PMID-sentid	Pub_year	Sent_text	compound_name	comp_offset	prot_official_name	organism	prot_offset
35545086-0	2022	Chitosan oligosaccharides exert neuroprotective effects via modulating the PI3K/Akt/Bcl-2 pathway in a Parkinsonian model.	chitosan oligosaccharides	0-25	thymoma viral proto-oncogene 1	Mus musculus	80-83
35545086-0	2022	Chitosan oligosaccharides exert neuroprotective effects via modulating the PI3K/Akt/Bcl-2 pathway in a Parkinsonian model.	chitosan oligosaccharides	0-25	B cell leukemia/lymphoma 2	Mus musculus	84-89
27178341-0	2016	Chitosan oligosaccharides inhibit IL-1beta-induced chondrocyte apoptosis via the P38 MAPK signaling pathway.	chitosan oligosaccharides	0-25	interleukin 1 beta	Homo sapiens	34-42
32183067-0	2020	Chitosan Oligosaccharides Attenuate Amyloid Formation of hIAPP and Protect Pancreatic beta-Cells from Cytotoxicity.	chitosan oligosaccharides	0-25	islet amyloid polypeptide	Homo sapiens	57-62
30463189-0	2018	Chitosan Oligosaccharides Improve Glucolipid Metabolism Disorder in Liver by Suppression of Obesity-Related Inflammation and Restoration of Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma).	chitosan oligosaccharides	0-25	peroxisome proliferator activated receptor gamma	Homo sapiens	140-188
30463189-0	2018	Chitosan Oligosaccharides Improve Glucolipid Metabolism Disorder in Liver by Suppression of Obesity-Related Inflammation and Restoration of Peroxisome Proliferator-Activated Receptor Gamma (PPARgamma).	chitosan oligosaccharides	0-25	peroxisome proliferator activated receptor gamma	Homo sapiens	190-199
29548750-0	2018	Chitosan oligosaccharides enhance lipid droplets via down-regulation of PCSK9 gene expression in HepG2 cells.	chitosan oligosaccharides	0-25	proprotein convertase subtilisin/kexin type 9	Homo sapiens	72-77
28299836-0	2018	Involvement of PKA signalling in anti-inflammatory effects of chitosan oligosaccharides in IPEC-J2 porcine epithelial cells.	chitosan oligosaccharides	62-87	protein kinase cAMP-activated catalytic subunit alpha	Sus scrofa	15-18
28700003-0	2017	The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model.	chitosan oligosaccharides	15-40	TNF receptor superfamily member 11B	Rattus norvegicus	44-47
28700003-0	2017	The effects of chitosan oligosaccharides on OPG and RANKL expression in a rat osteoarthritis model.	chitosan oligosaccharides	15-40	TNF superfamily member 11	Rattus norvegicus	52-57
28700003-12	2017	Conclusion: : Chitosan oligosaccharides may be used as a unique biological agent to prevent and treat osteoarthritis, and this effect is associated with modulation of the expression of osteoprotegerin and receptor activator of NF-kappaB ligand.	chitosan oligosaccharides	14-39	TNF receptor superfamily member 11B	Rattus norvegicus	185-200
28700003-12	2017	Conclusion: : Chitosan oligosaccharides may be used as a unique biological agent to prevent and treat osteoarthritis, and this effect is associated with modulation of the expression of osteoprotegerin and receptor activator of NF-kappaB ligand.	chitosan oligosaccharides	14-39	TNF superfamily member 11	Rattus norvegicus	205-243
35401926-0	2022	Chitosan Oligosaccharides Alleviate H2O2-stimulated Granulosa Cell Damage via HIF-1alpha Signaling Pathway.	chitosan oligosaccharides	0-25	hypoxia inducible factor 1 subunit alpha	Homo sapiens	78-88
35200626-0	2022	Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARgamma/SIRT1-Mediated NF-kappaB Pathway.	chitosan oligosaccharides	0-25	peroxisome proliferator activated receptor gamma	Mus musculus	84-93
35200626-0	2022	Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARgamma/SIRT1-Mediated NF-kappaB Pathway.	chitosan oligosaccharides	0-25	sirtuin 1	Mus musculus	94-99
35200626-0	2022	Chitosan Oligosaccharides Alleviate Colitis by Regulating Intestinal Microbiota and PPARgamma/SIRT1-Mediated NF-kappaB Pathway.	chitosan oligosaccharides	0-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	109-118
30928397-0	2019	Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway.	chitosan oligosaccharides	0-25	mitogen activated protein kinase 14	Rattus norvegicus	112-115
30928397-0	2019	Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway.	chitosan oligosaccharides	0-25	mitogen-activated protein kinase 8	Rattus norvegicus	120-123
30928397-0	2019	Chitosan oligosaccharides prevent doxorubicin-induced oxidative stress and cardiac apoptosis through activating p38 and JNK MAPK mediated Nrf2/ARE pathway.	chitosan oligosaccharides	0-25	NFE2 like bZIP transcription factor 2	Rattus norvegicus	138-142
30237293-5	2018	Using microfluidic experiments, we showed that stabilization of the endothelial glycocalyx by chitosan oligosaccharides or overexpression of syndecan-1 (SDC-1) significantly supports the binding of VWF fibers to endothelial cells.	chitosan oligosaccharides	94-119	Von Willebrand factor	Mus musculus	198-201
29175631-0	2018	The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells.	chitosan oligosaccharides	25-50	beta-secretase 1	Homo sapiens	54-107
29175631-0	2018	The inhibitory effect of chitosan oligosaccharides on beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) in HEK293 APPswe cells.	chitosan oligosaccharides	25-50	beta-secretase 1	Homo sapiens	109-114
28521993-0	2017	Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure.	chitosan oligosaccharides	0-25	alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase	Homo sapiens	80-113
27178341-0	2016	Chitosan oligosaccharides inhibit IL-1beta-induced chondrocyte apoptosis via the P38 MAPK signaling pathway.	chitosan oligosaccharides	0-25	mitogen-activated protein kinase 14	Homo sapiens	81-84
25387351-0	2014	Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-kappaB inactivation.	chitosan oligosaccharides	9-34	toll-like receptor 4	Mus musculus	44-47
25775423-0	2015	Acetylated chitosan oligosaccharides act as antagonists against glutamate-induced PC12 cell death via Bcl-2/Bax signal pathway.	chitosan oligosaccharides	11-36	BCL2, apoptosis regulator	Rattus norvegicus	102-107
25775423-0	2015	Acetylated chitosan oligosaccharides act as antagonists against glutamate-induced PC12 cell death via Bcl-2/Bax signal pathway.	chitosan oligosaccharides	11-36	BCL2 associated X, apoptosis regulator	Rattus norvegicus	108-111
25387351-0	2014	Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-kappaB inactivation.	chitosan oligosaccharides	9-34	mitogen-activated protein kinase 8	Mus musculus	74-77
25387351-0	2014	Sulfated chitosan oligosaccharides suppress LPS-induced NO production via JNK and NF-kappaB inactivation.	chitosan oligosaccharides	9-34	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	82-91
25387351-3	2014	The results showed that pretreated low molecular weight sulfated chitosan oligosaccharides inhibited the production of nitric oxide (NO) and inflammatory cytokines such as IL-6 and TNF-alpha in lipopolysaccharide (LPS)-activated RAW264.7 cells.	chitosan oligosaccharides	65-90	interleukin 6	Mus musculus	172-176
25387351-3	2014	The results showed that pretreated low molecular weight sulfated chitosan oligosaccharides inhibited the production of nitric oxide (NO) and inflammatory cytokines such as IL-6 and TNF-alpha in lipopolysaccharide (LPS)-activated RAW264.7 cells.	chitosan oligosaccharides	65-90	tumor necrosis factor	Mus musculus	181-190
25387351-3	2014	The results showed that pretreated low molecular weight sulfated chitosan oligosaccharides inhibited the production of nitric oxide (NO) and inflammatory cytokines such as IL-6 and TNF-alpha in lipopolysaccharide (LPS)-activated RAW264.7 cells.	chitosan oligosaccharides	65-90	toll-like receptor 4	Mus musculus	214-217
24274545-0	2014	Chitosan oligosaccharides block LPS-induced O-GlcNAcylation of NF-kappaB and endothelial inflammatory response.	chitosan oligosaccharides	0-25	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	63-72
24336934-0	2014	Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling.	chitosan oligosaccharides	0-25	selectin E	Homo sapiens	57-67
24336934-0	2014	Chitosan oligosaccharides downregulate the expression of E-selectin and ICAM-1 induced by LPS in endothelial cells by inhibiting MAP kinase signaling.	chitosan oligosaccharides	0-25	intercellular adhesion molecule 1	Homo sapiens	72-78
24274545-1	2014	It is known that chitosan oligosaccharides (COS) suppress LPS-induced vascular endothelial inflammatory response by mechanism involving NF-kappaB blockade.	chitosan oligosaccharides	17-42	nuclear factor of kappa light polypeptide gene enhancer in B cells 1, p105	Mus musculus	136-145
22302708-0	2012	Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice.	chitosan oligosaccharides	0-25	scavenger receptor class B, member 1	Mus musculus	82-103
22302708-0	2012	Chitosan oligosaccharides promote reverse cholesterol transport and expression of scavenger receptor BI and CYP7A1 in mice.	chitosan oligosaccharides	0-25	cytochrome P450, family 7, subfamily a, polypeptide 1	Mus musculus	108-114
21468084-0	2011	Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases.	chitosan oligosaccharides	0-25	C-X-C motif chemokine ligand 8	Homo sapiens	47-51
21468084-0	2011	Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases.	chitosan oligosaccharides	0-25	mitogen-activated protein kinase 14	Homo sapiens	125-128
21468084-0	2011	Chitosan oligosaccharides suppress LPS-induced IL-8 expression in human umbilical vein endothelial cells through blockade of p38 and Akt protein kinases.	chitosan oligosaccharides	0-25	AKT serine/threonine kinase 1	Homo sapiens	133-136
19597323-1	2009	The present study investigated the antimetastatic property of chitosan oligosaccharides (COS) by evaluating motility, invasion, and the amount and activity of MMP-9 in MDA-MB-231 human breast carcinoma cells.	chitosan oligosaccharides	62-87	matrix metallopeptidase 9	Homo sapiens	159-164
22266066-0	2012	Anti-inflammatory effects of low-molecular weight chitosan oligosaccharides in IgE-antigen complex-stimulated RBL-2H3 cells and asthma model mice.	chitosan oligosaccharides	50-75	RB transcriptional corepressor like 2	Rattus norvegicus	110-115
19929981-0	2010	Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases.	chitosan oligosaccharides	0-25	interleukin 6	Homo sapiens	52-65
19929981-0	2010	Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases.	chitosan oligosaccharides	0-25	mitogen-activated protein kinase 1	Homo sapiens	143-146
19929981-0	2010	Chitosan oligosaccharides inhibit the expression of interleukin-6 in lipopolysaccharide-induced human umbilical vein endothelial cells through p38 and ERK1/2 protein kinases.	chitosan oligosaccharides	0-25	mitogen-activated protein kinase 3	Homo sapiens	151-157