PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
33031879-3	2021	An in vitro HaCaT inflammation model treated with dictamnine, which efficiently scavenged the reactive oxygen species (ROS) and mitochondrial ROS (mROS), and it reduced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) expression, NLRP3 inflammasome activation, and NF-kappaB expression.	dictamnine	50-60	interleukin 1 beta	Mus musculus	169-186
33031879-3	2021	An in vitro HaCaT inflammation model treated with dictamnine, which efficiently scavenged the reactive oxygen species (ROS) and mitochondrial ROS (mROS), and it reduced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) expression, NLRP3 inflammasome activation, and NF-kappaB expression.	dictamnine	50-60	interleukin 1 alpha	Mus musculus	188-196
33031879-3	2021	An in vitro HaCaT inflammation model treated with dictamnine, which efficiently scavenged the reactive oxygen species (ROS) and mitochondrial ROS (mROS), and it reduced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) expression, NLRP3 inflammasome activation, and NF-kappaB expression.	dictamnine	50-60	tumor necrosis factor	Mus musculus	199-226
33031879-3	2021	An in vitro HaCaT inflammation model treated with dictamnine, which efficiently scavenged the reactive oxygen species (ROS) and mitochondrial ROS (mROS), and it reduced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) expression, NLRP3 inflammasome activation, and NF-kappaB expression.	dictamnine	50-60	tumor necrosis factor	Mus musculus	228-237
33031879-3	2021	An in vitro HaCaT inflammation model treated with dictamnine, which efficiently scavenged the reactive oxygen species (ROS) and mitochondrial ROS (mROS), and it reduced interleukin-1beta (IL-1beta), tumor necrosis factor-alpha (TNF-alpha) expression, NLRP3 inflammasome activation, and NF-kappaB expression.	dictamnine	50-60	NLR family, pyrin domain containing 3	Mus musculus	251-256
34861243-0	2022	Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways.	dictamnine	0-10	MET proto-oncogene, receptor tyrosine kinase	Homo sapiens	20-25
34861243-0	2022	Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways.	dictamnine	0-10	AKT serine/threonine kinase 1	Homo sapiens	114-117
34861243-0	2022	Dictamnine, a novel c-Met inhibitor, suppresses the proliferation of lung cancer cells by downregulating the PI3K/AKT/mTOR and MAPK signaling pathways.	dictamnine	0-10	mechanistic target of rapamycin kinase	Homo sapiens	118-122
34595163-9	2021	Dictamnine caused increased oxidative stress and early hepatic apoptosis via up-regulation of glutathione S transferase a1 (GSTA1) and Bax/Bcl-2 ratio and down-regulation of the antioxidative enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase 1 (GPx-1).	dictamnine	0-10	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	94-122
34595163-9	2021	Dictamnine caused increased oxidative stress and early hepatic apoptosis via up-regulation of glutathione S transferase a1 (GSTA1) and Bax/Bcl-2 ratio and down-regulation of the antioxidative enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase 1 (GPx-1).	dictamnine	0-10	glutathione S-transferase, alpha 1 (Ya)	Mus musculus	124-129
34595163-9	2021	Dictamnine caused increased oxidative stress and early hepatic apoptosis via up-regulation of glutathione S transferase a1 (GSTA1) and Bax/Bcl-2 ratio and down-regulation of the antioxidative enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase 1 (GPx-1).	dictamnine	0-10	BCL2-associated X protein	Mus musculus	135-138
34595163-9	2021	Dictamnine caused increased oxidative stress and early hepatic apoptosis via up-regulation of glutathione S transferase a1 (GSTA1) and Bax/Bcl-2 ratio and down-regulation of the antioxidative enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase 1 (GPx-1).	dictamnine	0-10	B cell leukemia/lymphoma 2	Mus musculus	139-144
34595163-9	2021	Dictamnine caused increased oxidative stress and early hepatic apoptosis via up-regulation of glutathione S transferase a1 (GSTA1) and Bax/Bcl-2 ratio and down-regulation of the antioxidative enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase 1 (GPx-1).	dictamnine	0-10	catalase	Mus musculus	228-236
34595163-9	2021	Dictamnine caused increased oxidative stress and early hepatic apoptosis via up-regulation of glutathione S transferase a1 (GSTA1) and Bax/Bcl-2 ratio and down-regulation of the antioxidative enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase 1 (GPx-1).	dictamnine	0-10	glutathione peroxidase 1	Mus musculus	242-266
34595163-9	2021	Dictamnine caused increased oxidative stress and early hepatic apoptosis via up-regulation of glutathione S transferase a1 (GSTA1) and Bax/Bcl-2 ratio and down-regulation of the antioxidative enzymes superoxide dismutase (SOD), catalase, and glutathione peroxidase 1 (GPx-1).	dictamnine	0-10	glutathione peroxidase 1	Mus musculus	268-273
31812602-6	2020	Notably, 640 mg/kg DTN exposure increased hepatic GSH, GSH peroxidase, superoxide dismutase and malondialdehyde, and decreased ROS, together with altered expression of Idh2 and Nedd9.	dictamnine	19-22	isocitrate dehydrogenase 2 (NADP+), mitochondrial	Mus musculus	168-172
31812602-6	2020	Notably, 640 mg/kg DTN exposure increased hepatic GSH, GSH peroxidase, superoxide dismutase and malondialdehyde, and decreased ROS, together with altered expression of Idh2 and Nedd9.	dictamnine	19-22	neural precursor cell expressed, developmentally down-regulated gene 9	Mus musculus	177-182
30578885-2	2019	As the most abundant furoquinoline alkaloid ingredient of Cortex Dictamni, dictamnine (DIC) can be metabolically activated by CYP3A to an epoxide metabolite, which possesses the potential to induce hepatotoxicity by covalent binding with proteins.	dictamnine	75-85	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	126-131
30578885-2	2019	As the most abundant furoquinoline alkaloid ingredient of Cortex Dictamni, dictamnine (DIC) can be metabolically activated by CYP3A to an epoxide metabolite, which possesses the potential to induce hepatotoxicity by covalent binding with proteins.	dictamnine	87-90	cytochrome P450, family 3, subfamily a, polypeptide 11	Mus musculus	126-131
30266538-0	2018	Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1alpha and Slug signaling pathways.	dictamnine	0-10	hypoxia inducible factor 1 subunit alpha	Homo sapiens	138-148
30266538-0	2018	Dictamnine promotes apoptosis and inhibits epithelial-mesenchymal transition, migration, invasion and proliferation by downregulating the HIF-1alpha and Slug signaling pathways.	dictamnine	0-10	snail family transcriptional repressor 2	Homo sapiens	153-157
30266538-4	2018	Here, dictamnine showed the potent inhibitory activity against HIF-1alpha and Slug activation induced by hypoxia in various human cancer cell lines.	dictamnine	6-16	hypoxia inducible factor 1 subunit alpha	Homo sapiens	63-73
30266538-4	2018	Here, dictamnine showed the potent inhibitory activity against HIF-1alpha and Slug activation induced by hypoxia in various human cancer cell lines.	dictamnine	6-16	snail family transcriptional repressor 2	Homo sapiens	78-82
30266538-6	2018	Further analysis revealed that dictamnine inhibited HIF-1alpha protein synthesis, without affecting its degradation.	dictamnine	31-41	hypoxia inducible factor 1 subunit alpha	Homo sapiens	52-62
30266538-7	2018	Our results demonstrated that dictamnine reduced HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/eIF4E and MAPK pathways, and reduced the expression of Slug by inhibiting the GSK-3beta/Slug signaling pathway.	dictamnine	30-40	hypoxia inducible factor 1 subunit alpha	Homo sapiens	49-59
30266538-7	2018	Our results demonstrated that dictamnine reduced HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/eIF4E and MAPK pathways, and reduced the expression of Slug by inhibiting the GSK-3beta/Slug signaling pathway.	dictamnine	30-40	mechanistic target of rapamycin kinase	Homo sapiens	100-104
30266538-7	2018	Our results demonstrated that dictamnine reduced HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/eIF4E and MAPK pathways, and reduced the expression of Slug by inhibiting the GSK-3beta/Slug signaling pathway.	dictamnine	30-40	ribosomal protein S6 kinase B1	Homo sapiens	105-111
30266538-7	2018	Our results demonstrated that dictamnine reduced HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/eIF4E and MAPK pathways, and reduced the expression of Slug by inhibiting the GSK-3beta/Slug signaling pathway.	dictamnine	30-40	eukaryotic translation initiation factor 4E	Homo sapiens	112-117
30266538-7	2018	Our results demonstrated that dictamnine reduced HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/eIF4E and MAPK pathways, and reduced the expression of Slug by inhibiting the GSK-3beta/Slug signaling pathway.	dictamnine	30-40	snail family transcriptional repressor 2	Homo sapiens	167-171
30266538-7	2018	Our results demonstrated that dictamnine reduced HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/eIF4E and MAPK pathways, and reduced the expression of Slug by inhibiting the GSK-3beta/Slug signaling pathway.	dictamnine	30-40	glycogen synthase kinase 3 beta	Homo sapiens	190-199
30266538-7	2018	Our results demonstrated that dictamnine reduced HIF-1alpha protein synthesis by downregulating the mTOR/p70S6K/eIF4E and MAPK pathways, and reduced the expression of Slug by inhibiting the GSK-3beta/Slug signaling pathway.	dictamnine	30-40	snail family transcriptional repressor 2	Homo sapiens	200-204
30266538-8	2018	Moreover, epithelial-mesenchymal transition (EMT) was inhibited in dictamnine-treated tumors by downregulation of HIF-1alpha and Slug, as reflected by the upregulation of E-cadherin and Occludin, and the downregulation of N-cadherin and Vimentin.	dictamnine	67-77	hypoxia inducible factor 1 subunit alpha	Homo sapiens	114-124
30266538-8	2018	Moreover, epithelial-mesenchymal transition (EMT) was inhibited in dictamnine-treated tumors by downregulation of HIF-1alpha and Slug, as reflected by the upregulation of E-cadherin and Occludin, and the downregulation of N-cadherin and Vimentin.	dictamnine	67-77	snail family transcriptional repressor 2	Homo sapiens	129-133
30266538-8	2018	Moreover, epithelial-mesenchymal transition (EMT) was inhibited in dictamnine-treated tumors by downregulation of HIF-1alpha and Slug, as reflected by the upregulation of E-cadherin and Occludin, and the downregulation of N-cadherin and Vimentin.	dictamnine	67-77	cadherin 1	Homo sapiens	171-181
30266538-8	2018	Moreover, epithelial-mesenchymal transition (EMT) was inhibited in dictamnine-treated tumors by downregulation of HIF-1alpha and Slug, as reflected by the upregulation of E-cadherin and Occludin, and the downregulation of N-cadherin and Vimentin.	dictamnine	67-77	occludin	Homo sapiens	186-194
30266538-8	2018	Moreover, epithelial-mesenchymal transition (EMT) was inhibited in dictamnine-treated tumors by downregulation of HIF-1alpha and Slug, as reflected by the upregulation of E-cadherin and Occludin, and the downregulation of N-cadherin and Vimentin.	dictamnine	67-77	cadherin 2	Homo sapiens	222-232
30266538-8	2018	Moreover, epithelial-mesenchymal transition (EMT) was inhibited in dictamnine-treated tumors by downregulation of HIF-1alpha and Slug, as reflected by the upregulation of E-cadherin and Occludin, and the downregulation of N-cadherin and Vimentin.	dictamnine	67-77	vimentin	Homo sapiens	237-245
30266538-9	2018	Phenomenological experiments showed that dictamnine reduced migration and invasion, inhibited HCT116 cell proliferation and promoted HCT116 cell apoptosis by downregulating HIF-1alpha and Slug.	dictamnine	41-51	hypoxia inducible factor 1 subunit alpha	Homo sapiens	173-183
30266538-9	2018	Phenomenological experiments showed that dictamnine reduced migration and invasion, inhibited HCT116 cell proliferation and promoted HCT116 cell apoptosis by downregulating HIF-1alpha and Slug.	dictamnine	41-51	snail family transcriptional repressor 2	Homo sapiens	188-192
30662787-1	2018	Dictamnine (4-methoxyfuro[2,3-b]quinolone, DIC), a common furoquinoline alkaloid in the family of Rutaceae, showed diverse biological activities.	dictamnine	0-10	solute carrier family 25 (mitochondrial carrier, dicarboxylate transporter), member 10	Mus musculus	43-46
30283337-0	2018	The Modulatory Role of CYP3A4 in Dictamnine-Induced Hepatotoxicity.	dictamnine	33-43	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	23-29
30283337-3	2018	Dictamnine (DTN), the main alkaloid from DC, possesses a furan ring which was suspected of being responsible for hepatotoxicity via metabolic activation primarily by CYP3A4.	dictamnine	0-10	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	166-172
30283337-3	2018	Dictamnine (DTN), the main alkaloid from DC, possesses a furan ring which was suspected of being responsible for hepatotoxicity via metabolic activation primarily by CYP3A4.	dictamnine	12-15	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	166-172
30283337-4	2018	Herein, the present study aimed to evaluate the role of CYP3A4 in DTN-induced liver injury.	dictamnine	66-69	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	56-62
30283337-10	2018	Collectively, our findings illustrated that DTN-induced hepatotoxicity correlated well with the expression of CYP3A4, namely inhibition of CYP3A4 alleviated the toxicity both in vitro and in vivo, and induction aggravated the toxicity effects.	dictamnine	44-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	110-116
30283337-10	2018	Collectively, our findings illustrated that DTN-induced hepatotoxicity correlated well with the expression of CYP3A4, namely inhibition of CYP3A4 alleviated the toxicity both in vitro and in vivo, and induction aggravated the toxicity effects.	dictamnine	44-47	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	139-145
26683990-11	2016	A chemical inhibition study with a broad and five specific CYP450 inhibitors revealed that most of the dictamnine metabolites in liver microsomes are mediated by CYP450, with CYP3A4 as the predominant enzyme involved in the formation of M7, the major metabolite.	dictamnine	103-113	cytochrome P450 family 3 subfamily A member 4	Homo sapiens	175-181