibitor of the basolateral Na(+)-K(+)-2 Cl(-) cotransporter 1)- and 4,4"-dinitrostilbene-2,2"-disulfonic acid (an inhibitor of basolateral HCO(3)(-)-dependent anion transporters)-sensitive components, which reflect anion uptake via basolateral cAMP-dependent anion transporters.	Capsaicin	4-13	cathelicidin antimicrobial peptide	Homo sapiens	336-340
21474433-5	2011	In contrast, capsaicin potentiated apical Cl(-) conductance, which reflects conductivity through the cystic fibrosis transmembrane conductance regulator, a cAMP-regulated Cl(-) channel.	Capsaicin	13-22	CF transmembrane conductance regulator	Homo sapiens	101-152
21474433-5	2011	In contrast, capsaicin potentiated apical Cl(-) conductance, which reflects conductivity through the cystic fibrosis transmembrane conductance regulator, a cAMP-regulated Cl(-) channel.	Capsaicin	13-22	cathelicidin antimicrobial peptide	Homo sapiens	156-160
21474433-9	2011	Collectively, capsaicinoids inhibit cAMP-mediated anion transport through down-regulation of basolateral anion uptake, paradoxically accompanied by up-regulation of apical cystic fibrosis transmembrane conductance regulator-mediated anion conductance.	Capsaicin	14-27	cathelicidin antimicrobial peptide	Homo sapiens	36-40
21474433-9	2011	Collectively, capsaicinoids inhibit cAMP-mediated anion transport through down-regulation of basolateral anion uptake, paradoxically accompanied by up-regulation of apical cystic fibrosis transmembrane conductance regulator-mediated anion conductance.	Capsaicin	14-27	CF transmembrane conductance regulator	Homo sapiens	172-223
21667066-2	2011	The aim of our study was to assess the effect of mammalian vanilloid receptor subtype 1 (TRPV1) agonist (capsaicin) and antagonist (capsazepine) on insect behavioral thermoregulation.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	59-87
21852280-6	2011	The mechanism of action of topical capsaicin has been ascribed to depletion of substance P.	Capsaicin	35-44	tachykinin precursor 1	Homo sapiens	79-90
21852280-7	2011	However, experimental and clinical studies show that depletion of substance P from nociceptors is only a correlate of capsaicin treatment and has little, if any, causative role in pain relief.	Capsaicin	118-127	tachykinin precursor 1	Homo sapiens	66-77
21852280-10	2011	Peripheral neuropathic hypersensitivity is mediated by diverse mechanisms, including altered expression of the capsaicin receptor TRPV1 or other key ion channels in affected or intact adjacent peripheral nociceptive nerve fibres, aberrant re-innervation, and collateral sprouting, all of which are defunctionalized by topical capsaicin.	Capsaicin	111-120	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-135
21530339-11	2011	A degeneration of epidermal nerve fibers has previously been demonstrated for patches containing the TRPV1-agonist capsaicin and our findings suggest that this effect might also be relevant for lidocaine patches.	Capsaicin	115-124	transient receptor potential cation channel subfamily V member 1	Homo sapiens	101-106
21300690-0	2011	Capsaicin may induce breast cancer cell death through apoptosis-inducing factor involving mitochondrial dysfunction.	Capsaicin	0-9	apoptosis inducing factor mitochondria associated 1	Homo sapiens	54-79
21300690-2	2011	Capsaicin was found to inhibit cancer cell growth in caspase-3-deficient human breast cancer cells.	Capsaicin	0-9	caspase 3	Homo sapiens	53-62
21300690-5	2011	Capsaicin significantly decreased mitochondria membrane potential, induced the cleavage of PARP-1, and decreased procaspase-7 expression in both cells.	Capsaicin	0-9	poly(ADP-ribose) polymerase 1	Homo sapiens	91-97
21300690-6	2011	Apoptosis-inducing factor (AIF) was distinctly released from mitochondria and translocated into the cytoplasm and nucleus in MCF-7 cells (52.9%), but not in BT-20 cells (2%) after treatment with 200 muM of capsaicin for 24 hours.	Capsaicin	206-215	apoptosis inducing factor mitochondria associated 1	Homo sapiens	0-25
21300690-6	2011	Apoptosis-inducing factor (AIF) was distinctly released from mitochondria and translocated into the cytoplasm and nucleus in MCF-7 cells (52.9%), but not in BT-20 cells (2%) after treatment with 200 muM of capsaicin for 24 hours.	Capsaicin	206-215	apoptosis inducing factor mitochondria associated 1	Homo sapiens	27-30
22230393-6	2011	On the contrary, capsaicin was found to produce only an up-regulation of BCL2, an anti-apoptotic gene and MMP9, whereas no significant changes were reported in genes involved in inflammatory and immune responses.	Capsaicin	17-26	BCL2 apoptosis regulator	Homo sapiens	73-77
22230393-6	2011	On the contrary, capsaicin was found to produce only an up-regulation of BCL2, an anti-apoptotic gene and MMP9, whereas no significant changes were reported in genes involved in inflammatory and immune responses.	Capsaicin	17-26	matrix metallopeptidase 9	Homo sapiens	106-110
21667066-2	2011	The aim of our study was to assess the effect of mammalian vanilloid receptor subtype 1 (TRPV1) agonist (capsaicin) and antagonist (capsazepine) on insect behavioral thermoregulation.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	89-94
21667066-6	2011	The observed opposite effect of TRPV1 agonist and antagonist on insect behavioral thermoregulation, which is similar to the effect of these substances on thermoregulation in mammals, indicates indirectly that capsaicin may act on receptors in insects that are functionally similar to TRPV1.	Capsaicin	209-218	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
21667066-6	2011	The observed opposite effect of TRPV1 agonist and antagonist on insect behavioral thermoregulation, which is similar to the effect of these substances on thermoregulation in mammals, indicates indirectly that capsaicin may act on receptors in insects that are functionally similar to TRPV1.	Capsaicin	209-218	transient receptor potential cation channel subfamily V member 1	Homo sapiens	284-289
21741970-0	2011	Characterization of capsaicin induced responses in mice vas deferens: evidence of CGRP uptake.	Capsaicin	20-29	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	82-86
21737202-2	2011	Trigeminal pain can be triggered by activation of the transient receptor potential V1 channel (TRPV1), expressed by a subset of nociceptive trigeminal ganglia (TG) neurons and gated by capsaicin, noxious heat, and other noxious stimuli.	Capsaicin	185-194	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	95-100
21737202-3	2011	As 5HT is released in the periphery during inflammation and evokes thermal hyperalgesia, and TRPV1 is essential for thermal hyperalgesia, we hypothesized that 5HT increases the activity of capsaicin-sensitive trigeminal neurons and that this increase can be attenuated by pharmacologically targeting peripheral 5HT receptors.	Capsaicin	189-198	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	93-98
21737202-7	2011	5HT pretreatment evoked a significant increase in calcium accumulation in capsaicin-sensitive trigeminal neurons and enhanced capsaicin-evoked CGRP release, but had no significant effect when given alone.	Capsaicin	126-135	calcitonin-related polypeptide alpha	Rattus norvegicus	143-147
21737202-8	2011	Sumatriptan, ketanserin, and granisetron treatment attenuated calcium accumulation and 5HT enhancement of capsaicin-evoked CGRP release.	Capsaicin	106-115	calcitonin-related polypeptide alpha	Rattus norvegicus	123-127
21741970-2	2011	Capsaicin can stimulate the release of CGRP from intracellular stores of these nerves, but this phenomenon has not been investigated in-depth in isolated preparations.	Capsaicin	0-9	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	39-43
21741970-8	2011	The addition of CGRP receptor antagonists caused a transient potentiation of the twitch response and this potentiation was blocked by pretreatment with capsaicin and enhanced by incubation with exogenous CGRP.	Capsaicin	152-161	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	16-20
21741970-9	2011	During the second consecutive cumulative concentration-response curve with capsaicin, the first phase of concentration-response curve disappeared and this was partially restored when the mouse vas deferens was preincubated with CGRP, suggesting the uptake of exogenous CGRP by nerves.	Capsaicin	75-84	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	228-232
21741970-9	2011	During the second consecutive cumulative concentration-response curve with capsaicin, the first phase of concentration-response curve disappeared and this was partially restored when the mouse vas deferens was preincubated with CGRP, suggesting the uptake of exogenous CGRP by nerves.	Capsaicin	75-84	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	269-273
21741970-10	2011	Besides showing capsaicin-induced CGRP releases this study shows that exogenous CGRP can be taken up in vas deferens and can be re-released.	Capsaicin	16-25	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	34-38
21741970-10	2011	Besides showing capsaicin-induced CGRP releases this study shows that exogenous CGRP can be taken up in vas deferens and can be re-released.	Capsaicin	16-25	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	80-84
21957263-3	2011	The TRPV1 agonist capsaicin robustly enhanced glutamate release onto DMV neurons by acting at preterminal receptors in slices from intact mice, but failed to do so in slices from diabetic mice.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-9
21712529-4	2011	TRPV1 is a capsaicin- and heat-gated nociceptive ion channel implicated in thermosensation and hyperalgesia under inflammation or injury.	Capsaicin	11-20	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
22039321-9	2011	These effects were restored by co-treatment with calcitonin gene related peptide (CGRP) and NO-ASA in capsaicin-denervated animals.	Capsaicin	102-111	calcitonin related polypeptide alpha	Homo sapiens	49-80
22039321-9	2011	These effects were restored by co-treatment with calcitonin gene related peptide (CGRP) and NO-ASA in capsaicin-denervated animals.	Capsaicin	102-111	calcitonin related polypeptide alpha	Homo sapiens	82-86
21671576-6	2011	The preliminary biological studies have allowed the identification of some of the key structural features directing the blockage of capsaicin-induced Ca(2+) influx through TRPV1 channels, particularly, the strong preference showed for highly lipophilic acyl groups and substituted guanidine moieties.	Capsaicin	132-141	transient receptor potential cation channel subfamily V member 1	Homo sapiens	172-177
21705674-7	2011	Capsaicin-induced responses were recorded following inhibition of endothelin A and B receptors (ET(A) /ET(B)).	Capsaicin	0-9	endothelin receptor type A	Mus musculus	66-94
21705674-7	2011	Capsaicin-induced responses were recorded following inhibition of endothelin A and B receptors (ET(A) /ET(B)).	Capsaicin	0-9	endothelin receptor type A	Mus musculus	96-101
21705674-7	2011	Capsaicin-induced responses were recorded following inhibition of endothelin A and B receptors (ET(A) /ET(B)).	Capsaicin	0-9	endothelin receptor type B	Mus musculus	103-108
21705674-8	2011	Inhibition of ET(A) receptors abolished the capsaicin-mediated increases in MAP.	Capsaicin	44-53	endothelin receptor type A	Mus musculus	14-19
21705674-10	2011	Cultured endothelial cell exposure to capsaicin increased endothelin production as shown by an endothelin ELISA assay, which was attenuated by inhibition of TRPV1 or endothelin-converting enzyme.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	157-162
21440618-9	2011	In functional studies to evaluate whether either GABAergic population is activated by noxious stimulation, hindpaw intradermal injection of capsaicin followed by c-fos quantification in dorsal horn revealed co-expression c-fos and GAD65-GFP (quantified as 20-30% of GFP +ve population).	Capsaicin	140-149	FBJ osteosarcoma oncogene	Mus musculus	221-226
21440618-9	2011	In functional studies to evaluate whether either GABAergic population is activated by noxious stimulation, hindpaw intradermal injection of capsaicin followed by c-fos quantification in dorsal horn revealed co-expression c-fos and GAD65-GFP (quantified as 20-30% of GFP +ve population).	Capsaicin	140-149	glutamic acid decarboxylase 2	Mus musculus	231-236
21440618-10	2011	Co-expression was also detected for GAD67-GFP +ve neurones and capsaicin-induced c-fos but at a much reduced level of 4-5%.	Capsaicin	63-72	FBJ osteosarcoma oncogene	Mus musculus	81-86
21666106-3	2011	Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin- and heat-gated nociceptive ion channel implicated in thermosensation and pathological pain under conditions of inflammation or injury.	Capsaicin	54-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
21666106-3	2011	Transient receptor potential vanilloid 1 (TRPV1) is a capsaicin- and heat-gated nociceptive ion channel implicated in thermosensation and pathological pain under conditions of inflammation or injury.	Capsaicin	54-63	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
21666106-5	2011	We demonstrate that cold strongly suppressed the activation of recombinant TRPV1 by multiple agonists and capsaicin-evoked currents in trigeminal ganglia neurons under normal and phosphorylated conditions.	Capsaicin	106-115	transient receptor potential cation channel subfamily V member 1	Homo sapiens	75-80
21939521-4	2011	METHODS: Cough reflex sensitivity to inhaled capsaicin was observed under NO depletion caused by NO synthase (NOS) inhibitors in non-sensitized and ovalbumin (OVA)-sensitized guinea pigs.	Capsaicin	45-54	nitric oxide synthase, inducible	Cavia porcellus	97-108
21917790-6	2011	Using preprotachykinin A knock-out mice, we first confirmed that substance P partly mediates intraplantar formalin- and capsaicin-induced pain behaviors.	Capsaicin	120-129	tachykinin 1	Mus musculus	65-76
21917790-9	2011	We found that both agonists were able to decrease formalin- and capsaicin-induced pain, an effect that was correlated with a reduction in the number of c-fos-positive neurons in the superficial laminae of the lumbar spinal cord.	Capsaicin	64-73	FBJ osteosarcoma oncogene	Mus musculus	152-157
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Capsaicin	142-151	tachykinin 1	Mus musculus	26-31
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Capsaicin	142-151	tachykinin 1	Mus musculus	33-45
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Capsaicin	142-151	opioid receptor, mu 1	Mus musculus	95-99
21917790-10	2011	Finally, visualization of NK(1) (neurokinin 1) receptor internalization revealed that DOPR and MOPR activation strongly reduced formalin- and capsaicin-induced substance P release via direct action on primary afferent fibers.	Capsaicin	142-151	tachykinin 1	Mus musculus	160-171
21777304-8	2011	Applied at a ratio of 1 : 1 (PRL:Delta1-9-G129R-hPRL; 40 nm each), this antagonist was able to nearly (  80%) reverse PRL-induced sensitization of capsaicin responses in rat sensory neurons.	Capsaicin	147-156	prolactin	Rattus norvegicus	29-32
21777304-8	2011	Applied at a ratio of 1 : 1 (PRL:Delta1-9-G129R-hPRL; 40 nm each), this antagonist was able to nearly (  80%) reverse PRL-induced sensitization of capsaicin responses in rat sensory neurons.	Capsaicin	147-156	prolactin	Homo sapiens	48-52
21777304-8	2011	Applied at a ratio of 1 : 1 (PRL:Delta1-9-G129R-hPRL; 40 nm each), this antagonist was able to nearly (  80%) reverse PRL-induced sensitization of capsaicin responses in rat sensory neurons.	Capsaicin	147-156	prolactin	Rattus norvegicus	49-52
21601581-0	2011	Inhibition of ERK phosphorylation by substance P N-terminal fragment decreases capsaicin-induced nociceptive response.	Capsaicin	79-88	mitogen-activated protein kinase 1	Mus musculus	14-17
21844219-7	2011	Furthermore, activation of TRPV1 by capsaicin led to a 54% reduction of KCNQ2/3-mediated current amplitude and attenuation of KCNQ2/3 activation.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
21844219-7	2011	Furthermore, activation of TRPV1 by capsaicin led to a 54% reduction of KCNQ2/3-mediated current amplitude and attenuation of KCNQ2/3 activation.	Capsaicin	36-45	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	72-77
21844219-7	2011	Furthermore, activation of TRPV1 by capsaicin led to a 54% reduction of KCNQ2/3-mediated current amplitude and attenuation of KCNQ2/3 activation.	Capsaicin	36-45	potassium voltage-gated channel subfamily Q member 2	Homo sapiens	126-131
21601581-11	2011	Taken together, these findings suggest that the activation of ERK, but not p38 and JNK MAPKs in the spinal cord, contributes to intraplantar capsaicin-induced nociception, and that blocking ERK activation via substance P (1-7) binding sites may provide significant antinociception at the spinal cord level.	Capsaicin	141-150	mitogen-activated protein kinase 1	Mus musculus	190-193
21601581-7	2011	In Western blot analysis, intraplantar injection of capsaicin (400 and 1600 ng/paw) produced an increase of ERK phosphorylation in the dorsal spinal cord, whereas expression of p38 and c-Jun N-terminal kinase (JNK) phosphorylation was unchanged by capsaicin treatment.	Capsaicin	52-61	mitogen-activated protein kinase 1	Mus musculus	108-111
21601581-7	2011	In Western blot analysis, intraplantar injection of capsaicin (400 and 1600 ng/paw) produced an increase of ERK phosphorylation in the dorsal spinal cord, whereas expression of p38 and c-Jun N-terminal kinase (JNK) phosphorylation was unchanged by capsaicin treatment.	Capsaicin	52-61	mitogen-activated protein kinase 14	Mus musculus	177-180
21601581-7	2011	In Western blot analysis, intraplantar injection of capsaicin (400 and 1600 ng/paw) produced an increase of ERK phosphorylation in the dorsal spinal cord, whereas expression of p38 and c-Jun N-terminal kinase (JNK) phosphorylation was unchanged by capsaicin treatment.	Capsaicin	52-61	mitogen-activated protein kinase 8	Mus musculus	185-208
21601581-7	2011	In Western blot analysis, intraplantar injection of capsaicin (400 and 1600 ng/paw) produced an increase of ERK phosphorylation in the dorsal spinal cord, whereas expression of p38 and c-Jun N-terminal kinase (JNK) phosphorylation was unchanged by capsaicin treatment.	Capsaicin	52-61	mitogen-activated protein kinase 8	Mus musculus	210-213
21601581-7	2011	In Western blot analysis, intraplantar injection of capsaicin (400 and 1600 ng/paw) produced an increase of ERK phosphorylation in the dorsal spinal cord, whereas expression of p38 and c-Jun N-terminal kinase (JNK) phosphorylation was unchanged by capsaicin treatment.	Capsaicin	248-257	mitogen-activated protein kinase 8	Mus musculus	210-213
21601581-9	2011	substance P (1-7) inhibited capsaicin-induced ERK phosphorylation, which was reversed by [D-Pro(2), D-Phe(7)]substance P (1-7), a substance P (1-7) antagonist.	Capsaicin	28-37	mitogen-activated protein kinase 1	Mus musculus	46-49
21601581-10	2011	Both nociceptive behavioral response and spinal ERK activation induced by intraplantar capsaicin were reduced by U0126, an upstream inhibitor of ERK phosphorylation.	Capsaicin	87-96	mitogen-activated protein kinase 1	Mus musculus	48-51
21601581-10	2011	Both nociceptive behavioral response and spinal ERK activation induced by intraplantar capsaicin were reduced by U0126, an upstream inhibitor of ERK phosphorylation.	Capsaicin	87-96	mitogen-activated protein kinase 1	Mus musculus	145-148
21601581-11	2011	Taken together, these findings suggest that the activation of ERK, but not p38 and JNK MAPKs in the spinal cord, contributes to intraplantar capsaicin-induced nociception, and that blocking ERK activation via substance P (1-7) binding sites may provide significant antinociception at the spinal cord level.	Capsaicin	141-150	mitogen-activated protein kinase 1	Mus musculus	62-65
21861907-4	2011	LA-induced activation and sensitization of TRPV1 involves a domain that is similar, but not identical to the vanilloid-binding domain.	Capsaicin	109-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	43-48
21543639-8	2011	Perivagal capsaicin, which is supposed to induce a selective degeneration of C-fibers, decreased the number of cNTS neurons responding to capsaicin or CCK-8s but not those responding to alpha,beta-Met-ATP.	Capsaicin	10-19	cholecystokinin	Homo sapiens	151-154
21621010-6	2011	Heat and capsaicin-evoked responses were both blocked by TRPV1 antagonist, capsazepine.	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	57-62
21636531-2	2011	Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive, Ca(2+)-selective ion channel activated by capsaicin, heat, and protons.	Capsaicin	109-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-40
21636531-2	2011	Transient receptor potential vanilloid 1 (TRPV1) is a nociceptive, Ca(2+)-selective ion channel activated by capsaicin, heat, and protons.	Capsaicin	109-118	transient receptor potential cation channel subfamily V member 1	Homo sapiens	42-47
21636531-5	2011	Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA.	Capsaicin	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	0-13
21636531-5	2011	Interleukin-8 (IL-8) secreted by Het1A cells upon stimulation by capsaicin or acid with/without 4-hydroxy-2-nonenal (HNE) was measured by ELISA.	Capsaicin	65-74	C-X-C motif chemokine ligand 8	Homo sapiens	15-19
21636531-8	2011	Capsaicin and acid induced IL-8 production in Het1A cells, and this production was diminished by antagonists of TRPV1.	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	27-31
21636531-8	2011	Capsaicin and acid induced IL-8 production in Het1A cells, and this production was diminished by antagonists of TRPV1.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	112-117
21636531-10	2011	Moreover, IL-8 production in capsaicin-stimulated Het1A cells was enhanced by synthetic HNE treatment.	Capsaicin	29-38	C-X-C motif chemokine ligand 8	Homo sapiens	10-14
21543639-3	2011	Since it has been suggested that cholecystokinin (CCK), exerts its gastrointestinal (GI)-related effects via paracrine activation of vagal afferent C-fibers, we tested whether CCK-sensitive fibers impinging upon cNTS neurons are responsive to vanilloid but not purinergic agonists.	Capsaicin	243-252	cholecystokinin	Homo sapiens	33-48
21543639-10	2011	Our data also indicate that CCK-8s increases glutamate release from purinergic and vanilloid responsive fibers impinging on cNTS neurons.	Capsaicin	83-92	cholecystokinin	Homo sapiens	28-31
21543639-7	2011	All neurons responding to either alpha,beta-Met-ATP or CCK-8s were also responsive to capsaicin.	Capsaicin	86-95	cholecystokinin	Homo sapiens	55-58
21069423-3	2011	Ear oedema induced by topical application of TRPV1 agonist capsaicin was completely absent in TRPV1 knockdown mice.	Capsaicin	59-68	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	45-50
21794120-7	2011	Capsaicin-stimulated release of calcitonin gene related peptide (CGRP) was significantly higher in the spinal cord of STZ-treated animals.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	32-63
21575625-6	2011	JNJ-39729209 displaced tritiated resiniferotoxin binding to TRPV1 and prevented TRPV1 activation by capsaicin, protons and heat.	Capsaicin	100-109	transient receptor potential cation channel subfamily V member 1	Homo sapiens	80-85
21763901-6	2011	Capsaicin-evoked neurosecretion of CGRP and tissue content were measured using a previously validated radioimmunoassay.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	35-39
21763901-7	2011	RESULTS: Dental pulp from female rats at 7 days showed significantly increased capsaicin-evoked immunoreactive CGRP release (&gt;50% increase) compared with tissue from male rats.	Capsaicin	79-88	calcitonin-related polypeptide alpha	Rattus norvegicus	111-115
21493704-2	2011	METHODS AND RESULTS: In ECs, TRPV1 ligands (evodiamine or capsaicin) promoted NO production, eNOS phosphorylation, and the formation of a TRPV1-eNOS complex, which were all abrogated by the TRPV1 antagonist capsazepine.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
21493704-2	2011	METHODS AND RESULTS: In ECs, TRPV1 ligands (evodiamine or capsaicin) promoted NO production, eNOS phosphorylation, and the formation of a TRPV1-eNOS complex, which were all abrogated by the TRPV1 antagonist capsazepine.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	138-143
21493704-2	2011	METHODS AND RESULTS: In ECs, TRPV1 ligands (evodiamine or capsaicin) promoted NO production, eNOS phosphorylation, and the formation of a TRPV1-eNOS complex, which were all abrogated by the TRPV1 antagonist capsazepine.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	138-143
21595740-2	2011	The present study investigated whether the somatostatin receptor (SSTR) agonist, octreotide, could inhibit the activation of dorsal skin afferent fibres induced by local injection of capsaicin in the rat.	Capsaicin	183-192	somatostatin receptor 3	Rattus norvegicus	43-64
21595740-2	2011	The present study investigated whether the somatostatin receptor (SSTR) agonist, octreotide, could inhibit the activation of dorsal skin afferent fibres induced by local injection of capsaicin in the rat.	Capsaicin	183-192	somatostatin receptor 3	Rattus norvegicus	66-70
21595740-10	2011	The present study provides electrophysiological evidence that the signal evoked by the somatostatin receptor inhibits the activation and mechanical sensitization evoked by capsaicin in the terminals in small-diameter sensory neurons.	Capsaicin	172-181	somatostatin receptor 3	Rattus norvegicus	87-108
21626018-0	2011	Triptans attenuate capsaicin-induced CREB phosphorylation within the trigeminal nucleus caudalis: a mechanism to prevent central sensitization?	Capsaicin	19-28	cAMP responsive element binding protein 1	Rattus norvegicus	37-41
21794120-7	2011	Capsaicin-stimulated release of calcitonin gene related peptide (CGRP) was significantly higher in the spinal cord of STZ-treated animals.	Capsaicin	0-9	calcitonin-related polypeptide alpha	Rattus norvegicus	65-69
21550252-6	2011	The CHEP after application of capsaicin show features observed in some patients with painful neuropathy, and could provide a model for development of novel analgesics, particularly TRPV1 antagonists.	Capsaicin	30-39	transient receptor potential cation channel subfamily V member 1	Homo sapiens	181-186
21109472-3	2011	In the present work, we have studied the central effects of SSTR2 activation on capsaicin (CAP)-induced glutamate release in mouse DH.	Capsaicin	80-89	somatostatin receptor 2	Mus musculus	60-65
21109472-3	2011	In the present work, we have studied the central effects of SSTR2 activation on capsaicin (CAP)-induced glutamate release in mouse DH.	Capsaicin	91-94	somatostatin receptor 2	Mus musculus	60-65
21109472-4	2011	In neurons of the lamina II of DH, CAP (2 muM) induced a strong increase of mEPSC frequency that was significantly reduced (70%) by OCT. SSTR2 involvement was assessed by using the specific antagonist CYN 154806.	Capsaicin	35-38	somatostatin receptor 2	Mus musculus	137-142
21767384-4	2011	In both NC and IM groups, the TRPV1 agonists capsaicin (CP) and olvanil (OL) administered intraperitoneally provided significant antidepressant-like attenuation against these behavioral alterations, whereas the TRPV1 antagonist capsazepine (CZ) did not attenuate any depression-like behaviors.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	30-35
21525372-0	2011	Reduced expression of SynGAP, a neuronal GTPase-activating protein, enhances capsaicin-induced peripheral sensitization.	Capsaicin	77-86	synaptic Ras GTPase activating protein 1 homolog (rat)	Mus musculus	22-28
21708955-14	2011	Repeated excitation and capsaicin also restored contractility, possibly because of the release of endogenous CGRP from nerve endings in the isolated muscles.	Capsaicin	24-33	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	109-113
21525372-5	2011	Our results demonstrate that SynGAP is expressed in primary afferent sensory neurons and that the capsaicin-stimulated CGRP release from spinal cord slices was two-fold higher from SynGAP(+/-) mice than that observed from WT mouse tissue, consistent with an increase in expression of the capsaicin receptor, transient receptor potential cation channel subfamily V member 1 (TRPV1), in SynGAP(+/-) dorsal root ganglia.	Capsaicin	98-107	synaptic Ras GTPase activating protein 1 homolog (rat)	Mus musculus	29-35
21525372-5	2011	Our results demonstrate that SynGAP is expressed in primary afferent sensory neurons and that the capsaicin-stimulated CGRP release from spinal cord slices was two-fold higher from SynGAP(+/-) mice than that observed from WT mouse tissue, consistent with an increase in expression of the capsaicin receptor, transient receptor potential cation channel subfamily V member 1 (TRPV1), in SynGAP(+/-) dorsal root ganglia.	Capsaicin	98-107	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	119-123
21525372-5	2011	Our results demonstrate that SynGAP is expressed in primary afferent sensory neurons and that the capsaicin-stimulated CGRP release from spinal cord slices was two-fold higher from SynGAP(+/-) mice than that observed from WT mouse tissue, consistent with an increase in expression of the capsaicin receptor, transient receptor potential cation channel subfamily V member 1 (TRPV1), in SynGAP(+/-) dorsal root ganglia.	Capsaicin	98-107	synaptic Ras GTPase activating protein 1 homolog (rat)	Mus musculus	181-187
21525372-5	2011	Our results demonstrate that SynGAP is expressed in primary afferent sensory neurons and that the capsaicin-stimulated CGRP release from spinal cord slices was two-fold higher from SynGAP(+/-) mice than that observed from WT mouse tissue, consistent with an increase in expression of the capsaicin receptor, transient receptor potential cation channel subfamily V member 1 (TRPV1), in SynGAP(+/-) dorsal root ganglia.	Capsaicin	98-107	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	374-379
21525372-5	2011	Our results demonstrate that SynGAP is expressed in primary afferent sensory neurons and that the capsaicin-stimulated CGRP release from spinal cord slices was two-fold higher from SynGAP(+/-) mice than that observed from WT mouse tissue, consistent with an increase in expression of the capsaicin receptor, transient receptor potential cation channel subfamily V member 1 (TRPV1), in SynGAP(+/-) dorsal root ganglia.	Capsaicin	98-107	synaptic Ras GTPase activating protein 1 homolog (rat)	Mus musculus	181-187
21525372-7	2011	In contrast, capsaicin-induced thermal hypernociception occurred at lower doses of capsaicin and had a longer duration in SynGAP(+/-) mice than WT mice.	Capsaicin	13-22	synaptic Ras GTPase activating protein 1 homolog (rat)	Mus musculus	122-128
21525372-8	2011	These results provide the first evidence that SynGAP is an important regulator of neuropeptide release from primary sensory neurons and can modulate capsaicin-induced hypernociception, demonstrating the importance of GAP regulation in signaling pathways that play a role in peripheral sensitization.	Capsaicin	149-158	synaptic Ras GTPase activating protein 1 homolog (rat)	Mus musculus	46-52
21672568-0	2011	Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception.	Capsaicin	104-113	prepronociceptin	Homo sapiens	49-59
21576274-8	2011	Inhibition of sensory neurotransmitter release (capsaicin; 10 muM) significantly increased the amplitude of nerve-mediated contraction (P &lt;0.05), with a greater effect in control than obese animals, although the density of sensory nerves was unaffected by obesity.	Capsaicin	48-57	latexin	Homo sapiens	62-65
21672568-0	2011	Antinociceptive effects of spinally administered nociceptin/orphanin FQ and its N-terminal fragments on capsaicin-induced nociception.	Capsaicin	104-113	prepronociceptin	Homo sapiens	60-71
21605612-1	2011	The presence of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in capsaicin-sensitive peptidergic sensory nerves, inflammatory and immune cells suggest its involvement in inflammation.	Capsaicin	96-105	adenylate cyclase activating polypeptide 1	Mus musculus	16-66
21605612-1	2011	The presence of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors in capsaicin-sensitive peptidergic sensory nerves, inflammatory and immune cells suggest its involvement in inflammation.	Capsaicin	96-105	adenylate cyclase activating polypeptide 1	Mus musculus	68-73
21672568-3	2011	N/OFQ (1-13), (1-11) and (1-7) have antinociceptive activity in the pain-related behavior after intraplantar injection of capsaicin.	Capsaicin	122-131	prepronociceptin	Homo sapiens	0-5
21672568-5	2011	administration of N/OFQ (0.3-1.2 nmol) produced an appreciable and dose-dependent inhibition of capsaicin-induced paw-licking/biting response.	Capsaicin	96-105	prepronociceptin	Homo sapiens	18-23
21623392-2	2011	TRPV1 channel is expressed in the beta cells and capsaicin induces insulin secretion similarly to glucose.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
21466812-9	2011	Interestingly, repeated treatment with the TRPV1 agonist, capsaicin, abrogated it edematogenic response, confirming the desensitization process and partially decreasing the cinnamaldehyde-induced edema, suggesting the involvement of capsaicin-sensitive fibers.	Capsaicin	58-67	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
21466812-9	2011	Interestingly, repeated treatment with the TRPV1 agonist, capsaicin, abrogated it edematogenic response, confirming the desensitization process and partially decreasing the cinnamaldehyde-induced edema, suggesting the involvement of capsaicin-sensitive fibers.	Capsaicin	233-242	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	43-48
21653872-5	2011	Following PIP(2) degradation, increased TRPV1:AKAP150 coimmunoprecipitation was observed, resulting in increased receptor response to capsaicin treatment.	Capsaicin	134-143	prolactin induced protein	Mus musculus	10-13
21653872-5	2011	Following PIP(2) degradation, increased TRPV1:AKAP150 coimmunoprecipitation was observed, resulting in increased receptor response to capsaicin treatment.	Capsaicin	134-143	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	40-45
21653872-5	2011	Following PIP(2) degradation, increased TRPV1:AKAP150 coimmunoprecipitation was observed, resulting in increased receptor response to capsaicin treatment.	Capsaicin	134-143	A kinase (PRKA) anchor protein 5	Mus musculus	46-53
21642979-3	2011	A peptide of CRMP-2 fused to the HIV transactivator of transcription (TAT) protein (TAT-CBD3) decreased neuropeptide release from sensory neurons and excitatory synaptic transmission in dorsal horn neurons, reduced meningeal blood flow, reduced nocifensive behavior induced by formalin injection or corneal capsaicin application and reversed neuropathic hypersensitivity produced by an antiretroviral drug.	Capsaicin	307-316	dihydropyrimidinase like 2	Homo sapiens	13-19
21639869-11	2011	Intrathecal administration of the mast cell stabilizer sodium cromoglycate or the spleen tyrosine kinase (Syk) inhibitor BAY-613606 reduce the increased percent degranulation and degranulated cell density of lumbar dural mast cells after capsaicin and carrageenan respectively, without affecting hyperalgesia.	Capsaicin	238-247	spleen associated tyrosine kinase	Rattus norvegicus	106-109
21474332-4	2011	We analyzed the role of capsaicin in the tumor necrosis factor (TNF)-alpha secretion by PC-3 cells which was increased at shorter times than IL-6 production.	Capsaicin	24-33	tumor necrosis factor	Homo sapiens	41-74
21502857-12	2011	At subactivating concentrations (less than 1 mM), QX-314 potently inhibited capsaicin-evoked TRPV1 currents with an IC50 of 8.0 +- 0.6 muM.	Capsaicin	76-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	93-98
21502857-12	2011	At subactivating concentrations (less than 1 mM), QX-314 potently inhibited capsaicin-evoked TRPV1 currents with an IC50 of 8.0 +- 0.6 muM.	Capsaicin	76-85	latexin	Homo sapiens	135-138
21502857-13	2011	CONCLUSIONS: The results of this study show that the quaternary lidocaine derivative QX-314 exerts biphasic effects on TRPV1 channels, inhibiting capsaicin-evoked TRPV1 currents at lower (micromolar) concentrations and activating TRPV1 channels at higher (millimolar) concentrations.	Capsaicin	146-155	transient receptor potential cation channel subfamily V member 1	Homo sapiens	119-124
21502857-13	2011	CONCLUSIONS: The results of this study show that the quaternary lidocaine derivative QX-314 exerts biphasic effects on TRPV1 channels, inhibiting capsaicin-evoked TRPV1 currents at lower (micromolar) concentrations and activating TRPV1 channels at higher (millimolar) concentrations.	Capsaicin	146-155	transient receptor potential cation channel subfamily V member 1	Homo sapiens	163-168
21502857-13	2011	CONCLUSIONS: The results of this study show that the quaternary lidocaine derivative QX-314 exerts biphasic effects on TRPV1 channels, inhibiting capsaicin-evoked TRPV1 currents at lower (micromolar) concentrations and activating TRPV1 channels at higher (millimolar) concentrations.	Capsaicin	146-155	transient receptor potential cation channel subfamily V member 1	Homo sapiens	163-168
21474332-0	2011	The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.	Capsaicin	4-13	interleukin 6	Homo sapiens	32-36
21474332-5	2011	Furthermore, incubation of PC-3 cells with an anti-TNF-alpha antibody blocked the capsaicin-induced IL-6 secretion.	Capsaicin	82-91	tumor necrosis factor	Homo sapiens	51-60
21474332-0	2011	The vanilloid capsaicin induces IL-6 secretion in prostate PC-3 cancer cells.	Capsaicin	14-23	interleukin 6	Homo sapiens	32-36
21474332-5	2011	Furthermore, incubation of PC-3 cells with an anti-TNF-alpha antibody blocked the capsaicin-induced IL-6 secretion.	Capsaicin	82-91	interleukin 6	Homo sapiens	100-104
21474332-3	2011	Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK).	Capsaicin	0-9	interleukin 6	Homo sapiens	70-74
21474332-6	2011	These results raise the possibility that capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activation.	Capsaicin	41-50	interleukin 6	Homo sapiens	60-64
21474332-3	2011	Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	161-166
21474332-3	2011	Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK).	Capsaicin	0-9	protein kinase C alpha	Homo sapiens	220-229
21474332-6	2011	These results raise the possibility that capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activation.	Capsaicin	41-50	tumor necrosis factor	Homo sapiens	137-146
21474332-3	2011	Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK).	Capsaicin	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	231-265
21474332-3	2011	Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK).	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	275-278
21474332-3	2011	Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK).	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	283-328
21474332-3	2011	Capsaicin-treated PC-3 cells increased the synthesis and secretion of IL-6 which was abrogated by the transient receptor potential vanilloid receptor subtype 1 (TRPV1) antagonist capsazepine, as well as by inhibitors of PKC-alpha, phosphoinositol-3 phosphate kinase (PI-3K), Akt and extracellular signal-regulated protein kinase (ERK).	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	330-333
21474332-6	2011	These results raise the possibility that capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activation.	Capsaicin	41-50	AKT serine/threonine kinase 1	Homo sapiens	189-192
21474332-6	2011	These results raise the possibility that capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activation.	Capsaicin	41-50	mitogen-activated protein kinase 1	Homo sapiens	194-197
21474332-6	2011	These results raise the possibility that capsaicin-mediated IL-6 increase in prostate cancer PC-3 cells is regulated at least in part by TNF-alpha secretion and signaling pathway involving Akt, ERK and PKC-alpha activation.	Capsaicin	41-50	protein kinase C alpha	Homo sapiens	202-211
21393555-5	2011	Third, LPS significantly sensitized TRPV1 to capsaicin measured by (Ca(2+))(i), release of calcitonin gene-related peptide, and inward currents.	Capsaicin	45-54	transient receptor potential cation channel subfamily V member 1	Homo sapiens	36-41
21745629-0	2011	Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.	Capsaicin	0-9	MAPK associated protein 1	Homo sapiens	53-86
21514666-4	2011	Isolated rat and mouse skin preparations were used to measure CGRP release induced by noxious heat (47 C) and capsaicin (0.5muM), stimuli known to activate the capsaicin receptor TRPV1.	Capsaicin	110-119	calcitonin/calcitonin-related polypeptide, alpha	Mus musculus	62-66
21514666-4	2011	Isolated rat and mouse skin preparations were used to measure CGRP release induced by noxious heat (47 C) and capsaicin (0.5muM), stimuli known to activate the capsaicin receptor TRPV1.	Capsaicin	110-119	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	179-184
21337373-6	2011	However, low concentrations of CAP (20 nM) produced a higher response after PIP(2) depletion in cells containing TRPV1 alone but not TRPV1 together with TRPA1.	Capsaicin	31-34	prolactin-inducible protein	Cricetulus griseus	76-79
21337373-6	2011	However, low concentrations of CAP (20 nM) produced a higher response after PIP(2) depletion in cells containing TRPV1 alone but not TRPV1 together with TRPA1.	Capsaicin	31-34	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	113-118
21337373-6	2011	However, low concentrations of CAP (20 nM) produced a higher response after PIP(2) depletion in cells containing TRPV1 alone but not TRPV1 together with TRPA1.	Capsaicin	31-34	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily A member 1	Cricetulus griseus	153-158
21523557-0	2011	Capsaicin-induced vasodilatation in human nasal vasculature is mediated by modulation of cyclooxygenase-2 activity and abrogated by sulprostone.	Capsaicin	0-9	prostaglandin-endoperoxide synthase 2	Homo sapiens	89-105
21523557-1	2011	Extensively based on evidence gained from experimental animal models, the transient receptor potential vanilloid receptor type 1 (TRPV1)-activator capsaicin is regarded as a valuable tool in the research on neurogenic inflammation.	Capsaicin	147-156	transient receptor potential cation channel subfamily V member 1	Homo sapiens	130-135
21745629-9	2011	Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity.	Capsaicin	94-103	MAPK associated protein 1	Homo sapiens	59-64
21745629-9	2011	Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity.	Capsaicin	94-103	C-X-C motif chemokine ligand 8	Homo sapiens	69-73
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Capsaicin	79-88	MAPK associated protein 1	Homo sapiens	186-219
21745629-0	2011	Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.	Capsaicin	0-9	C-X-C motif chemokine ligand 8	Homo sapiens	91-104
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Capsaicin	79-88	MAPK associated protein 1	Homo sapiens	221-226
21745629-9	2011	Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity.	Capsaicin	94-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	145-150
21745629-9	2011	Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity.	Capsaicin	94-103	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	170-175
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Capsaicin	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	232-245
21745629-0	2011	Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.	Capsaicin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	152-157
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Capsaicin	79-88	C-X-C motif chemokine ligand 8	Homo sapiens	247-251
21745629-2	2011	In this study, we tested the hypothesis that the anti-inflammatory activity of capsaicin can be used to improve free fatty acid (FFA)-induced inflammation by reducing gene expression of macrophage inflammatory protein 1 (MIP-1) and interleukin 8 (IL-8) in THP-1 (human acute monocytic leukemia cell) macrophages.	Capsaicin	79-88	GLI family zinc finger 2	Homo sapiens	256-261
21745629-3	2011	To investigate whether capsaicin ameliorates palmitate-induced MIP-1 and IL-8 gene expressions, we treated THP-1 cells with palmitate in the presence or absence of capsaicin and measured MIP-1 and IL-8 by real-time polymerase chain reaction.	Capsaicin	23-32	MAPK associated protein 1	Homo sapiens	63-68
21745629-3	2011	To investigate whether capsaicin ameliorates palmitate-induced MIP-1 and IL-8 gene expressions, we treated THP-1 cells with palmitate in the presence or absence of capsaicin and measured MIP-1 and IL-8 by real-time polymerase chain reaction.	Capsaicin	23-32	C-X-C motif chemokine ligand 8	Homo sapiens	73-77
21745629-4	2011	To elucidate the mechanism by which capsaicin effects on palmitate-induced MIP-1 and IL-8 gene expressions, we performed immunoblotting with stress kinase-related antibodies and measured palmitate oxidation and palmitate oxidation-related gene expression.	Capsaicin	36-45	MAPK associated protein 1	Homo sapiens	75-80
21745629-9	2011	Our data suggest that the attenuation of palmitate-induced MIP-1 and IL-8 gene expressions by capsaicin is associated with reduced activation of c-Jun N-terminal kinase, c-Jun, and p38 and preserved beta-oxidation activity.	Capsaicin	94-103	mitogen-activated protein kinase 14	Homo sapiens	181-184
21745629-0	2011	Capsaicin attenuates palmitate-induced expression of macrophage inflammatory protein 1 and interleukin 8 by increasing palmitate oxidation and reducing c-Jun activation in THP-1 (human acute monocytic leukemia cell) cells.	Capsaicin	0-9	GLI family zinc finger 2	Homo sapiens	172-177
21745629-4	2011	To elucidate the mechanism by which capsaicin effects on palmitate-induced MIP-1 and IL-8 gene expressions, we performed immunoblotting with stress kinase-related antibodies and measured palmitate oxidation and palmitate oxidation-related gene expression.	Capsaicin	36-45	C-X-C motif chemokine ligand 8	Homo sapiens	85-89
21745629-6	2011	Treatment with capsaicin or FFA oxidation stimulators inhibited palmitate-induced MIP-1 and IL-8 expressions in THP-1 macrophages.	Capsaicin	15-24	MAPK associated protein 1	Homo sapiens	82-87
21215321-3	2011	Inhalation of capsaicin aerosol, a selective agonist of TRPV1, consistently and reproducibly evoked coughs in a dose-dependent manner in both healthy humans and in patients with airway inflammatory diseases.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	56-61
21745629-6	2011	Treatment with capsaicin or FFA oxidation stimulators inhibited palmitate-induced MIP-1 and IL-8 expressions in THP-1 macrophages.	Capsaicin	15-24	C-X-C motif chemokine ligand 8	Homo sapiens	92-96
21745629-6	2011	Treatment with capsaicin or FFA oxidation stimulators inhibited palmitate-induced MIP-1 and IL-8 expressions in THP-1 macrophages.	Capsaicin	15-24	GLI family zinc finger 2	Homo sapiens	112-117
21745629-8	2011	Furthermore, capsaicin significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase, c-Jun, and p38.	Capsaicin	13-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	80-85
21745629-8	2011	Furthermore, capsaicin significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase, c-Jun, and p38.	Capsaicin	13-22	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	105-110
21745629-8	2011	Furthermore, capsaicin significantly reduced palmitate-stimulated activation of c-Jun N-terminal kinase, c-Jun, and p38.	Capsaicin	13-22	mitogen-activated protein kinase 14	Homo sapiens	116-119
21626599-6	2011	These results suggest that capsaicin exerts its lipolytic action by increasing the hydrolysis of triacylglycerol in adipocytes, and that these effects are mediated at least partially by regulation of the expression of multiple genes that are involved in the lipid catabolic pathway, such as HSL and CPT-Ialpha, and those involved in thermogenesis such as UCP2.	Capsaicin	27-36	lipase E, hormone sensitive type	Homo sapiens	291-294
21626599-6	2011	These results suggest that capsaicin exerts its lipolytic action by increasing the hydrolysis of triacylglycerol in adipocytes, and that these effects are mediated at least partially by regulation of the expression of multiple genes that are involved in the lipid catabolic pathway, such as HSL and CPT-Ialpha, and those involved in thermogenesis such as UCP2.	Capsaicin	27-36	uncoupling protein 2	Homo sapiens	355-359
21536874-0	2011	Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog.	Capsaicin	61-70	transient receptor potential cation channel subfamily V member 1	Homo sapiens	32-37
21459397-5	2011	Phosphorylated p38 immunoreactivity was increased in the cytoplasma of DRG cells at 2 h after the mustard oil treatment of the hind paw and 30 min after the perineural capsaicin application to the sciatic nerve axons, but not following heat or cold stimuli to the hind paws.	Capsaicin	168-177	mitogen activated protein kinase 14	Rattus norvegicus	15-18
21459397-8	2011	The present results show that sensory neurons respond with a selective long-lasting increase in p-ERK1/2 in small and medium-size DRG cells, when their axons or axon terminals are stimulated by capsaicin, mustard oil, noxious heat or noxious cold.	Capsaicin	194-203	mitogen activated protein kinase 3	Rattus norvegicus	98-104
21536874-5	2011	We synthesized a series of permanently charged capsaicinoids and found that one, cap-ET, efficaciously evoked TRPV1-dependent entry of Ca(2+) or the large cationic dye YO-PRO-1 comparably to capsaicin, but far smaller electrical currents.	Capsaicin	47-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
21536874-5	2011	We synthesized a series of permanently charged capsaicinoids and found that one, cap-ET, efficaciously evoked TRPV1-dependent entry of Ca(2+) or the large cationic dye YO-PRO-1 comparably to capsaicin, but far smaller electrical currents.	Capsaicin	47-60	lamin A/C	Homo sapiens	171-176
21536874-5	2011	We synthesized a series of permanently charged capsaicinoids and found that one, cap-ET, efficaciously evoked TRPV1-dependent entry of Ca(2+) or the large cationic dye YO-PRO-1 comparably to capsaicin, but far smaller electrical currents.	Capsaicin	47-56	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
21536874-5	2011	We synthesized a series of permanently charged capsaicinoids and found that one, cap-ET, efficaciously evoked TRPV1-dependent entry of Ca(2+) or the large cationic dye YO-PRO-1 comparably to capsaicin, but far smaller electrical currents.	Capsaicin	47-56	lamin A/C	Homo sapiens	171-176
21232043-1	2011	BACKGROUND AND PURPOSE: Capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1) channels, is pro-nociceptive in the periphery but is anti-nociceptive when administered into the ventrolateral periaqueductal gray (vlPAG), a midbrain region for initiating descending pain inhibition.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	49-89
21562271-5	2011	The selective TRPV4 agonists 4alpha-PDD and GSK1016790A elevated [Ca2+]i in dissociated RGCs in a dose-dependent manner, whereas the TRPV1 agonist capsaicin had no effect on [Ca2+](RGC).	Capsaicin	147-156	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	133-138
21232043-8	2011	Effects of capsaicin were antagonized by SB 366791, a TRPV1 channel antagonist.	Capsaicin	11-20	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	54-59
21232043-1	2011	BACKGROUND AND PURPOSE: Capsaicin, an agonist of transient receptor potential vanilloid 1 (TRPV1) channels, is pro-nociceptive in the periphery but is anti-nociceptive when administered into the ventrolateral periaqueductal gray (vlPAG), a midbrain region for initiating descending pain inhibition.	Capsaicin	24-33	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	91-96
21232043-5	2011	Capsaicin-induced eIPSC depression was antagonized by cannabinoid CB1 and metabotropic glutamate (mGlu5) receptor antagonists, and prevented by inhibiting diacylglycerol lipase (DAGL), which converts DAG into 2-arachidonoylglycerol (2-AG), an endocannabinoid.	Capsaicin	0-9	cannabinoid receptor 1	Rattus norvegicus	66-69
21232043-7	2011	Intra-vlPAG capsaicin reduced hot-plate responses in rats, effects blocked by CB1 and mGlu receptor antagonists.	Capsaicin	12-21	cannabinoid receptor 1	Rattus norvegicus	78-81
21232043-9	2011	CONCLUSIONS AND IMPLICATIONS: Capsaicin activated TRPV1s on glutamatergic terminals to release glutamate which activated postsynaptic mGlu5 receptors, yielding 2-AG from DAG by DAGL hydrolysis.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	50-55
21232043-12	2011	This is a novel TRPV1 channel-mediated anti-nociceptive mechanism in the brain and a new interaction between vanilloid and endocannabinoid systems.	Capsaicin	109-118	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	16-21
21654202-5	2011	This review summarizes the current knowledge of the molecular determinants of TRPV1 channel activation by heat, protons and capsaicin.	Capsaicin	124-133	transient receptor potential cation channel subfamily V member 1	Homo sapiens	78-83
21333704-7	2011	In addition, capsaicin significantly lowered the KA-induced increase in the concentration of the cytokines IL-1beta and TNF-alpha in the brain.	Capsaicin	13-22	interleukin 1 beta	Mus musculus	107-115
21310942-0	2011	Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
21310942-1	2011	Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	132-177
21310942-1	2011	Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	179-184
21310942-1	2011	Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1).	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	132-177
21310942-1	2011	Capsaicin (CPS) has been found to exhibit either tumor promoting or suppressing effects, many of which are mediated by the specific transient receptor potential vanilloid type-1 (TRPV1).	Capsaicin	11-14	transient receptor potential cation channel subfamily V member 1	Homo sapiens	179-184
21310942-2	2011	Herein, we provide evidence that CPS treatment induced a more aggressive gene phenotype and invasiveness in 5637 cells-lacking TRPV1 receptor.	Capsaicin	33-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	127-132
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	angiopoietin 1	Homo sapiens	70-84
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	angiopoietin 2	Homo sapiens	86-100
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	vascular endothelial growth factor A	Homo sapiens	105-139
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	matrix metallopeptidase 1	Homo sapiens	181-185
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	matrix metallopeptidase 9	Homo sapiens	187-191
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	TIMP metallopeptidase inhibitor 1	Homo sapiens	193-198
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	TIMP metallopeptidase inhibitor 3	Homo sapiens	200-205
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	granzyme A	Homo sapiens	207-217
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	granzyme A	Homo sapiens	219-223
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	Fas cell surface death receptor	Homo sapiens	289-293
21310942-3	2011	CPS treatment of 5637 cells induced upregulation of pro-angiogenetic (angiopoietin 1, angiopoietin 2 and vascular endothelial growth factor), pro-invasive and pro-metastatic genes (MMP1, MMP9, TIMP1, TIMP3, granzyme A (GZMA), NM23A and S100A) with a downregulation of apoptotic genes (Fas/CD95 and tumor necrosis factor receptor superfamily member 1A).	Capsaicin	0-3	TNF receptor superfamily member 1A	Homo sapiens	298-350
21310942-4	2011	CPS increased the invasiveness of 5637 cells by triggering IGF (insulin-like growth factor)-1 release, GZMA and MMP9 activation, alpha-tubulin disassembly and cytoskeleton degradation.	Capsaicin	0-3	granzyme A	Homo sapiens	103-107
21310942-4	2011	CPS increased the invasiveness of 5637 cells by triggering IGF (insulin-like growth factor)-1 release, GZMA and MMP9 activation, alpha-tubulin disassembly and cytoskeleton degradation.	Capsaicin	0-3	matrix metallopeptidase 9	Homo sapiens	112-116
21310942-6	2011	We found that TRPV1-expressing cells show CPS-mediated calcium level increase, growth inhibition and apoptosis.	Capsaicin	42-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	14-19
21310942-7	2011	Moreover, CPS-induced migration and MMP9 activation were reverted, suggesting an inhibitory role played by TRPV1 in urothelial cancer cell invasion and metastasis.	Capsaicin	10-13	matrix metallopeptidase 9	Homo sapiens	36-40
21310942-7	2011	Moreover, CPS-induced migration and MMP9 activation were reverted, suggesting an inhibitory role played by TRPV1 in urothelial cancer cell invasion and metastasis.	Capsaicin	10-13	transient receptor potential cation channel subfamily V member 1	Homo sapiens	107-112
21343315-8	2011	This study provides vital information on the molecular interactions of capsaicinoids with TRPV1 and substantiates TRPV1-mediated ER stress as a conserved mechanism of lung cell death by prototypical TRPV1 agonists.	Capsaicin	71-84	transient receptor potential cation channel subfamily V member 1	Homo sapiens	90-95
22321965-4	2011	Long-term exposures of trigeminal neurons to CM increased directly neuronal CGRP release, which was further enhanced by the exposure to capsaicin.	Capsaicin	136-145	calcitonin-related polypeptide alpha	Rattus norvegicus	76-80
21349818-1	2011	In addition to capsaicin, a transient receptor potential channel vanilloid subfamily 1 (TRPV1) agonist, two kinds of antagonists against this receptor are used as therapeutic drugs for pain relief.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-86
21349818-1	2011	In addition to capsaicin, a transient receptor potential channel vanilloid subfamily 1 (TRPV1) agonist, two kinds of antagonists against this receptor are used as therapeutic drugs for pain relief.	Capsaicin	15-24	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	88-93
21333704-7	2011	In addition, capsaicin significantly lowered the KA-induced increase in the concentration of the cytokines IL-1beta and TNF-alpha in the brain.	Capsaicin	13-22	tumor necrosis factor	Mus musculus	120-129
21527011-8	2011	Most IBA-responding neurons (71%) also responded to the TRPV1 agonist capsaicin, indicating that they were nociceptors.	Capsaicin	70-79	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
21364497-1	2011	BACKGROUND AND OBJECTIVES: Capsaicin selectively binds to TRPV1, the vanilloid subtype 1 of the superfamily of transient receptor potential ion channels, which is highly expressed in pain-transmitting C fibers.	Capsaicin	27-36	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	58-63
21364497-2	2011	Recent reports have demonstrated that the coadministration of capsaicin with a local anesthetic (LA) at the rat sciatic nerve elicits a prolonged nociceptive-selective nerve block, suggesting that activation of the TRPV1 receptor may allow LAs to enter the nerve through the TRPV1 pore.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	215-220
21364497-2	2011	Recent reports have demonstrated that the coadministration of capsaicin with a local anesthetic (LA) at the rat sciatic nerve elicits a prolonged nociceptive-selective nerve block, suggesting that activation of the TRPV1 receptor may allow LAs to enter the nerve through the TRPV1 pore.	Capsaicin	62-71	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	275-280
21364497-13	2011	CONCLUSIONS: This study demonstrates that the combined application of amitriptyline and capsaicin results in prolonged cutaneous analgesia compared with amitriptyline alone, suggesting that the activation of the TRPV1 channel by capsaicin facilitates the passage of amitriptyline into nociceptors.	Capsaicin	88-97	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	212-217
21364497-13	2011	CONCLUSIONS: This study demonstrates that the combined application of amitriptyline and capsaicin results in prolonged cutaneous analgesia compared with amitriptyline alone, suggesting that the activation of the TRPV1 channel by capsaicin facilitates the passage of amitriptyline into nociceptors.	Capsaicin	229-238	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	212-217
21490228-4	2011	Through the ex vivo superfusion of DHSC slices, we demonstrated that the rate of CCL2 secretion was much lower in neonatal capsaicin-treated rats than in controls.	Capsaicin	123-132	C-C motif chemokine ligand 2	Rattus norvegicus	81-85
21329730-2	2011	In the spinal cord, capsaicin significantly reduced TRPV1 and SP-ir (40-45%) in laminae I/II compared to controls, while RTX produced decreases of ~35%.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	52-57
21329730-7	2011	These data suggest that stimulation of TRPV1 by low dose vanilloid administration can rapidly (within 24h) alter both transcription and translation of TRPV1 channels, SP and NK1 receptors in the rat urinary bladder and spinal cord.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	39-44
21329730-7	2011	These data suggest that stimulation of TRPV1 by low dose vanilloid administration can rapidly (within 24h) alter both transcription and translation of TRPV1 channels, SP and NK1 receptors in the rat urinary bladder and spinal cord.	Capsaicin	57-66	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	151-156
21316356-5	2011	Many capsaicin-sensitive vagal afferents participate in peripheral satiety signaling that includes cholecystokinin (CCK) sensitive neurons.	Capsaicin	5-14	cholecystokinin	Homo sapiens	99-114
21316356-5	2011	Many capsaicin-sensitive vagal afferents participate in peripheral satiety signaling that includes cholecystokinin (CCK) sensitive neurons.	Capsaicin	5-14	cholecystokinin	Homo sapiens	116-119
21316356-9	2011	TRPA1 responses were mixed across neurons that were capsaicin-sensitive and -insensitive.	Capsaicin	52-61	transient receptor potential cation channel subfamily A member 1	Homo sapiens	0-5
21316356-10	2011	However CCK evoked inward currents only on capsaicin-sensitive neurons and 28% of the CCK-sensitive neurons expressed TRPA1.	Capsaicin	43-52	cholecystokinin	Homo sapiens	8-11
21609281-8	2011	Decreased activities of hepatic glutathione reductase and glutathione-S-transferase caused by the lithogenic diet were countered by the combination of capsaicin and curcumin.	Capsaicin	151-160	glutathione reductase	Mus musculus	32-53
21609281-8	2011	Decreased activities of hepatic glutathione reductase and glutathione-S-transferase caused by the lithogenic diet were countered by the combination of capsaicin and curcumin.	Capsaicin	151-160	hematopoietic prostaglandin D synthase	Mus musculus	58-83
21383497-4	2011	Nociceptor-specific deletion of GluA1 led to disruption of calcium permeability and reduced capsaicin-evoked activation of nociceptors.	Capsaicin	92-101	glutamate receptor, ionotropic, AMPA1 (alpha 1)	Mus musculus	32-37
21383046-6	2011	RESULTS: In vivo studies in monkeys and man showed that high doses compared to doses needed in vitro are needed to block capsaicin-induced in skin blood flow, a CGRP-mediated reaction.	Capsaicin	121-130	calcitonin related polypeptide alpha	Homo sapiens	161-165
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	Jun proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	33-38
21345654-1	2011	BACKGROUND: Transient receptor potential vanilloid type 1 (TRPV1) is a cation channel activated by diverse obnoxious stimuli like capsaicin, low pH or heat.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	12-57
21345654-1	2011	BACKGROUND: Transient receptor potential vanilloid type 1 (TRPV1) is a cation channel activated by diverse obnoxious stimuli like capsaicin, low pH or heat.	Capsaicin	130-139	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	59-64
21345654-4	2011	METHODS: TRPV1 antagonistic effects of PAC-14028 in human keratinocytes and skin were confirmed through capsaicin-evoked calcium influx assay and capsaicin-induced blood perfusion increase.	Capsaicin	104-113	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-14
21345654-4	2011	METHODS: TRPV1 antagonistic effects of PAC-14028 in human keratinocytes and skin were confirmed through capsaicin-evoked calcium influx assay and capsaicin-induced blood perfusion increase.	Capsaicin	146-155	transient receptor potential cation channel subfamily V member 1	Homo sapiens	9-14
21345654-8	2011	This potent TRPV1 antagonistic activity in keratinocytes was manifested in vivo as the blockade of capsaicin-induced blood perfusion increase, and the accelerated barrier recovery from tape-stripping-induced barrier damages in hairless mice.	Capsaicin	99-108	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	12-17
21462327-0	2011	Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.	Capsaicin	93-102	matrix metallopeptidase 9	Homo sapiens	52-78
21448716-4	2011	We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX).	Capsaicin	157-166	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	83-89
21448716-4	2011	We experimentally evaluated by mutational analysis the contribution of residues of rTRPV1 contributing to ligand binding by the prototypical TRPV1 agonists, capsaicin and resiniferatoxin (RTX).	Capsaicin	157-166	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	84-89
21448716-7	2011	Additionally, the binding mode of a simplified RTX (sRTX) ligand as predicted by the modeling agreed well with those of capsaicin and RTX, accounting for the high binding affinity of the sRTX ligand for TRPV1.	Capsaicin	120-129	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	203-208
21462327-0	2011	Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.	Capsaicin	93-102	epidermal growth factor receptor	Homo sapiens	125-129
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	Fos proto-oncogene, AP-1 transcription factor subunit	Homo sapiens	43-48
21462327-0	2011	Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.	Capsaicin	93-102	protein tyrosine kinase 2	Homo sapiens	139-142
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	epidermal growth factor receptor	Homo sapiens	126-138
21462327-0	2011	Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.	Capsaicin	93-102	AKT serine/threonine kinase 1	Homo sapiens	143-146
21462327-0	2011	Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.	Capsaicin	93-102	proline rich transmembrane protein 2	Homo sapiens	148-151
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	epidermal growth factor receptor	Homo sapiens	140-144
21462327-0	2011	Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.	Capsaicin	93-102	zinc fingers and homeoboxes 2	Homo sapiens	152-155
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	protein tyrosine kinase 2	Homo sapiens	147-168
21462327-0	2011	Suppression of EGF-induced tumor cell migration and matrix metalloproteinase-9 expression by capsaicin via the inhibition of EGFR-mediated FAK/Akt, PKC/Raf/ERK, p38 MAPK, and AP-1 signaling.	Capsaicin	93-102	mitogen-activated protein kinase 1	Homo sapiens	156-159
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	protein tyrosine kinase 2	Homo sapiens	170-173
21462327-5	2011	Capsaicin inhibited the epidermal growth factor (EGF)-induced activation of matrix metalloproteinase (MMP)-9 and MMP-2, and further inhibited cell invasion and migration.	Capsaicin	0-9	matrix metallopeptidase 9	Homo sapiens	76-108
21351130-4	2011	TRPV1 function was assessed by capsaicin (CAP, 6 microM)-evoked intracellular calcium ([Ca(2+)](i)) changes measured by microfluorimetry imaging.	Capsaicin	31-40	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
21351130-4	2011	TRPV1 function was assessed by capsaicin (CAP, 6 microM)-evoked intracellular calcium ([Ca(2+)](i)) changes measured by microfluorimetry imaging.	Capsaicin	42-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
21462327-5	2011	Capsaicin inhibited the epidermal growth factor (EGF)-induced activation of matrix metalloproteinase (MMP)-9 and MMP-2, and further inhibited cell invasion and migration.	Capsaicin	0-9	matrix metallopeptidase 2	Homo sapiens	113-118
21462327-6	2011	Capsaicin decreased the EGF-induced expression of MMP-9, MMP-2, and MT1-MMP, but did not alter TIMP-1 and TIMP-2 levels.	Capsaicin	0-9	matrix metallopeptidase 9	Homo sapiens	50-55
21462327-6	2011	Capsaicin decreased the EGF-induced expression of MMP-9, MMP-2, and MT1-MMP, but did not alter TIMP-1 and TIMP-2 levels.	Capsaicin	0-9	matrix metallopeptidase 2	Homo sapiens	57-62
21462327-6	2011	Capsaicin decreased the EGF-induced expression of MMP-9, MMP-2, and MT1-MMP, but did not alter TIMP-1 and TIMP-2 levels.	Capsaicin	0-9	matrix metallopeptidase 14	Homo sapiens	68-75
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	proline rich transmembrane protein 2	Homo sapiens	176-192
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	proline rich transmembrane protein 2	Homo sapiens	194-197
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta	Homo sapiens	200-229
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	AKT serine/threonine kinase 1	Homo sapiens	237-240
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	mitogen-activated protein kinase 3	Homo sapiens	242-281
21462327-7	2011	Capsaicin suppressed EGF-induced c-Jun and c-Fos nuclear translocation, and also abrogated the EGF-induced phosphorylation of EGF receptor (EGFR), focal adhesion kinase (FAK), protein kinase C (PKC), phosphatidylinositol 3-Kinase (PI3K)/Akt, extracellular regulated kinase (ERK)1/2, and JNK1/2, an upstream modulator of AP-1.	Capsaicin	0-9	mitogen-activated protein kinase 8	Homo sapiens	287-293
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	epidermal growth factor receptor	Homo sapiens	103-107
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	protein tyrosine kinase 2	Homo sapiens	118-121
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	AKT serine/threonine kinase 1	Homo sapiens	122-125
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	proline rich transmembrane protein 2	Homo sapiens	127-130
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	zinc fingers and homeoboxes 2	Homo sapiens	131-134
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	mitogen-activated protein kinase 1	Homo sapiens	135-138
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	mitogen-activated protein kinase 14	Homo sapiens	140-176
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	mitogen-activated protein kinase 3	Homo sapiens	178-182
21462327-9	2011	CONCLUSION: Capsaicin inhibited the EGF-induced invasion and migration of human fibrosarcoma cells via EGFR-dependent FAK/Akt, PKC/Raf/ERK, p38 mitogen-activated protein kinase (MAPK), and AP-1 signaling, leading to the down-regulation of MMP-9 expression.	Capsaicin	12-21	matrix metallopeptidase 9	Homo sapiens	239-244
21340460-6	2011	Epicardial application of capsaicin or PVN microinjection of angiotensin II (Ang II) increased c-Src activity more in 2K1C than Sham rats.	Capsaicin	26-35	angiotensinogen	Rattus norvegicus	77-83
21340460-6	2011	Epicardial application of capsaicin or PVN microinjection of angiotensin II (Ang II) increased c-Src activity more in 2K1C than Sham rats.	Capsaicin	26-35	SRC proto-oncogene, non-receptor tyrosine kinase	Rattus norvegicus	95-100
21131402-5	2011	Mucosal capsaicin (EC(50) = 19 muM) stimulated low rates of secretion that were partially inhibited by tetrodotoxin and by inhibitors for muscarinic, VIP, and SubP receptors, suggesting reflex stimulation of secretion by multiple transmitters.	Capsaicin	8-17	vasoactive intestinal peptide	Sus scrofa	150-153
21215315-6	2011	Accordingly, palvanil desensitized the human recombinant TRPV1 to the effect of capsaicin (10nM) with significantly higher potency than capsaicin (IC(50)=0.8nM and 3.8nM, respectively), this effect reaching its maximum more rapidly (50 and 250min, respectively).	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	57-62
21215315-7	2011	Palvanil was also more potent than capsaicin at desensitizing the stimulatory effect of TRPV1 by low pH together with anandamide, which mimics conditions occurring during inflammation.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	88-93
21215315-10	2011	In conclusion, palvanil appears to be a non-pungent analogue of capsaicin with stronger desensitizing effects on TRPV1 and hence potentially higher anti-hyperalgesic activity.	Capsaicin	64-73	transient receptor potential cation channel subfamily V member 1	Homo sapiens	113-118
20712533-5	2011	Trans-tympanic injections of capsaicin produced transient hearing loss within 24 h, which recovered by 72 h. In UB/OC-1 cells, capsaicin increased NOX3 NADPH oxidase activity and activation of signal transducer and activator of transcription 1 (STAT1).	Capsaicin	29-38	NADPH oxidase 3	Mus musculus	147-151
20712533-5	2011	Trans-tympanic injections of capsaicin produced transient hearing loss within 24 h, which recovered by 72 h. In UB/OC-1 cells, capsaicin increased NOX3 NADPH oxidase activity and activation of signal transducer and activator of transcription 1 (STAT1).	Capsaicin	29-38	signal transducer and activator of transcription 1	Mus musculus	193-243
20712533-5	2011	Trans-tympanic injections of capsaicin produced transient hearing loss within 24 h, which recovered by 72 h. In UB/OC-1 cells, capsaicin increased NOX3 NADPH oxidase activity and activation of signal transducer and activator of transcription 1 (STAT1).	Capsaicin	29-38	signal transducer and activator of transcription 1	Mus musculus	245-250
20712533-5	2011	Trans-tympanic injections of capsaicin produced transient hearing loss within 24 h, which recovered by 72 h. In UB/OC-1 cells, capsaicin increased NOX3 NADPH oxidase activity and activation of signal transducer and activator of transcription 1 (STAT1).	Capsaicin	127-136	NADPH oxidase 3	Mus musculus	147-151
20712533-5	2011	Trans-tympanic injections of capsaicin produced transient hearing loss within 24 h, which recovered by 72 h. In UB/OC-1 cells, capsaicin increased NOX3 NADPH oxidase activity and activation of signal transducer and activator of transcription 1 (STAT1).	Capsaicin	127-136	signal transducer and activator of transcription 1	Mus musculus	193-243
20712533-5	2011	Trans-tympanic injections of capsaicin produced transient hearing loss within 24 h, which recovered by 72 h. In UB/OC-1 cells, capsaicin increased NOX3 NADPH oxidase activity and activation of signal transducer and activator of transcription 1 (STAT1).	Capsaicin	127-136	signal transducer and activator of transcription 1	Mus musculus	245-250
20712533-6	2011	Intratympanic administration of capsaicin transiently increased STAT1 activity and expression of downstream proinflammatory molecules.	Capsaicin	32-41	signal transducer and activator of transcription 1	Rattus norvegicus	64-69
20712533-7	2011	Capsaicin produced a transient increase in CD14-positive inflammatory cells into the cochlea, which mimicked the temporal course of STAT1 activation but did not alter the expression of apoptotic genes or damage to outer hair cells.	Capsaicin	0-9	CD14 molecule	Rattus norvegicus	43-47
20712533-7	2011	Capsaicin produced a transient increase in CD14-positive inflammatory cells into the cochlea, which mimicked the temporal course of STAT1 activation but did not alter the expression of apoptotic genes or damage to outer hair cells.	Capsaicin	0-9	signal transducer and activator of transcription 1	Rattus norvegicus	132-137
20712533-8	2011	In addition, trans-tympanic administration of STAT1 short interfering RNA protected against capsaicin-induced hearing loss.	Capsaicin	92-101	signal transducer and activator of transcription 1	Rattus norvegicus	46-51
21385380-9	2011	Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression.	Capsaicin	31-40	microRNA 16-1	Mus musculus	74-87
21385380-9	2011	Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression.	Capsaicin	31-40	microRNA 206	Mus musculus	206-213
21385380-9	2011	Acute noxious stimulation with capsaicin also increased the expression of miR-1 and -16 in DRG cells but, on the other hand, in the spinal dorsal horn only a high dose of capsaicin was able to downregulate miR-206 expression.	Capsaicin	171-180	microRNA 206	Mus musculus	206-213
21178121-0	2011	Activation of CaMKII and ERK1/2 contributes to the time-dependent potentiation of Ca2+ response elicited by repeated application of capsaicin in rat DRG neurons.	Capsaicin	132-141	mitogen activated protein kinase 3	Rattus norvegicus	25-31
21215315-0	2011	N-palmitoyl-vanillamide (palvanil) is a non-pungent analogue of capsaicin with stronger desensitizing capability against the TRPV1 receptor and anti-hyperalgesic activity.	Capsaicin	64-73	transient receptor potential cation channel subfamily V member 1	Homo sapiens	125-130
21285946-3	2011	The mechanisms of heat and capsaicin activation have been linked to voltage-dependent gating in TRPV1.	Capsaicin	27-36	transient receptor potential cation channel subfamily V member 1	Homo sapiens	96-101
21131402-6	2011	Secretion in response to mucosal capsaicin was inhibited by CFTR(inh)-172, but not by niflumic acid.	Capsaicin	33-42	CF transmembrane conductance regulator	Sus scrofa	60-64
21125547-0	2011	Vanilloid derivatives as tyrosinase inhibitors driven by virtual screening-based QSAR models.	Capsaicin	0-9	tyrosinase	Homo sapiens	25-35
21156986-0	2011	Capsaicin indirectly suppresses voltage-gated Na+ currents through TRPV1 in rat dorsal root ganglion neurons.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	67-72
21156986-10	2011	CONCLUSION: The findings suggest that capsaicin decreases both TTX-s and TTX-r INa(+) as a result of an increase in [Na(+)]i through TRPV1.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	133-138
21176780-4	2011	Most of the PACAP-nerves were sensory, since they co-stored CGRP (calcitonin-gene-related peptide) and were sensitive to capsaicin-treatment.	Capsaicin	121-130	adenylate cyclase activating polypeptide 1	Rattus norvegicus	12-17
21098484-5	2011	Surprisingly, loss of MYCBP2 inhibited internalization of transient receptor potential vanilloid receptor 1 (TRPV1) and prevented desensitization of capsaicin-induced calcium increases.	Capsaicin	149-158	MYC binding protein 2, E3 ubiquitin protein ligase	Mus musculus	22-28
21164151-5	2011	Superoxide anion levels and NAD(P)H oxidase activity in the PVN increased in 2K1C rats and were much higher in 2K1C rats than in sham-operated (sham) rats after the epicardial application of capsaicin or PVN microinjection of ANG II.	Capsaicin	191-200	angiotensinogen	Rattus norvegicus	226-232
21332406-5	2011	Dietary capsaicin markedly decreased fasting glucose/insulin and triglyceride levels in the plasma and/or liver, as well as expression of inflammatory adipocytokine genes (e.g., monocyte chemoattractant protein-1 and interleukin-6) and macrophage infiltration.	Capsaicin	8-17	chemokine (C-C motif) ligand 2	Mus musculus	178-212
21332406-5	2011	Dietary capsaicin markedly decreased fasting glucose/insulin and triglyceride levels in the plasma and/or liver, as well as expression of inflammatory adipocytokine genes (e.g., monocyte chemoattractant protein-1 and interleukin-6) and macrophage infiltration.	Capsaicin	8-17	interleukin 6	Mus musculus	217-230
21332406-7	2011	These findings suggest that dietary capsaicin reduces metabolic dysregulation in obese/diabetic KKAy mice by enhancing expression of adiponectin and its receptor.	Capsaicin	36-45	adiponectin, C1Q and collagen domain containing	Mus musculus	133-144
21246380-2	2011	Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, is proposed to be involved in Dahl salt-sensitive hypertension, as determined in acute or short-term experiments.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-45
21246380-2	2011	Transient receptor potential vanilloid type 1 (TRPV1), a specific receptor for capsaicin, is proposed to be involved in Dahl salt-sensitive hypertension, as determined in acute or short-term experiments.	Capsaicin	79-88	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	47-52
21246380-3	2011	However, it remains unknown whether activation of TRPV1 by dietary capsaicin could prevent the vascular oxidative stress and hypertension induced by a high-salt diet.	Capsaicin	67-76	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	50-55
21246380-6	2011	However, chronic administration of capsaicin reduced the high-salt diet-induced endothelial dysfunction and nocturnal hypertension in part by preventing the generation of superoxide anions and NO reduction of mesenteric arteries through vascular TRPV1 activation.	Capsaicin	35-44	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	246-251
21246380-8	2011	TRPV1 activation through chronic dietary capsaicin may represent a promising lifestyle intervention in populations with salt-sensitive hypertension.	Capsaicin	41-50	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
21098091-5	2011	Although AS1928370 inhibited the capsaicin-induced Ca2(+) flux in human and rat TRPV1-expressing cells, the inhibitory effect on proton-induced Ca2(+) flux was extremely small.	Capsaicin	33-42	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	80-85
21115034-7	2011	Nevertheless, it was reduced in presence of capsazepine (10 or 20 mg/kg, s.c.) suggesting the participation of the TRPV1 receptor, which was reinforced when hesperidin significantly reduced the capsaicin-induced nociceptive response.	Capsaicin	194-203	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	115-120
21294877-2	2011	The promoter of TAC1 (TAC1prom) plays a central role in the regulation of the TAC1 gene but requires the presence of a second regulatory element; ECR2, to support TAC1 expression in sensory neurones and to respond appropriately to signalling pathways such as MAPkinases and noxious induction by capsaicin.	Capsaicin	295-304	tachykinin precursor 1	Homo sapiens	16-20
21294877-2	2011	The promoter of TAC1 (TAC1prom) plays a central role in the regulation of the TAC1 gene but requires the presence of a second regulatory element; ECR2, to support TAC1 expression in sensory neurones and to respond appropriately to signalling pathways such as MAPkinases and noxious induction by capsaicin.	Capsaicin	295-304	tachykinin precursor 1	Homo sapiens	22-26
21294877-2	2011	The promoter of TAC1 (TAC1prom) plays a central role in the regulation of the TAC1 gene but requires the presence of a second regulatory element; ECR2, to support TAC1 expression in sensory neurones and to respond appropriately to signalling pathways such as MAPkinases and noxious induction by capsaicin.	Capsaicin	295-304	tachykinin precursor 1	Homo sapiens	22-26
21294877-2	2011	The promoter of TAC1 (TAC1prom) plays a central role in the regulation of the TAC1 gene but requires the presence of a second regulatory element; ECR2, to support TAC1 expression in sensory neurones and to respond appropriately to signalling pathways such as MAPkinases and noxious induction by capsaicin.	Capsaicin	295-304	tachykinin precursor 1	Homo sapiens	22-26
21044673-1	2011	Capsaicin, the classic activator of TRPV-1 channels in primary sensory neurons, evokes nociception.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	36-42
21294877-4	2011	We demonstrate that TRPV1 is not expressed in all the same cells as SP following capsaicin induction suggesting the presence of a non-cell autonomous mechanism for TAC1 up-regulation following capsaicin induction.	Capsaicin	193-202	transient receptor potential cation channel subfamily V member 1	Homo sapiens	20-25
21294877-4	2011	We demonstrate that TRPV1 is not expressed in all the same cells as SP following capsaicin induction suggesting the presence of a non-cell autonomous mechanism for TAC1 up-regulation following capsaicin induction.	Capsaicin	193-202	tachykinin precursor 1	Homo sapiens	164-168
21294877-5	2011	In addition, we demonstrate that induction of SP and ECR1-TAC1prom activity in these larger diameter neurones can be induced by potassium depolarisation suggesting that, in addition to capsaicin induction, transgene activity may be modulated by voltage gated calcium channels.	Capsaicin	185-194	tachykinin precursor 1	Homo sapiens	58-62
21294877-6	2011	Furthermore, we show that NK1 is expressed in all SP- expressing cells after capsaicin induction and that an agonist of NK1 can activate both SP and the transgene in larger diameter neurones.	Capsaicin	77-86	tachykinin receptor 1	Homo sapiens	26-29
21344007-13	2011	The effect of CCK on food intake was restored by 300-days post-capsaicin.	Capsaicin	63-72	cholecystokinin	Rattus norvegicus	14-17
21725760-1	2011	Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-53
21056583-4	2011	We also examined xenon"s effect on the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) in the rat spinal dorsal horn evoked by hind-paw injection of capsaicin.	Capsaicin	171-180	mitogen activated protein kinase 3	Rattus norvegicus	58-99
21056583-4	2011	We also examined xenon"s effect on the phosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2) in the rat spinal dorsal horn evoked by hind-paw injection of capsaicin.	Capsaicin	171-180	mitogen activated protein kinase 3	Rattus norvegicus	101-107
21056583-5	2011	KEY FINDINGS: Xenon (75%) reduced the number of primary sensory neurons responding to the TRPV1 agonist, capsaicin (100 nM-1 muM) by ~25% to ~50%.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	90-95
21056583-6	2011	Xenon reduced the number of heterologously-expressed hTRPV1 activated by 300 nM capsaicin by ~50%.	Capsaicin	80-89	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-59
21056583-7	2011	Xenon (80%) reduced by ~40% the number of phosphorylated ERK1/2-expressing neurons in rat spinal dorsal horn resulting from hind-paw capsaicin injection.	Capsaicin	133-142	mitogen activated protein kinase 3	Rattus norvegicus	57-63
21034170-4	2011	RESULTS: The control group showed a cough reflex at a capsaicin concentration of 2.61 muM (0.98-7.80), while patients with mild dysphagia did so at 7.28 muM (1.95-15.6), those with moderate dysphagia at 22.07 muM (15.6-62.5), and those with severe dysphagia at 71.75 muM (31.2-250).	Capsaicin	54-63	latexin	Homo sapiens	86-89
20692381-4	2011	Our results showed that 30min after IL-1beta injection (2-6 mug kg-1), SP levels and Evans blue extravasation in bronchoalveolar lavage fluid were markedly increased and these responses were eliminated or largely reduced in neonatal capsaicin-treated rats.	Capsaicin	233-242	interleukin 1 beta	Rattus norvegicus	36-44
21114980-7	2011	Pretreatment with capsazepine, a TRPV1 antagonist, significantly decreased capsaicin-evoked EMG activity in both streptozotocin-treated and control rats.	Capsaicin	75-84	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	33-38
21068392-12	2011	In summary, our results demonstrate that the rise in [Ca(2+)](i) in sensory neurons by glutamate and capsaicin causes intracellular acidification by activation of PMCA type 3, that the pH(i) recovery from acidification is mediated by membrane transporters NHE1 and pNBC1 specifically, and that the activity of these transporters has direct consequences for neuronal excitability.	Capsaicin	101-110	solute carrier family 9 member A1	Rattus norvegicus	256-260
21056583-8	2011	SIGNIFICANCE: Xenon substantially reduces the activity of TRPV1 in response to noxious stimulation by the specific TRPV1 agonist, capsaicin, suggesting a possible role for xenon as an adjunct analgesic where hTRPV1 is an active contributor to the excitation of primary afferents which initiates the pain sensation.	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	58-63
21056583-8	2011	SIGNIFICANCE: Xenon substantially reduces the activity of TRPV1 in response to noxious stimulation by the specific TRPV1 agonist, capsaicin, suggesting a possible role for xenon as an adjunct analgesic where hTRPV1 is an active contributor to the excitation of primary afferents which initiates the pain sensation.	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	115-120
21056583-8	2011	SIGNIFICANCE: Xenon substantially reduces the activity of TRPV1 in response to noxious stimulation by the specific TRPV1 agonist, capsaicin, suggesting a possible role for xenon as an adjunct analgesic where hTRPV1 is an active contributor to the excitation of primary afferents which initiates the pain sensation.	Capsaicin	130-139	transient receptor potential cation channel subfamily V member 1	Homo sapiens	208-214
21249195-0	2011	Capsaicin-induced changes in LTP in the lateral amygdala are mediated by TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
21249195-1	2011	The transient receptor potential vanilloid type 1 (TRPV1) channel is a well recognized polymodal signal detector that is activated by painful stimuli such as capsaicin.	Capsaicin	158-167	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	4-49
21249195-1	2011	The transient receptor potential vanilloid type 1 (TRPV1) channel is a well recognized polymodal signal detector that is activated by painful stimuli such as capsaicin.	Capsaicin	158-167	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	51-56
21249195-6	2011	The capsaicin-induced reduction of LTP was completely blocked by the nitric oxide synthase (NOS) inhibitor L-NAME and was absent in neuronal NOS as well as in TRPV1 deficient mice.	Capsaicin	4-13	nitric oxide synthase 1, neuronal	Mus musculus	69-90
21249195-6	2011	The capsaicin-induced reduction of LTP was completely blocked by the nitric oxide synthase (NOS) inhibitor L-NAME and was absent in neuronal NOS as well as in TRPV1 deficient mice.	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	159-164
21249195-7	2011	The specific antagonist of cannabinoid receptor type 1 (CB1), AM 251, was also able to reduce the inhibitory effect of capsaicin on LA-LTP, suggesting that stimulation of TRPV1 provokes the generation of anandamide in the brain which seems to inhibit NO synthesis.	Capsaicin	119-128	cannabinoid receptor 1 (brain)	Mus musculus	27-59
21249195-7	2011	The specific antagonist of cannabinoid receptor type 1 (CB1), AM 251, was also able to reduce the inhibitory effect of capsaicin on LA-LTP, suggesting that stimulation of TRPV1 provokes the generation of anandamide in the brain which seems to inhibit NO synthesis.	Capsaicin	119-128	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	171-176
21249195-8	2011	After isoflurane anesthesia before euthanasia capsaicin caused a TRPV1-mediated increase in the magnitude of LA-LTP.	Capsaicin	46-55	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	65-70
21725760-1	2011	Capsaicin, a transient receptor potential vanilloid 1 (TRPV1) agonist, has recently been shown to provide neuroprotection against brain injury in experimental adult models of cerebral ischemia.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	55-60
21725760-2	2011	Accordingly, in this study, we investigated the way in which capsaicin-mediated TRPV1 modulation could attenuate damage in an experimental hypoxic-ischemic (HI) neonatal brain injury model.	Capsaicin	61-70	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	80-85
20932251-3	2011	Depending on the duration of capsaicin exposure and the external calcium concentration, the Ca(2+) influx via TRPV1 channels desensitizes the channels themselves, which, from the cellular point of view, represents a feedback mechanism protecting the nociceptive neuron from toxic Ca(2+) overload.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	110-115
21157928-8	2011	Double-immunofluorescence staining for neural beta III tubulin and CGRP revealed that the majority of the remaining fibers in the epidermis after capsaicin treatment were of peptidergic type.	Capsaicin	146-155	calcitonin-related polypeptide alpha	Rattus norvegicus	67-71
21169799-7	2011	Inhibition of PKA activity and disruption of PKA-A kinase-anchoring protein interaction in the DH (2.0 +- 0.6 and 16.7 +- 2.8 spikes/stimulation, respectively) are sufficient to prevent capsaicin-dependent reflex sensitization and AMPAR trafficking in the membrane fraction (0.6- and 0.5-fold increase capsaicin).	Capsaicin	186-195	A-kinase anchoring protein 13	Homo sapiens	49-75
21597186-1	2011	The administration of such a transient receptor potential vanilloid 1 (TRPV1) agonist as capsaicin, which is a pungent ingredient of red pepper, promotes energy metabolism and suppresses visceral fat accumulation.	Capsaicin	89-98	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-69
21597186-1	2011	The administration of such a transient receptor potential vanilloid 1 (TRPV1) agonist as capsaicin, which is a pungent ingredient of red pepper, promotes energy metabolism and suppresses visceral fat accumulation.	Capsaicin	89-98	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	71-76
21597186-6	2011	MGs that activated TRPV1 also therefore induced the expression of UCP 1 and prevented visceral fat accumulation as well as capsaicin.	Capsaicin	123-132	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	19-24
20932253-1	2011	The transient receptor potential vanilloid type 1 ion channel (TRPV1) was identified as a receptor responsible for mediating the intense burning sensation following exposure to heat greater than approximately 43 C., or capsaicin, the pungent ingredient of hot chilli peppers.	Capsaicin	219-228	transient receptor potential cation channel subfamily V member 1	Homo sapiens	63-68
20932253-5	2011	The widespread expression of TRPV1 in the human suggests that, in addition to the development of burning pain associated with acute exposure to heat or capsaicin, and with inflammation, TRPV1 may also be involved in an array of vitally important functions, such as those of the urinary tract, the respiratory and auditory systems.	Capsaicin	152-161	transient receptor potential cation channel subfamily V member 1	Homo sapiens	29-34
21146075-3	2011	In vitro studies conducted with cultures of rat trigeminal neurons demonstrated that pretreatment with LPS produced a significant increase in the capsaicin-evoked release of calcitonin gene-related peptide (CGRP) when compared with vehicle pretreatment, thus showing sensitization of the capsaicin receptor, TRPV1, by LPS.	Capsaicin	146-155	calcitonin-related polypeptide alpha	Rattus norvegicus	174-205
21671878-4	2011	This has rekindled interest in desensitization of nociceptive neurons to TRPV1 agonists (e.g. capsaicin and its ultrapotent analog resiniferatoxin) as an alternative pharmacological approach to block pain in the periphery where it is generated.	Capsaicin	94-103	transient receptor potential cation channel subfamily V member 1	Homo sapiens	73-78
21158551-5	2011	The action of capsaicin on the transient receptor potential cation channel, subfamily V, member 1 receptors will be discussed.	Capsaicin	14-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-97
22389862-0	2011	Study on HIF-1alpha Gene Translation in Psoriatic Epidermis with the Topical Treatment of Capsaicin Ointment.	Capsaicin	90-99	hypoxia inducible factor 1 subunit alpha	Homo sapiens	9-19
22389862-4	2011	HIF-1alpha gene translation in active psoriatic lesions before and after 21-day treatment with capsaicin ointment was detected by in situ hybridization.	Capsaicin	95-104	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
22389862-6	2011	There was positive staining of HIF-1alpha gene in all the layers of psoriatic epidermis (100.0%) before the treatment with capsaicin ointment, but the dyeing in epidermis were reduced obviously (22.2%) after the treatment for 21 days.	Capsaicin	123-132	hypoxia inducible factor 1 subunit alpha	Homo sapiens	31-41
22389862-8	2011	HIF-1alpha gene translation in psoriatic epidermis was downregulated after capsaicin treatment for 21 days.	Capsaicin	75-84	hypoxia inducible factor 1 subunit alpha	Homo sapiens	0-10
21042867-2	2011	In the present study, we investigated the effect of an extract of V. africana and its constituents on smooth muscle contraction induced by capsaicin in mouse rectum, where transient receptor potential vanilloid type 1 (TRPV1)-immunoreactive fibers are abundant.	Capsaicin	139-148	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	172-217
21042867-2	2011	In the present study, we investigated the effect of an extract of V. africana and its constituents on smooth muscle contraction induced by capsaicin in mouse rectum, where transient receptor potential vanilloid type 1 (TRPV1)-immunoreactive fibers are abundant.	Capsaicin	139-148	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	219-224
21042867-7	2011	The capsaicin-induced contraction was almost completely inhibited by the TRPV1 antagonist, N-(4-tertiarybutylphenyl)-4-(3-chloropyridin-2-yl)tetrahydropyrazine-1(2H)-carbox-amide (BCTC).	Capsaicin	4-13	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
22090803-8	2011	Functional effects included dose-related inhibition of capsaicin responses on calcium imaging after acute treatment with botulinum neurotoxins A and E. CONCLUSION: Differential levels of SV2A protein expression in clinical disorders may identify potential new targets for botulinum neurotoxin therapy.	Capsaicin	55-64	synaptic vesicle glycoprotein 2A	Homo sapiens	187-191
21591901-11	2011	With this information, it has been possible to develop a TRPV1 compound that blocks responses to capsaicin and acid while leaving temperature sensitivity intact.	Capsaicin	97-106	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	57-62
21042867-9	2011	These results suggest that Iboga-type alkaloids isolated from V. africana inhibit capsaicin-induced contraction in the mouse rectum, possibly via the inhibition of a TRPV1-mediated pathway.	Capsaicin	82-91	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	166-171
21146075-3	2011	In vitro studies conducted with cultures of rat trigeminal neurons demonstrated that pretreatment with LPS produced a significant increase in the capsaicin-evoked release of calcitonin gene-related peptide (CGRP) when compared with vehicle pretreatment, thus showing sensitization of the capsaicin receptor, TRPV1, by LPS.	Capsaicin	146-155	calcitonin-related polypeptide alpha	Rattus norvegicus	207-211
21146075-3	2011	In vitro studies conducted with cultures of rat trigeminal neurons demonstrated that pretreatment with LPS produced a significant increase in the capsaicin-evoked release of calcitonin gene-related peptide (CGRP) when compared with vehicle pretreatment, thus showing sensitization of the capsaicin receptor, TRPV1, by LPS.	Capsaicin	146-155	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	288-306
21146075-3	2011	In vitro studies conducted with cultures of rat trigeminal neurons demonstrated that pretreatment with LPS produced a significant increase in the capsaicin-evoked release of calcitonin gene-related peptide (CGRP) when compared with vehicle pretreatment, thus showing sensitization of the capsaicin receptor, TRPV1, by LPS.	Capsaicin	146-155	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	308-313
20883741-7	2011	We found that CST and SST do not modify basal CGRP secretion from trigeminal neurons, but both peptides were able to inhibit in a concentration-dependent manner the release of CGRP stimulated by KCl, veratridine or capsaicin.	Capsaicin	215-224	calcitonin-related polypeptide alpha	Rattus norvegicus	176-180
21258172-7	2011	The administration of a pastille with capsaicin as an agonist stimulus of TRPV1, a warm-temperature receptor, decreased the delay in swallowing reflex.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	90-135
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	137-141
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	NFKB inhibitor alpha	Homo sapiens	229-312
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	NFKB inhibitor alpha	Homo sapiens	314-326
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	protein kinase C delta	Homo sapiens	359-367
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	interleukin 6	Homo sapiens	387-391
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	9-18	C-X-C motif chemokine ligand 8	Homo sapiens	396-400
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	transient receptor potential cation channel subfamily V member 1	Homo sapiens	37-42
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	90-135
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	mitogen-activated protein kinase kinase kinase 7	Homo sapiens	137-141
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	NFKB inhibitor alpha	Homo sapiens	229-312
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	NFKB inhibitor alpha	Homo sapiens	314-326
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	protein kinase C delta	Homo sapiens	359-367
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	interleukin 6	Homo sapiens	387-391
22171160-7	2011	RESULTS: Capsaicin (CAP; a selective TRPV1 agonist), induced time-dependent activation of transforming growth factor-activated kinase 1 (TAK1) and mitogen-activated protein kinase (MAPK) cascades temporally followed by increased nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha (IkappaBalpha) phosphorylation, rises in both PKCdelta protein levels and IL-6 and IL-8 release.	Capsaicin	20-23	C-X-C motif chemokine ligand 8	Homo sapiens	396-400
32272547-7	2011	The administration of a pastille with capsaicin as an agonist stimulus of TRPV1, a warm-temperature receptor, decreased the delay in swallowing reflex.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	74-79
21954707-0	2011	[Changes the TRPV1-immunoreactive neurons of the rat spinal nerve sensory ganglia induced by capsaicin].	Capsaicin	93-102	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-18
21954707-3	2011	Capsaicin treatment of newborn rats was shown to change age dynamics of TRPV1-positive neurons resulting in the reduction of the average cell cross-sectional area and cell numbers during the whole period of observation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	72-77
20924599-1	2011	Acid-sensing ion channels (ASICs) are neuronal H(+)-gated cation channels, and the transient receptor potential vanilloid 1 channel (TRPV1) is a multimodal cation channel activated by low pH, noxious heat, capsaicin, and voltage.	Capsaicin	206-215	transient receptor potential cation channel subfamily V member 1	Homo sapiens	133-138
21430411-0	2011	Effects of systemic capsaicin treatment on TRPV1 and Tachykinin NK(1) receptor distribution and function in the nucleus of the solitary tract of the adult rat.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	43-48
21346393-1	2011	Capsaicin, a vanilloid, has the potential for releasing substance P (SP) from sensory nerves.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	56-67
21346393-1	2011	Capsaicin, a vanilloid, has the potential for releasing substance P (SP) from sensory nerves.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	69-71
21346393-1	2011	Capsaicin, a vanilloid, has the potential for releasing substance P (SP) from sensory nerves.	Capsaicin	13-22	tachykinin precursor 1	Homo sapiens	56-67
21346393-1	2011	Capsaicin, a vanilloid, has the potential for releasing substance P (SP) from sensory nerves.	Capsaicin	13-22	tachykinin precursor 1	Homo sapiens	69-71
21430411-0	2011	Effects of systemic capsaicin treatment on TRPV1 and Tachykinin NK(1) receptor distribution and function in the nucleus of the solitary tract of the adult rat.	Capsaicin	20-29	tachykinin receptor 1	Rattus norvegicus	64-78
21430411-2	2011	We have previously shown that systemic capsaicin administration to neonatal rats evokes profound long-term alterations in transient receptor potential vanilloid 1 (TRPV1)- and neurokinin 1 (NK(1)) receptor-mediated respiratory responses in the commissural nucleus of the solitary tract (cNTS).	Capsaicin	39-48	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	164-169
21430411-2	2011	We have previously shown that systemic capsaicin administration to neonatal rats evokes profound long-term alterations in transient receptor potential vanilloid 1 (TRPV1)- and neurokinin 1 (NK(1)) receptor-mediated respiratory responses in the commissural nucleus of the solitary tract (cNTS).	Capsaicin	39-48	tachykinin receptor 1	Rattus norvegicus	176-205
21430411-7	2011	Systemic capsaicin pretreatment significantly (p &lt; 0.05) reduced the density of both [(125)I]Bolton-Hunter SP binding sites (NK(1) receptors) and NK(1) receptor immunoreactivity in the cNTS, but did not alter the respiratory responses evoked by microinjection of [Sar(9), Met(O(2))(11)]SP and septide into this region.	Capsaicin	9-18	tachykinin receptor 1	Rattus norvegicus	128-163
21430411-8	2011	These studies show that systemic capsaicin administration reduces NK(1) receptor density in the cNTS without adversely affecting NK(1) receptor function at this site.	Capsaicin	33-42	tachykinin receptor 1	Rattus norvegicus	66-80
21991351-7	2011	Treatment with CSD reversed the capsaicin-induced RSNA and MAP changes and the CSAR responses to Ang II in both Sham and CHF rats, and reduced the RSNA and MAP responses to Ang II only in CHF rats.	Capsaicin	32-41	angiotensinogen	Rattus norvegicus	97-103
22216270-1	2011	BACKGROUND: Previous studies have demonstrated that QX-314, an intracellular sodium channel blocker, can enter into nociceptors through capsaicin-activated TRPV1 or permeation of the membrane by chemical enhancers to produce a sensory-selective blockade.	Capsaicin	136-145	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	156-161
21949835-7	2011	The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	4-9
21949835-7	2011	The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
21949835-7	2011	The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
21949835-7	2011	The TRPV1 agonist capsaicin (100 nM) blocked the evoked TRPV1+ ST-EPSCs and defined them as either TRPV1+ or TRPV1- inputs.	Capsaicin	18-27	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	56-61
21949835-9	2011	Since TRPV1 mediates asynchronous release following TRPV1+ ST-evoked EPSCs, we likewise found that recruiting more than one ST afferent further augmented the asynchronous response and was eliminated by capsaicin.	Capsaicin	202-211	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	6-11
21949864-6	2011	Furthermore, mice heterozygous for Type III Nrg1 have specific deficits in their ability to respond to noxious thermal stimuli and to develop capsaicin-induced thermal hypersensitivity to pain.	Capsaicin	142-151	neuregulin 1	Mus musculus	44-48
21167052-1	2010	BACKGROUND: Ablation of TRPV1-expressing nociceptive fibers with the potent capsaicin analog resiniferatoxin (RTX) results in long lasting pain relief.	Capsaicin	76-85	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	24-29
21779403-10	2011	Furthermore, we found that protons and capsaicin likewise synergistically potentiated the response of TRPV1 to hypertonic stimuli.	Capsaicin	39-48	transient receptor potential cation channel subfamily V member 1	Homo sapiens	102-107
21647434-5	2011	Our results shows that capsaicin inhibits about 2.5-9% and 5-20% of complex-I activity and 8-75% of complex-III activity in BxPC-3 and AsPC-1 cells respectively, which was attenuable by SOD, catalase and EUK-134.	Capsaicin	23-32	superoxide dismutase 1	Homo sapiens	186-189
21647434-5	2011	Our results shows that capsaicin inhibits about 2.5-9% and 5-20% of complex-I activity and 8-75% of complex-III activity in BxPC-3 and AsPC-1 cells respectively, which was attenuable by SOD, catalase and EUK-134.	Capsaicin	23-32	catalase	Homo sapiens	191-199
21647434-11	2011	Our results further demonstrate that capsaicin treatment not only inhibit the enzymatic activity and expression of SOD, catalase and glutathione peroxidase but also reduce glutathione level.	Capsaicin	37-46	superoxide dismutase 1	Homo sapiens	115-118
21647434-11	2011	Our results further demonstrate that capsaicin treatment not only inhibit the enzymatic activity and expression of SOD, catalase and glutathione peroxidase but also reduce glutathione level.	Capsaicin	37-46	catalase	Homo sapiens	120-128
21647434-12	2011	Over-expression of catalase by transient transfection protected the cells from capsaicin-mediated ROS generation and apoptosis.	Capsaicin	79-88	catalase	Homo sapiens	19-27
21647434-13	2011	Furthermore, tumors from mice orally fed with 2.5 mg/kg capsaicin show decreased SOD activity and an increase in GSSG/GSH levels as compared to controls.	Capsaicin	56-65	superoxide dismutase 1	Homo sapiens	81-84
21044960-1	2010	The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3.	Capsaicin	190-199	transient receptor potential cation channel subfamily V member 1	Homo sapiens	51-56
21044960-1	2010	The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3.	Capsaicin	190-199	arginyl aminopeptidase	Homo sapiens	293-296
21044960-1	2010	The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3.	Capsaicin	190-199	transient receptor potential cation channel subfamily V member 1	Homo sapiens	372-377
21044960-1	2010	The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3.	Capsaicin	190-199	transient receptor potential cation channel subfamily V member 2	Homo sapiens	379-384
21044960-1	2010	The vanilloid transient receptor potential channel TRPV1 is a tetrameric six-transmembrane segment (S1-S6) channel that can be synergistically activated by various proalgesic agents such as capsaicin, protons, heat, or highly depolarizing voltages, and also by 2-aminoethoxydiphenyl borate (2-APB), a common activator of the related thermally gated vanilloid TRP channels TRPV1, TRPV2, and TRPV3.	Capsaicin	190-199	transient receptor potential cation channel subfamily V member 3	Homo sapiens	390-395
21044960-4	2010	We mutated charged residues all along the S4 and the S4-S5 linker of TRPV1 and identified four potential voltage-sensing residues (Arg(557), Glu(570), Asp(576), and Arg(579)) that, when specifically mutated, altered the functionality of the channel with respect to voltage, capsaicin, heat, 2-APB, and/or their interactions in different ways.	Capsaicin	274-283	transient receptor potential cation channel subfamily V member 1	Homo sapiens	69-74
20870010-7	2010	In contrast to the ability of chronic NGF to increase peptide content, acute exposure of sensory neurons to 100 ng/mL NGF augments capsaicin-evoked release of CGRP without affecting the content of CGRP.	Capsaicin	131-140	calcitonin related polypeptide alpha	Homo sapiens	159-163
20870010-9	2010	In contrast, the NGF-induced increase in capsaicin-evoked release of CGRP is blocked by the protein kinase C (PKC) inhibitor, BIM and the Src family kinases inhibitor, PP2.	Capsaicin	41-50	calcitonin related polypeptide alpha	Homo sapiens	69-73
20870010-9	2010	In contrast, the NGF-induced increase in capsaicin-evoked release of CGRP is blocked by the protein kinase C (PKC) inhibitor, BIM and the Src family kinases inhibitor, PP2.	Capsaicin	41-50	neuropeptide Y receptor Y6 (pseudogene)	Homo sapiens	168-171
20870010-10	2010	These data demonstrate that different signaling pathways mediate the alterations in expression of CGRP by chronic NGF and the acute actions of the neurotrophin to augment capsaicin-evoked release of CGRP in the absence of a change in the content of the peptide.	Capsaicin	171-180	calcitonin related polypeptide alpha	Homo sapiens	98-102
20870010-10	2010	These data demonstrate that different signaling pathways mediate the alterations in expression of CGRP by chronic NGF and the acute actions of the neurotrophin to augment capsaicin-evoked release of CGRP in the absence of a change in the content of the peptide.	Capsaicin	171-180	brain derived neurotrophic factor	Homo sapiens	147-159
20870010-10	2010	These data demonstrate that different signaling pathways mediate the alterations in expression of CGRP by chronic NGF and the acute actions of the neurotrophin to augment capsaicin-evoked release of CGRP in the absence of a change in the content of the peptide.	Capsaicin	171-180	calcitonin related polypeptide alpha	Homo sapiens	199-203
20804493-5	2010	CGRP was depleted using repetitive challenges of capsaicin.	Capsaicin	49-58	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
20804493-8	2010	KEY RESULTS: Capsaicin-induced CGRP release was attenuated by the transient receptor potential vanilloid receptor type I antagonist capsazepine or by Ca(2+)-free solutions.	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	31-35
20804493-9	2010	After the CGRP-depleted preparation had been exposed to exogenous CGRP, capsaicin-induced CGRP release was increased compared to the challenge just prior to incubation.	Capsaicin	72-81	calcitonin-related polypeptide alpha	Rattus norvegicus	10-14
20804493-9	2010	After the CGRP-depleted preparation had been exposed to exogenous CGRP, capsaicin-induced CGRP release was increased compared to the challenge just prior to incubation.	Capsaicin	72-81	calcitonin-related polypeptide alpha	Rattus norvegicus	66-70
20804493-9	2010	After the CGRP-depleted preparation had been exposed to exogenous CGRP, capsaicin-induced CGRP release was increased compared to the challenge just prior to incubation.	Capsaicin	72-81	calcitonin-related polypeptide alpha	Rattus norvegicus	66-70
21123568-6	2010	Importantly, directly elevating spiking in individual postsynaptic neurons, by capsaicin activation of overexpressed TRPV1 channels, was sufficient to induce increased mIPSC amplitude and frequency, mimicking the effect of elevated neuronal activity.	Capsaicin	79-88	transient receptor potential cation channel subfamily V member 1	Homo sapiens	117-122
21143657-9	2010	Thus, magnocellular neurosecretory neurons appear to express an N-terminal variant of trpv1 which lacks sensitivity to capsaicin, but which enables osmosensing and thermosensing.	Capsaicin	119-128	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
20935279-5	2010	Laser irradiation attenuated TRPV1 activation by capsaicin in Ca(2+) imaging experiments with TRPV1-overexpressing cells and cultured trigeminal neurons.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	29-34
20935279-5	2010	Laser irradiation attenuated TRPV1 activation by capsaicin in Ca(2+) imaging experiments with TRPV1-overexpressing cells and cultured trigeminal neurons.	Capsaicin	49-58	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	94-99
20950340-5	2010	Stimulation for 1 h with the transient receptor potential vanilloid-1 channel agonist capsaicin (100 nmol/L) or depolarizing K(+) (60 mmol/L) increased CGRP release as measured by ELISA.	Capsaicin	86-95	calcitonin-related polypeptide alpha	Rattus norvegicus	152-156
20950340-8	2010	14,15-EEZE likewise attenuated capsaicin-evoked CGRP release from trigeminal ganglion neurons (p &lt; 0.05 anova, n = 6).	Capsaicin	31-40	calcitonin-related polypeptide alpha	Rattus norvegicus	48-52
20863199-0	2010	Inhibition and induction of human cytochrome P450 enzymes in vitro by capsaicin.	Capsaicin	70-79	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	34-49
20657161-5	2010	Regardless of the treatment with NGF, about half of the neurons responded to capsaicin and 10% of the neurons responded to icilin, and almost all icilin-responding neurons also responded to capsaicin.	Capsaicin	77-86	nerve growth factor	Rattus norvegicus	33-36
20657161-8	2010	The degree of the [Ca(2+)](i) fluctuations in the NGF-treated neurons responding to both capsaicin and icilin was significantly larger than in other neurons.	Capsaicin	89-98	nerve growth factor	Rattus norvegicus	50-53
20657161-9	2010	These results suggest that neurons expressing both capsaicin- and icilin-sensitive TRP channels are susceptible to NGF and become hyperexcitable and that Ca(2+) influx through voltage-gated Ca(2+) channels is the major source contributing to the [Ca(2+)](i) fluctuations.	Capsaicin	51-60	nerve growth factor	Rattus norvegicus	115-118
20863199-2	2010	To investigate potential food-drug or drug-drug interactions, capsaicin was evaluated in vitro against seven human drug-metabolizing cytochrome P450 (CYP) enzymes.	Capsaicin	62-71	cytochrome P450 family 4 subfamily F member 3	Homo sapiens	150-153
20826151-7	2010	These results indicate that visceral hypersensitivity induced by TRPV1 activation is modulated through 5-HT pathways and the attenuated function of TRPV1 and decreased protein expression of pCaMKII may play an important role in capsaicin-induced TRPV1 desensitization under 5-HT-depleted condition.	Capsaicin	228-237	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	65-70
20826151-7	2010	These results indicate that visceral hypersensitivity induced by TRPV1 activation is modulated through 5-HT pathways and the attenuated function of TRPV1 and decreased protein expression of pCaMKII may play an important role in capsaicin-induced TRPV1 desensitization under 5-HT-depleted condition.	Capsaicin	228-237	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	148-153
20863199-9	2010	10 muM capsaicin caused a statistically significant increase in CYP1A2 activity (8.6% of the positive control).	Capsaicin	7-16	cytochrome P450 family 1 subfamily A member 2	Homo sapiens	64-70
20826151-7	2010	These results indicate that visceral hypersensitivity induced by TRPV1 activation is modulated through 5-HT pathways and the attenuated function of TRPV1 and decreased protein expression of pCaMKII may play an important role in capsaicin-induced TRPV1 desensitization under 5-HT-depleted condition.	Capsaicin	228-237	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	148-153
20863199-11	2010	Although pre-incubation did enhance the potency for CYP2B6 inhibition to 5.1 muM, given that exposure to capsaicin from either food or a topical medicine is very low (&lt;=58 nM) and transient, effects on CYPs appear unlikely.	Capsaicin	105-114	cytochrome P450 family 2 subfamily B member 6	Homo sapiens	52-58
20223533-2	2010	The hypertensive response was explained on the basis of decreased vasodilator substance calcitonin gene-related peptide (CGRP) from sensory nerve terminals by capsaicin.	Capsaicin	159-168	calcitonin related polypeptide alpha	Homo sapiens	88-119
20223533-2	2010	The hypertensive response was explained on the basis of decreased vasodilator substance calcitonin gene-related peptide (CGRP) from sensory nerve terminals by capsaicin.	Capsaicin	159-168	calcitonin related polypeptide alpha	Homo sapiens	121-125
20832068-2	2010	Calcitonin gene-related peptide (CGRP), a major neurotransmitter of the capsaicin-sensitive sensory nerves, protects endothelial function.	Capsaicin	72-81	calcitonin related polypeptide alpha	Homo sapiens	0-31
20937561-0	2010	Halogenation of 4-hydroxy/amino-3-methoxyphenyl acetamide TRPV1 agonists showed enhanced antagonism to capsaicin.	Capsaicin	103-112	LOW QUALITY PROTEIN: transient receptor potential cation channel subfamily V member 1	Cricetulus griseus	58-63
20832068-2	2010	Calcitonin gene-related peptide (CGRP), a major neurotransmitter of the capsaicin-sensitive sensory nerves, protects endothelial function.	Capsaicin	72-81	calcitonin related polypeptide alpha	Homo sapiens	33-37
20198432-15	2010	CGRP secreted by activated capsaicin-sensitive neurons played an important role in the protective effects of genistein.	Capsaicin	27-36	calcitonin-related polypeptide alpha	Rattus norvegicus	0-4
20626462-4	2010	Furthermore, skin sensitivity towards capsaicin, a natural activator of TRPV1, was shown to correlate with sensitive skin.	Capsaicin	38-47	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
20626462-6	2010	This antagonist is able to inhibit capsaicin-induced hTRPV1 activation with an IC(50) value of 34 +- 5 mum tested in HEK293-cells as well as in electrophysiological recordings performed in oocytes expressing hTRPV1.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-59
20626462-6	2010	This antagonist is able to inhibit capsaicin-induced hTRPV1 activation with an IC(50) value of 34 +- 5 mum tested in HEK293-cells as well as in electrophysiological recordings performed in oocytes expressing hTRPV1.	Capsaicin	35-44	transient receptor potential cation channel subfamily V member 1	Homo sapiens	208-214
20539001-10	2010	In contrast, high concentrations of 2-APB (3 mM) increased [Ca(2+)](i), whereas the TRPV1 channel opener capsaicin and the TRPV3 channel opener camphor had no effect.	Capsaicin	105-114	transient receptor potential cation channel subfamily V member 1	Homo sapiens	84-89
20414744-1	2010	Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in capsaicin-sensitive sensory neurons and inflammatory/immune cells, therefore it is suggested to play a role in neuro-immune interactions.	Capsaicin	73-82	adenylate cyclase activating polypeptide 1	Mus musculus	0-50
20414744-1	2010	Pituitary adenylate cyclase-activating polypeptide (PACAP) is present in capsaicin-sensitive sensory neurons and inflammatory/immune cells, therefore it is suggested to play a role in neuro-immune interactions.	Capsaicin	73-82	adenylate cyclase activating polypeptide 1	Mus musculus	52-57
20806405-4	2010	Intraductal administration of capsaicin and trypsin caused prompt phosphorylation of ERK in the superficial layers of T9, but not T5 or T12, spinal dorsal horn.	Capsaicin	30-39	Eph receptor B1	Rattus norvegicus	85-88
20739601-4	2010	AITC and/or capsaicin activated the vast majority of histamine- and PAR-2 agonist-sensitive TG cells.	Capsaicin	12-21	pulmonary adenoma resistance 2	Mus musculus	68-73
20832942-10	2010	In contrast, capsaicin-stimulated CGRP release was reduced in sciatic nerves.	Capsaicin	13-22	calcitonin-related polypeptide alpha	Rattus norvegicus	34-38
20884761-6	2010	Bath application of 2AG or the TRPV1 agonists capsaicin and resiniferatoxin mimicked LTD and both capsaicin- and 2AG-induced depression were blocked by capsazepine.	Capsaicin	46-55	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
20884761-6	2010	Bath application of 2AG or the TRPV1 agonists capsaicin and resiniferatoxin mimicked LTD and both capsaicin- and 2AG-induced depression were blocked by capsazepine.	Capsaicin	98-107	transient receptor potential cation channel subfamily V member 1	Homo sapiens	31-36
20599324-8	2010	IL-6-enhanced capsaicin-evoked release of calcitonin gene-related peptide from cultured DRG neurons was blocked by TB-2-081.	Capsaicin	14-23	interleukin 6	Rattus norvegicus	0-4
20980604-10	2010	Such results suggest that activated, presynaptic TRPV1+ receptors trigger continuous resting release of glutamate vesicles at physiological temperatures only in capsaicin-responsive terminals.	Capsaicin	161-170	transient receptor potential cation channel subfamily V member 1	Homo sapiens	49-54
20643195-2	2010	The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia.	Capsaicin	181-190	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	35-38
20643195-2	2010	The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia.	Capsaicin	181-190	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	66-69
20643195-2	2010	The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia.	Capsaicin	181-190	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	204-244
20643195-2	2010	The aim of this study was to use c-fos like immunohistochemistry (Fos-LI) to map the trigeminal brainstem complex after intravitreal microinjection or ocular surface application of capsaicin, a selective transient receptor potential vanilloid 1 (TRPV1) agonist in male rats under barbiturate anesthesia.	Capsaicin	181-190	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	246-251
20643195-4	2010	In non-inflamed controls, intravitreal capsaicin produced peaks of Fos-LI at the trigeminal subnucleus interpolaris/caudalis (Vi/Vcvl) transition and in superficial laminae at the caudalis/upper cervical cord (Vc/C1) junction regions.	Capsaicin	39-48	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	67-70
20643195-5	2010	At the Vc/C1 junction intravitreal capsaicin induced Fos-LI in a dose-dependent manner, while at the Vi/Vcvl transition responses were similar after vehicle or capsaicin injections.	Capsaicin	35-44	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	53-56
20643195-6	2010	Two days, but not 7 days, after UV irradiation intravitreal and ocular surface capsaicin-evoked Fos-LI at the Vc/C1 junction and nucleus tractus solitarius (NTS) were markedly enhanced, whereas the responses at the Vi/Vcvl transition were not different from non-inflamed controls.	Capsaicin	79-88	Fos proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	96-99
20643195-9	2010	The similar pattern and magnitude of Fos-LI after capsaicin suggested that TRPV1-responsive trigeminal nerves that supply intraocular and ocular surface tissues form a unified integrative circuit in the caudal brainstem.	Capsaicin	50-59	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	75-80
19168246-2	2010	The potent vasodilator calcitonin gene-related peptide (CGRP) is stored in a population of C-fiber afferents that are sensitive to capsaicin.	Capsaicin	131-140	Calcitonin gene-related peptide	Sus scrofa	56-60
19168246-5	2010	Furthermore, it has also been reported that capsaicin-treated pigs have significantly increased mean arterial blood pressure compared with controls, and that the decrease in CGRP synthesis and release contributes to the elevated blood pressure.	Capsaicin	44-53	Calcitonin gene-related peptide	Sus scrofa	174-178
20639352-5	2010	1) A pretreatment with TNFalpha (50 ng/ml) for ~24 h increased significantly the peak Delta[Ca(2+)](i) evoked by capsaicin (Cap) in these neurons.	Capsaicin	113-122	tumor necrosis factor	Rattus norvegicus	23-31
20937102-1	2010	Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed endovanilloids.	Capsaicin	123-132	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-45
20937102-1	2010	Transient receptor potential vanilloid type 1 (TRPV1) receptor is a non selective ligand-gated cation channel activated by capsaicin, heat, protons and endogenous lipids termed endovanilloids.	Capsaicin	123-132	transient receptor potential cation channel subfamily V member 1	Homo sapiens	47-52
20639352-5	2010	1) A pretreatment with TNFalpha (50 ng/ml) for ~24 h increased significantly the peak Delta[Ca(2+)](i) evoked by capsaicin (Cap) in these neurons.	Capsaicin	124-127	tumor necrosis factor	Rattus norvegicus	23-31
20808213-10	2010	Moreover, the capsaicin-induced desensitization of TRPV1 was markedly attenuated in the presence of propofol in neurons from wild-type mice but not in neurons from PKCepsilon-null mice.	Capsaicin	14-23	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	51-56
20808213-13	2010	DISCUSSION: Our results indicate that propofol modulates TRPV1 sensitivity to capsaicin and that this most likely occurs through a PKCepsilon-mediated phosphorylation of TRPV1.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	57-62
20808213-13	2010	DISCUSSION: Our results indicate that propofol modulates TRPV1 sensitivity to capsaicin and that this most likely occurs through a PKCepsilon-mediated phosphorylation of TRPV1.	Capsaicin	78-87	protein kinase C, epsilon	Mus musculus	131-141
20808213-13	2010	DISCUSSION: Our results indicate that propofol modulates TRPV1 sensitivity to capsaicin and that this most likely occurs through a PKCepsilon-mediated phosphorylation of TRPV1.	Capsaicin	78-87	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	170-175
21103419-4	2010	Epithelial cells contain TRPV1 receptor mRNA and protein and respond to HCl and to the TRPV1 agonist capsaicin with production of PAF.	Capsaicin	101-110	transient receptor potential cation channel subfamily V member 1	Homo sapiens	87-92
21156013-7	2010	TRPV1 is co-expressed with TRPA1, and TRPA1 is known to be present on capsaicin-sensitive primary sensory neurones.	Capsaicin	70-79	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-5
21156013-7	2010	TRPV1 is co-expressed with TRPA1, and TRPA1 is known to be present on capsaicin-sensitive primary sensory neurones.	Capsaicin	70-79	transient receptor potential cation channel subfamily A member 1	Homo sapiens	38-43
20962894-8	2010	The beneficial effects of rutaecarpine were attenuated by pretreatment with capsaicin, which selectively depleted CGRP.	Capsaicin	76-85	calcitonin-related polypeptide alpha	Rattus norvegicus	114-118
20678598-3	2010	It has been shown that GRb1 and PF inhibited the productions of IL-8 and PGE2 induced by capsaicin (CAP) in HaCaT cells and HEK 293T-TRPV1 cells (which were transgenic and overexpressed TRPV1) but had no effect on HEK 293T mock cells (p&lt;0.05).	Capsaicin	89-98	C-X-C motif chemokine ligand 8	Homo sapiens	64-68
21103419-4	2010	Epithelial cells contain TRPV1 receptor mRNA and protein and respond to HCl and to the TRPV1 agonist capsaicin with production of PAF.	Capsaicin	101-110	PCNA clamp associated factor	Homo sapiens	130-133
20693293-5	2010	The changes in open and closed state time constants following activation of PKC are equivalent to an increased affinity of capsaicin binding, but other arguments suggest that channel opening must be potentiated by downstream changes in channel activation rather than by a direct action of phosphorylation on the capsaicin binding site.	Capsaicin	123-132	proline rich transmembrane protein 2	Homo sapiens	76-79
20693293-5	2010	The changes in open and closed state time constants following activation of PKC are equivalent to an increased affinity of capsaicin binding, but other arguments suggest that channel opening must be potentiated by downstream changes in channel activation rather than by a direct action of phosphorylation on the capsaicin binding site.	Capsaicin	312-321	proline rich transmembrane protein 2	Homo sapiens	76-79
21169106-2	2010	Stimulation of TRPV1 receptors with capsaicin may induce heartburn.	Capsaicin	36-45	transient receptor potential cation channel subfamily V member 1	Homo sapiens	15-20
21081795-11	2010	Above stimulatory effects of investigated substances on CCK release were completely abolished by bilateral, subdiaphragmatic vagotomy, capsaicin-deactivation of afferent nerves as well as blockade of CCK receptors.	Capsaicin	135-144	cholecystokinin	Rattus norvegicus	56-59
21169106-3	2010	Capsaicin is the pungent component of chili and the most extensively studied TRPV1 agonist.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
20856883-7	2010	Finally we tested by a paired preference paradigm their aversion to oral administration of capsaicin, which activates the noxious heat receptor TRPV1.	Capsaicin	91-100	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	144-149
20639579-7	2010	Functional analysis of TRPV1-I585V, using the Ca(2+)-sensitive dye fura-2 to measure intracellular [Ca(2+)] concentrations, revealed a decreased channel activity in response to two typical TRPV1 stimuli, heat and capsaicin.	Capsaicin	213-222	transient receptor potential cation channel subfamily V member 1	Homo sapiens	23-28
20639579-7	2010	Functional analysis of TRPV1-I585V, using the Ca(2+)-sensitive dye fura-2 to measure intracellular [Ca(2+)] concentrations, revealed a decreased channel activity in response to two typical TRPV1 stimuli, heat and capsaicin.	Capsaicin	213-222	transient receptor potential cation channel subfamily V member 1	Homo sapiens	189-194
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Capsaicin	48-57	epidermal growth factor receptor	Mus musculus	14-18
20331538-3	2010	Therefore, this study was undertaken to delineate the actions of PBG on respiration and compared with those evoked by capsaicin (TRPV1 agonist).	Capsaicin	118-127	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	129-134
20539005-5	2010	Agonists of TRPV4 and TRPA1 increased intracellular Ca(2+) concentration ([Ca(2+)](i)) in these neurons in culture, and neurons also responded to the TRPV1 agonist capsaicin and are thus nociceptors.	Capsaicin	164-173	transient receptor potential cation channel, subfamily V, member 4	Mus musculus	12-17
20539005-5	2010	Agonists of TRPV4 and TRPA1 increased intracellular Ca(2+) concentration ([Ca(2+)](i)) in these neurons in culture, and neurons also responded to the TRPV1 agonist capsaicin and are thus nociceptors.	Capsaicin	164-173	transient receptor potential cation channel, subfamily A, member 1	Mus musculus	22-27
20539005-5	2010	Agonists of TRPV4 and TRPA1 increased intracellular Ca(2+) concentration ([Ca(2+)](i)) in these neurons in culture, and neurons also responded to the TRPV1 agonist capsaicin and are thus nociceptors.	Capsaicin	164-173	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	150-155
20660715-0	2010	Cocarcinogenic effect of capsaicin involves activation of EGFR signaling but not TRPV1.	Capsaicin	25-34	epidermal growth factor receptor	Mus musculus	58-62
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Capsaicin	21-30	epidermal growth factor receptor	Mus musculus	170-202
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Capsaicin	21-30	epidermal growth factor receptor	Mus musculus	204-208
20660715-3	2010	Here, we report that capsaicin has a cocarcinogenic effect on 12-O-tetradecanoylphorbol-13-acetate (TPA)-promoted skin carcinogenesis in vivo and is mediated through the epidermal growth factor receptor (EGFR), but not the transient receptor potential vanilloid subfamily member 1 (TRPV1).	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	282-287
20660715-4	2010	Topical application of capsaicin on the dorsal skin of 7,12-dimetylbenz(a)anthracene-initiated and TPA-promoted TRPV1 wild-type (WT) and TRPV1 knockout (KO) mice induced more and larger skin tumors in TRPV1/KO mice, suggesting a TRPV1-independent mechanism.	Capsaicin	23-32	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	112-117
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Capsaicin	48-57	prostaglandin-endoperoxide synthase 2	Mus musculus	66-71
20660715-5	2010	Cyclooxygenase-2 (COX-2) was highly elevated by capsaicin treatment in tumors and murine embryonic fibroblasts from TRPV1/KO mice.	Capsaicin	48-57	prostaglandin-endoperoxide synthase 2	Mus musculus	0-16
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	86-91
20660715-5	2010	Cyclooxygenase-2 (COX-2) was highly elevated by capsaicin treatment in tumors and murine embryonic fibroblasts from TRPV1/KO mice.	Capsaicin	48-57	prostaglandin-endoperoxide synthase 2	Mus musculus	18-23
20660715-5	2010	Cyclooxygenase-2 (COX-2) was highly elevated by capsaicin treatment in tumors and murine embryonic fibroblasts from TRPV1/KO mice.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	116-121
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Capsaicin	48-57	epidermal growth factor receptor	Mus musculus	132-136
20660715-6	2010	Inhibitors of EGFR/MEK signaling suppressed TPA/capsaicin-induced COX-2 expression in TRPV1/KO cells, indicating that activation of EGFR and its downstream signaling is involved in COX-2 elevation.	Capsaicin	48-57	prostaglandin-endoperoxide synthase 2	Mus musculus	181-186
20660715-7	2010	Capsaicin induced a further induction of TPA-increased COX-2 expression in EGFR/WT cells, but not in EGFR/KO cells.	Capsaicin	0-9	prostaglandin-endoperoxide synthase 2	Mus musculus	55-60
20660715-7	2010	Capsaicin induced a further induction of TPA-increased COX-2 expression in EGFR/WT cells, but not in EGFR/KO cells.	Capsaicin	0-9	epidermal growth factor receptor	Mus musculus	75-79
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Capsaicin	4-13	epidermal growth factor receptor	Mus musculus	33-37
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Capsaicin	4-13	epidermal growth factor receptor	Mus musculus	77-81
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Capsaicin	4-13	thymoma viral proto-oncogene 1	Mus musculus	123-126
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Capsaicin	4-13	epidermal growth factor receptor	Mus musculus	77-81
20660715-8	2010	TPA/capsaicin cotreatment caused EGFR tyrosine phosphorylation and activated EGFR downstream signaling, including ERKs and Akt in EGFR/WT, but not EGFR/KO cells.	Capsaicin	4-13	epidermal growth factor receptor	Mus musculus	77-81
20660715-9	2010	Specific inhibition of EGFR and TRPV1 indicated that capsaicin-induced ERK activation in A431 cells was dependent on EGFR, but not TRPV1.	Capsaicin	53-62	epidermal growth factor receptor	Mus musculus	23-27
20660715-9	2010	Specific inhibition of EGFR and TRPV1 indicated that capsaicin-induced ERK activation in A431 cells was dependent on EGFR, but not TRPV1.	Capsaicin	53-62	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	32-37
20660715-9	2010	Specific inhibition of EGFR and TRPV1 indicated that capsaicin-induced ERK activation in A431 cells was dependent on EGFR, but not TRPV1.	Capsaicin	53-62	epidermal growth factor receptor	Mus musculus	117-121
20660715-10	2010	Together, these findings suggest that capsaicin might act as a cocarcinogen in TPA-induced skin carcinogenesis through EGFR-dependent mechanisms.	Capsaicin	38-47	epidermal growth factor receptor	Mus musculus	119-123
20576527-2	2010	In vivo activation of TRPV1 receptors by natural agonists like capsaicin is associated with a sharp and burning pain, frequently described as pungency.	Capsaicin	63-72	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	22-27
20538089-10	2010	Capsaicin, an agonist activator of the vanilloid nociceptors (TRPV1), appears to be effective in protecting bone from arthritic damage.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	62-67
20016958-7	2010	Results support the idea that capsaicin may interact with the transduction pathways of sweet and bitter taste stimuli, possibly in mediation of its receptor VR1 localized in taste receptor cells.	Capsaicin	30-39	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	157-160
20619260-3	2010	Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.	Capsaicin	71-80	cannabinoid receptor 1	Homo sapiens	19-22
20619260-3	2010	Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
20619260-3	2010	Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.	Capsaicin	71-80	epidermal growth factor receptor	Homo sapiens	110-114
20619260-3	2010	Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.	Capsaicin	82-85	cannabinoid receptor 1	Homo sapiens	19-22
20619260-3	2010	Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.	Capsaicin	82-85	transient receptor potential cation channel subfamily V member 1	Homo sapiens	27-32
20619260-3	2010	Both the selective CB1 and TRPV1 agonists (i.e., WIN55,212-2 [WIN] and capsaicin [CAP], respectively) induced EGFR phosphorylation whereas either inhibition of its tyrosine kinase activity with AG1478 or functional blockage eliminated this response.	Capsaicin	82-85	epidermal growth factor receptor	Homo sapiens	110-114
20586701-1	2010	IMPORTANCE OF THE FIELD: Transient receptor potential vanilloid-1 (TRPV1, vanilloid receptor-1) is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by capsaicin, the active ingredient in chili peppers.	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-65
20586701-1	2010	IMPORTANCE OF THE FIELD: Transient receptor potential vanilloid-1 (TRPV1, vanilloid receptor-1) is a nonspecific cation channel that can be activated by multiple endogenous stimuli and by capsaicin, the active ingredient in chili peppers.	Capsaicin	188-197	transient receptor potential cation channel subfamily V member 1	Homo sapiens	67-72
20593356-9	2010	Na(v)1.8 immunoreactivity and mRNA expression dropped to approximately 50% of control at 3 days post capsaicin but completely recovered by 60 days.	Capsaicin	101-110	sodium voltage-gated channel alpha subunit 10	Rattus norvegicus	0-8
20492438-4	2010	(ii) somatosensory manipulations of the tongue tip reduced the gains in overall motor performance, and this reduced motor performance was mainly characterized by exaggerated undershoot errors and delayed reaction times for the lidocaine tongue-task training regime and exaggerated overshoot and undershoot errors as well as delayed reaction times for the capsaicin tongue-task training regime.	Capsaicin	355-364	TOR signaling pathway regulator	Homo sapiens	47-50
20680358-6	2010	Third, capsaicin injections (physical stress) into a hind limb of the rat increased junD mRNA expression with no effect on c-fos mRNA expression, and repeated methamphetamine injections had no effect on the capsaicin-induced expression of junD mRNA.	Capsaicin	7-16	JunD proto-oncogene, AP-1 transcription factor subunit	Rattus norvegicus	84-88
20416378-25	2010	Our data suggest that 2-AG, the putative product of MGL inhibition, and AEA, the putative product of FAAH inhibition, differentially suppress capsaicin-induced nociception through peripheral cannabinoid mechanisms.	Capsaicin	142-151	fatty-acid amide hydrolase-like	Rattus norvegicus	101-105
20696045-0	2010	Role of COX-2 in cough reflex sensitivity to inhaled capsaicin in patients with sinobronchial syndrome.	Capsaicin	53-62	mitochondrially encoded cytochrome c oxidase II	Homo sapiens	8-13
20416378-0	2010	Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.	Capsaicin	120-129	monoglyceride lipase	Rattus norvegicus	14-37
20416378-0	2010	Inhibitors of monoacylglycerol lipase, fatty-acid amide hydrolase and endocannabinoid transport differentially suppress capsaicin-induced behavioral sensitization through peripheral endocannabinoid mechanisms.	Capsaicin	120-129	fatty-acid amide hydrolase-like	Rattus norvegicus	39-65
20580681-0	2010	Intranasal TRPV1 agonist capsaicin challenge and its effect on c-fos expression in the guinea pig brainstem.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Cavia porcellus	11-16
20580681-7	2010	In capsaicin group the FLI was detected in the nTs 0.5 mm caudal, 1.5 mm lateral to the obex, the area postrema, LRN and VRG.	Capsaicin	3-12	neurotensin/neuromedin N	Cavia porcellus	47-50
20796308-8	2010	A population of dorsal horn neurons with capsaicin sensitive primary afferent input recorded after the TNFalpha pretreatment had a basal mEPSC frequency of 1.35 +/- 0.20 Hz (n = 13), which was significantly higher when compared to a similar population of neurons in control slices (0.76 +/- 0.08 Hz; n = 53; P &lt; 0.01).	Capsaicin	41-50	tumor necrosis factor	Homo sapiens	103-111
20727164-1	2010	Menthol-sensitive/capsaicin-insensitive neurons (MS/CI) and menthol-sensitive/capsaicin-sensitive neurons (MS/CS) are thought to represent two functionally distinct populations of cold-sensing neurons that use TRPM8 receptors to convey innocuous and noxious cold information respectively.	Capsaicin	78-87	transient receptor potential cation channel, subfamily M, member 8	Rattus norvegicus	210-215
20681644-7	2010	Oral administration of capsaicin with beta-carotene, both at 5 mg/kg/day for 7 days, increased IFN-gamma and IL-2 production in cultured PP cells costimulated with Con A.	Capsaicin	23-32	interferon gamma	Mus musculus	95-104
20681644-7	2010	Oral administration of capsaicin with beta-carotene, both at 5 mg/kg/day for 7 days, increased IFN-gamma and IL-2 production in cultured PP cells costimulated with Con A.	Capsaicin	23-32	interleukin 2	Mus musculus	109-113
20566388-4	2010	Intraplantar capsaicin, a TRPV1 channel agonist, was used to induce neurogenic inflammation in anesthetized rats that were pretreated intrathecally (i.t.	Capsaicin	13-22	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	26-31
20674858-0	2010	Activation of TRPV1 by dietary capsaicin improves endothelium-dependent vasorelaxation and prevents hypertension.	Capsaicin	31-40	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	14-19
20674858-4	2010	Here we report that chronic TRPV1 activation by dietary capsaicin increases the phosphorylation of protein kinase A (PKA) and eNOS and thus production of nitric oxide (NO) in endothelial cells, which is calcium dependent.	Capsaicin	56-65	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	28-33
20674858-5	2010	TRPV1 activation by capsaicin enhances endothelium-dependent relaxation in wild-type mice, an effect absent in TRPV1-deficient mice.	Capsaicin	20-29	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	0-5
20674858-7	2010	We conclude that TRPV1 activation by dietary capsaicin improves endothelial function.	Capsaicin	45-54	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	17-22
20615696-1	2010	The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a non-selective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat.	Capsaicin	181-190	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-70
20615696-1	2010	The transient receptor potential cation channel, subfamily V, member 1 (TRPV1) is a non-selective cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat.	Capsaicin	181-190	transient receptor potential cation channel subfamily V member 1	Homo sapiens	72-77
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	51-60	tripartite motif containing 33	Homo sapiens	14-18
20728216-7	2010	Subpopulations of cells that exhibited the hypercapnic acidosis-induced Ca(2+) response also responded to the application of capsaicin (TRPV1 agonist) and menthol (TRPM8 agonist).	Capsaicin	125-134	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	136-141
20439439-4	2010	In double-chamber baths, capsaicin-evoked activation of TRPV1 on proximal perivascular nerves in the left chamber evoked dilations of the distal segment of the submucosal arteriole in the right chamber.	Capsaicin	25-34	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	56-61
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	51-60	NADPH oxidase 1	Homo sapiens	19-23
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	51-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	176-224
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	51-60	transient receptor potential cation channel subfamily V member 1	Homo sapiens	226-231
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	138-147	tripartite motif containing 33	Homo sapiens	14-18
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	138-147	NADPH oxidase 1	Homo sapiens	19-23
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	138-147	transient receptor potential cation channel subfamily V member 1	Homo sapiens	176-224
20462348-4	2010	We found that Ecto-NOX1 expression is modulated by capsaicin: Indeed, it is positively regulated through a mechanism requiring binding of capsaicin to its receptor, namely the transient receptor potential vanilloid subtype 1 (TRPV1).	Capsaicin	138-147	transient receptor potential cation channel subfamily V member 1	Homo sapiens	226-231
20605331-3	2010	In wild-type mice, hindpaw injections of capsaicin, formalin, mustard oil or menthol induce expression of ATF3 in distinct subpopulations of sensory neurons.	Capsaicin	41-50	activating transcription factor 3	Mus musculus	106-110
20303589-2	2010	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release SP from their central and peripheral axons, suggesting a functional link between SP and the capsaicin receptor, the transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	0-9	tachykinin 1	Mus musculus	69-71
20303589-2	2010	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release SP from their central and peripheral axons, suggesting a functional link between SP and the capsaicin receptor, the transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	0-9	tachykinin 1	Mus musculus	150-152
20303589-2	2010	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release SP from their central and peripheral axons, suggesting a functional link between SP and the capsaicin receptor, the transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	161-179
20303589-2	2010	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release SP from their central and peripheral axons, suggesting a functional link between SP and the capsaicin receptor, the transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	185-225
20303589-2	2010	Capsaicin causes neurons in the dorsal root ganglia (DRG) to release SP from their central and peripheral axons, suggesting a functional link between SP and the capsaicin receptor, the transient receptor potential vanilloid 1 (TRPV1).	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	227-232
20621685-4	2010	In vitro studies showed that capsaicin-evoked TRPV1-dependent CGRP release was 54.7+/-7.7% higher in OA, relative to levels measured for naive rats, suggesting that TRPV1 activity was higher under OA conditions.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	46-51
20621685-4	2010	In vitro studies showed that capsaicin-evoked TRPV1-dependent CGRP release was 54.7+/-7.7% higher in OA, relative to levels measured for naive rats, suggesting that TRPV1 activity was higher under OA conditions.	Capsaicin	29-38	calcitonin-related polypeptide alpha	Rattus norvegicus	62-66
20621685-4	2010	In vitro studies showed that capsaicin-evoked TRPV1-dependent CGRP release was 54.7+/-7.7% higher in OA, relative to levels measured for naive rats, suggesting that TRPV1 activity was higher under OA conditions.	Capsaicin	29-38	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	165-170
20939441-3	2010	Capsaicin is a natural chilli pepper extract that depletes sensory nerve endings of substance P, a pain neurotransmitter.	Capsaicin	0-9	tachykinin precursor 1	Homo sapiens	84-95
20360133-2	2010	Endogenous transient receptor potential vanilloid subtype 1 (TRPV1) has been recently demonstrated in rabbit submandibular glands, and activation of TRPV1 by capsaicin increases secretion in isolated glands, but the TRPV1-mediated secretory mechanism remains to be elucidated.	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	149-154
20561904-3	2010	MAIN METHODS: We used a behavioral rat model of capsaicin-induced trigeminal thermal hyperalgesia, intranasal CO2 application and several pharmacologic agents such as carbonic anhydrase, acid-sensing ion channels (ASICs), and TRPV1 blocker as well as acidic buffer solutions to investigate and mimic the underlying mechanism.	Capsaicin	48-57	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	226-231
20360133-2	2010	Endogenous transient receptor potential vanilloid subtype 1 (TRPV1) has been recently demonstrated in rabbit submandibular glands, and activation of TRPV1 by capsaicin increases secretion in isolated glands, but the TRPV1-mediated secretory mechanism remains to be elucidated.	Capsaicin	158-167	transient receptor potential cation channel subfamily V member 1	Oryctolagus cuniculus	149-154
20360133-3	2010	The purpose of this study was to verify whether activation of TRPV1 by capsaicin could improve the secretion of transplanted gland and its underlying mechanism.	Capsaicin	71-80	transient receptor potential cation channel subfamily V member 1	Homo sapiens	62-67
20360133-5	2010	Topical capsaicin cream increased secretion and upregulated levels of TRPV1 and AQP5 in transplanted glands.	Capsaicin	8-17	transient receptor potential cation channel subfamily V member 1	Homo sapiens	70-75
20360133-5	2010	Topical capsaicin cream increased secretion and upregulated levels of TRPV1 and AQP5 in transplanted glands.	Capsaicin	8-17	aquaporin 5	Homo sapiens	80-84
20360133-6	2010	Moreover, in cultured submandibular gland cells, capsaicin increased the mRNA expression of AQP5 and led to redistribution of AQP5 from the cytoplasm to the plasma membrane via TRPV1 activation.	Capsaicin	49-58	aquaporin 5	Homo sapiens	92-96
20360133-6	2010	Moreover, in cultured submandibular gland cells, capsaicin increased the mRNA expression of AQP5 and led to redistribution of AQP5 from the cytoplasm to the plasma membrane via TRPV1 activation.	Capsaicin	49-58	aquaporin 5	Homo sapiens	126-130
20360133-6	2010	Moreover, in cultured submandibular gland cells, capsaicin increased the mRNA expression of AQP5 and led to redistribution of AQP5 from the cytoplasm to the plasma membrane via TRPV1 activation.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	177-182
20360133-7	2010	Capsaicin enhanced the phosphorylation of extracellular signal-regulated kinase (ERK).	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	42-79
20360133-7	2010	Capsaicin enhanced the phosphorylation of extracellular signal-regulated kinase (ERK).	Capsaicin	0-9	mitogen-activated protein kinase 1	Homo sapiens	81-84
20360133-8	2010	Preincubation of cells with PD98059, an inhibitor of ERK kinase, suppressed the capsaicin-induced mRNA expression of AQP5.	Capsaicin	80-89	mitogen-activated protein kinase 1	Homo sapiens	53-56
20360133-8	2010	Preincubation of cells with PD98059, an inhibitor of ERK kinase, suppressed the capsaicin-induced mRNA expression of AQP5.	Capsaicin	80-89	aquaporin 5	Homo sapiens	117-121
20360133-9	2010	In summary, the capsaicin-induced secretory mechanism involved activation of TRPV1 and upregulation of AQP5 in an ERK-dependent manner and promoted the redistribution of AQP5 in submandibular gland cells.	Capsaicin	16-25	transient receptor potential cation channel subfamily V member 1	Homo sapiens	77-82
20360133-9	2010	In summary, the capsaicin-induced secretory mechanism involved activation of TRPV1 and upregulation of AQP5 in an ERK-dependent manner and promoted the redistribution of AQP5 in submandibular gland cells.	Capsaicin	16-25	aquaporin 5	Homo sapiens	103-107
20360133-9	2010	In summary, the capsaicin-induced secretory mechanism involved activation of TRPV1 and upregulation of AQP5 in an ERK-dependent manner and promoted the redistribution of AQP5 in submandibular gland cells.	Capsaicin	16-25	mitogen-activated protein kinase 1	Homo sapiens	114-117
20360133-9	2010	In summary, the capsaicin-induced secretory mechanism involved activation of TRPV1 and upregulation of AQP5 in an ERK-dependent manner and promoted the redistribution of AQP5 in submandibular gland cells.	Capsaicin	16-25	aquaporin 5	Homo sapiens	170-174
20123014-1	2010	Capsaicin, the hot chemical in chillies, administered to neonatal rats, causes destruction of polymodal nociceptive primary afferent neurons by acting on TRPV1 receptors causing intrinsic somatosensory deprivation.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	154-159
20123014-3	2010	In the present study the effect of neonatal capsaicin treatment on brain receptors that have been shown to interact with TRPV1 was examined.	Capsaicin	44-53	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	121-126
20371865-6	2010	Capsaicin, an agonist of VR1, increased intracellular free calcium, enhanced phosphorylation of extracellular signal-regulated kinase, and induced the trafficking of aquaporin 5 (AQP5) from the cytoplasm to the plasma membrane.	Capsaicin	0-9	transient receptor potential cation channel subfamily V member 1	Homo sapiens	25-28
20371669-0	2010	Autophagy induction by capsaicin in malignant human breast cells is modulated by p38 and extracellular signal-regulated mitogen-activated protein kinases and retards cell death by suppressing endoplasmic reticulum stress-mediated apoptosis.	Capsaicin	23-32	mitogen-activated protein kinase 14	Homo sapiens	81-84
20371865-6	2010	Capsaicin, an agonist of VR1, increased intracellular free calcium, enhanced phosphorylation of extracellular signal-regulated kinase, and induced the trafficking of aquaporin 5 (AQP5) from the cytoplasm to the plasma membrane.	Capsaicin	0-9	aquaporin 5	Homo sapiens	166-177
20371865-6	2010	Capsaicin, an agonist of VR1, increased intracellular free calcium, enhanced phosphorylation of extracellular signal-regulated kinase, and induced the trafficking of aquaporin 5 (AQP5) from the cytoplasm to the plasma membrane.	Capsaicin	0-9	aquaporin 5	Homo sapiens	179-183
20371669-4	2010	In MCF-7 and MDA-MB-231 cells, capsaicin induced endoplasmic reticulum (ER) stress via inositol-requiring 1 and Chop and induced autophagy, as demonstrated by microtubule-associated protein 1 light chain-3 (LC3) conversion.	Capsaicin	31-40	endoplasmic reticulum to nucleus signaling 1	Homo sapiens	87-107
20371669-4	2010	In MCF-7 and MDA-MB-231 cells, capsaicin induced endoplasmic reticulum (ER) stress via inositol-requiring 1 and Chop and induced autophagy, as demonstrated by microtubule-associated protein 1 light chain-3 (LC3) conversion.	Capsaicin	31-40	DNA damage inducible transcript 3	Homo sapiens	112-116
20371669-4	2010	In MCF-7 and MDA-MB-231 cells, capsaicin induced endoplasmic reticulum (ER) stress via inositol-requiring 1 and Chop and induced autophagy, as demonstrated by microtubule-associated protein 1 light chain-3 (LC3) conversion.	Capsaicin	31-40	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	207-210
20371669-6	2010	In MCF-7 and MDA-MB-231 cells, p38 was activated for more than 48 h by capsaicin treatment, but extracellular signal-regulated kinase (ERK) activation decreased after 12 h, and LC3II levels continuously increased.	Capsaicin	71-80	mitogen-activated protein kinase 14	Homo sapiens	31-34
20371669-7	2010	Furthermore, treatment with 3MA markedly down-regulated capsaicin-induced p38 activation and LC3 conversion, and BaF1 completely down-regulated ERK activation and led to LC3II accumulation.	Capsaicin	56-65	mitogen-activated protein kinase 14	Homo sapiens	74-77
20371669-7	2010	Furthermore, treatment with 3MA markedly down-regulated capsaicin-induced p38 activation and LC3 conversion, and BaF1 completely down-regulated ERK activation and led to LC3II accumulation.	Capsaicin	56-65	microtubule associated protein 1 light chain 3 alpha	Homo sapiens	93-96
20371669-8	2010	In addition, pharmacological blockade or knockdown of the p38 gene down-regulated Akt activation and LC3II levels but did not affect ERK, and pharmacological blockade or knockdown of the ERK gene up-regulated LC3II induction by capsaicin.	Capsaicin	228-237	mitogen-activated protein kinase 14	Homo sapiens	58-61
20371669-8	2010	In addition, pharmacological blockade or knockdown of the p38 gene down-regulated Akt activation and LC3II levels but did not affect ERK, and pharmacological blockade or knockdown of the ERK gene up-regulated LC3II induction by capsaicin.	Capsaicin	228-237	mitogen-activated protein kinase 1	Homo sapiens	187-190
20371669-10	2010	In MCF10A cells, capsaicin did not elicit p38 activation and LC3 conversion and caused the sustained activation of caspase-4.	Capsaicin	17-26	caspase 4	Homo sapiens	115-124
20371669-11	2010	Collectively, capsaicin-induced autophagy is regulated by p38 and ERK; p38 controls autophagy at the sequestration step, whereas ERK controls autophagy at the maturation step, and that autophagy is involved in the retardation of cell death by blocking capsaicin-induced ER stress-mediated apoptosis in MCF-7 and MDA-MB-321 cells.	Capsaicin	14-23	mitogen-activated protein kinase 14	Homo sapiens	58-61
20371669-11	2010	Collectively, capsaicin-induced autophagy is regulated by p38 and ERK; p38 controls autophagy at the sequestration step, whereas ERK controls autophagy at the maturation step, and that autophagy is involved in the retardation of cell death by blocking capsaicin-induced ER stress-mediated apoptosis in MCF-7 and MDA-MB-321 cells.	Capsaicin	14-23	mitogen-activated protein kinase 1	Homo sapiens	66-69
20371669-11	2010	Collectively, capsaicin-induced autophagy is regulated by p38 and ERK; p38 controls autophagy at the sequestration step, whereas ERK controls autophagy at the maturation step, and that autophagy is involved in the retardation of cell death by blocking capsaicin-induced ER stress-mediated apoptosis in MCF-7 and MDA-MB-321 cells.	Capsaicin	14-23	mitogen-activated protein kinase 14	Homo sapiens	71-74
20371669-11	2010	Collectively, capsaicin-induced autophagy is regulated by p38 and ERK; p38 controls autophagy at the sequestration step, whereas ERK controls autophagy at the maturation step, and that autophagy is involved in the retardation of cell death by blocking capsaicin-induced ER stress-mediated apoptosis in MCF-7 and MDA-MB-321 cells.	Capsaicin	14-23	mitogen-activated protein kinase 1	Homo sapiens	129-132
20451324-3	2010	We studied the effects of 2microM capsaicin-induced TRPV1 activation in organotypically cultured substantia gelatinosa neurons from post-natal (8-12) mice.	Capsaicin	34-43	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	52-57
20236764-4	2010	However, co-application of QX-314 and capsaicin blocked I(Na) and APs in TRPV1-positive TG and dental nociceptive neurons, but not in TRPV1-negative TG neurons or in small neurons from TRPV1 knock-out mice.	Capsaicin	38-47	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	73-78
20451324-6	2010	Pre-administration of I-RTX (1microM), a TRPV1 antagonist, prevented the capsaicin effect (frequency: 149+/-28% of control, P&gt;0.05, n=12; amplitude: 97+/-4% of control, P&gt;0.05, n=12).	Capsaicin	73-82	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	41-46
20359164-7	2010	Most of the identified proteins are associated with lipid metabolism and redox regulation, in which levels of vimentin, peroxiredoxin, and NAD(P)H:quinone oxidoreductase 1 (NQO1) were significantly reduced (&gt;2-fold), whereas aldo-keto reductase, flavoprotein increased with capsaicin treatment.	Capsaicin	277-286	vimentin	Rattus norvegicus	110-118
20427129-0	2010	Inhibition of glucosylceramide synthase reversibly decreases the capsaicin-induced activation and TRPV1 expression of cultured dorsal root ganglion neurons.	Capsaicin	65-74	UDP-glucose ceramide glucosyltransferase	Rattus norvegicus	14-39
20427129-3	2010	In control cultures, capsaicin resulted in the activation of TRPV1 in 29.7+/-2.5% of the neurons, as assessed with the cobalt uptake assay.	Capsaicin	21-30	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	61-66
20197082-2	2010	Systemic capsaicin treatment destroys gastric vagal afferent neurons expressing vanilloid receptor 1 (VR1).	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	80-100
20359164-7	2010	Most of the identified proteins are associated with lipid metabolism and redox regulation, in which levels of vimentin, peroxiredoxin, and NAD(P)H:quinone oxidoreductase 1 (NQO1) were significantly reduced (&gt;2-fold), whereas aldo-keto reductase, flavoprotein increased with capsaicin treatment.	Capsaicin	277-286	NAD(P)H quinone dehydrogenase 1	Rattus norvegicus	173-177
20197082-2	2010	Systemic capsaicin treatment destroys gastric vagal afferent neurons expressing vanilloid receptor 1 (VR1).	Capsaicin	9-18	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	102-105
20197082-6	2010	The numbers of VR1-immunoreactive neurons projecting to the stomach were significantly reduced 10 days after either capsaicin treatment or vagotomy.	Capsaicin	116-125	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	15-18
20197082-7	2010	However, the VR1-immunoreactive afferent innervation of the stomach was restored to levels exceeding those of vagotomized rats by 37 days after capsaicin, whereas neither total afferent innervation nor VR1-immunoreactive innervation reached control levels, even by 67 days after vagotomy.	Capsaicin	144-153	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	13-16
20197082-8	2010	Capsaicin treatment significantly increased NG neuronal nitric oxide synthase (nNOS) immunoreactivity at 10 days after capsaicin, and this increase was sustained for the duration of the study, indicating higher nNOS demand in restoration of vagal projections.	Capsaicin	0-9	nitric oxide synthase 1	Rattus norvegicus	47-77
20197082-8	2010	Capsaicin treatment significantly increased NG neuronal nitric oxide synthase (nNOS) immunoreactivity at 10 days after capsaicin, and this increase was sustained for the duration of the study, indicating higher nNOS demand in restoration of vagal projections.	Capsaicin	0-9	nitric oxide synthase 1	Rattus norvegicus	79-83
20197082-8	2010	Capsaicin treatment significantly increased NG neuronal nitric oxide synthase (nNOS) immunoreactivity at 10 days after capsaicin, and this increase was sustained for the duration of the study, indicating higher nNOS demand in restoration of vagal projections.	Capsaicin	0-9	nitric oxide synthase 1	Rattus norvegicus	211-215
20197082-8	2010	Capsaicin treatment significantly increased NG neuronal nitric oxide synthase (nNOS) immunoreactivity at 10 days after capsaicin, and this increase was sustained for the duration of the study, indicating higher nNOS demand in restoration of vagal projections.	Capsaicin	119-128	nitric oxide synthase 1	Rattus norvegicus	79-83
20197082-10	2010	The number of nNOS-immunopositive gastric-projecting neurons was dramatically reduced 10 days after either capsaicin treatment or vagotomy but returned to the control level in both groups at 67 days.	Capsaicin	107-116	nitric oxide synthase 1	Rattus norvegicus	14-18
20197082-12	2010	Capsaicin significantly increased the number of nNOS-immunopositive and nNOS-immunonegative growth cones in NG at all time points.	Capsaicin	0-9	nitric oxide synthase 1	Rattus norvegicus	48-52
20197082-12	2010	Capsaicin significantly increased the number of nNOS-immunopositive and nNOS-immunonegative growth cones in NG at all time points.	Capsaicin	0-9	nitric oxide synthase 1	Rattus norvegicus	72-76
20335377-6	2010	Capsaicin was used to activate TRPV1.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	31-36
20335377-11	2010	UTP, a P2Y purinoceptor 2 (P2Y(2))/P2Y(4) receptor agonist, reversed capsaicin-induced TRPV1 desensitization.	Capsaicin	69-78	purinergic receptor P2Y2	Rattus norvegicus	7-25
20335377-11	2010	UTP, a P2Y purinoceptor 2 (P2Y(2))/P2Y(4) receptor agonist, reversed capsaicin-induced TRPV1 desensitization.	Capsaicin	69-78	purinergic receptor P2Y2	Rattus norvegicus	27-33
20335377-11	2010	UTP, a P2Y purinoceptor 2 (P2Y(2))/P2Y(4) receptor agonist, reversed capsaicin-induced TRPV1 desensitization.	Capsaicin	69-78	transient receptor potential cation channel, subfamily V, member 1	Rattus norvegicus	87-92
20144892-5	2010	Capsaicin, a selective TRPV1 agonist had no measurable effect on overall synaptic input to granule cells in control animals, but significantly enhanced spontaneous and miniature EPSC frequency in mice with TLE.	Capsaicin	0-9	transient receptor potential cation channel, subfamily V, member 1	Mus musculus	23-28
20446852-2	2010	IMPORTANCE OF THE FIELD: Capsaicin and its receptor, TRPV1, occupy a central place in current neurophysiological studies regarding pain transmission and have opened new avenues for understanding the role of transient receptor potential (TRP) receptors in itch processing.	Capsaicin	25-34	transient receptor potential cation channel subfamily V member 1	Homo sapiens	53-58
20338165-7	2010	TRPV1-3 functional activity was evident based on capsaicin-induced Ca(2+) transients and induction of these responses through rises in ambient temperature from 25 degrees C to over 40 degrees C. The currents underlying Ca(2+) transients were characterized with a novel high throughput patch-clamp system.	Capsaicin	49-58	transient receptor potential cation channel subfamily V member 1	Homo sapiens	0-7
20338165-8	2010	The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
20338165-8	2010	The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium.	Capsaicin	29-38	transient receptor potential cation channel subfamily V member 1	Homo sapiens	180-185
20338165-8	2010	The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium.	Capsaicin	40-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	4-9
20338165-8	2010	The TRPV1 selective agonist, capsaicin (CAP) (10-20 microM) increased non-selective cation whole-cell currents resulting in calcium increases that were fully blocked by either the TRPV1 antagonist capsazepine (CPZ) or removal of extracellular calcium.	Capsaicin	40-43	transient receptor potential cation channel subfamily V member 1	Homo sapiens	180-185
20179142-5	2010	Functionally, GABARAP expression attenuated voltage and capsaicin sensitivity of TRPV1 in the presence of extracellular calcium.	Capsaicin	56-65	GABA type A receptor-associated protein	Homo sapiens	14-21
20497466-6	2010	Cinnamaldehyde (TRPA1 agonist) elicited a barrage of excitatory postsynaptic currents (EPSCs) in a subset of the SG neurons that responded to allyl isothiocyanate (less specific TRPA1 agonist) and capsaicin (TRPV1 agonist).	Capsaicin	197-206	transient receptor potential cation channel, subfamily A, member 1	Rattus norvegicus	16-21
20179142-6	2010	Furthermore, the presence of the anchor protein GABARAP notably lengthened the kinetics of vanilloid-induced tachyphylaxia.	Capsaicin	91-100	GABA type A receptor-associated protein	Homo sapiens	48-55
20179142-5	2010	Functionally, GABARAP expression attenuated voltage and capsaicin sensitivity of TRPV1 in the presence of extracellular calcium.	Capsaicin	56-65	transient receptor potential cation channel subfamily V member 1	Homo sapiens	81-86
20179142-8	2010	Disruption of tubulin cytoskeleton with nocodazole reduced capsaicin-evoked currents in cells expressing TRPV1 and GABARAP, without affecting the kinetics of vanilloid-induced desensitization.	Capsaicin	59-68	transient receptor potential cation channel subfamily V member 1	Homo sapiens	105-110
20179142-8	2010	Disruption of tubulin cytoskeleton with nocodazole reduced capsaicin-evoked currents in cells expressing TRPV1 and GABARAP, without affecting the kinetics of vanilloid-induced desensitization.	Capsaicin	59-68	GABA type A receptor-associated protein	Homo sapiens	115-122
21932983-0	2011	Capsaicin induces apoptosis of cisplatin-resistant stomach cancer cells by causing degradation of cisplatin-inducible Aurora-A protein.	Capsaicin	0-9	aurora kinase A	Homo sapiens	118-126
21932983-5	2011	Furthermore, we discovered that Aurora-A protein increased in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin, suggesting that the Aurora-A-mediated signaling pathway is responsible for the resistance to cisplatin in cisplatin-resistant gastric cancer cell lines.	Capsaicin	130-139	aurora kinase A	Homo sapiens	32-40
21932983-5	2011	Furthermore, we discovered that Aurora-A protein increased in response to cisplatin and was degraded upon combined treatment with capsaicin with cisplatin, suggesting that the Aurora-A-mediated signaling pathway is responsible for the resistance to cisplatin in cisplatin-resistant gastric cancer cell lines.	Capsaicin	130-139	aurora kinase A	Homo sapiens	176-184
21932983-7	2011	Combined treatment with capsaicin and cisplatin inhibited IkappaB phosphorylation in a dose-dependent manner, suggesting that Aurora-A directly or indirectly regulates NF-kappaB translocation.	Capsaicin	24-33	aurora kinase A	Homo sapiens	126-134