PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 33029124-12 2020 Nonetheless, intrathecal injection of the SK2 channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) in MS mice could reverse the electrophysiological alterations and elevate the visceral pain threshold. 1-ethyl-2-benzimidazolinone 64-91 skin antigen 2 Mus musculus 42-45 33029124-12 2020 Nonetheless, intrathecal injection of the SK2 channel activator 1-ethyl-2-benzimidazolinone (1-EBIO) in MS mice could reverse the electrophysiological alterations and elevate the visceral pain threshold. 1-ethyl-2-benzimidazolinone 93-99 skin antigen 2 Mus musculus 42-45 26807020-6 2016 1-EBIO, an activator of SK4, induced outward K(+) current (ISK4) in SNU-1076 and OSC-19. 1-ethyl-2-benzimidazolinone 0-6 potassium calcium-activated channel subfamily N member 4 Homo sapiens 24-27 32701951-2 2020 METHODS: We evaluated the age-dependency of the neuroprotective effect of an SK3 agonist, 1-Ethyl-1,3-dihydro-2H-benzimidazol-2-one (1-EBIO), on Amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) excitotoxicity to DN in ventral mesencephalon (VM) organotypic cultures. 1-ethyl-2-benzimidazolinone 90-131 potassium calcium-activated channel subfamily N member 3 Homo sapiens 77-80 32701951-11 2020 At DIV 22, excitotoxicity was unaffected by 30 muM 1-EBIO, and partially reduced by 100 muM 1-EBIO. 1-ethyl-2-benzimidazolinone 92-98 latexin Homo sapiens 88-91 27432863-8 2016 In addition, apamin increased angiotensin II-stimulated aldosterone secretion, whereas 1-Ethyl-2-benzimidazolinone suppressed both angiotensin II- and high K(+)-stimulated production of aldosterone in H295R cells. 1-ethyl-2-benzimidazolinone 87-114 angiotensinogen Homo sapiens 131-145 28089668-2 2017 Induction of cardiomyogenesis and enrichment of nodal-like CMs was described for mouse pluripotent stem cells (mPSCs) in response to 1-ethyl-2-benzimidazolinone (EBIO), a chemical modulator of small-/intermediate-conductance Ca2+-activated potassium channels (SKs 1-4). 1-ethyl-2-benzimidazolinone 133-160 skin antigen 1 Mus musculus 260-267 26807020-8 2016 The 1-EBIO-induced current was abolished by TRAM-34, a selective SK4 blocker. 1-ethyl-2-benzimidazolinone 4-10 potassium calcium-activated channel subfamily N member 4 Homo sapiens 65-68 25583444-4 2015 Chemokines (CCL19 and CCL21) and KCa3.1 activator (1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) induced plasma membrane hyperpolarization and K(+) efflux, which was blocked by 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole, suggesting that KCa3.1 carried larger conductance than the inward calcium release-activated calcium channel. 1-ethyl-2-benzimidazolinone 51-92 potassium calcium-activated channel subfamily N member 4 Homo sapiens 33-39 25583444-4 2015 Chemokines (CCL19 and CCL21) and KCa3.1 activator (1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) induced plasma membrane hyperpolarization and K(+) efflux, which was blocked by 1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole, suggesting that KCa3.1 carried larger conductance than the inward calcium release-activated calcium channel. 1-ethyl-2-benzimidazolinone 51-92 potassium calcium-activated channel subfamily N member 4 Homo sapiens 238-244 25080203-4 2014 Treatment with the SK2 channel agonist 1-Ethyl-2-benzimidazolinone (1-EBIO) at 30 min after CA provided sustained protection from plasticity deficits, with LTP being maintained at control levels at 30 days after recovery from CA/CPR. 1-ethyl-2-benzimidazolinone 39-66 skin antigen 2 Mus musculus 19-22 25080203-4 2014 Treatment with the SK2 channel agonist 1-Ethyl-2-benzimidazolinone (1-EBIO) at 30 min after CA provided sustained protection from plasticity deficits, with LTP being maintained at control levels at 30 days after recovery from CA/CPR. 1-ethyl-2-benzimidazolinone 68-74 skin antigen 2 Mus musculus 19-22 25080203-10 2014 We concluded that CA/CPR caused alterations in post-synaptic signaling that were prevented by treatment with the SK2 agonist 1-EBIO, indicating that activators of SK2 channels may be useful therapeutic agents to prevent ischemic injury and cognitive impairments. 1-ethyl-2-benzimidazolinone 125-131 skin antigen 2 Mus musculus 113-116 25080203-10 2014 We concluded that CA/CPR caused alterations in post-synaptic signaling that were prevented by treatment with the SK2 agonist 1-EBIO, indicating that activators of SK2 channels may be useful therapeutic agents to prevent ischemic injury and cognitive impairments. 1-ethyl-2-benzimidazolinone 125-131 skin antigen 2 Mus musculus 163-166 23492185-8 2013 In addition, the KCa3.1 activator 1-ethylbenzimidazolinone-induced membrane hyperpolarization and intracellular calcium increase in asthmatic human BSMCs were attenuated by TRAM-34. 1-ethyl-2-benzimidazolinone 34-58 potassium calcium-activated channel subfamily N member 4 Homo sapiens 17-23 25096234-9 2014 Since K(Ca)2.3 specific currents could be increased in PC12 cells transfected with Endophilin A3 with DC-EBIO (30 microM), a known SK-channel activator, these data also implicate that Endophilin A3 did not significantly remove K(Ca)2.3 channels from the membrane but changed the sensitivity of the channels to Ca(2+) which could be overcome by DC-EBIO. 1-ethyl-2-benzimidazolinone 105-109 SH3 domain containing GRB2 like 3, endophilin A3 Rattus norvegicus 83-96 25096234-9 2014 Since K(Ca)2.3 specific currents could be increased in PC12 cells transfected with Endophilin A3 with DC-EBIO (30 microM), a known SK-channel activator, these data also implicate that Endophilin A3 did not significantly remove K(Ca)2.3 channels from the membrane but changed the sensitivity of the channels to Ca(2+) which could be overcome by DC-EBIO. 1-ethyl-2-benzimidazolinone 105-109 SH3 domain containing GRB2 like 3, endophilin A3 Rattus norvegicus 184-197 23776393-9 2013 Furthermore, KCa3.1 current, which was activated by clamping cells with 1 microM Ca(2+) and applying the KCa3.1 activator 1-ethyl-2-benzimidazolinone, was further augmented by TBHP, and inhibited by X/XO. 1-ethyl-2-benzimidazolinone 122-149 potassium calcium-activated channel subfamily N member 4 Homo sapiens 13-19 23776393-9 2013 Furthermore, KCa3.1 current, which was activated by clamping cells with 1 microM Ca(2+) and applying the KCa3.1 activator 1-ethyl-2-benzimidazolinone, was further augmented by TBHP, and inhibited by X/XO. 1-ethyl-2-benzimidazolinone 122-149 potassium calcium-activated channel subfamily N member 4 Homo sapiens 105-111 16566895-5 2006 Application of 50 microM 1-ethyl-2-benzimidazolone was able to potentiate SK3 current to the same extent as at neutral pH(i). 1-ethyl-2-benzimidazolinone 25-50 potassium calcium-activated channel subfamily N member 3 Homo sapiens 74-77 22989883-8 2012 Robust CFTR-dependent fluid secretion was also observed when cAMP stimulation was combined with direct pharmacological activation of epithelial K(+) channels with 1-ethyl-2-benzimidazolinone (EBIO). 1-ethyl-2-benzimidazolinone 163-190 cystic fibrosis transmembrane conductance regulator Mus musculus 7-11 22989883-8 2012 Robust CFTR-dependent fluid secretion was also observed when cAMP stimulation was combined with direct pharmacological activation of epithelial K(+) channels with 1-ethyl-2-benzimidazolinone (EBIO). 1-ethyl-2-benzimidazolinone 192-196 cystic fibrosis transmembrane conductance regulator Mus musculus 7-11 21712833-3 2011 Administration of the SK channel positive modulator, 1-ethyl-benzimidazolinone (1-EBIO), significantly reduced CA1 neuron cell death and improved CA/CPR-induced cognitive outcome. 1-ethyl-2-benzimidazolinone 53-78 carbonic anhydrase 1 Mus musculus 111-114 21712833-3 2011 Administration of the SK channel positive modulator, 1-ethyl-benzimidazolinone (1-EBIO), significantly reduced CA1 neuron cell death and improved CA/CPR-induced cognitive outcome. 1-ethyl-2-benzimidazolinone 80-86 carbonic anhydrase 1 Mus musculus 111-114 17047984-6 2006 The secretory response to 1-ethyl-2-benzimidazolinone, an activator of the basolateral Ca(2+)-activated K(+) channel KCNN4, was similarly reduced by butyrate treatment. 1-ethyl-2-benzimidazolinone 26-53 potassium calcium-activated channel subfamily N member 4 Homo sapiens 117-122 23437391-11 2013 1-EBIO enhanced whole cell currents which were abolished by TRAM-34 and reduced by apamin indicating activation of IK(Ca) and SK(Ca) respectively. 1-ethyl-2-benzimidazolinone 0-6 translocation associated membrane protein 1 Homo sapiens 60-64 22929778-6 2012 Here we demonstrate by X-ray crystallography that the binding pocket for the compounds of the 1-ethyl-2-benzimidazolinone (1-EBIO) class is located at the calmodulin-channel interface. 1-ethyl-2-benzimidazolinone 94-121 calmodulin 1 Homo sapiens 155-165 22929778-6 2012 Here we demonstrate by X-ray crystallography that the binding pocket for the compounds of the 1-ethyl-2-benzimidazolinone (1-EBIO) class is located at the calmodulin-channel interface. 1-ethyl-2-benzimidazolinone 123-129 calmodulin 1 Homo sapiens 155-165 21909392-2 2011 Previous studies demonstrated that the K+ channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl- secretion in cultured cells and mouse colon. 1-ethyl-2-benzimidazolinone 57-82 cystic fibrosis transmembrane conductance regulator Mus musculus 104-108 21909392-2 2011 Previous studies demonstrated that the K+ channel opener 1-ethyl-2-benzimidazolone (1-EBIO) potentiates CFTR-mediated Cl- secretion in cultured cells and mouse colon. 1-ethyl-2-benzimidazolinone 84-90 cystic fibrosis transmembrane conductance regulator Mus musculus 104-108 20616305-7 2010 The DC-EBIO-induced K(+) secretion was completely blocked by nonspecific (Ba(2+)) and Kcnn4-specific (TRAM-34) inhibitors, but was not blocked by the large-conductance K(+) (iberiotoxin), small-conductance K(+) (apamin), or KCNQ1 (chromanol 293B) specific blockers. 1-ethyl-2-benzimidazolinone 7-11 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 86-91 20616305-7 2010 The DC-EBIO-induced K(+) secretion was completely blocked by nonspecific (Ba(2+)) and Kcnn4-specific (TRAM-34) inhibitors, but was not blocked by the large-conductance K(+) (iberiotoxin), small-conductance K(+) (apamin), or KCNQ1 (chromanol 293B) specific blockers. 1-ethyl-2-benzimidazolinone 7-11 potassium voltage-gated channel subfamily Q member 1 Rattus norvegicus 224-229 20616305-9 2010 The DC-EBIO-enhanced anion secretion was completely inhibited by the nonspecific anion channel blocker 5-nitro-2-(3-phenylpropyl-amino)benzoic acid, whereas it was only partially inhibited by CFTR [CFTR(inh)-172, glibenclamide]- and CaCC (niflumic acid)-specific Cl(-) channel blockers. 1-ethyl-2-benzimidazolinone 7-11 CF transmembrane conductance regulator Rattus norvegicus 192-196 20616305-9 2010 The DC-EBIO-enhanced anion secretion was completely inhibited by the nonspecific anion channel blocker 5-nitro-2-(3-phenylpropyl-amino)benzoic acid, whereas it was only partially inhibited by CFTR [CFTR(inh)-172, glibenclamide]- and CaCC (niflumic acid)-specific Cl(-) channel blockers. 1-ethyl-2-benzimidazolinone 7-11 CF transmembrane conductance regulator Rattus norvegicus 198-211 16766578-4 2006 Moreover, 1-ethyl-2-benzimidazolinone (1-EBIO), which is known to activate KCNN4, increased G(K) with no effect on G(Na). 1-ethyl-2-benzimidazolinone 10-37 potassium calcium-activated channel subfamily N member 4 Homo sapiens 75-80 16766578-4 2006 Moreover, 1-ethyl-2-benzimidazolinone (1-EBIO), which is known to activate KCNN4, increased G(K) with no effect on G(Na). 1-ethyl-2-benzimidazolinone 39-45 potassium calcium-activated channel subfamily N member 4 Homo sapiens 75-80 16766578-6 2006 Subsequent studies showed that 1-EBIO stimulates Na(+) transport in polarized monolayers without affecting intracellular Ca(2+) concentration ([Ca(2+)](i)), suggesting that the activity of KCNN4 might influence the rate of Na(+) absorption by contributing to G(K). 1-ethyl-2-benzimidazolinone 31-37 potassium calcium-activated channel subfamily N member 4 Homo sapiens 189-194 11160649-7 2001 Compared with 1-EBIO, the most potent of these derivatives, DCEBIO (5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-one) was severalfold better in a 86Rb+ uptake assay, 20-fold better in short circuit current measurements on T84 monolayers, and 100-fold better in patch-clamp assays of hIK1 activity. 1-ethyl-2-benzimidazolinone 14-20 IKAROS family zinc finger 1 Homo sapiens 289-293 15993438-2 2005 We tested if the enhancement of the mI(AHP) by 1-ethyl-2-benzimidazolinone (EBIO) could suppress epileptiform activity in two in vitro models of epileptogenesis induced in CA3 hippocampal pyramidal neurons by superfusion with 4-AP- and kainate-Mg2+-free solutions. 1-ethyl-2-benzimidazolinone 76-80 carbonic anhydrase 3 Homo sapiens 172-175 15241346-3 2004 OBJECTIVE: To confirm the identity of this channel as iKCA1 in human lung mast cells and to examine the effect of an iKCA1 opener, 1-ethyl-2-benzimidazolinone (1-EBIO), on Ca2+ influx and degranulation after IgE-dependent activation. 1-ethyl-2-benzimidazolinone 131-158 potassium calcium-activated channel subfamily N member 4 Homo sapiens 117-122 12421833-0 2003 Unexpected down-regulation of the hIK1 Ca2+-activated K+ channel by its opener 1-ethyl-2-benzimidazolinone in HaCaT keratinocytes. 1-ethyl-2-benzimidazolinone 79-106 potassium calcium-activated channel subfamily N member 4 Homo sapiens 34-38 12421833-3 2003 When we incubated cells with the hIK1 opener, 1-ethyl-2-benzimidazolinone (1-EBIO), to investigate the cellular consequences of prolonged channel activity, an unexpected down-regulation of channels occurred within a few hours. 1-ethyl-2-benzimidazolinone 46-73 potassium calcium-activated channel subfamily N member 4 Homo sapiens 33-37 12421833-3 2003 When we incubated cells with the hIK1 opener, 1-ethyl-2-benzimidazolinone (1-EBIO), to investigate the cellular consequences of prolonged channel activity, an unexpected down-regulation of channels occurred within a few hours. 1-ethyl-2-benzimidazolinone 75-81 potassium calcium-activated channel subfamily N member 4 Homo sapiens 33-37 12383711-8 2002 1-Ethyl-2-benzimdazolinone (1-EBIO, a K(Ca) channel opener, 500 microM)- and ionomycin (Ca(2+) ionophore, 1 microM)-evoked Cl(-) secretions were also sensitive to CPZ. 1-ethyl-2-benzimidazolinone 28-34 casein kappa Homo sapiens 38-43 11181893-3 2001 When applied externally, chlorzoxazone, 1-EBIO, and zoxazolamine activated rSK2 channel currents in cells dialyzed with a nominally Ca(2+)-free intracellular solution. 1-ethyl-2-benzimidazolinone 40-46 potassium calcium-activated channel subfamily N member 2 Rattus norvegicus 75-79 11181893-6 2001 Activation of rSK2 channels by chlorzoxazone, 1-EBIO, and zoxazolamine declined at higher drug concentrations. 1-ethyl-2-benzimidazolinone 46-52 potassium calcium-activated channel subfamily N member 2 Rattus norvegicus 14-18 11181893-7 2001 Zoxazolamine, when applied in combination with chlorzoxazone or 1-EBIO, partially inhibited the rSK2 channel current responses, suggesting a partial-agonist mode of action. 1-ethyl-2-benzimidazolinone 64-70 potassium calcium-activated channel subfamily N member 2 Rattus norvegicus 96-100 12612194-7 2003 The K+ channel opener 1-ethyl-2-benzimidazolinone further increased CaCC-mediated Cl- secretion in normal and CF tissues. 1-ethyl-2-benzimidazolinone 22-49 chloride channel accessory 1 Homo sapiens 68-72 12466245-13 2002 Hyperpolarizations of intact endothelium elicited by substance P (100 nM; 26.1+/-0.7 mV) were reduced by apamin (100 nM; 17.0+/-1.8 mV) whereas those to 1-ethyl-2-benzimidazolinone (1-EBIO, 600 microM, 21.0+/-0.3 mV) were unaffected (21.7+/-0.8 mV). 1-ethyl-2-benzimidazolinone 153-180 tachykinin precursor 1 Homo sapiens 53-64 12466245-13 2002 Hyperpolarizations of intact endothelium elicited by substance P (100 nM; 26.1+/-0.7 mV) were reduced by apamin (100 nM; 17.0+/-1.8 mV) whereas those to 1-ethyl-2-benzimidazolinone (1-EBIO, 600 microM, 21.0+/-0.3 mV) were unaffected (21.7+/-0.8 mV). 1-ethyl-2-benzimidazolinone 184-188 tachykinin precursor 1 Homo sapiens 53-64 12163354-7 2002 Perfusion at the intracellular face of the cell, of an opener of intermediate conductance K(Ca) channel, 500 micro M 1-ethyl-benzimidazolinone (1-EBIO) increased the channel activity by about 4.5 fold. 1-ethyl-2-benzimidazolinone 117-142 casein kappa Homo sapiens 90-95 12163354-7 2002 Perfusion at the intracellular face of the cell, of an opener of intermediate conductance K(Ca) channel, 500 micro M 1-ethyl-benzimidazolinone (1-EBIO) increased the channel activity by about 4.5 fold. 1-ethyl-2-benzimidazolinone 144-150 casein kappa Homo sapiens 90-95 10712246-1 2000 We previously characterized 1-ethyl-2-benzimidazolinone (1-EBIO), as well as the clinically useful benzoxazoles, chlorzoxazone (CZ), and zoxazolamine (ZOX), as pharmacological activators of the intermediate-conductance Ca(2+)-activated K(+) channel, hIK1. 1-ethyl-2-benzimidazolinone 28-55 IKAROS family zinc finger 1 Homo sapiens 250-254 11509830-7 2001 1-ethyl-2-benzimidazolinone (1-EBIO), a known activator of SK4/IK1 channels, also activated rSK4. 1-ethyl-2-benzimidazolinone 0-27 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 59-62 11509830-7 2001 1-ethyl-2-benzimidazolinone (1-EBIO), a known activator of SK4/IK1 channels, also activated rSK4. 1-ethyl-2-benzimidazolinone 0-27 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 63-66 11509830-7 2001 1-ethyl-2-benzimidazolinone (1-EBIO), a known activator of SK4/IK1 channels, also activated rSK4. 1-ethyl-2-benzimidazolinone 0-27 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 92-96 11509830-7 2001 1-ethyl-2-benzimidazolinone (1-EBIO), a known activator of SK4/IK1 channels, also activated rSK4. 1-ethyl-2-benzimidazolinone 29-35 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 59-62 11509830-7 2001 1-ethyl-2-benzimidazolinone (1-EBIO), a known activator of SK4/IK1 channels, also activated rSK4. 1-ethyl-2-benzimidazolinone 29-35 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 63-66 11509830-7 2001 1-ethyl-2-benzimidazolinone (1-EBIO), a known activator of SK4/IK1 channels, also activated rSK4. 1-ethyl-2-benzimidazolinone 29-35 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 92-96 11509830-8 2001 1-EBIO affected the current neither at saturating Ca(2+) activities nor under Ca(2+)-free conditions, but increased the Ca(2+) sensitivity of rSK4. 1-ethyl-2-benzimidazolinone 0-6 potassium calcium-activated channel subfamily N member 4 Rattus norvegicus 142-146 10712246-3 2000 1-EBIO, CZ, and ZOX activated both hIK1 and rSK2 in TEVC and excised inside-out patch-clamp experiments. 1-ethyl-2-benzimidazolinone 0-6 IKAROS family zinc finger 1 Homo sapiens 35-39 10712246-3 2000 1-EBIO, CZ, and ZOX activated both hIK1 and rSK2 in TEVC and excised inside-out patch-clamp experiments. 1-ethyl-2-benzimidazolinone 0-6 potassium calcium-activated channel subfamily N member 2 Rattus norvegicus 44-48 10712246-12 2000 In conclusion, we define 1-EBIO, CZ, and ZOX as the first known activators of hIK1 and rSK2. 1-ethyl-2-benzimidazolinone 25-31 IKAROS family zinc finger 1 Homo sapiens 78-82 10712246-12 2000 In conclusion, we define 1-EBIO, CZ, and ZOX as the first known activators of hIK1 and rSK2. 1-ethyl-2-benzimidazolinone 25-31 potassium calcium-activated channel subfamily N member 2 Rattus norvegicus 87-91 9277350-2 1997 We used 1-ethyl-2-benzimidazolinone (1-EBIO) to activate the Ca(2+)-dependent K+ channel (KCa) in these cells to induce a sustained Cl- secretory current (Isc). 1-ethyl-2-benzimidazolinone 8-35 casein kappa Homo sapiens 90-93 9277350-2 1997 We used 1-ethyl-2-benzimidazolinone (1-EBIO) to activate the Ca(2+)-dependent K+ channel (KCa) in these cells to induce a sustained Cl- secretory current (Isc). 1-ethyl-2-benzimidazolinone 37-43 casein kappa Homo sapiens 90-93