PMID-sentid Pub_year Sent_text compound_name comp_offset prot_official_name organism prot_offset 29138023-4 2018 In the present study, oleanonic acid inhibited the elevation of transcriptional activity of NF-kappaB and reduced the mRNA expressions of hypertrophic genes such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) in a concentration-dependent manner in phenylephrine (PE)-treated cardiomyocytes. oleanonic acid 22-36 natriuretic peptide A Rattus norvegicus 165-190 35215943-4 2022 Our study identified four hits, including angeloylgomisin O, schisandrin B, procyanidin, and oleanonic acid, as effective SARS-CoV-2 S pv entry inhibitors in the micromolar range. oleanonic acid 93-107 surface glycoprotein Severe acute respiratory syndrome coronavirus 2 133-134 32739573-8 2020 The inhibitory mechanism of oleanonic acid (the most potent CYP3A inhibitor occurring in Styrax) against CYP3A4 was investigated by a panel of inhibition kinetics analyses and in silico analysis. oleanonic acid 28-42 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 60-65 32739573-8 2020 The inhibitory mechanism of oleanonic acid (the most potent CYP3A inhibitor occurring in Styrax) against CYP3A4 was investigated by a panel of inhibition kinetics analyses and in silico analysis. oleanonic acid 28-42 cytochrome P450 family 3 subfamily A member 4 Homo sapiens 105-111 32739573-12 2020 Five pentacyclic triterpenoid acids (including epibetulinic acid, betulinic acid, betulonic acid, oleanonic acid and maslinic acid) present in Styrax were potent CYP3A inhibitors, and oleanonic acid was a competitive inhibitor against CYP3A-mediated testosterone 6beta-hydroxylation. oleanonic acid 98-112 cytochrome P450, family 3, subfamily a, polypeptide 62 Rattus norvegicus 162-167 29138023-4 2018 In the present study, oleanonic acid inhibited the elevation of transcriptional activity of NF-kappaB and reduced the mRNA expressions of hypertrophic genes such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) in a concentration-dependent manner in phenylephrine (PE)-treated cardiomyocytes. oleanonic acid 22-36 natriuretic peptide A Rattus norvegicus 192-195 29138023-4 2018 In the present study, oleanonic acid inhibited the elevation of transcriptional activity of NF-kappaB and reduced the mRNA expressions of hypertrophic genes such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) in a concentration-dependent manner in phenylephrine (PE)-treated cardiomyocytes. oleanonic acid 22-36 natriuretic peptide B Rattus norvegicus 201-226 29138023-4 2018 In the present study, oleanonic acid inhibited the elevation of transcriptional activity of NF-kappaB and reduced the mRNA expressions of hypertrophic genes such as atrial natriuretic factor (ANF) and brain natriuretic peptide (BNP) in a concentration-dependent manner in phenylephrine (PE)-treated cardiomyocytes. oleanonic acid 22-36 natriuretic peptide B Rattus norvegicus 228-231