PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
32853367-2	2020	The enhancer Ealpha plays an essential role in Tcra rearrangement by establishing a recombination centre in the Jalpha array and a chromatin hub for interactions between Valpha and Jalpha genes.	valpha	170-176	T cell receptor alpha joining 60 (pseudogene)	Homo sapiens	47-51
9730891-3	1998	By fixing TCR-beta chains with a single rearranged TCR-beta irrelevant to the selecting ligand, we show here that T cells selected to mature on a single MHC-peptide complex express highly restricted TCR-alpha chains in terms of Valpha usage and amino acid residue of their CDR3 loops, whereas such restriction was not observed with those selected by the same MHC with diverse sets of self-peptides including this peptide.	valpha	228-234	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	10-18
9730891-3	1998	By fixing TCR-beta chains with a single rearranged TCR-beta irrelevant to the selecting ligand, we show here that T cells selected to mature on a single MHC-peptide complex express highly restricted TCR-alpha chains in terms of Valpha usage and amino acid residue of their CDR3 loops, whereas such restriction was not observed with those selected by the same MHC with diverse sets of self-peptides including this peptide.	valpha	228-234	T cell receptor alpha constant	Homo sapiens	199-208
9692880-4	1998	Possession of a Valpha chain which is inefficiently positively selected appears to increase the likelihood that a second Valpha chain will be co-expressed, whilst the relative cell surface levels of a given pair of Valpha chains differ between CD4 and CD8 subsets.	valpha	16-22	CD4 antigen	Mus musculus	244-247
10770802-3	2000	The TCR energy maps for QL9/L(d) and SIYR/K(b) were remarkably similar, in that 16 of 41 Valpha and Vbeta alanine mutants showed reduced binding to both ligands.	valpha	89-95	T cell receptor beta variable 20/OR9-2 (non-functional)	Homo sapiens	4-7
34910107-3	2022	Here, by ablating Tcrd recombination, we report that Tcrd rearrangement broadens primary Valpha use to diversify the Tcra repertoire in mice.	valpha	89-95	T cell receptor delta chain	Mus musculus	18-22
34910107-3	2022	Here, by ablating Tcrd recombination, we report that Tcrd rearrangement broadens primary Valpha use to diversify the Tcra repertoire in mice.	valpha	89-95	T cell receptor delta chain	Mus musculus	53-57
34910107-3	2022	Here, by ablating Tcrd recombination, we report that Tcrd rearrangement broadens primary Valpha use to diversify the Tcra repertoire in mice.	valpha	89-95	T cell receptor alpha chain	Mus musculus	117-121
21345791-4	2011	In this experimental design, we have shown that Valpha, which is an effective synchronous blocker of VEGF-A and TNF-alpha, can drastically increase treatment effectiveness through its dual-blocking characteristics.	valpha	48-54	vascular endothelial growth factor A	Homo sapiens	101-107
21345791-4	2011	In this experimental design, we have shown that Valpha, which is an effective synchronous blocker of VEGF-A and TNF-alpha, can drastically increase treatment effectiveness through its dual-blocking characteristics.	valpha	48-54	tumor necrosis factor	Homo sapiens	112-121
21345791-6	2011	Valpha exhibited strong binding characteristics for its original counterparts, VEGF-A and TNF-alpha, but not for the extracellular matrix, resulting in a highly favorable pharmacokinetic profile in vivo.	valpha	0-6	vascular endothelial growth factor A	Homo sapiens	79-85
21345791-6	2011	Valpha exhibited strong binding characteristics for its original counterparts, VEGF-A and TNF-alpha, but not for the extracellular matrix, resulting in a highly favorable pharmacokinetic profile in vivo.	valpha	0-6	tumor necrosis factor	Homo sapiens	90-99
21345791-7	2011	Compared with VEGF-Trap or Enbrel, both of which block either VEGF-A or TNF-alpha, singularly, Valpha is a highly effective molecule for reducing abnormal vascular tufts and the number of F4/80(+) macrophages in a retinopathy model.	valpha	95-101	vascular endothelial growth factor A	Homo sapiens	62-68
21345791-7	2011	Compared with VEGF-Trap or Enbrel, both of which block either VEGF-A or TNF-alpha, singularly, Valpha is a highly effective molecule for reducing abnormal vascular tufts and the number of F4/80(+) macrophages in a retinopathy model.	valpha	95-101	tumor necrosis factor	Homo sapiens	72-81
21345791-9	2011	Thus, the simultaneous blocking of VEGF-A and TNF-alpha using Valpha is an effective therapeutic strategy and cost-efficient for treatment of retinopathy and psoriasis.	valpha	62-68	vascular endothelial growth factor A	Homo sapiens	35-41
21345791-9	2011	Thus, the simultaneous blocking of VEGF-A and TNF-alpha using Valpha is an effective therapeutic strategy and cost-efficient for treatment of retinopathy and psoriasis.	valpha	62-68	tumor necrosis factor	Homo sapiens	46-55
24150607-7	2014	We also analyzed transcript clonality of rat TCR-Valpha5, an ortholog of the dominant TCR-Valpha chain found on insulin B:9-23-reactive T cells in nonobese diabetic rat islets.	valpha	49-55	T cell receptor alpha variable 12-3	Rattus norvegicus	45-48
24150607-7	2014	We also analyzed transcript clonality of rat TCR-Valpha5, an ortholog of the dominant TCR-Valpha chain found on insulin B:9-23-reactive T cells in nonobese diabetic rat islets.	valpha	49-55	T cell receptor alpha variable 12-3	Rattus norvegicus	86-89
17710651-2	2007	We showed that activation of Valpha-14(+) hybridomas by dendritic cells or other CD1d-expressing cells was altered by disruption of lipid rafts with the cholesterol chelator MbetaCD.	valpha	29-35	CD1d molecule	Homo sapiens	81-85
12023346-6	2002	In conclusion, our results demonstrate that, contrary to the currently held view, recognition of CD1d-alphaGC complex in humans is not uniformly restricted to the Valpha24-JalphaQ/Vbeta11 NKT cell subset, but can be mediated by a diverse range of Valpha and Vbeta domains.	valpha	163-169	CD1d molecule	Homo sapiens	97-101
11592067-2	2001	Functional TCRalpha chain transcripts generated by Valpha-gene replacement at the site of the Valpha-embedded heptamer were identified in splenic T cells.	valpha	51-57	T cell receptor alpha chain	Mus musculus	11-19